## Sat Nov 16 17:03:47 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin10/HSJS_3_bin.22.fa -m mmseqs --itype genome -o HSJS_3_bin.22 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HSJS_3_bin.22 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs HSJS3_k127_10080228_26 379066.GAU_2146 3.329e-05 51.0 COG0760@1|root,COG0760@2|Bacteria,1ZSU2@142182|Gemmatimonadetes 142182|Gemmatimonadetes O SurA N-terminal domain - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3,SurA_N_3 HSJS3_k127_10080228_25 485915.Dret_1772 3.483e-06 59.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2M7YN@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM PpiC-type peptidyl-prolyl cis-trans isomerase nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 HSJS3_k127_10080228_0 861299.J421_3747 2.775e-288 923.0 COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF HSJS3_k127_10080228_14 861299.J421_3748 1.8e-47 194.0 COG1572@1|root,COG1572@2|Bacteria 2|Bacteria NU bacterial-type flagellum-dependent cell motility - - 3.4.21.10 ko:K01317 - - - - ko00000,ko01000,ko01002,ko04131 - - - BatA,CARDB,F5_F8_type_C,HemolysinCabind,Laminin_G_3,NIDO,VWA_2 HSJS3_k127_10080228_8 1379270.AUXF01000003_gene3696 1.216e-83 288.0 COG1721@1|root,COG1721@2|Bacteria,1ZT0H@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 HSJS3_k127_10080228_9 700598.Niako_4356 1.17e-66 247.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1IQ2M@117747|Sphingobacteriia 976|Bacteroidetes S peptidase - - - - - - - - - - - - PA,Peptidase_M28 HSJS3_k127_10080228_24 401053.AciPR4_3009 8.413e-07 57.0 COG4980@1|root,COG4980@2|Bacteria,3Y5IA@57723|Acidobacteria,2JK01@204432|Acidobacteriia 204432|Acidobacteriia S YtxH-like protein - - - - - - - - - - - - YtxH HSJS3_k127_10080228_22 861299.J421_2878 2.566e-30 134.0 COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB HSJS3_k127_10080228_17 429009.Adeg_1493 9.892e-44 164.0 COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,42GC6@68295|Thermoanaerobacterales 186801|Clostridia J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB HSJS3_k127_10080228_19 1297742.A176_00645 1.796e-32 140.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM cell wall hydrolase autolysin amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,TPR_6 HSJS3_k127_10080228_12 429009.Adeg_0374 5.407e-49 185.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,42GEQ@68295|Thermoanaerobacterales 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 HSJS3_k127_10080228_6 338966.Ppro_2629 1.197e-90 310.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,43TBH@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh HSJS3_k127_10080228_10 671143.DAMO_2553 3.784e-58 219.0 COG0284@1|root,COG0284@2|Bacteria,2NQYX@2323|unclassified Bacteria 2|Bacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 OMPdecase HSJS3_k127_10080228_23 371042.NG99_01000 1.031e-29 120.0 COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,1S8YP@1236|Gammaproteobacteria,3X6TC@551|Erwinia 1236|Gammaproteobacteria S Transglycosylase associated protein yeaQ - - - - - - - - - - - Transgly_assoc HSJS3_k127_10080228_7 1297742.A176_00099 2.234e-85 293.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,2YUHA@29|Myxococcales 28221|Deltaproteobacteria C NAD(P)H quinone oxidoreductase, PIG3 family - - - - - - - - - - - - ADH_N,ADH_zinc_N HSJS3_k127_10080228_1 290397.Adeh_1417 7.684e-206 658.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42PMK@68525|delta/epsilon subdivisions,2X5G7@28221|Deltaproteobacteria,2Z35F@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N HSJS3_k127_10080228_2 251229.Chro_0265 1.239e-160 524.0 COG1282@1|root,COG1282@2|Bacteria,1G2AX@1117|Cyanobacteria,3VI45@52604|Pleurocapsales 1117|Cyanobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB HSJS3_k127_10080228_20 237368.SCABRO_00861 1.134e-31 130.0 COG3288@1|root,COG3288@2|Bacteria,2J0SW@203682|Planctomycetes 203682|Planctomycetes C COG3288 NAD NADP transhydrogenase alpha subunit - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM HSJS3_k127_10080228_5 1170562.Cal6303_3049 1.265e-111 377.0 COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1HJ2V@1161|Nostocales 1117|Cyanobacteria C PFAM Alanine dehydrogenase PNT, C-terminal domain pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N HSJS3_k127_10080228_18 1379270.AUXF01000002_gene1700 5.529e-35 141.0 28NN4@1|root,2ZBNJ@2|Bacteria,1ZTTM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_10080228_21 861299.J421_2642 1.046e-30 131.0 COG1651@1|root,COG1651@2|Bacteria,1ZTVX@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin - - - - - - - - - - - - Thioredoxin_4 HSJS3_k127_10080228_3 379066.GAU_3087 2.652e-141 471.0 COG0076@1|root,COG0076@2|Bacteria,1ZSZN@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC HSJS3_k127_10080228_16 644966.Tmar_1824 8.744e-44 183.0 COG0551@1|root,COG1112@1|root,COG1196@1|root,COG1502@1|root,COG0551@2|Bacteria,COG1112@2|Bacteria,COG1196@2|Bacteria,COG1502@2|Bacteria,1UNF1@1239|Firmicutes,24HXY@186801|Clostridia,3WCRG@538999|Clostridiales incertae sedis 186801|Clostridia L AAA domain - - - - - - - - - - - - AAA_11,AAA_12,zf-C4_Topoisom HSJS3_k127_10080228_13 1117647.M5M_03730 2.605e-48 177.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1J6EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family UPF0047 yjbQ - - - - - - - - - - - UPF0047 HSJS3_k127_10080228_15 439235.Dalk_0806 7.103e-46 169.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,42SMU@68525|delta/epsilon subdivisions,2WP4P@28221|Deltaproteobacteria,2MK67@213118|Desulfobacterales 28221|Deltaproteobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase HSJS3_k127_10080228_11 379066.GAU_2420 1.284e-54 198.0 COG0424@1|root,COG0424@2|Bacteria,1ZTP7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf HSJS3_k127_10080228_4 1041142.ATTP01000004_gene4518 7.551e-126 413.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,4B8DP@82115|Rhizobiaceae 28211|Alphaproteobacteria C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N HSJS3_k127_10602449_8 983917.RGE_37230 1.055e-83 295.0 COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,2VPB2@28216|Betaproteobacteria,1KN5F@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C HSJS3_k127_10602449_18 448385.sce3014 7.86e-32 142.0 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,42WKH@68525|delta/epsilon subdivisions,2WSGE@28221|Deltaproteobacteria,2YVQV@29|Myxococcales 28221|Deltaproteobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N HSJS3_k127_10602449_7 1254432.SCE1572_18300 2.25e-84 290.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,42S34@68525|delta/epsilon subdivisions,2X5AY@28221|Deltaproteobacteria,2Z34Z@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the MenA family. Type 1 subfamily menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA HSJS3_k127_10602449_1 987059.RBXJA2T_13966 2.656e-135 436.0 COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2VJ36@28216|Betaproteobacteria,1KKKJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661,ko:K07536 ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220 M00116,M00540 R05592,R07263 RC01429,RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 HSJS3_k127_10602449_3 1254432.SCE1572_18295 1.214e-115 403.0 COG1165@1|root,COG1165@2|Bacteria,1MVMZ@1224|Proteobacteria,42PNC@68525|delta/epsilon subdivisions,2WKSZ@28221|Deltaproteobacteria,2YUJF@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N HSJS3_k127_10602449_13 502025.Hoch_5716 4.531e-55 211.0 COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,42S21@68525|delta/epsilon subdivisions,2WNRS@28221|Deltaproteobacteria,2YV7S@29|Myxococcales 28221|Deltaproteobacteria HQ chorismate binding enzyme menF - 5.4.4.2 ko:K01851,ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind HSJS3_k127_10602449_4 1192034.CAP_8700 2.399e-105 351.0 COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,42MU4@68525|delta/epsilon subdivisions,2WJ8Y@28221|Deltaproteobacteria,2YXNS@29|Myxococcales 28221|Deltaproteobacteria E phospho-2-dehydro-3-deoxyheptonate aldolase aroG-2 - 2.5.1.54,5.4.99.5 ko:K01626,ko:K03856,ko:K04516,ko:K13853 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022,M00024,M00025 R01715,R01826 RC00435,RC03116 ko00000,ko00001,ko00002,ko01000 - - - CM_2,DAHP_synth_1 HSJS3_k127_10602449_6 118161.KB235922_gene2453 1.423e-93 319.0 COG3191@1|root,COG3191@2|Bacteria 2|Bacteria EQ aminopeptidase activity - - - - - - - - - - - - Peptidase_S58 HSJS3_k127_10602449_2 379066.GAU_3550 6.709e-129 429.0 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF HSJS3_k127_10602449_15 1236973.JCM9157_155 1.458e-41 168.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,1ZCWN@1386|Bacillus 91061|Bacilli P Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,Rhodanese HSJS3_k127_10602449_0 1089550.ATTH01000001_gene1033 2.446e-144 477.0 COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,1FJWA@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Aminopeptidase P, N-terminal domain pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 HSJS3_k127_10602449_11 1121013.P873_06340 5.065e-65 244.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1X3PM@135614|Xanthomonadales 135614|Xanthomonadales E acid dehydrogenase - - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO HSJS3_k127_10602449_12 1254432.SCE1572_20480 1.76e-59 219.0 COG3386@1|root,COG3386@2|Bacteria,1R1IS@1224|Proteobacteria,43D9R@68525|delta/epsilon subdivisions,2WXHS@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - HSJS3_k127_10602449_9 1120970.AUBZ01000031_gene3127 1.245e-74 256.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,466CT@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx HSJS3_k127_10602449_5 861299.J421_1521 1.532e-94 317.0 COG0614@1|root,COG0614@2|Bacteria 2|Bacteria P abc-type fe3 -hydroxamate transport system, periplasmic component fecB - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 HSJS3_k127_10602449_20 309807.SRU_2724 8.894e-18 88.0 COG1073@1|root,COG1073@2|Bacteria,4NFRN@976|Bacteroidetes,1FJSE@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S BAAT / Acyl-CoA thioester hydrolase C terminal - - - ko:K06889 - - - - ko00000 - - - BAAT_C,Hydrolase_4 HSJS3_k127_10602449_10 1123278.KB893559_gene2996 1.543e-73 260.0 COG0438@1|root,COG0438@2|Bacteria,4NETA@976|Bacteroidetes,47JD3@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 HSJS3_k127_10602449_16 493475.GARC_4186 2.044e-36 140.0 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,467E8@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0145 family - - - - - - - - - - - - YbjQ_1 HSJS3_k127_10602449_17 880073.Calab_0082 1.447e-32 134.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_10602449_14 1120953.AUBH01000020_gene3321 1.649e-46 178.0 COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,1SAKR@1236|Gammaproteobacteria,46B30@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - HSJS3_k127_1063928_15 861299.J421_0685 1.092e-55 199.0 COG1670@1|root,COG1670@2|Bacteria,1ZUZX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 HSJS3_k127_1063928_23 1183438.GKIL_1014 2.635e-25 109.0 COG1670@1|root,COG1670@2|Bacteria,1GR52@1117|Cyanobacteria 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - 2.3.1.82 ko:K18816 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1 HSJS3_k127_1063928_13 1382356.JQMP01000003_gene1477 1.744e-67 233.0 COG2080@1|root,COG2080@2|Bacteria,2GBQV@200795|Chloroflexi,27Y9S@189775|Thermomicrobia 189775|Thermomicrobia C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 HSJS3_k127_1063928_0 196490.AUEZ01000042_gene7227 0.0 1049.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JSZE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 HSJS3_k127_1063928_24 324602.Caur_3470 1.333e-23 107.0 COG3170@1|root,COG3427@1|root,COG3170@2|Bacteria,COG3427@2|Bacteria,2G6U6@200795|Chloroflexi,376AP@32061|Chloroflexia 32061|Chloroflexia NU PFAM carbon monoxide dehydrogenase subunit G - - - ko:K09386 - - - - ko00000 - - - COXG HSJS3_k127_1063928_12 926569.ANT_05690 1.725e-79 276.0 COG1319@1|root,COG1319@2|Bacteria 2|Bacteria C xanthine dehydrogenase activity - - 1.2.5.3,1.5.99.4 ko:K03519,ko:K19818 ko00760,ko01120,map00760,map01120 M00810 R02860,R07946,R11168 RC00589,RC02800 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 HSJS3_k127_1063928_5 234267.Acid_7658 1.065e-142 481.0 COG1953@1|root,COG1953@2|Bacteria,3Y2FU@57723|Acidobacteria 57723|Acidobacteria FH PFAM Permease for cytosine purines, uracil, thiamine, allantoin - - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur HSJS3_k127_1063928_3 251221.35211686 5.062e-170 550.0 COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria 1117|Cyanobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - ko:K00666,ko:K18660 ko00280,map00280 - R03383 RC00004,RC00137 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C HSJS3_k127_1063928_6 309801.trd_0580 1.253e-137 441.0 COG1878@1|root,COG1878@2|Bacteria,2GBDZ@200795|Chloroflexi,27Z1S@189775|Thermomicrobia 189775|Thermomicrobia S Putative cyclase - - - - - - - - - - - - Cyclase HSJS3_k127_1063928_7 28444.JODQ01000001_gene2125 4.092e-110 372.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4EHYD@85012|Streptosporangiales 201174|Actinobacteria J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase HSJS3_k127_1063928_14 1004149.AFOE01000007_gene1263 4.82e-61 219.0 COG4845@1|root,COG4845@2|Bacteria,4NJJH@976|Bacteroidetes,1I539@117743|Flavobacteriia 976|Bacteroidetes V Chloramphenicol acetyltransferase - - 2.3.1.28 ko:K19271 - - - - br01600,ko00000,ko01000,ko01504 - - - CAT HSJS3_k127_1063928_11 247490.KSU1_B0265 2.869e-84 300.0 COG2010@1|root,COG2010@2|Bacteria,2IZN4@203682|Planctomycetes 203682|Planctomycetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3,EB_dh HSJS3_k127_1063928_16 237368.SCABRO_00341 1.413e-50 188.0 COG2010@1|root,COG2010@2|Bacteria,2J291@203682|Planctomycetes 203682|Planctomycetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 HSJS3_k127_1063928_17 247490.KSU1_B0267 1.904e-49 190.0 COG2010@1|root,COG2010@2|Bacteria,2IXPN@203682|Planctomycetes 203682|Planctomycetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C HSJS3_k127_1063928_2 247490.KSU1_B0268 5.549e-191 616.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 HSJS3_k127_1063928_20 237368.SCABRO_00345 1.002e-44 172.0 COG3794@1|root,COG3794@2|Bacteria,2J06V@203682|Planctomycetes 203682|Planctomycetes C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - fn3_3 HSJS3_k127_1063928_25 1340493.JNIF01000003_gene3977 9.934e-05 55.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c - - - - - - - - - - - - PSCyt1,PSCyt2,PSD1 HSJS3_k127_1063928_10 1089550.ATTH01000001_gene1476 4.559e-94 326.0 COG3391@1|root,COG3391@2|Bacteria,4PF0H@976|Bacteroidetes,1FJY5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S amine dehydrogenase activity - - - - - - - - - - - - - HSJS3_k127_1063928_18 1049564.TevJSym_ac00630 6.016e-49 185.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 HSJS3_k127_1063928_21 1313421.JHBV01000039_gene2728 2.061e-41 156.0 294EW@1|root,2ZRUR@2|Bacteria,4NPA3@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF1569) - - - - - - - - - - - - DUF1569 HSJS3_k127_1063928_22 1386089.N865_19290 1.102e-32 136.0 COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria,4FIIB@85021|Intrasporangiaceae 201174|Actinobacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.11 ko:K03428 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R04237 RC00003,RC00460 ko00000,ko00001,ko01000 - - - Methyltransf_11,Methyltransf_25 HSJS3_k127_1063928_8 1049564.TevJSym_al00220 6.52e-107 362.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,1J7IW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_1063928_9 1167006.UWK_03278 7.301e-101 335.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WN39@28221|Deltaproteobacteria,2MKUD@213118|Desulfobacterales 28221|Deltaproteobacteria M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like HSJS3_k127_1063928_1 1049564.TevJSym_ca00050 2.133e-232 743.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL HSJS3_k127_1063928_19 637390.AFOH01000044_gene2203 5.767e-45 173.0 COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria,1S8SN@1236|Gammaproteobacteria,2NCD9@225057|Acidithiobacillales 225057|Acidithiobacillales K Bacterial transcriptional repressor C-terminal - - - - - - - - - - - - TetR_C_13,TetR_N HSJS3_k127_1063928_4 1026882.MAMP_01780 1.269e-150 482.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,460E7@72273|Thiotrichales 72273|Thiotrichales E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP HSJS3_k127_1168873_18 69395.JQLZ01000003_gene436 6.962e-06 53.0 COG5349@1|root,COG5349@2|Bacteria,1N0PN@1224|Proteobacteria,2UBSH@28211|Alphaproteobacteria,2KIY8@204458|Caulobacterales 204458|Caulobacterales S Protein of unknown function (DUF983) - - - - - - - - - - - - DUF983 HSJS3_k127_1168873_2 1089550.ATTH01000001_gene1477 1.226e-150 497.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1FIMC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S repeat protein - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_1168873_3 1089550.ATTH01000001_gene1477 3.244e-141 463.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1FIMC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S repeat protein - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_1168873_0 861299.J421_3164 5.655e-263 825.0 COG0459@1|root,COG0459@2|Bacteria,1ZTC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 HSJS3_k127_1168873_15 1519464.HY22_02515 1.001e-34 136.0 COG0234@1|root,COG0234@2|Bacteria,1FE2T@1090|Chlorobi 1090|Chlorobi J Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 HSJS3_k127_1168873_13 1499967.BAYZ01000028_gene1364 4.044e-37 159.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - SnoaL_3 HSJS3_k127_1168873_1 644966.Tmar_0901 4.193e-203 661.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis 186801|Clostridia C TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig HSJS3_k127_1168873_10 105425.BBPL01000018_gene55 2.017e-58 212.0 COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,2NEVV@228398|Streptacidiphilus 201174|Actinobacteria K Type III pantothenate kinase coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase HSJS3_k127_1168873_16 635013.TherJR_0220 3.203e-34 147.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,260CI@186807|Peptococcaceae 186801|Clostridia HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 HSJS3_k127_1168873_12 555088.DealDRAFT_2974 1.305e-47 181.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,42JXF@68298|Syntrophomonadaceae 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA HSJS3_k127_1168873_5 379066.GAU_1532 2.971e-132 447.0 COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1ZT2W@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase 4-like - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 HSJS3_k127_1168873_11 379066.GAU_1531 8.167e-56 207.0 COG0324@1|root,COG0324@2|Bacteria,1ZTBB@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT HSJS3_k127_1168873_6 1379698.RBG1_1C00001G1139 3.481e-115 397.0 COG0323@1|root,COG0323@2|Bacteria,2NNP7@2323|unclassified Bacteria 2|Bacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C HSJS3_k127_1168873_9 402881.Plav_3114 4.549e-59 213.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,1JNCK@119043|Rhodobiaceae 28211|Alphaproteobacteria L TatD related DNase tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase HSJS3_k127_1168873_8 1232410.KI421418_gene2299 2.603e-71 252.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria,43RZY@69541|Desulfuromonadales 28221|Deltaproteobacteria U SecD/SecF GG Motif secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG HSJS3_k127_1168873_4 861299.J421_3192 7.019e-135 449.0 COG0342@1|root,COG0342@2|Bacteria,1ZTBW@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG HSJS3_k127_1168873_7 2340.JV46_09960 2.121e-113 379.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4I6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C HSJS3_k127_1168873_14 554065.XP_005845260.1 6.62e-37 143.0 COG1028@1|root,KOG1208@2759|Eukaryota,37Q3T@33090|Viridiplantae,34HUG@3041|Chlorophyta 3041|Chlorophyta Q Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.300 ko:K11153,ko:K11162 ko00830,ko01100,map00830,map01100 - R08379,R08383 RC00649 ko00000,ko00001,ko01000 - - - adh_short HSJS3_k127_1223806_0 1122604.JONR01000004_gene852 3.234e-60 233.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_1223806_1 272569.rrnAC0216 2.832e-19 89.0 arCOG04557@1|root,arCOG04557@2157|Archaea,2XZYI@28890|Euryarchaeota,23XGW@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - HSJS3_k127_131395_0 518766.Rmar_2049 1.442e-145 480.0 COG1506@1|root,COG2706@1|root,COG1506@2|Bacteria,COG2706@2|Bacteria,4PIC9@976|Bacteroidetes,1FKAR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E 6-phosphogluconolactonase activity - - - - - - - - - - - - - HSJS3_k127_131395_2 575588.ACPN01000055_gene2202 1.946e-06 57.0 COG2155@1|root,COG2155@2|Bacteria,1N77I@1224|Proteobacteria,1SHMF@1236|Gammaproteobacteria,3NPGK@468|Moraxellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF378) - - - ko:K09779 - - - - ko00000 - - - DUF378 HSJS3_k127_131395_1 661478.OP10G_0324 6.725e-28 114.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - - - - - - - - - - - Aminotran_1_2 HSJS3_k127_1356601_15 28444.JODQ01000008_gene1046 3.511e-83 284.0 COG5276@1|root,COG5276@2|Bacteria,2GMSY@201174|Actinobacteria,4EI3T@85012|Streptosporangiales 201174|Actinobacteria S LVIVD repeat - - - - - - - - - - - - LVIVD HSJS3_k127_1356601_27 291985.CCSI01000007_gene506 2.753e-34 139.0 COG3544@1|root,COG3544@2|Bacteria,1NTI3@1224|Proteobacteria,2UMCM@28211|Alphaproteobacteria,2K3DW@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 HSJS3_k127_1356601_44 1189619.pgond44_14813 1.312e-05 55.0 2E3AK@1|root,2ZC4K@2|Bacteria,4NMMM@976|Bacteroidetes,1IIAS@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_1356601_18 29306.JOBE01000001_gene2614 8.605e-68 244.0 COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos HSJS3_k127_1356601_39 264198.Reut_B5735 6.296e-08 64.0 2ECBG@1|root,3369V@2|Bacteria,1N8NN@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - HSJS3_k127_1356601_24 861299.J421_0735 2.02e-46 179.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0735|- S peptidyl-tyrosine sulfation - - - ko:K13992 - - - - ko00000,ko00194 - - - - HSJS3_k127_1356601_45 1101195.Meth11DRAFT_0475 1.567e-05 53.0 2E5PA@1|root,330E0@2|Bacteria,1PJRE@1224|Proteobacteria,2W851@28216|Betaproteobacteria,2KNYY@206350|Nitrosomonadales 206350|Nitrosomonadales - - - - - - - - - - - - - - - HSJS3_k127_1356601_36 1122182.KB903833_gene5439 1.22e-15 87.0 COG2388@1|root,COG2388@2|Bacteria,2GQNP@201174|Actinobacteria,4DG05@85008|Micromonosporales 201174|Actinobacteria S Acetyltransferase - - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG HSJS3_k127_1356601_34 1047013.AQSP01000128_gene421 1.855e-17 92.0 COG0671@1|root,COG0671@2|Bacteria,2NPZH@2323|unclassified Bacteria 2|Bacteria I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - DUF3703,PAP2 HSJS3_k127_1356601_12 861299.J421_0859 3.42e-114 380.0 COG0346@1|root,COG0346@2|Bacteria,1ZTUT@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K15975 - - - - ko00000 - - - Glyoxalase HSJS3_k127_1356601_19 518766.Rmar_0269 1.211e-66 237.0 COG2391@1|root,COG2391@2|Bacteria,4NM6E@976|Bacteroidetes,1FK1T@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp HSJS3_k127_1356601_25 518766.Rmar_0268 2.988e-44 175.0 COG2391@1|root,COG2391@2|Bacteria,4NQ9C@976|Bacteroidetes,1FK4G@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp HSJS3_k127_1356601_42 743722.Sph21_3529 2.886e-06 57.0 COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,1IRZW@117747|Sphingobacteriia 976|Bacteroidetes C PFAM Cytochrome c, class I ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N HSJS3_k127_1356601_31 460265.Mnod_3274 5.033e-20 99.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,1JTMF@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - Cytochrome_CBB3,GSDH HSJS3_k127_1356601_4 1121930.AQXG01000016_gene1796 6.326e-189 602.0 COG2234@1|root,COG2234@2|Bacteria,4NENF@976|Bacteroidetes,1IPRF@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28,fn3 HSJS3_k127_1356601_43 1120948.KB903219_gene741 1.233e-05 58.0 COG1287@1|root,COG1287@2|Bacteria,2GMZM@201174|Actinobacteria,4E0ZH@85010|Pseudonocardiales 201174|Actinobacteria S oligosaccharyl transferase activity - - - - - - - - - - - - - HSJS3_k127_1356601_20 1005048.CFU_1946 6.236e-60 222.0 COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,2VP98@28216|Betaproteobacteria,473TB@75682|Oxalobacteraceae 28216|Betaproteobacteria S Winged helix DNA-binding domain ycaQ - - ko:K09927 - - - - ko00000 - - - HTH_42 HSJS3_k127_1356601_48 530564.Psta_4147 0.0004078 55.0 COG1310@1|root,COG1310@2|Bacteria 2|Bacteria S proteolysis - - - ko:K03665 - - - - ko00000,ko03009 - - - JAB,Prok-JAB HSJS3_k127_1356601_40 317936.Nos7107_1630 8.733e-07 61.0 COG0666@1|root,COG0666@2|Bacteria 2|Bacteria G response to abiotic stimulus - - - - - - - - - - - - Ank,Ank_2,Cu_amine_oxidN1 HSJS3_k127_1356601_22 56780.SYN_01692 3.972e-48 182.0 COG0204@1|root,COG0204@2|Bacteria,1P3XM@1224|Proteobacteria 1224|Proteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase HSJS3_k127_1356601_30 889378.Spiaf_2287 1.825e-23 102.0 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding HSJS3_k127_1356601_6 56780.SYN_01694 8.992e-170 544.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MQ97@213462|Syntrophobacterales 28221|Deltaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt HSJS3_k127_1356601_23 889378.Spiaf_2285 1.436e-46 179.0 COG0764@1|root,COG0764@2|Bacteria 2|Bacteria I 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA HSJS3_k127_1356601_16 889378.Spiaf_2284 6.19e-72 257.0 COG0764@1|root,COG0764@2|Bacteria 2|Bacteria I 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity fabA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090 FabA HSJS3_k127_1356601_11 391625.PPSIR1_07757 2.308e-114 388.0 COG0332@1|root,COG0332@2|Bacteria,1RB9M@1224|Proteobacteria,42YNV@68525|delta/epsilon subdivisions,2WTQM@28221|Deltaproteobacteria,2YYYC@29|Myxococcales 28221|Deltaproteobacteria I 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C HSJS3_k127_1356601_13 439235.Dalk_1753 2.629e-108 359.0 COG0300@1|root,COG0623@1|root,COG0300@2|Bacteria,COG0623@2|Bacteria,1R090@1224|Proteobacteria,43CRU@68525|delta/epsilon subdivisions,2X7ZF@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 HSJS3_k127_1356601_2 1121918.ARWE01000001_gene3150 4.196e-237 751.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans HSJS3_k127_1356601_28 1276920.ADIAG_02519 1.136e-30 128.0 COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,1W91W@1268|Micrococcaceae 201174|Actinobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase HSJS3_k127_1356601_1 384765.SIAM614_22982 2.84e-248 777.0 COG0069@1|root,COG4638@1|root,COG0069@2|Bacteria,COG4638@2|Bacteria,1MU7B@1224|Proteobacteria,2TRWC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase,Rieske,zf-CDGSH HSJS3_k127_1356601_3 518766.Rmar_1178 1.617e-210 676.0 COG3591@1|root,COG3591@2|Bacteria,4NEAK@976|Bacteroidetes,1FJT8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase S46 dpp7 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 HSJS3_k127_1356601_14 1158762.KB898038_gene1978 4.698e-95 326.0 COG1914@1|root,COG1914@2|Bacteria,1MWET@1224|Proteobacteria,1RY2N@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Mn2 and Fe2 transporters of the NRAMP family Z012_09610 - - - - - - - - - - - Nramp HSJS3_k127_1356601_9 1192034.CAP_7003 8.377e-137 449.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Cys Met metabolism - - 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP HSJS3_k127_1356601_8 880073.Calab_2785 6.443e-142 473.0 COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria 2|Bacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 HSJS3_k127_1356601_17 309807.SRU_0542 1.582e-71 251.0 COG0115@1|root,COG0115@2|Bacteria,4NI83@976|Bacteroidetes 976|Bacteroidetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 HSJS3_k127_1356601_37 1121434.AULY01000009_gene2038 1.6e-10 74.0 COG4961@1|root,COG4961@2|Bacteria,1NIG7@1224|Proteobacteria,42X7K@68525|delta/epsilon subdivisions,2WSKV@28221|Deltaproteobacteria,2M9N1@213115|Desulfovibrionales 28221|Deltaproteobacteria U Putative Flp pilus-assembly TadE/G-like - - - - - - - - - - - - Tad HSJS3_k127_1356601_10 686340.Metal_3071 1.413e-125 410.0 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,1RQD8@1236|Gammaproteobacteria,1XEPQ@135618|Methylococcales 135618|Methylococcales GM Male sterility protein - - - - - - - - - - - - Epimerase HSJS3_k127_1356601_5 502025.Hoch_4261 2.059e-180 575.0 COG1288@1|root,COG1288@2|Bacteria,1MY1J@1224|Proteobacteria 1224|Proteobacteria S C4-dicarboxylate anaerobic - - - - - - - - - - - - DcuC HSJS3_k127_1356601_46 106648.BBLJ01000004_gene1727 5.815e-05 53.0 COG0810@1|root,COG0810@2|Bacteria,1RJI3@1224|Proteobacteria,1SA6H@1236|Gammaproteobacteria,3NKNB@468|Moraxellaceae 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C HSJS3_k127_1356601_47 595460.RRSWK_05813 9.655e-05 52.0 COG3809@1|root,COG3809@2|Bacteria 2|Bacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - zf-TFIIB HSJS3_k127_1356601_26 861299.J421_1645 8.423e-36 143.0 2A4CF@1|root,30SY3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Yip1 HSJS3_k127_1356601_38 1121904.ARBP01000005_gene4616 4.585e-09 63.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity - - - - - - - - - - - - CMD HSJS3_k127_1356601_32 243230.DR_1765 7.797e-20 92.0 COG2128@1|root,COG2128@2|Bacteria,1WJIC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD HSJS3_k127_1356601_0 479434.Sthe_2058 3.706e-278 882.0 COG0567@1|root,COG0567@2|Bacteria,2G638@200795|Chloroflexi,27XYT@189775|Thermomicrobia 189775|Thermomicrobia C 2-oxoglutarate dehydrogenase N-terminus - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr HSJS3_k127_1356601_21 861299.J421_3626 8.249e-54 207.0 COG5557@1|root,COG5557@2|Bacteria,1ZTCE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pfam Polysulphide reductase, NrfD - - - - - - - - - - - - - HSJS3_k127_1356601_29 861299.J421_3627 7.65e-24 108.0 COG2010@1|root,COG2010@2|Bacteria,1ZTPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 HSJS3_k127_1356601_35 1379270.AUXF01000003_gene3824 5.874e-16 85.0 COG2010@1|root,COG2010@2|Bacteria,1ZTMS@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF3341) - - - - - - - - - - - - DUF3341 HSJS3_k127_1356601_7 1379698.RBG1_1C00001G1304 5.975e-162 521.0 COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria 2|Bacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD HSJS3_k127_1377439_20 1049564.TevJSym_aq00690 2.213e-32 133.0 COG4659@1|root,COG4659@2|Bacteria,1REZV@1224|Proteobacteria,1T054@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport - - - - - - - - - - - - FMN_bind HSJS3_k127_1377439_13 1049564.TevJSym_aq00680 3.635e-70 245.0 COG4660@1|root,COG4660@2|Bacteria,1R342@1224|Proteobacteria,1T62W@1236|Gammaproteobacteria,1JBVX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfE2 - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr HSJS3_k127_1377439_12 1049564.TevJSym_aq00670 9.495e-74 260.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr HSJS3_k127_1377439_15 290397.Adeh_1571 2.812e-46 181.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2YV2N@29|Myxococcales 28221|Deltaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE,MFS_1 HSJS3_k127_1377439_9 1379270.AUXF01000002_gene1600 9.241e-94 323.0 COG0515@1|root,COG0515@2|Bacteria 1379270.AUXF01000002_gene1600|- KLT protein kinase activity - - - - - - - - - - - - - HSJS3_k127_1377439_10 1248232.BANQ01000032_gene3817 3.618e-92 313.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XVNX@135623|Vibrionales 135623|Vibrionales M Small-conductance mechanosensitive channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel HSJS3_k127_1377439_11 525373.HMPREF0766_12742 7.436e-81 285.0 COG2866@1|root,COG2866@2|Bacteria,4NDXH@976|Bacteroidetes,1IQCS@117747|Sphingobacteriia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 HSJS3_k127_1377439_24 526225.Gobs_3887 2.059e-07 61.0 COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria 201174|Actinobacteria K histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 HSJS3_k127_1377439_14 234267.Acid_3868 4.241e-54 196.0 COG0053@1|root,COG0053@2|Bacteria,3Y5VF@57723|Acidobacteria 57723|Acidobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux HSJS3_k127_1377439_6 309807.SRU_2333 1.384e-120 398.0 COG1804@1|root,COG1804@2|Bacteria,4NEA8@976|Bacteroidetes,1FK8Y@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 HSJS3_k127_1377439_19 926550.CLDAP_22280 6.912e-36 138.0 COG3019@1|root,COG3019@2|Bacteria 2|Bacteria S metal-binding protein copG - - - - - - - - - - - DUF411 HSJS3_k127_1377439_2 1121930.AQXG01000001_gene1298 1.94e-201 657.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia 976|Bacteroidetes S cellulase activity - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_1377439_18 926560.KE387027_gene345 4.891e-40 169.0 COG3291@1|root,COG3291@2|Bacteria,1WKMB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus N Leishmanolysin - - - - - - - - - - - - PKD,Peptidase_M8 HSJS3_k127_1377439_21 861299.J421_3820 4.371e-19 102.0 COG1404@1|root,COG1404@2|Bacteria,1ZV5J@142182|Gemmatimonadetes 2|Bacteria O Subtilase family - - - ko:K14645 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Inhibitor_I9,PKD,Peptidase_S8,TIG HSJS3_k127_1377439_16 1156919.QWC_26283 5.631e-44 171.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria,3T8VD@506|Alcaligenaceae 28216|Betaproteobacteria M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel HSJS3_k127_1377439_0 1379270.AUXF01000001_gene2683 8.842e-243 764.0 COG0008@1|root,COG0008@2|Bacteria,1ZTAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C HSJS3_k127_1377439_17 1144275.COCOR_00285 3.067e-43 170.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42S9C@68525|delta/epsilon subdivisions,2WM4G@28221|Deltaproteobacteria,2YU8Y@29|Myxococcales 28221|Deltaproteobacteria Q Dienelactone hydrolase family dlhH2 - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH HSJS3_k127_1377439_1 1238182.C882_1234 1.394e-241 763.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2JSY5@204441|Rhodospirillales 204441|Rhodospirillales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N HSJS3_k127_1377439_5 391625.PPSIR1_27763 3.091e-127 428.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2YZ1X@29|Myxococcales 28221|Deltaproteobacteria C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C HSJS3_k127_1377439_7 404589.Anae109_3037 5.59e-113 379.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,42M3J@68525|delta/epsilon subdivisions,2WJZA@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF HSJS3_k127_1377439_8 1121405.dsmv_0256 3.038e-100 338.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,2MI58@213118|Desulfobacterales 28221|Deltaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport HSJS3_k127_1377439_3 555779.Dthio_PD2814 1.261e-175 557.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2M98D@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC HSJS3_k127_1377439_23 1248232.BANQ01000029_gene3948 6.83e-09 68.0 COG3187@1|root,COG4461@1|root,COG3187@2|Bacteria,COG4461@2|Bacteria,1PF0Q@1224|Proteobacteria,1TBDV@1236|Gammaproteobacteria,1XWBZ@135623|Vibrionales 135623|Vibrionales O META domain - - - - - - - - - - - - META HSJS3_k127_1377439_4 1283287.KB822577_gene3313 5.154e-145 469.0 COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4DPPU@85009|Propionibacteriales 201174|Actinobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N HSJS3_k127_14558_1 1499967.BAYZ01000078_gene967 3.131e-37 147.0 COG1487@1|root,COG1487@2|Bacteria 2|Bacteria S nuclease activity - - - ko:K18828 - - - - ko00000,ko01000,ko02048,ko03016 - - - PIN HSJS3_k127_14558_0 566466.NOR53_3413 4.501e-67 239.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_149386_20 926560.KE387027_gene303 1.829e-42 166.0 COG1917@1|root,COG1917@2|Bacteria,1WMIY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - HSJS3_k127_149386_22 483219.LILAB_35130 1.01e-41 158.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,42SI7@68525|delta/epsilon subdivisions,2WPSJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the UPF0178 family yaiI - - ko:K09768 - - - - ko00000 - - - DUF188 HSJS3_k127_149386_10 1163617.SCD_n02227 3.941e-83 287.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,2WGKB@28216|Betaproteobacteria 28216|Betaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel HSJS3_k127_149386_17 1047013.AQSP01000107_gene2087 2.412e-48 184.0 COG0668@1|root,COG0668@2|Bacteria,2NPVN@2323|unclassified Bacteria 2|Bacteria M Mechanosensitive ion channel mscS_1 - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - BON,MS_channel HSJS3_k127_149386_9 382464.ABSI01000012_gene2201 2.334e-84 304.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C HSJS3_k127_149386_18 861299.J421_2925 2.616e-46 173.0 COG1666@1|root,COG1666@2|Bacteria,1ZTNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF520) - - - ko:K09767 - - - - ko00000 - - - DUF520 HSJS3_k127_149386_25 1217718.ALOU01000005_gene1522 1.672e-32 145.0 COG3629@1|root,COG3899@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,1KCSE@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD HSJS3_k127_149386_12 861299.J421_0867 7.348e-78 293.0 COG0515@1|root,COG0515@2|Bacteria 861299.J421_0867|- KLT protein kinase activity - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - HSJS3_k127_149386_23 1379270.AUXF01000005_gene516 8.31e-35 142.0 COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 HSJS3_k127_149386_13 234267.Acid_5451 1.161e-61 225.0 COG0451@1|root,COG0451@2|Bacteria,3Y93E@57723|Acidobacteria 57723|Acidobacteria M PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase HSJS3_k127_149386_35 1236494.BAJN01000015_gene1868 3.789e-12 78.0 COG0671@1|root,COG0671@2|Bacteria,4NMKG@976|Bacteroidetes,2FM8J@200643|Bacteroidia 976|Bacteroidetes I Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - PAP2_3 HSJS3_k127_149386_14 1313301.AUGC01000003_gene2121 5.174e-60 219.0 COG0451@1|root,COG0451@2|Bacteria,4NEMN@976|Bacteroidetes 976|Bacteroidetes M NAD dependent epimerase dehydratase family dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase HSJS3_k127_149386_31 518766.Rmar_2569 2.403e-15 85.0 COG1266@1|root,COG1266@2|Bacteria,4PEJM@976|Bacteroidetes,1FJ86@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S CAAX protease self-immunity - - - - - - - - - - - - - HSJS3_k127_149386_4 595460.RRSWK_05252 4.161e-120 398.0 COG3174@1|root,COG3174@2|Bacteria,2J41N@203682|Planctomycetes 203682|Planctomycetes S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC HSJS3_k127_149386_33 1088721.NSU_3076 1.252e-13 76.0 2ABDW@1|root,310UP@2|Bacteria,1REJY@1224|Proteobacteria,2UIU1@28211|Alphaproteobacteria,2K8AE@204457|Sphingomonadales 204457|Sphingomonadales S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like HSJS3_k127_149386_7 1123054.KB907717_gene212 1.093e-98 331.0 COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,1T1UP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short HSJS3_k127_149386_42 1286632.P278_32260 0.0006993 48.0 2BIB7@1|root,32CGZ@2|Bacteria,4NQKQ@976|Bacteroidetes,1I2T7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_149386_37 946077.W5A_02195 2.707e-10 67.0 2BIB7@1|root,32CGZ@2|Bacteria,4NQKQ@976|Bacteroidetes,1I2T7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_149386_6 1385935.N836_31105 1.693e-104 357.0 COG0438@1|root,COG0438@2|Bacteria,1GA3S@1117|Cyanobacteria,1HH3K@1150|Oscillatoriales 1117|Cyanobacteria M Glycosyl transferases group 1 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2 HSJS3_k127_149386_24 1454004.AW11_02148 4.825e-34 152.0 COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,2VUX2@28216|Betaproteobacteria 28216|Betaproteobacteria M glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_transf_7C,Glycos_transf_2,PIG-L HSJS3_k127_149386_29 690850.Desaf_0645 1.969e-21 111.0 COG0438@1|root,COG0438@2|Bacteria,1PVZ8@1224|Proteobacteria,42TY9@68525|delta/epsilon subdivisions,2WQH3@28221|Deltaproteobacteria,2MCWW@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 HSJS3_k127_149386_8 861299.J421_6071 9.218e-91 313.0 COG1134@1|root,COG1134@2|Bacteria 2|Bacteria GM teichoic acid transport - - 3.6.3.38 ko:K01990,ko:K09689,ko:K09691 ko02010,map02010 M00249,M00250,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.101,3.A.1.103 - - ABC_tran,Wzt_C HSJS3_k127_149386_11 861299.J421_6070 2.824e-80 277.0 COG1682@1|root,COG1682@2|Bacteria 2|Bacteria GM macromolecule localization - - - ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 - - ABC2_membrane HSJS3_k127_149386_38 102129.Lepto7375DRAFT_2340 4.052e-10 73.0 COG5305@1|root,COG5305@2|Bacteria,1GC59@1117|Cyanobacteria 1117|Cyanobacteria S COGs COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family - - - - - - - - - - - - PMT_2 HSJS3_k127_149386_5 760192.Halhy_6009 1.569e-109 378.0 COG0520@1|root,COG0520@2|Bacteria,4NJEQ@976|Bacteroidetes,1IW66@117747|Sphingobacteriia 976|Bacteroidetes E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 HSJS3_k127_149386_32 861299.J421_6042 5.225e-15 76.0 2EGPU@1|root,31UHV@2|Bacteria,1ZV7H@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_149386_30 861299.J421_6043 1.167e-18 91.0 2AUAW@1|root,31JYI@2|Bacteria,1ZV7R@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_149386_0 861299.J421_6044 4.454e-290 902.0 COG2192@1|root,COG2192@2|Bacteria,1ZUTI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Carbamoyltransferase C-terminus - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N HSJS3_k127_149386_2 575540.Isop_3122 1.203e-141 460.0 COG0463@1|root,COG0463@2|Bacteria,2J2HF@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 HSJS3_k127_149386_36 1128421.JAGA01000002_gene1356 5.03e-12 79.0 COG1807@1|root,COG1807@2|Bacteria 1128421.JAGA01000002_gene1356|- M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - - HSJS3_k127_149386_28 575540.Isop_2254 1.464e-21 111.0 COG1807@1|root,COG1807@2|Bacteria,2J2PY@203682|Planctomycetes 203682|Planctomycetes M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - HSJS3_k127_149386_39 56780.SYN_01247 2.94e-06 52.0 2DCXT@1|root,2ZFR8@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_149386_19 926560.KE387027_gene964 1.262e-43 166.0 COG5516@1|root,COG5516@2|Bacteria,1WMR5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Putative stress-induced transcription regulator - - - - - - - - - - - - ABATE,zf-CGNR HSJS3_k127_149386_16 1121378.KB899771_gene644 6.835e-52 195.0 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination ydzE - - - - - - - - - - - EamA HSJS3_k127_149386_3 243231.GSU0914 8.892e-127 418.