## Tue Feb 17 09:50:41 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/HKD3_bin.82.fa -m mmseqs --output HKD3_bin.82 --output_dir /data/result/bins/wyx/eggqs50+/HKD3_bin.82 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD3_k127_1012661_3	543728.Vapar_3347	8.175e-121	401.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4A9W1@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD3_k127_1012661_0	543728.Vapar_3348	2.167e-202	638.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2WECP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD3_k127_1012661_1	543728.Vapar_3349	3.493e-141	452.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VSSA@28216|Betaproteobacteria,4AEKS@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_1012661_2	543728.Vapar_3350	9.687e-128	413.0	COG0395@1|root,COG0395@2|Bacteria,1PFNZ@1224|Proteobacteria,2W9E3@28216|Betaproteobacteria,4AHXM@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_1012661_4	1321781.HMPREF1985_01484	3.377e-119	401.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4H3P1@909932|Negativicutes	909932|Negativicutes	G	carbohydrate kinase, FGGY	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD3_k127_1012661_9	1123274.KB899407_gene193	7.98e-49	199.0	COG1349@1|root,COG1349@2|Bacteria,2J852@203691|Spirochaetes	203691|Spirochaetes	K	DeoR C terminal sensor domain	-	-	-	ko:K06608	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
HKD3_k127_1012661_8	717605.Theco_0988	8.342e-84	306.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,4H9W0@91061|Bacilli,26SKE@186822|Paenibacillaceae	91061|Bacilli	G	links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source	araD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
HKD3_k127_1012661_5	1286170.RORB6_19590	1.664e-109	361.0	COG3623@1|root,COG3623@2|Bacteria,1MWTD@1224|Proteobacteria,1RPT6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	3-epimerase	sgbU	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019324,GO:0034015,GO:0044238,GO:0044281,GO:0071704	5.1.3.22	ko:K03079	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R03244	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	AP_endonuc_2
HKD3_k127_1012661_6	1415775.U729_1968	8.665e-107	357.0	28IPH@1|root,2Z8PG@2|Bacteria,1TREB@1239|Firmicutes,248QM@186801|Clostridia,36EYZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1012661_7	450851.PHZ_c3271	1.872e-88	301.0	COG0625@1|root,COG0625@2|Bacteria,1NUET@1224|Proteobacteria,2TRGC@28211|Alphaproteobacteria,2KJCX@204458|Caulobacterales	204458|Caulobacterales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
HKD3_k127_1012661_10	1163617.SCD_n02617	6.937e-32	124.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD3_k127_113754_26	765869.BDW_02690	2.458e-25	109.0	COG1651@1|root,COG1651@2|Bacteria,1NZPQ@1224|Proteobacteria,42U1T@68525|delta/epsilon subdivisions,2MSXR@213481|Bdellovibrionales,2WQH9@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	PFAM DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD3_k127_113754_0	886293.Sinac_2778	0.0	1050.0	COG3119@1|root,COG3119@2|Bacteria,2IX0Y@203682|Planctomycetes	203682|Planctomycetes	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD3_k127_113754_4	1223521.BBJX01000008_gene1396	7.392e-205	655.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2VQGI@28216|Betaproteobacteria,4AJPU@80864|Comamonadaceae	28216|Betaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_113754_20	395961.Cyan7425_0454	4.21e-66	259.0	COG3153@1|root,COG3153@2|Bacteria,1GK4X@1117|Cyanobacteria,3KIFY@43988|Cyanothece	1117|Cyanobacteria	S	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_9
HKD3_k127_113754_22	1441930.Z042_14460	4.416e-46	188.0	COG1309@1|root,COG1309@2|Bacteria,1N11B@1224|Proteobacteria,1S8PU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_113754_12	1223521.BBJX01000001_gene1020	3.373e-136	443.0	COG0778@1|root,COG0778@2|Bacteria,1NTK9@1224|Proteobacteria,2VYQ2@28216|Betaproteobacteria,4AGFC@80864|Comamonadaceae	28216|Betaproteobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_113754_1	887898.HMPREF0551_2316	2.708e-306	949.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,1K30A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD3_k127_113754_2	1095769.CAHF01000005_gene1443	2.024e-220	692.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,472BG@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
HKD3_k127_113754_27	358220.C380_18410	2.434e-20	102.0	2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,2VR1F@28216|Betaproteobacteria,4AE93@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_113754_11	1500301.JQMF01000038_gene5906	5.656e-139	460.0	COG0148@1|root,COG0148@2|Bacteria,1PIEJ@1224|Proteobacteria,2TT8V@28211|Alphaproteobacteria,4BD27@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	-	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD3_k127_113754_15	1122132.AQYH01000004_gene1605	1.266e-110	369.0	COG4857@1|root,COG4857@2|Bacteria,1MXBW@1224|Proteobacteria,2TR0Z@28211|Alphaproteobacteria,4BD98@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD3_k127_113754_6	1100720.ALKN01000030_gene1143	1.531e-192	612.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,4AAXN@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K14392	-	-	-	-	ko00000,ko02000	2.A.21.1	-	-	SSF
HKD3_k127_113754_3	887898.HMPREF0551_2320	2.18e-206	654.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,1K4J7@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD3_k127_113754_21	402626.Rpic_0498	9.852e-56	221.0	COG3240@1|root,COG3240@2|Bacteria,1MYGD@1224|Proteobacteria,2VSIV@28216|Betaproteobacteria,1K0TU@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PFAM lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
HKD3_k127_113754_10	1095769.CAHF01000005_gene1441	5.882e-140	451.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,473FX@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD3_k127_113754_24	420662.Mpe_A0553	8.914e-38	158.0	COG1539@1|root,COG1539@2|Bacteria,1MY5Q@1224|Proteobacteria,2VRBR@28216|Betaproteobacteria,1KM7C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD3_k127_113754_18	1198452.Jab_1c06170	3.175e-85	294.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,473CM@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_113754_13	1454004.AW11_00156	1.371e-119	399.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,1KPXM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD3_k127_113754_23	1000565.METUNv1_03628	3.742e-43	181.0	28TB7@1|root,2ZFJR@2|Bacteria,1PACM@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_113754_28	1157708.KB907452_gene4034	3.481e-16	91.0	2EITT@1|root,33CJ3@2|Bacteria,1NH36@1224|Proteobacteria,2VXT6@28216|Betaproteobacteria,4AFEX@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD3_k127_113754_7	1265502.KB905960_gene300	1.874e-175	565.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,4AAWR@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD3_k127_113754_17	1031711.RSPO_c03271	4.466e-88	297.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2VI65@28216|Betaproteobacteria,1K2SD@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	gst8	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_3,GST_C_4,GST_N_3
HKD3_k127_113754_16	1392838.AWNM01000031_gene41	7.363e-97	328.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,3T2US@506|Alcaligenaceae	28216|Betaproteobacteria	GM	NAD dependent epimerase dehydratase family protein	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
HKD3_k127_113754_8	1217718.ALOU01000066_gene1926	5.132e-162	542.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2VHPK@28216|Betaproteobacteria,1K124@119060|Burkholderiaceae	28216|Betaproteobacteria	M	lytic transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
HKD3_k127_113754_25	887898.HMPREF0551_2329	2.443e-32	134.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2VJZE@28216|Betaproteobacteria,1K4BZ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD3_k127_113754_9	887898.HMPREF0551_2331	3.157e-150	494.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2VHR0@28216|Betaproteobacteria,1K6NR@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Domain of unknown function (DUF3391)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
HKD3_k127_113754_14	1121035.AUCH01000008_gene1036	1.511e-115	392.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,2KUZ9@206389|Rhodocyclales	206389|Rhodocyclales	E	5,10-methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD3_k127_113754_19	1121035.AUCH01000008_gene1035	7.214e-76	267.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2VK8J@28216|Betaproteobacteria,2KV28@206389|Rhodocyclales	206389|Rhodocyclales	J	RNA-binding S4 domain-containing protein	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD3_k127_113754_5	887898.HMPREF0551_2334	1.002e-196	616.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1K11D@119060|Burkholderiaceae	28216|Betaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD3_k127_1257023_0	391038.Bphy_1488	0.0	1451.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,1K087@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Atp-dependent helicase	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HKD3_k127_1257023_8	1496688.ER33_02335	9.081e-51	197.0	COG3812@1|root,COG3812@2|Bacteria,1G5A3@1117|Cyanobacteria,22ST5@167375|Cyanobium	1117|Cyanobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
HKD3_k127_1257023_10	469371.Tbis_1633	1.431e-46	183.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria,4E06X@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.14.14.12	ko:K16047	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09819	RC00236	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HKD3_k127_1257023_9	267608.RSp1346	2.961e-48	192.0	COG0251@1|root,COG0251@2|Bacteria,1N2GQ@1224|Proteobacteria,2W25K@28216|Betaproteobacteria,1K8VA@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_1257023_12	314265.R2601_13589	7.305e-41	164.0	COG0679@1|root,COG0679@2|Bacteria,1PINE@1224|Proteobacteria,2TUJR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD3_k127_1257023_3	795666.MW7_3482	4.433e-126	411.0	COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VKXA@28216|Betaproteobacteria,1K2ZY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HKD3_k127_1257023_6	1175306.GWL_10730	7.007e-92	310.0	COG0726@1|root,COG0726@2|Bacteria,1MX3V@1224|Proteobacteria,2VJVH@28216|Betaproteobacteria,4738F@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	xylanase chitin deacetylase	pdaA	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD3_k127_1257023_4	864051.BurJ1DRAFT_1436	8.166e-110	376.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2VJE7@28216|Betaproteobacteria,1KJHK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD3_k127_1257023_11	123899.JPQP01000022_gene3377	1.107e-45	174.0	COG2981@1|root,COG2981@2|Bacteria,1R9QA@1224|Proteobacteria,2WE8B@28216|Betaproteobacteria,3T99D@506|Alcaligenaceae	28216|Betaproteobacteria	E	Etoposide-induced protein 2.4 (EI24)	-	-	-	-	-	-	-	-	-	-	-	-	EI24
HKD3_k127_1257023_7	29581.BW37_03648	3.287e-70	245.0	COG0639@1|root,COG0639@2|Bacteria,1N4BG@1224|Proteobacteria,2VIYC@28216|Betaproteobacteria,4776H@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD3_k127_1257023_5	1003200.AXXA_15907	2.175e-104	351.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,3T204@506|Alcaligenaceae	28216|Betaproteobacteria	S	nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	yfaY	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD3_k127_1257023_1	748247.AZKH_4019	0.0	1330.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,2KUJ8@206389|Rhodocyclales	206389|Rhodocyclales	C	COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HKD3_k127_1257023_2	159450.NH14_18900	2.266e-193	612.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
HKD3_k127_1260253_5	335543.Sfum_0593	7.098e-138	446.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,2MS10@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_1260253_3	460265.Mnod_2274	3.988e-214	679.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,1JR06@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD3_k127_1260253_12	388051.AUFE01000020_gene4183	5.519e-107	354.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VIWA@28216|Betaproteobacteria,1JZW2@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K03442,ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.4	-	-	MS_channel,TM_helix
HKD3_k127_1260253_26	266264.Rmet_1200	2.183e-37	147.0	COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,1JZMD@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM phasin family protein	phaP	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD3_k127_1260253_14	883126.HMPREF9710_01809	1.446e-96	328.0	COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2VMQB@28216|Betaproteobacteria,4725D@75682|Oxalobacteraceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_1260253_13	864051.BurJ1DRAFT_3000	3.324e-101	351.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KJDZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD3_k127_1260253_8	887898.HMPREF0551_1249	2.163e-126	409.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,1JZS2@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	yiaJ	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD3_k127_1260253_11	93220.LV28_24465	2.516e-112	368.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VNV2@28216|Betaproteobacteria,1K0C9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
HKD3_k127_1260253_2	1095769.CAHF01000011_gene2738	1.058e-225	706.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,476B8@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	LUD domain	lutB	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
HKD3_k127_1260253_7	926560.KE387023_gene3824	1.61e-134	458.0	COG0665@1|root,COG0665@2|Bacteria,1WIHS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD3_k127_1260253_20	869210.Marky_1461	4.451e-77	292.0	COG2423@1|root,COG2423@2|Bacteria,1WINC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ornithine cyclodeaminase mu-crystallin	-	-	1.5.1.1,4.3.1.12	ko:K01750,ko:K19743	ko00310,ko00330,ko00960,ko01100,ko01110,ko01130,ko01230,map00310,map00330,map00960,map01100,map01110,map01130,map01230	-	R00671,R01246,R01249,R02201,R02203	RC00135,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HKD3_k127_1260253_4	1095769.CAHF01000014_gene3154	1.881e-186	599.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,2VPEG@28216|Betaproteobacteria,472QT@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Protein of unknown function (DUF4080)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
HKD3_k127_1260253_15	1297863.APJF01000038_gene1769	5.786e-96	319.0	2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2TSBD@28211|Alphaproteobacteria,3JT2X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Nitrile hydratase, alpha chain	nthA	-	4.2.1.84	ko:K01721	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R02828,R04020,R05379,R05596,R07780,R07854	RC00483,RC00792,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_alpha
HKD3_k127_1260253_16	1218084.BBJK01000061_gene4691	1.068e-85	317.0	28I45@1|root,2Z87Q@2|Bacteria,1R432@1224|Proteobacteria,2VTKQ@28216|Betaproteobacteria,1K5RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	NHase catalyzes the hydration of various nitrile compounds to the corresponding amides	-	-	4.2.1.84	ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R04020,R05379,R05596,R07780,R07854	RC00483,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_beta
HKD3_k127_1260253_28	1380391.JIAS01000001_gene2654	6.466e-35	147.0	2E3CR@1|root,32YC0@2|Bacteria,1N9Q9@1224|Proteobacteria,2UF5B@28211|Alphaproteobacteria,2JU38@204441|Rhodospirillales	204441|Rhodospirillales	S	Nitrile hydratase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	NHase_beta
HKD3_k127_1260253_24	85643.Tmz1t_3199	1.294e-42	175.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,2KWMU@206389|Rhodocyclales	206389|Rhodocyclales	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
HKD3_k127_1260253_6	93220.LV28_24485	1.325e-137	447.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,1K0GT@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_1260253_9	204773.HEAR2443	4.428e-120	389.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,473K0@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD3_k127_1260253_21	440512.C211_22772	8.263e-76	261.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD3_k127_1260253_22	365046.Rta_19360	2.346e-72	259.0	COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,2VVI5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	plastoquinol--plastocyanin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1260253_19	1097668.BYI23_A015860	6.871e-78	267.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,1K0AH@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the Nudix hydrolase family	nudC_1	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
HKD3_k127_1260253_31	247633.GP2143_11944	2.345e-07	62.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1260253_18	1217718.ALOU01000019_gene2737	1.82e-78	270.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2VKIN@28216|Betaproteobacteria,1K1RS@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD3_k127_1260253_10	887898.HMPREF0551_1238	7.608e-116	394.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,1K0N5@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD3_k127_1260253_25	882378.RBRH_03643	3.019e-39	155.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2VRKC@28216|Betaproteobacteria,1JZUM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD3_k127_1260253_1	887898.HMPREF0551_1235	4.105e-244	776.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,1K0A5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD3_k127_1260253_0	887898.HMPREF0551_1234	0.0	1140.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1K43X@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
HKD3_k127_1260253_29	1123354.AUDR01000016_gene1389	5.474e-20	92.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,1KRTU@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosome-binding factor A	-	-	-	-	-	-	-	-	-	-	-	-	RBFA
HKD3_k127_1260253_17	85643.Tmz1t_1694	3.638e-81	287.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,2KVRT@206389|Rhodocyclales	206389|Rhodocyclales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD3_k127_1260253_27	1000565.METUNv1_00841	2.46e-36	140.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,2KX1E@206389|Rhodocyclales	206389|Rhodocyclales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD3_k127_1260253_23	1163617.SCD_n01711	3.258e-59	207.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD3_k127_1277962_6	887898.HMPREF0551_0786	3.105e-53	189.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1K532@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD3_k127_1277962_0	595537.Varpa_2455	2.553e-320	992.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	korC	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3
HKD3_k127_1277962_1	595537.Varpa_2456	1.392e-303	944.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,4A9VY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD3_k127_1277962_4	522306.CAP2UW1_2584	1.607e-187	590.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_1277962_3	757424.Hsero_2970	1.476e-237	739.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,472V7@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD3_k127_1277962_7	795666.MW7_1307	4.478e-20	106.0	COG2938@1|root,COG2938@2|Bacteria,1N2AS@1224|Proteobacteria,2VVYR@28216|Betaproteobacteria,1K9J5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HKD3_k127_1277962_5	1003200.AXXA_17771	7.956e-145	462.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,3T2B6@506|Alcaligenaceae	28216|Betaproteobacteria	C	SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556	sdhB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
HKD3_k127_1277962_2	887898.HMPREF0551_0795	2.626e-302	931.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1K242@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD3_k127_1280009_3	1454004.AW11_02095	9.165e-61	215.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,2WG7R@28216|Betaproteobacteria,1KQVR@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD3_k127_1280009_4	237368.SCABRO_03837	2.286e-27	127.0	29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1280009_0	296591.Bpro_4252	2.322e-280	873.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,4A9P5@80864|Comamonadaceae	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD3_k127_1280009_2	296591.Bpro_4253	2.206e-71	268.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,4ADS4@80864|Comamonadaceae	28216|Betaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_1280009_1	296591.Bpro_4254	1.424e-93	327.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2VH62@28216|Betaproteobacteria,4AA9K@80864|Comamonadaceae	28216|Betaproteobacteria	T	osmosensitive K channel	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD3_k127_1336526_7	420662.Mpe_A1374	5.553e-11	64.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,1KJBK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HKD3_k127_1336526_0	887898.HMPREF0551_1301	2.742e-193	613.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,1K2AE@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
HKD3_k127_1336526_5	557598.LHK_00821	1.525e-27	117.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD3_k127_1336526_1	395495.Lcho_4213	4.004e-113	374.0	COG3221@1|root,COG3221@2|Bacteria,1PFRG@1224|Proteobacteria,2WAUH@28216|Betaproteobacteria,1KP72@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD3_k127_1336526_4	887062.HGR_09329	1.335e-38	167.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,4AJZ3@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg
HKD3_k127_1336526_2	557598.LHK_00822	8.018e-110	389.0	COG2172@1|root,COG2202@1|root,COG2208@1|root,COG3437@1|root,COG2172@2|Bacteria,COG2202@2|Bacteria,COG2208@2|Bacteria,COG3437@2|Bacteria,1NWNJ@1224|Proteobacteria,2WHQD@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,Response_reg
HKD3_k127_1336526_3	1129794.C427_4367	1.113e-84	284.0	COG1060@1|root,COG1060@2|Bacteria,1N4ZG@1224|Proteobacteria,1SR1B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Haem-NO-binding	-	-	-	-	-	-	-	-	-	-	-	-	HNOB
HKD3_k127_1336526_6	1121890.AUDO01000019_gene1053	1.476e-22	113.0	COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,4NF1K@976|Bacteroidetes,1IINU@117743|Flavobacteriia,2P0EW@237|Flavobacterium	976|Bacteroidetes	T	Heme NO binding associated	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HNOBA,HisKA,PAS_9
HKD3_k127_1369813_2	339670.Bamb_2109	2.999e-123	404.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,1K1SF@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the aspartokinase family	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD3_k127_1369813_4	190650.CC_3308	3.035e-89	304.0	COG2267@1|root,COG2267@2|Bacteria,1R9GQ@1224|Proteobacteria,2U3YF@28211|Alphaproteobacteria,2KGD4@204458|Caulobacterales	204458|Caulobacterales	I	PFAM alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD3_k127_1369813_5	667632.KB890169_gene4961	1.855e-76	273.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2VP12@28216|Betaproteobacteria,1K2I6@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD3_k127_1369813_1	883126.HMPREF9710_04292	5.507e-164	525.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,472PA@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD3_k127_1369813_6	388051.AUFE01000014_gene6103	6.074e-75	257.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,1K0UG@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM HhH-GPD family protein	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD3_k127_1369813_3	375286.mma_0185	8.156e-99	351.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2VKQ6@28216|Betaproteobacteria,476M3@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1369813_0	859657.RPSI07_2210	5.188e-217	680.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,1K49A@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD3_k127_1391733_0	375286.mma_0581	2.879e-235	743.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,4739Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_1391733_7	535289.Dtpsy_1029	1.011e-100	334.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria,4ABG2@80864|Comamonadaceae	28216|Betaproteobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like)	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HKD3_k127_1391733_6	365046.Rta_20290	7.339e-102	343.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VM3I@28216|Betaproteobacteria,4AB0D@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_1391733_1	1217718.ALOU01000013_gene340	3.377e-235	736.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1K17A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD3_k127_1391733_10	1156919.QWC_20290	4.909e-34	143.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2VT41@28216|Betaproteobacteria,3T42Y@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD3_k127_1391733_4	381666.H16_A2772	2.011e-129	424.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VK73@28216|Betaproteobacteria,1KDB0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_1391733_5	543728.Vapar_0833	1.709e-103	346.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VIJ6@28216|Betaproteobacteria,4AA2C@80864|Comamonadaceae	28216|Betaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_1391733_2	977880.RALTA_A1248	2.851e-192	621.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_1391733_9	264198.Reut_A1264	8.439e-45	175.0	COG3090@1|root,COG3090@2|Bacteria,1RDY3@1224|Proteobacteria,2VRWQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter dctq component	yiaM_2	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_1391733_3	365046.Rta_29510	9.354e-149	482.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACTU@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD3_k127_1391733_8	365046.Rta_29520	2.133e-79	269.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,4ADS6@80864|Comamonadaceae	28216|Betaproteobacteria	C	dehydrogenase, E1 component	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD3_k127_1395365_4	626418.bglu_1g04500	7.155e-108	357.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K0P4@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_1395365_3	1286093.C266_24650	4.094e-109	360.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2VHE9@28216|Betaproteobacteria,1K144@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_1395365_5	859657.RPSI07_0630	4.745e-41	161.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2VRC2@28216|Betaproteobacteria,1KHAU@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	phenylacetic acid degradation protein	paaI	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD3_k127_1395365_0	1071679.BG57_26710	3.892e-217	690.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,1K11N@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD3_k127_1395365_2	883126.HMPREF9710_04819	6.856e-136	463.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	alcohol dehydrogenase	-	-	-	ko:K19745	ko00640,ko01100,map00640,map01100	-	R00919	RC00095	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_1395365_1	1000565.METUNv1_00501	3.443e-175	557.0	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2VH5R@28216|Betaproteobacteria,2KUU7@206389|Rhodocyclales	206389|Rhodocyclales	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HKD3_k127_1472435_13	1205680.CAKO01000038_gene1931	3.387e-37	143.0	COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2U5B0@28211|Alphaproteobacteria,2JRTH@204441|Rhodospirillales	204441|Rhodospirillales	C	NADH dehydrogenase NAD(P)H nitroreductase	rutE	-	-	ko:K09019	ko00240,ko01100,map00240,map01100	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HKD3_k127_1472435_7	1380391.JIAS01000011_gene5283	9.338e-114	373.0	COG3485@1|root,COG3485@2|Bacteria,1MX7W@1224|Proteobacteria,2TT8T@28211|Alphaproteobacteria,2JS24@204441|Rhodospirillales	204441|Rhodospirillales	Q	Catechol dioxygenase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C,Dioxygenase_N
HKD3_k127_1472435_1	1265502.KB905934_gene3249	5.883e-189	600.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,4A9IZ@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	pcaF	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_1472435_8	864073.HFRIS_002549	3.895e-109	357.0	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VIBE@28216|Betaproteobacteria,473D5@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Coenzyme A transferase	pcaJ	-	2.8.3.6	ko:K01032	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_1472435_9	93220.LV28_17790	4.787e-108	356.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VIR2@28216|Betaproteobacteria,1K1JX@119060|Burkholderiaceae	28216|Betaproteobacteria	I	TIGRFAM 3-oxoacid CoA-transferase, A subunit	pcaI	-	2.8.3.6	ko:K01031	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_1472435_2	272134.KB731324_gene1778	5.875e-188	606.0	COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria,1H9SQ@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18,2.6.1.62	ko:K00822,ko:K00833	ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100	M00123,M00573,M00577	R00907,R03231,R04187	RC00006,RC00008,RC00062,RC00160,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_1472435_4	887898.HMPREF0551_2295	7.85e-181	578.0	COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2WGIZ@28216|Betaproteobacteria,1KIKX@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Major Facilitator	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
HKD3_k127_1472435_11	977880.RALTA_A0162	1.618e-93	317.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,1JZNN@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD3_k127_1472435_0	1121937.AUHJ01000008_gene2009	1.319e-242	774.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,464U8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD3_k127_1472435_3	1304883.KI912532_gene771	2.646e-186	595.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2VHBA@28216|Betaproteobacteria,2KUPM@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function DUF21	tlyC	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD3_k127_1472435_5	1380355.JNIJ01000070_gene5806	7.554e-176	564.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2U0H3@28211|Alphaproteobacteria,3JR1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	2.7.10.2,3.3.2.9	ko:K01253,ko:K08253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD3_k127_1472435_10	358220.C380_17595	4.141e-95	333.0	COG0702@1|root,COG0702@2|Bacteria,1NYJ7@1224|Proteobacteria	1224|Proteobacteria	GM	NmrA-like family	-	-	-	ko:K07118	-	-	-	-	ko00000	-	-	-	NAD_binding_10
HKD3_k127_1472435_6	748247.AZKH_4350	8.062e-122	396.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,2KV3I@206389|Rhodocyclales	206389|Rhodocyclales	L	Endonuclease/Exonuclease/phosphatase family	xthA2	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD3_k127_1472435_12	887898.HMPREF0551_2290	5.859e-80	273.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,1K5RF@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD3_k127_150077_4	1157708.KB907463_gene711	7.647e-34	139.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VMJZ@28216|Betaproteobacteria,4AAV4@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_150077_6	1521187.JPIM01000082_gene192	4.608e-18	87.0	COG4281@1|root,COG4281@2|Bacteria,2G98T@200795|Chloroflexi,377KT@32061|Chloroflexia	32061|Chloroflexia	I	PFAM acyl-coA-binding protein, ACBP	-	-	-	-	-	-	-	-	-	-	-	-	ACBP
HKD3_k127_150077_2	765910.MARPU_06830	6.16e-65	236.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WWAK@135613|Chromatiales	135613|Chromatiales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD3_k127_150077_5	583355.Caka_0264	3.807e-23	105.0	COG2905@1|root,COG2905@2|Bacteria,46T3B@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_150077_0	1121441.AUCX01000006_gene992	5.657e-182	578.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,42MXC@68525|delta/epsilon subdivisions,2WJJF@28221|Deltaproteobacteria,2MABI@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidoreductase FAD-binding domain	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_150077_1	1121918.ARWE01000001_gene1330	3.315e-79	269.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria	1224|Proteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
HKD3_k127_150077_3	225937.HP15_2250	7.102e-62	215.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,46413@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
HKD3_k127_156226_17	754035.Mesau_04941	1.62e-61	216.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TSWB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	2-keto-4-pentenoate hydratase	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_156226_4	1532557.JL37_25265	2.891e-192	605.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VM1E@28216|Betaproteobacteria,3T2D5@506|Alcaligenaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_156226_6	1123504.JQKD01000002_gene3730	2.212e-141	462.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,4ACU4@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD3_k127_156226_10	266264.Rmet_4457	6.549e-105	359.0	COG3181@1|root,COG3181@2|Bacteria,1MYJX@1224|Proteobacteria,2VM8F@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_156226_22	266264.Rmet_4456	1.368e-43	166.0	COG0662@1|root,COG0662@2|Bacteria,1RH1E@1224|Proteobacteria,2VSQU@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_156226_9	864051.BurJ1DRAFT_4435	6.196e-108	361.0	COG0697@1|root,COG0697@2|Bacteria,1PB22@1224|Proteobacteria,2VYG5@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_156226_20	426114.THI_3806	1.279e-50	186.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,1KM2J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Thioredoxin	trxC	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
HKD3_k127_156226_3	391735.Veis_1862	1.892e-231	725.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VJ3D@28216|Betaproteobacteria,4ABAW@80864|Comamonadaceae	28216|Betaproteobacteria	Q	D-aminoacylase domain protein	dan	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD3_k127_156226_2	338969.Rfer_2479	1.72e-274	854.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,4AG8M@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD3_k127_156226_14	312153.Pnuc_1376	2.132e-73	250.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,2VQ31@28216|Betaproteobacteria,1K75H@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD3_k127_156226_23	312153.Pnuc_1377	1.937e-23	109.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,1KACH@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Rubredoxin	rubA1	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD3_k127_156226_11	76114.ebA6036	5.158e-94	325.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2WGST@28216|Betaproteobacteria,2KYB6@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_156226_25	748247.AZKH_1497	1.437e-15	80.0	2E1DK@1|root,32WSU@2|Bacteria,1N3VJ@1224|Proteobacteria,2VV0D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_156226_13	305700.B447_14149	1.754e-77	264.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,2KW4E@206389|Rhodocyclales	206389|Rhodocyclales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD3_k127_156226_12	614083.AWQR01000018_gene1805	5.399e-82	290.0	COG0477@1|root,COG2814@2|Bacteria,1MU9G@1224|Proteobacteria,2VITW@28216|Betaproteobacteria,4AD7H@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K19577	-	-	-	-	ko00000,ko02000	2.A.1.2.65	-	-	MFS_1
HKD3_k127_156226_16	522306.CAP2UW1_1484	6.469e-68	259.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VI5H@28216|Betaproteobacteria,1KQSH@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	EG	EamA-like transporter family	yijE_1	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_156226_5	522306.CAP2UW1_1486	9.644e-166	561.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,2VIWW@28216|Betaproteobacteria	28216|Betaproteobacteria	K	helix-turn-helix- domain containing protein, AraC type	ada	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HKD3_k127_156226_1	1207063.P24_05877	2.401e-279	868.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2JQ5K@204441|Rhodospirillales	204441|Rhodospirillales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD3_k127_156226_19	1089455.MOPEL_001_00460	7.439e-51	185.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4F75N@85018|Dermatophilaceae	201174|Actinobacteria	J	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
HKD3_k127_156226_21	395495.Lcho_4106	1.514e-46	174.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,1KKWU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD3_k127_156226_15	1095769.CAHF01000014_gene3080	1.601e-70	271.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,2VKBX@28216|Betaproteobacteria,473U2@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD3_k127_156226_18	1095769.CAHF01000014_gene3081	4.509e-55	202.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2WFQ4@28216|Betaproteobacteria,473PZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD3_k127_156226_0	748247.AZKH_p0651	0.0	1702.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2VI52@28216|Betaproteobacteria,2KXS7@206389|Rhodocyclales	206389|Rhodocyclales	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	-	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
HKD3_k127_156226_8	887898.HMPREF0551_1461	5.728e-116	395.0	COG1404@1|root,COG1404@2|Bacteria,1QU1I@1224|Proteobacteria,2VTI0@28216|Betaproteobacteria,1K9Z9@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Convertase P-domain protein	-	-	3.4.21.121	ko:K20755	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	P_proprotein,Peptidase_S8
HKD3_k127_156226_24	29581.BW37_00699	1.643e-19	97.0	2C0PG@1|root,330E3@2|Bacteria,1RA6M@1224|Proteobacteria,2VW6R@28216|Betaproteobacteria,474E0@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD3_k127_156226_7	267608.RSc2125	4.108e-127	417.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2VJ68@28216|Betaproteobacteria,1K2UW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD3_k127_1572759_0	264198.Reut_A0476	4.463e-190	630.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,1JZQB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,S4_2,tRNA-synt_1b
HKD3_k127_1572759_3	1095769.CAHF01000001_gene3535	6.032e-107	361.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,472BW@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD3_k127_1572759_2	360910.BAV2965	4.451e-108	363.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,3T1E6@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
HKD3_k127_1572759_5	882378.RBRH_02069	2.79e-62	217.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1K791@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
HKD3_k127_1572759_7	1095769.CAHF01000001_gene3538	1.241e-40	154.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,474AK@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	ccmA	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_1572759_6	204773.HEAR0243	2.839e-42	166.0	28IJP@1|root,2Z8KI@2|Bacteria,1R9DP@1224|Proteobacteria,2VTVJ@28216|Betaproteobacteria,478NV@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1572759_1	1095769.CAHF01000001_gene3540	5.203e-176	567.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,472KD@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD3_k127_1572759_4	1231391.AMZF01000110_gene901	1.029e-63	221.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria,3T3HS@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD3_k127_1582122_4	987059.RBXJA2T_07573	5.17e-92	305.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,1KNFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD3_k127_1582122_2	296591.Bpro_3122	2.445e-103	357.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_1582122_6	1041139.KB902579_gene4594	8.698e-54	201.0	2C2X7@1|root,2ZFQR@2|Bacteria,1R940@1224|Proteobacteria,2U3U6@28211|Alphaproteobacteria,4BP4T@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD3_k127_1582122_3	94624.Bpet0244	1.389e-97	329.0	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2VRAJ@28216|Betaproteobacteria,3T20R@506|Alcaligenaceae	28216|Betaproteobacteria	K	Transcriptional regulator	paiB	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
HKD3_k127_1582122_0	748280.NH8B_2704	1.008e-304	950.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,2KSMJ@206351|Neisseriales	206351|Neisseriales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD3_k127_1582122_5	748247.AZKH_3901	2.337e-54	211.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,2KWI4@206389|Rhodocyclales	206389|Rhodocyclales	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD3_k127_1582122_1	983917.RGE_37240	4.395e-159	505.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2VJ36@28216|Betaproteobacteria,1KKKJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661,ko:K07536	ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220	M00116,M00540	R05592,R07263	RC01429,RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_1582122_7	983917.RGE_37230	3.942e-47	179.0	COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,2VPB2@28216|Betaproteobacteria,1KN5F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_1644640_23	391615.ABSJ01000034_gene1064	3.544e-132	448.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1J4QC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	COG0643 Chemotaxis protein histidine kinase and related kinases	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD3_k127_1644640_35	522306.CAP2UW1_4181	6.525e-62	218.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VQEB@28216|Betaproteobacteria,1KQW9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_1644640_26	887898.HMPREF0551_0876	8.723e-108	353.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2VIND@28216|Betaproteobacteria,1K1QS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD3_k127_1644640_32	266264.Rmet_2117	2.184e-73	254.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,1JZYZ@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD3_k127_1644640_38	1121127.JAFA01000011_gene3901	2.176e-43	171.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,1K0F3@119060|Burkholderiaceae	28216|Betaproteobacteria	DM	peptidase	nlpD	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
HKD3_k127_1644640_15	1392838.AWNM01000076_gene2479	5.084e-155	534.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2VHJ8@28216|Betaproteobacteria,3T29H@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD3_k127_1644640_13	1038859.AXAU01000001_gene3757	9.792e-173	559.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JUFM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_27905	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_1644640_27	375286.mma_2132	1.722e-102	338.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2VKZV@28216|Betaproteobacteria,472ZM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Belongs to the BI1 family	yccA	-	-	ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HKD3_k127_1644640_34	1223521.BBJX01000012_gene565	1.774e-63	248.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2VQ2J@28216|Betaproteobacteria,4ADHY@80864|Comamonadaceae	28216|Betaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD3_k127_1644640_14	882378.RBRH_03735	9.421e-172	553.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,1K2ZQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD3_k127_1644640_31	887898.HMPREF0551_0869	7.066e-76	272.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,1K0IW@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	Type IV pilus biogenesis	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
HKD3_k127_1644640_39	1123367.C666_14880	4.384e-39	157.0	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,2VVFV@28216|Betaproteobacteria,2KWMY@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD3_k127_1644640_5	1231391.AMZF01000053_gene1161	2.535e-217	680.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,3T1KN@506|Alcaligenaceae	28216|Betaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD3_k127_1644640_11	1169143.KB911034_gene1165	1.942e-190	614.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,1K1PM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD3_k127_1644640_33	1366050.N234_13665	8.923e-71	246.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,1K064@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HKD3_k127_1644640_28	1095769.CAHF01000011_gene2395	1.838e-85	306.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,4732M@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD3_k127_1644640_17	1123504.JQKD01000031_gene4563	7.376e-149	508.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,4ACK5@80864|Comamonadaceae	28216|Betaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD3_k127_1644640_40	795666.MW7_3465	1.369e-37	142.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,1K8J4@119060|Burkholderiaceae	28216|Betaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD3_k127_1644640_24	887898.HMPREF0551_0861	7.382e-131	432.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,1K14J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD3_k127_1644640_22	1144319.PMI16_01146	3.313e-134	443.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,472HK@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
HKD3_k127_1644640_25	1005048.CFU_1923	4.093e-112	372.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,473D3@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD3_k127_1644640_41	522306.CAP2UW1_2913	1.148e-10	67.0	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2VXNJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
HKD3_k127_1644640_20	859657.RPSI07_2152	1.931e-141	462.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,1K0TV@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD3_k127_1644640_10	1120999.JONM01000001_gene1327	6.33e-194	633.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,2KPT5@206351|Neisseriales	206351|Neisseriales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD3_k127_1644640_37	1175306.GWL_22830	4.368e-54	216.0	COG2236@1|root,COG2236@2|Bacteria,1R675@1224|Proteobacteria,2VPZG@28216|Betaproteobacteria,4745R@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Phosphoribosyl transferase domain	gpt	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD3_k127_1644640_2	887898.HMPREF0551_0598	1.362e-290	914.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1K3JV@119060|Burkholderiaceae	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD3_k127_1644640_30	640081.Dsui_1899	6.552e-77	265.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,2KV2Q@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD3_k127_1644640_29	1246995.AFR_22815	1.585e-82	282.0	COG0846@1|root,COG0846@2|Bacteria,2IFPA@201174|Actinobacteria,4DM6A@85008|Micromonosporales	201174|Actinobacteria	K	Sir2 family	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD3_k127_1644640_12	261292.Nit79A3_2959	3.205e-182	604.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,372QB@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD3_k127_1644640_18	266117.Rxyl_0056	6.524e-145	467.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4CPC1@84995|Rubrobacteria	84995|Rubrobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HKD3_k127_1644640_36	1485544.JQKP01000007_gene1968	9.255e-55	218.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,44VRA@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
HKD3_k127_1644640_1	1163617.SCD_n01926	5.62e-321	998.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD3_k127_1644640_6	159087.Daro_0585	7.117e-209	657.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,2KUTG@206389|Rhodocyclales	206389|Rhodocyclales	F	Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_1644640_9	1288494.EBAPG3_21090	3.727e-202	644.0	COG1449@1|root,COG1449@2|Bacteria,1P2YJ@1224|Proteobacteria,2VHA4@28216|Betaproteobacteria,372KA@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD3_k127_1644640_4	1304883.KI912532_gene1387	1.078e-246	780.0	COG1449@1|root,COG1449@2|Bacteria,1Q9WP@1224|Proteobacteria,2VN9S@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
HKD3_k127_1644640_0	1288494.EBAPG3_21170	0.0	1139.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales	28216|Betaproteobacteria	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD3_k127_1644640_19	76114.ebA6917	1.28e-143	503.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2VH1G@28216|Betaproteobacteria,2KU77@206389|Rhodocyclales	206389|Rhodocyclales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD3_k127_1644640_7	757424.Hsero_2798	1.538e-204	672.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,475B2@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	acd12	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_1644640_3	556269.ACDQ01000006_gene1658	1.152e-258	810.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,478MR@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD3_k127_1644640_8	290397.Adeh_1005	5.855e-203	674.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2YUKQ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD3_k127_1644640_16	535289.Dtpsy_2446	2.246e-154	494.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VH2R@28216|Betaproteobacteria,4AATR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD3_k127_1644640_21	420662.Mpe_A0805	1.949e-134	436.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2VHBU@28216|Betaproteobacteria,1KJZ8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD3_k127_1656383_13	1458357.BG58_26640	2.113e-123	400.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria,1K3K6@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_1656383_18	944435.AXAJ01000001_gene216	2.931e-104	358.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VI2N@28216|Betaproteobacteria,1K414@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_1656383_19	266265.Bxe_B0660	3.774e-102	353.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VI3W@28216|Betaproteobacteria,1K1QP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_1656383_3	1169143.KB911035_gene2188	1.841e-212	664.0	COG0402@1|root,COG0402@2|Bacteria,1MVMR@1224|Proteobacteria,2VMY2@28216|Betaproteobacteria,1K4KS@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.18	ko:K15358	ko00760,ko01120,map00760,map01120	-	R07984	RC01933	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD3_k127_1656383_29	391595.RLO149_c040910	9.052e-50	199.0	COG1309@1|root,COG1309@2|Bacteria,1R5AI@1224|Proteobacteria,2U7HG@28211|Alphaproteobacteria,2P57J@2433|Roseobacter	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	MA20_16910	-	-	-	-	-	-	-	-	-	-	-	TetR_C_3,TetR_C_9,TetR_N
HKD3_k127_1656383_11	1205680.CAKO01000002_gene2255	1.303e-130	424.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,2JQFB@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Nitronate monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD3_k127_1656383_5	1144319.PMI16_01606	2.605e-200	647.0	COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,2VGZ5@28216|Betaproteobacteria,4732W@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD3_k127_1656383_22	216591.BCAL2897	5.304e-83	282.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,1K1I9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HKD3_k127_1656383_7	1304883.KI912532_gene2256	1.691e-162	533.0	COG1055@1|root,COG1055@2|Bacteria,1PUZK@1224|Proteobacteria,2VKEF@28216|Betaproteobacteria,2KYH0@206389|Rhodocyclales	206389|Rhodocyclales	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1656383_15	1276756.AUEX01000020_gene3392	6.647e-114	383.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2VMN7@28216|Betaproteobacteria,4AC7E@80864|Comamonadaceae	28216|Betaproteobacteria	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	-	1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R00717,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_1656383_40	1207076.ALAT01000011_gene1471	1.128e-17	86.0	2EGJT@1|root,33ABY@2|Bacteria,1NGI4@1224|Proteobacteria,1SH79@1236|Gammaproteobacteria,1Z35E@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_gran_rgn
HKD3_k127_1656383_36	1265502.KB905939_gene2399	2.684e-34	136.0	COG4281@1|root,COG4281@2|Bacteria,1MZPP@1224|Proteobacteria,2VUK0@28216|Betaproteobacteria,4AEX2@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM acyl-coA-binding protein, ACBP	acb	-	-	-	-	-	-	-	-	-	-	-	ACBP
HKD3_k127_1656383_9	983917.RGE_08500	1.908e-151	499.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VIJ1@28216|Betaproteobacteria,1KKIM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_1656383_24	1173024.KI912149_gene5532	3.859e-61	217.0	COG3803@1|root,COG3803@2|Bacteria,1G55K@1117|Cyanobacteria,1JMWE@1189|Stigonemataceae	1117|Cyanobacteria	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
HKD3_k127_1656383_31	1168059.KB899087_gene1281	8.375e-44	170.0	COG0730@1|root,COG0730@2|Bacteria,1MUJB@1224|Proteobacteria,2TRWP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD3_k127_1656383_33	381666.H16_A2516	9.591e-37	144.0	COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,2WFVC@28216|Betaproteobacteria,1KI6J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
HKD3_k127_1656383_17	477228.YO5_17575	4.943e-105	379.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,1RNT0@1236|Gammaproteobacteria,1Z28R@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0099046,GO:0140097,GO:1901360,GO:1902494	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
HKD3_k127_1656383_8	983917.RGE_37530	2.679e-153	540.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VI92@28216|Betaproteobacteria,1KKD0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD3_k127_1656383_23	469595.CSAG_02658	1.286e-79	289.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria,3WWED@544|Citrobacter	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,AAA_30,UvrD_C_2
HKD3_k127_1656383_38	1385517.N800_00140	2.391e-28	122.0	COG1320@1|root,COG1320@2|Bacteria,1MZ6Z@1224|Proteobacteria,1S8TM@1236|Gammaproteobacteria,1X87C@135614|Xanthomonadales	135614|Xanthomonadales	P	COG1320 Multisubunit Na H antiporter, MnhG subunit	-	-	-	ko:K05564	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	PhaG_MnhG_YufB
HKD3_k127_1656383_39	1131553.JIBI01000002_gene1771	6.141e-25	113.0	COG2212@1|root,COG2212@2|Bacteria,1N8WJ@1224|Proteobacteria,2VWC1@28216|Betaproteobacteria,373JT@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	mnhF	-	-	ko:K05563	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	MrpF_PhaF
HKD3_k127_1656383_30	1384054.N790_13045	8.797e-45	185.0	COG1863@1|root,COG1863@2|Bacteria,1RH9F@1224|Proteobacteria,1S66D@1236|Gammaproteobacteria,1XC0M@135614|Xanthomonadales	135614|Xanthomonadales	P	Na+/H+ ion antiporter subunit	-	-	-	-	-	-	-	-	-	-	-	-	MNHE
HKD3_k127_1656383_10	95619.PM1_0208220	3.006e-141	472.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit	phaD	-	1.6.5.3	ko:K00342,ko:K05561,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
HKD3_k127_1656383_37	1384054.N790_13055	4.937e-34	150.0	COG1006@1|root,COG1006@2|Bacteria,1RH8H@1224|Proteobacteria,1SA5H@1236|Gammaproteobacteria,1X76Q@135614|Xanthomonadales	135614|Xanthomonadales	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05560	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	Oxidored_q2
HKD3_k127_1656383_0	1395571.TMS3_0114425	1.09e-309	994.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit	phaA	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
HKD3_k127_1656383_12	420662.Mpe_A1716	1.816e-130	431.0	COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria,2VMK4@28216|Betaproteobacteria,1KKKP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HKD3_k127_1656383_4	94624.Bpet4513	2.858e-209	688.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria,3T3EX@506|Alcaligenaceae	28216|Betaproteobacteria	E	Homoserine dehydrogenase, NAD binding domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
HKD3_k127_1656383_16	1100720.ALKN01000045_gene69	1.088e-107	387.0	COG5285@1|root,COG5285@2|Bacteria,1MWD5@1224|Proteobacteria,2VM24@28216|Betaproteobacteria,4ABN5@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.55	ko:K10674	ko00260,ko01120,map00260,map01120	-	R08050	RC00661	ko00000,ko00001,ko01000	-	-	-	PhyH
HKD3_k127_1656383_6	1265502.KB905958_gene235	1.362e-177	576.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJD4@28216|Betaproteobacteria,4AD48@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HKD3_k127_1656383_14	1265502.KB905958_gene236	2.512e-114	409.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,2VITU@28216|Betaproteobacteria,4ABQN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HKD3_k127_1656383_21	760117.JN27_15870	5.073e-86	291.0	COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,2VIDN@28216|Betaproteobacteria,472FE@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Bacterial transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	TetR,TetR_N
HKD3_k127_1656383_20	648757.Rvan_0462	4.981e-93	319.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria	1224|Proteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD3_k127_1656383_34	296591.Bpro_4024	1.974e-35	140.0	COG3937@1|root,COG3937@2|Bacteria,1RIXG@1224|Proteobacteria,2VT1J@28216|Betaproteobacteria,4ADWD@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM poly granule associated family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD3_k127_1656383_1	358220.C380_03070	4.019e-305	948.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,2VKRX@28216|Betaproteobacteria,4AB29@80864|Comamonadaceae	28216|Betaproteobacteria	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
HKD3_k127_1656383_26	1502852.FG94_04617	3.285e-57	215.0	COG1075@1|root,COG1075@2|Bacteria,1N3FV@1224|Proteobacteria,2WFKG@28216|Betaproteobacteria,4747N@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,PGAP1
HKD3_k127_1656383_2	1095769.CAHF01000022_gene391	3.01e-237	752.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,2VHUP@28216|Betaproteobacteria,4723S@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_1656383_35	760117.JN27_15845	8.031e-35	142.0	2DQ04@1|root,33466@2|Bacteria,1NA4M@1224|Proteobacteria,2VTGQ@28216|Betaproteobacteria,474JJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TAT_signal
HKD3_k127_1656383_27	522306.CAP2UW1_2233	8.564e-52	193.0	2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,2VS4A@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1656383_28	1217718.ALOU01000019_gene2759	1.156e-51	184.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,1K77M@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD3_k127_1656383_42	1562701.BBOF01000039_gene955	9.3e-16	84.0	COG2965@1|root,COG2965@2|Bacteria,1N98W@1224|Proteobacteria,2VVZ4@28216|Betaproteobacteria,1K8MD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Binds single-stranded DNA at the primosome assembly site (PAS)	priB	-	-	ko:K02686	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SSB
HKD3_k127_1656383_32	887898.HMPREF0551_0432	3.421e-40	150.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,1K8EX@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD3_k127_1656383_25	1121127.JAFA01000011_gene3851	2.877e-59	209.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,1K721@119060|Burkholderiaceae	28216|Betaproteobacteria	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD3_k127_1656383_41	864051.BurJ1DRAFT_2913	5.013e-17	81.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,1KJ8B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD3_k127_167646_11	342113.DM82_511	3.612e-09	61.0	COG0346@1|root,COG0346@2|Bacteria,1RD81@1224|Proteobacteria,2VQA3@28216|Betaproteobacteria,1K4QP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_3
HKD3_k127_167646_3	795666.MW7_1495	3.39e-99	332.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VK64@28216|Betaproteobacteria,1K0U3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	hpcH	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_167646_5	1123504.JQKD01000005_gene4741	5.443e-62	227.0	COG2230@1|root,COG2230@2|Bacteria,1QX5S@1224|Proteobacteria,2WHKW@28216|Betaproteobacteria,4AJZM@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_167646_4	1380391.JIAS01000015_gene179	1.588e-86	292.0	COG3467@1|root,COG3467@2|Bacteria,1MWQE@1224|Proteobacteria,2TR7J@28211|Alphaproteobacteria,2JS97@204441|Rhodospirillales	204441|Rhodospirillales	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD3_k127_167646_2	1095769.CAHF01000005_gene1582	4.916e-113	371.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,472KB@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_167646_7	757424.Hsero_4788	1.141e-43	168.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2VRSU@28216|Betaproteobacteria,474F4@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Lipocalin-like domain	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD3_k127_167646_8	1217708.F887_00792	1.486e-26	114.0	COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,1SF8E@1236|Gammaproteobacteria,3NNM0@468|Moraxellaceae	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_167646_1	292564.Cyagr_0222	1.286e-128	450.0	2BWQ7@1|root,33XD9@2|Bacteria,1GDXX@1117|Cyanobacteria,22RVZ@167375|Cyanobium	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_167646_6	180281.CPCC7001_1865	4.361e-56	214.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Peptidase_M48,TPR_16,TPR_2,TPR_8
HKD3_k127_167646_9	1286631.X805_35170	7.794e-21	108.0	COG2010@1|root,COG2010@2|Bacteria,1RDPD@1224|Proteobacteria,2VYFE@28216|Betaproteobacteria,1KP82@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_167646_0	420662.Mpe_A0341	4.436e-262	818.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria,1KNF6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HKD3_k127_167646_10	1238182.C882_3663	4.214e-10	60.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,2JP99@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_1737215_0	887898.HMPREF0551_0747	5.141e-320	995.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,1K0BK@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_1737215_4	1080067.BAZH01000008_gene77	3.98e-05	49.0	2AYT6@1|root,31QYG@2|Bacteria,1QNH4@1224|Proteobacteria,1TM2S@1236|Gammaproteobacteria,3WZPT@544|Citrobacter	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1737215_1	375286.mma_1530	1.541e-152	493.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,472K7@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD3_k127_1737215_2	887898.HMPREF0551_0745	3.229e-108	354.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,1K071@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD3_k127_1737215_3	1500894.JQNN01000001_gene1130	3.584e-104	342.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,4729D@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD3_k127_1751602_20	717785.HYPMC_1741	6.018e-41	156.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,3N99C@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_1751602_24	1357272.AVEO02000003_gene3728	1.27e-23	109.0	COG2931@1|root,COG2931@2|Bacteria,1NBPA@1224|Proteobacteria	1224|Proteobacteria	Q	Domain of unknown function (DUF4214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Peptidase_M10
HKD3_k127_1751602_16	196490.AUEZ01000022_gene860	6.2e-56	215.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2VF55@28211|Alphaproteobacteria,3K3QA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD3_k127_1751602_19	290400.Jann_3601	2.744e-43	176.0	28NRQ@1|root,2ZBQX@2|Bacteria,1RC0K@1224|Proteobacteria,2U5DZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1751602_4	1177179.A11A3_15092	1.702e-207	664.0	COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,1RQD3@1236|Gammaproteobacteria,1XHM1@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_1751602_14	335283.Neut_0144	5.216e-63	235.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2WA8I@28216|Betaproteobacteria,3733T@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_1751602_21	391626.OAN307_c26900	4.234e-40	169.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_1751602_8	114615.BRADO5757	2.454e-157	514.0	COG2124@1|root,COG2124@2|Bacteria,1N0ID@1224|Proteobacteria,2TT7V@28211|Alphaproteobacteria,3JQMQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Cytochrome P450	MA20_11175	-	-	ko:K21034	-	-	-	-	ko00000,ko00199	-	-	-	p450
HKD3_k127_1751602_5	1286093.C266_09639	3.191e-181	575.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,1K159@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD3_k127_1751602_15	365046.Rta_02070	1.21e-56	201.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,4ADXS@80864|Comamonadaceae	28216|Betaproteobacteria	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD3_k127_1751602_7	75379.Tint_0837	7.152e-164	523.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,1KJ4C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	pntAA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD3_k127_1751602_17	1265502.KB905937_gene2577	2.192e-46	168.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2VSM2@28216|Betaproteobacteria,4AEIA@80864|Comamonadaceae	28216|Betaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD3_k127_1751602_2	887898.HMPREF0551_1633	1.384e-241	761.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,1K2V7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD3_k127_1751602_11	864051.BurJ1DRAFT_0549	5.022e-94	315.0	COG1409@1|root,COG1409@2|Bacteria,1R4AZ@1224|Proteobacteria,2VIHN@28216|Betaproteobacteria,1KJHN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD3_k127_1751602_13	887898.HMPREF0551_1634	1.36e-64	227.0	COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,2W0P4@28216|Betaproteobacteria,1K2PW@119060|Burkholderiaceae	28216|Betaproteobacteria	U	UPF0056 inner membrane protein	mar	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD3_k127_1751602_22	887898.HMPREF0551_1636	6.112e-29	120.0	COG3671@1|root,COG3671@2|Bacteria,1N51H@1224|Proteobacteria,2VUKZ@28216|Betaproteobacteria,1KI8I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1751602_6	1095769.CAHF01000001_gene3495	4.44e-181	576.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,473PD@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Glycolate oxidase, iron-sulfur subunit	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
HKD3_k127_1751602_9	29581.BW37_01259	9.595e-134	434.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4725H@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
HKD3_k127_1751602_3	395019.Bmul_2652	1.203e-235	737.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,1K0Q5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	glcD	-	1.1.2.4,1.1.3.15,1.1.5.12	ko:K00102,ko:K00104,ko:K03777	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475,R00704,R11591	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_1751602_12	987059.RBXJA2T_08650	1.055e-86	321.0	COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,2VJ2A@28216|Betaproteobacteria,1KK3P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_1751602_1	742159.HMPREF0004_1571	2.341e-252	793.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VKNA@28216|Betaproteobacteria,3T5YS@506|Alcaligenaceae	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	aidB_1	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD3_k127_1751602_10	1532557.JL37_25480	1.16e-106	361.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2WFB8@28216|Betaproteobacteria,3T58Z@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_1751602_18	765912.Thimo_1678	3.137e-45	168.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1WYGS@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD3_k127_1751602_0	157783.LK03_10285	0.0	1180.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD3_k127_1751602_25	118173.KB235914_gene861	6.255e-14	74.0	COG1881@1|root,COG1881@2|Bacteria,1G1EC@1117|Cyanobacteria	1117|Cyanobacteria	S	YHYH protein	-	-	-	-	-	-	-	-	-	-	-	-	YHYH
HKD3_k127_1766221_3	296591.Bpro_2111	2.92e-141	453.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,4AADV@80864|Comamonadaceae	28216|Betaproteobacteria	S	peptidase dimerisation domain protein	-	-	3.5.1.32	ko:K01451	ko00360,map00360	-	R01424	RC00096,RC00162	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_1766221_2	1157708.KB907452_gene3928	1.811e-155	497.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHEF@28216|Betaproteobacteria,4ABQ2@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD3_k127_1766221_1	360910.BAV2890	9.736e-173	552.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VM4Z@28216|Betaproteobacteria,3T8WW@506|Alcaligenaceae	28216|Betaproteobacteria	S	Metal-dependent amidase aminoacylase carboxypeptidase	yxeP_2	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_1766221_0	1265502.KB905948_gene994	1.557e-255	800.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,4ABBW@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_1766221_4	477184.KYC_07466	1.172e-136	441.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VIN2@28216|Betaproteobacteria,3T5VQ@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC_1	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD3_k127_1766221_5	1205680.CAKO01000006_gene3170	2.828e-49	177.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales	204441|Rhodospirillales	EP	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD3_k127_1839486_6	591158.SSMG_07343	1.316e-25	110.0	COG3631@1|root,COG3631@2|Bacteria,2I4MG@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_1839486_2	1265313.HRUBRA_02018	2.454e-94	339.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,1RY55@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the ribose-phosphate pyrophosphokinase family	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
HKD3_k127_1839486_1	1116472.MGMO_145c00050	1.691e-212	671.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1XEM6@135618|Methylococcales	135618|Methylococcales	F	Thymidine phosphorylase	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD3_k127_1839486_5	312153.Pnuc_2054	1.172e-30	126.0	COG2335@1|root,COG2335@2|Bacteria,1MZ8G@1224|Proteobacteria,2VUKM@28216|Betaproteobacteria,1K8AB@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM CHRD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
HKD3_k127_1839486_3	76114.ebA342	3.072e-52	188.0	COG0537@1|root,COG0537@2|Bacteria,1PE1E@1224|Proteobacteria,2WA47@28216|Betaproteobacteria,2KZD4@206389|Rhodocyclales	206389|Rhodocyclales	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HKD3_k127_1839486_4	1126627.BAWE01000005_gene6179	6.882e-31	125.0	COG5470@1|root,COG5470@2|Bacteria,1Q484@1224|Proteobacteria,2UCEX@28211|Alphaproteobacteria,3K0KP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_1839486_0	62928.azo2989	0.0	1152.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,2KV5J@206389|Rhodocyclales	206389|Rhodocyclales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HKD3_k127_1895216_1	887898.HMPREF0551_1719	2.328e-223	700.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,1K36E@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD3_k127_1895216_4	93220.LV28_11270	1.108e-67	239.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,1K029@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cytochrome c assembly protein	ypjD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD3_k127_1895216_6	1454004.AW11_02288	6.833e-08	64.0	2EHK0@1|root,33BBV@2|Bacteria,1NGIK@1224|Proteobacteria,2VXN8@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	-
HKD3_k127_1895216_3	887898.HMPREF0551_1717	1.497e-109	376.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,2WH69@28216|Betaproteobacteria	28216|Betaproteobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
HKD3_k127_1895216_2	204773.HEAR2772	5.631e-166	542.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,472RM@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Sigma-54 interaction domain	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD3_k127_1895216_5	999541.bgla_1g05320	1.575e-62	239.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,1K2HB@119060|Burkholderiaceae	28216|Betaproteobacteria	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	ampD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
HKD3_k127_1895216_0	1095769.CAHF01000014_gene2876	1.739e-304	947.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,472GD@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD3_k127_1920232_2	595537.Varpa_5465	2.176e-109	366.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VMJZ@28216|Betaproteobacteria,4AAV4@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_1920232_1	243233.MCA1213	4.009e-250	786.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD3_k127_1920232_0	1207063.P24_13378	6.271e-258	804.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2JRIA@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD3_k127_1920232_4	1207063.P24_13383	3.855e-72	279.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VGB7@28211|Alphaproteobacteria,2JYRY@204441|Rhodospirillales	204441|Rhodospirillales	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
HKD3_k127_1920232_5	426114.THI_0947	9.446e-45	171.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2VR7A@28216|Betaproteobacteria,1KNN0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD3_k127_1920232_3	1123401.JHYQ01000013_gene687	2.947e-109	373.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RNVP@1236|Gammaproteobacteria,461IT@72273|Thiotrichales	72273|Thiotrichales	S	Flavocytochrome c sulphide dehydrogenase, flavin-binding	-	-	-	-	-	-	-	-	-	-	-	-	FCSD-flav_bind,Pyr_redox_2
HKD3_k127_1920232_6	1123399.AQVE01000024_gene2817	3.516e-13	76.0	COG2863@1|root,COG2863@2|Bacteria,1N7NU@1224|Proteobacteria,1SH3Q@1236|Gammaproteobacteria,463A7@72273|Thiotrichales	72273|Thiotrichales	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1920232_7	1286631.X805_00530	4.526e-11	63.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,1KKSC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_2086861_24	1248917.ANFX01000045_gene1294	3.606e-20	92.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,2K212@204457|Sphingomonadales	204457|Sphingomonadales	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD3_k127_2086861_12	338969.Rfer_0443	5.193e-117	381.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2VJ19@28216|Betaproteobacteria,4ABCT@80864|Comamonadaceae	28216|Betaproteobacteria	G	Belongs to the hyi family	hyi	-	5.3.1.22,5.3.1.35	ko:K01816,ko:K22131	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD3_k127_2086861_8	1095769.CAHF01000013_gene3314	2.953e-144	469.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,472XW@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD3_k127_2086861_22	795666.MW7_3525	8.975e-76	273.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2VQ1I@28216|Betaproteobacteria,1K2BA@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD3_k127_2086861_10	94624.Bpet3594	1.344e-137	448.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2VI6V@28216|Betaproteobacteria,3T1G3@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD3_k127_2086861_20	887898.HMPREF0551_0251	2.001e-88	306.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,1K013@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	rimN	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD3_k127_2086861_14	1205680.CAKO01000029_gene5220	2.106e-107	375.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,2JRF8@204441|Rhodospirillales	204441|Rhodospirillales	E	Beta-eliminating lyase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD3_k127_2086861_18	365046.Rta_22390	1.252e-90	305.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VHGT@28216|Betaproteobacteria,4ACSD@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_2086861_19	62928.azo3047	5.966e-89	301.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKUM@28216|Betaproteobacteria,2KY9I@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_2086861_16	159087.Daro_2770	3.625e-98	345.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VK9Y@28216|Betaproteobacteria,2KV1M@206389|Rhodocyclales	206389|Rhodocyclales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_2086861_11	296591.Bpro_2986	3.394e-118	388.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,4AB0U@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_2086861_6	76114.ebA5303	1.902e-152	505.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,2KY62@206389|Rhodocyclales	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_2086861_21	1121920.AUAU01000006_gene299	4.445e-82	283.0	COG1073@1|root,COG1073@2|Bacteria,3Y8AH@57723|Acidobacteria	57723|Acidobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD3_k127_2086861_23	1380394.JADL01000003_gene5179	1.585e-72	253.0	COG0703@1|root,COG1396@1|root,COG0703@2|Bacteria,COG1396@2|Bacteria,1MX66@1224|Proteobacteria,2TQWU@28211|Alphaproteobacteria,2JSJ6@204441|Rhodospirillales	204441|Rhodospirillales	EK	Shikimate kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,SKI
