## Sat Nov 16 01:35:46 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin12/LZS_2_bin.24.fa -m mmseqs --itype genome -o LZS_2_bin.24 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/LZS_2_bin.24 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
LZS2_k127_1008021_0	768671.ThimaDRAFT_4427	4.921e-38	161.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,1S900@1236|Gammaproteobacteria,1WZQJ@135613|Chromatiales	135613|Chromatiales	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
LZS2_k127_1008021_1	1123020.AUIE01000005_gene4378	1.422e-30	128.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1YCX3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	sagS	-	2.7.13.3	ko:K20973	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
LZS2_k127_1088188_13	330214.NIDE1352	1.063e-08	63.0	COG4796@1|root,COG4796@2|Bacteria,3J0Q9@40117|Nitrospirae	40117|Nitrospirae	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	Secretin,Secretin_N
LZS2_k127_1088188_8	330214.NIDE1351	3.97e-57	207.0	COG3168@1|root,COG3168@2|Bacteria,3J1AT@40117|Nitrospirae	40117|Nitrospirae	NU	Pilus assembly protein, PilP	-	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
LZS2_k127_1088188_5	330214.NIDE1350	3.822e-77	264.0	COG3167@1|root,COG3167@2|Bacteria,3J1BH@40117|Nitrospirae	40117|Nitrospirae	NU	Pilus assembly protein, PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
LZS2_k127_1088188_6	330214.NIDE1349	1.213e-75	257.0	COG3166@1|root,COG3166@2|Bacteria,3J1EX@40117|Nitrospirae	40117|Nitrospirae	NU	Fimbrial assembly protein (PilN)	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
LZS2_k127_1088188_2	330214.NIDE1348	4.952e-158	505.0	COG4972@1|root,COG4972@2|Bacteria,3J177@40117|Nitrospirae	40117|Nitrospirae	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
LZS2_k127_1088188_12	330214.NIDE1347	2.447e-17	83.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	racA	-	-	ko:K11686,ko:K13640,ko:K18997	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	DUF1836,MerR_1,MerR_2
LZS2_k127_1088188_3	330214.NIDE1346	1.736e-134	435.0	COG1660@1|root,COG1660@2|Bacteria,3J0IK@40117|Nitrospirae	40117|Nitrospirae	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
LZS2_k127_1088188_11	330214.NIDE1345	2.929e-32	129.0	COG1544@1|root,COG1544@2|Bacteria,3J0V7@40117|Nitrospirae	40117|Nitrospirae	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
LZS2_k127_1088188_0	330214.NIDE1344	1.04e-226	711.0	COG1508@1|root,COG1508@2|Bacteria,3J0AT@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
LZS2_k127_1088188_4	330214.NIDE1343	1.724e-120	391.0	COG1137@1|root,COG1137@2|Bacteria,3J0GJ@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
LZS2_k127_1088188_10	330214.NIDE1342	3.39e-39	154.0	COG1934@1|root,COG1934@2|Bacteria,3J1EG@40117|Nitrospirae	40117|Nitrospirae	S	OstA-like protein	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
LZS2_k127_1088188_7	330214.NIDE1341	5.984e-63	221.0	COG5375@1|root,COG5375@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
LZS2_k127_1088188_9	330214.NIDE1340	4.667e-56	199.0	COG0203@1|root,COG0203@2|Bacteria,3J0TE@40117|Nitrospirae	40117|Nitrospirae	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
LZS2_k127_1088188_1	330214.NIDE1339	3.172e-158	502.0	COG0202@1|root,COG0202@2|Bacteria,3J0AR@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
LZS2_k127_1119645_3	330214.NIDE2249	0.0001179	51.0	COG1974@1|root,COG1974@2|Bacteria,3J1C0@40117|Nitrospirae	2|Bacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response)	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
LZS2_k127_1119645_0	706587.Desti_1935	1.83e-38	153.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
LZS2_k127_1124123_1	330214.NIDE3365	6.908e-66	227.0	COG0683@1|root,COG0683@2|Bacteria,3J18U@40117|Nitrospirae	40117|Nitrospirae	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
LZS2_k127_1124123_2	1485545.JQLW01000009_gene160	1.554e-53	197.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria	1224|Proteobacteria	S	Peptidase M50	MA20_27160	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
LZS2_k127_1124123_0	330214.NIDE3366	3.102e-175	554.0	COG0180@1|root,COG0180@2|Bacteria,3J0A0@40117|Nitrospirae	40117|Nitrospirae	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
LZS2_k127_1138806_3	330214.NIDE3859	4.125e-69	239.0	COG0071@1|root,COG0071@2|Bacteria,3J0TV@40117|Nitrospirae	40117|Nitrospirae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
LZS2_k127_1138806_1	330214.NIDE3860	4.778e-82	278.0	COG1926@1|root,COG1926@2|Bacteria,3J18T@40117|Nitrospirae	40117|Nitrospirae	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
LZS2_k127_1138806_2	330214.NIDE3861	5.616e-75	256.0	COG1499@1|root,COG1499@2|Bacteria	2|Bacteria	J	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NMD3
LZS2_k127_1138806_0	330214.NIDE3863	4.859e-87	296.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_1138806_5	330214.NIDE3864	1.374e-21	98.0	COG2010@1|root,COG2010@2|Bacteria,3J1AX@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_1146552_12	330214.NIDE4323	2.87e-58	205.0	COG3565@1|root,COG3565@2|Bacteria	2|Bacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
LZS2_k127_1146552_7	330214.NIDE4322	3.096e-99	331.0	COG0744@1|root,COG0744@2|Bacteria,3J127@40117|Nitrospirae	40117|Nitrospirae	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
LZS2_k127_1146552_11	330214.NIDE4321	8.708e-62	219.0	COG0218@1|root,COG0218@2|Bacteria,3J1D5@40117|Nitrospirae	40117|Nitrospirae	D	Necessary for normal cell division and for the maintenance of normal septation	-	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
LZS2_k127_1146552_6	330214.NIDE4320	2.273e-99	333.0	COG0760@1|root,COG0760@2|Bacteria,3J0SR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N
LZS2_k127_1146552_5	330214.NIDE4319	7.42e-104	346.0	COG0760@1|root,COG0760@2|Bacteria,3J16U@40117|Nitrospirae	40117|Nitrospirae	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
LZS2_k127_1146552_0	330214.NIDE4318	0.0	1600.0	COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae	40117|Nitrospirae	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
LZS2_k127_1146552_10	330214.NIDE4317	5.145e-67	232.0	COG0615@1|root,COG0615@2|Bacteria,3J0JP@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,Hydrolase_3
LZS2_k127_1146552_2	103690.17132895	4.769e-169	571.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2203@1|root,COG5278@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5278@2|Bacteria,1G09B@1117|Cyanobacteria,1HMD7@1161|Nostocales	1117|Cyanobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
LZS2_k127_1146552_13	330214.NIDE4315	8.949e-53	193.0	COG3091@1|root,COG3091@2|Bacteria	2|Bacteria	K	SprT-like family	sprT	-	-	ko:K02742	-	-	-	-	ko00000	-	-	-	SprT-like,Zn_ribbon_SprT
LZS2_k127_1146552_3	330214.NIDE4314	3.732e-153	492.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1146552_8	330214.NIDE4313	1.854e-86	289.0	COG0279@1|root,COG0279@2|Bacteria,3J0HG@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
LZS2_k127_1146552_4	330214.NIDE4312	1.648e-148	475.0	COG0330@1|root,COG0330@2|Bacteria,3J0NF@40117|Nitrospirae	40117|Nitrospirae	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
LZS2_k127_1146552_14	330214.NIDE4311	6.088e-46	173.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
LZS2_k127_1146552_1	330214.NIDE4310	2.56e-177	564.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE4310|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1146552_15	330214.NIDE4308	2.856e-43	162.0	COG0824@1|root,COG0824@2|Bacteria,3J1EV@40117|Nitrospirae	40117|Nitrospirae	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
LZS2_k127_1146552_16	1125973.JNLC01000014_gene2478	1.652e-35	146.0	COG0500@1|root,COG2226@2|Bacteria,1N5QH@1224|Proteobacteria,2UM5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
LZS2_k127_1146552_17	1156919.QWC_12116	4.579e-19	101.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2VKC4@28216|Betaproteobacteria,3T44P@506|Alcaligenaceae	28216|Betaproteobacteria	N	Flagellar motor protein	motB1	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
LZS2_k127_1147782_0	330214.NIDE0426	5.622e-311	957.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,3J0CA@40117|Nitrospirae	40117|Nitrospirae	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
LZS2_k127_1147782_6	330214.NIDE0427	6.892e-136	437.0	COG0616@1|root,COG0616@2|Bacteria,3J0J0@40117|Nitrospirae	40117|Nitrospirae	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
LZS2_k127_1147782_16	330214.NIDE0428	8.432e-48	172.0	COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
LZS2_k127_1147782_4	330214.NIDE0429	3.456e-156	498.0	2C1IB@1|root,2ZG3S@2|Bacteria	2|Bacteria	S	Proto-chlorophyllide reductase 57 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	PCP_red
LZS2_k127_1147782_2	330214.NIDE0431	6.654e-185	584.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,VCBS
LZS2_k127_1147782_10	330214.NIDE0434	1.367e-111	368.0	COG1686@1|root,COG1686@2|Bacteria,3J179@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
LZS2_k127_1147782_1	330214.NIDE0440	3.077e-224	699.0	COG0334@1|root,COG0334@2|Bacteria	2|Bacteria	E	glutamate dehydrogenase [NAD(P)+] activity	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
LZS2_k127_1147782_15	330214.NIDE0441	3.653e-50	188.0	COG0321@1|root,COG0321@2|Bacteria	2|Bacteria	H	lipoyl(octanoyl) transferase activity	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181,2.8.1.8	ko:K03644,ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07767,R07768,R07769	RC00039,RC00992,RC01978,RC02867	ko00000,ko00001,ko01000	-	-	iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	BPL_LplA_LipB
LZS2_k127_1147782_3	330214.NIDE0443	9.407e-159	511.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
LZS2_k127_1147782_11	1131269.AQVV01000011_gene2489	1.729e-92	310.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
LZS2_k127_1147782_7	289376.THEYE_A0592	9.959e-131	431.0	COG1030@1|root,COG1030@2|Bacteria,3J0WF@40117|Nitrospirae	40117|Nitrospirae	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
LZS2_k127_1147782_5	330214.NIDE0444	7.915e-137	441.0	COG2519@1|root,COG2519@2|Bacteria,3J0PT@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
LZS2_k127_1147782_8	330214.NIDE0445	1.408e-117	382.0	COG1028@1|root,COG1028@2|Bacteria	330214.NIDE0445|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1147782_9	330214.NIDE0446	3.822e-116	381.0	COG0169@1|root,COG0169@2|Bacteria,3J0SM@40117|Nitrospirae	40117|Nitrospirae	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
LZS2_k127_1147782_13	330214.NIDE0447	1.825e-67	233.0	COG0703@1|root,COG0703@2|Bacteria,3J0R8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
LZS2_k127_1155250_1	479434.Sthe_3349	1.626e-07	53.0	COG1002@1|root,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
LZS2_k127_1155250_0	338966.Ppro_0793	2.717e-55	200.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,43UAC@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB-2	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
LZS2_k127_1158346_1	330214.NIDE2257	1.481e-66	238.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
LZS2_k127_1158346_0	330214.NIDE2255	3.235e-104	349.0	COG0412@1|root,COG0412@2|Bacteria,3J1B9@40117|Nitrospirae	40117|Nitrospirae	Q	Alpha/beta hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
LZS2_k127_1158346_3	330214.NIDE2253	7.321e-38	145.0	COG2363@1|root,COG2363@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF423)	ygdD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF423
LZS2_k127_1161244_0	330214.NIDE2177	2.867e-107	358.0	COG3182@1|root,COG3182@2|Bacteria	2|Bacteria	E	Iron-regulated membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PepSY,PepSY_TM
LZS2_k127_1161244_2	671143.DAMO_2920	7.262e-11	69.0	2DRSH@1|root,33CVS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1161244_3	1408254.T458_07445	5.871e-06	52.0	COG0515@1|root,COG4191@1|root,COG0515@2|Bacteria,COG4191@2|Bacteria,1VR57@1239|Firmicutes,4HUYX@91061|Bacilli,26VPY@186822|Paenibacillaceae	91061|Bacilli	K	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Pkinase
LZS2_k127_1161244_1	321327.CYA_2186	6.982e-57	201.0	COG0722@1|root,COG0722@2|Bacteria,1G35W@1117|Cyanobacteria,1GYEV@1129|Synechococcus	1117|Cyanobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
LZS2_k127_1165154_6	330214.NIDE1923	1.14e-08	57.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
LZS2_k127_1165154_4	292563.Cyast_1605	1.823e-32	143.0	COG1357@1|root,COG1357@2|Bacteria,1G1VX@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
LZS2_k127_1165154_0	330214.NIDE3777	2.49e-189	600.0	COG1488@1|root,COG1488@2|Bacteria	2|Bacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	iYO844.BSU31750	NAPRTase
LZS2_k127_1165154_1	330214.NIDE3776	2.376e-65	229.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.11.1,3.5.1.19	ko:K08281,ko:K12132	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000,ko01001	-	-	iE2348C_1286.E2348C_1895,iECs_1301.ECs2475,iZ_1308.Z2802	Isochorismatase
LZS2_k127_1165154_3	330214.NIDE3775	6.725e-40	153.0	COG2010@1|root,COG2010@2|Bacteria,3J1AX@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_1165154_2	330214.NIDE1922	1.652e-42	160.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_1168289_2	330214.NIDE2547	1.929e-08	56.0	COG1912@1|root,COG1912@2|Bacteria,3J0RG@40117|Nitrospirae	40117|Nitrospirae	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
LZS2_k127_1168289_1	330214.NIDE2546	1.815e-75	256.0	COG0782@1|root,COG0782@2|Bacteria,3J0NA@40117|Nitrospirae	40117|Nitrospirae	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
LZS2_k127_1168289_0	330214.NIDE2545	0.0	1625.0	COG0458@1|root,COG0458@2|Bacteria,3J0BC@40117|Nitrospirae	40117|Nitrospirae	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
LZS2_k127_1186052_1	748247.AZKH_0156	2.701e-72	245.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VRX6@28216|Betaproteobacteria,2KWX0@206389|Rhodocyclales	206389|Rhodocyclales	S	Glyoxalase-like domain	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
LZS2_k127_1186052_2	452637.Oter_1314	4.292e-55	194.0	COG5507@1|root,COG5507@2|Bacteria,46VQ8@74201|Verrucomicrobia,3K9QM@414999|Opitutae	414999|Opitutae	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
LZS2_k127_1186052_0	1403819.BATR01000092_gene2754	2.411e-111	372.0	COG3174@1|root,COG3174@2|Bacteria,46VTJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
LZS2_k127_1186052_3	330214.NIDE3827	2.118e-52	192.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
LZS2_k127_1186052_4	330214.NIDE1844	1.683e-43	164.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	ko:K11932	-	-	-	-	ko00000	-	-	-	Usp
LZS2_k127_1209167_2	1340493.JNIF01000004_gene859	4.875e-140	462.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
LZS2_k127_1209167_11	1396418.BATQ01000078_gene616	1.326e-45	183.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	SLH
LZS2_k127_1209167_17	512565.AMIS_44900	4.165e-05	46.0	COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4D8NI@85008|Micromonosporales	201174|Actinobacteria	P	Sulfatase	atsB	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF1269,Sulfatase
LZS2_k127_1209167_13	234267.Acid_4851	3.574e-19	95.0	COG2149@1|root,COG2149@2|Bacteria,3Y60S@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
LZS2_k127_1209167_3	1267533.KB906737_gene1892	2.759e-125	412.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
LZS2_k127_1209167_9	1340493.JNIF01000004_gene1090	9.096e-53	196.0	COG1414@1|root,COG1414@2|Bacteria,3Y8GE@57723|Acidobacteria	57723|Acidobacteria	K	Bacterial transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
LZS2_k127_1209167_0	1267535.KB906767_gene1827	1.231e-155	533.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
LZS2_k127_1209167_16	1267535.KB906767_gene1629	1.241e-16	95.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,Glyco_hydro_125
LZS2_k127_1209167_4	1123242.JH636435_gene2114	9.502e-114	379.0	COG4948@1|root,COG4948@2|Bacteria,2IX5W@203682|Planctomycetes	203682|Planctomycetes	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
LZS2_k127_1209167_10	1122919.KB905586_gene3823	1.102e-48	183.0	COG2120@1|root,COG2120@2|Bacteria,1TUFR@1239|Firmicutes,4I855@91061|Bacilli,26YXG@186822|Paenibacillaceae	91061|Bacilli	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
LZS2_k127_1209167_8	1382306.JNIM01000001_gene2724	2.205e-57	210.0	COG1028@1|root,COG1028@2|Bacteria,2G8K5@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100,1.5.1.33	ko:K00059,ko:K03793	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
LZS2_k127_1209167_6	886293.Sinac_7379	1.679e-85	288.0	COG0684@1|root,COG0684@2|Bacteria,2J4VR@203682|Planctomycetes	203682|Planctomycetes	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
LZS2_k127_1209167_1	497964.CfE428DRAFT_1070	8.844e-149	486.0	COG5476@1|root,COG5476@2|Bacteria,46SE7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
LZS2_k127_1209167_7	313603.FB2170_08124	6.369e-77	278.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1HXMU@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	sglT	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
LZS2_k127_1209167_5	1267535.KB906767_gene1633	9.614e-89	304.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	araB	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	HTH_IclR,IclR,SGL,adh_short
LZS2_k127_1209167_15	543728.Vapar_0665	5.291e-17	85.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2VKSJ@28216|Betaproteobacteria,4ACTJ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
LZS2_k127_1209167_18	1323663.AROI01000038_gene1279	9.331e-05	47.0	COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,1SE0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
LZS2_k127_1209167_12	234267.Acid_1280	8.792e-21	106.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
LZS2_k127_1218589_2	330214.NIDE0408	1.855e-61	215.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
LZS2_k127_1218589_0	330214.NIDE0407	0.0	1288.0	COG0155@1|root,COG0425@1|root,COG0155@2|Bacteria,COG0425@2|Bacteria,3J11D@40117|Nitrospirae	40117|Nitrospirae	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.7.1.15,1.8.7.1	ko:K00362,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00530	R00787,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
LZS2_k127_1218589_3	330214.NIDE0406	4.518e-46	170.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	iscR	-	2.8.1.7	ko:K04487,ko:K13643	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03000,ko03016,ko03029	-	-	-	Rrf2
LZS2_k127_1218589_4	330214.NIDE0405	7.821e-42	161.0	COG2901@1|root,COG2901@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03557,ko:K07712	ko02020,ko05111,map02020,map05111	M00497	-	-	ko00000,ko00001,ko00002,ko02022,ko03000,ko03036,ko03400	-	-	-	HTH_8
LZS2_k127_1218589_5	330214.NIDE0404	1.632e-39	149.0	COG0776@1|root,COG0776@2|Bacteria,3J0V6@40117|Nitrospirae	40117|Nitrospirae	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
LZS2_k127_1218589_1	330214.NIDE0403	4.06e-299	924.0	COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
LZS2_k127_122359_1	330214.NIDE3246	6.526e-68	243.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	ABC_sub_bind,GAF_2,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9
LZS2_k127_122359_5	323848.Nmul_A0940	6.867e-24	106.0	COG0531@1|root,COG0531@2|Bacteria,1MX13@1224|Proteobacteria,2WFHQ@28216|Betaproteobacteria,371XS@32003|Nitrosomonadales	28216|Betaproteobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
LZS2_k127_122359_0	330214.NIDE0843	3.821e-302	933.0	COG1032@1|root,COG1032@2|Bacteria,3J18Y@40117|Nitrospirae	40117|Nitrospirae	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
LZS2_k127_122359_4	316067.Geob_2073	7.655e-26	110.0	COG4118@1|root,COG4118@2|Bacteria,1NM68@1224|Proteobacteria,42XA0@68525|delta/epsilon subdivisions,2WT8W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
LZS2_k127_122359_2	316067.Geob_2074	1.824e-45	168.0	COG1569@1|root,COG1569@2|Bacteria,1QSUM@1224|Proteobacteria,42WJR@68525|delta/epsilon subdivisions,2WRT9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
LZS2_k127_1228251_2	330214.NIDE3967	8.257e-26	110.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
LZS2_k127_1228251_0	330214.NIDE3968	2.654e-193	617.0	COG2274@1|root,COG2274@2|Bacteria	2|Bacteria	V	protein secretion by the type I secretion system	-	-	-	ko:K02021	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS2_k127_1228251_1	330214.NIDE3966	7.217e-176	563.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cvaA	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
LZS2_k127_1237751_8	190650.CC_0675	3.92e-08	63.0	2DG5B@1|root,2ZUJY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1237751_7	1265502.KB905929_gene2319	2.765e-26	116.0	COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2VIJS@28216|Betaproteobacteria,4AHI8@80864|Comamonadaceae	28216|Betaproteobacteria	M	OmpA family	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	BON,OmpA
LZS2_k127_1237751_1	1123392.AQWL01000002_gene1831	9.257e-112	377.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
LZS2_k127_1237751_6	330214.NIDE2593	2.192e-38	148.0	2DCFZ@1|root,2ZDZV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1237751_4	330214.NIDE1235	2.331e-69	241.0	COG0386@1|root,COG0386@2|Bacteria	2|Bacteria	O	Belongs to the glutathione peroxidase family	btuE	-	1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	iJN678.slr1992	GSHPx
LZS2_k127_1237751_2	330214.NIDE0443	2.536e-110	370.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
LZS2_k127_1237751_5	1288494.EBAPG3_19400	3.831e-67	244.0	COG0412@1|root,COG0412@2|Bacteria,1PSEB@1224|Proteobacteria,2VUDB@28216|Betaproteobacteria,373SI@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
LZS2_k127_1237751_0	857087.Metme_1146	1.669e-155	499.0	COG4782@1|root,COG4782@2|Bacteria,1MXVC@1224|Proteobacteria,1RYK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha/beta hydrolase of unknown function (DUF900)	-	-	-	-	-	-	-	-	-	-	-	-	DUF900
LZS2_k127_1237751_3	1173025.GEI7407_3200	6.398e-79	276.0	COG1231@1|root,COG1231@2|Bacteria,1G18A@1117|Cyanobacteria,1H6YY@1150|Oscillatoriales	1117|Cyanobacteria	E	Monoamine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
LZS2_k127_1240180_5	330214.NIDE3268	1.234e-82	276.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
LZS2_k127_1240180_16	1254432.SCE1572_01100	7.679e-15	76.0	COG2405@1|root,COG2405@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1240180_15	324925.Ppha_0279	6.129e-16	80.0	COG3668@1|root,COG3668@2|Bacteria,1FFP3@1090|Chlorobi	1090|Chlorobi	S	PFAM plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
LZS2_k127_1240180_10	330214.NIDE1627	9.442e-36	136.0	2DR98@1|root,33ARN@2|Bacteria	2|Bacteria	S	Putative addiction module component	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
LZS2_k127_1240180_9	103733.JNYO01000056_gene1108	5.975e-39	157.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
LZS2_k127_1240180_4	760117.JN27_07085	5.553e-104	351.0	COG2133@1|root,COG2133@2|Bacteria,1R86D@1224|Proteobacteria,2VTBE@28216|Betaproteobacteria,475Z6@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
LZS2_k127_1240180_0	330214.NIDE3266	0.0	1172.0	COG3808@1|root,COG3808@2|Bacteria	2|Bacteria	C	hydrogen-translocating pyrophosphatase activity	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
LZS2_k127_1240180_3	330214.NIDE3264	1.382e-230	729.0	COG0608@1|root,COG0608@2|Bacteria,3J0PF@40117|Nitrospirae	40117|Nitrospirae	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
LZS2_k127_1240180_1	330214.NIDE3263	0.0	1145.0	COG0317@1|root,COG0317@2|Bacteria,3J0CX@40117|Nitrospirae	40117|Nitrospirae	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
LZS2_k127_1240180_7	330214.NIDE3261	9.787e-46	172.0	COG1430@1|root,COG1430@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
LZS2_k127_1240180_6	330214.NIDE3258	3.216e-76	262.0	COG0655@1|root,COG0655@2|Bacteria,3J192@40117|Nitrospirae	40117|Nitrospirae	S	NADPH-dependent FMN reductase	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
LZS2_k127_1240180_14	330214.NIDE3257	1.377e-17	83.0	COG2906@1|root,COG2906@2|Bacteria	2|Bacteria	P	2 iron, 2 sulfur cluster binding	bfd	GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
LZS2_k127_1240180_2	330214.NIDE3226	1.513e-269	846.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
LZS2_k127_1246790_0	330214.NIDE3384	0.0	1562.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,3J0SV@40117|Nitrospirae	40117|Nitrospirae	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
LZS2_k127_1246790_5	330214.NIDE3385	2.78e-162	516.0	COG0142@1|root,COG0142@2|Bacteria,3J0H0@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
LZS2_k127_1246790_4	330214.NIDE3386	8.232e-181	576.0	COG4198@1|root,COG4198@2|Bacteria,3J0IE@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
LZS2_k127_1246790_2	330214.NIDE3387	2.336e-205	647.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_1246790_7	330214.NIDE3388	1.173e-111	366.0	COG1208@1|root,COG1208@2|Bacteria,3J0QW@40117|Nitrospirae	40117|Nitrospirae	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
LZS2_k127_1246790_6	330214.NIDE3389	1.192e-152	490.0	COG3178@1|root,COG3178@2|Bacteria,3J15Y@40117|Nitrospirae	40117|Nitrospirae	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
LZS2_k127_1246790_8	330214.NIDE3391	7.772e-28	117.0	COG5652@1|root,COG5652@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
LZS2_k127_1246790_1	330214.NIDE3392	1.372e-314	979.0	COG1449@1|root,COG1449@2|Bacteria,3J0AQ@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
LZS2_k127_1246790_3	330214.NIDE3393	9.222e-186	586.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
LZS2_k127_1247369_3	1385935.N836_10705	6.48e-22	102.0	2ETWY@1|root,32VZU@2|Bacteria,1G9Y9@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1247369_2	1123276.KB893246_gene602	4.656e-39	148.0	COG0607@1|root,COG0607@2|Bacteria,4NQ61@976|Bacteroidetes,47Q3A@768503|Cytophagia	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
LZS2_k127_1248230_0	330214.NIDE4091	2.377e-266	844.0	COG3419@1|root,COG3419@2|Bacteria,3J100@40117|Nitrospirae	40117|Nitrospirae	NU	Tfp pilus assembly protein tip-associated adhesin	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
LZS2_k127_1248230_9	330214.NIDE4090	2.674e-60	220.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,HYR,Laminin_G_3,RHS_repeat,SprB
LZS2_k127_1248230_4	330214.NIDE4089	1.437e-164	524.0	COG1702@1|root,COG1702@2|Bacteria,3J0AD@40117|Nitrospirae	40117|Nitrospirae	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
LZS2_k127_1248230_12	330214.NIDE4088	5.704e-42	159.0	COG0319@1|root,COG0319@2|Bacteria,3J0US@40117|Nitrospirae	40117|Nitrospirae	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
LZS2_k127_1248230_5	330214.NIDE4087	1.739e-121	398.0	COG0552@1|root,COG0552@2|Bacteria,3J0GY@40117|Nitrospirae	40117|Nitrospirae	D	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
LZS2_k127_1248230_7	330214.NIDE4086	1.055e-89	302.0	COG0745@1|root,COG2204@1|root,COG0745@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
LZS2_k127_1248230_1	330214.NIDE4085	1.837e-208	671.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0348	Cofac_haem_bdg,PDZ_2,Peptidase_M1,Peptidase_M28
LZS2_k127_1248230_3	330214.NIDE4084	7.004e-176	558.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PA,PD40,PDZ_2,Peptidase_M28
LZS2_k127_1248230_11	330214.NIDE4083	9.711e-51	195.0	COG0671@1|root,COG0671@2|Bacteria,3J1CX@40117|Nitrospirae	40117|Nitrospirae	I	PAP2 superfamily	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
LZS2_k127_1248230_2	330214.NIDE4082	2.291e-201	642.0	COG1807@1|root,COG1807@2|Bacteria,3J12H@40117|Nitrospirae	40117|Nitrospirae	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1248230_13	330214.NIDE4081	5.243e-40	150.0	COG3952@1|root,COG3952@2|Bacteria	2|Bacteria	S	lipid-A-disaccharide synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
LZS2_k127_1248230_14	1461577.CCMH01000013_gene717	4.778e-28	117.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I4A2@117743|Flavobacteriia	976|Bacteroidetes	M	30S ribosomal protein S23	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS2_k127_1248230_6	330214.NIDE4080	3.397e-103	341.0	COG0463@1|root,COG0463@2|Bacteria,3J13C@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS2_k127_1248230_16	1380391.JIAS01000012_gene4183	3.743e-09	64.0	28K7D@1|root,2Z9VI@2|Bacteria,1R8BZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1248230_10	66874.JOFS01000001_gene860	1.287e-56	206.0	COG0500@1|root,COG0500@2|Bacteria,2HFN5@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
LZS2_k127_1248230_8	330214.NIDE3495	1.627e-73	248.0	COG3793@1|root,COG3793@2|Bacteria	2|Bacteria	P	PFAM Mo-dependent nitrogenase	-	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	TerB,TerB_C,TerB_N
LZS2_k127_1251577_5	1385515.N791_10915	1.792e-34	134.0	COG0346@1|root,COG0346@2|Bacteria,1RHM9@1224|Proteobacteria,1S6Y3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
LZS2_k127_1251577_3	545264.KB898749_gene28	2.01e-84	284.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,1S7W4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
LZS2_k127_1251577_0	472759.Nhal_0245	8.862e-161	512.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,1X2E9@135613|Chromatiales	135613|Chromatiales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
LZS2_k127_1251577_8	1123508.JH636440_gene2834	2.917e-18	86.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1251577_6	13035.Dacsa_2902	1.56e-28	115.0	COG1724@1|root,COG1724@2|Bacteria,1G9SX@1117|Cyanobacteria	1117|Cyanobacteria	N	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
LZS2_k127_1251577_4	28229.ND2E_3858	1.143e-81	276.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,2Q8BE@267889|Colwelliaceae	1236|Gammaproteobacteria	Q	Thiopurine S-methyltransferase (TPMT)	tpm	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
LZS2_k127_1251577_2	330214.NIDE1756	2.048e-110	363.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
LZS2_k127_1251577_9	765913.ThidrDRAFT_3902	3.896e-08	66.0	COG3475@1|root,COG3475@2|Bacteria,1NI2D@1224|Proteobacteria,1TKC2@1236|Gammaproteobacteria,1X1RH@135613|Chromatiales	135613|Chromatiales	M	LICD family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1251577_1	330214.NIDE1756	3.213e-125	406.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
LZS2_k127_1251577_7	1379270.AUXF01000003_gene3755	2.739e-19	102.0	28M10@1|root,2ZAFW@2|Bacteria,1ZSP7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF4403)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4403
LZS2_k127_1257755_0	330214.NIDE2288	1.766e-219	691.0	COG1766@1|root,COG1766@2|Bacteria,3J0A6@40117|Nitrospirae	40117|Nitrospirae	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
LZS2_k127_1257755_1	330214.NIDE2289	2.966e-99	331.0	COG1536@1|root,COG1536@2|Bacteria,3J0GZ@40117|Nitrospirae	40117|Nitrospirae	N	FliG middle domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
LZS2_k127_1262842_3	330214.NIDE0522	1.993e-38	145.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Lactamase_B_2
LZS2_k127_1262842_1	330214.NIDE0521	1.525e-133	430.0	COG2912@1|root,COG2912@2|Bacteria	2|Bacteria	P	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
LZS2_k127_1262842_0	330214.NIDE0520	1.909e-142	454.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	ycf38	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
LZS2_k127_1262842_2	330214.NIDE0519	6.311e-56	198.0	COG1131@1|root,COG1131@2|Bacteria,3J0JF@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_1264001_2	330214.NIDE2356	4.182e-108	353.0	COG1291@1|root,COG1291@2|Bacteria,3J0KF@40117|Nitrospirae	40117|Nitrospirae	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
LZS2_k127_1264001_6	330214.NIDE2349	1.235e-39	154.0	COG3143@1|root,COG3143@2|Bacteria,3J1AW@40117|Nitrospirae	40117|Nitrospirae	NT	Chemotaxis phosphatase, CheZ	-	-	-	ko:K03414	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheZ
LZS2_k127_1264001_4	330214.NIDE2348	5.013e-60	209.0	COG0745@1|root,COG0745@2|Bacteria,3J1FT@40117|Nitrospirae	40117|Nitrospirae	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
LZS2_k127_1264001_8	330214.NIDE2346	3.972e-27	112.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
LZS2_k127_1264001_1	330214.NIDE2345	1.759e-119	390.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	ylxH-3	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
LZS2_k127_1264001_9	207559.Dde_1834	4.236e-25	118.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WIJ8@28221|Deltaproteobacteria,2M82Q@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
LZS2_k127_1264001_7	330214.NIDE2342	8.057e-38	147.0	COG1516@1|root,COG1516@2|Bacteria,3J1A2@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
LZS2_k127_1264001_0	330214.NIDE2341	1.617e-146	477.0	COG1345@1|root,COG1345@2|Bacteria,3J0S1@40117|Nitrospirae	40117|Nitrospirae	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	-	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
LZS2_k127_1264001_10	330214.NIDE2340	2.437e-21	97.0	COG1334@1|root,COG1334@2|Bacteria	2|Bacteria	N	flagellar protein FlaG	flaG	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
LZS2_k127_1264001_3	330214.NIDE2339	2.954e-73	251.0	COG1344@1|root,COG1344@2|Bacteria,3J0UP@40117|Nitrospirae	40117|Nitrospirae	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
LZS2_k127_1268096_5	266117.Rxyl_0708	9.873e-25	109.0	2C3FA@1|root,32Y72@2|Bacteria,2GUDR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1268096_4	205918.Psyr_0769	3.871e-32	128.0	COG2323@1|root,COG2323@2|Bacteria,1RBQU@1224|Proteobacteria,1S3P7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
LZS2_k127_1268096_8	266117.Rxyl_0707	2.753e-07	52.0	COG2323@1|root,COG2323@2|Bacteria,2IIPT@201174|Actinobacteria,4CQP2@84995|Rubrobacteria	84995|Rubrobacteria	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
LZS2_k127_1268096_2	344747.PM8797T_04105	1.52e-47	177.0	arCOG06832@1|root,31H39@2|Bacteria,2J1NB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
LZS2_k127_1268096_6	522306.CAP2UW1_2075	1.079e-18	98.0	COG0457@1|root,COG3012@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3012@2|Bacteria,COG3903@2|Bacteria,1MWRF@1224|Proteobacteria,2VVW1@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_12,TPR_7
LZS2_k127_1268096_7	1218076.BAYB01000003_gene592	1.993e-12	68.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,2VW3H@28216|Betaproteobacteria	28216|Betaproteobacteria	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
LZS2_k127_1268096_1	448385.sce2438	1.295e-80	280.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42UHT@68525|delta/epsilon subdivisions,2WR0M@28221|Deltaproteobacteria,2YUP9@29|Myxococcales	28221|Deltaproteobacteria	C	oxidase, subunit	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
LZS2_k127_1268096_0	1379270.AUXF01000002_gene1773	3.489e-156	504.0	COG1271@1|root,COG1271@2|Bacteria,1ZUHF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
LZS2_k127_1268096_3	247490.KSU1_B0488	1.616e-32	128.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,2IXQK@203682|Planctomycetes	203682|Planctomycetes	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
LZS2_k127_1270224_0	330214.NIDE1277	1.907e-207	655.0	COG3225@1|root,COG3225@2|Bacteria	2|Bacteria	-	-	gldG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
LZS2_k127_1270224_1	330214.NIDE1278	1.424e-23	100.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	yxlG	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
LZS2_k127_1296568_24	330214.NIDE1340	4.066e-40	150.0	COG0203@1|root,COG0203@2|Bacteria,3J0TE@40117|Nitrospirae	40117|Nitrospirae	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
LZS2_k127_1296568_1	330214.NIDE1339	2.13e-178	563.0	COG0202@1|root,COG0202@2|Bacteria,3J0AR@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
LZS2_k127_1296568_5	330214.NIDE1338	6.512e-107	349.0	COG0522@1|root,COG0522@2|Bacteria,3J0IC@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
LZS2_k127_1296568_13	330214.NIDE1337	9.274e-71	240.0	COG0100@1|root,COG0100@2|Bacteria,3J0KE@40117|Nitrospirae	40117|Nitrospirae	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
LZS2_k127_1296568_16	330214.NIDE1336	1.7e-57	202.0	COG0099@1|root,COG0099@2|Bacteria,3J0Q5@40117|Nitrospirae	40117|Nitrospirae	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
LZS2_k127_1296568_31	717231.Flexsi_0487	1.915e-13	70.0	COG0257@1|root,COG0257@2|Bacteria,2GG6B@200930|Deferribacteres	200930|Deferribacteres	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
LZS2_k127_1296568_25	1033734.CAET01000080_gene3353	3.522e-35	134.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
LZS2_k127_1296568_4	330214.NIDE1333	2.469e-120	391.0	COG0024@1|root,COG0024@2|Bacteria,3J0GR@40117|Nitrospirae	40117|Nitrospirae	J	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
LZS2_k127_1296568_11	330214.NIDE1332	2.803e-82	279.0	COG0563@1|root,COG0563@2|Bacteria,3J0K3@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
LZS2_k127_1296568_0	330214.NIDE1331	3.474e-251	780.0	COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae	40117|Nitrospirae	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
LZS2_k127_1296568_15	330214.NIDE1330	9.822e-63	218.0	COG0200@1|root,COG0200@2|Bacteria,3J0PY@40117|Nitrospirae	40117|Nitrospirae	J	binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
LZS2_k127_1296568_29	330214.NIDE1329	7.795e-17	81.0	COG1841@1|root,COG1841@2|Bacteria	2|Bacteria	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
LZS2_k127_1296568_10	330214.NIDE1328	9.655e-83	278.0	COG0098@1|root,COG0098@2|Bacteria,3J0M3@40117|Nitrospirae	40117|Nitrospirae	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
LZS2_k127_1296568_20	330214.NIDE1327	3.116e-48	175.0	COG0256@1|root,COG0256@2|Bacteria,3J0QF@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
LZS2_k127_1296568_8	330214.NIDE1326	1.281e-88	294.0	COG0097@1|root,COG0097@2|Bacteria,3J0JB@40117|Nitrospirae	40117|Nitrospirae	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
LZS2_k127_1296568_19	330214.NIDE1325	4.545e-49	178.0	COG0096@1|root,COG0096@2|Bacteria,3J0SJ@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
LZS2_k127_1296568_28	330214.NIDE1324	2.081e-27	111.0	COG0199@1|root,COG0199@2|Bacteria,3J1C2@40117|Nitrospirae	40117|Nitrospirae	J	30S ribosomal protein S14	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
LZS2_k127_1296568_7	330214.NIDE1323	1.072e-99	328.0	COG0094@1|root,COG0094@2|Bacteria,3J0HN@40117|Nitrospirae	40117|Nitrospirae	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
LZS2_k127_1296568_22	330214.NIDE1322	3.118e-43	160.0	COG0198@1|root,COG0198@2|Bacteria,3J0VK@40117|Nitrospirae	40117|Nitrospirae	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
LZS2_k127_1296568_14	330214.NIDE1321	1.338e-69	237.0	COG0093@1|root,COG0093@2|Bacteria,3J0JD@40117|Nitrospirae	40117|Nitrospirae	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
LZS2_k127_1296568_26	330214.NIDE1320	4.844e-35	135.0	COG0186@1|root,COG0186@2|Bacteria,3J0TQ@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
LZS2_k127_1296568_30	330214.NIDE1319	9.444e-17	81.0	COG0255@1|root,COG0255@2|Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uL29 family	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
LZS2_k127_1296568_12	330214.NIDE1318	1.696e-75	254.0	COG0197@1|root,COG0197@2|Bacteria,3J0H7@40117|Nitrospirae	40117|Nitrospirae	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
LZS2_k127_1296568_3	330214.NIDE1317	3.741e-128	411.0	COG0092@1|root,COG0092@2|Bacteria,3J0AP@40117|Nitrospirae	40117|Nitrospirae	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
LZS2_k127_1296568_21	330214.NIDE1316	7.397e-48	174.0	COG0091@1|root,COG0091@2|Bacteria,3J0RZ@40117|Nitrospirae	40117|Nitrospirae	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
LZS2_k127_1296568_18	330214.NIDE1315	3.078e-53	190.0	COG0185@1|root,COG0185@2|Bacteria,3J0MU@40117|Nitrospirae	40117|Nitrospirae	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
LZS2_k127_1296568_2	330214.NIDE1314	6.816e-147	468.0	COG0090@1|root,COG0090@2|Bacteria,3J0BX@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
LZS2_k127_1296568_23	330214.NIDE1313	8.003e-43	158.0	COG0089@1|root,COG0089@2|Bacteria,3J0TP@40117|Nitrospirae	40117|Nitrospirae	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
LZS2_k127_1296568_9	330214.NIDE1312	6.48e-84	282.0	COG0088@1|root,COG0088@2|Bacteria,3J15W@40117|Nitrospirae	40117|Nitrospirae	J	Ribosomal protein L4/L1 family	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
LZS2_k127_1296568_6	330214.NIDE1311	4.693e-104	341.0	COG0087@1|root,COG0087@2|Bacteria,3J0HP@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
LZS2_k127_1296568_17	330214.NIDE1310	2.502e-54	191.0	COG0051@1|root,COG0051@2|Bacteria,3J0P3@40117|Nitrospirae	40117|Nitrospirae	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
LZS2_k127_1296568_27	330214.NIDE1294	9.053e-32	124.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
LZS2_k127_1297586_1	330214.NIDE4043	1.968e-65	228.0	COG1898@1|root,COG1898@2|Bacteria,3J0K0@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
LZS2_k127_1297586_5	330214.NIDE4045	2.018e-34	134.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS2_k127_1297586_4	330214.NIDE4047	3.157e-43	159.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
LZS2_k127_1297586_0	330214.NIDE4049	8.286e-80	270.0	2BXN6@1|root,2ZK04@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1297586_2	330214.NIDE4050	6.691e-52	192.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
LZS2_k127_1306982_4	1266925.JHVX01000003_gene547	4.263e-40	152.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,2WG0U@28216|Betaproteobacteria,372NF@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1306982_8	118163.Ple7327_3971	1.347e-07	57.0	2EJVP@1|root,33DKD@2|Bacteria,1G92U@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF5132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5132
LZS2_k127_1306982_1	671143.DAMO_1108	4.843e-185	585.0	COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
LZS2_k127_1306982_0	1123368.AUIS01000003_gene1785	0.0	1028.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2NCC6@225057|Acidithiobacillales	1236|Gammaproteobacteria	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
LZS2_k127_1306982_3	472759.Nhal_1388	1.168e-50	188.0	2BHJK@1|root,32BN1@2|Bacteria,1RJW9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1306982_7	880072.Desac_0202	4.793e-11	67.0	2EJVP@1|root,33DKD@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF5132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5132
LZS2_k127_1306982_9	500633.CLOHIR_01759	0.0001472	51.0	2A5D3@1|root,30U2T@2|Bacteria,1W16Q@1239|Firmicutes,24TST@186801|Clostridia,25RU6@186804|Peptostreptococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	HMA
LZS2_k127_1306982_6	880072.Desac_0204	3.428e-13	75.0	2DTG5@1|root,33K7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1306982_5	1120953.AUBH01000003_gene2104	8.032e-36	141.0	COG1943@1|root,COG1943@2|Bacteria,1N7RA@1224|Proteobacteria	1224|Proteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
LZS2_k127_1306982_2	395019.Bmul_5727	1.427e-132	432.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
LZS2_k127_1327296_5	1123368.AUIS01000005_gene413	1.41e-18	93.0	COG3652@1|root,COG3652@2|Bacteria,1N6QU@1224|Proteobacteria,1T0P2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4142
LZS2_k127_1327296_4	1227739.Hsw_4081	1.865e-20	96.0	COG0657@1|root,COG0657@2|Bacteria,4NFDH@976|Bacteroidetes,47NU7@768503|Cytophagia	976|Bacteroidetes	I	Alpha beta hydrolase fold-3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
LZS2_k127_1327296_3	251221.35211298	2.827e-46	177.0	COG5637@1|root,COG5637@2|Bacteria,1G2FS@1117|Cyanobacteria	1117|Cyanobacteria	S	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
LZS2_k127_1327296_2	977880.RALTA_B1361	1.611e-54	198.0	2C4KU@1|root,32RE6@2|Bacteria,1RBD1@1224|Proteobacteria,2VTSN@28216|Betaproteobacteria,1K9CW@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1327296_1	330214.NIDE3803	1.734e-74	261.0	COG3647@1|root,COG3647@2|Bacteria	2|Bacteria	S	Membrane	yjdF	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
LZS2_k127_1327296_0	330214.NIDE3804	7.656e-89	297.0	COG3647@1|root,COG3647@2|Bacteria	2|Bacteria	S	Membrane	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
LZS2_k127_1329416_1	330214.NIDE1916	1.978e-115	375.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,DNA_pol_B_exo2,RNase_H_2
LZS2_k127_1329416_2	330214.NIDE1915	5.045e-52	187.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	mutY	-	3.6.1.55	ko:K03574,ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX,NUDIX_4
LZS2_k127_1329416_0	330214.NIDE1914	1.272e-126	407.0	COG1194@1|root,COG1194@2|Bacteria,3J160@40117|Nitrospirae	40117|Nitrospirae	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
LZS2_k127_1390125_0	330214.NIDE1868	9.228e-264	820.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
LZS2_k127_1390125_1	330214.NIDE3387	1.321e-150	489.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_1390125_3	330214.NIDE0543	8.38e-48	192.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0543|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1390125_4	671143.DAMO_2592	7.353e-39	157.0	COG2984@1|root,COG2984@2|Bacteria,2NPCT@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
LZS2_k127_1390125_2	330214.NIDE0547	9.103e-76	259.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
LZS2_k127_1390225_0	984262.SGRA_3214	1.216e-95	340.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,4NMVU@976|Bacteroidetes	976|Bacteroidetes	KT	Histidine kinase-like ATPase domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c_2,SpoIIE
LZS2_k127_1390225_2	221027.JO40_08690	0.0006253	47.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
LZS2_k127_1398798_0	330214.NIDE2247	0.0	1264.0	COG0587@1|root,COG0587@2|Bacteria,3J0FE@40117|Nitrospirae	2|Bacteria	L	DNA-directed DNA polymerase	dnaE-2	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
LZS2_k127_1398798_14	330214.NIDE2248	4.468e-89	307.0	COG0389@1|root,COG0389@2|Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