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,43T9G@69541|Desulfuromonadales 28221|Deltaproteobacteria L helicase superfamily c-terminal domain rhlE-2 - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C HSJS3_k127_149386_27 1157943.KB892705_gene2373 3.782e-26 121.0 COG0438@1|root,COG0438@2|Bacteria,2GKEA@201174|Actinobacteria,232NK@1762|Mycobacteriaceae 201174|Actinobacteria M Glycosyl transferase 4-like domain - - - ko:K21011 ko02025,map02025 - - - ko00000,ko00001,ko01003 - GT4 - DUF3492,Glyco_trans_1_4,Glycos_transf_1 HSJS3_k127_149386_15 1125863.JAFN01000001_gene3410 8.948e-56 211.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD HSJS3_k127_149386_1 1089550.ATTH01000001_gene1477 1.797e-183 604.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1FIMC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S repeat protein - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_149386_26 1121033.AUCF01000011_gene1708 7.002e-31 130.0 COG0438@1|root,COG0457@1|root,COG0463@1|root,COG1215@1|root,COG3774@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0463@2|Bacteria,COG1215@2|Bacteria,COG3774@2|Bacteria,1RF3D@1224|Proteobacteria,2U86H@28211|Alphaproteobacteria,2JX6Z@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 HSJS3_k127_149386_43 351160.RCIX1942 0.0007738 51.0 arCOG02521@1|root,arCOG02521@2157|Archaea,2Y7UY@28890|Euryarchaeota,2NBMU@224756|Methanomicrobia 2157|Archaea S Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Glyco_hydro_28,NosD,Pectate_lyase_3 HSJS3_k127_149386_41 1082931.KKY_2436 3.375e-05 50.0 2EFVW@1|root,339N3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_149386_21 497321.C664_13674 1.982e-42 158.0 2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,2KX0T@206389|Rhodocyclales 206389|Rhodocyclales S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 HSJS3_k127_149386_34 1122604.JONR01000004_gene853 2.542e-12 77.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - HSJS3_k127_1585403_35 688270.Celal_3761 8.723e-09 68.0 COG5492@1|root,COG5492@2|Bacteria,4NT99@976|Bacteroidetes,1I25B@117743|Flavobacteriia 976|Bacteroidetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Alpha-amylase,Beta_helix,Big_2,CBM26,CBM9_1,DM13,DUF4979,Pectate_lyase_3 HSJS3_k127_1585403_27 665571.STHERM_c11010 2.109e-27 129.0 COG0801@1|root,COG0801@2|Bacteria,2J8EN@203691|Spirochaetes 203691|Spirochaetes H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK HSJS3_k127_1585403_21 379066.GAU_2350 3.759e-54 212.0 COG2856@1|root,COG2856@2|Bacteria,1ZSXU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zn peptidase - - - - - - - - - - - - - HSJS3_k127_1585403_17 338966.Ppro_2027 3.528e-82 287.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,43TT5@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI HSJS3_k127_1585403_7 861299.J421_2604 1.709e-130 443.0 COG0318@1|root,COG0318@2|Bacteria,1ZSXP@142182|Gemmatimonadetes 142182|Gemmatimonadetes IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C HSJS3_k127_1585403_12 1379270.AUXF01000004_gene3227 2.845e-98 344.0 COG1432@1|root,COG1432@2|Bacteria,1ZSRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH HSJS3_k127_1585403_23 518766.Rmar_1529 1.881e-48 180.0 COG2094@1|root,COG2094@2|Bacteria,4NP22@976|Bacteroidetes,1FJ9P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L Belongs to the DNA glycosylase MPG family mpg - 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco HSJS3_k127_1585403_20 1297742.A176_01664 2.582e-61 226.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YW82@29|Myxococcales 28221|Deltaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 HSJS3_k127_1585403_5 247634.GPB2148_828 1.127e-143 469.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1RP6I@1236|Gammaproteobacteria,1J53V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C4-dicarboxylate anaerobic carrier mleN - - - - - - - - - - - Na_H_antiporter HSJS3_k127_1585403_14 309807.SRU_1894 3.567e-90 321.0 COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,1FJEG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase family M1 domain - - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,Peptidase_M1 HSJS3_k127_1585403_24 1089550.ATTH01000001_gene1580 2.571e-44 170.0 COG0720@1|root,COG0720@2|Bacteria,4NNY0@976|Bacteroidetes,1FJAI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS HSJS3_k127_1585403_19 861299.J421_2704 5.942e-69 247.0 COG0302@1|root,COG0302@2|Bacteria,1ZT6I@142182|Gemmatimonadetes 142182|Gemmatimonadetes H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI HSJS3_k127_1585403_38 1198232.CYCME_1453 0.0003476 48.0 COG1232@1|root,COG1232@2|Bacteria,1QX3T@1224|Proteobacteria,1T3RT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase HSJS3_k127_1585403_26 861299.J421_2711 4.656e-31 128.0 COG0457@1|root,COG0457@2|Bacteria,1ZTX0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 HSJS3_k127_1585403_3 1379270.AUXF01000004_gene3094 4.41e-149 494.0 COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes 142182|Gemmatimonadetes I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding HSJS3_k127_1585403_31 404589.Anae109_1180 1.148e-24 108.0 COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2Z0IS@29|Myxococcales 28221|Deltaproteobacteria P CutA1 divalent ion tolerance protein cutA - - ko:K03926 - - - - ko00000 - - - CutA1 HSJS3_k127_1585403_33 231434.JQJH01000001_gene1729 2.689e-18 94.0 COG0457@1|root,COG2227@1|root,COG3914@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3NAKJ@45404|Beijerinckiaceae 28211|Alphaproteobacteria HO Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 HSJS3_k127_1585403_28 1121918.ARWE01000001_gene3484 2.205e-27 129.0 COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,42Q2W@68525|delta/epsilon subdivisions,2WJIA@28221|Deltaproteobacteria,43S0C@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 HSJS3_k127_1585403_10 1279009.ADICEAN_04061 3.907e-101 356.0 COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,47KI1@768503|Cytophagia 976|Bacteroidetes C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - - - - - - - - - - SDF HSJS3_k127_1585403_8 861299.J421_3942 2.21e-104 348.0 COG1208@1|root,COG1208@2|Bacteria,1ZSYR@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase HSJS3_k127_1585403_6 1192034.CAP_5366 3.361e-137 448.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales 28221|Deltaproteobacteria E synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like HSJS3_k127_1585403_30 1158050.KB895460_gene3077 4.965e-26 123.0 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,1W944@1268|Micrococcaceae 201174|Actinobacteria C Glycerophosphoryl diester phosphodiesterase family glpQ2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD HSJS3_k127_1585403_4 861299.J421_3937 1.154e-144 465.0 COG0473@1|root,COG0473@2|Bacteria,1ZTDX@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh HSJS3_k127_1585403_2 861299.J421_3934 2.475e-185 586.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N HSJS3_k127_1585403_29 886293.Sinac_1934 1.734e-26 120.0 COG1657@1|root,COG1657@2|Bacteria,2J0IG@203682|Planctomycetes 203682|Planctomycetes I PFAM Prenyltransferase squalene oxidase - - - - - - - - - - - - - HSJS3_k127_1585403_16 644968.DFW101_3399 1.889e-87 300.0 COG2006@1|root,COG2006@2|Bacteria,1R7BH@1224|Proteobacteria,42QGJ@68525|delta/epsilon subdivisions,2WJ1A@28221|Deltaproteobacteria,2MAYQ@213115|Desulfovibrionales 28221|Deltaproteobacteria S Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 HSJS3_k127_1585403_13 344747.PM8797T_04345 6.529e-97 328.0 COG1446@1|root,COG1446@2|Bacteria,2IZ4V@203682|Planctomycetes 203682|Planctomycetes E PFAM peptidase T2 asparaginase 2 - - 3.4.19.5,3.5.1.26 ko:K01444,ko:K13051 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2,DUF4440 HSJS3_k127_1585403_1 91464.S7335_1929 1.892e-190 604.0 COG0422@1|root,COG0422@2|Bacteria,1G2N9@1117|Cyanobacteria,1GYR0@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM HSJS3_k127_1585403_25 1237149.C900_00535 2.603e-34 144.0 2CIH2@1|root,2ZTG0@2|Bacteria,4NNM2@976|Bacteroidetes,47VGE@768503|Cytophagia 976|Bacteroidetes S Putative lumazine-binding - - - - - - - - - - - - Lumazine_bd_2 HSJS3_k127_1585403_22 760011.Spico_1294 5.874e-52 190.0 COG0634@1|root,COG0634@2|Bacteria,2J8PE@203691|Spirochaetes 203691|Spirochaetes F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran HSJS3_k127_1585403_9 388413.ALPR1_00680 2.465e-103 348.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cu_amine_oxidN1,Phytase-like HSJS3_k127_1585403_34 345341.KUTG_04140 1.136e-14 79.0 2DTR4@1|root,33MCB@2|Bacteria,2HAJT@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - HSJS3_k127_1585403_11 1191523.MROS_1496 6.242e-101 345.0 COG0612@1|root,COG0612@2|Bacteria 2|Bacteria L Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C HSJS3_k127_1585403_18 29581.BW37_00307 1.043e-71 259.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2VHVB@28216|Betaproteobacteria,472VG@75682|Oxalobacteraceae 28216|Betaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C HSJS3_k127_1585403_15 861299.J421_0907 1.471e-87 295.0 COG1595@1|root,COG1595@2|Bacteria,1ZT2V@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_1585403_37 1121428.DESHY_40085___1 3.731e-06 56.0 COG5662@1|root,COG5662@2|Bacteria,1U216@1239|Firmicutes,25N56@186801|Clostridia,2631J@186807|Peptococcaceae 186801|Clostridia K Domain of unknown function (DUF4349) - - - - - - - - - - - - DUF4349,zf-HC2 HSJS3_k127_1585403_32 1379270.AUXF01000002_gene1166 2.266e-24 115.0 COG1466@1|root,COG1466@2|Bacteria,1ZSSZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta HSJS3_k127_1585403_0 861299.J421_0903 2.059e-237 769.0 COG0249@1|root,COG0249@2|Bacteria,1ZST5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V HSJS3_k127_1753464_0 861299.J421_3142 3.415e-144 463.0 COG0540@1|root,COG0540@2|Bacteria,1ZSN7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N HSJS3_k127_1753464_6 861299.J421_3141 2.878e-47 177.0 COG2065@1|root,COG2065@2|Bacteria,1ZTHG@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran HSJS3_k127_1753464_1 518766.Rmar_1647 4.643e-143 484.0 COG1757@1|root,COG1757@2|Bacteria,4NHP9@976|Bacteroidetes,1FIXG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Na H antiporter - - - - - - - - - - - - Na_H_antiporter HSJS3_k127_1753464_5 1029824.AFID01000003_gene301 8.722e-48 180.0 COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,1W96T@1268|Micrococcaceae 201174|Actinobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.1,3.5.4.33 ko:K01485,ko:K11991 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922,R10223 RC00074,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 HSJS3_k127_1753464_2 1379270.AUXF01000005_gene572 4.028e-133 443.0 COG0008@1|root,COG0008@2|Bacteria,1ZSSX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c HSJS3_k127_1753464_3 1123261.AXDW01000008_gene951 2.742e-127 422.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,1X3P8@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - - - - - - - - - - - Thiolase_C,Thiolase_N HSJS3_k127_1753464_7 309801.trd_A0395 4.48e-41 164.0 COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi,27XHZ@189775|Thermomicrobia 189775|Thermomicrobia O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - COX15-CtaA,UbiA HSJS3_k127_1753464_4 861299.J421_4174 1.381e-124 414.0 COG1132@1|root,COG1132@2|Bacteria,1ZSP1@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran HSJS3_k127_1907767_6 1121930.AQXG01000001_gene1299 2.298e-91 311.0 COG3391@1|root,COG3391@2|Bacteria,4PJH2@976|Bacteroidetes,1IZRD@117747|Sphingobacteriia 976|Bacteroidetes S Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase HSJS3_k127_1907767_2 1121930.AQXG01000001_gene1300 5.51e-186 601.0 COG2931@1|root,COG2931@2|Bacteria,4NFV5@976|Bacteroidetes,1IYME@117747|Sphingobacteriia 976|Bacteroidetes Q Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - - - - - - - - - - VCBS HSJS3_k127_1907767_25 1384056.N787_08245 1.427e-05 56.0 COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1X57Z@135614|Xanthomonadales 135614|Xanthomonadales M salt-induced outer membrane protein - - - ko:K07283 - - - - ko00000 - - - DUF481 HSJS3_k127_1907767_19 1122612.AUBA01000015_gene952 9.007e-21 107.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1N7YB@1224|Proteobacteria,2V7CZ@28211|Alphaproteobacteria,2K2SU@204457|Sphingomonadales 204457|Sphingomonadales S TIR domain - - - - - - - - - - - - TIR_2 HSJS3_k127_1907767_23 1322246.BN4_10833 5.003e-07 58.0 2AHEE@1|root,317RI@2|Bacteria,1PZ46@1224|Proteobacteria,435PX@68525|delta/epsilon subdivisions,2X03X@28221|Deltaproteobacteria,2MAC9@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_1907767_17 32057.KB217478_gene7233 1.567e-25 113.0 COG0580@1|root,COG0580@2|Bacteria 2|Bacteria U water channel activity glpF - - ko:K02440,ko:K06188 - - - - ko00000,ko02000 1.A.8,1.A.8.1,1.A.8.2 - - MIP HSJS3_k127_1907767_3 1121930.AQXG01000011_gene1720 8.088e-168 552.0 COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes 976|Bacteroidetes Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 HSJS3_k127_1907767_5 666685.R2APBS1_2311 2.944e-120 407.0 COG1228@1|root,COG1228@2|Bacteria,1R6NP@1224|Proteobacteria,1SZBD@1236|Gammaproteobacteria,1X5QW@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 HSJS3_k127_1907767_13 879243.Poras_0538 2.915e-41 162.0 COG0847@1|root,COG0847@2|Bacteria,4NE82@976|Bacteroidetes,2FMQF@200643|Bacteroidia,22WYR@171551|Porphyromonadaceae 976|Bacteroidetes L DNA polymerase III subunit epsilon dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T HSJS3_k127_1907767_11 991905.SL003B_3221 5.325e-54 195.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,4BQMS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL HSJS3_k127_1907767_0 309807.SRU_0349 5.15e-275 874.0 COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes 976|Bacteroidetes O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 HSJS3_k127_1907767_9 1144275.COCOR_02487 3.303e-66 241.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Thioredoxin - - - - - - - - - - - - SurA_N_3,Thioredoxin_4 HSJS3_k127_1907767_14 1519464.HY22_13125 8.563e-38 159.0 COG0737@1|root,COG1520@1|root,COG0737@2|Bacteria,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - 3.4.17.18 ko:K05996 - - - - ko00000,ko01000,ko01002 - - - 5_nucleotid_C,Cytochrome_C554,SBP_bac_8,SLH HSJS3_k127_1907767_16 1120936.KB907219_gene3235 2.126e-27 125.0 COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4EFRP@85012|Streptosporangiales 201174|Actinobacteria K WYL domain pafB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K13572,ko:K13573 - - - - ko00000,ko03051 - - - WYL HSJS3_k127_1907767_15 313589.JNB_02915 3.063e-28 130.0 COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4FEBU@85021|Intrasporangiaceae 201174|Actinobacteria K Proteasome accessory factor C pafC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K13573 - - - - ko00000,ko03051 - - - WYL HSJS3_k127_1907767_10 1348114.OM33_04140 6.861e-65 231.0 COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,1RYXR@1236|Gammaproteobacteria,2Q1G4@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S enzyme related to lactoylglutathione lyase - - - ko:K06996 - - - - ko00000 - - - Glyoxalase HSJS3_k127_1907767_21 593750.Metfor_1905 1.017e-16 96.0 arCOG00805@1|root,arCOG00805@2157|Archaea,2XVHZ@28890|Euryarchaeota 28890|Euryarchaeota L COG3857 ATP-dependent nuclease, subunit B - - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 HSJS3_k127_1907767_8 997346.HMPREF9374_1651 2.036e-70 272.0 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,4HA64@91061|Bacilli,27CSD@186824|Thermoactinomycetaceae 91061|Bacilli L PD-(D/E)XK nuclease superfamily - - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C HSJS3_k127_1907767_4 861299.J421_0330 3.867e-139 457.0 COG2355@1|root,COG2355@2|Bacteria,1ZT5A@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 HSJS3_k127_1907767_18 861299.J421_2050 1.9e-25 108.0 COG3695@1|root,COG3695@2|Bacteria 2|Bacteria L enzyme binding ogt - 2.1.1.63 ko:K00567,ko:K07443 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,YjbR HSJS3_k127_1907767_12 313606.M23134_01323 1.224e-42 162.0 COG1595@1|root,COG1595@2|Bacteria,4NQTP@976|Bacteroidetes,47QT5@768503|Cytophagia 976|Bacteroidetes K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_1907767_22 530564.Psta_2074 4.942e-16 85.0 COG4961@1|root,COG4961@2|Bacteria,2J0PV@203682|Planctomycetes 203682|Planctomycetes U TadE-like protein - - - - - - - - - - - - TadE HSJS3_k127_1907767_20 745718.JADT01000014_gene128 3.84e-19 92.0 2ETTP@1|root,33MB1@2|Bacteria,4NZFX@976|Bacteroidetes,1I6T5@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_1907767_7 316067.Geob_1840 1.219e-75 260.0 COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria,43U6T@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 HSJS3_k127_1907767_1 404589.Anae109_0939 3.142e-189 607.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales 28221|Deltaproteobacteria L ATP dependent DNA ligase domain protein - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N HSJS3_k127_1909422_9 479434.Sthe_0770 1.574e-110 363.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi,27Y4S@189775|Thermomicrobia 189775|Thermomicrobia G Belongs to the PEP-utilizing enzyme family - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N HSJS3_k127_1909422_0 880073.Calab_2344 4.292e-272 866.0 COG4772@1|root,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug HSJS3_k127_1909422_8 945713.IALB_2637 9.24e-131 427.0 COG0158@1|root,COG0158@2|Bacteria 2|Bacteria G fructose 1,6-bisphosphate 1-phosphatase activity fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - iUTI89_1310.UTI89_C4836,ic_1306.c5329 FBPase HSJS3_k127_1909422_4 929703.KE386491_gene4070 7.432e-168 546.0 COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,47K79@768503|Cytophagia 976|Bacteroidetes G PFAM Glycoside hydrolase, family 20, catalytic core - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b HSJS3_k127_1909422_18 880070.Cycma_2337 8.671e-41 162.0 COG1209@1|root,COG1209@2|Bacteria,4NF32@976|Bacteroidetes,47K6F@768503|Cytophagia 976|Bacteroidetes M Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase HSJS3_k127_1909422_1 1239962.C943_03388 4.256e-220 697.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,47MV2@768503|Cytophagia 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF HSJS3_k127_1909422_15 234267.Acid_6592 6.124e-62 234.0 COG0153@1|root,COG0153@2|Bacteria,3Y300@57723|Acidobacteria 2|Bacteria G Belongs to the GHMP kinase family. GalK subfamily - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg HSJS3_k127_1909422_5 861299.J421_2200 2.415e-144 471.0 COG0673@1|root,COG0673@2|Bacteria,1ZSRB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA HSJS3_k127_1909422_12 379066.GAU_1455 3.226e-72 271.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1ZSMY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Competence protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B HSJS3_k127_1909422_7 1379270.AUXF01000005_gene708 2.229e-142 466.0 COG0621@1|root,COG0621@2|Bacteria,1ZT0Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 HSJS3_k127_1909422_23 379066.GAU_1453 4.197e-11 75.0 2EYUI@1|root,33S1Q@2|Bacteria,1ZTHR@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_1909422_24 861299.J421_3096 5.95e-05 55.0 2F0K0@1|root,33TNP@2|Bacteria,1ZTJU@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_1909422_19 861299.J421_3095 1.018e-33 136.0 COG0295@1|root,COG0295@2|Bacteria,1ZTZY@142182|Gemmatimonadetes 142182|Gemmatimonadetes F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 HSJS3_k127_1909422_14 251221.35214391 2.108e-62 239.0 COG0787@1|root,COG0787@2|Bacteria,1G0IV@1117|Cyanobacteria 1117|Cyanobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N HSJS3_k127_1909422_13 1379270.AUXF01000005_gene702 2.507e-63 231.0 COG1694@1|root,COG3956@2|Bacteria,1ZSZH@142182|Gemmatimonadetes 142182|Gemmatimonadetes S MazG nucleotide pyrophosphohydrolase domain - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - MazG HSJS3_k127_1909422_21 861299.J421_4475 6.153e-13 75.0 2CA9X@1|root,2ZJY8@2|Bacteria,1ZU1S@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_1909422_2 379066.GAU_1447 9.396e-182 577.0 COG0017@1|root,COG0017@2|Bacteria,1ZSTX@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon HSJS3_k127_1909422_3 644966.Tmar_0929 5.837e-170 559.0 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WCF1@538999|Clostridiales incertae sedis 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge HSJS3_k127_1909422_20 1379270.AUXF01000005_gene697 8.8e-31 140.0 COG1572@1|root,COG1572@2|Bacteria,1ZSTW@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - HSJS3_k127_1909422_16 1379270.AUXF01000005_gene696 1.768e-59 222.0 COG0739@1|root,COG0739@2|Bacteria,1ZSUW@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 HSJS3_k127_1909422_6 861299.J421_3080 2.083e-143 469.0 COG0206@1|root,COG0206@2|Bacteria,1ZSNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin HSJS3_k127_1909422_10 1379270.AUXF01000005_gene693 3.32e-98 334.0 COG0849@1|root,COG0849@2|Bacteria,1ZSRE@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA HSJS3_k127_1909422_22 1379270.AUXF01000005_gene692 1.609e-11 76.0 COG1589@1|root,COG1589@2|Bacteria,1ZTRX@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cell division protein FtsQ - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - POTRA_1 HSJS3_k127_1909422_17 570952.ATVH01000014_gene2076 2.453e-51 193.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,2JPRS@204441|Rhodospirillales 204441|Rhodospirillales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C HSJS3_k127_1909422_11 1379270.AUXF01000005_gene691 1.951e-80 283.0 COG0773@1|root,COG0773@2|Bacteria,1ZSQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M HSJS3_k127_2074012_0 1122603.ATVI01000005_gene3502 2.413e-05 58.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 HSJS3_k127_2125209_17 1306174.JODP01000003_gene1909 4.354e-24 112.0 COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria 201174|Actinobacteria I Diacylglycerol kinase - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - DAGK_cat,PAP2 HSJS3_k127_2125209_23 987059.RBXJA2T_08093 1.192e-05 60.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2VJB8@28216|Betaproteobacteria,1KIV4@119065|unclassified Burkholderiales 28216|Betaproteobacteria S TamB, inner membrane protein subunit of TAM complex tamB - - ko:K09800 - - - - ko00000,ko02000 - - - TamB HSJS3_k127_2125209_7 861299.J421_2338 6.957e-90 327.0 COG4775@1|root,COG4775@2|Bacteria,1ZSY7@142182|Gemmatimonadetes 2|Bacteria M Surface antigen - - - ko:K07277,ko:K07278 - - - - ko00000,ko02000,ko03029 1.B.33,1.B.33.2.4 - - Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA HSJS3_k127_2125209_11 861299.J421_2559 7.535e-61 222.0 COG0682@1|root,COG0682@2|Bacteria,1ZSYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT HSJS3_k127_2125209_5 861299.J421_2560 7.781e-95 324.0 COG0533@1|root,COG0533@2|Bacteria,1ZT0P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 HSJS3_k127_2125209_21 370438.PTH_0537 9.723e-10 70.0 COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,2612S@186807|Peptococcaceae 186801|Clostridia S PFAM YbbR-like protein - - - - - - - - - - - - YbbR HSJS3_k127_2125209_19 390989.JOEG01000021_gene2675 2.087e-14 83.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D8KT@85008|Micromonosporales 201174|Actinobacteria KLT serine threonine protein kinase pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase HSJS3_k127_2125209_10 861299.J421_2565 1.663e-69 253.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1ZTGM@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB HSJS3_k127_2125209_4 234267.Acid_7731 1.909e-96 325.0 COG2022@1|root,COG2022@2|Bacteria 2|Bacteria H thiamine diphosphate biosynthetic process thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS HSJS3_k127_2125209_20 1452718.JBOY01000046_gene1044 1.318e-13 72.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria 1236|Gammaproteobacteria H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS HSJS3_k127_2125209_15 644966.Tmar_1855 1.507e-31 133.0 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,3WDBQ@538999|Clostridiales incertae sedis 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI HSJS3_k127_2125209_9 1167006.UWK_00824 1.228e-79 278.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2WKMK@28221|Deltaproteobacteria,2MI0Y@213118|Desulfobacterales 28221|Deltaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N HSJS3_k127_2125209_13 396595.TK90_2273 8.313e-42 160.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase HSJS3_k127_2125209_18 379066.GAU_0626 2.16e-19 91.0 COG1862@1|root,COG1862@2|Bacteria,1ZU5F@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Preprotein translocase subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC HSJS3_k127_2125209_2 861299.J421_2569 1.494e-128 429.0 COG0343@1|root,COG0343@2|Bacteria,1ZSRS@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) - - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT HSJS3_k127_2125209_3 861299.J421_2570 2.533e-115 383.0 COG0809@1|root,COG0809@2|Bacteria,1ZSV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth HSJS3_k127_2125209_1 379066.GAU_0629 7.159e-141 458.0 COG2255@1|root,COG2255@2|Bacteria,1ZT9W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N HSJS3_k127_2125209_16 748658.KB907313_gene2166 8.854e-29 127.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N HSJS3_k127_2125209_12 379066.GAU_0634 4.654e-46 171.0 COG0817@1|root,COG0817@2|Bacteria,1ZTKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC HSJS3_k127_2125209_8 880073.Calab_2588 1.464e-83 284.0 COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria 2|Bacteria K Transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg HSJS3_k127_2125209_0 1379698.RBG1_1C00001G0830 3.278e-202 650.0 COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria 2|Bacteria J elongation factor G fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 HSJS3_k127_2125209_14 1519464.HY22_01215 3.589e-39 160.0 COG0705@1|root,COG0705@2|Bacteria,1FDF1@1090|Chlorobi 1090|Chlorobi S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid HSJS3_k127_2125209_6 471852.Tcur_3455 1.521e-93 317.0 COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4EI19@85012|Streptosporangiales 201174|Actinobacteria M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N HSJS3_k127_2125209_22 402881.Plav_0184 2.674e-09 60.0 COG0810@1|root,COG0810@2|Bacteria,1NJ1R@1224|Proteobacteria,2UGFN@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C HSJS3_k127_2148488_7 519989.ECTPHS_08978 1.884e-90 313.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RQ04@1236|Gammaproteobacteria,1WXUZ@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE HSJS3_k127_2148488_3 555079.Toce_0698 5.905e-128 425.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales 186801|Clostridia C Part of a membrane complex involved in electron transport rnfC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,RnfC_N,SLBB HSJS3_k127_2148488_0 1379270.AUXF01000001_gene2161 0.0 1979.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C HSJS3_k127_2148488_8 382464.ABSI01000002_gene4375 1.212e-89 303.0 COG2878@1|root,COG2878@2|Bacteria 2|Bacteria C electron transfer activity rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4,Fer4_7 HSJS3_k127_2148488_5 1049564.TevJSym_bb00040 1.376e-97 331.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C HSJS3_k127_2148488_1 1049564.TevJSym_bb00050 1.411e-227 721.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N HSJS3_k127_2148488_23 521011.Mpal_0755 0.0006946 51.0 COG3391@1|root,arCOG03563@2157|Archaea 2157|Archaea P NHL repeat containing protein - - - - - - - - - - - - CBM_6,HemolysinCabind,NHL,PKD HSJS3_k127_2148488_9 313606.M23134_03563 1.39e-74 271.0 COG4099@1|root,COG4099@2|Bacteria,4NJFP@976|Bacteroidetes,47SYK@768503|Cytophagia 976|Bacteroidetes S phospholipase Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Esterase HSJS3_k127_2148488_15 395495.Lcho_2129 1.622e-46 181.0 COG0348@1|root,COG0633@1|root,COG1251@1|root,COG0348@2|Bacteria,COG0633@2|Bacteria,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,1KK4A@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Pyr_redox_2 HSJS3_k127_2148488_14 479434.Sthe_0472 3.857e-56 203.0 COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi,27YAF@189775|Thermomicrobia 189775|Thermomicrobia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII HSJS3_k127_2148488_16 292459.STH1471 4.887e-42 161.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 HSJS3_k127_2148488_6 379066.GAU_2332 1.656e-90 306.0 COG0336@1|root,COG0336@2|Bacteria,1ZT8K@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT HSJS3_k127_2148488_17 1122247.C731_1727 7.76e-31 128.0 COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,238SB@1762|Mycobacteriaceae 201174|Actinobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0008150,GO:0040007 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM HSJS3_k127_2148488_20 485913.Krac_1372 4.109e-18 94.0 COG0228@1|root,COG0228@2|Bacteria,2G7A3@200795|Chloroflexi 200795|Chloroflexi J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 HSJS3_k127_2148488_2 246194.CHY_2670 3.812e-136 445.0 COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,42FKX@68295|Thermoanaerobacterales 186801|Clostridia F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt HSJS3_k127_2148488_13 379066.GAU_0904 2.484e-56 208.0 COG0329@1|root,COG0329@2|Bacteria,1ZTGV@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS HSJS3_k127_2148488_12 379066.GAU_0902 3.384e-57 214.0 COG0111@1|root,COG0111@2|Bacteria,1ZUG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C HSJS3_k127_2148488_4 861299.J421_2799 9.246e-119 390.0 COG0180@1|root,COG0180@2|Bacteria,1ZT3P@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b HSJS3_k127_2148488_11 497321.C664_00085 7.954e-59 218.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,2KVHM@206389|Rhodocyclales 206389|Rhodocyclales G COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P HSJS3_k127_2148488_18 1487953.JMKF01000006_gene5651 6.554e-26 114.0 COG3238@1|root,COG3238@2|Bacteria 2|Bacteria S Putative inner membrane exporter, YdcZ - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ HSJS3_k127_2148488_10 1379270.AUXF01000004_gene3061 1.858e-66 235.0 COG1842@1|root,COG1842@2|Bacteria,1ZT82@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 HSJS3_k127_2148488_19 744872.Spica_0231 7.601e-25 109.0 2E9HN@1|root,333QR@2|Bacteria,2J8QF@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - HSJS3_k127_2148488_22 234267.Acid_1816 8.226e-05 45.0 COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria 2|Bacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran HSJS3_k127_2446879_0 861299.J421_2748 0.0 1282.0 COG0178@1|root,COG0178@2|Bacteria,1ZTDJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran HSJS3_k127_2446879_1 1149133.ppKF707_5258 1.339e-81 286.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1YDTP@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC HSJS3_k127_2446879_2 313612.L8106_30660 2.423e-13 76.0 COG1597@1|root,COG1597@2|Bacteria,1G25B@1117|Cyanobacteria,1H9PD@1150|Oscillatoriales 1117|Cyanobacteria GI PFAM Diacylglycerol kinase, catalytic domain - - - - - - - - - - - - DAGK_cat HSJS3_k127_2517247_13 1336241.JAEB01000001_gene92 3.538e-12 66.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,25UVU@186806|Eubacteriaceae 186801|Clostridia O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C HSJS3_k127_2517247_4 697281.Mahau_2620 8.773e-145 474.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,42FJ3@68295|Thermoanaerobacterales 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C HSJS3_k127_2517247_7 1379270.AUXF01000006_gene204 4.324e-66 233.0 COG1573@1|root,COG1573@2|Bacteria,1ZTG5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG HSJS3_k127_2517247_6 999423.HMPREF9161_01599 7.846e-95 325.0 COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4H27H@909932|Negativicutes 909932|Negativicutes H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein HSJS3_k127_2517247_12 861299.J421_3320 1.493e-12 70.0 28VAR@1|root,2ZHDJ@2|Bacteria,1ZU25@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - - - - - - - - - - - RNA_pol_Rpb6 HSJS3_k127_2517247_10 1120972.AUMH01000007_gene1712 5.999e-50 188.0 COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,4HAYW@91061|Bacilli,278AT@186823|Alicyclobacillaceae 91061|Bacilli F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU15680 Guanylate_kin HSJS3_k127_2517247_9 861299.J421_3322 4.314e-52 195.0 COG1561@1|root,COG1561@2|Bacteria,1ZT99@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N HSJS3_k127_2517247_1 1121403.AUCV01000021_gene3556 7.5e-177 563.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria,2MI0G@213118|Desulfobacterales 28221|Deltaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh HSJS3_k127_2517247_5 1048834.TC41_2347 8.608e-116 383.0 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae 91061|Bacilli C Citrate synthase, C-terminal domain citZ - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt HSJS3_k127_2517247_2 1191523.MROS_1660 6.264e-162 520.0 COG4992@1|root,COG4992@2|Bacteria 2|Bacteria E N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity rocD GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 ko:K00819,ko:K00821 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R00667,R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iYO844.BSU40340 Aminotran_3 HSJS3_k127_2517247_8 1123392.AQWL01000001_gene1423 6.801e-60 213.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,1KSPA@119069|Hydrogenophilales 119069|Hydrogenophilales O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase HSJS3_k127_2517247_11 452637.Oter_2111 8.398e-20 99.0 COG0204@1|root,COG0204@2|Bacteria,46SYR@74201|Verrucomicrobia,3K7W9@414999|Opitutae 414999|Opitutae I Glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase HSJS3_k127_2517247_0 471852.Tcur_1749 0.0 1137.0 COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4EGQX@85012|Streptosporangiales 201174|Actinobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C HSJS3_k127_2517247_3 945713.IALB_0608 3.22e-160 530.0 COG3591@1|root,COG3591@2|Bacteria 2|Bacteria E Belongs to the peptidase S1B family - - - - - - - - - - - - Peptidase_S46 HSJS3_k127_2529506_42 485913.Krac_8410 6.312e-15 75.0 COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi 200795|Chloroflexi E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N HSJS3_k127_2529506_21 584708.Apau_0126 1.798e-102 359.0 COG1228@1|root,COG1228@2|Bacteria,3TAMY@508458|Synergistetes 508458|Synergistetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 HSJS3_k127_2529506_17 584708.Apau_0124 7.933e-113 371.0 COG3643@1|root,COG3643@2|Bacteria,3TA3X@508458|Synergistetes 508458|Synergistetes E Formiminotransferase domain, N-terminal subdomain - - - - - - - - - - - - FTCD,FTCD_N HSJS3_k127_2529506_35 469381.Dpep_1498 6.644e-36 143.0 COG3404@1|root,COG3404@2|Bacteria,3TB0V@508458|Synergistetes 508458|Synergistetes E PFAM Formiminotransferase-cyclodeaminase - - - - - - - - - - - - FTCD_C HSJS3_k127_2529506_11 555079.Toce_1476 2.924e-124 417.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,42FDT@68295|Thermoanaerobacterales 186801|Clostridia E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic HSJS3_k127_2529506_0 1089552.KI911559_gene662 5.408e-235 737.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JQSD@204441|Rhodospirillales 204441|Rhodospirillales C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP HSJS3_k127_2529506_1 398767.Glov_2687 9.996e-219 690.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42N1B@68525|delta/epsilon subdivisions,2WJWS@28221|Deltaproteobacteria,43UDG@69541|Desulfuromonadales 28221|Deltaproteobacteria C PFAM FAD dependent oxidoreductase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C HSJS3_k127_2529506_23 880073.Calab_1414 2.441e-95 320.0 COG0388@1|root,COG0388@2|Bacteria,2NPKU@2323|unclassified Bacteria 2|Bacteria S Carbon-nitrogen hydrolase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase HSJS3_k127_2529506_31 326427.Cagg_3740 6.137e-54 201.0 COG0697@1|root,COG0697@2|Bacteria,2G7RS@200795|Chloroflexi,377VC@32061|Chloroflexia 32061|Chloroflexia EG EamA-like transporter family - - - - - - - - - - - - EamA HSJS3_k127_2529506_27 686578.AFFX01000003_gene40 7.032e-69 242.0 COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,1RY5U@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059,ko:K18335 ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R10690,R11671 RC00029,RC00089,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 HSJS3_k127_2529506_10 479434.Sthe_3153 4.744e-126 430.0 COG1108@1|root,COG1108@2|Bacteria,2G7XS@200795|Chloroflexi 200795|Chloroflexi P PFAM ABC-3 protein - - - ko:K11709 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC-3 HSJS3_k127_2529506_15 880073.Calab_1771 2.953e-114 379.0 COG1108@1|root,COG1108@2|Bacteria,2NPC2@2323|unclassified Bacteria 2|Bacteria U ABC 3 transport family mntC GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0010035,GO:0010038,GO:0010043,GO:0016020,GO:0042221,GO:0044464,GO:0050896,GO:0071944 - ko:K11708 ko02010,map02010 M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ABC-3,Fe_dep_repr_C HSJS3_k127_2529506_19 880073.Calab_1772 2.533e-110 370.0 COG1121@1|root,COG1121@2|Bacteria,2NPKC@2323|unclassified Bacteria 2|Bacteria P ATPases associated with a variety of cellular activities mntB - - ko:K09817,ko:K11710 ko02010,map02010 M00242,M00319 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - iYO844.BSU30760 ABC_tran HSJS3_k127_2529506_20 479434.Sthe_3156 1.79e-105 351.0 COG0803@1|root,COG0803@2|Bacteria,2G8F6@200795|Chloroflexi,27XHP@189775|Thermomicrobia 200795|Chloroflexi P Belongs to the bacterial solute-binding protein 9 family - - - ko:K09818,ko:K11707 ko02010,map02010 M00243,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ZnuA HSJS3_k127_2529506_2 298655.KI912266_gene1062 5.884e-193 615.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales 201174|Actinobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt HSJS3_k127_2529506_32 861299.J421_0143 1.059e-43 178.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase HSJS3_k127_2529506_6 861299.J421_6055 5.101e-150 488.0 COG2242@1|root,COG2242@2|Bacteria 2|Bacteria H protein methyltransferase activity - - 2.1.1.242,2.1.1.303,2.1.1.319 ko:K11434,ko:K15984,ko:K20421 ko01059,ko01130,ko04068,ko04922,map01059,map01130,map04068,map04922 M00830 R10963,R11216,R11217,R11219 RC00003,RC00392,RC02120,RC03388,RC03390 ko00000,ko00001,ko00002,ko01000,ko03009,ko03036 - - - DOT1,Methyltransf_21,Methyltransf_25 HSJS3_k127_2529506_16 1384056.N787_01985 2.801e-113 386.0 2DNHZ@1|root,32XM8@2|Bacteria,1QUVC@1224|Proteobacteria,1T3US@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_2529506_44 1313421.JHBV01000041_gene3666 1.273e-10 73.0 2BVG0@1|root,32QV2@2|Bacteria,4P3CR@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_2529506_41 1458462.JNLK01000001_gene1405 2.871e-16 93.0 COG1262@1|root,COG4886@1|root,COG1262@2|Bacteria,COG4886@2|Bacteria,1UPIY@1239|Firmicutes,25HHH@186801|Clostridia,27PD1@186928|unclassified Lachnospiraceae 186801|Clostridia S TIR domain - - - - - - - - - - - - TIR_2 HSJS3_k127_2529506_30 1353531.AZNX01000001_gene2563 1.634e-56 218.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_8 HSJS3_k127_2529506_34 1123253.AUBD01000008_gene477 6.039e-36 150.0 COG3621@1|root,COG3621@2|Bacteria,1R852@1224|Proteobacteria,1T0QF@1236|Gammaproteobacteria,1XD18@135614|Xanthomonadales 135614|Xanthomonadales S Patatin-like phospholipase - - - - - - - - - - - - Patatin HSJS3_k127_2529506_12 518766.Rmar_2201 2.507e-120 421.0 COG1629@1|root,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1FISC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec HSJS3_k127_2529506_39 649638.Trad_2776 6.543e-25 114.0 COG3346@1|root,COG3346@2|Bacteria 2|Bacteria S mitochondrial respiratory chain complex IV assembly surf1 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 HSJS3_k127_2529506_9 1139996.OMQ_02509 3.778e-127 414.0 COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,4HAIX@91061|Bacilli,4B1EW@81852|Enterococcaceae 91061|Bacilli S SigmaW regulon antibacterial yqfA - - - - - - - - - - - YdfA_immunity HSJS3_k127_2529506_22 945713.IALB_2104 1.397e-95 329.0 COG1030@1|root,COG1030@2|Bacteria 2|Bacteria - - nfeD - - ko:K07403 - - - - ko00000 - - - NfeD,Peptidase_S49,SDH_sah HSJS3_k127_2529506_14 1379698.RBG1_1C00001G0806 7.262e-117 383.0 COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria 2|Bacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 HSJS3_k127_2529506_3 1379698.RBG1_1C00001G0805 3.621e-188 599.0 COG1012@1|root,COG1012@2|Bacteria,2NNWB@2323|unclassified Bacteria 2|Bacteria C Belongs to the aldehyde dehydrogenase family aldH - 1.2.1.3 ko:K00128,ko:K00138 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh HSJS3_k127_2529506_7 562970.Btus_1243 5.783e-149 483.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,277YV@186823|Alicyclobacillaceae 91061|Bacilli I Belongs to the thiolase family pcaF - 2.3.1.174,2.3.1.223,2.3.1.9 ko:K00626,ko:K02615 ko00071,ko00072,ko00280,ko00310,ko00360,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00360,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R00829,R01177,R09839 RC00004,RC00326,RC03003 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N HSJS3_k127_2529506_28 439235.Dalk_1739 6.636e-63 226.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,42ZTX@68525|delta/epsilon subdivisions,2WVID@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - iAF987.Gmet_2224 ECH_1 HSJS3_k127_2529506_24 309800.C498_00445 1.603e-89 304.0 COG1250@1|root,arCOG00250@2157|Archaea,2XT9S@28890|Euryarchaeota,23TDY@183963|Halobacteria 183963|Halobacteria I 3-hydroxyacyl-CoA dehydrogenase hbd3 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N HSJS3_k127_2529506_26 1227497.C491_04165 6.634e-80 274.0 COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,23SMM@183963|Halobacteria 183963|Halobacteria I Belongs to the enoyl-CoA hydratase isomerase family ech4 - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 HSJS3_k127_2529506_36 1394175.AWUN01000002_gene798 3.839e-32 126.0 COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4D19N@85004|Bifidobacteriales 201174|Actinobacteria J Ribosomal L27 protein rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 HSJS3_k127_2529506_38 926559.JoomaDRAFT_1699 8.332e-29 123.0 COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,4NSHE@976|Bacteroidetes,1HYAI@117743|Flavobacteriia 976|Bacteroidetes J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Rho_N,Ribosomal_L21p HSJS3_k127_2529506_13 1499967.BAYZ01000029_gene1223 2.498e-118 400.0 COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria 2|Bacteria J Ribonuclease E/G family rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 HSJS3_k127_2529506_5 379066.GAU_1701 9.219e-151 493.