HKD3_k127_2086861_13	1488328.JMCL01000133_gene1732	1.044e-113	383.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_2086861_4	1488328.JMCL01000099_gene4302	2.483e-169	548.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015318,GO:0015679,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1990169	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	iECSF_1327.ECSF_0504	CusF_Ec,HlyD_D23,HlyD_D4
HKD3_k127_2086861_0	440512.C211_05331	0.0	1660.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015673,GO:0015679,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0031224,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0071944,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1902601,GO:1990169	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iB21_1397.B21_00525,iECBD_1354.ECBD_3087,iECB_1328.ECB_00536,iECD_1391.ECD_00536	ACR_tran
HKD3_k127_2086861_2	1144310.PMI07_002946	3.393e-187	597.0	COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2UQQQ@28211|Alphaproteobacteria,4BB6V@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Glucose inhibited division protein A	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HKD3_k127_2086861_15	1156919.QWC_02928	7.835e-105	356.0	COG3181@1|root,COG3181@2|Bacteria,1QH5Z@1224|Proteobacteria,2VPDA@28216|Betaproteobacteria,3T2D4@506|Alcaligenaceae	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_2086861_17	1175306.GWL_27140	1.238e-96	323.0	COG1028@1|root,COG1028@2|Bacteria,1QIZD@1224|Proteobacteria,2VNCS@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_2086861_5	395495.Lcho_3575	4.119e-166	532.0	COG1744@1|root,COG1744@2|Bacteria,1MVU5@1224|Proteobacteria,2VKZI@28216|Betaproteobacteria,1KKIH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	basic membrane	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
HKD3_k127_2086861_3	983917.RGE_45800	8.233e-179	591.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2WGJY@28216|Betaproteobacteria,1KIYS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD3_k127_2086861_7	1003200.AXXA_10725	1.642e-148	484.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VHXA@28216|Betaproteobacteria,3T2YP@506|Alcaligenaceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD3_k127_2086861_9	358220.C380_12885	1.895e-140	453.0	COG1079@1|root,COG1079@2|Bacteria,1NAYV@1224|Proteobacteria,2VJ78@28216|Betaproteobacteria,4AAR8@80864|Comamonadaceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD3_k127_2086861_1	62928.azo3769	3.293e-217	681.0	COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2VMF2@28216|Betaproteobacteria	28216|Betaproteobacteria	F	cytosine deaminase	codA	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD3_k127_216161_6	1162668.LFE_0661	1.148e-33	139.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	pyrD	-	1.3.1.14	ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,DHO_dh,NAD_binding_1
HKD3_k127_216161_1	543728.Vapar_1858	1.671e-197	623.0	COG0673@1|root,COG0673@2|Bacteria,1PYTN@1224|Proteobacteria,2VKKE@28216|Betaproteobacteria,4AA47@80864|Comamonadaceae	28216|Betaproteobacteria	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD3_k127_216161_2	420324.KI912020_gene7471	8.684e-177	582.0	COG0329@1|root,COG0329@2|Bacteria,1MV7E@1224|Proteobacteria,2TTT5@28211|Alphaproteobacteria,1JX6U@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EM	Protein of unknown function (DUF993)	MA20_16880	-	-	-	-	-	-	-	-	-	-	-	DUF993
HKD3_k127_216161_4	595537.Varpa_3964	1.791e-148	473.0	COG1082@1|root,COG1082@2|Bacteria,1Q173@1224|Proteobacteria,2VK1Z@28216|Betaproteobacteria,4AAG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD3_k127_216161_0	1411123.JQNH01000001_gene3242	1.809e-235	736.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	MA20_08220	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD3_k127_216161_3	365046.Rta_25050	8.764e-159	510.0	COG3970@1|root,COG3970@2|Bacteria,1MVA2@1224|Proteobacteria,2VIXV@28216|Betaproteobacteria,4AC05@80864|Comamonadaceae	28216|Betaproteobacteria	S	fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD3_k127_216161_5	983917.RGE_32270	1.323e-43	163.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,1KJEY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	rosB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HKD3_k127_233404_15	1123367.C666_16160	3.366e-47	177.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HKD3_k127_233404_14	381666.H16_A3155	9.385e-49	192.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,1K0IS@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HKD3_k127_233404_6	1031711.RSPO_c00741	8.994e-104	346.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2VI0Q@28216|Betaproteobacteria,1K08C@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD3_k127_233404_13	795666.MW7_1171	6.131e-56	199.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,1K70H@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD3_k127_233404_10	1095769.CAHF01000009_gene1427	2.037e-63	222.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,4743Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD3_k127_233404_3	29581.BW37_05187	3.139e-162	518.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,472F0@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD3_k127_233404_0	1123368.AUIS01000003_gene1787	0.0	1023.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2NCC6@225057|Acidithiobacillales	1236|Gammaproteobacteria	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD3_k127_233404_8	266264.Rmet_2689	2.329e-82	283.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2VIU0@28216|Betaproteobacteria,1K06S@119060|Burkholderiaceae	28216|Betaproteobacteria	H	riboflavin synthase alpha	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD3_k127_233404_5	1192124.LIG30_3601	3.422e-152	493.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2VI9P@28216|Betaproteobacteria,1JZMJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD3_k127_233404_17	640512.BC1003_0853	3.048e-27	121.0	COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,1K1PA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF541)	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
HKD3_k127_233404_1	1095769.CAHF01000014_gene2918	4.719e-233	750.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VIEX@28216|Betaproteobacteria,4727V@75682|Oxalobacteraceae	28216|Betaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvG	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_233404_9	93220.LV28_06815	6.063e-66	228.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2VR9P@28216|Betaproteobacteria,1K2EP@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD3_k127_233404_16	1283300.ATXB01000001_gene2402	9.177e-45	169.0	COG4636@1|root,COG4636@2|Bacteria,1RJC2@1224|Proteobacteria,1S7B0@1236|Gammaproteobacteria,1XF6F@135618|Methylococcales	135618|Methylococcales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD3_k127_233404_2	365046.Rta_15320	1.575e-224	702.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2VJ4F@28216|Betaproteobacteria,4AABM@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD3_k127_233404_11	388051.AUFE01000035_gene4012	3.275e-60	218.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,1K3KI@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD3_k127_233404_7	1304883.KI912532_gene203	1.817e-93	325.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,2KUB9@206389|Rhodocyclales	206389|Rhodocyclales	S	Phospholipid-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD3_k127_233404_12	1095769.CAHF01000001_gene3533	1.276e-56	214.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,474FN@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD3_k127_233404_4	388051.AUFE01000035_gene4009	1.087e-153	489.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,1JZQB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,S4_2,tRNA-synt_1b
HKD3_k127_2452124_6	887898.HMPREF0551_2548	7.497e-45	163.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,1JZTW@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Glutathione S-transferase	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD3_k127_2452124_7	1304883.KI912532_gene1724	7.826e-39	152.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,2KX0Y@206389|Rhodocyclales	206389|Rhodocyclales	S	stringent starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
HKD3_k127_2452124_10	398767.Glov_2384	3.67e-13	78.0	2ATWF@1|root,31JFP@2|Bacteria,1RK55@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2452124_1	338966.Ppro_0405	8.479e-108	361.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,43T7X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_2452124_0	243233.MCA1632	1.065e-135	474.0	COG1196@1|root,COG3264@1|root,COG1196@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1XE6E@135618|Methylococcales	135618|Methylococcales	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD3_k127_2452124_4	864051.BurJ1DRAFT_3805	7.136e-49	187.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2VNUN@28216|Betaproteobacteria,1KKKC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_2452124_8	1198452.Jab_1c05800	2.715e-33	135.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,474RA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HKD3_k127_2452124_3	1121378.KB899779_gene1579	6.466e-58	208.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD3_k127_2452124_9	887062.HGR_14879	4.348e-14	78.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,4ADXE@80864|Comamonadaceae	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_2452124_2	1005048.CFU_3901	3.601e-84	282.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,4723E@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD3_k127_2452124_5	887898.HMPREF0551_2557	6.488e-45	182.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2VSCX@28216|Betaproteobacteria,1K7NP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
HKD3_k127_2455616_3	1265502.KB905948_gene994	2.975e-92	305.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,4ABBW@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_2455616_2	477184.KYC_07466	1.19e-133	433.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VIN2@28216|Betaproteobacteria,3T5VQ@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC_1	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD3_k127_2455616_0	1156919.QWC_22739	1.052e-164	523.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,3T2XD@506|Alcaligenaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD3_k127_2455616_1	331869.BAL199_04204	2.152e-143	479.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,4BPJH@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD3_k127_2455616_4	1095769.CAHF01000001_gene3563	9.106e-68	241.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,2VRDD@28216|Betaproteobacteria,472PX@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HKD3_k127_2455616_5	1235457.C404_19315	1.499e-23	113.0	2DF7Q@1|root,33391@2|Bacteria,1NB8A@1224|Proteobacteria,2VWDS@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2481920_4	1380394.JADL01000008_gene3474	1.336e-118	387.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2JPGD@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HKD3_k127_2481920_1	1231391.AMZF01000046_gene938	1.291e-225	726.0	COG2816@1|root,COG2816@2|Bacteria,1MV1F@1224|Proteobacteria,2VMHT@28216|Betaproteobacteria	28216|Betaproteobacteria	L	COG1180 Pyruvate-formate lyase-activating enzyme	-	-	1.3.7.1	ko:K20449	ko00760,ko01120,map00760,map01120	-	R03164	RC02422	ko00000,ko00001,ko01000	-	-	-	-
HKD3_k127_2481920_9	1157708.KB907472_gene1286	1.896e-76	286.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,2VKJ0@28216|Betaproteobacteria,4AC25@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	ApbE
HKD3_k127_2481920_8	296591.Bpro_4066	2.861e-83	294.0	2DBCJ@1|root,2Z8E3@2|Bacteria,1MXMX@1224|Proteobacteria,2VMBT@28216|Betaproteobacteria,4AC4H@80864|Comamonadaceae	28216|Betaproteobacteria	S	Amino acid synthesis	-	-	-	-	-	-	-	-	-	-	-	-	AA_synth
HKD3_k127_2481920_7	887062.HGR_10050	3.327e-94	326.0	28I63@1|root,2Z897@2|Bacteria,1N3VY@1224|Proteobacteria,2VJCE@28216|Betaproteobacteria,4A9PU@80864|Comamonadaceae	28216|Betaproteobacteria	S	Amino acid synthesis	-	-	-	-	-	-	-	-	-	-	-	-	AA_synth
HKD3_k127_2481920_3	266265.Bxe_B0664	1.786e-194	613.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2VKVZ@28216|Betaproteobacteria,1K3PS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_2481920_0	864073.HFRIS_023132	7.989e-275	857.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_2481920_5	1472716.KBK24_0138150	1.165e-99	358.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VI2N@28216|Betaproteobacteria,1K414@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_2481920_6	1472716.KBK24_0138145	2.769e-96	340.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VI3W@28216|Betaproteobacteria,1K1QP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_2481920_2	1169143.KB911035_gene2188	4.835e-209	655.0	COG0402@1|root,COG0402@2|Bacteria,1MVMR@1224|Proteobacteria,2VMY2@28216|Betaproteobacteria,1K4KS@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.18	ko:K15358	ko00760,ko01120,map00760,map01120	-	R07984	RC01933	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD3_k127_2497309_1	76114.ebA1206	7.681e-189	598.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJ2@28216|Betaproteobacteria,2KUZM@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_2497309_5	1410620.SHLA_29c000680	4.311e-153	499.0	COG5441@1|root,COG5441@2|Bacteria,1MX45@1224|Proteobacteria,2TUHA@28211|Alphaproteobacteria,4B8FU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
HKD3_k127_2497309_12	864051.BurJ1DRAFT_4467	2.168e-16	81.0	2DR3J@1|root,33A0M@2|Bacteria,1NMH8@1224|Proteobacteria,2VZ1I@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2497309_8	365046.Rta_10030	1.291e-108	358.0	COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2VMG6@28216|Betaproteobacteria,4ABN6@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_2497309_11	448385.sce0906	3.29e-59	213.0	COG0122@1|root,COG0350@1|root,COG0122@2|Bacteria,COG0350@2|Bacteria,1MVF7@1224|Proteobacteria,43ARM@68525|delta/epsilon subdivisions,2X65K@28221|Deltaproteobacteria,2Z392@29|Myxococcales	28221|Deltaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,HhH-GPD
HKD3_k127_2497309_3	1454004.AW11_01484	1.979e-166	530.0	COG0031@1|root,COG0031@2|Bacteria,1MUR6@1224|Proteobacteria,2VJEW@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_2497309_0	1187851.A33M_2746	3.076e-285	892.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,3FCUA@34008|Rhodovulum	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase N terminal	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
HKD3_k127_2497309_10	522306.CAP2UW1_1998	1.177e-76	266.0	29VND@1|root,30H5P@2|Bacteria,1RBVN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2497309_9	1267534.KB906760_gene1239	7.933e-105	355.0	COG4325@1|root,COG4325@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD3_k127_2497309_13	1144342.PMI40_04198	5.182e-12	73.0	2CHK6@1|root,333A9@2|Bacteria,1N9I7@1224|Proteobacteria,2VWH1@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2497309_7	1134912.AJTV01000023_gene2883	1.875e-125	406.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,36ZK0@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_2497309_6	322710.Avin_44030	8.429e-147	497.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD3_k127_2497309_4	1538295.JY96_07450	6.595e-155	506.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,1KJ9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD3_k127_2497309_2	381666.H16_B1632	2.336e-172	553.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
HKD3_k127_256867_3	477184.KYC_05686	1.578e-102	366.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJ0Q@28216|Betaproteobacteria,3T2Y1@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_256867_1	987059.RBXJA2T_17162	2.34e-292	913.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,1KJ66@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD3_k127_256867_4	640081.Dsui_1107	1.165e-85	289.0	COG0664@1|root,COG0664@2|Bacteria,1MUHT@1224|Proteobacteria,2VI43@28216|Betaproteobacteria,2KY92@206389|Rhodocyclales	206389|Rhodocyclales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_256867_5	1538295.JY96_07100	1.468e-77	264.0	COG0500@1|root,COG0500@2|Bacteria,1QVHC@1224|Proteobacteria,2VS83@28216|Betaproteobacteria,1KKW7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	TPMT
HKD3_k127_256867_2	1297865.APJD01000026_gene2419	1.126e-119	405.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,3JUBU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	MA20_34330	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD3_k127_256867_6	497321.C664_10662	1.016e-68	243.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,2KXUE@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HKD3_k127_256867_0	1265502.KB905934_gene3292	0.0	1500.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,4AC69@80864|Comamonadaceae	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD3_k127_2572844_0	1095769.CAHF01000011_gene2576	0.0	1273.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,472V3@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD3_k127_2572844_1	667632.KB890172_gene4024	3.379e-190	601.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,1K3MB@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD3_k127_2572844_6	1218076.BAYB01000006_gene1082	3.199e-132	438.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2VI9N@28216|Betaproteobacteria,1K17T@119060|Burkholderiaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_2572844_4	388051.AUFE01000009_gene1746	6.979e-144	460.0	COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria,2VHGX@28216|Betaproteobacteria,1KGMZ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_2572844_5	1123504.JQKD01000002_gene3566	5.102e-140	453.0	COG0715@1|root,COG0715@2|Bacteria,1MVZE@1224|Proteobacteria,2VJ88@28216|Betaproteobacteria,4A9W3@80864|Comamonadaceae	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD3_k127_2572844_2	1458357.BG58_04170	3.33e-171	557.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1K17R@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	frc_13	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD3_k127_2572844_7	1095769.CAHF01000010_gene1091	2.101e-91	305.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2VJVJ@28216|Betaproteobacteria,4724K@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HKD3_k127_2572844_8	640511.BC1002_1396	7.46e-50	184.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2VSJ2@28216|Betaproteobacteria,1K7N7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD3_k127_2572844_3	360910.BAV0914	7.391e-169	549.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,3T1S4@506|Alcaligenaceae	28216|Betaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
HKD3_k127_2593114_1	420662.Mpe_A0903	7.746e-281	866.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1KJWN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD3_k127_2593114_0	1205680.CAKO01000010_gene4023	0.0	1129.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,2JQ9T@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_2593114_8	887898.HMPREF0551_1996	5.938e-21	102.0	COG5490@1|root,COG5490@2|Bacteria,1R4SV@1224|Proteobacteria,2VQP2@28216|Betaproteobacteria,1JZMD@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM phasin family protein	phaP	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD3_k127_2593114_4	1268622.AVS7_00792	5.955e-79	280.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKYM@28216|Betaproteobacteria,4AA9N@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_2593114_5	1227349.C170_10450	1.62e-36	149.0	COG0454@1|root,COG0456@2|Bacteria,1VJPU@1239|Firmicutes,4HG6J@91061|Bacilli,277DW@186822|Paenibacillaceae	91061|Bacilli	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD3_k127_2593114_2	358220.C380_02830	9.062e-250	780.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,4A9MZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_2593114_7	589865.DaAHT2_2130	2.517e-21	100.0	COG0517@1|root,COG0517@2|Bacteria,1QQRM@1224|Proteobacteria,42TVT@68525|delta/epsilon subdivisions,2WQBQ@28221|Deltaproteobacteria,2MNSD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_2593114_3	864051.BurJ1DRAFT_1726	1.435e-242	764.0	COG0807@1|root,COG0807@2|Bacteria,1PQ5Y@1224|Proteobacteria,2VJ66@28216|Betaproteobacteria,1KJ1N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	GTP cyclohydrolase N terminal	ribA	-	-	-	-	-	-	-	-	-	-	-	GTP_CH_N,GTP_cyclohydro2
HKD3_k127_2593114_6	864051.BurJ1DRAFT_1725	7.711e-30	127.0	COG0807@1|root,COG0807@2|Bacteria,1MWUM@1224|Proteobacteria,2VJRX@28216|Betaproteobacteria,1KJRK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Protein of unknown function (DUF1688)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1688
HKD3_k127_2599252_5	1265502.KB905929_gene2208	1.011e-145	468.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VJHE@28216|Betaproteobacteria,4ACC4@80864|Comamonadaceae	28216|Betaproteobacteria	S	N-terminal domain of oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HKD3_k127_2599252_3	1117647.M5M_18065	1.891e-151	505.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,1RPHS@1236|Gammaproteobacteria,1J54J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Fatty acid desaturase	alkB1	GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016705,GO:0016713,GO:0018685,GO:0043446,GO:0043448,GO:0044237,GO:0044248,GO:0055114,GO:0071704,GO:1901575	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
HKD3_k127_2599252_8	383372.Rcas_0914	1.855e-108	368.0	COG1024@1|root,COG1024@2|Bacteria,2G6BP@200795|Chloroflexi,376M6@32061|Chloroflexia	32061|Chloroflexia	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_2599252_7	887898.HMPREF0551_1355	1.821e-134	452.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,1K1U1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD3_k127_2599252_11	887898.HMPREF0551_1356	1.093e-79	292.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,2VN9P@28216|Betaproteobacteria,1K566@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD3_k127_2599252_2	887898.HMPREF0551_1357	2.01e-203	653.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,1K1F2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HKD3_k127_2599252_9	887898.HMPREF0551_1358	1.012e-88	319.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2VJGZ@28216|Betaproteobacteria,1JZZ7@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Lytic murein transglycosylase B	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
HKD3_k127_2599252_14	640081.Dsui_2899	7.092e-64	233.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,2KVQX@206389|Rhodocyclales	206389|Rhodocyclales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_2599252_15	1523503.JPMY01000002_gene3992	1.411e-54	215.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria	1224|Proteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HKD3_k127_2599252_4	264198.Reut_A2560	2.156e-149	494.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,1K4BM@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_2599252_6	1097668.BYI23_A003640	3.574e-137	444.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,1JZPC@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR family	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_2599252_12	1500894.JQNN01000001_gene3320	2.825e-76	268.0	COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,2VJI2@28216|Betaproteobacteria,472ZP@75682|Oxalobacteraceae	28216|Betaproteobacteria	EJ	Belongs to the asparaginase 1 family	ansB	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD3_k127_2599252_13	1500894.JQNN01000001_gene516	1.149e-68	246.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2VH7M@28216|Betaproteobacteria,478PT@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
HKD3_k127_2599252_1	292415.Tbd_0469	2.449e-247	786.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2VHE8@28216|Betaproteobacteria,1KRET@119069|Hydrogenophilales	119069|Hydrogenophilales	L	RecG wedge domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD3_k127_2599252_16	1385517.N800_15280	1.164e-45	169.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1X6CE@135614|Xanthomonadales	135614|Xanthomonadales	J	endoribonuclease	yjgF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_2599252_10	1121033.AUCF01000001_gene1954	1.291e-80	282.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,2JPPZ@204441|Rhodospirillales	204441|Rhodospirillales	S	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
HKD3_k127_2599252_17	94624.Bpet0910	2.964e-17	89.0	COG2314@1|root,COG2314@2|Bacteria,1PKJT@1224|Proteobacteria,2W8VH@28216|Betaproteobacteria,3T4FH@506|Alcaligenaceae	28216|Betaproteobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
HKD3_k127_2599252_0	1247649.D560_0985	0.0	1013.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD3_k127_2623471_16	883126.HMPREF9710_04523	2.938e-92	333.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4735B@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_2623471_11	639283.Snov_4292	4.44e-137	456.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria,3EY42@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Mannitol dehydrogenase Rossmann domain	uxuB	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
HKD3_k127_2623471_2	561175.KB894094_gene1906	7.869e-200	634.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria	201174|Actinobacteria	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD3_k127_2623471_15	94624.Bpet3948	8.457e-122	404.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,3T6V0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	idnD	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_2623471_8	296591.Bpro_3964	1.762e-156	499.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2VME7@28216|Betaproteobacteria,4AASE@80864|Comamonadaceae	28216|Betaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_2623471_18	365046.Rta_09000	7.242e-55	201.0	COG3090@1|root,COG3090@2|Bacteria,1R7TV@1224|Proteobacteria,2VPJP@28216|Betaproteobacteria,4ADJ5@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Tripartite ATP-independent periplasmic transporter, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_2623471_3	1504672.669784961	1.302e-181	581.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4AA1X@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_2623471_4	864051.BurJ1DRAFT_3905	1.476e-174	555.0	COG4948@1|root,COG4948@2|Bacteria,1Q9Q7@1224|Proteobacteria,2W9AP@28216|Betaproteobacteria,1KP04@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD3_k127_2623471_0	358220.C380_01240	5.785e-230	715.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2VIVU@28216|Betaproteobacteria,4A9N6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	4-hydroxybenzoate 3-monooxygenase	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HKD3_k127_2623471_20	1120999.JONM01000004_gene3571	2.154e-44	167.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria,2KRGU@206351|Neisseriales	206351|Neisseriales	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD3_k127_2623471_5	1121033.AUCF01000021_gene2847	1.013e-167	539.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2U4I6@28211|Alphaproteobacteria,2JRIG@204441|Rhodospirillales	204441|Rhodospirillales	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD3_k127_2623471_13	388051.AUFE01000016_gene5787	3.018e-131	452.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VI23@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_2623471_1	1504672.669784960	1.105e-216	683.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,4AB17@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	uxaA	-	4.2.1.7,4.4.1.24	ko:K01685,ko:K16846	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
HKD3_k127_2623471_9	941449.dsx2_2976	1.501e-147	483.0	COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,42PC9@68525|delta/epsilon subdivisions,2WKA4@28221|Deltaproteobacteria,2M9QR@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
HKD3_k127_2623471_10	497321.C664_12845	2.627e-145	511.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VS5R@28216|Betaproteobacteria,2KXAU@206389|Rhodocyclales	206389|Rhodocyclales	M	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235,RHS,RHS_repeat
HKD3_k127_2623471_17	1117647.M5M_15850	1.6e-65	240.0	COG2271@1|root,COG2271@2|Bacteria,1R9FF@1224|Proteobacteria,1RRG0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_2623471_12	324602.Caur_2084	1.226e-136	450.0	COG0076@1|root,COG0076@2|Bacteria,2GAD1@200795|Chloroflexi,376VF@32061|Chloroflexia	32061|Chloroflexia	E	PFAM aminotransferase class V	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HKD3_k127_2623471_6	395019.Bmul_2799	2.06e-166	536.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2VISR@28216|Betaproteobacteria,1K327@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HKD3_k127_2623471_7	1265502.KB905938_gene2497	5.079e-164	526.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,4AA8G@80864|Comamonadaceae	28216|Betaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD3_k127_2623471_21	365046.Rta_29110	2.732e-41	153.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,4AEWJ@80864|Comamonadaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD3_k127_2623471_19	887898.HMPREF0551_1760	7.392e-48	176.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,1K7RK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD3_k127_2623471_14	859657.RPSI07_0684	3.281e-131	432.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,1K1XM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD3_k127_264055_3	1158292.JPOE01000002_gene3676	5.491e-119	386.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,1KJQF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD3_k127_264055_7	292459.STH595	4.899e-12	78.0	2DR9X@1|root,33AUW@2|Bacteria	2|Bacteria	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
HKD3_k127_264055_6	887898.HMPREF0551_0298	2.366e-29	120.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,1K9EQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD3_k127_264055_1	1268622.AVS7_00631	1.894e-179	576.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,4A9MB@80864|Comamonadaceae	28216|Betaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD3_k127_264055_5	1000565.METUNv1_02974	1.185e-80	297.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,2KUUS@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD3_k127_264055_4	876269.ARWA01000001_gene2005	1.823e-106	354.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,3NC01@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	MA20_20705	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_264055_2	522306.CAP2UW1_3401	5.379e-178	569.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD3_k127_264055_0	331869.BAL199_15903	3.08e-209	664.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,4BRUQ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Flavin-binding monooxygenase-like	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
HKD3_k127_2651485_12	1000565.METUNv1_02769	1.656e-92	321.0	COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,2VHIB@28216|Betaproteobacteria,2KU6H@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2331
HKD3_k127_2651485_11	1304883.KI912532_gene2488	2.931e-94	312.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VH4A@28216|Betaproteobacteria,2KVAS@206389|Rhodocyclales	206389|Rhodocyclales	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD3_k127_2651485_20	887898.HMPREF0551_1191	2.3e-42	168.0	COG0745@1|root,COG0745@2|Bacteria	887898.HMPREF0551_1191|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2651485_21	1144342.PMI40_03163	1.719e-31	126.0	COG0454@1|root,COG0456@2|Bacteria,1N7JM@1224|Proteobacteria,2VU1F@28216|Betaproteobacteria,474TU@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Protein of unknown function (DUF3579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3579
HKD3_k127_2651485_3	397945.Aave_1164	1.101e-174	561.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,4A9QQ@80864|Comamonadaceae	28216|Betaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_2651485_4	305700.B447_00255	1.662e-165	525.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,2KV71@206389|Rhodocyclales	206389|Rhodocyclales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD3_k127_2651485_0	159087.Daro_0222	5.257e-302	939.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,2VKWB@28216|Betaproteobacteria,2KVQ3@206389|Rhodocyclales	206389|Rhodocyclales	J	COG0480 Translation elongation factors (GTPases)	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD3_k127_2651485_10	1000565.METUNv1_03022	6.64e-107	353.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2WEGN@28216|Betaproteobacteria,2KVA1@206389|Rhodocyclales	206389|Rhodocyclales	P	Part of the ABC transporter complex LolCDE involved in the translocation of	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD3_k127_2651485_5	1000565.METUNv1_03021	2.825e-163	526.0	COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,2VHS2@28216|Betaproteobacteria,2KVZT@206389|Rhodocyclales	206389|Rhodocyclales	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD3_k127_2651485_9	1000565.METUNv1_03020	4.875e-108	377.0	COG1566@1|root,COG1566@2|Bacteria,1QW95@1224|Proteobacteria,2WI8S@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2
HKD3_k127_2651485_6	264198.Reut_B5233	3.444e-147	473.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI98@28216|Betaproteobacteria,1K1TV@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldo/keto reductase family	mocA	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_2651485_22	296591.Bpro_4892	1.666e-24	111.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,2VRMP@28216|Betaproteobacteria,4AHB3@80864|Comamonadaceae	28216|Betaproteobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_2651485_16	309807.SRU_2488	6.883e-76	271.0	COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,1FK2H@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_2651485_18	1049564.TevJSym_ar00540	8.945e-64	244.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,1J4RT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD3_k127_2651485_7	420662.Mpe_A1234	1.424e-146	475.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1KJXY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD3_k127_2651485_2	1122236.KB905141_gene762	3.545e-200	676.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,2KKKM@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD3_k127_2651485_1	62928.azo3185	3.446e-229	728.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,2KUGP@206389|Rhodocyclales	206389|Rhodocyclales	S	ABC transporter	abcZ	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD3_k127_2651485_19	1123487.KB892868_gene1151	2.888e-43	182.0	COG0454@1|root,COG0456@2|Bacteria,1RH71@1224|Proteobacteria,2VS9R@28216|Betaproteobacteria,2KWSS@206389|Rhodocyclales	206389|Rhodocyclales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_2651485_15	272560.BPSL0867	2.39e-77	261.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,1K1JA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the UPF0234 family	yajQ	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HKD3_k127_2651485_8	765911.Thivi_1401	3.079e-135	443.0	COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,1RP0S@1236|Gammaproteobacteria,1WXWV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the sodium-dependent transport of glutamate	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HKD3_k127_2651485_17	1123392.AQWL01000003_gene118	7.247e-71	247.0	COG2823@1|root,COG2823@2|Bacteria,1RFX5@1224|Proteobacteria,2VRR5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	BON domain	osmY	-	-	-	-	-	-	-	-	-	-	-	BON
HKD3_k127_2651485_14	330214.NIDE1758	3.351e-88	296.0	COG1814@1|root,COG1814@2|Bacteria,3J16V@40117|Nitrospirae	40117|Nitrospirae	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD3_k127_2651485_13	1158292.JPOE01000002_gene3146	7.129e-91	308.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,1KKCP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SbmA/BacA-like family	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
HKD3_k127_2690895_2	1005048.CFU_3531	1.806e-159	507.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,4738R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	MmgE/PrpD family	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD3_k127_2690895_6	887898.HMPREF0551_0801	1.308e-22	115.0	2B0SP@1|root,31T51@2|Bacteria,1RFNM@1224|Proteobacteria	1224|Proteobacteria	S	Signal peptide protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2690895_0	1144319.PMI16_04333	2.341e-231	719.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VHJZ@28216|Betaproteobacteria,472IE@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the citrate synthase family	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
HKD3_k127_2690895_3	1123487.KB892835_gene3383	1.729e-149	477.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria,2KWMW@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphoenolpyruvate phosphomutase	-	-	5.4.2.9	ko:K01841	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R00661	RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD3_k127_2690895_4	795666.MW7_1300	2.048e-113	375.0	COG2301@1|root,COG2301@2|Bacteria,1Q91U@1224|Proteobacteria,2VJJY@28216|Betaproteobacteria,1K146@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	citE	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_2690895_1	1286093.C266_18236	3.341e-178	563.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2VHC8@28216|Betaproteobacteria,1K1KT@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD3_k127_2690895_5	1286093.C266_18231	9.484e-109	361.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,1K0QB@119060|Burkholderiaceae	28216|Betaproteobacteria	K	GntR family	frlR	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD3_k127_2700397_1	204773.HEAR2433	5.67e-319	988.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,4735C@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
HKD3_k127_2700397_16	887898.HMPREF0551_1233	2.447e-42	160.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria,1K7VB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD3_k127_2700397_12	977880.RALTA_A1848	3.109e-92	316.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,1K0BF@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD3_k127_2700397_0	887898.HMPREF0551_1231	5.4e-323	1000.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,1JZU5@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_2700397_18	420662.Mpe_A0056	1.504e-36	145.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,2VSPC@28216|Betaproteobacteria,1KMDW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HKD3_k127_2700397_8	1038869.AXAN01000010_gene5127	1.254e-144	465.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VJ8W@28216|Betaproteobacteria,1K21Y@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	dmlR2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_2700397_6	1121035.AUCH01000002_gene1457	2.224e-179	571.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KUW9@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD3_k127_2700397_23	522306.CAP2UW1_2634	1.281e-07	64.0	COG5608@1|root,COG5608@2|Bacteria,1N6YX@1224|Proteobacteria,2WFZ1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SMART Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
HKD3_k127_2700397_7	983917.RGE_29190	8.926e-174	554.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VJD8@28216|Betaproteobacteria,1KJK5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	PFAM Aminotransferase class I and II	ybdL	-	2.6.1.88	ko:K14287	-	-	R08618	RC00006,RC00025	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_2700397_21	887898.HMPREF0551_1188	4.083e-20	102.0	COG1569@1|root,COG1569@2|Bacteria,1NASM@1224|Proteobacteria,2VVUB@28216|Betaproteobacteria,1K7NV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HKD3_k127_2700397_20	339670.Bamb_2902	7.033e-22	103.0	COG1622@1|root,COG2010@1|root,COG2885@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,COG2885@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1K2B7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
HKD3_k127_2700397_10	287.DR97_4962	1.887e-109	365.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1YEHE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD3_k127_2700397_9	667632.KB890198_gene1221	8.111e-118	389.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2VKE7@28216|Betaproteobacteria,1K0D1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD3_k127_2700397_22	1000565.METUNv1_01928	6.78e-13	70.0	2EPEP@1|root,33H1B@2|Bacteria,1NHDJ@1224|Proteobacteria,2VXNY@28216|Betaproteobacteria,2KZUH@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3460
HKD3_k127_2700397_17	626418.bglu_1g10040	1.115e-36	151.0	COG2913@1|root,COG2913@2|Bacteria,1RBY9@1224|Proteobacteria,2VSW7@28216|Betaproteobacteria,1K4ZB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	(Lipo)protein	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
HKD3_k127_2700397_3	887898.HMPREF0551_1180	1.306e-213	677.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria,1K2AT@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfate permease family	sulP	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD3_k127_2700397_2	1265502.KB905933_gene2029	1.116e-304	972.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,4A9M6@80864|Comamonadaceae	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD3_k127_2700397_5	795666.MW7_2460	4.106e-186	587.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,1K0I7@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD3_k127_2700397_15	1123072.AUDH01000007_gene1207	4.355e-54	206.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,2JRR1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG0725 ABC-type molybdate transport system, periplasmic component	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD3_k127_2700397_14	296591.Bpro_0162	7.194e-87	292.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,4ABWJ@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD3_k127_2700397_13	296591.Bpro_0163	5.615e-92	334.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2WGQX@28216|Betaproteobacteria,4ADPZ@80864|Comamonadaceae	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.29,3.6.3.30,3.6.3.31	ko:K02010,ko:K02017,ko:K11072	ko02010,map02010	M00189,M00190,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11.1,3.A.1.8	-	-	ABC_tran,TOBE_2
HKD3_k127_2700397_4	381666.H16_B2109	3.154e-191	620.0	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,1KCSN@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TonB dependent receptor	yncD	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD3_k127_2700397_11	414684.RC1_3740	1.686e-95	333.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,2JQV1@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD3_k127_2700397_19	460265.Mnod_2736	2.656e-26	112.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2TV55@28211|Alphaproteobacteria,1JSIV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	HP	PFAM ABC transporter related	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD3_k127_2704654_13	1366050.N234_24945	2.469e-107	358.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1K1P2@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD3_k127_2704654_7	1157708.KB907453_gene4155	1.107e-137	456.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2VM19@28216|Betaproteobacteria,4ABT0@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HKD3_k127_2704654_20	640081.Dsui_0788	1.173e-65	231.0	COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,2VR4U@28216|Betaproteobacteria,2KWE8@206389|Rhodocyclales	206389|Rhodocyclales	H	2-phosphosulpholactate phosphatase	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
HKD3_k127_2704654_10	1157708.KB907477_gene1061	2.911e-123	428.0	COG4585@1|root,COG4585@2|Bacteria,1QUYA@1224|Proteobacteria,2WHKF@28216|Betaproteobacteria,4AJZ5@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HKD3_k127_2704654_17	864051.BurJ1DRAFT_3473	5.73e-71	246.0	COG2197@1|root,COG2197@2|Bacteria,1R2TM@1224|Proteobacteria,2W90D@28216|Betaproteobacteria,1KNTF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_2704654_0	258594.RPA4823	2.019e-271	847.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TT3K@28211|Alphaproteobacteria,3JV64@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_22915	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD3_k127_2704654_4	399795.CtesDRAFT_PD5488	6.941e-176	565.0	COG0183@1|root,COG0183@2|Bacteria,1MVPC@1224|Proteobacteria,2W2II@28216|Betaproteobacteria,4AHXN@80864|Comamonadaceae	28216|Betaproteobacteria	H	COG0183 Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2704654_19	1095769.CAHF01000021_gene943	2.23e-66	241.0	COG2755@1|root,COG2755@2|Bacteria,1MWT8@1224|Proteobacteria,2VVC1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Domain of Unknown Function (DUF1080)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080
HKD3_k127_2704654_14	203124.Tery_2914	9.137e-78	268.0	COG1028@1|root,COG1028@2|Bacteria,1G2ZD@1117|Cyanobacteria,1HAY2@1150|Oscillatoriales	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD3_k127_2704654_25	765912.Thimo_0453	3.942e-49	195.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales	135613|Chromatiales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD3_k127_2704654_9	397278.JOJN01000001_gene2775	3.556e-129	427.0	COG0477@1|root,COG2814@2|Bacteria,2I5XK@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_2704654_5	1157708.KB907451_gene4803	1.952e-143	471.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2VP3I@28216|Betaproteobacteria,4AE4X@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD3_k127_2704654_2	864051.BurJ1DRAFT_2978	3.026e-231	726.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1KJIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_2704654_23	640081.Dsui_2899	9.008e-56	215.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,2KVQX@206389|Rhodocyclales	206389|Rhodocyclales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_2704654_24	1031711.RSPO_c02410	4.836e-51	205.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,1K1KK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD3_k127_2704654_6	1095769.CAHF01000010_gene1130	6.816e-143	456.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,473RC@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD3_k127_2704654_22	614083.AWQR01000022_gene71	1.11e-58	211.0	COG1309@1|root,COG1309@2|Bacteria,1P4J2@1224|Proteobacteria,2VHWF@28216|Betaproteobacteria,4ABFR@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_2704654_18	497321.C664_02040	1.425e-66	229.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,2KWEI@206389|Rhodocyclales	206389|Rhodocyclales	U	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD3_k127_2704654_27	887898.HMPREF0551_1159	2.097e-42	168.0	COG2165@1|root,COG2165@2|Bacteria,1N8AD@1224|Proteobacteria,2VWBA@28216|Betaproteobacteria,1K7EA@119060|Burkholderiaceae	28216|Betaproteobacteria	U	general secretion pathway protein	gspH	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
HKD3_k127_2704654_29	760117.JN27_21555	9.436e-30	128.0	COG2165@1|root,COG2165@2|Bacteria,1N0C2@1224|Proteobacteria,2VVJ8@28216|Betaproteobacteria,474GX@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type II secretion system (T2SS), protein I	gspI	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSI
HKD3_k127_2704654_28	887898.HMPREF0551_1157	4.238e-34	144.0	COG4795@1|root,COG4795@2|Bacteria,1NIRI@1224|Proteobacteria,2VWRV@28216|Betaproteobacteria	28216|Betaproteobacteria	U	general secretion pathway protein	gspJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
HKD3_k127_2704654_26	795666.MW7_2223	7.877e-49	195.0	COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,2VS9P@28216|Betaproteobacteria,1K1E0@119060|Burkholderiaceae	28216|Betaproteobacteria	U	general secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HKD3_k127_2704654_15	887898.HMPREF0551_1155	1.247e-75	280.0	COG3297@1|root,COG3297@2|Bacteria,1N6IJ@1224|Proteobacteria,2VTP1@28216|Betaproteobacteria,1JZS7@119060|Burkholderiaceae	28216|Betaproteobacteria	U	General secretion pathway protein L	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
HKD3_k127_2704654_30	887898.HMPREF0551_1154	4.73e-28	129.0	COG3149@1|root,COG3149@2|Bacteria,1NAXX@1224|Proteobacteria,2VY4T@28216|Betaproteobacteria,1K14Z@119060|Burkholderiaceae	28216|Betaproteobacteria	U	General secretion pathway	gspM	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
HKD3_k127_2704654_21	887898.HMPREF0551_1153	1.484e-65	234.0	28IWK@1|root,2Z8UV@2|Bacteria,1P9EC@1224|Proteobacteria,2VJZY@28216|Betaproteobacteria,1KGQC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	General Secretory Pathway	gspN	-	-	ko:K02463	ko05111,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSN
HKD3_k127_2704654_3	887898.HMPREF0551_1152	2.127e-222	721.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,1K1ZV@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	general secretion pathway protein D	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD3_k127_2704654_1	887898.HMPREF0551_1151	9.693e-251	782.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1K2FT@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD3_k127_2704654_8	887898.HMPREF0551_1150	2.26e-137	449.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,1K2H7@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	General secretion pathway protein F	gspF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
HKD3_k127_2704654_32	887898.HMPREF0551_1147	1.048e-15	83.0	COG3339@1|root,COG3339@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD3_k127_2704654_12	1173021.ALWA01000035_gene3839	1.723e-108	366.0	COG0667@1|root,COG0667@2|Bacteria,1G2Y9@1117|Cyanobacteria	1117|Cyanobacteria	C	aldo keto reductase	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HKD3_k127_2704654_11	1095769.CAHF01000010_gene1134	2.917e-113	388.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,472WW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HKD3_k127_2704654_16	667632.KB890164_gene1891	8.519e-73	252.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1K2BP@119060|Burkholderiaceae	28216|Betaproteobacteria	MV	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_2734826_1	887898.HMPREF0551_1700	2.547e-130	420.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1K14Y@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_2734826_6	887898.HMPREF0551_1702	1.408e-48	188.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,2VRKW@28216|Betaproteobacteria,1K0RP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2734826_7	375286.mma_2969	1.719e-39	168.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,478RY@75682|Oxalobacteraceae	28216|Betaproteobacteria	CO	Thioredoxin-like	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD3_k127_2734826_4	1000565.METUNv1_02083	9.674e-61	214.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,2KWH7@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD3_k127_2734826_5	1123504.JQKD01000033_gene5242	1.618e-54	201.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,4AE38@80864|Comamonadaceae	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD3_k127_2734826_0	1095769.CAHF01000014_gene2868	2.737e-255	791.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,472TI@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD3_k127_2734826_3	1366050.N234_18020	3.684e-81	297.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,1K3BV@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD3_k127_2734826_8	887898.HMPREF0551_1708	1.421e-35	153.0	2A4J7@1|root,32X19@2|Bacteria,1N1MY@1224|Proteobacteria,2WGFQ@28216|Betaproteobacteria,1KIDN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4,zinc_ribbon_5
HKD3_k127_2734826_2	887898.HMPREF0551_1709	3.203e-122	404.0	COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,1K1IG@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM PfkB domain protein	adoK	-	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD3_k127_2734826_9	1120999.JONM01000023_gene3164	5.152e-14	77.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,2KRZB@206351|Neisseriales	206351|Neisseriales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD3_k127_2734826_10	977880.RALTA_B0180	7.507e-14	72.0	COG0762@1|root,COG0762@2|Bacteria,1RGN1@1224|Proteobacteria,2VT0E@28216|Betaproteobacteria,1K06T@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD3_k127_2745895_9	522306.CAP2UW1_2301	8.936e-56	196.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1KQQP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD3_k127_2745895_5	1157708.KB907461_gene1537	1.124e-68	247.0	COG0596@1|root,COG0596@2|Bacteria,1R3U1@1224|Proteobacteria,2VNZR@28216|Betaproteobacteria,4A9XT@80864|Comamonadaceae	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD3_k127_2745895_8	1000565.METUNv1_00064	8.345e-57	205.0	28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,2VRVF@28216|Betaproteobacteria,2KYT9@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HKD3_k127_2745895_2	1392838.AWNM01000018_gene3493	6.232e-138	462.0	COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria,3T35K@506|Alcaligenaceae	28216|Betaproteobacteria	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HKD3_k127_2745895_10	266265.Bxe_C0036	4.211e-34	151.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VT4G@28216|Betaproteobacteria,1K4A3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD3_k127_2745895_7	667632.KB890171_gene3535	1.222e-58	224.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,1K32J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Smr protein MutS2	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD3_k127_2745895_1	395019.Bmul_2424	9.422e-163	516.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2VIVV@28216|Betaproteobacteria,1K2A5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_2745895_4	887898.HMPREF0551_1003	2.809e-95	339.0	COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,2VRYB@28216|Betaproteobacteria,1K34H@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_2745895_0	1218074.BAXZ01000010_gene2660	1.444e-303	949.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,1K2W2@119060|Burkholderiaceae	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD3_k127_2745895_6	1095769.CAHF01000011_gene2597	5.747e-66	232.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VQH0@28216|Betaproteobacteria,472W8@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD3_k127_2745895_3	375286.mma_0025	1.504e-98	342.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2VIUU@28216|Betaproteobacteria,478NG@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HKD3_k127_2756524_12	1265502.KB905931_gene1642	8.48e-38	164.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VJ74@28216|Betaproteobacteria,4AB8F@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K07552,ko:K18552	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.2,2.A.1.2.3	-	-	MFS_1
HKD3_k127_2756524_2	267608.RSc2563	1.56e-195	627.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,1JZY0@119060|Burkholderiaceae	28216|Betaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD3_k127_2756524_7	887898.HMPREF0551_1546	9.447e-92	334.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,1K18A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pfam SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD3_k127_2756524_1	742823.HMPREF9465_00614	1.299e-245	795.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2VIV3@28216|Betaproteobacteria,4PQH6@995019|Sutterellaceae	28216|Betaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HKD3_k127_2756524_4	267608.RSc2539	2.28e-141	467.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,1K2TE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	N-Acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HKD3_k127_2756524_11	1123392.AQWL01000003_gene308	6.925e-39	154.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2VSJY@28216|Betaproteobacteria,1KRSW@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	-	-	-	-	-	-	-	-	-	TsaE
HKD3_k127_2756524_3	1095769.CAHF01000001_gene3436	2.148e-141	462.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,473I6@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD3_k127_2756524_15	1304883.KI912532_gene1804	7.855e-14	82.0	COG4309@1|root,COG4309@2|Bacteria,1NHRT@1224|Proteobacteria,2VXM5@28216|Betaproteobacteria,2KXKD@206389|Rhodocyclales	206389|Rhodocyclales	S	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD3_k127_2756524_10	1123368.AUIS01000008_gene2157	4.048e-68	239.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,2NCTJ@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Transcriptional regulator, Crp Fnr family	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_2756524_8	204773.HEAR1684	9.509e-85	287.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,4747S@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_2756524_14	1033802.SSPSH_002846	1.662e-31	128.0	COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,1S70H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Invasion gene expression up-regulator SirB	-	-	-	-	-	-	-	-	-	-	-	-	SirB
HKD3_k127_2756524_16	1121035.AUCH01000016_gene2125	5.647e-10	74.0	COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,2KU6N@206389|Rhodocyclales	206389|Rhodocyclales	C	cytochrome	nirN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HKD3_k127_2756524_13	243365.CV_0175	2.813e-33	131.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KRVU@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_2756524_0	1121035.AUCH01000016_gene2118	7.67e-309	954.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,2KVT2@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome D1 heme domain	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HKD3_k127_2756524_6	580332.Slit_1130	2.06e-108	379.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2W973@28216|Betaproteobacteria,44WC7@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD3_k127_2756524_9	1532557.JL37_05070	1.677e-81	281.0	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2VIM5@28216|Betaproteobacteria,3T1J8@506|Alcaligenaceae	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD3_k127_2756524_5	1229205.BUPH_03390	4.062e-123	401.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,1K1BK@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD3_k127_297488_2	864073.HFRIS_022983	3.141e-236	738.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,472PS@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
HKD3_k127_297488_4	1144319.PMI16_02918	1.673e-177	569.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VH8F@28216|Betaproteobacteria,472CF@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Transcriptional regulator with HTH domain and aminotransferase domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HKD3_k127_297488_11	977880.RALTA_A2150	4.123e-40	156.0	COG1280@1|root,COG1280@2|Bacteria,1R551@1224|Proteobacteria,2VQGF@28216|Betaproteobacteria	28216|Betaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD3_k127_297488_9	381666.H16_A2659	2.088e-77	290.0	COG0697@1|root,COG0697@2|Bacteria,1MVHN@1224|Proteobacteria,2VI21@28216|Betaproteobacteria,1KH5K@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_297488_10	1502851.FG93_03267	7.756e-74	272.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,3JTH6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD3_k127_297488_8	1175306.GWL_12510	7.425e-121	397.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,4742I@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_297488_7	1144319.PMI16_04847	3.079e-146	484.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria,477GY@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_297488_5	864051.BurJ1DRAFT_0686	5.934e-159	509.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria,1KKBG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HKD3_k127_297488_3	1095769.CAHF01000007_gene1661	1.319e-207	654.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VJYY@28216|Betaproteobacteria	28216|Betaproteobacteria	G	ABC-type sugar transport system, periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD3_k127_297488_6	1120792.JAFV01000001_gene3423	6.113e-152	488.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,36ZTJ@31993|Methylocystaceae	28211|Alphaproteobacteria	E	TOBE domain	MA20_27205	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD3_k127_297488_1	859657.RPSI07_2421	0.0	1019.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,1K1BN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD3_k127_297488_0	1095769.CAHF01000013_gene3169	0.0	1095.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,472AH@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD3_k127_297488_12	640081.Dsui_2911	6.341e-34	134.0	COG2076@1|root,COG2076@2|Bacteria,1RHUW@1224|Proteobacteria,2VSEI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Small multidrug resistance	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
HKD3_k127_297488_13	1040989.AWZU01000004_gene6944	4.309e-26	113.0	COG0515@1|root,COG0589@1|root,COG0515@2|Bacteria,COG0589@2|Bacteria,1MV1P@1224|Proteobacteria,2TQTS@28211|Alphaproteobacteria,3JSWF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KLT	Serine threonine protein kinase	MA20_09295	-	-	-	-	-	-	-	-	-	-	-	Pkinase,Usp
HKD3_k127_3054606_0	1265502.KB905934_gene3276	3.616e-280	879.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,4AAZM@80864|Comamonadaceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA2	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD3_k127_3054606_12	713587.THITH_03965	1.042e-11	78.0	COG1416@1|root,COG1416@2|Bacteria,1N64N@1224|Proteobacteria,1SNQX@1236|Gammaproteobacteria,1X1RU@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD3_k127_3054606_4	1382303.JPOM01000001_gene1015	2.08e-159	511.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,2KFBC@204458|Caulobacterales	204458|Caulobacterales	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD3_k127_3054606_5	358220.C380_19495	4.846e-110	364.0	COG0753@1|root,COG0753@2|Bacteria,1N4WM@1224|Proteobacteria,2VV71@28216|Betaproteobacteria,4AI8G@80864|Comamonadaceae	28216|Betaproteobacteria	P	Catalase	-	-	-	-	-	-	-	-	-	-	-	-	Catalase
HKD3_k127_3054606_10	338969.Rfer_0574	7.16e-50	183.0	COG1764@1|root,COG1764@2|Bacteria,1RD1A@1224|Proteobacteria,2VR4T@28216|Betaproteobacteria,4ADK9@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_3054606_11	381666.H16_B0158	2.609e-46	183.0	COG1846@1|root,COG1846@2|Bacteria,1RH1F@1224|Proteobacteria,2VRNB@28216|Betaproteobacteria,1K3PU@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	ohrR	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD3_k127_3054606_8	1112217.PPL19_18967	9.814e-62	226.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD3_k127_3054606_7	342113.DM82_4886	1.338e-101	343.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,2WASJ@28216|Betaproteobacteria,1K40Q@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Helix-hairpin-helix domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_5,HHH_8
HKD3_k127_3054606_3	322710.Avin_46230	7.737e-167	550.0	COG1488@1|root,COG1488@2|Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
HKD3_k127_3054606_2	305700.B447_17094	1.808e-239	751.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,2KUH8@206389|Rhodocyclales	206389|Rhodocyclales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD3_k127_3054606_1	420662.Mpe_A1097	1.057e-248	801.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1KJIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_3054606_6	1121127.JAFA01000003_gene1888	2.01e-104	351.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,2VIJP@28216|Betaproteobacteria,1K2P4@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the peptidase M20A family. ArgE subfamily	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_3054606_9	1123368.AUIS01000028_gene1327	5.372e-59	225.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3060166_1	983917.RGE_21180	1.569e-238	744.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VJK5@28216|Betaproteobacteria,1KMXM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD3_k127_3060166_5	404589.Anae109_3145	1.174e-111	372.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	Hemerythrin,PAS_10
HKD3_k127_3060166_7	883126.HMPREF9710_01604	1.039e-83	307.0	2C2MV@1|root,32RAQ@2|Bacteria,1QXW5@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD3_k127_3060166_3	883126.HMPREF9710_01605	8.62e-161	530.0	COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2VHMP@28216|Betaproteobacteria,474HB@75682|Oxalobacteraceae	28216|Betaproteobacteria	GM	ABC-type polysaccharide polyol phosphate transport system, ATPase component	wzt	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HKD3_k127_3060166_6	883126.HMPREF9710_01606	3.912e-108	357.0	COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,2VHT7@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	Transport permease protein	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HKD3_k127_3060166_0	1216007.AOPM01000052_gene2121	2.537e-292	921.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,2Q004@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD3_k127_3060166_4	204773.HEAR0003	2.907e-154	494.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,47303@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD3_k127_3060166_2	29581.BW37_03607	7.836e-174	557.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,47248@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD3_k127_3060166_8	640081.Dsui_0833	6.837e-13	82.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,2VXTS@28216|Betaproteobacteria,2KXH4@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD3_k127_3096729_10	887898.HMPREF0551_0775	1.078e-73	265.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,1K319@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyhydroxyalkanoate synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD3_k127_3096729_4	887898.HMPREF0551_0776	1.358e-124	403.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,1K2WG@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	phbB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HKD3_k127_3096729_0	1031711.RSPO_c01711	1.503e-210	671.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,1K2H0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Poly(R)-hydroxyalkanoic acid synthase, class I	phbC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PhaC_N
HKD3_k127_3096729_13	1144319.PMI16_00710	6.253e-11	67.0	2E3TT@1|root,32YR7@2|Bacteria,1N9R9@1224|Proteobacteria,2VW0P@28216|Betaproteobacteria,47540@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3096729_9	1217718.ALOU01000041_gene33	1.329e-76	270.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,1K3K8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD3_k127_3096729_7	887898.HMPREF0551_0780	6.307e-98	332.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2VIFF@28216|Betaproteobacteria,1JZYN@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD3_k127_3096729_8	402626.Rpic_1920	1.202e-84	309.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1K217@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD3_k127_3096729_1	264198.Reut_A1342	1.901e-186	617.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2VH0V@28216|Betaproteobacteria,1K1T6@119060|Burkholderiaceae	28216|Betaproteobacteria	KL	helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD3_k127_3096729_12	1500894.JQNN01000001_gene2224	1.77e-18	89.0	COG5481@1|root,COG5481@2|Bacteria,1R3J0@1224|Proteobacteria,2WIIA@28216|Betaproteobacteria,4751S@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HKD3_k127_3096729_11	305700.B447_20623	8.59e-41	162.0	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,2VK9S@28216|Betaproteobacteria,2KVCJ@206389|Rhodocyclales	206389|Rhodocyclales	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
HKD3_k127_3096729_6	305700.B447_00070	1.079e-99	360.0	COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,2VK1M@28216|Betaproteobacteria,2KUAQ@206389|Rhodocyclales	206389|Rhodocyclales	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
HKD3_k127_3096729_5	420662.Mpe_A3511	2.539e-109	370.0	COG0714@1|root,COG0714@2|Bacteria,1PM35@1224|Proteobacteria,2VM64@28216|Betaproteobacteria,1KK0U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
HKD3_k127_3096729_2	859657.RPSI07_2093	2.025e-161	531.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,1K0KZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM AFG1-family ATPase	yhcM	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HKD3_k127_3096729_3	1562701.BBOF01000022_gene698	1.11e-155	495.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1K1N0@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Dehydrogenase	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD3_k127_3192280_2	305700.B447_07457	3.309e-143	456.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,2KUS3@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_3192280_4	1439940.BAY1663_03521	5.908e-85	297.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HKD3_k127_3192280_3	1485544.JQKP01000001_gene1330	2.583e-90	315.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2VI50@28216|Betaproteobacteria,44VGA@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD3_k127_3192280_5	1538295.JY96_03985	3.699e-28	122.0	COG1495@1|root,COG1495@2|Bacteria,1N0J6@1224|Proteobacteria,2VTZK@28216|Betaproteobacteria,1KMCI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	bond formation protein DsbB	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HKD3_k127_3192280_1	1366050.N234_19975	7.23e-156	505.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VK35@28216|Betaproteobacteria,1K4WY@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Sulfide dehydrogenase	soxF	-	1.8.2.1,1.8.5.4	ko:K05301,ko:K17218	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00528,R10152	RC00168,RC03155	ko00000,ko00001,ko01000	-	-	-	FCSD-flav_bind,Pyr_redox_2,TAT_signal
HKD3_k127_3192280_6	420662.Mpe_A1476	4.272e-16	93.0	COG2863@1|root,COG2863@2|Bacteria,1NGJ1@1224|Proteobacteria,2VVR2@28216|Betaproteobacteria,1KMR7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_3192280_0	1005048.CFU_3265	0.0	1267.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,472J7@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD3_k127_3230304_0	93220.LV28_04490	9.089e-229	713.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1K1VP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	o-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_3230304_1	1095769.CAHF01000011_gene2561	1.457e-87	322.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2VJQ3@28216|Betaproteobacteria,472AB@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,FSH1
HKD3_k127_3230304_2	1223521.BBJX01000018_gene651	1.043e-23	109.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,4AA9B@80864|Comamonadaceae	28216|Betaproteobacteria	S	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD3_k127_3246665_15	1265502.KB905940_gene3000	6.682e-98	322.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VINK@28216|Betaproteobacteria,4A9WA@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_3246665_3	543728.Vapar_0329	1.457e-202	655.0	COG3386@1|root,COG3391@1|root,COG3386@2|Bacteria,COG3391@2|Bacteria,1PXBC@1224|Proteobacteria,2VVHP@28216|Betaproteobacteria,4AGKM@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3246665_1	1095769.CAHF01000011_gene2104	7e-323	1029.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,472N4@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD3_k127_3246665_4	1095769.CAHF01000011_gene2194	1.176e-197	621.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,476XW@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_3246665_10	1122604.JONR01000004_gene881	6.629e-115	395.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RP4C@1236|Gammaproteobacteria,1X3HD@135614|Xanthomonadales	135614|Xanthomonadales	S	Alpha beta hydrolase	dhaA	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
HKD3_k127_3246665_12	264198.Reut_A1409	1.199e-109	362.0	COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2VH22@28216|Betaproteobacteria,1K4AS@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate	gno1	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short,adh_short_C2
HKD3_k127_3246665_22	1218084.BBJK01000094_gene6111	1.295e-30	127.0	COG2050@1|root,COG2050@2|Bacteria,1MYG1@1224|Proteobacteria,2VTQD@28216|Betaproteobacteria,1K6EA@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD3_k127_3246665_7	640511.BC1002_1479	6.175e-150	488.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VIE7@28216|Betaproteobacteria,1K1B6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HKD3_k127_3246665_9	365046.Rta_19980	3.986e-116	383.0	COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2VSCY@28216|Betaproteobacteria,4AEWX@80864|Comamonadaceae	28216|Betaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD3_k127_3246665_14	1123504.JQKD01000027_gene4146	1.057e-104	362.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VJXG@28216|Betaproteobacteria,4AC6Z@80864|Comamonadaceae	28216|Betaproteobacteria	G	Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD3_k127_3246665_16	1458357.BG58_19475	5.585e-96	337.0	COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2WGHU@28216|Betaproteobacteria,1K427@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_3246665_13	402626.Rpic_1436	1.177e-106	370.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2VJ9I@28216|Betaproteobacteria,1K4P5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD3_k127_3246665_11	216591.BCAL1969	3.623e-113	373.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VJSB@28216|Betaproteobacteria,1K06E@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HKD3_k127_3246665_21	667632.KB890209_gene5307	1.6e-32	148.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,1K8P2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM GCN5-related N-acetyltransferase	yjcF	-	-	-	-	-	-	-	-	-	-	-	4HBT,Acetyltransf_10
HKD3_k127_3246665_19	1157708.KB907451_gene4742	9.839e-59	233.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VNMX@28216|Betaproteobacteria,4AAMC@80864|Comamonadaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	pldB	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