LZS2_k127_1398798_23	330214.NIDE0789	4.04e-35	138.0	COG0360@1|root,COG0360@2|Bacteria,3J0VS@40117|Nitrospirae	40117|Nitrospirae	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
LZS2_k127_1398798_17	330214.NIDE0790	7.79e-64	221.0	COG0629@1|root,COG0629@2|Bacteria,3J0NB@40117|Nitrospirae	40117|Nitrospirae	L	Single-strand binding protein family	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
LZS2_k127_1398798_25	1297742.A176_02064	1.587e-21	96.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
LZS2_k127_1398798_21	330214.NIDE0792	1.445e-42	164.0	COG1399@1|root,COG1399@2|Bacteria,3J0UQ@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
LZS2_k127_1398798_26	289376.THEYE_A1479	4.637e-16	79.0	COG0333@1|root,COG0333@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
LZS2_k127_1398798_3	330214.NIDE0794	9.135e-169	539.0	COG0416@1|root,COG0416@2|Bacteria,3J0DY@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
LZS2_k127_1398798_4	330214.NIDE0795	1.236e-162	516.0	COG0332@1|root,COG0332@2|Bacteria,3J0FW@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
LZS2_k127_1398798_7	330214.NIDE0796	2.106e-145	466.0	COG0331@1|root,COG0331@2|Bacteria,3J0IX@40117|Nitrospirae	40117|Nitrospirae	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
LZS2_k127_1398798_9	330214.NIDE0797	3.784e-123	398.0	COG1028@1|root,COG1028@2|Bacteria,3J0J6@40117|Nitrospirae	40117|Nitrospirae	IQ	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
LZS2_k127_1398798_24	330214.NIDE0798	4.198e-33	130.0	COG0236@1|root,COG0236@2|Bacteria,3J0RX@40117|Nitrospirae	40117|Nitrospirae	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
LZS2_k127_1398798_1	330214.NIDE0799	7.37e-241	748.0	COG0304@1|root,COG0304@2|Bacteria,3J0DH@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
LZS2_k127_1398798_16	330214.NIDE0800	1.893e-78	269.0	COG0571@1|root,COG0571@2|Bacteria,3J119@40117|Nitrospirae	40117|Nitrospirae	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	-	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
LZS2_k127_1398798_15	330214.NIDE0801	1.305e-80	273.0	COG0652@1|root,COG0652@2|Bacteria,3J18H@40117|Nitrospirae	40117|Nitrospirae	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
LZS2_k127_1398798_13	330214.NIDE0808	7.44e-105	344.0	2EGFY@1|root,33A7X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1398798_11	330214.NIDE0809	8.368e-110	364.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
LZS2_k127_1398798_6	330214.NIDE0810	8.354e-155	492.0	COG0190@1|root,COG0190@2|Bacteria,3J0FT@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
LZS2_k127_1398798_5	330214.NIDE0811	4.152e-158	501.0	COG0685@1|root,COG0685@2|Bacteria,3J0I8@40117|Nitrospirae	40117|Nitrospirae	C	Methylenetetrahydrofolate reductase	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR
LZS2_k127_1398798_10	330214.NIDE0812	4.335e-123	398.0	COG0413@1|root,COG0413@2|Bacteria,3J0GX@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
LZS2_k127_1398798_20	330214.NIDE0813	3.416e-44	166.0	COG1547@1|root,COG1547@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
LZS2_k127_1398798_12	330214.NIDE0814	3.892e-106	351.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074	Metallophos
LZS2_k127_1398798_19	330214.NIDE0820	4.668e-62	215.0	COG0780@1|root,COG0780@2|Bacteria,3J0R4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
LZS2_k127_1398798_2	330214.NIDE0823	2.245e-187	586.0	COG1013@1|root,COG1013@2|Bacteria,3J10F@40117|Nitrospirae	2|Bacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	forB2	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
LZS2_k127_1398798_8	330214.NIDE0824	1.641e-136	436.0	COG1014@1|root,COG1014@2|Bacteria,3J0YE@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
LZS2_k127_1398798_18	330214.NIDE0825	2.92e-63	217.0	COG1144@1|root,COG1144@2|Bacteria,3J1A9@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_140486_1	179408.Osc7112_6220	9.408e-17	92.0	COG0457@1|root,COG0457@2|Bacteria,1G5VM@1117|Cyanobacteria,1HE7X@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
LZS2_k127_140486_0	316067.Geob_1040	3.224e-27	119.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	Chromosomal replication initiator, DnaA	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Bac_DnaA_C,Y1_Tnp
LZS2_k127_1409674_0	330214.NIDE0841	1.409e-172	543.0	COG0074@1|root,COG0074@2|Bacteria,3J0WZ@40117|Nitrospirae	40117|Nitrospirae	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
LZS2_k127_1429564_0	330214.NIDE4030	0.0	1127.0	COG5009@1|root,COG5009@2|Bacteria,3J0BH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding protein OB-like domain	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
LZS2_k127_1429564_11	330214.NIDE4029	6.869e-33	129.0	COG2975@1|root,COG2975@2|Bacteria,3J1CR@40117|Nitrospirae	40117|Nitrospirae	S	Iron-sulphur cluster assembly	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
LZS2_k127_1429564_1	330214.NIDE4028	3.01e-315	974.0	COG0443@1|root,COG0443@2|Bacteria,3J0YD@40117|Nitrospirae	40117|Nitrospirae	O	Hsp70 protein	hscA	-	-	ko:K04043,ko:K04044	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33,1.A.33.1	-	-	HSP70
LZS2_k127_1429564_5	330214.NIDE4027	3.502e-82	280.0	COG1076@1|root,COG1076@2|Bacteria,3J1CS@40117|Nitrospirae	40117|Nitrospirae	O	DnaJ molecular chaperone homology domain	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	-
LZS2_k127_1429564_10	330214.NIDE4026	2.406e-62	215.0	COG0316@1|root,COG0316@2|Bacteria,3J17Y@40117|Nitrospirae	40117|Nitrospirae	S	Iron-sulphur cluster biosynthesis	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
LZS2_k127_1429564_7	330214.NIDE4025	6.54e-72	244.0	COG0822@1|root,COG0822@2|Bacteria,3J123@40117|Nitrospirae	40117|Nitrospirae	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
LZS2_k127_1429564_3	330214.NIDE4024	4.562e-227	709.0	COG1104@1|root,COG1104@2|Bacteria,3J0AX@40117|Nitrospirae	40117|Nitrospirae	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
LZS2_k127_1429564_6	330214.NIDE4023	7.364e-78	263.0	COG1959@1|root,COG1959@2|Bacteria,3J18M@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
LZS2_k127_1429564_8	330214.NIDE4022	4.904e-69	237.0	COG0633@1|root,COG0633@2|Bacteria,3J1AM@40117|Nitrospirae	40117|Nitrospirae	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
LZS2_k127_1429564_9	330214.NIDE4021	5.383e-67	235.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	poxF	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
LZS2_k127_1429564_2	330214.NIDE4019	6.704e-264	817.0	COG0008@1|root,COG0008@2|Bacteria,3J0CJ@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
LZS2_k127_1429564_4	159087.Daro_2223	1.095e-204	642.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2VMP0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Pfam Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
LZS2_k127_1429564_12	330214.NIDE3498	1.623e-19	91.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat
LZS2_k127_1456002_4	330214.NIDE1147	4.431e-13	70.0	292MF@1|root,2ZQ5C@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
LZS2_k127_1456002_0	330214.NIDE1146	2.481e-267	830.0	COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
LZS2_k127_1456002_1	330214.NIDE1145	7.602e-89	302.0	COG0398@1|root,COG0398@2|Bacteria	2|Bacteria	M	Pfam SNARE associated Golgi protein	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,SNARE_assoc
LZS2_k127_1456002_3	330214.NIDE1143	5.285e-17	85.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
LZS2_k127_1463031_1	1122135.KB893171_gene2123	2.303e-60	211.0	COG3045@1|root,COG3045@2|Bacteria,1RDMP@1224|Proteobacteria,2U72F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM CreA family protein	creA	-	-	ko:K05805	-	-	-	-	ko00000	-	-	-	CreA
LZS2_k127_1463031_4	331869.BAL199_20949	9.153e-28	118.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,4BSDR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
LZS2_k127_1463031_3	1266925.JHVX01000002_gene1051	3.225e-48	174.0	COG1733@1|root,COG1733@2|Bacteria,1N414@1224|Proteobacteria,2VV92@28216|Betaproteobacteria,373CB@32003|Nitrosomonadales	28216|Betaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
LZS2_k127_1463031_0	857087.Metme_3692	2.594e-74	253.0	COG1942@1|root,COG1942@2|Bacteria,1N4WZ@1224|Proteobacteria,1SG4Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative oxalocrotonate tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_3
LZS2_k127_1463031_5	926569.ANT_01930	4.19e-23	104.0	2BECK@1|root,3283Q@2|Bacteria	2|Bacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
LZS2_k127_1463031_2	1123261.AXDW01000010_gene340	4.005e-50	179.0	2BECK@1|root,3283Q@2|Bacteria,1RKSC@1224|Proteobacteria,1T14S@1236|Gammaproteobacteria,1X9RS@135614|Xanthomonadales	135614|Xanthomonadales	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
LZS2_k127_1470402_2	1283287.KB822576_gene3898	9.004e-12	76.0	COG1748@1|root,COG1748@2|Bacteria,2GMQ1@201174|Actinobacteria,4DPGK@85009|Propionibacteriales	201174|Actinobacteria	E	Saccharopine dehydrogenase C-terminal domain	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
LZS2_k127_1470402_0	330214.NIDE3247	8.37e-72	250.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
LZS2_k127_1470402_1	1267535.KB906767_gene5221	2.546e-44	169.0	COG1352@1|root,COG2201@1|root,COG4585@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	cheB	-	2.1.1.80,3.1.1.61,3.5.1.44	ko:K03412,ko:K03413,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,HisKA_3,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_1480692_0	234267.Acid_2881	2.112e-50	187.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_1480692_3	1304885.AUEY01000045_gene250	2.432e-11	71.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WJSJ@28221|Deltaproteobacteria,2MN6H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
LZS2_k127_1480692_4	639030.JHVA01000001_gene2746	3.153e-05	47.0	COG2208@1|root,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
LZS2_k127_1491525_4	1267534.KB906757_gene965	4.978e-13	69.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
LZS2_k127_1491525_0	589924.Ferp_2545	7.335e-87	304.0	COG0006@1|root,arCOG01000@2157|Archaea,2XWEI@28890|Euryarchaeota	28890|Euryarchaeota	E	Creatinase/Prolidase N-terminal domain	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
LZS2_k127_1491525_1	595460.RRSWK_03946	6.742e-77	266.0	COG2846@1|root,COG2846@2|Bacteria	2|Bacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	ytfE	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564	-	ko:K07322	-	-	-	-	ko00000	-	-	iECED1_1282.ECED1_5068,iECH74115_1262.ECH74115_5726,iECSP_1301.ECSP_5311,iECs_1301.ECs5187,iG2583_1286.G2583_5039,iZ_1308.Z5820	Hemerythrin,ScdA_N
LZS2_k127_1491525_2	909663.KI867150_gene2870	3.805e-50	186.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,2MRR6@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1491525_3	290397.Adeh_0448	1.332e-17	88.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,42NBZ@68525|delta/epsilon subdivisions,2WJ39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
LZS2_k127_151532_3	330214.NIDE1937	4.591e-66	228.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
LZS2_k127_151532_1	330214.NIDE1934	7.742e-141	459.0	COG0477@1|root,COG2814@2|Bacteria,3J0ZP@40117|Nitrospirae	40117|Nitrospirae	EGP	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
LZS2_k127_151532_0	330214.NIDE1920	2.707e-162	522.0	COG0621@1|root,COG0621@2|Bacteria,3J112@40117|Nitrospirae	40117|Nitrospirae	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
LZS2_k127_151532_2	330214.NIDE1919	2.192e-137	444.0	COG0621@1|root,COG0621@2|Bacteria,3J0GE@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
LZS2_k127_1530500_14	330214.NIDE0767	7.456e-09	57.0	COG0206@1|root,COG0206@2|Bacteria,3J0D4@40117|Nitrospirae	40117|Nitrospirae	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
LZS2_k127_1530500_2	330214.NIDE0766	2.041e-213	668.0	COG0849@1|root,COG0849@2|Bacteria,3J0Q3@40117|Nitrospirae	40117|Nitrospirae	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
LZS2_k127_1530500_12	330214.NIDE0765	1.971e-45	176.0	COG1589@1|root,COG1589@2|Bacteria	2|Bacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
LZS2_k127_1530500_9	330214.NIDE0764	1.334e-131	427.0	COG1181@1|root,COG1181@2|Bacteria,3J0JM@40117|Nitrospirae	40117|Nitrospirae	F	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
LZS2_k127_1530500_10	330214.NIDE0763	1.454e-124	406.0	COG0812@1|root,COG0812@2|Bacteria,3J0Q1@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
LZS2_k127_1530500_0	330214.NIDE0762	1.632e-247	769.0	COG0773@1|root,COG0773@2|Bacteria,3J0D5@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
LZS2_k127_1530500_8	330214.NIDE0761	1.016e-133	456.0	COG0707@1|root,COG0707@2|Bacteria,3J0JS@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
LZS2_k127_1530500_7	330214.NIDE0760	4.827e-155	498.0	COG0772@1|root,COG0772@2|Bacteria,3J0M8@40117|Nitrospirae	40117|Nitrospirae	D	Cell cycle protein	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
LZS2_k127_1530500_5	330214.NIDE0759	1.082e-186	593.0	COG0771@1|root,COG0771@2|Bacteria,3J0HT@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
LZS2_k127_1530500_4	330214.NIDE0758	3.87e-196	615.0	COG0472@1|root,COG0472@2|Bacteria,3J0C4@40117|Nitrospirae	40117|Nitrospirae	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
LZS2_k127_1530500_6	330214.NIDE0757	2.906e-181	578.0	COG0770@1|root,COG0770@2|Bacteria,3J0PW@40117|Nitrospirae	40117|Nitrospirae	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
LZS2_k127_1530500_3	330214.NIDE0756	3.035e-202	640.0	COG0769@1|root,COG0769@2|Bacteria,3J0DS@40117|Nitrospirae	40117|Nitrospirae	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
LZS2_k127_1530500_1	330214.NIDE0755	3.795e-233	734.0	COG0768@1|root,COG0768@2|Bacteria,3J0FH@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
LZS2_k127_1530500_13	330214.NIDE0754	2.184e-23	104.0	2DT1T@1|root,33IAD@2|Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	FtsL
LZS2_k127_1530500_11	330214.NIDE0753	2.13e-94	316.0	COG0275@1|root,COG0275@2|Bacteria,3J0NU@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	mraW	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
LZS2_k127_155522_4	330214.NIDE1186	1.985e-34	133.0	COG0249@1|root,COG0249@2|Bacteria	2|Bacteria	L	mismatched DNA binding	mutS1	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_III,MutS_V
LZS2_k127_155522_0	330214.NIDE1185	0.0	1609.0	COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,3J17I@40117|Nitrospirae	40117|Nitrospirae	I	Phosphate acyltransferases	-	-	2.3.1.40,6.2.1.20,6.2.1.3	ko:K01897,ko:K05939	ko00061,ko00071,ko00564,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00564,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280,R01406,R04864	RC00004,RC00014,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Acyltransferase
LZS2_k127_155522_1	330214.NIDE1184	3.976e-167	531.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
LZS2_k127_155522_2	330214.NIDE1183	2.963e-77	261.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_155522_3	330214.NIDE1182	2.888e-55	211.0	2E7Z1@1|root,332DD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_155522_5	330214.NIDE1081	1.709e-20	92.0	COG1196@1|root,COG1555@1|root,COG1196@2|Bacteria,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
LZS2_k127_156972_2	330214.NIDE0302	4.66e-211	663.0	COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
LZS2_k127_156972_5	665571.STHERM_c16570	1.089e-98	330.0	COG0788@1|root,COG0788@2|Bacteria,2J7GR@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
LZS2_k127_156972_1	330214.NIDE0304	1.13e-218	686.0	COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3J11K@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
LZS2_k127_156972_4	330214.NIDE0305	9.117e-120	389.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE0305|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_156972_0	330214.NIDE0312	0.0	1513.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,3J0XT@40117|Nitrospirae	40117|Nitrospirae	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	-
LZS2_k127_156972_3	342610.Patl_1687	1.238e-139	456.0	COG0520@1|root,COG0520@2|Bacteria,1R4SM@1224|Proteobacteria,1RQR6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Class V aminotransferase	-	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
LZS2_k127_156972_7	1267535.KB906767_gene2617	1.585e-34	137.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS2_k127_156972_11	706587.Desti_0629	1.217e-17	84.0	COG5450@1|root,COG5450@2|Bacteria,1Q2TR@1224|Proteobacteria,42W8I@68525|delta/epsilon subdivisions,2WRTI@28221|Deltaproteobacteria,2MS5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
LZS2_k127_156972_6	177437.HRM2_34090	6.022e-61	225.0	COG1262@1|root,COG4928@1|root,COG1262@2|Bacteria,COG4928@2|Bacteria,1Q99I@1224|Proteobacteria,4349K@68525|delta/epsilon subdivisions,2X1U0@28221|Deltaproteobacteria,2MPDU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_156972_10	1463885.KL578392_gene2399	2.847e-19	100.0	COG2815@1|root,COG2815@2|Bacteria,2ID52@201174|Actinobacteria	201174|Actinobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
LZS2_k127_156972_8	633131.TR2A62_0064	7.449e-28	120.0	COG0790@1|root,COG0790@2|Bacteria,1N6ZB@1224|Proteobacteria,2UJ1A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Sel1
LZS2_k127_156972_12	880072.Desac_0884	6.245e-06	49.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
LZS2_k127_156972_9	626887.J057_08051	6.428e-26	108.0	COG4728@1|root,COG4728@2|Bacteria,1N6NP@1224|Proteobacteria,1SCKQ@1236|Gammaproteobacteria,468GN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1653
LZS2_k127_1599227_17	330214.NIDE0372	3.124e-84	279.0	COG0055@1|root,COG0055@2|Bacteria,3J0BN@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
LZS2_k127_1599227_21	330214.NIDE0373	8.602e-62	217.0	COG0355@1|root,COG0355@2|Bacteria,3J0SS@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
LZS2_k127_1599227_3	330214.NIDE0379	2.027e-142	458.0	COG0564@1|root,COG0564@2|Bacteria,3J0HF@40117|Nitrospirae	40117|Nitrospirae	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
LZS2_k127_1599227_22	330214.NIDE0382	2.356e-55	196.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
LZS2_k127_1599227_28	330214.NIDE3647	3.917e-29	125.0	COG3047@1|root,COG3047@2|Bacteria	2|Bacteria	-	-	ompW	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	PagL
LZS2_k127_1599227_11	330214.NIDE0383	4.341e-123	399.0	COG1108@1|root,COG1108@2|Bacteria,3J1EQ@40117|Nitrospirae	40117|Nitrospirae	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
LZS2_k127_1599227_9	330214.NIDE0384	1.787e-131	423.0	COG1121@1|root,COG1121@2|Bacteria,3J15M@40117|Nitrospirae	40117|Nitrospirae	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09817,ko:K09820	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
LZS2_k127_1599227_15	330214.NIDE0385	1.181e-103	346.0	COG0803@1|root,COG0803@2|Bacteria,3J1E3@40117|Nitrospirae	40117|Nitrospirae	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
LZS2_k127_1599227_1	330214.NIDE0386	2.195e-148	480.0	COG2377@1|root,COG2377@2|Bacteria,3J126@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
LZS2_k127_1599227_23	330214.NIDE0388	1.408e-52	190.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	FecR,TPR_16,TPR_6,WG_beta_rep
LZS2_k127_1599227_12	330214.NIDE0389	6.803e-117	381.0	COG4677@1|root,COG4677@2|Bacteria	2|Bacteria	G	pectinesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Lipase_GDSL_2,NosD,Pectate_lyase_3
LZS2_k127_1599227_10	330214.NIDE0390	3.765e-126	411.0	COG2199@1|root,COG3706@2|Bacteria,3J17A@40117|Nitrospirae	40117|Nitrospirae	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
LZS2_k127_1599227_19	330214.NIDE4037	3.389e-73	261.0	COG1511@1|root,COG1511@2|Bacteria	2|Bacteria	Q	domain protein	-	-	-	ko:K02004,ko:K06994	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS2_k127_1599227_24	330214.NIDE4036	1.322e-49	184.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K02487,ko:K12543	ko02020,map02020	M00330,M00507	-	-	ko00000,ko00001,ko00002,ko02000,ko02022,ko02035,ko02044	1.B.17,3.A.1.109.4	-	-	OEP,OmpA,TSP_3
LZS2_k127_1599227_18	330214.NIDE0538	1.401e-79	275.0	COG0030@1|root,COG0030@2|Bacteria,3J0R6@40117|Nitrospirae	40117|Nitrospirae	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
LZS2_k127_1599227_5	330214.NIDE0536	7.438e-136	442.0	COG1995@1|root,COG1995@2|Bacteria,3J0GF@40117|Nitrospirae	40117|Nitrospirae	C	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
LZS2_k127_1599227_7	330214.NIDE0535	4.466e-134	439.0	COG0530@1|root,COG0530@2|Bacteria,3J0V1@40117|Nitrospirae	40117|Nitrospirae	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
LZS2_k127_1599227_2	330214.NIDE0534	5.792e-144	467.0	COG1641@1|root,COG1641@2|Bacteria	2|Bacteria	H	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
LZS2_k127_1599227_14	330214.NIDE0532	5.943e-105	346.0	COG1691@1|root,COG1691@2|Bacteria	2|Bacteria	C	(AIR) carboxylase	cpmA	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
LZS2_k127_1599227_6	330214.NIDE0531	3.819e-134	435.0	COG0240@1|root,COG0240@2|Bacteria,3J0GP@40117|Nitrospirae	40117|Nitrospirae	I	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
LZS2_k127_1599227_32	880072.Desac_1404	8.715e-08	63.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K10936,ko:K16079	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.4.2.1	-	-	OMP_b-brl
LZS2_k127_1599227_8	330214.NIDE0529	2.458e-132	428.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Amidinotransf,Saccharop_dh_N
LZS2_k127_1599227_0	330214.NIDE0528	7.73e-194	613.0	COG1915@1|root,COG1915@2|Bacteria	2|Bacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
LZS2_k127_1599227_4	330214.NIDE0527	1.746e-140	456.0	COG0585@1|root,COG0585@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	truD	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
LZS2_k127_1599227_13	330214.NIDE0525	9.98e-112	369.0	COG1408@1|root,COG1408@2|Bacteria,3J0SB@40117|Nitrospirae	40117|Nitrospirae	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
LZS2_k127_1599227_20	330214.NIDE0524	8.004e-66	231.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	4.4.1.31	ko:K02632	ko00196,map00196	-	-	-	ko00000,ko00001,ko00194,ko01000	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_1599227_16	330214.NIDE0522	4.78e-86	289.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Lactamase_B_2
LZS2_k127_1600292_2	330214.NIDE2482	2.953e-43	160.0	COG2146@1|root,COG2146@2|Bacteria,3J1E7@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
LZS2_k127_1600292_0	330214.NIDE2481	4.549e-135	436.0	COG0489@1|root,COG0489@2|Bacteria,3J0Z6@40117|Nitrospirae	40117|Nitrospirae	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
LZS2_k127_1600292_1	330214.NIDE2475	9.653e-67	231.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512,iYO844.BSU37780	Aldedh,Pro_dh
LZS2_k127_1605644_17	857087.Metme_0345	8.386e-25	119.0	COG1262@1|root,COG1262@2|Bacteria,1QY0H@1224|Proteobacteria	1224|Proteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
LZS2_k127_1605644_10	1254432.SCE1572_47310	4.519e-102	343.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
LZS2_k127_1605644_14	351160.RCIX2417	6.553e-47	177.0	COG0584@1|root,arCOG00701@2157|Archaea,2XXRI@28890|Euryarchaeota,2NB63@224756|Methanomicrobia	224756|Methanomicrobia	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
LZS2_k127_1605644_18	100226.SCO3461	2.958e-12	74.0	2FA7T@1|root,342GG@2|Bacteria,2IMMX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MauE
LZS2_k127_1605644_6	330214.NIDE0147	1.91e-133	430.0	COG2326@1|root,COG2326@2|Bacteria,3J111@40117|Nitrospirae	40117|Nitrospirae	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
LZS2_k127_1605644_12	330214.NIDE4035	2.023e-61	225.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_1605644_7	330214.NIDE4337	1.363e-119	389.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
LZS2_k127_1605644_3	330214.NIDE0057	3.696e-145	467.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
LZS2_k127_1605644_11	1380391.JIAS01000014_gene2278	2.676e-72	247.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2U5Q5@28211|Alphaproteobacteria,2JS6E@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
LZS2_k127_1605644_16	330214.NIDE0619	4.484e-31	123.0	COG2826@1|root,COG2826@2|Bacteria	2|Bacteria	L	transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
LZS2_k127_1605644_5	330214.NIDE0055	2.959e-143	460.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
LZS2_k127_1605644_4	330214.NIDE4335	9.088e-144	459.0	COG0708@1|root,COG0708@2|Bacteria,3J13K@40117|Nitrospirae	40117|Nitrospirae	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
LZS2_k127_1605644_2	330214.NIDE3615	1.194e-158	511.0	COG2081@1|root,COG2081@2|Bacteria,3J12U@40117|Nitrospirae	40117|Nitrospirae	S	HI0933-like protein	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
LZS2_k127_1605644_1	330214.NIDE3195	3.939e-166	528.0	COG0438@1|root,COG0438@2|Bacteria,3J120@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS2_k127_1605644_8	330214.NIDE4234	6.533e-112	365.0	COG0284@1|root,COG0284@2|Bacteria,3J0SC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
LZS2_k127_1605644_19	388401.RB2150_11746	2.508e-10	64.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,3ZHNR@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
LZS2_k127_1605644_9	330214.NIDE4236	7.422e-112	372.0	COG1466@1|root,COG1466@2|Bacteria,3J1EC@40117|Nitrospirae	40117|Nitrospirae	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
LZS2_k127_1605644_0	330214.NIDE4238	0.0	1372.0	COG0495@1|root,COG0495@2|Bacteria,3J0F8@40117|Nitrospirae	40117|Nitrospirae	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
LZS2_k127_1671342_0	756272.Plabr_3346	2.145e-53	191.0	COG0733@1|root,COG0733@2|Bacteria,2J29X@203682|Planctomycetes	203682|Planctomycetes	S	Sodium:neurotransmitter symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SNF
LZS2_k127_1671342_1	1121405.dsmv_2346	4.659e-26	115.0	COG3945@1|root,COG3945@2|Bacteria,1QR7V@1224|Proteobacteria,4379K@68525|delta/epsilon subdivisions,2X9XT@28221|Deltaproteobacteria,2MNU4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
LZS2_k127_1671342_2	204669.Acid345_1548	0.0001129	53.0	COG3585@1|root,COG3585@2|Bacteria,3Y50T@57723|Acidobacteria,2JJMJ@204432|Acidobacteriia	204432|Acidobacteriia	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,TOBE
LZS2_k127_167402_6	373994.Riv7116_0371	2.117e-131	426.0	COG0500@1|root,COG0500@2|Bacteria,1GHCT@1117|Cyanobacteria,1HQWE@1161|Nostocales	1117|Cyanobacteria	H	Putative zinc binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
LZS2_k127_167402_2	330214.NIDE2887	3.171e-222	696.0	COG1004@1|root,COG1004@2|Bacteria,3J0EJ@40117|Nitrospirae	2|Bacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
LZS2_k127_167402_3	330214.NIDE2888	2.164e-195	614.0	COG0451@1|root,COG0451@2|Bacteria,3J0BW@40117|Nitrospirae	2|Bacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
LZS2_k127_167402_7	330214.NIDE2890	5.435e-123	398.0	COG1208@1|root,COG1208@2|Bacteria,3J0K1@40117|Nitrospirae	40117|Nitrospirae	JM	Nucleotidyl transferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
LZS2_k127_167402_13	909663.KI867150_gene2493	1.3e-26	115.0	COG0250@1|root,COG0250@2|Bacteria,1Q2A0@1224|Proteobacteria,437WT@68525|delta/epsilon subdivisions,2X36G@28221|Deltaproteobacteria,2MSA8@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
LZS2_k127_167402_9	330214.NIDE2901	3.082e-95	315.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
LZS2_k127_167402_4	330214.NIDE2906	3.465e-167	539.0	COG0297@1|root,COG0297@2|Bacteria,3J0DJ@40117|Nitrospirae	40117|Nitrospirae	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
LZS2_k127_167402_10	330214.NIDE2908	6.8e-63	217.0	COG3536@1|root,COG3536@2|Bacteria,3J1AV@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
LZS2_k127_167402_8	330214.NIDE2909	1.344e-96	322.0	COG1381@1|root,COG1381@2|Bacteria,3J0S8@40117|Nitrospirae	40117|Nitrospirae	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
LZS2_k127_167402_1	330214.NIDE2910	6.201e-223	699.0	COG2239@1|root,COG2239@2|Bacteria	2|Bacteria	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
LZS2_k127_167402_5	330214.NIDE2911	7.751e-135	436.0	COG1159@1|root,COG1159@2|Bacteria,3J0IB@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
LZS2_k127_167402_14	330214.NIDE2912	1.846e-23	104.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	ftsB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
LZS2_k127_167402_0	330214.NIDE2913	6.141e-241	748.0	COG0148@1|root,COG0148@2|Bacteria,3J0DB@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
LZS2_k127_1722431_2	330214.NIDE3169	4.431e-82	276.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
LZS2_k127_1722431_0	330214.NIDE3195	9.598e-167	531.0	COG0438@1|root,COG0438@2|Bacteria,3J120@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS2_k127_1733310_1	330214.NIDE1284	2.4e-48	182.0	COG0797@1|root,COG0797@2|Bacteria	2|Bacteria	M	peptidoglycan binding	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,LysM
LZS2_k127_1733310_0	330214.NIDE1286	4.419e-110	362.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_1740323_4	330214.NIDE2336	1.068e-114	379.0	COG4641@1|root,COG4641@2|Bacteria,3J0ZZ@40117|Nitrospirae	40117|Nitrospirae	S	DUF based on E. rectale Gene description (DUF3880)	-	-	-	ko:K06320	-	-	-	-	ko00000	-	-	-	DUF3880,Glyco_trans_1_2
LZS2_k127_1740323_6	330214.NIDE2335	1.325e-83	293.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
LZS2_k127_1740323_1	330214.NIDE2334	7.222e-170	588.0	COG0438@1|root,COG1215@1|root,COG1216@1|root,COG2227@1|root,COG3118@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	celD	-	-	ko:K02453,ko:K07280,ko:K20444,ko:K20543	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000,ko02044	1.B.55.3,3.A.15,4.D.1.3	GT2,GT4	-	BCSC_C,Glyco_transf_41,Glycos_transf_2,TPR_16,TPR_19,TPR_8
LZS2_k127_1740323_7	446470.Snas_0053	5.614e-67	262.0	COG4122@1|root,COG4122@2|Bacteria,2IEVU@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
LZS2_k127_1740323_5	443143.GM18_4173	5.165e-90	338.0	COG1216@1|root,COG1442@1|root,COG1216@2|Bacteria,COG1442@2|Bacteria,1RGUZ@1224|Proteobacteria,42SZI@68525|delta/epsilon subdivisions,2X7M1@28221|Deltaproteobacteria,43V61@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS2_k127_1740323_3	443143.GM18_4172	3.186e-130	426.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,43T8C@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
LZS2_k127_1740323_2	398767.Glov_3365	1.102e-159	509.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42Q4Y@68525|delta/epsilon subdivisions,2WKZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
LZS2_k127_1740323_0	398767.Glov_3363	6.854e-189	624.0	COG0500@1|root,COG1032@1|root,COG4122@1|root,COG4641@1|root,COG1032@2|Bacteria,COG2226@2|Bacteria,COG4122@2|Bacteria,COG4641@2|Bacteria,1R62R@1224|Proteobacteria,42YHA@68525|delta/epsilon subdivisions,2WU5S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Methyltransf_11
LZS2_k127_1740323_9	345341.KUTG_05001	7.099e-06	60.0	COG4122@1|root,COG4122@2|Bacteria,2IP3G@201174|Actinobacteria,4E171@85010|Pseudonocardiales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
LZS2_k127_1740323_8	330214.NIDE2325	2.417e-31	127.0	COG5581@1|root,COG5581@2|Bacteria	2|Bacteria	M	regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
LZS2_k127_1746004_1	330214.NIDE2305	1.707e-26	109.0	COG1377@1|root,COG1377@2|Bacteria,3J0J3@40117|Nitrospirae	40117|Nitrospirae	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
LZS2_k127_1746004_0	330214.NIDE2306	2.5e-323	1001.0	COG1298@1|root,COG1298@2|Bacteria,3J0B1@40117|Nitrospirae	40117|Nitrospirae	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
LZS2_k127_1768816_28	1201290.M902_1260	1.658e-07	62.0	2DF32@1|root,2ZQA0@2|Bacteria	2|Bacteria	S	RES domain	-	-	-	-	-	-	-	-	-	-	-	-	RES
LZS2_k127_1768816_29	330214.NIDE1410	1.7e-06	50.0	COG0248@1|root,COG0248@2|Bacteria,3J0K5@40117|Nitrospirae	40117|Nitrospirae	FP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
LZS2_k127_1768816_23	314285.KT71_08907	4.593e-19	89.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,1SCYV@1236|Gammaproteobacteria,1J77R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
LZS2_k127_1768816_25	671143.DAMO_0737	3.944e-16	83.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1768816_8	330214.NIDE1410	7.094e-124	405.0	COG0248@1|root,COG0248@2|Bacteria,3J0K5@40117|Nitrospirae	40117|Nitrospirae	FP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
LZS2_k127_1768816_1	330214.NIDE1408	4.2e-321	1004.0	COG1200@1|root,COG1200@2|Bacteria,3J0E8@40117|Nitrospirae	40117|Nitrospirae	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
LZS2_k127_1768816_5	330214.NIDE1407	2.809e-159	516.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	ko:K02453,ko:K02660	ko02020,ko02025,ko03070,ko05111,map02020,map02025,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	ANAPC5,CarboxypepD_reg,HTH_18,OmpA,PD40,TPR_16,TPR_8,Wzy_C
LZS2_k127_1768816_15	443144.GM21_2149	7.099e-46	179.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM O-methyltransferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
LZS2_k127_1768816_6	330214.NIDE1402	2.192e-134	432.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE1402|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1768816_11	330214.NIDE1401	5.481e-86	288.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_5
LZS2_k127_1768816_12	330214.NIDE1399	3.644e-70	241.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
LZS2_k127_1768816_2	330214.NIDE1393	1.3e-261	811.0	COG0034@1|root,COG0034@2|Bacteria,3J0C5@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
LZS2_k127_1768816_0	330214.NIDE1392	0.0	1152.0	COG0046@1|root,COG0046@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
LZS2_k127_1768816_9	330214.NIDE1391	2.602e-122	395.0	COG0047@1|root,COG0047@2|Bacteria,3J10Q@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
LZS2_k127_1768816_17	330214.NIDE1390	1.02e-35	136.0	COG1828@1|root,COG1828@2|Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.2.6,6.3.5.3	ko:K01923,ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463,R04591	RC00010,RC00064,RC00162,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
LZS2_k127_1768816_7	330214.NIDE1388	2.524e-124	401.0	COG0152@1|root,COG0152@2|Bacteria,3J0U6@40117|Nitrospirae	40117|Nitrospirae	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
LZS2_k127_1768816_10	330214.NIDE1387	3.244e-87	297.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114	1.13.11.49	ko:K09162	-	-	-	-	ko00000,ko01000	-	-	-	Chlor_dismutase
LZS2_k127_1768816_3	330214.NIDE1386	2.47e-229	717.0	COG0015@1|root,COG0015@2|Bacteria,3J0EM@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
LZS2_k127_1768816_14	330214.NIDE1385	7.198e-53	192.0	COG0781@1|root,COG0781@2|Bacteria,3J0RV@40117|Nitrospirae	40117|Nitrospirae	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
LZS2_k127_1768816_13	330214.NIDE1384	4.284e-57	207.0	COG0054@1|root,COG0054@2|Bacteria,3J0QT@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
LZS2_k127_1768816_4	330214.NIDE1383	3.24e-215	672.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,3J0E0@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
LZS2_k127_1768816_26	330214.NIDE1382	3.141e-15	78.0	COG2223@1|root,COG2223@2|Bacteria,3J0YQ@40117|Nitrospirae	40117|Nitrospirae	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
LZS2_k127_1812259_4	330214.NIDE3558	2.1e-58	203.0	COG0316@1|root,COG0316@2|Bacteria,3J0TZ@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the HesB IscA family	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
LZS2_k127_1812259_5	330214.NIDE3559	3.482e-49	179.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	fdx	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
LZS2_k127_1812259_0	330214.NIDE3560	9.89e-249	771.0	COG1894@1|root,COG1894@2|Bacteria,3J0WA@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
LZS2_k127_1812259_2	330214.NIDE3561	1.079e-104	342.0	COG3748@1|root,COG3748@2|Bacteria,3J19B@40117|Nitrospirae	40117|Nitrospirae	S	Pfam:DUF989	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
LZS2_k127_1812259_1	330214.NIDE3562	3.217e-153	488.0	COG0039@1|root,COG0039@2|Bacteria,3J0EG@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
LZS2_k127_1812259_3	330214.NIDE3563	3.133e-63	219.0	2DESJ@1|root,2ZP2P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1812259_6	330214.NIDE3564	8.363e-43	159.0	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
LZS2_k127_1813488_0	330214.NIDE1895	2.054e-20	96.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	hesB	-	-	ko:K07390,ko:K13628,ko:K15724	-	-	-	-	ko00000,ko03016,ko03029,ko03110	-	-	-	Fe-S_biosyn,Glutaredoxin,NifU,Rhodanese
LZS2_k127_1817023_1	330214.NIDE1107	2.577e-156	496.0	COG0057@1|root,COG0057@2|Bacteria,3J0D8@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
LZS2_k127_1817023_0	330214.NIDE1108	1.395e-291	915.0	COG1193@1|root,COG1193@2|Bacteria,3J0Y0@40117|Nitrospirae	40117|Nitrospirae	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
LZS2_k127_1869565_9	330214.NIDE3582	3.61e-57	199.0	COG0278@1|root,COG0278@2|Bacteria	2|Bacteria	O	protein disulfide oxidoreductase activity	grxD	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	iPC815.YPO2383,iYL1228.KPN_01992	Glutaredoxin
LZS2_k127_1869565_10	330214.NIDE3583	8.426e-26	109.0	COG0271@1|root,COG0271@2|Bacteria	2|Bacteria	T	Belongs to the BolA IbaG family	bolA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576	-	ko:K05527,ko:K22066	-	-	-	-	ko00000,ko03000,ko03029	-	-	-	BolA
LZS2_k127_1869565_6	330214.NIDE3585	2.461e-73	250.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PIG-L,Response_reg
LZS2_k127_1869565_2	330214.NIDE3586	8.174e-127	417.0	COG1086@1|root,COG4191@1|root,COG1086@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf,CoA_binding_3,Glycos_transf_4,HATPase_c,HisKA,LicD,PAS,PAS_9,Response_reg
LZS2_k127_1869565_0	330214.NIDE3587	3.98e-310	970.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_9,PilJ,Response_reg,SpoIIE
LZS2_k127_1869565_5	330214.NIDE3588	1.376e-76	262.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF4041,GGDEF,HATPase_c,HisKA,Response_reg,T5orf172,dCache_1
LZS2_k127_1869565_3	330214.NIDE3589	2.614e-119	393.0	COG0628@1|root,COG0628@2|Bacteria,3J0SZ@40117|Nitrospirae	40117|Nitrospirae	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
LZS2_k127_1869565_8	330214.NIDE3590	2.087e-57	203.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,zf-HC2
LZS2_k127_1869565_1	330214.NIDE3591	2.097e-268	846.0	COG0744@1|root,COG0744@2|Bacteria,3J1FP@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
LZS2_k127_1869565_4	330214.NIDE0805	4.686e-109	374.0	COG0784@1|root,COG2198@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,3J0ZF@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_1869565_12	1286631.X805_37150	3.667e-05	52.0	2DFIV@1|root,2ZS11@2|Bacteria,1P5QE@1224|Proteobacteria,2W60V@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1869565_7	215803.DB30_0218	2.605e-62	237.0	COG4191@1|root,COG4191@2|Bacteria,1R3RN@1224|Proteobacteria,42Z3W@68525|delta/epsilon subdivisions,2WTQ3@28221|Deltaproteobacteria,2YYEP@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4
LZS2_k127_1869565_11	330214.NIDE3135	1.38e-05	49.0	COG0726@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG0726@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	3.2.1.156	ko:K13735,ko:K15125,ko:K15531	ko05100,ko05133,map05100,map05133	-	-	-	ko00000,ko00001,ko00536,ko01000	-	GH8	-	DUF4347,PATR,VPEP
LZS2_k127_1877914_1	330214.NIDE2035	1.296e-131	426.0	COG1253@1|root,COG1253@2|Bacteria,3J0KN@40117|Nitrospirae	40117|Nitrospirae	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
LZS2_k127_1877914_2	330214.NIDE2034	1.551e-75	259.0	COG0797@1|root,COG0797@2|Bacteria,3J0PD@40117|Nitrospirae	40117|Nitrospirae	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
LZS2_k127_1877914_3	330214.NIDE2033	1.592e-62	217.0	COG4747@1|root,COG4747@2|Bacteria,3J1DW@40117|Nitrospirae	40117|Nitrospirae	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
LZS2_k127_1877914_0	330214.NIDE1937	0.0	1819.0	COG0209@1|root,COG0209@2|Bacteria,3J0MG@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
LZS2_k127_1899472_4	583345.Mmol_0875	8.055e-05	49.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria	28216|Betaproteobacteria	NT	chemotaxis	aer	-	-	ko:K03406,ko:K03776	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,PAS_3,TarH
LZS2_k127_1899472_2	102129.Lepto7375DRAFT_2108	1.408e-64	254.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS_3,PAS_9,PHY
LZS2_k127_1899472_1	330214.NIDE3462	6.524e-106	389.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	MA20_35625	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9
LZS2_k127_1899472_3	330214.NIDE3461	3.57e-51	192.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
LZS2_k127_1899472_0	316055.RPE_1195	9.195e-172	572.0	COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JWMW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	methyl-accepting chemotaxis protein (MCP)	mcpT	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Cache_3-Cache_2,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9,sCache_3_3
LZS2_k127_189978_4	330214.NIDE2933	5.717e-52	188.0	COG0523@1|root,COG0523@2|Bacteria	2|Bacteria	P	cobalamin synthesis protein	COBW1	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
LZS2_k127_189978_2	330214.NIDE2934	2.515e-63	222.0	COG0671@1|root,COG0671@2|Bacteria,3J155@40117|Nitrospirae	40117|Nitrospirae	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,PMT_2
LZS2_k127_189978_0	330214.NIDE2967	0.0	1235.0	COG4774@1|root,COG4774@2|Bacteria	2|Bacteria	P	siderophore transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
LZS2_k127_189978_1	330214.NIDE2969	1.518e-135	434.0	COG0722@1|root,COG0722@2|Bacteria	2|Bacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2375,iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934	DAHP_synth_1
LZS2_k127_1967794_3	706587.Desti_1182	2.493e-07	54.0	COG0457@1|root,COG0457@2|Bacteria	706587.Desti_1182|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_1967794_0	1232437.KL662042_gene2012	2.833e-144	469.0	COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,42VCD@68525|delta/epsilon subdivisions,2WRUC@28221|Deltaproteobacteria,2MMEZ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
LZS2_k127_1967794_1	1232437.KL662042_gene2011	1.167e-91	308.0	COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,42Y9C@68525|delta/epsilon subdivisions,2WUJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
LZS2_k127_1989103_4	330214.NIDE1273	7.648e-30	121.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
LZS2_k127_1989103_0	330214.NIDE1274	2.977e-138	451.0	COG4974@1|root,COG4974@2|Bacteria,3J1FQ@40117|Nitrospirae	40117|Nitrospirae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
LZS2_k127_1989103_5	1321778.HMPREF1982_02413	4.196e-19	94.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,26ATW@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,PocR
LZS2_k127_1989103_2	330214.NIDE1763	1.032e-34	137.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HisKA,LpxC,PAS_3,Response_reg
LZS2_k127_1989103_1	1396141.BATP01000007_gene5548	3.503e-42	159.0	COG2304@1|root,COG2304@2|Bacteria,46VTY@74201|Verrucomicrobia	2|Bacteria	G	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,FG-GAP_2,FctA,VWA,VWA_2
LZS2_k127_1991022_25	330214.NIDE4057	9.622e-07	53.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
LZS2_k127_1991022_8	330214.NIDE4064	1.069e-82	284.0	COG1774@1|root,COG1774@2|Bacteria,3J0MI@40117|Nitrospirae	40117|Nitrospirae	S	PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
LZS2_k127_1991022_17	330214.NIDE4065	1.236e-40	151.0	COG2856@1|root,COG2856@2|Bacteria	2|Bacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M78
LZS2_k127_1991022_10	330214.NIDE4066	7.7e-67	232.0	COG2947@1|root,COG2947@2|Bacteria	2|Bacteria	L	Ubiquinol--cytochrome c reductase	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
LZS2_k127_1991022_9	330214.NIDE4069	5.466e-82	280.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
LZS2_k127_1991022_7	330214.NIDE4070	1.088e-94	314.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
LZS2_k127_1991022_2	330214.NIDE4073	1.756e-204	651.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	VPA1441	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp,FG-GAP_2,OprD,Porin_4
LZS2_k127_1991022_19	330214.NIDE4074	2.101e-35	136.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
LZS2_k127_1991022_22	330214.NIDE4075	1.106e-24	106.0	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
LZS2_k127_1991022_3	330214.NIDE0368	9.54e-156	499.0	COG0482@1|root,COG0482@2|Bacteria,3J0KT@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	-	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
LZS2_k127_1991022_14	330214.NIDE0367	1.208e-46	172.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,zf-HC2
LZS2_k127_1991022_13	330214.NIDE0366	1.627e-48	179.0	COG1664@1|root,COG1664@2|Bacteria,3J1F5@40117|Nitrospirae	40117|Nitrospirae	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
LZS2_k127_1991022_11	1049564.TevJSym_aq00390	1.193e-61	224.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1J52T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
LZS2_k127_1991022_6	330214.NIDE0364	1.671e-110	362.0	COG1192@1|root,COG1192@2|Bacteria,3J0H4@40117|Nitrospirae	40117|Nitrospirae	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
LZS2_k127_1991022_18	330214.NIDE0363	4.156e-38	151.0	COG0357@1|root,COG0357@2|Bacteria,3J18F@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N7 position of a guanine in 16S rRNA	gidB	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
LZS2_k127_1991022_0	330214.NIDE0362	1.662e-287	895.0	COG0445@1|root,COG0445@2|Bacteria,3J0E9@40117|Nitrospirae	40117|Nitrospirae	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
LZS2_k127_1991022_4	330214.NIDE0361	1.794e-132	437.0	COG0486@1|root,COG0486@2|Bacteria,3J0JZ@40117|Nitrospirae	40117|Nitrospirae	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	trmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
LZS2_k127_1991022_1	330214.NIDE0360	1.063e-206	657.0	COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae	40117|Nitrospirae	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