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - ko:K18244 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N HSJS3_k127_2529506_40 379066.GAU_0126 1.634e-23 113.0 2EY2H@1|root,33RBE@2|Bacteria,1ZTHK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_2529506_25 1122613.ATUP01000001_gene345 8.54e-88 304.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,2TS8B@28211|Alphaproteobacteria,43WI8@69657|Hyphomonadaceae 28211|Alphaproteobacteria L helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind HSJS3_k127_2529506_33 331678.Cphamn1_0501 1.375e-42 161.0 COG2010@1|root,COG2010@2|Bacteria,1FEAI@1090|Chlorobi 1090|Chlorobi C Haem-binding domain - - - - - - - - - - - - Haem_bd HSJS3_k127_2529506_46 1121949.AQXT01000002_gene1601 5.568e-09 66.0 2ECN7@1|root,32Y4C@2|Bacteria,1NEKK@1224|Proteobacteria,2UXB7@28211|Alphaproteobacteria,440JV@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_2529506_45 566466.NOR53_903 2.03e-09 68.0 2EMUX@1|root,33FH7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_2529506_18 1234664.AMRO01000079_gene553 4.169e-111 372.0 COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,4HA9Z@91061|Bacilli,1WHRQ@129337|Geobacillus 91061|Bacilli C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N HSJS3_k127_2529506_8 345341.KUTG_04232 4.361e-146 479.0 COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria,4DZ9X@85010|Pseudonocardiales 201174|Actinobacteria S Aldo keto - - - - - - - - - - - - Aldo_ket_red HSJS3_k127_2529506_47 338963.Pcar_2432 0.0001224 52.0 2C46F@1|root,32SRD@2|Bacteria,1N540@1224|Proteobacteria,42UJ6@68525|delta/epsilon subdivisions,2WQUS@28221|Deltaproteobacteria,43SNI@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_2529506_29 309807.SRU_1476 1.503e-56 206.0 COG1024@1|root,COG1024@2|Bacteria,4NI32@976|Bacteroidetes,1FIVI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 HSJS3_k127_2529506_37 234267.Acid_3872 1.061e-30 138.0 2CIU6@1|root,32S8H@2|Bacteria,3Y8IT@57723|Acidobacteria 57723|Acidobacteria - - - - - - - - - - - - - - - HSJS3_k127_2529506_4 861299.J421_3345 3.211e-153 492.0 COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA HSJS3_k127_2610240_1 330214.NIDE3598 3.741e-58 205.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase - - - - - - - - - - - - NmrA HSJS3_k127_2610240_2 379066.GAU_3750 2.319e-21 110.0 COG0515@1|root,COG0515@2|Bacteria,1ZURQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase HSJS3_k127_2610240_0 518766.Rmar_2008 7.149e-194 614.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1FJ1P@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh HSJS3_k127_2610240_3 278963.ATWD01000001_gene3445 6.703e-20 104.0 COG1352@1|root,COG2201@1|root,COG4191@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4191@2|Bacteria,3Y45J@57723|Acidobacteria,2JMHU@204432|Acidobacteriia 204432|Acidobacteriia T CheR methyltransferase, all-alpha domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10 HSJS3_k127_2647722_10 861299.J421_3420 3.249e-96 324.0 COG0539@1|root,COG0539@2|Bacteria,1ZSKI@142182|Gemmatimonadetes 142182|Gemmatimonadetes J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 HSJS3_k127_2647722_32 269796.Rru_A3728 1.07e-08 68.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VEYD@28211|Alphaproteobacteria,2JYKT@204441|Rhodospirillales 204441|Rhodospirillales E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 HSJS3_k127_2647722_16 1121468.AUBR01000038_gene1975 7.704e-57 216.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,42EV3@68295|Thermoanaerobacterales 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr HSJS3_k127_2647722_0 379066.GAU_1457 2.451e-201 641.0 COG1884@1|root,COG1884@2|Bacteria,1ZT5I@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase HSJS3_k127_2647722_29 1191523.MROS_1871 5.292e-19 93.0 COG2331@1|root,COG2331@2|Bacteria 2|Bacteria P Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 HSJS3_k127_2647722_3 1121346.KB899855_gene106 2.543e-145 481.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,4HAR3@91061|Bacilli,26R9D@186822|Paenibacillaceae 91061|Bacilli J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d HSJS3_k127_2647722_9 1379270.AUXF01000005_gene721 9.562e-106 354.0 COG0150@1|root,COG0150@2|Bacteria,1ZSQJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F AIR synthase related protein, C-terminal domain purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C HSJS3_k127_2647722_13 326427.Cagg_2639 2.578e-73 260.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G5SW@200795|Chloroflexi 200795|Chloroflexi H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 HSJS3_k127_2647722_20 1463845.JOIG01000002_gene2365 3.232e-43 177.0 COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria 201174|Actinobacteria H riboflavin synthase, alpha ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding HSJS3_k127_2647722_2 243231.GSU1690 5.101e-161 516.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43U14@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 HSJS3_k127_2647722_25 1192034.CAP_2889 4.634e-35 147.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2YV53@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase HSJS3_k127_2647722_27 1254432.SCE1572_42360 2.445e-22 103.0 COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2YVKR@29|Myxococcales 28221|Deltaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB HSJS3_k127_2647722_5 861299.J421_3119 6.364e-117 387.0 COG0438@1|root,COG0438@2|Bacteria,1ZTBC@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 HSJS3_k127_2647722_33 55601.VANGNB10_cI2285 7.631e-08 61.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1XXWR@135623|Vibrionales 135623|Vibrionales J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE HSJS3_k127_2647722_7 379066.GAU_1477 5.052e-116 381.0 COG1493@1|root,COG1493@2|Bacteria,1ZSY3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N HSJS3_k127_2647722_34 1122947.FR7_2992 0.00041 49.0 COG2893@1|root,COG2893@2|Bacteria,1VGY2@1239|Firmicutes,4H8HV@909932|Negativicutes 909932|Negativicutes G PTS system fructose IIA component - - - - - - - - - - - - EIIA-man HSJS3_k127_2647722_23 379066.GAU_1479 3.812e-37 147.0 COG3444@1|root,COG3444@2|Bacteria,1ZTQR@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose subfamily IIB component - - - ko:K19507 ko02060,map02060 M00764 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.19 - - PTSIIB_sorb HSJS3_k127_2647722_31 861299.J421_3124 5.319e-16 87.0 COG3715@1|root,COG3715@2|Bacteria,1ZTVH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system sorbose-specific iic component - - - ko:K02795 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EII-Sor HSJS3_k127_2647722_22 1379270.AUXF01000005_gene734 1.542e-40 162.0 COG3716@1|root,COG3716@2|Bacteria,1ZTJH@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS system mannose/fructose/sorbose family IID component - - - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EIID-AGA HSJS3_k127_2647722_28 861299.J421_3126 4.189e-20 103.0 COG1925@1|root,COG1925@2|Bacteria,1ZTYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes G PTS HPr component phosphorylation site - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr HSJS3_k127_2647722_8 1444309.JAQG01000016_gene683 6.099e-110 377.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,4H9VD@91061|Bacilli,26QD5@186822|Paenibacillaceae 91061|Bacilli G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) - - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C HSJS3_k127_2647722_4 335283.Neut_1893 1.238e-134 441.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,37280@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N HSJS3_k127_2647722_1 909663.KI867150_gene944 7.396e-166 534.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MQA7@213462|Syntrophobacterales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD HSJS3_k127_2647722_24 1379270.AUXF01000005_gene738 5.642e-37 146.0 COG1259@1|root,COG1259@2|Bacteria,1ZTKW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase HSJS3_k127_2647722_26 861299.J421_3130 2.949e-25 117.0 COG2010@1|root,COG2010@2|Bacteria,1ZT9T@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c - - - - - - - - - - - - - HSJS3_k127_2647722_19 1379270.AUXF01000005_gene740 1.957e-49 189.0 COG0614@1|root,COG0614@2|Bacteria,1ZTIM@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 HSJS3_k127_2647722_14 379066.GAU_0496 5.232e-69 250.0 COG0609@1|root,COG0609@2|Bacteria,1ZTAA@142182|Gemmatimonadetes 2|Bacteria P FecCD transport family btuC - 3.6.3.34 ko:K02013,ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - FecCD HSJS3_k127_2647722_18 861299.J421_3133 3.415e-50 190.0 COG1120@1|root,COG1120@2|Bacteria,1ZTB9@142182|Gemmatimonadetes 142182|Gemmatimonadetes P ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran HSJS3_k127_2647722_30 698769.JFBD01000014_gene2565 1.131e-17 92.0 COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,4HAHI@91061|Bacilli,4C4XC@84406|Virgibacillus 91061|Bacilli L Involved in DNA repair and RecF pathway recombination recO GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N HSJS3_k127_2647722_6 644282.Deba_2879 2.623e-116 404.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria 28221|Deltaproteobacteria J elongation factor SelB, winged helix selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 HSJS3_k127_2647722_17 861299.J421_3386 2.635e-55 199.0 COG1762@1|root,COG1762@2|Bacteria,1ZTIY@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 HSJS3_k127_2647722_21 861299.J421_0057 4.954e-41 158.0 COG0782@1|root,COG0782@2|Bacteria,1ZTPD@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcription elongation factor, N-terminal - - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N HSJS3_k127_2647722_15 861299.J421_3475 2.154e-59 218.0 COG1463@1|root,COG1463@2|Bacteria 2|Bacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component ttg2C - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD HSJS3_k127_2647722_12 861299.J421_3476 2.154e-76 267.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 2|Bacteria Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran HSJS3_k127_2647722_11 861299.J421_3477 1.114e-81 280.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE HSJS3_k127_2720232_0 1254432.SCE1572_05370 2.297e-78 284.0 COG0515@1|root,COG1672@1|root,COG2319@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,4328Z@68525|delta/epsilon subdivisions,2X7NM@28221|Deltaproteobacteria,2YXMY@29|Myxococcales 28221|Deltaproteobacteria T SMART serine threonine protein kinase - - - - - - - - - - - - Peptidase_C14,Pkinase,WD40 HSJS3_k127_2745265_3 1142394.PSMK_07130 0.000541 51.0 2DE5W@1|root,2ZKMK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_2745265_1 861299.J421_3564 1.012e-58 211.0 COG2003@1|root,COG2003@2|Bacteria,1ZTFU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E RadC-like JAB domain - - - ko:K03630 - - - - ko00000 - - - RadC HSJS3_k127_2745265_0 264732.Moth_1680 1.153e-215 692.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS HSJS3_k127_2745265_2 1313301.AUGC01000003_gene2105 4.229e-19 104.0 COG0556@1|root,COG0556@2|Bacteria,4NE6E@976|Bacteroidetes 976|Bacteroidetes L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB HSJS3_k127_2794107_3 452637.Oter_0317 2.829e-45 171.0 COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,46TQD@74201|Verrucomicrobia,3K9P1@414999|Opitutae 414999|Opitutae T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA HSJS3_k127_2794107_1 1108045.GORHZ_084_00430 1.426e-78 274.0 COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria,4GEP0@85026|Gordoniaceae 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 HSJS3_k127_2794107_2 1279009.ADICEAN_00204 2.408e-47 180.0 COG2940@1|root,COG2940@2|Bacteria,4NM5I@976|Bacteroidetes,47WYB@768503|Cytophagia 976|Bacteroidetes S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - - - - - - - - - - SET HSJS3_k127_2794107_0 1322246.BN4_12700 2.886e-201 642.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1MX4I@1224|Proteobacteria,42N4T@68525|delta/epsilon subdivisions,2WJK8@28221|Deltaproteobacteria,2MG4R@213115|Desulfovibrionales 28221|Deltaproteobacteria K Carbon-nitrogen hydrolase - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase HSJS3_k127_2821583_13 430498.S8C049 1.389e-07 53.0 COG0277@1|root,2QUMR@2759|Eukaryota,39PB1@33154|Opisthokonta,3P020@4751|Fungi,3QS9W@4890|Ascomycota 4751|Fungi C fad binding domain-containing protein - - - - - - - - - - - - BBE,FAD_binding_4 HSJS3_k127_2821583_14 335283.Neut_2211 2.545e-05 50.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria,373P5@32003|Nitrosomonadales 28216|Betaproteobacteria U MarC family integral membrane protein marC - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC HSJS3_k127_2821583_5 1122604.JONR01000004_gene852 6.063e-62 239.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_2821583_0 1121930.AQXG01000001_gene1489 1.558e-148 487.0 COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,4NGF6@976|Bacteroidetes,1IRGD@117747|Sphingobacteriia 976|Bacteroidetes P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N HSJS3_k127_2821583_2 518766.Rmar_2792 1.625e-86 298.0 COG3509@1|root,COG3509@2|Bacteria,4NENB@976|Bacteroidetes,1FJW7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 HSJS3_k127_2821583_1 485918.Cpin_0564 4.401e-87 306.0 COG1649@1|root,COG1649@2|Bacteria,4NGFW@976|Bacteroidetes,1IR69@117747|Sphingobacteriia 976|Bacteroidetes S Glycosyl hydrolase-like 10 - - - - - - - - - - - - CBM9_1,GHL10 HSJS3_k127_2821583_8 1286632.P278_03710 1.848e-35 139.0 COG2044@1|root,COG2044@2|Bacteria,4P2I4@976|Bacteroidetes,1I8SH@117743|Flavobacteriia 976|Bacteroidetes S DsrE/DsrF-like family - - - - - - - - - - - - DrsE HSJS3_k127_2821583_7 396588.Tgr7_1712 5.393e-46 173.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_2821583_11 396588.Tgr7_1713 1.237e-10 69.0 COG5662@1|root,COG5662@2|Bacteria 2|Bacteria K AntiSigma factor rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - - - - - - - - - - zf-HC2 HSJS3_k127_2821583_10 243159.AFE_2557 1.592e-18 90.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,2ND82@225057|Acidithiobacillales 225057|Acidithiobacillales O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA HSJS3_k127_2821583_4 637389.Acaty_c2196 4.251e-66 228.0 COG2210@1|root,COG2210@2|Bacteria,1RCMJ@1224|Proteobacteria,1S2XA@1236|Gammaproteobacteria,2NCNX@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 HSJS3_k127_2821583_6 1122604.JONR01000004_gene853 7.605e-58 226.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - HSJS3_k127_2821583_12 635013.TherJR_1023 5.193e-08 65.0 COG3391@1|root,COG3391@2|Bacteria,1VCN6@1239|Firmicutes 1239|Firmicutes S PFAM NHL repeat containing protein - - - - - - - - - - - - NHL HSJS3_k127_2821583_3 1297742.A176_01806 9.207e-74 266.0 COG2755@1|root,COG2755@2|Bacteria 2|Bacteria E lipolytic protein G-D-S-L family - - - - - - - - - - - - - HSJS3_k127_2821583_9 1082933.MEA186_06603 6.186e-22 104.0 29CEM@1|root,2ZZD2@2|Bacteria,1RE7K@1224|Proteobacteria,2U91P@28211|Alphaproteobacteria,43JT0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_2839724_2 382464.ABSI01000011_gene2578 3.915e-34 148.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C HSJS3_k127_2839724_1 382464.ABSI01000011_gene2578 2.331e-74 276.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C HSJS3_k127_2839724_0 314285.KT71_13030 1.64e-191 609.0 COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,1RY1C@1236|Gammaproteobacteria,1J7RH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase HSJS3_k127_2857955_21 1443111.JASG01000004_gene2963 2.147e-12 69.0 COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria,3ZVI2@60136|Sulfitobacter 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD HSJS3_k127_2857955_16 530564.Psta_3548 8.604e-44 165.0 COG2062@1|root,COG2062@2|Bacteria,2J0N8@203682|Planctomycetes 203682|Planctomycetes T phosphohistidine phosphatase, SixA - - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 HSJS3_k127_2857955_19 1337093.MBE-LCI_0227 7.301e-22 103.0 COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_7,DUF4437 HSJS3_k127_2857955_20 1502852.FG94_01152 1.553e-20 100.0 COG2771@1|root,COG2771@2|Bacteria,1NAK1@1224|Proteobacteria,2VY3K@28216|Betaproteobacteria,477Y7@75682|Oxalobacteraceae 28216|Betaproteobacteria K Protein of unknown function (DUF4019) - - - - - - - - - - - - DUF4019 HSJS3_k127_2857955_11 382464.ABSI01000012_gene2198 1.262e-56 224.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C HSJS3_k127_2857955_9 225937.HP15_2642 3.118e-65 229.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT HSJS3_k127_2857955_7 382464.ABSI01000012_gene2201 1.274e-73 274.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C HSJS3_k127_2857955_6 1300345.LF41_2593 6.048e-80 292.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_2857955_18 379066.GAU_3378 3.362e-37 150.0 2DCAE@1|root,2ZDF3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_2857955_8 1379270.AUXF01000002_gene1290 9.124e-71 268.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase HSJS3_k127_2857955_15 234267.Acid_5194 2.136e-44 171.0 COG1765@1|root,COG1765@2|Bacteria 2|Bacteria O OsmC-like protein - - - - - - - - - - - - OsmC HSJS3_k127_2857955_3 234267.Acid_5193 1.282e-93 317.0 COG0500@1|root,COG2226@2|Bacteria,3Y5GM@57723|Acidobacteria 57723|Acidobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 HSJS3_k127_2857955_22 391623.TERMP_02098 1.562e-07 63.0 COG1524@1|root,arCOG01378@2157|Archaea 2157|Archaea S type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest HSJS3_k127_2857955_14 290512.Paes_1282 3.446e-48 197.0 COG1629@1|root,COG4771@2|Bacteria,1FF1C@1090|Chlorobi 1090|Chlorobi M Outer membrane protein beta-barrel family - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec HSJS3_k127_2857955_13 861299.J421_0272 1.403e-48 182.0 COG2197@1|root,COG2197@2|Bacteria,1ZTJ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg HSJS3_k127_2857955_0 861299.J421_0271 6.336e-148 488.0 COG4585@1|root,COG4585@2|Bacteria,1ZSM2@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Histidine kinase - - - - - - - - - - - - HisKA_3 HSJS3_k127_2857955_10 398767.Glov_2398 6.809e-62 233.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42R04@68525|delta/epsilon subdivisions,2WMZ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM ATPase, BadF BadG BcrA BcrD type - - - - - - - - - - - - BcrAD_BadFG HSJS3_k127_2857955_5 398767.Glov_2399 9.766e-87 310.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family yjiL - - - - - - - - - - - BcrAD_BadFG HSJS3_k127_2857955_1 398767.Glov_2400 1.735e-123 409.0 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,430HE@68525|delta/epsilon subdivisions,2WVZI@28221|Deltaproteobacteria,43V4N@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D HSJS3_k127_2857955_2 398767.Glov_2401 1.009e-107 372.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D HSJS3_k127_2857955_17 1244869.H261_03143 6.854e-43 168.0 COG1024@1|root,COG1024@2|Bacteria,1R8QP@1224|Proteobacteria,2UNSE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.100 ko:K07537 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05597 RC03168 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 HSJS3_k127_2857955_4 1187851.A33M_3194 7.486e-93 310.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 HSJS3_k127_2913501_6 314285.KT71_03017 1.511e-72 269.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - HSJS3_k127_2913501_7 382464.ABSI01000012_gene2201 2.907e-68 255.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C HSJS3_k127_2913501_2 1280950.HJO_13121 3.045e-80 290.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C HSJS3_k127_2913501_4 566466.NOR53_3413 1.733e-76 281.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_2913501_5 1280950.HJO_13121 1.378e-74 274.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C HSJS3_k127_2913501_3 1280950.HJO_13121 1.181e-76 280.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C HSJS3_k127_2913501_10 861299.J421_1863 5.988e-27 128.0 COG0515@1|root,COG3629@1|root,COG0515@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C HSJS3_k127_2913501_13 1122604.JONR01000025_gene4602 6.462e-08 66.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C HSJS3_k127_2913501_9 1121920.AUAU01000006_gene301 7.624e-41 158.0 2BYAB@1|root,32R2Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_2913501_8 1132509.C447_01340 4.452e-65 232.0 COG0614@1|root,arCOG04233@2157|Archaea,2XU02@28890|Euryarchaeota,23SZW@183963|Halobacteria 183963|Halobacteria P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 HSJS3_k127_2913501_1 322710.Avin_20870 2.869e-140 465.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_7 HSJS3_k127_2913501_12 1380390.JIAT01000009_gene1359 1.402e-10 74.0 COG3391@1|root,COG3391@2|Bacteria,2GWAV@201174|Actinobacteria,4CRHS@84995|Rubrobacteria 84995|Rubrobacteria S WD40 repeats - - - - - - - - - - - - NHL HSJS3_k127_2913501_11 59931.WH7805_04131 8.651e-20 94.0 COG0640@1|root,COG0640@2|Bacteria,1G7S2@1117|Cyanobacteria,1H15N@1129|Synechococcus 1117|Cyanobacteria K arsR family arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 HSJS3_k127_2913501_0 903818.KI912269_gene530 1.226e-153 497.0 COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria 57723|Acidobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions - - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK HSJS3_k127_2928633_3 1122603.ATVI01000005_gene3497 1.852e-70 263.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - HSJS3_k127_2928633_0 189753.AXAS01000005_gene670 1.027e-91 338.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTD5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T AAA ATPase domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,DZR,Guanylate_cyc,TPR_12 HSJS3_k127_2928633_11 713586.KB900536_gene1288 2.858e-23 113.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1WYN6@135613|Chromatiales 135613|Chromatiales K SMART cyclic nucleotide-binding - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding HSJS3_k127_2928633_1 1379270.AUXF01000003_gene3595 1.041e-87 315.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria 2|Bacteria S metallopeptidase activity - - - ko:K01993,ko:K13408,ko:K16922 ko04626,map04626 M00339 - - ko00000,ko00001,ko00002,ko01002,ko02000,ko02044 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 HSJS3_k127_2928633_10 1379270.AUXF01000003_gene3596 1.569e-24 116.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 HSJS3_k127_2928633_6 1379270.AUXF01000003_gene3597 3.611e-66 249.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K01993,ko:K16922 - - - - ko00000,ko01002 - - - HlyD_3 HSJS3_k127_2928633_8 861299.J421_0886 2.691e-46 175.0 COG1595@1|root,COG1595@2|Bacteria,1ZUWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF HSJS3_k127_2928633_2 1267533.KB906733_gene3362 5.091e-82 303.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C HSJS3_k127_2928633_4 1379270.AUXF01000001_gene2437 6.726e-68 260.0 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1ZUTN@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Tetratricopeptide repeat - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_8 HSJS3_k127_2928633_9 1047013.AQSP01000131_gene1797 3.54e-34 149.0 COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria 2|Bacteria U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 HSJS3_k127_2928633_5 379066.GAU_0689 1.378e-66 257.0 COG1629@1|root,COG4771@2|Bacteria,1ZUP3@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg HSJS3_k127_2928633_7 1122603.ATVI01000006_gene303 1.202e-47 195.0 2DGSK@1|root,2ZX56@2|Bacteria,1P4YM@1224|Proteobacteria,1SVUB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_304983_26 1121104.AQXH01000003_gene404 1.057e-48 179.0 COG0415@1|root,COG0415@2|Bacteria 2|Bacteria L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 HSJS3_k127_304983_19 1500893.JQNB01000001_gene2383 1.622e-68 243.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,1RYRE@1236|Gammaproteobacteria,1X4DI@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - DUF1295 HSJS3_k127_304983_15 404589.Anae109_3008 1.089e-91 312.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2YW8F@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 HSJS3_k127_304983_4 756272.Plabr_0145 2.652e-189 602.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 HSJS3_k127_304983_22 452637.Oter_1107 9.965e-61 222.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,46V45@74201|Verrucomicrobia 74201|Verrucomicrobia K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 HSJS3_k127_304983_24 530564.Psta_1181 2.87e-58 206.0 COG2335@1|root,COG2335@2|Bacteria,2IZDI@203682|Planctomycetes 203682|Planctomycetes M COG2335 Secreted and surface protein containing fasciclin-like repeats - - - - - - - - - - - - Fasciclin HSJS3_k127_304983_16 1123009.AUID01000002_gene2160 5.447e-84 288.0 COG2335@1|root,COG2335@2|Bacteria,1VDJ1@1239|Firmicutes,24DID@186801|Clostridia 186801|Clostridia M Beta-Ig-H3 fasciclin - - - - - - - - - - - - Cu_amine_oxidN1,Fasciclin HSJS3_k127_304983_36 525897.Dbac_2439 1.365e-32 131.0 COG4852@1|root,COG4852@2|Bacteria,1MZHP@1224|Proteobacteria,42TD7@68525|delta/epsilon subdivisions,2WPIH@28221|Deltaproteobacteria,2MF5C@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2177) - - - - - - - - - - - - DUF2177 HSJS3_k127_304983_31 861299.J421_1545 6.314e-43 179.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1ZTSR@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial transcriptional activator domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - BTAD HSJS3_k127_304983_20 1265313.HRUBRA_00432 1.957e-68 250.0 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,1T0QH@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG4257 Streptogramin lyase - - - - - - - - - - - - CarboxypepD_reg HSJS3_k127_304983_17 1499967.BAYZ01000065_gene6085 1.965e-75 265.0 COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria 2|Bacteria E Ornithine cyclodeaminase/mu-crystallin family rapL - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall HSJS3_k127_304983_7 1210884.HG799465_gene11386 1.376e-172 556.0 COG4948@1|root,COG4948@2|Bacteria,2IY85@203682|Planctomycetes 203682|Planctomycetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 4.2.1.171 ko:K21624 ko00330,map00330 - R11625 - ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N HSJS3_k127_304983_3 1121930.AQXG01000001_gene1298 2.532e-196 638.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia 976|Bacteroidetes S cellulase activity - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_304983_39 1122179.KB890438_gene1588 8.438e-10 61.0 COG0346@1|root,COG0346@2|Bacteria,4NQIE@976|Bacteroidetes,1IT14@117747|Sphingobacteriia 976|Bacteroidetes E glyoxalase - - - - - - - - - - - - Glyoxalase HSJS3_k127_304983_13 671143.DAMO_2906 4.715e-121 400.0 COG2132@1|root,COG2132@2|Bacteria 2|Bacteria Q Multicopper oxidase - - 1.16.3.3,1.7.2.1 ko:K00368,ko:K22348 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,SdrD_B,TIG,fn3_3 HSJS3_k127_304983_27 1336233.JAEH01000055_gene4125 1.647e-46 179.0 COG0491@1|root,COG0491@2|Bacteria,1PBSA@1224|Proteobacteria,1SWGM@1236|Gammaproteobacteria,2QE2R@267890|Shewanellaceae 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B HSJS3_k127_304983_12 1379270.AUXF01000002_gene1584 1.924e-129 437.0 COG2132@1|root,COG2132@2|Bacteria,1ZUD9@142182|Gemmatimonadetes 2|Bacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22348 - - - - ko00000,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 HSJS3_k127_304983_37 876269.ARWA01000001_gene1218 1.244e-20 104.0 COG0412@1|root,COG0412@2|Bacteria,1R5J6@1224|Proteobacteria,2UE6V@28211|Alphaproteobacteria,3NBMH@45404|Beijerinckiaceae 28211|Alphaproteobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH,Peptidase_S9 HSJS3_k127_304983_29 1237149.C900_00788 3.416e-44 166.0 COG0251@1|root,COG0251@2|Bacteria,4NPF9@976|Bacteroidetes,47QAB@768503|Cytophagia 976|Bacteroidetes J translation initiation inhibitor, yjgF family - - - - - - - - - - - - YjgF_endoribonc HSJS3_k127_304983_25 67373.JOBF01000036_gene4709 8.068e-49 192.0 COG2730@1|root,COG3386@1|root,COG2730@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Calx-beta,Cellulase,NHL,RicinB_lectin_2 HSJS3_k127_304983_41 1502850.FG91_00795 2.808e-05 57.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1R5P1@1224|Proteobacteria,2U0ZV@28211|Alphaproteobacteria,2KEB5@204457|Sphingomonadales 204457|Sphingomonadales QU amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3,PD40 HSJS3_k127_304983_28 880073.Calab_2215 1.704e-45 190.0 COG1629@1|root,COG4771@2|Bacteria,2NP6Z@2323|unclassified Bacteria 2|Bacteria P COGs COG1629 Outer membrane receptor protein mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec HSJS3_k127_304983_32 491952.Mar181_1354 3.899e-41 155.0 COG0558@1|root,COG0558@2|Bacteria 2|Bacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iSB619.SA_RS06365 CDP-OH_P_transf HSJS3_k127_304983_11 861299.J421_3134 7.691e-132 443.0 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec HSJS3_k127_304983_2 511062.GU3_12660 3.021e-201 641.0 COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,1RXZF@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q nitrite reductase nirK - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cytochrom_C,Cytochrome_CBB3 HSJS3_k127_304983_30 945713.IALB_0862 2.344e-43 175.0 COG3203@1|root,COG3203@2|Bacteria 2|Bacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Alginate_exp,BBP2,MucBP,Porin_4,SLH HSJS3_k127_304983_6 861299.J421_4527 1.071e-174 562.0 COG0673@1|root,COG0673@2|Bacteria,1ZSW3@142182|Gemmatimonadetes 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C,TAT_signal HSJS3_k127_304983_21 1089550.ATTH01000001_gene2149 3.797e-67 243.0 COG2133@1|root,COG2133@2|Bacteria,4PKJE@976|Bacteroidetes,1FJG8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 HSJS3_k127_304983_1 1279017.AQYJ01000025_gene537 4.331e-297 923.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,463YB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Oxidoreductase neoG - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N HSJS3_k127_304983_23 1379270.AUXF01000001_gene1930 1.478e-58 214.0 2CISN@1|root,2Z7MB@2|Bacteria,1ZU2Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 HSJS3_k127_304983_5 1089550.ATTH01000001_gene2150 5.239e-185 593.0 COG0738@1|root,COG0738@2|Bacteria,4NFTC@976|Bacteroidetes 976|Bacteroidetes G Pfam Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 HSJS3_k127_304983_9 518766.Rmar_1734 3.575e-135 442.0 COG0673@1|root,COG0673@2|Bacteria,4NFMS@976|Bacteroidetes,1FJ32@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C HSJS3_k127_304983_8 518766.Rmar_1733 8.156e-158 511.0 COG1082@1|root,COG1082@2|Bacteria,4NGBE@976|Bacteroidetes,1FJ46@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N HSJS3_k127_304983_34 861299.J421_3015 8.559e-38 153.0 2DG4T@1|root,2ZUHN@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_304983_43 1410666.JHXG01000007_gene2255 0.0002947 52.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,4NEKW@976|Bacteroidetes,2FM5V@200643|Bacteroidia 976|Bacteroidetes M Transglycosylase SLT domain mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT HSJS3_k127_304983_18 1123320.KB889640_gene4470 8.414e-72 252.0 COG0702@1|root,COG0702@2|Bacteria 2|Bacteria GM epimerase - - - - - - - - - - - - NAD_binding_10,NmrA HSJS3_k127_304983_35 745411.B3C1_00785 7.427e-37 146.0 28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S2BA@1236|Gammaproteobacteria,1JAXR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - VP2004 - - - - - - - - - - - - HSJS3_k127_304983_38 518766.Rmar_2696 1.53e-11 73.0 COG2968@1|root,COG2968@2|Bacteria,4P8H6@976|Bacteroidetes,1FJN4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Membrane - - - - - - - - - - - - OMP_b-brl HSJS3_k127_304983_14 1121015.N789_00870 2.042e-98 329.0 COG4242@1|root,COG4242@2|Bacteria,1PR9J@1224|Proteobacteria,1RVJH@1236|Gammaproteobacteria 1236|Gammaproteobacteria PQ Belongs to the peptidase S51 family - - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 HSJS3_k127_304983_0 1121013.P873_12400 0.0 1246.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1X7FN@135614|Xanthomonadales 135614|Xanthomonadales HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,Mur_ligase_C,Mur_ligase_M,RimK HSJS3_k127_304983_10 391616.OA238_c34290 5.121e-132 441.0 COG0769@1|root,COG0769@2|Bacteria,1R52S@1224|Proteobacteria,2U1XC@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mur ligase family, glutamate ligase domain - - - - - - - - - - - - Mur_ligase_C,Mur_ligase_M HSJS3_k127_304983_40 1270193.JARP01000006_gene1554 1.873e-08 62.0 COG4319@1|root,COG4319@2|Bacteria,4PACD@976|Bacteroidetes,1I8R0@117743|Flavobacteriia,2NXUF@237|Flavobacterium 976|Bacteroidetes S ketosteroid isomerase - - - - - - - - - - - - DUF4440 HSJS3_k127_3062399_4 795797.C497_01630 8.633e-110 363.0 COG3396@1|root,arCOG04786@2157|Archaea,2XU4A@28890|Euryarchaeota,23SMU@183963|Halobacteria 183963|Halobacteria Q Phenylacetate-CoA oxygenase subunit PaaA - - 1.14.13.149 ko:K02609 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC HSJS3_k127_3062399_0 518766.Rmar_1231 4.428e-219 696.0 COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,1FIW6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Aldehyde dehydrogenase family pruA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh HSJS3_k127_3062399_6 670487.Ocepr_0951 8.773e-97 319.0 COG0605@1|root,COG0605@2|Bacteria,1WIJ1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P radicals which are normally produced within the cells and which are toxic to biological systems sodA GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N HSJS3_k127_3062399_8 1210884.HG799470_gene14473 9.48e-79 277.0 COG4447@1|root,COG4447@2|Bacteria,2J0B6@203682|Planctomycetes 203682|Planctomycetes S cellulose binding - - - - - - - - - - - - PSII_BNR HSJS3_k127_3062399_12 886293.Sinac_6000 1.426e-63 229.0 COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes 203682|Planctomycetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.6 ko:K01431 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R00905,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase HSJS3_k127_3062399_7 671143.DAMO_2491 9.528e-94 315.0 COG1028@1|root,COG1028@2|Bacteria,2NQBD@2323|unclassified Bacteria 2|Bacteria IQ NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - - - - - - - - - - adh_short_C2 HSJS3_k127_3062399_1 1121930.AQXG01000016_gene1818 4.692e-208 661.0 COG1757@1|root,COG1757@2|Bacteria,4NFF8@976|Bacteroidetes 976|Bacteroidetes C Na H anti-porter mleN - - - - - - - - - - - Na_H_antiporter HSJS3_k127_3062399_11 1379270.AUXF01000003_gene3568 1.84e-67 240.0 COG0745@1|root,COG0745@2|Bacteria,1ZTC6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Transcriptional regulatory protein, C terminal - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C HSJS3_k127_3062399_9 269799.Gmet_2694 9.543e-78 281.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,43TY2@69541|Desulfuromonadales 28221|Deltaproteobacteria T Phosphate sensor histidine kinase, HAMP and PAS domain-containing phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like HSJS3_k127_3062399_13 1501391.LG35_00405 5.686e-06 58.0 COG3746@1|root,COG3746@2|Bacteria,4NK5I@976|Bacteroidetes,2FPVC@200643|Bacteroidia 976|Bacteroidetes P Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P HSJS3_k127_3062399_5 13035.Dacsa_1417 1.84e-109 362.0 COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM phosphate binding protein pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like,PBP_like_2 HSJS3_k127_3062399_3 926550.CLDAP_00830 5.721e-113 372.0 COG0573@1|root,COG0573@2|Bacteria,2G62J@200795|Chloroflexi 200795|Chloroflexi P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 HSJS3_k127_3062399_10 1173026.Glo7428_2340 3.804e-69 257.0 COG0581@1|root,COG0581@2|Bacteria,1G2GA@1117|Cyanobacteria 1117|Cyanobacteria P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 HSJS3_k127_3062399_2 329726.AM1_0174 2.658e-113 371.0 COG1117@1|root,COG1117@2|Bacteria,1G0P6@1117|Cyanobacteria 1117|Cyanobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran HSJS3_k127_3123862_1 861299.J421_3048 6.012e-208 660.0 COG0060@1|root,COG0060@2|Bacteria,1ZSKS@142182|Gemmatimonadetes 142182|Gemmatimonadetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 HSJS3_k127_3123862_27 562970.Btus_1326 2.75e-28 122.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,277XQ@186823|Alicyclobacillaceae 91061|Bacilli F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate punA - 2.4.2.1,2.4.2.28 ko:K00772,ko:K03783 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 HSJS3_k127_3123862_34 1169144.KB910924_gene461 2.606e-07 61.0 COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,4HG80@91061|Bacilli,1ZFNB@1386|Bacillus 91061|Bacilli D Cell division initiation protein divIVA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA HSJS3_k127_3123862_22 383372.Rcas_3740 2.01e-47 179.0 COG0325@1|root,COG0325@2|Bacteria,2G6F1@200795|Chloroflexi,375I2@32061|Chloroflexia 32061|Chloroflexia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N HSJS3_k127_3123862_31 29581.BW37_00070 6.319e-12 74.0 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VWQ1@28216|Betaproteobacteria,478R2@75682|Oxalobacteraceae 28216|Betaproteobacteria M Gram-negative bacterial TonB protein C-terminal tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C HSJS3_k127_3123862_30 880073.Calab_2425 2.195e-12 73.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD HSJS3_k127_3123862_29 880073.Calab_2425 6.177e-19 91.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD HSJS3_k127_3123862_23 945713.IALB_1535 2.197e-40 158.0 COG0811@1|root,COG0811@2|Bacteria 2|Bacteria U bacteriocin transport exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB HSJS3_k127_3123862_13 861299.J421_3044 1.877e-71 250.0 COG1624@1|root,COG1624@2|Bacteria,1ZUI8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N HSJS3_k127_3123862_12 269799.Gmet_1889 3.074e-74 261.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,43T3H@69541|Desulfuromonadales 28221|Deltaproteobacteria H Pterin binding enzyme folP - 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind HSJS3_k127_3123862_0 861299.J421_3042 4.66e-259 815.0 COG0465@1|root,COG0465@2|Bacteria,1ZSRI@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,Peptidase_M41 HSJS3_k127_3123862_14 379066.GAU_1392 6.76e-68 235.0 COG0634@1|root,COG0634@2|Bacteria,1ZTH7@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Phosphoribosyl transferase domain - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran HSJS3_k127_3123862_21 717605.Theco_3684 8.531e-48 190.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,4H9ZM@91061|Bacilli,26S70@186822|Paenibacillaceae 91061|Bacilli D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 2.4.2.8,6.3.4.19 ko:K04075,ko:K15780 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01132,R01229,R02142,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C HSJS3_k127_3123862_20 1125863.JAFN01000001_gene967 1.9e-49 184.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF HSJS3_k127_3123862_6 1379270.AUXF01000006_gene121 3.099e-96 320.0 COG0528@1|root,COG0528@2|Bacteria,1ZSY2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase HSJS3_k127_3123862_16 1460635.JCM19038_1287 2.926e-64 229.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli 91061|Bacilli J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS HSJS3_k127_3123862_7 1379270.AUXF01000006_gene119 2e-93 317.0 COG0052@1|root,COG0052@2|Bacteria,1ZSNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S2 rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 HSJS3_k127_3123862_24 1379270.AUXF01000006_gene118 3.341e-35 140.0 COG0103@1|root,COG0103@2|Bacteria,1ZTM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Ribosomal protein S9/S16 rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 HSJS3_k127_3123862_19 1401067.HMPREF0872_06525 2.076e-56 200.0 COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,4H3ZK@909932|Negativicutes 909932|Negativicutes J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 HSJS3_k127_3123862_18 1379270.AUXF01000005_gene483 2.799e-63 228.0 COG0568@1|root,COG0568@2|Bacteria,1ZSR6@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 HSJS3_k127_3123862_11 861299.J421_2921 5.965e-77 266.0 COG0681@1|root,COG0681@2|Bacteria,1ZTQ3@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 HSJS3_k127_3123862_26 521674.Plim_2408 1.317e-29 128.0 COG0720@1|root,COG0720@2|Bacteria,2IZMP@203682|Planctomycetes 203682|Planctomycetes H COG0720 6-pyruvoyl-tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS HSJS3_k127_3123862_3 1120792.JAFV01000001_gene2309 6.324e-110 373.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria,36XM8@31993|Methylocystaceae 28211|Alphaproteobacteria EH Anthranilate synthase component I, N terminal region pabB - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind HSJS3_k127_3123862_17 634177.GLX_07600 2.164e-63 225.