HKD3_k127_3246665_23	378806.STAUR_6252	5.915e-15	77.0	COG4770@1|root,COG4770@2|Bacteria,1NJ80@1224|Proteobacteria,42WV4@68525|delta/epsilon subdivisions,2WT3X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acetyl propionyl-CoA carboxylase alpha subunit	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD3_k127_3246665_18	1424334.W822_10105	4.617e-60	218.0	COG1802@1|root,COG1802@2|Bacteria,1NEIS@1224|Proteobacteria,2W18M@28216|Betaproteobacteria,3T79F@506|Alcaligenaceae	28216|Betaproteobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD3_k127_3246665_5	1424334.W822_10120	3.535e-169	553.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2WDX5@28216|Betaproteobacteria,3T5N4@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD3_k127_3246665_20	399795.CtesDRAFT_PD5389	1.009e-55	213.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,4AJ0K@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD3_k127_3246665_2	1424334.W822_10125	1.492e-222	719.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VZED@28216|Betaproteobacteria,3T8VQ@506|Alcaligenaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD3_k127_3246665_8	1366050.N234_18985	6.316e-125	414.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23,OmpA
HKD3_k127_3246665_0	977880.RALTA_A2813	0.0	1259.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_3246665_6	335543.Sfum_1077	2.622e-157	512.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HKD3_k127_3246665_17	631362.Thi970DRAFT_00381	3.335e-66	244.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RRXM@1236|Gammaproteobacteria,1WYGD@135613|Chromatiales	135613|Chromatiales	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_3246665_24	1041142.ATTP01000003_gene3323	6.136e-06	60.0	2DQB4@1|root,335RD@2|Bacteria,1NEDH@1224|Proteobacteria,2V6NQ@28211|Alphaproteobacteria,4BCBJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD3_k127_3323909_3	1231391.AMZF01000022_gene1229	6.948e-124	406.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VN4I@28216|Betaproteobacteria,3T6WQ@506|Alcaligenaceae	28216|Betaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD3_k127_3323909_5	1211115.ALIQ01000047_gene3031	1.027e-97	326.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Methyltransferase	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
HKD3_k127_3323909_11	1265313.HRUBRA_02233	9.105e-61	226.0	COG3015@1|root,COG3126@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3126@2|Bacteria,COG3187@2|Bacteria,1Q2E0@1224|Proteobacteria,1TAK6@1236|Gammaproteobacteria,1J7D8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	MOP	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META,NlpE,YscW
HKD3_k127_3323909_6	991905.SL003B_2483	2.698e-95	316.0	28N0F@1|root,2ZB6V@2|Bacteria,1R4J3@1224|Proteobacteria,2VCSJ@28211|Alphaproteobacteria,4BSIC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HKD3_k127_3323909_1	1500894.JQNN01000001_gene1037	7.46e-205	662.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VHMA@28216|Betaproteobacteria,47254@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	aidB	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD3_k127_3323909_12	292415.Tbd_2162	8.725e-53	194.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.265	ko:K16868	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
HKD3_k127_3323909_10	1205680.CAKO01000038_gene1961	1.806e-69	268.0	COG1024@1|root,COG1024@2|Bacteria,1RG4N@1224|Proteobacteria,2U8TJ@28211|Alphaproteobacteria,2JWTN@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_3323909_8	1123393.KB891330_gene853	7.633e-82	286.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VH5N@28216|Betaproteobacteria,1KSQF@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD3_k127_3323909_7	292415.Tbd_0248	8.109e-92	310.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJK6@28216|Betaproteobacteria,1KRJG@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_3323909_14	292415.Tbd_0250	5.523e-24	117.0	COG3218@1|root,COG3218@2|Bacteria	2|Bacteria	Q	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HKD3_k127_3323909_0	266264.Rmet_3551	1.189e-234	734.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1K17A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD3_k127_3323909_13	1366050.N234_20785	5.533e-32	132.0	2C1K4@1|root,30F52@2|Bacteria,1REDQ@1224|Proteobacteria,2VRSY@28216|Betaproteobacteria,1KCUQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD3_k127_3323909_2	264198.Reut_A3429	3.461e-140	464.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VJTU@28216|Betaproteobacteria,1K5K4@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD3_k127_3323909_9	1217718.ALOU01000058_gene676	7.128e-72	259.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,1JZZC@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycolate phosphatase	gph	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD3_k127_3323909_4	1217718.ALOU01000058_gene677	1.879e-101	337.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2VHGP@28216|Betaproteobacteria,1K206@119060|Burkholderiaceae	28216|Betaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
HKD3_k127_3323909_15	296591.Bpro_1796	1.923e-11	64.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,4ACAI@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	ompA	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HKD3_k127_3380539_4	663610.JQKO01000011_gene3320	2.425e-175	557.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,3NASQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD3_k127_3380539_14	1276756.AUEX01000031_gene167	5.169e-66	237.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,4ADS8@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_3380539_13	1157708.KB907457_gene2545	1.736e-78	271.0	COG2249@1|root,COG2249@2|Bacteria,1MXFT@1224|Proteobacteria,2VMX3@28216|Betaproteobacteria,4ACHG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavodoxin-like fold	kefF	-	1.6.5.2	ko:K00355,ko:K11746,ko:K11748	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000,ko02000	2.A.37.1.1,2.A.37.1.2	-	-	Flavodoxin_2
HKD3_k127_3380539_0	614083.AWQR01000029_gene2136	9.532e-272	847.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,4AABC@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefC	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HKD3_k127_3380539_1	76114.ebA4224	3.015e-244	769.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2VH8W@28216|Betaproteobacteria,2KUTU@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA helicase	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
HKD3_k127_3380539_17	399795.CtesDRAFT_PD3198	1.002e-14	84.0	COG0589@1|root,COG0589@2|Bacteria,1N674@1224|Proteobacteria,2VXIR@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_3380539_12	977880.RALTA_A1795	1.582e-80	279.0	COG2030@1|root,COG2030@2|Bacteria,1N20D@1224|Proteobacteria	1224|Proteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD3_k127_3380539_10	267608.RSp0711	2.337e-89	307.0	COG5486@1|root,COG5486@2|Bacteria,1R6FN@1224|Proteobacteria,2VMCU@28216|Betaproteobacteria,1K22S@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
HKD3_k127_3380539_11	196367.JNFG01000065_gene940	4.21e-87	292.0	COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2VMAI@28216|Betaproteobacteria,1JZMB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HKD3_k127_3380539_2	381666.H16_A2252	7.949e-222	704.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2W0KE@28216|Betaproteobacteria,1KC14@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_3380539_15	1128421.JAGA01000001_gene2263	1.018e-51	206.0	COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_3380539_6	543728.Vapar_2422	5.223e-153	509.0	COG4177@1|root,COG4177@2|Bacteria,1MZDJ@1224|Proteobacteria,2VJSE@28216|Betaproteobacteria,4AAFD@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_3380539_5	398578.Daci_2554	5.531e-155	510.0	COG0559@1|root,COG0559@2|Bacteria,1MVZ5@1224|Proteobacteria,2VJCG@28216|Betaproteobacteria,4AC0G@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_3380539_9	1121920.AUAU01000008_gene1545	9.399e-112	380.0	COG0410@1|root,COG0410@2|Bacteria,3Y9ED@57723|Acidobacteria	2|Bacteria	E	ABC transporter	livF_1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_3380539_8	1121920.AUAU01000008_gene1546	1.137e-119	390.0	COG0411@1|root,COG0411@2|Bacteria	2|Bacteria	E	ABC transporter	MA20_23480	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_3380539_3	1265502.KB905938_gene2425	1.74e-196	628.0	COG0683@1|root,COG0683@2|Bacteria,1N1MX@1224|Proteobacteria,2VJMT@28216|Betaproteobacteria,4AC97@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_3380539_7	748247.AZKH_2018	2.897e-149	489.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQ9@28216|Betaproteobacteria,2KXZ0@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD3_k127_3380539_16	76114.ebA5107	5.418e-28	118.0	COG4967@1|root,COG4967@2|Bacteria,1RKWI@1224|Proteobacteria,2VT6F@28216|Betaproteobacteria,2KXQA@206389|Rhodocyclales	206389|Rhodocyclales	NU	type IV pilus modification protein PilV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3582049_1	1095769.CAHF01000011_gene2595	3.208e-189	597.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,473JN@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD3_k127_3582049_0	1003200.AXXA_16267	1.378e-207	656.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2VHN9@28216|Betaproteobacteria,3T1J9@506|Alcaligenaceae	28216|Betaproteobacteria	L	Recombination factor protein RarA	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD3_k127_3582049_2	864051.BurJ1DRAFT_2514	6.947e-117	390.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2VHHN@28216|Betaproteobacteria,1KK4R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_3582049_3	375286.mma_0025	1.891e-32	127.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2VIUU@28216|Betaproteobacteria,478NG@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HKD3_k127_3634226_15	640081.Dsui_3186	1.171e-100	342.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KUPY@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
HKD3_k127_3634226_23	887898.HMPREF0551_1090	1.262e-16	90.0	COG1286@1|root,COG1286@2|Bacteria	2|Bacteria	S	toxin biosynthetic process	cvpA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD3_k127_3634226_22	1005048.CFU_1877	4.619e-33	139.0	COG3147@1|root,COG3147@2|Bacteria,1R7IV@1224|Proteobacteria,2VPE1@28216|Betaproteobacteria,4743J@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Sporulation related domain	dedD	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
HKD3_k127_3634226_8	1003200.AXXA_22530	5.867e-171	561.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD3_k127_3634226_12	626418.bglu_2g08450	2.216e-147	473.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,1K1C4@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD3_k127_3634226_16	626418.bglu_2g08440	2.106e-94	334.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,1K2CE@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD3_k127_3634226_2	159450.NH14_21930	1.263e-226	710.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,1JZSI@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_3634226_21	1121035.AUCH01000014_gene2424	4.287e-62	224.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria,2KU7Q@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD3_k127_3634226_18	568706.BN118_1142	2.345e-83	299.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria,3T26B@506|Alcaligenaceae	28216|Betaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD3_k127_3634226_10	375286.mma_2167	2.55e-154	523.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,473WU@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	LysM domain	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
HKD3_k127_3634226_6	948106.AWZT01000049_gene495	2.094e-177	563.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,1K10F@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD3_k127_3634226_7	887898.HMPREF0551_1100	1.03e-172	547.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,1K05E@119060|Burkholderiaceae	28216|Betaproteobacteria	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD3_k127_3634226_14	1095769.CAHF01000011_gene2553	2.018e-108	360.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,472UP@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD3_k127_3634226_1	987059.RBXJA2T_03416	9.326e-243	759.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,1KIWD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD3_k127_3634226_20	887898.HMPREF0551_1104	7.347e-69	259.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,1JZNN@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD3_k127_3634226_17	1095769.CAHF01000011_gene2556	7.399e-88	306.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria,475SR@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Nucleoside H+ symporter	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
HKD3_k127_3634226_5	1095769.CAHF01000011_gene2557	1.921e-186	591.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,472QI@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD3_k127_3634226_11	1286631.X805_29370	2.72e-151	485.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,1KKBI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_3634226_3	1123392.AQWL01000008_gene1243	1.643e-212	669.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2VH5S@28216|Betaproteobacteria,1KSPK@119069|Hydrogenophilales	119069|Hydrogenophilales	J	tRNA synthetases class I (E and Q), catalytic domain	-	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD3_k127_3634226_13	368407.Memar_1510	1.603e-133	439.0	COG2133@1|root,arCOG02796@2157|Archaea	2157|Archaea	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD3_k127_3634226_4	395019.Bmul_5971	2.181e-203	666.0	COG4772@1|root,COG4772@2|Bacteria,1MXJU@1224|Proteobacteria,2VN9X@28216|Betaproteobacteria,1K2NQ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD3_k127_3634226_19	365044.Pnap_3008	1.544e-72	250.0	COG2863@1|root,COG2863@2|Bacteria,1PFFQ@1224|Proteobacteria,2VXBF@28216|Betaproteobacteria,4AFPX@80864|Comamonadaceae	28216|Betaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_3634226_0	365044.Pnap_3007	3.634e-306	945.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VMVP@28216|Betaproteobacteria,4AJ78@80864|Comamonadaceae	28216|Betaproteobacteria	G	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2,PQQ_3
HKD3_k127_3662085_21	795666.MW7_0208	5.659e-07	60.0	2EKB7@1|root,33E1K@2|Bacteria,1NJX9@1224|Proteobacteria,2VYAE@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3662085_20	1286631.X805_00440	4.211e-14	84.0	COG2606@1|root,COG3313@1|root,COG2606@2|Bacteria,COG3313@2|Bacteria,1RD82@1224|Proteobacteria,2VQJW@28216|Betaproteobacteria,1KKV3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	YbaK prolyl-tRNA synthetase associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1289,tRNA_edit
HKD3_k127_3662085_6	1095769.CAHF01000005_gene1504	2.255e-132	430.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2VIUW@28216|Betaproteobacteria,47334@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	HMGL-like	hmgcL	GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD3_k127_3662085_13	748280.NH8B_2960	3.105e-79	275.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VIH8@28216|Betaproteobacteria,2KSGD@206351|Neisseriales	206351|Neisseriales	C	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
HKD3_k127_3662085_2	1095769.CAHF01000005_gene1505	1.043e-271	853.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,472UQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acetyl propionyl-CoA carboxylase, alpha subunit	accA1	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD3_k127_3662085_17	760117.JN27_01745	2.486e-42	165.0	COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2VPEY@28216|Betaproteobacteria,474NJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	LysE type translocator	leuE_1	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD3_k127_3662085_12	1123504.JQKD01000002_gene3715	7.959e-84	307.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VI5G@28216|Betaproteobacteria,4AAYE@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.18	ko:K13766,ko:K15312	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	ECH_1
HKD3_k127_3662085_0	1095769.CAHF01000005_gene1511	1.09e-294	919.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,47381@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	accB	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD3_k127_3662085_14	438753.AZC_4590	6.423e-56	204.0	COG1309@1|root,COG1309@2|Bacteria,1R7JI@1224|Proteobacteria,2U0P5@28211|Alphaproteobacteria,3F1CP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	YsiA-like protein, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
HKD3_k127_3662085_9	1384056.N787_05715	2.284e-95	333.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,1RMZR@1236|Gammaproteobacteria,1X37N@135614|Xanthomonadales	135614|Xanthomonadales	F	deiminase	sdeB	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD3_k127_3662085_5	1502851.FG93_00408	6.622e-156	502.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,3JVJX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD3_k127_3662085_11	795666.MW7_2138	7.631e-90	321.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2VK2Y@28216|Betaproteobacteria,1JZPU@119060|Burkholderiaceae	28216|Betaproteobacteria	E	N-formylglutamate amidohydrolase	hutG	-	3.5.1.68,3.5.3.8	ko:K01458,ko:K01479	ko00340,ko00630,ko01100,map00340,map00630,map01100	M00045	R00525,R02285	RC00165,RC00221,RC00323,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
HKD3_k127_3662085_3	1122604.JONR01000025_gene4545	1.033e-189	607.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria,1X39J@135614|Xanthomonadales	135614|Xanthomonadales	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD3_k127_3662085_19	68199.JNZO01000008_gene7650	4.769e-19	94.0	COG3758@1|root,COG3758@2|Bacteria,2IFWP@201174|Actinobacteria	201174|Actinobacteria	S	HutD	ves	-	-	ko:K09975	-	-	-	-	ko00000	-	-	-	HutD
HKD3_k127_3662085_1	1500890.JQNL01000001_gene3003	1.427e-282	897.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,1RP89@1236|Gammaproteobacteria,1X3IN@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD3_k127_3662085_15	395019.Bmul_5005	1.302e-52	213.0	COG2188@1|root,COG2188@2|Bacteria,1MVFM@1224|Proteobacteria,2VP9K@28216|Betaproteobacteria,1K02N@119060|Burkholderiaceae	28216|Betaproteobacteria	K	histidine utilization repressor	hutC	-	-	ko:K05836	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD3_k127_3662085_4	1038859.AXAU01000024_gene4022	7.881e-159	507.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2TTB8@28211|Alphaproteobacteria,3JVA6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NMT1-like family	MA20_34190	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD3_k127_3662085_7	1411123.JQNH01000001_gene2360	3.534e-130	423.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TRDG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	MA20_34185	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_3662085_8	688245.CtCNB1_0162	4.994e-120	392.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VMYS@28216|Betaproteobacteria,4ACPW@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	cmpD_2	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_3662085_10	991905.SL003B_3243	1.967e-91	306.0	COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2TR9W@28211|Alphaproteobacteria,4BS57@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	MA20_04615	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD3_k127_3662085_16	686340.Metal_1382	8.685e-51	190.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,1S43M@1236|Gammaproteobacteria,1XGCZ@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
HKD3_k127_3662085_18	1265502.KB905932_gene1922	1.47e-30	121.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,4AB39@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_371084_13	1121935.AQXX01000137_gene3918	2.993e-12	67.0	COG4736@1|root,COG4736@2|Bacteria,1NGAN@1224|Proteobacteria,1SGJ2@1236|Gammaproteobacteria,1XMQT@135619|Oceanospirillales	135619|Oceanospirillales	O	Cbb3-type cytochrome oxidase component FixQ	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
HKD3_k127_371084_3	29581.BW37_02675	6.2e-122	398.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,4726F@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD3_k127_371084_0	338969.Rfer_1934	7.142e-206	652.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,4AB30@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD3_k127_371084_11	159087.Daro_0718	2.34e-30	130.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales	206389|Rhodocyclales	S	FixH family	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
HKD3_k127_371084_12	795666.MW7_3504	2.366e-14	77.0	2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,2VU0U@28216|Betaproteobacteria,1K9PW@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_371084_5	211165.AJLN01000100_gene4105	4.481e-101	336.0	COG1028@1|root,COG1028@2|Bacteria,1G4KK@1117|Cyanobacteria	1117|Cyanobacteria	IQ	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_371084_9	85643.Tmz1t_3911	1.278e-36	147.0	COG2062@1|root,COG2062@2|Bacteria,1RIC8@1224|Proteobacteria,2VUGF@28216|Betaproteobacteria,2M04K@206389|Rhodocyclales	206389|Rhodocyclales	T	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD3_k127_371084_4	404589.Anae109_0029	1.137e-104	364.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HKD3_k127_371084_10	1100721.ALKO01000021_gene734	1.832e-34	136.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2VTY8@28216|Betaproteobacteria,4AEDD@80864|Comamonadaceae	28216|Betaproteobacteria	J	PFAM RNA-binding S4 domain protein	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD3_k127_371084_2	316055.RPE_3841	2.026e-158	520.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2TRA4@28211|Alphaproteobacteria,3JSPN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_371084_6	1120999.JONM01000001_gene1086	1.139e-82	280.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2VI7G@28216|Betaproteobacteria,2KQBQ@206351|Neisseriales	206351|Neisseriales	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD3_k127_371084_7	1348657.M622_13520	3.712e-59	213.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,2KW8E@206389|Rhodocyclales	206389|Rhodocyclales	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD3_k127_371084_8	1524467.IV04_05675	3.801e-57	222.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,1S2K3@1236|Gammaproteobacteria,402KN@613|Serratia	1236|Gammaproteobacteria	O	Glutathione S-transferase	yliJ	GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD3_k127_371084_1	1198452.Jab_1c01050	1.445e-195	615.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,472CJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD3_k127_3769241_17	267608.RSc0541	1.168e-75	260.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,1K4AM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD3_k127_3769241_12	926550.CLDAP_23670	4.491e-100	344.0	COG0483@1|root,COG0483@2|Bacteria,2G7NN@200795|Chloroflexi	200795|Chloroflexi	G	PFAM inositol monophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
HKD3_k127_3769241_33	1266914.ATUK01000010_gene1115	3.223e-14	81.0	COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,1SG9J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_3769241_0	983917.RGE_13120	0.0	1266.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1KJT4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD3_k127_3769241_27	614083.AWQR01000011_gene2354	1.223e-39	172.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2VUU6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_3769241_22	172088.AUGA01000032_gene1510	1.844e-48	177.0	COG5470@1|root,COG5470@2|Bacteria,1PJI2@1224|Proteobacteria,2UHC0@28211|Alphaproteobacteria,3K5UN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_3769241_16	75379.Tint_0153	3.178e-76	256.0	COG0346@1|root,COG0346@2|Bacteria,1N0WM@1224|Proteobacteria,2VSM4@28216|Betaproteobacteria,1KM7J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD3_k127_3769241_8	543728.Vapar_5779	4.073e-113	377.0	COG0500@1|root,COG2226@2|Bacteria,1RDD9@1224|Proteobacteria,2VS1S@28216|Betaproteobacteria,4AG02@80864|Comamonadaceae	28216|Betaproteobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_3769241_28	1229203.KI301992_gene2602	1.844e-33	133.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HKD3_k127_3769241_18	795666.MW7_0950	4.418e-74	256.0	COG3832@1|root,COG3832@2|Bacteria,1RCZK@1224|Proteobacteria,2VR7G@28216|Betaproteobacteria,1K1RE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD3_k127_3769241_23	1384054.N790_06795	7.533e-48	177.0	COG3791@1|root,COG3791@2|Bacteria,1N023@1224|Proteobacteria,1SAQH@1236|Gammaproteobacteria,1X79M@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_3769241_26	85643.Tmz1t_1811	2.809e-42	162.0	2C2IY@1|root,2ZM9A@2|Bacteria,1P46K@1224|Proteobacteria,2W5FJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3769241_31	113395.AXAI01000007_gene1224	1.41e-20	96.0	COG2329@1|root,COG2329@2|Bacteria,1Q4HA@1224|Proteobacteria,2UN5H@28211|Alphaproteobacteria,3K6BI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD3_k127_3769241_25	243231.GSU0172	3.884e-43	164.0	COG3324@1|root,COG3324@2|Bacteria,1N7Q5@1224|Proteobacteria,42Y00@68525|delta/epsilon subdivisions,2WT7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD3_k127_3769241_29	292415.Tbd_1063	2.128e-27	119.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2VV6N@28216|Betaproteobacteria,1KTC2@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
HKD3_k127_3769241_13	1265502.KB905932_gene1907	9.416e-96	325.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,4A9X2@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD3_k127_3769241_3	62928.azo2862	2.068e-166	532.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KW6R@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD3_k127_3769241_5	1095769.CAHF01000011_gene2300	2.287e-126	411.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2W98D@28216|Betaproteobacteria,476N1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD3_k127_3769241_7	1095769.CAHF01000011_gene2301	7.521e-116	384.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HKD3_k127_3769241_24	1157708.KB907454_gene2897	4.941e-47	173.0	COG3631@1|root,COG3631@2|Bacteria,1RHRD@1224|Proteobacteria,2VSXM@28216|Betaproteobacteria,4AENZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_3769241_20	1496688.ER33_13120	8.869e-66	233.0	COG1881@1|root,COG1881@2|Bacteria,1GEHG@1117|Cyanobacteria	1117|Cyanobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD3_k127_3769241_10	671143.DAMO_0362	3.009e-107	357.0	COG2837@1|root,COG2837@2|Bacteria	2|Bacteria	P	iron assimilation	dyp	-	-	ko:K07223	-	-	-	-	ko00000	-	-	-	Dyp_perox
HKD3_k127_3769241_2	266264.Rmet_2055	8.777e-188	598.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2VH0F@28216|Betaproteobacteria,1K36P@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM extracellular solute-binding protein family 1	ugpB	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
HKD3_k127_3769241_4	296591.Bpro_0856	1.253e-131	425.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2VH0I@28216|Betaproteobacteria,4ACEG@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	ugpA	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HKD3_k127_3769241_6	1217718.ALOU01000019_gene2720	4.994e-120	392.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,1K0AM@119060|Burkholderiaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HKD3_k127_3769241_11	264198.Reut_A2048	5.964e-105	359.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2VKF6@28216|Betaproteobacteria,1K1M5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	glycerophosphoryl diester phosphodiesterase	ugpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD3_k127_3769241_1	1282362.AEAC466_21360	3.81e-214	675.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2KFG4@204458|Caulobacterales	204458|Caulobacterales	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD3_k127_3769241_34	1458427.BAWN01000011_gene643	4.496e-10	73.0	COG1734@1|root,COG1734@2|Bacteria,1NA1P@1224|Proteobacteria,2VX46@28216|Betaproteobacteria,4AFF7@80864|Comamonadaceae	28216|Betaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD3_k127_3769241_9	375286.mma_1912	1.17e-109	373.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria,473Y5@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	impB/mucB/samB family	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HKD3_k127_3769241_21	375286.mma_1911	4.494e-64	228.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria,4749I@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	imuA	-	-	ko:K13053,ko:K14160	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	SulA
HKD3_k127_3769241_14	123899.JPQP01000001_gene1649	3.197e-82	289.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VHTZ@28216|Betaproteobacteria,3T338@506|Alcaligenaceae	28216|Betaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD3_k127_3769241_30	887898.HMPREF0551_1081	9.705e-26	125.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,2VW1R@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_3769241_19	1286631.X805_35440	3.267e-70	249.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria,1KM3D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_3769241_15	1349767.GJA_1949	1.135e-79	267.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,472V4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	DAO,ETF_QO,FAD_binding_2,NAD_binding_8
HKD3_k127_3782363_23	85643.Tmz1t_1403	9.992e-41	158.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,2KUBF@206389|Rhodocyclales	206389|Rhodocyclales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD3_k127_3782363_13	1265502.KB905938_gene2465	7.183e-93	309.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,4AAIY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HKD3_k127_3782363_20	522306.CAP2UW1_2701	4.852e-54	194.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,1KQRG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD3_k127_3782363_15	1144342.PMI40_02754	1.354e-86	306.0	COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,2VIX1@28216|Betaproteobacteria,472NA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	NIF3 (NGG1p interacting factor 3)	ybgI	-	-	-	-	-	-	-	-	-	-	-	NIF3
HKD3_k127_3782363_2	264198.Reut_A3096	8.979e-148	479.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,1K0VU@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	degQ	-	-	ko:K04691,ko:K04772	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_3782363_6	522306.CAP2UW1_4064	2.938e-124	433.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD3_k127_3782363_9	887898.HMPREF0551_2540	7.172e-112	366.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,1K08P@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD3_k127_3782363_26	522306.CAP2UW1_4043	6.452e-25	112.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,1KR6J@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD3_k127_3782363_25	264198.Reut_A3100	1.296e-25	108.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD3_k127_3782363_22	85643.Tmz1t_0912	1.173e-43	166.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales	206389|Rhodocyclales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
HKD3_k127_3782363_21	420662.Mpe_A0838	1.033e-43	164.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,1KM5H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
HKD3_k127_3782363_18	1231391.AMZF01000010_gene1665	2.085e-58	207.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,3T3SJ@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HKD3_k127_3782363_7	62928.azo3344	1.467e-123	413.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,2KV5N@206389|Rhodocyclales	206389|Rhodocyclales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD3_k127_3782363_5	1123487.KB892867_gene902	1.675e-128	415.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,2KUM6@206389|Rhodocyclales	206389|Rhodocyclales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD3_k127_3782363_12	94624.Bpet0135	6.879e-94	315.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,3T247@506|Alcaligenaceae	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD3_k127_3782363_11	887898.HMPREF0551_2531	1.414e-99	329.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,1K2PX@119060|Burkholderiaceae	28216|Betaproteobacteria	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD3_k127_3782363_3	977880.RALTA_A2874	1.012e-134	458.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,1K1VS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_3782363_0	123899.JPQP01000003_gene1374	3.711e-198	628.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,3T2YB@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD3_k127_3782363_14	999541.bgla_1g03750	8.314e-87	310.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,1K2AQ@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD3_k127_3782363_1	887898.HMPREF0551_2528	1.089e-190	605.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,1K26U@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD3_k127_3782363_24	266265.Bxe_A0395	3.955e-31	124.0	COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,1K9F0@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the BolA IbaG family	yrbA	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD3_k127_3782363_8	1198452.Jab_1c00970	3.116e-118	388.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,472AY@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD3_k127_3782363_4	667632.KB890170_gene3708	7.6e-129	419.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,1JZUI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	ABC transporter	ybhF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3782363_28	1502852.FG94_01641	2.257e-07	62.0	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,2VXUB@28216|Betaproteobacteria,4757N@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
HKD3_k127_3782363_16	395495.Lcho_3390	3.853e-68	241.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,1KKN9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	toluene tolerance	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD3_k127_3782363_19	795666.MW7_3287	3.558e-55	219.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K1I1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD3_k127_3782363_17	381666.H16_A3425	2.067e-65	227.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,1K3MD@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	mlaD	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD3_k127_3782363_10	1038869.AXAN01000030_gene3998	1.079e-107	358.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,1K22X@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	ABC transporter permease	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD3_k127_3782363_27	882378.RBRH_02304	4.576e-24	103.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,1K0GE@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	abc transporter	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_3785274_2	502025.Hoch_1248	6.652e-55	202.0	COG2050@1|root,COG2050@2|Bacteria,1QVFN@1224|Proteobacteria	1224|Proteobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD3_k127_3785274_0	1123504.JQKD01000004_gene5043	0.0	1081.0	COG0365@1|root,COG0365@2|Bacteria,1MXDK@1224|Proteobacteria,2VIAE@28216|Betaproteobacteria,4ABQD@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM AMP-dependent synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD3_k127_3785274_1	296591.Bpro_5291	9.708e-226	705.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VPF7@28216|Betaproteobacteria,4AG9A@80864|Comamonadaceae	28216|Betaproteobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_3785274_3	1121271.AUCM01000003_gene1665	2.643e-41	154.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TT8N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD3_k127_3789169_3	859657.RPSI07_mp1534	1.097e-143	462.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJM2@28216|Betaproteobacteria,1K3CW@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_3789169_1	1207063.P24_18002	3.054e-180	589.0	COG0624@1|root,COG0624@2|Bacteria,1MW2W@1224|Proteobacteria,2TQYZ@28211|Alphaproteobacteria,2JPP8@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_3789169_2	1205680.CAKO01000037_gene1234	2.451e-168	537.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales	204441|Rhodospirillales	S	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_3789169_7	748247.AZKH_2953	4.705e-78	274.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VI5H@28216|Betaproteobacteria,2KX2B@206389|Rhodocyclales	206389|Rhodocyclales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_3789169_13	1131814.JAFO01000001_gene2109	4.418e-18	86.0	2EGQC@1|root,33AGI@2|Bacteria,1NGA3@1224|Proteobacteria,2UKAV@28211|Alphaproteobacteria,3F20N@335928|Xanthobacteraceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PsiF_repeat
HKD3_k127_3789169_4	1163617.SCD_n00464	1.338e-85	300.0	28Q1D@1|root,2ZCJS@2|Bacteria,1RF11@1224|Proteobacteria,2VQZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3789169_6	1454004.AW11_01331	2.381e-78	269.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VMVD@28216|Betaproteobacteria	28216|Betaproteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
HKD3_k127_3789169_5	1454004.AW11_01332	5.73e-81	275.0	COG2191@1|root,COG2191@2|Bacteria,1RD60@1224|Proteobacteria,2VR8B@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Formylmethanofuran dehydrogenase, subunit e	-	-	-	-	-	-	-	-	-	-	-	-	FmdE
HKD3_k127_3789169_10	1454004.AW11_01333	1.212e-40	173.0	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2VUNK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3789169_8	292564.Cyagr_1794	3.697e-65	235.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03668,ko:K09914	-	-	-	-	ko00000	-	-	-	META
HKD3_k127_3789169_15	1452718.JBOY01000055_gene1748	3.76e-06	54.0	2DNJV@1|root,32UJ6@2|Bacteria,1N4SS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3789169_9	1286171.EAL2_c07930	1.441e-48	179.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,25W6Q@186806|Eubacteriaceae	186801|Clostridia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD3_k127_3789169_11	309799.DICTH_0757	2.953e-30	138.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
HKD3_k127_3789169_12	1047013.AQSP01000139_gene2394	2.229e-24	119.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
HKD3_k127_3789169_14	861299.J421_0890	3.506e-07	60.0	28YF5@1|root,2ZK9H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3789169_0	760192.Halhy_5331	8.331e-262	813.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,4NEHE@976|Bacteroidetes,1INV9@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD3_k127_3812365_3	207954.MED92_11104	6.829e-199	623.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	small subunit	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	NiFe_hyd_SSU_C,Oxidored_q6
HKD3_k127_3812365_13	1380394.JADL01000009_gene3355	1.498e-42	162.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,2JT6Z@204441|Rhodospirillales	204441|Rhodospirillales	O	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
HKD3_k127_3812365_15	765912.Thimo_2269	4.822e-37	152.0	2C9YT@1|root,31Z2V@2|Bacteria,1RHIU@1224|Proteobacteria,1S6G3@1236|Gammaproteobacteria,1WYT4@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812365_7	768671.ThimaDRAFT_4701	9.375e-134	451.0	COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD3_k127_3812365_18	765912.Thimo_2267	5.84e-23	102.0	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,1SBV1@1236|Gammaproteobacteria,1WZ48@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase proteolipid subunit family	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD3_k127_3812365_20	765912.Thimo_2266	1.151e-09	72.0	COG1436@1|root,COG1436@2|Bacteria,1NFVS@1224|Proteobacteria,1SF77@1236|Gammaproteobacteria,1WZH0@135613|Chromatiales	135613|Chromatiales	C	ATP synthase (F/14-kDa) subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
HKD3_k127_3812365_19	1249627.D779_2946	1.694e-22	108.0	2DXMK@1|root,32V3Q@2|Bacteria,1N6HJ@1224|Proteobacteria,1SB4I@1236|Gammaproteobacteria,1WZ1G@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812365_1	2340.JV46_14290	1.662e-236	759.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD3_k127_3812365_4	2340.JV46_14280	7.349e-197	626.0	COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_ab
HKD3_k127_3812365_14	1249627.D779_2949	2.3e-38	164.0	COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD3_k127_3812365_16	983917.RGE_33810	7.539e-35	147.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD3_k127_3812365_17	1255043.TVNIR_2063	1.533e-26	122.0	COG0664@1|root,COG0664@2|Bacteria,1RC7W@1224|Proteobacteria,1S2ZD@1236|Gammaproteobacteria,1WY6E@135613|Chromatiales	135613|Chromatiales	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD3_k127_3812365_6	404589.Anae109_0596	2.066e-139	458.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,42MJI@68525|delta/epsilon subdivisions,2WJQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	6-phosphogluconate dehydrogenase (decarboxylating)	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2620	6PGD,NAD_binding_2
HKD3_k127_3812365_9	388051.AUFE01000094_gene31	1.85e-131	441.0	COG1028@1|root,COG1028@2|Bacteria,1NYXI@1224|Proteobacteria,2VPQD@28216|Betaproteobacteria,1K2B2@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_3812365_8	388051.AUFE01000094_gene30	9.035e-133	437.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_3812365_5	748247.AZKH_1935	2.034e-193	609.0	COG3246@1|root,COG3246@2|Bacteria,1MXGN@1224|Proteobacteria,2VH01@28216|Betaproteobacteria	28216|Betaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD3_k127_3812365_12	264198.Reut_B4714	8.697e-53	192.0	COG0599@1|root,COG0599@2|Bacteria,1N0Z6@1224|Proteobacteria,2W2N6@28216|Betaproteobacteria,1K5AV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD3_k127_3812365_10	1366050.N234_35015	4.761e-117	389.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2VP0I@28216|Betaproteobacteria,1K45R@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_3812365_0	397945.Aave_4497	3.527e-296	929.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,4ABF6@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	aas	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	Acyltransferase,MFS_1
HKD3_k127_3812365_2	765912.Thimo_3289	1.627e-199	634.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales	135613|Chromatiales	GM	nucleoside-diphosphate sugar epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD3_k127_3812365_11	1121937.AUHJ01000023_gene198	6.931e-89	296.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,465NQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD3_k127_3820683_4	1123367.C666_17685	1.605e-60	213.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJ2@28216|Betaproteobacteria,2KUZM@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_3820683_2	1100720.ALKN01000045_gene461	1.063e-120	394.0	COG0491@1|root,COG0491@2|Bacteria,1MW35@1224|Proteobacteria,2VPNG@28216|Betaproteobacteria,4AH40@80864|Comamonadaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_3820683_3	402881.Plav_3076	1.749e-117	396.0	COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,2TRMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	MA20_16375	-	-	-	-	-	-	-	-	-	-	-	APH
HKD3_k127_3820683_1	1382303.JPOM01000001_gene1987	1.728e-235	752.0	COG1960@1|root,COG1960@2|Bacteria,1MWUU@1224|Proteobacteria,2TT47@28211|Alphaproteobacteria,2KFN1@204458|Caulobacterales	204458|Caulobacterales	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_3820683_0	709797.CSIRO_1408	1.445e-286	905.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2TRV7@28211|Alphaproteobacteria,3JRYR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	MA20_06730	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
HKD3_k127_3849319_15	1266909.AUAG01000049_gene666	1.391e-07	55.0	COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG4968 Tfp pilus assembly protein PilE	pilE	-	-	ko:K02655	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
HKD3_k127_3849319_1	887898.HMPREF0551_2058	1.923e-259	818.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,1K19K@119060|Burkholderiaceae	28216|Betaproteobacteria	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_3849319_17	32057.KB217478_gene5882	0.0002138	56.0	COG5533@1|root,COG5533@2|Bacteria,1G67R@1117|Cyanobacteria,1HSQW@1161|Nostocales	1117|Cyanobacteria	O	Opioid growth factor receptor (OGFr) conserved region	-	-	-	-	-	-	-	-	-	-	-	-	OGFr_N
HKD3_k127_3849319_2	1286093.C266_14517	5.032e-221	720.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2VMGW@28216|Betaproteobacteria,1K1FS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	penicillin-binding protein	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HKD3_k127_3849319_0	381666.H16_A3676	0.0	1755.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,1K2DM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM alpha-2-macroglobulin domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
HKD3_k127_3849319_16	1150469.RSPPHO_00606	2.343e-07	60.0	2EJAI@1|root,33D1Q@2|Bacteria,1NHDC@1224|Proteobacteria,2UVXU@28211|Alphaproteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD3_k127_3849319_3	360910.BAV3210	1.389e-199	645.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,3T1N4@506|Alcaligenaceae	28216|Betaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD3_k127_3849319_7	1120999.JONM01000002_gene861	5.409e-160	526.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,2KPF4@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD3_k127_3849319_10	365046.Rta_15110	1.725e-46	177.0	COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,2VKFZ@28216|Betaproteobacteria,4A9VV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF599	-	-	-	-	-	-	-	-	-	-	-	-	DUF599
HKD3_k127_3849319_13	795666.MW7_1325	1.004e-12	77.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10,NmrA
HKD3_k127_3849319_4	1123504.JQKD01000005_gene4762	1.291e-183	592.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2VH34@28216|Betaproteobacteria,4ABJA@80864|Comamonadaceae	28216|Betaproteobacteria	EH	PFAM Thiamine pyrophosphate	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
HKD3_k127_3849319_12	932678.THERU_06400	7.912e-16	82.0	COG4654@1|root,COG4654@2|Bacteria,2G5BC@200783|Aquificae	200783|Aquificae	C	PFAM cytochrome c class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD3_k127_3849319_9	296591.Bpro_0629	7.081e-55	202.0	28ME7@1|root,2ZARX@2|Bacteria,1R90X@1224|Proteobacteria,2VNB6@28216|Betaproteobacteria,4AA7V@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_3849319_5	748247.AZKH_4464	3.068e-179	574.0	COG2203@1|root,COG3576@1|root,COG2203@2|Bacteria,COG3576@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,2KXR2@206389|Rhodocyclales	206389|Rhodocyclales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
HKD3_k127_3849319_11	497321.C664_06873	1.947e-31	140.0	COG3576@1|root,COG3576@2|Bacteria,1N8Z5@1224|Proteobacteria,2VVVW@28216|Betaproteobacteria,2KX6P@206389|Rhodocyclales	206389|Rhodocyclales	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3849319_6	426114.THI_0274	2.954e-173	558.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2VI2E@28216|Betaproteobacteria,1KJXC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	calB	-	1.2.1.3,1.2.1.68	ko:K00128,ko:K00154	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_3849319_8	1450525.JATV01000002_gene2024	1.063e-143	474.0	COG2223@1|root,COG2223@2|Bacteria,4NJ57@976|Bacteroidetes,1HWYX@117743|Flavobacteriia,2NV1N@237|Flavobacterium	976|Bacteroidetes	P	Transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1,MgtE_N
HKD3_k127_3849319_14	397945.Aave_0373	5.33e-08	54.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,4ADIK@80864|Comamonadaceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD3_k127_385978_0	557598.LHK_00831	3.965e-201	640.0	COG2244@1|root,COG2244@2|Bacteria,1MUMD@1224|Proteobacteria,2VTCJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
HKD3_k127_385978_2	557598.LHK_00832	2.32e-136	466.0	COG0438@1|root,COG0438@2|Bacteria,1RAXB@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD3_k127_385978_3	557598.LHK_00833	4.265e-112	390.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,2VPIW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the glycosyltransferase 26 family	tagA	-	2.4.1.187	ko:K05946,ko:K13660	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,STAS_2
HKD3_k127_385978_1	557598.LHK_00834	8.976e-153	496.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1QY3G@1224|Proteobacteria	1224|Proteobacteria	DM	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3970708_7	1123368.AUIS01000028_gene1327	6.558e-60	209.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3970708_1	1123368.AUIS01000028_gene1326	3.905e-250	796.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_3970708_3	1123368.AUIS01000028_gene1325	1.087e-92	342.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
HKD3_k127_3970708_10	388051.AUFE01000001_gene2122	1.492e-50	197.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1K8SG@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
HKD3_k127_3970708_12	1125973.JNLC01000015_gene3368	7.297e-43	165.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,3JR9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HKD3_k127_3970708_5	1454004.AW11_02927	2.161e-70	252.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,1KQIC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD3_k127_3970708_2	323848.Nmul_A1212	5.232e-112	366.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,3729C@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD3_k127_3970708_9	261292.Nit79A3_1271	7.981e-54	198.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3731F@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD3_k127_3970708_0	420662.Mpe_A1211	8.562e-263	824.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,1KIYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	cytochrome C	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD3_k127_3970708_6	1116472.MGMO_173c00070	3.614e-61	217.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1XF10@135618|Methylococcales	135618|Methylococcales	CO	TIGRFAM periplasmic protein thiol	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	Redoxin
HKD3_k127_3970708_13	1304883.KI912532_gene1024	2.291e-33	136.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,2KX2W@206389|Rhodocyclales	206389|Rhodocyclales	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HKD3_k127_3970708_4	398578.Daci_3974	6.024e-86	314.0	COG2807@1|root,COG2807@2|Bacteria,1QU85@1224|Proteobacteria,2VNPC@28216|Betaproteobacteria,4AC7D@80864|Comamonadaceae	28216|Betaproteobacteria	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_3970708_14	614083.AWQR01000011_gene2378	2.539e-25	118.0	COG5436@1|root,COG5436@2|Bacteria	2|Bacteria	S	integral membrane protein	MA20_15590	-	-	-	-	-	-	-	-	-	-	-	DUF1254
HKD3_k127_3970708_11	614083.AWQR01000011_gene2379	1.583e-50	185.0	COG5402@1|root,COG5402@2|Bacteria,1N26C@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1214)	MA20_15585	-	-	-	-	-	-	-	-	-	-	-	DUF1214
HKD3_k127_3970708_8	323848.Nmul_A0905	8.375e-56	201.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2VR5Q@28216|Betaproteobacteria,372T2@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD3_k127_4031279_29	502025.Hoch_1248	3.046e-05	49.0	COG2050@1|root,COG2050@2|Bacteria,1QVFN@1224|Proteobacteria	1224|Proteobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD3_k127_4031279_30	1123253.AUBD01000001_gene1647	0.0001663	49.0	COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,1SDB2@1236|Gammaproteobacteria,1X717@135614|Xanthomonadales	135614|Xanthomonadales	S	Poly(hydroxyalcanoate) granule associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD3_k127_4031279_26	685727.REQ_44210	3.243e-16	89.0	COG1309@1|root,COG1309@2|Bacteria,2GMX0@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_4031279_15	1282876.BAOK01000001_gene3239	3.897e-107	377.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,4BPZE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	MA20_32380	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_4031279_21	1158292.JPOE01000002_gene2920	4.663e-45	168.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2VSYU@28216|Betaproteobacteria,1KM8J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Carboxymuconolactone decarboxylase family	pcaC	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,CMD
HKD3_k127_4031279_12	1123060.JONP01000007_gene5121	4.466e-115	376.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria,2JRKC@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_4031279_10	1123060.JONP01000011_gene3109	6.18e-127	415.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TRDC@28211|Alphaproteobacteria,2JQ8G@204441|Rhodospirillales	204441|Rhodospirillales	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HKD3_k127_4031279_3	331869.BAL199_01709	2.561e-205	649.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,4BRUK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Amidase	MA20_32360	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_4031279_23	1041142.ATTP01000042_gene5400	1.881e-35	155.0	COG1846@1|root,COG1846@2|Bacteria,1RCY7@1224|Proteobacteria,2UAR3@28211|Alphaproteobacteria,4BF7K@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	hpaR	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD3_k127_4031279_0	1082933.MEA186_21449	4.786e-237	738.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43N4V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD3_k127_4031279_16	536019.Mesop_0700	1.824e-98	329.0	COG1011@1|root,COG1011@2|Bacteria,1N73G@1224|Proteobacteria,2TVJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD3_k127_4031279_2	398525.KB900701_gene4023	1.083e-222	700.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3JS1H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	puuC	-	1.2.1.3,1.2.1.99	ko:K00128,ko:K09472	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00136	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R07417,R07418,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_4031279_20	887062.HGR_04828	7.232e-53	213.0	COG1073@1|root,COG1073@2|Bacteria,1RFAF@1224|Proteobacteria,2WERU@28216|Betaproteobacteria,4AF1F@80864|Comamonadaceae	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD3_k127_4031279_11	1100720.ALKN01000040_gene2177	2.923e-123	420.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VPR2@28216|Betaproteobacteria,4ADP5@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_4031279_18	404589.Anae109_0028	2.923e-94	337.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_4031279_1	316055.RPE_1960	1.1e-224	720.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,3JQUM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD3_k127_4031279_6	522306.CAP2UW1_1620	8.871e-193	614.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2VJXC@28216|Betaproteobacteria,1KQNM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_4031279_8	1538295.JY96_07450	2.076e-178	584.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,1KJ9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD3_k127_4031279_19	290397.Adeh_2306	8.504e-74	257.0	COG0300@1|root,COG0300@2|Bacteria,1QV54@1224|Proteobacteria,42UFF@68525|delta/epsilon subdivisions,2WQJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.105	ko:K15734	ko00830,map00830	-	R02124	RC00649	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD3_k127_4031279_22	522306.CAP2UW1_2961	3.986e-37	145.0	COG2010@1|root,COG2010@2|Bacteria,1NAGW@1224|Proteobacteria,2VW71@28216|Betaproteobacteria	28216|Betaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_4031279_24	1304883.KI912532_gene2876	2.042e-32	135.0	COG2010@1|root,COG2010@2|Bacteria,1NAGW@1224|Proteobacteria,2VW71@28216|Betaproteobacteria,2KZ6Z@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4031279_13	1163617.SCD_n00016	4.823e-114	379.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD3_k127_4031279_9	228405.HNE_3277	3.645e-129	424.0	COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria,43ZF7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	hydrolase NrgC	-	-	1.14.13.235	ko:K22027	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HKD3_k127_4031279_28	595537.Varpa_5438	1.725e-12	71.0	2CCVE@1|root,333BC@2|Bacteria,1NEM8@1224|Proteobacteria,2VVY4@28216|Betaproteobacteria,4AIDG@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4031279_5	1123504.JQKD01000006_gene1520	2.788e-194	622.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VIHU@28216|Betaproteobacteria,4ABD5@80864|Comamonadaceae	28216|Betaproteobacteria	CH	PFAM monooxygenase FAD-binding	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD3_k127_4031279_14	1333998.M2A_2254	2.981e-109	358.0	COG1028@1|root,COG1028@2|Bacteria,1MXQR@1224|Proteobacteria,2TW65@28211|Alphaproteobacteria,4BSDZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_4031279_17	595537.Varpa_5262	1.314e-95	317.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2VMYY@28216|Betaproteobacteria,4ADCN@80864|Comamonadaceae	28216|Betaproteobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_4031279_4	1429916.X566_16140	6.616e-204	640.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TSA0@28211|Alphaproteobacteria,3JQM2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Belongs to the thiolase family	MA20_06750	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_4031279_25	883126.HMPREF9710_00545	2.16e-31	131.0	COG1670@1|root,COG1670@2|Bacteria,1QVH4@1224|Proteobacteria,2VQSE@28216|Betaproteobacteria,47477@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_4031279_7	1126627.BAWE01000004_gene2840	2.71e-182	578.0	COG1804@1|root,COG1804@2|Bacteria,1MVK4@1224|Proteobacteria,2TWRE@28211|Alphaproteobacteria,3JSRH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_17775	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD3_k127_4134012_18	1217718.ALOU01000005_gene1438	1.591e-90	302.0	COG0406@1|root,COG0406@2|Bacteria,1RB0S@1224|Proteobacteria,2VJR8@28216|Betaproteobacteria,1K60Y@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD3_k127_4134012_11	1000565.METUNv1_01232	2.524e-129	419.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,2KUXA@206389|Rhodocyclales	206389|Rhodocyclales	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD3_k127_4134012_25	62928.azo2923	3.561e-67	249.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2VJYN@28216|Betaproteobacteria,2KUWT@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
HKD3_k127_4134012_21	1411123.JQNH01000001_gene582	4.297e-77	269.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2TUHN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type tungstate transport system, periplasmic component	MA20_34300	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD3_k127_4134012_24	460265.Mnod_1400	3.214e-69	248.0	COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2TVB8@28211|Alphaproteobacteria,1JTJV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	regulatory protein LysR	-	-	-	ko:K07219	-	-	-	-	ko00000	-	-	-	HTH_1,HTH_17,PBP_like
HKD3_k127_4134012_7	1158292.JPOE01000005_gene217	7.214e-164	530.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VSBW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD3_k127_4134012_4	338969.Rfer_0825	4.368e-178	568.0	COG0277@1|root,COG0277@2|Bacteria,1N4UQ@1224|Proteobacteria,2W1U4@28216|Betaproteobacteria,4AHE1@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HKD3_k127_4134012_35	204773.HEAR1382	1.085e-24	113.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,476C4@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
HKD3_k127_4134012_2	987059.RBXJA2T_12017	8.197e-192	626.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VMJZ@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	TIGRFAM acyltransferase, WS DGAT MGAT	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_4134012_9	977880.RALTA_B0414	2.901e-143	473.0	COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,2VNYM@28216|Betaproteobacteria,1KBVW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD3_k127_4134012_17	1231391.AMZF01000018_gene1842	6.565e-97	340.0	COG0600@1|root,COG0600@2|Bacteria,1NSKG@1224|Proteobacteria,2VK0S@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_4134012_20	391735.Veis_0385	2.723e-78	282.0	COG0600@1|root,COG0600@2|Bacteria,1R4XS@1224|Proteobacteria,2VMMX@28216|Betaproteobacteria,4ACHE@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_4134012_13	1157708.KB907451_gene4593	9.122e-110	361.0	COG1116@1|root,COG1116@2|Bacteria,1R53G@1224|Proteobacteria,2VPGE@28216|Betaproteobacteria,4AD39@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_4134012_12	1123504.JQKD01000042_gene4680	1.632e-110	367.0	COG0715@1|root,COG0715@2|Bacteria,1NS0V@1224|Proteobacteria,2VNDV@28216|Betaproteobacteria,4AAYW@80864|Comamonadaceae	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD3_k127_4134012_33	626887.J057_16215	2.252e-36	155.0	COG0515@1|root,COG2020@1|root,COG0515@2|Bacteria,COG2020@2|Bacteria,1RJNV@1224|Proteobacteria,1SGB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD3_k127_4134012_29	742823.HMPREF9465_00478	6.864e-56	208.0	COG0515@1|root,COG0515@2|Bacteria,1N75K@1224|Proteobacteria,2W05P@28216|Betaproteobacteria,4PQYC@995019|Sutterellaceae	28216|Betaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4134012_16	983917.RGE_32950	1.377e-98	328.0	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,2VHDT@28216|Betaproteobacteria,1KN0J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
HKD3_k127_4134012_14	765911.Thivi_0092	8.563e-106	348.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1WXBT@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD3_k127_4134012_1	1002809.SSIL_2408	2.381e-230	730.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,26DUZ@186818|Planococcaceae	91061|Bacilli	E	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_4134012_15	316055.RPE_3198	1.754e-100	337.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria,3JYK9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD3_k127_4134012_8	316055.RPE_3197	2.264e-143	460.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,2U1A9@28211|Alphaproteobacteria,3JXC0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD3_k127_4134012_26	1001585.MDS_4052	8.825e-66	236.0	COG1028@1|root,COG1028@2|Bacteria,1QTU9@1224|Proteobacteria,1RRP9@1236|Gammaproteobacteria,1YDX1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_4134012_5	296591.Bpro_3466	8.559e-178	561.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2VI04@28216|Betaproteobacteria,4AASZ@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_1,Meth_synt_2
HKD3_k127_4134012_6	1101190.ARWB01000001_gene3242	2.69e-175	559.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,36XQW@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PBP
HKD3_k127_4134012_31	1380355.JNIJ01000004_gene2837	1.978e-46	190.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2TSFV@28211|Alphaproteobacteria,3JRG8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	ko:K17230	ko00920,ko01120,map00920,map01120	-	R09499	-	ko00000,ko00001	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_4134012_27	1408164.MOLA814_00378	6.038e-63	222.0	2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2VRZH@28216|Betaproteobacteria,1KQZI@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
HKD3_k127_4134012_19	1382306.JNIM01000001_gene1024	2.069e-88	326.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD3_k127_4134012_0	1382306.JNIM01000001_gene1023	8.246e-268	869.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD3_k127_4134012_28	1382306.JNIM01000001_gene1022	1.399e-58	210.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD3_k127_4134012_32	258594.RPA3661	1.723e-36	149.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2U05J@28211|Alphaproteobacteria,3JT6M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	HD domain	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
HKD3_k127_4134012_37	551789.ATVJ01000001_gene547	2.858e-22	98.0	2EIMJ@1|root,33CCU@2|Bacteria,1NMXZ@1224|Proteobacteria,2U04I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4134012_22	338969.Rfer_1518	8.785e-75	264.0	COG2344@1|root,COG2344@2|Bacteria,1NXDK@1224|Proteobacteria,2VN87@28216|Betaproteobacteria,4ABCB@80864|Comamonadaceae	28216|Betaproteobacteria	E	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate	ddh	-	1.4.1.16	ko:K03340	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00526	R02755	RC00006	ko00000,ko00001,ko00002,ko01000	-	-	-	DAPDH_C,DapB_N
HKD3_k127_4134012_10	1242864.D187_008484	1.732e-133	436.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD3_k127_4134012_23	983917.RGE_00340	1.041e-71	270.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,1KKYD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
HKD3_k127_4134012_30	1036674.A28LD_0860	1.743e-53	200.0	COG2030@1|root,COG2030@2|Bacteria,1RAAG@1224|Proteobacteria,1S1Z8@1236|Gammaproteobacteria,2QG41@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD3_k127_4134012_36	420662.Mpe_A0493	2.663e-22	101.0	COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,1KMMC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Copper binding periplasmic protein CusF	-	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
HKD3_k127_4134012_34	301.JNHE01000022_gene2592	8.072e-25	104.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,1S5Y8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD3_k127_416380_25	440512.C211_14141	4.907e-24	113.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,1RPKP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cobalamin synthesis protein, P47K	yeiR	GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
HKD3_k127_416380_1	864051.BurJ1DRAFT_1528	4.734e-270	846.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2VJ2Q@28216|Betaproteobacteria,1KKH9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	TRAP-type mannitol chloroaromatic compound transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_416380_16	1095769.CAHF01000018_gene821	2.066e-90	304.0	COG4664@1|root,COG4665@1|root,COG4664@2|Bacteria,COG4665@2|Bacteria,1R4MZ@1224|Proteobacteria,2VJ2Q@28216|Betaproteobacteria,47290@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_416380_4	404589.Anae109_2924	2.953e-180	571.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,42NEN@68525|delta/epsilon subdivisions,2WKJP@28221|Deltaproteobacteria,2Z1DV@29|Myxococcales	28221|Deltaproteobacteria	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_416380_18	887898.HMPREF0551_2151	1.393e-85	295.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,1K3GV@119060|Burkholderiaceae	28216|Betaproteobacteria	T	response regulator	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
HKD3_k127_416380_3	887898.HMPREF0551_2150	4.454e-213	698.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria,1K1RB@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
HKD3_k127_416380_23	1266925.JHVX01000007_gene2282	6.015e-32	134.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,3731M@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
HKD3_k127_416380_11	264198.Reut_A3405	1.363e-116	403.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,1K1JQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD3_k127_416380_10	266265.Bxe_A4413	5.551e-148	473.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,1K02Z@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD3_k127_416380_12	76114.ebA2954	3.654e-108	361.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,2KVNV@206389|Rhodocyclales	206389|Rhodocyclales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD3_k127_416380_20	1095769.CAHF01000014_gene3141	1.511e-74	255.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,472GE@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD3_k127_416380_13	887898.HMPREF0551_2144	1.999e-105	353.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,1JZRZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_416380_14	76114.ebA2961	2.255e-99	337.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,2KUP7@206389|Rhodocyclales	206389|Rhodocyclales	LU	Rossmann fold nucleotide-binding protein involved in DNA uptake	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD3_k127_416380_0	887898.HMPREF0551_2142	0.0	1238.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1K0Y7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	SWIB,Topoisom_bac,Toprim,Toprim_Crpt
HKD3_k127_416380_21	887898.HMPREF0551_2141	2.553e-47	176.0	COG3703@1|root,COG3703@2|Bacteria,1RC84@1224|Proteobacteria,2VQ5T@28216|Betaproteobacteria,1K34F@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	-	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
HKD3_k127_416380_17	1268237.G114_10900	4.268e-86	299.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,1Y52X@135624|Aeromonadales	135624|Aeromonadales	P	membrane protein, TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD3_k127_416380_19	257310.BB1843	2.588e-82	285.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,3T1TF@506|Alcaligenaceae	28216|Betaproteobacteria	S	aromatic ring-opening dioxygenase	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD3_k127_416380_22	243159.AFE_1900	5.091e-36	154.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,2ND8Z@225057|Acidithiobacillales	225057|Acidithiobacillales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_416380_7	1100720.ALKN01000045_gene176	2.369e-156	503.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_416380_9	1123060.JONP01000011_gene3108	4.188e-149	491.0	COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,2TS7J@28211|Alphaproteobacteria,2JQWQ@204441|Rhodospirillales	204441|Rhodospirillales	P	PhoD-like phosphatase, N-terminal domain	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
HKD3_k127_416380_27	483219.LILAB_11005	1.831e-06	55.0	2AGT3@1|root,31715@2|Bacteria,1PY9G@1224|Proteobacteria,4356Q@68525|delta/epsilon subdivisions,2WZHV@28221|Deltaproteobacteria,2Z26I@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2917)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2917
HKD3_k127_416380_15	864051.BurJ1DRAFT_2430	2.462e-93	318.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VM7N@28216|Betaproteobacteria,1KNHT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	gcvA	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_416380_5	765420.OSCT_1549	1.22e-176	570.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,3771Y@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD3_k127_416380_2	323848.Nmul_A0956	3.315e-229	724.0	COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,372MX@32003|Nitrosomonadales	28216|Betaproteobacteria	G	BT1 family	-	-	-	-	-	-	-	-	-	-	-	-	BT1
HKD3_k127_416380_6	1177928.TH2_00330	2.83e-168	589.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JRKY@204441|Rhodospirillales	204441|Rhodospirillales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
HKD3_k127_416380_24	1348657.M622_17820	1.31e-27	133.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,Cu_amine_oxidN1,DUF4214
HKD3_k127_416380_8	864051.BurJ1DRAFT_3296	5.866e-154	497.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria	1224|Proteobacteria	S	Beta-lactamase domain protein	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD3_k127_416380_26	460265.Mnod_0152	1.155e-07	56.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,1JS1J@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_4213603_3	1144319.PMI16_00536	5.65e-166	527.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,47292@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD3_k127_4213603_8	977880.RALTA_A2291	5.625e-83	291.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria,1KD3S@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_4213603_11	999541.bgla_1g17190	6.121e-72	250.0	COG2816@1|root,COG2816@2|Bacteria,1REUJ@1224|Proteobacteria,2VRF4@28216|Betaproteobacteria,1K23S@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,Nudix_N_2
HKD3_k127_4213603_12	864051.BurJ1DRAFT_2117	1.864e-71	258.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1KNH5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.47,1.1.1.69,1.3.1.28	ko:K00034,ko:K00046,ko:K00059,ko:K00216	ko00030,ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01120,map01130,map01200,map01212	M00083,M00572	R01505,R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117,RC00534	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_4213603_10	614083.AWQR01000021_gene250	1.067e-74	258.0	COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2VN4R@28216|Betaproteobacteria,4ACPJ@80864|Comamonadaceae	28216|Betaproteobacteria	E	Lysine exporter protein LysE YggA	-	-	-	ko:K05834	-	-	-	-	ko00000,ko02000	2.A.76.1.1	-	-	LysE
HKD3_k127_4213603_0	887898.HMPREF0551_1391	0.0	1305.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1K21B@119060|Burkholderiaceae	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD3_k127_4213603_13	1218084.BBJK01000185_gene8012	1.353e-38	166.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria,1K761@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna polymerase III (Chi subunit)	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HKD3_k127_4213603_1	1144319.PMI16_04314	4.969e-186	595.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,4723W@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD3_k127_4213603_6	1095769.CAHF01000011_gene2664	6.656e-106	356.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,472Z1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Predicted permease YjgP/YjgQ family	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD3_k127_4213603_4	887898.HMPREF0551_1386	9.183e-116	403.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,1K1M1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Permease, YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD3_k127_4213603_5	1218075.BAYA01000006_gene2227	6.656e-109	362.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,1K3ZB@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4213603_9	1157708.KB907451_gene4947	7.172e-76	260.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2VNZN@28216|Betaproteobacteria,4AATF@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD3_k127_4213603_2	1206731.BAGB01000041_gene8693	1.705e-184	591.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FTYX@85025|Nocardiaceae	201174|Actinobacteria	IQ	Acyl-CoA synthetase	fadD8	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_4213603_7	1095769.CAHF01000011_gene2648	3.373e-97	327.0	COG0657@1|root,COG0657@2|Bacteria,1MV3J@1224|Proteobacteria,2VNRV@28216|Betaproteobacteria	28216|Betaproteobacteria	I	esterase	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3,COesterase
HKD3_k127_428036_24	1144319.PMI16_03127	8.266e-60	207.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,47267@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_428036_25	1158292.JPOE01000005_gene1195	5.489e-56	204.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2VR5Y@28216|Betaproteobacteria,1KKV6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0093)	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
HKD3_k127_428036_23	1095769.CAHF01000013_gene3368	2.753e-61	217.0	COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2VKX5@28216|Betaproteobacteria,4732R@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_428036_13	887898.HMPREF0551_0315	1.699e-119	396.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,1K0NW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the methyltransferase superfamily	rlmL	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
HKD3_k127_428036_28	1380367.JIBC01000012_gene2798	3.08e-27	116.0	COG4315@1|root,COG4315@2|Bacteria,1MZC6@1224|Proteobacteria,2UCKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Secreted repeat of	MA20_31645	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HKD3_k127_428036_4	1095769.CAHF01000001_gene3488	1.238e-188	595.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,472DJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type II/IV secretion system protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD3_k127_428036_3	887898.HMPREF0551_0308	2.989e-198	626.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,1K3Q4@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	twitching motility protein	pilT	-	-	ko:K02669,ko:K12203	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2,3.A.7.10.1,3.A.7.9.1	-	-	T2SSE