LZS2_k127_1991022_20	1173264.KI913949_gene3743	5.076e-26	109.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1HCVK@1150|Oscillatoriales	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
LZS2_k127_1991022_21	330214.NIDE0359	8.619e-26	110.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
LZS2_k127_1991022_24	1120963.KB894492_gene1423	3.214e-10	61.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria,2Q3CH@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
LZS2_k127_1991022_23	518766.Rmar_0609	2.073e-11	72.0	2FFT5@1|root,347QA@2|Bacteria,4P5W2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
LZS2_k127_1991022_5	330214.NIDE0357	3.389e-116	386.0	COG3034@1|root,COG3034@2|Bacteria,3J19Y@40117|Nitrospirae	40117|Nitrospirae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
LZS2_k127_1991022_16	518766.Rmar_0611	4.053e-41	159.0	COG1376@1|root,COG1376@2|Bacteria,4P35B@976|Bacteroidetes	976|Bacteroidetes	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
LZS2_k127_2017987_1	395495.Lcho_0783	4.289e-50	191.0	COG1475@1|root,COG1475@2|Bacteria,1R634@1224|Proteobacteria,2VPF5@28216|Betaproteobacteria,1KN2S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	KorB,KorB_C,ParBc
LZS2_k127_2017987_0	1219375.CM002139_gene3114	6.061e-73	255.0	COG1192@1|root,COG1192@2|Bacteria,1R5XZ@1224|Proteobacteria	1224|Proteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
LZS2_k127_2017987_2	864051.BurJ1DRAFT_4029	2.236e-33	141.0	2CHAM@1|root,32V18@2|Bacteria,1N60K@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2046256_4	330214.NIDE3282	5.339e-175	554.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	WD40
LZS2_k127_2046256_2	330214.NIDE3281	3.546e-206	642.0	2AKTZ@1|root,31BM1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2046256_9	330214.NIDE3280	1.793e-80	272.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	napG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_7
LZS2_k127_2046256_5	330214.NIDE3279	7.248e-164	520.0	COG3381@1|root,COG3381@2|Bacteria	2|Bacteria	S	protein complex oligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
LZS2_k127_2046256_3	330214.NIDE3278	1.749e-193	604.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K17052	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
LZS2_k127_2046256_0	330214.NIDE3276	0.0	1022.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
LZS2_k127_2046256_6	330214.NIDE3274	3.491e-143	457.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE3274|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2046256_11	330214.NIDE3273	4.563e-23	102.0	COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
LZS2_k127_2046256_1	330214.NIDE3272	1.082e-239	744.0	COG3391@1|root,COG3391@2|Bacteria,3J19W@40117|Nitrospirae	40117|Nitrospirae	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
LZS2_k127_2046256_7	330214.NIDE3271	4.864e-143	458.0	COG2180@1|root,COG2180@2|Bacteria	2|Bacteria	C	chaperone-mediated protein complex assembly	narJ	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057	-	ko:K00373,ko:K17052	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	5.A.3.8	-	iE2348C_1286.E2348C_1350,iECABU_c1320.ECABU_c15020,iECIAI1_1343.ECIAI1_1469,iECO103_1326.ECO103_1331,iECO111_1330.ECO111_1557,iECW_1372.ECW_m1594,iEKO11_1354.EKO11_2354,iLF82_1304.LF82_1462,iNRG857_1313.NRG857_06280,iSSON_1240.SSON_1659,iWFL_1372.ECW_m1594,ic_1306.c1687	Nitrate_red_del
LZS2_k127_2094109_0	330214.NIDE1639	7.43e-192	604.0	COG0477@1|root,COG2814@2|Bacteria,3J1DQ@40117|Nitrospirae	40117|Nitrospirae	EGP	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
LZS2_k127_2094109_1	330214.NIDE1641	4.98e-95	317.0	COG0307@1|root,COG0307@2|Bacteria,3J0PR@40117|Nitrospirae	40117|Nitrospirae	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
LZS2_k127_2094109_4	330214.NIDE2513	3.16e-14	75.0	2DGSC@1|root,2ZX3U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2094109_3	330214.NIDE2512	4.125e-45	167.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
LZS2_k127_2127704_3	1267535.KB906767_gene3728	1.007e-23	108.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
LZS2_k127_2127704_0	243231.GSU0801	3.143e-86	305.0	COG3637@1|root,COG3637@2|Bacteria,1QUUK@1224|Proteobacteria	1224|Proteobacteria	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
LZS2_k127_2127704_4	929556.Solca_1806	1.475e-23	107.0	2E3RZ@1|root,32YPK@2|Bacteria,4NVPS@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2127704_5	1340493.JNIF01000003_gene4537	6.363e-21	104.0	COG2823@1|root,COG2823@2|Bacteria,3Y4KR@57723|Acidobacteria	57723|Acidobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
LZS2_k127_2127704_6	1454004.AW11_01640	9.379e-09	66.0	28IHQ@1|root,2Z8IX@2|Bacteria,1PX3U@1224|Proteobacteria,2VWXF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
LZS2_k127_2127704_1	1279009.ADICEAN_01483	2.213e-76	276.0	COG0668@1|root,COG0668@2|Bacteria,4NFC6@976|Bacteroidetes,47YNQ@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	mscM	-	-	-	-	-	-	-	-	-	-	-	MS_channel
LZS2_k127_2239547_0	330214.NIDE2055	5.94e-197	626.0	COG0815@1|root,COG0815@2|Bacteria,3J0HA@40117|Nitrospirae	40117|Nitrospirae	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
LZS2_k127_2242778_3	330214.NIDE3727	9.488e-201	647.0	COG0457@1|root,COG0741@1|root,COG1729@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,COG1729@2|Bacteria,3J0VD@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_3,TPR_6
LZS2_k127_2242778_4	330214.NIDE3728	3.882e-126	417.0	COG0820@1|root,COG0820@2|Bacteria,3J0CH@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
LZS2_k127_2242778_1	330214.NIDE3729	3.738e-221	693.0	COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
LZS2_k127_2242778_2	330214.NIDE3730	1.141e-206	651.0	COG0612@1|root,COG0612@2|Bacteria,3J0I5@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
LZS2_k127_2242778_7	330214.NIDE3731	1.374e-109	360.0	COG1606@1|root,COG1606@2|Bacteria	2|Bacteria	L	tRNA processing	larE	-	4.99.1.12	ko:K06864,ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
LZS2_k127_2242778_11	330214.NIDE3732	6.929e-74	251.0	COG0711@1|root,COG0711@2|Bacteria,3J1AE@40117|Nitrospirae	40117|Nitrospirae	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
LZS2_k127_2242778_13	330214.NIDE3733	1.519e-32	127.0	COG0636@1|root,COG0636@2|Bacteria,3J198@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
LZS2_k127_2242778_6	330214.NIDE3734	9.53e-114	371.0	COG0356@1|root,COG0356@2|Bacteria,3J0RW@40117|Nitrospirae	40117|Nitrospirae	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
LZS2_k127_2242778_14	330214.NIDE3735	2.122e-28	116.0	COG5336@1|root,COG5336@2|Bacteria	2|Bacteria	C	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
LZS2_k127_2242778_8	272558.10172702	1.737e-109	371.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4HB31@91061|Bacilli,1ZARE@1386|Bacillus	91061|Bacilli	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
LZS2_k127_2242778_5	330214.NIDE3737	1.239e-124	407.0	COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae	2|Bacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	pabC	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
LZS2_k127_2242778_10	330214.NIDE3738	5.938e-82	278.0	COG0741@1|root,COG0741@2|Bacteria,3J19T@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
LZS2_k127_2242778_0	330214.NIDE3739	8.041e-253	790.0	COG0029@1|root,COG0029@2|Bacteria,3J0DI@40117|Nitrospirae	40117|Nitrospirae	H	FAD binding domain	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
LZS2_k127_2242778_9	765914.ThisiDRAFT_2091	1.935e-86	301.0	COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,rve
LZS2_k127_2250749_2	330214.NIDE0326	1.419e-124	404.0	COG1611@1|root,COG1611@2|Bacteria,3J169@40117|Nitrospirae	40117|Nitrospirae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
LZS2_k127_2250749_0	330214.NIDE0325	1.267e-239	747.0	COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae	40117|Nitrospirae	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
LZS2_k127_2250749_1	330214.NIDE0324	8.334e-150	482.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
LZS2_k127_2252184_3	330214.NIDE3747	1.251e-13	71.0	2CIIF@1|root,315FB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2252184_4	330214.NIDE4358	1.094e-11	67.0	2CG7F@1|root,2ZUI2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2252184_0	330214.NIDE3374	8.369e-145	467.0	28I4Y@1|root,2Z88D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2252184_1	330214.NIDE3376	2.553e-69	237.0	2ETMV@1|root,33M5M@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
LZS2_k127_2255602_1	237368.SCABRO_03149	2.893e-19	91.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	RHH_1
LZS2_k127_2255602_0	323261.Noc_1568	3.754e-48	175.0	COG2337@1|root,COG2337@2|Bacteria,1RIPH@1224|Proteobacteria,1S7VW@1236|Gammaproteobacteria,1WYQY@135613|Chromatiales	135613|Chromatiales	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
LZS2_k127_2255602_4	330214.NIDE1487	6.405e-08	61.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Hpt,Response_reg
LZS2_k127_2255602_2	1396141.BATP01000028_gene2285	3.195e-16	88.0	COG4412@1|root,COG5306@1|root,COG4412@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K07004,ko:K09955,ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_4,F5_F8_type_C,Laminin_G_3
LZS2_k127_2257934_1	1131269.AQVV01000018_gene1905	2.684e-87	299.0	COG1972@1|root,COG1972@2|Bacteria	2|Bacteria	F	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family	yeiM	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
LZS2_k127_2257934_2	1296416.JACB01000042_gene1780	1.134e-34	154.0	COG2304@1|root,COG3591@1|root,COG2304@2|Bacteria,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Big_2,NB-ARC,PKD,PPC,Sel1,Trypsin,Trypsin_2,VWA,VWA_2
LZS2_k127_2257934_0	330214.NIDE3622	1.298e-230	725.0	COG0025@1|root,COG0025@2|Bacteria	2|Bacteria	P	sodium:proton antiporter activity	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,zf-UBP
LZS2_k127_2257934_3	1173020.Cha6605_3683	1.176e-20	94.0	COG0451@1|root,COG0451@2|Bacteria,1G2VR@1117|Cyanobacteria	1117|Cyanobacteria	M	CDP-glucose 4,6-dehydratase	-	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
LZS2_k127_2290001_2	330214.NIDE3445	4.976e-152	493.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3J0J4@40117|Nitrospirae	40117|Nitrospirae	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
LZS2_k127_2290001_4	330214.NIDE3446	9.005e-86	290.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
LZS2_k127_2290001_3	330214.NIDE3447	1.992e-148	479.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	2|Bacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iJN678.bioF,iNJ661.Rv1569	Aminotran_1_2
LZS2_k127_2290001_1	330214.NIDE3448	7.099e-202	633.0	COG2805@1|root,COG2805@2|Bacteria,3J0YS@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
LZS2_k127_2290001_0	330214.NIDE3449	2.652e-213	666.0	COG5008@1|root,COG5008@2|Bacteria	2|Bacteria	NU	twitching motility protein	pilU	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
LZS2_k127_2290001_7	330214.NIDE3450	2.137e-42	161.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	ccoP	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrom_C,Cytochrome_CBB3,FixO
LZS2_k127_2290001_6	330214.NIDE4290	3.612e-46	170.0	COG3753@1|root,COG3753@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF937)	yidB	-	-	-	-	-	-	-	-	-	-	-	DUF937
LZS2_k127_2290001_5	330214.NIDE0786	6.351e-57	205.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	CBP_BcsS,OMP_b-brl
LZS2_k127_2290001_8	478741.JAFS01000002_gene811	4.919e-13	76.0	COG3065@1|root,COG3065@2|Bacteria,46YII@74201|Verrucomicrobia,37GMN@326457|unclassified Verrucomicrobia	2|Bacteria	M	Outer membrane lipoprotein Slp family	slp	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
LZS2_k127_2298994_2	330214.NIDE2493	3.425e-186	588.0	COG1355@1|root,COG1355@2|Bacteria,3J0U4@40117|Nitrospirae	40117|Nitrospirae	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
LZS2_k127_2298994_0	330214.NIDE3937	0.0	3104.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
LZS2_k127_2298994_3	330214.NIDE3935	8.281e-142	454.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_2298994_1	330214.NIDE3313	0.0	2988.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K07233,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3
LZS2_k127_2298994_5	330214.NIDE3936	2.637e-59	209.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
LZS2_k127_2305990_5	1519464.HY22_11200	7.233e-11	73.0	29GIK@1|root,303GA@2|Bacteria,1FFGG@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2305990_2	525897.Dbac_2169	5.231e-40	154.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	MA20_14850	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_2305990_1	1167006.UWK_00988	9.327e-47	172.0	2BK9M@1|root,32EPT@2|Bacteria,1NC6I@1224|Proteobacteria,42XFJ@68525|delta/epsilon subdivisions,2WT5J@28221|Deltaproteobacteria,2MP6B@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2305990_0	452637.Oter_2251	3.763e-52	198.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
LZS2_k127_2305990_4	153948.NAL212_2787	1.513e-26	111.0	2AHT0@1|root,3185H@2|Bacteria,1PZUW@1224|Proteobacteria,2WC28@28216|Betaproteobacteria,373KC@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2305990_3	1165096.ARWF01000001_gene2179	8.027e-27	114.0	2B4TG@1|root,31XK1@2|Bacteria,1RIY8@1224|Proteobacteria,2VTMB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2336116_5	330214.NIDE0403	1.961e-37	143.0	COG0441@1|root,COG0441@2|Bacteria,3J0F4@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
LZS2_k127_2336116_3	330214.NIDE0402	1.949e-87	292.0	COG0290@1|root,COG0290@2|Bacteria,3J0T0@40117|Nitrospirae	40117|Nitrospirae	J	Translation initiation factor IF-3, C-terminal domain	-	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
LZS2_k127_2336116_7	330214.NIDE0401	1.029e-13	73.0	COG0291@1|root,COG0291@2|Bacteria,3J1F4@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
LZS2_k127_2336116_4	330214.NIDE0400	4.969e-53	189.0	COG0292@1|root,COG0292@2|Bacteria,3J0SF@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
LZS2_k127_2336116_1	330214.NIDE0399	6.792e-248	777.0	COG0072@1|root,COG0072@2|Bacteria,3J0U7@40117|Nitrospirae	40117|Nitrospirae	J	B3/4 domain	-	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5
LZS2_k127_2336116_0	330214.NIDE0398	4.169e-248	777.0	COG0016@1|root,COG0016@2|Bacteria,3J0SW@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
LZS2_k127_2336116_2	330214.NIDE0397	5.237e-100	331.0	COG0036@1|root,COG0036@2|Bacteria,3J0IZ@40117|Nitrospirae	40117|Nitrospirae	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
LZS2_k127_2336116_6	330214.NIDE0396	1.105e-17	84.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3J136@40117|Nitrospirae	40117|Nitrospirae	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
LZS2_k127_2351796_3	1125863.JAFN01000001_gene2971	2.34e-27	123.0	COG3031@1|root,COG3031@2|Bacteria,1PUWN@1224|Proteobacteria,42T73@68525|delta/epsilon subdivisions,2WR4E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
LZS2_k127_2351796_0	330214.NIDE3012	8.711e-180	567.0	COG1089@1|root,COG1089@2|Bacteria,3J0YR@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
LZS2_k127_2351796_4	388413.ALPR1_09895	1.502e-21	99.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	23S_rRNA_IVP,DegT_DnrJ_EryC1
LZS2_k127_2351796_1	290397.Adeh_4286	1.544e-146	470.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,42M12@68525|delta/epsilon subdivisions,2WIJX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1312	Epimerase
LZS2_k127_2351796_2	330214.NIDE2377	2.79e-44	162.0	COG0381@1|root,COG0381@2|Bacteria,3J148@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
LZS2_k127_2357400_10	330214.NIDE2564	3.544e-27	110.0	2EI4B@1|root,33BVP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_15	760192.Halhy_5272	1.81e-16	81.0	2D2Z4@1|root,32TDX@2|Bacteria,4NVF7@976|Bacteroidetes,1IYZR@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF3024)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3024
LZS2_k127_2357400_30	338963.Pcar_2800	0.0001088	45.0	2AUDM@1|root,32J1F@2|Bacteria,1Q8YE@1224|Proteobacteria,42WAN@68525|delta/epsilon subdivisions,2WRIX@28221|Deltaproteobacteria,43SR8@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3024)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3024
LZS2_k127_2357400_29	449673.BACSTE_03846	7.47e-05	47.0	2AHEJ@1|root,317RR@2|Bacteria,4P93N@976|Bacteroidetes,2FZC5@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_14	880072.Desac_2844	6.976e-17	83.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,42S33@68525|delta/epsilon subdivisions,2WNKG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_3	536233.CLO_3903	1.898e-46	168.0	2CW0Y@1|root,32SYT@2|Bacteria,1V76P@1239|Firmicutes,25FS4@186801|Clostridia,36UZ5@31979|Clostridiaceae	186801|Clostridia	S	the current gene model (or a revised gene model) may contain a premature stop	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_26	592027.CLG_B2349	1.553e-06	52.0	2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,24JC8@186801|Clostridia,36RET@31979|Clostridiaceae	186801|Clostridia	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_12	926549.KI421517_gene1486	5.114e-20	90.0	2B9ZZ@1|root,323DM@2|Bacteria,4NTEB@976|Bacteroidetes,47VWB@768503|Cytophagia	976|Bacteroidetes	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_13	632245.CLP_0945	7.326e-19	90.0	2ED6K@1|root,3373A@2|Bacteria,1VI2S@1239|Firmicutes,24QZV@186801|Clostridia,36TJ8@31979|Clostridiaceae	186801|Clostridia	S	the current gene model (or a revised gene model) may contain one or more premature stops and or frameshifts	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_19	509191.AEDB02000057_gene2098	1.311e-10	62.0	2DQE0@1|root,33689@2|Bacteria,1VH8J@1239|Firmicutes,24WJ6@186801|Clostridia,3WQ79@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_17	243230.DR_2252	1.872e-12	67.0	2ED08@1|root,33H8A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_16	1110697.NCAST_03_00005	3.151e-14	74.0	2DQZN@1|root,339JB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_11	471874.PROSTU_01097	1.482e-22	101.0	2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,1TEB6@1236|Gammaproteobacteria,3ZA81@586|Providencia	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_20	1203606.HMPREF1526_02587	2.126e-10	64.0	2DPDN@1|root,331NP@2|Bacteria,1VFF8@1239|Firmicutes,24S9D@186801|Clostridia,36VF0@31979|Clostridiaceae	186801|Clostridia	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_28	202955.BBND01000043_gene1756	3.149e-05	46.0	2E4EA@1|root,32Z9I@2|Bacteria,1N7HE@1224|Proteobacteria,1SDU5@1236|Gammaproteobacteria,3NP71@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_23	929794.CALV01000065_gene1616	8.919e-10	62.0	2E4EA@1|root,32Z9I@2|Bacteria,1PWSF@1224|Proteobacteria,2V587@28211|Alphaproteobacteria,48UAE@772|Bartonellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_32	1121870.AUAA01000078_gene1196	0.000368	49.0	2DMHR@1|root,32RMI@2|Bacteria,4NUR9@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_4	1304875.JAFZ01000002_gene1	2.966e-43	162.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_25	1550091.JROE01000032_gene4174	5.554e-07	51.0	2EK6X@1|root,33DXA@2|Bacteria,4NY6H@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_8	411467.BACCAP_03832	2.564e-33	131.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_22	887929.HMP0721_2517	6.08e-10	61.0	2DGK2@1|root,2ZWBC@2|Bacteria,1W4NY@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2357400_0	330214.NIDE1441	8.52e-172	544.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	nia	-	1.8.3.1	ko:K00387	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
LZS2_k127_2357400_7	330214.NIDE0676	1.467e-35	142.0	COG3065@1|root,COG3065@2|Bacteria,3J1BB@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
LZS2_k127_2357400_2	1322246.BN4_12286	5.856e-61	217.0	28NM7@1|root,2ZBMT@2|Bacteria,1R9Y9@1224|Proteobacteria,42RRM@68525|delta/epsilon subdivisions,2WNWI@28221|Deltaproteobacteria,2MBBB@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2959)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2959
LZS2_k127_2357400_1	330214.NIDE1431	2.788e-136	439.0	COG2321@1|root,COG2321@2|Bacteria	2|Bacteria	S	Putative neutral zinc metallopeptidase	ypfJ	GO:0005575,GO:0005576	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
LZS2_k127_2357400_21	330214.NIDE1415	4.647e-10	70.0	COG1750@1|root,COG1750@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lon_C,SdrD_B
LZS2_k127_2357400_6	330214.NIDE1428	1.02e-35	136.0	COG1119@1|root,COG1119@2|Bacteria	2|Bacteria	P	ATPase activity	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21,3.6.3.34	ko:K02013,ko:K02028,ko:K05776	ko02010,map02010	M00189,M00236,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.3	-	-	ABC_tran
LZS2_k127_2376182_4	330214.NIDE0825	1.528e-08	55.0	COG1144@1|root,COG1144@2|Bacteria,3J1A9@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2376182_1	330214.NIDE0826	8.537e-154	488.0	COG0226@1|root,COG0226@2|Bacteria,3J0YH@40117|Nitrospirae	2|Bacteria	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	forD	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	CO_dh,PBP_like_2
LZS2_k127_2376182_0	330214.NIDE0827	2.419e-263	814.0	COG0674@1|root,COG0674@2|Bacteria,3J105@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
LZS2_k127_2376182_2	330214.NIDE0829	1.365e-109	368.0	COG5459@1|root,COG5459@2|Bacteria,3J16W@40117|Nitrospirae	40117|Nitrospirae	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
LZS2_k127_2379655_3	1121374.KB891586_gene2876	1.348e-09	69.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
LZS2_k127_2379655_2	330214.NIDE2321	1.916e-27	113.0	COG1551@1|root,COG1551@2|Bacteria	2|Bacteria	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563,ko:K13626	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko02035,ko03019	-	-	-	CsrA
LZS2_k127_2379655_1	330214.NIDE2322	5.845e-56	199.0	COG1699@1|root,COG1699@2|Bacteria,3J0V2@40117|Nitrospirae	40117|Nitrospirae	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
LZS2_k127_2379655_0	330214.NIDE2323	2.126e-93	316.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,3J0ZF@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,CHASE8,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
LZS2_k127_2383464_7	1453505.JASY01000010_gene3925	8.488e-59	218.0	2B5SQ@1|root,31YND@2|Bacteria,4P034@976|Bacteroidetes,1I8EZ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2383464_8	78398.KS43_02255	2.239e-56	203.0	2AIFV@1|root,318XE@2|Bacteria,1QF2N@1224|Proteobacteria,1TC4K@1236|Gammaproteobacteria,1MRI5@122277|Pectobacterium	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2383464_13	330214.NIDE1072	3.165e-29	117.0	2DP6Q@1|root,330SE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2383464_12	330214.NIDE1071	1.313e-30	122.0	2E46S@1|root,32Z2Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2383464_11	305900.GV64_11420	2.968e-31	130.0	290RU@1|root,2ZNDZ@2|Bacteria,1P98B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2383464_2	945713.IALB_1765	5.499e-136	446.0	COG1252@1|root,COG1252@2|Bacteria	2|Bacteria	C	NADH dehydrogenase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
LZS2_k127_2383464_1	945713.IALB_1765	1.831e-139	455.0	COG1252@1|root,COG1252@2|Bacteria	2|Bacteria	C	NADH dehydrogenase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
LZS2_k127_2383464_5	330214.NIDE3460	1.467e-76	263.0	COG3040@1|root,COG3040@2|Bacteria	2|Bacteria	M	lipid binding	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
LZS2_k127_2383464_6	330214.NIDE1889	5.897e-76	256.0	COG0229@1|root,COG0229@2|Bacteria,3J17K@40117|Nitrospirae	40117|Nitrospirae	C	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
LZS2_k127_2383464_3	330214.NIDE1138	1.289e-112	372.0	COG2084@1|root,COG2084@2|Bacteria,3J0YI@40117|Nitrospirae	40117|Nitrospirae	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
LZS2_k127_2383464_9	330214.NIDE1884	2.849e-50	184.0	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	dsbL	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin_4
LZS2_k127_2383464_4	330214.NIDE0805	1.27e-102	359.0	COG0784@1|root,COG2198@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,3J0ZF@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_2383464_15	1304885.AUEY01000027_gene2362	3.788e-21	97.0	COG1558@1|root,COG1558@2|Bacteria,1R09B@1224|Proteobacteria,43CSB@68525|delta/epsilon subdivisions,2X7ZY@28221|Deltaproteobacteria,2MPMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	-	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
LZS2_k127_2383464_0	330214.NIDE1878	2.309e-269	847.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
LZS2_k127_2383464_16	323848.Nmul_A2236	4.8e-08	55.0	COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria,372PW@32003|Nitrosomonadales	28216|Betaproteobacteria	S	short chain amide porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
LZS2_k127_2383465_1	323848.Nmul_A2236	4.8e-08	55.0	COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria,372PW@32003|Nitrosomonadales	28216|Betaproteobacteria	S	short chain amide porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
LZS2_k127_2383465_0	330214.NIDE1052	8.623e-64	221.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
LZS2_k127_2383465_2	1227495.C487_14649	0.0001823	50.0	COG3540@1|root,arCOG09293@2157|Archaea,2XYER@28890|Euryarchaeota,23WCF@183963|Halobacteria	183963|Halobacteria	P	COG3540 Phosphodiesterase alkaline phosphatase D	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_B,PhoD,PhoD_N
LZS2_k127_2383859_1	330214.NIDE1157	1.496e-150	483.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
LZS2_k127_2383859_0	330214.NIDE1160	1.464e-158	509.0	COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae	2|Bacteria	E	Evidence 2b Function of strongly homologous gene	spt	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
LZS2_k127_2383859_2	330214.NIDE1161	9.136e-124	413.0	COG1266@1|root,COG1633@1|root,COG1266@2|Bacteria,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594,ko:K07052	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Abi
LZS2_k127_2383859_3	330214.NIDE1162	1.086e-79	274.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	yeeZ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10
LZS2_k127_2383859_4	1267534.KB906754_gene2761	1.862e-26	122.0	COG2706@1|root,COG2706@2|Bacteria,3Y4E3@57723|Acidobacteria,2JJ44@204432|Acidobacteriia	204432|Acidobacteriia	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
LZS2_k127_2383859_5	1123508.JH636440_gene2291	4.768e-07	62.0	COG2706@1|root,COG2706@2|Bacteria,2J2PS@203682|Planctomycetes	203682|Planctomycetes	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
LZS2_k127_2385370_5	639030.JHVA01000001_gene2746	4.529e-70	254.0	COG2208@1|root,COG2208@2|Bacteria,3Y4A2@57723|Acidobacteria,2JJ6J@204432|Acidobacteriia	204432|Acidobacteriia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
LZS2_k127_2385370_1	991.IW20_22815	8.474e-154	519.0	COG5164@1|root,COG5164@2|Bacteria,4NFN0@976|Bacteroidetes,1IMWB@117743|Flavobacteriia,2NVM5@237|Flavobacterium	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2385370_15	94122.Shewana3_0748	1.081e-17	93.0	COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,1T0AG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	phosphoesterase, PA-phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
LZS2_k127_2385370_10	1122179.KB890497_gene2776	8.368e-38	165.0	COG3202@1|root,COG3202@2|Bacteria,4NIB2@976|Bacteroidetes,1IPY8@117747|Sphingobacteriia	976|Bacteroidetes	C	lyase activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC,cNMP_binding
LZS2_k127_2385370_18	1480694.DC28_14880	2.514e-05	58.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
LZS2_k127_2385370_2	1396141.BATP01000001_gene5403	4.653e-143	459.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia,2ITM1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
LZS2_k127_2385370_4	1089550.ATTH01000001_gene1890	4.611e-78	285.0	2AB2F@1|root,310G6@2|Bacteria,4PEZP@976|Bacteroidetes,1FJWS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2385370_16	1121104.AQXH01000001_gene1523	3.077e-08	66.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
LZS2_k127_2385370_19	1408254.T458_12060	0.0003471	53.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4HDXV@91061|Bacilli,26TY3@186822|Paenibacillaceae	91061|Bacilli	T	PAS domain	atoS	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
LZS2_k127_2385370_0	234267.Acid_2882	9.567e-183	583.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria	57723|Acidobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_2385370_20	1397528.Q671_13335	0.0007079	51.0	COG0642@1|root,COG5278@1|root,COG2205@2|Bacteria,COG5278@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,1XJ2K@135619|Oceanospirillales	135619|Oceanospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
LZS2_k127_2385370_11	1267533.KB906734_gene3731	1.293e-27	118.0	2CWBN@1|root,32SZD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2385370_14	1267535.KB906767_gene3216	8.431e-22	102.0	COG2823@1|root,COG2823@2|Bacteria,3Y3MJ@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
LZS2_k127_2385370_3	234267.Acid_3770	4.815e-127	424.0	COG3064@1|root,COG3064@2|Bacteria,3Y3WX@57723|Acidobacteria	57723|Acidobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2385370_6	317619.ANKN01000055_gene1951	1.28e-64	231.0	COG3338@1|root,COG3338@2|Bacteria,1G5J4@1117|Cyanobacteria	1117|Cyanobacteria	P	Carbonic Anhydrase	ecaA	-	4.2.1.1	ko:K01674	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Carb_anhydrase
LZS2_k127_2385370_17	519989.ECTPHS_14156	1.126e-06	57.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
LZS2_k127_2385370_13	1173024.KI912152_gene374	2.099e-26	116.0	2D8WY@1|root,32TS4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2385370_12	85643.Tmz1t_3871	7.017e-27	120.0	COG2067@1|root,COG2067@2|Bacteria,1REWT@1224|Proteobacteria,2VVIS@28216|Betaproteobacteria	28216|Betaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2385370_8	1207075.PputUW4_03478	2.603e-49	177.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S82V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
LZS2_k127_23885_9	330214.NIDE4167	7.105e-15	74.0	COG4638@1|root,COG4638@2|Bacteria	2|Bacteria	P	Rieske (2fe-2S)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
LZS2_k127_23885_0	330214.NIDE4168	3.011e-313	970.0	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,3J0Y7@40117|Nitrospirae	40117|Nitrospirae	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
LZS2_k127_23885_2	330214.NIDE4172	3.431e-172	547.0	COG0451@1|root,COG0451@2|Bacteria,3J0ZC@40117|Nitrospirae	40117|Nitrospirae	M	Male sterility protein	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
LZS2_k127_23885_1	330214.NIDE4173	1.626e-250	783.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
LZS2_k127_23885_4	330214.NIDE4174	1.104e-56	201.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
LZS2_k127_23885_7	714943.Mucpa_4956	5.054e-21	97.0	2CCSR@1|root,32RWC@2|Bacteria,4NUMI@976|Bacteroidetes,1ITWM@117747|Sphingobacteriia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS2_k127_23885_3	330214.NIDE4176	2.914e-103	342.0	COG1587@1|root,COG1587@2|Bacteria	2|Bacteria	H	uroporphyrinogen-III synthase activity	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Trans_reg_C
LZS2_k127_23885_6	909663.KI867149_gene3321	7.02e-26	109.0	COG3328@1|root,COG3328@2|Bacteria,1R81T@1224|Proteobacteria	1224|Proteobacteria	L	COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
LZS2_k127_2393960_2	330214.NIDE2493	5.69e-21	94.0	COG1355@1|root,COG1355@2|Bacteria,3J0U4@40117|Nitrospirae	40117|Nitrospirae	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
LZS2_k127_2393960_1	330214.NIDE2492	1.035e-118	386.0	2ANS9@1|root,31DS7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2393960_0	330214.NIDE2491	2.612e-150	479.0	28MYQ@1|root,2ZB5K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2393960_3	330214.NIDE2490	2.562e-10	60.0	29ZH8@1|root,30MGZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2400741_1	330214.NIDE1821	3.954e-100	329.0	COG0031@1|root,COG0031@2|Bacteria,3J0HD@40117|Nitrospirae	40117|Nitrospirae	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
LZS2_k127_2400741_9	330214.NIDE1822	2.911e-25	106.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS2_k127_2400741_5	330214.NIDE1825	1.156e-58	209.0	COG1502@1|root,COG1502@2|Bacteria,3J1DV@40117|Nitrospirae	40117|Nitrospirae	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
LZS2_k127_2400741_0	330214.NIDE1826	6.26e-183	581.0	COG0654@1|root,COG0654@2|Bacteria,3J16C@40117|Nitrospirae	40117|Nitrospirae	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
LZS2_k127_2400741_4	330214.NIDE1827	2.828e-76	264.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	ant1	-	2.7.7.47	ko:K00984,ko:K19279	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	DUF4111,NTP_transf_2,UPF0158
LZS2_k127_2400741_3	330214.NIDE1828	7.136e-82	281.0	COG1512@1|root,COG1512@2|Bacteria	2|Bacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
LZS2_k127_2400741_2	330214.NIDE3518	3.364e-85	291.0	COG1651@1|root,COG1651@2|Bacteria,3J19Z@40117|Nitrospirae	40117|Nitrospirae	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2400741_8	290317.Cpha266_0264	2.978e-34	131.0	29X02@1|root,30INB@2|Bacteria,1FFD4@1090|Chlorobi	1090|Chlorobi	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
LZS2_k127_2400741_7	290317.Cpha266_0265	2.399e-37	141.0	2BWX9@1|root,330PJ@2|Bacteria,1FFHH@1090|Chlorobi	1090|Chlorobi	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
LZS2_k127_2400741_10	672.VV93_v1c40990	7.998e-15	80.0	2EJ23@1|root,33CT8@2|Bacteria,1NHHZ@1224|Proteobacteria,1SJII@1236|Gammaproteobacteria,1XYFP@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2414298_2	1183438.GKIL_0946	1.752e-32	136.0	COG0241@1|root,COG0241@2|Bacteria,1G50D@1117|Cyanobacteria	1117|Cyanobacteria	E	Polynucleotide kinase 3 phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
LZS2_k127_2414298_0	1128421.JAGA01000002_gene1203	1.656e-126	413.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
LZS2_k127_2414298_1	1340493.JNIF01000004_gene141	8.937e-65	230.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	PRC
LZS2_k127_2415136_8	1242864.D187_002482	2.979e-35	142.0	COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
LZS2_k127_2415136_0	330214.NIDE3493	0.0	1633.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	acrB	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
LZS2_k127_2415136_2	330214.NIDE3494	9.172e-144	466.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
LZS2_k127_2415136_7	1165096.ARWF01000001_gene2086	2.037e-43	166.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,2VRMP@28216|Betaproteobacteria,2KM2U@206350|Nitrosomonadales	206350|Nitrosomonadales	K	RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_2415136_9	216591.BCAM0001A	5.135e-05	49.0	COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,2VXXB@28216|Betaproteobacteria,1K9C3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
LZS2_k127_2415136_1	479434.Sthe_2955	9.412e-185	585.0	COG4941@1|root,COG4941@2|Bacteria,2G84R@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_2415136_6	330214.NIDE3484	2.785e-51	186.0	COG3795@1|root,COG3795@2|Bacteria	2|Bacteria	F	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
LZS2_k127_2415136_3	330214.NIDE1043	2.768e-102	340.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yetK	-	-	-	-	-	-	-	-	-	-	-	EamA
LZS2_k127_2415136_5	330214.NIDE0936	2.412e-73	265.0	COG4585@1|root,COG4585@2|Bacteria,3J12P@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA_3,PAS_9
LZS2_k127_2415136_4	330214.NIDE0935	3.241e-82	278.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
LZS2_k127_2424628_4	55952.BU52_03740	1.486e-31	134.0	2AWE2@1|root,31NA4@2|Bacteria,2GUTW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2424628_1	1214101.BN159_0094	1.355e-88	310.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	RimK
LZS2_k127_2424628_0	1121946.AUAX01000017_gene4921	1.825e-140	473.0	COG1032@1|root,COG1032@2|Bacteria,2HGPR@201174|Actinobacteria,4D9TA@85008|Micromonosporales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
LZS2_k127_2424628_2	402777.KB235903_gene1331	5.002e-76	263.0	COG0225@1|root,COG0225@2|Bacteria,1G4A7@1117|Cyanobacteria,1HEC0@1150|Oscillatoriales	1117|Cyanobacteria	O	Peptide methionine sulfoxide reductase	msrA2	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
LZS2_k127_2424628_3	1267535.KB906767_gene5293	3.542e-55	196.0	COG0492@1|root,COG0492@2|Bacteria,3Y2NX@57723|Acidobacteria	57723|Acidobacteria	O	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
LZS2_k127_2476067_0	330214.NIDE0370	1.318e-126	406.0	COG0056@1|root,COG0056@2|Bacteria,3J0CZ@40117|Nitrospirae	40117|Nitrospirae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
LZS2_k127_2476067_2	330214.NIDE0369	8.993e-62	217.0	COG0712@1|root,COG0712@2|Bacteria,3J1BY@40117|Nitrospirae	40117|Nitrospirae	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
LZS2_k127_2476067_1	330214.NIDE0263	4.076e-107	354.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,HEAT_2
LZS2_k127_2489794_4	1525715.IX54_09680	2.856e-09	58.0	COG0653@1|root,COG3318@1|root,COG0653@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,2U3DY@28211|Alphaproteobacteria,2PWHT@265|Paracoccus	28211|Alphaproteobacteria	U	Uncharacterised protein family (UPF0149)	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
LZS2_k127_2489794_1	1408473.JHXO01000004_gene191	3.046e-39	153.0	COG2606@1|root,COG2606@2|Bacteria,4P3TW@976|Bacteroidetes,2FXVH@200643|Bacteroidia	976|Bacteroidetes	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
LZS2_k127_2489794_0	1121378.KB899728_gene4132	3.586e-151	494.0	COG1249@1|root,COG1249@2|Bacteria,1WI3A@1297|Deinococcus-Thermus	2|Bacteria	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	sthA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
LZS2_k127_2489794_3	686340.Metal_2170	2.899e-15	82.0	293CB@1|root,2ZQUX@2|Bacteria,1PBAC@1224|Proteobacteria,1SU7X@1236|Gammaproteobacteria,1XFU3@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2500662_7	926550.CLDAP_13510	9.169e-08	56.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
LZS2_k127_2500662_6	177437.HRM2_03300	1.322e-12	74.0	COG0296@1|root,COG0296@2|Bacteria,1NIZI@1224|Proteobacteria,42WYM@68525|delta/epsilon subdivisions,2WSNX@28221|Deltaproteobacteria,2MMER@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
LZS2_k127_2500662_5	1121957.ATVL01000009_gene942	2.067e-28	128.0	COG1680@1|root,COG1680@2|Bacteria,4NIG6@976|Bacteroidetes,47QJK@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
LZS2_k127_2500662_1	768710.DesyoDRAFT_1775	2.38e-125	425.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K22318	-	-	-	-	ko00000	-	-	-	B12-binding,Radical_SAM
LZS2_k127_2500662_4	1519464.HY22_04135	3.836e-32	134.0	COG1309@1|root,COG1309@2|Bacteria,1FFPT@1090|Chlorobi	1090|Chlorobi	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
LZS2_k127_2500662_2	1047013.AQSP01000104_gene1418	3.015e-101	344.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
LZS2_k127_2500662_3	1121930.AQXG01000008_gene207	6.019e-88	295.0	COG1136@1|root,COG1136@2|Bacteria,4NFDW@976|Bacteroidetes,1INQS@117747|Sphingobacteriia	976|Bacteroidetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_2500662_0	929703.KE386491_gene1724	8.942e-140	474.0	COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia	976|Bacteroidetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS2_k127_250076_12	330214.NIDE2438	5.766e-31	124.0	COG2905@1|root,COG2905@2|Bacteria,3J0UW@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
LZS2_k127_250076_11	405948.SACE_1012	3.338e-46	185.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4E2RA@85010|Pseudonocardiales	201174|Actinobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
LZS2_k127_250076_10	330214.NIDE3956	1.085e-52	193.0	COG0424@1|root,COG0424@2|Bacteria	2|Bacteria	D	maF-like protein	maf	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944	2.1.1.190	ko:K03215,ko:K06287	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Maf
LZS2_k127_250076_2	330214.NIDE3957	1.724e-141	460.0	COG0042@1|root,COG0042@2|Bacteria	2|Bacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05541	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
LZS2_k127_250076_3	330214.NIDE3958	1.627e-135	447.0	COG3220@1|root,COG3220@2|Bacteria,3J130@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF692)	-	-	-	-	-	-	-	-	-	-	-	-	DUF692
LZS2_k127_250076_8	330214.NIDE3959	7.434e-77	265.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	1.1.1.42,1.3.1.85	ko:K00031,ko:K14446	ko00020,ko00480,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00373,M00740	R00267,R00268,R01899,R09291	RC00001,RC00084,RC00114,RC00626,RC02481,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,GGDEF,PAS_9
LZS2_k127_250076_0	330214.NIDE3960	1.319e-156	504.0	COG1611@1|root,COG1611@2|Bacteria,3J169@40117|Nitrospirae	40117|Nitrospirae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
LZS2_k127_250076_5	330214.NIDE3961	3.152e-129	419.0	COG2404@1|root,COG2404@2|Bacteria,3J12M@40117|Nitrospirae	40117|Nitrospirae	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_250076_6	330214.NIDE3962	3.146e-104	342.0	COG0705@1|root,COG0705@2|Bacteria,3J16E@40117|Nitrospirae	40117|Nitrospirae	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
LZS2_k127_250076_1	330214.NIDE3963	7.345e-154	507.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
LZS2_k127_250076_4	330214.NIDE3964	1.052e-129	424.0	COG0026@1|root,COG0026@2|Bacteria,3J11N@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
LZS2_k127_250076_9	330214.NIDE3965	1.835e-65	229.0	COG0041@1|root,COG0041@2|Bacteria,3J0P8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
LZS2_k127_2553048_7	330214.NIDE0282	3.1e-140	456.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE0282|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2553048_17	330214.NIDE0281	1.896e-43	162.0	COG1734@1|root,COG1734@2|Bacteria,3J0TH@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
LZS2_k127_2553048_9	330214.NIDE0280	1.486e-109	357.0	COG0353@1|root,COG0353@2|Bacteria,3J0KB@40117|Nitrospirae	40117|Nitrospirae	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
LZS2_k127_2553048_16	330214.NIDE0279	2.064e-45	166.0	COG0718@1|root,COG0718@2|Bacteria,3J1EY@40117|Nitrospirae	40117|Nitrospirae	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
LZS2_k127_2553048_2	330214.NIDE0278	3.246e-221	701.0	COG2812@1|root,COG2812@2|Bacteria,3J0DD@40117|Nitrospirae	40117|Nitrospirae	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
LZS2_k127_2553048_3	330214.NIDE0262	3.772e-190	602.0	COG0544@1|root,COG0544@2|Bacteria,3J12E@40117|Nitrospirae	40117|Nitrospirae	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	Trigger_C,Trigger_N
LZS2_k127_2553048_8	330214.NIDE0261	2.454e-119	388.0	COG0740@1|root,COG0740@2|Bacteria,3J0A3@40117|Nitrospirae	40117|Nitrospirae	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
LZS2_k127_2553048_0	330214.NIDE0260	2.825e-250	775.0	COG1219@1|root,COG1219@2|Bacteria,3J0AM@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
LZS2_k127_2553048_13	330214.NIDE0258	1.446e-66	231.0	COG3215@1|root,COG3215@2|Bacteria	2|Bacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ,Response_reg
LZS2_k127_2553048_14	330214.NIDE0257	1.57e-64	225.0	COG3215@1|root,COG3215@2|Bacteria	2|Bacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ,Response_reg
LZS2_k127_2553048_21	330214.NIDE0256	2.232e-11	71.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	cpeZ	-	-	ko:K05386	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_2553048_12	330214.NIDE0255	6.398e-71	248.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
LZS2_k127_2553048_4	330214.NIDE0254	9.349e-181	574.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
LZS2_k127_2553048_10	330214.NIDE0251	1.127e-107	355.0	COG2071@1|root,COG2071@2|Bacteria,3J0PV@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
LZS2_k127_2553048_1	330214.NIDE0250	1.399e-232	728.0	COG0531@1|root,COG0531@2|Bacteria,3J0ZY@40117|Nitrospirae	40117|Nitrospirae	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
LZS2_k127_2553048_5	330214.NIDE0246	3.289e-154	495.0	COG1472@1|root,COG1472@2|Bacteria,3J0MK@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
LZS2_k127_2553048_6	56780.SYN_02170	1.414e-144	474.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2MRFV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
LZS2_k127_2553048_11	330214.NIDE0244	8.528e-100	328.0	COG0602@1|root,COG0602@2|Bacteria,3J0M2@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
LZS2_k127_260218_6	1265313.HRUBRA_02874	6.228e-08	54.0	COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,1JBP6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
LZS2_k127_260218_0	323848.Nmul_A0545	1.38e-124	406.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,37275@32003|Nitrosomonadales	28216|Betaproteobacteria	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
LZS2_k127_260218_2	977880.pRALTA_0453	1.797e-31	128.0	2E1Y1@1|root,32X6X@2|Bacteria,1N67Q@1224|Proteobacteria,2VVJX@28216|Betaproteobacteria,1K8KU@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_260218_5	1499967.BAYZ01000041_gene2340	6.053e-09	64.0	2EH5Q@1|root,33AXM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_260218_4	237368.SCABRO_03672	3.392e-16	84.0	2E0GK@1|root,32W2J@2|Bacteria,2J4RU@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_260218_1	237368.SCABRO_03671	1.784e-45	173.0	29Z27@1|root,30KZN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_260218_3	1121946.AUAX01000014_gene1227	3.386e-17	84.0	COG1476@1|root,COG1476@2|Bacteria,2GQIU@201174|Actinobacteria,4DF0Z@85008|Micromonosporales	201174|Actinobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
LZS2_k127_2628629_2	1382356.JQMP01000003_gene2027	1.36e-55	200.0	COG0412@1|root,COG0412@2|Bacteria,2G9WC@200795|Chloroflexi,27Z94@189775|Thermomicrobia	189775|Thermomicrobia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
LZS2_k127_2628629_0	330214.NIDE1518	2.187e-105	345.0	COG1573@1|root,COG1573@2|Bacteria,3J0MR@40117|Nitrospirae	40117|Nitrospirae	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