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria,2JRWU@204441|Rhodospirillales 204441|Rhodospirillales EH COG0512 Anthranilate para-aminobenzoate synthases component II trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase HSJS3_k127_3123862_2 1120973.AQXL01000128_gene2874 2.423e-123 412.0 COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,4HBSG@91061|Bacilli,2788N@186823|Alicyclobacillaceae 91061|Bacilli O Magnesium chelatase, subunit ChlI C-terminal comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C HSJS3_k127_3123862_8 1121930.AQXG01000005_gene597 9.397e-85 287.0 COG0778@1|root,COG0778@2|Bacteria,4NFJK@976|Bacteroidetes,1IUKS@117747|Sphingobacteriia 976|Bacteroidetes C Nitroreductase family - - - - - - - - - - - - Nitroreductase HSJS3_k127_3123862_28 573370.DMR_45540 2.054e-19 100.0 COG0697@1|root,COG0697@2|Bacteria,1N8TG@1224|Proteobacteria,42W8X@68525|delta/epsilon subdivisions,2WSB5@28221|Deltaproteobacteria,2MGJ5@213115|Desulfovibrionales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA HSJS3_k127_3123862_25 861299.J421_2906 4.624e-32 132.0 COG1402@1|root,COG1402@2|Bacteria 2|Bacteria I creatininase - - 3.5.2.10 ko:K01470,ko:K22232 ko00330,ko00562,map00330,map00562 - R01884,R11771 RC00615 ko00000,ko00001,ko01000 - - - Creatininase HSJS3_k127_3123862_33 379066.GAU_1149 6.042e-08 63.0 2FH8I@1|root,3492W@2|Bacteria,1ZTXF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3123862_32 880073.Calab_1159 3.317e-10 69.0 2A6YD@1|root,30VTC@2|Bacteria,2NQ0X@2323|unclassified Bacteria 2|Bacteria S Yip1 domain - - - - - - - - - - - - Yip1 HSJS3_k127_3123862_4 861299.J421_2903 2.055e-100 342.0 COG0845@1|root,COG0845@2|Bacteria,1ZSX4@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 HSJS3_k127_3123862_5 379066.GAU_1146 4.191e-100 331.0 COG1136@1|root,COG1136@2|Bacteria,1ZSKH@142182|Gemmatimonadetes 142182|Gemmatimonadetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran HSJS3_k127_3123862_9 379066.GAU_1141 6.595e-83 290.0 COG0577@1|root,COG0577@2|Bacteria,1ZUMY@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD HSJS3_k127_3123862_10 861299.J421_2900 4.906e-81 286.0 COG0577@1|root,COG0577@2|Bacteria,1ZUN6@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD HSJS3_k127_3123862_15 298653.Franean1_1079 1.741e-65 233.0 COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4ERR3@85013|Frankiales 201174|Actinobacteria E PFAM aminotransferase class V iscS GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 HSJS3_k127_3210983_9 379066.GAU_2512 9.081e-06 50.0 COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt HSJS3_k127_3210983_2 379066.GAU_2514 4.213e-103 357.0 COG4796@1|root,COG4796@2|Bacteria,1ZSRT@142182|Gemmatimonadetes 142182|Gemmatimonadetes U AMIN domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,Secretin,Secretin_N HSJS3_k127_3210983_6 379066.GAU_2515 2.734e-17 91.0 2F6AC@1|root,33YU1@2|Bacteria,1ZTY6@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3210983_8 1379698.RBG1_1C00001G1256 3.369e-07 62.0 COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria 2|Bacteria NU Pilus assembly protein, PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO HSJS3_k127_3210983_5 379066.GAU_2517 8.95e-18 92.0 COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Fimbrial assembly protein (PilN) - - - - - - - - - - - - PilN HSJS3_k127_3210983_1 861299.J421_3981 6.451e-108 361.0 COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 HSJS3_k127_3210983_10 1121403.AUCV01000042_gene138 0.0003357 53.0 COG4966@1|root,COG4966@2|Bacteria,1N2NR@1224|Proteobacteria,42TRJ@68525|delta/epsilon subdivisions,2WQQ2@28221|Deltaproteobacteria,2MKHU@213118|Desulfobacterales 28221|Deltaproteobacteria NU pilus assembly protein PilW - - - - - - - - - - - - N_methyl,PilW HSJS3_k127_3210983_11 1236542.BALM01000035_gene4226 0.0008164 48.0 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,2QC3C@267890|Shewanellaceae 1236|Gammaproteobacteria NU Type IV minor pilin ComP, DNA uptake sequence receptor pilE - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl HSJS3_k127_3210983_4 909663.KI867151_gene3116 1.287e-47 196.0 COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,42WPS@68525|delta/epsilon subdivisions,2WS8D@28221|Deltaproteobacteria,2MS9Z@213462|Syntrophobacterales 28221|Deltaproteobacteria S Bacterial membrane protein, YfhO - - - - - - - - - - - - YfhO HSJS3_k127_3210983_7 1379270.AUXF01000003_gene3388 7.805e-16 87.0 COG4968@1|root,COG4968@2|Bacteria,1ZUZK@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl HSJS3_k127_3210983_0 379066.GAU_2525 4.668e-173 556.0 COG2204@1|root,COG2204@2|Bacteria,1ZSRQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat HSJS3_k127_3210983_3 379066.GAU_2526 1.148e-53 201.0 COG3852@1|root,COG3852@2|Bacteria,1ZSYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA HSJS3_k127_3348936_0 1379698.RBG1_1C00001G1725 1.436e-280 892.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran HSJS3_k127_3348936_1 644966.Tmar_0783 8.018e-06 58.0 COG0419@1|root,COG0419@2|Bacteria,1UMHS@1239|Firmicutes,25GIK@186801|Clostridia,3WDIT@538999|Clostridiales incertae sedis 186801|Clostridia L AAA domain - - - - - - - - - - - - AAA_27 HSJS3_k127_3366865_1 749414.SBI_08504 1.139e-05 54.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria 201174|Actinobacteria U Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,Amidohydro_3,PD40,TAT_signal HSJS3_k127_3366865_0 717772.THIAE_03825 2.224e-09 70.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,45ZPB@72273|Thiotrichales 72273|Thiotrichales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N HSJS3_k127_3528517_0 47839.CCAU010000005_gene476 2.85e-82 282.0 COG0684@1|root,COG0684@2|Bacteria,2IH5H@201174|Actinobacteria,237HZ@1762|Mycobacteriaceae 201174|Actinobacteria H Aldolase/RraA - - - - - - - - - - - - RraA-like HSJS3_k127_3590024_46 546414.Deide_16480 2.04e-25 109.0 COG1335@1|root,COG1335@2|Bacteria 2|Bacteria Q hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase,MDMPI_N HSJS3_k127_3590024_26 370438.PTH_2721 6.048e-64 233.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM HSJS3_k127_3590024_56 634956.Geoth_1937 4.355e-10 67.0 COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,4HNX2@91061|Bacilli 91061|Bacilli CQ Ethanolamine utilization protein EutN pduN - - ko:K04028 - - - - ko00000 - - - EutN_CcmL HSJS3_k127_3590024_49 215803.DB30_2247 4.659e-20 98.0 COG4576@1|root,COG4576@2|Bacteria,1Q0YX@1224|Proteobacteria,434YC@68525|delta/epsilon subdivisions,2WZ99@28221|Deltaproteobacteria,2Z1MJ@29|Myxococcales 28221|Deltaproteobacteria CQ Ethanolamine utilisation protein EutN/carboxysome - - - - - - - - - - - - EutN_CcmL HSJS3_k127_3590024_41 1121472.AQWN01000001_gene63 1.952e-37 148.0 COG4577@1|root,COG4577@2|Bacteria,1UKDS@1239|Firmicutes,24IS5@186801|Clostridia,261TI@186807|Peptococcaceae 186801|Clostridia CQ Carbon dioxide concentrating mechanism carboxysome shell protein csoS1C - - - - - - - - - - - BMC HSJS3_k127_3590024_6 1131730.BAVI_09041 1.795e-138 456.0 COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,4IS6J@91061|Bacilli,1ZSC0@1386|Bacillus 91061|Bacilli C Aldehyde dehydrogenase family acdH - 1.1.1.1,1.2.1.10,1.2.1.87 ko:K04072,ko:K13922 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00640,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927,R09097 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh HSJS3_k127_3590024_44 502025.Hoch_5814 3.537e-30 122.0 COG4576@1|root,COG4576@2|Bacteria,1RIK4@1224|Proteobacteria,4362N@68525|delta/epsilon subdivisions,2X9F2@28221|Deltaproteobacteria,2Z246@29|Myxococcales 28221|Deltaproteobacteria CQ Ethanolamine utilisation protein EutN/carboxysome - - - - - - - - - - - - EutN_CcmL HSJS3_k127_3590024_43 1499967.BAYZ01000012_gene2485 1.862e-36 140.0 COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria 2|Bacteria CQ COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein - - - ko:K04027 - - - - ko00000 - - - BMC HSJS3_k127_3590024_13 56110.Oscil6304_5272 4.017e-94 312.0 COG4577@1|root,COG4577@2|Bacteria,1G0GA@1117|Cyanobacteria,1H73J@1150|Oscillatoriales 1117|Cyanobacteria CQ PFAM BMC domain - - - - - - - - - - - - BMC HSJS3_k127_3590024_19 218284.CCDN010000001_gene740 3.192e-76 269.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,1ZCZ6@1386|Bacillus 91061|Bacilli F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC HSJS3_k127_3590024_36 234267.Acid_2204 4.814e-44 170.0 COG0698@1|root,COG0698@2|Bacteria 2|Bacteria G galactose-6-phosphate isomerase activity upp - 2.4.2.9,5.3.1.6 ko:K00761,ko:K01808 ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R00966,R01056,R09030 RC00063,RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB,UPRTase HSJS3_k127_3590024_39 314225.ELI_11015 6.632e-41 159.0 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2U0G2@28211|Alphaproteobacteria,2K7V1@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial transcriptional repressor C-terminal - - - - - - - - - - - - TetR_C_13,TetR_N HSJS3_k127_3590024_23 1121033.AUCF01000046_gene548 6.108e-67 241.0 COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,2JSK7@204441|Rhodospirillales 204441|Rhodospirillales S SOS response associated peptidase (SRAP) - - - - - - - - - - - - SRAP HSJS3_k127_3590024_34 945713.IALB_2287 3.804e-50 186.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_3590024_58 1255043.TVNIR_0147 2.371e-08 60.0 COG5662@1|root,COG5662@2|Bacteria 2|Bacteria K AntiSigma factor rsrA GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - - - - - - - - - - zf-HC2 HSJS3_k127_3590024_11 266117.Rxyl_0738 9.877e-108 359.0 COG1363@1|root,COG1363@2|Bacteria,2ID5X@201174|Actinobacteria,4CP5U@84995|Rubrobacteria 84995|Rubrobacteria G peptidase M42 - - - - - - - - - - - - Peptidase_M42 HSJS3_k127_3590024_29 379066.GAU_2712 1.203e-58 211.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1ZTHJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress,FeoA HSJS3_k127_3590024_32 861299.J421_3592 5.711e-56 206.0 COG0613@1|root,COG0613@2|Bacteria,1ZTHM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP HSJS3_k127_3590024_7 237368.SCABRO_02752 2.959e-131 428.0 COG0492@1|root,COG0492@2|Bacteria,2IX3E@203682|Planctomycetes 203682|Planctomycetes C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 HSJS3_k127_3590024_42 1379270.AUXF01000003_gene3855 1.724e-36 141.0 COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn HSJS3_k127_3590024_33 1125863.JAFN01000001_gene1846 8.649e-52 194.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WN14@28221|Deltaproteobacteria 28221|Deltaproteobacteria S beta-lactamase domain protein ycbL - - - - - - - - - - - Lactamase_B HSJS3_k127_3590024_25 1121918.ARWE01000001_gene1204 1.942e-65 240.0 COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,43SCM@69541|Desulfuromonadales 28221|Deltaproteobacteria S DHH family - - - - - - - - - - - - DHH,DHHA1 HSJS3_k127_3590024_37 1120950.KB892707_gene5009 6.356e-42 173.0 COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4DQNK@85009|Propionibacteriales 201174|Actinobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE,GrpB HSJS3_k127_3590024_45 1220534.B655_0123 4.848e-26 124.0 COG0613@1|root,arCOG00302@2157|Archaea,2XT0K@28890|Euryarchaeota 28890|Euryarchaeota S PHP domain protein - - - - - - - - - - - - PHP,PHP_C HSJS3_k127_3590024_24 861299.J421_3916 1.197e-66 241.0 COG0618@1|root,COG0618@2|Bacteria,1ZSS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 HSJS3_k127_3590024_20 379066.GAU_0930 6.971e-76 261.0 COG0785@1|root,COG0785@2|Bacteria,1ZTJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Cytochrome C biogenesis protein transmembrane region - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD HSJS3_k127_3590024_4 379066.GAU_0931 5.763e-171 555.0 COG1132@1|root,COG1132@2|Bacteria,1ZT5Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes P ABC transporter transmembrane region - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran HSJS3_k127_3590024_57 204669.Acid345_4293 5.076e-09 68.0 COG2823@1|root,COG2823@2|Bacteria,3Y99E@57723|Acidobacteria,2JP08@204432|Acidobacteriia 204432|Acidobacteriia S Periplasmic or secreted lipoprotein - - - - - - - - - - - - - HSJS3_k127_3590024_5 448385.sce8554 1.192e-161 532.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YU0V@29|Myxococcales 28221|Deltaproteobacteria M gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept HSJS3_k127_3590024_17 1128421.JAGA01000001_gene2309 5.76e-81 283.0 COG2377@1|root,COG2377@2|Bacteria,2NNMN@2323|unclassified Bacteria 2|Bacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170,4.2.1.126 ko:K07106,ko:K09001 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 AnmK HSJS3_k127_3590024_28 1379270.AUXF01000004_gene2957 1.437e-59 228.0 COG1472@1|root,COG1472@2|Bacteria,1ZST8@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3 HSJS3_k127_3590024_2 1089550.ATTH01000001_gene1273 8.013e-230 726.0 COG0591@1|root,COG0591@2|Bacteria,4PKHI@976|Bacteroidetes,1FIMH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF HSJS3_k127_3590024_16 1379270.AUXF01000004_gene2955 3.09e-88 315.0 COG0860@1|root,COG0860@2|Bacteria,1ZT6J@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Ami_3 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 HSJS3_k127_3590024_35 159087.Daro_2740 5.73e-48 183.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,2KW50@206389|Rhodocyclales 206389|Rhodocyclales S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep HSJS3_k127_3590024_0 861299.J421_2847 0.0 1084.0 COG0209@1|root,COG0209@2|Bacteria,1ZSU9@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN HSJS3_k127_3590024_53 1192034.CAP_4691 4.491e-15 85.0 COG3137@1|root,COG3137@2|Bacteria,1N2DE@1224|Proteobacteria,42W9S@68525|delta/epsilon subdivisions,2WTC1@28221|Deltaproteobacteria,2YVUC@29|Myxococcales 28221|Deltaproteobacteria M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 HSJS3_k127_3590024_15 1121899.Q764_00465 8.624e-91 308.0 COG1878@1|root,COG1878@2|Bacteria,4NFYB@976|Bacteroidetes,1IIVK@117743|Flavobacteriia,2P0GH@237|Flavobacterium 976|Bacteroidetes S Putative cyclase - - - - - - - - - - - - Cyclase HSJS3_k127_3590024_40 1123242.JH636436_gene744 1.345e-39 153.0 COG2318@1|root,COG2318@2|Bacteria,2IZP2@203682|Planctomycetes 203682|Planctomycetes S DinB family - - - - - - - - - - - - DinB,DinB_2 HSJS3_k127_3590024_18 309807.SRU_0328 8.951e-78 267.0 COG0428@1|root,COG0428@2|Bacteria,4PF37@976|Bacteroidetes,1FK2I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P ZIP Zinc transporter - - - - - - - - - - - - Zip HSJS3_k127_3590024_38 1122176.KB903569_gene3490 6.997e-42 163.0 2DEWU@1|root,2ZPJP@2|Bacteria,4NPJW@976|Bacteroidetes,1ITQ6@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_3590024_3 867903.ThesuDRAFT_00242 1.287e-181 578.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3WCC9@538999|Clostridiales incertae sedis 186801|Clostridia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430 GcpE HSJS3_k127_3590024_54 471855.Shel_05440 6.176e-15 86.0 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4CUVN@84998|Coriobacteriia 84998|Coriobacteriia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B HSJS3_k127_3590024_50 394221.Mmar10_0412 2.113e-18 96.0 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,2U9QU@28211|Alphaproteobacteria,43YB6@69657|Hyphomonadaceae 28211|Alphaproteobacteria EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 HSJS3_k127_3590024_59 525904.Tter_1056 4.452e-08 56.0 COG0828@1|root,COG0828@2|Bacteria,2NQ1U@2323|unclassified Bacteria 2|Bacteria J Ribosomal protein S21 rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 HSJS3_k127_3590024_52 580331.Thit_1530 6.559e-16 81.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,42H4W@68295|Thermoanaerobacterales 186801|Clostridia K Cold shock protein cspB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD HSJS3_k127_3590024_8 861299.J421_2871 4.283e-129 435.0 COG0469@1|root,COG0469@2|Bacteria,1ZSMD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Pyruvate kinase, barrel domain - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C HSJS3_k127_3590024_21 861299.J421_2872 1.945e-74 260.0 COG1235@1|root,COG1235@2|Bacteria,1ZT49@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 HSJS3_k127_3590024_1 861299.J421_3751 8.289e-272 848.0 COG0481@1|root,COG0481@2|Bacteria,1ZTGT@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,LepA_C HSJS3_k127_3590024_9 861299.J421_3753 2.533e-124 406.0 COG1940@1|root,COG1940@2|Bacteria,1ZT66@142182|Gemmatimonadetes 142182|Gemmatimonadetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK HSJS3_k127_3590024_27 1379270.AUXF01000003_gene3691 7.649e-60 219.0 COG0524@1|root,COG0524@2|Bacteria,1ZTFD@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - - - - - - - - - - - HSJS3_k127_3590024_22 861299.J421_3755 1.658e-69 254.0 COG0643@1|root,COG0643@2|Bacteria,1ZSPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes NT Histidine kinase-like ATPases - - - - - - - - - - - - - HSJS3_k127_3590024_47 861299.J421_3756 1.471e-23 108.0 2EFCU@1|root,3395Q@2|Bacteria,1ZTVZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3590024_10 1089552.KI911559_gene2415 4.095e-108 381.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2JPKU@204441|Rhodospirillales 204441|Rhodospirillales S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase HSJS3_k127_3590024_51 1120973.AQXL01000135_gene1336 2.907e-16 82.0 COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,4HKQ8@91061|Bacilli,278KT@186823|Alicyclobacillaceae 91061|Bacilli O NifU-like domain yutI - - - - - - - - - - - NifU HSJS3_k127_3590024_14 1379270.AUXF01000003_gene3479 2.34e-93 319.0 COG0489@1|root,COG0489@2|Bacteria,1ZSW7@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA HSJS3_k127_3590024_12 861299.J421_3914 2.311e-101 347.0 COG0534@1|root,COG0534@2|Bacteria,1ZTFM@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE HSJS3_k127_3590024_31 82654.Pse7367_1008 3.955e-56 207.0 COG1912@1|root,COG1912@2|Bacteria,1G1B1@1117|Cyanobacteria,1H78G@1150|Oscillatoriales 1117|Cyanobacteria S PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans HSJS3_k127_3590024_48 517418.Ctha_2497 2.375e-22 108.0 2DU1M@1|root,33NIU@2|Bacteria,1FFDR@1090|Chlorobi 1090|Chlorobi - - - - - - - - - - - - - - - HSJS3_k127_3590024_55 861299.J421_3910 2.978e-12 79.0 COG1664@1|root,COG1664@2|Bacteria 2|Bacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin HSJS3_k127_3590024_60 1379270.AUXF01000003_gene3483 3.662e-06 56.0 2F9A9@1|root,341MC@2|Bacteria,1ZU0R@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3590024_30 379066.GAU_2442 2.734e-58 207.0 COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_3634779_15 861299.J421_2430 0.00014 49.0 298DU@1|root,2ZVJ1@2|Bacteria,1ZU76@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3634779_11 861299.J421_2432 1.072e-29 124.0 COG1595@1|root,COG1595@2|Bacteria,1ZT0A@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_3634779_6 880073.Calab_1575 4.848e-73 253.0 COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria 2|Bacteria C Electron transfer flavoprotein etfB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF HSJS3_k127_3634779_4 861299.J421_3930 2.781e-82 290.0 COG2025@1|root,COG2025@2|Bacteria,1ZTDU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Electron transfer flavoprotein domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha HSJS3_k127_3634779_8 1120919.AUBI01000006_gene700 1.237e-52 198.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,2JRYH@204441|Rhodospirillales 204441|Rhodospirillales O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI HSJS3_k127_3634779_13 1192868.CAIU01000028_gene3726 2.482e-16 89.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,43J0S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H Probable molybdopterin binding domain MA20_09420 - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - MoCF_biosynth,NTP_transf_3 HSJS3_k127_3634779_2 1379270.AUXF01000004_gene3068 1.195e-95 326.0 COG1131@1|root,COG1131@2|Bacteria,1ZUPB@142182|Gemmatimonadetes 142182|Gemmatimonadetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran HSJS3_k127_3634779_0 1379270.AUXF01000004_gene3069 3.938e-121 411.0 28M0D@1|root,2ZAFE@2|Bacteria,1ZUP5@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative ATP-binding cassette - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 HSJS3_k127_3634779_7 1238182.C882_0401 8.041e-66 238.0 COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VFY5@28211|Alphaproteobacteria,2JRKP@204441|Rhodospirillales 204441|Rhodospirillales E Putative serine dehydratase domain - - - - - - - - - - - - Ala_racemase_N,D-ser_dehydrat HSJS3_k127_3634779_10 379066.GAU_0474 1.577e-44 170.0 COG1595@1|root,COG1595@2|Bacteria,1ZSWF@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_3634779_12 941449.dsx2_0326 1.083e-20 101.0 COG0296@1|root,COG0296@2|Bacteria,1NEFK@1224|Proteobacteria,42VRH@68525|delta/epsilon subdivisions,2WRD5@28221|Deltaproteobacteria,2MC6U@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM glycoside hydrolase family 13 domain protein - - - - - - - - - - - - AMPK1_CBM HSJS3_k127_3634779_14 861299.J421_1305 3.793e-13 78.0 28YSJ@1|root,343H2@2|Bacteria,1ZU2N@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3634779_9 644966.Tmar_0947 2.139e-51 197.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WCVT@538999|Clostridiales incertae sedis 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C HSJS3_k127_3634779_1 187272.Mlg_1158 5.648e-109 372.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,1RQ15@1236|Gammaproteobacteria,1X0JQ@135613|Chromatiales 135613|Chromatiales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - HSJS3_k127_3634779_3 861299.J421_3927 5.88e-94 327.0 COG0303@1|root,COG0303@2|Bacteria,1ZT4D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N HSJS3_k127_3634779_5 65497.JODV01000008_gene172 2.609e-78 280.0 COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4DY4W@85010|Pseudonocardiales 201174|Actinobacteria M D-Ala-D-Ala carboxypeptidase 3 (S13) family - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 HSJS3_k127_3659447_22 159087.Daro_1922 2.762e-35 139.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2VICH@28216|Betaproteobacteria,2KV0H@206389|Rhodocyclales 206389|Rhodocyclales F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N HSJS3_k127_3659447_41 1379270.AUXF01000004_gene3073 6.315e-06 55.0 29W2Z@1|root,30HMM@2|Bacteria,1ZTXQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3659447_12 251221.35213046 3.636e-93 317.0 COG2008@1|root,COG2008@2|Bacteria,1G4PN@1117|Cyanobacteria 1117|Cyanobacteria E Threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase HSJS3_k127_3659447_30 1120956.JHZK01000030_gene13 3.274e-24 105.0 COG3360@1|root,COG3360@2|Bacteria 2|Bacteria P Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin HSJS3_k127_3659447_0 344747.PM8797T_07207 2.27e-243 777.0 COG0433@1|root,COG0433@2|Bacteria,2IY71@203682|Planctomycetes 203682|Planctomycetes L AAA-like domain - - - - - - - - - - - - DUF853,DUF87,PDDEXK_1 HSJS3_k127_3659447_5 1385520.N802_00860 5.126e-149 481.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4FFS1@85021|Intrasporangiaceae 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA HSJS3_k127_3659447_35 1121365.AQXB01000001_gene874 4.966e-17 90.0 COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,22MP4@1653|Corynebacteriaceae 201174|Actinobacteria S Modulates RecA activity recX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03565 - - - - ko00000,ko03400 - - - RecX HSJS3_k127_3659447_1 867903.ThesuDRAFT_00022 7.74e-243 778.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3WCF6@538999|Clostridiales incertae sedis 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD HSJS3_k127_3659447_25 861299.J421_3520 3.48e-32 138.0 COG4464@1|root,COG4464@2|Bacteria,1ZTQH@142182|Gemmatimonadetes 142182|Gemmatimonadetes GM protein tyrosine phosphatase activity - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - - HSJS3_k127_3659447_13 861299.J421_3513 2.891e-88 310.0 COG0617@1|root,COG0617@2|Bacteria,1ZSKW@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Probable RNA and SrmB- binding site of polymerase A - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 HSJS3_k127_3659447_6 861299.J421_3506 7.886e-131 431.0 COG2262@1|root,COG2262@2|Bacteria,1ZSYM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 HSJS3_k127_3659447_14 1158318.ATXC01000001_gene465 2.382e-84 286.0 COG0854@1|root,COG0854@2|Bacteria,2G3M8@200783|Aquificae 200783|Aquificae H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ HSJS3_k127_3659447_16 379066.GAU_1245 2.11e-56 212.0 COG0392@1|root,COG0392@2|Bacteria,1ZT5W@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM HSJS3_k127_3659447_18 643648.Slip_0101 4.069e-40 165.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,42JVK@68298|Syntrophomonadaceae 186801|Clostridia F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N HSJS3_k127_3659447_3 518766.Rmar_1111 2.27e-205 660.0 COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1FIJF@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH HSJS3_k127_3659447_7 379066.GAU_1219 6.894e-125 407.0 COG0462@1|root,COG0462@2|Bacteria,1ZT7Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N HSJS3_k127_3659447_20 1379270.AUXF01000005_gene525 2.075e-39 155.0 COG1825@1|root,COG1825@2|Bacteria,1ZTHZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance - - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C HSJS3_k127_3659447_19 1379270.AUXF01000005_gene524 1.183e-39 156.0 COG0193@1|root,COG0193@2|Bacteria,1ZTKT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro HSJS3_k127_3659447_2 56780.SYN_02772 1.138e-221 706.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2MQUH@213462|Syntrophobacterales 28221|Deltaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase HSJS3_k127_3659447_34 861299.J421_2953 1.912e-18 91.0 COG0360@1|root,COG0360@2|Bacteria,1ZTYY@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 HSJS3_k127_3659447_31 697329.Rumal_2478 2.201e-21 94.0 COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,3WJU7@541000|Ruminococcaceae 186801|Clostridia J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 HSJS3_k127_3659447_38 861299.J421_2951 1.149e-13 82.0 2F1RZ@1|root,33US3@2|Bacteria,1ZUSC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - DUF2232 HSJS3_k127_3659447_24 338963.Pcar_1996 6.268e-33 132.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,43SJQ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ribosomal protein L9, N-terminal domain rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N HSJS3_k127_3659447_11 882.DVU_1942 3.619e-94 331.0 COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,42U2G@68525|delta/epsilon subdivisions,2WQBG@28221|Deltaproteobacteria,2M8TG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Dihydroxyacetone kinase family - - - ko:K07030 - - - - ko00000 - - - Dak2,DegV HSJS3_k127_3659447_28 1123253.AUBD01000007_gene682 8.732e-26 110.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1X6H0@135614|Xanthomonadales 135614|Xanthomonadales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS HSJS3_k127_3659447_37 861299.J421_2947 8.536e-14 85.0 COG3087@1|root,COG3087@2|Bacteria,1ZSYS@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Sporulation related domain - - - - - - - - - - - - SPOR HSJS3_k127_3659447_40 240302.BN982_01686 6.194e-07 62.0 COG0860@1|root,COG3087@1|root,COG0860@2|Bacteria,COG3087@2|Bacteria,1TWQM@1239|Firmicutes,4HC00@91061|Bacilli,3NFR3@45667|Halobacillus 91061|Bacilli DM Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - - - - - - - - - - Amidase_3,Glucosaminidase,SPOR HSJS3_k127_3659447_4 861299.J421_2945 4.214e-191 640.0 COG1196@1|root,COG1196@2|Bacteria,1ZSY1@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge HSJS3_k127_3659447_17 1379270.AUXF01000005_gene503 1.032e-52 199.0 COG1234@1|root,COG1234@2|Bacteria,1ZT5E@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 HSJS3_k127_3659447_33 1268303.RHODMAR_3514 1.495e-19 93.0 COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4G1R8@85025|Nocardiaceae 201174|Actinobacteria L Belongs to the UPF0102 family yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 HSJS3_k127_3659447_10 861299.J421_2881 9.738e-112 380.0 COG2812@1|root,COG2812@2|Bacteria,1ZTFV@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 HSJS3_k127_3659447_39 862517.HMPREF9225_1808 5.835e-09 61.0 COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,22HRF@1570339|Peptoniphilaceae 186801|Clostridia L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd HSJS3_k127_3659447_15 1379270.AUXF01000005_gene387 2.233e-68 238.0 COG0353@1|root,COG0353@2|Bacteria,1ZTJX@142182|Gemmatimonadetes 142182|Gemmatimonadetes L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 HSJS3_k127_3659447_32 1379270.AUXF01000005_gene388 2.99e-21 96.0 29142@1|root,2ZNRG@2|Bacteria,1ZV6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_3659447_26 1540221.JQNI01000002_gene2879 4.539e-31 129.0 COG1100@1|root,COG1100@2|Bacteria,1WJAD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM ADP-ribosylation factor family - - - ko:K06883 - - - - ko00000 - - - Arf HSJS3_k127_3659447_23 1379270.AUXF01000005_gene391 5.416e-34 141.0 COG0558@1|root,COG0558@2|Bacteria,1ZSXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf HSJS3_k127_3659447_21 391625.PPSIR1_39025 1.375e-35 143.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2YUQX@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth HSJS3_k127_3659447_27 1120973.AQXL01000116_gene322 8.313e-31 137.0 COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,4HEHP@91061|Bacilli,2797U@186823|Alicyclobacillaceae 91061|Bacilli I Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 HSJS3_k127_3659447_29 861299.J421_2889 1.781e-24 110.0 COG0576@1|root,COG0576@2|Bacteria,1ZTSJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE HSJS3_k127_3659447_8 1379270.AUXF01000005_gene395 2.217e-116 385.0 COG0484@1|root,COG0484@2|Bacteria,1ZT5T@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG HSJS3_k127_3659447_9 379066.GAU_1130 5.916e-112 375.0 COG0482@1|root,COG0482@2|Bacteria,1ZST7@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans HSJS3_k127_3659447_36 1122963.AUHB01000015_gene4437 5.36e-16 83.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,36Y05@31993|Methylocystaceae 28211|Alphaproteobacteria E Aminotransferase class-V nifS GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 HSJS3_k127_3959450_10 391008.Smal_0840 2.075e-15 84.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1X4BU@135614|Xanthomonadales 135614|Xanthomonadales O peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 HSJS3_k127_3959450_4 861299.J421_3744 1.221e-69 254.0 COG1995@1|root,COG1995@2|Bacteria,1ZT2S@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyridoxal phosphate biosynthetic protein PdxA - - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA HSJS3_k127_3959450_3 379066.GAU_2160 8.36e-73 252.0 COG2884@1|root,COG2884@2|Bacteria,1ZTHQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes D ABC transporter - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran HSJS3_k127_3959450_8 861299.J421_3760 2.507e-49 188.0 COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Part of the ABC transporter FtsEX involved in - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - HSJS3_k127_3959450_5 1379270.AUXF01000003_gene3684 8.557e-59 219.0 COG4942@1|root,COG4942@2|Bacteria,1ZSU6@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 HSJS3_k127_3959450_6 861299.J421_3797 1.017e-55 210.0 COG0470@1|root,COG0470@2|Bacteria,1ZT21@142182|Gemmatimonadetes 142182|Gemmatimonadetes L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 HSJS3_k127_3959450_7 566466.NOR53_2262 1.883e-49 182.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1J7VU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoaC HSJS3_k127_3959450_9 861299.J421_3799 7.169e-33 134.0 COG0741@1|root,COG0741@2|Bacteria,1ZTV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase SLT domain - - - - - - - - - - - - SLT HSJS3_k127_3959450_0 861299.J421_3569 6.756e-165 529.0 COG0677@1|root,COG0677@2|Bacteria,1ZT42@142182|Gemmatimonadetes 142182|Gemmatimonadetes M UDP binding domain - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N HSJS3_k127_3959450_2 644282.Deba_0596 4.7e-86 303.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lytic transglycosylase catalytic mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT HSJS3_k127_3959450_1 1246484.D479_09467 2.935e-87 292.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,4H9V3@91061|Bacilli,3NEES@45667|Halobacillus 91061|Bacilli F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH HSJS3_k127_404272_11 760568.Desku_3528 8.117e-88 292.0 COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,24863@186801|Clostridia,263QH@186807|Peptococcaceae 186801|Clostridia M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd HSJS3_k127_404272_6 1476583.DEIPH_ctg026orf0054 3.346e-138 463.0 COG0399@1|root,COG0399@2|Bacteria,1WJBP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - - - - - - - - - - DegT_DnrJ_EryC1 HSJS3_k127_404272_17 861299.J421_4163 8.724e-72 256.0 COG0795@1|root,COG0795@2|Bacteria,1ZSNM@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Predicted permease YjgP/YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ HSJS3_k127_404272_19 1379698.RBG1_1C00001G1858 4.063e-67 255.0 COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ family protein lptF GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K07091,ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - iECED1_1282.ECED1_5114,iUMNK88_1353.UMNK88_5207 YjgP_YjgQ HSJS3_k127_404272_9 1142394.PSMK_14960 6.529e-96 334.0 COG1519@1|root,COG1519@2|Bacteria,2IYCJ@203682|Planctomycetes 203682|Planctomycetes M transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N HSJS3_k127_404272_27 1234364.AMSF01000037_gene145 1.437e-37 145.0 COG0859@1|root,COG0859@2|Bacteria,1MZGQ@1224|Proteobacteria,1S7TT@1236|Gammaproteobacteria,1X6DP@135614|Xanthomonadales 135614|Xanthomonadales M PFAM glycosyl transferase family 9 - - - - - - - - - - - - - HSJS3_k127_404272_13 1116369.KB890024_gene3198 3.526e-85 297.0 COG0438@1|root,COG0438@2|Bacteria,1N01H@1224|Proteobacteria,2UNWG@28211|Alphaproteobacteria,43I22@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 HSJS3_k127_404272_3 379066.GAU_0638 1.278e-162 527.0 COG0745@1|root,COG0745@2|Bacteria,1ZTEW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT PglZ domain - - - - - - - - - - - - PglZ,Response_reg HSJS3_k127_404272_5 861299.J421_2583 6.821e-144 482.0 COG1132@1|root,COG1132@2|Bacteria,1ZT2T@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran HSJS3_k127_404272_31 221288.JH992901_gene3386 6.697e-16 90.0 COG0438@1|root,COG0438@2|Bacteria,1G27U@1117|Cyanobacteria 1117|Cyanobacteria M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 HSJS3_k127_404272_23 861299.J421_2674 1.824e-49 184.0 COG0463@1|root,COG0463@2|Bacteria,1ZTJE@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyl transferase family 2 - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - Glycos_transf_2 HSJS3_k127_404272_24 1379270.AUXF01000005_gene516 4.517e-48 188.0 COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 HSJS3_k127_404272_33 861299.J421_4201 1.968e-13 76.0 2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_404272_12 1538644.KO02_05025 1.171e-87 306.0 COG1253@1|root,COG1253@2|Bacteria,4NG0I@976|Bacteroidetes,1J08I@117747|Sphingobacteriia 976|Bacteroidetes S Transporter associated domain tlyC - - - - - - - - - - - CBS,CorC_HlyC,DUF21 HSJS3_k127_404272_21 861299.J421_4211 8.486e-66 239.0 COG0457@1|root,COG0457@2|Bacteria,1ZSYB@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2 HSJS3_k127_404272_39 351160.RCIX132 2.324e-06 57.0 arCOG01917@1|root,arCOG01917@2157|Archaea,2XYA0@28890|Euryarchaeota 28890|Euryarchaeota O SPFH domain-Band 7 family - - - - - - - - - - - - Band_7_1,DZR,zinc_ribbon_2 HSJS3_k127_404272_32 426117.M446_3645 5.946e-14 79.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,1JTMF@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - Cytochrome_CBB3,GSDH HSJS3_k127_404272_7 1183377.Py04_0852 2.787e-117 387.0 COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,242YH@183968|Thermococci 183968|Thermococci C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh HSJS3_k127_404272_4 404589.Anae109_0064 2.248e-147 477.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2Z30V@29|Myxococcales 28221|Deltaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K07508 ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00085,M00087,M00088,M00095,M00373,M00374,M00375 R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747 RC00004,RC00326,RC00405,RC01702 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N HSJS3_k127_404272_10 644282.Deba_1222 4.068e-91 310.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 HSJS3_k127_404272_30 379066.GAU_0464 6.763e-17 91.0 2FK9E@1|root,34BX2@2|Bacteria,1ZTYM@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_404272_8 204669.Acid345_1212 2.178e-108 358.0 COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria,2JI6S@204432|Acidobacteriia 57723|Acidobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N HSJS3_k127_404272_20 3075.A0A087SKQ3 6.331e-67 241.0 COG1063@1|root,KOG0024@2759|Eukaryota 2759|Eukaryota E L-arabinose catabolic process - - - - - - - - - - - - ADH_N,ADH_zinc_N HSJS3_k127_404272_14 861299.J421_2731 1.788e-80 282.0 COG1195@1|root,COG1195@2|Bacteria,1ZSRU@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N HSJS3_k127_404272_38 1125863.JAFN01000001_gene1680 2.64e-09 66.0 COG5512@1|root,COG5512@2|Bacteria,1N6KK@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 HSJS3_k127_404272_0 868595.Desca_0006 4.499e-271 849.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim HSJS3_k127_404272_15 663932.KB902575_gene405 1.026e-79 278.0 COG1351@1|root,COG1351@2|Bacteria,1MWY8@1224|Proteobacteria,2TTER@28211|Alphaproteobacteria,2JQGP@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 HSJS3_k127_404272_40 880073.Calab_2331 0.0001467 55.0 COG0457@1|root,COG0457@2|Bacteria 880073.Calab_2331|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - HSJS3_k127_404272_34 518766.Rmar_2301 5.831e-11 76.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - HSJS3_k127_404272_1 880073.Calab_0943 7.277e-211 683.0 COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469,ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV HSJS3_k127_404272_2 1379698.RBG1_1C00001G0312 3.858e-184 585.0 COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria 2|Bacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K02887,ko:K03628 ko03010,ko03018,map03010,map03018 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind HSJS3_k127_404272_37 1123277.KB893187_gene2726 7.44e-10 70.0 COG1463@1|root,COG1463@2|Bacteria,4NGHE@976|Bacteroidetes,47MRD@768503|Cytophagia 976|Bacteroidetes Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD HSJS3_k127_404272_16 1379270.AUXF01000007_gene1058 2.816e-79 272.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE HSJS3_k127_404272_18 379066.GAU_0711 1.741e-68 243.0 COG1127@1|root,COG1127@2|Bacteria,1ZT5N@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran HSJS3_k127_404272_25 1379270.AUXF01000007_gene1059 3.323e-41 166.0 COG1463@1|root,COG1463@2|Bacteria,1ZUJC@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD HSJS3_k127_404272_28 1313304.CALK_0345 3.326e-30 125.0 COG0629@1|root,COG0629@2|Bacteria 2|Bacteria L single-stranded DNA binding ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB HSJS3_k127_404272_26 1254432.SCE1572_14045 2.771e-40 162.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,42PP6@68525|delta/epsilon subdivisions,2WJN2@28221|Deltaproteobacteria 28221|Deltaproteobacteria GM PFAM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 HSJS3_k127_404272_36 479431.Namu_4015 6.868e-10 70.0 COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4ESIK@85013|Frankiales 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA2 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf HSJS3_k127_404272_22 1121033.AUCF01000010_gene4442 4.118e-62 229.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,2JQW0@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 HSJS3_k127_404272_35 402881.Plav_3444 1.676e-10 74.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TUFK@28211|Alphaproteobacteria,1JQJS@119043|Rhodobiaceae 28211|Alphaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP HSJS3_k127_404272_29 913865.DOT_2491 5.188e-21 94.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,263ZP@186807|Peptococcaceae 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran HSJS3_k127_4054173_0 1121924.ATWH01000003_gene1621 4.347e-119 405.0 COG1680@1|root,COG1680@2|Bacteria,2IG0Z@201174|Actinobacteria 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase HSJS3_k127_4054173_1 1379270.AUXF01000001_gene2436 4.563e-46 175.0 COG1595@1|root,COG1595@2|Bacteria,1ZV2D@142182|Gemmatimonadetes 142182|Gemmatimonadetes K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF HSJS3_k127_4159110_1 566466.NOR53_3413 1.31e-52 195.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_4159110_0 1280950.HJO_13121 4.9e-78 287.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C HSJS3_k127_4259135_1 1041146.ATZB01000009_gene3429 5.124e-36 147.0 COG5504@1|root,COG5504@2|Bacteria,1RG9M@1224|Proteobacteria,2UDBF@28211|Alphaproteobacteria,4BJEJ@82115|Rhizobiaceae 28211|Alphaproteobacteria O Predicted Zn-dependent protease (DUF2268) - - - - - - - - - - - - DUF2268 HSJS3_k127_4259135_0 1122604.JONR01000031_gene1279 6.752e-70 266.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 HSJS3_k127_4284009_4 1198452.Jab_2c15020 3.652e-25 119.0 COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,2VI30@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - 2CSK_N,HAMP,HATPase_c,HisKA HSJS3_k127_4284009_1 314345.SPV1_12687 1.195e-71 253.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria 1224|Proteobacteria KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C HSJS3_k127_4284009_2 1121918.ARWE01000001_gene1142 2.264e-40 162.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42URW@68525|delta/epsilon subdivisions,2WMYB@28221|Deltaproteobacteria,43SFS@69541|Desulfuromonadales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin HSJS3_k127_4284009_3 1437448.AZRT01000127_gene301 1.911e-33 137.0 COG3019@1|root,COG3019@2|Bacteria,1MZ9V@1224|Proteobacteria,2UC0B@28211|Alphaproteobacteria,1J42K@118882|Brucellaceae 28211|Alphaproteobacteria S Protein of unknown function, DUF - - - - - - - - - - - - DUF411 HSJS3_k127_4284009_0 1455608.JDTH01000011_gene2311 1.379e-185 591.0 COG0701@1|root,arCOG02712@2157|Archaea,2XU5I@28890|Euryarchaeota,23T00@183963|Halobacteria 183963|Halobacteria S metal ion permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1,YHS HSJS3_k127_4284009_5 382464.ABSI01000011_gene2355 3.488e-08 55.0 COG3544@1|root,COG3544@2|Bacteria,46W1K@74201|Verrucomicrobia 74201|Verrucomicrobia S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 HSJS3_k127_4317299_0 861299.J421_3856 1.369e-125 406.0 COG1219@1|root,COG1219@2|Bacteria,1ZT8F@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX HSJS3_k127_4317299_1 696281.Desru_1009 2.899e-41 160.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,261YZ@186807|Peptococcaceae 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 HSJS3_k127_4317299_2 861299.J421_3859 4.915e-25 117.0 2F4EZ@1|root,33X55@2|Bacteria,1ZTSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_4358072_15 1123368.AUIS01000002_gene1535 5.489e-24 111.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,2NCHN@225057|Acidithiobacillales 225057|Acidithiobacillales E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 HSJS3_k127_4358072_7 861299.J421_2752 3.377e-83 287.0 COG1760@1|root,COG1760@2|Bacteria,1ZT3U@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Serine dehydratase alpha chain - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha HSJS3_k127_4358072_8 861299.J421_2751 6.223e-62 226.0 COG1760@1|root,COG1760@2|Bacteria,1ZTFS@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Serine dehydratase beta chain - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - ACT,SDH_beta HSJS3_k127_4358072_10 861299.J421_2661 3.257e-57 207.0 COG0321@1|root,COG0321@2|Bacteria,1ZTM1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB HSJS3_k127_4358072_2 385682.AFSL01000009_gene2466 1.305e-136 449.0 COG1249@1|root,COG1249@2|Bacteria,4NDVC@976|Bacteroidetes,2FM8Y@200643|Bacteroidia,3XJAC@558415|Marinilabiliaceae 976|Bacteroidetes C L-lysine 6-monooxygenase (NADPH-requiring) lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim HSJS3_k127_4358072_3 379066.GAU_0748 2.955e-116 389.0 COG0508@1|root,COG0508@2|Bacteria,1ZSYJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding HSJS3_k127_4358072_1 861299.J421_2667 1.403e-137 445.0 COG0022@1|root,COG0022@2|Bacteria,1ZTA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C HSJS3_k127_4358072_5 861299.J421_2668 8.143e-108 361.