HKD3_k127_428036_19	93220.LV28_09400	7.249e-85	287.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,1JZTS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD3_k127_428036_18	765914.ThisiDRAFT_1965	1.773e-94	323.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,1S4JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	fumarate reductase respiratory complex transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD3_k127_428036_1	742823.HMPREF9465_00300	0.0	1025.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,4PQQW@995019|Sutterellaceae	28216|Betaproteobacteria	C	Fumarate reductase flavoprotein C-term	frdA	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD3_k127_428036_11	1203554.HMPREF1476_01834	2.28e-127	411.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,4PQCI@995019|Sutterellaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD3_k127_428036_15	864051.BurJ1DRAFT_1684	9.257e-112	377.0	COG1541@1|root,COG1541@2|Bacteria,1P22K@1224|Proteobacteria,2WGC2@28216|Betaproteobacteria,1KK0P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD3_k127_428036_8	1411123.JQNH01000001_gene914	4.578e-146	471.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD3_k127_428036_22	1122603.ATVI01000008_gene2213	2.967e-66	235.0	COG1305@1|root,COG1305@2|Bacteria,1R9XR@1224|Proteobacteria,1S4S3@1236|Gammaproteobacteria,1X66X@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD3_k127_428036_9	1123392.AQWL01000010_gene2312	3.083e-143	466.0	COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,2WGR7@28216|Betaproteobacteria,1KSBE@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_428036_0	395019.Bmul_0221	0.0	1624.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae	28216|Betaproteobacteria	C	oxidoreductase	porG	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HKD3_k127_428036_20	375286.mma_0605	5.219e-84	301.0	COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VIII@28216|Betaproteobacteria,4736S@75682|Oxalobacteraceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_428036_14	748247.AZKH_4234	2.981e-113	382.0	COG0284@1|root,COG0284@2|Bacteria,1MWH5@1224|Proteobacteria,2VHAB@28216|Betaproteobacteria,2KUGT@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD3_k127_428036_17	864073.HFRIS_003068	6.828e-106	347.0	COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,4729T@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	Transcriptional regulatory protein, C terminal	basR_3	-	-	ko:K02483,ko:K07666,ko:K07774	ko02020,ko02024,map02020,map02024	M00453,M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_428036_10	264198.Reut_A0525	7.546e-143	471.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,1K48Q@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HKD3_k127_428036_29	1123504.JQKD01000033_gene5263	1.169e-12	75.0	2EEJ7@1|root,338D7@2|Bacteria,1NCQP@1224|Proteobacteria,2VWTW@28216|Betaproteobacteria,4AFS6@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_428036_2	795666.MW7_2324	3.082e-222	702.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2VHQM@28216|Betaproteobacteria,1K092@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD3_k127_428036_21	887898.HMPREF0551_0175	2.644e-81	289.0	COG0457@1|root,COG0457@2|Bacteria,1P464@1224|Proteobacteria,2VMYZ@28216|Betaproteobacteria,1KE70@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF560)	-	-	-	-	-	-	-	-	-	-	-	-	DUF560,TPR_19
HKD3_k127_428036_27	1000565.METUNv1_02142	5.905e-29	136.0	COG4254@1|root,COG4254@2|Bacteria,1PGBS@1224|Proteobacteria,2VQEE@28216|Betaproteobacteria,2M02Z@206389|Rhodocyclales	206389|Rhodocyclales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD3_k127_428036_7	267608.RSc0530	2.312e-146	469.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2VH9V@28216|Betaproteobacteria,1K00G@119060|Burkholderiaceae	28216|Betaproteobacteria	T	PFAM PhoH family protein	ybeZ	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD3_k127_428036_26	887898.HMPREF0551_0171	3.157e-37	148.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2VSHV@28216|Betaproteobacteria,1K583@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD3_k127_428036_16	757424.Hsero_0719	1.96e-110	367.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,4727R@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Mg2 and Co2 transporter	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
HKD3_k127_428036_12	1366050.N234_02540	1.698e-119	404.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,1K0YM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD3_k127_428036_5	887898.HMPREF0551_0153	9.072e-172	541.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,1K1XK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HKD3_k127_428036_6	76114.ebA1330	1.274e-159	519.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,2KUWE@206389|Rhodocyclales	206389|Rhodocyclales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD3_k127_4308454_1	1100720.ALKN01000045_gene229	6.809e-218	680.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AAW5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD3_k127_4308454_10	316057.RPD_2025	3.122e-45	169.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_15120	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD3_k127_4308454_2	1000565.METUNv1_02039	3.094e-166	530.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VK0Q@28216|Betaproteobacteria,2KXJ0@206389|Rhodocyclales	206389|Rhodocyclales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD3_k127_4308454_0	1131813.AQVT01000001_gene3977	1.595e-235	740.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,1JR1I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
HKD3_k127_4308454_7	580332.Slit_2684	1.67e-68	237.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2VRIB@28216|Betaproteobacteria,44VRP@713636|Nitrosomonadales	28216|Betaproteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD3_k127_4308454_11	768671.ThimaDRAFT_1415	1.345e-11	69.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales	135613|Chromatiales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD3_k127_4308454_3	414684.RC1_0637	6.354e-149	502.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2JPUZ@204441|Rhodospirillales	204441|Rhodospirillales	CO	Thiol disulfide interchange protein	dsbD	-	1.8.1.8	ko:K04084,ko:K08344	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.5	-	-	DsbC,DsbD,Thioredoxin_7
HKD3_k127_4308454_8	1249627.D779_2178	9.726e-57	226.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,1S3TJ@1236|Gammaproteobacteria,1WXYE@135613|Chromatiales	135613|Chromatiales	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD3_k127_4308454_5	999541.bgla_1g31480	7.354e-97	343.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2VH64@28216|Betaproteobacteria,1K0NI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD3_k127_4308454_9	626418.bglu_1g28160	2.236e-51	195.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1K1P1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Periplasmic binding protein	btuF	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
HKD3_k127_4308454_6	1217718.ALOU01000029_gene782	1.412e-74	262.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,1K1SH@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HKD3_k127_4308454_4	243365.CV_2697	6.62e-133	447.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,2VJRT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD3_k127_4326754_6	864051.BurJ1DRAFT_4203	1.837e-11	64.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,1KJ38@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD3_k127_4326754_1	883126.HMPREF9710_03249	3.942e-79	272.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,473BA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Involved in biogenesis of respiratory and photosynthetic systems	senC	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD3_k127_4326754_4	62928.azo0966	2.543e-32	136.0	COG2703@1|root,COG2703@2|Bacteria,1N5KC@1224|Proteobacteria,2VV3W@28216|Betaproteobacteria,2KZU0@206389|Rhodocyclales	206389|Rhodocyclales	P	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_4326754_2	420662.Mpe_A3564	1.973e-78	274.0	COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria,1KK13@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_4326754_5	987059.RBXJA2T_03773	5.242e-29	120.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,1KMFU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CbiX	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD3_k127_4326754_0	795666.MW7_0328	1.127e-121	400.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,1K0Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	K	RNA polymerase sigma factor RpoH	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD3_k127_4326754_3	748247.AZKH_4359	8.628e-76	260.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,2KYH3@206389|Rhodocyclales	206389|Rhodocyclales	O	maleylacetoacetate isomerase	-	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_N_3
HKD3_k127_4480454_4	1121918.ARWE01000001_gene2240	6.879e-53	189.0	COG1359@1|root,COG1359@2|Bacteria,1N2BB@1224|Proteobacteria,42ZU2@68525|delta/epsilon subdivisions,2WVEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4480454_3	1232410.KI421426_gene1459	2.39e-124	413.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42PGM@68525|delta/epsilon subdivisions,2X5J8@28221|Deltaproteobacteria,43SW4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_4480454_0	1232410.KI421426_gene1458	0.0	1218.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_4480454_1	1121127.JAFA01000002_gene1556	2.059e-178	572.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KCHF@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD3_k127_4480454_2	887898.HMPREF0551_1131	1.083e-168	550.0	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,1JZWT@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Lytic transglycosylase	mltD	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD3_k127_4480454_5	935567.JAES01000015_gene2782	5.288e-14	72.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,1X4E0@135614|Xanthomonadales	135614|Xanthomonadales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD3_k127_4801192_10	342113.DM82_184	3.41e-108	359.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1K2BX@119060|Burkholderiaceae	28216|Betaproteobacteria	M	heptosyltransferase II	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD3_k127_4801192_18	204773.HEAR2612	9.932e-22	108.0	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,474ZA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HKD3_k127_4801192_8	1095769.CAHF01000013_gene3320	1.484e-168	533.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,47362@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD3_k127_4801192_12	1123504.JQKD01000006_gene1576	1.275e-102	347.0	COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2VKPZ@28216|Betaproteobacteria,4AB3E@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_4801192_1	887898.HMPREF0551_1684	2.13e-263	839.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,1K1WC@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD3_k127_4801192_5	640081.Dsui_3403	7.624e-206	689.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria,2KUGH@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971,DUF748
HKD3_k127_4801192_11	388051.AUFE01000014_gene6009	1.837e-105	377.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,1K2WY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	opaA	-	3.5.5.1	ko:K01501,ko:K11206	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD3_k127_4801192_2	375286.mma_0837	3.011e-245	764.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,472S0@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD3_k127_4801192_4	56780.SYN_01931	6.449e-208	693.0	COG2885@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,42M50@68525|delta/epsilon subdivisions,2WIP4@28221|Deltaproteobacteria,2MQYM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD3_k127_4801192_7	1095769.CAHF01000011_gene2699	8.587e-183	577.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,4727C@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroG	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD3_k127_4801192_16	887898.HMPREF0551_1669	1.393e-45	186.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,2VX3A@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD3_k127_4801192_17	1523503.JPMY01000002_gene3913	2.041e-37	155.0	COG1917@1|root,COG1917@2|Bacteria,1N7QJ@1224|Proteobacteria,1SBAC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2
HKD3_k127_4801192_14	760117.JN27_10805	2.947e-76	266.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,47268@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Cobalamin adenosyltransferase	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD3_k127_4801192_3	266264.Rmet_2924	2.249e-212	676.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,1K241@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	dld	-	1.1.2.4,1.1.5.12	ko:K00102,ko:K03777	ko00620,ko01120,map00620,map01120	-	R00197,R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_4801192_13	1123504.JQKD01000005_gene4716	1.419e-87	317.0	COG0671@1|root,COG0671@2|Bacteria,1PM2D@1224|Proteobacteria,2VXHW@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD3_k127_4801192_6	1122604.JONR01000037_gene4264	2.488e-185	593.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X60A@135614|Xanthomonadales	135614|Xanthomonadales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_4801192_15	1121920.AUAU01000010_gene61	8.731e-68	239.0	COG0500@1|root,COG2226@2|Bacteria,3Y5HG@57723|Acidobacteria	57723|Acidobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_4801192_9	887898.HMPREF0551_1644	1.542e-151	487.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,1K21G@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD3_k127_4801192_0	251221.35210806	1.218e-293	916.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD3_k127_4875221_1	452637.Oter_1466	1.957e-291	904.0	COG0243@1|root,COG0243@2|Bacteria,46U1H@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_4875221_9	452637.Oter_1465	1.022e-97	321.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nrfC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809	-	ko:K04014,ko:K08353,ko:K08358,ko:K16293	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
HKD3_k127_4875221_11	452637.Oter_1464	9.925e-94	318.0	COG3301@1|root,COG3301@2|Bacteria	2|Bacteria	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD,NrfD_2
HKD3_k127_4875221_5	1121920.AUAU01000025_gene2340	5.083e-128	425.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD3_k127_4875221_16	1191523.MROS_1777	3.041e-54	195.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD3_k127_4875221_15	452637.Oter_1462	5.489e-56	204.0	COG0607@1|root,COG2391@1|root,COG0607@2|Bacteria,COG2391@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.1,2.8.1.2	ko:K00406,ko:K01011,ko:K07112	ko00190,ko00270,ko00920,ko01100,ko01120,ko02020,ko04122,map00190,map00270,map00920,map01100,map01120,map02020,map04122	M00156	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	PALP,Rhodanese,Sulf_transp
HKD3_k127_4875221_3	1283300.ATXB01000001_gene2143	4.91e-132	444.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
HKD3_k127_4875221_18	395965.Msil_2570	5.901e-26	112.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,3NBRQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	bigR	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD3_k127_4875221_4	522306.CAP2UW1_3793	1.737e-128	417.0	COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,2VI6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acyl-transferase	yihG	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD3_k127_4875221_17	75379.Tint_1863	2.04e-47	183.0	2D596@1|root,32TII@2|Bacteria,1N3RK@1224|Proteobacteria,2VVE7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4875221_7	1123368.AUIS01000019_gene1225	2.006e-102	355.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,2NDP9@225057|Acidithiobacillales	225057|Acidithiobacillales	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_4875221_2	375286.mma_0528	5.183e-170	546.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,4725T@75682|Oxalobacteraceae	28216|Betaproteobacteria	JKL	Belongs to the DEAD box helicase family	rhlE2	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD3_k127_4875221_8	477184.KYC_00480	2.675e-102	353.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,3T2AB@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HKD3_k127_4875221_10	266264.Rmet_2580	2.988e-97	331.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,2VJTZ@28216|Betaproteobacteria,1K0MA@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4875221_6	1366050.N234_15340	2.275e-106	353.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2VHPA@28216|Betaproteobacteria,1K0N7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the pirin family	yhhW_2	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HKD3_k127_4875221_14	1169143.KB911048_gene5368	2.957e-62	220.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VK49@28216|Betaproteobacteria,1K090@119060|Burkholderiaceae	28216|Betaproteobacteria	S	flavodoxin nitric oxide synthase	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD3_k127_4875221_13	670292.JH26_23105	2.374e-62	238.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD3_k127_4875221_12	1123487.KB892834_gene2639	2.062e-73	259.0	COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2VJS5@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_4875221_0	887898.HMPREF0551_1491	0.0	1353.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD3_k127_4875221_19	864051.BurJ1DRAFT_0172	4.452e-08	57.0	2CIC8@1|root,33JK4@2|Bacteria,1NH5Z@1224|Proteobacteria,2VYDU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4875221_20	1384054.N790_06420	5.439e-07	53.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1X587@135614|Xanthomonadales	135614|Xanthomonadales	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
HKD3_k127_4878517_16	887898.HMPREF0551_0747	8.842e-89	303.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,1K0BK@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_4878517_22	887898.HMPREF0551_0748	2.457e-73	261.0	COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,1K1ID@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_4878517_26	243365.CV_2979	1.605e-69	249.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,2KQEW@206351|Neisseriales	206351|Neisseriales	I	squalene synthase HpnC	hpnC	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
HKD3_k127_4878517_12	1000565.METUNv1_00666	5.216e-113	385.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,2KUHC@206389|Rhodocyclales	206389|Rhodocyclales	I	Squalene synthase HpnD	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD3_k127_4878517_23	62928.azo1885	2.721e-70	264.0	COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,2KVAB@206389|Rhodocyclales	206389|Rhodocyclales	H	squalene-associated FAD-dependent desaturase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD3_k127_4878517_6	1235457.C404_09535	2.294e-213	671.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1K1ZE@119060|Burkholderiaceae	28216|Betaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD3_k127_4878517_10	757424.Hsero_2150	1.028e-131	428.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria,473IG@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD3_k127_4878517_9	204773.HEAR1760	4.617e-191	604.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,473WZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	lplT	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_4878517_19	1366050.N234_11775	4.689e-80	276.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,1K1QM@119060|Burkholderiaceae	28216|Betaproteobacteria	L	TIGRFAM phage SPO1 DNA polymerase-related protein	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_4878517_30	265072.Mfla_0413	2.037e-35	154.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2VUIW@28216|Betaproteobacteria,2KMVP@206350|Nitrosomonadales	206350|Nitrosomonadales	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD3_k127_4878517_29	123899.JPQP01000002_gene1098	7.071e-36	146.0	COG0454@1|root,COG1214@1|root,COG0456@2|Bacteria,COG1214@2|Bacteria,1RIE6@1224|Proteobacteria,2VUIW@28216|Betaproteobacteria,3T2RU@506|Alcaligenaceae	28216|Betaproteobacteria	KO	Acetyltransferase	rimI	-	2.3.1.128	ko:K03789,ko:K14742	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HKD3_k127_4878517_13	887898.HMPREF0551_0758	3.437e-110	361.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI6B@28216|Betaproteobacteria,1K08B@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	ompR	-	-	ko:K02483,ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_4878517_14	887898.HMPREF0551_0759	3.409e-100	352.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,1K298@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	risS	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,RisS_PPD
HKD3_k127_4878517_24	1121878.AUGL01000014_gene1630	3.417e-70	240.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD3_k127_4878517_8	1266925.JHVX01000009_gene53	9.344e-204	647.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3501
HKD3_k127_4878517_21	1288494.EBAPG3_16120	1.047e-73	252.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VQUX@28216|Betaproteobacteria,372TE@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HKD3_k127_4878517_28	395965.Msil_2746	1.208e-39	160.0	COG0745@1|root,COG0745@2|Bacteria,1NWP7@1224|Proteobacteria,2USQ2@28211|Alphaproteobacteria,3NCGG@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD3_k127_4878517_31	876269.ARWA01000001_gene1529	3.517e-32	145.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,2UJ8E@28211|Alphaproteobacteria,3NCCE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4878517_4	395965.Msil_2748	2.236e-222	709.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2TYKR@28211|Alphaproteobacteria,3NBHZ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
HKD3_k127_4878517_18	395965.Msil_2749	2.557e-82	280.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria,3NBT8@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
HKD3_k127_4878517_15	876269.ARWA01000001_gene1526	1.55e-97	331.0	COG3383@1|root,COG3383@2|Bacteria,1MXTC@1224|Proteobacteria,2U6Y9@28211|Alphaproteobacteria,3NC3R@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	4Fe-4S single cluster domain	-	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
HKD3_k127_4878517_2	876269.ARWA01000001_gene1525	3.36e-242	764.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,3NC06@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.12.1.2,1.6.5.3	ko:K00335,ko:K18005	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_4878517_32	1286631.X805_19740	5.656e-22	102.0	COG2388@1|root,COG2388@2|Bacteria,1N8AQ@1224|Proteobacteria,2VW02@28216|Betaproteobacteria,1KMIR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
HKD3_k127_4878517_1	1223521.BBJX01000002_gene2753	8.071e-260	805.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,4ACES@80864|Comamonadaceae	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_4878517_25	388051.AUFE01000055_gene308	1.471e-69	240.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,1K0T3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD3_k127_4878517_27	1349767.GJA_3329	3.416e-58	209.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,472XA@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD3_k127_4878517_0	1163408.UU9_06959	0.0	1057.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1X4J8@135614|Xanthomonadales	135614|Xanthomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD3_k127_4878517_20	991905.SL003B_2977	4.811e-75	267.0	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2U1KC@28211|Alphaproteobacteria,4BR4Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_4
HKD3_k127_4878517_5	1211114.ALIP01000008_gene2583	1.403e-213	671.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1X3FT@135614|Xanthomonadales	135614|Xanthomonadales	E	O-acetylhomoserine	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_4878517_33	1100720.ALKN01000045_gene331	8.23e-20	106.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_7
HKD3_k127_4878517_11	1157708.KB907460_gene1359	4.639e-130	425.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,4AC1Z@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Methyltransferase type 11	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_4878517_3	1454202.PPBDW_90180___1	2.779e-240	759.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales	135623|Vibrionales	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD3_k127_4878517_34	1380355.JNIJ01000004_gene2775	4.07e-17	87.0	COG4875@1|root,COG4875@2|Bacteria,1RD75@1224|Proteobacteria,2UEDN@28211|Alphaproteobacteria,3JYZZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcium/calmodulin dependent protein kinase II association domain	-	-	-	-	-	-	-	-	-	-	-	-	CaMKII_AD,DUF4440
HKD3_k127_4878517_17	44056.XP_009033066.1	1.506e-84	290.0	2CY02@1|root,2S119@2759|Eukaryota	2759|Eukaryota	S	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD3_k127_4878517_7	75379.Tint_1319	3.359e-210	663.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,1KK6U@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD3_k127_4878517_35	93220.LV28_03870	7.944e-10	60.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2VJ2N@28216|Betaproteobacteria,1K319@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyhydroxyalkanoate synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD3_k127_4915491_15	29581.BW37_04320	1.143e-08	59.0	COG1280@1|root,COG1280@2|Bacteria,1REQG@1224|Proteobacteria,2VR5M@28216|Betaproteobacteria,477Y8@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD3_k127_4915491_4	339670.Bamb_6058	5.25e-85	291.0	COG0697@1|root,COG0697@2|Bacteria,1RATE@1224|Proteobacteria,2W99N@28216|Betaproteobacteria,1KA2Z@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_4915491_8	84531.JMTZ01000015_gene2621	4.078e-60	218.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RP7Q@1236|Gammaproteobacteria,1X62S@135614|Xanthomonadales	135614|Xanthomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4915491_6	1173027.Mic7113_1073	1.838e-68	248.0	COG0366@1|root,COG0366@2|Bacteria,1G53D@1117|Cyanobacteria,1HHMX@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Alpha amylase, catalytic domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
HKD3_k127_4915491_0	420662.Mpe_A1940	1.512e-159	512.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1KJ43@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_4915491_13	1217658.F987_02539	3.368e-17	89.0	COG1846@1|root,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria,1RNX4@1236|Gammaproteobacteria,3NMVM@468|Moraxellaceae	1236|Gammaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR,MarR_2
HKD3_k127_4915491_5	926560.KE387023_gene3595	8.128e-73	277.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,1WMBC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,BTAD,TPR_12
HKD3_k127_4915491_7	1157708.KB907450_gene5251	2.668e-68	243.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	-	-	2.1.1.156,2.1.1.265	ko:K16868,ko:K18896	ko00260,map00260	-	R10060	RC00003,RC03038	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD3_k127_4915491_1	1255043.TVNIR_2998	4.011e-143	467.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1X2E9@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HKD3_k127_4915491_2	1218084.BBJK01000001_gene65	3.285e-118	389.0	COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,2W0DZ@28216|Betaproteobacteria,1KCSK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	S-methyl_trans
HKD3_k127_4915491_3	1496688.ER33_11240	7.91e-94	319.0	COG3000@1|root,COG3000@2|Bacteria,1G441@1117|Cyanobacteria,22T78@167375|Cyanobium	1117|Cyanobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD3_k127_4915491_9	864073.HFRIS_000325	3.246e-59	228.0	COG0625@1|root,COG0625@2|Bacteria,1NX28@1224|Proteobacteria,2VQ5Y@28216|Betaproteobacteria,4772Y@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	yfcF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_4,GST_N,GST_N_3
HKD3_k127_4915491_10	243365.CV_2795	7.522e-35	153.0	COG0346@1|root,COG0346@2|Bacteria,1RCX8@1224|Proteobacteria	1224|Proteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_4915491_11	1124983.PFLCHA0_c34740	1.331e-34	145.0	COG1171@1|root,COG1171@2|Bacteria,1RA37@1224|Proteobacteria,1RXSG@1236|Gammaproteobacteria,1YTYB@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_4915491_12	215803.DB30_7768	1.4e-26	117.0	COG1670@1|root,COG1670@2|Bacteria,1RD77@1224|Proteobacteria,4351D@68525|delta/epsilon subdivisions,2X948@28221|Deltaproteobacteria,2Z1TW@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_4915491_14	864051.BurJ1DRAFT_3693	3.514e-15	76.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,1KJVT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD3_k127_4915607_17	887898.HMPREF0551_2208	2.634e-63	238.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2VMPA@28216|Betaproteobacteria,1K20E@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
HKD3_k127_4915607_5	887898.HMPREF0551_2207	9.131e-193	612.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,1K0H9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD3_k127_4915607_7	62928.azo3782	2.775e-173	565.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,2KUBD@206389|Rhodocyclales	206389|Rhodocyclales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD3_k127_4915607_28	1304883.KI912532_gene956	1.823e-28	119.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,2KWVF@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphotransferase System	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD3_k127_4915607_24	887898.HMPREF0551_2204	7.821e-36	140.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,1K5AR@119060|Burkholderiaceae	28216|Betaproteobacteria	G	pts system fructose subfamily IIa component	manX	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
HKD3_k127_4915607_8	887898.HMPREF0551_2203	8.831e-121	399.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1K2PI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HKD3_k127_4915607_3	1095769.CAHF01000014_gene3107	7.911e-223	700.0	COG0342@1|root,COG0342@2|Bacteria,1MVFS@1224|Proteobacteria,2VHD9@28216|Betaproteobacteria,472WZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Glutamate-cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GshA
HKD3_k127_4915607_4	1095769.CAHF01000014_gene3108	5.805e-217	687.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,4724A@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Ammonium Transporter Family	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD3_k127_4915607_18	365046.Rta_01440	1.437e-60	211.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,4AE4W@80864|Comamonadaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD3_k127_4915607_14	1216976.AX27061_1232	1.334e-68	246.0	2DNWG@1|root,32ZIW@2|Bacteria,1RFKX@1224|Proteobacteria,2VRRE@28216|Betaproteobacteria,3T53P@506|Alcaligenaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HKD3_k127_4915607_30	93220.LV28_16715	1.04e-13	76.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,2VVR4@28216|Betaproteobacteria,1K9GB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Membrane fusogenic activity	yqiC	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HKD3_k127_4915607_1	472759.Nhal_0770	3.649e-305	948.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD3_k127_4915607_22	1123392.AQWL01000007_gene1011	1.485e-44	175.0	COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,2VRQB@28216|Betaproteobacteria,1KSJT@119069|Hydrogenophilales	119069|Hydrogenophilales	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4915607_23	243233.MCA0583	3.175e-36	144.0	COG0517@1|root,COG0517@2|Bacteria,1QJRF@1224|Proteobacteria,1THSQ@1236|Gammaproteobacteria,1XFJQ@135618|Methylococcales	135618|Methylococcales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_4915607_0	614083.AWQR01000030_gene2824	0.0	1060.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_4915607_12	1005048.CFU_0213	2.596e-94	317.0	COG1396@1|root,COG1396@2|Bacteria,1MWUC@1224|Proteobacteria,2VHIE@28216|Betaproteobacteria,473MS@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD3_k127_4915607_27	1159870.KB907784_gene1487	2.164e-29	132.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,3T4JJ@506|Alcaligenaceae	28216|Betaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD3_k127_4915607_10	1188256.BASI01000001_gene587	3.493e-116	390.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria,3FDJG@34008|Rhodovulum	28211|Alphaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD3_k127_4915607_25	580332.Slit_1694	1.964e-31	133.0	COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2VV8B@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
HKD3_k127_4915607_15	864051.BurJ1DRAFT_1621	6.376e-65	228.0	COG0406@1|root,COG0406@2|Bacteria,1N83T@1224|Proteobacteria,2VY3M@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PFAM Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD3_k127_4915607_16	365046.Rta_07460	1.27e-63	251.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VIST@28216|Betaproteobacteria,4AARE@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4915607_6	883078.HMPREF9695_02646	1.149e-182	594.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,3JWAE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_4915607_9	983917.RGE_13960	4.519e-120	402.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2VHP3@28216|Betaproteobacteria,1KKA2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_4915607_21	1100720.ALKN01000040_gene2208	9.007e-53	188.0	2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2VXF8@28216|Betaproteobacteria,4AJK8@80864|Comamonadaceae	28216|Betaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HKD3_k127_4915607_26	748247.AZKH_2710	3.079e-30	122.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,2VW0Y@28216|Betaproteobacteria	28216|Betaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
HKD3_k127_4915607_20	1123261.AXDW01000023_gene3570	1.679e-53	203.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1S758@1236|Gammaproteobacteria,1XCHN@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_4915607_13	296591.Bpro_2748	3.002e-74	256.0	COG0500@1|root,COG2226@2|Bacteria,1MZVH@1224|Proteobacteria,2VZ2M@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD3_k127_4915607_2	365044.Pnap_3557	1.187e-223	698.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria,4AE79@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD3_k127_4915607_11	983917.RGE_07310	5.684e-107	353.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2VPNT@28216|Betaproteobacteria,1KNTZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
HKD3_k127_4915607_19	1163617.SCD_n01991	2.982e-60	218.0	28PU4@1|root,2ZCF6@2|Bacteria,1RBK2@1224|Proteobacteria,2VQ65@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4915607_29	580332.Slit_2773	1.299e-14	86.0	COG2345@1|root,COG2345@2|Bacteria,1N9W3@1224|Proteobacteria,2VWG0@28216|Betaproteobacteria,44WNR@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4917907_65	1125863.JAFN01000001_gene485	8.722e-21	100.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Major facilitator superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HKD3_k127_4917907_33	1207063.P24_11215	5.223e-96	333.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,2TUZ8@28211|Alphaproteobacteria,2JS0R@204441|Rhodospirillales	204441|Rhodospirillales	I	COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_4917907_35	1402135.SUH3_09535	8.673e-87	296.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2TVMU@28211|Alphaproteobacteria,3ZYY4@60136|Sulfitobacter	28211|Alphaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_4917907_15	1000565.METUNv1_00696	3.071e-186	590.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,2KUZF@206389|Rhodocyclales	206389|Rhodocyclales	E	Aminotransferase	tyrB	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_4917907_0	1366050.N234_05420	0.0	1109.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,1K3H7@119060|Burkholderiaceae	28216|Betaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD3_k127_4917907_38	887898.HMPREF0551_0834	1.431e-74	256.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,1K57G@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	ptpA	GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD3_k127_4917907_5	522306.CAP2UW1_1893	4.041e-300	932.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,1KR3Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Malonate decarboxylase, alpha subunit, transporter	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_4917907_37	887898.HMPREF0551_0833	6.887e-80	269.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,1K2IF@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Iron-sulfur cluster assembly transcription factor	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HKD3_k127_4917907_11	342113.DM82_1893	2.028e-223	696.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1K14U@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD3_k127_4917907_39	1123368.AUIS01000004_gene253	6.264e-74	251.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,2NCUC@225057|Acidithiobacillales	225057|Acidithiobacillales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD3_k127_4917907_46	93220.LV28_23390	1.09e-53	192.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,1K7RI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the HesB IscA family	iscA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD3_k127_4917907_49	883126.HMPREF9710_02182	1.603e-49	183.0	COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,4744T@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
HKD3_k127_4917907_8	762376.AXYL_03959	1.169e-258	815.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,3T1C3@506|Alcaligenaceae	28216|Betaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
HKD3_k127_4917907_55	637389.Acaty_c0815	2.657e-42	177.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,2NCYH@225057|Acidithiobacillales	225057|Acidithiobacillales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD3_k127_4917907_62	1070319.CAGGBEG34_200053	2.042e-26	119.0	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,2VVQU@28216|Betaproteobacteria,1K9HY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Fe-S assembly protein IscX	iscX	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
HKD3_k127_4917907_31	1158165.KB898872_gene929	4.338e-108	358.0	COG3329@1|root,COG3329@2|Bacteria,1N85P@1224|Proteobacteria,1RRX7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	permease	-	-	-	ko:K07086	-	-	-	-	ko00000	-	-	-	Sbt_1
HKD3_k127_4917907_61	1265502.KB905947_gene1070	3.786e-27	121.0	COG0347@1|root,COG0347@2|Bacteria,1MZ43@1224|Proteobacteria,2VWAG@28216|Betaproteobacteria	28216|Betaproteobacteria	E	nitrogen regulatory protein P-II	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4917907_41	1502852.FG94_01297	6.877e-68	254.0	COG2807@1|root,COG2807@2|Bacteria,1QUCZ@1224|Proteobacteria,2WHKR@28216|Betaproteobacteria,473R1@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_4917907_53	236097.ADG881_61	4.49e-45	170.0	COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,1S5RX@1236|Gammaproteobacteria,1XM8N@135619|Oceanospirillales	135619|Oceanospirillales	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD3_k127_4917907_9	626418.bglu_1g24620	7.624e-245	765.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,1K1TR@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD3_k127_4917907_17	339670.Bamb_2154	6.603e-179	565.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,1JZTD@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD3_k127_4917907_14	882378.RBRH_03836	2.928e-200	644.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,1K24G@119060|Burkholderiaceae	28216|Betaproteobacteria	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD3_k127_4917907_59	1192124.LIG30_0241	5.259e-37	153.0	COG4255@1|root,COG4255@2|Bacteria,1R59K@1224|Proteobacteria,2VKW9@28216|Betaproteobacteria,1K0S6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PhosphMutase
HKD3_k127_4917907_22	757424.Hsero_2778	6.266e-161	527.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,473AI@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	MacB-like periplasmic core domain	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD3_k127_4917907_36	204773.HEAR2223	1.647e-80	290.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,472IU@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD3_k127_4917907_34	93220.LV28_23490	4.728e-88	312.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,2VH67@28216|Betaproteobacteria,1JZQE@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM TatD-related deoxyribonuclease	yjjV	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD3_k127_4917907_18	1502852.FG94_04138	1.254e-175	580.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,4737H@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Competence protein	comA	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD3_k127_4917907_30	414684.RC1_1846	1.449e-115	377.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,2JQYQ@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HKD3_k127_4917907_32	426114.THI_1695	6.336e-101	336.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,1KJPN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM alpha beta hydrolase fold	phaY2	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD3_k127_4917907_57	1198452.Jab_2c12450	7.61e-38	163.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2VU19@28216|Betaproteobacteria,474J3@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_4917907_24	375286.mma_2249	2.785e-151	488.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,472U4@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type Fe3 transport system, periplasmic component	fbpA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HKD3_k127_4917907_23	1123392.AQWL01000002_gene1815	1.771e-156	516.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,1KRM3@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HKD3_k127_4917907_58	1123399.AQVE01000001_gene754	1.048e-37	145.0	COG3162@1|root,COG3162@2|Bacteria,1N9T2@1224|Proteobacteria,1SSS2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
HKD3_k127_4917907_7	1122951.ATUE01000009_gene418	1.412e-267	843.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,3NJC9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD3_k127_4917907_67	1348657.M622_01260	3.478e-07	55.0	2DNR5@1|root,32YQH@2|Bacteria,1NBXJ@1224|Proteobacteria,2VW7K@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4917907_3	1318628.MARLIPOL_05415	0.0	1056.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,46A0J@72275|Alteromonadaceae	1236|Gammaproteobacteria	ET	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HKD3_k127_4917907_52	159087.Daro_1632	1.457e-45	179.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,2VT7U@28216|Betaproteobacteria,2KWBT@206389|Rhodocyclales	206389|Rhodocyclales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD3_k127_4917907_13	62928.azo2410	4.009e-207	668.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_4917907_50	795666.MW7_3428	1.899e-49	188.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,2VSHN@28216|Betaproteobacteria,1KHTP@119060|Burkholderiaceae	28216|Betaproteobacteria	M	NlpC/P60 family	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
HKD3_k127_4917907_4	1123487.KB892835_gene3380	0.0	1049.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,2KV9F@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD3_k127_4917907_25	1095769.CAHF01000009_gene1397	1.564e-148	476.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
HKD3_k127_4917907_54	1304883.KI912532_gene299	8.24e-43	167.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,2KWND@206389|Rhodocyclales	206389|Rhodocyclales	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD3_k127_4917907_45	1349767.GJA_3206	2.169e-60	224.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2VRBU@28216|Betaproteobacteria,474E6@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Haem-degrading	glcG	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
HKD3_k127_4917907_19	864051.BurJ1DRAFT_2984	6.2e-170	543.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,2VKNE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Major facilitator Superfamily	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HKD3_k127_4917907_51	1144319.PMI16_02204	2.893e-48	191.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2VK1G@28216|Betaproteobacteria,472ME@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33,6.3.4.15	ko:K01947,ko:K03525	ko00770,ko00780,ko01100,map00770,map00780,map01100	M00120	R01074,R02971,R03018,R04391,R05145	RC00002,RC00017,RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Pan_kinase
HKD3_k127_4917907_20	94624.Bpet4039	7.081e-164	531.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VNJ6@28216|Betaproteobacteria,3T6W6@506|Alcaligenaceae	28216|Betaproteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HKD3_k127_4917907_21	1394178.AWOO02000064_gene61	1.699e-163	528.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4EN0I@85012|Streptosporangiales	201174|Actinobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_4917907_16	864051.BurJ1DRAFT_4606	2.64e-185	594.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2VHY1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Extracellular solute-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_4917907_27	1231391.AMZF01000009_gene1749	1.521e-131	427.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VJJU@28216|Betaproteobacteria,3T8WN@506|Alcaligenaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD3_k127_4917907_29	269796.Rru_A0981	2.548e-122	402.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria,2JQ5D@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD3_k127_4917907_10	1205680.CAKO01000040_gene991	4.327e-232	746.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales	204441|Rhodospirillales	P	COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD3_k127_4917907_28	388051.AUFE01000020_gene4244	3.823e-125	418.0	COG3391@1|root,COG3391@2|Bacteria,1R8X0@1224|Proteobacteria,2VNTY@28216|Betaproteobacteria,1K4IG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM methylamine dehydrogenase heavy subunit	aauB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.4.9.1,1.4.9.2	ko:K13372,ko:K15229	ko00350,ko00360,ko00680,ko00950,ko01100,ko01110,ko01120,map00350,map00360,map00680,map00950,map01100,map01110,map01120	-	R00606,R02382,R02612,R04300	RC00062,RC00189	ko00000,ko00001,ko01000	-	-	-	Me-amine-dh_H
HKD3_k127_4917907_64	1286631.X805_24430	2.754e-23	116.0	2DNZS@1|root,32ZYX@2|Bacteria,1MZ8A@1224|Proteobacteria,2VWYY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	MauE
HKD3_k127_4917907_42	1286631.X805_24440	4.653e-65	238.0	COG0526@1|root,COG0526@2|Bacteria,1R3WA@1224|Proteobacteria,2VQKN@28216|Betaproteobacteria,1KKWF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Thioredoxin-like domain	mauD	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin_2
HKD3_k127_4917907_40	62928.azo2257	3.803e-72	248.0	28V8Y@1|root,2ZHBX@2|Bacteria,1RD5G@1224|Proteobacteria,2VS15@28216|Betaproteobacteria,2KYYG@206389|Rhodocyclales	206389|Rhodocyclales	C	Methylamine dehydrogenase, L chain	-	-	1.4.9.1	ko:K15228	ko00680,ko01120,map00680,map01120	-	R00606	RC00189	ko00000,ko00001,ko01000	-	-	-	Me-amine-dh_L
HKD3_k127_4917907_63	1286631.X805_24470	1.007e-23	111.0	COG2010@1|root,COG2010@2|Bacteria,1N8E4@1224|Proteobacteria,2VWFV@28216|Betaproteobacteria,1KMIJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4917907_12	266264.Rmet_5087	8.495e-219	687.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,1K48A@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HKD3_k127_4917907_6	1095769.CAHF01000008_gene3655	1.395e-296	915.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,472YG@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HKD3_k127_4917907_43	420662.Mpe_A1384	4.722e-64	225.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,1KK23@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	UPF0114 protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
HKD3_k127_4917907_1	1532557.JL37_08350	0.0	1079.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,3T32R@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD3_k127_4917907_44	1244869.H261_00465	4.452e-61	220.0	COG0457@1|root,COG0457@2|Bacteria	1244869.H261_00465|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4917907_56	1430440.MGMSRv2_2074	2.09e-38	145.0	COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4212
HKD3_k127_4917907_2	1244869.H261_00455	0.0	1058.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,2JQI9@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD3_k127_4917907_48	243160.BMA2813	4.592e-52	198.0	COG1835@1|root,COG1835@2|Bacteria,1RHUN@1224|Proteobacteria,2VSFY@28216|Betaproteobacteria,1KHTT@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD3_k127_4917907_47	580332.Slit_1215	1.131e-53	209.0	28PZA@1|root,2ZCIS@2|Bacteria,1RCMD@1224|Proteobacteria,2VYEF@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4917907_26	1223521.BBJX01000013_gene435	1.407e-131	428.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VJ15@28216|Betaproteobacteria,4ACTX@80864|Comamonadaceae	28216|Betaproteobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_4917907_66	887898.HMPREF0551_0646	1.131e-20	91.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,1K0F8@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD3_k127_4945821_3	1158292.JPOE01000005_gene1356	2.544e-35	134.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2VKSK@28216|Betaproteobacteria,1KK86@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_4945821_0	1286631.X805_40630	2.723e-298	918.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,1KJY5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HKD3_k127_4945821_1	395495.Lcho_3661	8.191e-237	737.0	COG0369@1|root,COG1145@1|root,COG0369@2|Bacteria,COG1145@2|Bacteria,1NCKQ@1224|Proteobacteria,2VIZE@28216|Betaproteobacteria,1KKD1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Oxidoreductase NAD-binding domain	boxA	-	1.14.13.208,1.18.1.2,1.19.1.1	ko:K00528,ko:K02641,ko:K15511	ko00195,ko00362,ko01100,map00195,map00362,map01100	-	R09555,R10159	RC01739	ko00000,ko00001,ko00194,ko01000	-	-	-	FAD_binding_6,Fer4,NAD_binding_1
HKD3_k127_4945821_2	264198.Reut_A0086	2.187e-83	278.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,1K389@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD3_k127_4960592_7	864073.HFRIS_008041	1.916e-73	268.0	COG1052@1|root,COG1052@2|Bacteria,1RAWT@1224|Proteobacteria,2VRZN@28216|Betaproteobacteria,478YR@75682|Oxalobacteraceae	28216|Betaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_4960592_4	1408418.JNJH01000005_gene2079	1.111e-96	332.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,2JQMS@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD3_k127_4960592_2	1144342.PMI40_00599	7.524e-127	419.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VME1@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_2
HKD3_k127_4960592_6	1054213.HMPREF9946_03959	7.666e-84	304.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2TTJV@28211|Alphaproteobacteria,2JPXD@204441|Rhodospirillales	204441|Rhodospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.215	ko:K22229	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01739	RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_4960592_9	204773.HEAR2783	1.637e-13	82.0	2B1HQ@1|root,31TYQ@2|Bacteria,1MYSE@1224|Proteobacteria,2VUU0@28216|Betaproteobacteria,478TP@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	CNP1-like family	-	-	-	-	-	-	-	-	-	-	-	-	CNP1
HKD3_k127_4960592_5	123899.JPQP01000019_gene2755	8.12e-85	306.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2VIDX@28216|Betaproteobacteria,3T23J@506|Alcaligenaceae	28216|Betaproteobacteria	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HKD3_k127_4960592_0	887898.HMPREF0551_1731	2.257e-274	874.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1K28Y@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD3_k127_4960592_8	518766.Rmar_2587	1.391e-23	106.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD3_k127_4960592_1	1379270.AUXF01000003_gene3535	2.794e-155	505.0	COG1007@1|root,COG1007@2|Bacteria,1ZUR0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_4960592_3	1379270.AUXF01000003_gene3534	2.118e-100	330.0	COG1008@1|root,COG1008@2|Bacteria,1ZUBB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_5020804_3	1366050.N234_16730	2.517e-71	243.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,1K2ZA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA photolyase	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD3_k127_5020804_0	1198452.Jab_2c28650	0.0	1082.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,473JA@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD3_k127_5020804_1	859657.RPSI07_2679	2.679e-192	626.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,1K338@119060|Burkholderiaceae	28216|Betaproteobacteria	NT	chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
HKD3_k127_5020804_8	887898.HMPREF0551_0041	1.201e-35	141.0	COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria,1K59Q@119060|Burkholderiaceae	28216|Betaproteobacteria	NT	Two component signalling adaptor domain	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
HKD3_k127_5020804_5	204773.HEAR2746	6.587e-51	184.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,474F2@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	cheY-homologous receiver domain	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HKD3_k127_5020804_4	497321.C664_18027	5.219e-62	216.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KWB2@206389|Rhodocyclales	206389|Rhodocyclales	T	cheY-homologous receiver domain	pilG	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HKD3_k127_5020804_9	375286.mma_2957	3.532e-32	128.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,474ZG@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Rubredoxin	rubA	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD3_k127_5020804_7	1301098.PKB_4741	5.096e-41	159.0	COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Belongs to the N-Me-Phe pilin family	pilA	-	-	ko:K02650,ko:K02655	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
HKD3_k127_5020804_2	887898.HMPREF0551_0036	1.872e-113	370.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,1K7CB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	cAMP phosphodiesterases class-II	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HKD3_k127_5020804_6	640081.Dsui_1452	2.347e-50	184.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,2KVW3@206389|Rhodocyclales	206389|Rhodocyclales	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD3_k127_5021843_11	1217718.ALOU01000038_gene3360	6.357e-73	250.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,1K04R@119060|Burkholderiaceae	28216|Betaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD3_k127_5021843_2	887898.HMPREF0551_2502	4.866e-150	505.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,1K1FD@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD3_k127_5021843_10	1163617.SCD_n02623	7.635e-91	317.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD3_k127_5021843_18	95619.PM1_0205300	8.841e-11	75.0	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
HKD3_k127_5021843_3	1005048.CFU_0614	4.008e-123	417.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,4729N@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HKD3_k127_5021843_8	667632.KB890217_gene4774	4.289e-105	351.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,1K2ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD3_k127_5021843_0	887898.HMPREF0551_2507	1.917e-219	700.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria,1K0U1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD3_k127_5021843_6	85643.Tmz1t_0443	2.735e-115	384.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,2KUFV@206389|Rhodocyclales	206389|Rhodocyclales	L	A G-specific	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD3_k127_5021843_13	159087.Daro_0066	1.086e-52	195.0	COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,2KWC8@206389|Rhodocyclales	206389|Rhodocyclales	S	peptidase S16	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HKD3_k127_5021843_7	887898.HMPREF0551_2509	9.016e-111	366.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,1K3DN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Displays ATPase and GTPase activities	yhbJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD3_k127_5021843_5	864073.HFRIS_021601	2.009e-115	383.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,472H4@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD3_k127_5021843_12	1031711.RSPO_c02999	3.825e-62	217.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,1K48R@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD3_k127_5021843_16	1120999.JONM01000010_gene4058	1.121e-34	138.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,2KRN2@206351|Neisseriales	206351|Neisseriales	J	ribosomal subunit interface protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HKD3_k127_5021843_1	1031711.RSPO_c02996	2.491e-164	531.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,1K1FU@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD3_k127_5021843_4	864073.HFRIS_002709	2.889e-117	381.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,47239@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	transport system, ATPase component	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5021843_14	93220.LV28_17110	5.938e-52	191.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,2VRDV@28216|Betaproteobacteria,1KH64@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HKD3_k127_5021843_17	1144319.PMI16_01215	1.551e-27	119.0	COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VWU0@28216|Betaproteobacteria,474CV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HKD3_k127_5021843_15	887898.HMPREF0551_2517	5.714e-49	180.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,1K026@119060|Burkholderiaceae	28216|Betaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD3_k127_5021843_9	944435.AXAJ01000002_gene4312	2.402e-91	305.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,1K0GY@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD3_k127_5033800_19	557598.LHK_00830	2.223e-99	332.0	COG1216@1|root,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,2VJUA@28216|Betaproteobacteria,2KQGQ@206351|Neisseriales	206351|Neisseriales	M	Glycosyltransferase like family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
HKD3_k127_5033800_7	557598.LHK_00829	2.098e-167	537.0	COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2VMU1@28216|Betaproteobacteria,2KS2V@206351|Neisseriales	206351|Neisseriales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_5033800_0	557598.LHK_00828	6.333e-218	691.0	COG0110@1|root,COG1215@1|root,COG0110@2|Bacteria,COG1215@2|Bacteria,1QUG1@1224|Proteobacteria,2VTWK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_5033800_12	557598.LHK_00827	2.843e-134	439.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VIXP@28216|Betaproteobacteria,2KQF6@206351|Neisseriales	206351|Neisseriales	M	Psort location OuterMembrane, score 9.92	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD3_k127_5033800_2	557598.LHK_00826	8.795e-207	653.0	2BUET@1|root,32PQT@2|Bacteria,1RG6G@1224|Proteobacteria	1224|Proteobacteria	S	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD3_k127_5033800_10	557598.LHK_00837	3.627e-148	478.0	COG4641@1|root,COG4641@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
HKD3_k127_5033800_17	614083.AWQR01000005_gene944	6.634e-102	337.0	COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,2VMZX@28216|Betaproteobacteria,4AAJU@80864|Comamonadaceae	28216|Betaproteobacteria	K	response regulator, receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_5033800_18	1347369.CCAD010000056_gene4346	3.667e-100	347.0	COG1946@1|root,COG1946@2|Bacteria,1V302@1239|Firmicutes,4HG3J@91061|Bacilli,1ZDYK@1386|Bacillus	91061|Bacilli	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD3_k127_5033800_22	204773.HEAR1371	9.821e-43	162.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria,4778E@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD3_k127_5033800_21	234267.Acid_4680	6.917e-52	187.0	COG3189@1|root,COG3189@2|Bacteria,3Y86R@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD3_k127_5033800_11	1110502.TMO_0531	3.239e-137	447.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,2JS9F@204441|Rhodospirillales	204441|Rhodospirillales	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD3_k127_5033800_4	1121271.AUCM01000020_gene2817	6.895e-194	633.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_5033800_20	864051.BurJ1DRAFT_4598	6.499e-77	261.0	COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,2VVGN@28216|Betaproteobacteria,1KMHB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_5033800_23	614083.AWQR01000018_gene1879	8.474e-42	161.0	COG2329@1|root,COG2329@2|Bacteria,1N5D1@1224|Proteobacteria,2WFVP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD3_k127_5033800_1	1110502.TMO_0513	5.795e-212	672.0	COG0318@1|root,COG0318@2|Bacteria,1PFVK@1224|Proteobacteria,2V7RC@28211|Alphaproteobacteria,2JWIV@204441|Rhodospirillales	204441|Rhodospirillales	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD3_k127_5033800_6	1380394.JADL01000002_gene1157	6.577e-179	569.0	COG0683@1|root,COG0683@2|Bacteria,1MV1Z@1224|Proteobacteria,2TRTD@28211|Alphaproteobacteria,2JT93@204441|Rhodospirillales	204441|Rhodospirillales	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_5033800_14	1380394.JADL01000002_gene1158	1.646e-127	433.0	COG4177@1|root,COG4177@2|Bacteria,1P0DF@1224|Proteobacteria,2TUBF@28211|Alphaproteobacteria,2JUXE@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_5033800_13	1408164.MOLA814_02202	4.872e-131	436.0	COG0559@1|root,COG0559@2|Bacteria,1MXGK@1224|Proteobacteria,2VPMF@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5033800_16	1408164.MOLA814_02201	1.58e-102	338.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2W8Y3@28216|Betaproteobacteria,1KQ24@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_5033800_15	1408164.MOLA814_02200	3.243e-107	358.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VNH8@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5033800_3	1384054.N790_05530	9.127e-200	635.0	COG1012@1|root,COG1012@2|Bacteria,1QWN5@1224|Proteobacteria,1T508@1236|Gammaproteobacteria,1X5AD@135614|Xanthomonadales	135614|Xanthomonadales	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD3_k127_5033800_8	1100720.ALKN01000033_gene732	2.168e-154	493.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VJA3@28216|Betaproteobacteria,4ABMN@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5033800_9	1380394.JADL01000003_gene5078	5.594e-149	476.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TSIQ@28211|Alphaproteobacteria,2JR00@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5033800_5	1100720.ALKN01000033_gene730	1.006e-190	600.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,4AB9R@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_5099809_4	159087.Daro_0701	1.149e-93	328.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria,2KVB8@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD3_k127_5099809_3	648757.Rvan_3533	8.297e-116	395.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2TR8A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
HKD3_k127_5099809_1	522306.CAP2UW1_2671	5.003e-188	593.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,1KQ81@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD3_k127_5099809_6	395495.Lcho_3119	7.879e-76	263.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2VPZB@28216|Betaproteobacteria,1KK59@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD3_k127_5099809_7	1223521.BBJX01000016_gene692	1.565e-33	136.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,4AEZN@80864|Comamonadaceae	28216|Betaproteobacteria	K	SMART regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HKD3_k127_5099809_5	391735.Veis_2048	6.941e-85	287.0	COG0637@1|root,COG0637@2|Bacteria,1NF90@1224|Proteobacteria,2VTII@28216|Betaproteobacteria,4AJ4I@80864|Comamonadaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD3_k127_5099809_0	1123487.KB892839_gene234	6.554e-199	623.0	COG2220@1|root,COG2220@2|Bacteria,1N50Z@1224|Proteobacteria	1224|Proteobacteria	S	Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions	ulaG	GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009056,GO:0009109,GO:0009111,GO:0009987,GO:0016052,GO:0016054,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019854,GO:0030145,GO:0035460,GO:0042365,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0051186,GO:0051187,GO:0052689,GO:0071704,GO:1901575	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b4192,iAPECO1_1312.APECO1_2200,iBWG_1329.BWG_3904,iEC55989_1330.EC55989_4749,iECDH10B_1368.ECDH10B_4387,iECH74115_1262.ECH74115_5708,iECIAI1_1343.ECIAI1_4425,iECIAI39_1322.ECIAI39_4657,iECO111_1330.ECO111_5022,iECO26_1355.ECO26_5358,iECSE_1348.ECSE_4490,iECSP_1301.ECSP_5292,iECUMN_1333.ECUMN_4725,iECW_1372.ECW_m4554,iEKO11_1354.EKO11_4120,iEcE24377_1341.EcE24377A_4752,iEcHS_1320.EcHS_A4436,iEcolC_1368.EcolC_3821,iJO1366.b4192,iUTI89_1310.UTI89_C4792,iWFL_1372.ECW_m4554,iY75_1357.Y75_RS21830,iYL1228.KPN_04585,ic_1306.c5280	Lactamase_B_2,Lactamase_B_3
HKD3_k127_5099809_2	742823.HMPREF9465_01518	5.212e-120	395.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,4PQX9@995019|Sutterellaceae	28216|Betaproteobacteria	P	ATPases associated with a variety of cellular activities	ugpC	-	3.6.3.20	ko:K05816,ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE_2
HKD3_k127_5124833_11	1223521.BBJX01000002_gene2860	1.945e-86	289.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c oxidase, subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD3_k127_5124833_12	1454004.AW11_01055	2.779e-78	281.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VM89@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD3_k127_5124833_14	522306.CAP2UW1_1788	2.43e-71	250.0	COG1999@1|root,COG1999@2|Bacteria,1N6WC@1224|Proteobacteria,2VMIP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM electron transport protein SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD3_k127_5124833_4	522306.CAP2UW1_1327	4.803e-136	454.0	COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2VNFS@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,Fer4_7,FlpD
HKD3_k127_5124833_20	1437824.BN940_02361	4.236e-39	156.0	2CB7M@1|root,31H4T@2|Bacteria,1MYWT@1224|Proteobacteria,2VSTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5124833_2	1223521.BBJX01000002_gene2865	3.247e-160	521.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HKD3_k127_5124833_23	1223521.BBJX01000002_gene2857	8.165e-10	72.0	COG1612@1|root,COG1612@2|Bacteria,1NDQQ@1224|Proteobacteria,2VWPV@28216|Betaproteobacteria,4AGYI@80864|Comamonadaceae	28216|Betaproteobacteria	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD3_k127_5124833_9	305700.B447_00570	8.896e-104	353.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,2KU72@206389|Rhodocyclales	206389|Rhodocyclales	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD3_k127_5124833_15	246197.MXAN_7164	4.399e-59	222.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_5124833_10	1454004.AW11_01260	1.658e-93	318.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
HKD3_k127_5124833_17	1538295.JY96_20990	1.62e-56	205.0	COG2078@1|root,COG2078@2|Bacteria,1PV46@1224|Proteobacteria,2WB31@28216|Betaproteobacteria,1KP5N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
HKD3_k127_5124833_0	1123368.AUIS01000008_gene2237	1.348e-176	569.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T90P@1236|Gammaproteobacteria,2NDQR@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD3_k127_5124833_8	1000565.METUNv1_01567	2.513e-109	385.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,2KZTK@206389|Rhodocyclales	206389|Rhodocyclales	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
HKD3_k127_5124833_7	399739.Pmen_2781	1.983e-113	387.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0471 Di- and tricarboxylate transporters	sdcS	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
HKD3_k127_5124833_13	1122604.JONR01000009_gene2433	9.985e-75	259.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1X3YK@135614|Xanthomonadales	135614|Xanthomonadales	P	nucleotidase	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD3_k127_5124833_3	396588.Tgr7_1406	3.982e-139	479.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales	135613|Chromatiales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD3_k127_5124833_16	640510.BC1001_4818	1.062e-58	208.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,1K7QD@119060|Burkholderiaceae	28216|Betaproteobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD3_k127_5124833_21	857087.Metme_1805	1.16e-20	98.0	2DP14@1|root,3303I@2|Bacteria,1N7JW@1224|Proteobacteria,1TNDU@1236|Gammaproteobacteria,1XGK3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5124833_19	1218074.BAXZ01000009_gene2277	1.549e-40	158.0	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,2VSJ5@28216|Betaproteobacteria,1K83E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
HKD3_k127_5124833_6	768671.ThimaDRAFT_0738	1.247e-122	404.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1WWNT@135613|Chromatiales	135613|Chromatiales	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD3_k127_5124833_18	243233.MCA0197	2.087e-42	161.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria,1XFJZ@135618|Methylococcales	135618|Methylococcales	I	COG0575 CDP-diglyceride synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
HKD3_k127_5124833_22	316058.RPB_2702	7.09e-15	84.0	COG2329@1|root,COG2329@2|Bacteria,1NDM8@1224|Proteobacteria,2UG48@28211|Alphaproteobacteria,3JYVV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative mono-oxygenase ydhR	-	-	-	-	-	-	-	-	-	-	-	-	ydhR
HKD3_k127_5124833_5	2340.JV46_13030	6.4e-135	445.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S7ID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_5124833_1	338963.Pcar_1239	2.064e-174	556.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJG3@28221|Deltaproteobacteria,43TT3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD3_k127_5215542_1	1144319.PMI16_02309	7.148e-115	377.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,473W4@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD3_k127_5215542_3	76114.ebA4236	1.309e-107	360.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2VJ3C@28216|Betaproteobacteria,2KVXZ@206389|Rhodocyclales	206389|Rhodocyclales	O	protein required for cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD3_k127_5215542_5	1175306.GWL_35720	2.755e-48	184.0	COG1999@1|root,COG1999@2|Bacteria,1RHK3@1224|Proteobacteria,2VRBY@28216|Betaproteobacteria,473TQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	signal sequence binding	sco1	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5215542_6	748247.AZKH_3634	5.234e-48	182.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,2VSAZ@28216|Betaproteobacteria,2KWKA@206389|Rhodocyclales	206389|Rhodocyclales	S	SURF1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
HKD3_k127_5215542_7	1217718.ALOU01000038_gene3382	2.314e-24	104.0	2E53D@1|root,32ZWH@2|Bacteria,1N979@1224|Proteobacteria,2VVRY@28216|Betaproteobacteria,1K9G5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
HKD3_k127_5215542_0	477184.KYC_21966	1.463e-119	392.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,3T2UM@506|Alcaligenaceae	28216|Betaproteobacteria	C	Heme copper-type cytochrome quinol oxidase subunit 3	coxC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD3_k127_5215542_8	402626.Rpic_0222	5.434e-07	60.0	2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria,2VXNC@28216|Betaproteobacteria,1KABT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2970)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2970
HKD3_k127_5215542_4	1095769.CAHF01000014_gene2983	1.738e-69	241.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,4728X@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	cytochrome C oxidase	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD3_k127_5215542_2	1247649.D560_1609	8.934e-112	362.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,3T1DV@506|Alcaligenaceae	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD3_k127_5224413_37	977880.RALTA_A1493	2.672e-69	255.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,1K0KG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD3_k127_5224413_27	795666.MW7_1966	1.19e-100	354.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1K15A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD3_k127_5224413_34	1097668.BYI23_A012470	3.799e-72	255.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2VQ24@28216|Betaproteobacteria,1JZWI@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD3_k127_5224413_43	640081.Dsui_2654	7.439e-61	224.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,2KUK8@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HKD3_k127_5224413_55	1123392.AQWL01000007_gene924	8.002e-34	146.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,2VT2B@28216|Betaproteobacteria,1KT2J@119069|Hydrogenophilales	119069|Hydrogenophilales	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD3_k127_5224413_26	323848.Nmul_A1381	2.354e-103	352.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,372C1@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TatD related DNase	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD3_k127_5224413_49	1223521.BBJX01000005_gene2047	6.367e-42	164.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VPIV@28216|Betaproteobacteria,4ADCG@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Ankyrin	arp3	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
HKD3_k127_5224413_32	864051.BurJ1DRAFT_4038	5.027e-82	302.0	COG0464@1|root,COG0464@2|Bacteria,1RFP5@1224|Proteobacteria	1224|Proteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,BCS1_N
HKD3_k127_5224413_60	748247.AZKH_2774	6.867e-24	106.0	COG4274@1|root,COG4274@2|Bacteria,1N29P@1224|Proteobacteria,2WFXY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD3_k127_5224413_17	1396858.Q666_05280	3.147e-155	511.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,464B6@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_5224413_48	420662.Mpe_A2251	7.754e-46	175.0	2ATZM@1|root,31JJE@2|Bacteria,1RIFX@1224|Proteobacteria,2VSS3@28216|Betaproteobacteria,1KM95@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5224413_22	1095769.CAHF01000022_gene349	5.042e-138	462.0	COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,2VPP7@28216|Betaproteobacteria,4724Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HKD3_k127_5224413_33	887898.HMPREF0551_1229	2.491e-79	284.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2VQIR@28216|Betaproteobacteria,1K4JU@119060|Burkholderiaceae	28216|Betaproteobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	nudC	GO:0003674,GO:0003824,GO:0004551,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0035529,GO:0043167,GO:0043169,GO:0046872,GO:0046914	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD3_k127_5224413_57	314345.SPV1_09043	1.931e-33	148.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	ngr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubrerythrin
HKD3_k127_5224413_9	296591.Bpro_2169	3.687e-179	566.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2VJ6S@28216|Betaproteobacteria,4AA2B@80864|Comamonadaceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	acdS	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
HKD3_k127_5224413_11	1207063.P24_13193	1.758e-173	559.0	COG5476@1|root,COG5476@2|Bacteria,1NS9S@1224|Proteobacteria,2UNYM@28211|Alphaproteobacteria,2JVCG@204441|Rhodospirillales	204441|Rhodospirillales	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HKD3_k127_5224413_35	1392838.AWNM01000008_gene1496	3.838e-72	256.0	COG3181@1|root,COG3181@2|Bacteria,1MX9X@1224|Proteobacteria,2VKWC@28216|Betaproteobacteria,3T6VM@506|Alcaligenaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_5224413_39	1223521.BBJX01000005_gene2173	6.763e-68	244.0	COG4977@1|root,COG4977@2|Bacteria,1R77N@1224|Proteobacteria,2VT1G@28216|Betaproteobacteria,4AGWM@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD3_k127_5224413_10	1121106.JQKB01000004_gene2325	2.287e-175	562.0	COG0154@1|root,COG0154@2|Bacteria,1MUKC@1224|Proteobacteria,2TTUD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD3_k127_5224413_40	864051.BurJ1DRAFT_0802	8.506e-66	236.0	COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2VQ0N@28216|Betaproteobacteria,1KM8G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD3_k127_5224413_2	1288494.EBAPG3_26320	2.535e-306	989.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
HKD3_k127_5224413_4	338969.Rfer_2478	5.558e-254	794.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VI39@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_5224413_28	349521.HCH_01644	2.8e-99	346.0	COG0642@1|root,COG2204@1|root,COG2204@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1XNAD@135619|Oceanospirillales	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD3_k127_5224413_21	1218076.BAYB01000043_gene5761	6.394e-144	480.0	COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,1K1MC@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34	mnmC	-	2.1.1.61	ko:K15461	-	-	R00601,R08702	RC00003,RC00053,RC00060,RC01483	ko00000,ko01000,ko03016	-	-	-	DAO,Methyltransf_30
HKD3_k127_5224413_52	1267005.KB911260_gene3526	7.021e-37	160.0	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD3_k127_5224413_8	1219031.BBJR01000001_gene531	7.114e-195	630.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,4ACI6@80864|Comamonadaceae	28216|Betaproteobacteria	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
HKD3_k127_5224413_58	118166.JH976537_gene614	3.542e-29	124.0	2E94E@1|root,333D9@2|Bacteria,1GFAP@1117|Cyanobacteria,1HGFG@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
HKD3_k127_5224413_44	1417296.U879_09625	4.221e-58	229.0	COG0673@1|root,COG0673@2|Bacteria,1R7EF@1224|Proteobacteria,2TT4H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD3_k127_5224413_6	62928.azo2852	1.874e-229	718.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,2KVXT@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_5224413_20	1095769.CAHF01000011_gene2303	7.058e-145	484.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria,4759H@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD3_k127_5224413_51	1121035.AUCH01000003_gene1385	7.792e-38	163.0	COG4191@1|root,COG4191@2|Bacteria,1P46F@1224|Proteobacteria,2WI0G@28216|Betaproteobacteria,2KZXV@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD3_k127_5224413_45	1288494.EBAPG3_18790	5.222e-57	207.0	COG0745@1|root,COG0745@2|Bacteria,1RA00@1224|Proteobacteria,2VRMX@28216|Betaproteobacteria,371UR@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_5224413_1	795666.MW7_1892	0.0	1714.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,1K0RI@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD3_k127_5224413_0	1231391.AMZF01000010_gene1692	0.0	1746.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,3T1HA@506|Alcaligenaceae	28216|Betaproteobacteria	EQ	5-oxoprolinase	oplaH	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HKD3_k127_5224413_41	314265.R2601_23076	6.023e-65	230.0	COG1794@1|root,COG1794@2|Bacteria,1MW3C@1224|Proteobacteria,2TRH9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	racemase activity, acting on amino acids and derivatives	MA20_00660	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5224413_18	864051.BurJ1DRAFT_4034	7.436e-152	495.0	COG1638@1|root,COG1638@2|Bacteria,1MVYB@1224|Proteobacteria,2VIQ9@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TRAP-type C4-dicarboxylate transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_5224413_42	397945.Aave_3298	1.795e-64	225.0	COG3090@1|root,COG3090@2|Bacteria,1N01Z@1224|Proteobacteria	1224|Proteobacteria	G	transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_5224413_7	397945.Aave_3299	2.103e-226	707.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,4ACFD@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_5224413_14	1366050.N234_07510	3.278e-160	514.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,1K2HR@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Dehydrogenase	-	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO,NAD_binding_8
HKD3_k127_5224413_29	1005048.CFU_2411	6.932e-93	328.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,472C5@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136	ko:K17758	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD3_k127_5224413_16	414684.RC1_3592	1.181e-155	509.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2JPNA@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD3_k127_5224413_31	360910.BAV1967	8.086e-84	287.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,3T3FU@506|Alcaligenaceae	28216|Betaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis ATPase component	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_5224413_36	365046.Rta_19160	3.255e-70	251.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2VRIQ@28216|Betaproteobacteria,4ADGS@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM lipolytic protein G-D-S-L family	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HKD3_k127_5224413_59	1502852.FG94_02915	5.849e-28	124.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	CBM60,DUF4214
HKD3_k127_5224413_62	196367.JNFG01000017_gene4146	3.414e-06	59.0	COG0596@1|root,COG0596@2|Bacteria,1R9VJ@1224|Proteobacteria,2VRIS@28216|Betaproteobacteria,1K0SG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD3_k127_5224413_23	296591.Bpro_4260	3.275e-128	423.0	COG0500@1|root,COG2226@2|Bacteria,1QYJ7@1224|Proteobacteria,2VP33@28216|Betaproteobacteria	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_5224413_19	296591.Bpro_4260	1.964e-147	482.0	COG0500@1|root,COG2226@2|Bacteria,1QYJ7@1224|Proteobacteria,2VP33@28216|Betaproteobacteria	28216|Betaproteobacteria	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_5224413_30	1095769.CAHF01000013_gene3217	9.535e-87	296.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,473GA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Haemolysin-III related	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD3_k127_5224413_24	640510.BC1001_0696	4.288e-111	362.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VH2U@28216|Betaproteobacteria,1K0MJ@119060|Burkholderiaceae	28216|Betaproteobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
HKD3_k127_5224413_53	1458357.BG58_13370	4.789e-36	148.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,1K1FV@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
HKD3_k127_5224413_54	272560.BPSL2660	3.867e-35	155.0	COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,2VMRF@28216|Betaproteobacteria,1K0PC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly	ureE	-	-	ko:K03187	-	-	-	-	ko00000	-	-	-	UreE_C,UreE_N
HKD3_k127_5224413_3	748280.NH8B_2034	2.081e-303	946.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,2KPCR@206351|Neisseriales	206351|Neisseriales	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HKD3_k127_5224413_50	1453503.AU05_05880	6.257e-41	161.0	COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,1S8UP@1236|Gammaproteobacteria,1YGI5@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active	ureB	GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009039,GO:0016787,GO:0016810,GO:0016811	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_1322,iECO103_1326.ECO103_3798,iECO111_1330.ECO111_1228,iECSP_1301.ECSP_1250,iECs_1301.ECs1323,iUMNK88_1353.UMNK88_1200,iZ_1308.Z1144,iZ_1308.Z1583	Urease_beta
HKD3_k127_5224413_47	95619.PM1_0204275	4.995e-49	178.0	COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,1S65Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_gamma
HKD3_k127_5224413_46	1500894.JQNN01000001_gene835	3.252e-50	191.0	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,2VHXH@28216|Betaproteobacteria,4723V@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
HKD3_k127_5224413_38	1089551.KE386572_gene2829	6.843e-69	254.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2TS23@28211|Alphaproteobacteria,4BQ2Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	urtE	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
HKD3_k127_5224413_25	1454004.AW11_04074	1.425e-108	362.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2VIX4@28216|Betaproteobacteria,1KQAM@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Branched-chain amino acid ATP-binding cassette transporter	urtD	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5224413_15	1454004.AW11_04073	1.62e-156	502.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,1KQFE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Branched-chain amino acid transport system / permease component	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD3_k127_5224413_12	1123487.KB892836_gene3149	2.55e-164	532.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,2KV7K@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD3_k127_5224413_5	742159.HMPREF0004_5134	1.521e-230	721.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,2VI6J@28216|Betaproteobacteria,3T5K8@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems periplasmic component	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
HKD3_k127_5224413_13	196490.AUEZ01000156_gene8	2.521e-163	530.0	COG4716@1|root,COG4716@2|Bacteria,1MVTV@1224|Proteobacteria,2TR2G@28211|Alphaproteobacteria,3JSEG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	MCRA family	-	-	4.2.1.53	ko:K10254	-	-	-	-	ko00000,ko01000	-	-	-	MCRA
HKD3_k127_5224413_61	1088721.NSU_0160	1.331e-10	68.0	COG2272@1|root,COG2272@2|Bacteria,1P0SV@1224|Proteobacteria,2UUWE@28211|Alphaproteobacteria,2K72M@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5224413_56	85643.Tmz1t_2947	1.043e-33	131.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria	1224|Proteobacteria	C	Ferredoxin	fdxB	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4
HKD3_k127_5411835_3	1265502.KB905930_gene1503	6.854e-156	512.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,4A9R4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD3_k127_5411835_6	292.DM42_2835	7.335e-83	287.0	COG1024@1|root,COG1024@2|Bacteria,1P3FI@1224|Proteobacteria,2VHYZ@28216|Betaproteobacteria,1K1J3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG2	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_5411835_1	859657.RPSI07_1415	1.031e-171	568.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,1K1T0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD3_k127_5411835_5	1095769.CAHF01000011_gene2277	2.35e-89	301.0	COG0625@1|root,COG0625@2|Bacteria,1RAP2@1224|Proteobacteria,2VQGV@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HKD3_k127_5411835_2	765910.MARPU_00485	9.523e-164	551.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,1WWEX@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD3_k127_5411835_4	360910.BAV1419	9.447e-91	325.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,3T388@506|Alcaligenaceae	28216|Betaproteobacteria	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
HKD3_k127_5411835_0	882378.RBRH_03591	7.714e-175	561.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,1K18P@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_5411835_7	1137799.GZ78_06660	5.739e-29	123.0	COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1XKRS@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the ArsC family	-	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,Glutaredoxin
HKD3_k127_5411835_8	1095769.CAHF01000011_gene2253	5.561e-17	83.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VHU7@28216|Betaproteobacteria,473F3@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	Type II/IV secretion system protein	pilT2	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD3_k127_5483345_4	1123368.AUIS01000008_gene2247	3.275e-112	385.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,2NC8X@225057|Acidithiobacillales	225057|Acidithiobacillales	O	hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD3_k127_5483345_2	713587.THITH_06840	3.795e-198	632.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales	135613|Chromatiales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD3_k127_5483345_16	1437882.AZRU01000002_gene2431	4.306e-15	85.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD3_k127_5483345_1	1123368.AUIS01000008_gene2250	5.371e-298	934.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,2NC37@225057|Acidithiobacillales	225057|Acidithiobacillales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD3_k127_5483345_3	159087.Daro_3978	1.501e-127	416.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,2VJKH@28216|Betaproteobacteria,2KUUA@206389|Rhodocyclales	206389|Rhodocyclales	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD3_k127_5483345_11	322710.Avin_50490	9.235e-33	135.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HKD3_k127_5483345_8	1123368.AUIS01000008_gene2253	1.679e-52	204.0	COG0374@1|root,COG0374@2|Bacteria,1R6ND@1224|Proteobacteria,1RZ8Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Ni,Fe-hydrogenase I large subunit	hoxV	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
HKD3_k127_5483345_9	384765.SIAM614_29551	1.635e-33	138.0	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2U0HG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	[NiFe]-hydrogenase assembly, chaperone, HybE	hupJ	-	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE,Rubredoxin
HKD3_k127_5483345_10	1192124.LIG30_1253	9.139e-33	130.0	COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria,2VWD0@28216|Betaproteobacteria,1K9A5@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Rubredoxin	hoxR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD3_k127_5483345_6	1192124.LIG30_1252	2.206e-76	265.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2VKNQ@28216|Betaproteobacteria,1K5MW@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM HupH hydrogenase expression protein	hoxQ	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
HKD3_k127_5483345_12	420662.Mpe_A2820	1.071e-29	129.0	COG0526@1|root,COG0526@2|Bacteria,1RJ41@1224|Proteobacteria,2VSQM@28216|Betaproteobacteria,1KMBG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Hydrogenase-1 expression protein HyaE	hoxO	-	-	ko:K03619	-	-	-	-	ko00000	-	-	-	HyaE
HKD3_k127_5483345_15	187303.BN69_2333	3.328e-23	110.0	COG0298@1|root,COG0298@2|Bacteria,1N9Z3@1224|Proteobacteria,2UD4G@28211|Alphaproteobacteria,3717U@31993|Methylocystaceae	28211|Alphaproteobacteria	O	HupF/HypC family	hupF	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD3_k127_5483345_7	1105367.CG50_02340	4.524e-61	218.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2U2IN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	hydrogenase expression formation protein	hupD	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD3_k127_5483345_14	62928.azo3789	1.748e-23	112.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2VU0Y@28216|Betaproteobacteria,2KXJ6@206389|Rhodocyclales	206389|Rhodocyclales	K	Helix-turn-helix	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HKD3_k127_5483345_5	1123399.AQVE01000006_gene3541	7.401e-86	289.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,1RNTH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	b-type cytochrome subunit	hyaC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD3_k127_5483345_0	62928.azo3787	0.0	1022.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,2KV5T@206389|Rhodocyclales	206389|Rhodocyclales	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD3_k127_5483345_13	1123256.KB907925_gene1302	4.715e-29	117.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	small subunit	hyaA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040	NiFe_hyd_SSU_C,Oxidored_q6
HKD3_k127_5567565_38	1157708.KB907454_gene2873	0.0002224	46.0	COG3090@1|root,COG3090@2|Bacteria,1NDFB@1224|Proteobacteria,2W4QP@28216|Betaproteobacteria,4AIFI@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_5567565_13	1298867.AUES01000010_gene5821	6.037e-104	364.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria,3JTC3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_18675	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_5567565_11	1392838.AWNM01000097_gene130	3.652e-113	408.0	COG1014@1|root,COG1014@2|Bacteria,1MV7Q@1224|Proteobacteria,2VMSN@28216|Betaproteobacteria,3T2S0@506|Alcaligenaceae	28216|Betaproteobacteria	C	indolepyruvate oxidoreductase subunit B	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD3_k127_5567565_3	1123504.JQKD01000013_gene1068	5.02e-321	999.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,4AASY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Indolepyruvate ferredoxin oxidoreductase	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_5567565_26	1123504.JQKD01000027_gene4101	1.962e-50	191.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,4AB6Z@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_5567565_31	857087.Metme_0242	1.31e-30	136.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1SA8X@1236|Gammaproteobacteria,1XFJF@135618|Methylococcales	135618|Methylococcales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD3_k127_5567565_15	535289.Dtpsy_1677	1.221e-102	340.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,4AA1W@80864|Comamonadaceae	28216|Betaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_5567565_29	84531.JMTZ01000012_gene2956	4.431e-37	147.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,1SD2H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	protein, possibly involved in utilization of glycolate and propanediol	glcG	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
HKD3_k127_5567565_4	62928.azo2473	1.171e-202	657.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VH71@28216|Betaproteobacteria,2KY2C@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde dehydrogenase family	-	-	1.2.1.28	ko:K00141	ko00622,ko00623,ko00627,ko01100,ko01120,ko01220,map00622,map00623,map00627,map01100,map01120,map01220	M00537,M00538	R01293,R01419,R05289,R05663,R05664,R07667	RC00075	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_5567565_20	1281779.H009_11391	2.992e-78	290.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSCA@28211|Alphaproteobacteria,4BCWK@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5567565_23	1535287.JP74_16030	1.366e-70	261.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,3N9E3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5567565_18	688245.CtCNB1_1145	2.521e-84	302.0	COG4177@1|root,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2WEXH@28216|Betaproteobacteria,4AJPI@80864|Comamonadaceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5567565_19	1535287.JP74_16020	8.719e-83	284.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3N7Q6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	MA20_29495	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5567565_7	1038859.AXAU01000001_gene3899	2.888e-159	514.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,3JU3U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_29490	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_5567565_0	887898.HMPREF0551_2170	0.0	1908.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria	1224|Proteobacteria	E	methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD3_k127_5567565_28	870187.Thini_1466	1.628e-39	159.0	COG3791@1|root,COG3791@2|Bacteria,1REMP@1224|Proteobacteria,1SXS7@1236|Gammaproteobacteria,462ZE@72273|Thiotrichales	72273|Thiotrichales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_5567565_36	1219031.BBJR01000001_gene574	3.806e-19	91.0	2E4QE@1|root,32ZIZ@2|Bacteria,1NCEP@1224|Proteobacteria,2VU6H@28216|Betaproteobacteria,4AFIG@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5567565_27	1123393.KB891316_gene1854	9.882e-41	162.0	COG2920@1|root,COG2920@2|Bacteria,1N2HP@1224|Proteobacteria,2VVGF@28216|Betaproteobacteria,1KT6M@119069|Hydrogenophilales	119069|Hydrogenophilales	P	DsrC like protein	-	-	-	-	-	-	-	-	-	-	-	-	DsrC
HKD3_k127_5567565_30	1163617.SCD_n00799	1.042e-31	125.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HKD3_k127_5567565_21	1123368.AUIS01000007_gene2787	4.782e-73	248.0	COG2210@1|root,COG2210@2|Bacteria,1RCMJ@1224|Proteobacteria,1S2XA@1236|Gammaproteobacteria,2NCNX@225057|Acidithiobacillales	225057|Acidithiobacillales	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD3_k127_5567565_32	864051.BurJ1DRAFT_3343	6.288e-28	124.0	COG1974@1|root,COG1974@2|Bacteria,1QUQ8@1224|Proteobacteria,2VWS0@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
HKD3_k127_5567565_24	1123393.KB891316_gene1907	1.877e-69	248.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,2VZZT@28216|Betaproteobacteria,1KSKS@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5567565_35	1123393.KB891331_gene2946	3.302e-21	103.0	2BW2S@1|root,32QYV@2|Bacteria,1RI5M@1224|Proteobacteria,2VX7W@28216|Betaproteobacteria,1KT27@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5567565_37	864051.BurJ1DRAFT_3344	5.372e-11	66.0	2DRY7@1|root,33DN9@2|Bacteria,1NJPX@1224|Proteobacteria,2VYHU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5567565_17	864051.BurJ1DRAFT_3307	4.212e-92	329.0	COG0599@1|root,COG2146@1|root,COG0599@2|Bacteria,COG2146@2|Bacteria,1RCCG@1224|Proteobacteria	1224|Proteobacteria	P	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Rieske
HKD3_k127_5567565_8	864051.BurJ1DRAFT_3342	3.81e-156	507.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,2VPWB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2
HKD3_k127_5567565_16	864051.BurJ1DRAFT_3311	2.125e-102	342.0	COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,2VN4W@28216|Betaproteobacteria,1KKQ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	DMSO reductase anchor subunit (DmsC)	dmsC	-	-	ko:K21309	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	DmsC
HKD3_k127_5567565_9	864051.BurJ1DRAFT_3312	4.663e-123	436.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,1KKBF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S binding domain	-	-	-	ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4
HKD3_k127_5567565_1	1485544.JQKP01000015_gene2083	0.0	1675.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,44WAX@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.8.5.6	ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_5567565_22	1163617.SCD_n00343	8.511e-71	274.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	narX	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA_3,PilJ
HKD3_k127_5567565_25	864051.BurJ1DRAFT_3321	2.137e-68	256.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,1KM2G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Bacterial regulatory proteins, luxR family	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD3_k127_5567565_12	1266925.JHVX01000020_gene1777	1.077e-104	347.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,371WH@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HKD3_k127_5567565_33	1163617.SCD_n02705	2.958e-23	115.0	COG0316@1|root,COG0316@2|Bacteria,1N8ZN@1224|Proteobacteria,2W5FR@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Iron-sulphur cluster biosynthesis	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD3_k127_5567565_5	1163617.SCD_n02706	2.381e-169	545.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD3_k127_5567565_6	864051.BurJ1DRAFT_3324	4.384e-167	538.0	COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,2VK76@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HKD3_k127_5567565_14	864051.BurJ1DRAFT_3325	3.48e-103	347.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11
HKD3_k127_5567565_34	864051.BurJ1DRAFT_3326	6.138e-23	105.0	2E6CU@1|root,3310G@2|Bacteria,1N0TM@1224|Proteobacteria,2VV3Z@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5567565_2	1485544.JQKP01000005_gene320	0.0	1055.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_21,Fer4_7,Pyr_redox_2,Pyr_redox_3
HKD3_k127_5567565_10	864051.BurJ1DRAFT_3329	1.624e-121	392.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria,1KN5P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Fe-S oxidoreductase	-	-	-	ko:K21834	-	-	-	-	ko00000	-	-	-	CCG,DUF3483,Fer4_8
HKD3_k127_5578806_61	399739.Pmen_2655	3.363e-34	138.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,1S5Y8@1236|Gammaproteobacteria,1YKJT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD3_k127_5578806_65	1340493.JNIF01000003_gene1492	1.607e-24	113.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_5578806_33	1207063.P24_13218	1.866e-118	393.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2TS48@28211|Alphaproteobacteria,2JZ0R@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_5578806_36	450851.PHZ_c1130	3.443e-109	360.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria,2KIC2@204458|Caulobacterales	204458|Caulobacterales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_5578806_55	1163617.SCD_n00994	2.274e-45	168.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,2VSZE@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
HKD3_k127_5578806_19	1123393.KB891326_gene224	7.59e-158	523.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,1KRP0@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_5578806_34	543728.Vapar_3490	1.808e-117	396.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,4AAZA@80864|Comamonadaceae	28216|Betaproteobacteria	V	secretion protein HlyD family	emrA	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD3_k127_5578806_30	1122614.JHZF01000016_gene507	8.75e-126	415.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2PD9T@252301|Oceanicola	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_5578806_37	1313172.YM304_29050	4.133e-94	314.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CNTU@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Sir2 family	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD3_k127_5578806_35	1205680.CAKO01000038_gene1975	2.671e-114	374.0	COG0500@1|root,COG2226@2|Bacteria,1R6ZI@1224|Proteobacteria,2TRC6@28211|Alphaproteobacteria,2JT16@204441|Rhodospirillales	204441|Rhodospirillales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_5578806_17	32057.KB217478_gene6272	1.441e-165	529.0	COG0667@1|root,COG0667@2|Bacteria,1G1XV@1117|Cyanobacteria,1HM9D@1161|Nostocales	1117|Cyanobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_5578806_41	1218084.BBJK01000152_gene7616	4.844e-85	291.0	COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2VQ2H@28216|Betaproteobacteria,1KGNG@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_5578806_68	485913.Krac_5264	1.128e-17	93.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,Acetyltransf_9
HKD3_k127_5578806_73	331869.BAL199_08123	0.0001854	49.0	2ENCC@1|root,33FZW@2|Bacteria,1RGVS@1224|Proteobacteria,2UBUS@28211|Alphaproteobacteria,4BSUI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_2	1441930.Z042_11050	3.958e-306	957.0	COG1018@1|root,COG1233@1|root,COG1018@2|Bacteria,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,404GA@613|Serratia	1236|Gammaproteobacteria	C	Flavin containing amine oxidoreductase	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8
HKD3_k127_5578806_11	1280954.HPO_09520	1.767e-219	696.0	COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,43Y7G@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	COG3670 Lignostilbene-alpha,beta-dioxygenase and related enzymes	-	-	1.13.11.82	ko:K11159,ko:K21822	-	-	-	-	ko00000,ko01000	-	-	-	RPE65
HKD3_k127_5578806_8	1366050.N234_35850	1.026e-231	729.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,1KGZR@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HKD3_k127_5578806_49	1028801.RG1141_CH44430	1.111e-61	224.0	COG2207@1|root,COG2207@2|Bacteria,1RAAS@1224|Proteobacteria,2V2EB@28211|Alphaproteobacteria,4BJ4E@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HKD3_k127_5578806_46	1121933.AUHH01000008_gene1129	4.27e-71	253.0	COG0346@1|root,COG0346@2|Bacteria,2GM8H@201174|Actinobacteria,4DUS6@85009|Propionibacteriales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_5578806_24	745014.OMB55_00013290	1.236e-136	446.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,1S1Y6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD3_k127_5578806_50	864069.MicloDRAFT_00015940	1.34e-61	231.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2U3ZY@28211|Alphaproteobacteria,1JZ61@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_5578806_7	522306.CAP2UW1_0353	7.587e-239	746.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VPYJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD3_k127_5578806_28	640081.Dsui_3428	5.436e-127	415.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VIAS@28216|Betaproteobacteria,2KUF8@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HKD3_k127_5578806_60	1297865.APJD01000039_gene1697	1.718e-35	147.0	2FH03@1|root,348V5@2|Bacteria,1NZ7F@1224|Proteobacteria,2UTTX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_15	555793.WSK_3500	1.318e-173	559.0	COG0154@1|root,COG0154@2|Bacteria,1MWWQ@1224|Proteobacteria,2TSN9@28211|Alphaproteobacteria,2K183@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD3_k127_5578806_47	402626.Rpic_4115	1.335e-69	241.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria,1K5JG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD3_k127_5578806_40	1502851.FG93_05763	2.435e-87	309.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
HKD3_k127_5578806_71	319003.Bra1253DRAFT_00047	1.741e-13	78.0	2AFBI@1|root,315B0@2|Bacteria,1ND3N@1224|Proteobacteria,2UIQ8@28211|Alphaproteobacteria,3K1H2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_63	1276756.AUEX01000002_gene380	2.138e-28	120.0	COG1917@1|root,COG1917@2|Bacteria,1NIS5@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	-
HKD3_k127_5578806_72	395495.Lcho_0043	3.714e-12	67.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1QVGV@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD3_k127_5578806_52	1144312.PMI09_03321	1.793e-49	190.0	2CA6E@1|root,32ZKX@2|Bacteria,1NDUX@1224|Proteobacteria,2UIDZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_18	883126.HMPREF9710_02257	7.79e-164	526.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,478F6@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_5578806_25	1449049.JONW01000011_gene2127	4.168e-135	435.0	COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,2KG1I@204458|Caulobacterales	204458|Caulobacterales	I	PFAM Enoyl-CoA hydratase isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_5578806_42	402881.Plav_0030	2.9e-76	265.0	COG1011@1|root,COG1011@2|Bacteria,1Q69X@1224|Proteobacteria,2TTTP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	hydrolase	MA20_23095	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD3_k127_5578806_44	1231391.AMZF01000010_gene1637	1.218e-72	250.0	COG5553@1|root,COG5553@2|Bacteria,1RE08@1224|Proteobacteria,2WFKT@28216|Betaproteobacteria,3T6SR@506|Alcaligenaceae	28216|Betaproteobacteria	C	metal-dependent enzyme of the double-stranded beta helix superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
HKD3_k127_5578806_0	1157708.KB907462_gene1034	0.0	1457.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,4AC8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	POR,TPP_enzyme_C
HKD3_k127_5578806_20	316056.RPC_2091	2.03e-153	546.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,3JRC0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_21605	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_5578806_23	1549858.MC45_07240	5.733e-141	457.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2K18M@204457|Sphingomonadales	204457|Sphingomonadales	C	Dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD3_k127_5578806_5	1121004.ATVC01000086_gene322	3.483e-267	850.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,2KPZR@206351|Neisseriales	206351|Neisseriales	H	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD3_k127_5578806_13	1121106.JQKB01000010_gene445	4.814e-194	612.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,2JRVP@204441|Rhodospirillales	204441|Rhodospirillales	S	Epoxide hydrolase N terminus	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
HKD3_k127_5578806_69	1288494.EBAPG3_19410	1.53e-15	83.0	2BHIC@1|root,32BKS@2|Bacteria,1PZ7H@1224|Proteobacteria,2VYB8@28216|Betaproteobacteria,373HG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD3_k127_5578806_53	1116375.VEJY3_07780	6.886e-49	198.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,1SAAN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD3_k127_5578806_21	595537.Varpa_4397	1.15e-150	483.0	COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,2VJSC@28216|Betaproteobacteria,4AD30@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HKD3_k127_5578806_45	998674.ATTE01000001_gene2378	2.359e-71	247.0	COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,1RR4T@1236|Gammaproteobacteria,46116@72273|Thiotrichales	72273|Thiotrichales	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD3_k127_5578806_16	398578.Daci_0538	2.368e-172	548.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,2VPBU@28216|Betaproteobacteria,4ACPA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
HKD3_k127_5578806_59	1123256.KB907942_gene39	2.096e-37	162.0	COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,1S7IY@1236|Gammaproteobacteria,1X7V3@135614|Xanthomonadales	135614|Xanthomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_5578806_10	450851.PHZ_c1911	3.066e-221	695.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,2KG5Q@204458|Caulobacterales	204458|Caulobacterales	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8
HKD3_k127_5578806_31	596154.Alide2_2989	4.807e-124	405.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2VT4Y@28216|Betaproteobacteria,4AJDN@80864|Comamonadaceae	28216|Betaproteobacteria	M	Fasciclin domain	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD3_k127_5578806_32	479434.Sthe_0848	4.715e-122	406.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi	2|Bacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	atrB	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_5578806_64	748247.AZKH_3436	3.906e-27	119.0	COG3427@1|root,COG3427@2|Bacteria,1N55Y@1224|Proteobacteria,2VTZD@28216|Betaproteobacteria,2KX5B@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD3_k127_5578806_38	224911.27354078	8.728e-90	306.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2TU05@28211|Alphaproteobacteria,3JS0Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_08580	-	-	-	-	-	-	-	-	-	-	-	Endostatin
HKD3_k127_5578806_27	522306.CAP2UW1_2783	1.407e-130	428.0	COG1502@1|root,COG1502@2|Bacteria,1RBXW@1224|Proteobacteria	1224|Proteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD3_k127_5578806_6	522306.CAP2UW1_2784	4.298e-243	766.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,1KPU9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_5578806_62	1121127.JAFA01000014_gene6619	3.379e-30	131.0	2C2X7@1|root,2ZFQR@2|Bacteria,1RCRI@1224|Proteobacteria,2W5Y5@28216|Betaproteobacteria,1K958@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_9	113395.AXAI01000005_gene4150	1.387e-231	742.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3JUS1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
HKD3_k127_5578806_70	243233.MCA0647	6.58e-14	81.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD3_k127_5578806_58	1454004.AW11_00196	2.319e-38	149.0	COG3133@1|root,COG3133@2|Bacteria,1N3A1@1224|Proteobacteria	1224|Proteobacteria	M	Outer Membrane Lipoprotein	pcp	-	-	ko:K06077	-	-	-	-	ko00000	-	-	-	Rick_17kDa_Anti
HKD3_k127_5578806_1	1304872.JAGC01000009_gene1532	0.0	1401.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MAAB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD3_k127_5578806_43	420324.KI912013_gene9358	9.396e-74	261.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,1JRS3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_5578806_48	522306.CAP2UW1_1260	3.137e-64	228.0	2EB3I@1|root,33549@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_39	522306.CAP2UW1_1259	4.25e-89	311.0	COG3900@1|root,COG3900@2|Bacteria,1RD2W@1224|Proteobacteria	1224|Proteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD3_k127_5578806_66	522306.CAP2UW1_1258	2.52e-24	109.0	2ECC0@1|root,336AD@2|Bacteria,1NH5F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5578806_56	1454004.AW11_01640	4.798e-45	188.0	28IHQ@1|root,2Z8IX@2|Bacteria,1PX3U@1224|Proteobacteria,2VWXF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
HKD3_k127_5578806_4	113395.AXAI01000007_gene1326	1.848e-282	883.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JSR7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_09220	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_5578806_54	580332.Slit_2510	1.811e-46	179.0	COG1309@1|root,COG1309@2|Bacteria,1N7CN@1224|Proteobacteria,2VX4J@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_5578806_29	640081.Dsui_2342	1.108e-126	419.0	COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,2WHE9@28216|Betaproteobacteria,2KYTU@206389|Rhodocyclales	206389|Rhodocyclales	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_3
HKD3_k127_5578806_22	640081.Dsui_2341	3.544e-142	473.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,2KXQS@206389|Rhodocyclales	206389|Rhodocyclales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_5578806_12	640081.Dsui_2340	4.285e-196	616.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,2KWV0@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD3_k127_5578806_14	864051.BurJ1DRAFT_3487	3.774e-185	591.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2VJSD@28216|Betaproteobacteria,1KK9A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD3_k127_5578806_26	864051.BurJ1DRAFT_3486	2.524e-131	426.0	COG0438@1|root,COG0438@2|Bacteria,1RB3J@1224|Proteobacteria,2VJNY@28216|Betaproteobacteria,1KN1C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD3_k127_5578806_3	926569.ANT_31250	9.754e-303	972.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD3_k127_5578806_51	1173026.Glo7428_0663	3.246e-57	205.0	COG0583@1|root,COG0583@2|Bacteria,1G0RE@1117|Cyanobacteria	1117|Cyanobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	rbcR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_5667924_3	1095769.CAHF01000023_gene593	1.291e-27	113.0	2E46A@1|root,32Z28@2|Bacteria,1N6V5@1224|Proteobacteria,2VWQU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5667924_1	258594.RPA0674	9.839e-160	532.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,3JU3K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	alcohol dehydrogenase	MA20_19250	-	1.1.1.1,1.1.1.284	ko:K00001,ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_5667924_2	864051.BurJ1DRAFT_3538	2.194e-103	349.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,1KKCR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HKD3_k127_5667924_0	748247.AZKH_4180	4.824e-171	544.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2VHD1@28216|Betaproteobacteria,2KVBD@206389|Rhodocyclales	206389|Rhodocyclales	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD3_k127_5667924_5	990285.RGCCGE502_16355	8.636e-07	54.0	COG2370@1|root,COG2370@2|Bacteria,1PPXD@1224|Proteobacteria,2V2C6@28211|Alphaproteobacteria,4BI58@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ
HKD3_k127_579563_0	204773.HEAR2918	4.839e-214	670.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,4726R@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD3_k127_579563_4	1095769.CAHF01000014_gene2985	3.516e-163	522.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,4728E@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3,OmpA
HKD3_k127_579563_29	1434929.X946_4278	3.442e-29	123.0	COG5488@1|root,COG5488@2|Bacteria,1N5Z9@1224|Proteobacteria,2VU1W@28216|Betaproteobacteria,1K6XS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
HKD3_k127_579563_19	1175306.GWL_35810	7.597e-65	237.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2VJP9@28216|Betaproteobacteria,4736A@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD3_k127_579563_23	640510.BC1001_0264	2.28e-44	173.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2VSPK@28216|Betaproteobacteria,1K0KN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD3_k127_579563_17	342113.DM82_3664	1.349e-69	252.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,1K3CQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD3_k127_579563_24	649754.HMPREF0281_00840	3.126e-44	172.0	COG1611@1|root,COG1611@2|Bacteria,2GMM1@201174|Actinobacteria,22M74@1653|Corynebacteriaceae	201174|Actinobacteria	L	Belongs to the LOG family	yvdD	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Lysine_decarbox,NUDIX
HKD3_k127_579563_10	1121035.AUCH01000005_gene170	7.612e-114	376.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,2KUAI@206389|Rhodocyclales	206389|Rhodocyclales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD3_k127_579563_28	1095769.CAHF01000014_gene3041	2.8e-34	140.0	COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,474KS@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
HKD3_k127_579563_22	375286.mma_3219	1.272e-57	204.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,4741I@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HKD3_k127_579563_25	1144319.PMI16_00135	3.009e-35	139.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2VU2J@28216|Betaproteobacteria,474TH@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HKD3_k127_579563_26	977880.RALTA_A0277	3.184e-35	140.0	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,1K7Q4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Rhodanese domain protein	glpE	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD3_k127_579563_9	1532557.JL37_22750	4.734e-123	398.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2VHEK@28216|Betaproteobacteria,3T1HS@506|Alcaligenaceae	28216|Betaproteobacteria	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD3_k127_579563_2	1000565.METUNv1_02930	1.7e-196	640.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,2KUHV@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD3_k127_579563_11	887898.HMPREF0551_2384	6.865e-107	352.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,1K0UQ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD3_k127_579563_33	935863.AWZR01000007_gene318	6.704e-07	57.0	2B59H@1|root,31Y3N@2|Bacteria,1QD30@1224|Proteobacteria,1T8Y4@1236|Gammaproteobacteria,1XBDP@135614|Xanthomonadales	135614|Xanthomonadales	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD3_k127_579563_3	287.DR97_1518	4.042e-186	605.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RR6F@1236|Gammaproteobacteria,1YFF7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD3_k127_579563_14	1286093.C266_09137	3.555e-79	276.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,2VQ4C@28216|Betaproteobacteria,1K3TI@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	slmA	-	-	ko:K05501	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	TetR_N
HKD3_k127_579563_21	977880.RALTA_A0152	2.67e-58	209.0	COG0546@1|root,COG0546@2|Bacteria,1QW9P@1224|Proteobacteria,2VRRH@28216|Betaproteobacteria,1KG6G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD3_k127_579563_7	887898.HMPREF0551_2348	5.053e-138	460.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2VIIY@28216|Betaproteobacteria,1K1QX@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD3_k127_579563_31	29581.BW37_01133	6.091e-24	112.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2VJR1@28216|Betaproteobacteria,4736R@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD3_k127_579563_27	159087.Daro_0151	1.947e-34	140.0	COG0406@1|root,COG0406@2|Bacteria,1N14H@1224|Proteobacteria,2VU12@28216|Betaproteobacteria,2KWWS@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD3_k127_579563_1	1005048.CFU_4046	1.628e-208	669.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,472CD@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD3_k127_579563_16	887898.HMPREF0551_2344	1.969e-72	263.0	COG3113@1|root,COG3113@2|Bacteria,1QX17@1224|Proteobacteria,2WH3U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HKD3_k127_579563_20	375286.mma_3206	1.751e-62	222.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VQR5@28216|Betaproteobacteria,4744B@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD3_k127_579563_5	887898.HMPREF0551_2342	1.61e-154	504.0	COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VIHH@28216|Betaproteobacteria,1K1R3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cobalamin synthesis protein cobW C-terminal domain	yjiA_1	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
HKD3_k127_579563_32	1235457.C404_23240	7.824e-23	115.0	COG0735@1|root,COG0735@2|Bacteria,1NCW6@1224|Proteobacteria,2VVWI@28216|Betaproteobacteria,1K5RU@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD3_k127_579563_6	762966.HMPREF9439_00318	8.564e-146	486.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,4PQTS@995019|Sutterellaceae	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD3_k127_579563_12	887898.HMPREF0551_2341	1.219e-95	322.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,2VJ5V@28216|Betaproteobacteria,1K2A3@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD3_k127_579563_18	596154.Alide2_4086	1.831e-66	246.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria,4ACME@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HKD3_k127_579563_8	1286093.C266_09337	6.653e-131	425.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,1JZSS@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD3_k127_579563_13	887898.HMPREF0551_2338	2.034e-86	307.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,1JZT1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	lipid A biosynthesis	htrB	-	2.3.1.241,2.3.1.242	ko:K02517,ko:K12974	ko00540,ko01100,map00540,map01100	M00060	R05146,R10906	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD3_k127_579563_15	1007105.PT7_2554	4.635e-78	271.0	COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,2VKN0@28216|Betaproteobacteria,3T1RU@506|Alcaligenaceae	28216|Betaproteobacteria	M	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA	htrB_2	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD3_k127_579563_30	1031711.RSPO_c03230	4.159e-26	117.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,1K2M9@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD3_k127_5883349_21	1217656.F964_04122	1.28e-59	209.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,3NITF@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iPC815.YPO3971,iSDY_1059.SDY_1514,iYL1228.KPN_01210,iZ_1308.Z2793	ELFV_dehydrog,ELFV_dehydrog_N
HKD3_k127_5883349_23	1123504.JQKD01000036_gene3180	1.203e-27	115.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,4AEZ5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD3_k127_5883349_15	864073.HFRIS_014514	1.405e-82	284.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,4761R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD3_k127_5883349_1	94624.Bpet4847	0.0	1002.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,3T1K0@506|Alcaligenaceae	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD3_k127_5883349_22	1217718.ALOU01000002_gene4724	2.918e-58	213.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,1K6ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HKD3_k127_5883349_13	887898.HMPREF0551_1839	1.222e-92	317.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,1K01Z@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD3_k127_5883349_10	264198.Reut_A0444	2.188e-114	383.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,1K1ZM@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD3_k127_5883349_14	426114.THI_0375	2.079e-83	284.0	2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2WGPR@28216|Betaproteobacteria,1KPCW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
HKD3_k127_5883349_0	62928.azo0445	0.0	1072.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria,2KX7T@206389|Rhodocyclales	206389|Rhodocyclales	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD3_k127_5883349_4	522306.CAP2UW1_2653	8.791e-232	730.0	COG3961@1|root,COG3961@2|Bacteria,1MW2F@1224|Proteobacteria,2VIQN@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the TPP enzyme family	ipdC	-	4.1.1.74	ko:K04103	ko00380,ko01100,map00380,map01100	-	R01974	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_5883349_20	1157708.KB907463_gene787	3.011e-60	216.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2VRFD@28216|Betaproteobacteria,4ADV8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD3_k127_5883349_12	1211115.ALIQ01000196_gene65	1.566e-100	344.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria	1224|Proteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD3_k127_5883349_5	358220.C380_11740	1.17e-207	655.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2VJ1E@28216|Betaproteobacteria,4ACV2@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular liganD-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_5883349_8	358220.C380_11745	2.303e-146	470.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2VHAJ@28216|Betaproteobacteria,4AB5H@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5883349_9	1157708.KB907459_gene2135	2.323e-140	468.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,2VIFR@28216|Betaproteobacteria,4ADC4@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5883349_19	1123355.JHYO01000002_gene1287	9.95e-63	224.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,36Z81@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD3_k127_5883349_11	1157708.KB907459_gene2137	1.411e-101	347.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VKKX@28216|Betaproteobacteria,4AB5R@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_5883349_6	477184.KYC_01829	6.162e-185	587.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VJNE@28216|Betaproteobacteria,3T5YB@506|Alcaligenaceae	28216|Betaproteobacteria	C	3-isopropylmalate dehydratase large subunit	leuC1	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD3_k127_5883349_18	123899.JPQP01000022_gene3491	2.538e-70	242.0	COG0066@1|root,COG0066@2|Bacteria,1RBRQ@1224|Proteobacteria,2VVIK@28216|Betaproteobacteria,3T7DS@506|Alcaligenaceae	28216|Betaproteobacteria	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD3_k127_5883349_3	477184.KYC_01819	1.216e-250	794.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2VITF@28216|Betaproteobacteria	28216|Betaproteobacteria	EQ	Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD3_k127_5883349_2	543728.Vapar_0803	5.794e-263	855.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2VJUZ@28216|Betaproteobacteria,4AAHY@80864|Comamonadaceae	28216|Betaproteobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD3_k127_5883349_16	543728.Vapar_0804	2.155e-79	271.0	COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,2VPE8@28216|Betaproteobacteria,4ADSG@80864|Comamonadaceae	28216|Betaproteobacteria	Q	isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD3_k127_5883349_7	358220.C380_11795	2.94e-171	551.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2VINH@28216|Betaproteobacteria,4AB8Y@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
HKD3_k127_5883349_17	757424.Hsero_0323	2.018e-70	244.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VN7W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_5969978_7	388051.AUFE01000028_gene5013	5.039e-60	213.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,1K2HM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD3_k127_5969978_8	580332.Slit_2726	2.886e-14	80.0	COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,44W2Z@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
HKD3_k127_5969978_0	1095769.CAHF01000014_gene2914	4.708e-248	785.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria,472P4@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD3_k127_5969978_6	93220.LV28_11475	1.445e-130	436.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2WGFS@28216|Betaproteobacteria,1K2YV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_5969978_4	1144319.PMI16_01544	1.191e-141	466.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,4727K@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10,6.3.2.13	ko:K01929,ko:K15792	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R02788,R04573,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_5969978_1	887898.HMPREF0551_1813	1.485e-194	635.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,1K01P@119060|Burkholderiaceae	28216|Betaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD3_k127_5969978_3	859657.RPSI07_0661	7.487e-159	534.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,1K0RE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD3_k127_5969978_2	977880.RALTA_A2730	8.435e-165	551.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2VI5Q@28216|Betaproteobacteria,1K0M1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD3_k127_5969978_5	76114.ebA1444	2.417e-137	468.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2VH32@28216|Betaproteobacteria,2KVGS@206389|Rhodocyclales	206389|Rhodocyclales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD3_k127_5969978_9	1123367.C666_10795	0.0004583	52.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,2KVFZ@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_6045703_30	1211114.ALIP01000077_gene2963	1.38e-15	76.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_6045703_14	713586.KB900536_gene1447	2.026e-80	284.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD3_k127_6045703_1	1238182.C882_0257	0.0	1069.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPRP@204441|Rhodospirillales	204441|Rhodospirillales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_6045703_13	269482.Bcep1808_1237	1.429e-82	284.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,1K069@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_6045703_7	887898.HMPREF0551_1126	1.114e-137	449.0	28I8W@1|root,2Z8BP@2|Bacteria,1N0SC@1224|Proteobacteria,2VK0J@28216|Betaproteobacteria,1K1F1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2863
HKD3_k127_6045703_29	1268622.AVS7_01216	6.172e-16	90.0	COG0526@1|root,COG0526@2|Bacteria,1NBTN@1224|Proteobacteria,2VW6S@28216|Betaproteobacteria,4AF60@80864|Comamonadaceae	28216|Betaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HKD3_k127_6045703_19	497321.C664_09933	7.698e-45	168.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,2KWNG@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
HKD3_k127_6045703_20	395495.Lcho_3781	2.11e-43	170.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,1KMCW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM Sulphur oxidation protein SoxZ	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
HKD3_k127_6045703_12	93220.LV28_13545	1.523e-83	289.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,1K2BG@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	soxA	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
HKD3_k127_6045703_16	204773.HEAR1194	3.372e-57	207.0	COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2VP4W@28216|Betaproteobacteria,475FZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome c	soxX	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HKD3_k127_6045703_2	93220.LV28_13530	3.36e-276	871.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	soxB	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
HKD3_k127_6045703_23	1458427.BAWN01000007_gene500	3.48e-40	171.0	COG3193@1|root,COG3193@2|Bacteria,1REF5@1224|Proteobacteria,2VT55@28216|Betaproteobacteria,4AEYR@80864|Comamonadaceae	28216|Betaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD3_k127_6045703_8	1163617.SCD_n00859	7.914e-115	383.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_6045703_28	1123392.AQWL01000005_gene3027	1.093e-20	103.0	COG0589@1|root,COG0589@2|Bacteria,1PE08@1224|Proteobacteria,2VNHV@28216|Betaproteobacteria	28216|Betaproteobacteria	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_6045703_3	62928.azo3057	2.846e-268	830.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,2KVI4@206389|Rhodocyclales	206389|Rhodocyclales	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HKD3_k127_6045703_26	1123392.AQWL01000005_gene2958	4.43e-28	117.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2VUA0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD3_k127_6045703_11	85643.Tmz1t_1388	1.889e-85	297.0	COG4243@1|root,COG4243@2|Bacteria,1MW9C@1224|Proteobacteria,2VPG2@28216|Betaproteobacteria,2KU9P@206389|Rhodocyclales	206389|Rhodocyclales	S	Vitamin k epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6045703_24	1244869.H261_09879	1.731e-39	152.0	COG1959@1|root,COG1959@2|Bacteria,1PZ79@1224|Proteobacteria,2UCUA@28211|Alphaproteobacteria,2JTF5@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD3_k127_6045703_22	1150469.RSPPHO_01831	2.032e-40	157.0	COG0454@1|root,COG0456@2|Bacteria,1N43K@1224|Proteobacteria,2UDB6@28211|Alphaproteobacteria,2JTG2@204441|Rhodospirillales	204441|Rhodospirillales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_6045703_21	1380394.JADL01000002_gene1592	5.144e-42	163.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria,2JUEU@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6045703_0	85643.Tmz1t_2959	0.0	1272.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.5.1,3.1.2.25	ko:K18361	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HKD3_k127_6045703_10	1244869.H261_16276	9.124e-108	353.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2TTE2@28211|Alphaproteobacteria,2JRY6@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0437 Fe-S-cluster-containing hydrogenase components 1	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
HKD3_k127_6045703_18	62928.azo1948	5.101e-45	182.0	COG3302@1|root,COG3302@2|Bacteria,1N8SU@1224|Proteobacteria,2WGE7@28216|Betaproteobacteria,2M04N@206389|Rhodocyclales	206389|Rhodocyclales	S	DMSO reductase anchor subunit (DmsC)	-	-	-	ko:K18363	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001	-	-	-	DmsC
HKD3_k127_6045703_6	1120956.JHZK01000027_gene1178	3.444e-183	595.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,1JPTQ@119043|Rhodobiaceae	28211|Alphaproteobacteria	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD3_k127_6045703_17	652103.Rpdx1_3435	4.243e-54	208.0	COG3278@1|root,COG3278@2|Bacteria,1PU2D@1224|Proteobacteria,2U5ID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the heme-copper respiratory oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6045703_27	652103.Rpdx1_3434	1.513e-23	106.0	2E0AX@1|root,32VY8@2|Bacteria,1N21Q@1224|Proteobacteria,2UECC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_6045703_15	1244869.H261_21688	2.376e-62	228.0	COG0454@1|root,COG0456@2|Bacteria,1RGZ2@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_6045703_25	316057.RPD_1533	9.139e-33	130.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2UG0Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD3_k127_6045703_9	1244869.H261_03123	4.527e-110	363.0	COG1924@1|root,COG1924@2|Bacteria,1MY0N@1224|Proteobacteria,2U4V9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Benzoyl-CoA reductase subunit	-	-	1.3.7.8	ko:K04115	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
HKD3_k127_6045703_5	1187851.A33M_3198	6.888e-185	587.0	COG1924@1|root,COG1924@2|Bacteria,1R411@1224|Proteobacteria,2U1DN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Benzoyl-CoA reductase subunit	-	-	1.3.7.8	ko:K04114	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	BcrAD_BadFG
HKD3_k127_6045703_4	1187851.A33M_3197	5.74e-199	624.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD3_k127_6076764_21	987059.RBXJA2T_13054	1.517e-28	115.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Cold shock protein	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD3_k127_6076764_4	1195246.AGRI_05412	1.075e-113	374.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,46CN8@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K21703,ko:K21711	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_6076764_1	1195246.AGRI_05407	1.882e-214	678.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,1S1TG@1236|Gammaproteobacteria,4657D@72275|Alteromonadaceae	1236|Gammaproteobacteria	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD3_k127_6076764_8	452637.Oter_2574	3.061e-94	318.0	COG0288@1|root,COG0288@2|Bacteria,46S9J@74201|Verrucomicrobia,3K7VC@414999|Opitutae	414999|Opitutae	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD3_k127_6076764_9	614083.AWQR01000035_gene3612	7.43e-90	306.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2VMQN@28216|Betaproteobacteria,4ADD5@80864|Comamonadaceae	28216|Betaproteobacteria	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
HKD3_k127_6076764_11	358220.C380_09530	4.772e-83	297.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,4AEPM@80864|Comamonadaceae	28216|Betaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD3_k127_6076764_13	358220.C380_09535	6e-71	244.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,2VU1H@28216|Betaproteobacteria,4AES2@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihaem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
HKD3_k127_6076764_17	358220.C380_09540	1.261e-52	192.0	COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,2VU18@28216|Betaproteobacteria,4AF6R@80864|Comamonadaceae	28216|Betaproteobacteria	C	Domain of unknown function (DUF1924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1924
HKD3_k127_6076764_22	1123255.JHYS01000020_gene2728	2.136e-23	103.0	COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,2VWE0@28216|Betaproteobacteria,4AFJM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase propeptide and YPEB domain	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
HKD3_k127_6076764_6	864051.BurJ1DRAFT_3555	6.499e-112	369.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,1KJQ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_6076764_2	1123255.JHYS01000020_gene2730	1.293e-151	498.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2VIZI@28216|Betaproteobacteria,4AAQV@80864|Comamonadaceae	28216|Betaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	phoQ	-	2.7.13.3	ko:K07637	ko01503,ko02020,map01503,map02020	M00444,M00709,M00721,M00723,M00724,M00744	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c
HKD3_k127_6076764_19	338969.Rfer_2535	1.201e-49	182.0	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,2VSDZ@28216|Betaproteobacteria,4AEIQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD3_k127_6076764_3	1158292.JPOE01000002_gene3441	1.581e-116	393.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VICP@28216|Betaproteobacteria,1KM74@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_6076764_0	314230.DSM3645_07910	9.077e-236	738.0	COG5361@1|root,COG5361@2|Bacteria,2IZB8@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254,Neur_chan_LBD,Neur_chan_memb
HKD3_k127_6076764_7	864073.HFRIS_001694	5.559e-103	350.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,472ET@75682|Oxalobacteraceae	28216|Betaproteobacteria	CH	Squalene epoxidase	ubiF	-	-	ko:K03184,ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R06146,R08773,R08775	RC01254,RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD3_k127_6076764_15	887898.HMPREF0551_2646	4.638e-61	220.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,1K1N6@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbC	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
HKD3_k127_6076764_10	887898.HMPREF0551_2647	4.97e-86	297.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,1K0GP@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM MltA domain protein	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HKD3_k127_6076764_20	640081.Dsui_1869	3.194e-30	123.0	2DNV8@1|root,32ZAX@2|Bacteria,1R3MW@1224|Proteobacteria,2VWAR@28216|Betaproteobacteria,2KWYT@206389|Rhodocyclales	206389|Rhodocyclales	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD3_k127_6076764_18	859657.RPSI07_0626	2.81e-52	190.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1K7XM@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HKD3_k127_6076764_5	795666.MW7_2926	5.716e-112	366.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1K37J@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD3_k127_6076764_14	511.JT27_02860	6.333e-66	243.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2VIZ6@28216|Betaproteobacteria,3T3KD@506|Alcaligenaceae	28216|Betaproteobacteria	G	Phosphoglycolate phosphatase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD3_k127_6076764_12	1286631.X805_17020	6.566e-80	271.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,1KIVZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD3_k127_6085215_1	864051.BurJ1DRAFT_3335	1.349e-157	501.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,2VPBV@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD3_k127_6085215_0	864051.BurJ1DRAFT_3336	1.279e-240	749.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,2VPWJ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	sulfite reductase, dissimilatory-type alpha subunit	-	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD3_k127_6085215_6	1485544.JQKP01000005_gene311	1.58e-14	87.0	2EMP6@1|root,33FBM@2|Bacteria,1NGBE@1224|Proteobacteria,2VYCB@28216|Betaproteobacteria,44WK7@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6085215_5	580332.Slit_1688	3.598e-37	150.0	2CARE@1|root,2Z8Q5@2|Bacteria,1R7S8@1224|Proteobacteria,2VVIY@28216|Betaproteobacteria,44WHH@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Cas6 Crispr	-	-	-	-	-	-	-	-	-	-	-	-	Cas6
HKD3_k127_6085215_3	580332.Slit_1690	3.32e-53	192.0	COG0425@1|root,COG0425@2|Bacteria,1PX23@1224|Proteobacteria,2WCJT@28216|Betaproteobacteria,44W8S@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
HKD3_k127_6085215_4	1485544.JQKP01000005_gene307	3.415e-39	166.0	28IET@1|root,2Z8GT@2|Bacteria,1R4FQ@1224|Proteobacteria,2VUGA@28216|Betaproteobacteria,44W4S@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6085215_2	1485544.JQKP01000005_gene306	1.507e-100	341.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,2VIG6@28216|Betaproteobacteria,44W7U@713636|Nitrosomonadales	28216|Betaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD3_k127_6103446_3	1110502.TMO_3350	1.135e-102	346.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2JR9C@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD3_k127_6103446_12	1265502.KB905969_gene1247	4.84e-29	117.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD3_k127_6103446_10	1123253.AUBD01000001_gene1932	1.528e-40	151.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1X9BX@135614|Xanthomonadales	135614|Xanthomonadales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HKD3_k127_6103446_13	1123253.AUBD01000001_gene1932	8.631e-21	93.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1X9BX@135614|Xanthomonadales	135614|Xanthomonadales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HKD3_k127_6103446_18	1123253.AUBD01000001_gene1932	3.317e-05	47.0	COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1X9BX@135614|Xanthomonadales	135614|Xanthomonadales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HKD3_k127_6103446_17	522306.CAP2UW1_3856	1.145e-05	50.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,2WFCS@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
HKD3_k127_6103446_19	1397528.Q671_14960	0.0004732	49.0	COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XS39@135619|Oceanospirillales	135619|Oceanospirillales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
HKD3_k127_6103446_1	1121946.AUAX01000021_gene8043	8.132e-105	352.0	COG1073@1|root,COG1073@2|Bacteria,2GNST@201174|Actinobacteria,4DG09@85008|Micromonosporales	201174|Actinobacteria	S	Alpha/beta hydrolase of unknown function (DUF1100)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DUF1100,Peptidase_S9
HKD3_k127_6103446_6	1157708.KB907454_gene2989	1.464e-66	240.0	COG3181@1|root,COG3181@2|Bacteria,1NWBV@1224|Proteobacteria,2W2XU@28216|Betaproteobacteria,4AHX6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6103446_7	392499.Swit_1679	1.497e-66	250.0	COG4689@1|root,COG4689@2|Bacteria,1MYK7@1224|Proteobacteria,2UNI9@28211|Alphaproteobacteria,2KAR8@204457|Sphingomonadales	204457|Sphingomonadales	Q	Acetoacetate decarboxylase (ADC)	-	-	-	-	-	-	-	-	-	-	-	-	ADC
HKD3_k127_6103446_8	398578.Daci_5297	1.366e-54	205.0	COG0662@1|root,COG0662@2|Bacteria,1QU63@1224|Proteobacteria,2VS9Z@28216|Betaproteobacteria,4AE2Q@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_6103446_9	1157708.KB907454_gene2988	2.467e-41	169.0	COG1309@1|root,COG1309@2|Bacteria,1R6X5@1224|Proteobacteria,2VMQ6@28216|Betaproteobacteria,4ACS7@80864|Comamonadaceae	28216|Betaproteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_6103446_16	1245475.ANAE01000094_gene4350	6.352e-07	61.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_6103446_2	243365.CV_0363	1.239e-103	351.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K11750	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_6,DUF1100
HKD3_k127_6103446_11	28229.ND2E_0750	2.154e-35	152.0	COG1917@1|root,COG1917@2|Bacteria,1R5IE@1224|Proteobacteria,1S3I4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_6103446_4	391735.Veis_4798	4.597e-93	324.0	COG3181@1|root,COG3181@2|Bacteria,1RDH7@1224|Proteobacteria,2VQ5S@28216|Betaproteobacteria,4AE8D@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6103446_0	1442599.JAAN01000051_gene2675	5.612e-160	509.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1X44U@135614|Xanthomonadales	135614|Xanthomonadales	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD3_k127_6103446_15	325777.GW15_0201295	9.769e-11	66.0	COG3677@1|root,COG3677@2|Bacteria	2|Bacteria	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
HKD3_k127_6103446_14	82995.CR62_13015	1.502e-16	85.0	COG2259@1|root,COG2259@2|Bacteria,1RHKP@1224|Proteobacteria,1SC26@1236|Gammaproteobacteria,40532@613|Serratia	1236|Gammaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD3_k127_6103446_5	1502851.FG93_02348	1.468e-77	264.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TT4X@28211|Alphaproteobacteria,3JUZ1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD3_k127_6174530_14	414684.RC1_0997	8.866e-105	346.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPGU@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
HKD3_k127_6174530_23	640510.BC1001_1119	1.031e-16	88.0	COG3235@1|root,COG3235@2|Bacteria,1RDMZ@1224|Proteobacteria,2VX9R@28216|Betaproteobacteria,1JZYJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
HKD3_k127_6174530_12	887898.HMPREF0551_2038	1.738e-108	365.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,1KFI8@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD3_k127_6174530_13	1210884.HG799469_gene14124	5.303e-107	356.0	COG2326@1|root,COG2326@2|Bacteria,2IYWN@203682|Planctomycetes	203682|Planctomycetes	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD3_k127_6174530_5	1157708.KB907453_gene4189	3.832e-160	519.0	COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,4AAK9@80864|Comamonadaceae	28216|Betaproteobacteria	E	TIGRFAM amidase, hydantoinase carbamoylase family	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD3_k127_6174530_8	1223521.BBJX01000002_gene2781	1.137e-121	408.0	28MAA@1|root,2ZAP0@2|Bacteria,1R5EZ@1224|Proteobacteria,2VNTE@28216|Betaproteobacteria,4AHBF@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6174530_3	1380394.JADL01000002_gene1189	1.3e-235	746.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,2JQQU@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_6174530_4	1366050.N234_20455	1.124e-232	736.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K2NR@119060|Burkholderiaceae	28216|Betaproteobacteria	E	(GMC) oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_6174530_6	398578.Daci_3992	1.653e-142	463.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2VIKG@28216|Betaproteobacteria,4AC8S@80864|Comamonadaceae	28216|Betaproteobacteria	S	Fad dependent oxidoreductase	lhgO	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO
HKD3_k127_6174530_22	1218352.B597_006605	5.645e-22	97.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,1SF0T@1236|Gammaproteobacteria,1Z3J3@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD3_k127_6174530_18	395495.Lcho_0203	1.198e-67	240.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,1KKKS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	regulatory protein Crp	nnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_6174530_2	257310.BB0001	6.448e-320	1002.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,3T2SX@506|Alcaligenaceae	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD3_k127_6174530_19	342113.DM82_3132	4.492e-46	177.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,1K0RU@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD3_k127_6174530_7	1502852.FG94_04768	1.194e-126	411.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,473F2@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD3_k127_6174530_15	667632.KB890176_gene4604	3.661e-100	336.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,1K08J@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD3_k127_6174530_9	1304883.KI912532_gene391	1.516e-113	382.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2VIDH@28216|Betaproteobacteria,2KU81@206389|Rhodocyclales	206389|Rhodocyclales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD3_k127_6174530_0	522306.CAP2UW1_2665	0.0	1594.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQF1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_6174530_21	522306.CAP2UW1_2961	4.161e-28	127.0	COG2010@1|root,COG2010@2|Bacteria,1NAGW@1224|Proteobacteria,2VW71@28216|Betaproteobacteria	28216|Betaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_6174530_10	1265502.KB905946_gene1118	1.538e-113	385.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VR34@28216|Betaproteobacteria,4AA2R@80864|Comamonadaceae	28216|Betaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD3_k127_6174530_16	535289.Dtpsy_0431	6.999e-89	304.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2VQZD@28216|Betaproteobacteria,4AAKD@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase
HKD3_k127_6174530_11	535289.Dtpsy_0430	8.258e-112	376.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2VK31@28216|Betaproteobacteria,4A9JT@80864|Comamonadaceae	28216|Betaproteobacteria	C	nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
HKD3_k127_6174530_17	1265502.KB905946_gene1121	2.992e-80	275.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2VQI7@28216|Betaproteobacteria,4ACPP@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM nitrate reductase molybdenum cofactor assembly chaperone	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
HKD3_k127_6174530_1	1000565.METUNv1_02355	3.02e-321	987.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,2KVF3@206389|Rhodocyclales	206389|Rhodocyclales	C	Respiratory nitrate reductase beta C-terminal	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