LZS2_k127_2628629_3	330214.NIDE0339	2.409e-05	54.0	2989D@1|root,2ZVF0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2638621_1	700598.Niako_2100	3.809e-76	262.0	COG3023@1|root,COG3023@2|Bacteria	2|Bacteria	V	N-Acetylmuramoyl-L-alanine amidase	-	-	3.2.1.3,3.2.1.52,3.5.1.28	ko:K01207,ko:K01447,ko:K11066,ko:K21574	ko00500,ko00520,ko00531,ko01100,ko01501,map00500,map00520,map00531,map01100,map01501	M00628	R00022,R01790,R01791,R04112,R05963,R07809,R07810,R10831	RC00049,RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011	-	GH97	-	Amidase_2,PG_binding_1
LZS2_k127_2638621_4	857087.Metme_3517	7.789e-06	49.0	COG0708@1|root,COG0708@2|Bacteria	2|Bacteria	L	double-stranded DNA 3'-5' exodeoxyribonuclease activity	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
LZS2_k127_2638621_2	330214.NIDE1812	1.696e-23	105.0	2ED2F@1|root,336ZC@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
LZS2_k127_2638621_3	330214.NIDE4295	1.357e-18	87.0	COG1525@1|root,COG1525@2|Bacteria	2|Bacteria	L	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	Excalibur,SNase
LZS2_k127_2638621_0	1121106.JQKB01000029_gene4878	0.0	1041.0	COG3055@1|root,COG5588@1|root,COG3055@2|Bacteria,COG5588@2|Bacteria,1QE0Q@1224|Proteobacteria	1224|Proteobacteria	G	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,Glyoxal_oxid_N,Kelch_1,Kelch_4
LZS2_k127_2647562_0	330214.NIDE4102	9.368e-99	327.0	COG1989@1|root,COG1989@2|Bacteria,3J0SK@40117|Nitrospirae	40117|Nitrospirae	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
LZS2_k127_2647562_3	330214.NIDE4103	2.833e-28	116.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HATPase_c,HisKA,Response_reg
LZS2_k127_2647562_1	330214.NIDE4104	5.872e-92	309.0	COG0566@1|root,COG0566@2|Bacteria,3J0RH@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
LZS2_k127_2647562_2	330214.NIDE4105	4.466e-88	297.0	COG0215@1|root,COG0215@2|Bacteria,3J0CM@40117|Nitrospirae	40117|Nitrospirae	J	DALR_2	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
LZS2_k127_2726822_6	573413.Spirs_1685	4.548e-16	83.0	COG0071@1|root,COG0071@2|Bacteria,2J818@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
LZS2_k127_2726822_7	251221.35213551	1.004e-11	67.0	COG2370@1|root,COG2370@2|Bacteria,1G65K@1117|Cyanobacteria	1117|Cyanobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
LZS2_k127_2726822_3	330214.NIDE0688	3.196e-66	228.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	nikR	GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
LZS2_k127_2726822_5	330214.NIDE0689	4.141e-32	129.0	2AIN5@1|root,3194H@2|Bacteria,3J1DR@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF3842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3842
LZS2_k127_2726822_0	330214.NIDE0690	0.0	1044.0	COG4772@1|root,COG4772@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
LZS2_k127_2726822_2	330214.NIDE0691	2.25e-82	279.0	COG2094@1|root,COG2094@2|Bacteria	2|Bacteria	L	Belongs to the DNA glycosylase MPG family	mpg	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
LZS2_k127_2726822_1	330214.NIDE0694	9.179e-84	280.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,3J117@40117|Nitrospirae	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA
LZS2_k127_2754107_1	330214.NIDE2086	3.565e-214	684.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
LZS2_k127_2754107_0	330214.NIDE2085	3.05e-245	793.0	COG3857@1|root,COG3857@2|Bacteria	2|Bacteria	L	exonuclease activity	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
LZS2_k127_2754107_2	330214.NIDE2084	4.032e-41	153.0	COG0526@1|root,COG0526@2|Bacteria,3J1BP@40117|Nitrospirae	40117|Nitrospirae	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
LZS2_k127_2754107_3	391008.Smal_2679	1.309e-15	88.0	COG3568@1|root,COG3568@2|Bacteria,1N7P6@1224|Proteobacteria,1RXQ1@1236|Gammaproteobacteria,1X6FC@135614|Xanthomonadales	135614|Xanthomonadales	G	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
LZS2_k127_2767673_2	278963.ATWD01000001_gene3094	2.04e-24	104.0	COG5579@1|root,COG5579@2|Bacteria,3Y526@57723|Acidobacteria,2JJJ8@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
LZS2_k127_2767673_0	497964.CfE428DRAFT_3716	8.079e-140	462.0	COG3604@1|root,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	nifA	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Response_reg,Sigma54_activat
LZS2_k127_2767673_1	1463887.KL590004_gene1996	1.169e-71	248.0	COG3217@1|root,COG3217@2|Bacteria	2|Bacteria	S	molybdenum ion binding	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
LZS2_k127_2767673_3	1502850.FG91_02597	6.772e-15	74.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2U17G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
LZS2_k127_2787389_1	330214.NIDE4155	2.093e-183	581.0	293H1@1|root,2ZQZ6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2787389_0	330214.NIDE1890	0.0	1181.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
LZS2_k127_2787389_2	1227266.HMPREF1551_01825	2.415e-07	57.0	COG2020@1|root,COG2020@2|Bacteria,4NPVN@976|Bacteroidetes,1I2QK@117743|Flavobacteriia,1ERUX@1016|Capnocytophaga	976|Bacteroidetes	O	Isoprenylcysteine carboxyl methyltransferase family protein	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
LZS2_k127_2833660_1	1123368.AUIS01000029_gene1290	6.32e-45	168.0	COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,1S4E9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	NMD3
LZS2_k127_2833660_4	1232410.KI421420_gene3178	0.0004679	46.0	2EM0B@1|root,33EPU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_2833660_0	497965.Cyan7822_5298	1.129e-198	633.0	COG0028@1|root,COG0028@2|Bacteria,1G0KQ@1117|Cyanobacteria,3KG17@43988|Cyanothece	1117|Cyanobacteria	EH	Belongs to the TPP enzyme family	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
LZS2_k127_2925188_6	330214.NIDE0302	2.37e-15	78.0	COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
LZS2_k127_2925188_1	330214.NIDE0301	3.568e-91	302.0	COG0663@1|root,COG0663@2|Bacteria,3J121@40117|Nitrospirae	40117|Nitrospirae	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
LZS2_k127_2925188_5	1198452.Jab_2c13890	3.689e-42	160.0	COG0449@1|root,COG0449@2|Bacteria,1RGWX@1224|Proteobacteria,2VW7M@28216|Betaproteobacteria	28216|Betaproteobacteria	M	ORF6N domain	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
LZS2_k127_2925188_4	443143.GM18_3270	4.248e-66	235.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNJE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
LZS2_k127_2925188_0	330214.NIDE0299	3.601e-161	512.0	COG0548@1|root,COG0548@2|Bacteria,3J0H3@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
LZS2_k127_2925188_2	330214.NIDE0298	9.355e-90	297.0	COG1220@1|root,COG1220@2|Bacteria,3J0XE@40117|Nitrospirae	40117|Nitrospirae	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
LZS2_k127_294786_2	330214.NIDE1510	1.035e-118	390.0	COG0750@1|root,COG0750@2|Bacteria,3J0GI@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
LZS2_k127_294786_1	330214.NIDE1511	2.141e-194	613.0	COG0743@1|root,COG0743@2|Bacteria,3J0B0@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
LZS2_k127_294786_5	330214.NIDE1512	2.985e-54	203.0	COG4589@1|root,COG4589@2|Bacteria,3J1FV@40117|Nitrospirae	40117|Nitrospirae	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
LZS2_k127_294786_3	330214.NIDE1513	2.229e-117	385.0	COG0020@1|root,COG0020@2|Bacteria,3J0HJ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
LZS2_k127_294786_0	330214.NIDE1514	2.219e-246	766.0	COG0312@1|root,COG0312@2|Bacteria,3J0F9@40117|Nitrospirae	40117|Nitrospirae	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
LZS2_k127_294786_4	330214.NIDE1515	1.978e-80	274.0	COG0312@1|root,COG0312@2|Bacteria,3J0P7@40117|Nitrospirae	40117|Nitrospirae	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
LZS2_k127_3003556_0	330214.NIDE4242	8.695e-203	640.0	COG1160@1|root,COG1160@2|Bacteria,3J0G3@40117|Nitrospirae	40117|Nitrospirae	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	engA	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
LZS2_k127_3003556_1	330214.NIDE4241	3.319e-92	307.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
LZS2_k127_3027462_1	330214.NIDE1875	4.645e-119	384.0	COG0450@1|root,COG0450@2|Bacteria,3J0T1@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
LZS2_k127_3027462_2	330214.NIDE1874	6.909e-52	186.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,Pentapeptide,TIR_2,WD40
LZS2_k127_3027462_0	330214.NIDE1873	5.094e-246	790.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
LZS2_k127_3123958_1	379066.GAU_0073	7.042e-25	107.0	COG1669@1|root,COG1669@2|Bacteria,1ZUYI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
LZS2_k127_3123958_0	622637.KE124774_gene1440	3.871e-55	202.0	COG2067@1|root,COG2067@2|Bacteria,1R172@1224|Proteobacteria	1224|Proteobacteria	I	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
LZS2_k127_3148789_2	338969.Rfer_4026	6.258e-18	87.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VRNF@28216|Betaproteobacteria,4AE82@80864|Comamonadaceae	28216|Betaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
LZS2_k127_3148789_0	1173024.KI912149_gene5854	3.444e-177	571.0	COG0457@1|root,COG0457@2|Bacteria,1GDHI@1117|Cyanobacteria	1117|Cyanobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3148789_3	1123508.JH636443_gene4626	1.696e-14	81.0	2EH96@1|root,33B10@2|Bacteria,2J3YR@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3148789_4	1041146.ATZB01000023_gene2692	0.0006183	48.0	COG2823@1|root,COG2823@2|Bacteria,1RA8T@1224|Proteobacteria,2U5G7@28211|Alphaproteobacteria,4BE8Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
LZS2_k127_3148789_1	330214.NIDE4341	7.552e-118	387.0	COG1249@1|root,COG1249@2|Bacteria,3J11P@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
LZS2_k127_3182738_0	330214.NIDE2203	8.527e-222	692.0	COG0364@1|root,COG0364@2|Bacteria,3J0XD@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
LZS2_k127_3182738_2	330214.NIDE2204	2.825e-166	526.0	COG1023@1|root,COG1023@2|Bacteria	2|Bacteria	G	D-gluconate metabolic process	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
LZS2_k127_3182738_4	330214.NIDE2205	6.407e-104	343.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K17882	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	KNTase_C,NTP_transf_2
LZS2_k127_3182738_3	330214.NIDE2207	2.377e-146	471.0	COG2008@1|root,COG2008@2|Bacteria	2|Bacteria	E	L-allo-threonine aldolase activity	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
LZS2_k127_3182738_1	330214.NIDE2208	1.901e-193	612.0	COG3202@1|root,COG3202@2|Bacteria	2|Bacteria	C	ATP:ADP antiporter activity	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
LZS2_k127_319518_6	330214.NIDE4111	1.71e-89	297.0	COG0527@1|root,COG0527@2|Bacteria,3J0AZ@40117|Nitrospirae	40117|Nitrospirae	E	ACT domain	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
LZS2_k127_319518_4	330214.NIDE4112	1.591e-150	486.0	COG3635@1|root,COG3635@2|Bacteria,3J0YA@40117|Nitrospirae	40117|Nitrospirae	G	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
LZS2_k127_319518_3	330214.NIDE4113	3.828e-184	580.0	COG0498@1|root,COG0498@2|Bacteria,3J0FI@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC2	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
LZS2_k127_319518_1	330214.NIDE4114	1.502e-214	672.0	COG0440@1|root,COG0460@1|root,COG0440@2|Bacteria,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae	40117|Nitrospirae	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
LZS2_k127_319518_0	330214.NIDE4115	6.923e-240	745.0	COG0436@1|root,COG0436@2|Bacteria,3J0ED@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_319518_5	330214.NIDE4117	4.55e-119	385.0	COG0854@1|root,COG0854@2|Bacteria,3J0KZ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
LZS2_k127_319518_2	330214.NIDE4119	1.081e-210	666.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,3J0J1@40117|Nitrospirae	40117|Nitrospirae	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	-	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
LZS2_k127_319518_8	330214.NIDE4120	1.982e-33	137.0	COG0802@1|root,COG0802@2|Bacteria,3J1AZ@40117|Nitrospirae	40117|Nitrospirae	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
LZS2_k127_319518_7	330214.NIDE4122	2.655e-67	235.0	COG0249@1|root,COG0249@2|Bacteria,3J0CE@40117|Nitrospirae	40117|Nitrospirae	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
LZS2_k127_319846_0	330214.NIDE0351	0.0	1037.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	MA20_43810	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS2_k127_319846_1	330214.NIDE0350	1.734e-93	313.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_319846_2	330214.NIDE0349	4.871e-77	265.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
LZS2_k127_319846_3	330214.NIDE0347	7.441e-53	198.0	COG4715@1|root,COG4715@2|Bacteria	2|Bacteria	S	zinc ion binding	yehQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	SWIM
LZS2_k127_321326_3	330214.NIDE4271	1.025e-226	708.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	nla6	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_321326_4	330214.NIDE4272	9.943e-221	693.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	pilS	-	2.7.13.3	ko:K02668,ko:K10942	ko02020,ko05111,map02020,map05111	M00501,M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
LZS2_k127_321326_18	330214.NIDE3879	3.156e-59	209.0	COG2010@1|root,COG2010@2|Bacteria,3J17C@40117|Nitrospirae	40117|Nitrospirae	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
LZS2_k127_321326_17	330214.NIDE3881	3.3e-62	215.0	COG1553@1|root,COG1553@2|Bacteria	2|Bacteria	P	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE	-	-	-	ko:K06039,ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
LZS2_k127_321326_13	330214.NIDE3832	5.802e-67	233.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460,F5_F8_type_C
LZS2_k127_321326_2	330214.NIDE3882	1.423e-243	766.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_321326_16	330214.NIDE3885	9.828e-64	221.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	ycaO	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC,YcaO
LZS2_k127_321326_9	330214.NIDE3886	7.625e-111	364.0	COG3258@1|root,COG3258@2|Bacteria,3J12T@40117|Nitrospirae	40117|Nitrospirae	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.8.2.2	ko:K19713	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3
LZS2_k127_321326_22	330214.NIDE3893	1.147e-23	107.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_321326_0	330214.NIDE1742	0.0	2330.0	COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria	2|Bacteria	Q	D-alanine [D-alanyl carrier protein] ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,MbtH,PP-binding,Thioesterase
LZS2_k127_321326_5	330214.NIDE1743	2.555e-166	539.0	COG4615@1|root,COG4615@2|Bacteria	2|Bacteria	V	microcin transport	-	-	-	ko:K06160	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.113.2	-	-	ABC_membrane,ABC_tran
LZS2_k127_321326_20	1173021.ALWA01000031_gene2786	5.7e-38	153.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	hetI	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
LZS2_k127_321326_15	330214.NIDE3895	7.782e-65	224.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
LZS2_k127_321326_14	330214.NIDE3905	5.069e-65	225.0	COG1814@1|root,COG1814@2|Bacteria	2|Bacteria	S	cellular manganese ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
LZS2_k127_321326_23	330214.NIDE3893	3.328e-23	103.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_321326_19	330214.NIDE3906	3.574e-48	181.0	COG3218@1|root,COG3218@2|Bacteria	2|Bacteria	Q	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
LZS2_k127_321326_10	330214.NIDE3907	8.676e-110	365.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	iamC	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
LZS2_k127_321326_8	330214.NIDE3908	1.241e-125	408.0	COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae	2|Bacteria	Q	ABC transporter	iamA	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
LZS2_k127_321326_7	330214.NIDE3909	1.157e-141	458.0	COG0767@1|root,COG0767@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, permease component	iamB	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
LZS2_k127_321326_1	330214.NIDE2929	1.833e-276	860.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	2|Bacteria	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	3.4.21.53	ko:K03798,ko:K04076,ko:K13525,ko:K17681	ko04141,ko05134,map04141,map05134	M00400,M00403,M00742	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03019,ko03029,ko03110,ko04131,ko04147	3.A.16.1	-	-	AAA,FtsH_ext,Peptidase_M41
LZS2_k127_321326_11	330214.NIDE3910	1.624e-77	270.0	COG3170@1|root,COG3170@2|Bacteria,3J1CW@40117|Nitrospirae	40117|Nitrospirae	NU	Protein of unknown function (DUF1207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1207
LZS2_k127_321326_6	479434.Sthe_1967	2.197e-143	467.0	COG3004@1|root,COG3004@2|Bacteria,2G7ZG@200795|Chloroflexi	200795|Chloroflexi	P	) H( ) antiporter that extrudes sodium in exchange for external protons	-	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
LZS2_k127_321326_12	1255043.TVNIR_1112	3.344e-68	233.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
LZS2_k127_3232166_1	330214.NIDE0238	3.664e-112	392.0	COG1198@1|root,COG1198@2|Bacteria,3J0MZ@40117|Nitrospirae	40117|Nitrospirae	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
LZS2_k127_3232166_0	330214.NIDE0237	2.185e-118	400.0	COG1360@1|root,COG1360@2|Bacteria	2|Bacteria	N	Flagellar Motor Protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
LZS2_k127_3232166_2	330214.NIDE0236	1.49e-64	222.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
LZS2_k127_3232166_3	330214.NIDE0235	7.684e-29	117.0	COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
LZS2_k127_3235251_0	671143.DAMO_0410	1.812e-138	448.0	COG2060@1|root,COG2060@2|Bacteria,2NP13@2323|unclassified Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717	KdpA
LZS2_k127_3235251_1	330214.NIDE4278	1.399e-88	298.0	2DC00@1|root,2ZC4V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3235251_4	1487953.JMKF01000021_gene2217	1.721e-14	79.0	COG5428@1|root,COG5428@2|Bacteria,1GB4P@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
LZS2_k127_3235251_2	1348657.M622_19055	6.99e-55	196.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria,2KWA9@206389|Rhodocyclales	206389|Rhodocyclales	L	N-6 DNA Methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
LZS2_k127_323815_2	330214.NIDE4155	3.477e-11	64.0	293H1@1|root,2ZQZ6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3311735_1	765913.ThidrDRAFT_0365	1.926e-202	640.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,1WW9T@135613|Chromatiales	135613|Chromatiales	P	PFAM Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
LZS2_k127_3311735_4	344747.PM8797T_19455	3.14e-05	48.0	COG0659@1|root,COG0659@2|Bacteria,2IY7T@203682|Planctomycetes	203682|Planctomycetes	P	COG0659 Sulfate permease and related transporters (MFS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
LZS2_k127_3311735_3	330214.NIDE4385	1.043e-46	170.0	COG5609@1|root,COG5609@2|Bacteria,3J180@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized conserved protein (DUF2294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2294
LZS2_k127_3311735_0	330214.NIDE4384	1.457e-249	777.0	COG0397@1|root,COG0397@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, YdiU/UPF0061 family	ydiU	-	-	ko:K08997	-	-	-	-	ko00000	-	-	-	UPF0061
LZS2_k127_3311735_2	330214.NIDE4382	1.834e-84	284.0	COG0400@1|root,COG0400@2|Bacteria,3J1DU@40117|Nitrospirae	40117|Nitrospirae	S	Alpha/beta hydrolase family	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
LZS2_k127_3361248_5	330214.NIDE1294	6.534e-20	89.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
LZS2_k127_3361248_7	1122971.BAME01000045_gene3896	5.418e-05	46.0	293V0@1|root,2ZRA7@2|Bacteria,4P8QC@976|Bacteroidetes,2FVS2@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3361248_0	330214.NIDE1291	0.0	1060.0	COG0210@1|root,COG0210@2|Bacteria,3J0VX@40117|Nitrospirae	40117|Nitrospirae	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
LZS2_k127_3361248_6	429009.Adeg_1354	1.137e-15	81.0	COG4634@1|root,COG4634@2|Bacteria,1VXGB@1239|Firmicutes,251NY@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
LZS2_k127_3361248_3	103690.17135379	4.092e-24	111.0	COG2442@1|root,COG2442@2|Bacteria,1G8FX@1117|Cyanobacteria,1HPIE@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
LZS2_k127_3361248_4	1403819.BATR01000141_gene4926	2.661e-23	106.0	2DMJE@1|root,32RYR@2|Bacteria,46W46@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
LZS2_k127_3361248_1	743299.Acife_0301	8.018e-202	636.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,2NDFW@225057|Acidithiobacillales	225057|Acidithiobacillales	L	DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
LZS2_k127_3373199_20	1266925.JHVX01000003_gene547	3.917e-39	151.0	2C8FN@1|root,2ZBER@2|Bacteria,1RK02@1224|Proteobacteria,2WG0U@28216|Betaproteobacteria,372NF@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3373199_13	330214.NIDE3764	3.762e-89	302.0	28PNA@1|root,2ZCB3@2|Bacteria	2|Bacteria	S	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
LZS2_k127_3373199_26	1396141.BATP01000049_gene3483	5.796e-05	52.0	COG3779@1|root,COG3779@2|Bacteria,46X04@74201|Verrucomicrobia,2IW8T@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Uncharacterized protein conserved in bacteria (DUF2314)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2314
LZS2_k127_3373199_2	1121406.JAEX01000002_gene1126	5.927e-191	608.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
LZS2_k127_3373199_15	497965.Cyan7822_3778	6.837e-85	291.0	COG0500@1|root,COG2226@2|Bacteria,1GEHX@1117|Cyanobacteria,3KIZ7@43988|Cyanothece	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
LZS2_k127_3373199_16	330214.NIDE2730	2.141e-70	240.0	COG0105@1|root,COG0105@2|Bacteria,3J0PH@40117|Nitrospirae	40117|Nitrospirae	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
LZS2_k127_3373199_18	330214.NIDE2728	5.638e-58	205.0	COG0509@1|root,COG0509@2|Bacteria,3J0SD@40117|Nitrospirae	40117|Nitrospirae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
LZS2_k127_3373199_24	592015.HMPREF1705_00246	9.9e-12	72.0	COG1555@1|root,COG1555@2|Bacteria,3TB6C@508458|Synergistetes	508458|Synergistetes	L	TIGRFAM competence protein ComEA	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
LZS2_k127_3373199_1	330214.NIDE2725	2.492e-201	634.0	COG0162@1|root,COG0162@2|Bacteria,3J0FX@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
LZS2_k127_3373199_22	330214.NIDE2677	1.155e-20	92.0	COG0227@1|root,COG0227@2|Bacteria,3J0VJ@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
LZS2_k127_3373199_6	330214.NIDE2674	4.791e-120	397.0	COG0614@1|root,COG0614@2|Bacteria,3J173@40117|Nitrospirae	40117|Nitrospirae	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
LZS2_k127_3373199_4	330214.NIDE2673	2.732e-141	459.0	COG0609@1|root,COG0609@2|Bacteria,3J11Y@40117|Nitrospirae	40117|Nitrospirae	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
LZS2_k127_3373199_9	330214.NIDE2672	5.415e-102	349.0	COG1120@1|root,COG1120@2|Bacteria,3J14U@40117|Nitrospirae	40117|Nitrospirae	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
LZS2_k127_3373199_14	1132442.KB889752_gene1215	1.04e-88	299.0	COG0388@1|root,COG0388@2|Bacteria,1V5MI@1239|Firmicutes,4IK6D@91061|Bacilli,1ZFCI@1386|Bacillus	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
LZS2_k127_3373199_0	330214.NIDE2671	1.016e-230	734.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
LZS2_k127_3373199_23	330214.NIDE2670	1.956e-14	74.0	COG1797@1|root,COG1797@2|Bacteria,3J0HM@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	-	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	CbiA,GATase_3
LZS2_k127_3373199_8	330214.NIDE2667	4.699e-104	343.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	bluB	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016491,GO:0016705,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.13.11.79,2.4.2.21	ko:K00768,ko:K04719	ko00740,ko00860,ko01100,map00740,map00860,map01100	M00122	R04148,R09083	RC00033,RC00063,RC00435,RC02413	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT,Nitroreductase
LZS2_k127_3373199_10	330214.NIDE2666	1.797e-95	316.0	COG2096@1|root,COG2096@2|Bacteria	2|Bacteria	S	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.2.1.88,1.5.5.2,2.5.1.17	ko:K00798,ko:K13821	ko00250,ko00330,ko00860,ko01100,ko01110,ko01130,map00250,map00330,map00860,map01100,map01110,map01130	M00122	R00245,R00707,R00708,R01253,R01492,R04444,R04445,R05051,R05220,R07268	RC00080,RC00083,RC00216,RC00242,RC00255,RC00533	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	Cob_adeno_trans
LZS2_k127_3373199_19	330214.NIDE2665	4.554e-52	190.0	COG2087@1|root,COG2087@2|Bacteria,3J0UG@40117|Nitrospirae	40117|Nitrospirae	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	-	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
LZS2_k127_3373199_3	330214.NIDE2664	7.981e-165	525.0	COG2038@1|root,COG2038@2|Bacteria,3J0C9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
LZS2_k127_3373199_12	330214.NIDE2663	2.177e-93	312.0	COG0368@1|root,COG0368@2|Bacteria,3J0VC@40117|Nitrospirae	40117|Nitrospirae	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
LZS2_k127_3373199_11	330214.NIDE2662	6.766e-95	328.0	COG1270@1|root,COG1270@2|Bacteria,3J0K4@40117|Nitrospirae	40117|Nitrospirae	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cbiB	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
LZS2_k127_3373199_7	330214.NIDE2661	1.121e-118	392.0	COG0079@1|root,COG0079@2|Bacteria,3J138@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
LZS2_k127_3373199_17	330214.NIDE2660	1.314e-61	220.0	COG1865@1|root,COG1865@2|Bacteria	2|Bacteria	HP	Adenosylcobinamide amidohydrolase	cbiZ	-	2.7.1.156,2.7.7.62,3.6.3.34	ko:K02013,ko:K02231	ko00860,ko01100,ko02010,map00860,map01100,map02010	M00122,M00240	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran,CbiZ
LZS2_k127_3373199_5	404380.Gbem_3539	2.15e-133	442.0	COG1010@1|root,COG1492@1|root,COG1010@2|Bacteria,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2WJ22@28221|Deltaproteobacteria,43S29@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,Aminotran_1_2,CbiA,GATase_3,TP_methylase
LZS2_k127_3373199_27	330214.NIDE2658	0.0002036	47.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
LZS2_k127_3376680_0	443143.GM18_4261	2.098e-31	131.0	COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,42U4T@68525|delta/epsilon subdivisions,2WQ5B@28221|Deltaproteobacteria,43V1N@69541|Desulfuromonadales	28221|Deltaproteobacteria	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
LZS2_k127_3402884_7	330214.NIDE2467	9.289e-96	315.0	COG0231@1|root,COG0231@2|Bacteria,3J0JC@40117|Nitrospirae	40117|Nitrospirae	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
LZS2_k127_3402884_11	330214.NIDE2468	9.862e-53	192.0	COG0511@1|root,COG0511@2|Bacteria,3J0PI@40117|Nitrospirae	40117|Nitrospirae	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
LZS2_k127_3402884_0	330214.NIDE2469	1.372e-248	772.0	COG0439@1|root,COG0439@2|Bacteria,3J0AJ@40117|Nitrospirae	40117|Nitrospirae	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
LZS2_k127_3402884_4	330214.NIDE1082	2.08e-142	463.0	COG0845@1|root,COG0845@2|Bacteria,3J0HQ@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
LZS2_k127_3402884_5	330214.NIDE1083	1.554e-106	349.0	COG1136@1|root,COG1136@2|Bacteria,3J10N@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_3402884_2	330214.NIDE1084	8.484e-192	605.0	COG0577@1|root,COG0577@2|Bacteria,3J0EW@40117|Nitrospirae	40117|Nitrospirae	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS2_k127_3402884_6	330214.NIDE1085	3.861e-102	347.0	COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
LZS2_k127_3402884_12	330214.NIDE1086	1.405e-45	174.0	COG4570@1|root,COG4570@2|Bacteria	2|Bacteria	L	crossover junction endodeoxyribonuclease activity	rusA	-	3.1.22.4	ko:K01160	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	RusA
LZS2_k127_3402884_10	330214.NIDE1087	4.259e-73	248.0	COG2001@1|root,COG2001@2|Bacteria,3J0VQ@40117|Nitrospirae	40117|Nitrospirae	K	MraZ protein, putative antitoxin-like	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
LZS2_k127_3402884_15	330214.NIDE2346	1.375e-10	63.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
LZS2_k127_3402884_13	330214.NIDE1088	1.881e-27	116.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
LZS2_k127_3402884_9	330214.NIDE1089	7.494e-76	264.0	COG1040@1|root,COG1040@2|Bacteria,3J19P@40117|Nitrospirae	40117|Nitrospirae	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
LZS2_k127_3402884_8	330214.NIDE1090	4.315e-87	293.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_3402884_3	330214.NIDE1091	2.863e-155	496.0	COG0167@1|root,COG0167@2|Bacteria,3J145@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.98.1	ko:K00226,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
LZS2_k127_3402884_14	330214.NIDE1093	2.444e-24	106.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	AroM,GerE
LZS2_k127_3402884_1	330214.NIDE1094	2.355e-228	731.0	COG0577@1|root,COG0577@2|Bacteria,3J0Z3@40117|Nitrospirae	40117|Nitrospirae	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS2_k127_3418638_2	330214.NIDE2411	1.072e-35	140.0	COG0457@1|root,COG3267@1|root,COG0457@2|Bacteria,COG3267@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
LZS2_k127_3418638_1	330214.NIDE2414	1.106e-38	151.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
LZS2_k127_3418638_0	697281.Mahau_1366	1.582e-65	232.0	COG0125@1|root,COG0125@2|Bacteria,1V0EA@1239|Firmicutes,24AIX@186801|Clostridia,42I1F@68295|Thermoanaerobacterales	186801|Clostridia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
LZS2_k127_3440002_0	335283.Neut_0181	0.0	1361.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,374K2@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sterile alpha motif.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1
LZS2_k127_3440002_1	228410.NE0091	0.0	1015.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ9H@28216|Betaproteobacteria,3722H@32003|Nitrosomonadales	28216|Betaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,Usp
LZS2_k127_3440002_25	1366050.N234_22550	4.174e-12	72.0	COG0693@1|root,COG0693@2|Bacteria,1MVTT@1224|Proteobacteria,2VKUH@28216|Betaproteobacteria,1K23D@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM ThiJ PfpI domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
LZS2_k127_3440002_22	866536.Belba_2766	1.055e-21	100.0	COG3631@1|root,COG3631@2|Bacteria,4NTDK@976|Bacteroidetes,47X6T@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
LZS2_k127_3440002_13	330214.NIDE0012	3.597e-76	259.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	fosB2	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
LZS2_k127_3440002_12	330214.NIDE0011	3.289e-79	270.0	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
LZS2_k127_3440002_10	330214.NIDE0010	9.487e-116	379.0	COG1741@1|root,COG1741@2|Bacteria,3J125@40117|Nitrospirae	40117|Nitrospirae	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
LZS2_k127_3440002_8	330214.NIDE0009	2.237e-125	407.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
LZS2_k127_3440002_21	977880.pRALTA_0622	4.226e-28	118.0	COG3744@1|root,COG3744@2|Bacteria,1NA89@1224|Proteobacteria,2VUYN@28216|Betaproteobacteria,1KFTZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS2_k127_3440002_24	640511.BC1002_6129	4.347e-20	92.0	COG4118@1|root,COG4118@2|Bacteria,1N7BG@1224|Proteobacteria,2VY0B@28216|Betaproteobacteria,1K9M1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
LZS2_k127_3440002_18	228410.NE0900	7.731e-38	147.0	2C8BN@1|root,32RKS@2|Bacteria,1N56Z@1224|Proteobacteria,2W56V@28216|Betaproteobacteria,373EQ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
LZS2_k127_3440002_23	330214.NIDE3568	1.2e-20	96.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	yggU	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
LZS2_k127_3440002_6	330214.NIDE3569	2.715e-138	443.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	norQ	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
LZS2_k127_3440002_2	330214.NIDE3570	1.5e-323	1008.0	COG2203@1|root,COG3437@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
LZS2_k127_3440002_7	330214.NIDE3571	1.564e-132	440.0	COG0727@1|root,COG4866@1|root,COG0727@2|Bacteria,COG4866@2|Bacteria	2|Bacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163,ko:K06940	-	-	-	-	ko00000	-	-	-	Acetyltransf_9,CxxCxxCC,DUF2156
LZS2_k127_3440002_5	330214.NIDE3572	7.525e-181	578.0	28MGX@1|root,2ZATZ@2|Bacteria,3J0YU@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3440002_20	330214.NIDE3573	1.804e-29	120.0	COG0625@1|root,COG0625@2|Bacteria	2|Bacteria	O	glutathione transferase activity	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
LZS2_k127_3440002_3	330214.NIDE3574	3.558e-210	658.0	COG1509@1|root,COG1509@2|Bacteria,3J0W3@40117|Nitrospirae	40117|Nitrospirae	C	Lysine-2,3-aminomutase	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	LAM_C,Radical_SAM
LZS2_k127_3440002_4	330214.NIDE3575	3.557e-200	629.0	COG0717@1|root,COG0717@2|Bacteria,3J0WG@40117|Nitrospirae	40117|Nitrospirae	F	2'-deoxycytidine 5'-triphosphate deaminase (DCD)	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
LZS2_k127_3440002_14	330214.NIDE3577	4.62e-76	264.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	3.4.14.13	ko:K20742	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Glycos_transf_2
LZS2_k127_3440002_11	330214.NIDE3579	1.235e-94	316.0	COG3222@1|root,COG3222@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
LZS2_k127_3440002_9	330214.NIDE3580	2.747e-122	397.0	COG1028@1|root,COG1028@2|Bacteria	330214.NIDE3580|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
LZS2_k127_3447981_4	330214.NIDE2927	2.047e-146	466.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3J0AI@40117|Nitrospirae	40117|Nitrospirae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
LZS2_k127_3447981_5	330214.NIDE2926	2.232e-127	417.0	COG2812@1|root,COG2812@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
LZS2_k127_3447981_7	330214.NIDE2924	3.794e-65	229.0	COG0125@1|root,COG0125@2|Bacteria,3J0NI@40117|Nitrospirae	40117|Nitrospirae	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
LZS2_k127_3447981_6	330214.NIDE2923	3.062e-100	331.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
LZS2_k127_3447981_3	330214.NIDE2922	7.098e-192	613.0	COG1207@1|root,COG1207@2|Bacteria,3J0CG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
LZS2_k127_3447981_2	204669.Acid345_0997	8.003e-225	712.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
LZS2_k127_3447981_10	330214.NIDE2920	1.441e-25	108.0	COG0721@1|root,COG0721@2|Bacteria,3J0V3@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
LZS2_k127_3447981_8	330214.NIDE2919	2.82e-57	200.0	COG0853@1|root,COG0853@2|Bacteria,3J0Q2@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
LZS2_k127_3447981_0	330214.NIDE2918	6.05e-248	773.0	COG0154@1|root,COG0154@2|Bacteria,3J0AA@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
LZS2_k127_3447981_9	330214.NIDE2917	4.953e-46	169.0	COG4768@1|root,COG4768@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF948)	WQ51_05790	-	-	-	-	-	-	-	-	-	-	-	DUF948
LZS2_k127_3447981_1	330214.NIDE2915	6.341e-243	757.0	COG0064@1|root,COG0064@2|Bacteria,3J0FK@40117|Nitrospirae	40117|Nitrospirae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
LZS2_k127_3447981_11	1207063.P24_04884	1.871e-09	59.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,2JQAU@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
LZS2_k127_3450719_6	296591.Bpro_3196	1.177e-10	62.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,4ADVR@80864|Comamonadaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
LZS2_k127_3450719_3	330214.NIDE1230	1.646e-54	194.0	COG1610@1|root,COG1610@2|Bacteria,3J1F3@40117|Nitrospirae	40117|Nitrospirae	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
LZS2_k127_3450719_2	330214.NIDE1229	3.763e-86	292.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K03413,ko:K07315	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021	-	-	-	GGDEF,HATPase_c,HATPase_c_2,HisKA,Response_reg
LZS2_k127_3450719_1	330214.NIDE1228	2.57e-160	512.0	COG2199@1|root,COG3706@2|Bacteria,3J188@40117|Nitrospirae	40117|Nitrospirae	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
LZS2_k127_3450719_0	330214.NIDE1227	6.609e-198	644.0	COG0642@1|root,COG0784@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	2.7.13.3	ko:K20973	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3
LZS2_k127_3450719_4	330214.NIDE1226	6.438e-19	91.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
LZS2_k127_3450719_5	1437448.AZRT01000044_gene4952	7.428e-15	85.0	COG1961@1|root,COG1961@2|Bacteria,1MV0C@1224|Proteobacteria,2TTJT@28211|Alphaproteobacteria,1J35W@118882|Brucellaceae	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
LZS2_k127_3479461_0	1288494.EBAPG3_23840	4.28e-246	779.0	COG1276@1|root,COG2010@1|root,COG1276@2|Bacteria,COG2010@2|Bacteria,1RG2C@1224|Proteobacteria,2WEJ9@28216|Betaproteobacteria,372HR@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Copper resistance D	-	-	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	AhpC-TSA,CopD,Cytochrome_CBB3
LZS2_k127_3479461_20	1288494.EBAPG3_23830	5.867e-43	161.0	COG2372@1|root,COG2372@2|Bacteria,1N8SS@1224|Proteobacteria,2VXMG@28216|Betaproteobacteria,373J0@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Copper resistance protein CopC	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
LZS2_k127_3479461_21	261292.Nit79A3_0475	8.047e-43	164.0	2E6CY@1|root,3310K@2|Bacteria,1NFYR@1224|Proteobacteria,2WBBD@28216|Betaproteobacteria,372S0@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3479461_13	1266925.JHVX01000022_gene1759	3.367e-69	241.0	2E6CY@1|root,3310K@2|Bacteria,1NFYR@1224|Proteobacteria,2WBBD@28216|Betaproteobacteria,372S0@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3479461_17	1266925.JHVX01000022_gene1758	2.343e-60	215.0	2AHBR@1|root,317ND@2|Bacteria,1PZ06@1224|Proteobacteria,2WE47@28216|Betaproteobacteria,3732U@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3479461_9	330214.NIDE1021	3.075e-85	284.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
LZS2_k127_3479461_15	330214.NIDE1022	2.284e-68	235.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
LZS2_k127_3479461_6	1122603.ATVI01000006_gene805	1.543e-138	460.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	shp	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C,DUF1924
LZS2_k127_3479461_19	330214.NIDE1024	1.025e-44	171.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,HD,HD_5
LZS2_k127_3479461_8	330214.NIDE1026	2.415e-92	308.0	COG3901@1|root,COG3901@2|Bacteria	2|Bacteria	CK	FMN binding	nosR	-	-	ko:K19339,ko:K19343	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind,Fer4_5
LZS2_k127_3479461_2	330214.NIDE1028	2.439e-217	684.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K12065	-	-	-	-	ko00000,ko02044	3.A.7.11.1	-	-	Porin_O_P
LZS2_k127_3479461_24	1297742.A176_03639	0.0001065	48.0	2BR48@1|root,32K27@2|Bacteria,1Q2KM@1224|Proteobacteria,43878@68525|delta/epsilon subdivisions,2X3H6@28221|Deltaproteobacteria,2YW2M@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3479461_7	330214.NIDE1029	1.333e-115	383.0	COG1477@1|root,COG1477@2|Bacteria	2|Bacteria	H	protein flavinylation	nosX	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
LZS2_k127_3479461_23	545694.TREPR_1131	1.689e-05	56.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	CarbopepD_reg_2,TonB_C
LZS2_k127_3479461_22	387092.NIS_1423	4.866e-19	91.0	COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2YQ7R@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
LZS2_k127_3479461_16	330214.NIDE1033	3.989e-67	230.0	COG0811@1|root,COG0811@2|Bacteria	2|Bacteria	U	bacteriocin transport	exbB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
LZS2_k127_3479461_5	330214.NIDE1034	3.669e-154	496.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	potA	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
LZS2_k127_3479461_1	330214.NIDE1035	1.17e-222	702.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	sfuB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
LZS2_k127_3479461_3	330214.NIDE1036	5.253e-158	504.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	fbpA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	iJN678.sufA	SBP_bac_6,SBP_bac_8
LZS2_k127_3479461_11	330214.NIDE1037	1.483e-80	269.0	COG0735@1|root,COG0735@2|Bacteria,3J0UN@40117|Nitrospirae	40117|Nitrospirae	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
LZS2_k127_3479461_4	309807.SRU_2485	4.929e-156	508.0	COG2317@1|root,COG2317@2|Bacteria,4NK5Q@976|Bacteroidetes,1FISH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
LZS2_k127_3479461_14	330214.NIDE1042	8.571e-69	239.0	COG4122@1|root,COG4122@2|Bacteria,3J1C3@40117|Nitrospirae	40117|Nitrospirae	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3490110_38	1087481.AGFX01000047_gene2047	7.483e-56	210.0	COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,4HEJ1@91061|Bacilli,26TD7@186822|Paenibacillaceae	91061|Bacilli	S	glycosyl transferase family 2	galnac-T15	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_7C,Glycos_transf_2
LZS2_k127_3490110_54	696281.Desru_1117	3.538e-08	63.0	COG0438@1|root,COG0500@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2226@2|Bacteria,1V06G@1239|Firmicutes,247WU@186801|Clostridia	186801|Clostridia	H	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,Methyltransf_23
LZS2_k127_3490110_47	1122218.KB893653_gene251	5.17e-34	148.0	COG2244@1|root,COG2244@2|Bacteria,1MUMD@1224|Proteobacteria,2TTZ8@28211|Alphaproteobacteria,1JTFF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Polysaccharide biosynthesis protein	pssL	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3,Polysacc_synt_C
LZS2_k127_3490110_46	192952.MM_1126	2.81e-35	150.0	COG0438@1|root,arCOG01410@2157|Archaea,2XV5R@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
LZS2_k127_3490110_41	269797.Mbar_A1128	6.683e-48	187.0	COG0438@1|root,arCOG01410@2157|Archaea,2XV5R@28890|Euryarchaeota,2NBP5@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS2_k127_3490110_26	237368.SCABRO_01330	5.91e-85	298.0	COG3307@1|root,COG3307@2|Bacteria,2J4UI@203682|Planctomycetes	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K02847,ko:K13009	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
LZS2_k127_3490110_13	237368.SCABRO_01328	1.869e-140	471.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2IZZC@203682|Planctomycetes	203682|Planctomycetes	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31
LZS2_k127_3490110_52	1273103.NM10_12133	1.354e-09	68.0	COG1596@1|root,COG1596@2|Bacteria,1V7F2@1239|Firmicutes,4H4S7@909932|Negativicutes	909932|Negativicutes	M	export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
LZS2_k127_3490110_35	330214.NIDE2649	5.378e-58	213.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
LZS2_k127_3490110_7	330214.NIDE2734	3.574e-195	638.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3J0VB@40117|Nitrospirae	40117|Nitrospirae	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,Lactamase_B
LZS2_k127_3490110_4	330214.NIDE2735	6.926e-243	755.0	COG1109@1|root,COG1109@2|Bacteria,3J0E7@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
LZS2_k127_3490110_27	330214.NIDE2736	7.229e-85	290.0	COG0294@1|root,COG0294@2|Bacteria,3J0NS@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
LZS2_k127_3490110_1	330214.NIDE2737	0.0	1097.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	40117|Nitrospirae	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
LZS2_k127_3490110_28	330214.NIDE2738	1.517e-84	283.0	COG0634@1|root,COG0634@2|Bacteria,3J0NZ@40117|Nitrospirae	40117|Nitrospirae	F	Phosphoribosyl transferase domain	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
LZS2_k127_3490110_24	330214.NIDE2739	4.511e-100	344.0	COG0037@1|root,COG0037@2|Bacteria,3J0SX@40117|Nitrospirae	40117|Nitrospirae	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
LZS2_k127_3490110_22	330214.NIDE2740	2.125e-109	362.0	COG0196@1|root,COG0196@2|Bacteria,3J0KY@40117|Nitrospirae	40117|Nitrospirae	H	Riboflavin kinase	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
LZS2_k127_3490110_8	330214.NIDE2741	2.133e-169	535.0	COG0113@1|root,COG0113@2|Bacteria,3J0DV@40117|Nitrospirae	40117|Nitrospirae	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
LZS2_k127_3490110_34	330214.NIDE2742	1.961e-62	216.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	opuCA	-	2.7.7.7	ko:K02342,ko:K05847,ko:K07182	ko00230,ko00240,ko01100,ko02010,ko03030,ko03430,ko03440,map00230,map00240,map01100,map02010,map03030,map03430,map03440	M00209,M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko02000,ko03032,ko03400	3.A.1.12	-	-	CBS,DUF294,DUF294_C,cNMP_binding
LZS2_k127_3490110_6	330214.NIDE2743	6.494e-199	632.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,3J0B6@40117|Nitrospirae	40117|Nitrospirae	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
LZS2_k127_3490110_15	330214.NIDE2744	3.69e-137	442.0	COG0181@1|root,COG0181@2|Bacteria,3J0GC@40117|Nitrospirae	40117|Nitrospirae	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
LZS2_k127_3490110_5	330214.NIDE2745	8.224e-206	649.0	COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
LZS2_k127_3490110_19	330214.NIDE2746	1.748e-116	380.0	COG0755@1|root,COG0755@2|Bacteria,3J14H@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
LZS2_k127_3490110_44	330214.NIDE2747	4.755e-39	156.0	COG0313@1|root,COG0313@2|Bacteria,3J0PU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
LZS2_k127_3490110_49	330214.NIDE2748	1.916e-27	113.0	COG0425@1|root,COG0425@2|Bacteria,3J1DD@40117|Nitrospirae	40117|Nitrospirae	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
LZS2_k127_3490110_43	330214.NIDE2750	3.524e-45	164.0	COG2924@1|root,COG2924@2|Bacteria,3J1CU@40117|Nitrospirae	40117|Nitrospirae	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
LZS2_k127_3490110_31	330214.NIDE2751	1.541e-75	255.0	COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae	40117|Nitrospirae	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