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 142182|Gemmatimonadetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh HSJS3_k127_4358072_4 1379270.AUXF01000004_gene3127 3.914e-114 377.0 COG0320@1|root,COG0320@2|Bacteria,1ZTA3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM HSJS3_k127_4358072_13 383372.Rcas_0253 7.638e-35 136.0 COG1146@1|root,COG1146@2|Bacteria,2G75G@200795|Chloroflexi,375SD@32061|Chloroflexia 32061|Chloroflexia C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_4 HSJS3_k127_4358072_17 1048339.KB913029_gene4390 4.77e-10 71.0 COG3794@1|root,COG3794@2|Bacteria,2IR44@201174|Actinobacteria 201174|Actinobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - HSJS3_k127_4358072_18 634956.Geoth_1741 5.458e-06 52.0 2CICC@1|root,32S7S@2|Bacteria,1VC46@1239|Firmicutes,4HKPJ@91061|Bacilli,1WGP9@129337|Geobacillus 91061|Bacilli - - yneQ - - - - - - - - - - - - HSJS3_k127_4358072_9 1110502.TMO_0439 8.02e-61 217.0 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2TRGI@28211|Alphaproteobacteria,2JZRZ@204441|Rhodospirillales 204441|Rhodospirillales M OmpW family - - - ko:K07275 - - - - ko00000 - - - OmpW HSJS3_k127_4358072_0 379066.GAU_2797 3.483e-305 954.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C HSJS3_k127_4358072_6 1358423.N180_06535 1.501e-87 302.0 COG3488@1|root,COG3488@2|Bacteria,4NGBS@976|Bacteroidetes,1IWE8@117747|Sphingobacteriia 976|Bacteroidetes C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR HSJS3_k127_4358072_16 404589.Anae109_0582 1.589e-18 94.0 COG0723@1|root,COG0723@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on diphenols and related substances as donors - - - - - - - - - - - - Rieske HSJS3_k127_4358072_11 237368.SCABRO_00532 3.775e-50 196.0 COG1730@1|root,COG1730@2|Bacteria 2|Bacteria O sister chromatid segregation - - - - - - - - - - - - - HSJS3_k127_4358072_14 1267534.KB906758_gene2182 5.106e-25 111.0 2DEWU@1|root,2ZPJP@2|Bacteria,3Y585@57723|Acidobacteria,2JJN8@204432|Acidobacteriia 204432|Acidobacteriia - - - - - - - - - - - - - - - HSJS3_k127_4358072_12 314230.DSM3645_25562 2.446e-46 177.0 COG0248@1|root,COG0248@2|Bacteria,2IYSV@203682|Planctomycetes 203682|Planctomycetes FP Ppx GppA phosphatase - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA HSJS3_k127_4434975_11 392499.Swit_2746 4.216e-12 68.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2K14B@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD HSJS3_k127_4434975_5 382464.ABSI01000011_gene2976 3.325e-36 142.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 HSJS3_k127_4434975_7 526227.Mesil_2528 3.326e-24 109.0 COG2318@1|root,COG2318@2|Bacteria,1WNBD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S DinB superfamily - - - - - - - - - - - - DinB_2 HSJS3_k127_4434975_2 309807.SRU_0894 9.024e-83 288.0 COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase HSJS3_k127_4434975_3 795797.C497_12322 1.606e-57 208.0 COG3369@1|root,arCOG03175@1|root,arCOG03174@2157|Archaea,arCOG03175@2157|Archaea,2Y1YC@28890|Euryarchaeota,23ZKU@183963|Halobacteria 183963|Halobacteria S CDGSH-type zinc finger. Function unknown. - - - - - - - - - - - - Fer4_19,zf-CDGSH HSJS3_k127_4434975_6 1121933.AUHH01000033_gene28 6.324e-35 136.0 COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4DRQ2@85009|Propionibacteriales 201174|Actinobacteria S Uncharacterized conserved protein (DUF2277) - - - - - - - - - - - - DUF2277 HSJS3_k127_4434975_0 1089550.ATTH01000001_gene1477 1.438e-163 542.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1FIMC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S repeat protein - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_4434975_1 1125863.JAFN01000001_gene1010 3.513e-110 373.0 COG0534@1|root,COG0534@2|Bacteria,1R3WH@1224|Proteobacteria,42Q54@68525|delta/epsilon subdivisions,2WM10@28221|Deltaproteobacteria 28221|Deltaproteobacteria V Mate efflux family protein - - - - - - - - - - - - - HSJS3_k127_4434975_12 861299.J421_2223 0.0003873 51.0 COG4206@1|root,COG4206@2|Bacteria,1ZU97@142182|Gemmatimonadetes 2|Bacteria H TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec HSJS3_k127_4434975_4 378806.STAUR_0109 2.966e-41 154.0 COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,42U1Z@68525|delta/epsilon subdivisions,2WQ05@28221|Deltaproteobacteria,2Z1RY@29|Myxococcales 28221|Deltaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 HSJS3_k127_4434975_8 861299.J421_5875 2.456e-20 95.0 2F75B@1|root,33ZKU@2|Bacteria,1ZTZQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_4434975_10 1267535.KB906767_gene442 9.377e-18 91.0 COG2020@1|root,COG2020@2|Bacteria,3Y4P4@57723|Acidobacteria,2JJJZ@204432|Acidobacteriia 204432|Acidobacteriia O Phospholipid methyltransferase - - - - - - - - - - - - PEMT HSJS3_k127_4434975_9 349124.Hhal_2347 1.802e-19 94.0 COG0515@1|root,COG0515@2|Bacteria 349124.Hhal_2347|- KLT protein kinase activity - - - - - - - - - - - - - HSJS3_k127_4475241_1 1448389.BAVQ01000072_gene2684 1.071e-13 73.0 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 HSJS3_k127_4475241_3 381666.H16_B0761 1.123e-08 64.0 COG1309@1|root,COG1309@2|Bacteria,1MYVX@1224|Proteobacteria,2W5CU@28216|Betaproteobacteria 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N HSJS3_k127_4475241_0 1173024.KI912153_gene149 1.939e-94 338.0 COG1680@1|root,COG1680@2|Bacteria,1G4D0@1117|Cyanobacteria,1JJ3C@1189|Stigonemataceae 1117|Cyanobacteria V PFAM beta-lactamase - - - - - - - - - - - - Beta-lactamase HSJS3_k127_4475241_4 394221.Mmar10_0325 7.967e-08 62.0 2ECN7@1|root,32Y4C@2|Bacteria,1NEKK@1224|Proteobacteria,2UXB7@28211|Alphaproteobacteria,440JV@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_4475241_2 861299.J421_5701 2.012e-11 70.0 COG3391@1|root,COG3391@2|Bacteria,1ZUFZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amine dehydrogenase activity - - - - - - - - - - - - - HSJS3_k127_4758774_5 1278073.MYSTI_03753 6.026e-14 75.0 COG1538@1|root,COG1538@2|Bacteria,1Q54P@1224|Proteobacteria,42NQV@68525|delta/epsilon subdivisions,2X5KQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria MU CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP HSJS3_k127_4758774_3 211165.AJLN01000101_gene4391 5.325e-32 143.0 COG4191@1|root,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1JJPK@1189|Stigonemataceae 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4 HSJS3_k127_4758774_4 153721.MYP_2697 8.702e-16 91.0 COG4251@1|root,COG5000@1|root,COG4251@2|Bacteria,COG5000@2|Bacteria,4NF1K@976|Bacteroidetes 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_9 HSJS3_k127_4758774_2 1333998.M2A_2471 1.974e-77 269.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,4BRH5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex HSJS3_k127_4758774_0 309807.SRU_1123 1.152e-152 490.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,4NDZ9@976|Bacteroidetes,1FK12@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP HSJS3_k127_4758774_1 518766.Rmar_2133 5.921e-129 427.0 COG1629@1|root,COG4771@2|Bacteria,4NFKZ@976|Bacteroidetes,1FIJR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec HSJS3_k127_4897903_1 1408433.JHXV01000027_gene3706 2.819e-49 187.0 COG0702@1|root,COG0702@2|Bacteria,4NFUX@976|Bacteroidetes 976|Bacteroidetes GM SPTR NmrA family protein - - - - - - - - - - - - NAD_binding_10 HSJS3_k127_4897903_0 1499967.BAYZ01000181_gene4512 2.069e-75 258.0 COG0500@1|root,COG2226@2|Bacteria,2NRU6@2323|unclassified Bacteria 2|Bacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - HTH_17,Methyltransf_11,Methyltransf_31,Sigma70_r2,Sigma70_r4_2 HSJS3_k127_4905006_0 394221.Mmar10_0331 4.834e-74 274.0 COG4783@1|root,COG5616@1|root,COG4783@2|Bacteria,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C HSJS3_k127_4905006_1 1122604.JONR01000004_gene853 1.529e-54 215.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - HSJS3_k127_4905006_2 926566.Terro_0978 0.000607 47.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y59I@57723|Acidobacteria,2JJNP@204432|Acidobacteriia 204432|Acidobacteriia S Tetratricopeptide repeat - - - - - - - - - - - - - HSJS3_k127_4968865_18 1122604.JONR01000004_gene851 1.021e-29 132.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_4968865_25 1232410.KI421412_gene421 2.515e-05 51.0 2EBKH@1|root,335KX@2|Bacteria,1NAWH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - HSJS3_k127_4968865_7 1123242.JH636435_gene1379 7.545e-95 323.0 COG3386@1|root,COG3386@2|Bacteria,2IZFH@203682|Planctomycetes 203682|Planctomycetes G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL HSJS3_k127_4968865_10 1280950.HJO_13121 2.262e-67 252.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C HSJS3_k127_4968865_24 452637.Oter_0385 5.12e-07 58.0 COG0810@1|root,COG0810@2|Bacteria,46WNS@74201|Verrucomicrobia 74201|Verrucomicrobia M Gram-negative bacterial TonB protein C-terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C HSJS3_k127_4968865_21 1337936.IJ00_06620 9.964e-15 81.0 COG0726@1|root,COG0726@2|Bacteria,1G0GG@1117|Cyanobacteria,1HRNI@1161|Nostocales 1117|Cyanobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 HSJS3_k127_4968865_22 266117.Rxyl_3096 1.563e-12 74.0 2CF6T@1|root,31NZH@2|Bacteria,2H3K2@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - HSJS3_k127_4968865_9 344747.PM8797T_05845 8.413e-70 254.0 COG1216@1|root,COG1216@2|Bacteria,2IZF5@203682|Planctomycetes 203682|Planctomycetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 HSJS3_k127_4968865_6 518766.Rmar_0040 3.79e-101 337.0 COG2126@1|root,COG2126@2|Bacteria,4NEX1@976|Bacteroidetes 976|Bacteroidetes J Pfam Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans HSJS3_k127_4968865_5 324602.Caur_0549 4.926e-104 350.0 COG2128@1|root,COG2128@2|Bacteria,2G7WP@200795|Chloroflexi,376HC@32061|Chloroflexia 32061|Chloroflexia S Protein of unknown function (DUF3179) - - - - - - - - - - - - DUF3179 HSJS3_k127_4968865_19 1282876.BAOK01000001_gene1175 2.739e-28 122.0 COG3409@1|root,COG3409@2|Bacteria,1NP3I@1224|Proteobacteria,2UM8V@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - - HSJS3_k127_4968865_16 1384056.N787_13230 7.774e-36 148.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1X3W9@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans HSJS3_k127_4968865_8 379066.GAU_2191 8.238e-71 258.0 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity - - 2.7.13.3 ko:K07711,ko:K14980,ko:K18143 ko01501,ko02020,ko02024,map01501,map02020,map02024 M00502,M00520,M00649,M00655 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA,MFS_1,dCache_1 HSJS3_k127_4968865_3 671143.DAMO_1876 3.107e-120 401.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system nla6 - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat HSJS3_k127_4968865_23 234267.Acid_2726 8.051e-10 68.0 COG2823@1|root,COG2823@2|Bacteria,3Y7TR@57723|Acidobacteria 57723|Acidobacteria S Periplasmic or secreted lipoprotein - - - - - - - - - - - - - HSJS3_k127_4968865_14 1379270.AUXF01000003_gene3644 4.833e-39 154.0 COG2885@1|root,COG2885@2|Bacteria,1ZTR2@142182|Gemmatimonadetes 142182|Gemmatimonadetes M OmpA family - - - - - - - - - - - - OmpA HSJS3_k127_4968865_2 502025.Hoch_5783 4.591e-125 412.0 COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,42PBG@68525|delta/epsilon subdivisions,2WK4S@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Glutamate-cysteine ligase - - - - - - - - - - - - GCS2 HSJS3_k127_4968865_1 1123393.KB891326_gene66 5.151e-167 539.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,2VJP0@28216|Betaproteobacteria,1KS9Q@119069|Hydrogenophilales 119069|Hydrogenophilales HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - RLAN HSJS3_k127_4968865_17 1121930.AQXG01000002_gene2211 5.125e-35 143.0 COG2345@1|root,COG2345@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_20 HSJS3_k127_4968865_15 1237149.C900_03373 1.658e-36 143.0 COG2010@1|root,COG2010@2|Bacteria,4NMD5@976|Bacteroidetes 976|Bacteroidetes C cytochrome C - - - - - - - - - - - - Cytochrom_C HSJS3_k127_4968865_0 1191523.MROS_1104 1.83e-305 948.0 COG4263@1|root,COG4263@2|Bacteria 2|Bacteria C nitrous-oxide reductase activity nosZ GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 ko:K00376,ko:K02275 ko00190,ko00910,ko01100,ko01120,map00190,map00910,map01100,map01120 M00155,M00529 R00081,R02804 RC00016,RC02861 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,Cupredoxin_1 HSJS3_k127_4968865_12 379066.GAU_1384 2.818e-56 202.0 COG4314@1|root,COG4314@2|Bacteria 2|Bacteria C lipoprotein involved in nitrous oxide reduction nosL - - ko:K19342 - - - - ko00000 - - - NosL HSJS3_k127_4968865_4 1279009.ADICEAN_01491 8.433e-118 395.0 COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,47KEF@768503|Cytophagia 976|Bacteroidetes P Periplasmic copper-binding protein (NosD) nosD - - ko:K07218 - - - - ko00000 - - - NosD HSJS3_k127_4968865_11 925409.KI911562_gene943 3.579e-63 231.0 COG1131@1|root,COG1131@2|Bacteria,4NG9T@976|Bacteroidetes,1IPBT@117747|Sphingobacteriia 976|Bacteroidetes V ABC-type multidrug transport system ATPase component - - - ko:K19340 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC_tran HSJS3_k127_4968865_13 1279009.ADICEAN_01493 1.29e-46 183.0 COG1277@1|root,COG1277@2|Bacteria,4NGGR@976|Bacteroidetes,47KSX@768503|Cytophagia 976|Bacteroidetes S ABC-2 family transporter protein - - - ko:K19341 ko02010,map02010 M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1.132.2 - - ABC2_membrane_2,ABC2_membrane_5 HSJS3_k127_4968865_20 997346.HMPREF9374_3978 5.043e-27 117.0 COG1525@1|root,COG1525@2|Bacteria,1V3MZ@1239|Firmicutes,4HHPS@91061|Bacilli,27CPE@186824|Thermoactinomycetaceae 91061|Bacilli L Staphylococcal nuclease homologues nucH - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase HSJS3_k127_4968865_26 1282356.H045_09905 0.0001846 44.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1YNCX@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria Q Peptide synthetase pvdI - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,TauD,Thioesterase HSJS3_k127_5528012_29 1128421.JAGA01000002_gene1321 9.077e-17 83.0 COG1597@1|root,COG1597@2|Bacteria,2NR9K@2323|unclassified Bacteria 2|Bacteria I Diacylglycerol kinase catalytic domain (presumed) dagK GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.107 ko:K07029 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_cat HSJS3_k127_5528012_21 1382359.JIAL01000001_gene3007 4.74e-33 142.0 COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria,2JJ4W@204432|Acidobacteriia 204432|Acidobacteriia O PDZ DHR GLGF domain protein - - - - - - - - - - - - PDZ_2 HSJS3_k127_5528012_15 1089550.ATTH01000001_gene1932 1.713e-54 207.0 COG1714@1|root,COG1714@2|Bacteria 2|Bacteria S RDD family - - - - - - - - - - - - RDD HSJS3_k127_5528012_30 68170.KL590470_gene11213 4.462e-11 74.0 COG3595@1|root,COG3595@2|Bacteria,2I8IR@201174|Actinobacteria,4E6FZ@85010|Pseudonocardiales 201174|Actinobacteria S Putative adhesin - - - - - - - - - - - - DUF4097 HSJS3_k127_5528012_1 118163.Ple7327_4031 1.895e-188 608.0 COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,3VIBA@52604|Pleurocapsales 1117|Cyanobacteria E Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N HSJS3_k127_5528012_9 313606.M23134_04872 1.043e-81 281.0 COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,47KSG@768503|Cytophagia 976|Bacteroidetes E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase HSJS3_k127_5528012_3 926550.CLDAP_14210 1.946e-144 465.0 COG1899@1|root,COG1899@2|Bacteria,2G7R7@200795|Chloroflexi 200795|Chloroflexi O PFAM deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS HSJS3_k127_5528012_24 1160137.KB907307_gene2696 4.05e-30 123.0 COG0640@1|root,COG0640@2|Bacteria,2IKQY@201174|Actinobacteria,4G8J4@85025|Nocardiaceae 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 HSJS3_k127_5528012_25 1267534.KB906755_gene4336 1.182e-27 122.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - AHSA1 HSJS3_k127_5528012_4 589865.DaAHT2_1709 1.573e-143 469.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales 28221|Deltaproteobacteria J RNA-metabolising metallo-beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL HSJS3_k127_5528012_10 102129.Lepto7375DRAFT_2322 1.452e-73 256.0 COG1611@1|root,COG1611@2|Bacteria,1G0YF@1117|Cyanobacteria,1HF8H@1150|Oscillatoriales 1117|Cyanobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox HSJS3_k127_5528012_14 1128421.JAGA01000003_gene2924 1.632e-58 211.0 2CAZH@1|root,2Z7RU@2|Bacteria,2NRIS@2323|unclassified Bacteria 2|Bacteria - - sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt HSJS3_k127_5528012_0 867845.KI911784_gene1291 1.186e-321 994.0 COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia 32061|Chloroflexia C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C HSJS3_k127_5528012_6 861299.J421_3298 7.066e-112 367.0 COG0479@1|root,COG0479@2|Bacteria,1ZT02@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S binding domain - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 HSJS3_k127_5528012_27 342949.PNA2_1768 1.56e-20 106.0 COG0819@1|root,arCOG01128@2157|Archaea,2Y6B2@28890|Euryarchaeota,243SP@183968|Thermococci 183968|Thermococci K TENA/THI-4/PQQC family - - - ko:K20896 ko00730,ko01100,map00730,map01100 - R09993,R11313 RC00197,RC02832 ko00000,ko00001,ko01000 - - - TENA_THI-4 HSJS3_k127_5528012_28 953739.SVEN_7120 7.47e-20 95.0 COG1595@1|root,COG2340@1|root,COG1595@2|Bacteria,COG2340@2|Bacteria,2GJ21@201174|Actinobacteria 201174|Actinobacteria K belongs to the sigma-70 factor family - - - - - - - - - - - - CAP,Sigma70_r2 HSJS3_k127_5528012_31 379066.GAU_2624 6.098e-08 57.0 COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - - - - - - - - - - - AhpC-TSA HSJS3_k127_5528012_26 379066.GAU_2624 1.099e-22 101.0 COG1225@1|root,COG1225@2|Bacteria,1ZUGC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Redoxin - - - - - - - - - - - - AhpC-TSA HSJS3_k127_5528012_20 861299.J421_1716 8.93e-34 145.0 COG0526@1|root,COG0526@2|Bacteria,1ZTV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA HSJS3_k127_5528012_13 1379270.AUXF01000001_gene2065 5.616e-61 222.0 COG4232@1|root,COG4232@2|Bacteria,1ZSQP@142182|Gemmatimonadetes 142182|Gemmatimonadetes CO Cytochrome C biogenesis protein transmembrane region - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbD HSJS3_k127_5528012_2 649638.Trad_2970 6.824e-159 515.0 COG0534@1|root,COG0534@2|Bacteria,1WMCE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V COGs COG0534 Na -driven multidrug efflux pump - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE HSJS3_k127_5528012_23 861299.J421_1009 5.321e-31 125.0 COG1846@1|root,COG1846@2|Bacteria,1ZU3J@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_34 HSJS3_k127_5528012_19 1128421.JAGA01000001_gene2144 3.497e-35 151.0 COG3127@1|root,COG3127@2|Bacteria 2|Bacteria Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD HSJS3_k127_5528012_17 379066.GAU_2187 4.31e-51 187.0 COG0431@1|root,COG0431@2|Bacteria,1ZUYE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S NADPH-dependent FMN reductase - - - ko:K19784 - - - - ko00000 - - - FMN_red HSJS3_k127_5528012_7 429009.Adeg_1912 3.129e-109 364.0 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,42EJY@68295|Thermoanaerobacterales 186801|Clostridia E DAHP synthetase I family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 HSJS3_k127_5528012_16 1078085.HMPREF1210_02261 2.64e-53 197.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,4HFQ8@91061|Bacilli,26DK3@186818|Planococcaceae 91061|Bacilli E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA HSJS3_k127_5528012_5 525904.Tter_1249 5.157e-143 469.0 COG0133@1|root,COG0133@2|Bacteria,2NNWF@2323|unclassified Bacteria 2|Bacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP HSJS3_k127_5528012_22 463191.SSEG_02541 2.521e-32 135.0 COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria 201174|Actinobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI HSJS3_k127_5528012_18 1150599.MPHLEI_01616 1.839e-39 159.0 COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,232KE@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the TrpC family trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS HSJS3_k127_5528012_11 429009.Adeg_1160 1.641e-71 254.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 HSJS3_k127_5528012_12 635013.TherJR_1606 1.184e-64 234.0 COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,261J7@186807|Peptococcaceae 186801|Clostridia EH TIGRFAM glutamine amidotransferase of anthranilate synthase pabA - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase HSJS3_k127_5528012_8 1121918.ARWE01000001_gene2336 9.248e-104 351.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43T7B@69541|Desulfuromonadales 28221|Deltaproteobacteria EH Anthranilate synthase component I, N terminal region trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind HSJS3_k127_5606793_1 1379698.RBG1_1C00001G0781 4.495e-51 187.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N HSJS3_k127_5606793_0 1379698.RBG1_1C00001G0780 2.327e-131 429.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B HSJS3_k127_5777444_6 32264.tetur08g07360.1 0.0001812 54.0 COG0545@1|root,KOG0543@2759|Eukaryota,38BCC@33154|Opisthokonta,3B9T6@33208|Metazoa,3CT9W@33213|Bilateria,41W8C@6656|Arthropoda 33208|Metazoa O It is involved in the biological process described with protein folding FKBP5 GO:0000003,GO:0000041,GO:0000166,GO:0000413,GO:0001655,GO:0001882,GO:0001883,GO:0003006,GO:0003008,GO:0003674,GO:0003755,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005527,GO:0005528,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006463,GO:0006464,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0007154,GO:0007165,GO:0007275,GO:0007399,GO:0007422,GO:0007548,GO:0007565,GO:0007566,GO:0007600,GO:0007601,GO:0008092,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009416,GO:0009581,GO:0009582,GO:0009583,GO:0009584,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009719,GO:0009725,GO:0009755,GO:0009987,GO:0010033,GO:0010639,GO:0010721,GO:0010959,GO:0010975,GO:0010977,GO:0014070,GO:0016020,GO:0016027,GO:0016028,GO:0016043,GO:0016853,GO:0016859,GO:0017076,GO:0018193,GO:0018208,GO:0019001,GO:0019538,GO:0019897,GO:0019898,GO:0022008,GO:0022414,GO:0022607,GO:0023052,GO:0030001,GO:0030154,GO:0030424,GO:0030426,GO:0030427,GO:0030518,GO:0030521,GO:0030522,GO:0030554,GO:0030674,GO:0030850,GO:0031072,GO:0031110,GO:0031111,GO:0031113,GO:0031115,GO:0031333,GO:0031344,GO:0031345,GO:0031503,GO:0031974,GO:0031981,GO:0032271,GO:0032272,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032767,GO:0032870,GO:0032879,GO:0032886,GO:0032991,GO:0033043,GO:0033267,GO:0033993,GO:0034622,GO:0035257,GO:0035258,GO:0035259,GO:0035639,GO:0036094,GO:0036211,GO:0036477,GO:0042221,GO:0042995,GO:0043005,GO:0043025,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043254,GO:0043269,GO:0043401,GO:0043412,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044295,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044706,GO:0045595,GO:0045596,GO:0045664,GO:0045665,GO:0046661,GO:0048156,GO:0048471,GO:0048513,GO:0048519,GO:0048523,GO:0048545,GO:0048583,GO:0048608,GO:0048699,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050767,GO:0050768,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050896,GO:0050906,GO:0050908,GO:0050953,GO:0050962,GO:0051049,GO:0051093,GO:0051128,GO:0051129,GO:0051179,GO:0051219,GO:0051234,GO:0051239,GO:0051241,GO:0051427,GO:0051493,GO:0051494,GO:0051606,GO:0051704,GO:0051707,GO:0051716,GO:0051879,GO:0051924,GO:0051960,GO:0051961,GO:0060090,GO:0060284,GO:0061077,GO:0061458,GO:0065003,GO:0065007,GO:0070013,GO:0070507,GO:0070887,GO:0071310,GO:0071383,GO:0071396,GO:0071407,GO:0071495,GO:0071704,GO:0071840,GO:0071944,GO:0080134,GO:0080135,GO:0097159,GO:0097367,GO:0097458,GO:0098796,GO:0098797,GO:0120025,GO:0120035,GO:0120038,GO:0140096,GO:0150034,GO:1900034,GO:1901265,GO:1901363,GO:1901564,GO:1902903,GO:1902904,GO:2000026 3.1.3.16,5.2.1.8 ko:K06269,ko:K09571,ko:K12487 ko03015,ko04022,ko04024,ko04113,ko04114,ko04144,ko04218,ko04261,ko04270,ko04390,ko04510,ko04611,ko04720,ko04728,ko04750,ko04810,ko04910,ko04915,ko04921,ko04931,ko05031,ko05034,ko05168,ko05205,map03015,map04022,map04024,map04113,map04114,map04144,map04218,map04261,map04270,map04390,map04510,map04611,map04720,map04728,map04750,map04810,map04910,map04915,map04921,map04931,map05031,map05034,map05168,map05205 - - - ko00000,ko00001,ko01000,ko01009,ko03019,ko03021,ko03041,ko03110,ko04131 - - - FKBP_C,TPR_1,TPR_2,TPR_8 HSJS3_k127_5777444_4 861299.J421_3065 9.643e-22 108.0 2DUTE@1|root,33S5W@2|Bacteria,1ZSMI@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_5777444_1 562970.Btus_1333 1.636e-80 283.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,2782F@186823|Alicyclobacillaceae 91061|Bacilli J Responsible for synthesis of pseudouridine from uracil rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 HSJS3_k127_5777444_3 1379270.AUXF01000005_gene663 4.659e-38 153.0 COG0597@1|root,COG0597@2|Bacteria,1ZTWA@142182|Gemmatimonadetes 142182|Gemmatimonadetes M This protein specifically catalyzes the removal of signal peptides from prolipoproteins - - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 HSJS3_k127_5777444_2 379066.GAU_1400 5.641e-49 177.0 COG1734@1|root,COG1734@2|Bacteria,1ZTP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR HSJS3_k127_5777444_0 1379698.RBG1_1C00001G0103 3.853e-133 444.0 COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria 2|Bacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 HSJS3_k127_6000877_81 861299.J421_6034 4.68e-48 196.0 COG3629@1|root,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - - - - - - - - - - - AAA_16,Abhydrolase_1,BTAD,Guanylate_cyc,Trans_reg_C HSJS3_k127_6000877_113 1267533.KB906733_gene3362 6.411e-28 132.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia 204432|Acidobacteriia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C HSJS3_k127_6000877_43 1121920.AUAU01000012_gene2631 4.747e-96 347.0 COG1629@1|root,COG4771@2|Bacteria,3Y3ZU@57723|Acidobacteria 57723|Acidobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec HSJS3_k127_6000877_116 234267.Acid_7851 1.194e-26 126.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria 57723|Acidobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - HSJS3_k127_6000877_100 861299.J421_1819 6.709e-38 157.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - 1.7.2.1 ko:K00368,ko:K02638 ko00195,ko00910,ko01120,map00195,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko00194,ko01000 - - - Copper-bind,Cupredoxin_1 HSJS3_k127_6000877_142 485913.Krac_8476 7.521e-05 51.0 COG3794@1|root,COG3794@2|Bacteria,2G7GX@200795|Chloroflexi 200795|Chloroflexi C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 HSJS3_k127_6000877_24 616991.JPOO01000003_gene2343 5.354e-135 438.0 COG3119@1|root,COG3119@2|Bacteria,4NF21@976|Bacteroidetes,1HZ1G@117743|Flavobacteriia,23GBB@178469|Arenibacter 976|Bacteroidetes P Metalloenzyme superfamily - - - - - - - - - - - - Metalloenzyme,Sulfatase HSJS3_k127_6000877_15 379066.GAU_0444 6.974e-152 496.0 COG0624@1|root,COG0624@2|Bacteria,1ZT2K@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 HSJS3_k127_6000877_128 910964.GEAM_1331 1.504e-19 94.0 COG0251@1|root,COG0251@2|Bacteria,1RF7A@1224|Proteobacteria,1S72W@1236|Gammaproteobacteria 1236|Gammaproteobacteria J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP HSJS3_k127_6000877_79 391603.FBALC1_04002 1.297e-50 191.0 COG3386@1|root,COG3386@2|Bacteria,4PKCK@976|Bacteroidetes,1IJ7K@117743|Flavobacteriia 976|Bacteroidetes G cell adhesion involved in biofilm formation - - - - - - - - - - - - - HSJS3_k127_6000877_19 1192034.CAP_6654 2.63e-140 466.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 HSJS3_k127_6000877_44 1151061.CAJY01000017_gene250 5.664e-95 327.0 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria 201174|Actinobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA2 - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N HSJS3_k127_6000877_17 1089550.ATTH01000001_gene237 1.071e-145 485.0 COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 HSJS3_k127_6000877_105 502025.Hoch_4479 1.601e-36 155.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC HSJS3_k127_6000877_76 1345697.M493_10975 1.547e-56 213.0 COG0318@1|root,COG0318@2|Bacteria,1UKBR@1239|Firmicutes,4ITH5@91061|Bacilli,1WH7V@129337|Geobacillus 91061|Bacilli IQ Acyl-protein synthetase, LuxE - - - - - - - - - - - - LuxE HSJS3_k127_6000877_144 118161.KB235922_gene827 0.0007651 51.0 COG0265@1|root,COG0265@2|Bacteria,1G17C@1117|Cyanobacteria,3VHQ5@52604|Pleurocapsales 1117|Cyanobacteria O PDZ domain (Also known as DHR or GLGF) hhoA GO:0003674,GO:0005488,GO:0005515,GO:0042802 - - - - - - - - - - PDZ_2,Trypsin_2 HSJS3_k127_6000877_139 1379270.AUXF01000001_gene2410 7.755e-09 65.0 2F7PW@1|root,34048@2|Bacteria,1ZTZH@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_6000877_95 502025.Hoch_4167 6.781e-41 158.0 COG1595@1|root,COG1595@2|Bacteria,1PEU8@1224|Proteobacteria,42T76@68525|delta/epsilon subdivisions,2WPVH@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_6000877_31 1123073.KB899241_gene2287 2.321e-117 392.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales 135614|Xanthomonadales E Glycine cleavage T-protein C-terminal barrel domain - - - - - - - - - - - - GCV_T,GCV_T_C HSJS3_k127_6000877_5 204669.Acid345_1270 2.828e-213 676.0 COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia 204432|Acidobacteriia Q Flavin containing amine oxidoreductase - - - - - - - - - - - - NAD_binding_8 HSJS3_k127_6000877_70 1380350.JIAP01000003_gene4952 7.533e-61 235.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 HSJS3_k127_6000877_115 1382356.JQMP01000001_gene881 2.746e-27 115.0 COG3439@1|root,COG3439@2|Bacteria,2G72I@200795|Chloroflexi,27Z7D@189775|Thermomicrobia 189775|Thermomicrobia S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 HSJS3_k127_6000877_114 861299.J421_0797 9.492e-28 128.0 COG0671@1|root,COG0671@2|Bacteria 2|Bacteria I phosphatidate phosphatase activity dgkA - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 ko:K00901,ko:K01096,ko:K19302 ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02029,R02240,R05627 RC00002,RC00017 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_2369 DAGK_prokar,PAP2,PAP2_3 HSJS3_k127_6000877_60 42256.RradSPS_2789 1.013e-70 252.0 COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria 201174|Actinobacteria M 3-beta hydroxysteroid dehydrogenase isomerase - - - - - - - - - - - - Epimerase HSJS3_k127_6000877_41 1379698.RBG1_1C00001G0533 8.301e-98 343.0 COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria 2|Bacteria K acetyltransferase yghO - - - - - - - - - - - Acetyltransf_1 HSJS3_k127_6000877_22 1379698.RBG1_1C00001G0532 4.938e-137 449.0 COG0156@1|root,COG0156@2|Bacteria,2NNMX@2323|unclassified Bacteria 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 HSJS3_k127_6000877_73 234267.Acid_4469 3.143e-58 217.0 COG2227@1|root,COG2227@2|Bacteria,3Y2SJ@57723|Acidobacteria 57723|Acidobacteria H PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 HSJS3_k127_6000877_75 740709.A10D4_00735 1.462e-57 210.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S0GF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta mhpC - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 HSJS3_k127_6000877_111 1105367.CG50_04950 3.241e-30 123.0 COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,2UCCY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Lipid A Biosynthesis - - - - - - - - - - - - LAB_N HSJS3_k127_6000877_66 1125863.JAFN01000001_gene685 9.202e-67 237.0 COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,43BKJ@68525|delta/epsilon subdivisions,2WIZJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 HSJS3_k127_6000877_126 240016.ABIZ01000001_gene3012 7.585e-23 114.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 HSJS3_k127_6000877_77 203124.Tery_1772 3.335e-54 209.0 COG3391@1|root,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria,1H803@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS HSJS3_k127_6000877_32 344747.PM8797T_05550 4.013e-117 402.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2IZS3@203682|Planctomycetes 203682|Planctomycetes L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18 HSJS3_k127_6000877_138 1121405.dsmv_2025 2.678e-09 61.0 COG3478@1|root,COG3478@2|Bacteria,1P0EH@1224|Proteobacteria,431E0@68525|delta/epsilon subdivisions,2WWIK@28221|Deltaproteobacteria,2MNXS@213118|Desulfobacterales 28221|Deltaproteobacteria S Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) - - - - - - - - - - - - - HSJS3_k127_6000877_62 589865.DaAHT2_1614 1.146e-69 244.0 COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,42R9E@68525|delta/epsilon subdivisions,2WNRJ@28221|Deltaproteobacteria,2MPAU@213118|Desulfobacterales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE HSJS3_k127_6000877_87 1123278.KB893604_gene1945 4.614e-44 171.0 COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,47PEN@768503|Cytophagia 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 HSJS3_k127_6000877_59 751944.HALDL1_11185 1.044e-73 265.0 COG1028@1|root,arCOG01259@2157|Archaea,2XV13@28890|Euryarchaeota,23URP@183963|Halobacteria 183963|Halobacteria I COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 HSJS3_k127_6000877_45 1192034.CAP_0196 3.116e-93 322.0 COG3503@1|root,COG3503@2|Bacteria,1QQ9D@1224|Proteobacteria,431ME@68525|delta/epsilon subdivisions,2WWTB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF1624) - - - - - - - - - - - - DUF1624 HSJS3_k127_6000877_65 1267535.KB906767_gene476 8.151e-67 242.0 COG0500@1|root,COG2226@2|Bacteria,3Y5HG@57723|Acidobacteria 57723|Acidobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 HSJS3_k127_6000877_94 56780.SYN_02013 4.118e-41 162.0 COG1539@1|root,COG1539@2|Bacteria,1QVAP@1224|Proteobacteria,43BPU@68525|delta/epsilon subdivisions,2X712@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier HSJS3_k127_6000877_127 1278307.KB906983_gene3914 1.476e-22 102.0 COG0607@1|root,COG0607@2|Bacteria,1RHVM@1224|Proteobacteria,1SD9C@1236|Gammaproteobacteria,2QJ6Y@267894|Psychromonadaceae 1236|Gammaproteobacteria P Rhodanese Homology Domain pspE GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K03972 - - - - ko00000 - - iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779 Rhodanese HSJS3_k127_6000877_98 1379270.AUXF01000002_gene1539 3.663e-39 156.0 2C7E0@1|root,330TX@2|Bacteria,1ZUQG@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_6000877_84 1121015.N789_09300 1.921e-46 171.0 COG0394@1|root,COG0394@2|Bacteria 2|Bacteria T Belongs to the low molecular weight phosphotyrosine protein phosphatase family arsC - 1.20.4.1,2.8.4.2,3.1.3.48 ko:K01104,ko:K03325,ko:K03741,ko:K03892,ko:K18701 - - - - ko00000,ko01000,ko02000,ko03000 2.A.59 - - LMWPc HSJS3_k127_6000877_92 411464.DESPIG_01057 2.498e-41 169.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WP2C@28221|Deltaproteobacteria,2M7QN@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Peptidase M23 - - - - - - - - - - - - Peptidase_M23 HSJS3_k127_6000877_82 1499967.BAYZ01000094_gene4048 8.615e-48 192.0 COG1752@1|root,COG1752@2|Bacteria 2|Bacteria M Esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin HSJS3_k127_6000877_4 1121920.AUAU01000023_gene2395 2.704e-227 722.0 COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria 2|Bacteria E 3-isopropylmalate dehydratase activity leuD - 4.2.1.3,4.2.1.33,4.2.1.35 ko:K01681,ko:K01703,ko:K01704,ko:K17749 ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00432,M00535,M00740 R01324,R01325,R01900,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501 RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C HSJS3_k127_6000877_1 504472.Slin_1834 7.293e-289 919.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47K02@768503|Cytophagia 976|Bacteroidetes S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C HSJS3_k127_6000877_108 1112212.JH584235_gene2848 1.811e-35 143.0 COG0073@1|root,COG0073@2|Bacteria,1RGU7@1224|Proteobacteria,2U9AH@28211|Alphaproteobacteria,2K52N@204457|Sphingomonadales 204457|Sphingomonadales J Putative tRNA binding domain csaA - - ko:K06878 - - - - ko00000 - - - tRNA_bind HSJS3_k127_6000877_110 861299.J421_2520 1.754e-32 140.0 COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Glycine cleavage T-protein C-terminal barrel domain - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C HSJS3_k127_6000877_63 861299.J421_3598 2.54e-67 241.0 COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes 2|Bacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) bfmBA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C HSJS3_k127_6000877_27 861299.J421_3597 7.884e-124 407.0 COG0022@1|root,COG0022@2|Bacteria,1ZT89@142182|Gemmatimonadetes 2|Bacteria C Transketolase, pyrimidine binding domain bfmBA - 1.2.4.4 ko:K00167,ko:K11381,ko:K21417 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C HSJS3_k127_6000877_34 1267535.KB906767_gene5278 3.519e-114 384.0 COG0508@1|root,COG0508@2|Bacteria,3Y3CV@57723|Acidobacteria,2JHPY@204432|Acidobacteriia 204432|Acidobacteriia C e3 binding domain - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding HSJS3_k127_6000877_88 1242864.D187_007526 5.274e-44 177.0 COG0845@1|root,COG0845@2|Bacteria,1R50D@1224|Proteobacteria 1224|Proteobacteria M COG0845 Membrane-fusion protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 HSJS3_k127_6000877_38 234267.Acid_6481 2.42e-105 346.0 COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria 57723|Acidobacteria V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran HSJS3_k127_6000877_12 926566.Terro_2393 3.125e-164 530.0 COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia 204432|Acidobacteriia T response regulator - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat HSJS3_k127_6000877_23 1242864.D187_007523 8.322e-136 447.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,4345U@68525|delta/epsilon subdivisions,2X20T@28221|Deltaproteobacteria,2YVEZ@29|Myxococcales 28221|Deltaproteobacteria T PAS domain - - - - - - - - - - - - HATPase_c,PAS HSJS3_k127_6000877_9 861299.J421_1696 1.51e-190 623.0 COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 HSJS3_k127_6000877_74 765913.ThidrDRAFT_3335 3.776e-58 211.0 COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,1RRS1@1236|Gammaproteobacteria,1WW2T@135613|Chromatiales 135613|Chromatiales G TIGRFAM HAD-superfamily subfamily IIA hydrolase like protein - - - - - - - - - - - - Hydrolase_6,Hydrolase_like HSJS3_k127_6000877_72 1283299.AUKG01000001_gene3257 5.746e-59 220.0 COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria,4CS23@84995|Rubrobacteria 84995|Rubrobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 HSJS3_k127_6000877_140 335541.Swol_1837 2.055e-08 63.0 COG1848@1|root,COG1848@2|Bacteria,1U5UN@1239|Firmicutes,25P95@186801|Clostridia,42KUD@68298|Syntrophomonadaceae 186801|Clostridia S Large family of predicted nucleotide-binding domains - - - - - - - - - - - - PIN HSJS3_k127_6000877_143 479434.Sthe_3271 0.0004308 46.0 COG2002@1|root,COG2002@2|Bacteria 2|Bacteria K toxin-antitoxin pair type II binding - - - - - - - - - - - - MazE_antitoxin HSJS3_k127_6000877_68 1121405.dsmv_1233 1.225e-61 223.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,42MUA@68525|delta/epsilon subdivisions,2WJWH@28221|Deltaproteobacteria,2MHNQ@213118|Desulfobacterales 28221|Deltaproteobacteria P TIGRFAM Na Ca antiporter, CaCA family - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex,PGPGW HSJS3_k127_6000877_132 1242864.D187_002808 2.398e-13 76.0 COG1664@1|root,COG1664@2|Bacteria,1RHS7@1224|Proteobacteria 1224|Proteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin HSJS3_k127_6000877_117 1382356.JQMP01000001_gene1134 6.011e-26 117.0 COG0739@1|root,COG0741@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,2G6NM@200795|Chloroflexi,27XW3@189775|Thermomicrobia 189775|Thermomicrobia M Lytic transglycosylase catalytic - - - - - - - - - - - - Peptidase_M23,SLT HSJS3_k127_6000877_69 555079.Toce_2275 1.271e-61 223.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,42FPF@68295|Thermoanaerobacterales 186801|Clostridia K Belongs to the ParB family spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc HSJS3_k127_6000877_42 861299.J421_1165 1.194e-97 325.0 COG1192@1|root,COG1192@2|Bacteria,1ZTH2@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 HSJS3_k127_6000877_10 187272.Mlg_2880 2.412e-187 606.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1WXBH@135613|Chromatiales 135613|Chromatiales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc HSJS3_k127_6000877_106 1293054.HSACCH_00330 2.188e-36 148.0 COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,3WAJM@53433|Halanaerobiales 186801|Clostridia L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS HSJS3_k127_6000877_36 379066.GAU_3931 1.798e-111 382.0 COG0486@1|root,COG0486@2|Bacteria,1ZSRA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N HSJS3_k127_6000877_39 1379270.AUXF01000002_gene1186 1.216e-103 358.0 COG0706@1|root,COG0706@2|Bacteria,1ZSKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas HSJS3_k127_6000877_118 1313301.AUGC01000004_gene2314 6.413e-26 110.0 COG0759@1|root,COG0759@2|Bacteria,4NV1N@976|Bacteroidetes 976|Bacteroidetes S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic HSJS3_k127_6000877_141 861299.J421_1069 5.765e-08 59.0 COG0594@1|root,COG0594@2|Bacteria,1ZV89@142182|Gemmatimonadetes 142182|Gemmatimonadetes J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P HSJS3_k127_6000877_134 1313301.AUGC01000001_gene1635 4.15e-11 64.0 COG0230@1|root,COG0230@2|Bacteria,4NUTV@976|Bacteroidetes 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 HSJS3_k127_6000877_26 1329516.JPST01000014_gene628 3.024e-124 413.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,27BH0@186824|Thermoactinomycetaceae 91061|Bacilli L Bacterial dnaA protein helix-turn-helix domain dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N HSJS3_k127_6000877_20 861299.J421_1072 4.875e-139 451.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 HSJS3_k127_6000877_136 266117.Rxyl_2761 6.789e-10 68.0 COG2881@1|root,COG2881@2|Bacteria 2|Bacteria M overlaps another CDS with the same product name - - - - - - - - - - - - Yip1 HSJS3_k127_6000877_107 1120934.KB894418_gene2014 5.738e-36 152.0 COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4DXPE@85010|Pseudonocardiales 201174|Actinobacteria L pfam nudix - - - - - - - - - - - - NUDIX HSJS3_k127_6000877_83 1122180.Lokhon_00221 3.72e-47 180.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2P8B2@245186|Loktanella 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B HSJS3_k127_6000877_51 1380394.JADL01000001_gene3101 1.789e-84 296.