HKD3_k127_6174530_20	504832.OCAR_5043	4.786e-30	119.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2TQJW@28211|Alphaproteobacteria,3JVHG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
HKD3_k127_6179736_27	1217718.ALOU01000082_gene3007	6.594e-27	110.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,1K119@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD3_k127_6179736_24	887898.HMPREF0551_0959	1.289e-41	169.0	COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,1K36F@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	-	-	-	-	-	-	-	-	-	ZipA_C
HKD3_k127_6179736_3	305700.B447_05193	1.19e-245	782.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,2KUWJ@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD3_k127_6179736_17	748247.AZKH_2797	7.511e-89	327.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2VJQQ@28216|Betaproteobacteria,2KV4J@206389|Rhodocyclales	206389|Rhodocyclales	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD3_k127_6179736_13	296591.Bpro_4167	2.436e-109	375.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2VH3E@28216|Betaproteobacteria,4AJ9Z@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD3_k127_6179736_1	1095769.CAHF01000011_gene2241	0.0	1067.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,472BY@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
HKD3_k127_6179736_6	323848.Nmul_A2632	1.764e-140	451.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,371P4@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Methionine aminopeptidase	map	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD3_k127_6179736_8	887898.HMPREF0551_0953	3.643e-125	407.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,1K1AU@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD3_k127_6179736_5	305700.B447_05233	8.24e-147	469.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,2KU95@206389|Rhodocyclales	206389|Rhodocyclales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD3_k127_6179736_12	1005048.CFU_1333	1.125e-115	381.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,473A3@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD3_k127_6179736_18	402626.Rpic_1281	3.374e-81	275.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,1JZWS@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD3_k127_6179736_11	94624.Bpet2531	5.633e-116	378.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,3T293@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD3_k127_6179736_21	1038869.AXAN01000037_gene1580	2.499e-59	215.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,1K18N@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD3_k127_6179736_7	1123368.AUIS01000001_gene2042	1.462e-135	443.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,2NC7Y@225057|Acidithiobacillales	225057|Acidithiobacillales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD3_k127_6179736_9	264198.Reut_A1874	1.641e-123	427.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1JZSU@119060|Burkholderiaceae	28216|Betaproteobacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD3_k127_6179736_2	887898.HMPREF0551_0945	4.606e-279	902.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,1JZZ1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD3_k127_6179736_23	1217718.ALOU01000007_gene1355	1.773e-52	192.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,1K13G@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the skp family	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD3_k127_6179736_16	204773.HEAR1345	2.136e-95	327.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,473BV@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD3_k127_6179736_22	887898.HMPREF0551_0942	6.218e-55	212.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,1JZUQ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD3_k127_6179736_15	887898.HMPREF0551_0941	2.691e-106	357.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1K293@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD3_k127_6179736_14	887898.HMPREF0551_0940	4.888e-108	374.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,1K18S@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD3_k127_6179736_20	269482.Bcep1808_1911	2.978e-67	235.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,1K02A@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD3_k127_6179736_19	1095769.CAHF01000011_gene2224	9.247e-70	254.0	COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,4736F@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	SpoU rRNA Methylase family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
HKD3_k127_6179736_10	1144319.PMI16_00348	1.544e-119	394.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,472KF@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	ydiA	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD3_k127_6179736_0	887898.HMPREF0551_0936	0.0	1273.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,1K0K1@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD3_k127_6179736_4	1095769.CAHF01000013_gene3205	5.96e-171	545.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,472XP@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport system, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_6179736_25	93220.LV28_01065	1.288e-29	123.0	COG1585@1|root,COG1585@2|Bacteria,1N474@1224|Proteobacteria,2VWDX@28216|Betaproteobacteria,1K7AI@119060|Burkholderiaceae	28216|Betaproteobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HKD3_k127_6179736_26	1424334.W822_14375	9.454e-29	117.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,3T1QY@506|Alcaligenaceae	28216|Betaproteobacteria	O	Membrane protease subunits, stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
HKD3_k127_6189835_1	290397.Adeh_2791	0.0	1078.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD3_k127_6189835_3	290397.Adeh_2791	1.032e-78	293.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD3_k127_6189835_0	595460.RRSWK_03757	0.0	1594.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_6189835_2	595460.RRSWK_03756	1.942e-105	365.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_6189835_4	85643.Tmz1t_2947	7.552e-12	68.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria	1224|Proteobacteria	C	Ferredoxin	fdxB	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4
HKD3_k127_6219629_11	1121004.ATVC01000028_gene120	2.024e-81	276.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2WH7R@28216|Betaproteobacteria	28216|Betaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K12536	ko02010,map02010	M00328	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.110	-	-	ABC_membrane,ABC_tran
HKD3_k127_6219629_3	946483.Cenrod_2295	1.82e-139	457.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,4AA5Y@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K02022,ko:K12537,ko:K16300	-	M00328,M00571	-	-	ko00000,ko00002,ko02000,ko02044	8.A.1,8.A.1.3.3	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD3_k127_6219629_9	522306.CAP2UW1_2828	1.397e-93	323.0	COG1538@1|root,COG1538@2|Bacteria,1Q498@1224|Proteobacteria,2VQ20@28216|Betaproteobacteria	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12538	-	M00328	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17.1	-	-	OEP
HKD3_k127_6219629_1	1217718.ALOU01000069_gene4823	5.801e-211	666.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,1K10P@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD3_k127_6219629_8	204669.Acid345_3314	1.557e-99	357.0	COG0578@1|root,COG0578@2|Bacteria,3Y2YF@57723|Acidobacteria,2JI40@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD3_k127_6219629_12	1123354.AUDR01000013_gene530	1.174e-76	274.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VPK7@28216|Betaproteobacteria	28216|Betaproteobacteria	M	lipopolysaccharide heptosyltransferase I	rfaC	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD3_k127_6219629_4	342113.DM82_2325	2.763e-131	433.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,2VI67@28216|Betaproteobacteria,1JZSQ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	transferase	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
HKD3_k127_6219629_20	1458357.BG58_39730	8.274e-28	114.0	COG2336@1|root,COG2336@2|Bacteria,1NFRR@1224|Proteobacteria,2W4U5@28216|Betaproteobacteria,1K973@119060|Burkholderiaceae	28216|Betaproteobacteria	T	antitoxin	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HKD3_k127_6219629_17	472759.Nhal_2727	4.264e-40	151.0	COG2337@1|root,COG2337@2|Bacteria,1PVJ4@1224|Proteobacteria,1T93S@1236|Gammaproteobacteria,1X1KI@135613|Chromatiales	135613|Chromatiales	L	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD3_k127_6219629_6	1095769.CAHF01000013_gene3405	1.422e-119	404.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2VHG1@28216|Betaproteobacteria,473DE@75682|Oxalobacteraceae	28216|Betaproteobacteria	MU	TIGRFAM type I secretion outer membrane protein, TolC family	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD3_k127_6219629_13	1304883.KI912532_gene1094	8.523e-75	257.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,2KUMH@206389|Rhodocyclales	206389|Rhodocyclales	O	protein-L-isoaspartate(D-aspartate) O-methyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD3_k127_6219629_0	1266925.JHVX01000001_gene2643	0.0	1173.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,372VV@32003|Nitrosomonadales	28216|Betaproteobacteria	V	AcrB/AcrD/AcrF family	nolG	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD3_k127_6219629_10	388051.AUFE01000005_gene1000	1.759e-88	315.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,1K50V@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	macA	-	-	ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_6219629_15	1349767.GJA_455	1.358e-59	231.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2VK6A@28216|Betaproteobacteria,4743P@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_11,TetR_N
HKD3_k127_6219629_16	1122604.JONR01000027_gene3045	1.542e-41	166.0	COG2199@1|root,COG5002@1|root,COG3706@2|Bacteria,COG5002@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,1X6MM@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,GGDEF
HKD3_k127_6219629_18	358220.C380_00450	3.842e-31	138.0	COG0727@1|root,32S46@2|Bacteria,1MZCU@1224|Proteobacteria,2VU00@28216|Betaproteobacteria,4AF7Z@80864|Comamonadaceae	28216|Betaproteobacteria	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD3_k127_6219629_5	887898.HMPREF0551_0074	1.789e-120	392.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,1K33P@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD3_k127_6219629_7	94624.Bpet4321	7.176e-101	334.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,3T1QF@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD3_k127_6219629_19	40571.JOEA01000001_gene5236	3.172e-29	125.0	COG1764@1|root,COG1764@2|Bacteria,2IHT2@201174|Actinobacteria,4E470@85010|Pseudonocardiales	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_6219629_22	525897.Dbac_1087	9.26e-21	100.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6219629_23	525897.Dbac_1088	4.792e-10	65.0	2ADPE@1|root,313EG@2|Bacteria,1NEWZ@1224|Proteobacteria,42V0P@68525|delta/epsilon subdivisions,2WSFD@28221|Deltaproteobacteria,2MFC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HKD3_k127_6219629_14	243231.GSU1710	1.698e-61	233.0	COG0582@1|root,COG0582@2|Bacteria,1REKP@1224|Proteobacteria,42S9N@68525|delta/epsilon subdivisions,2WNI9@28221|Deltaproteobacteria,43UXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD3_k127_6219629_21	1042375.AFPL01000022_gene2678	5.927e-25	118.0	COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,1RS88@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD3_k127_6219629_2	1304885.AUEY01000002_gene350	8.684e-173	550.0	COG3119@1|root,COG3119@2|Bacteria,1PFYE@1224|Proteobacteria,43A2J@68525|delta/epsilon subdivisions,2WQC7@28221|Deltaproteobacteria,2MNWS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD3_k127_6281999_11	296591.Bpro_5286	6.922e-103	340.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VKM9@28216|Betaproteobacteria,4AGEY@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_6281999_13	296591.Bpro_5293	1.095e-74	264.0	COG1309@1|root,COG1309@2|Bacteria,1PET3@1224|Proteobacteria,2VNNM@28216|Betaproteobacteria,4A9ZA@80864|Comamonadaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_6281999_8	1123504.JQKD01000004_gene5032	1.687e-133	445.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2VJ36@28216|Betaproteobacteria,4AHAU@80864|Comamonadaceae	28216|Betaproteobacteria	H	Enoyl-CoA hydratase/isomerase	-	-	-	ko:K07536	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05592	RC01429	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_6281999_9	296591.Bpro_5292	2.419e-129	417.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VTA7@28216|Betaproteobacteria,4AHEH@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_6281999_1	296591.Bpro_5274	1.435e-292	912.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VIW3@28216|Betaproteobacteria,4ABSX@80864|Comamonadaceae	28216|Betaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD3_k127_6281999_15	1123504.JQKD01000004_gene4988	3.259e-57	208.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2VMC8@28216|Betaproteobacteria,4AE6A@80864|Comamonadaceae	28216|Betaproteobacteria	C	HpcH/HpaI aldolase/citrate lyase family	citE	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_6281999_7	742159.HMPREF0004_2770	5.386e-143	461.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2VK16@28216|Betaproteobacteria,3T4EY@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
HKD3_k127_6281999_5	1122604.JONR01000048_gene1004	3.065e-194	638.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X3IG@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_6281999_2	296591.Bpro_5270	8.611e-285	889.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VMI6@28216|Betaproteobacteria,4AGPU@80864|Comamonadaceae	28216|Betaproteobacteria	I	Biotin carboxylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD3_k127_6281999_0	296591.Bpro_5271	9.511e-304	950.0	COG4799@1|root,COG4799@2|Bacteria,1NAIK@1224|Proteobacteria,2VPBH@28216|Betaproteobacteria,4ABWR@80864|Comamonadaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD3_k127_6281999_12	1123504.JQKD01000004_gene5122	9.194e-100	353.0	COG1024@1|root,COG1024@2|Bacteria,1NM88@1224|Proteobacteria,2VKKC@28216|Betaproteobacteria,4ACZQ@80864|Comamonadaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_6281999_4	296591.Bpro_5273	1.156e-205	645.0	COG1960@1|root,COG1960@2|Bacteria,1MUUX@1224|Proteobacteria,2VH36@28216|Betaproteobacteria,4ACW7@80864|Comamonadaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	badJ	-	-	ko:K04117	ko00362,ko01120,map00362,map01120	M00540	R05619	RC02035	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_6281999_16	1123392.AQWL01000003_gene277	1.143e-56	206.0	COG0778@1|root,COG0778@2|Bacteria,1Q0ZY@1224|Proteobacteria,2WAFT@28216|Betaproteobacteria,1KSUE@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_6281999_10	883078.HMPREF9695_00181	5.465e-112	375.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2U0E0@28211|Alphaproteobacteria,3JS2D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	MA20_27655	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_6281999_18	1129794.C427_1788	7.71e-33	132.0	COG0702@1|root,COG0702@2|Bacteria,1N1C0@1224|Proteobacteria,1S9WS@1236|Gammaproteobacteria,46BPE@72275|Alteromonadaceae	1236|Gammaproteobacteria	GM	Complex I intermediate-associated protein 30 (CIA30)	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
HKD3_k127_6281999_6	1038859.AXAU01000019_gene4817	3.33e-191	612.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_6281999_14	1254432.SCE1572_11440	1.152e-63	228.0	COG2267@1|root,COG2267@2|Bacteria,1Q416@1224|Proteobacteria,439UI@68525|delta/epsilon subdivisions,2X587@28221|Deltaproteobacteria,2Z092@29|Myxococcales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD3_k127_6281999_3	1384056.N787_05595	6.564e-207	657.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,1X5MV@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD3_k127_6281999_17	1132855.KB913035_gene2195	1.86e-56	208.0	COG0847@1|root,COG0847@2|Bacteria,1MXM2@1224|Proteobacteria,2VXP5@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_6283956_4	522306.CAP2UW1_2891	1.752e-59	219.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VIN1@28216|Betaproteobacteria,1KR64@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	ET	PFAM extracellular solute-binding protein family 3	aapJ	-	-	ko:K02030,ko:K09969,ko:K10001	ko02010,ko02020,map02010,map02020	M00230,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
HKD3_k127_6283956_5	1177179.A11A3_04305	8.399e-44	164.0	COG5470@1|root,COG5470@2|Bacteria,1MWI7@1224|Proteobacteria,1SAVX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_6283956_6	522306.CAP2UW1_3859	7.331e-20	99.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,2VVRU@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD3_k127_6283956_3	887898.HMPREF0551_0814	5.419e-94	338.0	COG1570@1|root,COG1570@2|Bacteria,1QWH2@1224|Proteobacteria,2WGZR@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
HKD3_k127_6283956_1	204773.HEAR0811	2.004e-132	432.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHGM@28216|Betaproteobacteria,472EG@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type spermidine putrescine transport system, ATPase component	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD3_k127_6283956_2	1454004.AW11_01753	1.005e-131	441.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VI20@28216|Betaproteobacteria,1KQ7Q@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	fbpB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD3_k127_6283956_0	1123392.AQWL01000005_gene2962	1.153e-225	707.0	COG0446@1|root,COG0446@2|Bacteria,1PVXQ@1224|Proteobacteria,2WBJS@28216|Betaproteobacteria,1KS2X@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_6319267_15	1121861.KB899913_gene2257	1.255e-74	257.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,2JRW6@204441|Rhodospirillales	204441|Rhodospirillales	S	DJ-1/PfpI family	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD3_k127_6319267_10	640081.Dsui_1067	1.505e-94	334.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2WGGV@28216|Betaproteobacteria,2KZX5@206389|Rhodocyclales	206389|Rhodocyclales	T	Member of a two-component regulatory system	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA
HKD3_k127_6319267_8	497321.C664_14104	2.387e-103	340.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,2KVAP@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_6319267_3	698761.RTCIAT899_CH01170	5.956e-179	568.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,4BC2D@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	MA20_06210	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD3_k127_6319267_5	1499502.EV12_0046	3.669e-170	550.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	asdA	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD3_k127_6319267_12	1502851.FG93_01574	7.043e-91	322.0	COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2TX6U@28211|Alphaproteobacteria,3JRXZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	MA20_29065	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_6319267_26	305900.GV64_21140	9.056e-28	130.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1S42H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Nitrous oxide-stimulated promoter	ygbA	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
HKD3_k127_6319267_21	1163617.SCD_n02334	1.409e-55	219.0	COG4252@1|root,COG4252@2|Bacteria,1R9GK@1224|Proteobacteria,2VKE8@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM CHASE2 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2
HKD3_k127_6319267_22	1165096.ARWF01000001_gene497	6.633e-54	206.0	COG4783@1|root,COG4783@2|Bacteria,1R84W@1224|Proteobacteria,2VIBK@28216|Betaproteobacteria,2KKQH@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD3_k127_6319267_27	1223521.BBJX01000009_gene1196	1.069e-07	61.0	COG3103@1|root,COG3103@2|Bacteria,1N6AX@1224|Proteobacteria,2VVME@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
HKD3_k127_6319267_25	522306.CAP2UW1_1836	3.287e-30	133.0	2CG45@1|root,33GFC@2|Bacteria,1NKZR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6319267_4	522306.CAP2UW1_1835	4.611e-172	563.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VKYS@28216|Betaproteobacteria,1KR3R@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Inorganic ion transport and metabolism	ybhI	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
HKD3_k127_6319267_18	1238182.C882_3275	1.693e-58	218.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,2JZR9@204441|Rhodospirillales	204441|Rhodospirillales	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	-	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
HKD3_k127_6319267_2	395495.Lcho_3670	7.137e-195	610.0	COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,2VM1T@28216|Betaproteobacteria,1KK11@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Cupin domain	-	-	1.13.11.4	ko:K00450	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R02656	RC00764	ko00000,ko00001,ko01000	-	-	-	Cupin_2
HKD3_k127_6319267_1	395495.Lcho_3669	1.206e-229	717.0	COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2VISJ@28216|Betaproteobacteria,1KJYB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CH	FAD binding domain	mhbM	-	1.14.13.1,1.14.13.24	ko:K00480,ko:K22270	ko00362,ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00362,map00621,map00624,map00626,map01100,map01120,map01220	-	R00818,R02589,R05632,R06915,R06936,R06939	RC00046,RC00389	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HKD3_k127_6319267_6	522306.CAP2UW1_1272	2.809e-129	422.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD3_k127_6319267_17	420662.Mpe_A1075	2.41e-59	209.0	COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,2VQFF@28216|Betaproteobacteria,1KKUR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sensors of blue-light using FAD	-	-	-	-	-	-	-	-	-	-	-	-	BLUF
HKD3_k127_6319267_7	1265502.KB905942_gene2801	1.769e-118	386.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2VH10@28216|Betaproteobacteria,4AA1H@80864|Comamonadaceae	28216|Betaproteobacteria	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD3_k127_6319267_9	745776.DGo_CA2042	1.583e-100	356.0	COG0604@1|root,COG1109@1|root,COG0604@2|Bacteria,COG1109@2|Bacteria	2|Bacteria	G	phosphoglucosamine mutase activity	mpg	-	1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8	ko:K00344,ko:K01840,ko:K03431,ko:K15778,ko:K16881	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00362	R00885,R00959,R01057,R01818,R02060,R08639	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3178	ADH_N,ADH_zinc_N,Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
HKD3_k127_6319267_14	1276756.AUEX01000030_gene200	1.017e-78	268.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2VQ0V@28216|Betaproteobacteria,4AGUW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD3_k127_6319267_19	887062.HGR_08149	2.704e-58	215.0	COG3181@1|root,COG3181@2|Bacteria,1N4MC@1224|Proteobacteria,2VKJS@28216|Betaproteobacteria,4ABJ4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6319267_20	402881.Plav_2019	1.536e-56	209.0	COG0625@1|root,COG0625@2|Bacteria,1RG4U@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD3_k127_6319267_11	937777.Deipe_0653	7.321e-92	308.0	COG0778@1|root,COG0778@2|Bacteria,1WMP2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_6319267_13	1207063.P24_00920	4.007e-89	302.0	COG1024@1|root,COG1024@2|Bacteria,1PU1Q@1224|Proteobacteria,2TSW6@28211|Alphaproteobacteria,2JS2P@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_6319267_16	1038867.AXAY01000028_gene4730	1.667e-59	229.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,Response_reg
HKD3_k127_6319267_24	640511.BC1002_5532	1.052e-32	146.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2VQH8@28216|Betaproteobacteria,1JZZ5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_6319267_0	522306.CAP2UW1_3016	1.63e-271	840.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2W02M@28216|Betaproteobacteria,1KQIF@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Fumarase C C-terminus	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD3_k127_6319267_23	522306.CAP2UW1_3015	1.609e-38	145.0	COG2704@1|root,COG2704@2|Bacteria,1MVHH@1224|Proteobacteria,2VI3D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane	-	-	-	ko:K07791,ko:K07792	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.13.1	-	-	DcuA_DcuB
HKD3_k127_6320531_4	1095769.CAHF01000011_gene2469	5.531e-27	112.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,47411@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD3_k127_6320531_0	1095769.CAHF01000011_gene2470	7.728e-310	968.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,47274@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD3_k127_6320531_1	93220.LV28_04385	2.739e-151	498.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,1JZQM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD3_k127_6320531_3	977880.RALTA_A1264	2.609e-53	189.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,1K7MK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD3_k127_6320531_5	257313.BP2576	5.963e-26	108.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2VVS9@28216|Betaproteobacteria,3T4MY@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD3_k127_6320531_2	859657.RPSI07_1666	1.882e-85	285.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,1K20G@119060|Burkholderiaceae	28216|Betaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD3_k127_6365121_0	381666.H16_A3272	5.641e-227	711.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,1K0U8@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_6365121_4	795666.MW7_3104	3.652e-130	423.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,1K3MM@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD3_k127_6365121_8	93220.LV28_11435	9.737e-74	270.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VPPY@28216|Betaproteobacteria,1K2BW@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD3_k127_6365121_1	1218076.BAYB01000035_gene5267	5.856e-209	670.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,1K1ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD3_k127_6365121_2	887898.HMPREF0551_1805	1.016e-169	562.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1K1ET@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD3_k127_6365121_7	1095769.CAHF01000014_gene2902	1.845e-75	263.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2VQDH@28216|Betaproteobacteria,4736X@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Redoxin	ahp1	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
HKD3_k127_6365121_3	1229205.BUPH_03630	1.431e-130	435.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,1K1EA@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HKD3_k127_6365121_6	1005048.CFU_3932	3.528e-79	278.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,4735M@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidase family M23	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD3_k127_6365121_5	1532557.JL37_05635	2.942e-101	334.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,3T1D5@506|Alcaligenaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD3_k127_6525610_2	75379.Tint_2731	8.543e-92	306.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KJHG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
HKD3_k127_6525610_1	257310.BB4947	2.941e-175	565.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,3T2VG@506|Alcaligenaceae	28216|Betaproteobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	thlA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_6525610_3	1095769.CAHF01000005_gene1516	3.486e-65	229.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria,474F7@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_6525610_0	1095769.CAHF01000005_gene1515	8.838e-187	587.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,473VB@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_6576890_8	342113.DM82_3600	3.099e-26	110.0	2E6W9@1|root,331FT@2|Bacteria,1N6E1@1224|Proteobacteria,2VVIR@28216|Betaproteobacteria,1K8KB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3567)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3567
HKD3_k127_6576890_4	795666.MW7_0241	1.567e-55	197.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2VTFS@28216|Betaproteobacteria,1KGTK@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD3_k127_6576890_2	614083.AWQR01000018_gene1882	5.384e-177	577.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VIE2@28216|Betaproteobacteria,4ACB3@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_6576890_6	338969.Rfer_2568	2.242e-32	131.0	COG3090@1|root,COG3090@2|Bacteria,1N9D4@1224|Proteobacteria,2VT71@28216|Betaproteobacteria,4AEJZ@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_6576890_3	392499.Swit_0978	1.222e-65	241.0	COG0596@1|root,COG0596@2|Bacteria,1QTTN@1224|Proteobacteria,2TRYE@28211|Alphaproteobacteria,2KEJ2@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HKD3_k127_6576890_0	114615.BRADO6657	1.94e-211	673.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,3JV2C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD3_k127_6576890_1	1037409.BJ6T_10970	1.771e-196	629.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2VG5K@28211|Alphaproteobacteria,3JTG6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the glutamine synthetase family	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N_2
HKD3_k127_6576890_7	1157708.KB907451_gene4530	3.31e-30	125.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VUR1@28216|Betaproteobacteria,4AFGK@80864|Comamonadaceae	28216|Betaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD3_k127_6576890_5	296591.Bpro_2121	1.607e-40	154.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2VHPP@28216|Betaproteobacteria,4ABME@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_6637024_5	1304877.KI519401_gene148	1.454e-46	168.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,3JWDR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD3_k127_6637024_0	1230476.C207_00063	1.166e-316	980.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,3JTHV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD3_k127_6637024_3	296591.Bpro_5288	1.1e-143	460.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VKNX@28216|Betaproteobacteria,4AGAH@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_6637024_1	296591.Bpro_5289	5.674e-172	580.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VKRB@28216|Betaproteobacteria,4AH8B@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_6637024_2	296591.Bpro_5290	5.248e-147	469.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VPSZ@28216|Betaproteobacteria,4AGSP@80864|Comamonadaceae	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD3_k127_6637024_4	296591.Bpro_5291	6.764e-105	346.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VPF7@28216|Betaproteobacteria,4AG9A@80864|Comamonadaceae	28216|Betaproteobacteria	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_670744_1	383372.Rcas_0822	4.412e-157	513.0	COG3844@1|root,COG3844@2|Bacteria,2G5K1@200795|Chloroflexi,3767U@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD3_k127_670744_3	292.DM42_2492	1.651e-82	279.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,2VHG4@28216|Betaproteobacteria,1K19R@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation	kynB	GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HKD3_k127_670744_0	1411123.JQNH01000001_gene266	4.221e-267	851.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HKD3_k127_670744_10	196367.JNFG01000202_gene2675	6.149e-20	97.0	2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,2VWNF@28216|Betaproteobacteria,1K7Q8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
HKD3_k127_670744_4	269482.Bcep1808_2665	7.909e-76	260.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2VR6F@28216|Betaproteobacteria,1K3ZU@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD3_k127_670744_8	243365.CV_0043	1.453e-39	156.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,2KPMA@206351|Neisseriales	206351|Neisseriales	KLT	Psort location Extracellular, score	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD3_k127_670744_2	887898.HMPREF0551_0280	3.583e-83	280.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,1K4XA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM LemA family protein	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD3_k127_670744_5	582744.Msip34_2282	1.552e-65	237.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,2KKKF@206350|Nitrosomonadales	206350|Nitrosomonadales	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD3_k127_670744_6	595537.Varpa_5494	7.984e-42	162.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria,4AE80@80864|Comamonadaceae	28216|Betaproteobacteria	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
HKD3_k127_670744_9	1122604.JONR01000011_gene3597	4.559e-35	136.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,1S9WR@1236|Gammaproteobacteria,1X7YI@135614|Xanthomonadales	135614|Xanthomonadales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HKD3_k127_670744_7	335283.Neut_0167	7.155e-41	153.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,2VVD3@28216|Betaproteobacteria,374NS@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HKD3_k127_6728241_0	614083.AWQR01000033_gene2861	1.319e-229	722.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,4AB9I@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD3_k127_6728241_1	614083.AWQR01000047_gene3310	1.533e-134	442.0	COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2W52I@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_6728241_2	1276756.AUEX01000038_gene319	1.401e-44	171.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2W334@28216|Betaproteobacteria,4AJRG@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K08365	-	-	-	-	ko00000,ko03000	-	-	-	-
HKD3_k127_6728241_3	1122223.KB890700_gene2046	6.749e-23	114.0	COG4447@1|root,COG4447@2|Bacteria,1WJIB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6808202_1	640511.BC1002_0380	1.363e-298	924.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,1K43H@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD3_k127_6808202_16	864073.HFRIS_012159	1.257e-48	179.0	COG4731@1|root,COG4731@2|Bacteria,1N19Y@1224|Proteobacteria,2VTB1@28216|Betaproteobacteria,474EH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD3_k127_6808202_0	1095769.CAHF01000014_gene2922	0.0	1049.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VHS7@28216|Betaproteobacteria,472G4@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD3_k127_6808202_5	1031711.RSPO_c02919	1.213e-192	645.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,1K1ZJ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_6808202_14	1218352.B597_008530	8.117e-69	246.0	COG4757@1|root,COG4757@2|Bacteria,1Q1V6@1224|Proteobacteria,1S3FE@1236|Gammaproteobacteria,1YZU9@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD3_k127_6808202_11	267608.RSc0476	8.631e-98	326.0	COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,2VJC1@28216|Betaproteobacteria,1JZXT@119060|Burkholderiaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_6808202_15	1122604.JONR01000011_gene3604	1.087e-60	221.0	COG2755@1|root,COG2755@2|Bacteria,1RE1B@1224|Proteobacteria,1S42Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD3_k127_6808202_9	1121116.KB894769_gene1386	9.076e-103	340.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2VJSH@28216|Betaproteobacteria,4ACA4@80864|Comamonadaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	echA8_4	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_6808202_4	381666.H16_B0722	5.754e-194	612.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,1JZSR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_6808202_8	258594.RPA4798	2.494e-146	476.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TVBB@28211|Alphaproteobacteria,3JRDX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	acyl-CoA dehydrogenase	MA20_22775	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_6808202_2	59538.XP_005973478.1	1.504e-267	854.0	COG0318@1|root,KOG1176@2759|Eukaryota,3AIZB@33154|Opisthokonta,3BXNQ@33208|Metazoa,3DFMP@33213|Bilateria,48SPA@7711|Chordata,49P71@7742|Vertebrata,3JP3T@40674|Mammalia,4J1NF@91561|Cetartiodactyla	33208|Metazoa	I	4-coumarate--CoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_6808202_7	1123504.JQKD01000004_gene5106	2.855e-154	533.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,4AAKM@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_6808202_17	1123504.JQKD01000083_gene51	1.375e-42	160.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,4AE0U@80864|Comamonadaceae	28216|Betaproteobacteria	I	Thioesterase superfamily protein	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD3_k127_6808202_3	204773.HEAR0223	1.4e-251	790.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2WGG3@28216|Betaproteobacteria,473CU@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ABC transporter transmembrane region	atm1	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_6808202_18	247633.GP2143_09515	3.172e-27	115.0	2E5A1@1|root,3302A@2|Bacteria,1NCFQ@1224|Proteobacteria,1SCB3@1236|Gammaproteobacteria,1J7BQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6808202_10	247634.GPB2148_3218	3.295e-101	342.0	COG2141@1|root,COG2141@2|Bacteria,1MXZH@1224|Proteobacteria,1RMB2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate	rutA	GO:0003674,GO:0003824,GO:0004497,GO:0006139,GO:0006206,GO:0006208,GO:0006210,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0017144,GO:0019740,GO:0019859,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0052614,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	1.14.99.46	ko:K09018	ko00240,ko01100,map00240,map01100	-	R09936	RC02732	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_1123,iECUMN_1333.ECUMN_1195	Bac_luciferase
HKD3_k127_6808202_12	1265313.HRUBRA_01450	1.605e-84	317.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria	1224|Proteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD3_k127_6808202_19	279238.Saro_2258	1.736e-25	114.0	COG2717@1|root,COG2717@2|Bacteria,1R4CY@1224|Proteobacteria,2U37R@28211|Alphaproteobacteria,2K8AU@204457|Sphingomonadales	204457|Sphingomonadales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6808202_6	1137799.GZ78_21130	8.512e-163	534.0	2DB85@1|root,2Z7Q2@2|Bacteria,1R8UP@1224|Proteobacteria,1S1P0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD3_k127_6808202_13	1219035.NT2_12_00280	4.644e-82	300.0	COG1028@1|root,COG1028@2|Bacteria,1NAZS@1224|Proteobacteria,2U2UF@28211|Alphaproteobacteria,2K3IT@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_686339_5	85643.Tmz1t_1275	1.283e-129	441.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales	206389|Rhodocyclales	P	cation transport ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD3_k127_686339_13	580332.Slit_2584	4.612e-50	188.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,44VB0@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HKD3_k127_686339_6	180281.CPCC7001_664	4.62e-113	381.0	COG0182@1|root,COG0182@2|Bacteria,1G2JX@1117|Cyanobacteria,22RUG@167375|Cyanobium	1117|Cyanobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD3_k127_686339_12	187272.Mlg_2778	6.116e-60	215.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,1RPIK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde	fucA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006004,GO:0008150,GO:0008152,GO:0008270,GO:0008738,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019317,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019571,GO:0042354,GO:0042355,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046372,GO:0046872,GO:0046914,GO:0071704,GO:1901575	4.1.1.104,4.1.2.17	ko:K01628,ko:K22130	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD3_k127_686339_7	358220.C380_21540	4.916e-92	324.0	COG3181@1|root,COG3181@2|Bacteria,1R43T@1224|Proteobacteria,2VHTA@28216|Betaproteobacteria,4ACZZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_686339_0	1095769.CAHF01000003_gene1026	0.0	1499.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,472IP@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD3_k127_686339_3	204773.HEAR3097	6.232e-132	433.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,473ZV@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	yajR	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_686339_11	75379.Tint_0071	2.04e-64	225.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,1KKNH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD3_k127_686339_15	1500897.JQNA01000002_gene1667	3.355e-29	123.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,1K99W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD3_k127_686339_8	1144342.PMI40_04765	3.743e-80	276.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,4761R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD3_k127_686339_1	983917.RGE_10940	0.0	1048.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1KITM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD3_k127_686339_17	365046.Rta_31150	6.304e-19	89.0	COG2161@1|root,COG2161@2|Bacteria,1NCR3@1224|Proteobacteria,2VX6A@28216|Betaproteobacteria,4AIGE@80864|Comamonadaceae	28216|Betaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD3_k127_686339_16	365046.Rta_31140	9.132e-27	117.0	2DNNV@1|root,32YCB@2|Bacteria,1N7IN@1224|Proteobacteria,2VW4Y@28216|Betaproteobacteria,4AFI3@80864|Comamonadaceae	28216|Betaproteobacteria	S	CcdB protein	-	-	-	ko:K19163	-	-	-	-	ko00000,ko02048	-	-	-	CcdB
HKD3_k127_686339_10	395495.Lcho_4015	7.5e-73	252.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,1KKSR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Nudix hydrolase	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HKD3_k127_686339_4	987059.RBXJA2T_07110	7.149e-131	430.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,1KJGQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD3_k127_686339_2	987059.RBXJA2T_07115	1.455e-153	511.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,1KJH6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsB	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD3_k127_686339_14	1108045.GORHZ_084_00430	3.614e-44	172.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4GEP0@85026|Gordoniaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_686339_9	296591.Bpro_1766	7.605e-77	269.0	COG3181@1|root,COG3181@2|Bacteria,1Q5FF@1224|Proteobacteria,2VIJ9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6873520_21	987059.RBXJA2T_03773	1.232e-27	116.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,1KMFU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CbiX	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD3_k127_6873520_8	795666.MW7_0328	8.393e-122	398.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,1K0Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	K	RNA polymerase sigma factor RpoH	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD3_k127_6873520_11	748247.AZKH_4359	2.791e-78	268.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,2KYH3@206389|Rhodocyclales	206389|Rhodocyclales	O	maleylacetoacetate isomerase	-	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_N_3
HKD3_k127_6873520_20	439235.Dalk_2685	6.502e-35	153.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,42T1Y@68525|delta/epsilon subdivisions,2WU6P@28221|Deltaproteobacteria,2MPS0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	7TMR-DISM extracellular 2	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
HKD3_k127_6873520_7	887898.HMPREF0551_2411	1.099e-122	427.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,1K038@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD3_k127_6873520_3	375286.mma_3139	1.328e-166	537.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,472VG@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD3_k127_6873520_4	1366050.N234_01700	1.99e-143	490.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,1K5HE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD3_k127_6873520_16	76114.ebA1396	1.509e-49	187.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,2KWFM@206389|Rhodocyclales	206389|Rhodocyclales	L	methyltransferase	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD3_k127_6873520_12	1095769.CAHF01000014_gene2967	5.121e-64	231.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,472CA@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_6873520_18	864073.HFRIS_001964	4.465e-43	158.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,474S4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S binding domain	fdx1	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
HKD3_k127_6873520_17	944435.AXAJ01000008_gene1424	2.101e-44	170.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,1K7HX@119060|Burkholderiaceae	28216|Betaproteobacteria	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD3_k127_6873520_2	83406.HDN1F_28520	8.684e-201	655.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1J527@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iECs_1301.ECs5024,iG2583_1286.G2583_4866	Acyltransferase
HKD3_k127_6873520_5	1038869.AXAN01000031_gene530	4.274e-143	470.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,1K0ST@119060|Burkholderiaceae	28216|Betaproteobacteria	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD3_k127_6873520_1	887898.HMPREF0551_2437	1.488e-273	863.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,1K1YJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD3_k127_6873520_6	266264.Rmet_0542	1.361e-137	447.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2VMCZ@28216|Betaproteobacteria,1K6MT@119060|Burkholderiaceae	28216|Betaproteobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HKD3_k127_6873520_15	75379.Tint_3059	1.219e-49	187.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2VSFP@28216|Betaproteobacteria,1KM3R@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	nitroreductase	aoxC	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_6873520_14	987059.RBXJA2T_07408	3.303e-51	198.0	COG2863@1|root,COG2863@2|Bacteria,1RCAT@1224|Proteobacteria,2VR47@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_6873520_13	338969.Rfer_3089	1.305e-62	232.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,4AGRB@80864|Comamonadaceae	28216|Betaproteobacteria	H	Molybdopterin guanine dinucleotide synthesis protein B	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
HKD3_k127_6873520_19	398767.Glov_1147	4.02e-35	143.0	COG3381@1|root,COG3381@2|Bacteria,1NHV1@1224|Proteobacteria,42VXM@68525|delta/epsilon subdivisions,2WSGF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM cytoplasmic chaperone TorD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HKD3_k127_6873520_10	762966.HMPREF9439_00275	3.978e-90	303.0	COG0437@1|root,COG0437@2|Bacteria,1RCHX@1224|Proteobacteria	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_3,Fer4_4
HKD3_k127_6873520_0	398767.Glov_1149	0.0	1170.0	COG0243@1|root,COG0243@2|Bacteria,1R5ZE@1224|Proteobacteria,42QK1@68525|delta/epsilon subdivisions,2WPX8@28221|Deltaproteobacteria,43V0Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HKD3_k127_6873520_22	1121035.AUCH01000004_gene422	1.211e-21	96.0	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,2VU78@28216|Betaproteobacteria,2KXCG@206389|Rhodocyclales	206389|Rhodocyclales	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD3_k127_6873520_9	1304883.KI912532_gene1891	1.381e-102	338.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria,2KVB8@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD3_k127_69388_2	1095769.CAHF01000013_gene3337	5.196e-151	482.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,4725K@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	AIR synthase related protein, N-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD3_k127_69388_5	887898.HMPREF0551_1970	7.109e-116	396.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2VHW1@28216|Betaproteobacteria,1K153@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM surface antigen (D15)	tama	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HKD3_k127_69388_6	887898.HMPREF0551_1969	3.898e-104	385.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,1K000@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	tamB	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD3_k127_69388_3	296591.Bpro_1838	1.138e-144	477.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2WAPZ@28216|Betaproteobacteria,4AFUJ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD3_k127_69388_8	215803.DB30_4612	3.207e-44	170.0	COG3265@1|root,COG3265@2|Bacteria,1RHD0@1224|Proteobacteria,43818@68525|delta/epsilon subdivisions,2X9US@28221|Deltaproteobacteria,2YV7Z@29|Myxococcales	28221|Deltaproteobacteria	F	Shikimate kinase	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	SKI
HKD3_k127_69388_4	93220.LV28_09160	7.43e-121	398.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD3_k127_69388_0	391735.Veis_0623	1.366e-244	771.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,4A9Q2@80864|Comamonadaceae	28216|Betaproteobacteria	M	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_69388_7	1265502.KB905931_gene1642	2.076e-85	302.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2VJ74@28216|Betaproteobacteria,4AB8F@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	ko:K07552,ko:K18552	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.2,2.A.1.2.3	-	-	MFS_1
HKD3_k127_69388_1	1123367.C666_09890	9.398e-161	521.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,2KVF9@206389|Rhodocyclales	206389|Rhodocyclales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD3_k127_6981012_0	1095769.CAHF01000007_gene1651	3.257e-310	973.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,472I0@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD3_k127_6981012_14	266264.Rmet_5631	3.019e-64	247.0	COG1802@1|root,COG1802@2|Bacteria,1N7GE@1224|Proteobacteria,2VNZS@28216|Betaproteobacteria,1K0M2@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD3_k127_6981012_3	94624.Bpet4350	3.276e-191	620.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,3T51C@506|Alcaligenaceae	28216|Betaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD3_k127_6981012_7	543913.D521_0713	6.35e-129	421.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6981012_9	94624.Bpet4354	1.022e-111	383.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,3T393@506|Alcaligenaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_6981012_4	1007105.PT7_1569	2.589e-187	595.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,3T2PV@506|Alcaligenaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD3_k127_6981012_6	667632.KB890184_gene415	1.516e-146	475.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,1K22Z@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM aminotransferase class I and II	aspB	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD3_k127_6981012_16	757424.Hsero_3582	3.435e-42	167.0	COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,4740U@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD3_k127_6981012_1	887898.HMPREF0551_0209	1.09e-266	829.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,1JZXF@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD3_k127_6981012_18	443144.GM21_2449	6.157e-19	102.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria	1224|Proteobacteria	S	PFAM VanZ family protein	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD3_k127_6981012_11	883126.HMPREF9710_03661	2.329e-97	329.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2VM30@28216|Betaproteobacteria,475TU@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_6981012_2	395494.Galf_2121	9.411e-203	640.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,44V4J@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
HKD3_k127_6981012_5	1123354.AUDR01000018_gene1203	2.825e-157	510.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,1KRH5@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD3_k127_6981012_17	1123354.AUDR01000018_gene1207	2.2e-35	140.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VR37@28216|Betaproteobacteria	28216|Betaproteobacteria	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_6981012_10	1429916.X566_16335	3.459e-102	361.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,3JUVR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Iron-containing alcohol dehydrogenase	MA20_22910	-	1.3.1.32	ko:K00217	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	-	R02988,R02989,R05355,R06848,R07781,R09137,R09138,R09223,R09224	RC00107,RC01335,RC01689,RC02442	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD3_k127_6981012_12	1205680.CAKO01000042_gene5324	1.476e-85	303.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRQS@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD3_k127_6981012_15	1122604.JONR01000009_gene2366	1.431e-61	231.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1MWIC@1224|Proteobacteria,1RNX4@1236|Gammaproteobacteria,1X5R4@135614|Xanthomonadales	135614|Xanthomonadales	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
HKD3_k127_6981012_13	420324.KI912007_gene8886	1.064e-77	280.0	COG0697@1|root,COG0697@2|Bacteria,1PB22@1224|Proteobacteria,2U158@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_36650	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_6981012_8	580332.Slit_2067	2.497e-122	396.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,44VKB@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD3_k127_7044322_26	243365.CV_1898	2.162e-31	124.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,2KRXR@206351|Neisseriales	206351|Neisseriales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD3_k127_7044322_16	1123368.AUIS01000005_gene383	1.318e-66	231.0	COG3255@1|root,COG3255@2|Bacteria,1N5G0@1224|Proteobacteria,1S8QU@1236|Gammaproteobacteria,2NCWZ@225057|Acidithiobacillales	225057|Acidithiobacillales	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD3_k127_7044322_17	1231391.AMZF01000046_gene940	3.437e-64	243.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VHZA@28216|Betaproteobacteria,3T5DE@506|Alcaligenaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	urtC	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD3_k127_7044322_13	1231391.AMZF01000046_gene941	1.33e-83	295.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJ7X@28216|Betaproteobacteria,3T5N7@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD3_k127_7044322_19	1231391.AMZF01000046_gene942	9.67e-58	210.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,3T4AH@506|Alcaligenaceae	28216|Betaproteobacteria	E	abc transporter, ATP-binding protein	-	-	-	ko:K01996,ko:K11963	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
HKD3_k127_7044322_18	1040982.AXAL01000003_gene3681	9.95e-63	224.0	COG4674@1|root,COG4674@2|Bacteria,1PHYH@1224|Proteobacteria,2TVYS@28211|Alphaproteobacteria,43RKK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_7044322_7	172088.AUGA01000003_gene5743	3.901e-115	387.0	COG0683@1|root,COG0683@2|Bacteria,1MUZU@1224|Proteobacteria,2U7FA@28211|Alphaproteobacteria,3K3EU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_7044322_11	1297865.APJD01000007_gene2085	1.391e-97	322.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2TRMB@28211|Alphaproteobacteria,3JSHT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HKD3_k127_7044322_30	234267.Acid_3392	1.341e-15	86.0	2E74W@1|root,331P9@2|Bacteria,3Y8XR@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HKD3_k127_7044322_22	1218084.BBJK01000016_gene1759	1.293e-50	198.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,2WFUS@28216|Betaproteobacteria,1KA6V@119060|Burkholderiaceae	28216|Betaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7044322_28	1121106.JQKB01000011_gene293	3.329e-25	111.0	COG2050@1|root,COG2050@2|Bacteria,1RHP8@1224|Proteobacteria,2UA1N@28211|Alphaproteobacteria,2JY37@204441|Rhodospirillales	204441|Rhodospirillales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD3_k127_7044322_1	398767.Glov_1816	4.171e-223	716.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
HKD3_k127_7044322_24	1265502.KB905945_gene619	1.083e-40	156.0	COG1846@1|root,COG1846@2|Bacteria,1PW9W@1224|Proteobacteria,2VUDE@28216|Betaproteobacteria,4AID2@80864|Comamonadaceae	28216|Betaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD3_k127_7044322_0	1095769.CAHF01000022_gene274	6.405e-310	966.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2VIAZ@28216|Betaproteobacteria,478Q4@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD3_k127_7044322_25	983917.RGE_23560	9.107e-40	171.0	COG1877@1|root,COG1877@2|Bacteria,1PFWC@1224|Proteobacteria,2VXSM@28216|Betaproteobacteria,1KMU2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HKD3_k127_7044322_9	1267535.KB906767_gene559	3.695e-106	352.0	COG4221@1|root,COG4221@2|Bacteria,3Y7F8@57723|Acidobacteria	57723|Acidobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_7044322_14	1280950.HJO_00725	5.912e-76	274.0	COG1024@1|root,COG1024@2|Bacteria,1NJ9M@1224|Proteobacteria,2U07X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase	MA20_29580	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_7044322_12	420662.Mpe_A2294	1.607e-95	340.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria,1KPCQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7044322_4	1266925.JHVX01000004_gene1184	6.382e-148	476.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,372GN@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD3_k127_7044322_8	522306.CAP2UW1_1637	3.496e-107	373.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KQVC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K02054,ko:K11071	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	BPD_transp_1
HKD3_k127_7044322_10	323848.Nmul_A0980	3.469e-103	342.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2VHYY@28216|Betaproteobacteria,371NB@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HKD3_k127_7044322_3	580332.Slit_1195	6.169e-154	494.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K02055,ko:K11069	ko02010,ko02024,map02010,map02024	M00193,M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
HKD3_k127_7044322_2	1000565.METUNv1_03023	1.771e-158	522.0	COG4389@1|root,COG4389@2|Bacteria,1MWEH@1224|Proteobacteria,2VIZV@28216|Betaproteobacteria,2KUTK@206389|Rhodocyclales	206389|Rhodocyclales	L	Site-specific recombinase	-	-	-	-	-	-	-	-	-	-	-	-	SpecificRecomb
HKD3_k127_7044322_5	1100720.ALKN01000045_gene319	4.69e-124	406.0	COG3181@1|root,COG3181@2|Bacteria,1N7C4@1224|Proteobacteria,2VHNI@28216|Betaproteobacteria,4A9W4@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_7044322_27	887898.HMPREF0551_2579	6.777e-26	119.0	COG3165@1|root,COG3165@2|Bacteria	2|Bacteria	S	ubiquinone biosynthetic process from chorismate	yigP	GO:0006082,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0019752,GO:0032150,GO:0042180,GO:0042181,GO:0043436,GO:0043648,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046417,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
HKD3_k127_7044322_29	518766.Rmar_0114	2.577e-23	114.0	COG0797@1|root,COG0797@2|Bacteria,4NSF1@976|Bacteroidetes,1FJK1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
HKD3_k127_7044322_15	1071679.BG57_21595	1.935e-73	259.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2VNS7@28216|Betaproteobacteria,1K2V5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD3_k127_7044322_6	1392838.AWNM01000063_gene4125	6.177e-117	390.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,3T209@506|Alcaligenaceae	28216|Betaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD3_k127_7044322_21	977880.RALTA_A0386	1.909e-52	190.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,1K72E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HKD3_k127_7044322_23	257310.BB0220	8.84e-45	173.0	COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,2VU7S@28216|Betaproteobacteria,3T4H4@506|Alcaligenaceae	28216|Betaproteobacteria	FG	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit	-	-	-	-	-	-	-	-	-	-	-	HIT
HKD3_k127_7044322_20	1205680.CAKO01000038_gene1832	1.142e-57	203.0	COG1028@1|root,COG1028@2|Bacteria,1MWGK@1224|Proteobacteria,2TVQ8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_16385	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD3_k127_7075083_3	1502852.FG94_00579	9.812e-218	683.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,472V4@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	DAO,ETF_QO,FAD_binding_2,NAD_binding_8
HKD3_k127_7075083_5	290397.Adeh_0008	6.929e-158	522.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2YUAI@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD3_k127_7075083_9	1031711.RSPO_c01642	2.058e-121	402.0	COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria,1K27Y@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	short-chain dehydrogenase	gno2	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_7075083_4	460265.Mnod_1189	9.627e-163	522.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,1JV9G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Cytochrome P450	MA20_16830	-	-	-	-	-	-	-	-	-	-	-	p450
HKD3_k127_7075083_12	1121106.JQKB01000015_gene5801	6.934e-106	359.0	COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2TSQJ@28211|Alphaproteobacteria,2JQW2@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
HKD3_k127_7075083_19	864051.BurJ1DRAFT_2282	1.93e-48	176.0	COG0824@1|root,COG0824@2|Bacteria,1MZTU@1224|Proteobacteria,2VSY8@28216|Betaproteobacteria,1KM7F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Thioesterase superfamily	fcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD3_k127_7075083_11	1247649.D560_2354	3.646e-115	377.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2VII6@28216|Betaproteobacteria,3T1EW@506|Alcaligenaceae	28216|Betaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit	lpsJ	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_7075083_8	1003200.AXXA_17586	2.248e-123	406.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2VHFT@28216|Betaproteobacteria,3T2VY@506|Alcaligenaceae	28216|Betaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	lpsI	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_7075083_15	1502852.FG94_00610	2.785e-75	276.0	COG1230@1|root,COG1230@2|Bacteria,1QUZ5@1224|Proteobacteria,2WGMK@28216|Betaproteobacteria,4764Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Cation efflux family	zitB	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Abhydrolase_6,Cation_efflux
HKD3_k127_7075083_0	887898.HMPREF0551_1079	5.321e-291	930.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,1K150@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD3_k127_7075083_7	1095769.CAHF01000010_gene1215	3.783e-138	447.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,472KM@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD3_k127_7075083_20	1379270.AUXF01000002_gene1141	6.081e-34	140.0	COG5470@1|root,COG5470@2|Bacteria,1ZU5S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_7075083_1	1265502.KB905931_gene1666	7.054e-242	751.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,4A9T6@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD3_k127_7075083_21	640081.Dsui_2318	4.672e-29	124.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,2KX4Q@206389|Rhodocyclales	206389|Rhodocyclales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD3_k127_7075083_14	1458357.BG58_11635	4.828e-92	319.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,1K4UW@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD3_k127_7075083_18	1122180.Lokhon_01953	3.507e-64	230.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,2P8RT@245186|Loktanella	28211|Alphaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	dapH	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD3_k127_7075083_16	1381123.AYOD01000035_gene3677	1.141e-68	243.0	COG2186@1|root,COG2186@2|Bacteria,1R5KH@1224|Proteobacteria,2TSJE@28211|Alphaproteobacteria,43PFQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD3_k127_7075083_2	864051.BurJ1DRAFT_1690	1.796e-224	703.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2VKVZ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_7075083_6	864051.BurJ1DRAFT_1689	2.285e-144	462.0	COG0559@1|root,COG0559@2|Bacteria,1MYEW@1224|Proteobacteria,2VKZN@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_7075083_10	864051.BurJ1DRAFT_1688	1.963e-117	401.0	COG4177@1|root,COG4177@2|Bacteria,1QF6I@1224|Proteobacteria,2VRRP@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_7075083_13	864051.BurJ1DRAFT_1687	6.597e-100	347.0	COG0411@1|root,COG0411@2|Bacteria,1R5MA@1224|Proteobacteria,2VQBK@28216|Betaproteobacteria	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_7075083_17	864051.BurJ1DRAFT_1686	3.525e-65	242.0	COG0410@1|root,COG0410@2|Bacteria,1R5HF@1224|Proteobacteria,2VS8X@28216|Betaproteobacteria	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_70809_0	1265502.KB905946_gene1123	0.0	1941.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,4A9MX@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
HKD3_k127_70809_1	1265502.KB905946_gene1125	3.35e-229	729.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,4ABDA@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM Major facilitator superfamily	narK1	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD3_k127_70809_3	338969.Rfer_1869	5.065e-87	296.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,4AAZ1@80864|Comamonadaceae	28216|Betaproteobacteria	K	response regulator, receiver	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD3_k127_70809_2	1265502.KB905946_gene1127	3.545e-178	580.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,4AAJ9@80864|Comamonadaceae	28216|Betaproteobacteria	T	histidine kinase, dimerisation and phosphoacceptor region	narX	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA_3,PilJ
HKD3_k127_70809_4	1380394.JADL01000003_gene5080	2.422e-76	270.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,2JRVV@204441|Rhodospirillales	204441|Rhodospirillales	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_70809_5	76114.ebB92	1.801e-11	70.0	COG3312@1|root,COG3312@2|Bacteria,1NDM1@1224|Proteobacteria,2VWW4@28216|Betaproteobacteria,2KXMC@206389|Rhodocyclales	206389|Rhodocyclales	C	ATP synthase I chain	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATP-synt_I
HKD3_k127_7087289_7	1197906.CAJQ02000023_gene2252	2.581e-25	106.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,3JV3U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_09945	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_7087289_4	977880.RALTA_A1464	1.904e-115	379.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VIKW@28216|Betaproteobacteria,1JZVH@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_7087289_2	264198.Reut_A1401	7.638e-168	538.0	COG4177@1|root,COG4177@2|Bacteria,1MY3V@1224|Proteobacteria,2VJIE@28216|Betaproteobacteria,1K0XJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD3_k127_7087289_3	338969.Rfer_2390	7.137e-142	457.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VJAM@28216|Betaproteobacteria,4AANH@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_7087289_1	264198.Reut_A1399	6.961e-187	612.0	COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2VI1S@28216|Betaproteobacteria,1K1YI@119060|Burkholderiaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_7087289_5	1218076.BAYB01000006_gene1083	1.047e-95	324.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_7087289_6	1268622.AVS7_00223	1.894e-28	115.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2VVV9@28216|Betaproteobacteria,4AFPU@80864|Comamonadaceae	28216|Betaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD3_k127_7087289_0	864051.BurJ1DRAFT_3299	0.0	1463.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KJIC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_7087289_8	1276756.AUEX01000015_gene2009	7.844e-14	74.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VJAC@28216|Betaproteobacteria,4AAHF@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD3_k127_7264444_8	1121861.KB899912_gene1051	2.753e-61	217.0	COG1028@1|root,COG1028@2|Bacteria,1PP5H@1224|Proteobacteria,2TTQV@28211|Alphaproteobacteria,2JPMX@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_7264444_0	62928.azo0472	1.651e-209	662.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KV3P@206389|Rhodocyclales	206389|Rhodocyclales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_7264444_3	420662.Mpe_A3382	5.135e-138	454.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2VIRM@28216|Betaproteobacteria,1KMM7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,p450
HKD3_k127_7264444_13	1267534.KB906756_gene712	7.355e-34	139.0	2A3BS@1|root,30RTX@2|Bacteria,3Y943@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7264444_5	358220.C380_23415	3.383e-84	285.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2VQ0V@28216|Betaproteobacteria,4ADY5@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM flavin reductase domain protein, FMN-binding	flr	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD3_k127_7264444_6	292415.Tbd_2287	3.173e-76	267.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,2VQQJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
HKD3_k127_7264444_14	756272.Plabr_1849	4.258e-08	64.0	COG5126@1|root,COG5126@2|Bacteria	2|Bacteria	DTZ	Ca2 -binding protein (EF-Hand superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD3_k127_7264444_12	1248916.ANFY01000007_gene2527	2.329e-35	142.0	2DMP1@1|root,32SS8@2|Bacteria,1N0XZ@1224|Proteobacteria,2UBZ9@28211|Alphaproteobacteria,2K5H8@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0311 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
HKD3_k127_7264444_2	1097668.BYI23_B007110	5.029e-154	493.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,1K352@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_7264444_9	269482.Bcep1808_0306	1.527e-52	192.0	COG1309@1|root,COG1309@2|Bacteria,1QYD4@1224|Proteobacteria,2VMMD@28216|Betaproteobacteria,1K2K8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	paaR	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HKD3_k127_7264444_1	93220.LV28_13240	6.14e-170	542.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2VKK1@28216|Betaproteobacteria,1JZVV@119060|Burkholderiaceae	28216|Betaproteobacteria	C	TIGRFAM phenylacetate-CoA oxygenase reductase, PaaK subunit	paaE	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_7264444_11	1123504.JQKD01000013_gene1021	1.516e-45	182.0	COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,2VQI0@28216|Betaproteobacteria,4AE5G@80864|Comamonadaceae	28216|Betaproteobacteria	L	TIGRFAM phenylacetate-CoA oxygenase, PaaJ subunit	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HKD3_k127_7264444_4	1235457.C404_06095	2.967e-95	322.0	COG3396@1|root,COG3396@2|Bacteria,1MVYQ@1224|Proteobacteria,2VJ03@28216|Betaproteobacteria,1K1P5@119060|Burkholderiaceae	28216|Betaproteobacteria	S	phenylacetic acid	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD3_k127_7264444_10	1169143.KB911048_gene5384	9.606e-50	178.0	COG3460@1|root,COG3460@2|Bacteria,1RHM5@1224|Proteobacteria,2VSR2@28216|Betaproteobacteria,1K8BF@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Phenylacetic acid degradation	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
HKD3_k127_7264444_7	264198.Reut_A3206	4.114e-68	233.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2VHQZ@28216|Betaproteobacteria,1K0CX@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM phenylacetic acid catabolic family protein	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD3_k127_7264832_1	1504672.669783908	2.045e-190	626.0	COG0179@1|root,COG0179@2|Bacteria,1MW82@1224|Proteobacteria,2VJAE@28216|Betaproteobacteria,4ACVI@80864|Comamonadaceae	28216|Betaproteobacteria	Q	fumarylacetoacetate (FAA) hydrolase	fahA	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HKD3_k127_7264832_5	887898.HMPREF0551_0367	3.279e-153	495.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,1K3FF@119060|Burkholderiaceae	28216|Betaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD3_k127_7264832_14	887898.HMPREF0551_0366	9.511e-53	190.0	COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,2VRJ4@28216|Betaproteobacteria,1K0EI@119060|Burkholderiaceae	28216|Betaproteobacteria	G	peptidyl-prolyl cis-trans isomerase	fkpB	-	5.2.1.8	ko:K03774	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD3_k127_7264832_13	580332.Slit_0752	8.661e-69	243.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2VKTW@28216|Betaproteobacteria,44VW9@713636|Nitrosomonadales	28216|Betaproteobacteria	L	RadC-like JAB domain	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD3_k127_7264832_17	882378.RBRH_00923	8.934e-35	147.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2VU1B@28216|Betaproteobacteria,1K9CB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD3_k127_7264832_18	882378.RBRH_00925	1.091e-23	100.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2VVW8@28216|Betaproteobacteria,1KA4N@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD3_k127_7264832_7	1282876.BAOK01000001_gene1844	1.055e-116	381.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_7264832_3	1095769.CAHF01000007_gene1691	2.6e-173	552.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VHRS@28216|Betaproteobacteria,472Q2@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Transposase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	DDE_Tnp_ISL3,FA_desaturase
HKD3_k127_7264832_10	1454004.AW11_03464	2.584e-83	304.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,1KQDU@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Mechanosensitive ion channel	aefA	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD3_k127_7264832_8	1158292.JPOE01000002_gene3169	4.257e-115	387.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2VI1D@28216|Betaproteobacteria,1KIZZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB_2	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
HKD3_k127_7264832_11	62928.azo3124	4.441e-82	278.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2VJG8@28216|Betaproteobacteria,2KVYQ@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD3_k127_7264832_9	266264.Rmet_2884	4.492e-114	376.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,1JZTJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD3_k127_7264832_0	1095769.CAHF01000011_gene2717	0.0	1472.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,473U5@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD3_k127_7264832_15	391038.Bphy_0573	9.785e-53	214.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,1K1IQ@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD3_k127_7264832_4	977880.RALTA_A2523	1.099e-165	530.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2VI4X@28216|Betaproteobacteria,1K09K@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD3_k127_7264832_12	859657.RPSI07_1011	2.069e-69	237.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2VQ5I@28216|Betaproteobacteria,1K6Z7@119060|Burkholderiaceae	28216|Betaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD3_k127_7264832_6	757424.Hsero_1096	2.47e-127	435.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,4731M@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD3_k127_7264832_2	305700.B447_05353	1.215e-186	587.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,2KV8P@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rmlB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD3_k127_7264832_16	1163617.SCD_n02912	2.932e-35	134.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_7277507_2	1437824.BN940_02506	7.48e-178	563.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2VJUH@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD3_k127_7277507_10	62928.azo3680	1.823e-19	104.0	2E3JP@1|root,32YI0@2|Bacteria,1N6ZI@1224|Proteobacteria,2VWGY@28216|Betaproteobacteria,2KZ6J@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2783