LZS2_k127_3490110_40	330214.NIDE2752	3.564e-49	180.0	COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
LZS2_k127_3490110_33	330214.NIDE2753	5.528e-66	228.0	COG0102@1|root,COG0102@2|Bacteria,3J0NE@40117|Nitrospirae	40117|Nitrospirae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
LZS2_k127_3490110_37	330214.NIDE2754	1.386e-56	201.0	COG0103@1|root,COG0103@2|Bacteria,3J0N4@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
LZS2_k127_3490110_10	330214.NIDE2755	1.406e-157	503.0	COG0002@1|root,COG0002@2|Bacteria,3J0H9@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
LZS2_k127_3490110_12	330214.NIDE2756	1.815e-153	495.0	COG1364@1|root,COG1364@2|Bacteria,3J0B5@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
LZS2_k127_3490110_16	330214.NIDE2757	4.309e-122	396.0	COG0052@1|root,COG0052@2|Bacteria,3J0G9@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
LZS2_k127_3490110_23	330214.NIDE2758	5.065e-107	348.0	COG0264@1|root,COG0264@2|Bacteria,3J0I2@40117|Nitrospirae	40117|Nitrospirae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
LZS2_k127_3490110_17	330214.NIDE2759	3.732e-121	394.0	COG0528@1|root,COG0528@2|Bacteria,3J0BE@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
LZS2_k127_3490110_29	330214.NIDE2760	6.468e-84	283.0	COG0233@1|root,COG0233@2|Bacteria,3J0KJ@40117|Nitrospirae	40117|Nitrospirae	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
LZS2_k127_3490110_18	330214.NIDE2761	1.61e-119	394.0	COG0787@1|root,COG0787@2|Bacteria,3J0JH@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
LZS2_k127_3490110_9	330214.NIDE0556	1.148e-159	520.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	fadL	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
LZS2_k127_3490110_3	330214.NIDE0557	2.047e-246	792.0	COG0642@1|root,COG0745@1|root,COG2203@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA
LZS2_k127_3490110_42	330214.NIDE2763	1.066e-45	168.0	COG0011@1|root,COG0011@2|Bacteria,3J0QD@40117|Nitrospirae	40117|Nitrospirae	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
LZS2_k127_3490110_25	330214.NIDE2764	1.184e-93	314.0	COG1648@1|root,COG1648@2|Bacteria	2|Bacteria	H	precorrin-2 dehydrogenase activity	cysG	GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_3507,iECSE_1348.ECSE_3630,iEcE24377_1341.EcE24377A_3838,iJN746.PP_3999,iPC815.YPO0158	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
LZS2_k127_3490110_21	330214.NIDE2766	6.85e-111	359.0	COG1403@1|root,COG1403@2|Bacteria,3J0VM@40117|Nitrospirae	40117|Nitrospirae	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
LZS2_k127_3490110_48	330214.NIDE2767	9.565e-33	130.0	COG2146@1|root,COG2146@2|Bacteria,3J1E7@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
LZS2_k127_3490110_32	330214.NIDE2770	8.712e-70	238.0	COG2105@1|root,COG2105@2|Bacteria	2|Bacteria	F	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2,GGACT,Gamma_PGA_hydro
LZS2_k127_3490110_36	330214.NIDE2772	5.536e-58	202.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	fdx4	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
LZS2_k127_3490110_30	330214.NIDE2773	1.131e-80	271.0	COG0521@1|root,COG0521@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
LZS2_k127_3490110_39	330214.NIDE2775	2.713e-55	197.0	COG2905@1|root,COG2905@2|Bacteria,3J1AQ@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
LZS2_k127_3490110_11	330214.NIDE2776	9.332e-157	501.0	COG0604@1|root,COG0604@2|Bacteria,3J13T@40117|Nitrospirae	40117|Nitrospirae	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
LZS2_k127_3490110_14	330214.NIDE2777	1.316e-138	447.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	yddE	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
LZS2_k127_3490110_2	330214.NIDE2780	0.0	1082.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
LZS2_k127_3490110_0	330214.NIDE2781	0.0	1146.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,PqqD,Radical_SAM
LZS2_k127_3490110_51	1028801.RG1141_PA12930	2.366e-14	77.0	2FDIX@1|root,345KC@2|Bacteria,1PRTE@1224|Proteobacteria,2V41U@28211|Alphaproteobacteria,4BFPF@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3495233_13	330214.NIDE3923	1.773e-12	67.0	2ED3M@1|root,3370H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
LZS2_k127_3495233_2	330214.NIDE3925	3.739e-249	771.0	COG0446@1|root,COG0446@2|Bacteria,3J102@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
LZS2_k127_3495233_3	330214.NIDE3917	7.388e-131	426.0	COG0845@1|root,COG0845@2|Bacteria,3J13X@40117|Nitrospirae	40117|Nitrospirae	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
LZS2_k127_3495233_0	330214.NIDE3916	0.0	1667.0	COG0841@1|root,COG0841@2|Bacteria,3J0VZ@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
LZS2_k127_3495233_9	330214.NIDE3088	5.219e-42	160.0	COG2204@1|root,COG2204@2|Bacteria,3J107@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_3495233_1	935840.JAEQ01000021_gene4398	0.0	1157.0	COG0745@1|root,COG2199@1|root,COG4251@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
LZS2_k127_3495233_4	1210884.HG799463_gene9351	1.899e-122	400.0	COG1352@1|root,COG1352@2|Bacteria,2IXV1@203682|Planctomycetes	203682|Planctomycetes	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
LZS2_k127_3495233_8	886293.Sinac_0282	2.392e-62	236.0	COG0642@1|root,COG0784@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,2IXG1@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
LZS2_k127_3495233_12	1122929.KB908221_gene2846	3.336e-24	108.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2U0JP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	response regulator	nreC	-	-	ko:K02479,ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
LZS2_k127_3495233_6	234267.Acid_2792	3.2e-66	245.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,3Y4XJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
LZS2_k127_3495233_5	330214.NIDE3247	1.139e-67	237.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
LZS2_k127_3495233_10	330214.NIDE3967	9.886e-35	141.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
LZS2_k127_3534716_4	111780.Sta7437_2984	2.496e-05	49.0	COG1538@1|root,COG1538@2|Bacteria,1G0B8@1117|Cyanobacteria,3VIW8@52604|Pleurocapsales	1117|Cyanobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
LZS2_k127_3534716_2	330214.NIDE3201	8.779e-46	168.0	2C4PS@1|root,2ZHNK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3534716_3	468059.AUHA01000002_gene826	2.144e-41	154.0	COG0393@1|root,COG0393@2|Bacteria,4NQGB@976|Bacteroidetes	976|Bacteroidetes	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
LZS2_k127_3534716_0	1163409.UUA_01479	2.521e-90	309.0	COG4585@1|root,COG4585@2|Bacteria,1R9XM@1224|Proteobacteria,1S54U@1236|Gammaproteobacteria,1X997@135614|Xanthomonadales	135614|Xanthomonadales	T	STAS-like domain of unknown function (DUF4325)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4325
LZS2_k127_3538193_3	595537.Varpa_3801	4.889e-67	231.0	COG0662@1|root,COG0662@2|Bacteria,1N1YZ@1224|Proteobacteria,2VU48@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
LZS2_k127_3538193_5	105559.Nwat_1924	3.9e-17	81.0	COG1724@1|root,COG1724@2|Bacteria,1NHPS@1224|Proteobacteria,1SGDT@1236|Gammaproteobacteria,1WZRG@135613|Chromatiales	135613|Chromatiales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
LZS2_k127_3538193_4	765911.Thivi_1785	3.439e-18	84.0	COG1598@1|root,COG1598@2|Bacteria,1NF1P@1224|Proteobacteria,1SDMW@1236|Gammaproteobacteria,1WZBB@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3538193_0	330214.NIDE4368	8.302e-257	797.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
LZS2_k127_3538193_1	330214.NIDE4367	1.249e-171	551.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
LZS2_k127_3538193_2	330214.NIDE4364	5.491e-170	549.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE4364|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3538439_0	1163617.SCD_n02239	3.823e-137	443.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
LZS2_k127_3538439_2	330214.NIDE2953	1.32e-46	191.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	3.1.4.4	ko:K01115	ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231	-	R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000,ko04131	-	-	-	PLDc,PLDc_2
LZS2_k127_3538439_1	330214.NIDE2954	1.43e-71	263.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	AAA_13,AAA_23,Kelch_1,Kelch_4,Peptidase_C14,Tubulin_2,WD40
LZS2_k127_3570334_1	330214.NIDE3077	6.349e-137	440.0	COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae	40117|Nitrospirae	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
LZS2_k127_3570334_2	330214.NIDE3076	1.505e-29	120.0	29W29@1|root,30HKU@2|Bacteria,3J1EN@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF4321)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4321
LZS2_k127_3570334_0	330214.NIDE3074	4.965e-236	736.0	COG0541@1|root,COG0541@2|Bacteria,3J0DT@40117|Nitrospirae	40117|Nitrospirae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
LZS2_k127_3573565_15	1227261.HMPREF0043_02130	1.332e-10	66.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4D3SZ@85005|Actinomycetales	201174|Actinobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
LZS2_k127_3573565_2	330214.NIDE0749	4.266e-165	525.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	hcf136	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
LZS2_k127_3573565_9	330214.NIDE0748	7.03e-78	263.0	COG1666@1|root,COG1666@2|Bacteria,3J135@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF520)	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
LZS2_k127_3573565_0	330214.NIDE0747	0.0	1157.0	COG1966@1|root,COG1966@2|Bacteria,3J10E@40117|Nitrospirae	40117|Nitrospirae	T	5TM C-terminal transporter carbon starvation CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
LZS2_k127_3573565_18	330214.NIDE2510	1.934e-07	63.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	mazE	-	-	ko:K07172,ko:K18842	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
LZS2_k127_3573565_14	643473.KB235931_gene4855	7.452e-18	84.0	COG2442@1|root,COG2442@2|Bacteria,1GA44@1117|Cyanobacteria,1HPUY@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
LZS2_k127_3573565_17	1500257.JQNM01000006_gene1865	3.131e-09	64.0	2CNC8@1|root,32SGS@2|Bacteria,1NF7S@1224|Proteobacteria,2UVM6@28211|Alphaproteobacteria,4BJ5A@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3573565_13	376686.Fjoh_3596	1.579e-21	104.0	2CNC8@1|root,32SGS@2|Bacteria,4NPSP@976|Bacteroidetes,1I86A@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3573565_20	1396418.BATQ01000024_gene5204	0.0001259	47.0	COG0625@1|root,COG0625@2|Bacteria,46SQB@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
LZS2_k127_3573565_4	330214.NIDE0737	8.305e-124	405.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
LZS2_k127_3573565_3	330214.NIDE0736	1.357e-163	527.0	COG0558@1|root,COG1208@1|root,COG0558@2|Bacteria,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
LZS2_k127_3573565_5	330214.NIDE0735	7.379e-117	379.0	COG1213@1|root,COG1213@2|Bacteria,3J1BZ@40117|Nitrospirae	40117|Nitrospirae	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3573565_1	330214.NIDE0734	5.032e-179	567.0	COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae	2|Bacteria	E	Evidence 2b Function of strongly homologous gene	phnW	GO:0003674,GO:0003824	2.5.1.49,2.6.1.37,3.11.1.1	ko:K01740,ko:K03430,ko:K05306,ko:K09469	ko00270,ko00440,ko01100,ko01120,map00270,map00440,map01100,map01120	-	R00747,R01287,R04152,R04859	RC00008,RC00020,RC00062,RC00368,RC02821,RC02848	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
LZS2_k127_3573565_6	330214.NIDE0733	2.709e-109	359.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
LZS2_k127_3573565_8	330214.NIDE0732	2.787e-81	277.0	COG4032@1|root,COG4032@2|Bacteria	2|Bacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ppd	-	4.1.1.82	ko:K09459	ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130	-	R04053	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_N
LZS2_k127_3582192_0	330214.NIDE2282	6.083e-130	442.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE2282|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3582192_1	330214.NIDE2283	3.506e-16	83.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	gnfL	-	2.7.13.3	ko:K07708,ko:K07710,ko:K10942	ko02020,ko05111,map02020,map05111	M00497,M00500,M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
LZS2_k127_3582482_12	330214.NIDE2279	9.856e-61	215.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
LZS2_k127_3582482_6	330214.NIDE0907	9.331e-110	383.0	COG4249@1|root,COG4249@2|Bacteria,3J0QX@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Peptidase_C14
LZS2_k127_3582482_9	330214.NIDE0906	3.622e-84	288.0	COG0382@1|root,COG0382@2|Bacteria,3J0TY@40117|Nitrospirae	40117|Nitrospirae	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
LZS2_k127_3582482_3	330214.NIDE0905	2.225e-129	424.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K02305,ko:K07152	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko03029	3.D.4.10	-	-	Cytochrom_C,PA14,SCO1-SenC
LZS2_k127_3582482_5	330214.NIDE0904	4.437e-115	376.0	2ERPD@1|root,33J8R@2|Bacteria	2|Bacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
LZS2_k127_3582482_4	330214.NIDE0903	1.35e-119	387.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
LZS2_k127_3582482_7	330214.NIDE0902	8.056e-90	300.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	soxD	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
LZS2_k127_3582482_0	330214.NIDE0901	3e-323	997.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
LZS2_k127_3582482_1	330214.NIDE0899	1.185e-203	638.0	COG1290@1|root,COG1290@2|Bacteria,3J0Q6@40117|Nitrospirae	40117|Nitrospirae	C	Cytochrome b/b6/petB	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
LZS2_k127_3582482_2	330214.NIDE0898	5.27e-153	489.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K03886	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00151,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
LZS2_k127_3582482_10	330214.NIDE0897	6.384e-77	266.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K17052	-	-	-	-	ko00000,ko02000	5.A.3.8	-	-	Cytochrom_C,EB_dh
LZS2_k127_3582482_11	330214.NIDE0896	5.708e-61	213.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
LZS2_k127_3587303_6	1266925.JHVX01000001_gene2495	6.186e-22	96.0	arCOG08699@1|root,30TCX@2|Bacteria,1RDPE@1224|Proteobacteria,2WAZQ@28216|Betaproteobacteria,371U8@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	AmoC
LZS2_k127_3587303_1	330214.NIDE0190	4.035e-90	308.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	ycgE	-	-	ko:K21089,ko:K21972,ko:K22491	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
LZS2_k127_3587303_2	323848.Nmul_A2659	4.536e-85	286.0	COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2VPKX@28216|Betaproteobacteria,3728P@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM NapC NirT cytochrome c	napC	-	-	ko:K02569	-	-	-	-	ko00000	-	-	-	Cytochrom_NNT
LZS2_k127_3587303_5	330214.NIDE0895	4.663e-34	145.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
LZS2_k127_3587303_3	330214.NIDE4035	2.142e-66	241.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_3587303_8	1134912.AJTV01000013_gene558	1.783e-14	79.0	2DQ5D@1|root,334TW@2|Bacteria,1NI32@1224|Proteobacteria,2UMQG@28211|Alphaproteobacteria,370VT@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SMBP
LZS2_k127_3587303_4	330214.NIDE0189	8.135e-46	169.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
LZS2_k127_3587303_0	330214.NIDE0190	2.967e-144	464.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	ycgE	-	-	ko:K21089,ko:K21972,ko:K22491	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
LZS2_k127_3587303_10	330214.NIDE0192	2.468e-08	57.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
LZS2_k127_3601764_1	118168.MC7420_6697	3.406e-56	212.0	COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
LZS2_k127_3601764_0	314278.NB231_10523	1.019e-171	545.0	COG1980@1|root,COG1980@2|Bacteria,1MXM7@1224|Proteobacteria,1SKUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	-	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
LZS2_k127_3601764_2	1255043.TVNIR_1089	3.953e-21	94.0	COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,1SJ4Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
LZS2_k127_3601764_3	237609.PSAKL28_22670	3.02e-06	52.0	2BXI0@1|root,2Z9A2@2|Bacteria,1R9XN@1224|Proteobacteria,1S39A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2459)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2459
LZS2_k127_361093_2	2325.TKV_c21550	4.346e-07	54.0	COG1708@1|root,COG1708@2|Bacteria,1VCPX@1239|Firmicutes,24PE0@186801|Clostridia,42H2N@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS2_k127_361093_1	857087.Metme_0345	2.381e-34	138.0	COG1262@1|root,COG1262@2|Bacteria,1QY0H@1224|Proteobacteria	1224|Proteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
LZS2_k127_361093_0	330214.NIDE0158	3.858e-205	642.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
LZS2_k127_3631287_4	1267534.KB906757_gene889	2.758e-12	75.0	COG0489@1|root,COG0489@2|Bacteria,3Y59M@57723|Acidobacteria,2JJS6@204432|Acidobacteriia	204432|Acidobacteriia	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
LZS2_k127_3631287_2	926566.Terro_2823	3.663e-63	237.0	COG3206@1|root,COG3206@2|Bacteria,3Y3JI@57723|Acidobacteria,2JI13@204432|Acidobacteriia	204432|Acidobacteriia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
LZS2_k127_3631287_0	1038862.KB893829_gene4991	7.889e-245	771.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,3JS0Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
LZS2_k127_3631287_3	247490.KSU1_A0047	3.368e-35	150.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4861,Glyco_hydro_76
LZS2_k127_3631287_1	443144.GM21_3186	1.182e-102	342.0	COG1215@1|root,COG1215@2|Bacteria,1R4ZM@1224|Proteobacteria,42T5P@68525|delta/epsilon subdivisions,2WPSG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS2_k127_3644614_23	697282.Mettu_3255	2.863e-21	96.0	2E7TI@1|root,333ZE@2|Bacteria,1NA5N@1224|Proteobacteria,1SE9F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TRL-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	TRL
LZS2_k127_3644614_24	330214.NIDE1885	2.495e-19	96.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	MtrB_PioB,OMP_b-brl
LZS2_k127_3644614_25	215803.DB30_0919	3.206e-11	72.0	2ARAZ@1|root,31GKZ@2|Bacteria,1NPW3@1224|Proteobacteria,43320@68525|delta/epsilon subdivisions,2WY42@28221|Deltaproteobacteria,2YWBI@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3332
LZS2_k127_3644614_6	330214.NIDE4192	2.905e-144	466.0	COG4783@1|root,COG4783@2|Bacteria,3J19Q@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
LZS2_k127_3644614_7	330214.NIDE4194	4.962e-124	400.0	COG2013@1|root,COG2013@2|Bacteria	2|Bacteria	S	Mitochondrial biogenesis AIM24	WQ51_05710	-	-	-	-	-	-	-	-	-	-	-	AIM24
LZS2_k127_3644614_12	1122603.ATVI01000005_gene2979	9.718e-93	325.0	COG2159@1|root,COG2159@2|Bacteria,1QDV1@1224|Proteobacteria,1RYCT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
LZS2_k127_3644614_1	330214.NIDE4203	2.496e-199	674.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE4203|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3644614_16	1162668.LFE_1670	1.405e-69	257.0	COG1450@1|root,COG1450@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	gspD	-	-	ko:K02453,ko:K03219	ko03070,ko05111,map03070,map05111	M00331,M00332,M00542	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15,3.A.6.1,3.A.6.3	-	-	Secretin,Secretin_N
LZS2_k127_3644614_8	1283300.ATXB01000001_gene1625	5.321e-120	395.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1XDZ4@135618|Methylococcales	135618|Methylococcales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
LZS2_k127_3644614_13	330214.NIDE0783	5.226e-86	289.0	COG0193@1|root,COG0193@2|Bacteria,3J0QR@40117|Nitrospirae	40117|Nitrospirae	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
LZS2_k127_3644614_11	330214.NIDE0782	7.491e-93	312.0	COG1825@1|root,COG1825@2|Bacteria,3J0NK@40117|Nitrospirae	40117|Nitrospirae	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
LZS2_k127_3644614_4	330214.NIDE0781	1.119e-166	529.0	COG0462@1|root,COG0462@2|Bacteria,3J0D0@40117|Nitrospirae	40117|Nitrospirae	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
LZS2_k127_3644614_10	330214.NIDE0780	4.887e-94	317.0	COG1947@1|root,COG1947@2|Bacteria,3J0N1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
LZS2_k127_3644614_5	1232410.KI421416_gene2592	4.579e-156	505.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_3644614_0	330214.NIDE0778	7.361e-249	780.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
LZS2_k127_3644614_3	330214.NIDE0777	1.044e-195	617.0	COG1459@1|root,COG1459@2|Bacteria,3J0HZ@40117|Nitrospirae	40117|Nitrospirae	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
LZS2_k127_3644614_19	330214.NIDE0775	1.564e-56	202.0	COG0558@1|root,COG0558@2|Bacteria,3J183@40117|Nitrospirae	40117|Nitrospirae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
LZS2_k127_3644614_9	330214.NIDE0773	9.149e-118	391.0	COG1680@1|root,COG1680@2|Bacteria,3J131@40117|Nitrospirae	40117|Nitrospirae	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
LZS2_k127_3644614_18	330214.NIDE0772	1.521e-58	207.0	COG3599@1|root,COG3599@2|Bacteria,3J19M@40117|Nitrospirae	40117|Nitrospirae	D	DivIVA protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
LZS2_k127_3644614_21	330214.NIDE0771	9.043e-34	136.0	COG0762@1|root,COG0762@2|Bacteria,3J0U5@40117|Nitrospirae	40117|Nitrospirae	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
LZS2_k127_3644614_14	330214.NIDE0770	2.549e-85	291.0	COG0345@1|root,COG0345@2|Bacteria,3J0N8@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
LZS2_k127_3644614_17	330214.NIDE0769	8.506e-68	237.0	COG0325@1|root,COG0325@2|Bacteria,3J0RJ@40117|Nitrospirae	40117|Nitrospirae	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
LZS2_k127_3644614_15	330214.NIDE0768	5.064e-79	271.0	COG1496@1|root,COG1496@2|Bacteria,3J0TC@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
LZS2_k127_3644614_2	330214.NIDE0767	3.46e-197	620.0	COG0206@1|root,COG0206@2|Bacteria,3J0D4@40117|Nitrospirae	40117|Nitrospirae	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
LZS2_k127_3648365_0	1242864.D187_008103	1.365e-09	68.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg
LZS2_k127_3674630_15	330214.NIDE0159	3.886e-56	199.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	yurZ	-	2.3.1.12,4.1.1.44	ko:K00627,ko:K01607	ko00010,ko00020,ko00362,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00020,map00362,map00620,map01100,map01110,map01120,map01130,map01200,map01220	M00307	R00209,R02569,R03470	RC00004,RC00938,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CMD
LZS2_k127_3674630_6	330214.NIDE0161	4.002e-99	330.0	COG0483@1|root,COG0483@2|Bacteria,3J0I4@40117|Nitrospirae	40117|Nitrospirae	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
LZS2_k127_3674630_2	330214.NIDE0164	1.334e-127	415.0	COG0774@1|root,COG0774@2|Bacteria,3J0JG@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
LZS2_k127_3674630_24	330214.NIDE3139	1.858e-06	51.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
LZS2_k127_3674630_4	443144.GM21_0057	1.267e-114	392.0	COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,43BMJ@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,CHASE8,GAF,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg,SBP_bac_3,dCache_1
LZS2_k127_3674630_12	1122604.JONR01000070_gene4528	6.709e-73	262.0	COG2199@1|root,COG3279@1|root,COG3279@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RY2M@1236|Gammaproteobacteria,1X6IZ@135614|Xanthomonadales	135614|Xanthomonadales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
LZS2_k127_3674630_18	1210884.HG799473_gene14941	6.494e-51	188.0	2CAZH@1|root,2Z7RU@2|Bacteria,2IZW6@203682|Planctomycetes	203682|Planctomycetes	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	-
LZS2_k127_3674630_0	1382359.JIAL01000001_gene2876	7.316e-300	931.0	COG1053@1|root,COG1053@2|Bacteria,3Y2MQ@57723|Acidobacteria,2JIC4@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
LZS2_k127_3674630_5	700598.Niako_0894	2.631e-101	336.0	COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,1IQMQ@117747|Sphingobacteriia	976|Bacteroidetes	C	Succinate dehydrogenase fumarate reductase Fe-S protein subunit	frdB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
LZS2_k127_3674630_9	330214.NIDE4332	2.578e-95	316.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
LZS2_k127_3674630_10	330214.NIDE4331	4.725e-90	305.0	COG1512@1|root,COG1512@2|Bacteria	2|Bacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
LZS2_k127_3674630_23	1177154.Y5S_00565	2.374e-21	104.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,1S2RR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
LZS2_k127_3674630_20	330214.NIDE0366	3.241e-37	146.0	COG1664@1|root,COG1664@2|Bacteria,3J1F5@40117|Nitrospirae	40117|Nitrospirae	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
LZS2_k127_3674630_1	330214.NIDE4329	2.464e-250	782.0	COG0728@1|root,COG0728@2|Bacteria,3J0CQ@40117|Nitrospirae	40117|Nitrospirae	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
LZS2_k127_3674630_17	330214.NIDE4328	3.018e-51	186.0	COG0350@1|root,COG0350@2|Bacteria,3J1A8@40117|Nitrospirae	40117|Nitrospirae	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
LZS2_k127_3674630_16	330214.NIDE4327	2.963e-55	196.0	COG1490@1|root,COG1490@2|Bacteria,3J149@40117|Nitrospirae	40117|Nitrospirae	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
LZS2_k127_3674630_8	330214.NIDE4326	4.593e-96	317.0	2CK1C@1|root,32SJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3674630_7	330214.NIDE4324	9.258e-99	331.0	COG1446@1|root,COG1446@2|Bacteria,3J19S@40117|Nitrospirae	40117|Nitrospirae	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
LZS2_k127_3674630_14	330214.NIDE4323	3.559e-57	203.0	COG3565@1|root,COG3565@2|Bacteria	2|Bacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
LZS2_k127_3674630_25	330214.NIDE4322	0.0003718	44.0	COG0744@1|root,COG0744@2|Bacteria,3J127@40117|Nitrospirae	40117|Nitrospirae	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
LZS2_k127_3681949_3	330214.NIDE1675	9.11e-45	168.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	2.1.1.170,2.1.1.185	ko:K03218,ko:K03437,ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03016,ko03036	-	-	-	SpoU_methylase,SpoU_sub_bind
LZS2_k127_3681949_1	330214.NIDE3249	8.29e-139	452.0	COG1538@1|root,COG1538@2|Bacteria,3J1F2@40117|Nitrospirae	40117|Nitrospirae	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
LZS2_k127_3681949_2	330214.NIDE3250	1.004e-133	437.0	COG0845@1|root,COG0845@2|Bacteria,3J15V@40117|Nitrospirae	2|Bacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	cusB	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
LZS2_k127_3681949_0	330214.NIDE3251	0.0	1444.0	COG3696@1|root,COG3696@2|Bacteria	2|Bacteria	P	silver ion transport	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
LZS2_k127_3681949_4	330214.NIDE4373	6.335e-27	117.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_3681949_5	1121382.JQKG01000066_gene2641	5.609e-16	80.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
LZS2_k127_3688192_1	686578.AFFX01000005_gene4250	1.064e-110	361.0	COG1451@1|root,COG1451@2|Bacteria,1R8SX@1224|Proteobacteria,1RNX7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
LZS2_k127_3688192_2	643648.Slip_1959	9.441e-59	211.0	COG2110@1|root,COG3465@1|root,COG2110@2|Bacteria,COG3465@2|Bacteria,1UY8V@1239|Firmicutes,24C22@186801|Clostridia	186801|Clostridia	S	Macro domain	-	-	-	-	-	-	-	-	-	-	-	-	Macro
LZS2_k127_3688192_0	330214.NIDE4110	5.346e-295	912.0	COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
LZS2_k127_3688192_4	330214.NIDE4109	1.169e-46	168.0	COG0776@1|root,COG0776@2|Bacteria,3J1CY@40117|Nitrospirae	40117|Nitrospirae	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
LZS2_k127_3688192_3	330214.NIDE4108	7.397e-48	174.0	COG0789@1|root,COG0789@2|Bacteria,3J0VF@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
LZS2_k127_3697657_7	330214.NIDE1690	2.469e-56	199.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CZB,MCPsignal,dCache_1
LZS2_k127_3697657_9	441620.Mpop_5123	4.701e-43	163.0	COG4803@1|root,COG4803@2|Bacteria,1RC5W@1224|Proteobacteria,2U8DH@28211|Alphaproteobacteria,1JR3N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
LZS2_k127_3697657_6	666681.M301_0441	9.476e-57	204.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria	28216|Betaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
LZS2_k127_3697657_2	1165096.ARWF01000001_gene1604	4.515e-81	280.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
LZS2_k127_3697657_1	666681.M301_0443	3.264e-109	358.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
LZS2_k127_3697657_11	666681.M301_0444	3.108e-08	58.0	COG3114@1|root,COG3114@2|Bacteria	2|Bacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmD	GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735	CcmD
LZS2_k127_3697657_5	666681.M301_0445	7.777e-59	207.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
LZS2_k127_3697657_0	1165096.ARWF01000001_gene1608	3.377e-307	953.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
LZS2_k127_3697657_3	228410.NE0769	1.414e-70	242.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,372UU@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	oxidoreductase DsbE	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
LZS2_k127_3697657_8	666681.M301_0448	4.115e-46	170.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria	28216|Betaproteobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
LZS2_k127_3697657_4	1485544.JQKP01000007_gene1986	1.933e-70	255.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,44V8W@713636|Nitrosomonadales	28216|Betaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcmI	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
LZS2_k127_3697657_10	1266925.JHVX01000004_gene1315	6.624e-30	122.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,2W61W@28216|Betaproteobacteria,371TC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	anaerobic respiration	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Multi-haem_cyto
LZS2_k127_371973_0	330214.NIDE0356	7.127e-221	698.0	COG0166@1|root,COG0166@2|Bacteria	2|Bacteria	G	Belongs to the GPI family	tal	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI,TAL_FSA
LZS2_k127_371973_4	330214.NIDE0355	2.387e-67	237.0	COG0363@1|root,COG0363@2|Bacteria,3J18W@40117|Nitrospirae	40117|Nitrospirae	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
LZS2_k127_371973_1	330214.NIDE0354	1.944e-168	535.0	COG0837@1|root,COG0837@2|Bacteria,3J13D@40117|Nitrospirae	40117|Nitrospirae	F	Glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
LZS2_k127_371973_3	330214.NIDE0353	8.739e-99	329.0	COG0120@1|root,COG0120@2|Bacteria	2|Bacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.7.1.12,2.7.1.15,5.3.1.6	ko:K00851,ko:K00852,ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01051,R01056,R01737,R02750	RC00002,RC00017,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
LZS2_k127_371973_2	330214.NIDE0352	1.714e-151	491.0	COG0308@1|root,COG0308@2|Bacteria,3J0Y4@40117|Nitrospirae	40117|Nitrospirae	E	Peptidase family M1 domain	-	-	-	ko:K08776	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
LZS2_k127_3747484_0	330214.NIDE1411	8.571e-270	835.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
LZS2_k127_3747484_4	330214.NIDE1412	1.194e-35	139.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	CCP_MauG,Copper-bind,Cu-oxidase_3,Cupredoxin_1
LZS2_k127_3747484_3	330214.NIDE1416	3.633e-69	247.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_3,Pentapeptide_4
LZS2_k127_3747484_1	330214.NIDE1417	1.888e-104	345.0	COG1354@1|root,COG1354@2|Bacteria,3J13J@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
LZS2_k127_3747484_2	330214.NIDE1418	5.733e-79	272.0	COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae	40117|Nitrospirae	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
LZS2_k127_3754875_0	330214.NIDE0344	9.81e-157	500.0	COG0714@1|root,COG0714@2|Bacteria,3J0WQ@40117|Nitrospirae	40117|Nitrospirae	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
LZS2_k127_3754875_2	330214.NIDE0343	5.535e-83	282.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
LZS2_k127_3789213_0	330214.NIDE3590	2.537e-27	116.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,zf-HC2
LZS2_k127_3790132_11	330214.NIDE1294	8.491e-20	89.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
LZS2_k127_3790132_2	330214.NIDE1308	0.0	1270.0	COG0480@1|root,COG0480@2|Bacteria,3J0EK@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
LZS2_k127_3790132_8	289376.THEYE_A1450	2.552e-63	220.0	COG0049@1|root,COG0049@2|Bacteria,3J0HK@40117|Nitrospirae	40117|Nitrospirae	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
LZS2_k127_3790132_7	330214.NIDE1306	1.591e-69	237.0	COG0048@1|root,COG0048@2|Bacteria,3J0IU@40117|Nitrospirae	40117|Nitrospirae	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
LZS2_k127_3790132_0	330214.NIDE1304	0.0	2534.0	COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae	40117|Nitrospirae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
LZS2_k127_3790132_1	316067.Geob_3632	0.0	1677.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43T41@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
LZS2_k127_3790132_3	330214.NIDE1302	5.031e-147	471.0	COG0222@1|root,COG0244@1|root,COG0222@2|Bacteria,COG0244@2|Bacteria,3J0NQ@40117|Nitrospirae	40117|Nitrospirae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
LZS2_k127_3790132_4	330214.NIDE1301	1.175e-123	400.0	COG0081@1|root,COG0081@2|Bacteria,3J0GB@40117|Nitrospirae	40117|Nitrospirae	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
LZS2_k127_3790132_6	330214.NIDE1300	1.221e-73	250.0	COG0080@1|root,COG0080@2|Bacteria,3J0K2@40117|Nitrospirae	40117|Nitrospirae	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
LZS2_k127_3790132_5	330214.NIDE1299	5.623e-97	318.0	COG0250@1|root,COG0250@2|Bacteria,3J0JA@40117|Nitrospirae	40117|Nitrospirae	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
LZS2_k127_3790132_12	330214.NIDE1298	1.002e-17	84.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
LZS2_k127_3790132_10	330214.NIDE1295	4.442e-22	96.0	COG0267@1|root,COG0267@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
LZS2_k127_3790132_9	330214.NIDE1294	9.053e-32	124.0	COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae	40117|Nitrospirae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	-	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
LZS2_k127_3802725_0	330214.NIDE2408	4.151e-133	432.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K07011,ko:K16706	-	-	-	-	ko00000	-	-	-	GNVR,Wzz
LZS2_k127_3802725_1	330214.NIDE2407	2.313e-130	425.0	COG5338@1|root,COG5338@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2,CarbopepD_reg_2,DUF560,Plug
LZS2_k127_3813518_2	330214.NIDE1172	1.003e-102	335.0	COG1805@1|root,COG4402@1|root,COG1805@2|Bacteria,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2330,NQR2_RnfD_RnfE
LZS2_k127_3813518_4	879212.DespoDRAFT_00192	3.364e-07	61.0	2BYE3@1|root,32UE0@2|Bacteria,1N2IT@1224|Proteobacteria,42URS@68525|delta/epsilon subdivisions,2WQ8M@28221|Deltaproteobacteria,2MKGT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_3813518_1	316055.RPE_2080	5.169e-197	623.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,3JSY1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
LZS2_k127_3813518_0	330214.NIDE1167	0.0	1761.0	COG1201@1|root,COG1201@2|Bacteria	2|Bacteria	L	RNA secondary structure unwinding	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
LZS2_k127_3817800_33	330214.NIDE0028	9.163e-39	148.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS2_k127_3817800_24	330214.NIDE0983	1.615e-92	308.0	COG0118@1|root,COG0118@2|Bacteria,3J0K7@40117|Nitrospirae	40117|Nitrospirae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
LZS2_k127_3817800_19	330214.NIDE0985	4.37e-112	366.0	COG0106@1|root,COG0106@2|Bacteria,3J0KA@40117|Nitrospirae	40117|Nitrospirae	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
LZS2_k127_3817800_18	443143.GM18_4149	7.667e-115	375.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
LZS2_k127_3817800_23	330214.NIDE0987	8.466e-94	314.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,3J0T7@40117|Nitrospirae	40117|Nitrospirae	E	Phosphoribosyl-AMP cyclohydrolase	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
LZS2_k127_3817800_32	330214.NIDE0988	1.572e-44	167.0	COG0537@1|root,COG0537@2|Bacteria,3J0TA@40117|Nitrospirae	40117|Nitrospirae	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
LZS2_k127_3817800_5	330214.NIDE0989	2.418e-221	702.0	COG0358@1|root,COG0358@2|Bacteria,3J0IN@40117|Nitrospirae	40117|Nitrospirae	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
LZS2_k127_3817800_10	316067.Geob_0699	1.049e-181	587.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,43U19@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
LZS2_k127_3817800_27	330214.NIDE0991	1.899e-82	283.0	COG1579@1|root,COG1579@2|Bacteria,3J0UV@40117|Nitrospirae	40117|Nitrospirae	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
LZS2_k127_3817800_22	330214.NIDE0992	7.894e-94	312.0	COG1039@1|root,COG1039@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	rnhC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF3378,RNase_HII
LZS2_k127_3817800_16	330214.NIDE0993	2.518e-119	391.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
LZS2_k127_3817800_1	330214.NIDE0997	0.0	1111.0	COG0028@1|root,COG0028@2|Bacteria,3J0D6@40117|Nitrospirae	40117|Nitrospirae	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
LZS2_k127_3817800_25	330214.NIDE0998	9.451e-90	298.0	COG0440@1|root,COG0440@2|Bacteria,3J0K8@40117|Nitrospirae	40117|Nitrospirae	E	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
LZS2_k127_3817800_6	330214.NIDE0999	9.929e-204	636.0	COG0059@1|root,COG0059@2|Bacteria,3J0DW@40117|Nitrospirae	40117|Nitrospirae	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
LZS2_k127_3817800_21	330214.NIDE1000	1.856e-100	331.0	COG0688@1|root,COG0688@2|Bacteria,3J0KD@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
LZS2_k127_3817800_20	330214.NIDE1001	3.957e-103	343.0	COG1183@1|root,COG1183@2|Bacteria,3J0KW@40117|Nitrospirae	40117|Nitrospirae	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
LZS2_k127_3817800_3	330214.NIDE1002	2.55e-275	855.0	COG0119@1|root,COG0119@2|Bacteria,3J0F7@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
LZS2_k127_3817800_34	330214.NIDE1004	3.522e-37	144.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
LZS2_k127_3817800_8	330214.NIDE1005	3.941e-192	604.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
LZS2_k127_3817800_14	330214.NIDE1006	3.845e-128	421.0	COG3391@1|root,COG3391@2|Bacteria,3J19W@40117|Nitrospirae	2|Bacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,NHL,TIG
LZS2_k127_3817800_11	330214.NIDE1007	2.632e-177	559.0	COG0136@1|root,COG0136@2|Bacteria,3J0BR@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
LZS2_k127_3817800_36	330214.NIDE1008	9.952e-24	102.0	2DNS1@1|root,32YVX@2|Bacteria,3J1CZ@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
LZS2_k127_3817800_13	330214.NIDE1009	6.01e-135	442.0	COG2385@1|root,COG2385@2|Bacteria,3J15K@40117|Nitrospirae	40117|Nitrospirae	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
LZS2_k127_3817800_17	330214.NIDE1010	9.186e-116	386.0	COG0809@1|root,COG0809@2|Bacteria,3J0HB@40117|Nitrospirae	40117|Nitrospirae	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
LZS2_k127_3817800_28	330214.NIDE1011	2.865e-81	276.0	COG0760@1|root,COG0760@2|Bacteria,3J1BR@40117|Nitrospirae	40117|Nitrospirae	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	SurA_N_3
LZS2_k127_3817800_31	330214.NIDE1012	6.292e-54	194.0	COG1714@1|root,COG1714@2|Bacteria,3J0U3@40117|Nitrospirae	40117|Nitrospirae	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
LZS2_k127_3817800_7	330214.NIDE1013	1.221e-203	637.0	COG1077@1|root,COG1077@2|Bacteria,3J0BS@40117|Nitrospirae	40117|Nitrospirae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
LZS2_k127_3817800_26	330214.NIDE1014	3.213e-89	305.0	COG1792@1|root,COG1792@2|Bacteria,3J0S3@40117|Nitrospirae	40117|Nitrospirae	M	shape-determining protein MreC	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
LZS2_k127_3817800_2	330214.NIDE1016	7.282e-301	932.0	COG0768@1|root,COG0768@2|Bacteria,3J0FY@40117|Nitrospirae	40117|Nitrospirae	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
LZS2_k127_3817800_9	330214.NIDE1017	1.145e-184	582.0	COG0772@1|root,COG0772@2|Bacteria,3J0IA@40117|Nitrospirae	40117|Nitrospirae	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
LZS2_k127_3817800_12	338966.Ppro_0350	1.4e-171	553.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,43TM0@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
LZS2_k127_3817800_15	330214.NIDE1019	5.136e-124	409.0	COG0758@1|root,COG0758@2|Bacteria,3J0Q8@40117|Nitrospirae	40117|Nitrospirae	L	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
LZS2_k127_3817800_0	330214.NIDE1020	0.0	1359.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,3J0DN@40117|Nitrospirae	40117|Nitrospirae	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
LZS2_k127_3817800_37	1121403.AUCV01000014_gene4623	3e-13	78.0	COG3637@1|root,COG3637@2|Bacteria,1NHDI@1224|Proteobacteria,42X8Q@68525|delta/epsilon subdivisions,2WTDT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
LZS2_k127_3817800_4	118163.Ple7327_0161	7.087e-257	803.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,3VIAJ@52604|Pleurocapsales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.39,1.2.1.79,1.2.1.8	ko:K00130,ko:K00135,ko:K00146,ko:K22187	ko00040,ko00250,ko00260,ko00310,ko00350,ko00360,ko00643,ko00650,ko00760,ko01100,ko01120,map00040,map00250,map00260,map00310,map00350,map00360,map00643,map00650,map00760,map01100,map01120	M00027,M00555	R00713,R00714,R02401,R02536,R02565,R02566,R11768	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
LZS2_k127_3817800_29	1121121.KB894299_gene4323	2.542e-68	238.0	COG0693@1|root,COG0693@2|Bacteria,1V4AR@1239|Firmicutes,4HH2G@91061|Bacilli,26U95@186822|Paenibacillaceae	91061|Bacilli	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
LZS2_k127_3832127_0	589865.DaAHT2_1068	2.057e-159	509.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
LZS2_k127_3875880_1	1280948.HY36_17900	1.387e-72	256.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
LZS2_k127_3875880_0	926569.ANT_31690	2.034e-81	273.0	COG0286@1|root,COG0286@2|Bacteria,2G899@200795|Chloroflexi	200795|Chloroflexi	L	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I
LZS2_k127_3898120_0	330214.NIDE2405	1.609e-240	764.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,3J17M@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K07114,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,VWA_2
LZS2_k127_3898120_1	330214.NIDE2406	9.934e-73	250.0	COG1596@1|root,COG1596@2|Bacteria,3J17R@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
LZS2_k127_3898120_2	330214.NIDE2407	4.904e-11	66.0	COG5338@1|root,COG5338@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2,CarbopepD_reg_2,DUF560,Plug
LZS2_k127_3918242_2	330214.NIDE4381	5.777e-29	118.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	MA20_24420	-	-	ko:K06889,ko:K07000	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4,UPF0227
LZS2_k127_3918242_1	1162668.LFE_2264	8.743e-159	520.0	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	2|Bacteria	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K02022,ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS2_k127_3918242_0	1266925.JHVX01000004_gene1263	1.479e-169	540.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria,2VISH@28216|Betaproteobacteria	28216|Betaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
LZS2_k127_3999200_1	330214.NIDE2970	6.185e-68	234.0	COG0084@1|root,COG0084@2|Bacteria,3J0KM@40117|Nitrospirae	40117|Nitrospirae	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
LZS2_k127_3999200_3	330214.NIDE3526	1.012e-26	117.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_3999200_2	330214.NIDE3525	1.121e-59	219.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4880,DUF4974,FecR
LZS2_k127_3999200_0	330214.NIDE2183	4.444e-175	560.0	COG4774@1|root,COG4774@2|Bacteria	2|Bacteria	P	siderophore transport	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,STN,TonB_dep_Rec
LZS2_k127_4048795_7	1150621.SMUL_1243	3.019e-21	96.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
LZS2_k127_4048795_11	1565314.OA34_03655	1.278e-10	65.0	2B33V@1|root,31VRH@2|Bacteria,1QTMF@1224|Proteobacteria,42VGS@68525|delta/epsilon subdivisions,2YQ90@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
LZS2_k127_4048795_0	330214.NIDE1643	0.0	1121.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
LZS2_k127_4048795_2	330214.NIDE1644	5.173e-163	524.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,Peptidase_C14
LZS2_k127_4048795_5	330214.NIDE1646	9.175e-82	276.0	2EUFJ@1|root,33MXU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
LZS2_k127_4048795_4	330214.NIDE1647	9.215e-93	310.0	COG3417@1|root,COG3417@2|Bacteria,3J16N@40117|Nitrospirae	40117|Nitrospirae	M	Peptidoglycan-synthase activator LpoB	-	-	-	ko:K07337	-	-	-	-	ko00000	-	-	-	LpoB
LZS2_k127_4048795_1	330214.NIDE1648	4.868e-173	556.0	COG3014@1|root,COG3014@2|Bacteria,3J14B@40117|Nitrospirae	40117|Nitrospirae	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
LZS2_k127_4048795_3	330214.NIDE1649	1.216e-114	383.0	2AAUK@1|root,3107C@2|Bacteria,3J1E0@40117|Nitrospirae	40117|Nitrospirae	S	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
LZS2_k127_4048795_6	330214.NIDE1651	2.027e-71	244.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
LZS2_k127_4053072_11	330214.NIDE1922	1.717e-64	225.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_4053072_13	1122164.JHWF01000014_gene1830	1.254e-52	198.0	COG2239@1|root,COG2239@2|Bacteria,1PPTF@1224|Proteobacteria,1T7VZ@1236|Gammaproteobacteria,1JFXH@118969|Legionellales	118969|Legionellales	P	Divalent cation transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE