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,2JV5D@204441|Rhodospirillales 204441|Rhodospirillales EGP Sugar (and other) transporter - - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1 HSJS3_k127_6000877_48 309807.SRU_2119 4.492e-90 314.0 COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,4NDZY@976|Bacteroidetes,1FISB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L NUDIX domain mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 HSJS3_k127_6000877_102 880072.Desac_2488 1.148e-37 154.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMP4@28221|Deltaproteobacteria,2MQD5@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase HSJS3_k127_6000877_112 1123274.KB899409_gene487 3.663e-29 128.0 COG4758@1|root,COG4758@2|Bacteria,2JB2D@203691|Spirochaetes 203691|Spirochaetes S Cell wall-active antibiotics response 4TMS YvqF - - - - - - - - - - - - DUF1707,DUF2154 HSJS3_k127_6000877_91 861299.J421_2686 2.057e-42 160.0 COG0509@1|root,COG0509@2|Bacteria,1ZTWD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H HSJS3_k127_6000877_21 1120973.AQXL01000127_gene2717 7.214e-138 451.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli,2782W@186823|Alicyclobacillaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P HSJS3_k127_6000877_71 1341151.ASZU01000003_gene2288 1.056e-60 218.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,4HBM0@91061|Bacilli,27AV7@186824|Thermoactinomycetaceae 91061|Bacilli S Beta-lactamase superfamily domain bCE_4747 - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 HSJS3_k127_6000877_11 644966.Tmar_1189 9.933e-181 588.0 COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia,3WCD1@538999|Clostridiales incertae sedis 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P HSJS3_k127_6000877_123 509190.Cseg_2791 2.316e-23 112.0 2E902@1|root,3339H@2|Bacteria,1N9U6@1224|Proteobacteria,2UFG4@28211|Alphaproteobacteria,2KH8D@204458|Caulobacterales 204458|Caulobacterales - - - - - - - - - - - - - - - HSJS3_k127_6000877_124 404589.Anae109_4248 2.505e-23 102.0 2E3AG@1|root,32Y9Z@2|Bacteria,1NADT@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - HSJS3_k127_6000877_86 1128421.JAGA01000002_gene32 1.263e-45 176.0 COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria 2|Bacteria H Biotin/lipoate A/B protein ligase family lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB HSJS3_k127_6000877_54 338963.Pcar_1870 6.21e-82 293.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,43S4Y@69541|Desulfuromonadales 28221|Deltaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 HSJS3_k127_6000877_52 1235279.C772_01046 9.276e-84 299.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,26H18@186818|Planococcaceae 91061|Bacilli E Bacterial extracellular solute-binding proteins, family 5 Middle appA - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 HSJS3_k127_6000877_47 517417.Cpar_0557 6.35e-92 314.0 COG0601@1|root,COG0601@2|Bacteria,1FDDB@1090|Chlorobi 1090|Chlorobi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 HSJS3_k127_6000877_46 1125863.JAFN01000001_gene589 3.366e-92 311.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N HSJS3_k127_6000877_40 644966.Tmar_0290 1.822e-102 355.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WCCK@538999|Clostridiales incertae sedis 186801|Clostridia P Belongs to the ABC transporter superfamily oppD - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY HSJS3_k127_6000877_61 867903.ThesuDRAFT_01015 5.186e-70 245.0 COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia 186801|Clostridia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR HSJS3_k127_6000877_85 309807.SRU_1985 2.475e-46 179.0 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp HSJS3_k127_6000877_120 335543.Sfum_0737 2.013e-24 107.0 COG0589@1|root,COG0589@2|Bacteria,1NDJW@1224|Proteobacteria,430KQ@68525|delta/epsilon subdivisions,2WVKY@28221|Deltaproteobacteria,2MRZ2@213462|Syntrophobacterales 28221|Deltaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp HSJS3_k127_6000877_25 1278073.MYSTI_07008 2.206e-126 413.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B HSJS3_k127_6000877_67 215803.DB30_1753 3.019e-63 228.0 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,42MF3@68525|delta/epsilon subdivisions,2WJXS@28221|Deltaproteobacteria,2YXMB@29|Myxococcales 28221|Deltaproteobacteria G Class II Aldolase and Adducin N-terminal domain fucA - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II HSJS3_k127_6000877_18 1124780.ANNU01000028_gene952 1.072e-140 452.0 COG0175@1|root,COG0175@2|Bacteria,4NEPD@976|Bacteroidetes,47JCC@768503|Cytophagia 976|Bacteroidetes EH TIGRFAM sulfate adenylyltransferase, small subunit cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct HSJS3_k127_6000877_3 309807.SRU_0581 1.238e-231 742.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,4NETI@976|Bacteroidetes,1FJGH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Adenylylsulphate kinase cysN GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0044237 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - GTP_EFTU HSJS3_k127_6000877_0 391625.PPSIR1_18075 1.008e-301 944.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 HSJS3_k127_6000877_7 1121930.AQXG01000001_gene1298 1.36e-205 665.0 COG5276@1|root,COG5276@2|Bacteria,4NDUD@976|Bacteroidetes,1IYS6@117747|Sphingobacteriia 976|Bacteroidetes S cellulase activity - - - - - - - - - - - - CarboxypepD_reg,LVIVD,MAM,TSP_3,fn3 HSJS3_k127_6000877_50 861299.J421_4135 3.975e-85 306.0 COG0515@1|root,COG0515@2|Bacteria,1ZUAC@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase HSJS3_k127_6000877_99 861299.J421_0735 1.593e-38 155.0 COG0457@1|root,COG0457@2|Bacteria 861299.J421_0735|- S peptidyl-tyrosine sulfation - - - ko:K13992 - - - - ko00000,ko00194 - - - - HSJS3_k127_6000877_35 394221.Mmar10_1711 5.149e-114 380.0 COG1235@1|root,COG1235@2|Bacteria,1PVWC@1224|Proteobacteria,2V746@28211|Alphaproteobacteria,43Z2A@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Beta-lactamase superfamily domain - - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 HSJS3_k127_6000877_121 379066.GAU_3656 2.099e-24 117.0 2FBPM@1|root,343UM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_6000877_57 1089550.ATTH01000002_gene79 2.23e-75 269.0 COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,1FJT7@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P PFAM sodium calcium exchanger membrane region - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex HSJS3_k127_6000877_6 861299.J421_1048 3.511e-206 674.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 HSJS3_k127_6000877_78 1382306.JNIM01000001_gene1022 1.804e-52 190.0 COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi 200795|Chloroflexi C 2Fe-2S -binding domain protein - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 HSJS3_k127_6000877_93 1278073.MYSTI_04845 3.374e-41 168.0 COG3386@1|root,COG3386@2|Bacteria,1RE3R@1224|Proteobacteria,42SFJ@68525|delta/epsilon subdivisions,2WPY7@28221|Deltaproteobacteria,2YV98@29|Myxococcales 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - HSJS3_k127_6000877_131 1173029.JH980292_gene4196 1.346e-13 75.0 COG1826@1|root,COG1826@2|Bacteria,1G7W1@1117|Cyanobacteria,1HCWT@1150|Oscillatoriales 1117|Cyanobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 HSJS3_k127_6000877_58 1379270.AUXF01000004_gene3235 2.756e-74 259.0 COG1403@1|root,COG1403@2|Bacteria,1ZTF1@142182|Gemmatimonadetes 142182|Gemmatimonadetes L HNH nucleases - - - - - - - - - - - - HNH_5 HSJS3_k127_6000877_13 574087.Acear_1443 1.103e-159 530.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WACI@53433|Halanaerobiales 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII HSJS3_k127_6000877_96 861299.J421_1752 2.023e-40 164.0 2DWGD@1|root,3407S@2|Bacteria,1ZV24@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg HSJS3_k127_6000877_56 861299.J421_2819 4.956e-79 282.0 COG0123@1|root,COG0123@2|Bacteria,1ZSKN@142182|Gemmatimonadetes 142182|Gemmatimonadetes BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl HSJS3_k127_6000877_80 379066.GAU_2173 4.059e-50 192.0 COG0631@1|root,COG0631@2|Bacteria,1ZSYG@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 HSJS3_k127_6000877_33 861299.J421_3775 2.29e-114 388.0 COG1078@1|root,COG1078@2|Bacteria,1ZT3F@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD HSJS3_k127_6000877_89 379066.GAU_0282 1.35e-43 181.0 2EWAK@1|root,33PPB@2|Bacteria,1ZT00@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_6000877_8 713586.KB900536_gene2217 1.04e-197 650.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 HSJS3_k127_6000877_119 1121289.JHVL01000020_gene841 7.016e-25 105.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,36MMP@31979|Clostridiaceae 186801|Clostridia K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD HSJS3_k127_6000877_109 290398.Csal_2499 3.559e-33 149.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XIND@135619|Oceanospirillales 135619|Oceanospirillales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L HSJS3_k127_6000877_30 379066.GAU_1920 4.094e-119 419.0 COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec HSJS3_k127_6000877_97 1089550.ATTH01000001_gene2396 3.159e-40 158.0 COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,1FIYM@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes U MotA/TolQ/ExbB proton channel family exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB HSJS3_k127_6000877_53 1114856.C496_02722 1.162e-83 287.0 COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,23RZG@183963|Halobacteria 183963|Halobacteria E COG4608 ABC-type oligopeptide transport system, ATPase component dppF1 - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY HSJS3_k127_6000877_133 358396.C445_07225 2.99e-12 78.0 COG0613@1|root,arCOG00302@2157|Archaea,2XT0R@28890|Euryarchaeota,23SGT@183963|Halobacteria 183963|Halobacteria S metal-dependent phosphoesterases (PHP family) - - - - - - - - - - - - PHP,PHP_C HSJS3_k127_6000877_104 251221.35210651 1.508e-36 154.0 COG1670@1|root,COG1670@2|Bacteria,1G7I7@1117|Cyanobacteria 1117|Cyanobacteria J Acetyltransferase (GNAT) domain - - - ko:K03817 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 HSJS3_k127_6000877_49 1142394.PSMK_09280 3.81e-88 305.0 COG0436@1|root,COG0436@2|Bacteria 2|Bacteria E Aminotransferase - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 HSJS3_k127_6000877_55 1192034.CAP_4260 2.734e-80 284.0 COG1319@1|root,COG1319@2|Bacteria,1PG5C@1224|Proteobacteria,43EJH@68525|delta/epsilon subdivisions,2X9UI@28221|Deltaproteobacteria,2Z2GS@29|Myxococcales 28221|Deltaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 HSJS3_k127_6000877_101 1192034.CAP_5445 8.748e-38 160.0 COG0546@1|root,COG0546@2|Bacteria,1RBMZ@1224|Proteobacteria,42RG3@68525|delta/epsilon subdivisions,2WZ2N@28221|Deltaproteobacteria,2Z16Z@29|Myxococcales 28221|Deltaproteobacteria S HAD-hyrolase-like - - 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 HSJS3_k127_6000877_2 1121382.JQKG01000017_gene1834 1.41e-234 754.0 COG0466@1|root,COG0466@2|Bacteria,1WISX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C HSJS3_k127_6000877_16 861299.J421_4428 1.644e-150 487.0 COG0761@1|root,COG0761@2|Bacteria,1ZTGU@142182|Gemmatimonadetes 142182|Gemmatimonadetes C LytB protein - - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB HSJS3_k127_6000877_90 1123070.KB899249_gene437 3.704e-43 166.0 COG2267@1|root,COG2267@2|Bacteria,46WQX@74201|Verrucomicrobia,2IUN2@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Alpha/beta hydrolase family - - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 HSJS3_k127_6000877_29 861299.J421_1322 1.933e-120 402.0 COG0165@1|root,COG0165@2|Bacteria,1ZSM0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Argininosuccinate lyase C-terminal argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 HSJS3_k127_6000877_14 861299.J421_1323 4.43e-157 509.0 COG0137@1|root,COG0137@2|Bacteria,1ZTYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Arginosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth HSJS3_k127_6000877_137 945713.IALB_0149 2.353e-09 68.0 COG4911@1|root,COG4911@2|Bacteria 2|Bacteria S Uncharacterized conserved protein (DUF2203) - - - - - - - - - - - - DUF2203 HSJS3_k127_6000877_64 266117.Rxyl_2798 5.575e-67 236.0 COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4CQ7J@84995|Rubrobacteria 84995|Rubrobacteria IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 HSJS3_k127_6000877_37 1123070.KB899254_gene1284 1.274e-106 360.0 COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia,2IVU9@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 HSJS3_k127_6000877_135 388399.SSE37_12004 3.037e-10 66.0 COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG0694 Thioredoxin-like proteins and domains nifU - - - - - - - - - - - Nfu_N,NifU HSJS3_k127_6000877_28 404589.Anae109_2847 1.904e-123 410.0 COG0823@1|root,COG0823@2|Bacteria,1QW3I@1224|Proteobacteria,42YA5@68525|delta/epsilon subdivisions,2WU6I@28221|Deltaproteobacteria,2Z3J0@29|Myxococcales 28221|Deltaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 HSJS3_k127_6000877_122 247490.KSU1_D0904 6.951e-24 118.0 COG1807@1|root,COG1807@2|Bacteria,2J1H1@203682|Planctomycetes 203682|Planctomycetes M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 HSJS3_k127_6000877_103 861299.J421_4367 8.557e-37 149.0 COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX HSJS3_k127_6000877_130 1348657.M622_16440 1.138e-13 72.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,2KVI6@206389|Rhodocyclales 206389|Rhodocyclales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase HSJS3_k127_6118172_4 1408823.AXUS01000073_gene990 8.514e-07 52.0 2DR59@1|root,33A7S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_6118172_2 616991.JPOO01000003_gene640 3.075e-10 71.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia,23HX8@178469|Arenibacter 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 HSJS3_k127_6118172_3 1122194.AUHU01000002_gene2690 2.954e-09 69.0 COG0810@1|root,COG3266@1|root,COG3291@1|root,COG0810@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1T46G@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - REJ HSJS3_k127_6118172_0 929556.Solca_3116 1.737e-89 318.0 COG1835@1|root,COG1835@2|Bacteria,4NMNZ@976|Bacteroidetes,1IQXU@117747|Sphingobacteriia 976|Bacteroidetes I Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153 HSJS3_k127_6118172_1 1380394.JADL01000002_gene1116 7.571e-48 183.0 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,2JR0D@204441|Rhodospirillales 204441|Rhodospirillales C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N HSJS3_k127_6152282_2 1121948.AUAC01000005_gene2012 3.515e-42 166.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C HSJS3_k127_6152282_0 1122604.JONR01000031_gene1279 5.936e-81 298.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 HSJS3_k127_6152282_1 1122604.JONR01000031_gene1279 3.175e-42 173.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 HSJS3_k127_6381130_2 861299.J421_0488 1.194e-126 416.0 COG2223@1|root,COG2223@2|Bacteria,1ZT8I@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 HSJS3_k127_6381130_8 1128421.JAGA01000003_gene2936 2.414e-62 239.0 COG0506@1|root,COG0506@2|Bacteria,2NPED@2323|unclassified Bacteria 2|Bacteria E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh HSJS3_k127_6381130_1 543526.Htur_1862 1.078e-191 607.0 COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,23S81@183963|Halobacteria 183963|Halobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase spaT - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 HSJS3_k127_6381130_17 1218173.BALCAV_0219565 0.0002327 51.0 COG2165@1|root,COG2165@2|Bacteria,1UATR@1239|Firmicutes,4IM6K@91061|Bacilli,1ZJBF@1386|Bacillus 91061|Bacilli NU general secretion pathway protein - - - ko:K02246 - M00429 - - ko00000,ko00002,ko02044 - - - N_methyl HSJS3_k127_6381130_16 1379270.AUXF01000003_gene3669 4.541e-06 57.0 2F5SD@1|root,33YB8@2|Bacteria,1ZUXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_6381130_3 388413.ALPR1_00675 8.622e-122 413.0 COG5276@1|root,COG5276@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Big_2,DUF1566,LVIVD,Pec_lyase_C,Pectinesterase HSJS3_k127_6381130_15 1122604.JONR01000004_gene853 3.493e-13 83.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - HSJS3_k127_6381130_14 485915.Dret_0105 1.441e-17 94.0 COG1846@1|root,COG1846@2|Bacteria,1N75F@1224|Proteobacteria,42VDI@68525|delta/epsilon subdivisions,2WR80@28221|Deltaproteobacteria,2MBUI@213115|Desulfovibrionales 28221|Deltaproteobacteria K Transcriptional regulator, marR - - - - - - - - - - - - MarR HSJS3_k127_6381130_10 1379270.AUXF01000001_gene2631 1.467e-43 171.0 COG3595@1|root,COG3595@2|Bacteria,1ZTQ0@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - DUF4097 HSJS3_k127_6381130_13 1384056.N787_04785 5.244e-22 106.0 COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales 135614|Xanthomonadales S Putative adhesin - - - - - - - - - - - - DUF4097 HSJS3_k127_6381130_18 1384056.N787_04780 0.0008503 49.0 2CKCT@1|root,32SC5@2|Bacteria,1N1BJ@1224|Proteobacteria,1T6U5@1236|Gammaproteobacteria,1X85I@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - HSJS3_k127_6381130_9 1379270.AUXF01000001_gene2634 2.459e-50 185.0 COG1595@1|root,COG1595@2|Bacteria,1ZTNR@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_6381130_0 1089550.ATTH01000001_gene1843 2.36e-223 723.0 COG0531@1|root,COG0569@1|root,COG1762@1|root,COG0531@2|Bacteria,COG0569@2|Bacteria,COG1762@2|Bacteria,4NDU2@976|Bacteroidetes,1FJTH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes EGPT Amino acid permease - - - - - - - - - - - - AA_permease,AA_permease_2,PTS_EIIA_2,TrkA_C HSJS3_k127_6381130_7 443144.GM21_2570 6.929e-69 260.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,43TX0@69541|Desulfuromonadales 28221|Deltaproteobacteria J SMART Elongator protein 3 MiaB NifB mtaB - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 HSJS3_k127_6381130_5 745310.G432_13940 5.721e-90 329.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria,2K1AW@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec HSJS3_k127_6381130_4 469378.Ccur_09300 1.252e-115 385.0 COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CU9T@84998|Coriobacteriia 84998|Coriobacteriia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind,SAP HSJS3_k127_6381130_11 861299.J421_3635 5.024e-43 170.0 COG0565@1|root,COG0565@2|Bacteria,1ZT19@142182|Gemmatimonadetes 142182|Gemmatimonadetes J SpoU rRNA Methylase family - - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase HSJS3_k127_6381130_12 1047013.AQSP01000131_gene1844 3.562e-23 108.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc HSJS3_k127_6381130_6 404589.Anae109_0182 4.782e-71 261.0 COG0535@1|root,COG0535@2|Bacteria,1PCDW@1224|Proteobacteria,430T3@68525|delta/epsilon subdivisions,2WW5X@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM HSJS3_k127_640012_0 234267.Acid_3938 7.367e-32 139.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 HSJS3_k127_640012_1 1177928.TH2_04283 4.322e-26 115.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,2JPNJ@204441|Rhodospirillales 204441|Rhodospirillales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine - - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD HSJS3_k127_6924520_1 1077974.GOEFS_070_00160 5.278e-11 72.0 COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4GD5S@85026|Gordoniaceae 201174|Actinobacteria K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 HSJS3_k127_6924520_0 794903.OPIT5_07640 7.692e-26 109.0 COG0566@1|root,COG0566@2|Bacteria,46TF9@74201|Verrucomicrobia,3K7VA@414999|Opitutae 414999|Opitutae J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind HSJS3_k127_7081987_0 381666.H16_A1706 1.412e-103 380.0 COG1404@1|root,COG1404@2|Bacteria,1REVZ@1224|Proteobacteria,2WDV2@28216|Betaproteobacteria,1KB1U@119060|Burkholderiaceae 28216|Betaproteobacteria O Subtilase family - - - ko:K17734 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S8 HSJS3_k127_7081987_3 1122179.KB890464_gene356 7.393e-10 74.0 COG2133@1|root,COG2911@1|root,COG2931@1|root,COG3055@1|root,COG2133@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3055@2|Bacteria,4NHUD@976|Bacteroidetes,1IW8R@117747|Sphingobacteriia 976|Bacteroidetes G Bacterial Ig-like domain - - - - - - - - - - - - Big_5,GSDH HSJS3_k127_7081987_1 1454010.JEOE01000015_gene1130 1.187e-56 228.0 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria 201174|Actinobacteria P PFAM PKD domain containing protein wcoG - - - - - - - - - - - Laminin_G_3,PKD HSJS3_k127_7081987_2 1336208.JADY01000005_gene1969 7.255e-47 170.0 COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,2TSVI@28211|Alphaproteobacteria,2JRDZ@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the hyi family - - 5.3.1.35 ko:K22131 - - - - ko00000,ko01000 - - - AP_endonuc_2 HSJS3_k127_7493413_12 1379270.AUXF01000002_gene1290 2.259e-78 289.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase HSJS3_k127_7493413_10 330214.NIDE0740 8.945e-86 297.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 HSJS3_k127_7493413_29 478741.JAFS01000002_gene473 1.324e-09 70.0 COG0392@1|root,COG0392@2|Bacteria,46T31@74201|Verrucomicrobia,37GPN@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM HSJS3_k127_7493413_15 234267.Acid_4653 1.051e-58 220.0 COG0438@1|root,COG0438@2|Bacteria,3Y770@57723|Acidobacteria 57723|Acidobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 HSJS3_k127_7493413_9 383372.Rcas_0758 2.479e-92 316.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 HSJS3_k127_7493413_13 1500301.JQMF01000001_gene29 1.538e-76 284.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_19 HSJS3_k127_7493413_33 426355.Mrad2831_4200 1.456e-06 57.0 COG3832@1|root,COG3832@2|Bacteria,1RG8P@1224|Proteobacteria,2U8ZP@28211|Alphaproteobacteria,1JQQA@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Polyketide cyclase / dehydrase and lipid transport mxaD - - ko:K16260 ko00680,ko01120,map00680,map01120 - - - ko00000,ko00001 - - - Polyketide_cyc2 HSJS3_k127_7493413_7 1168034.FH5T_19015 1.221e-119 399.0 COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes 976|Bacteroidetes C oxidoreductase - - - - - - - - - - - - - HSJS3_k127_7493413_25 1121875.KB907548_gene1637 1.196e-20 98.0 COG0664@1|root,COG0664@2|Bacteria,4NRPE@976|Bacteroidetes 976|Bacteroidetes T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding HSJS3_k127_7493413_6 331678.Cphamn1_1855 1.895e-127 426.0 COG0493@1|root,COG0493@2|Bacteria,1FDFY@1090|Chlorobi 1090|Chlorobi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 HSJS3_k127_7493413_32 467661.RKLH11_2176 1.937e-07 58.0 2BGF0@1|root,32ACV@2|Bacteria,1RI61@1224|Proteobacteria,2U9WW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3307) - - - - - - - - - - - - DUF3307 HSJS3_k127_7493413_24 1121896.JMLU01000024_gene2516 2.192e-25 113.0 COG1959@1|root,COG1959@2|Bacteria,4NQGU@976|Bacteroidetes,1IG85@117743|Flavobacteriia,2NX1W@237|Flavobacterium 976|Bacteroidetes K Transcriptional regulator - - - - - - - - - - - - Rrf2 HSJS3_k127_7493413_3 1040989.AWZU01000035_gene1779 1.257e-197 632.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,3JT6H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Malic enzyme, NAD binding domain MA20_02490 - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic HSJS3_k127_7493413_26 335543.Sfum_2194 3.254e-17 91.0 COG0515@1|root,COG0515@2|Bacteria,1QZ10@1224|Proteobacteria 1224|Proteobacteria KLT Domain of unknown function (DUF4328) - - - - - - - - - - - - DUF4328 HSJS3_k127_7493413_14 1045855.DSC_15610 1.167e-72 252.0 COG2173@1|root,COG2173@2|Bacteria,1RENK@1224|Proteobacteria,1S3SJ@1236|Gammaproteobacteria,1X64M@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide ddpX - 3.4.13.22 ko:K08641 ko01502,ko02020,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - Peptidase_M15 HSJS3_k127_7493413_34 518766.Rmar_2301 8.892e-05 55.0 COG0457@1|root,COG0457@2|Bacteria 518766.Rmar_2301|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - HSJS3_k127_7493413_2 1379270.AUXF01000003_gene3703 2.367e-227 728.0 COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Elongation factor G C-terminus - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 HSJS3_k127_7493413_31 266762.HQ36_03225 1.602e-07 63.0 COG0322@1|root,COG0322@2|Bacteria,4NGEV@976|Bacteroidetes,2FNVF@200643|Bacteroidia,22XZM@171551|Porphyromonadaceae 976|Bacteroidetes L Domain of unknown function (DUF4837) - - - - - - - - - - - - DUF4837 HSJS3_k127_7493413_0 1379270.AUXF01000004_gene3141 0.0 1283.0 COG0587@1|root,COG0587@2|Bacteria,1ZT8N@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Helix-hairpin-helix motif - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP HSJS3_k127_7493413_8 880073.Calab_1391 2.822e-100 338.0 COG0825@1|root,COG0825@2|Bacteria,2NNVQ@2323|unclassified Bacteria 2|Bacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA,Carboxyl_trans HSJS3_k127_7493413_11 861299.J421_2654 5.358e-84 289.0 COG1774@1|root,COG1774@2|Bacteria,1ZTE8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S PSP1 C-terminal conserved region - - - - - - - - - - - - PSP1 HSJS3_k127_7493413_5 660470.Theba_0538 4.97e-134 448.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2GCDP@200918|Thermotogae 200918|Thermotogae J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind HSJS3_k127_7493413_17 880073.Calab_2383 9.01e-47 181.0 COG0739@1|root,COG0739@2|Bacteria,2NPG3@2323|unclassified Bacteria 2|Bacteria M Peptidase family M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 HSJS3_k127_7493413_4 1232410.KI421415_gene3026 8e-152 506.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MQS@68525|delta/epsilon subdivisions,2X28Y@28221|Deltaproteobacteria,43U5A@69541|Desulfuromonadales 28221|Deltaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - 3HCDH,3HCDH_N,ECH_1 HSJS3_k127_7493413_27 272844.PAB0381 1.323e-14 86.0 COG2306@1|root,arCOG05760@2157|Archaea,2XX0W@28890|Euryarchaeota,243ZF@183968|Thermococci 183968|Thermococci S Protein of unknown function (DUF402) - - - ko:K09145 - - - - ko00000 - - - DUF402 HSJS3_k127_7493413_20 1123360.thalar_00960 5.095e-38 153.0 29681@1|root,2ZTI1@2|Bacteria,1RA8W@1224|Proteobacteria,2U6CU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M50B-like - - - - - - - - - - - - Peptidase_M50B HSJS3_k127_7493413_22 414684.RC1_3923 9.707e-36 151.0 COG2199@1|root,COG3852@1|root,COG3706@2|Bacteria,COG3852@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria,2JZ9Z@204441|Rhodospirillales 204441|Rhodospirillales T diguanylate cyclase - - - - - - - - - - - - GGDEF HSJS3_k127_7493413_19 1089550.ATTH01000001_gene1178 1.146e-38 149.0 COG0454@1|root,COG0456@2|Bacteria,4NT3M@976|Bacteroidetes,1FK4C@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 HSJS3_k127_7493413_18 1273103.NM10_00814 1.692e-43 173.0 COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,4H220@909932|Negativicutes 909932|Negativicutes M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 HSJS3_k127_7493413_1 1237149.C900_05550 2.937e-272 858.0 COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia 976|Bacteroidetes EU Dipeptidyl peptidase IV (DPP IV) N-terminal region - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 HSJS3_k127_7493413_16 768671.ThimaDRAFT_1176 2.916e-50 182.0 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,1X24R@135613|Chromatiales 135613|Chromatiales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS HSJS3_k127_7493413_30 795797.C497_01650 4.276e-09 61.0 arCOG10130@1|root,arCOG10130@2157|Archaea,2XZWX@28890|Euryarchaeota,23Y13@183963|Halobacteria 183963|Halobacteria S metal-sulfur cluster biosynthetic enzyme - - - - - - - - - - - - - HSJS3_k127_7493413_21 1382306.JNIM01000001_gene267 5.375e-36 147.0 COG3396@1|root,COG3396@2|Bacteria,2G9KQ@200795|Chloroflexi 200795|Chloroflexi S PFAM phenylacetic acid catabolic family protein - - 1.14.13.149 ko:K02611 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC HSJS3_k127_7493413_28 1198232.CYCME_2337 2.486e-11 66.0 COG3460@1|root,COG3460@2|Bacteria,1ND92@1224|Proteobacteria 1224|Proteobacteria Q Phenylacetic acid degradation B - - - - - - - - - - - - PaaB HSJS3_k127_7493413_23 1218173.BALCAV_0221025 4.194e-30 123.0 COG2151@1|root,COG2151@2|Bacteria,1VE3S@1239|Firmicutes,4HKP6@91061|Bacilli,1ZI4C@1386|Bacillus 91061|Bacilli S Iron-sulfur cluster assembly protein - - - - - - - - - - - - FeS_assembly_P HSJS3_k127_7764885_0 357808.RoseRS_1205 3.027e-47 192.0 COG1572@1|root,COG1572@2|Bacteria,2G7MU@200795|Chloroflexi,374XB@32061|Chloroflexia 32061|Chloroflexia S Peptidase family C25 - - - - - - - - - - - - Peptidase_C25 HSJS3_k127_7798543_2 518766.Rmar_1908 2.146e-122 408.0 COG0733@1|root,COG0733@2|Bacteria,4P0HG@976|Bacteroidetes,1FJSG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF HSJS3_k127_7798543_6 1370125.AUWT01000052_gene4738 3.025e-16 90.0 COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,235TR@1762|Mycobacteriaceae 201174|Actinobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 HSJS3_k127_7798543_5 1463936.JOJI01000012_gene6342 1.768e-22 112.0 COG2866@1|root,COG2866@2|Bacteria,2GJ8D@201174|Actinobacteria 201174|Actinobacteria E carboxypeptidase - - - - - - - - - - - - Peptidase_M14 HSJS3_k127_7798543_3 861299.J421_2812 6.324e-57 217.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - - HSJS3_k127_7798543_1 880073.Calab_2803 1.801e-189 602.0 COG0423@1|root,COG0423@2|Bacteria,2NNN9@2323|unclassified Bacteria 2|Bacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b HSJS3_k127_7798543_4 266117.Rxyl_1999 3.915e-46 177.0 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4CQHH@84995|Rubrobacteria 84995|Rubrobacteria C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD HSJS3_k127_7798543_0 234267.Acid_6465 4.67e-209 685.0 COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria 57723|Acidobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug HSJS3_k127_7842310_2 379066.GAU_1554 7.167e-115 379.0 COG0195@1|root,COG0195@2|Bacteria,1ZSNN@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N HSJS3_k127_7842310_8 379066.GAU_1553 7.853e-21 98.0 COG0779@1|root,COG0779@2|Bacteria,1ZTX3@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C HSJS3_k127_7842310_5 278963.ATWD01000001_gene4271 7.14e-30 128.0 COG1496@1|root,COG1496@2|Bacteria,3Y3J1@57723|Acidobacteria,2JHKU@204432|Acidobacteriia 204432|Acidobacteriia S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 HSJS3_k127_7842310_1 288000.BBta_0011 8.568e-166 534.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,3JVEC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase HSJS3_k127_7842310_6 1123274.KB899427_gene3350 1.469e-22 109.0 COG1762@1|root,COG1762@2|Bacteria 2|Bacteria G phosphoenolpyruvate-dependent sugar phosphotransferase system ptsN3 - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K02806 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2 HSJS3_k127_7842310_7 555088.DealDRAFT_0428 1.907e-22 101.0 COG0347@1|root,COG0347@2|Bacteria,1VFZ7@1239|Firmicutes,25F61@186801|Clostridia 186801|Clostridia K Belongs to the P(II) protein family - - - - - - - - - - - - P-II HSJS3_k127_7842310_3 861299.J421_3181 4.771e-77 277.0 28Q1P@1|root,2ZB8E@2|Bacteria,1ZSPA@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Zinc dependent phospholipase C - - - - - - - - - - - - Zn_dep_PLPC HSJS3_k127_7842310_0 1379270.AUXF01000005_gene811 7.941e-194 629.0 COG0210@1|root,COG0210@2|Bacteria,1ZTD5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C HSJS3_k127_7842310_4 1379270.AUXF01000005_gene810 3.222e-68 243.0 COG5000@1|root,COG5000@2|Bacteria,1ZSKZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c HSJS3_k127_8035615_16 861299.J421_2409 2.274e-14 78.0 COG1845@1|root,COG1845@2|Bacteria,1ZT8Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c oxidase subunit III - - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 HSJS3_k127_8035615_2 1379270.AUXF01000002_gene1826 2.792e-244 767.0 COG0843@1|root,COG0843@2|Bacteria,1ZSMG@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 HSJS3_k127_8035615_7 479434.Sthe_1582 7.729e-97 329.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi,27XKX@189775|Thermomicrobia 189775|Thermomicrobia C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C HSJS3_k127_8035615_4 986075.CathTA2_0968 5.162e-140 464.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,4H9YY@91061|Bacilli 91061|Bacilli F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS HSJS3_k127_8035615_10 518766.Rmar_1872 2.75e-51 190.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1FITI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N HSJS3_k127_8035615_6 246194.CHY_1803 2.53e-102 351.0 COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,42F61@68295|Thermoanaerobacterales 186801|Clostridia J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA - 2.9.1.1,4.3.1.29 ko:K01042,ko:K17468 ko00030,ko00450,ko00970,ko01120,map00030,map00450,map00970,map01120 - R08219,R10408 RC00544,RC01246 ko00000,ko00001,ko01000 - - - Se-cys_synth_N,SelA HSJS3_k127_8035615_14 379066.GAU_1282 4.012e-27 125.0 COG2372@1|root,COG2372@2|Bacteria,1ZTUI@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 HSJS3_k127_8035615_1 401526.TcarDRAFT_1704 5.7e-313 982.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,4H21Q@909932|Negativicutes 909932|Negativicutes J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 HSJS3_k127_8035615_5 861299.J421_3701 2.499e-112 376.0 COG0436@1|root,COG0436@2|Bacteria,1ZTCU@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Aminotransferase class I and II - - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 HSJS3_k127_8035615_3 379066.GAU_1255 1.564e-143 481.0 2CD20@1|root,2Z7SQ@2|Bacteria,1ZTFE@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8035615_17 861299.J421_2978 1.072e-10 75.0 COG1729@1|root,COG1729@2|Bacteria,1ZTBJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - - HSJS3_k127_8035615_8 861299.J421_2977 7.838e-69 266.0 COG1196@1|root,COG4942@1|root,COG1196@2|Bacteria,COG4942@2|Bacteria,1ZSU8@142182|Gemmatimonadetes 142182|Gemmatimonadetes D nuclear chromosome segregation - - - - - - - - - - - - - HSJS3_k127_8035615_9 861299.J421_2975 4.233e-63 228.0 COG0313@1|root,COG0313@2|Bacteria,1ZTK1@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase HSJS3_k127_8035615_12 379066.GAU_1250 8.696e-34 134.0 COG3118@1|root,COG3118@2|Bacteria,1ZTS0@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Thioredoxin-like domain - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin HSJS3_k127_8035615_13 443144.GM21_0571 4.809e-33 132.0 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase mceE - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 HSJS3_k127_8035615_18 861299.J421_2972 2.959e-05 54.0 28ZEQ@1|root,2ZM6A@2|Bacteria,1ZU2C@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8035615_0 379066.GAU_1492 0.0 1075.0 COG0542@1|root,COG0542@2|Bacteria,1ZT9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N HSJS3_k127_8035615_15 518766.Rmar_1296 7.134e-16 85.0 COG0071@1|root,COG0071@2|Bacteria 2|Bacteria O Belongs to the small heat shock protein (HSP20) family hspA - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 HSJS3_k127_8035615_11 379066.GAU_3855 1.83e-40 159.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE HSJS3_k127_8038682_0 1192034.CAP_2960 3.56e-62 219.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42RF2@68525|delta/epsilon subdivisions,2WP05@28221|Deltaproteobacteria,2YWCM@29|Myxococcales 28221|Deltaproteobacteria F Amidohydrolase family allB - 3.5.2.5 ko:K01466 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02425 RC00680 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 HSJS3_k127_8048150_16 639030.JHVA01000001_gene2022 8.631e-58 211.0 COG3794@1|root,COG3794@2|Bacteria,3Y4C0@57723|Acidobacteria,2JJME@204432|Acidobacteriia 204432|Acidobacteriia C Polysaccharide lyase family 4, domain II - - - - - - - - - - - - CarboxypepD_reg HSJS3_k127_8048150_9 247490.KSU1_B0265 3.624e-89 312.0 COG2010@1|root,COG2010@2|Bacteria,2IZN4@203682|Planctomycetes 203682|Planctomycetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3,EB_dh HSJS3_k127_8048150_14 1049564.TevJSym_ac00580 4.126e-64 237.0 COG2010@1|root,COG2010@2|Bacteria,1R28S@1224|Proteobacteria,1T5JD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_CBB3 HSJS3_k127_8048150_39 1121918.ARWE01000001_gene593 1.875e-08 64.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria,43T32@69541|Desulfuromonadales 28221|Deltaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.10.3.10,1.9.3.1 ko:K02275,ko:K02297 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6 - - COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3 HSJS3_k127_8048150_1 330214.NIDE0901 2.436e-168 550.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 HSJS3_k127_8048150_7 247490.KSU1_C1314 2.768e-102 347.0 COG0535@1|root,COG0535@2|Bacteria,2J2KS@203682|Planctomycetes 203682|Planctomycetes S Proto-chlorophyllide reductase 57 kD subunit - - - - - - - - - - - - PCP_red,Radical_SAM,SPASM HSJS3_k127_8048150_13 1049564.TevJSym_ac00650 1.344e-75 279.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - Usp HSJS3_k127_8048150_37 1235800.C819_01643 6.301e-14 81.0 COG1266@1|root,COG1266@2|Bacteria,1VKKZ@1239|Firmicutes,25IZ5@186801|Clostridia,27RGT@186928|unclassified Lachnospiraceae 186801|Clostridia S CAAX protease self-immunity - - - - - - - - - - - - Abi HSJS3_k127_8048150_47 266117.Rxyl_0423 9.145e-05 53.0 COG0842@1|root,COG0842@2|Bacteria 2|Bacteria V Transport permease protein yhhJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 HSJS3_k127_8048150_31 2055.JNXA01000043_gene4205 2.486e-30 132.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4GCJD@85026|Gordoniaceae 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 HSJS3_k127_8048150_38 309807.SRU_0241 4.14e-09 64.0 COG1141@1|root,COG1141@2|Bacteria,4PF9R@976|Bacteroidetes,1FKC0@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 4Fe-4S single cluster domain of Ferredoxin I - - - - - - - - - - - - - HSJS3_k127_8048150_17 1131269.AQVV01000011_gene2523 1.234e-55 206.0 COG0489@1|root,COG0489@2|Bacteria 2|Bacteria D protein tyrosine kinase activity - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA HSJS3_k127_8048150_43 1189619.pgond44_02153 2.391e-07 60.0 2DBWZ@1|root,2ZBKJ@2|Bacteria,4NMS8@976|Bacteroidetes,1I1GJ@117743|Flavobacteriia 976|Bacteroidetes S HmuY protein - - - - - - - - - - - - HmuY HSJS3_k127_8048150_3 765952.PUV_07030 1.213e-155 520.0 COG0488@1|root,COG0488@2|Bacteria,2JGPC@204428|Chlamydiae 204428|Chlamydiae S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn HSJS3_k127_8048150_19 1267534.KB906759_gene1927 4.008e-51 205.0 COG0590@1|root,COG0590@2|Bacteria,3Y4ZN@57723|Acidobacteria,2JJC3@204432|Acidobacteriia 204432|Acidobacteriia FJ PFAM CMP dCMP deaminase zinc-binding - - - - - - - - - - - - dCMP_cyt_deam_1 HSJS3_k127_8048150_0 926566.Terro_0850 7.93e-225 718.0 COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria 57723|Acidobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 HSJS3_k127_8048150_25 1254432.SCE1572_35130 8.351e-40 155.0 COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42RRP@68525|delta/epsilon subdivisions,2WP0I@28221|Deltaproteobacteria,2Z3A6@29|Myxococcales 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518,ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103,R11168 RC00143,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Fer2_2 HSJS3_k127_8048150_21 502025.Hoch_5969 1.563e-49 187.0 COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,42R7J@68525|delta/epsilon subdivisions,2WMT4@28221|Deltaproteobacteria,2Z0Y2@29|Myxococcales 28221|Deltaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.17.1.4 ko:K13479 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 HSJS3_k127_8048150_2 215803.DB30_1345 5.878e-166 534.0 COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the HpcH HpaI aldolase family - - - - - - - - - - - - HpcH_HpaI HSJS3_k127_8048150_15 268739.Nmlp_1069 4.484e-58 226.0 COG0589@1|root,arCOG00449@2157|Archaea,2Y8DA@28890|Euryarchaeota,24193@183963|Halobacteria 183963|Halobacteria T Universal stress protein family - - - - - - - - - - - - Usp HSJS3_k127_8048150_45 267747.PPA2179 1.508e-06 61.0 COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria,4DN3N@85009|Propionibacteriales 201174|Actinobacteria P TrkA-C domain - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger,TrkA_C HSJS3_k127_8048150_11 911045.PSE_5019 1.626e-78 289.0 2CK9T@1|root,2Z7W9@2|Bacteria,1NEP3@1224|Proteobacteria,2U3MN@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8048150_5 1123518.ARWI01000001_gene468 2.031e-124 410.0 COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,1RRV4@1236|Gammaproteobacteria,46248@72273|Thiotrichales 72273|Thiotrichales S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N HSJS3_k127_8048150_30 28042.GU90_05015 3.234e-31 126.0 COG2351@1|root,COG2351@2|Bacteria,2IQUN@201174|Actinobacteria,4E5V4@85010|Pseudonocardiales 201174|Actinobacteria S Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily uraH - 3.5.2.17 ko:K07127 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R06601 RC03393 ko00000,ko00001,ko00002,ko01000,ko02000 9.B.35.1.2,9.B.35.2 - - Transthyretin HSJS3_k127_8048150_24 483219.LILAB_16830 1.396e-41 159.0 COG3195@1|root,COG3195@2|Bacteria,1RIGR@1224|Proteobacteria,438E6@68525|delta/epsilon subdivisions,2X3PB@28221|Deltaproteobacteria,2YWR6@29|Myxococcales 28221|Deltaproteobacteria S OHCU decarboxylase - - 4.1.1.97 ko:K16840 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R06604 RC01551 ko00000,ko00001,ko00002,ko01000 - - - OHCU_decarbox HSJS3_k127_8048150_6 448385.sce5877 2.493e-104 349.0 COG3195@1|root,COG4266@1|root,COG3195@2|Bacteria,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,42YE0@68525|delta/epsilon subdivisions,2X30N@28221|Deltaproteobacteria,2YTWS@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the allantoicase family alc - 3.5.3.4 ko:K01477 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02422 RC00379,RC00712 ko00000,ko00001,ko00002,ko01000 - - - Allantoicase,OHCU_decarbox HSJS3_k127_8048150_4 1192034.CAP_2960 3.396e-143 468.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42RF2@68525|delta/epsilon subdivisions,2WP05@28221|Deltaproteobacteria,2YWCM@29|Myxococcales 28221|Deltaproteobacteria F Amidohydrolase family allB - 3.5.2.5 ko:K01466 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02425 RC00680 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 HSJS3_k127_8048150_41 1415778.JQMM01000001_gene2084 3.467e-08 60.0 2DU2E@1|root,33NN7@2|Bacteria,1P5P1@1224|Proteobacteria,1SV3F@1236|Gammaproteobacteria,1JBM0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8048150_40 1191299.AJYX01000024_gene2778 2.771e-08 59.0 2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8048150_34 861299.J421_2118 1.916e-23 108.0 COG5549@1|root,COG5549@2|Bacteria,1ZTQC@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Matrixin - - - - - - - - - - - - Peptidase_M10 HSJS3_k127_8048150_23 926550.CLDAP_33530 7.328e-44 168.0 COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi 200795|Chloroflexi S PFAM Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans HSJS3_k127_8048150_27 379066.GAU_1722 3.291e-37 161.0 COG1413@1|root,COG1413@2|Bacteria,1ZUI4@142182|Gemmatimonadetes 142182|Gemmatimonadetes C HEAT repeats - - - - - - - - - - - - HEAT_2 HSJS3_k127_8048150_8 1379270.AUXF01000006_gene169 4.039e-95 339.0 COG2206@1|root,COG2206@2|Bacteria,1ZUTT@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD HSJS3_k127_8048150_20 880073.Calab_0866 1.248e-50 192.