HKD3_k127_7277507_0	748247.AZKH_4363	2.206e-259	810.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VI73@28216|Betaproteobacteria,2KYGN@206389|Rhodocyclales	206389|Rhodocyclales	C	FAD binding domain	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD3_k127_7277507_7	62928.azo3683	8.266e-87	293.0	COG1414@1|root,COG1414@2|Bacteria,1Q7BI@1224|Proteobacteria,2VK7Y@28216|Betaproteobacteria,2KW6Q@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD3_k127_7277507_8	1123367.C666_06570	3.89e-72	249.0	COG0663@1|root,COG0663@2|Bacteria,1MVUI@1224|Proteobacteria,2VH4Y@28216|Betaproteobacteria,2KUST@206389|Rhodocyclales	206389|Rhodocyclales	S	Phenylacetic acid degradation protein PaaY	-	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
HKD3_k127_7277507_1	1123393.KB891316_gene1685	5.613e-227	711.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,1KRE8@119069|Hydrogenophilales	119069|Hydrogenophilales	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD3_k127_7277507_9	1123393.KB891316_gene1686	5.806e-55	197.0	COG0617@1|root,COG1371@1|root,COG0617@2|Bacteria,COG1371@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease,HD,PolyA_pol,PolyA_pol_RNAbd
HKD3_k127_7277507_4	1095769.CAHF01000005_gene1493	1.026e-140	469.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2VKB5@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_7277507_5	1110502.TMO_2422	2.934e-121	423.0	COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria,2JW6C@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_7277507_6	522306.CAP2UW1_1263	2.379e-117	394.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,1KQFS@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD3_k127_7277507_3	1175306.GWL_20280	1.658e-166	530.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,473RQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	AMP-binding enzyme	paaK_2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD3_k127_7281496_9	640511.BC1002_6280	6.085e-177	555.0	COG2235@1|root,COG2235@2|Bacteria,1NCGV@1224|Proteobacteria,2VP2J@28216|Betaproteobacteria,1K2U4@119060|Burkholderiaceae	28216|Betaproteobacteria	E	arginine	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
HKD3_k127_7281496_17	1121127.JAFA01000002_gene1565	3.236e-96	336.0	COG0845@1|root,COG0845@2|Bacteria,1NJDF@1224|Proteobacteria,2VIS6@28216|Betaproteobacteria,1KBZU@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD3_k127_7281496_0	1121127.JAFA01000002_gene1564	0.0	1399.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria,1K0BK@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_7281496_11	1121127.JAFA01000058_gene3046	3.005e-172	554.0	COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,2VKRN@28216|Betaproteobacteria,1KCQK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
HKD3_k127_7281496_15	768671.ThimaDRAFT_1335	5.971e-112	380.0	COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1WY7I@135613|Chromatiales	135613|Chromatiales	M	PFAM phospholipase A1	-	-	3.1.1.32,3.1.1.4	ko:K01058	ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110	-	R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko01000	-	-	-	PLA1
HKD3_k127_7281496_27	1121127.JAFA01000002_gene1563	3.318e-47	176.0	COG1863@1|root,COG1863@2|Bacteria,1N7MB@1224|Proteobacteria,2W7Z2@28216|Betaproteobacteria,1KCPM@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Na+/H+ ion antiporter subunit	-	-	-	-	-	-	-	-	-	-	-	-	MNHE
HKD3_k127_7281496_33	622637.KE124774_gene2190	8.975e-13	77.0	COG2212@1|root,COG2212@2|Bacteria,1N90U@1224|Proteobacteria	1224|Proteobacteria	P	Multiple resistance and pH regulation protein F	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
HKD3_k127_7281496_29	1038860.AXAP01000001_gene6335	2.085e-29	124.0	COG1320@1|root,COG1320@2|Bacteria,1N75I@1224|Proteobacteria,2UETR@28211|Alphaproteobacteria,3K0FE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Na+/H+ antiporter subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
HKD3_k127_7281496_14	1121127.JAFA01000002_gene1560	1.642e-116	389.0	COG1563@1|root,COG1563@2|Bacteria,1RB3N@1224|Proteobacteria,2W6RN@28216|Betaproteobacteria,1KCFC@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Domain of unknown function (DUF4040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4040,MnhB
HKD3_k127_7281496_28	443598.AUFA01000006_gene3500	1.68e-31	139.0	COG1006@1|root,COG1006@2|Bacteria,1N7TX@1224|Proteobacteria,2UHUU@28211|Alphaproteobacteria,3JZES@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
HKD3_k127_7281496_10	1038860.AXAP01000001_gene6332	2.242e-175	567.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,3JSAF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD3_k127_7281496_19	765911.Thivi_1393	2.222e-89	315.0	2EX9F@1|root,33QK5@2|Bacteria,1NSHW@1224|Proteobacteria,1SKS4@1236|Gammaproteobacteria,1X0DS@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7281496_13	633.DJ40_4179	1.194e-128	423.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria,41ETQ@629|Yersinia	1236|Gammaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD3_k127_7281496_7	1121127.JAFA01000002_gene1556	8.201e-182	583.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KCHF@119060|Burkholderiaceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD3_k127_7281496_20	1120999.JONM01000013_gene2196	4.732e-85	304.0	COG3965@1|root,COG3965@2|Bacteria,1MXVG@1224|Proteobacteria	1224|Proteobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HKD3_k127_7281496_25	204669.Acid345_4051	1.767e-60	223.0	2CAM1@1|root,301FE@2|Bacteria,3Y87M@57723|Acidobacteria	57723|Acidobacteria	S	Ceramidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7281496_5	614083.AWQR01000053_gene3394	5.475e-203	641.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,4A9Y2@80864|Comamonadaceae	28216|Betaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD3_k127_7281496_2	614083.AWQR01000053_gene3395	0.0	1078.0	COG5322@1|root,COG5322@2|Bacteria,1R60X@1224|Proteobacteria	1224|Proteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Semialdhyde_dh
HKD3_k127_7281496_26	189753.AXAS01000085_gene6037	1.207e-56	209.0	COG3637@1|root,COG3637@2|Bacteria,1QUBN@1224|Proteobacteria,2TVCZ@28211|Alphaproteobacteria,3JUEC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7281496_16	522306.CAP2UW1_2397	7.144e-105	376.0	28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,2VS45@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7281496_8	1123504.JQKD01000027_gene4088	1.98e-180	569.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2VIUC@28216|Betaproteobacteria,4AC4C@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD3_k127_7281496_4	1038860.AXAP01000008_gene5969	1.013e-264	824.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2UQJ2@28211|Alphaproteobacteria,3K2BQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	HpaB,HpaB_N
HKD3_k127_7281496_23	1005048.CFU_1375	5.058e-65	230.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria,47412@75682|Oxalobacteraceae	28216|Betaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33,3.8.1.5	ko:K01563,ko:K11991	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223	RC00477,RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000,ko03016	-	-	-	Abhydrolase_1,MafB19-deam,TfoX_C
HKD3_k127_7281496_18	887898.HMPREF0551_0677	1.947e-92	311.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,1K1DK@119060|Burkholderiaceae	28216|Betaproteobacteria	M	peptidylprolyl isomerase	cbf2	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N_3
HKD3_k127_7281496_30	887898.HMPREF0551_0678	2.907e-28	124.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,1K8DM@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Belongs to the BolA IbaG family	bolA	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
HKD3_k127_7281496_21	1366050.N234_07560	4.768e-70	241.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,1K076@119060|Burkholderiaceae	28216|Betaproteobacteria	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD3_k127_7281496_34	937774.TEQUI_0338	6.455e-10	60.0	28ZT2@1|root,2ZMHR@2|Bacteria,1PK44@1224|Proteobacteria,2W8EP@28216|Betaproteobacteria,3T52K@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7281496_24	29581.BW37_04387	3.662e-62	218.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2VSHQ@28216|Betaproteobacteria,4745V@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD3_k127_7281496_6	395019.Bmul_1366	1.909e-202	649.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2VH7S@28216|Betaproteobacteria,1K1NK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the UPF0061 (SELO) family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
HKD3_k127_7281496_3	1095769.CAHF01000011_gene2102	4.343e-269	839.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,472TV@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	alkK	-	6.2.1.44	ko:K00666,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7281496_31	1123487.KB892868_gene1108	1.877e-25	122.0	COG0640@1|root,COG0640@2|Bacteria,1Q9DY@1224|Proteobacteria,2VVWF@28216|Betaproteobacteria,2KXM8@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD3_k127_7281496_22	365044.Pnap_2827	3.221e-67	243.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VJAC@28216|Betaproteobacteria,4AAHF@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD3_k127_7281496_1	864051.BurJ1DRAFT_3299	0.0	1356.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KJIC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_7281496_12	1122604.JONR01000057_gene3541	1.227e-144	497.0	COG0446@1|root,COG0446@2|Bacteria,1QUQF@1224|Proteobacteria,1RP1H@1236|Gammaproteobacteria,1X5BD@135614|Xanthomonadales	135614|Xanthomonadales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_7299034_32	477184.KYC_25032	1.352e-09	61.0	COG1028@1|root,COG1028@2|Bacteria,1PP5H@1224|Proteobacteria,2VJ4Y@28216|Betaproteobacteria,3T2MY@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_7299034_17	1123367.C666_14400	3.133e-66	233.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,2KWFV@206389|Rhodocyclales	206389|Rhodocyclales	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD3_k127_7299034_6	1198452.Jab_2c16790	3.191e-119	416.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2VIRM@28216|Betaproteobacteria,47806@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,p450
HKD3_k127_7299034_3	760117.JN27_01130	1.77e-134	460.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2VGZX@28216|Betaproteobacteria,475T3@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_7299034_5	1218084.BBJK01000020_gene2126	2.161e-122	415.0	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2VIMS@28216|Betaproteobacteria,1K0A8@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA15	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_7299034_29	388051.AUFE01000024_gene4656	1.685e-22	109.0	2EDY7@1|root,30V4M@2|Bacteria,1RGIS@1224|Proteobacteria,2VQT2@28216|Betaproteobacteria,1K4HU@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7299034_12	987059.RBXJA2T_19034	3.339e-87	307.0	COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,2VIY7@28216|Betaproteobacteria,1KJ2J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	FIST_C	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
HKD3_k127_7299034_8	420662.Mpe_A0238	2.978e-104	352.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,1KJT9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD3_k127_7299034_16	388051.AUFE01000024_gene4706	3.113e-66	232.0	COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,2VQHV@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
HKD3_k127_7299034_0	29581.BW37_01197	2.397e-152	493.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,475TQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
HKD3_k127_7299034_11	987059.RBXJA2T_02712	3.984e-89	301.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,1KJ9C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
HKD3_k127_7299034_4	1286631.X805_02050	1.706e-130	457.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,1KJWP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD3_k127_7299034_26	29581.BW37_01194	1.445e-36	158.0	COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria,2VUCP@28216|Betaproteobacteria,477A8@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
HKD3_k127_7299034_10	204773.HEAR2425	2.505e-96	340.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2VI47@28216|Betaproteobacteria,475BN@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
HKD3_k127_7299034_9	243365.CV_3227	5.035e-101	346.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2VH63@28216|Betaproteobacteria,2KQP2@206351|Neisseriales	206351|Neisseriales	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_7299034_18	983917.RGE_44970	8.463e-52	188.0	COG3631@1|root,COG3631@2|Bacteria,1MZS5@1224|Proteobacteria,2VSD2@28216|Betaproteobacteria,1KM0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	SnoaL_2
HKD3_k127_7299034_1	987059.RBXJA2T_02697	6.811e-151	485.0	COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,2VI3H@28216|Betaproteobacteria,1KJG3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7299034_22	887062.HGR_03287	8.094e-48	189.0	COG4315@1|root,COG4315@2|Bacteria,1MZC6@1224|Proteobacteria,2VU7D@28216|Betaproteobacteria,4AEXB@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Secreted repeat of	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HKD3_k127_7299034_23	159087.Daro_0521	1.134e-41	162.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VSEK@28216|Betaproteobacteria,2KWUW@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_7299034_20	29581.BW37_03573	1.046e-50	198.0	COG5662@1|root,COG5662@2|Bacteria,1RK1X@1224|Proteobacteria,2VQDP@28216|Betaproteobacteria,472NC@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	transmembrane transcriptional regulator (Anti-sigma factor)	prtR	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD3_k127_7299034_15	62928.azo3305	1.875e-67	246.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,2KW34@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	2.7.7.70	ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_7299034_28	1095769.CAHF01000005_gene1527	1.645e-23	114.0	COG2105@1|root,COG2105@2|Bacteria,1NEI1@1224|Proteobacteria,2W3FC@28216|Betaproteobacteria,477M4@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
HKD3_k127_7299034_33	983917.RGE_44750	1.45e-06	62.0	2DD05@1|root,2ZG0C@2|Bacteria,1RC2B@1224|Proteobacteria,2VQ0R@28216|Betaproteobacteria,1KM8Y@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Sporulation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7299034_25	1415780.JPOG01000001_gene2716	4.874e-38	155.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1X4H7@135614|Xanthomonadales	135614|Xanthomonadales	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD3_k127_7299034_19	1304883.KI912532_gene873	2.277e-51	203.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,2KW9S@206389|Rhodocyclales	206389|Rhodocyclales	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD3_k127_7299034_24	266264.Rmet_0227	9.666e-39	168.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,2VTY1@28216|Betaproteobacteria,1K7RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxin	fdx	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HKD3_k127_7299034_13	388051.AUFE01000013_gene2698	9.244e-72	254.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,1K1NE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
HKD3_k127_7299034_31	935863.AWZR01000005_gene2426	1.336e-09	68.0	2E56W@1|root,33I8C@2|Bacteria,1NIND@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7299034_2	887898.HMPREF0551_2010	2.276e-146	482.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,1K1FK@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD3_k127_7299034_7	887898.HMPREF0551_2011	1.337e-117	384.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,1K3DX@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	PFAM aminotransferase, class IV	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
HKD3_k127_7299034_27	1123487.KB892834_gene2779	3.228e-25	108.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,2KWZM@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
HKD3_k127_7299034_21	1380390.JIAT01000016_gene5574	2e-49	191.0	COG0697@1|root,COG0697@2|Bacteria,2IHCX@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_7299034_14	1286631.X805_02280	4.12e-68	251.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2VQ1Y@28216|Betaproteobacteria,1KK26@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD3_k127_7314825_30	1192124.LIG30_3568	2.321e-35	146.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,1K0NM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	UPF0761 membrane protein	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD3_k127_7314825_31	887898.HMPREF0551_0878	2e-25	113.0	COG3308@1|root,COG3308@2|Bacteria,1N1EF@1224|Proteobacteria,2VU3C@28216|Betaproteobacteria,1K8ZZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2069
HKD3_k127_7314825_18	640081.Dsui_2821	1.535e-97	330.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,2WEJI@28216|Betaproteobacteria,2KUP5@206389|Rhodocyclales	206389|Rhodocyclales	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
HKD3_k127_7314825_11	365046.Rta_18130	9.782e-136	445.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2VHCA@28216|Betaproteobacteria,4A9MT@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD3_k127_7314825_29	1000565.METUNv1_01904	2.688e-42	168.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,2KW82@206389|Rhodocyclales	28216|Betaproteobacteria	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	epsR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_7314825_26	1149133.ppKF707_0910	1.199e-49	194.0	COG1960@1|root,COG1960@2|Bacteria,1NQAE@1224|Proteobacteria,1S5VG@1236|Gammaproteobacteria,1YIVN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
HKD3_k127_7314825_7	123899.JPQP01000004_gene650	2.729e-150	484.0	COG1960@1|root,COG1960@2|Bacteria,1MW0F@1224|Proteobacteria,2VH0B@28216|Betaproteobacteria,3T2AQ@506|Alcaligenaceae	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_7314825_28	445970.ALIPUT_01672	1.423e-42	179.0	COG1597@1|root,COG1597@2|Bacteria,4NGPY@976|Bacteroidetes,2FP27@200643|Bacteroidia,22U5U@171550|Rikenellaceae	976|Bacteroidetes	I	lipid kinase, YegS Rv2252 BmrU family	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD3_k127_7314825_8	945713.IALB_1980	1.457e-142	463.0	COG0205@1|root,COG0205@2|Bacteria	2|Bacteria	G	6-phosphofructokinase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	iJN678.pfkA	PFK
HKD3_k127_7314825_17	1095769.CAHF01000008_gene3652	1.132e-100	338.0	COG3687@1|root,COG3687@2|Bacteria,1RBP4@1224|Proteobacteria,2WFRM@28216|Betaproteobacteria,474EX@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
HKD3_k127_7314825_23	266264.Rmet_4196	2.046e-74	258.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria,1KH3S@119060|Burkholderiaceae	28216|Betaproteobacteria	G	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_7314825_12	1121127.JAFA01000008_gene5943	3.79e-123	400.0	COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,2VIQH@28216|Betaproteobacteria,1K4BI@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_7314825_5	864051.BurJ1DRAFT_4617	2.928e-204	653.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VNJ6@28216|Betaproteobacteria,1KN3N@119065|unclassified Burkholderiales	1224|Proteobacteria	E	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HKD3_k127_7314825_25	987059.RBXJA2T_18728	9.162e-57	227.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2VSZI@28216|Betaproteobacteria,1KMJD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD3_k127_7314825_1	414684.RC1_0300	4.784e-294	929.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2JUZE@204441|Rhodospirillales	204441|Rhodospirillales	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD3_k127_7314825_6	59538.XP_005977051.1	4.919e-163	524.0	COG0031@1|root,KOG1252@2759|Eukaryota,38B7H@33154|Opisthokonta,3BBJK@33208|Metazoa,3CY68@33213|Bilateria,488CX@7711|Chordata,48W7H@7742|Vertebrata,3J8K4@40674|Mammalia	33208|Metazoa	E	cysteine biosynthetic process from serine	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_7314825_22	1205680.CAKO01000002_gene2632	8.992e-83	286.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,2VFWY@28211|Alphaproteobacteria,2JT1S@204441|Rhodospirillales	204441|Rhodospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_7314825_2	93220.LV28_14100	7.14e-281	875.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHAT@28216|Betaproteobacteria,1K3JE@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7314825_13	1003200.AXXA_03234	1.027e-119	419.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,3T5JR@506|Alcaligenaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD3_k127_7314825_4	398578.Daci_4800	5.917e-238	749.0	COG1178@1|root,COG1178@2|Bacteria,1R0MN@1224|Proteobacteria,2VK7P@28216|Betaproteobacteria,4AD6E@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD3_k127_7314825_10	1123366.TH3_19982	6.074e-139	455.0	COG1840@1|root,COG1840@2|Bacteria,1MWWI@1224|Proteobacteria,2VF0S@28211|Alphaproteobacteria,2JYNS@204441|Rhodospirillales	204441|Rhodospirillales	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_6
HKD3_k127_7314825_3	1205680.CAKO01000002_gene2647	4.496e-243	760.0	COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TRRZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	MA20_06755	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7314825_15	864051.BurJ1DRAFT_3792	5.655e-103	343.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,2VI8F@28216|Betaproteobacteria,1KMW9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD3_k127_7314825_9	1205680.CAKO01000029_gene5263	4.496e-139	447.0	COG1028@1|root,COG1028@2|Bacteria,1MXFZ@1224|Proteobacteria,2TQZ9@28211|Alphaproteobacteria,2JRAG@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_7314825_32	266117.Rxyl_2877	1.334e-14	80.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	ywlB	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7,C_GCAxxG_C_C
HKD3_k127_7314825_27	264198.Reut_B3516	1.898e-44	167.0	2DRHM@1|root,32UR4@2|Bacteria,1RCYI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7314825_16	402881.Plav_3076	1.381e-102	347.0	COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,2TRMW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	MA20_16375	-	-	-	-	-	-	-	-	-	-	-	APH
HKD3_k127_7314825_14	1429916.X566_23820	4.4e-113	370.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,3JU3S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the GST superfamily	MA20_32390	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_3,GST_N
HKD3_k127_7314825_20	338969.Rfer_2632	1.919e-89	312.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQJ1@28216|Betaproteobacteria,4AJTE@80864|Comamonadaceae	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
HKD3_k127_7314825_24	1476583.DEIPH_ctg032orf0049	4.144e-66	231.0	COG2080@1|root,COG2080@2|Bacteria,1WK3N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD3_k127_7314825_0	1157708.KB907450_gene6147	0.0	1047.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4ABN8@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD3_k127_7314825_19	864051.BurJ1DRAFT_4908	8.659e-97	324.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VHV8@28216|Betaproteobacteria,1KN3C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	coxM	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD3_k127_7314825_21	113395.AXAI01000009_gene2369	8.59e-85	288.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2TSQC@28211|Alphaproteobacteria,3JV19@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	MA20_16655	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,DUF676,Hydrolase_4
HKD3_k127_7341276_5	1205680.CAKO01000010_gene3929	1.948e-97	332.0	COG3618@1|root,COG3618@2|Bacteria,1QWWJ@1224|Proteobacteria,2TV8V@28211|Alphaproteobacteria,2JVWZ@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7341276_6	292415.Tbd_1408	6.372e-40	158.0	COG2920@1|root,COG2920@2|Bacteria,1N3YM@1224|Proteobacteria,2W3KZ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	DsrC like protein	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
HKD3_k127_7341276_4	1205680.CAKO01000010_gene3927	1.575e-113	384.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,2JR9Q@204441|Rhodospirillales	204441|Rhodospirillales	P	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD3_k127_7341276_7	987059.RBXJA2T_08760	1.008e-17	88.0	COG2331@1|root,COG2331@2|Bacteria,1PVEY@1224|Proteobacteria,2VYJG@28216|Betaproteobacteria,1KP71@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD3_k127_7341276_3	420662.Mpe_A1621	2.703e-123	409.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VKJ3@28216|Betaproteobacteria,1KIWH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1
HKD3_k127_7341276_1	94624.Bpet3600	7.022e-196	615.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,3T1MN@506|Alcaligenaceae	28216|Betaproteobacteria	G	catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD3_k127_7341276_0	887898.HMPREF0551_0239	7.965e-226	722.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,1K3DK@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD3_k127_7341276_2	264198.Reut_A0559	5.031e-142	454.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,1K22I@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD3_k127_7369515_4	983917.RGE_29120	1.051e-172	550.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1KJ43@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_7369515_19	1217718.ALOU01000007_gene1345	9.61e-27	114.0	COG1585@1|root,COG1585@2|Bacteria,1N474@1224|Proteobacteria,2VWDX@28216|Betaproteobacteria,1K7AI@119060|Burkholderiaceae	28216|Betaproteobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HKD3_k127_7369515_7	257313.BP1440	4.016e-144	464.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,3T1QY@506|Alcaligenaceae	28216|Betaproteobacteria	O	Membrane protease subunits, stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
HKD3_k127_7369515_5	1163617.SCD_n00481	1.92e-157	518.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria	28216|Betaproteobacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HKD3_k127_7369515_17	292415.Tbd_0089	3.569e-43	166.0	COG0847@1|root,COG0847@2|Bacteria,1RCPS@1224|Proteobacteria,2WEVE@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_7369515_12	977880.RALTA_A1671	1.762e-70	241.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,1K07V@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD3_k127_7369515_18	1144342.PMI40_03565	5.436e-43	164.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,47453@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Oligoketide cyclase lipid transport protein	ratA	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD3_k127_7369515_25	1121013.P873_00200	5.986e-08	62.0	COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1X84S@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the UPF0125 (RnfH) family	-	-	-	ko:K09801	-	-	-	-	ko00000	-	-	-	Ub-RnfH
HKD3_k127_7369515_22	420662.Mpe_A1619	1.297e-17	94.0	2BCK1@1|root,32662@2|Bacteria,1RHH4@1224|Proteobacteria,2VSPG@28216|Betaproteobacteria,1KMDU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HKD3_k127_7369515_2	360910.BAV1567	2.088e-246	769.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,3T2KH@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD3_k127_7369515_1	1218074.BAXZ01000003_gene731	4.892e-277	859.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,1K4BU@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD3_k127_7369515_14	441620.Mpop_3112	2.188e-55	199.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2U05W@28211|Alphaproteobacteria,1JVAT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
HKD3_k127_7369515_24	1411123.JQNH01000001_gene1479	1.261e-13	74.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
HKD3_k127_7369515_3	469383.Cwoe_4226	2.072e-228	719.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4CRRH@84995|Rubrobacteria	84995|Rubrobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_7369515_23	1088721.NSU_3513	1.228e-14	82.0	2AES6@1|root,301C8@2|Bacteria,1NY4K@1224|Proteobacteria,2USRE@28211|Alphaproteobacteria,2KAR3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7369515_11	388051.AUFE01000047_gene2473	5.378e-82	285.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_7369515_8	748247.AZKH_1973	4.084e-138	459.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,2WFUK@28216|Betaproteobacteria,2KXC6@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD3_k127_7369515_16	443144.GM21_1236	1.187e-44	177.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,43TVR@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD3_k127_7369515_0	748247.AZKH_1971	0.0	1427.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD3_k127_7369515_10	748247.AZKH_1970	3.271e-117	383.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2VH8R@28216|Betaproteobacteria,2KVXS@206389|Rhodocyclales	1224|Proteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100,1.1.1.36	ko:K00023,ko:K00059	ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00373,M00572	R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00103,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD3_k127_7369515_13	1157708.KB907457_gene2794	9.194e-63	225.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria,2W2QC@28216|Betaproteobacteria,4AHQC@80864|Comamonadaceae	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_7369515_6	1038862.KB893895_gene7155	1.988e-149	484.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VFW2@28211|Alphaproteobacteria,3JTF9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	MA20_16675	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD3_k127_7369515_26	1157708.KB907457_gene2792	9.424e-08	62.0	2DSEU@1|root,33FV9@2|Bacteria,1RG4E@1224|Proteobacteria	1224|Proteobacteria	S	polyhydroxyalkanoic acid synthase, PhaR subunit	-	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
HKD3_k127_7369515_20	1538295.JY96_08510	2.755e-26	115.0	COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,2VPD9@28216|Betaproteobacteria,1KKY3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD3_k127_7369515_21	395495.Lcho_2166	1.249e-19	101.0	COG2146@1|root,COG2146@2|Bacteria,1N82Y@1224|Proteobacteria,2VX8W@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD3_k127_7369515_9	388051.AUFE01000094_gene31	3.527e-120	391.0	COG1028@1|root,COG1028@2|Bacteria,1NYXI@1224|Proteobacteria,2VPQD@28216|Betaproteobacteria,1K2B2@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_7369515_15	1217718.ALOU01000007_gene1246	1.343e-47	174.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2VZMS@28216|Betaproteobacteria,1KGJI@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_7454584_0	987059.RBXJA2T_15792	3.063e-229	726.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,2VNQM@28216|Betaproteobacteria,1KJVS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
HKD3_k127_7454584_3	1131553.JIBI01000006_gene1123	0.0002093	49.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,373F7@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Cytochrome c, class I	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_7454584_1	338969.Rfer_2479	3.128e-228	728.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,4AG8M@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD3_k127_7454584_2	661478.OP10G_4260	6.122e-95	328.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD3_k127_7463091_5	1100720.ALKN01000033_gene730	1.045e-169	552.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,4AB9R@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_7463091_9	1100720.ALKN01000033_gene729	1.86e-115	378.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2VJA0@28216|Betaproteobacteria,4ABV2@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_7463091_7	1100720.ALKN01000033_gene728	1.429e-131	423.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VJN5@28216|Betaproteobacteria,4AACW@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	drrA	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_7463091_18	396588.Tgr7_1414	2.006e-14	78.0	2ETEI@1|root,33KYE@2|Bacteria,1NJKD@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7463091_1	398527.Bphyt_6403	6.454e-306	947.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VK0D@28216|Betaproteobacteria,1K416@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD3_k127_7463091_6	1031711.RSPO_c00684	8.602e-142	462.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,1K2BJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	CBS domain containing protein	corB	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD3_k127_7463091_2	887898.HMPREF0551_1786	1.601e-258	818.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,1K2FT@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02454,ko:K02504,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HKD3_k127_7463091_3	887898.HMPREF0551_1787	7.834e-190	601.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,1K2EB@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD3_k127_7463091_10	1304883.KI912532_gene1506	1.811e-113	380.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,2KVU7@206389|Rhodocyclales	206389|Rhodocyclales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD3_k127_7463091_14	1458357.BG58_35565	3.971e-68	240.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2VR8K@28216|Betaproteobacteria,1K2YJ@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD3_k127_7463091_12	1095769.CAHF01000014_gene2895	6.996e-101	336.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,472DG@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
HKD3_k127_7463091_19	644801.Psest_3284	6.001e-14	80.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,1Z3G8@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD3_k127_7463091_16	1095769.CAHF01000015_gene2791	6.233e-49	185.0	COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VVH4@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD3_k127_7463091_13	1157708.KB907464_gene482	3.182e-69	252.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2VQD1@28216|Betaproteobacteria,4ACGY@80864|Comamonadaceae	28216|Betaproteobacteria	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD3_k127_7463091_15	1163617.SCD_n02471	2.282e-51	204.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,TMP-TENI
HKD3_k127_7463091_8	1005048.CFU_3929	2.73e-124	431.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,4723U@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ATPase (AAA superfamily)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD3_k127_7463091_4	426114.THI_0411	3.597e-175	557.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1KJ4N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD3_k127_7463091_11	314345.SPV1_12622	2.933e-102	366.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria	1224|Proteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
HKD3_k127_7463091_17	1082933.MEA186_33654	6.977e-28	122.0	COG3254@1|root,COG3254@2|Bacteria,1RIRS@1224|Proteobacteria,2UAT0@28211|Alphaproteobacteria,43QBK@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	rhamnose metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD3_k127_7463091_0	1392838.AWNM01000023_gene3894	0.0	1362.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,3T1D5@506|Alcaligenaceae	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD3_k127_7513265_1	1217718.ALOU01000037_gene2033	3.062e-118	387.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,1K6J1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	zinc protease protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
HKD3_k127_7513265_0	1095769.CAHF01000001_gene3559	7.252e-273	849.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,473Q4@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7513265_2	1007105.PT7_0156	1.762e-83	283.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria,3T1WH@506|Alcaligenaceae	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metC	-	2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8	ko:K01739,ko:K01758,ko:K01760,ko:K01761	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD3_k127_7684384_23	375286.mma_1979	3.646e-37	153.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,473QZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	moeA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD3_k127_7684384_19	1000565.METUNv1_04050	6.915e-67	235.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD3_k127_7684384_12	1000565.METUNv1_04051	5.711e-112	386.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD3_k127_7684384_6	1265502.KB905935_gene3084	1.222e-168	547.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4AB8M@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD3_k127_7684384_26	267608.RSc2378	5.067e-28	120.0	2DBXD@1|root,2ZBP6@2|Bacteria,1RB44@1224|Proteobacteria,2VQT3@28216|Betaproteobacteria,1K3GG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
HKD3_k127_7684384_27	267608.RSc2377	2.169e-25	118.0	2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,2VWJH@28216|Betaproteobacteria,1K8AT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
HKD3_k127_7684384_3	375286.mma_1973	2.331e-215	691.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,472MV@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
HKD3_k127_7684384_21	76114.ebA2939	1.952e-52	192.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2VJ39@28216|Betaproteobacteria,2KWS3@206389|Rhodocyclales	206389|Rhodocyclales	S	Chaperone protein TorD	torD	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HKD3_k127_7684384_0	402626.Rpic_2586	0.0	1701.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_7684384_10	864051.BurJ1DRAFT_1324	2.645e-124	399.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,2VJXP@28216|Betaproteobacteria,1KKF1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	fdhB	-	-	ko:K00124,ko:K07307	ko00630,ko00680,ko00920,ko01100,ko01120,ko01200,map00630,map00680,map00920,map01100,map01120,map01200	-	R00519,R09501	RC02555,RC02796	ko00000,ko00001,ko02000	5.A.3.3	-	-	Fer4_11,Fer4_7
HKD3_k127_7684384_33	420662.Mpe_A1172	6.291e-06	57.0	2EIHA@1|root,33C8N@2|Bacteria,1NG9G@1224|Proteobacteria,2VXQQ@28216|Betaproteobacteria,1KMQY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7684384_14	1217718.ALOU01000083_gene2975	1.161e-102	349.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	formate dehydrogenase	fdhC	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD3_k127_7684384_22	296591.Bpro_3554	3.235e-47	193.0	COG2032@1|root,COG2032@2|Bacteria,1N26J@1224|Proteobacteria,2VT83@28216|Betaproteobacteria,4AEKN@80864|Comamonadaceae	28216|Betaproteobacteria	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HKD3_k127_7684384_1	267608.RSc1040	4.052e-286	915.0	COG1530@1|root,COG3266@1|root,COG1530@2|Bacteria,COG3266@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,1K2WP@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD3_k127_7684384_15	882378.RBRH_02605	1.591e-102	351.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,1K2HG@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD3_k127_7684384_18	1121035.AUCH01000001_gene1935	5.536e-67	238.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2VIZ2@28216|Betaproteobacteria,2KVFF@206389|Rhodocyclales	206389|Rhodocyclales	S	HAD-superfamily hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD3_k127_7684384_24	1121035.AUCH01000001_gene1934	6.352e-36	140.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,2KWZ8@206389|Rhodocyclales	206389|Rhodocyclales	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD3_k127_7684384_9	640081.Dsui_2440	3.637e-126	412.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2VH94@28216|Betaproteobacteria,2KVMS@206389|Rhodocyclales	206389|Rhodocyclales	OU	signal peptide peptidase	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD3_k127_7684384_17	266264.Rmet_2435	2.296e-67	240.0	COG0313@1|root,COG0313@2|Bacteria,1RARW@1224|Proteobacteria,2VQ34@28216|Betaproteobacteria,1K2ET@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	rsmI_2	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD3_k127_7684384_20	420662.Mpe_A0633	5.866e-61	216.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,1KKN2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	D	Maf-like protein	yceF	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD3_k127_7684384_29	1286631.X805_21840	2.345e-20	105.0	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,2VUIG@28216|Betaproteobacteria,1KM8F@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD3_k127_7684384_28	1532557.JL37_08535	6.91e-25	118.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,2VVP5@28216|Betaproteobacteria,3T4QE@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD3_k127_7684384_7	1031711.RSPO_c02317	9.792e-129	420.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,1K229@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD3_k127_7684384_8	762376.AXYL_01545	6.535e-128	436.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,3T29J@506|Alcaligenaceae	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD3_k127_7684384_11	257313.BP2442	2.5e-118	391.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,3T1JV@506|Alcaligenaceae	28216|Betaproteobacteria	I	Malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645,ko:K15355	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD3_k127_7684384_13	748247.AZKH_2849	1.801e-104	358.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,2KUFK@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_7684384_25	1159870.KB907784_gene79	2.829e-34	134.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,3T4E2@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD3_k127_7684384_4	398527.Bphyt_2908	8.441e-211	660.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,1K0WZ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817	2.3.1.179	ko:K00646,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_7684384_5	204773.HEAR2068	6.827e-180	587.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4738E@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_7684384_2	1095769.CAHF01000011_gene2051	9.611e-230	716.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,473UZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD3_k127_7684384_16	1072685.IX83_07985	5.086e-87	289.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,3T2QT@506|Alcaligenaceae	28216|Betaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD3_k127_7684384_32	1218084.BBJK01000025_gene2523	1.756e-06	53.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1K263@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD3_k127_7726898_6	1207063.P24_16355	4.762e-120	419.0	COG4177@1|root,COG4177@2|Bacteria,1PAW4@1224|Proteobacteria,2U0EY@28211|Alphaproteobacteria,2JZAV@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_7726898_5	1207063.P24_16360	2.617e-133	430.0	COG0559@1|root,COG0559@2|Bacteria,1R5H9@1224|Proteobacteria,2TUJ6@28211|Alphaproteobacteria,2JVT7@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_7726898_8	331869.BAL199_24464	1.115e-101	349.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,4BT78@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	MA20_02445	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_7726898_7	331869.BAL199_24469	4.05e-114	373.0	COG0411@1|root,COG0411@2|Bacteria,1R7BP@1224|Proteobacteria,2U3BF@28211|Alphaproteobacteria,4BS0A@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_7726898_2	1207063.P24_16375	2.205e-212	666.0	COG0683@1|root,COG0683@2|Bacteria,1Q1P3@1224|Proteobacteria,2TUJG@28211|Alphaproteobacteria,2JVUV@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_7726898_11	1100720.ALKN01000033_gene733	1.799e-81	297.0	COG1917@1|root,COG1917@2|Bacteria,1MUY3@1224|Proteobacteria,2VQRV@28216|Betaproteobacteria,4AE4V@80864|Comamonadaceae	28216|Betaproteobacteria	S	ChrR Cupin-like domain	-	-	1.13.11.41	ko:K05913	ko00363,ko01120,map00363,map01120	-	R01305	RC00415,RC01565	ko00000,ko00001,ko01000	-	-	-	Cupin_2,Cupin_7
HKD3_k127_7726898_4	1163407.UU7_00680	7.929e-145	470.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria,1X4DB@135614|Xanthomonadales	135614|Xanthomonadales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD3_k127_7726898_14	1429851.X548_04295	4.167e-29	126.0	COG3714@1|root,COG3714@2|Bacteria,1N6QN@1224|Proteobacteria,1TAFV@1236|Gammaproteobacteria,1X74T@135614|Xanthomonadales	135614|Xanthomonadales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
HKD3_k127_7726898_9	887898.HMPREF0551_2277	4.133e-94	317.0	COG1573@1|root,COG1573@2|Bacteria,1PIX8@1224|Proteobacteria,2VKZ8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Uracil-DNA glycosylase superfamily	smuG	-	-	ko:K10800	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HKD3_k127_7726898_3	543728.Vapar_0459	6.598e-194	627.0	COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2VJBK@28216|Betaproteobacteria,4ACMD@80864|Comamonadaceae	28216|Betaproteobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7726898_13	1144319.PMI16_03183	1.877e-42	180.0	COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2VSPA@28216|Betaproteobacteria,474BP@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	helix_turn_helix, mercury resistance	zntR	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
HKD3_k127_7726898_12	395495.Lcho_4202	4.896e-47	175.0	COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2VRED@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD3_k127_7726898_1	1095769.CAHF01000005_gene1519	2.243e-220	695.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHD3@28216|Betaproteobacteria,473GR@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	ivd	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_7726898_0	887898.HMPREF0551_2258	9.295e-266	833.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1K440@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
HKD3_k127_7726898_10	1276756.AUEX01000022_gene2564	8.227e-94	319.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,4AAQR@80864|Comamonadaceae	28216|Betaproteobacteria	I	Belongs to the thiolase family	thlA_2	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_7756860_0	381666.H16_A0789	1.931e-315	974.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,1K0UC@119060|Burkholderiaceae	28216|Betaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD3_k127_7756860_2	1089552.KI911559_gene528	2.971e-208	689.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria,2JR5C@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	1.3.8.12	ko:K14448	ko00630,ko01120,ko01200,map00630,map01120,map01200	M00373	R09293	RC02483	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_7756860_7	1336208.JADY01000027_gene2273	2.644e-136	446.0	COG1804@1|root,COG1804@2|Bacteria,1R43P@1224|Proteobacteria,2U1WN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	5.4.1.3	ko:K14470	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09283	RC02480	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD3_k127_7756860_6	1095769.CAHF01000013_gene3276	7.889e-145	475.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,472K2@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	TIGRFAM chorismate mutase domain of proteobacterial P-protein, clade 2	pheA	-	4.2.1.51,4.2.1.91,5.4.99.5	ko:K01713,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD3_k127_7756860_4	402626.Rpic_0775	7.158e-168	534.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,1K2E3@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC2	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_7756860_11	1380387.JADM01000008_gene1020	1.302e-56	210.0	COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1XIJ8@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	1.3.1.12,2.5.1.19	ko:K00210,ko:K00800	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025	R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
HKD3_k127_7756860_16	267608.RSc0591	2.467e-10	74.0	2E7II@1|root,3320V@2|Bacteria,1N91Y@1224|Proteobacteria,2VW18@28216|Betaproteobacteria,1K8QZ@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7756860_3	519989.ECTPHS_08261	3.635e-187	598.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD3_k127_7756860_10	1123392.AQWL01000001_gene1640	8.044e-69	258.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2VQ2F@28216|Betaproteobacteria,1KRY6@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Cytidylate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin
HKD3_k127_7756860_1	887898.HMPREF0551_0290	7.374e-306	947.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,1K30V@119060|Burkholderiaceae	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD3_k127_7756860_12	887898.HMPREF0551_0291	6.848e-46	167.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,1K7M8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD3_k127_7756860_14	1454004.AW11_01588	1.137e-15	81.0	COG5416@1|root,COG5416@2|Bacteria	2|Bacteria	FG	Lipopolysaccharide assembly protein A domain	lapA	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
HKD3_k127_7756860_8	882378.RBRH_01720	4.827e-118	391.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,1K171@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_7
HKD3_k127_7756860_9	543913.D521_1473	3.729e-109	387.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,1KQ96@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	pfkB family carbohydrate kinase	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272,ko:K21344	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD3_k127_7756860_5	391038.Bphy_0752	2.86e-145	484.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1K2B6@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
HKD3_k127_7756860_15	375286.mma_2664	9.122e-11	75.0	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,2VVT0@28216|Betaproteobacteria,4753T@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HKD3_k127_7756860_13	887898.HMPREF0551_0295	3.926e-35	145.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,1K3QR@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD3_k127_7789571_7	1504672.669787394	3.391e-24	102.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VI1V@28216|Betaproteobacteria,4ABKZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_7789571_3	864073.HFRIS_016200	1.019e-113	373.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,472G3@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	gstI	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_2
HKD3_k127_7789571_4	987059.RBXJA2T_02692	1.664e-109	361.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2VNEM@28216|Betaproteobacteria,1KJMA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_7789571_5	1265502.KB905936_gene2648	2.511e-47	183.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2VSCN@28216|Betaproteobacteria,4AECI@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1178
HKD3_k127_7789571_2	1198452.Jab_2c05970	2.043e-115	381.0	COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,472FU@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA	selU	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
HKD3_k127_7789571_1	1175306.GWL_16450	7.642e-167	545.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2VJCZ@28216|Betaproteobacteria,472JH@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	SurA N-terminal domain	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD3_k127_7789571_8	1121004.ATVC01000034_gene2252	1.046e-10	63.0	2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7789571_6	795666.MW7_1882	1.869e-40	151.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,1K8CW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD3_k127_7789571_0	85643.Tmz1t_2563	3.463e-255	792.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,2KUM5@206389|Rhodocyclales	206389|Rhodocyclales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD3_k127_7831151_4	305700.B447_04202	1.462e-52	199.0	COG1252@1|root,COG1252@2|Bacteria,1QUKT@1224|Proteobacteria,2WGU5@28216|Betaproteobacteria	28216|Betaproteobacteria	C	pyridine nucleotide-disulfide oxidoreductase family protein	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_7831151_2	1265502.KB905972_gene1336	1.512e-144	464.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,2VKSA@28216|Betaproteobacteria,4AANE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
HKD3_k127_7831151_0	522306.CAP2UW1_2826	7.348e-297	927.0	COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VH3T@28216|Betaproteobacteria,1KQAC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
HKD3_k127_7831151_3	1265502.KB905972_gene1334	4.452e-61	220.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria,4ADRH@80864|Comamonadaceae	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_7831151_6	314285.KT71_14569	2.15e-32	141.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria,1J6Q2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HKD3_k127_7831151_5	365046.Rta_03990	5.197e-40	166.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,2WFVG@28216|Betaproteobacteria,4AJTV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HKD3_k127_7831151_1	887898.HMPREF0551_0804	1.924e-237	755.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,1K063@119060|Burkholderiaceae	28216|Betaproteobacteria	T	domain protein	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	DUF2222,EAL,GGDEF,HAMP,MASE1,PAS,PAS_3,PAS_4,PAS_9
HKD3_k127_7831151_7	1217718.ALOU01000027_gene3690	2.324e-23	99.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K16W@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD3_k127_811802_0	987059.RBXJA2T_07573	8.085e-189	598.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,1KNFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD3_k127_811802_6	159087.Daro_0087	9.475e-83	280.0	COG1028@1|root,COG1028@2|Bacteria,1QKCK@1224|Proteobacteria,2VN0G@28216|Betaproteobacteria,2KXZG@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_811802_8	604331.AUHY01000001_gene1265	2.649e-62	219.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD3_k127_811802_4	1496688.ER33_14330	6.655e-89	306.0	COG2085@1|root,COG2085@2|Bacteria,1G18H@1117|Cyanobacteria	1117|Cyanobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD3_k127_811802_2	1185876.BN8_00658	2.569e-137	440.0	COG0693@1|root,COG0693@2|Bacteria,4NGII@976|Bacteroidetes,47K2N@768503|Cytophagia	976|Bacteroidetes	C	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD3_k127_811802_3	1235457.C404_17015	4.795e-120	393.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VQR6@28216|Betaproteobacteria,1K0MB@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_811802_9	941449.dsx2_3235	6.391e-49	193.0	COG4292@1|root,COG4292@2|Bacteria,1QWAK@1224|Proteobacteria,42ZNP@68525|delta/epsilon subdivisions,2WUUY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	K channel, inward rectifier, conserved region 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	IRK,LtrA
HKD3_k127_811802_5	1121861.KB899919_gene2708	4.427e-87	300.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JSUV@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_811802_1	1231391.AMZF01000020_gene1907	2.199e-160	518.0	COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,2VJN1@28216|Betaproteobacteria,3T2Y4@506|Alcaligenaceae	28216|Betaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD3_k127_811802_10	93220.LV28_13595	7.626e-40	159.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria,1K0F7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD3_k127_811802_7	1000565.METUNv1_00119	7.271e-80	273.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,2KVWJ@206389|Rhodocyclales	206389|Rhodocyclales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD3_k127_811802_13	1121127.JAFA01000020_gene506	1.868e-05	49.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2VZ7K@28216|Betaproteobacteria,1K6BR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD3_k127_811802_11	83406.HDN1F_19070	8.23e-35	143.0	2E9MD@1|root,333U1@2|Bacteria,1N912@1224|Proteobacteria,1SBKC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1282,Yip1
HKD3_k127_811802_12	1380358.JADJ01000001_gene1139	2.567e-18	87.0	COG1846@1|root,COG1846@2|Bacteria,1RJEE@1224|Proteobacteria,1SBSQ@1236|Gammaproteobacteria,1XPUC@135619|Oceanospirillales	135619|Oceanospirillales	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD3_k127_8321725_7	296591.Bpro_0763	3.516e-94	325.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACTU@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Transketolase central region	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD3_k127_8321725_3	296591.Bpro_0762	4.499e-153	520.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,4ADS6@80864|Comamonadaceae	28216|Betaproteobacteria	C	dehydrogenase, E1 component	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD3_k127_8321725_2	296591.Bpro_0761	3.083e-312	968.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,4ACHN@80864|Comamonadaceae	28216|Betaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_8321725_9	748280.NH8B_3197	1.77e-82	289.0	COG0477@1|root,COG2814@2|Bacteria,1PE5A@1224|Proteobacteria,2VHTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	emrB_1	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_8321725_5	420662.Mpe_A1207	6.883e-115	380.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2VH8U@28216|Betaproteobacteria,1KJJ5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD3_k127_8321725_6	1437824.BN940_04901	1.142e-97	334.0	COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2VMDP@28216|Betaproteobacteria,3T6RM@506|Alcaligenaceae	28216|Betaproteobacteria	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_4
HKD3_k127_8321725_4	338969.Rfer_0607	1.384e-127	413.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,2VJCQ@28216|Betaproteobacteria,4AB5Q@80864|Comamonadaceae	28216|Betaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD3_k127_8321725_10	269799.Gmet_2953	6.622e-68	241.0	COG4635@1|root,COG4635@2|Bacteria,1RAH2@1224|Proteobacteria,42WC7@68525|delta/epsilon subdivisions,2WSEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CH	Flavodoxin domain	hemG	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2953	Flavodoxin_5
HKD3_k127_8321725_11	748658.KB907312_gene1095	8.556e-38	146.0	COG2445@1|root,COG2445@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HKD3_k127_8321725_12	1255043.TVNIR_0026	1.062e-30	127.0	COG1669@1|root,COG1669@2|Bacteria,1NMHI@1224|Proteobacteria	1224|Proteobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD3_k127_8321725_14	713586.KB900536_gene1533	0.0005427	54.0	COG3577@1|root,COG3577@2|Bacteria,1MY8C@1224|Proteobacteria,1SBXM@1236|Gammaproteobacteria,1X0VU@135613|Chromatiales	135613|Chromatiales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
HKD3_k127_8321725_1	887898.HMPREF0551_0253	0.0	1120.0	COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJMS@28216|Betaproteobacteria,1K2EK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA	glcB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HKD3_k127_8321725_8	864051.BurJ1DRAFT_0830	1.748e-86	291.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2VI7A@28216|Betaproteobacteria,1KJI8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Haloacid dehalogenase-like hydrolase	dhlB	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HKD3_k127_8321725_0	1437882.AZRU01000028_gene769	0.0	1332.0	COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,1RQ9Q@1236|Gammaproteobacteria,1YF6W@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Biotin carboxylase C-terminal domain	pyc	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
HKD3_k127_8321725_13	378806.STAUR_4303	1.435e-23	119.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,42N6D@68525|delta/epsilon subdivisions,2X5IJ@28221|Deltaproteobacteria,2YWT3@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD3_k127_8465236_0	1121035.AUCH01000002_gene1415	0.0	1317.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KV6Z@206389|Rhodocyclales	206389|Rhodocyclales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_8465236_3	640081.Dsui_1556	7.649e-96	329.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,2KVQF@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD3_k127_8465236_1	1005048.CFU_4103	8.024e-153	493.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,4737T@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	PFAM Aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_8465236_6	349124.Hhal_1585	1.251e-70	241.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1WYRV@135613|Chromatiales	135613|Chromatiales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD3_k127_8465236_2	948106.AWZT01000044_gene5962	3.383e-139	468.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,1K1R1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	cfa2	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD3_k127_8465236_4	977880.RALTA_A1996	4.089e-89	302.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,1K213@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_8465236_5	760117.JN27_09320	2.17e-82	282.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,47260@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD3_k127_8477930_7	713587.THITH_10355	3.254e-57	200.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
HKD3_k127_8477930_1	713587.THITH_10360	6.428e-212	666.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_8477930_6	713587.THITH_10365	4.323e-59	220.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD3_k127_8477930_0	1255043.TVNIR_1954	1.307e-222	704.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD3_k127_8477930_8	1255043.TVNIR_1955	5.222e-57	216.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD3_k127_8477930_3	1255043.TVNIR_1956	1.1e-87	291.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD3_k127_8477930_11	713587.THITH_10385	1.733e-45	169.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD3_k127_8477930_4	887898.HMPREF0551_1730	5.102e-70	246.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,1K5KS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD3_k127_8477930_10	391735.Veis_0548	1.047e-47	176.0	COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,2VRG7@28216|Betaproteobacteria,4ADXZ@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM thioesterase superfamily protein	-	-	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
HKD3_k127_8477930_2	1121405.dsmv_3595	2.661e-143	470.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WJ1T@28221|Deltaproteobacteria,2MMK1@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.1.3.1,6.2.1.3	ko:K01897,ko:K22319	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	iAF987.Gmet_2229	AMP-binding,AMP-binding_C
HKD3_k127_8477930_5	357808.RoseRS_2516	3.146e-68	245.0	COG0620@1|root,COG0620@2|Bacteria,2G7J6@200795|Chloroflexi,377RE@32061|Chloroflexia	32061|Chloroflexia	H	PFAM Methionine synthase, vitamin-B12 independent	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HKD3_k127_8477930_9	1121033.AUCF01000030_gene174	1.641e-51	188.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U16N@28211|Alphaproteobacteria,2JVNK@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_8490667_6	381666.H16_B1609	2.914e-145	495.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1K2BP@119060|Burkholderiaceae	28216|Betaproteobacteria	MV	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_8490667_15	1348657.M622_07895	1.371e-64	231.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2VIQD@28216|Betaproteobacteria,2KWEW@206389|Rhodocyclales	206389|Rhodocyclales	V	COG1136 ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_8490667_16	420662.Mpe_A3241	1.322e-43	166.0	COG1226@1|root,31669@2|Bacteria,1RIW0@1224|Proteobacteria,2VWNP@28216|Betaproteobacteria	28216|Betaproteobacteria	P	COG1226 Kef-type K transport systems	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD3_k127_8490667_11	1217720.ALOX01000140_gene3573	2.047e-108	366.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2TV9J@28211|Alphaproteobacteria,2JQI6@204441|Rhodospirillales	204441|Rhodospirillales	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HKD3_k127_8490667_5	748280.NH8B_3618	4.249e-155	499.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KPG5@206351|Neisseriales	206351|Neisseriales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD3_k127_8490667_10	257310.BB4282	4.39e-121	398.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,3T1RP@506|Alcaligenaceae	28216|Betaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_8490667_1	887898.HMPREF0551_1142	1.191e-220	702.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2VHFM@28216|Betaproteobacteria,1K1NX@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD3_k127_8490667_4	887898.HMPREF0551_1141	1.257e-164	524.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2VIBF@28216|Betaproteobacteria,1K014@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	yejB	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HKD3_k127_8490667_3	795666.MW7_3426	1.229e-167	533.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2VHVN@28216|Betaproteobacteria,1K0DV@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	dppC2	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
HKD3_k127_8490667_2	1144342.PMI40_00774	4.966e-210	666.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,4724D@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA	-	-	ko:K02031,ko:K02032,ko:K13896	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
HKD3_k127_8490667_8	1500897.JQNA01000002_gene4645	9.749e-122	432.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HAMP,PAS,PAS_4,PAS_8,PAS_9,dCache_3
HKD3_k127_8490667_14	1095769.CAHF01000005_gene1498	8.004e-66	231.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_8490667_9	1120956.JHZK01000011_gene1269	1.919e-121	422.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,1JPNG@119043|Rhodobiaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS,PAS_7,PAS_9
HKD3_k127_8490667_0	257310.BB3420	4.122e-256	815.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,3T39S@506|Alcaligenaceae	28216|Betaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_8490667_13	269482.Bcep1808_2733	5.844e-89	297.0	COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2WEAK@28216|Betaproteobacteria,1K11E@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	qseB	-	-	ko:K02483,ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_8490667_12	887062.HGR_04363	1.411e-99	343.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,4A9VC@80864|Comamonadaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HKD3_k127_8490667_7	748247.AZKH_3439	7.188e-141	463.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KVHE@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_8521512_6	887898.HMPREF0551_0410	5.054e-200	630.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,1K30Z@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_8521512_16	123899.JPQP01000022_gene3289	8.379e-134	461.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VKC7@28216|Betaproteobacteria,3T757@506|Alcaligenaceae	28216|Betaproteobacteria	E	Threonine dehydratase	tdcB	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4,PALP
HKD3_k127_8521512_26	375286.mma_0338	8.351e-68	244.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2VR4K@28216|Betaproteobacteria,4742H@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Belongs to the glutathione peroxidase family	bsaA	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
HKD3_k127_8521512_34	292415.Tbd_0688	1.332e-30	140.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Putative_PNPOx,Pyrid_oxidase_2
HKD3_k127_8521512_0	243233.MCA2576	0.0	1264.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1XEFY@135618|Methylococcales	1236|Gammaproteobacteria	C	Formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_8,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_8521512_5	1502852.FG94_04244	9.555e-222	700.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,473CK@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_8521512_8	358220.C380_06040	3.568e-167	555.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,4AA4G@80864|Comamonadaceae	28216|Betaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HKD3_k127_8521512_7	887898.HMPREF0551_0407	4.706e-189	599.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,1K2CB@119060|Burkholderiaceae	28216|Betaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD3_k127_8521512_28	1337936.IJ00_27275	9.178e-54	194.0	COG3548@1|root,COG3548@2|Bacteria,1G8WP@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1211)	-	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD3_k127_8521512_2	75379.Tint_1788	0.0	1073.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,1KKDN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD3_k127_8521512_29	1005048.CFU_3848	1.539e-49	183.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,4746D@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD3_k127_8521512_14	1121035.AUCH01000002_gene1681	3.963e-149	481.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,2KUQE@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD3_k127_8521512_32	287.DR97_4010	4.515e-37	145.0	COG3631@1|root,COG3631@2|Bacteria,1MZ0P@1224|Proteobacteria,1S7Z4@1236|Gammaproteobacteria,1YG4C@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HKD3_k127_8521512_25	75379.Tint_0144	2.812e-76	267.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2VHJ3@28216|Betaproteobacteria,1KKV5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	subfamily IA, variant 3	cbbY	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD3_k127_8521512_19	266264.Rmet_1517	4.213e-109	359.0	COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,2VHJ3@28216|Betaproteobacteria,1K4K1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Mannitol_dh_C
HKD3_k127_8521512_9	1276756.AUEX01000021_gene3310	2.559e-166	531.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,2VHZD@28216|Betaproteobacteria,4ACB0@80864|Comamonadaceae	28216|Betaproteobacteria	C	Phosphoribulokinase / Uridine kinase family	cbbP	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HKD3_k127_8521512_13	543728.Vapar_3026	2.052e-149	482.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,4ACN6@80864|Comamonadaceae	28216|Betaproteobacteria	G	carbohydrate phosphatase activity	fbp1	-	3.1.3.11,3.1.3.37	ko:K01086	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase
HKD3_k127_8521512_11	395495.Lcho_3757	4.249e-159	506.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,1KKHM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_8521512_1	395495.Lcho_3765	0.0	1094.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJJW@28216|Betaproteobacteria,1KKYF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	von Willebrand factor (vWF) type A domain	cbbO2	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD3_k127_8521512_15	395495.Lcho_3766	9.383e-140	471.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2VHWI@28216|Betaproteobacteria,1KJRF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CbbQ/NirQ/NorQ C-terminal	cbbQ2	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
HKD3_k127_8521512_3	395495.Lcho_3767	1.139e-292	901.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,1KJRD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbM	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
HKD3_k127_8521512_12	1005048.CFU_3852	1.414e-149	481.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,473FA@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD3_k127_8521512_20	272560.BPSL2833	6.964e-100	336.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,1K12C@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD3_k127_8521512_10	1095769.CAHF01000013_gene3352	1.669e-164	550.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,47321@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD3_k127_8521512_23	1123367.C666_03970	2.197e-80	298.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2VHD7@28216|Betaproteobacteria,2KV6S@206389|Rhodocyclales	206389|Rhodocyclales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	Proteasome
HKD3_k127_8521512_24	1121004.ATVC01000029_gene82	2.198e-78	269.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VH3S@28216|Betaproteobacteria,2KQUQ@206351|Neisseriales	206351|Neisseriales	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD3_k127_8521512_22	1121004.ATVC01000029_gene81	1.661e-84	309.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KQUG@206351|Neisseriales	206351|Neisseriales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
HKD3_k127_8521512_4	1121004.ATVC01000029_gene80	2.139e-223	705.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,2KQRB@206351|Neisseriales	206351|Neisseriales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD3_k127_8521512_27	977880.RALTA_A2618	3.731e-66	239.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,1JZT8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD3_k127_8521512_35	887898.HMPREF0551_0391	3.787e-26	121.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
HKD3_k127_8521512_17	1286093.C266_01090	2.744e-116	392.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,1K3CP@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD3_k127_8521512_36	1388763.O165_007720	3.41e-25	114.0	COG2340@1|root,COG2340@2|Bacteria,1MZ84@1224|Proteobacteria,1SFYU@1236|Gammaproteobacteria,1YXJ3@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	PFAM SCP-like extracellular	-	-	-	-	-	-	-	-	-	-	-	-	CAP,PKD
HKD3_k127_8521512_33	1121035.AUCH01000001_gene2052	1.206e-33	143.0	COG3016@1|root,COG3016@2|Bacteria,1NXYQ@1224|Proteobacteria,2VTNU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg
HKD3_k127_8521512_37	1268622.AVS7_01927	2.316e-19	101.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,4AD9Q@80864|Comamonadaceae	28216|Betaproteobacteria	M	TIGRFAM TonB family protein	tonB	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD3_k127_8521512_21	375286.mma_2893	1.57e-90	309.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,47302@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Biopolymer transport	exbB2	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_8521512_30	864073.HFRIS_003278	1.441e-48	179.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,4780C@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Biopolymer transport	exbD	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_8521512_18	243365.CV_2696	7.543e-110	370.0	COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,2VNXI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD3_k127_8521512_31	420662.Mpe_A1428	2.718e-39	147.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,2VJRT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD3_k127_8533238_2	1005048.CFU_1599	4.656e-84	305.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,472YC@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD3_k127_8533238_1	420662.Mpe_A1410	2.49e-178	583.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,1KJ48@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD3_k127_8533238_0	123899.JPQP01000002_gene1080	2.595e-308	963.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,3T1EQ@506|Alcaligenaceae	28216|Betaproteobacteria	C	Catalyzes the transfer of electrons from NADH to ubiquinone	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD3_k127_8533238_3	1538295.JY96_04085	1.773e-76	257.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,1KJHB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_8549756_30	864051.BurJ1DRAFT_2300	3.938e-89	295.0	COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2VI5X@28216|Betaproteobacteria,1KMVB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD3_k127_8549756_14	76114.ebA6077	3.611e-153	494.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2VH6H@28216|Betaproteobacteria,2KV9P@206389|Rhodocyclales	206389|Rhodocyclales	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