LZS2_k127_4053072_14	330214.NIDE1925	1.193e-48	180.0	COG0589@1|root,COG0589@2|Bacteria,3J1E9@40117|Nitrospirae	40117|Nitrospirae	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_4053072_15	330214.NIDE1926	1.055e-42	160.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	amcY	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cupredoxin_1
LZS2_k127_4053072_8	330214.NIDE1927	6.914e-77	268.0	COG0589@1|root,COG0589@2|Bacteria,3J1A7@40117|Nitrospirae	40117|Nitrospirae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_4053072_2	330214.NIDE3182	5.3e-191	604.0	COG0205@1|root,COG0205@2|Bacteria,3J0Y1@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
LZS2_k127_4053072_5	330214.NIDE3757	1.468e-95	320.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_4053072_18	102129.Lepto7375DRAFT_6681	3.88e-39	154.0	COG1846@1|root,COG1846@2|Bacteria,1G6G4@1117|Cyanobacteria,1HGTR@1150|Oscillatoriales	1117|Cyanobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
LZS2_k127_4053072_7	330214.NIDE4041	7.918e-84	280.0	COG1592@1|root,COG1592@2|Bacteria,3J0RY@40117|Nitrospirae	40117|Nitrospirae	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
LZS2_k127_4053072_1	330214.NIDE4040	8.212e-194	612.0	COG0247@1|root,COG1146@1|root,COG0247@2|Bacteria,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3,1.2.7.3	ko:K00113,ko:K00176,ko:K05524,ko:K13795,ko:K13796	ko00020,ko00564,ko00720,ko01100,ko01110,ko01120,ko01200,map00020,map00564,map00720,map01100,map01110,map01120,map01200	M00009,M00011,M00173,M00620	R00848,R01197	RC00004,RC00029,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	CCG,DUF3470,DUF3501,Fer4,Fer4_8
LZS2_k127_4053072_9	330214.NIDE4039	1.507e-67	235.0	COG0247@1|root,COG0247@2|Bacteria,3J187@40117|Nitrospirae	40117|Nitrospirae	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
LZS2_k127_4053072_4	330214.NIDE4038	1.139e-96	322.0	COG0720@1|root,COG0720@2|Bacteria,3J0TW@40117|Nitrospirae	40117|Nitrospirae	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
LZS2_k127_4053072_19	1266925.JHVX01000012_gene1719	2.621e-34	137.0	2CBQ4@1|root,32RTT@2|Bacteria,1N3I2@1224|Proteobacteria,2VV48@28216|Betaproteobacteria,374AA@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4053072_17	1266925.JHVX01000022_gene1762	3.536e-39	151.0	2CBQ4@1|root,32RTT@2|Bacteria,1N3I2@1224|Proteobacteria,2VV48@28216|Betaproteobacteria,3739D@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4053072_12	330214.NIDE4034	6.221e-57	200.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	bta	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin,TraF
LZS2_k127_4053072_6	330214.NIDE4033	8.931e-86	287.0	COG1225@1|root,COG1225@2|Bacteria,3J12D@40117|Nitrospirae	40117|Nitrospirae	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
LZS2_k127_4053072_0	330214.NIDE4031	1.465e-226	707.0	COG1217@1|root,COG1217@2|Bacteria,3J10A@40117|Nitrospirae	40117|Nitrospirae	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU
LZS2_k127_4067336_0	330214.NIDE2263	0.0	1210.0	COG0542@1|root,COG0542@2|Bacteria,3J0AV@40117|Nitrospirae	40117|Nitrospirae	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
LZS2_k127_4067336_1	330214.NIDE2260	2.638e-230	722.0	COG0606@1|root,COG0606@2|Bacteria,3J0ZK@40117|Nitrospirae	40117|Nitrospirae	O	Magnesium chelatase, subunit ChlI C-terminal	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
LZS2_k127_4067336_3	330214.NIDE2258	5.214e-32	126.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
LZS2_k127_4082986_6	1123256.KB907925_gene1399	1.032e-80	282.0	COG1226@1|root,COG1226@2|Bacteria,1MXQP@1224|Proteobacteria,1SWIH@1236|Gammaproteobacteria,1XAQW@135614|Xanthomonadales	135614|Xanthomonadales	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_N
LZS2_k127_4082986_0	330214.NIDE3945	9.837e-208	651.0	COG0025@1|root,COG0025@2|Bacteria	2|Bacteria	P	sodium:proton antiporter activity	nhaP	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
LZS2_k127_4082986_9	331678.Cphamn1_0895	6.498e-56	211.0	COG0025@1|root,COG0025@2|Bacteria	2|Bacteria	P	sodium:proton antiporter activity	cdu2	-	-	ko:K05564,ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6,2.A.63.1	-	-	Na_H_Exchanger,Usp
LZS2_k127_4082986_3	330214.NIDE3947	1.375e-148	494.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	mscM	-	-	-	-	-	-	-	-	-	-	-	MS_channel
LZS2_k127_4082986_1	228410.NE0448	3.298e-191	606.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,372HN@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Ammonium transporter	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
LZS2_k127_4082986_2	247490.KSU1_C0383	3.329e-186	590.0	COG4487@1|root,COG4487@2|Bacteria,2J16Y@203682|Planctomycetes	203682|Planctomycetes	I	mechanosensitive ion channel activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
LZS2_k127_4082986_4	330214.NIDE1195	1.053e-126	410.0	COG0351@1|root,COG0351@2|Bacteria,3J0RM@40117|Nitrospirae	40117|Nitrospirae	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
LZS2_k127_4082986_5	330214.NIDE1193	1.811e-93	313.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH,Hydrolase_4
LZS2_k127_4097441_6	330214.NIDE4293	8.238e-72	245.0	COG0001@1|root,COG0001@2|Bacteria,3J0B3@40117|Nitrospirae	40117|Nitrospirae	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
LZS2_k127_4097441_8	330214.NIDE4289	1.527e-41	160.0	COG2732@1|root,COG2732@2|Bacteria	2|Bacteria	K	(Barnase) inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
LZS2_k127_4097441_9	330214.NIDE4288	6.636e-31	127.0	COG4290@1|root,COG4290@2|Bacteria	2|Bacteria	F	endoribonuclease activity	-	GO:0005575,GO:0005576	-	ko:K03628,ko:K15125	ko03018,ko05133,map03018,map05133	-	-	-	ko00000,ko00001,ko00536,ko03019,ko03021	-	-	-	Ribonuclease
LZS2_k127_4097441_4	330214.NIDE4284	1.062e-112	366.0	COG0546@1|root,COG0546@2|Bacteria,3J0QE@40117|Nitrospirae	40117|Nitrospirae	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
LZS2_k127_4097441_1	330214.NIDE4283	2.541e-242	761.0	COG0612@1|root,COG0612@2|Bacteria,3J0BY@40117|Nitrospirae	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
LZS2_k127_4097441_2	330214.NIDE4282	1.819e-212	672.0	COG0612@1|root,COG0612@2|Bacteria,3J0I5@40117|Nitrospirae	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ymxG	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
LZS2_k127_4097441_5	330214.NIDE4281	3.88e-105	347.0	COG0491@1|root,COG1396@1|root,COG0491@2|Bacteria,COG1396@2|Bacteria,3J17T@40117|Nitrospirae	40117|Nitrospirae	K	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
LZS2_k127_4097441_3	330214.NIDE4279	4.32e-132	428.0	COG1994@1|root,COG1994@2|Bacteria,3J0KK@40117|Nitrospirae	40117|Nitrospirae	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
LZS2_k127_4097441_0	1348657.M622_19040	4.742e-292	904.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,2VJSS@28216|Betaproteobacteria	28216|Betaproteobacteria	L	type III restriction protein res subunit	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
LZS2_k127_4122433_2	330214.NIDE3973	3.221e-100	328.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
LZS2_k127_4122433_4	1123060.JONP01000053_gene4965	1.389e-07	53.0	COG0309@1|root,COG0309@2|Bacteria,1RDJ4@1224|Proteobacteria,2U7HE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG3293 Transposase and inactivated derivatives	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
LZS2_k127_4122433_0	1121004.ATVC01000001_gene426	8.365e-201	645.0	COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2VK2V@28216|Betaproteobacteria,2KQU2@206351|Neisseriales	206351|Neisseriales	S	Bacterial protein of unknown function (DUF839)	-	-	-	ko:K07093	-	-	-	-	ko00000	-	-	-	DUF839
LZS2_k127_4122433_3	330214.NIDE3409	3.965e-12	72.0	COG1734@1|root,COG1734@2|Bacteria	2|Bacteria	T	zinc ion binding	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
LZS2_k127_4122433_1	330214.NIDE0858	4.031e-101	334.0	COG0745@1|root,COG0745@2|Bacteria,3J0JU@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
LZS2_k127_4176179_1	717774.Marme_3032	5.501e-12	69.0	COG0666@1|root,COG0666@2|Bacteria,1MVPK@1224|Proteobacteria,1SETM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ankyrin repeats	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Thioredoxin_2
LZS2_k127_4176179_0	1121937.AUHJ01000036_gene2807	2.114e-186	591.0	COG3464@1|root,COG3464@2|Bacteria,1N2V1@1224|Proteobacteria,1RN1I@1236|Gammaproteobacteria,4640P@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
LZS2_k127_4252663_0	330214.NIDE3220	2.746e-139	447.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	rhdA	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
LZS2_k127_4252663_1	330214.NIDE3218	5.404e-128	413.0	COG0388@1|root,COG0388@2|Bacteria,3J11H@40117|Nitrospirae	40117|Nitrospirae	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
LZS2_k127_4252663_3	330214.NIDE3217	8.74e-89	297.0	COG1678@1|root,COG1678@2|Bacteria	2|Bacteria	K	ribonucleoside-diphosphate reductase activity	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
LZS2_k127_4252663_2	330214.NIDE0462	2.005e-127	422.0	COG4949@1|root,COG4949@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3422)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422
LZS2_k127_4262014_7	330214.NIDE1422	2.268e-22	96.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,3J0A2@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
LZS2_k127_4262014_2	330214.NIDE1423	3.057e-119	389.0	COG1187@1|root,COG1187@2|Bacteria,3J0RN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.21,5.4.99.22	ko:K06178,ko:K06181,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
LZS2_k127_4262014_0	330214.NIDE1425	5e-324	999.0	COG0173@1|root,COG0173@2|Bacteria,3J0FR@40117|Nitrospirae	40117|Nitrospirae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
LZS2_k127_4262014_1	330214.NIDE1426	4.844e-205	642.0	COG0082@1|root,COG0082@2|Bacteria,3J0KQ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
LZS2_k127_4262014_6	671143.DAMO_2925	5.094e-30	122.0	COG1993@1|root,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria	2|Bacteria	T	Uncharacterized ACR, COG1993	-	-	-	ko:K06199,ko:K09137	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CBS,DUF190
LZS2_k127_4262014_5	671143.DAMO_2926	3.811e-39	152.0	COG0239@1|root,COG0239@2|Bacteria,2NQ56@2323|unclassified Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
LZS2_k127_4262014_4	330214.NIDE1427	4.815e-82	286.0	COG0328@1|root,COG0328@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	5_3_exonuc,5_3_exonuc_N,RNase_H
LZS2_k127_4262014_3	330214.NIDE1428	6.856e-102	344.0	COG1119@1|root,COG1119@2|Bacteria	2|Bacteria	P	ATPase activity	modF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21,3.6.3.34	ko:K02013,ko:K02028,ko:K05776	ko02010,map02010	M00189,M00236,M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14,3.A.1.3	-	-	ABC_tran
LZS2_k127_426752_1	330214.NIDE4184	4.345e-105	346.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_426752_2	330214.NIDE0169	2.58e-66	229.0	COG0359@1|root,COG0359@2|Bacteria,3J0MQ@40117|Nitrospirae	40117|Nitrospirae	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
LZS2_k127_426752_0	330214.NIDE0168	1.79e-235	737.0	COG0112@1|root,COG0112@2|Bacteria,3J0CB@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
LZS2_k127_426752_3	330214.NIDE0167	1.423e-64	224.0	COG1327@1|root,COG1327@2|Bacteria,3J14C@40117|Nitrospirae	40117|Nitrospirae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
LZS2_k127_43311_1	1406840.Q763_06375	1.125e-56	207.0	COG0644@1|root,COG0644@2|Bacteria,4NE67@976|Bacteroidetes,1HYEN@117743|Flavobacteriia,2NTJI@237|Flavobacterium	976|Bacteroidetes	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl,SE,Trp_halogenase
LZS2_k127_43311_0	396588.Tgr7_3069	1.506e-79	271.0	COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,1S4QY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase membrane zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
LZS2_k127_43311_2	1162668.LFE_0747	4.202e-37	153.0	COG0681@1|root,COG0681@2|Bacteria,3J0IP@40117|Nitrospirae	40117|Nitrospirae	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
LZS2_k127_43311_3	1216976.AX27061_5375	9.347e-17	87.0	COG3300@1|root,COG5001@1|root,COG3300@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,3T305@506|Alcaligenaceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	gmr	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,MHYT
LZS2_k127_4388510_0	330214.NIDE3165	0.0	1203.0	COG2183@1|root,COG2183@2|Bacteria	2|Bacteria	K	obsolete transcription factor activity, core RNA polymerase II binding	yhgF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
LZS2_k127_4388510_2	330214.NIDE2082	2.178e-58	211.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_5,CHAP,NLPC_P60
LZS2_k127_4388510_1	330214.NIDE2454	3.385e-267	827.0	COG0114@1|root,COG0114@2|Bacteria,3J0FU@40117|Nitrospirae	40117|Nitrospirae	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
LZS2_k127_4478621_1	1123073.KB899243_gene474	8.596e-85	282.0	COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,1S252@1236|Gammaproteobacteria,1X6BN@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1348)	-	-	-	ko:K09958	-	-	-	-	ko00000	-	-	-	DUF1348
LZS2_k127_4478621_0	290397.Adeh_0548	1.887e-144	464.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,42SZ5@68525|delta/epsilon subdivisions,2WPP5@28221|Deltaproteobacteria,2YZUG@29|Myxococcales	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
LZS2_k127_4478621_3	1484460.JSWG01000009_gene324	3.746e-20	94.0	COG3631@1|root,COG3631@2|Bacteria,4NUVF@976|Bacteroidetes,1I63Y@117743|Flavobacteriia	976|Bacteroidetes	S	Ketosteroid isomerase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4478621_2	1502850.FG91_02597	5.969e-72	245.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,2U17G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
LZS2_k127_4498651_2	330214.NIDE2405	9e-26	108.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,3J17M@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K07114,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,VWA_2
LZS2_k127_4498651_0	330214.NIDE2404	1.786e-193	617.0	COG0472@1|root,COG0472@2|Bacteria	2|Bacteria	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	wecA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.33,2.7.8.35,5.1.3.14	ko:K01791,ko:K02851	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R08856	RC00002,RC00290	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	-	iAF987.Gmet_1505,iECSF_1327.ECSF_3624	Glycos_transf_4
LZS2_k127_4498651_1	330214.NIDE2403	1.445e-146	474.0	COG1269@1|root,COG1269@2|Bacteria,3J156@40117|Nitrospirae	2|Bacteria	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH,Peptidase_M28
LZS2_k127_4513607_1	330214.NIDE4245	3.033e-85	286.0	COG1595@1|root,COG1595@2|Bacteria,3J1A1@40117|Nitrospirae	40117|Nitrospirae	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_4513607_3	330214.NIDE4246	2.141e-26	112.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
LZS2_k127_451473_1	330214.NIDE0628	8.729e-05	50.0	COG0810@1|root,COG0810@2|Bacteria,3J0U0@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
LZS2_k127_451473_0	330214.NIDE0631	2.374e-87	299.0	COG4313@1|root,COG4313@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4521897_3	330214.NIDE2209	3.928e-166	533.0	COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
LZS2_k127_4521897_4	330214.NIDE2210	1.593e-123	407.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	-	-	2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4	ko:K00543,ko:K16130,ko:K18896,ko:K18897,ko:K21515	ko00260,ko00380,ko01054,ko01100,map00260,map00380,map01054,map01100	M00037	R03130,R04905,R10060,R10061	RC00003,RC00392,RC03038,RC03040	ko00000,ko00001,ko00002,ko01000,ko01008,ko03009	-	-	-	AMP-binding,Aminotran_1_2,AviRa,Condensation,Dimerisation2,Hen1_L,Methyltransf_12,Methyltransf_2,Methyltransf_23,Methyltransf_25,Methyltransf_31,PP-binding
LZS2_k127_4521897_2	330214.NIDE0590	1.661e-182	574.0	COG3733@1|root,COG3733@2|Bacteria	2|Bacteria	Q	amine oxidase	-	-	1.4.3.21	ko:K00276	ko00260,ko00350,ko00360,ko00410,ko00950,ko00960,ko01100,ko01110,map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110	-	R02382,R02529,R02613,R03139,R04027,R04300,R06154,R06740	RC00062,RC00189,RC00676,RC01052	ko00000,ko00001,ko01000	-	-	-	Cu_amine_oxid
LZS2_k127_4521897_10	204773.HEAR1371	6.556e-57	203.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria,4778E@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
LZS2_k127_4521897_0	330214.NIDE1420	0.0	1724.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,PA14
LZS2_k127_4521897_1	330214.NIDE1421	1.117e-266	831.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
LZS2_k127_4521897_5	330214.NIDE1422	3.47e-105	346.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,3J0A2@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
LZS2_k127_4522037_1	330214.NIDE1676	1.839e-241	751.0	COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae	40117|Nitrospirae	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
LZS2_k127_4522037_15	330214.NIDE1677	4.842e-73	256.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
LZS2_k127_4522037_17	330214.NIDE1678	1.813e-57	209.0	COG1214@1|root,COG1214@2|Bacteria,3J0VU@40117|Nitrospirae	40117|Nitrospirae	O	Glycoprotease family	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
LZS2_k127_4522037_22	330214.NIDE1679	4.347e-44	171.0	COG0454@1|root,COG0456@2|Bacteria,3J1CI@40117|Nitrospirae	40117|Nitrospirae	K	Acetyltransferase (GNAT) domain	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
LZS2_k127_4522037_23	330214.NIDE1680	2.65e-20	93.0	2DRP0@1|root,33CFM@2|Bacteria,3J1BN@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
LZS2_k127_4522037_8	330214.NIDE1681	6.893e-113	369.0	COG0805@1|root,COG0805@2|Bacteria,3J0PJ@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
LZS2_k127_4522037_6	330214.NIDE1682	3.483e-125	411.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
LZS2_k127_4522037_11	330214.NIDE1683	8.531e-85	284.0	COG0652@1|root,COG0652@2|Bacteria,3J18H@40117|Nitrospirae	40117|Nitrospirae	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
LZS2_k127_4522037_16	479434.Sthe_2625	5.482e-67	241.0	COG1216@1|root,COG1216@2|Bacteria,2G69V@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
LZS2_k127_4522037_2	330214.NIDE2455	8.263e-228	711.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	preT	-	1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00528,ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R10159,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3
LZS2_k127_4522037_4	330214.NIDE2456	8.151e-140	449.0	COG0061@1|root,COG0061@2|Bacteria,3J0HS@40117|Nitrospirae	40117|Nitrospirae	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
LZS2_k127_4522037_0	330214.NIDE2457	0.0	1500.0	COG0542@1|root,COG0542@2|Bacteria,3J0B4@40117|Nitrospirae	40117|Nitrospirae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
LZS2_k127_4522037_7	330214.NIDE2458	2.143e-116	386.0	COG0533@1|root,COG0533@2|Bacteria,3J0I3@40117|Nitrospirae	40117|Nitrospirae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
LZS2_k127_4522037_3	330214.NIDE2459	8.609e-203	645.0	COG2262@1|root,COG2262@2|Bacteria,3J0AE@40117|Nitrospirae	40117|Nitrospirae	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
LZS2_k127_4522037_12	330214.NIDE2460	2.859e-84	284.0	COG0177@1|root,COG0177@2|Bacteria,3J0K6@40117|Nitrospirae	40117|Nitrospirae	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
LZS2_k127_4522037_9	330214.NIDE2461	1.071e-97	327.0	COG1561@1|root,COG1561@2|Bacteria,3J0QJ@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
LZS2_k127_4522037_13	330214.NIDE2462	7.695e-82	278.0	COG0194@1|root,COG0194@2|Bacteria,3J0JT@40117|Nitrospirae	40117|Nitrospirae	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
LZS2_k127_4522037_21	330214.NIDE2463	2.957e-46	169.0	COG1758@1|root,COG1758@2|Bacteria,3J0UJ@40117|Nitrospirae	40117|Nitrospirae	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
LZS2_k127_4522037_5	330214.NIDE2464	1.621e-139	454.0	COG0452@1|root,COG0452@2|Bacteria,3J0GK@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
LZS2_k127_4522037_20	330214.NIDE2465	5.771e-47	177.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	2.7.11.1	ko:K14949,ko:K20543	ko05152,map05152	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	1.B.55.3	-	-	DUF560,EcsC,Glyco_transf_41,HyaE,NfrA_C,Sulfotransfer_3,TPR_16
LZS2_k127_4522037_18	330214.NIDE2466	2.811e-56	201.0	COG0757@1|root,COG0757@2|Bacteria,3J199@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
LZS2_k127_4522037_10	330214.NIDE2467	3.606e-96	316.0	COG0231@1|root,COG0231@2|Bacteria,3J0JC@40117|Nitrospirae	40117|Nitrospirae	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
LZS2_k127_4522037_19	330214.NIDE2468	3.811e-53	195.0	COG0511@1|root,COG0511@2|Bacteria,3J0PI@40117|Nitrospirae	40117|Nitrospirae	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
LZS2_k127_4532111_6	1380391.JIAS01000011_gene4856	6.356e-09	57.0	COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,2U8J8@28211|Alphaproteobacteria,2JXS8@204441|Rhodospirillales	204441|Rhodospirillales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4532111_0	272624.lpg0247	1.767e-88	302.0	2BVG0@1|root,32QV2@2|Bacteria,1QN3M@1224|Proteobacteria,1TKHB@1236|Gammaproteobacteria,1JDZA@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4532111_2	595537.Varpa_5255	2.914e-80	270.0	COG3832@1|root,COG3832@2|Bacteria,1RCZK@1224|Proteobacteria,2VR7G@28216|Betaproteobacteria,4ADZG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
LZS2_k127_4532111_3	1144275.COCOR_01922	9.226e-76	257.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,42QW0@68525|delta/epsilon subdivisions,2WMZW@28221|Deltaproteobacteria,2YV61@29|Myxococcales	28221|Deltaproteobacteria	H	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
LZS2_k127_4532111_4	1353531.AZNX01000001_gene2297	2.155e-73	251.0	COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2U7DU@28211|Alphaproteobacteria,4BEH0@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
LZS2_k127_4532111_1	1380391.JIAS01000011_gene4922	8.931e-86	287.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,2JQPM@204441|Rhodospirillales	204441|Rhodospirillales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
LZS2_k127_4532111_5	1502851.FG93_04366	1.182e-63	221.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2U735@28211|Alphaproteobacteria,3JZ56@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
LZS2_k127_4533072_6	330214.NIDE4396	3.464e-151	482.0	COG1351@1|root,COG1351@2|Bacteria	2|Bacteria	F	thymidylate synthase (FAD) activity	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
LZS2_k127_4533072_5	330214.NIDE4397	1.106e-184	586.0	COG0124@1|root,COG0124@2|Bacteria,3J0EC@40117|Nitrospirae	40117|Nitrospirae	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
LZS2_k127_4533072_13	330214.NIDE4398	4.248e-30	122.0	COG1553@1|root,COG1553@2|Bacteria,3J1AA@40117|Nitrospirae	40117|Nitrospirae	P	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4533072_3	330214.NIDE0001	2.124e-227	710.0	COG0593@1|root,COG0593@2|Bacteria,3J0FQ@40117|Nitrospirae	40117|Nitrospirae	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
LZS2_k127_4533072_4	330214.NIDE0002	1.714e-199	626.0	COG0592@1|root,COG0592@2|Bacteria,3J0RU@40117|Nitrospirae	40117|Nitrospirae	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
LZS2_k127_4533072_1	243231.GSU0003	4.246e-296	929.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43U22@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
LZS2_k127_4533072_0	330214.NIDE0004	0.0	1398.0	COG0188@1|root,COG0188@2|Bacteria,3J0EH@40117|Nitrospirae	40117|Nitrospirae	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
LZS2_k127_4533072_12	330214.NIDE0006	2.589e-38	149.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
LZS2_k127_4533072_9	330214.NIDE0007	5.633e-79	266.0	COG0691@1|root,COG0691@2|Bacteria,3J0Q4@40117|Nitrospirae	40117|Nitrospirae	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
LZS2_k127_4533072_7	330214.NIDE1563	4.35e-146	479.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	cpxA	-	2.7.13.3	ko:K02484,ko:K07640,ko:K07643,ko:K07645,ko:K07649,ko:K19609	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00447,M00451,M00453,M00457,M00721,M00722,M00727,M00728,M00770	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,CpxA_peri,HAMP,HATPase_c,HK_sensor,HisKA
LZS2_k127_4533072_8	330214.NIDE1562	1.205e-109	358.0	COG0745@1|root,COG0745@2|Bacteria,3J11I@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
LZS2_k127_4533072_15	648996.Theam_0086	4.505e-07	60.0	2DPW1@1|root,333MM@2|Bacteria,2G50H@200783|Aquificae	200783|Aquificae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4533072_10	330214.NIDE3565	5.431e-69	237.0	COG4802@1|root,COG4802@2|Bacteria	2|Bacteria	C	ferredoxin-thioredoxin reductase activity	ftrC	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015979,GO:0016491,GO:0016730,GO:0022900,GO:0030385,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	1.8.7.2	ko:K17892	-	-	-	-	ko00000,ko01000	-	-	-	FeThRed_B
LZS2_k127_4533072_2	330214.NIDE3564	1.276e-263	841.0	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
LZS2_k127_4537335_2	1288494.EBAPG3_12230	5.701e-42	156.0	COG0385@1|root,COG0385@2|Bacteria,1PWDU@1224|Proteobacteria,2WBYI@28216|Betaproteobacteria,3740W@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Sodium Bile acid symporter family	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	-
LZS2_k127_4537335_0	1036674.A28LD_1573	6.602e-94	312.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
LZS2_k127_4537335_3	1192124.LIG30_0174	6.505e-22	111.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1K0RA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Protoglobin,Response_reg,dCache_3
LZS2_k127_4537335_1	330214.NIDE3941	3.855e-67	249.0	COG2202@1|root,COG3290@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,3J124@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
LZS2_k127_4537335_4	330214.NIDE3940	5.562e-14	78.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE3940|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4553140_4	330214.NIDE2301	2.034e-12	71.0	COG3190@1|root,COG3190@2|Bacteria	2|Bacteria	N	flagellar	fliP	-	-	ko:K02418,ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO,FliP
LZS2_k127_4553140_3	330214.NIDE2300	3.878e-36	140.0	COG1886@1|root,COG1886@2|Bacteria,3J0QM@40117|Nitrospirae	40117|Nitrospirae	N	Type III flagellar switch regulator (C-ring) FliN C-term	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
LZS2_k127_4553140_0	330214.NIDE2299	6.234e-146	468.0	COG1868@1|root,COG1868@2|Bacteria,3J0CU@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
LZS2_k127_4553140_2	330214.NIDE2298	8.314e-40	154.0	COG1580@1|root,COG1580@2|Bacteria,3J0QH@40117|Nitrospirae	40117|Nitrospirae	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
LZS2_k127_4553140_1	330214.NIDE2297	9.695e-112	376.0	COG1749@1|root,COG1749@2|Bacteria,3J0IF@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar basal body protein FlaE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
LZS2_k127_4576269_2	330214.NIDE1105	2.369e-41	156.0	COG0149@1|root,COG0149@2|Bacteria,3J0MW@40117|Nitrospirae	40117|Nitrospirae	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
LZS2_k127_4576269_0	330214.NIDE1106	6.331e-220	686.0	COG0126@1|root,COG0126@2|Bacteria,3J0DE@40117|Nitrospirae	40117|Nitrospirae	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
LZS2_k127_4576269_1	330214.NIDE1107	2.24e-44	162.0	COG0057@1|root,COG0057@2|Bacteria,3J0D8@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
LZS2_k127_4576692_2	330214.NIDE3363	1.897e-61	217.0	COG0811@1|root,COG0811@2|Bacteria,3J0PX@40117|Nitrospirae	40117|Nitrospirae	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
LZS2_k127_4576692_4	1340434.AXVA01000023_gene3392	0.0007	43.0	2EHF3@1|root,33B70@2|Bacteria,1VP4D@1239|Firmicutes,4IM7K@91061|Bacilli,1ZK47@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4576692_0	330214.NIDE3364	1.248e-85	295.0	COG4974@1|root,COG4974@2|Bacteria,3J0KV@40117|Nitrospirae	40117|Nitrospirae	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
LZS2_k127_4576692_1	330214.NIDE3365	5.061e-64	228.0	COG0683@1|root,COG0683@2|Bacteria,3J18U@40117|Nitrospirae	40117|Nitrospirae	E	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
LZS2_k127_4647212_4	330214.NIDE2593	0.0003156	48.0	2DCFZ@1|root,2ZDZV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4647212_0	330214.NIDE2530	5.564e-89	305.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
LZS2_k127_4647212_2	330214.NIDE2529	1.304e-32	133.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,NB-ARC,PG_binding_1,TPR_10,TniB
LZS2_k127_4691148_1	330214.NIDE2194	1.701e-62	219.0	COG1533@1|root,COG1533@2|Bacteria,3J0QV@40117|Nitrospirae	40117|Nitrospirae	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
LZS2_k127_4691148_2	261292.Nit79A3_1082	1.267e-56	199.0	COG0607@1|root,COG0607@2|Bacteria,1PE8D@1224|Proteobacteria,2WC5X@28216|Betaproteobacteria,374CH@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
LZS2_k127_4691148_0	330214.NIDE2197	3.753e-69	239.0	COG2825@1|root,COG2825@2|Bacteria,3J1AH@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
LZS2_k127_4696968_7	330214.NIDE1102	6.665e-41	153.0	COG0261@1|root,COG0261@2|Bacteria,3J0TM@40117|Nitrospirae	40117|Nitrospirae	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
LZS2_k127_4696968_5	330214.NIDE1101	2.504e-42	156.0	COG0211@1|root,COG0211@2|Bacteria,3J0RB@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
LZS2_k127_4696968_3	1123376.AUIU01000016_gene303	2.716e-118	391.0	COG0536@1|root,COG0536@2|Bacteria,3J0E3@40117|Nitrospirae	40117|Nitrospirae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
LZS2_k127_4696968_1	330214.NIDE1099	1.732e-180	571.0	COG0263@1|root,COG0263@2|Bacteria,3J0GU@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
LZS2_k127_4696968_4	330214.NIDE1098	1.288e-74	258.0	COG1057@1|root,COG1057@2|Bacteria,3J0T3@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
LZS2_k127_4696968_6	330214.NIDE1097	1.251e-41	157.0	COG0799@1|root,COG0799@2|Bacteria,3J0UC@40117|Nitrospirae	40117|Nitrospirae	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
LZS2_k127_4696968_0	330214.NIDE1096	1.37e-233	729.0	COG2956@1|root,COG2956@2|Bacteria,3J0KC@40117|Nitrospirae	40117|Nitrospirae	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
LZS2_k127_4696968_2	330214.NIDE1095	2.66e-163	520.0	COG0502@1|root,COG0502@2|Bacteria,3J0I9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
LZS2_k127_4696968_10	330214.NIDE1693	4.952e-18	88.0	COG4185@1|root,COG4185@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
LZS2_k127_4696968_8	398767.Glov_2141	5.926e-32	129.0	COG4185@1|root,COG4185@2|Bacteria,1RFDC@1224|Proteobacteria,42TT0@68525|delta/epsilon subdivisions,2WQEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
LZS2_k127_4696968_9	247490.KSU1_C0280	7.81e-19	98.0	2BRMQ@1|root,32KM4@2|Bacteria,2J4AR@203682|Planctomycetes	247490.KSU1_C0280|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4696968_12	479432.Sros_3497	0.0003834	46.0	COG1404@1|root,COG1404@2|Bacteria,2HEJ5@201174|Actinobacteria,4EHUI@85012|Streptosporangiales	201174|Actinobacteria	O	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Malectin,Peptidase_S8
LZS2_k127_4696968_11	1499967.BAYZ01000176_gene5676	1.039e-07	62.0	COG4916@1|root,COG4916@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
LZS2_k127_4783997_11	930169.B5T_03152	1.713e-19	92.0	COG3784@1|root,COG3784@2|Bacteria,1N6R1@1224|Proteobacteria,1SC8V@1236|Gammaproteobacteria,1XM2K@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09978	-	-	-	-	ko00000	-	-	-	DUF1318
LZS2_k127_4783997_12	1121403.AUCV01000008_gene1536	8.707e-17	82.0	2E371@1|root,32Y6T@2|Bacteria	2|Bacteria	S	Lipoprotein	ynbE	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_19
LZS2_k127_4783997_8	1182590.BN5_02904	1.676e-27	131.0	COG2911@1|root,COG2911@2|Bacteria,1QDYT@1224|Proteobacteria,1TA71@1236|Gammaproteobacteria,1YEFH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Dicarboxylate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctA-YdbH
LZS2_k127_4783997_9	330214.NIDE1139	2.192e-26	109.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,DUF3565
LZS2_k127_4783997_6	330214.NIDE1136	4.009e-65	228.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	hbpS	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
LZS2_k127_4783997_1	330214.NIDE1132	2.51e-276	863.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
LZS2_k127_4783997_0	330214.NIDE1131	0.0	1525.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
LZS2_k127_4783997_4	330214.NIDE1129	8.65e-132	428.0	COG4677@1|root,COG4677@2|Bacteria	2|Bacteria	G	pectinesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Lipase_GDSL_2,NosD,Pectate_lyase_3
LZS2_k127_4783997_5	330214.NIDE1128	1.128e-78	267.0	COG0237@1|root,COG0237@2|Bacteria,3J0RK@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
LZS2_k127_4783997_3	330214.NIDE1127	9.459e-158	502.0	COG0492@1|root,COG0492@2|Bacteria,3J0M0@40117|Nitrospirae	40117|Nitrospirae	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
LZS2_k127_4783997_2	330214.NIDE1125	9.744e-163	521.0	COG0301@1|root,COG0301@2|Bacteria	2|Bacteria	H	tRNA thio-modification	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
LZS2_k127_4787150_0	1242864.D187_003782	2.063e-194	627.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
LZS2_k127_4787150_1	1144275.COCOR_05577	2.336e-99	344.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
LZS2_k127_4787150_2	269799.Gmet_3367	7.828e-49	180.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
LZS2_k127_4792840_18	1227500.C494_01452	2.344e-06	61.0	arCOG09161@1|root,arCOG09161@2157|Archaea,2XTSA@28890|Euryarchaeota,23T8C@183963|Halobacteria	183963|Halobacteria	S	xylanase chitin deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
LZS2_k127_4792840_16	908338.HMPREF9286_0088	7.357e-19	100.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,22G10@1570339|Peptoniphilaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
LZS2_k127_4792840_17	267608.RSc0559	1.702e-07	64.0	COG3307@1|root,COG3307@2|Bacteria,1RA1F@1224|Proteobacteria,2VQ8F@28216|Betaproteobacteria,1K2C4@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Pfam O-Antigen Polymerase	-	-	-	-	-	-	-	-	-	-	-	-	PglL_A,Wzy_C,Wzy_C_2
LZS2_k127_4792840_7	857087.Metme_0411	5.102e-92	318.0	COG0438@1|root,COG0438@2|Bacteria,1NC1U@1224|Proteobacteria,1SP3Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
LZS2_k127_4792840_14	240292.Ava_1042	2.596e-52	195.0	COG1216@1|root,COG1216@2|Bacteria,1G2TX@1117|Cyanobacteria	1117|Cyanobacteria	Q	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4792840_6	717785.HYPMC_3134	2.723e-98	336.0	COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2U1NW@28211|Alphaproteobacteria,3N8M7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
LZS2_k127_4792840_13	324925.Ppha_0562	1.31e-64	225.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wcaF	-	2.3.1.79	ko:K00661,ko:K03818	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
LZS2_k127_4792840_11	1317124.DW2_18039	3.15e-84	284.0	COG2227@1|root,COG2227@2|Bacteria,1RAQ6@1224|Proteobacteria,2U62S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Mycolic acid cyclopropane synthetase	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
LZS2_k127_4792840_10	675812.VHA_003278	6.799e-86	294.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,1RQUH@1236|Gammaproteobacteria,1Y1EH@135623|Vibrionales	135623|Vibrionales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS2_k127_4792840_4	243233.MCA1168	1.445e-126	418.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,1RS9J@1236|Gammaproteobacteria,1XFU5@135618|Methylococcales	135618|Methylococcales	H	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
LZS2_k127_4792840_15	857087.Metme_0417	1.875e-46	180.0	2BJM8@1|root,32DYJ@2|Bacteria,1QTAB@1224|Proteobacteria,1SUJI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4792840_2	330214.NIDE2403	7.373e-160	520.0	COG1269@1|root,COG1269@2|Bacteria,3J156@40117|Nitrospirae	2|Bacteria	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH,Peptidase_M28
LZS2_k127_4792840_3	330214.NIDE2404	1.361e-136	452.0	COG0472@1|root,COG0472@2|Bacteria	2|Bacteria	M	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	wecA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.33,2.7.8.35,5.1.3.14	ko:K01791,ko:K02851	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R08856	RC00002,RC00290	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	-	iAF987.Gmet_1505,iECSF_1327.ECSF_3624	Glycos_transf_4
LZS2_k127_4792840_0	330214.NIDE2405	2.488e-191	629.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,3J17M@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K07114,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,VWA_2
LZS2_k127_4792840_12	330214.NIDE2406	3.032e-66	234.0	COG1596@1|root,COG1596@2|Bacteria,3J17R@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
LZS2_k127_4792840_8	330214.NIDE2407	1.5e-86	301.0	COG5338@1|root,COG5338@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2,CarbopepD_reg_2,DUF560,Plug
LZS2_k127_4792840_1	330214.NIDE2408	1.06e-182	589.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K07011,ko:K16706	-	-	-	-	ko00000	-	-	-	GNVR,Wzz
LZS2_k127_4792840_9	330214.NIDE2409	2.599e-86	293.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	epsB	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA
LZS2_k127_4792840_5	330214.NIDE2411	2.651e-107	364.0	COG0457@1|root,COG3267@1|root,COG0457@2|Bacteria,COG3267@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
LZS2_k127_4793238_1	1173023.KE650771_gene2604	4.199e-273	850.0	COG0028@1|root,COG0028@2|Bacteria,1G0KQ@1117|Cyanobacteria,1JJ9X@1189|Stigonemataceae	1117|Cyanobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
LZS2_k127_4793238_13	378806.STAUR_6602	3.889e-59	211.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,2YVDJ@29|Myxococcales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
LZS2_k127_4793238_8	330214.NIDE0964	2.801e-89	309.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0964|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4793238_2	330214.NIDE1585	1.67e-241	754.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	2|Bacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_4793238_7	330214.NIDE1584	8.564e-126	413.0	COG3437@1|root,COG3437@2|Bacteria,3J0ID@40117|Nitrospirae	2|Bacteria	T	response regulator	MA20_23615	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
LZS2_k127_4793238_3	330214.NIDE1583	3.48e-164	535.0	COG0497@1|root,COG0497@2|Bacteria,3J0HU@40117|Nitrospirae	40117|Nitrospirae	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
LZS2_k127_4793238_12	330214.NIDE1582	2.509e-63	219.0	COG3118@1|root,COG3118@2|Bacteria,3J0P6@40117|Nitrospirae	40117|Nitrospirae	O	Thioredoxin-like domain	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
LZS2_k127_4793238_0	330214.NIDE1580	0.0	1067.0	COG1452@1|root,COG1452@2|Bacteria,3J0QI@40117|Nitrospirae	40117|Nitrospirae	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
LZS2_k127_4793238_5	330214.NIDE1579	4.393e-152	493.0	COG0285@1|root,COG0285@2|Bacteria,3J0I6@40117|Nitrospirae	40117|Nitrospirae	H	Mur ligase middle domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
LZS2_k127_4793238_4	330214.NIDE1577	1.231e-154	490.0	COG0777@1|root,COG0777@2|Bacteria,3J0CK@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
LZS2_k127_4793238_10	330214.NIDE1575	1.984e-70	245.0	COG2215@1|root,COG2215@2|Bacteria	2|Bacteria	O	Belongs to the NiCoT transporter (TC 2.A.52) family	ureH	-	-	-	-	-	-	-	-	-	-	-	DsbD_2,NicO
LZS2_k127_4793238_6	330214.NIDE1574	1.727e-141	458.0	COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
LZS2_k127_4793238_11	330214.NIDE1573	1.698e-67	236.0	COG0314@1|root,COG0314@2|Bacteria,3J1AN@40117|Nitrospirae	40117|Nitrospirae	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
LZS2_k127_4793238_14	330214.NIDE1572	3.068e-29	125.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS2_k127_4793238_9	330214.NIDE1571	1.917e-84	283.0	COG0315@1|root,COG0315@2|Bacteria,3J0PN@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
LZS2_k127_4793238_16	366602.Caul_0340	1.777e-07	56.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria,2KIPY@204458|Caulobacterales	204458|Caulobacterales	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
LZS2_k127_4793238_15	1121889.AUDM01000026_gene28	4.596e-08	56.0	COG1345@1|root,COG2911@1|root,COG3291@1|root,COG4733@1|root,COG4932@1|root,COG1345@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,4NGSK@976|Bacteroidetes,1HXWK@117743|Flavobacteriia,2P0S4@237|Flavobacterium	976|Bacteroidetes	N	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
LZS2_k127_4799587_2	857087.Metme_4550	1.7e-59	219.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,1RQDH@1236|Gammaproteobacteria,1XE8V@135618|Methylococcales	135618|Methylococcales	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
LZS2_k127_4799587_3	330214.NIDE2437	7.178e-49	183.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE2437|-	T	phosphorelay signal transduction system	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	-
LZS2_k127_4799587_6	330214.NIDE2438	8.586e-13	72.0	COG2905@1|root,COG2905@2|Bacteria,3J0UW@40117|Nitrospirae	40117|Nitrospirae	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
LZS2_k127_4799587_1	864051.BurJ1DRAFT_0964	1.132e-131	438.0	COG4222@1|root,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,2VJBV@28216|Betaproteobacteria,1KMPZ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Esterase-like activity of phytase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	Phytase-like
LZS2_k127_4799587_0	67352.JODS01000024_gene3009	7.193e-251	808.0	COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria	201174|Actinobacteria	M	endonuclease exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Exo_endo_phos,LTD
LZS2_k127_4799587_4	3988.XP_002534676.1	3.311e-21	102.0	COG2374@1|root,2QV0U@2759|Eukaryota,382YS@33090|Viridiplantae	33090|Viridiplantae	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_481791_2	330214.NIDE4392	4.242e-13	69.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS2_k127_4844992_6	765913.ThidrDRAFT_3902	1.044e-12	79.0	COG3475@1|root,COG3475@2|Bacteria,1NI2D@1224|Proteobacteria,1TKC2@1236|Gammaproteobacteria,1X1RH@135613|Chromatiales	135613|Chromatiales	M	LICD family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4844992_4	330214.NIDE3982	8.979e-29	121.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
LZS2_k127_4844992_8	443144.GM21_0228	3.998e-09	60.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43UDA@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	degP	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
LZS2_k127_4844992_2	330214.NIDE3247	9.92e-72	249.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
LZS2_k127_4844992_1	118163.Ple7327_0190	3.215e-78	296.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria,3VHNF@52604|Pleurocapsales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
LZS2_k127_4844992_0	330214.NIDE3821	2.339e-106	355.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
LZS2_k127_484737_2	330214.NIDE0960	6.613e-230	720.0	COG4122@1|root,COG4122@2|Bacteria,3J0XW@40117|Nitrospirae	40117|Nitrospirae	S	Pup-ligase protein	-	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
LZS2_k127_484737_6	330214.NIDE0959	3.083e-91	307.0	COG0638@1|root,COG0638@2|Bacteria,3J15S@40117|Nitrospirae	40117|Nitrospirae	O	Proteasome subunit	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
LZS2_k127_484737_4	330214.NIDE0958	1.155e-133	429.0	COG0638@1|root,COG0638@2|Bacteria,3J11F@40117|Nitrospirae	40117|Nitrospirae	O	Proteasome subunit	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
LZS2_k127_484737_10	330214.NIDE0957	5.716e-22	96.0	2ERDX@1|root,33IZH@2|Bacteria	2|Bacteria	S	May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes	ubact	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_484737_1	330214.NIDE0956	1.777e-265	824.0	COG4122@1|root,COG4122@2|Bacteria,3J0ZW@40117|Nitrospirae	40117|Nitrospirae	S	Pup-ligase protein	-	-	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
LZS2_k127_484737_0	330214.NIDE0955	4.581e-276	858.0	COG1222@1|root,COG1222@2|Bacteria,3J0Z7@40117|Nitrospirae	40117|Nitrospirae	O	Proteasomal ATPase OB/ID domain	-	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
LZS2_k127_484737_3	330214.NIDE0954	5.278e-165	530.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	2|Bacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	degP	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
LZS2_k127_484737_8	330214.NIDE0953	4.992e-49	179.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
LZS2_k127_484737_5	330214.NIDE0952	1.827e-115	380.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko02048	-	-	-	HD
LZS2_k127_484737_9	330214.NIDE0950	1.609e-39	153.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HIT
LZS2_k127_4868861_5	1123373.ATXI01000023_gene1791	0.0004873	46.0	2ENUW@1|root,33GFZ@2|Bacteria,2GI0K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
LZS2_k127_4868861_2	330214.NIDE1430	5.941e-26	115.0	COG3065@1|root,COG3065@2|Bacteria,3J1BB@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
LZS2_k127_4868861_1	335283.Neut_2352	1.854e-27	117.0	COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,2VT3J@28216|Betaproteobacteria,3730X@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
LZS2_k127_4868861_0	153948.NAL212_1039	8.945e-34	137.0	2BP06@1|root,32HQG@2|Bacteria,1RK5Z@1224|Proteobacteria,2WBIA@28216|Betaproteobacteria,3736M@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4868861_3	105559.Nwat_1666	2e-19	95.0	29A8R@1|root,2ZX9N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4868861_4	640511.BC1002_1950	1.256e-07	55.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,2VXNN@28216|Betaproteobacteria,1KAB0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
LZS2_k127_4887953_1	926550.CLDAP_27810	3.806e-56	208.0	COG1216@1|root,COG1216@2|Bacteria,2G8DR@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
LZS2_k127_4887953_0	1267535.KB906767_gene4085	1.692e-179	569.0	COG1015@1|root,COG1015@2|Bacteria,3Y6GB@57723|Acidobacteria	57723|Acidobacteria	G	Metalloenzyme superfamily	-	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