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity luxD - 3.2.1.4,4.2.99.18 ko:K01179,ko:K06889,ko:K10773,ko:K15853 ko00500,ko01100,ko02020,ko02024,ko03410,map00500,map01100,map02020,map02024,map03410 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko03400 - GH5,GH9 - Abhydrolase_1,Acyl_transf_2,DLH,Hydrolase_4,Peptidase_S9 HSJS3_k127_8048150_42 1550073.JROH01000011_gene2118 4.147e-08 65.0 COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,2UK7M@28211|Alphaproteobacteria,2K6RI@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like domain - - - - - - - - - - - - DUF4440,SnoaL_3 HSJS3_k127_8048150_22 880073.Calab_0511 7.807e-48 183.0 COG4221@1|root,COG4221@2|Bacteria,2NPJV@2323|unclassified Bacteria 2|Bacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short HSJS3_k127_8048150_33 861299.J421_2112 1.793e-23 111.0 COG2151@1|root,COG2151@2|Bacteria,1ZTUD@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Iron-sulfur cluster assembly protein - - - - - - - - - - - - FeS_assembly_P HSJS3_k127_8048150_32 1121396.KB893112_gene1999 1.18e-23 105.0 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,42VMT@68525|delta/epsilon subdivisions,2WPFB@28221|Deltaproteobacteria,2MK8N@213118|Desulfobacterales 28221|Deltaproteobacteria S FxsA cytoplasmic membrane protein fsxA - - ko:K07113 - - - - ko00000 - - - FxsA HSJS3_k127_8048150_35 288705.RSal33209_3076 6.565e-23 105.0 COG2259@1|root,COG2259@2|Bacteria,2IQ5C@201174|Actinobacteria,1W9YU@1268|Micrococcaceae 201174|Actinobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX HSJS3_k127_8048150_29 1379698.RBG1_1C00001G0796 2.034e-32 131.0 COG1956@1|root,COG1956@2|Bacteria 2|Bacteria T GAF domain-containing protein yebR - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 HSJS3_k127_8048150_10 1128421.JAGA01000001_gene2365 1.048e-82 288.0 COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria 2|Bacteria C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 HSJS3_k127_8048150_12 118163.Ple7327_1962 9.137e-78 268.0 COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,3VI7V@52604|Pleurocapsales 1117|Cyanobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD HSJS3_k127_8048150_18 211165.AJLN01000081_gene995 2.346e-55 209.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1GIVV@1117|Cyanobacteria,1JJ9F@1189|Stigonemataceae 1117|Cyanobacteria S Peptidase family M50 - - - - - - - - - - - - CBS,Peptidase_M50 HSJS3_k127_8048150_28 1380350.JIAP01000007_gene2554 6.721e-33 137.0 COG1853@1|root,COG2267@1|root,COG1853@2|Bacteria,COG2267@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,43KYI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I flavin reductase ntaB - - - - - - - - - - - Abhydrolase_1,Flavin_Reduct HSJS3_k127_8048150_26 1191523.MROS_1735 2.012e-38 148.0 COG0733@1|root,COG0733@2|Bacteria 2|Bacteria S neurotransmitter:sodium symporter activity CP_0468 - - ko:K03308,ko:K03466 - - - - ko00000,ko03036 2.A.22.4,2.A.22.5,3.A.12 - - SNF HSJS3_k127_8098753_2 59894.ENSFALP00000000639 0.00011 53.0 KOG1072@1|root,KOG1072@2759|Eukaryota,390AJ@33154|Opisthokonta,3BE5D@33208|Metazoa,3CZ6Y@33213|Bilateria,48A8T@7711|Chordata,48YQ8@7742|Vertebrata,4GP5D@8782|Aves 33208|Metazoa S Kelch domain-containing protein 8A KLHDC8A GO:0000151,GO:0005575,GO:0005622,GO:0005623,GO:0031461,GO:0031463,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1990234 - - - - - - - - - - Kelch_1 HSJS3_k127_8098753_0 379066.GAU_1920 1.942e-113 401.0 COG1629@1|root,COG4771@2|Bacteria,1ZST4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P CarboxypepD_reg-like domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarboxypepD_reg,Plug,TonB_dep_Rec HSJS3_k127_8103531_0 497964.CfE428DRAFT_1013 3.632e-83 288.0 COG0053@1|root,COG0053@2|Bacteria,46SPJ@74201|Verrucomicrobia 74201|Verrucomicrobia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer HSJS3_k127_8103531_2 1337936.IJ00_09385 1.483e-12 71.0 COG2329@1|root,COG2329@2|Bacteria,1GFR9@1117|Cyanobacteria 1117|Cyanobacteria S Antibiotic biosynthesis monooxygenase - - 1.14.99.57 ko:K21481 - - - - ko00000,ko01000 - - - ABM HSJS3_k127_8103531_1 794903.OPIT5_09215 6.255e-14 74.0 COG3317@1|root,COG3317@2|Bacteria 2|Bacteria M Gram-negative-bacterium-type cell outer membrane assembly - - 3.1.6.13 ko:K01136,ko:K07287 ko00531,ko01100,ko04142,map00531,map01100,map04142 M00076,M00078 R07812,R07821 - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.33.1 - - Lipoprotein_18,SASA HSJS3_k127_8160373_2 246197.MXAN_6633 5.601e-60 231.0 28HUE@1|root,2Z815@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_8160373_4 1356852.N008_14080 3.963e-31 141.0 COG3011@1|root,COG3011@2|Bacteria,4NQ93@976|Bacteroidetes,47R74@768503|Cytophagia 976|Bacteroidetes S Protein of unknown function, DUF393 - - - - - - - - - - - - DUF393 HSJS3_k127_8160373_8 502025.Hoch_2192 2.544e-20 96.0 COG0824@1|root,COG0824@2|Bacteria,1Q2J2@1224|Proteobacteria,433TX@68525|delta/epsilon subdivisions,2X3FR@28221|Deltaproteobacteria,2YVWT@29|Myxococcales 28221|Deltaproteobacteria S Thioesterase-like superfamily - - 3.1.2.23 ko:K01075 ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120 - R01301 RC00004,RC00174 ko00000,ko00001,ko01000 - - - 4HBT HSJS3_k127_8160373_0 935863.AWZR01000005_gene2169 4.42e-103 347.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,1RQA1@1236|Gammaproteobacteria,1XC3M@135614|Xanthomonadales 135614|Xanthomonadales S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red HSJS3_k127_8160373_5 1123504.JQKD01000006_gene1535 3.656e-26 115.0 29CEM@1|root,2ZZD2@2|Bacteria,1RB3W@1224|Proteobacteria,2VT9S@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8160373_9 314285.KT71_04550 2.801e-19 98.0 2EMUX@1|root,33FH7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_8160373_7 1250232.JQNJ01000001_gene1256 6.548e-24 109.0 2ESJ3@1|root,33K3T@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - ABM HSJS3_k127_8160373_3 861299.J421_0602 3.95e-36 149.0 28RT4@1|root,2ZE5G@2|Bacteria,1ZV80@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8160373_6 566466.NOR53_347 1.675e-25 113.0 29CEM@1|root,2ZZD2@2|Bacteria,1RKJK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8160373_15 1121875.KB907547_gene3035 0.0006945 49.0 2EM9G@1|root,33EYK@2|Bacteria,4P33X@976|Bacteroidetes,1I90G@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_8160373_13 1385935.N836_03240 7.814e-07 57.0 2EM9G@1|root,33EYK@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_8160373_12 314285.KT71_13070 3.876e-08 63.0 2ECN7@1|root,336K3@2|Bacteria,1NSVS@1224|Proteobacteria,1SN3V@1236|Gammaproteobacteria,1J85Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8160373_1 1502724.FF80_03461 1.389e-69 251.0 COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase HSJS3_k127_8225660_0 1300345.LF41_1864 7.511e-30 135.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 HSJS3_k127_8225660_1 1300345.LF41_2649 1.301e-21 101.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales 135614|Xanthomonadales T Adenylate cyclase - - - - - - - - - - - - - HSJS3_k127_8232710_1 682795.AciX8_4675 9.969e-12 71.0 COG1957@1|root,COG1957@2|Bacteria,3Y5WG@57723|Acidobacteria,2JM0V@204432|Acidobacteriia 57723|Acidobacteria M PFAM Inosine uridine-preferring nucleoside hydrolase domain - - - - - - - - - - - - IU_nuc_hydro HSJS3_k127_8232710_0 682795.AciX8_4675 2.472e-50 187.0 COG1957@1|root,COG1957@2|Bacteria,3Y5WG@57723|Acidobacteria,2JM0V@204432|Acidobacteriia 57723|Acidobacteria M PFAM Inosine uridine-preferring nucleoside hydrolase domain - - - - - - - - - - - - IU_nuc_hydro HSJS3_k127_8394178_46 861299.J421_3986 6.543e-14 78.0 COG4968@1|root,COG4968@2|Bacteria 2|Bacteria NU Prokaryotic N-terminal methylation motif pilE - - ko:K02456,ko:K02650,ko:K02655 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - ComP_DUS,N_methyl HSJS3_k127_8394178_29 1242864.D187_007063 1.061e-45 189.0 COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,42WPS@68525|delta/epsilon subdivisions,2X8PP@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions S Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO HSJS3_k127_8394178_34 886293.Sinac_3585 8.5e-42 173.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - ko:K14340 - - - - ko00000,ko01000,ko01003 - - - PMT_2 HSJS3_k127_8394178_25 886293.Sinac_3585 1.118e-67 252.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - ko:K14340 - - - - ko00000,ko01000,ko01003 - - - PMT_2 HSJS3_k127_8394178_18 357808.RoseRS_4447 1.071e-89 306.0 COG0463@1|root,COG0463@2|Bacteria,2G5JH@200795|Chloroflexi,3768U@32061|Chloroflexia 32061|Chloroflexia M Glycosyltransferase like family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 HSJS3_k127_8394178_48 1112216.JH594425_gene1137 3.165e-09 70.0 COG1807@1|root,COG1807@2|Bacteria,1Q75Q@1224|Proteobacteria,2VDA2@28211|Alphaproteobacteria,2K93E@204457|Sphingomonadales 204457|Sphingomonadales M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - HSJS3_k127_8394178_36 1382356.JQMP01000004_gene167 7.688e-40 169.0 COG1287@1|root,COG1287@2|Bacteria,2G75T@200795|Chloroflexi,27XID@189775|Thermomicrobia 189775|Thermomicrobia S Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 HSJS3_k127_8394178_50 314345.SPV1_14099 5.486e-07 57.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane - - - ko:K02457,ko:K02458,ko:K08084 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15,3.A.15.2 - - GspH,N_methyl HSJS3_k127_8394178_14 861299.J421_3981 3.554e-107 357.0 COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 HSJS3_k127_8394178_43 379066.GAU_2517 2.045e-18 93.0 COG3166@1|root,COG3166@2|Bacteria,1ZTR8@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Fimbrial assembly protein (PilN) - - - - - - - - - - - - PilN HSJS3_k127_8394178_51 177439.DP0110 2.25e-05 54.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,42S1V@68525|delta/epsilon subdivisions,2WNDR@28221|Deltaproteobacteria,2MJVB@213118|Desulfobacterales 28221|Deltaproteobacteria NU PFAM Pilus assembly protein PilO pilO - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO HSJS3_k127_8394178_47 379066.GAU_2515 8.221e-11 74.0 2F6AC@1|root,33YU1@2|Bacteria,1ZTY6@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8394178_15 861299.J421_3976 2.568e-92 325.0 COG4796@1|root,COG4796@2|Bacteria,1ZSRT@142182|Gemmatimonadetes 142182|Gemmatimonadetes U AMIN domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,Secretin,Secretin_N HSJS3_k127_8394178_7 861299.J421_3974 3.113e-130 427.0 COG0082@1|root,COG0082@2|Bacteria,1ZT39@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt HSJS3_k127_8394178_38 861299.J421_3973 3.929e-32 131.0 COG0703@1|root,COG0703@2|Bacteria,1ZTXW@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI HSJS3_k127_8394178_0 118168.MC7420_4610 1.451e-262 835.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1G092@1117|Cyanobacteria,1H78E@1150|Oscillatoriales 1117|Cyanobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt HSJS3_k127_8394178_6 1329516.JPST01000063_gene1784 6.795e-144 477.0 COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,4HB27@91061|Bacilli,27BG8@186824|Thermoactinomycetaceae 91061|Bacilli J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA HSJS3_k127_8394178_27 671143.DAMO_0070 8.313e-60 228.0 COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria 2|Bacteria L Phage integrase, N-terminal SAM-like domain xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase HSJS3_k127_8394178_13 404589.Anae109_2522 4.63e-114 379.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,42QM6@68525|delta/epsilon subdivisions,2WK2P@28221|Deltaproteobacteria,2YU3I@29|Myxococcales 28221|Deltaproteobacteria H The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C HSJS3_k127_8394178_30 861299.J421_3956 4.587e-44 168.0 COG0521@1|root,COG0521@2|Bacteria,1ZU2Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Probable molybdopterin binding domain - - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth HSJS3_k127_8394178_9 861299.J421_3955 6.178e-127 428.0 COG2204@1|root,COG2204@2|Bacteria,1ZSWY@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Sigma54_activat HSJS3_k127_8394178_41 861299.J421_3859 7.222e-21 102.0 2F4EZ@1|root,33X55@2|Bacteria,1ZTSQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8394178_33 861299.J421_3858 4.176e-42 162.0 COG0218@1|root,COG0218@2|Bacteria,1ZTHF@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 HSJS3_k127_8394178_5 796606.BMMGA3_12720 1.069e-179 571.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,4H9U4@91061|Bacilli,1ZANE@1386|Bacillus 91061|Bacilli O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX HSJS3_k127_8394178_21 41431.PCC8801_2924 1.605e-78 270.0 COG0740@1|root,COG0740@2|Bacteria,1G1TB@1117|Cyanobacteria,3KFU0@43988|Cyanothece 1117|Cyanobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP2 - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease HSJS3_k127_8394178_35 273526.SMDB11_0341 2.837e-40 165.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,4019Z@613|Serratia 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N HSJS3_k127_8394178_17 379066.GAU_2377 1.179e-90 317.0 COG0265@1|root,COG0265@2|Bacteria,1ZTG6@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 HSJS3_k127_8394178_1 525904.Tter_1750 2.561e-254 799.0 COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria 2|Bacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 HSJS3_k127_8394178_20 404589.Anae109_1579 7.318e-82 282.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales 28221|Deltaproteobacteria S Rhomboid family - - - - - - - - - - - - Rhomboid HSJS3_k127_8394178_12 743721.Psesu_0508 3.891e-123 422.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1X3AE@135614|Xanthomonadales 135614|Xanthomonadales F Na dependent nucleoside transporter yeiM - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N HSJS3_k127_8394178_22 861299.J421_3835 1.41e-75 263.0 COG0005@1|root,COG0005@2|Bacteria,1ZTGZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 HSJS3_k127_8394178_24 1111069.TCCBUS3UF1_13420 1.711e-69 256.0 COG0351@1|root,COG0351@2|Bacteria,1WIN0@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin HSJS3_k127_8394178_31 1120971.AUCA01000035_gene2799 4.101e-43 167.0 COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,4HCF5@91061|Bacilli,278S4@186823|Alicyclobacillaceae 91061|Bacilli J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind HSJS3_k127_8394178_28 379066.GAU_2351 2.316e-52 194.0 COG1989@1|root,COG1989@2|Bacteria,1ZT9K@142182|Gemmatimonadetes 142182|Gemmatimonadetes NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 HSJS3_k127_8394178_19 694440.JOMF01000009_gene672 3.845e-84 297.0 COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia 224756|Methanomicrobia S CBS domain containing protein - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 HSJS3_k127_8394178_10 861299.J421_3951 6.76e-127 417.0 COG0714@1|root,COG0714@2|Bacteria,1ZT5U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 HSJS3_k127_8394178_49 861299.J421_3949 3.616e-07 55.0 2DFBE@1|root,2ZR6K@2|Bacteria,1ZU7V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 HSJS3_k127_8394178_26 379066.GAU_2490 1.19e-66 242.0 COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A HSJS3_k127_8394178_44 1410608.JNKX01000015_gene2374 6.063e-16 81.0 COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,2FTSZ@200643|Bacteroidia,4ARQC@815|Bacteroidaceae 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C HSJS3_k127_8394178_40 861299.J421_3945 2.67e-28 125.0 COG0711@1|root,COG0711@2|Bacteria,1ZTPY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B HSJS3_k127_8394178_39 861299.J421_3944 2.157e-28 124.0 COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP HSJS3_k127_8394178_2 861299.J421_2627 1.149e-227 716.0 COG0056@1|root,COG0056@2|Bacteria,1ZSNY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N HSJS3_k127_8394178_16 861299.J421_2628 8.836e-91 306.0 COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt HSJS3_k127_8394178_3 639282.DEFDS_1886 9.198e-226 707.0 COG0055@1|root,COG0055@2|Bacteria,2GEQN@200930|Deferribacteres 200930|Deferribacteres C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N HSJS3_k127_8394178_45 861299.J421_2630 1.605e-14 83.0 COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N HSJS3_k127_8394178_32 634497.HAH_2625 2.962e-42 166.0 COG0352@1|root,arCOG01089@2157|Archaea,2XSTA@28890|Euryarchaeota,23U3A@183963|Halobacteria 183963|Halobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI HSJS3_k127_8394178_23 1379270.AUXF01000004_gene3216 2.525e-70 256.0 COG1559@1|root,COG1559@2|Bacteria,1ZTA7@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG HSJS3_k127_8394178_42 760568.Desku_2022 1.984e-19 94.0 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,2622P@186807|Peptococcaceae 186801|Clostridia J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX HSJS3_k127_8394178_52 1232410.KI421424_gene1753 0.0001415 48.0 COG4980@1|root,COG4980@2|Bacteria,1NEPD@1224|Proteobacteria,42WE2@68525|delta/epsilon subdivisions,2WRDT@28221|Deltaproteobacteria,43SRZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S YtxH-like protein - - - - - - - - - - - - YtxH HSJS3_k127_8394178_8 404589.Anae109_0662 6.66e-129 427.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales 28221|Deltaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis pdp - 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C HSJS3_k127_8394178_4 379066.GAU_0644 7.281e-181 592.0 COG5009@1|root,COG5009@2|Bacteria,1ZT3R@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase HSJS3_k127_8394178_11 518766.Rmar_1034 1.018e-123 411.0 COG0162@1|root,COG0162@2|Bacteria,4NF19@976|Bacteroidetes,1FINY@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b HSJS3_k127_8394178_37 945713.IALB_1169 2.118e-36 148.0 COG1629@1|root,COG4772@1|root,COG4771@2|Bacteria,COG4772@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec HSJS3_k127_8486752_0 5911.EAR89871 9.933e-05 52.0 COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota 2759|Eukaryota O protein N-acetylglucosaminyltransferase activity - - 2.4.1.255 ko:K09667 ko00514,ko04931,map00514,map04931 - R09304,R09676 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003,ko03036 - GT41 - TPR_8 HSJS3_k127_8652860_7 861299.J421_3369 9.755e-32 132.0 COG0101@1|root,COG0101@2|Bacteria,1ZSRZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 HSJS3_k127_8652860_6 379066.GAU_1730 4.778e-85 301.0 COG0265@1|root,COG0265@2|Bacteria,1ZTAM@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 HSJS3_k127_8652860_3 379066.GAU_1731 3.904e-148 482.0 COG0015@1|root,COG0015@2|Bacteria,1ZSVW@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Adenylosuccinate lyase C-terminus - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 HSJS3_k127_8652860_4 1205680.CAKO01000041_gene5517 2.434e-109 363.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TS0T@28211|Alphaproteobacteria,2JPCI@204441|Rhodospirillales 204441|Rhodospirillales F SAICAR synthetase - - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt HSJS3_k127_8652860_8 570967.JMLV01000001_gene2909 1.063e-15 83.0 COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2JTEV@204441|Rhodospirillales 204441|Rhodospirillales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS HSJS3_k127_8652860_5 861299.J421_3378 5.184e-87 293.0 COG0047@1|root,COG0047@2|Bacteria,1ZTF8@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 HSJS3_k127_8652860_0 1379270.AUXF01000006_gene153 4.317e-261 826.0 COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C HSJS3_k127_8652860_2 671143.DAMO_1501 6.422e-156 506.0 COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria 2|Bacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iSB619.SA_RS05225 GATase_6,GATase_7,Pribosyltran HSJS3_k127_8652860_1 653733.Selin_0781 6.272e-210 668.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria 2|Bacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ppdK - 2.7.3.13,2.7.9.1 ko:K01006,ko:K22424 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N HSJS3_k127_8654431_15 861299.J421_3987 2.623e-169 542.0 COG2204@1|root,COG2204@2|Bacteria,1ZSRQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat HSJS3_k127_8654431_36 1379270.AUXF01000003_gene3385 2.263e-84 303.0 COG3852@1|root,COG3852@2|Bacteria,1ZSYP@142182|Gemmatimonadetes 142182|Gemmatimonadetes T PAS domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA HSJS3_k127_8654431_21 379066.GAU_2568 1.329e-147 480.0 COG1459@1|root,COG1459@2|Bacteria,1ZT63@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Type II secretion system (T2SS), protein F - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF HSJS3_k127_8654431_18 379066.GAU_2569 7.377e-161 515.0 COG2805@1|root,COG2805@2|Bacteria,1ZSQE@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE HSJS3_k127_8654431_8 861299.J421_4158 1.267e-222 705.0 COG2804@1|root,COG2804@2|Bacteria,1ZSSN@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N HSJS3_k127_8654431_79 660470.Theba_0520 1.38e-20 100.0 COG1555@1|root,COG1555@2|Bacteria,2GD8U@200918|Thermotogae 200918|Thermotogae L TIGRFAM competence protein ComEA helix-hairpin-helix repeat - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 HSJS3_k127_8654431_13 1379270.AUXF01000001_gene2822 6.638e-173 607.0 COG4797@1|root,COG4797@2|Bacteria 2|Bacteria - - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - - - - - - - - - - Glyco_transf_41,MethyTransf_Reg,Methyltransf_12,Methyltransf_25,Methyltransf_31 HSJS3_k127_8654431_94 903818.KI912268_gene1766 0.0002943 51.0 COG0515@1|root,COG0515@2|Bacteria 903818.KI912268_gene1766|- KLT protein kinase activity - - - - - - - - - - - - - HSJS3_k127_8654431_24 1122164.JHWF01000019_gene477 2.777e-129 426.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1JC78@118969|Legionellales 118969|Legionellales H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 HSJS3_k127_8654431_41 743719.PaelaDRAFT_2487 1.233e-74 256.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26Q92@186822|Paenibacillaceae 91061|Bacilli G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim HSJS3_k127_8654431_82 926690.KE386573_gene362 8.499e-17 87.0 COG1310@1|root,arCOG01138@2157|Archaea,2XXA9@28890|Euryarchaeota,23VWD@183963|Halobacteria 183963|Halobacteria S metal-dependent protease of the PAD1 JAB1 superfamily jamm1 - 3.4.19.15 ko:K20110 - - - - ko00000,ko01000,ko01002 - - - Prok-JAB HSJS3_k127_8654431_25 1046724.KB889900_gene3205 9.1e-129 427.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,46AKM@72275|Alteromonadaceae 1236|Gammaproteobacteria H ThiF family moeB - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Prok-JAB,Rhodanese,ThiF,ThiS HSJS3_k127_8654431_27 1502850.FG91_01113 1.071e-120 406.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2K0J0@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT HSJS3_k127_8654431_33 379066.GAU_0192 2.936e-100 338.0 COG0075@1|root,COG0075@2|Bacteria,1ZTF3@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 HSJS3_k127_8654431_22 469371.Tbis_0134 9.095e-140 459.0 COG1115@1|root,COG1115@2|Bacteria,2GIU2@201174|Actinobacteria,4DZWP@85010|Pseudonocardiales 201174|Actinobacteria E TIGRFAM amino acid carrier protein alaP - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp HSJS3_k127_8654431_74 378806.STAUR_4856 1.227e-21 109.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2YU9X@29|Myxococcales 28221|Deltaproteobacteria JKL Belongs to the DEAD box helicase family deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C HSJS3_k127_8654431_40 880073.Calab_1658 6.569e-75 266.0 COG1226@1|root,COG1226@2|Bacteria,2NP71@2323|unclassified Bacteria 2|Bacteria U Ion channel kch - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N HSJS3_k127_8654431_91 861299.J421_2676 4.868e-05 55.0 2FDPQ@1|root,345QV@2|Bacteria,1ZU3Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8654431_7 574087.Acear_1954 5.805e-225 728.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,3WB5V@53433|Halanaerobiales 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC copA - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase HSJS3_k127_8654431_64 861299.J421_0446 2.178e-32 136.0 2F3M0@1|root,33WE8@2|Bacteria,1ZTTF@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8654431_30 344747.PM8797T_10544 1.002e-112 383.0 COG3635@1|root,COG3635@2|Bacteria,2IY5S@203682|Planctomycetes 203682|Planctomycetes G phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase HSJS3_k127_8654431_56 649638.Trad_0419 2.921e-42 163.0 COG1131@1|root,COG1131@2|Bacteria,1WI8V@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V ABC-type multidrug transport system ATPase component - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran HSJS3_k127_8654431_52 1144275.COCOR_03001 2.113e-50 187.0 COG2386@1|root,COG2386@2|Bacteria,1QF23@1224|Proteobacteria,42RAM@68525|delta/epsilon subdivisions,2WMS1@28221|Deltaproteobacteria,2YVDV@29|Myxococcales 28221|Deltaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB HSJS3_k127_8654431_45 196162.Noca_1955 1.707e-65 230.0 COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria 201174|Actinobacteria O cytochrome C assembly protein - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm HSJS3_k127_8654431_66 751945.Theos_1608 3.856e-31 127.0 COG2332@1|root,COG2332@2|Bacteria,1WJVR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE HSJS3_k127_8654431_9 671143.DAMO_1588 4.076e-210 673.0 COG1138@1|root,COG1138@2|Bacteria,2NNYV@2323|unclassified Bacteria 2|Bacteria O Cytochrome C assembly protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198,ko:K04016 - - R05712 RC00176 ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm HSJS3_k127_8654431_60 1089546.AQUI01000002_gene3229 6.029e-39 153.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin HSJS3_k127_8654431_75 1382306.JNIM01000001_gene133 2.579e-21 102.0 COG3088@1|root,COG3088@2|Bacteria,2G72W@200795|Chloroflexi 200795|Chloroflexi O subunit of a heme lyase ccmH - - ko:K02200 - - - - ko00000 - - - CcmH HSJS3_k127_8654431_31 861299.J421_2529 3.544e-112 369.0 COG0568@1|root,COG0568@2|Bacteria,1ZSNB@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 HSJS3_k127_8654431_77 292459.STH2564 3.867e-21 100.0 COG4243@1|root,COG4243@2|Bacteria 2|Bacteria S quinone binding - - - - - - - - - - - - Thioredoxin_4,VKOR HSJS3_k127_8654431_67 1128421.JAGA01000002_gene1958 2.623e-29 126.0 COG1651@1|root,COG1651@2|Bacteria 2|Bacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbA - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Thioredoxin_4 HSJS3_k127_8654431_57 1173028.ANKO01000116_gene5724 8.322e-42 173.0 COG0546@1|root,COG0546@2|Bacteria,1G6AW@1117|Cyanobacteria,1HCZI@1150|Oscillatoriales 1117|Cyanobacteria S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 HSJS3_k127_8654431_37 861299.J421_2397 9.932e-84 290.0 COG1171@1|root,COG1171@2|Bacteria,1ZTBP@142182|Gemmatimonadetes 2|Bacteria E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP HSJS3_k127_8654431_3 945713.IALB_0006 9.852e-305 956.0 COG0188@1|root,COG0188@2|Bacteria 2|Bacteria L DNA topoisomerase II activity gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV HSJS3_k127_8654431_42 448385.sce5794 2.948e-73 261.0 COG1086@1|root,COG1215@1|root,COG1086@2|Bacteria,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QGX@68525|delta/epsilon subdivisions,2WJPU@28221|Deltaproteobacteria,2YV0M@29|Myxococcales 28221|Deltaproteobacteria M Glycosyl transferase - - - - - - - - - - - - Glycos_transf_2 HSJS3_k127_8654431_1 861299.J421_3780 0.0 1031.0 COG0178@1|root,COG0178@2|Bacteria,1ZT1W@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran HSJS3_k127_8654431_11 861299.J421_3778 5.832e-186 599.0 COG1132@1|root,COG1132@2|Bacteria,1ZSZC@142182|Gemmatimonadetes 142182|Gemmatimonadetes V ABC transporter transmembrane region - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran HSJS3_k127_8654431_88 1569209.BBPH01000159_gene1102 4.626e-08 58.0 2ADW3@1|root,313N3@2|Bacteria,1PSPT@1224|Proteobacteria,2V4T8@28211|Alphaproteobacteria,2PXTJ@265|Paracoccus 28211|Alphaproteobacteria S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N HSJS3_k127_8654431_44 1379270.AUXF01000004_gene3140 3.449e-69 247.0 COG4324@1|root,COG4324@2|Bacteria,1ZT8G@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative aminopeptidase - - - - - - - - - - - - Aminopep HSJS3_k127_8654431_90 1396418.BATQ01000020_gene5031 2.448e-05 56.0 COG0589@1|root,COG0589@2|Bacteria 2|Bacteria T AMP binding - - - - - - - - - - - - SpoIIAA-like,Usp HSJS3_k127_8654431_72 379066.GAU_0167 2.854e-22 110.0 COG2924@1|root,COG2924@2|Bacteria,1ZTWZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic HSJS3_k127_8654431_2 861299.J421_2423 0.0 1018.0 COG0495@1|root,COG0495@2|Bacteria,1ZSXC@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Leucyl-tRNA synthetase, Domain 2 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 HSJS3_k127_8654431_85 379066.GAU_2585 1.59e-10 71.0 2C9AX@1|root,33WUH@2|Bacteria,1ZTQK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8654431_28 518766.Rmar_1743 2.624e-116 389.0 COG1082@1|root,COG1082@2|Bacteria,4NG1K@976|Bacteroidetes 976|Bacteroidetes G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 HSJS3_k127_8654431_48 28072.Nos7524_1498 7.116e-54 203.0 COG0053@1|root,COG0053@2|Bacteria,1G0RT@1117|Cyanobacteria,1HJJE@1161|Nostocales 1117|Cyanobacteria U Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer HSJS3_k127_8654431_5 1382304.JNIL01000001_gene3305 2.339e-281 878.0 COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,4H9PN@91061|Bacilli 91061|Bacilli I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C HSJS3_k127_8654431_53 1121440.AUMA01000005_gene2519 1.036e-49 186.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MBDA@213115|Desulfovibrionales 28221|Deltaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly HSJS3_k127_8654431_71 1242864.D187_009505 4.478e-25 121.0 COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria,2YUR5@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome c7 and related cytochrome c - - - - - - - - - - - - Cytochrome_C7 HSJS3_k127_8654431_23 1379698.RBG1_1C00001G0780 5.985e-133 440.0 COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria 2|Bacteria C Cytochrome b(N-terminal)/b6/petB petB - - ko:K00410,ko:K00412,ko:K02635,ko:K02637 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 - - ko00000,ko00001,ko00002,ko00194,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B HSJS3_k127_8654431_54 1379698.RBG1_1C00001G0781 8.992e-46 176.0 COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria 2|Bacteria C Rieske [2Fe-2S] domain petA - 1.10.2.2,1.10.9.1 ko:K00411,ko:K02636,ko:K03886 ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152,M00162 R03817,R08409 RC01002 ko00000,ko00001,ko00002,ko00194,ko01000 - - iAF987.Gmet_1922 CytB6-F_Fe-S,Rieske,UCR_Fe-S_N HSJS3_k127_8654431_32 671143.DAMO_0822 1.43e-103 353.0 COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB HSJS3_k127_8654431_62 565033.GACE_0099 4.012e-36 156.0 arCOG06549@1|root,arCOG06549@2157|Archaea,2Y31C@28890|Euryarchaeota,246R3@183980|Archaeoglobi 183980|Archaeoglobi C NapC/NirT cytochrome c family, N-terminal region - - - - - - - - - - - - Cytochrom_NNT HSJS3_k127_8654431_69 1191523.MROS_2048 9.707e-26 122.0 COG0737@1|root,COG3303@1|root,COG0737@2|Bacteria,COG3303@2|Bacteria 2|Bacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - 1.7.2.2 ko:K03385 ko00910,ko01120,ko05132,map00910,map01120,map05132 M00530 R05712 RC00176 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C,Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1,SBP_bac_8,SLH HSJS3_k127_8654431_43 1131269.AQVV01000013_gene1768 1.119e-70 254.0 COG0602@1|root,COG0602@2|Bacteria 2|Bacteria H queuosine metabolic process queE - 1.97.1.4,4.3.99.3 ko:K04068,ko:K10026 ko00790,ko01100,map00790,map01100 - R04710,R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - iAF987.Gmet_1658 Fer4_14,Radical_SAM HSJS3_k127_8654431_78 479434.Sthe_2099 5.491e-21 104.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding hcf136 - - - - - - - - - - - BNR HSJS3_k127_8654431_38 1227739.Hsw_2741 9.016e-82 282.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,47KF6@768503|Cytophagia 976|Bacteroidetes V TIGRFAM Gliding motility-associated ABC transporter ATP-binding subunit GldA gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran HSJS3_k127_8654431_47 1122621.ATZA01000014_gene3205 3.811e-60 233.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,4NF62@976|Bacteroidetes,1IR8V@117747|Sphingobacteriia 976|Bacteroidetes N transport system involved in gliding motility, auxiliary component gldG - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux HSJS3_k127_8654431_14 525904.Tter_0422 9.703e-171 548.0 COG0114@1|root,COG0114@2|Bacteria,2NS3X@2323|unclassified Bacteria 2|Bacteria C Fumarase C C-terminus fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 HSJS3_k127_8654431_68 713586.KB900536_gene1552 6.149e-26 115.0 COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria 1224|Proteobacteria S acr, cog1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 HSJS3_k127_8654431_65 861299.J421_2828 2.393e-31 129.0 COG0735@1|root,COG0735@2|Bacteria,1ZTN4@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Ferric uptake regulator family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR HSJS3_k127_8654431_51 1379270.AUXF01000002_gene1195 4.903e-51 188.0 COG0461@1|root,COG0461@2|Bacteria,1ZTMR@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran HSJS3_k127_8654431_35 1382306.JNIM01000001_gene4028 1.503e-86 304.0 COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi 200795|Chloroflexi C Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh HSJS3_k127_8654431_55 671143.DAMO_0398 2.863e-45 170.0 COG0316@1|root,COG0694@1|root,COG0316@2|Bacteria,COG0694@2|Bacteria 2|Bacteria O iron-sulfur cluster assembly iscA - - ko:K07400,ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn,Nfu_N,NifU HSJS3_k127_8654431_6 518766.Rmar_0629 1.469e-226 740.0 COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,4NERT@976|Bacteroidetes,1FJ3R@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes MU WD40-like Beta Propeller Repeat - - - - - - - - - - - - BSP,Bac_surface_Ag,PD40 HSJS3_k127_8654431_58 1125863.JAFN01000001_gene1511 1.786e-41 162.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR HSJS3_k127_8654431_80 1381123.AYOD01000021_gene1926 3.659e-19 102.0 COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,1MXGC@1224|Proteobacteria,2TVGX@28211|Alphaproteobacteria,43JA9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Copper resistance protein D ycnJ - - ko:K07245,ko:K14166 - - - - ko00000,ko02000 9.B.62.1 - - CopC,CopD HSJS3_k127_8654431_93 1408418.JNJH01000020_gene967 7.574e-05 48.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2JV8U@204441|Rhodospirillales 204441|Rhodospirillales L Recombinase zinc beta ribbon domain - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom HSJS3_k127_8654431_26 379066.GAU_0501 7.965e-122 403.0 COG1748@1|root,COG1748@2|Bacteria,1ZSMC@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Saccharopine dehydrogenase C-terminal domain - - 1.4.1.18 ko:K19064 ko00960,ko01100,ko01110,map00960,map01100,map01110 - R00446,R02317 RC00062,RC00694 ko00000,ko00001,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP HSJS3_k127_8654431_16 1232410.KI421426_gene1373 1.753e-162 542.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,43U78@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP HSJS3_k127_8654431_12 309807.SRU_0888 3.817e-181 595.0 COG0272@1|root,COG0272@2|Bacteria,4NE2X@976|Bacteroidetes,1FJ26@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 HSJS3_k127_8654431_84 1087481.AGFX01000018_gene1901 9.702e-12 70.0 COG2259@1|root,COG2259@2|Bacteria,1VCS2@1239|Firmicutes,4HKRK@91061|Bacilli,26YZ6@186822|Paenibacillaceae 91061|Bacilli S membrane catD - - - - - - - - - - - DoxX HSJS3_k127_8654431_34 1122939.ATUD01000011_gene2213 1.84e-88 299.0 COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4CPSB@84995|Rubrobacteria 84995|Rubrobacteria L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG HSJS3_k127_8654431_59 1457250.BBMO01000001_gene1903 2.552e-39 151.0 COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,23V54@183963|Halobacteria 183963|Halobacteria K COG1522 Transcriptional regulators asnC1 - - - - - - - - - - - AsnC_trans_reg,HTH_24 HSJS3_k127_8654431_17 479435.Kfla_2118 4.303e-161 525.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,2GMMC@201174|Actinobacteria,4DPP6@85009|Propionibacteriales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.17.1.9,1.6.5.3 ko:K00122,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB HSJS3_k127_8654431_89 472759.Nhal_1980 6.713e-07 56.0 2DD9Q@1|root,2ZH70@2|Bacteria,1P8P5@1224|Proteobacteria,1SWFT@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8654431_0 1048339.KB913029_gene4928 0.0 1161.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4ERF8@85013|Frankiales 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123,ko:K00372 ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200 M00531 R00519,R00798,R01106 RC02796,RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 HSJS3_k127_8654431_19 1254432.SCE1572_18340 9.243e-158 508.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2WKPM@28221|Deltaproteobacteria,2YTUX@29|Myxococcales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 HSJS3_k127_8654431_10 1307759.JOMJ01000004_gene2764 6.859e-210 676.0 COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MEGJ@213115|Desulfovibrionales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,SLC12 HSJS3_k127_8654431_50 1172179.AUKV01000006_gene6065 2.051e-51 201.0 COG2303@1|root,COG2303@2|Bacteria,2GNHC@201174|Actinobacteria 201174|Actinobacteria E glucose-methanol-choline oxidoreductase - - 1.1.1.400 ko:K20927,ko:K21166 ko01059,ko01130,map01059,map01130 M00824 - - ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N HSJS3_k127_8654431_73 743836.AYNA01000121_gene2563 9.711e-22 100.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,3704V@31993|Methylocystaceae 28211|Alphaproteobacteria O Hsp20/alpha crystallin family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 HSJS3_k127_8654431_92 103690.17129767 6.66e-05 55.0 COG3391@1|root,COG3391@2|Bacteria,1G499@1117|Cyanobacteria,1HKTY@1161|Nostocales 1117|Cyanobacteria S NHL repeat - - - - - - - - - - - - DUF5128,NHL,VPEP HSJS3_k127_8654431_83 929703.KE386491_gene114 4.485e-15 87.0 2DBDT@1|root,2Z8NY@2|Bacteria,4NHYG@976|Bacteroidetes,47RTW@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_8654431_70 379066.GAU_0906 1.574e-25 111.0 COG2839@1|root,COG2839@2|Bacteria,1ZUVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF456) - - - ko:K09793 - - - - ko00000 - - - DUF456 HSJS3_k127_8654431_86 1336243.JAEA01000010_gene3491 6.318e-09 62.0 COG4319@1|root,COG4319@2|Bacteria,1N5R1@1224|Proteobacteria,2TVTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 HSJS3_k127_8654431_4 1173027.Mic7113_0014 7.916e-296 925.0 COG0531@1|root,COG0531@2|Bacteria,1G248@1117|Cyanobacteria,1H8SD@1150|Oscillatoriales 1117|Cyanobacteria E amino acid - - - - - - - - - - - - AA_permease,SLC12 HSJS3_k127_8654431_39 118166.JH976537_gene2038 4.333e-78 266.0 COG2818@1|root,COG2818@2|Bacteria,1G5Y1@1117|Cyanobacteria,1HF1X@1150|Oscillatoriales 1117|Cyanobacteria L Methyladenine glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco HSJS3_k127_8654431_20 102232.GLO73106DRAFT_00015860 2.813e-150 490.0 COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept HSJS3_k127_8654431_29 1121904.ARBP01000009_gene4348 3.931e-115 390.0 COG1228@1|root,COG1228@2|Bacteria,4NEV0@976|Bacteroidetes,47MH5@768503|Cytophagia 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 HSJS3_k127_8654431_49 1191523.MROS_0403 5.036e-53 192.0 COG3040@1|root,COG3040@2|Bacteria 2|Bacteria M lipid binding - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 HSJS3_k127_8654431_63 314345.SPV1_11671 3.277e-35 139.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria 1224|Proteobacteria O Peptidylprolyl isomerase ppiC GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 HSJS3_k127_8654431_61 251221.35210563 9.651e-39 158.0 COG0580@1|root,COG0580@2|Bacteria,1G0AW@1117|Cyanobacteria 1117|Cyanobacteria U Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP HSJS3_k127_8654431_81 745014.OMB55_00014950 6.66e-19 87.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,Cupin_3 HSJS3_k127_8654431_46 1183438.GKIL_0852 5.04e-62 242.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - CsgG,TPR_16 HSJS3_k127_8721437_3 861299.J421_2988 3.75e-120 409.0 COG0457@1|root,COG0659@1|root,COG0457@2|Bacteria,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity - - - - - - - - - - - - - HSJS3_k127_8721437_4 1454004.AW11_02812 4.814e-94 327.0 COG2010@1|root,COG2010@2|Bacteria,1RDNN@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrome_C554 HSJS3_k127_8721437_0 861299.J421_3571 0.0 1479.0 COG0458@1|root,COG0458@2|Bacteria,1ZSPK@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS HSJS3_k127_8721437_7 468059.AUHA01000004_gene2375 3.719e-38 157.0 2BXBG@1|root,33WQF@2|Bacteria,4P3CB@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - HSJS3_k127_8721437_8 1385935.N836_10115 2.363e-36 150.0 COG0500@1|root,COG2226@2|Bacteria,1G3CH@1117|Cyanobacteria,1HAB6@1150|Oscillatoriales 1117|Cyanobacteria H Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11 HSJS3_k127_8721437_5 251221.35210613 2.512e-78 284.0 COG0596@1|root,COG4188@1|root,COG0596@2|Bacteria,COG4188@2|Bacteria,1G7IV@1117|Cyanobacteria 1117|Cyanobacteria S TAP-like protein - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 HSJS3_k127_8721437_2 1379270.AUXF01000007_gene964 1.528e-185 597.0 COG0308@1|root,COG0308@2|Bacteria,1ZU50@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 HSJS3_k127_8721437_1 518766.Rmar_2521 1.308e-186 601.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1FKC5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 HSJS3_k127_8721437_6 670487.Ocepr_1720 1.71e-42 160.0 COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM aromatic amino acid beta-eliminating lyase threonine aldolase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase HSJS3_k127_8732411_8 635013.TherJR_0014 2.073e-139 455.0 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,260VV@186807|Peptococcaceae 186801|Clostridia J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b HSJS3_k127_8732411_25 861299.J421_3171 1.731e-87 301.0 COG0836@1|root,COG0836@2|Bacteria,1ZT5Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Nucleotidyl transferase - - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase HSJS3_k127_8732411_37 1379270.AUXF01000005_gene804 1.72e-64 239.0 COG1208@1|root,COG1208@2|Bacteria,1ZSVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes JM Sugar nucleotidyl transferase - - - - - - - - - - - - NTP_transf_4 HSJS3_k127_8732411_38 861299.J421_3169 2.973e-58 216.0 COG1235@1|root,COG1235@2|Bacteria,1ZTN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B_2 HSJS3_k127_8732411_32 1125863.JAFN01000001_gene963 4.913e-73 259.