HKD3_k127_8549756_34	123899.JPQP01000001_gene1734	3.19e-75	262.0	COG1024@1|root,COG1024@2|Bacteria,1MVA6@1224|Proteobacteria,2VK0W@28216|Betaproteobacteria,3T43J@506|Alcaligenaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_8549756_39	926560.KE387027_gene491	3.156e-59	209.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	dddQ	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,DMSP_lyase
HKD3_k127_8549756_24	526227.Mesil_0322	1.154e-111	379.0	COG1850@1|root,COG1850@2|Bacteria,1WJED@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Ribulose bisphosphate carboxylase large chain, catalytic domain	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large
HKD3_k127_8549756_41	640081.Dsui_2224	3.228e-40	154.0	COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2VW5P@28216|Betaproteobacteria,2KXN3@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
HKD3_k127_8549756_46	748658.KB907313_gene2080	5.715e-12	80.0	COG0589@1|root,COG0589@2|Bacteria,1N31F@1224|Proteobacteria,1S903@1236|Gammaproteobacteria,1WZ70@135613|Chromatiales	135613|Chromatiales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_8549756_2	396588.Tgr7_0259	3.229e-235	752.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD3_k127_8549756_11	1173024.KI912148_gene3523	5.73e-162	523.0	COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria	1117|Cyanobacteria	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD3_k127_8549756_36	1095769.CAHF01000022_gene38	8.081e-66	241.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VKAP@28216|Betaproteobacteria,474UX@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_8549756_26	382464.ABSI01000010_gene3722	1.521e-105	348.0	COG1028@1|root,COG1028@2|Bacteria	382464.ABSI01000010_gene3722|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8549756_6	1442599.JAAN01000019_gene2432	3.923e-200	639.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RPVQ@1236|Gammaproteobacteria,1X53T@135614|Xanthomonadales	135614|Xanthomonadales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
HKD3_k127_8549756_0	1472716.KBK24_0113805	3.161e-301	931.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,1K1SY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	abc transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HKD3_k127_8549756_22	266264.Rmet_2888	8.849e-115	379.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,2VP68@28216|Betaproteobacteria,1K1EY@119060|Burkholderiaceae	28216|Betaproteobacteria	C	luciferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD3_k127_8549756_32	388051.AUFE01000030_gene5088	9.231e-82	296.0	COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,2VJ3I@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HKD3_k127_8549756_25	1116369.KB890024_gene58	1.178e-107	364.0	COG0656@1|root,COG0656@2|Bacteria,1MUH2@1224|Proteobacteria,2TTC2@28211|Alphaproteobacteria,43HEX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Aldo/keto reductase family	yeaE	GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_8549756_44	296591.Bpro_1275	2.368e-24	107.0	COG4274@1|root,COG4274@2|Bacteria,1RKGA@1224|Proteobacteria	1224|Proteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD3_k127_8549756_19	365046.Rta_31960	3.041e-128	424.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VKAP@28216|Betaproteobacteria,4AB5B@80864|Comamonadaceae	28216|Betaproteobacteria	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_8549756_15	420662.Mpe_A3687	3.693e-150	484.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2VI0Z@28216|Betaproteobacteria,1KKQQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD3_k127_8549756_35	883078.HMPREF9695_03258	8.334e-75	276.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,3JT48@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD3_k127_8549756_29	543728.Vapar_5134	2.957e-98	350.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VI9J@28216|Betaproteobacteria,4AD1K@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_8549756_31	631454.N177_1097	3.31e-86	292.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,1JNBK@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_8549756_45	595537.Varpa_0253	3.769e-18	92.0	2CH9M@1|root,332CJ@2|Bacteria,1N7TS@1224|Proteobacteria,2VX3H@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8549756_40	1095769.CAHF01000013_gene3306	4.295e-57	207.0	COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,2VIYU@28216|Betaproteobacteria,475EJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
HKD3_k127_8549756_5	864051.BurJ1DRAFT_2085	1.65e-211	667.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHZI@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD3_k127_8549756_42	543728.Vapar_2222	1.609e-39	153.0	2E6D9@1|root,3310W@2|Bacteria,1N9Y9@1224|Proteobacteria,2VWRF@28216|Betaproteobacteria,4AHXJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD3_k127_8549756_12	864051.BurJ1DRAFT_2083	7.029e-160	509.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKQJ@28216|Betaproteobacteria,1KKBI@119065|unclassified Burkholderiales	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	MA20_15805	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_8549756_1	1038860.AXAP01000104_gene4208	3.086e-246	770.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JTDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	MA20_18835	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_8549756_27	1216976.AX27061_3923	8.184e-103	350.0	COG3181@1|root,COG3181@2|Bacteria,1NP0J@1224|Proteobacteria,2VHTG@28216|Betaproteobacteria,3T2SQ@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_8549756_33	296591.Bpro_4103	1.691e-79	301.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VM00@28216|Betaproteobacteria,4ABHF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Ankyrin repeats (3 copies)	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_4
HKD3_k127_8549756_16	1157708.KB907464_gene477	3.767e-145	474.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ACGH@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_8549756_13	543728.Vapar_4935	4.492e-154	496.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,4ACGH@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_8549756_7	1231392.OCGS_2830	1.604e-196	644.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_8549756_9	1231392.OCGS_2829	1.979e-173	557.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
HKD3_k127_8549756_8	342113.DM82_3220	1.326e-180	574.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH9Y@28216|Betaproteobacteria,1K0HZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_8549756_23	1121127.JAFA01000047_gene34	7.287e-112	369.0	COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2VHNF@28216|Betaproteobacteria,1K68P@119060|Burkholderiaceae	28216|Betaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD3_k127_8549756_17	1217718.ALOU01000005_gene1445	5.796e-132	430.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VJQ2@28216|Betaproteobacteria,1KGKB@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD3_k127_8549756_21	864051.BurJ1DRAFT_1799	6.489e-117	402.0	COG0604@1|root,COG0604@2|Bacteria,1QUNT@1224|Proteobacteria,2VM3W@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Protein of unknown function (DUF2855)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2855
HKD3_k127_8549756_20	1297863.APJF01000013_gene3998	2.276e-127	411.0	COG2043@1|root,COG2043@2|Bacteria,1NR18@1224|Proteobacteria,2TVGP@28211|Alphaproteobacteria,3JU0D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised ArCR, COG2043	MA20_36865	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD3_k127_8549756_10	1007105.PT7_1206	2.443e-171	557.0	COG0477@1|root,COG2814@2|Bacteria,1MX2P@1224|Proteobacteria,2VIIJ@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_8549756_43	395019.Bmul_5791	4.638e-31	131.0	COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,2VTNW@28216|Betaproteobacteria,1KGYY@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Uncharacterised protein family (UPF0149)	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
HKD3_k127_8549756_3	292415.Tbd_1306	2.491e-234	746.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,1KSQ2@119069|Hydrogenophilales	28216|Betaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_8549756_37	652103.Rpdx1_0255	3.075e-65	254.0	COG3631@1|root,COG3631@2|Bacteria,1P5A2@1224|Proteobacteria,2TV5B@28211|Alphaproteobacteria,3JR2U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_8549756_18	189753.AXAS01000015_gene1085	1.369e-131	424.0	COG1024@1|root,COG1024@2|Bacteria,1MXZ2@1224|Proteobacteria,2TRQ8@28211|Alphaproteobacteria,3JVYF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	enoyl-CoA hydratase	MA20_25215	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_8549756_28	196367.JNFG01000209_gene239	1.043e-102	340.0	COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,2VK5Z@28216|Betaproteobacteria,1K0NP@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_8549756_38	525904.Tter_1979	2.621e-61	226.0	COG2084@1|root,COG2084@2|Bacteria,2NP96@2323|unclassified Bacteria	2|Bacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_29235	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_8549756_4	596154.Alide2_0526	5.261e-214	677.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,4A9MZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the GMC oxidoreductase family	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_8549756_47	580332.Slit_1397	2.141e-06	53.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,44VXR@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD3_k127_8553012_3	1502852.FG94_01888	4.184e-180	578.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,472HN@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD3_k127_8553012_9	395495.Lcho_4258	8.032e-36	141.0	COG5611@1|root,COG5611@2|Bacteria,1N9JM@1224|Proteobacteria,2VWRE@28216|Betaproteobacteria,1KMSU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD3_k127_8553012_2	1411123.JQNH01000001_gene3587	8.914e-201	634.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD3_k127_8553012_4	1268622.AVS7_02547	3.223e-164	523.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD3_k127_8553012_0	1123504.JQKD01000013_gene1006	0.0	1054.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,4ABBZ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HKD3_k127_8553012_7	367299.JOEE01000002_gene2268	3.525e-87	326.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4FF5X@85021|Intrasporangiaceae	201174|Actinobacteria	C	CoA-transferase family III	Amacr	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD3_k127_8553012_6	1216976.AX27061_3238	3.066e-110	371.0	COG0697@1|root,COG0697@2|Bacteria,1MW7P@1224|Proteobacteria,2VHDI@28216|Betaproteobacteria,3T6XY@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	ytfF	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_8553012_10	1121035.AUCH01000013_gene3163	7.683e-25	115.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD3_k127_8553012_8	1265502.KB905938_gene2512	3.118e-81	286.0	COG0477@1|root,COG2814@2|Bacteria,1QUY6@1224|Proteobacteria,2VNN5@28216|Betaproteobacteria,4AAMP@80864|Comamonadaceae	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_8553012_11	883126.HMPREF9710_05211	4.594e-22	113.0	2EBNJ@1|root,335NT@2|Bacteria,1N847@1224|Proteobacteria,2VW9H@28216|Betaproteobacteria,474HJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8553012_12	420662.Mpe_A0332	8.441e-20	100.0	2E54A@1|root,32ZX9@2|Bacteria,1N8HJ@1224|Proteobacteria,2VVW9@28216|Betaproteobacteria,1KMNY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
HKD3_k127_8553012_1	1265502.KB905938_gene2419	5.772e-216	682.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,4ABQY@80864|Comamonadaceae	28216|Betaproteobacteria	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_8553012_5	305700.B447_12222	1.038e-148	481.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,2KVG7@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD3_k127_8553012_14	713586.KB900536_gene465	1.977e-12	67.0	COG2175@1|root,COG2175@2|Bacteria,1R5KS@1224|Proteobacteria,1RZQ2@1236|Gammaproteobacteria,1WXSM@135613|Chromatiales	135613|Chromatiales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD3_k127_8573928_4	1205680.CAKO01000029_gene5194	4.183e-39	151.0	COG0697@1|root,COG0697@2|Bacteria,1R6CU@1224|Proteobacteria,2UCTR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_8573928_2	123899.JPQP01000006_gene705	1.003e-88	297.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2VHAM@28216|Betaproteobacteria,3T1WX@506|Alcaligenaceae	28216|Betaproteobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD3_k127_8573928_3	1122951.ATUE01000006_gene1049	5.513e-82	289.0	COG1893@1|root,COG1893@2|Bacteria,1N0M5@1224|Proteobacteria,1RNZY@1236|Gammaproteobacteria,3NM1M@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_8573928_1	1205680.CAKO01000002_gene2921	1.235e-99	329.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2JS04@204441|Rhodospirillales	204441|Rhodospirillales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD3_k127_8573928_5	1385935.N836_10705	2.533e-30	136.0	2ETWY@1|root,32VZU@2|Bacteria,1G9Y9@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8573928_0	1205680.CAKO01000005_gene3546	1.836e-156	497.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TTGM@28211|Alphaproteobacteria,2JPI4@204441|Rhodospirillales	204441|Rhodospirillales	E	Peptidase family M20/M25/M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_8583685_2	420662.Mpe_A1439	1.382e-120	421.0	COG3596@1|root,COG3596@2|Bacteria,1R01T@1224|Proteobacteria,2WHSI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF3482)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3482,MMR_HSR1
HKD3_k127_8583685_5	522306.CAP2UW1_0180	4.889e-37	162.0	28KUM@1|root,2ZABC@2|Bacteria,1R683@1224|Proteobacteria,2VPU1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868,DUF3482
HKD3_k127_8583685_4	448385.sce3014	6.663e-50	193.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,42WKH@68525|delta/epsilon subdivisions,2WSGE@28221|Deltaproteobacteria,2YVQV@29|Myxococcales	28221|Deltaproteobacteria	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD3_k127_8583685_6	502025.Hoch_5610	2.077e-35	157.0	COG2267@1|root,COG2267@2|Bacteria,1QUFU@1224|Proteobacteria,43BQ1@68525|delta/epsilon subdivisions,2X718@28221|Deltaproteobacteria,2Z3MK@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	menH	-	4.2.99.20	ko:K08680	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08166	RC02148,RC02475	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_6
HKD3_k127_8583685_1	1254432.SCE1572_18295	4.323e-141	478.0	COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,42PNC@68525|delta/epsilon subdivisions,2WKSZ@28221|Deltaproteobacteria,2YUJF@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
HKD3_k127_8583685_3	502025.Hoch_5716	7.738e-84	296.0	COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,42S21@68525|delta/epsilon subdivisions,2WNRS@28221|Deltaproteobacteria,2YV7S@29|Myxococcales	28221|Deltaproteobacteria	HQ	chorismate binding enzyme	menF	-	5.4.4.2	ko:K01851,ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
HKD3_k127_8583685_0	887062.HGR_09289	2.601e-216	681.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,4ACBD@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	rosB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HKD3_k127_8588547_12	876044.IMCC3088_756	7.545e-10	60.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1J4DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
HKD3_k127_8588547_1	1265502.KB905949_gene973	4.269e-170	539.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,4AC6F@80864|Comamonadaceae	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD3_k127_8588547_5	887898.HMPREF0551_0139	1.871e-62	220.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2VQ3U@28216|Betaproteobacteria,1K0TT@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD3_k127_8588547_4	1095769.CAHF01000001_gene3525	1.235e-78	266.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,473AX@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD3_k127_8588547_0	93220.LV28_18490	6.162e-176	556.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD3_k127_8588547_11	767434.Fraau_2874	9.109e-28	129.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1X6W5@135614|Xanthomonadales	135614|Xanthomonadales	S	Acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD3_k127_8588547_3	667632.KB890187_gene3139	1.768e-88	301.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,1K1BT@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD3_k127_8588547_9	887898.HMPREF0551_0133	1.134e-33	135.0	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria,1K862@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Pfam Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD3_k127_8588547_10	887898.HMPREF0551_0132	2.049e-29	132.0	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,2VKUS@28216|Betaproteobacteria,1K227@119060|Burkholderiaceae	28216|Betaproteobacteria	M	TIGRFAM protein TolA	tolA	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HKD3_k127_8588547_2	887898.HMPREF0551_0131	3.198e-168	543.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,1K0Y6@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD3_k127_8588547_6	556269.ACDQ01000011_gene160	7.059e-61	215.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,4744Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD3_k127_8588547_8	375286.mma_2469	3.051e-54	210.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,4730Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
HKD3_k127_8588547_7	381666.H16_A2825	2.532e-55	204.0	COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,1K5NZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD3_k127_8588627_8	267608.RSc2378	2.959e-26	115.0	2DBXD@1|root,2ZBP6@2|Bacteria,1RB44@1224|Proteobacteria,2VQT3@28216|Betaproteobacteria,1K3GG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
HKD3_k127_8588627_0	1265502.KB905935_gene3084	3.007e-168	546.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4AB8M@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD3_k127_8588627_3	1000565.METUNv1_04051	4.132e-112	383.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD3_k127_8588627_5	1304883.KI912532_gene2260	4.471e-65	230.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD3_k127_8588627_1	1265502.KB905935_gene3088	5.808e-167	545.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,4AAFY@80864|Comamonadaceae	28216|Betaproteobacteria	H	MoeA domain protein domain I and II	moeA2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD3_k127_8588627_6	1192124.LIG30_3203	6.51e-61	228.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,2VR2C@28216|Betaproteobacteria,1K794@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	rraA	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
HKD3_k127_8588627_7	582744.Msip34_1186	4.783e-57	216.0	COG1538@1|root,COG1538@2|Bacteria,1R744@1224|Proteobacteria,2VJW4@28216|Betaproteobacteria,2KKZE@206350|Nitrosomonadales	206350|Nitrosomonadales	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
HKD3_k127_8588627_4	266264.Rmet_3837	9.891e-70	267.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,1K31F@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	CusF_Ec,HlyD_D23
HKD3_k127_8588627_2	977880.RALTA_B0380	2.218e-127	414.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VKKR@28216|Betaproteobacteria,1KGCX@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
HKD3_k127_8608392_4	582744.Msip34_0169	2.777e-167	556.0	COG1629@1|root,COG4771@2|Bacteria,1QTS8@1224|Proteobacteria,2WGGE@28216|Betaproteobacteria,2KM9M@206350|Nitrosomonadales	206350|Nitrosomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD3_k127_8608392_7	1095769.CAHF01000018_gene815	9.551e-100	338.0	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,2VM18@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Ammonia monooxygenase	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
HKD3_k127_8608392_13	1126627.BAWE01000005_gene5495	3.818e-36	143.0	COG2050@1|root,COG2050@2|Bacteria,1MYM3@1224|Proteobacteria,2U5K2@28211|Alphaproteobacteria,3JR03@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	MA20_08885	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD3_k127_8608392_5	1217718.ALOU01000093_gene1767	1.763e-102	344.0	COG1752@1|root,COG1752@2|Bacteria,1REEJ@1224|Proteobacteria,2VRMU@28216|Betaproteobacteria,1K0ZP@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD3_k127_8608392_8	994479.GL877878_gene1653	5.563e-68	247.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD3_k127_8608392_12	1366050.N234_20735	6.585e-49	188.0	COG2258@1|root,COG2258@2|Bacteria,1RAPM@1224|Proteobacteria,2VQFZ@28216|Betaproteobacteria,1K8UB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD3_k127_8608392_10	402881.Plav_1560	5.353e-61	226.0	COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria,2U3MG@28211|Alphaproteobacteria	1224|Proteobacteria	E	Protein of unknown function (DUF2817)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2817
HKD3_k127_8608392_11	426117.M446_1050	1.631e-56	214.0	COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria,2VB4S@28211|Alphaproteobacteria,1JT96@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	2-keto-4-pentenoate hydratase	-	-	4.1.1.77	ko:K01617	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R02602,R05374	RC00751,RC02672	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD3_k127_8608392_9	1121033.AUCF01000015_gene1496	1.589e-62	222.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2U1PX@28211|Alphaproteobacteria,2JRDE@204441|Rhodospirillales	204441|Rhodospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_8608392_0	1095769.CAHF01000018_gene820	0.0	1040.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,472VX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD3_k127_8608392_6	998088.B565_1614	4.925e-101	340.0	COG0583@1|root,COG0583@2|Bacteria,1MU3N@1224|Proteobacteria,1RSDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	cynR_1	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_8608392_1	502025.Hoch_2997	7.878e-281	885.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42NEV@68525|delta/epsilon subdivisions,2WJD0@28221|Deltaproteobacteria,2YTU2@29|Myxococcales	28221|Deltaproteobacteria	C	Molydopterin dinucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_8608392_14	1449976.KALB_7362	5.274e-25	112.0	COG1309@1|root,COG1309@2|Bacteria,2IK52@201174|Actinobacteria,4E3K8@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_8608392_2	1048339.KB913029_gene4089	6.725e-280	900.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GM4U@201174|Actinobacteria,4EUPX@85013|Frankiales	201174|Actinobacteria	KT	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
HKD3_k127_8608392_15	338969.Rfer_2228	1.357e-09	64.0	COG2346@1|root,COG2346@2|Bacteria,1PTR2@1224|Proteobacteria,2VVD1@28216|Betaproteobacteria,4AI2B@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD3_k127_8608392_3	1458275.AZ34_11740	7.116e-205	646.0	COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,2WFDT@28216|Betaproteobacteria,4AJSA@80864|Comamonadaceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD3_k127_8625849_9	396588.Tgr7_0116	5.259e-77	258.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales	135613|Chromatiales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HKD3_k127_8625849_12	887898.HMPREF0551_1482	1.471e-57	212.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,1K1HI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_8625849_13	999541.bgla_1g29770	7.838e-53	197.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,1K6ZB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD3_k127_8625849_15	887898.HMPREF0551_1484	4.799e-50	183.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,1K1UB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD3_k127_8625849_11	795666.MW7_0924	6.896e-59	212.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,1JZPF@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD3_k127_8625849_0	1218076.BAYB01000012_gene2579	4.441e-227	720.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,1K12W@119060|Burkholderiaceae	28216|Betaproteobacteria	J	ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD3_k127_8625849_4	1458275.AZ34_09505	9e-112	394.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VKTQ@28216|Betaproteobacteria,4ABGJ@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_8625849_2	762966.HMPREF9439_00294	8.483e-165	542.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4PQQA@995019|Sutterellaceae	28216|Betaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K02021,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_8625849_6	795666.MW7_2113	2.53e-89	312.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,1K5FE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 9	rfaQ	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD3_k127_8625849_5	243231.GSU2254	4.356e-95	323.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,42M23@68525|delta/epsilon subdivisions,2WNU9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_8625849_7	686340.Metal_0859	1.833e-80	289.0	COG1216@1|root,COG1216@2|Bacteria,1QV95@1224|Proteobacteria,1T2AK@1236|Gammaproteobacteria,1XDMA@135618|Methylococcales	135618|Methylococcales	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HKD3_k127_8625849_14	697282.Mettu_0645	1.072e-51	206.0	COG3307@1|root,COG3307@2|Bacteria,1R495@1224|Proteobacteria,1T8HU@1236|Gammaproteobacteria,1XFR9@135618|Methylococcales	135618|Methylococcales	M	PFAM O-Antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD3_k127_8625849_10	697282.Mettu_1858	1.6e-69	244.0	COG3306@1|root,COG3306@2|Bacteria,1NERS@1224|Proteobacteria,1SG2P@1236|Gammaproteobacteria,1XG4D@135618|Methylococcales	135618|Methylococcales	M	PFAM Glycosyl transferase, family 25	-	-	-	ko:K07270	-	-	-	-	ko00000	-	GT25	-	Glyco_transf_25
HKD3_k127_8625849_8	614083.AWQR01000014_gene2481	2.24e-80	289.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2VIMU@28216|Betaproteobacteria,4AB9C@80864|Comamonadaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD3_k127_8625849_3	76114.ebA1639	7.062e-121	396.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,2KUD6@206389|Rhodocyclales	206389|Rhodocyclales	M	epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD3_k127_8625849_1	887898.HMPREF0551_1491	1.535e-169	544.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD3_k127_8641546_11	159450.NH14_24330	1.799e-18	85.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1K2BX@119060|Burkholderiaceae	28216|Betaproteobacteria	M	heptosyltransferase II	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD3_k127_8641546_2	1159870.KB907784_gene440	7.82e-122	399.0	COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,3T1CT@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,ACT_6,Formyl_trans_N
HKD3_k127_8641546_10	1265502.KB905955_gene451	3.569e-35	141.0	COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,4AE1B@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD3_k127_8641546_1	1502852.FG94_03034	3.045e-122	400.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,473G7@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
HKD3_k127_8641546_8	477184.KYC_03224	1.924e-44	169.0	2CDFS@1|root,32RXQ@2|Bacteria,1N09V@1224|Proteobacteria,2VUR5@28216|Betaproteobacteria,3T474@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2946)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2944
HKD3_k127_8641546_5	1095769.CAHF01000011_gene2117	1.078e-75	282.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153,4.2.1.56	ko:K09709,ko:K18291	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R02491,R09282	RC00730,RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
HKD3_k127_8641546_4	887898.HMPREF0551_1692	6.493e-113	392.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,1K0VI@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Peptidase M48	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
HKD3_k127_8641546_7	93220.LV28_07730	4.038e-68	260.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,1K4PP@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD3_k127_8641546_9	1144312.PMI09_04874	2.334e-43	168.0	COG2044@1|root,COG2044@2|Bacteria,1RGAZ@1224|Proteobacteria,2UBFX@28211|Alphaproteobacteria,4BEWP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD3_k127_8641546_0	338969.Rfer_3515	1.381e-160	509.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2VTNF@28216|Betaproteobacteria,4AF7C@80864|Comamonadaceae	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
HKD3_k127_8641546_6	864051.BurJ1DRAFT_0599	2.879e-69	238.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2VRD4@28216|Betaproteobacteria,1KNIW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA3	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_8641546_3	296591.Bpro_1676	7.312e-119	389.0	COG0500@1|root,COG2226@2|Bacteria,1R79J@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_8667198_9	582744.Msip34_1510	7.957e-74	256.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,2KM7V@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
HKD3_k127_8667198_4	420662.Mpe_A2481	6.774e-112	364.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,1KK0G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1,3.1.11.6	ko:K03601,ko:K04564	ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD3_k127_8667198_1	1144319.PMI16_01014	7.113e-125	415.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,47388@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD3_k127_8667198_7	887898.HMPREF0551_1221	1.193e-82	284.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,1K3AM@119060|Burkholderiaceae	28216|Betaproteobacteria	U	MotA TolQ ExbB proton channel	exbB2	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_8667198_12	1120999.JONM01000023_gene3186	6.669e-38	153.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria,2KRJ1@206351|Neisseriales	206351|Neisseriales	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_8667198_8	887898.HMPREF0551_1223	4.41e-81	282.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,1K28I@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD3_k127_8667198_13	1158292.JPOE01000002_gene2781	3.472e-21	93.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,1KMJ3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0434 family	ycaR	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD3_k127_8667198_6	388051.AUFE01000026_gene5158	2.595e-96	324.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,1K2A1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD3_k127_8667198_2	748247.AZKH_3243	5.586e-115	382.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,2KUU9@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD3_k127_8667198_0	1157708.KB907450_gene6171	0.0	1043.0	COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,4AA75@80864|Comamonadaceae	28216|Betaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
HKD3_k127_8667198_5	3988.XP_002534847.1	1.611e-109	361.0	KOG1199@1|root,KOG1199@2759|Eukaryota	2759|Eukaryota	S	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	-	-	1.1.1.178,1.1.1.35	ko:K08683	ko00280,ko01100,ko01110,ko01130,ko05010,map00280,map01100,map01110,map01130,map05010	-	R04203	RC00525	ko00000,ko00001,ko01000,ko03029,ko04147	-	-	-	adh_short
HKD3_k127_8667198_11	614083.AWQR01000010_gene1634	3.538e-55	210.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,2VPBU@28216|Betaproteobacteria,4ACPA@80864|Comamonadaceae	28216|Betaproteobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
HKD3_k127_8667198_10	1134912.AJTV01000008_gene1868	6.678e-71	246.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,2U44Q@28211|Alphaproteobacteria,36ZEX@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_8667198_3	887898.HMPREF0551_1227	1.111e-114	382.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2VJN4@28216|Betaproteobacteria,1K1B5@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the amidase family	gatA_3	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_8671341_12	1265502.KB905969_gene1232	1.848e-07	56.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2VHK0@28216|Betaproteobacteria,4A9P3@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HKD3_k127_8671341_5	795666.MW7_2494	6.264e-118	387.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,1K2AG@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD3_k127_8671341_0	264198.Reut_A0639	5.127e-296	924.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,1JZV8@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD3_k127_8671341_10	1005048.CFU_0897	1.589e-14	76.0	2EKIA@1|root,33E87@2|Bacteria,1NNCS@1224|Proteobacteria,2VYAC@28216|Betaproteobacteria,474ZJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8671341_9	62928.azo3500	4.762e-35	138.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KZ1V@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD3_k127_8671341_3	1175306.GWL_43570	1.05e-128	418.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,473DS@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_8671341_2	859657.RPSI07_1035	2.404e-149	482.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,1K3R4@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_8671341_4	864051.BurJ1DRAFT_1702	2.228e-123	418.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,1KK0Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_8671341_6	1235457.C404_16875	5.356e-109	357.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,1K1Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	E	abc transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_8671341_1	864073.HFRIS_007991	3.317e-160	515.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,47360@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Oxidoreductase FAD-binding domain	ascD	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_8671341_8	1198452.Jab_1c16640	8.382e-87	312.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,473J1@75682|Oxalobacteraceae	28216|Betaproteobacteria	GM	RmlD substrate binding domain	yeeZ	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N
HKD3_k127_8671341_7	314254.OA2633_12935	1.383e-101	344.0	COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,43WHY@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HKD3_k127_8671341_11	864051.BurJ1DRAFT_1843	1.123e-08	64.0	2EF6U@1|root,338ZV@2|Bacteria,1NFKF@1224|Proteobacteria,2VY9J@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8720432_4	1123248.KB893370_gene5116	1.223e-69	245.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_8720432_2	279714.FuraDRAFT_1484	4.761e-83	289.0	COG0625@1|root,COG0625@2|Bacteria,1RK1K@1224|Proteobacteria,2WEV9@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N_3
HKD3_k127_8720432_5	472759.Nhal_0303	1.145e-57	216.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_8720432_7	472759.Nhal_0303	0.0002177	44.0	COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_8720432_1	338969.Rfer_2416	1.92e-149	481.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VSDG@28216|Betaproteobacteria,4AFT8@80864|Comamonadaceae	28216|Betaproteobacteria	I	Steryl acetyl hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD3_k127_8720432_0	1268622.AVS7_02087	6.128e-178	570.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,4AA08@80864|Comamonadaceae	28216|Betaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_8720432_3	883126.HMPREF9710_00309	2.241e-75	258.0	COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,2VKE3@28216|Betaproteobacteria,475IF@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_8720432_6	75379.Tint_2602	2.687e-08	58.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VIJU@28216|Betaproteobacteria,1KJ7P@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD3_k127_8725752_13	68170.KL590510_gene7215	2.055e-69	247.0	COG3647@1|root,COG3647@2|Bacteria,2IATE@201174|Actinobacteria,4E3YF@85010|Pseudonocardiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2238)	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
HKD3_k127_8725752_18	114615.BRADO2596	6.809e-33	135.0	COG1846@1|root,COG1846@2|Bacteria,1RCY7@1224|Proteobacteria,2UAR3@28211|Alphaproteobacteria,3JV5I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD3_k127_8725752_10	264198.Reut_C5929	3.333e-105	369.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI9Y@28216|Betaproteobacteria,1K1EI@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_8725752_7	3988.XP_002536891.1	8.319e-123	400.0	COG0329@1|root,2QQ8M@2759|Eukaryota	2759|Eukaryota	EM	4-hydroxy-tetrahydrodipicolinate synthase	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS,Saccharop_dh_N
HKD3_k127_8725752_15	1242864.D187_010264	3.068e-51	201.0	COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,42UCW@68525|delta/epsilon subdivisions,2WQWQ@28221|Deltaproteobacteria,2YV6G@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD3_k127_8725752_17	1122212.AULO01000012_gene1037	6.703e-35	138.0	COG3232@1|root,COG3232@2|Bacteria,1RB8A@1224|Proteobacteria,1S3SG@1236|Gammaproteobacteria,1XJWW@135619|Oceanospirillales	135619|Oceanospirillales	E	5-carboxymethyl-2-hydroxymuconate isomerase	-	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	CHMI
HKD3_k127_8725752_1	392499.Swit_4305	2.12e-223	712.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales	204457|Sphingomonadales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.60,1.2.1.8	ko:K00130,ko:K00151	ko00260,ko00350,ko01100,ko01120,ko01220,map00260,map00350,map01100,map01120,map01220	M00533,M00555	R02565,R02566,R04418	RC00080,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_8725752_3	1235457.C404_11170	6.59e-147	470.0	COG3384@1|root,COG3384@2|Bacteria,1MWNC@1224|Proteobacteria,2VK29@28216|Betaproteobacteria,1K1CE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	3,4-dihydroxyphenylacetate 2,3-dioxygenase	hpaD	-	1.13.11.15	ko:K00455	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R03303	RC00643	ko00000,ko00001,ko00002,ko01000	-	-	-	LigB
HKD3_k127_8725752_6	402626.Rpic_3557	2.423e-124	402.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VM54@28216|Betaproteobacteria,1K54E@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Class II aldolase adducin family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD3_k127_8725752_8	1159870.KB907784_gene3298	6.933e-119	394.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,3T72N@506|Alcaligenaceae	28216|Betaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	panE2	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_8725752_11	339670.Bamb_2605	2.48e-78	267.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,1K2NU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ebsC	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD3_k127_8725752_12	859657.RPSI07_0920	4.513e-77	263.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,1K08V@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD3_k127_8725752_9	1380394.JADL01000009_gene3266	6.716e-116	383.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,2TRRU@28211|Alphaproteobacteria,2JQ4F@204441|Rhodospirillales	204441|Rhodospirillales	GK	ROK family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	ROK
HKD3_k127_8725752_20	1041142.ATTP01000031_gene3917	1.312e-19	97.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HKD3_k127_8725752_16	1123247.AUIJ01000015_gene1378	7.921e-46	181.0	2B1WH@1|root,30C4Q@2|Bacteria,1R3E9@1224|Proteobacteria,2U7UN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD3_k127_8725752_4	1005048.CFU_1035	4.986e-136	441.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,473WF@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD3_k127_8725752_5	292.DM42_1960	7.171e-131	426.0	COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2VJKY@28216|Betaproteobacteria,1K3YV@119060|Burkholderiaceae	28216|Betaproteobacteria	O	PFAM AAA ATPase central domain protein	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA
HKD3_k127_8725752_19	742821.HMPREF9464_01470	2.777e-32	126.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,2VTZ4@28216|Betaproteobacteria,4PRA8@995019|Sutterellaceae	28216|Betaproteobacteria	J	Ribosomal protein S21	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD3_k127_8725752_14	391038.Bphy_3943	3.531e-54	201.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,1K70P@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD3_k127_8725752_2	887898.HMPREF0551_1525	1.105e-177	580.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,1K36X@119060|Burkholderiaceae	28216|Betaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD3_k127_8725752_0	1158292.JPOE01000002_gene2787	4.241e-237	764.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,1KJFB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD3_k127_8765218_7	1123368.AUIS01000008_gene2247	8.894e-84	279.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,2NC8X@225057|Acidithiobacillales	225057|Acidithiobacillales	O	hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD3_k127_8765218_0	640081.Dsui_1155	2.266e-215	683.0	COG0223@1|root,COG1024@1|root,COG0223@2|Bacteria,COG1024@2|Bacteria,1MWYJ@1224|Proteobacteria,2VK38@28216|Betaproteobacteria,2KVS4@206389|Rhodocyclales	206389|Rhodocyclales	IJ	Formyl transferase, C-terminal domain	-	-	-	ko:K19640	-	-	-	-	ko00000,ko02022	-	-	-	ECH_1,Formyl_trans_C,Formyl_trans_N
HKD3_k127_8765218_8	420662.Mpe_A1386	1.302e-05	52.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,1KM92@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_8765218_4	290397.Adeh_1659	5.618e-149	485.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD3_k127_8765218_3	880073.Calab_1598	9.658e-153	511.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria	2|Bacteria	P	Prokaryotic cytochrome b561	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HKD3_k127_8765218_5	365044.Pnap_2699	1.262e-108	368.0	COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,2VMFZ@28216|Betaproteobacteria,4ACYZ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8765218_6	76114.ebA3861	9.922e-101	372.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,2VIZ8@28216|Betaproteobacteria,2KVMB@206389|Rhodocyclales	206389|Rhodocyclales	S	Beta-lactamase	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD3_k127_8765218_2	1095769.CAHF01000021_gene918	7.193e-161	517.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2VH5W@28216|Betaproteobacteria,476JW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HKD3_k127_8765218_1	1265502.KB905933_gene2082	7.045e-184	583.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2VH5W@28216|Betaproteobacteria,4ACEQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM Basic membrane lipoprotein	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HKD3_k127_8768877_10	648757.Rvan_0038	1.766e-72	267.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD3_k127_8768877_4	1232410.KI421421_gene3270	3.947e-179	583.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD3_k127_8768877_8	85643.Tmz1t_2952	7.461e-93	315.0	COG1024@1|root,COG1024@2|Bacteria,1R7WW@1224|Proteobacteria,2VUI3@28216|Betaproteobacteria,2KWVM@206389|Rhodocyclales	206389|Rhodocyclales	I	Enoyl-CoA hydratase/isomerase	dch	-	4.2.1.100	ko:K07537	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05597	RC03168	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_8768877_3	648757.Rvan_0035	5.153e-184	605.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_8768877_5	1187851.A33M_3193	9.512e-157	502.0	COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	yphC	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD3_k127_8768877_1	85643.Tmz1t_2955	9.585e-213	676.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD3_k127_8768877_6	85643.Tmz1t_2956	2.157e-118	409.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_8768877_12	1244869.H261_00720	1.96e-35	145.0	COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria,2JTDY@204441|Rhodospirillales	204441|Rhodospirillales	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD3_k127_8768877_11	1244869.H261_12176	2.264e-55	198.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2U9A9@28211|Alphaproteobacteria,2JSX2@204441|Rhodospirillales	204441|Rhodospirillales	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_8768877_0	522306.CAP2UW1_1324	2.951e-239	755.0	COG0543@1|root,COG1018@1|root,COG1290@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,COG1290@2|Bacteria,1MV72@1224|Proteobacteria,2VI6M@28216|Betaproteobacteria,1KR75@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_8768877_7	1266925.JHVX01000001_gene2483	3.147e-117	395.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD3_k127_8768877_13	1123360.thalar_02883	8.255e-13	72.0	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8768877_9	1437824.BN940_02346	5.528e-91	301.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome c oxidase (Subunit II)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HKD3_k127_8768877_2	1437824.BN940_02351	6.209e-197	619.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome C oxidase subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD3_k127_8804222_5	1144319.PMI16_04564	6.068e-54	192.0	COG0824@1|root,COG0824@2|Bacteria,1RG6B@1224|Proteobacteria,2VTAU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	-Thioesterase	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
HKD3_k127_8804222_1	1110502.TMO_3126	5.422e-161	524.0	COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2TRRC@28211|Alphaproteobacteria,2JZIC@204441|Rhodospirillales	204441|Rhodospirillales	CH	FAD binding domain	-	-	1.14.13.218	ko:K20940	ko00405,ko01130,map00405,map01130	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD3_k127_8804222_3	396588.Tgr7_1472	1.31e-111	368.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,1T1T1@1236|Gammaproteobacteria,1X2QZ@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_8804222_4	365046.Rta_23870	3.228e-95	326.0	COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,2VP8F@28216|Betaproteobacteria,4AD6N@80864|Comamonadaceae	28216|Betaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_8804222_9	1100720.ALKN01000045_gene463	2.084e-25	114.0	2E5VC@1|root,330JE@2|Bacteria,1R373@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8804222_7	1144319.PMI16_04564	2.406e-39	153.0	COG0824@1|root,COG0824@2|Bacteria,1RG6B@1224|Proteobacteria,2VTAU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	-Thioesterase	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
HKD3_k127_8804222_2	1095769.CAHF01000011_gene2458	4.645e-155	507.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VKG2@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	ybiC	-	-	ko:K13574	-	-	-	-	ko00000,ko01000	-	-	-	Ldh_2
HKD3_k127_8804222_6	663610.JQKO01000009_gene337	9.824e-41	160.0	COG4636@1|root,COG4636@2|Bacteria,1RJC2@1224|Proteobacteria,2UIM9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD3_k127_8804222_0	365046.Rta_04250	1.078e-167	539.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VIE2@28216|Betaproteobacteria,4ACB3@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_8804222_8	365046.Rta_04240	1.973e-30	125.0	COG3090@1|root,COG3090@2|Bacteria,1NDFB@1224|Proteobacteria,2W4QP@28216|Betaproteobacteria,4AIFI@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_8859157_16	1286093.C266_08410	1.17e-13	84.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1K7M9@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD3_k127_8859157_4	402626.Rpic_2563	1.579e-149	484.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,1K1ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HKD3_k127_8859157_10	1265502.KB905931_gene1733	1.032e-87	292.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria,4AA0S@80864|Comamonadaceae	28216|Betaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD3_k127_8859157_2	1218084.BBJK01000055_gene4305	7.135e-229	717.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,1K2BC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_8859157_9	1031711.RSPO_c01104	6.342e-108	355.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,1K1AC@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	tsaC	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_8859157_11	795666.MW7_2431	1.608e-79	283.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,1K00M@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM HemY domain protein	hemY	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_12
HKD3_k127_8859157_14	640081.Dsui_1600	9.883e-56	209.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,2VMG1@28216|Betaproteobacteria,2KW9U@206389|Rhodocyclales	206389|Rhodocyclales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	hemX	-	2.1.1.107	ko:K02496	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
HKD3_k127_8859157_15	1502852.FG94_02314	6.2e-20	104.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,4735Z@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD3_k127_8859157_8	93220.LV28_21150	7.13e-118	387.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,1K11P@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD3_k127_8859157_7	887898.HMPREF0551_1015	1.227e-134	433.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,1KAB7@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	LytTr DNA-binding domain	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD3_k127_8859157_12	1163617.SCD_n02801	4.329e-68	262.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
HKD3_k127_8859157_1	93220.LV28_21135	2.694e-237	743.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,1K0Y8@119060|Burkholderiaceae	28216|Betaproteobacteria	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD3_k127_8859157_5	748247.AZKH_1013	2.021e-146	497.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2VH1J@28216|Betaproteobacteria,2KURQ@206389|Rhodocyclales	206389|Rhodocyclales	C	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_8859157_6	1429916.X566_18245	5.062e-145	488.0	COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,3JQN4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Part of the tripartite ATP-independent periplasmic (TRAP) transport system	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
HKD3_k127_8859157_3	1038860.AXAP01000008_gene5990	2.851e-220	693.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3JUDS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_8859157_13	420662.Mpe_A2833	3.485e-66	231.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2VRCB@28216|Betaproteobacteria,1KKVD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Tripartite ATP-independent periplasmic transporter DctQ	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_8859157_0	1265502.KB905931_gene1730	8.099e-270	839.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4AAQ4@80864|Comamonadaceae	28216|Betaproteobacteria	C	pyridine nucleotide-disulphide oxidoreductase dimerisation region	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
HKD3_k127_8885695_4	1392838.AWNM01000016_gene3233	3.959e-78	271.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,3T24R@506|Alcaligenaceae	28216|Betaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD3_k127_8885695_3	626418.bglu_1g04200	6.629e-160	523.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,1K2D1@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD3_k127_8885695_2	360910.BAV0296	1.106e-166	534.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,2VHNC@28216|Betaproteobacteria,3T1IA@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD3_k127_8885695_1	1173027.Mic7113_4934	4.686e-251	790.0	COG1171@1|root,COG1171@2|Bacteria,1G22X@1117|Cyanobacteria,1H9M3@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.ilvA	PALP,Thr_dehydrat_C
HKD3_k127_8885695_5	887898.HMPREF0551_2569	1.717e-64	224.0	COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,2VUM5@28216|Betaproteobacteria,1K7IU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	yqaA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD3_k127_8885695_0	1366050.N234_02135	0.0	1397.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD3_k127_8903846_18	330214.NIDE1435	2.81e-13	73.0	COG3439@1|root,COG3439@2|Bacteria	2|Bacteria	D	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD3_k127_8903846_6	614083.AWQR01000055_gene1969	1.505e-121	419.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,4A9MA@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
HKD3_k127_8903846_9	795666.MW7_0759	4.688e-103	339.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VIKP@28216|Betaproteobacteria,1K47S@119060|Burkholderiaceae	28216|Betaproteobacteria	V	abc transporter	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
HKD3_k127_8903846_3	795666.MW7_0760	5.172e-163	536.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria	28216|Betaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_8903846_7	614083.AWQR01000003_gene2919	7.922e-119	392.0	COG0596@1|root,COG0596@2|Bacteria,1QXWE@1224|Proteobacteria,2WHZX@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD3_k127_8903846_5	365044.Pnap_3471	5.558e-141	462.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2VI41@28216|Betaproteobacteria,4AAN5@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM Phospholipase D Transphosphatidylase	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD3_k127_8903846_15	365044.Pnap_1259	2.957e-55	198.0	COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2VSDN@28216|Betaproteobacteria,4ADQQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF	-	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec,DUF411
HKD3_k127_8903846_4	1235457.C404_12795	1.833e-157	505.0	COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,1JZSR@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_8903846_8	29581.BW37_03982	8.22e-114	378.0	COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2VHX0@28216|Betaproteobacteria,473YB@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_8903846_2	640081.Dsui_0441	5.834e-197	632.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales	206389|Rhodocyclales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD3_k127_8903846_12	1175306.GWL_45600	8.332e-81	288.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,473WN@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD3_k127_8903846_11	1348657.M622_11185	1.573e-85	304.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2VHHC@28216|Betaproteobacteria,2KUFF@206389|Rhodocyclales	206389|Rhodocyclales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD3_k127_8903846_10	887898.HMPREF0551_1698	7.018e-100	343.0	COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,1K3TD@119060|Burkholderiaceae	28216|Betaproteobacteria	M	periplasmic protein TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
HKD3_k127_8903846_0	887898.HMPREF0551_1699	1.941e-214	685.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1JZN8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	ribonuclease II	rnb	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HKD3_k127_8903846_13	663610.JQKO01000005_gene2468	6.938e-73	258.0	COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,3NB3U@45404|Beijerinckiaceae	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_39710	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_8903846_17	1121033.AUCF01000006_gene4102	2.537e-37	162.0	COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,2U7H0@28211|Alphaproteobacteria,2JSQY@204441|Rhodospirillales	204441|Rhodospirillales	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD3_k127_8903846_14	1005048.CFU_0783	1.867e-68	261.0	COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,2VRCD@28216|Betaproteobacteria,473QG@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0227)	yqiA	-	-	ko:K07000	-	-	-	-	ko00000	-	-	-	UPF0227
HKD3_k127_8903846_1	62928.azo0868	1.218e-203	646.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,2KUZ4@206389|Rhodocyclales	206389|Rhodocyclales	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_8903846_16	522306.CAP2UW1_0062	7.397e-49	183.0	COG2271@1|root,COG2271@2|Bacteria,1PND6@1224|Proteobacteria,2WGS2@28216|Betaproteobacteria,1KR4T@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_8981464_0	1218075.BAYA01000004_gene1258	8.722e-248	779.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,1K2GQ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD3_k127_8981464_9	257310.BB4939	6.616e-32	135.0	COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,3T3VA@506|Alcaligenaceae	28216|Betaproteobacteria	D	Sporulation related domain	ftsN	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD3_k127_8981464_7	1265502.KB905937_gene2589	1.64e-59	214.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria,4ADS0@80864|Comamonadaceae	28216|Betaproteobacteria	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin
HKD3_k127_8981464_4	1218076.BAYB01000024_gene4280	1.702e-77	273.0	COG0300@1|root,COG0300@2|Bacteria,1PNDU@1224|Proteobacteria,2VIWD@28216|Betaproteobacteria,1K056@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	wcbP	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_8981464_2	76114.ebA3624	8.522e-81	289.0	COG4558@1|root,COG4558@2|Bacteria,1QVI8@1224|Proteobacteria,2WGSH@28216|Betaproteobacteria,2KURN@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HKD3_k127_8981464_5	62928.azo0179	4.204e-71	258.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KUPW@206389|Rhodocyclales	206389|Rhodocyclales	DM	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD3_k127_8981464_6	522306.CAP2UW1_0584	6.168e-68	243.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,1KPYC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD3_k127_8981464_10	1123393.KB891331_gene2974	5.166e-25	108.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,1KRU1@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Uncharacterised protein family UPF0102	-	-	-	-	-	-	-	-	-	-	-	-	UPF0102
HKD3_k127_8981464_1	535289.Dtpsy_1914	3.998e-90	311.0	2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae	28216|Betaproteobacteria	M	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
HKD3_k127_8981464_3	1144325.PMI22_00261	1.582e-80	279.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K14057	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_8981464_8	1298864.AUEQ01000012_gene909	1.173e-49	181.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,235VD@1762|Mycobacteriaceae	201174|Actinobacteria	P	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
HKD3_k127_9014957_0	1304885.AUEY01000002_gene350	6.451e-246	763.0	COG3119@1|root,COG3119@2|Bacteria,1PFYE@1224|Proteobacteria,43A2J@68525|delta/epsilon subdivisions,2WQC7@28221|Deltaproteobacteria,2MNWS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD3_k127_9014957_3	1304885.AUEY01000002_gene351	1.847e-154	495.0	COG4313@1|root,COG4313@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD3_k127_9014957_11	1331060.RLDS_21495	1.253e-50	205.0	2DBQZ@1|root,2ZAHJ@2|Bacteria,1MXQ6@1224|Proteobacteria,2TVE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B_2
HKD3_k127_9014957_17	1198452.Jab_2c28030	0.0004003	48.0	2CGYM@1|root,33G21@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9014957_13	545696.HOLDEFILI_03285	2.086e-26	123.0	COG1196@1|root,COG1196@2|Bacteria,1TPU3@1239|Firmicutes,3VPCW@526524|Erysipelotrichia	526524|Erysipelotrichia	D	MobA MobL family protein	-	-	-	-	-	-	-	-	-	-	-	-	MobA_MobL
HKD3_k127_9014957_1	1502852.FG94_00075	4.97e-167	548.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,472YU@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD3_k127_9014957_10	1245471.PCA10_07040	5.542e-55	201.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,1TCA7@1236|Gammaproteobacteria,1YK48@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9014957_15	225937.HP15_106	2.219e-24	119.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,1SVEG@1236|Gammaproteobacteria,46D44@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Porin subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
HKD3_k127_9014957_8	1279038.KB907340_gene1536	1.029e-86	315.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria,2JQI8@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD3_k127_9014957_12	1492922.GY26_00565	1.371e-33	132.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,1T799@1236|Gammaproteobacteria,1JB2F@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Lipid A Biosynthesis N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
HKD3_k127_9014957_4	1123393.KB891333_gene2554	5.98e-128	426.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KRDI@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_9014957_2	497964.CfE428DRAFT_6090	9.438e-161	517.0	COG4307@1|root,COG4307@2|Bacteria,46U5T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HKD3_k127_9014957_7	987059.RBXJA2T_09392	4.811e-90	325.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria,1KMPW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD3_k127_9014957_16	1118235.CAJH01000019_gene1034	6.799e-21	94.0	COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,1SGZZ@1236|Gammaproteobacteria,1XC0C@135614|Xanthomonadales	135614|Xanthomonadales	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_9014957_14	1163407.UU7_07826	4.191e-26	115.0	2AQTF@1|root,31G1I@2|Bacteria,1QDTY@1224|Proteobacteria,1T9Z0@1236|Gammaproteobacteria,1X8GI@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9014957_6	1121015.N789_07970	1.1e-105	362.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,1RPB9@1236|Gammaproteobacteria,1XC31@135614|Xanthomonadales	135614|Xanthomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD3_k127_9014957_5	1157708.KB907462_gene903	2.049e-123	411.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,4A9SJ@80864|Comamonadaceae	28216|Betaproteobacteria	BQ	PFAM histone deacetylase superfamily	hda	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD3_k127_9014957_9	1268622.AVS7_01057	3.492e-58	211.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,4AAAJ@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM CoA-binding domain protein	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD3_k127_9066543_1	1095769.CAHF01000007_gene1651	9.275e-165	528.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VHCG@28216|Betaproteobacteria,472I0@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD3_k127_9066543_3	1123279.ATUS01000003_gene365	1.214e-39	156.0	COG3832@1|root,COG3832@2|Bacteria,1NKKP@1224|Proteobacteria,1SHSG@1236|Gammaproteobacteria,1JACX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2505)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
HKD3_k127_9066543_0	1123257.AUFV01000014_gene3416	0.0	1163.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1X2XY@135614|Xanthomonadales	135614|Xanthomonadales	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
HKD3_k127_9066543_2	887898.HMPREF0551_0695	1.733e-80	297.0	COG3170@1|root,COG3170@2|Bacteria,1QV1N@1224|Proteobacteria,2WGRZ@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Protein of unknown function (DUF1631)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631
HKD3_k127_9066543_5	864073.HFRIS_012604	2.019e-31	136.0	COG4290@1|root,COG4290@2|Bacteria,1MZEZ@1224|Proteobacteria,2VTZ7@28216|Betaproteobacteria,474X9@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Guanyl-specific ribonuclease Sa	rnaSA	-	3.1.27.3	ko:K01167	-	-	-	-	ko00000,ko01000,ko03016,ko03019	-	-	-	Ribonuclease
HKD3_k127_9066543_4	887898.HMPREF0551_0215	1.799e-36	160.0	COG2732@1|root,COG2732@2|Bacteria,1RD25@1224|Proteobacteria,2VR9C@28216|Betaproteobacteria,1K41A@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Barstar (Barnase inhibitor)	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
HKD3_k127_9066543_6	1033802.SSPSH_000149	3.664e-11	64.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD3_k127_9107343_9	556269.ACDQ01000021_gene2080	5.56e-14	85.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2VJFW@28216|Betaproteobacteria,4734F@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_9107343_6	420662.Mpe_A2225	5.877e-100	343.0	COG0179@1|root,COG0179@2|Bacteria,1QUQP@1224|Proteobacteria,2VQEI@28216|Betaproteobacteria,1KN9D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Domain of unknown function (DUF2437)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD3_k127_9107343_8	1095769.CAHF01000013_gene3212	8.617e-75	265.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,474AF@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD3_k127_9107343_3	543728.Vapar_4801	2.755e-118	409.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2VMJZ@28216|Betaproteobacteria,4AAV4@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_9107343_7	760117.JN27_08600	7.073e-75	281.0	COG2021@1|root,COG2021@2|Bacteria,1QU6N@1224|Proteobacteria,2WGNS@28216|Betaproteobacteria,472DC@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD3_k127_9107343_0	381666.H16_A2978	6.622e-226	744.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIJX@28216|Betaproteobacteria,1K4HV@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	matB	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_9107343_4	375286.mma_1709	7.748e-117	385.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4731A@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_9107343_2	1265502.KB905969_gene1232	1.034e-143	471.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2VHK0@28216|Betaproteobacteria,4A9P3@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HKD3_k127_9107343_5	795666.MW7_2494	8.799e-116	381.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria,1K2AG@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD3_k127_9107343_1	977880.RALTA_A2461	5.382e-207	651.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,1JZV8@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD3_k127_935824_9	1123377.AUIV01000001_gene948	3.783e-08	59.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_935824_8	1321781.HMPREF1985_02304	2.294e-11	77.0	COG0517@1|root,COG0517@2|Bacteria,1VA1X@1239|Firmicutes,4H57A@909932|Negativicutes	909932|Negativicutes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_935824_5	1121439.dsat_0674	1.672e-125	422.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,42NYV@68525|delta/epsilon subdivisions,2WPI0@28221|Deltaproteobacteria,2MFWD@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_935824_2	1454004.AW11_03482	1.444e-236	751.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD3_k127_935824_0	398578.Daci_0774	1.581e-267	841.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2VJ5N@28216|Betaproteobacteria,4AD5B@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Alkyl sulfatase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,GMC_oxred_C,GMC_oxred_N,Lactamase_B
HKD3_k127_935824_3	748247.AZKH_p0307	6.425e-197	637.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,2KZ15@206389|Rhodocyclales	206389|Rhodocyclales	C	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HKD3_k127_935824_1	1532557.JL37_23880	5.281e-254	792.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VQVS@28216|Betaproteobacteria,3T1F9@506|Alcaligenaceae	28216|Betaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HKD3_k127_935824_6	1123368.AUIS01000019_gene1214	1.286e-119	417.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,2NE5Q@225057|Acidithiobacillales	1236|Gammaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD3_k127_935824_7	857087.Metme_2188	3.833e-41	156.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria,1XFAS@135618|Methylococcales	135618|Methylococcales	C	PFAM 2Fe-2S -binding	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD3_k127_935824_4	292415.Tbd_2815	1.161e-158	514.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KS5H@119069|Hydrogenophilales	119069|Hydrogenophilales	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HKD3_k127_9511333_21	1198452.Jab_2c32580	1.041e-50	181.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,472M6@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD3_k127_9511333_20	83406.HDN1F_25760	5.238e-51	192.0	COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,1T20E@1236|Gammaproteobacteria,1J6P3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
HKD3_k127_9511333_7	1280950.HJO_10124	1.331e-135	438.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,43XYZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG2070 Dioxygenases related to 2-nitropropane dioxygenase	-	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
HKD3_k127_9511333_6	1415780.JPOG01000001_gene1277	9.057e-161	524.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1XA0C@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_9511333_15	1207063.P24_12747	2.146e-83	292.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2U0C9@28211|Alphaproteobacteria,2JR94@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HKD3_k127_9511333_5	439235.Dalk_5274	4.837e-189	599.0	COG1960@1|root,COG1960@2|Bacteria,1R6R2@1224|Proteobacteria,42NTR@68525|delta/epsilon subdivisions,2WKRA@28221|Deltaproteobacteria,2MIWC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase type 2 domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_9511333_3	305700.B447_16292	1.525e-272	852.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,2KY78@206389|Rhodocyclales	206389|Rhodocyclales	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_9511333_17	1156919.QWC_07014	2.072e-64	233.0	COG1414@1|root,COG1414@2|Bacteria,1R5ZB@1224|Proteobacteria,2WETN@28216|Betaproteobacteria,3T7JQ@506|Alcaligenaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD3_k127_9511333_10	631362.Thi970DRAFT_04753	1.112e-109	371.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD3_k127_9511333_2	264198.Reut_A0864	1.023e-316	989.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,1K29A@119060|Burkholderiaceae	28216|Betaproteobacteria	L	helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_9511333_22	395019.Bmul_4879	5.381e-44	175.0	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,1K2PD@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9511333_9	426114.THI_1570	2.782e-118	391.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,1KJIP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HKD3_k127_9511333_12	887898.HMPREF0551_0329	2.914e-103	342.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,1JZMK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the LOG family	yvdD_2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_9511333_0	887898.HMPREF0551_0330	0.0	1212.0	COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae	28216|Betaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD3_k127_9511333_16	1144319.PMI16_01443	4.895e-81	278.0	COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,2VN69@28216|Betaproteobacteria,4724R@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Divalent heavy-metal cations transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
HKD3_k127_9511333_11	887898.HMPREF0551_0345	1.718e-104	348.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,1K2GD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD3_k127_9511333_18	1366050.N234_15490	4.528e-63	226.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,1K4Y6@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HKD3_k127_9511333_4	977880.RALTA_A2238	4.83e-204	641.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,1K22K@119060|Burkholderiaceae	28216|Betaproteobacteria	P	rieske 2fe-2s	alcE	-	1.14.15.7	ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HKD3_k127_9511333_23	264198.Reut_A0880	6.067e-22	99.0	COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,1K9WF@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD3_k127_9511333_13	795666.MW7_3015	9.185e-99	332.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,1K1CK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD3_k127_9511333_1	887898.HMPREF0551_0350	2.652e-320	989.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1K2IB@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD3_k127_9511333_14	882378.RBRH_01160	1.218e-93	314.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,1K2E8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD3_k127_9511333_19	1244869.H261_22303	1.832e-60	213.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2U9QR@28211|Alphaproteobacteria,2JTT7@204441|Rhodospirillales	204441|Rhodospirillales	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD3_k127_9511333_8	1158292.JPOE01000002_gene3146	2.413e-122	400.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,2VIMQ@28216|Betaproteobacteria,1KKCP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	SbmA/BacA-like family	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
HKD3_k127_955083_9	1000565.METUNv1_00386	4.68e-61	211.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,2KVUM@206389|Rhodocyclales	206389|Rhodocyclales	P	phosphate transport system	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD3_k127_955083_3	1304883.KI912532_gene265	9.292e-134	431.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,2KUH7@206389|Rhodocyclales	206389|Rhodocyclales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD3_k127_955083_10	279714.FuraDRAFT_1061	4.245e-53	196.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,2KPQP@206351|Neisseriales	206351|Neisseriales	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD3_k127_955083_4	1121035.AUCH01000012_gene2989	8.603e-99	347.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,2KVEJ@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF3329,HATPase_c,HisKA,PAS_8
HKD3_k127_955083_7	497321.C664_13914	6.701e-86	301.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2VIT4@28216|Betaproteobacteria,2KUNU@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_955083_14	768066.HELO_4407	3.871e-13	77.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SGH0@1236|Gammaproteobacteria,1XMPV@135619|Oceanospirillales	135619|Oceanospirillales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD3_k127_955083_0	1095769.CAHF01000014_gene2841	1.673e-182	584.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2VI4S@28216|Betaproteobacteria,4766C@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD3_k127_955083_2	887898.HMPREF0551_1583	2.029e-150	485.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2VIN9@28216|Betaproteobacteria,1K166@119060|Burkholderiaceae	28216|Betaproteobacteria	M	udp-glucose 4-epimerase	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD3_k127_955083_5	1095769.CAHF01000013_gene3343	8.466e-94	314.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,2VQ8U@28216|Betaproteobacteria,473B3@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Deoxynucleoside kinase	dgk	-	-	-	-	-	-	-	-	-	-	-	dNK
HKD3_k127_955083_11	204773.HEAR2639	5.709e-50	191.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2VSWS@28216|Betaproteobacteria,474CQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HKD3_k127_955083_12	420662.Mpe_A3019	3.25e-47	191.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2VSE2@28216|Betaproteobacteria,1KMF0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD3_k127_955083_1	667632.KB890167_gene1627	2.876e-168	546.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2VHY5@28216|Betaproteobacteria,1K2BR@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HKD3_k127_955083_6	626418.bglu_1g06410	3.671e-89	299.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,1K0JT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	HAD-superfamily hydrolase, subfamily IB (PSPase-like)	serB2	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD3_k127_955083_8	795666.MW7_2699	6.363e-63	224.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,1K0WU@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Belongs to the DnaA family	hda	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
HKD3_k127_955083_13	946483.Cenrod_1030	8.025e-34	143.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,4AA2M@80864|Comamonadaceae	28216|Betaproteobacteria	F	AIR synthase related protein domain protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
## 2921 queries scanned
## Total time (seconds): 22.219297409057617
## Rate: 131.46 q/s