LZS2_k127_4887953_2	867845.KI911784_gene2895	5.078e-33	141.0	COG0438@1|root,COG0438@2|Bacteria,2GAC5@200795|Chloroflexi,376TE@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS2_k127_4952862_1	269799.Gmet_1218	1.674e-64	247.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2X7KX@28221|Deltaproteobacteria,43T3C@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4
LZS2_k127_4952862_2	118168.MC7420_5911	7.963e-24	118.0	COG2114@1|root,COG2203@1|root,COG5000@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG5000@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	GAF,Guanylate_cyc,PAS_3,PAS_4,PAS_9,Response_reg
LZS2_k127_4952862_3	330214.NIDE3808	5.762e-15	74.0	COG0719@1|root,COG0719@2|Bacteria,3J1E6@40117|Nitrospirae	40117|Nitrospirae	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
LZS2_k127_4952862_0	330214.NIDE1953	2.108e-268	837.0	COG2831@1|root,COG2831@2|Bacteria	2|Bacteria	U	hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF285,POTRA_2,ShlB
LZS2_k127_4952862_4	909663.KI867149_gene3337	1.446e-06	53.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Integrase catalytic	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
LZS2_k127_4959168_0	330214.NIDE4158	2.063e-310	965.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,3J0DP@40117|Nitrospirae	40117|Nitrospirae	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
LZS2_k127_4959168_1	261292.Nit79A3_1596	1.418e-53	191.0	2E4SV@1|root,32ZM7@2|Bacteria,1N8VN@1224|Proteobacteria,2WBIK@28216|Betaproteobacteria,373EN@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
LZS2_k127_4980126_1	330214.NIDE0541	3.848e-119	387.0	COG3145@1|root,COG3145@2|Bacteria	2|Bacteria	L	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
LZS2_k127_4980126_2	330214.NIDE0540	6.878e-91	307.0	COG2834@1|root,COG2834@2|Bacteria,3J1C6@40117|Nitrospirae	40117|Nitrospirae	M	Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
LZS2_k127_4980126_0	330214.NIDE0539	2.468e-272	851.0	COG1674@1|root,COG1674@2|Bacteria,3J0BQ@40117|Nitrospirae	40117|Nitrospirae	D	Ftsk_gamma	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
LZS2_k127_4998287_21	330214.NIDE3046	1.05e-39	149.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
LZS2_k127_4998287_4	330214.NIDE3045	2.734e-150	479.0	COG1210@1|root,COG1210@2|Bacteria,3J0B2@40117|Nitrospirae	40117|Nitrospirae	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
LZS2_k127_4998287_0	330214.NIDE3044	0.0	1086.0	COG4775@1|root,COG4775@2|Bacteria,3J0AC@40117|Nitrospirae	40117|Nitrospirae	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
LZS2_k127_4998287_16	330214.NIDE3043	2.429e-59	214.0	COG2825@1|root,COG2825@2|Bacteria,3J1AH@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
LZS2_k127_4998287_19	330214.NIDE3042	8.18e-47	175.0	COG2825@1|root,COG2825@2|Bacteria,3J1AH@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
LZS2_k127_4998287_14	330214.NIDE3041	2.068e-68	235.0	COG0764@1|root,COG0764@2|Bacteria,3J0NG@40117|Nitrospirae	40117|Nitrospirae	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
LZS2_k127_4998287_6	330214.NIDE3040	5.085e-126	407.0	COG1043@1|root,COG1043@2|Bacteria,3J0G6@40117|Nitrospirae	40117|Nitrospirae	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
LZS2_k127_4998287_7	330214.NIDE3039	1.14e-125	407.0	COG3494@1|root,COG3494@2|Bacteria,3J0KP@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
LZS2_k127_4998287_9	330214.NIDE3038	3.96e-117	384.0	COG0673@1|root,COG0673@2|Bacteria,3J0M7@40117|Nitrospirae	40117|Nitrospirae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
LZS2_k127_4998287_11	269799.Gmet_2350	3.591e-79	277.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,43SZS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
LZS2_k127_4998287_1	330214.NIDE3036	5.833e-257	804.0	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS2_k127_4998287_15	330214.NIDE3035	3.917e-60	215.0	COG2121@1|root,COG2121@2|Bacteria,3J1AI@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
LZS2_k127_4998287_3	330214.NIDE3033	1.75e-155	502.0	COG1519@1|root,COG1519@2|Bacteria,3J0J7@40117|Nitrospirae	40117|Nitrospirae	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
LZS2_k127_4998287_17	404380.Gbem_0848	7.733e-55	209.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria,43SX0@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
LZS2_k127_4998287_2	330214.NIDE3031	2.069e-203	648.0	COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,3J0PZ@40117|Nitrospirae	40117|Nitrospirae	EM	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9,Hydrolase_like
LZS2_k127_4998287_8	857087.Metme_0403	5.703e-121	396.0	COG2227@1|root,COG2227@2|Bacteria,1NHGM@1224|Proteobacteria,1SHCF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_14,Methyltransf_23
LZS2_k127_4998287_10	330214.NIDE3030	1.08e-107	361.0	COG0859@1|root,COG0859@2|Bacteria,3J0KI@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
LZS2_k127_4998287_22	1191523.MROS_0886	3.837e-34	145.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
LZS2_k127_4998287_23	96561.Dole_1283	9.294e-34	139.0	COG1846@1|root,COG1846@2|Bacteria,1QUMZ@1224|Proteobacteria,42T2Y@68525|delta/epsilon subdivisions,2WPRZ@28221|Deltaproteobacteria,2MK9Z@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,Methyltransf_14
LZS2_k127_4998287_20	330214.NIDE2714	1.64e-44	167.0	COG0250@1|root,COG0250@2|Bacteria,3J17S@40117|Nitrospirae	40117|Nitrospirae	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
LZS2_k127_4998287_5	1265313.HRUBRA_01571	4.946e-146	475.0	COG2244@1|root,COG2244@2|Bacteria,1MUN5@1224|Proteobacteria,1RRAJ@1236|Gammaproteobacteria,1J9MM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Polysaccharide biosynthesis protein	wzx	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
LZS2_k127_4998287_13	118163.Ple7327_4376	6.471e-72	251.0	COG0438@1|root,COG0438@2|Bacteria,1G830@1117|Cyanobacteria,3VKAZ@52604|Pleurocapsales	1117|Cyanobacteria	M	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
LZS2_k127_4998287_12	1173263.Syn7502_03249	2.35e-75	263.0	COG1216@1|root,COG1216@2|Bacteria,1G2TX@1117|Cyanobacteria,1H0NU@1129|Synechococcus	1117|Cyanobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_4998287_18	216596.RL0815	1.699e-47	177.0	COG0110@1|root,COG0110@2|Bacteria,1N6SQ@1224|Proteobacteria,2V8CY@28211|Alphaproteobacteria,4BJZ2@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
LZS2_k127_4998287_24	1116472.MGMO_4c00090	2.55e-08	57.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,1RP4K@1236|Gammaproteobacteria,1XGMF@135618|Methylococcales	135618|Methylococcales	H	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
LZS2_k127_5021513_0	330214.NIDE0268	1.564e-111	369.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
LZS2_k127_5021513_1	330214.NIDE0277	1.311e-54	194.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
LZS2_k127_5038178_1	330214.NIDE1759	1.689e-129	419.0	COG0778@1|root,COG0778@2|Bacteria,3J0XZ@40117|Nitrospirae	40117|Nitrospirae	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038178_15	243159.AFE_0072	1.822e-15	79.0	2DP6Q@1|root,330SE@2|Bacteria,1NGB0@1224|Proteobacteria,1SGMT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038178_12	472759.Nhal_2304	2.771e-30	121.0	2E46S@1|root,32Z2Q@2|Bacteria,1N7X1@1224|Proteobacteria,1SEK8@1236|Gammaproteobacteria,1WZB0@135613|Chromatiales	135613|Chromatiales	S	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038178_3	330214.NIDE1751	9.566e-96	320.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE1751|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038178_16	269799.Gmet_1704	1.519e-14	81.0	COG3637@1|root,COG3637@2|Bacteria,1NHDI@1224|Proteobacteria,42X8Q@68525|delta/epsilon subdivisions,2WTDT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
LZS2_k127_5038178_7	330214.NIDE1750	5.686e-49	177.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE1750|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038178_2	330214.NIDE1748	2.892e-116	385.0	COG1819@1|root,COG1819@2|Bacteria	2|Bacteria	CG	transferase activity, transferring hexosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C
LZS2_k127_5038178_22	1123252.ATZF01000017_gene1790	0.0009701	50.0	COG2227@1|root,COG2227@2|Bacteria,1UHU9@1239|Firmicutes,4HFRY@91061|Bacilli,27B6P@186824|Thermoactinomycetaceae	91061|Bacilli	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
LZS2_k127_5038178_18	177437.HRM2_25500	3.922e-08	61.0	2AGE3@1|root,316JX@2|Bacteria,1NHX8@1224|Proteobacteria,42X67@68525|delta/epsilon subdivisions,2WT7A@28221|Deltaproteobacteria,2MM7G@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
LZS2_k127_5038178_8	335543.Sfum_2372	6.12e-48	183.0	COG0535@1|root,COG0535@2|Bacteria,1MYFX@1224|Proteobacteria,42SB0@68525|delta/epsilon subdivisions,2WPF4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS2_k127_5038178_10	335543.Sfum_2372	5.55e-45	177.0	COG0535@1|root,COG0535@2|Bacteria,1MYFX@1224|Proteobacteria,42SB0@68525|delta/epsilon subdivisions,2WPF4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS2_k127_5038178_17	694427.Palpr_1117	1.921e-11	76.0	28RJ8@1|root,32TGW@2|Bacteria,4P018@976|Bacteroidetes,2G095@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038178_11	335543.Sfum_2372	1.159e-36	153.0	COG0535@1|root,COG0535@2|Bacteria,1MYFX@1224|Proteobacteria,42SB0@68525|delta/epsilon subdivisions,2WPF4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS2_k127_5038178_19	1156937.MFUM_710012	6.961e-07	61.0	COG1216@1|root,COG1216@2|Bacteria,46X3K@74201|Verrucomicrobia,37H80@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
LZS2_k127_5038178_21	529709.PYCH_12280	4.975e-05	54.0	COG0681@1|root,arCOG01740@2157|Archaea,2XTAK@28890|Euryarchaeota,242WM@183968|Thermococci	183968|Thermococci	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
LZS2_k127_5038178_6	330214.NIDE1747	1.497e-51	189.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
LZS2_k127_5038178_9	330214.NIDE1746	3.788e-45	172.0	COG4372@1|root,COG5343@1|root,COG4372@2|Bacteria,COG5343@2|Bacteria	2|Bacteria	S	Anti-sigma-K factor rskA	-	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	LZ_Tnp_IS66,RskA,zf-HC2
LZS2_k127_5038178_4	330214.NIDE1745	3.656e-54	195.0	COG0590@1|root,COG0590@2|Bacteria,3J0PE@40117|Nitrospirae	40117|Nitrospirae	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
LZS2_k127_5038178_20	323848.Nmul_A0940	3.55e-05	51.0	COG0531@1|root,COG0531@2|Bacteria,1MX13@1224|Proteobacteria,2WFHQ@28216|Betaproteobacteria,371XS@32003|Nitrosomonadales	28216|Betaproteobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
LZS2_k127_5038178_0	671143.DAMO_1565	5.523e-257	805.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
LZS2_k127_5038178_13	261292.Nit79A3_1233	1.298e-29	119.0	arCOG08699@1|root,30TCX@2|Bacteria,1RDPE@1224|Proteobacteria,2WAZQ@28216|Betaproteobacteria,371U8@32003|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	AmoC
LZS2_k127_5038627_2	330214.NIDE4287	1.391e-52	187.0	COG0205@1|root,COG0406@1|root,COG0205@2|Bacteria,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	His_Phos_1,PFK
LZS2_k127_5038627_4	717773.Thicy_1492	2.618e-17	90.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,461CZ@72273|Thiotrichales	72273|Thiotrichales	S	COGs COG0790 FOG TPR repeat SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
LZS2_k127_5038627_0	1232410.KI421413_gene828	1.384e-94	317.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions,2WMYM@28221|Deltaproteobacteria,43SX2@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Bac_DnaA_C,Y1_Tnp
LZS2_k127_5038627_3	330214.NIDE2564	2.632e-28	114.0	2EI4B@1|root,33BVP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5038627_1	330214.NIDE3612	1.501e-53	190.0	2C8FN@1|root,2ZBER@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5044191_10	330214.NIDE3327	5.489e-43	159.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
LZS2_k127_5044191_9	330214.NIDE3334	1.429e-94	314.0	COG3751@1|root,COG3751@2|Bacteria	2|Bacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	ko:K07394	-	-	-	-	ko00000	-	-	-	2OG-FeII_Oxy_3,2OG-FeII_Oxy_4
LZS2_k127_5044191_11	330214.NIDE1261	3.133e-32	136.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
LZS2_k127_5044191_2	330214.NIDE3324	7.145e-214	674.0	COG1538@1|root,COG1538@2|Bacteria,3J0N2@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
LZS2_k127_5044191_6	330214.NIDE3323	4.016e-138	446.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
LZS2_k127_5044191_8	330214.NIDE3322	2.778e-113	371.0	COG1136@1|root,COG1136@2|Bacteria,3J10N@40117|Nitrospirae	2|Bacteria	V	Evidence 2b Function of strongly homologous gene	hrtA	-	-	ko:K02003,ko:K09810,ko:K09814	ko02010,map02010	M00255,M00257,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
LZS2_k127_5044191_3	330214.NIDE3321	2.608e-206	646.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS2_k127_5044191_5	330214.NIDE3318	7.561e-148	482.0	COG1293@1|root,COG1293@2|Bacteria	2|Bacteria	K	actin binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
LZS2_k127_5044191_0	69279.BG36_13100	5.352e-274	860.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,43I8J@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
LZS2_k127_5044191_12	886379.AEWI01000013_gene2105	1.502e-21	99.0	COG2337@1|root,COG2337@2|Bacteria,4NRIX@976|Bacteroidetes	976|Bacteroidetes	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
LZS2_k127_5044191_7	330214.NIDE3315	3.156e-123	409.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Cu_amine_oxidN1,F5_F8_type_C,IgGFc_binding,PKD
LZS2_k127_5044191_1	330214.NIDE3314	2.294e-268	839.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
LZS2_k127_5058988_4	697282.Mettu_0036	7.491e-50	180.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,1S5YQ@1236|Gammaproteobacteria,1XGJ6@135618|Methylococcales	135618|Methylococcales	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
LZS2_k127_5058988_3	330214.NIDE0316	1.073e-61	219.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE0316|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5058988_1	330214.NIDE1599	1.973e-126	408.0	COG0623@1|root,COG0623@2|Bacteria,3J11E@40117|Nitrospirae	40117|Nitrospirae	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
LZS2_k127_5058988_2	330214.NIDE0319	6.56e-82	274.0	COG0494@1|root,COG0494@2|Bacteria,3J0TN@40117|Nitrospirae	40117|Nitrospirae	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
LZS2_k127_5058988_0	330214.NIDE0320	6.829e-136	441.0	COG0404@1|root,COG0404@2|Bacteria,3J11R@40117|Nitrospirae	40117|Nitrospirae	H	Aminomethyltransferase folate-binding domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
LZS2_k127_5069510_4	330214.NIDE0547	2.521e-72	249.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
LZS2_k127_5069510_5	330214.NIDE0544	6.886e-71	252.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
LZS2_k127_5069510_6	330214.NIDE0543	1.574e-55	216.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0543|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5069510_2	330214.NIDE3387	2.084e-141	463.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_5069510_3	330214.NIDE1156	3.712e-81	276.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ2	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
LZS2_k127_5069510_1	330214.NIDE1155	3.031e-212	665.0	COG0477@1|root,COG2814@2|Bacteria,3J171@40117|Nitrospirae	40117|Nitrospirae	EGP	Sugar (and other) transporter	-	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1
LZS2_k127_5069510_0	330214.NIDE1150	0.0	1053.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,3J0NX@40117|Nitrospirae	40117|Nitrospirae	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
LZS2_k127_5083564_2	2340.JV46_05250	9.736e-56	205.0	COG0596@1|root,COG0596@2|Bacteria,1REZX@1224|Proteobacteria,1SCPB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
LZS2_k127_5083564_3	330214.NIDE2793	7.538e-40	150.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
LZS2_k127_5083564_1	156889.Mmc1_1104	5.799e-91	308.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG3000 Sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
LZS2_k127_5083564_6	870187.Thini_4430	5.347e-14	77.0	COG5572@1|root,COG5572@2|Bacteria,1PZ3H@1224|Proteobacteria,1SG80@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
LZS2_k127_5083564_0	381666.H16_A1821	1.626e-99	331.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,1K0J2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF2063,DUF692
LZS2_k127_5083564_5	314345.SPV1_06229	9.335e-17	90.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria	1224|Proteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
LZS2_k127_5083564_4	391596.PBAL39_07730	4.096e-22	100.0	COG2041@1|root,COG2041@2|Bacteria,4NEIQ@976|Bacteroidetes,1IQJN@117747|Sphingobacteriia	976|Bacteroidetes	S	Mo-co oxidoreductase dimerisation domain	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
LZS2_k127_5093236_0	1162668.LFE_1152	1.241e-265	824.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
LZS2_k127_5093236_1	330214.NIDE4369	8.191e-33	131.0	COG3357@1|root,COG3357@2|Bacteria	2|Bacteria	K	Transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	HTH_5,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
LZS2_k127_515435_2	330214.NIDE0226	3.176e-289	892.0	COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae	2|Bacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	ndhD	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhD2	Oxidored_q5_N,Proton_antipo_M
LZS2_k127_515435_4	330214.NIDE0227	7.702e-259	805.0	COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae	2|Bacteria	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_515435_1	330214.NIDE0228	0.0	1028.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341,ko:K05568,ko:K12139	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
LZS2_k127_515435_9	330214.NIDE0229	1.854e-45	166.0	COG0713@1|root,COG0713@2|Bacteria,3J1AK@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
LZS2_k127_515435_8	330214.NIDE0230	7.904e-72	246.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
LZS2_k127_515435_5	330214.NIDE0231	1.966e-107	349.0	COG1143@1|root,COG1143@2|Bacteria,3J0N0@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
LZS2_k127_515435_0	330214.NIDE0232	0.0	1419.0	COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	2|Bacteria	C	Molydopterin dinucleotide binding domain	hcnA	-	1.4.99.5,1.5.3.1	ko:K00302,ko:K10814	ko00260,ko00460,ko01100,ko01110,map00260,map00460,map01100,map01110	-	R00374,R00610,R05704	RC00060,RC00557,RC02808	ko00000,ko00001,ko01000,ko02042	-	-	-	Fer2_4
LZS2_k127_515435_3	330214.NIDE0233	1.874e-263	812.0	COG0649@1|root,COG0649@2|Bacteria,3J0FM@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
LZS2_k127_515435_7	330214.NIDE0234	5.263e-85	283.0	COG0852@1|root,COG0852@2|Bacteria,3J168@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
LZS2_k127_515435_6	330214.NIDE0235	2.654e-91	301.0	COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
LZS2_k127_5156517_3	330214.NIDE3224	9.61e-51	182.0	COG3071@1|root,COG3071@2|Bacteria	2|Bacteria	H	HemY protein	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_2
LZS2_k127_5156517_1	330214.NIDE3222	6.153e-161	511.0	COG0123@1|root,COG0123@2|Bacteria,3J0P2@40117|Nitrospirae	40117|Nitrospirae	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
LZS2_k127_5156517_0	330214.NIDE3221	1.504e-219	686.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5156517_2	330214.NIDE3220	3.504e-72	246.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	rhdA	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
LZS2_k127_5167239_5	330214.NIDE3967	3.758e-42	160.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
LZS2_k127_5167239_1	330214.NIDE3915	2.321e-201	636.0	COG1538@1|root,COG1538@2|Bacteria,3J19C@40117|Nitrospirae	40117|Nitrospirae	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	OEP
LZS2_k127_5167239_4	330214.NIDE0031	2.322e-139	452.0	COG1566@1|root,COG1566@2|Bacteria,3J0TB@40117|Nitrospirae	40117|Nitrospirae	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
LZS2_k127_5167239_0	330214.NIDE0032	2.167e-279	872.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_5167239_2	330214.NIDE0033	1.095e-166	531.0	COG0842@1|root,COG0842@2|Bacteria,3J0MP@40117|Nitrospirae	40117|Nitrospirae	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
LZS2_k127_5167239_3	330214.NIDE0034	5.561e-155	498.0	COG0842@1|root,COG0842@2|Bacteria,3J115@40117|Nitrospirae	40117|Nitrospirae	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
LZS2_k127_5167239_6	1122132.AQYH01000016_gene2904	0.0001623	49.0	2ETWY@1|root,33ME5@2|Bacteria,1N72E@1224|Proteobacteria,2UIFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5231454_7	123214.PERMA_1443	2.302e-37	150.0	COG3338@1|root,COG3338@2|Bacteria,2G4GS@200783|Aquificae	200783|Aquificae	P	Eukaryotic-type carbonic anhydrase	-	-	4.2.1.1	ko:K01674	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Carb_anhydrase
LZS2_k127_5231454_4	1121360.AUAQ01000012_gene1765	4.23e-75	263.0	COG4875@1|root,COG4875@2|Bacteria,2IGK4@201174|Actinobacteria,22Q17@1653|Corynebacteriaceae	201174|Actinobacteria	S	Calcium/calmodulin dependent protein kinase II association domain	-	-	-	-	-	-	-	-	-	-	-	-	CaMKII_AD,DUF4440
LZS2_k127_5231454_6	686340.Metal_2217	1.206e-47	184.0	2FARP@1|root,342Z3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5231454_5	330214.NIDE4390	3.004e-53	189.0	COG0347@1|root,COG0347@2|Bacteria,3J17N@40117|Nitrospirae	40117|Nitrospirae	K	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5231454_0	330214.NIDE4388	0.0	1436.0	COG3002@1|root,COG3002@2|Bacteria,3J0VY@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
LZS2_k127_5231454_3	330214.NIDE4387	3.564e-88	306.0	COG1008@1|root,COG1008@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_5231454_1	330214.NIDE4386	8.066e-232	730.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341,ko:K05577	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
LZS2_k127_5231454_2	330214.NIDE4386	1.046e-218	693.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	40117|Nitrospirae	CP	NADH-quinone oxidoreductase	-	-	1.6.5.3	ko:K00341,ko:K05577	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
LZS2_k127_5244144_4	330214.NIDE1834	1.162e-89	307.0	COG3547@1|root,COG3547@2|Bacteria,3J17W@40117|Nitrospirae	40117|Nitrospirae	L	hmm pf02371	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
LZS2_k127_5244144_8	46234.ANA_C10194	1.238e-32	141.0	COG0520@1|root,COG0520@2|Bacteria,1G2M5@1117|Cyanobacteria,1HJDF@1161|Nostocales	1117|Cyanobacteria	E	PFAM Aminotransferase class-V	cefD	-	5.1.1.17	ko:K04127,ko:K11325	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
LZS2_k127_5244144_7	1120951.AUBG01000006_gene358	5.034e-34	133.0	COG2343@1|root,COG2343@2|Bacteria,4NSIC@976|Bacteroidetes,1I3X7@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
LZS2_k127_5244144_0	1267535.KB906767_gene1504	2.211e-130	432.0	COG1262@1|root,COG1262@2|Bacteria,3Y3U7@57723|Acidobacteria	57723|Acidobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
LZS2_k127_5244144_1	1218084.BBJK01000002_gene158	2.017e-109	367.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,1K52I@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Methyltransferase	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
LZS2_k127_5244144_3	234267.Acid_1203	8.889e-94	320.0	COG1732@1|root,COG1732@2|Bacteria,3Y3Z9@57723|Acidobacteria	57723|Acidobacteria	M	ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
LZS2_k127_5244144_6	56107.Cylst_2489	7.781e-66	233.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria,1HJFJ@1161|Nostocales	1117|Cyanobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
LZS2_k127_5244144_2	497965.Cyan7822_5512	7.683e-94	314.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,3KHZZ@43988|Cyanothece	1117|Cyanobacteria	P	PFAM ABC transporter related	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
LZS2_k127_5244144_9	861299.J421_2935	0.0005817	44.0	COG0664@1|root,COG0664@2|Bacteria,1ZTHA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
LZS2_k127_5244144_5	1469607.KK073768_gene1940	1.464e-71	252.0	2CA71@1|root,2ZFTQ@2|Bacteria,1G57X@1117|Cyanobacteria,1HRH9@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5286221_1	330214.NIDE0238	6.036e-107	366.0	COG1198@1|root,COG1198@2|Bacteria,3J0MZ@40117|Nitrospirae	40117|Nitrospirae	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
LZS2_k127_5286221_8	330214.NIDE0240	1.218e-12	74.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE0240|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5286221_3	1173028.ANKO01000074_gene3009	5.743e-61	237.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_5286221_4	1237500.ANBA01000008_gene363	3.081e-55	202.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4EIAM@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
LZS2_k127_5286221_0	395961.Cyan7425_2336	5.666e-117	428.0	COG2202@1|root,COG3290@1|root,COG3920@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,3KKV1@43988|Cyanothece	1117|Cyanobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9
LZS2_k127_5286221_5	1121918.ARWE01000001_gene3199	1.932e-49	201.0	COG2199@1|root,COG2202@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_5286221_2	330214.NIDE0243	1.321e-86	292.0	COG0560@1|root,COG0560@2|Bacteria	2|Bacteria	E	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4,Sterile
LZS2_k127_5286221_7	330214.NIDE0244	4.027e-20	90.0	COG0602@1|root,COG0602@2|Bacteria,3J0M2@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
LZS2_k127_5303821_6	330214.NIDE4100	2.297e-22	99.0	COG4940@1|root,COG4940@2|Bacteria	2|Bacteria	U	Putative Competence protein ComGF	comGF	-	-	ko:K02246,ko:K02248	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComGF,N_methyl
LZS2_k127_5303821_3	330214.NIDE4099	4.042e-31	133.0	COG4966@1|root,COG4966@2|Bacteria	2|Bacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
LZS2_k127_5303821_1	330214.NIDE4098	8.755e-106	361.0	COG3217@1|root,COG4726@1|root,COG3217@2|Bacteria,COG4726@2|Bacteria	2|Bacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	DUF3494,MOSC_N
LZS2_k127_5303821_0	330214.NIDE4097	4.109e-244	767.0	COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
LZS2_k127_5303821_8	330214.NIDE4096	3.119e-11	71.0	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	GspH,N_methyl
LZS2_k127_5303821_5	330214.NIDE4095	2.351e-24	109.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	ppdC	-	-	ko:K02671,ko:K02681,ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	N_methyl,T2SSppdC
LZS2_k127_5303821_2	330214.NIDE4094	3.955e-54	206.0	COG4966@1|root,COG4966@2|Bacteria	2|Bacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
LZS2_k127_534508_0	330214.NIDE1559	2.691e-106	357.0	COG4395@1|root,COG4395@2|Bacteria	2|Bacteria	S	Tim44	MA20_08550	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	Tim44
LZS2_k127_534508_1	227086.JGI_V11_33711	2.807e-67	236.0	2BBKE@1|root,2S0Y6@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_534508_2	330214.NIDE2564	7.258e-28	112.0	2EI4B@1|root,33BVP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5346231_0	472759.Nhal_2124	7.507e-81	277.0	COG1215@1|root,COG1215@2|Bacteria,1QU2M@1224|Proteobacteria,1SCHV@1236|Gammaproteobacteria,1X2RE@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS2_k127_5346231_1	247490.KSU1_C0096	2.138e-47	181.0	COG0398@1|root,COG0398@2|Bacteria,2J4Y1@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function, DUF547	-	-	-	-	-	-	-	-	-	-	-	-	DUF547
LZS2_k127_5346231_2	1121335.Clst_0122	2.382e-38	156.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
LZS2_k127_5349789_1	1279009.ADICEAN_01483	1.969e-75	273.0	COG0668@1|root,COG0668@2|Bacteria,4NFC6@976|Bacteroidetes,47YNQ@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	mscM	-	-	-	-	-	-	-	-	-	-	-	MS_channel
LZS2_k127_5349789_0	1267535.KB906767_gene1954	1.841e-95	324.0	2AG8X@1|root,316EB@2|Bacteria,3Y75Y@57723|Acidobacteria,2JNUP@204432|Acidobacteriia	204432|Acidobacteriia	S	Plasmid encoded RepA protein	-	-	-	-	-	-	-	-	-	-	-	-	RepA_C
LZS2_k127_5362717_0	330214.NIDE1819	9.012e-251	776.0	COG0498@1|root,COG0498@2|Bacteria,3J0FZ@40117|Nitrospirae	40117|Nitrospirae	E	Pyridoxal-phosphate dependent enzyme	thrC1	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
LZS2_k127_5362717_4	330214.NIDE1818	6.501e-42	154.0	COG1977@1|root,COG1977@2|Bacteria,3J0T2@40117|Nitrospirae	40117|Nitrospirae	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS2_k127_5362717_5	330214.NIDE1817	1.874e-35	136.0	COG1135@1|root,COG1135@2|Bacteria,3J0VT@40117|Nitrospirae	40117|Nitrospirae	P	NIL	-	-	-	-	-	-	-	-	-	-	-	-	NIL
LZS2_k127_5362717_2	330214.NIDE1816	1.891e-144	461.0	COG0476@1|root,COG0476@2|Bacteria,3J0X5@40117|Nitrospirae	40117|Nitrospirae	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
LZS2_k127_5362717_3	330214.NIDE1815	3.544e-74	254.0	COG1310@1|root,COG1310@2|Bacteria,3J0U8@40117|Nitrospirae	40117|Nitrospirae	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
LZS2_k127_5362717_1	330214.NIDE1807	4.259e-154	491.0	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS2_k127_5375946_2	330214.NIDE4254	8.994e-152	484.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
LZS2_k127_5375946_3	330214.NIDE3500	2.805e-67	234.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
LZS2_k127_5375946_0	330214.NIDE3501	2.9e-208	666.0	COG4907@1|root,COG4907@2|Bacteria	2|Bacteria	P	membrane protein (DUF2207)	yciQ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2207
LZS2_k127_5375946_5	330214.NIDE4258	6.979e-46	175.0	2E4EY@1|root,32ZA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5575110_0	697282.Mettu_0517	2.107e-234	736.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,1T9X2@1236|Gammaproteobacteria,1XG04@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5596424_5	748658.KB907314_gene100	0.0005313	51.0	2DBXQ@1|root,2ZBQY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
LZS2_k127_5596424_1	330214.NIDE3395	8.41e-25	107.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS2_k127_5596424_0	583355.Caka_0712	3.083e-139	456.0	COG0617@1|root,COG0617@2|Bacteria,46UER@74201|Verrucomicrobia,3K732@414999|Opitutae	414999|Opitutae	J	Polynucleotide adenylyltransferase	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
LZS2_k127_5596424_2	330214.NIDE3393	7.661e-22	94.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
LZS2_k127_5602568_16	588596.U9SJG8	3.452e-05	55.0	COG0790@1|root,KOG1550@2759|Eukaryota,39WUS@33154|Opisthokonta,3P062@4751|Fungi	588596.U9SJG8|-	MOT	Sel1-like repeats.	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5602568_9	5011.R4X6K8	1.028e-46	177.0	COG0543@1|root,KOG0534@2759|Eukaryota,38GQ8@33154|Opisthokonta,3NW9T@4751|Fungi,3QJTV@4890|Ascomycota,3MBXH@451866|Taphrinomycotina	4751|Fungi	C	belongs to the flavoprotein pyridine nucleotide cytochrome reductase family	CBR1	GO:0000166,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004128,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0005886,GO:0006091,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016070,GO:0016491,GO:0016651,GO:0016653,GO:0019867,GO:0022900,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0098588,GO:0098805,GO:1901265,GO:1901360,GO:1901363	1.6.2.2	ko:K00326	ko00520,map00520	-	R00100	-	ko00000,ko00001,ko01000	-	-	iMM904.YIL043C	FAD_binding_6,NAD_binding_1
LZS2_k127_5602568_0	330214.NIDE1217	1.379e-206	655.0	COG1232@1|root,COG1232@2|Bacteria,3J0PQ@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
LZS2_k127_5602568_3	330214.NIDE1216	2.442e-138	447.0	COG0276@1|root,COG0276@2|Bacteria,3J0P9@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
LZS2_k127_5602568_1	330214.NIDE1215	1.324e-193	606.0	COG0407@1|root,COG0407@2|Bacteria,3J0C3@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
LZS2_k127_5602568_2	330214.NIDE1213	2.771e-167	531.0	COG1398@1|root,COG1398@2|Bacteria	2|Bacteria	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
LZS2_k127_5602568_5	330214.NIDE1211	3.143e-99	331.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yedA	-	-	-	-	-	-	-	-	-	-	-	EamA
LZS2_k127_5602568_13	330214.NIDE1208	2.996e-22	99.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
LZS2_k127_5602568_6	330214.NIDE1207	9.613e-91	306.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
LZS2_k127_5602568_4	330214.NIDE2211	1.258e-126	410.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	rmlA	GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.7.13,2.7.7.24,2.7.7.99	ko:K00966,ko:K00973,ko:K00992	ko00051,ko00520,ko00521,ko00523,ko00525,ko01100,ko01110,ko01130,map00051,map00520,map00521,map00523,map00525,map01100,map01110,map01130	M00114,M00361,M00362,M00793	R00885,R02328,R11025	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
LZS2_k127_5606626_1	204669.Acid345_1704	8.746e-32	127.0	COG0309@1|root,COG0309@2|Bacteria,3Y3UH@57723|Acidobacteria,2JK96@204432|Acidobacteriia	204432|Acidobacteriia	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
LZS2_k127_5606626_0	518766.Rmar_2595	2.206e-163	521.0	COG0409@1|root,COG0409@2|Bacteria,4NIM8@976|Bacteroidetes	976|Bacteroidetes	O	TIGRFAM hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
LZS2_k127_5606626_5	1282360.ABAC460_08205	2.546e-13	72.0	COG4118@1|root,COG4118@2|Bacteria,1NME9@1224|Proteobacteria,2UMMS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
LZS2_k127_5606626_2	324602.Caur_2253	2.161e-30	124.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS2_k127_5606626_3	340177.Cag_0530	2.783e-18	86.0	COG0409@1|root,COG0409@2|Bacteria,1FD8B@1090|Chlorobi	1090|Chlorobi	O	hydrogenase expression formation protein HypD	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
LZS2_k127_5606626_4	398512.JQKC01000007_gene1071	5.027e-15	85.0	COG0457@1|root,COG0457@2|Bacteria	398512.JQKC01000007_gene1071|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5617295_24	330214.NIDE3363	3.698e-15	77.0	COG0811@1|root,COG0811@2|Bacteria,3J0PX@40117|Nitrospirae	40117|Nitrospirae	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
LZS2_k127_5617295_20	330214.NIDE3362	7.79e-64	221.0	COG0848@1|root,COG0848@2|Bacteria,3J0T6@40117|Nitrospirae	40117|Nitrospirae	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
LZS2_k127_5617295_21	330214.NIDE3361	1.505e-61	226.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	ko:K03646,ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1,2.C.1.2	-	-	CarbopepD_reg_2,TonB_2,TonB_C
LZS2_k127_5617295_2	330214.NIDE3360	4.008e-218	683.0	COG0823@1|root,COG0823@2|Bacteria,3J0U9@40117|Nitrospirae	40117|Nitrospirae	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
LZS2_k127_5617295_19	330214.NIDE3359	3.348e-66	236.0	COG2885@1|root,COG2885@2|Bacteria,3J17Q@40117|Nitrospirae	2|Bacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
LZS2_k127_5617295_14	330214.NIDE3358	9.168e-95	327.0	COG1729@1|root,COG4372@1|root,COG1729@2|Bacteria,COG4372@2|Bacteria	2|Bacteria	Q	Transposase	-	-	-	ko:K01991,ko:K02557,ko:K07161,ko:K07484	ko02026,ko02030,ko02040,map02026,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.18	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,DUF3084,LZ_Tnp_IS66,TPR_6,zf-IS66
LZS2_k127_5617295_16	330214.NIDE3357	6.097e-80	274.0	COG1729@1|root,COG1729@2|Bacteria,3J0RE@40117|Nitrospirae	40117|Nitrospirae	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
LZS2_k127_5617295_3	330214.NIDE3356	4.527e-204	653.0	COG0323@1|root,COG0323@2|Bacteria,3J0GN@40117|Nitrospirae	40117|Nitrospirae	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
LZS2_k127_5617295_11	330214.NIDE3355	6.903e-113	374.0	COG0324@1|root,COG0324@2|Bacteria,3J0KS@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
LZS2_k127_5617295_7	330214.NIDE3354	2.298e-136	441.0	COG0005@1|root,COG0005@2|Bacteria,3J0HC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
LZS2_k127_5617295_5	330214.NIDE3353	1.281e-174	550.0	COG0524@1|root,COG0524@2|Bacteria,3J0ZT@40117|Nitrospirae	40117|Nitrospirae	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
LZS2_k127_5617295_15	330214.NIDE3352	9.397e-85	287.0	COG3063@1|root,COG3063@2|Bacteria,3J0V4@40117|Nitrospirae	40117|Nitrospirae	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
LZS2_k127_5617295_12	330214.NIDE3351	1.847e-112	370.0	COG1426@1|root,COG1426@2|Bacteria,3J1CJ@40117|Nitrospirae	40117|Nitrospirae	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
LZS2_k127_5617295_18	330214.NIDE3350	4.472e-71	242.0	COG2010@1|root,COG2010@2|Bacteria,3J17C@40117|Nitrospirae	2|Bacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
LZS2_k127_5617295_22	246197.MXAN_5800	6.377e-44	181.0	COG2931@1|root,COG5184@1|root,COG2931@2|Bacteria,COG5184@2|Bacteria,1QXVA@1224|Proteobacteria	1224|Proteobacteria	DZ	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,TIG
LZS2_k127_5617295_9	330214.NIDE3349	2.934e-126	426.0	COG4249@1|root,COG4249@2|Bacteria,3J0QX@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Peptidase_C14
LZS2_k127_5617295_1	330214.NIDE3344	1.321e-227	714.0	COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria,3J0VW@40117|Nitrospirae	40117|Nitrospirae	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
LZS2_k127_5617295_6	330214.NIDE3343	2.227e-141	454.0	COG0805@1|root,COG0805@2|Bacteria,3J0PJ@40117|Nitrospirae	40117|Nitrospirae	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
LZS2_k127_5617295_4	330214.NIDE3342	1.358e-192	603.0	COG0489@1|root,COG0489@2|Bacteria,3J10K@40117|Nitrospirae	40117|Nitrospirae	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
LZS2_k127_5617295_0	330214.NIDE3341	5.302e-229	714.0	COG0303@1|root,COG0303@2|Bacteria,3J0MX@40117|Nitrospirae	40117|Nitrospirae	H	Probable molybdopterin binding domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
LZS2_k127_5617295_17	330214.NIDE3340	5.351e-76	258.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.10.1.1,2.7.7.77	ko:K03750,ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R09735,R11581	RC03462	ko00000,ko00001,ko01000	-	-	iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	MoCF_biosynth,MobB,MoeA_C,MoeA_N
LZS2_k127_5617295_13	330214.NIDE3339	7.858e-106	347.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	ko:K02569,ko:K03532,ko:K15876	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko02000	5.A.3.4	-	-	Cytochrom_NNT,Cytochrome_C7
LZS2_k127_5617295_10	330214.NIDE3338	8.389e-115	374.0	COG1131@1|root,COG1131@2|Bacteria,3J116@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_5617295_8	330214.NIDE3335	3.563e-127	410.0	COG1682@1|root,COG1682@2|Bacteria	2|Bacteria	GM	macromolecule localization	-	-	-	ko:K01421,ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane,ABC2_membrane_3,DUF3533
LZS2_k127_5640618_2	1304883.KI912532_gene976	1.963e-10	70.0	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,2VKUS@28216|Betaproteobacteria,2KVZ9@206389|Rhodocyclales	206389|Rhodocyclales	M	TonB C terminal	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
LZS2_k127_5640618_1	388401.RB2150_00085	2.537e-15	82.0	2EVF3@1|root,33NVI@2|Bacteria,1NPYI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
LZS2_k127_5640618_3	879212.DespoDRAFT_03569	1.946e-08	62.0	COG3409@1|root,COG3409@2|Bacteria,1NGZT@1224|Proteobacteria	1224|Proteobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
LZS2_k127_5645265_1	330214.NIDE3311	9.14e-160	507.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
LZS2_k127_5645265_5	330214.NIDE3309	1.321e-103	352.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
LZS2_k127_5645265_3	330214.NIDE4175	6.592e-136	437.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_5645265_0	330214.NIDE4178	4.544e-168	531.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_5645265_6	330214.NIDE4179	1.461e-81	278.0	COG3026@1|root,COG3026@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	DUF4412,FtsX,LolA_like,MucB_RseB,MucB_RseB_C,zf-HC2
LZS2_k127_5645265_4	330214.NIDE3373	2.698e-128	417.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase,NACHT
LZS2_k127_5645265_2	330214.NIDE1429	1.503e-145	468.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
LZS2_k127_5645265_8	1122223.KB890700_gene1975	5.764e-18	85.0	COG0009@1|root,COG0009@2|Bacteria,1WJN4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
LZS2_k127_5653932_20	330214.NIDE3074	6.844e-13	68.0	COG0541@1|root,COG0541@2|Bacteria,3J0DT@40117|Nitrospirae	40117|Nitrospirae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
LZS2_k127_5653932_17	330214.NIDE3073	8.391e-41	153.0	COG0228@1|root,COG0228@2|Bacteria,3J0UI@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
LZS2_k127_5653932_16	330214.NIDE3072	2.51e-51	186.0	COG0806@1|root,COG0806@2|Bacteria	2|Bacteria	J	ribosome binding	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
LZS2_k127_5653932_8	330214.NIDE3071	8.357e-109	357.0	COG0336@1|root,COG0336@2|Bacteria,3J0JN@40117|Nitrospirae	40117|Nitrospirae	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
LZS2_k127_5653932_13	330214.NIDE3070	1.049e-55	198.0	COG0335@1|root,COG0335@2|Bacteria,3J0MJ@40117|Nitrospirae	40117|Nitrospirae	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
LZS2_k127_5653932_11	330214.NIDE3069	5.784e-79	270.0	COG0164@1|root,COG0164@2|Bacteria,3J0P5@40117|Nitrospirae	40117|Nitrospirae	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
LZS2_k127_5653932_18	330214.NIDE3068	3.941e-33	132.0	COG0792@1|root,COG0792@2|Bacteria,3J1ER@40117|Nitrospirae	40117|Nitrospirae	L	Uncharacterised protein family UPF0102	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
LZS2_k127_5653932_10	330214.NIDE3067	7.137e-99	327.0	COG2884@1|root,COG2884@2|Bacteria,3J139@40117|Nitrospirae	40117|Nitrospirae	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
LZS2_k127_5653932_7	330214.NIDE3066	5.99e-109	362.0	COG2177@1|root,COG2177@2|Bacteria,3J18Q@40117|Nitrospirae	40117|Nitrospirae	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
LZS2_k127_5653932_5	330214.NIDE3065	1.359e-135	444.0	COG4942@1|root,COG4942@2|Bacteria,3J0SP@40117|Nitrospirae	40117|Nitrospirae	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
LZS2_k127_5653932_3	330214.NIDE3064	1.75e-208	656.0	COG0793@1|root,COG0793@2|Bacteria,3J09Y@40117|Nitrospirae	40117|Nitrospirae	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,Peptidase_S41
LZS2_k127_5653932_14	330214.NIDE3063	1.714e-53	192.0	COG1796@1|root,COG1796@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dpbF	-	3.1.11.5	ko:K02347,ko:K03581,ko:K04477	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,HHH_8
LZS2_k127_5653932_19	330214.NIDE3061	1.995e-18	86.0	COG2104@1|root,COG2104@2|Bacteria,3J1CM@40117|Nitrospirae	40117|Nitrospirae	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS2_k127_5653932_4	330214.NIDE3060	2.814e-147	468.0	COG2022@1|root,COG2022@2|Bacteria,3J0EI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
LZS2_k127_5653932_12	330214.NIDE3059	1.396e-57	207.0	COG0352@1|root,COG0352@2|Bacteria,3J0QS@40117|Nitrospirae	40117|Nitrospirae	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE2	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
LZS2_k127_5653932_0	330214.NIDE3058	0.0	1019.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
LZS2_k127_5653932_2	330214.NIDE3057	7.61e-240	752.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119,6.3.1.19	ko:K13571,ko:K20814	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
LZS2_k127_5653932_6	330214.NIDE3056	1.7e-124	404.0	COG0638@1|root,COG0638@2|Bacteria	2|Bacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
LZS2_k127_5653932_9	330214.NIDE3055	9.29e-102	338.0	COG0638@1|root,COG0638@2|Bacteria	2|Bacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
LZS2_k127_5653932_1	330214.NIDE3054	1.474e-277	856.0	COG0638@1|root,COG0638@2|Bacteria	2|Bacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
LZS2_k127_5653932_15	330214.NIDE3053	5.947e-53	197.0	COG0739@1|root,COG0739@2|Bacteria,3J16B@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
LZS2_k127_5690541_7	404589.Anae109_0837	7.062e-05	45.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2YUHQ@29|Myxococcales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
LZS2_k127_5690541_5	330214.NIDE3717	7.903e-49	176.0	COG0607@1|root,COG0607@2|Bacteria,3J17U@40117|Nitrospirae	40117|Nitrospirae	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
LZS2_k127_5690541_0	330214.NIDE3718	4.395e-147	470.0	COG0451@1|root,COG0451@2|Bacteria,3J12G@40117|Nitrospirae	40117|Nitrospirae	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
LZS2_k127_5690541_3	330214.NIDE3719	3.057e-85	293.0	COG1189@1|root,COG1189@2|Bacteria,3J0MD@40117|Nitrospirae	40117|Nitrospirae	J	FtsJ-like methyltransferase	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
LZS2_k127_5690541_6	330214.NIDE3720	8.038e-27	112.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
LZS2_k127_5690541_1	330214.NIDE3721	6.389e-140	459.0	COG1570@1|root,COG1570@2|Bacteria,3J0S9@40117|Nitrospirae	40117|Nitrospirae	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
LZS2_k127_5690541_2	330214.NIDE3722	4.672e-133	428.0	COG1692@1|root,COG1692@2|Bacteria,3J0JW@40117|Nitrospirae	40117|Nitrospirae	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
LZS2_k127_5690541_4	330214.NIDE3723	2.341e-66	227.0	COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,3J0C8@40117|Nitrospirae	40117|Nitrospirae	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
LZS2_k127_5697349_0	330214.NIDE3664	1.601e-115	379.0	COG0679@1|root,COG0679@2|Bacteria,3J1EB@40117|Nitrospirae	40117|Nitrospirae	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
LZS2_k127_5697349_1	330214.NIDE3787	6.981e-81	278.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	CBS,Ion_trans_2
LZS2_k127_5697349_2	396588.Tgr7_0142	1.001e-64	225.0	COG2110@1|root,COG2110@2|Bacteria,1MVYN@1224|Proteobacteria,1SBA6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Macro domain	-	-	-	-	-	-	-	-	-	-	-	-	Macro
LZS2_k127_5700290_1	330214.NIDE0342	1.784e-196	636.0	COG1305@1|root,COG1305@2|Bacteria,3J150@40117|Nitrospirae	40117|Nitrospirae	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,Transglut_core
LZS2_k127_5700290_2	935836.JAEL01000201_gene4586	1.408e-08	56.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5700290_0	330214.NIDE3255	0.0	1814.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	ddhA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.17.99.2,1.7.5.1,1.8.2.4	ko:K00370,ko:K10700,ko:K16964,ko:K17050	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