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria 28221|Deltaproteobacteria M SMART PDZ DHR GLGF domain protein rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 HSJS3_k127_8732411_19 861299.J421_3406 3.334e-113 382.0 COG0743@1|root,COG0743@2|Bacteria,1ZTFR@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom HSJS3_k127_8732411_50 861299.J421_3407 2.498e-44 171.0 COG4589@1|root,COG4589@2|Bacteria,1ZTGH@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 HSJS3_k127_8732411_27 861299.J421_3408 6.031e-86 291.0 COG0020@1|root,COG0020@2|Bacteria,1ZSNJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids - - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf HSJS3_k127_8732411_11 518766.Rmar_0596 3.552e-135 445.0 COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria 2|Bacteria P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 THUMP,ThiI HSJS3_k127_8732411_42 1123368.AUIS01000018_gene733 2.272e-51 198.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - ko:K17247 - - - - ko00000 - - - Ferric_reduct HSJS3_k127_8732411_14 1123401.JHYQ01000009_gene2293 1.334e-127 415.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,4609Z@72273|Thiotrichales 72273|Thiotrichales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb HSJS3_k127_8732411_70 566466.NOR53_420 5.65e-09 63.0 2EM9G@1|root,33EYK@2|Bacteria,1P8EM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8732411_52 1515746.HR45_00595 1.086e-40 157.0 28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S2BA@1236|Gammaproteobacteria,2QBBD@267890|Shewanellaceae 1236|Gammaproteobacteria - - VP2004 - - - - - - - - - - - - HSJS3_k127_8732411_71 1229780.BN381_130143 4.088e-08 55.0 2DREZ@1|root,33BFB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_8732411_74 861299.J421_3012 8.334e-07 55.0 COG2919@1|root,COG2919@2|Bacteria,1ZU6R@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Septum formation initiator - - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC HSJS3_k127_8732411_4 935567.JAES01000034_gene1719 2.358e-166 533.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N HSJS3_k127_8732411_65 1123277.KB893181_gene2211 2.036e-17 93.0 COG0330@1|root,COG0330@2|Bacteria,4NFNB@976|Bacteroidetes,47MT6@768503|Cytophagia 976|Bacteroidetes O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 HSJS3_k127_8732411_39 861299.J421_3009 4.651e-55 206.0 COG0611@1|root,COG0611@2|Bacteria,1ZTIU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C HSJS3_k127_8732411_75 59374.Fisuc_1754 9.358e-05 55.0 COG3292@1|root,COG3637@1|root,COG3292@2|Bacteria,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety msp3 - - ko:K12976,ko:K19693,ko:K21572 - - - - ko00000,ko01000,ko01005,ko02000,ko03000 8.A.46.1,8.A.46.3 - - DUF5074,OMP_b-brl,Surface_Ag_2,fn3 HSJS3_k127_8732411_36 760568.Desku_2838 9.123e-67 247.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,260CR@186807|Peptococcaceae 186801|Clostridia H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N HSJS3_k127_8732411_61 861299.J421_3007 3.801e-28 113.0 2EQ8R@1|root,33HV0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_8732411_60 1379270.AUXF01000005_gene601 1.327e-30 126.0 2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8732411_59 880073.Calab_1085 1.067e-30 130.0 COG1739@1|root,COG1739@2|Bacteria,2NPZP@2323|unclassified Bacteria 2|Bacteria S Uncharacterized protein family UPF0029 yigZ - 2.1.1.45,3.4.13.9 ko:K00560,ko:K01271 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000,ko01002 - - - DUF1949,UPF0029 HSJS3_k127_8732411_3 1123226.KB899283_gene3175 2.524e-167 542.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,4HA5K@91061|Bacilli,26S4Z@186822|Paenibacillaceae 91061|Bacilli E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT HSJS3_k127_8732411_9 861299.J421_3004 3.973e-138 449.0 COG0334@1|root,COG0334@2|Bacteria,1ZTBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N HSJS3_k127_8732411_10 861299.J421_3003 7.33e-137 446.0 COG1960@1|root,COG1960@2|Bacteria,1ZSRC@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N HSJS3_k127_8732411_20 1379270.AUXF01000005_gene596 2.735e-108 357.0 COG1250@1|root,COG1250@2|Bacteria,1ZSRN@142182|Gemmatimonadetes 142182|Gemmatimonadetes I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N HSJS3_k127_8732411_62 1330700.JQNC01000003_gene750 3.004e-27 120.0 COG1268@1|root,COG1268@2|Bacteria,1WJ9M@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PFAM BioY protein bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY HSJS3_k127_8732411_5 861299.J421_3000 4.662e-158 508.0 COG0183@1|root,COG0183@2|Bacteria,1ZTGX@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N HSJS3_k127_8732411_66 761193.Runsl_2852 8.065e-17 90.0 2CM2H@1|root,32SDI@2|Bacteria,4NSAF@976|Bacteroidetes,47R71@768503|Cytophagia 976|Bacteroidetes S Putative lumazine-binding - - - - - - - - - - - - Lumazine_bd_2 HSJS3_k127_8732411_22 1379270.AUXF01000006_gene81 2.928e-99 332.0 COG0491@1|root,COG0491@2|Bacteria,1ZT7V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B HSJS3_k127_8732411_44 1379270.AUXF01000006_gene80 2.588e-50 190.0 COG0847@1|root,COG0847@2|Bacteria,1ZTNH@142182|Gemmatimonadetes 142182|Gemmatimonadetes L EXOIII - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T HSJS3_k127_8732411_31 869213.JCM21142_96 3.076e-73 264.0 COG2235@1|root,COG2235@2|Bacteria,4NHKZ@976|Bacteroidetes,47JM7@768503|Cytophagia 976|Bacteroidetes E Arginine deiminase - - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf HSJS3_k127_8732411_47 1379698.RBG1_1C00001G0285 4.415e-47 177.0 COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria 2|Bacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N HSJS3_k127_8732411_46 485915.Dret_1901 7.458e-49 184.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2MB4Q@213115|Desulfovibrionales 28221|Deltaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD HSJS3_k127_8732411_34 861299.J421_3453 2.24e-67 248.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1ZSPW@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE HSJS3_k127_8732411_64 644282.Deba_1225 1.103e-20 102.0 COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria,1PGJ3@1224|Proteobacteria,4315J@68525|delta/epsilon subdivisions,2WWDE@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2,Response_reg HSJS3_k127_8732411_57 861299.J421_3455 8.971e-35 149.0 COG1366@1|root,COG1366@2|Bacteria,1ZTXM@142182|Gemmatimonadetes 142182|Gemmatimonadetes T STAS domain - - - ko:K04749 - - - - ko00000,ko03021 - - - STAS HSJS3_k127_8732411_28 1379270.AUXF01000006_gene74 1.851e-80 279.0 COG0280@1|root,COG0280@2|Bacteria,1ZT01@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Phosphate acetyl/butaryl transferase - - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB HSJS3_k127_8732411_40 1260251.SPISAL_01105 3.089e-54 196.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales 135613|Chromatiales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like HSJS3_k127_8732411_53 861299.J421_3458 6.272e-37 148.0 COG0742@1|root,COG0742@2|Bacteria,1ZTVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 HSJS3_k127_8732411_18 1345697.M493_13375 5.541e-119 408.0 COG0608@1|root,COG4199@1|root,COG0608@2|Bacteria,COG4199@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,1WE5V@129337|Geobacillus 91061|Bacilli L Single-strand DNA-specific exonuclease, C terminal domain recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1,ssDNA-exonuc_C HSJS3_k127_8732411_69 643867.Ftrac_3578 2.297e-11 73.0 COG1579@1|root,COG1579@2|Bacteria,4NE36@976|Bacteroidetes,47JBK@768503|Cytophagia 976|Bacteroidetes S Zn-ribbon protein, possibly nucleic acid-binding - - - ko:K07164 - - - - ko00000 - - - zf-RING_7 HSJS3_k127_8732411_15 379066.GAU_1891 4.831e-127 428.0 COG0358@1|root,COG0358@2|Bacteria,1ZSTR@142182|Gemmatimonadetes 142182|Gemmatimonadetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_N,zf-CHC2 HSJS3_k127_8732411_7 1379270.AUXF01000006_gene68 4.154e-147 497.0 COG1193@1|root,COG1193@2|Bacteria,1ZSWM@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr HSJS3_k127_8732411_56 870187.Thini_3512 2.225e-36 144.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,4610M@72273|Thiotrichales 72273|Thiotrichales FG Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT HSJS3_k127_8732411_55 379066.GAU_1896 2.066e-36 149.0 COG1385@1|root,COG1385@2|Bacteria,1ZTJ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA HSJS3_k127_8732411_76 293826.Amet_3701 0.0004737 49.0 2C0MY@1|root,2ZC2Z@2|Bacteria,1V9XB@1239|Firmicutes,24PCF@186801|Clostridia,36J6H@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - HSJS3_k127_8732411_0 1123368.AUIS01000001_gene1896 3.744e-285 892.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1SJQ1@1236|Gammaproteobacteria,2NDRU@225057|Acidithiobacillales 225057|Acidithiobacillales G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N HSJS3_k127_8732411_45 485917.Phep_2450 7.16e-50 183.0 COG0698@1|root,COG0698@2|Bacteria,4NP5D@976|Bacteroidetes,1ISW3@117747|Sphingobacteriia 976|Bacteroidetes G Ribose 5-phosphate isomerase - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB HSJS3_k127_8732411_1 247490.KSU1_C1633 8.509e-266 848.0 COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2IY2M@203682|Planctomycetes 203682|Planctomycetes H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA HSJS3_k127_8732411_51 926549.KI421517_gene3972 3.624e-43 164.0 COG2318@1|root,COG2318@2|Bacteria,4NQBY@976|Bacteroidetes,47PR7@768503|Cytophagia 976|Bacteroidetes S DinB superfamily - - - - - - - - - - - - DinB_2 HSJS3_k127_8732411_13 861299.J421_3468 1.22e-127 419.0 COG0484@1|root,COG0484@2|Bacteria,1ZSVD@142182|Gemmatimonadetes 142182|Gemmatimonadetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG HSJS3_k127_8732411_21 379066.GAU_1899 1.88e-99 339.0 COG1420@1|root,COG1420@2|Bacteria,1ZTER@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA HSJS3_k127_8732411_23 861299.J421_3470 3.666e-92 327.0 COG0635@1|root,COG0635@2|Bacteria,1ZSSU@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Radical_SAM HSJS3_k127_8732411_41 573370.DMR_34070 8.289e-53 207.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WUIF@28221|Deltaproteobacteria,2MG5E@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA recombination-mediator protein A - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A HSJS3_k127_8732411_16 861299.J421_3472 3.85e-124 410.0 COG0536@1|root,COG0536@2|Bacteria,1ZSVS@142182|Gemmatimonadetes 142182|Gemmatimonadetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 HSJS3_k127_8732411_54 861299.J421_3473 1.922e-36 148.0 COG0599@1|root,COG0599@2|Bacteria,1ZTPF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD HSJS3_k127_8732411_35 379066.GAU_1904 5.4e-67 240.0 COG4448@1|root,COG4448@2|Bacteria,1ZTG2@142182|Gemmatimonadetes 142182|Gemmatimonadetes E L-asparaginase II - - - - - - - - - - - - Asparaginase_II HSJS3_k127_8732411_73 309807.SRU_1114 7.07e-07 55.0 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - FMN_bind,PG_binding_1 HSJS3_k127_8732411_67 414684.RC1_2393 1.181e-16 85.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,2JTW3@204441|Rhodospirillales 204441|Rhodospirillales L bacterial (prokaryotic) histone like domain - - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding HSJS3_k127_8732411_24 861299.J421_0464 6.138e-88 313.0 COG0793@1|root,COG0793@2|Bacteria,1ZT92@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 HSJS3_k127_8732411_26 861299.J421_2940 2.299e-87 313.0 COG0793@1|root,COG0793@2|Bacteria,1ZSUF@142182|Gemmatimonadetes 142182|Gemmatimonadetes M tail specific protease - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 HSJS3_k127_8732411_49 1540221.JQNI01000002_gene2710 2.18e-44 170.0 COG0125@1|root,COG0125@2|Bacteria,1WK3U@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin HSJS3_k127_8732411_2 861299.J421_3601 1.46e-211 664.0 COG1260@1|root,COG1260@2|Bacteria,1ZT2X@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth,NAD_binding_5 HSJS3_k127_8732411_58 266117.Rxyl_2978 3.961e-32 139.0 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CQHA@84995|Rubrobacteria 84995|Rubrobacteria I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf HSJS3_k127_8732411_68 1379270.AUXF01000005_gene498 2.848e-13 78.0 COG3679@1|root,COG3679@2|Bacteria,1ZTRW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Control of competence regulator ComK, YlbF/YmcA - - - - - - - - - - - - Com_YlbF HSJS3_k127_8732411_48 382464.ABSI01000022_gene490 1.642e-45 177.0 COG2890@1|root,COG2890@2|Bacteria,46SZE@74201|Verrucomicrobia,2IU5P@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS HSJS3_k127_8732411_12 861299.J421_2936 1.436e-128 420.0 COG0216@1|root,COG0216@2|Bacteria,1ZSNT@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 HSJS3_k127_8732411_63 744872.Spica_1603 2.148e-24 106.0 COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes 203691|Spirochaetes J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 HSJS3_k127_8732411_33 930169.B5T_01958 4.673e-69 247.0 COG0300@1|root,COG0300@2|Bacteria,1R7MT@1224|Proteobacteria,1S0XC@1236|Gammaproteobacteria,1XR3K@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short HSJS3_k127_8732411_17 518766.Rmar_1990 6.844e-120 395.0 COG4257@1|root,COG4257@2|Bacteria 2|Bacteria V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - DUF5011 HSJS3_k127_8732411_6 1278073.MYSTI_01766 9.692e-148 499.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria 1224|Proteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - - - - - - - - - - FtsX,MacB_PCD HSJS3_k127_8732411_43 404589.Anae109_0937 5.806e-51 190.0 COG0457@1|root,COG0457@2|Bacteria,1N4HS@1224|Proteobacteria,43753@68525|delta/epsilon subdivisions,2X219@28221|Deltaproteobacteria,2Z10F@29|Myxococcales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_11 HSJS3_k127_8732411_29 861299.J421_5988 4.899e-78 277.0 COG1273@1|root,COG1273@2|Bacteria 2|Bacteria M With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku HSJS3_k127_8732411_30 861299.J421_5987 2.221e-77 269.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria 2|Bacteria L DNA ligase (ATP) activity - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N HSJS3_k127_8807485_1 296591.Bpro_2639 2.081e-93 317.0 COG1917@1|root,COG1917@2|Bacteria,1RH0Y@1224|Proteobacteria,2VWWA@28216|Betaproteobacteria 28216|Betaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - HSJS3_k127_8807485_2 309801.trd_A0009 3.814e-46 173.0 COG1335@1|root,COG1335@2|Bacteria,2G6JY@200795|Chloroflexi 200795|Chloroflexi Q Isochorismatase family - - - - - - - - - - - - Isochorismatase HSJS3_k127_8807485_0 907348.TresaDRAFT_1176 1.077e-109 369.0 COG0667@1|root,COG0667@2|Bacteria,2J6C3@203691|Spirochaetes 203691|Spirochaetes C PFAM Aldo keto reductase family - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red HSJS3_k127_8807485_3 861299.J421_5846 3.409e-22 98.0 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C HSJS3_k127_8914414_27 1198114.AciX9_2740 6.589e-06 59.0 COG4319@1|root,COG4319@2|Bacteria,3Y4YW@57723|Acidobacteria,2JJHI@204432|Acidobacteriia 204432|Acidobacteriia S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 HSJS3_k127_8914414_10 387093.SUN_1308 1.073e-75 265.0 COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,42SIA@68525|delta/epsilon subdivisions,2YREF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos HSJS3_k127_8914414_14 706587.Desti_1800 2.752e-67 236.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,42SGK@68525|delta/epsilon subdivisions,2WPDI@28221|Deltaproteobacteria,2MS7N@213462|Syntrophobacterales 28221|Deltaproteobacteria S Dienelactone hydrolase family - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_4,Abhydrolase_5,DLH HSJS3_k127_8914414_1 517418.Ctha_2249 4.922e-143 467.0 COG3540@1|root,COG3540@2|Bacteria 2|Bacteria P PhoD-like phosphatase phoD - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD HSJS3_k127_8914414_2 215803.DB30_7007 1.564e-132 440.0 COG1181@1|root,COG2940@1|root,COG1181@2|Bacteria,COG2940@2|Bacteria,1Q3H4@1224|Proteobacteria,4399M@68525|delta/epsilon subdivisions,2X4H1@28221|Deltaproteobacteria,2YZ01@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C HSJS3_k127_8914414_24 163908.KB235896_gene750 1.465e-15 90.0 COG2931@1|root,COG3211@1|root,COG2931@2|Bacteria,COG3211@2|Bacteria,1GIZZ@1117|Cyanobacteria,1HJZZ@1161|Nostocales 1117|Cyanobacteria Q Bacterial protein of unknown function (DUF839) - - - - - - - - - - - - DUF839 HSJS3_k127_8914414_5 525897.Dbac_0042 5.476e-108 366.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2M87X@213115|Desulfovibrionales 28221|Deltaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 HSJS3_k127_8914414_3 1239962.C943_00789 6.907e-125 424.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,47MWY@768503|Cytophagia 976|Bacteroidetes EU Peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - FGE-sulfatase,PD40,Peptidase_S9 HSJS3_k127_8914414_7 1122176.KB903551_gene4256 5.23e-90 312.0 COG4409@1|root,COG4409@2|Bacteria,4NI5M@976|Bacteroidetes,1IU97@117747|Sphingobacteriia 976|Bacteroidetes G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - BNR_2 HSJS3_k127_8914414_26 1379270.AUXF01000002_gene1380 2.041e-10 70.0 2CDZB@1|root,2ZBFS@2|Bacteria,1ZTIQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8914414_0 1089553.Tph_c04700 3.571e-157 503.0 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,42GR1@68295|Thermoanaerobacterales 186801|Clostridia E PFAM Peptidase M29, aminopeptidase II - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 HSJS3_k127_8914414_4 865861.AZSU01000006_gene1375 6.38e-119 401.0 COG0031@1|root,COG0031@2|Bacteria,1UZEQ@1239|Firmicutes,24BCR@186801|Clostridia,36G6F@31979|Clostridiaceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP HSJS3_k127_8914414_8 1242864.D187_006584 3.444e-78 281.0 COG0204@1|root,COG0204@2|Bacteria,1R72B@1224|Proteobacteria 1224|Proteobacteria I COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - - - - - - - - - - Acyltransferase HSJS3_k127_8914414_9 743722.Sph21_5208 4.152e-77 268.0 COG4221@1|root,COG4221@2|Bacteria,4NE1R@976|Bacteroidetes,1INN2@117747|Sphingobacteriia 976|Bacteroidetes NU Belongs to the short-chain dehydrogenases reductases (SDR) family ydfG - - - - - - - - - - - adh_short HSJS3_k127_8914414_15 469383.Cwoe_5609 2.49e-61 228.0 COG0558@1|root,COG0558@2|Bacteria,2H9R3@201174|Actinobacteria 201174|Actinobacteria I CDP-alcohol phosphatidyltransferase - - - - - - - - - - - - CDP-OH_P_transf HSJS3_k127_8914414_6 1122179.KB890480_gene3166 8.652e-103 354.0 COG0457@1|root,COG0457@2|Bacteria,4NFMI@976|Bacteroidetes,1IV5V@117747|Sphingobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 HSJS3_k127_8914414_22 1239962.C943_03877 1.084e-27 126.0 COG0823@1|root,COG0823@2|Bacteria,4NEPF@976|Bacteroidetes,47NVJ@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - CarbopepD_reg_2,CarboxypepD_reg,PD40 HSJS3_k127_8914414_12 861299.J421_2152 1.848e-70 268.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria 2|Bacteria K phosphorelay signal transduction system - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,BTAD,TPR_12,Trans_reg_C HSJS3_k127_8914414_19 1249627.D779_3605 5.943e-36 143.0 COG0662@1|root,COG0662@2|Bacteria,1N00P@1224|Proteobacteria,1S759@1236|Gammaproteobacteria,1WYP8@135613|Chromatiales 135613|Chromatiales G PFAM Cupin - - - - - - - - - - - - Cupin_2 HSJS3_k127_8914414_25 1120953.AUBH01000001_gene853 1.491e-10 69.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CaMKII_AD,DUF4440,SnoaL_2,SnoaL_3 HSJS3_k127_8914414_13 1499967.BAYZ01000194_gene3127 2.668e-69 243.0 COG1994@1|root,COG1994@2|Bacteria 2|Bacteria S metallopeptidase activity ywhC - - - - - - - - - - - Peptidase_M50 HSJS3_k127_8914414_11 379066.GAU_0768 2.636e-73 252.0 COG1435@1|root,COG1435@2|Bacteria,1ZTB2@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Thymidine kinase tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK HSJS3_k127_8914414_20 224324.aq_035 8.676e-31 140.0 COG2199@1|root,COG3706@2|Bacteria,2G439@200783|Aquificae 200783|Aquificae T Diguanylate cyclase - - - - - - - - - - - - GGDEF,Lactamase_B HSJS3_k127_8914414_21 861299.J421_3954 2.645e-28 124.0 2C0MY@1|root,30KW5@2|Bacteria,1ZTVN@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_8914414_17 177437.HRM2_33720 2.841e-39 149.0 COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,42U37@68525|delta/epsilon subdivisions,2WQ9M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 HSJS3_k127_8914414_18 1168059.KB899087_gene4324 3.709e-36 140.0 2CWCM@1|root,32SZF@2|Bacteria,1N037@1224|Proteobacteria,2UCWU@28211|Alphaproteobacteria,3F1T6@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4260) - - - - - - - - - - - - DUF4260 HSJS3_k127_8914414_23 439375.Oant_3962 1.041e-26 117.0 29CEM@1|root,2ZZD2@2|Bacteria,1QG5T@1224|Proteobacteria,2V4FV@28211|Alphaproteobacteria,1J39A@118882|Brucellaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_8914414_16 379066.GAU_2496 2.061e-50 188.0 COG3437@1|root,COG3437@2|Bacteria,1ZUP1@142182|Gemmatimonadetes 142182|Gemmatimonadetes KT HD domain - - - - - - - - - - - - - HSJS3_k127_9142011_0 1057002.KB905370_gene3674 1.22e-204 647.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,4BB6Z@82115|Rhizobiaceae 28211|Alphaproteobacteria P cation efflux system protein (Heavy metal efflux pump) - - - - - - - - - - - - ACR_tran HSJS3_k127_9142011_3 1123073.KB899242_gene1060 5.768e-73 259.0 2DSGQ@1|root,33G29@2|Bacteria 2|Bacteria S Putative porin - - - - - - - - - - - - Porin_5 HSJS3_k127_9142011_5 1038859.AXAU01000003_gene6191 8.406e-40 157.0 2FGTF@1|root,348NS@2|Bacteria,1P2M9@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - HSJS3_k127_9142011_2 448385.sce0969 1.68e-80 280.0 COG1409@1|root,COG1409@2|Bacteria,1R0BM@1224|Proteobacteria,43CTY@68525|delta/epsilon subdivisions,2X81I@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - - HSJS3_k127_9142011_4 1123368.AUIS01000019_gene1213 5.19e-69 237.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S40Y@1236|Gammaproteobacteria,2NCY9@225057|Acidithiobacillales 225057|Acidithiobacillales C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 HSJS3_k127_9142011_1 518766.Rmar_0585 5.48e-200 651.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 HSJS3_k127_9142011_6 2002.JOEQ01000006_gene1335 1.275e-12 68.0 COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4EI63@85012|Streptosporangiales 201174|Actinobacteria S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA,AAA_5 HSJS3_k127_9148175_1 861299.J421_3231 1.628e-166 543.0 COG0322@1|root,COG0322@2|Bacteria,1ZSXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_5,UVR,UvrC_HhH_N HSJS3_k127_9148175_3 479434.Sthe_0784 8.553e-104 349.0 COG0498@1|root,COG0498@2|Bacteria,2G5RK@200795|Chloroflexi,27Y4R@189775|Thermomicrobia 189775|Thermomicrobia E Threonine synthase - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP HSJS3_k127_9148175_16 589873.EP13_03115 2.368e-07 63.0 COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,46696@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 HSJS3_k127_9148175_4 861299.J421_3234 2.935e-103 350.0 COG1625@1|root,COG1625@2|Bacteria,1ZSQ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 HSJS3_k127_9148175_2 1356854.N007_14560 8.15e-128 423.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,278SV@186823|Alicyclobacillaceae 91061|Bacilli S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 HSJS3_k127_9148175_12 1408423.JHYA01000001_gene1136 5.669e-45 169.0 COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,4H4AN@909932|Negativicutes 909932|Negativicutes I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf HSJS3_k127_9148175_6 404380.Gbem_0008 3.232e-92 314.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,43TUN@69541|Desulfuromonadales 28221|Deltaproteobacteria I NAD-dependent glycerol-3-phosphate dehydrogenase domain protein gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N HSJS3_k127_9148175_13 1379270.AUXF01000006_gene283 7.913e-36 140.0 COG0789@1|root,COG0789@2|Bacteria,1ZTSI@142182|Gemmatimonadetes 142182|Gemmatimonadetes K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 HSJS3_k127_9148175_8 379066.GAU_1605 2.703e-86 291.0 COG0496@1|root,COG0496@2|Bacteria,1ZT6W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE HSJS3_k127_9148175_10 861299.J421_3240 9.183e-64 232.0 COG2518@1|root,COG2518@2|Bacteria,1ZTED@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT HSJS3_k127_9148175_11 177437.HRM2_11110 2.667e-56 206.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,42TAU@68525|delta/epsilon subdivisions,2WPD6@28221|Deltaproteobacteria,2MNAW@213118|Desulfobacterales 28221|Deltaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc HSJS3_k127_9148175_7 1379270.AUXF01000006_gene276 1.753e-87 295.0 COG0463@1|root,COG0463@2|Bacteria,1ZT31@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Glycosyltransferase like family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 HSJS3_k127_9148175_9 1379698.RBG1_1C00001G1315 3.705e-78 274.0 COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria 2|Bacteria M Glycosyltransferase like family 2 arnC - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 HSJS3_k127_9148175_0 861299.J421_3250 2.09e-191 608.0 COG1508@1|root,COG1508@2|Bacteria,1ZT13@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Sigma-54 factor, Activator interacting domain (AID) - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD HSJS3_k127_9148175_17 67281.JNZZ01000001_gene2055 1.595e-05 57.0 COG3379@1|root,COG3379@2|Bacteria,2H3W9@201174|Actinobacteria 201174|Actinobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest HSJS3_k127_9148175_15 1047013.AQSP01000131_gene1844 1.716e-18 96.0 COG1238@1|root,COG1238@2|Bacteria 2|Bacteria I metal cluster binding yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - SNARE_assoc HSJS3_k127_9148175_5 861299.J421_3251 1.237e-94 321.0 COG1137@1|root,COG1137@2|Bacteria,1ZT4S@142182|Gemmatimonadetes 142182|Gemmatimonadetes S ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran HSJS3_k127_9148175_14 1379270.AUXF01000006_gene270 1.25e-29 132.0 2F01D@1|root,33T57@2|Bacteria,1ZTGK@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - HSJS3_k127_9363930_0 518766.Rmar_1691 1.374e-208 665.0 COG1452@1|root,COG1452@2|Bacteria,4NFWD@976|Bacteroidetes,1FIP2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Organic solvent tolerance protein OstA - - - - - - - - - - - - - HSJS3_k127_9363930_1 518766.Rmar_1690 8.226e-05 45.0 COG1940@1|root,COG1940@2|Bacteria,4NFZ1@976|Bacteroidetes,1FIR3@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK HSJS3_k127_9426597_32 1210884.HG799463_gene9875 9.748e-24 109.0 COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2IZZJ@203682|Planctomycetes 203682|Planctomycetes I Diacylglycerol kinase catalytic region - - - - - - - - - - - - DAGK_cat HSJS3_k127_9426597_23 32057.KB217478_gene2676 1.285e-45 173.0 COG0135@1|root,COG0135@2|Bacteria,1G8QG@1117|Cyanobacteria,1HQDY@1161|Nostocales 1117|Cyanobacteria E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI HSJS3_k127_9426597_22 525903.Taci_1580 1.066e-49 181.0 COG1528@1|root,COG1528@2|Bacteria,3TB3G@508458|Synergistetes 508458|Synergistetes P Iron-storage protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin HSJS3_k127_9426597_31 448385.sce3796 5.805e-28 124.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42TNB@68525|delta/epsilon subdivisions,2WQIG@28221|Deltaproteobacteria,2Z0TE@29|Myxococcales 28221|Deltaproteobacteria O FKBP-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C HSJS3_k127_9426597_21 670487.Ocepr_0982 5.003e-50 189.0 COG0730@1|root,COG0730@2|Bacteria,1WJ68@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE HSJS3_k127_9426597_38 1121085.AUCI01000002_gene4020 4.904e-06 51.0 2BFS6@1|root,329M0@2|Bacteria,1UBZZ@1239|Firmicutes,4INFW@91061|Bacilli,1ZNF2@1386|Bacillus 91061|Bacilli S OsmC-like protein - - - - - - - - - - - - OsmC HSJS3_k127_9426597_41 1232410.KI421412_gene336 0.0001157 47.0 29SGJ@1|root,2ZKKB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - HSJS3_k127_9426597_20 207954.MED92_12706 6.747e-51 185.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XK7A@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR HSJS3_k127_9426597_29 391625.PPSIR1_16930 3.225e-30 123.0 2EQTX@1|root,33IDK@2|Bacteria,1NJ7Q@1224|Proteobacteria,42XE5@68525|delta/epsilon subdivisions,2WTE3@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - SirB HSJS3_k127_9426597_13 587753.EY04_21300 2.261e-69 244.0 COG3217@1|root,COG3217@2|Bacteria,1REVG@1224|Proteobacteria,1SYD6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Fe-S protein ycbX - - ko:K07140 - - - - ko00000 - - - MOSC,MOSC_N HSJS3_k127_9426597_36 1082705.JIBP01000015_gene1167 3.164e-07 61.0 28HSZ@1|root,2Z7ZZ@2|Bacteria,1PKZD@1224|Proteobacteria,1RY25@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - HSJS3_k127_9426597_25 4558.Sb03g040680.1 1.246e-42 167.0 COG0596@1|root,KOG2382@2759|Eukaryota,37QUH@33090|Viridiplantae,3GAJV@35493|Streptophyta,3KW6S@4447|Liliopsida,3ICCW@38820|Poales 35493|Streptophyta S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 HSJS3_k127_9426597_14 1123487.KB892835_gene3511 2.253e-65 235.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,2KVC0@206389|Rhodocyclales 206389|Rhodocyclales S alpha/beta hydrolase fold - - - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 HSJS3_k127_9426597_6 861299.J421_2864 5.623e-121 399.0 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CBM_2,GSDH HSJS3_k127_9426597_17 330214.NIDE3500 4.63e-58 207.0 COG1704@1|root,COG1704@2|Bacteria 2|Bacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA HSJS3_k127_9426597_5 330214.NIDE3501 1.887e-142 478.0 COG4907@1|root,COG4907@2|Bacteria 2|Bacteria P membrane protein (DUF2207) yciQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF2207 HSJS3_k127_9426597_8 215803.DB30_6899 1.371e-93 324.0 COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,42Z17@68525|delta/epsilon subdivisions,2WURE@28221|Deltaproteobacteria,2YUPJ@29|Myxococcales 28221|Deltaproteobacteria O Peptidase family M28 - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 HSJS3_k127_9426597_16 204669.Acid345_4523 1.44e-60 229.0 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,3Y6D3@57723|Acidobacteria,2JKGW@204432|Acidobacteriia 2|Bacteria T diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GGDEF,PAS_4,SpoIIE HSJS3_k127_9426597_24 266117.Rxyl_2043 2.363e-43 160.0 COG2154@1|root,COG2154@2|Bacteria,2HPFQ@201174|Actinobacteria,4CQU3@84995|Rubrobacteria 84995|Rubrobacteria H Transcriptional coactivator pterin dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a HSJS3_k127_9426597_10 292564.Cyagr_2387 2.773e-81 283.0 COG0438@1|root,COG0438@2|Bacteria,1GIW7@1117|Cyanobacteria,22T9Z@167375|Cyanobium 1117|Cyanobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 HSJS3_k127_9426597_3 1242864.D187_009322 4.746e-164 537.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,42NNY@68525|delta/epsilon subdivisions,2X9B9@28221|Deltaproteobacteria,2YX2A@29|Myxococcales 28221|Deltaproteobacteria P POT family - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 HSJS3_k127_9426597_39 585423.KR49_13100 2.489e-05 57.0 COG0745@1|root,COG0745@2|Bacteria,1FZXT@1117|Cyanobacteria,1GZVR@1129|Synechococcus 1117|Cyanobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07669 ko02020,map02020 M00460 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C HSJS3_k127_9426597_40 644801.Psest_4302 5.951e-05 56.0 2A110@1|root,30P6F@2|Bacteria,1QDEK@1224|Proteobacteria,1T9D4@1236|Gammaproteobacteria,1Z2JF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19 HSJS3_k127_9426597_7 1191523.MROS_2246 2.611e-117 391.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 HSJS3_k127_9426597_26 946483.Cenrod_0353 1.542e-42 177.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase cda1 GO:0000003,GO:0000272,GO:0003006,GO:0005575,GO:0005618,GO:0005619,GO:0005623,GO:0005631,GO:0005975,GO:0005976,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006037,GO:0006039,GO:0006040,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009272,GO:0009277,GO:0009653,GO:0009987,GO:0010383,GO:0010927,GO:0016043,GO:0016052,GO:0016998,GO:0017144,GO:0019953,GO:0022402,GO:0022411,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030312,GO:0030435,GO:0030437,GO:0030476,GO:0031160,GO:0031505,GO:0032502,GO:0032505,GO:0032989,GO:0034218,GO:0034232,GO:0034293,GO:0042244,GO:0042546,GO:0042737,GO:0043170,GO:0043934,GO:0043935,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044277,GO:0044426,GO:0044462,GO:0044464,GO:0044703,GO:0045229,GO:0046348,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051321,GO:0051704,GO:0070590,GO:0070591,GO:0070726,GO:0070910,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0071853,GO:0071854,GO:0071940,GO:0071944,GO:0071966,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903046 1.7.3.3,3.5.1.104,3.5.1.41,3.5.2.5 ko:K00365,ko:K01452,ko:K16842,ko:K22278 ko00230,ko00232,ko00520,ko01100,ko01120,map00230,map00232,map00520,map01100,map01120 M00546 R02106,R02333,R02425,R07981 RC00166,RC00300,RC00680,RC02107,RC02551 ko00000,ko00001,ko00002,ko01000 - - - OHCU_decarbox,Polysacc_deac_1 HSJS3_k127_9426597_0 1089550.ATTH01000001_gene1799 1.372e-217 693.0 COG0517@1|root,COG2170@1|root,COG0517@2|Bacteria,COG2170@2|Bacteria,4NGW0@976|Bacteroidetes,1FIUK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Glutamate-cysteine ligase family 2(GCS2) - - - - - - - - - - - - CBS,GCS2 HSJS3_k127_9426597_12 1223410.KN050846_gene2792 1.964e-73 271.0 COG2988@1|root,COG2988@2|Bacteria,4NHWW@976|Bacteroidetes,1HZQK@117743|Flavobacteriia 976|Bacteroidetes E Succinylglutamate desuccinylase / Aspartoacylase family astE - 3.5.1.96 ko:K05526 ko00330,ko01100,map00330,map01100 - R00411 RC00064,RC00090 ko00000,ko00001,ko01000 - - - AstE_AspA HSJS3_k127_9426597_15 861299.J421_2930 1.106e-63 230.0 COG0673@1|root,COG0673@2|Bacteria,1ZSV9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Homoserine dehydrogenase, NAD binding domain - - - - - - - - - - - - GFO_IDH_MocA HSJS3_k127_9426597_19 861299.J421_2928 9.532e-52 207.0 COG2385@1|root,COG2385@2|Bacteria,1ZT25@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID HSJS3_k127_9426597_4 379066.GAU_1174 2.645e-150 488.0 COG0621@1|root,COG0621@2|Bacteria,1ZT70@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,UPF0004 HSJS3_k127_9426597_33 379066.GAU_1190 1.386e-23 110.0 COG2834@1|root,COG2834@2|Bacteria,1ZTXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Outer membrane lipoprotein carrier protein LolA - - - ko:K03634 - - - - ko00000 - - - LolA HSJS3_k127_9426597_2 379066.GAU_1921 1.653e-195 636.0 COG1674@1|root,COG1674@2|Bacteria,1ZSPI@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma HSJS3_k127_9426597_1 1379270.AUXF01000006_gene36 3.216e-205 646.0 COG0439@1|root,COG0439@2|Bacteria,1ZT0Q@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 HSJS3_k127_9426597_28 1379270.AUXF01000006_gene34 1.629e-33 142.0 COG0511@1|root,COG0511@2|Bacteria,1ZTR1@142182|Gemmatimonadetes 142182|Gemmatimonadetes I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl HSJS3_k127_9426597_18 518766.Rmar_0673 5.695e-56 201.0 COG0231@1|root,COG0231@2|Bacteria,4NDXA@976|Bacteroidetes,1FJ6E@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C HSJS3_k127_9426597_11 1379270.AUXF01000006_gene33 4.128e-81 282.0 COG0006@1|root,COG0006@2|Bacteria,1ZSTY@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Creatinase/Prolidase N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 HSJS3_k127_9426597_27 316278.SynRCC307_0456 1.684e-42 171.0 COG0757@1|root,COG0757@2|Bacteria,1G5X4@1117|Cyanobacteria,1H0NE@1129|Synechococcus 1117|Cyanobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II HSJS3_k127_9426597_34 1232410.KI421416_gene2555 3.637e-13 79.0 COG0457@1|root,COG0457@2|Bacteria,1Q1KD@1224|Proteobacteria,43EXE@68525|delta/epsilon subdivisions,2X2GF@28221|Deltaproteobacteria,43VAI@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 HSJS3_k127_9426597_30 1379698.RBG1_1C00001G0456 1.382e-29 136.0 COG0760@1|root,COG0760@2|Bacteria,2NP7B@2323|unclassified Bacteria 2|Bacteria O Peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03769,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3 HSJS3_k127_9426597_35 319795.Dgeo_0605 7.072e-11 65.0 COG1826@1|root,COG1826@2|Bacteria,1WKJH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 HSJS3_k127_9426597_37 1379270.AUXF01000006_gene28 9.89e-07 55.0 2FH8C@1|root,3492Q@2|Bacteria,1ZTXE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF4321) - - - - - - - - - - - - DUF4321 HSJS3_k127_9426597_9 379066.GAU_1932 2.723e-84 287.0 COG0142@1|root,COG0142@2|Bacteria,1ZT7D@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Polyprenyl synthetase - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt HSJS3_k127_9460070_0 1047013.AQSP01000125_gene2637 6.48e-48 195.0 COG0823@1|root,COG4946@1|root,COG0823@2|Bacteria,COG4946@2|Bacteria 2|Bacteria M serine-type peptidase activity tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N HSJS3_k127_9764987_13 643473.KB235930_gene540 2.812e-05 46.0 2A7FA@1|root,30WCV@2|Bacteria,1GFDD@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - HSJS3_k127_9764987_12 1121904.ARBP01000002_gene7227 1.692e-06 57.0 COG3637@1|root,COG3637@2|Bacteria,4NXWX@976|Bacteroidetes 976|Bacteroidetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl HSJS3_k127_9764987_6 861299.J421_2630 1.299e-16 83.0 COG0355@1|root,COG0355@2|Bacteria,1ZU1K@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N HSJS3_k127_9764987_0 861299.J421_2629 1.643e-238 744.0 COG0055@1|root,COG0055@2|Bacteria,1ZSNP@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N HSJS3_k127_9764987_2 861299.J421_2628 1.601e-87 297.0 COG0224@1|root,COG0224@2|Bacteria,1ZSZR@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt HSJS3_k127_9764987_1 861299.J421_2627 7.807e-222 699.0 COG0056@1|root,COG0056@2|Bacteria,1ZSNY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N HSJS3_k127_9764987_5 379066.GAU_2487 1.536e-29 124.0 COG0712@1|root,COG0712@2|Bacteria,1ZTP8@142182|Gemmatimonadetes 142182|Gemmatimonadetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP HSJS3_k127_9764987_8 1045858.Bint_2488 2.319e-13 80.0 COG0711@1|root,COG0711@2|Bacteria,2J9EE@203691|Spirochaetes 203691|Spirochaetes C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B HSJS3_k127_9764987_7 861299.J421_3946 6.845e-14 74.0 COG0636@1|root,COG0636@2|Bacteria,1ZU1W@142182|Gemmatimonadetes 142182|Gemmatimonadetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C HSJS3_k127_9764987_4 1379270.AUXF01000003_gene3427 5.931e-61 223.0 COG0356@1|root,COG0356@2|Bacteria,1ZSQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A HSJS3_k127_9764987_11 1379270.AUXF01000003_gene3425 1.297e-06 55.0 2DFBE@1|root,2ZR6K@2|Bacteria,1ZU7V@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 HSJS3_k127_9764987_3 1379698.RBG1_1C00001G0201 2.891e-80 273.0 COG0714@1|root,COG0714@2|Bacteria,2NNV8@2323|unclassified Bacteria 2|Bacteria O ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 HSJS3_k127_9873432_4 518766.Rmar_2133 2.137e-85 295.0 COG1629@1|root,COG4771@2|Bacteria,4NFKZ@976|Bacteroidetes,1FIJR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec HSJS3_k127_9873432_2 1122603.ATVI01000006_gene518 1.566e-121 396.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1X42V@135614|Xanthomonadales 135614|Xanthomonadales H polyphosphate kinase - - - - - - - - - - - - PPK2 HSJS3_k127_9873432_12 290317.Cpha266_2735 5.775e-34 141.0 COG0705@1|root,COG0705@2|Bacteria,1FDF1@1090|Chlorobi 1090|Chlorobi S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid HSJS3_k127_9873432_0 379066.GAU_0803 2.51e-199 662.0 COG2091@1|root,COG2091@2|Bacteria,1ZUQA@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - HSJS3_k127_9873432_1 269799.Gmet_0138 8.472e-149 484.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139,DUF4140 HSJS3_k127_9873432_5 443143.GM18_1507 4.95e-68 255.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42S6I@68525|delta/epsilon subdivisions,2WNNW@28221|Deltaproteobacteria 28221|Deltaproteobacteria P TOBE domain - - 3.6.3.29,3.6.3.55 ko:K02017,ko:K06857 ko02010,map02010 M00186,M00189 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.2,3.A.1.6.4,3.A.1.8 - - ABC_tran,TOBE HSJS3_k127_9873432_10 671143.DAMO_1144 7.973e-54 202.0 COG4662@1|root,COG4662@2|Bacteria,2NPF5@2323|unclassified Bacteria 2|Bacteria H Binding-protein-dependent transport system inner membrane component tupB - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 HSJS3_k127_9873432_8 525904.Tter_1459 3e-57 215.0 COG2998@1|root,COG2998@2|Bacteria,2NP4U@2323|unclassified Bacteria 2|Bacteria H PBP superfamily domain tupB - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 HSJS3_k127_9873432_9 861299.J421_2074 2.259e-56 213.0 COG1668@1|root,COG1668@2|Bacteria,1ZTID@142182|Gemmatimonadetes 142182|Gemmatimonadetes CP ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 HSJS3_k127_9873432_3 1382359.JIAL01000001_gene3045 3.968e-86 295.0 COG4152@1|root,COG4152@2|Bacteria,3Y2NV@57723|Acidobacteria,2JHVX@204432|Acidobacteriia 204432|Acidobacteriia S pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 HSJS3_k127_9873432_11 1049564.TevJSym_at00410 9.438e-42 167.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1J4ZD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran HSJS3_k127_9873432_7 861299.J421_3994 6.674e-62 221.0 COG3417@1|root,COG3417@2|Bacteria 2|Bacteria M Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) lpoB GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07337,ko:K21008 ko02025,map02025 - - - ko00000,ko00001 - - - LpoB HSJS3_k127_9873432_14 1296416.JACB01000044_gene4967 2.313e-09 70.0 COG3014@1|root,COG3014@2|Bacteria,4NIIU@976|Bacteroidetes,1I0JV@117743|Flavobacteriia,2YITE@290174|Aquimarina 976|Bacteroidetes S protein conserved in bacteria - - - ko:K09859 - - - - ko00000 - - - TPR_2 HSJS3_k127_9873432_15 1217710.F969_03723 2.98e-05 57.0 COG3014@1|root,COG3014@2|Bacteria,1PD4S@1224|Proteobacteria,1RQ8Y@1236|Gammaproteobacteria,3NK73@468|Moraxellaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09859 - - - - ko00000 - - - - HSJS3_k127_9873432_13 379066.GAU_1277 1.136e-18 88.0 COG0457@1|root,COG0697@1|root,COG0457@2|Bacteria,COG0697@2|Bacteria,1ZT9A@142182|Gemmatimonadetes 142182|Gemmatimonadetes EG Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 ## 1666 queries scanned ## Total time (seconds): 132.52965426445007 ## Rate: 12.57 q/s