LZS2_k127_5709688_3	330214.NIDE4204	1.322e-82	289.0	COG3769@1|root,COG3769@2|Bacteria	2|Bacteria	S	mannosylglycerate metabolic process	mpgP	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897	2.4.1.217,3.1.3.70	ko:K05947,ko:K07026	ko00051,map00051	-	R05768,R05790	RC00005,RC00017,RC00397,RC02748	ko00000,ko00001,ko01000,ko01003	-	-	-	Hydrolase_3
LZS2_k127_5709688_4	330214.NIDE4206	8.683e-73	253.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
LZS2_k127_5709688_1	330214.NIDE1666	4.421e-214	670.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266	ko:K13693	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	-
LZS2_k127_5709688_0	330214.NIDE1669	1.461e-273	849.0	COG3961@1|root,COG3961@2|Bacteria	2|Bacteria	GH	pyruvate decarboxylase activity	ipdC	-	4.1.1.74	ko:K04103	ko00380,ko01100,map00380,map01100	-	R01974	RC00506	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
LZS2_k127_5709688_2	330214.NIDE1670	1.106e-143	466.0	COG1092@1|root,COG1092@2|Bacteria,3J0IV@40117|Nitrospirae	40117|Nitrospirae	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
LZS2_k127_5709688_5	994479.GL877878_gene265	3.009e-08	63.0	COG1403@1|root,COG1403@2|Bacteria,2GV0W@201174|Actinobacteria,4E79M@85010|Pseudonocardiales	201174|Actinobacteria	V	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,HNH,HNH_5,TerD
LZS2_k127_5709688_6	367336.OM2255_05020	0.0004082	44.0	2BBKE@1|root,33TKD@2|Bacteria,1NRG3@1224|Proteobacteria,2UPJY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5735113_5	1385935.N836_10705	3.473e-20	93.0	2ETWY@1|root,32VZU@2|Bacteria,1G9Y9@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5735113_3	330214.NIDE3911	2.855e-107	362.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
LZS2_k127_5735113_1	330214.NIDE3903	2.124e-289	897.0	COG0058@1|root,COG0058@2|Bacteria,3J0W1@40117|Nitrospirae	40117|Nitrospirae	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
LZS2_k127_5735113_2	330214.NIDE3516	2.951e-147	477.0	COG0282@1|root,COG0282@2|Bacteria,3J12N@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
LZS2_k127_5735113_0	1038860.AXAP01000015_gene2094	0.0	1391.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	aldehyde-lyase activity	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
LZS2_k127_5735113_4	330214.NIDE3910	1.306e-71	255.0	COG3170@1|root,COG3170@2|Bacteria,3J1CW@40117|Nitrospirae	40117|Nitrospirae	NU	Protein of unknown function (DUF1207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1207
LZS2_k127_5735113_6	1121861.KB899929_gene305	6.66e-10	63.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,2JW64@204441|Rhodospirillales	204441|Rhodospirillales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
LZS2_k127_5736240_7	1000565.METUNv1_00250	1.905e-48	183.0	COG2267@1|root,COG2267@2|Bacteria,1N0W6@1224|Proteobacteria,2VSJ4@28216|Betaproteobacteria,2KZD3@206389|Rhodocyclales	206389|Rhodocyclales	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5736240_5	1026882.MAMP_01480	1.876e-116	385.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,1RQIA@1236|Gammaproteobacteria,4605X@72273|Thiotrichales	72273|Thiotrichales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
LZS2_k127_5736240_0	296587.XP_002508168.1	1.596e-251	798.0	COG4992@1|root,KOG1401@2759|Eukaryota,37NS6@33090|Viridiplantae,34GPP@3041|Chlorophyta	2759|Eukaryota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
LZS2_k127_5736240_4	1026882.MAMP_01482	1.189e-125	411.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,45ZWE@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
LZS2_k127_5736240_6	1454004.AW11_03199	1.714e-53	195.0	COG5156@1|root,COG5156@2|Bacteria,1N53Q@1224|Proteobacteria,2W66Z@28216|Betaproteobacteria	28216|Betaproteobacteria	DO	anaphase-promoting complex-dependent catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5736240_8	886293.Sinac_1280	6.384e-30	121.0	COG1544@1|root,COG1544@2|Bacteria,2J0UN@203682|Planctomycetes	203682|Planctomycetes	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
LZS2_k127_5736240_1	1288494.EBAPG3_12190	1.79e-238	745.0	COG0531@1|root,COG0531@2|Bacteria,1MX13@1224|Proteobacteria,2WFHQ@28216|Betaproteobacteria,371XS@32003|Nitrosomonadales	28216|Betaproteobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
LZS2_k127_5736240_2	1123023.JIAI01000009_gene986	1.739e-212	663.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4E9T2@85010|Pseudonocardiales	201174|Actinobacteria	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
LZS2_k127_5736240_3	330214.NIDE0277	4.067e-176	567.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2,DUF748
LZS2_k127_5741971_4	330214.NIDE1525	5.259e-77	258.0	COG0432@1|root,COG0432@2|Bacteria,3J1CB@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
LZS2_k127_5741971_5	330214.NIDE1527	2.394e-16	87.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	ko:K18491	ko04550,map04550	-	-	-	ko00000,ko00001,ko03000	-	-	-	DUF4157
LZS2_k127_5741971_1	330214.NIDE1530	4.943e-120	401.0	COG0515@1|root,COG0515@2|Bacteria	330214.NIDE1530|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
LZS2_k127_5741971_2	330214.NIDE1531	7.331e-116	379.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	trpH	-	3.1.3.97,4.1.2.13	ko:K01624,ko:K07053	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R00188,R01068,R01070,R01829,R02568,R11188	RC00078,RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
LZS2_k127_5741971_3	330214.NIDE1532	1.006e-105	354.0	COG1539@1|root,COG2520@1|root,COG1539@2|Bacteria,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	folB	-	1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8	ko:K01091,ko:K01633,ko:K15429	ko00630,ko00790,ko01100,ko01110,ko01130,map00630,map00790,map01100,map01110,map01130	M00126,M00840	R00597,R01334,R03504,R11037,R11073	RC00003,RC00017,RC00334,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	FolB,rRNA_methylase
LZS2_k127_5741971_6	330214.NIDE2199	1.401e-05	47.0	COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD
LZS2_k127_5745456_2	330214.NIDE4392	8.472e-62	215.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS2_k127_5745456_0	330214.NIDE4395	3.733e-137	444.0	COG0457@1|root,COG0457@2|Bacteria,3J1CG@40117|Nitrospirae	330214.NIDE4395|-	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5745456_1	330214.NIDE4396	4.04e-122	394.0	COG1351@1|root,COG1351@2|Bacteria	2|Bacteria	F	thymidylate synthase (FAD) activity	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
LZS2_k127_5755472_2	243231.GSU1203	1.633e-34	134.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,42MWU@68525|delta/epsilon subdivisions,2WKCW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
LZS2_k127_5755472_1	330214.NIDE0017	3.801e-35	135.0	COG3369@1|root,COG3369@2|Bacteria,3J1A6@40117|Nitrospirae	40117|Nitrospirae	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
LZS2_k127_5755472_0	234267.Acid_7913	3.43e-160	520.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria,3Y9A3@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,GAF_3,HTH_8,Sigma54_activat
LZS2_k127_5767871_0	330214.NIDE2337	2.307e-149	480.0	COG0859@1|root,COG0859@2|Bacteria,3J197@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
LZS2_k127_5767871_1	330214.NIDE2336	1.548e-115	379.0	COG4641@1|root,COG4641@2|Bacteria,3J0ZZ@40117|Nitrospirae	40117|Nitrospirae	S	DUF based on E. rectale Gene description (DUF3880)	-	-	-	ko:K06320	-	-	-	-	ko00000	-	-	-	DUF3880,Glyco_trans_1_2
LZS2_k127_5783809_1	330214.NIDE0223	5.956e-41	152.0	COG0745@1|root,COG0745@2|Bacteria,3J151@40117|Nitrospirae	40117|Nitrospirae	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
LZS2_k127_5783809_0	330214.NIDE0224	1.275e-170	548.0	COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,3J12S@40117|Nitrospirae	40117|Nitrospirae	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA
LZS2_k127_5783809_2	330214.NIDE0225	1.179e-13	71.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_5789139_16	330214.NIDE2658	4.377e-13	74.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
LZS2_k127_5789139_12	330214.NIDE2658	6.99e-38	145.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
LZS2_k127_5789139_9	330214.NIDE2657	1.824e-57	203.0	COG0745@1|root,COG0745@2|Bacteria,3J16K@40117|Nitrospirae	40117|Nitrospirae	T	cheY-homologous receiver domain	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
LZS2_k127_5789139_13	330214.NIDE2656	1.427e-34	138.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW2	-	-	ko:K03408,ko:K03415	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheW
LZS2_k127_5789139_0	330214.NIDE2655	5.228e-216	688.0	COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,3J11V@40117|Nitrospirae	40117|Nitrospirae	T	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	HAMP,MCPsignal
LZS2_k127_5789139_3	1499967.BAYZ01000004_gene4927	2.648e-144	497.0	COG0643@1|root,COG0643@2|Bacteria,2NQEX@2323|unclassified Bacteria	2|Bacteria	T	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
LZS2_k127_5789139_14	330214.NIDE2652	1.687e-28	121.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW	-	-	ko:K02659,ko:K03408,ko:K03415,ko:K11524	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	CheW
LZS2_k127_5789139_7	330214.NIDE2651	2.074e-85	297.0	COG0784@1|root,COG1196@1|root,COG0784@2|Bacteria,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	asgA	-	-	ko:K02666,ko:K03497,ko:K19622	ko02020,map02020	-	-	-	ko00000,ko00001,ko02022,ko02035,ko02044,ko03000,ko03036,ko04812	3.A.15.2	-	-	HATPase_c,HATPase_c_2,HisKA,HisKA_2,HisKA_3,Response_reg
LZS2_k127_5789139_10	330214.NIDE2650	2.172e-47	182.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	cnpD3	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,HD_5
LZS2_k127_5789139_8	237368.SCABRO_01324	7.341e-66	235.0	COG3267@1|root,COG3267@2|Bacteria,2IZGI@203682|Planctomycetes	203682|Planctomycetes	U	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
LZS2_k127_5789139_6	330214.NIDE2649	1.953e-117	388.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD_5
LZS2_k127_5789139_4	330214.NIDE2646	1.757e-135	443.0	COG1044@1|root,COG1044@2|Bacteria,3J0GQ@40117|Nitrospirae	40117|Nitrospirae	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
LZS2_k127_5789139_15	330214.NIDE2645	1.546e-26	115.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078,ko:K05553	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516	RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947	ko00000,ko00001,ko00002,ko01004,ko01008	-	-	-	PP-binding
LZS2_k127_5789139_1	330214.NIDE2644	6.219e-198	624.0	COG0304@1|root,COG0304@2|Bacteria,3J0DH@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
LZS2_k127_5789139_5	330214.NIDE2643	6.358e-135	438.0	COG0795@1|root,COG0795@2|Bacteria,3J0QQ@40117|Nitrospirae	40117|Nitrospirae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
LZS2_k127_5789139_2	330214.NIDE2642	7.504e-147	475.0	COG0795@1|root,COG0795@2|Bacteria,3J0S0@40117|Nitrospirae	40117|Nitrospirae	S	Predicted permease YjgP/YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
LZS2_k127_5792440_6	330214.NIDE1510	5.62e-95	317.0	COG0750@1|root,COG0750@2|Bacteria,3J0GI@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
LZS2_k127_5792440_1	330214.NIDE1509	2.968e-262	818.0	COG0442@1|root,COG0442@2|Bacteria,3J0EY@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
LZS2_k127_5792440_0	330214.NIDE1508	0.0	1248.0	COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
LZS2_k127_5792440_3	330214.NIDE1472	3.39e-179	570.0	COG0513@1|root,COG0513@2|Bacteria,3J0ZA@40117|Nitrospirae	40117|Nitrospirae	F	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
LZS2_k127_5792440_9	360106.CFF8240_1240	6.074e-12	68.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2YQAF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	RNA-binding protein	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
LZS2_k127_5792440_12	330214.NIDE3405	2.731e-09	64.0	COG3212@1|root,COG3212@2|Bacteria	2|Bacteria	T	peptidase	Z012_07375	-	-	-	-	-	-	-	-	-	-	-	PepSY
LZS2_k127_5792440_5	479434.Sthe_1967	2.772e-143	468.0	COG3004@1|root,COG3004@2|Bacteria,2G7ZG@200795|Chloroflexi	200795|Chloroflexi	P	) H( ) antiporter that extrudes sodium in exchange for external protons	-	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
LZS2_k127_5792440_13	330214.NIDE3654	1.646e-08	58.0	COG3265@1|root,COG3265@2|Bacteria	2|Bacteria	G	gluconokinase activity	gntK	-	1.1.1.343,1.1.1.44,2.7.1.12,3.1.1.31	ko:K00033,ko:K00851,ko:K01057	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01528,R01737,R02035,R10221	RC00001,RC00002,RC00017,RC00537,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2,SKI
LZS2_k127_5792440_4	42256.RradSPS_0959	2.707e-151	491.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4CPHW@84995|Rubrobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
LZS2_k127_5792440_2	1255043.TVNIR_1112	2.7e-251	788.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
LZS2_k127_5792440_11	1123274.KB899422_gene86	1.82e-10	72.0	COG1295@1|root,COG1295@2|Bacteria,2JAZX@203691|Spirochaetes	203691|Spirochaetes	K	TIGRFAM YihY family protein (not ribonuclease BN)	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
LZS2_k127_5792440_7	930169.B5T_00239	4.626e-36	144.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RN5Z@1236|Gammaproteobacteria,1XI47@135619|Oceanospirillales	135619|Oceanospirillales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
LZS2_k127_5813801_1	330214.NIDE0861	0.0	1087.0	COG1657@1|root,COG1657@2|Bacteria,3J0ZD@40117|Nitrospirae	40117|Nitrospirae	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
LZS2_k127_5813801_12	330214.NIDE0862	4.347e-44	171.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	MA20_16045	-	1.17.7.4,3.2.2.9	ko:K01243,ko:K03527	ko00270,ko00900,ko01100,ko01110,ko01130,ko01230,map00270,map00900,map01100,map01110,map01130,map01230	M00034,M00096,M00609	R00194,R01401,R05884,R08210	RC00063,RC00318,RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
LZS2_k127_5813801_6	330214.NIDE0863	1.613e-126	411.0	COG0767@1|root,COG0767@2|Bacteria,3J0I7@40117|Nitrospirae	40117|Nitrospirae	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
LZS2_k127_5813801_7	330214.NIDE0864	4.561e-124	403.0	COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae	40117|Nitrospirae	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
LZS2_k127_5813801_10	330214.NIDE0865	1.04e-67	232.0	COG1463@1|root,COG1463@2|Bacteria,3J191@40117|Nitrospirae	40117|Nitrospirae	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
LZS2_k127_5813801_8	330214.NIDE0866	1.085e-79	272.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
LZS2_k127_5813801_4	330214.NIDE0867	8.819e-174	555.0	COG4775@1|root,COG4775@2|Bacteria,3J10P@40117|Nitrospirae	40117|Nitrospirae	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
LZS2_k127_5813801_0	330214.NIDE0869	0.0	1115.0	COG1154@1|root,COG1154@2|Bacteria,3J0WE@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
LZS2_k127_5813801_2	330214.NIDE0870	7.632e-216	674.0	COG0821@1|root,COG0821@2|Bacteria,3J0EA@40117|Nitrospirae	40117|Nitrospirae	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
LZS2_k127_5813801_14	344747.PM8797T_08794	3.996e-33	144.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2,PMT_4TMC,PRK
LZS2_k127_5813801_3	330214.NIDE0891	6.887e-203	633.0	COG0535@1|root,COG0535@2|Bacteria,3J0X6@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
LZS2_k127_5813801_13	330214.NIDE0892	2.066e-39	150.0	29E6W@1|root,3014W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5813801_9	330214.NIDE0895	5.632e-69	237.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
LZS2_k127_5813801_5	330214.NIDE0896	1.731e-170	541.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	-	-	1.10.3.14	ko:K00425,ko:K08738	ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00153,M00595	R10151,R11325	RC00061,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3,3.D.4.6	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
LZS2_k127_5817418_1	330214.NIDE3548	4.479e-230	719.0	COG0104@1|root,COG0104@2|Bacteria,3J0FV@40117|Nitrospirae	40117|Nitrospirae	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
LZS2_k127_5817418_0	330214.NIDE3551	9.562e-267	828.0	COG0488@1|root,COG0488@2|Bacteria,3J0W6@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
LZS2_k127_5820329_0	330214.NIDE0678	6.506e-236	743.0	COG2217@1|root,COG2217@2|Bacteria,3J0CY@40117|Nitrospirae	40117|Nitrospirae	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
LZS2_k127_5820329_1	330214.NIDE0677	9.854e-81	274.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	dsbA	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	iEcSMS35_1347.EcSMS35_4241	DSBA
LZS2_k127_5820329_2	330214.NIDE0676	8.132e-15	77.0	COG3065@1|root,COG3065@2|Bacteria,3J1BB@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
LZS2_k127_5906475_0	1340493.JNIF01000003_gene2317	1.652e-61	235.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	RHS_repeat
LZS2_k127_5906475_1	1340493.JNIF01000003_gene2317	2.054e-17	94.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	RHS_repeat
LZS2_k127_5914855_7	330214.NIDE2453	6.721e-60	209.0	COG0071@1|root,COG0071@2|Bacteria,3J0TV@40117|Nitrospirae	40117|Nitrospirae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
LZS2_k127_5914855_3	330214.NIDE2451	1.133e-204	640.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.gltA	Citrate_synt
LZS2_k127_5914855_9	330214.NIDE2447	8.852e-46	168.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,Glutaredoxin
LZS2_k127_5914855_4	330214.NIDE2445	2.035e-152	495.0	COG0349@1|root,COG0349@2|Bacteria	2|Bacteria	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
LZS2_k127_5914855_6	330214.NIDE2444	7.849e-79	268.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516,ko:K05801,ko:K18481	-	M00670	-	-	ko00000,ko00002,ko02000,ko03036,ko03110	3.A.1.27.4,3.A.1.27.5	-	-	DnaJ,DnaJ_C
LZS2_k127_5914855_1	330214.NIDE2442	1.426e-242	756.0	COG0281@1|root,COG0281@2|Bacteria,3J0WV@40117|Nitrospirae	40117|Nitrospirae	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
LZS2_k127_5914855_0	330214.NIDE2440	0.0	1523.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,3J0HX@40117|Nitrospirae	40117|Nitrospirae	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
LZS2_k127_5914855_2	330214.NIDE2415	9.126e-213	672.0	COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,3J0K5@40117|Nitrospirae	2|Bacteria	FP	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ppx	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko02048	-	-	-	HD,Helicase_C,Ppx-GppA,Response_reg
LZS2_k127_5914855_5	485913.Krac_9228	2.034e-81	280.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
LZS2_k127_5935837_0	330214.NIDE4355	1.912e-169	540.0	COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_5935837_1	330214.NIDE4360	3.222e-82	278.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
LZS2_k127_5935837_2	330214.NIDE4362	5.84e-55	196.0	COG1611@1|root,COG1611@2|Bacteria,3J0TX@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
LZS2_k127_5949262_0	330214.NIDE1222	0.0	1151.0	COG5000@1|root,COG5000@2|Bacteria,3J0B7@40117|Nitrospirae	40117|Nitrospirae	T	GHKL domain	-	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
LZS2_k127_5949262_1	330214.NIDE1221	3.903e-40	152.0	2EAFJ@1|root,334IY@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
LZS2_k127_5960465_6	1384054.N790_00235	9.822e-05	47.0	COG2110@1|root,COG2110@2|Bacteria,1MVYN@1224|Proteobacteria,1RNHW@1236|Gammaproteobacteria,1X8TD@135614|Xanthomonadales	135614|Xanthomonadales	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
LZS2_k127_5960465_5	794903.OPIT5_29065	8.327e-08	61.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,FMN_red
LZS2_k127_5960465_4	330214.NIDE4035	7.092e-69	243.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_5960465_0	330214.NIDE3755	0.0	1630.0	COG3696@1|root,COG3696@2|Bacteria	2|Bacteria	P	silver ion transport	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
LZS2_k127_5960465_2	330214.NIDE3756	7.924e-126	420.0	COG0845@1|root,COG0845@2|Bacteria,3J15V@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	HlyD_D23
LZS2_k127_5960465_1	330214.NIDE3604	1.227e-164	526.0	COG0435@1|root,COG0435@2|Bacteria	2|Bacteria	O	Glutathione S-transferase	yqjG	GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.5.7,2.5.1.18	ko:K00799,ko:K07393	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	iECW_1372.ECW_m3373,iWFL_1372.ECW_m3373	GST_C_2,GST_N_2
LZS2_k127_5960465_3	330214.NIDE3757	8.312e-76	263.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_5960537_0	671143.DAMO_0414	1.387e-293	922.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
LZS2_k127_5960537_1	671143.DAMO_0415	2.605e-88	304.0	COG0745@1|root,COG0745@2|Bacteria,2NQWD@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
LZS2_k127_5962397_3	330214.NIDE4181	1.785e-19	100.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	2.7.13.3	ko:K03407,ko:K03832	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035	2.C.1.1	-	-	CarbopepD_reg_2,GUN4,Gram_pos_anchor,HAMP,NIT,TonB_2,TonB_C,Trypsin_2
LZS2_k127_5962397_1	330214.NIDE4180	1.262e-81	284.0	COG2353@1|root,COG2353@2|Bacteria	2|Bacteria	O	YceI-like domain	Cj0420	-	-	-	-	-	-	-	-	-	-	-	YceI
LZS2_k127_5962397_0	1303518.CCALI_01155	2.686e-129	420.0	COG1064@1|root,COG1064@2|Bacteria	2|Bacteria	P	alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
LZS2_k127_5962397_2	1235457.C404_18115	1.516e-48	181.0	2EQUS@1|root,33KPM@2|Bacteria,1QY6Y@1224|Proteobacteria,2WHCE@28216|Betaproteobacteria,1KIKY@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5974491_5	330214.NIDE0602	4.299e-132	430.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_5974491_3	330214.NIDE0603	7.06e-231	725.0	COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_5974491_1	330214.NIDE0604	1.948e-317	981.0	COG1009@1|root,COG1009@2|Bacteria,3J0AN@40117|Nitrospirae	2|Bacteria	CP	NADH-quinone oxidoreductase	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
LZS2_k127_5974491_9	330214.NIDE0605	6.044e-37	141.0	COG0713@1|root,COG0713@2|Bacteria,3J0SN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
LZS2_k127_5974491_8	330214.NIDE0606	3.038e-55	198.0	COG0839@1|root,COG0839@2|Bacteria,3J0RP@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
LZS2_k127_5974491_6	330214.NIDE0607	6.753e-110	359.0	COG1143@1|root,COG1143@2|Bacteria,3J0N0@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
LZS2_k127_5974491_4	330214.NIDE0608	1.35e-188	593.0	COG1005@1|root,COG1005@2|Bacteria,3J0E2@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
LZS2_k127_5974491_0	330214.NIDE0609	0.0	1260.0	COG3383@1|root,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	40117|Nitrospirae	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
LZS2_k127_5974491_2	330214.NIDE0611	1.584e-250	777.0	COG1894@1|root,COG1894@2|Bacteria,3J0WX@40117|Nitrospirae	40117|Nitrospirae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
LZS2_k127_5974491_7	330214.NIDE0612	4.432e-92	304.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3,1.6.99.3	ko:K00334,ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143,M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.1.6	-	-	2Fe-2S_thioredx
LZS2_k127_5979142_1	1458357.BG58_15470	4.188e-174	577.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,1K29X@119060|Burkholderiaceae	28216|Betaproteobacteria	T	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,PAS_3,PAS_9,TarH
LZS2_k127_5979142_4	330214.NIDE2362	3.367e-80	271.0	COG0835@1|root,COG0835@2|Bacteria,3J0PG@40117|Nitrospirae	40117|Nitrospirae	NT	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
LZS2_k127_5979142_0	1026882.MAMP_01679	1.411e-180	590.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4608D@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
LZS2_k127_5979142_5	330214.NIDE2360	7.49e-52	186.0	COG0745@1|root,COG0745@2|Bacteria,3J18A@40117|Nitrospirae	40117|Nitrospirae	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
LZS2_k127_5979142_6	330214.NIDE2359	1.775e-07	60.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
LZS2_k127_5979142_3	330214.NIDE2357	5.898e-85	289.0	COG1360@1|root,COG1360@2|Bacteria,3J0MN@40117|Nitrospirae	40117|Nitrospirae	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
LZS2_k127_5979142_2	330214.NIDE2356	1.63e-125	405.0	COG1291@1|root,COG1291@2|Bacteria,3J0KF@40117|Nitrospirae	40117|Nitrospirae	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
LZS2_k127_5995948_7	485918.Cpin_3771	1.616e-53	196.0	COG0702@1|root,COG0702@2|Bacteria,4NMI5@976|Bacteroidetes,1ISGN@117747|Sphingobacteriia	976|Bacteroidetes	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
LZS2_k127_5995948_6	330214.NIDE1847	1.993e-59	216.0	2DQ7E@1|root,3353C@2|Bacteria,3J1EM@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
LZS2_k127_5995948_4	330214.NIDE1848	2.406e-91	304.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	DUF3386,Kelch_1,Kelch_4,Kelch_5,fn3
LZS2_k127_5995948_11	330214.NIDE1850	2.716e-26	110.0	COG2127@1|root,COG2127@2|Bacteria	2|Bacteria	T	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
LZS2_k127_5995948_2	330214.NIDE1853	7.153e-102	344.0	COG0635@1|root,COG0635@2|Bacteria,3J10W@40117|Nitrospirae	40117|Nitrospirae	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
LZS2_k127_5995948_10	330214.NIDE1855	4.497e-28	119.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
LZS2_k127_5995948_1	330214.NIDE1860	2.47e-130	423.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_5995948_5	330214.NIDE1861	1.461e-88	298.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
LZS2_k127_5995948_8	330214.NIDE1862	7.459e-42	155.0	2CC8H@1|root,330SM@2|Bacteria,3J1D6@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5995948_3	330214.NIDE1867	7.464e-96	320.0	2FKUS@1|root,34CF5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_5995948_0	330214.NIDE1868	0.0	1031.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,3J0UH@40117|Nitrospirae	40117|Nitrospirae	H	Pterin binding enzyme	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
LZS2_k127_6026799_12	1234664.AMRO01000019_gene754	5.787e-69	247.0	COG0584@1|root,COG3540@1|root,COG0584@2|Bacteria,COG3540@2|Bacteria,1UY23@1239|Firmicutes,4HEAD@91061|Bacilli,1WHRB@129337|Geobacillus	91061|Bacilli	C	Glycerophosphoryl diester phosphodiesterase family	glpQ	-	3.1.3.1,3.1.4.46	ko:K01113,ko:K01126	ko00564,ko00790,ko01100,ko02020,map00564,map00790,map01100,map02020	M00126	R01030,R01470,R04620	RC00017,RC00425	ko00000,ko00001,ko00002,ko01000	-	-	-	GDPD
LZS2_k127_6026799_8	330214.NIDE1396	3.979e-95	322.0	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
LZS2_k127_6026799_7	330214.NIDE1397	6.196e-101	344.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
LZS2_k127_6026799_18	330214.NIDE1394	1.535e-34	138.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,TPR_19,TPR_8,Transglut_core
LZS2_k127_6026799_5	111780.Sta7437_0768	2.597e-167	545.0	COG1132@1|root,COG1132@2|Bacteria,1G0C0@1117|Cyanobacteria,3VJIT@52604|Pleurocapsales	1117|Cyanobacteria	V	COGs COG1132 ABC-type multidrug transport system ATPase and permease components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
LZS2_k127_6026799_3	686340.Metal_1038	2.167e-185	584.0	COG0823@1|root,COG0823@2|Bacteria,1NCYN@1224|Proteobacteria,1SJ96@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
LZS2_k127_6026799_15	392500.Swoo_3906	7.103e-46	169.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S4I5@1236|Gammaproteobacteria,2QEGE@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
LZS2_k127_6026799_4	330214.NIDE1059	1.086e-168	536.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	1.5.99.5,2.1.2.10	ko:K00605,ko:K06980,ko:K22086	ko00260,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200	M00532	R00609,R01221,R02300,R04125	RC00022,RC00069,RC00183,RC00190,RC00557,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
LZS2_k127_6026799_16	330214.NIDE1060	1.393e-45	168.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
LZS2_k127_6026799_9	330214.NIDE1061	1.728e-89	298.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	sscB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
LZS2_k127_6026799_6	330214.NIDE1062	3.257e-154	488.0	COG1635@1|root,COG1635@2|Bacteria	2|Bacteria	H	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur	thi4	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K03146	ko00730,ko01100,map00730,map01100	-	R10685	RC00033,RC03253,RC03254	ko00000,ko00001	-	-	-	FAD_oxidored,Thi4
LZS2_k127_6026799_1	1123257.AUFV01000009_gene2282	2.154e-311	965.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1X4N0@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
LZS2_k127_6026799_2	330214.NIDE1076	1.209e-207	649.0	COG0379@1|root,COG0379@2|Bacteria,3J0NV@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
LZS2_k127_6026799_0	330214.NIDE1077	0.0	1540.0	COG0060@1|root,COG0060@2|Bacteria,3J0BF@40117|Nitrospirae	40117|Nitrospirae	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
LZS2_k127_6026799_13	330214.NIDE1078	3.148e-68	236.0	COG0597@1|root,COG0597@2|Bacteria,3J0S2@40117|Nitrospirae	40117|Nitrospirae	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
LZS2_k127_6026799_14	858215.Thexy_1097	4.009e-65	237.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,42FMJ@68295|Thermoanaerobacterales	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
LZS2_k127_6026799_11	330214.NIDE1081	4.237e-73	252.0	COG1196@1|root,COG1555@1|root,COG1196@2|Bacteria,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
LZS2_k127_6027593_2	330214.NIDE4057	3.051e-57	201.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
LZS2_k127_6027593_1	1415778.JQMM01000001_gene2119	1.234e-88	308.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
LZS2_k127_6027593_0	330214.NIDE0186	1.811e-225	709.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
LZS2_k127_6027593_4	640081.Dsui_0182	0.0003226	51.0	28UWE@1|root,2ZH0C@2|Bacteria,1P5ZN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6077206_3	330214.NIDE0972	1.455e-123	397.0	COG0226@1|root,COG0226@2|Bacteria,3J0YH@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	-	-	-	-	-	-	-	-	-	CO_dh
LZS2_k127_6077206_0	330214.NIDE0971	2.022e-258	797.0	COG0674@1|root,COG0674@2|Bacteria,3J0WN@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
LZS2_k127_6077206_1	330214.NIDE0970	1.441e-187	587.0	COG1013@1|root,COG1013@2|Bacteria,3J0Z2@40117|Nitrospirae	40117|Nitrospirae	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
LZS2_k127_6077206_2	330214.NIDE0969	3.931e-140	446.0	COG1014@1|root,COG1014@2|Bacteria,3J0Y6@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
LZS2_k127_6077206_4	330214.NIDE0968	2.327e-48	173.0	COG1144@1|root,COG1144@2|Bacteria,3J1DG@40117|Nitrospirae	40117|Nitrospirae	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6077206_6	1122236.KB905141_gene1132	5.533e-25	109.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2VI7W@28216|Betaproteobacteria,2KNHB@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
LZS2_k127_6087708_1	330214.NIDE1465	3.395e-62	214.0	COG1013@1|root,COG1013@2|Bacteria,3J10F@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
LZS2_k127_6087708_0	330214.NIDE0971	5.31e-229	716.0	COG0674@1|root,COG0674@2|Bacteria,3J0WN@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
LZS2_k127_6087708_2	330214.NIDE1460	1.73e-57	201.0	COG0316@1|root,COG0316@2|Bacteria,3J0TZ@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the HesB IscA family	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
LZS2_k127_6099128_2	330214.NIDE0483	1.857e-112	367.0	COG4992@1|root,COG4992@2|Bacteria,3J0AB@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
LZS2_k127_6099128_5	330214.NIDE0482	7.583e-60	213.0	COG4969@1|root,COG4969@2|Bacteria	2|Bacteria	NU	cell adhesion	pilA	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	DUF2628,N_methyl,Pilin
LZS2_k127_6099128_3	330214.NIDE0478	6.212e-111	360.0	COG0588@1|root,COG0588@2|Bacteria,3J118@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
LZS2_k127_6099128_7	330214.NIDE0266	2.665e-35	151.0	COG1360@1|root,COG4942@1|root,COG1360@2|Bacteria,COG4942@2|Bacteria	2|Bacteria	D	peptidase	motB	-	-	ko:K02557,ko:K21471	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011,ko02000,ko02035	1.A.30.1	-	-	OmpA
LZS2_k127_6099128_1	316067.Geob_3189	6.876e-136	451.0	COG3673@1|root,COG3673@2|Bacteria,1NFRW@1224|Proteobacteria,42TBM@68525|delta/epsilon subdivisions,2WP92@28221|Deltaproteobacteria,43V6A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterized alpha/beta hydrolase domain (DUF2235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235
LZS2_k127_6099128_6	1366050.N234_30565	6.069e-37	144.0	COG2913@1|root,COG2913@2|Bacteria,1RJS2@1224|Proteobacteria,2VW4K@28216|Betaproteobacteria,1K9P3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Protein of unknown function (DUF3574)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3574
LZS2_k127_6099128_0	330214.NIDE0947	3.716e-243	779.0	COG3829@1|root,COG4252@1|root,COG3829@2|Bacteria,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	-	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	CHASE2,HTH_8,Sigma54_activat
LZS2_k127_6099128_4	330214.NIDE0948	9.322e-85	295.0	COG0457@1|root,COG0790@1|root,COG0457@2|Bacteria,COG0790@2|Bacteria,3J1CG@40117|Nitrospirae	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K02450,ko:K07126	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	Sel1
LZS2_k127_6099700_5	330214.NIDE3973	2.994e-09	59.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
LZS2_k127_6099700_1	330214.NIDE3974	7.316e-207	653.0	COG1012@1|root,COG1012@2|Bacteria,3J0YN@40117|Nitrospirae	40117|Nitrospirae	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
LZS2_k127_6099700_3	330214.NIDE3976	1.674e-85	291.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
LZS2_k127_6099700_2	330214.NIDE3977	1.394e-186	588.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
LZS2_k127_6099700_0	330214.NIDE2737	2.17e-322	995.0	COG0465@1|root,COG0465@2|Bacteria,3J0AG@40117|Nitrospirae	40117|Nitrospirae	D	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
LZS2_k127_6120678_0	1499967.BAYZ01000005_gene5452	4.617e-241	771.0	COG4096@1|root,COG4096@2|Bacteria,2NQH5@2323|unclassified Bacteria	2|Bacteria	V	Type I restriction enzyme R protein N terminus (HSDR_N)	hsdR_2	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
LZS2_k127_6120678_2	497964.CfE428DRAFT_1563	3.205e-09	60.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
LZS2_k127_6120678_1	330214.NIDE2373	1.145e-31	124.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6200836_1	330214.NIDE3710	1.792e-32	128.0	COG0640@1|root,COG0640@2|Bacteria,3J1BW@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
LZS2_k127_6200836_0	330214.NIDE3709	2.407e-48	177.0	COG0500@1|root,COG2226@2|Bacteria,3J12W@40117|Nitrospirae	40117|Nitrospirae	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
LZS2_k127_6271335_2	330214.NIDE0396	1.03e-84	291.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,3J136@40117|Nitrospirae	40117|Nitrospirae	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
LZS2_k127_6271335_0	330214.NIDE0395	6.559e-136	438.0	COG0223@1|root,COG0223@2|Bacteria,3J0GW@40117|Nitrospirae	40117|Nitrospirae	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
LZS2_k127_6271335_3	247633.GP2143_00482	4.335e-09	58.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6271335_1	247490.KSU1_C0207	6.345e-127	415.0	COG4974@1|root,COG4974@2|Bacteria,2J296@203682|Planctomycetes	203682|Planctomycetes	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
LZS2_k127_629624_1	330214.NIDE3190	6.169e-71	251.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
LZS2_k127_629624_3	330214.NIDE3327	1.205e-42	160.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
LZS2_k127_629624_0	330214.NIDE3077	0.0	1130.0	COG0556@1|root,COG0556@2|Bacteria,3J0FS@40117|Nitrospirae	40117|Nitrospirae	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
LZS2_k127_629624_4	330214.NIDE3076	5.766e-31	124.0	29W29@1|root,30HKU@2|Bacteria,3J1EN@40117|Nitrospirae	40117|Nitrospirae	S	Domain of unknown function (DUF4321)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4321
LZS2_k127_6311668_3	395494.Galf_0055	1.8e-32	129.0	COG5562@1|root,COG5562@2|Bacteria,1N9UF@1224|Proteobacteria,2W3SZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phage envelope protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1398
LZS2_k127_6311668_1	1162668.LFE_1605	1.779e-63	219.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
LZS2_k127_6311668_2	1125863.JAFN01000001_gene3529	1.074e-32	133.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2WNPI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ada_Zn_binding,Excalibur,SNase
LZS2_k127_6311668_5	41431.PCC8801_2257	4.305e-21	94.0	COG0298@1|root,COG0298@2|Bacteria,1G9FZ@1117|Cyanobacteria,3KIER@43988|Cyanothece	1117|Cyanobacteria	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
LZS2_k127_6311668_0	518766.Rmar_2593	9.658e-235	751.0	COG0068@1|root,COG0068@2|Bacteria,4NIZ1@976|Bacteroidetes	976|Bacteroidetes	O	Belongs to the carbamoyltransferase HypF family	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
LZS2_k127_6311668_6	107635.AZUO01000001_gene531	5.688e-09	62.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,2UBR0@28211|Alphaproteobacteria,36YPP@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
LZS2_k127_6311668_4	272134.KB731324_gene5865	6.901e-28	119.0	COG0680@1|root,COG0680@2|Bacteria,1G5ZU@1117|Cyanobacteria,1HBCF@1150|Oscillatoriales	1117|Cyanobacteria	C	Hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	HycI
LZS2_k127_6366633_8	330214.NIDE3306	3.203e-27	111.0	COG2322@1|root,COG2322@2|Bacteria	2|Bacteria	S	membrane	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
LZS2_k127_6366633_1	330214.NIDE3307	4.875e-144	463.0	COG2813@1|root,COG2813@2|Bacteria	2|Bacteria	J	rRNA (guanine-N2-)-methyltransferase activity	crtF	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.210,2.1.1.304,2.1.1.333	ko:K09846,ko:K13604,ko:K21460	ko00860,ko00906,ko01100,ko01110,map00860,map00906,map01100,map01110	-	R07521,R07524,R07527,R07529,R07533,R07535,R09063	RC00003,RC01662,RC02082	ko00000,ko00001,ko01000	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
LZS2_k127_6366633_2	330214.NIDE3308	9.001e-136	436.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
LZS2_k127_6366633_3	330214.NIDE1497	2.203e-134	433.0	COG1398@1|root,COG1398@2|Bacteria	2|Bacteria	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
LZS2_k127_6366633_7	2002.JOEQ01000016_gene7331	3.811e-34	144.0	COG0829@1|root,COG0829@2|Bacteria,2HHBD@201174|Actinobacteria,4EM89@85012|Streptosporangiales	201174|Actinobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
LZS2_k127_6366633_4	1121346.KB899840_gene1144	2.074e-83	285.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,4HC5C@91061|Bacilli,26RAX@186822|Paenibacillaceae	91061|Bacilli	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
LZS2_k127_6366633_9	868595.Desca_0747	8.617e-24	110.0	COG0830@1|root,COG0830@2|Bacteria,1V2H0@1239|Firmicutes,24ETM@186801|Clostridia,262PC@186807|Peptococcaceae	186801|Clostridia	J	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
LZS2_k127_6366633_0	1173022.Cri9333_2537	1.007e-290	900.0	COG0804@1|root,COG0804@2|Bacteria,1G12D@1117|Cyanobacteria,1H6ZH@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
LZS2_k127_6366633_6	1128421.JAGA01000002_gene361	4.779e-38	148.0	COG0832@1|root,COG0832@2|Bacteria	2|Bacteria	E	Belongs to the urease beta subunit family	ureB	GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009039,GO:0016787,GO:0016810,GO:0016811	3.5.1.5	ko:K01427,ko:K01428,ko:K01429,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_1322,iECO103_1326.ECO103_3798,iECO111_1330.ECO111_1228,iECSP_1301.ECSP_1250,iECs_1301.ECs1323,iUMNK88_1353.UMNK88_1200,iZ_1308.Z1144,iZ_1308.Z1583	Urease_beta,Urease_gamma
LZS2_k127_6366633_5	635013.TherJR_0605	5.629e-44	161.0	COG0831@1|root,COG0831@2|Bacteria,1V7GU@1239|Firmicutes,24MN2@186801|Clostridia,262GQ@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM Urease, alpha gamma subunit	ureA	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_gamma
LZS2_k127_6380153_1	330214.NIDE2035	6.59e-68	233.0	COG1253@1|root,COG1253@2|Bacteria,3J0KN@40117|Nitrospirae	40117|Nitrospirae	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
LZS2_k127_6380153_0	330214.NIDE2036	2.768e-293	914.0	COG0272@1|root,COG0272@2|Bacteria,3J0W8@40117|Nitrospirae	40117|Nitrospirae	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
LZS2_k127_6418560_2	330214.NIDE1807	1.007e-117	385.0	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS2_k127_6418560_4	330214.NIDE1806	9.704e-84	281.0	COG0242@1|root,COG0242@2|Bacteria,3J146@40117|Nitrospirae	40117|Nitrospirae	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
LZS2_k127_6418560_3	330214.NIDE1805	1.248e-103	343.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,zf-HC2
LZS2_k127_6418560_1	330214.NIDE1796	4.561e-227	709.0	COG0448@1|root,COG0448@2|Bacteria,3J0BI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
LZS2_k127_6418560_0	330214.NIDE1795	2.545e-255	797.0	COG4581@1|root,COG4581@2|Bacteria	2|Bacteria	L	dead DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
LZS2_k127_6471199_0	330214.NIDE2086	5.121e-127	422.0	COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae	40117|Nitrospirae	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
LZS2_k127_6471199_3	330214.NIDE4157	4.699e-40	154.0	COG3824@1|root,COG3824@2|Bacteria	2|Bacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
LZS2_k127_6471199_1	330214.NIDE2088	9.24e-117	381.0	COG0682@1|root,COG0682@2|Bacteria,3J0G4@40117|Nitrospirae	40117|Nitrospirae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
LZS2_k127_6471199_4	330214.NIDE2089	9.872e-16	80.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
LZS2_k127_6471199_2	330214.NIDE2529	1.777e-50	183.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	gspA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,NB-ARC,PG_binding_1,TPR_10,TniB
LZS2_k127_6527597_0	1131814.JAFO01000001_gene3315	0.0	2542.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,3EYBF@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
LZS2_k127_6527597_4	330214.NIDE0866	2.395e-40	158.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
LZS2_k127_6527597_6	573370.DMR_32610	3.351e-14	74.0	COG1555@1|root,COG1555@2|Bacteria,1N7MI@1224|Proteobacteria	1224|Proteobacteria	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
LZS2_k127_6527597_7	1209072.ALBT01000008_gene2953	3.577e-11	64.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,1TB8R@1236|Gammaproteobacteria,1FIGQ@10|Cellvibrio	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
LZS2_k127_6527597_11	338966.Ppro_1722	0.000683	47.0	COG4980@1|root,COG4980@2|Bacteria,1NEPD@1224|Proteobacteria,42WE2@68525|delta/epsilon subdivisions,2WRDT@28221|Deltaproteobacteria,43SRZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
LZS2_k127_6527597_3	666685.R2APBS1_0366	2.089e-50	184.0	COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,1S2G2@1236|Gammaproteobacteria,1X60R@135614|Xanthomonadales	135614|Xanthomonadales	P	Bacterioferritin (cytochrome b1)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
LZS2_k127_6527597_8	420324.KI911965_gene513	1.097e-10	66.0	COG1961@1|root,COG3293@1|root,COG1961@2|Bacteria,COG3293@2|Bacteria,1QXE6@1224|Proteobacteria,2TX8K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
LZS2_k127_6527597_9	589865.DaAHT2_1072	4.586e-08	59.0	COG4980@1|root,COG4980@2|Bacteria,1NB49@1224|Proteobacteria,42W0M@68525|delta/epsilon subdivisions,2WRVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
LZS2_k127_6527597_5	330214.NIDE2917	7.225e-29	120.0	COG4768@1|root,COG4768@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF948)	WQ51_05790	-	-	-	-	-	-	-	-	-	-	-	DUF948
LZS2_k127_6527597_1	1163409.UUA_14514	3.458e-73	252.0	COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,1S2G2@1236|Gammaproteobacteria,1X60R@135614|Xanthomonadales	135614|Xanthomonadales	P	Bacterioferritin (cytochrome b1)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
LZS2_k127_6527597_2	404589.Anae109_1904	1.751e-52	190.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
LZS2_k127_6549468_0	330214.NIDE1205	1.179e-265	826.0	COG0439@1|root,COG0439@2|Bacteria,3J0YP@40117|Nitrospirae	40117|Nitrospirae	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
LZS2_k127_6549468_1	330214.NIDE1204	1.313e-140	455.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,3J10I@40117|Nitrospirae	40117|Nitrospirae	C	Conserved carboxylase domain	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
LZS2_k127_6552761_12	335543.Sfum_1451	6.789e-05	49.0	2DD8H@1|root,2ZH1Z@2|Bacteria,1PBE0@1224|Proteobacteria,432B3@68525|delta/epsilon subdivisions,2WY4T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6552761_5	330214.NIDE1495	3.237e-47	171.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
LZS2_k127_6552761_1	330214.NIDE1110	1.445e-71	248.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	narP	-	-	ko:K02479,ko:K07685	ko02020,map02020	M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
LZS2_k127_6552761_9	1122605.KB893646_gene213	2.22e-23	105.0	COG1525@1|root,COG1525@2|Bacteria,4NT0S@976|Bacteroidetes,1IUAB@117747|Sphingobacteriia	976|Bacteroidetes	L	Staphylococcal nuclease homologues	lpxP	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	SNase
LZS2_k127_6552761_3	330214.NIDE0942	1.975e-64	229.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OMP_b-brl,OmpA
LZS2_k127_6552761_14	644966.Tmar_1677	0.0001227	51.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
LZS2_k127_6552761_0	1396418.BATQ01000115_gene4612	2.381e-173	552.0	COG0297@1|root,COG0297@2|Bacteria,46Z3D@74201|Verrucomicrobia,2IUHH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS2_k127_6552761_4	330214.NIDE3312	1.002e-53	199.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,fn3_3
LZS2_k127_6552761_10	323261.Noc_2233	2.697e-17	84.0	2EHHF@1|root,33B9C@2|Bacteria,1NM2H@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6552761_2	330214.NIDE4140	2.501e-68	232.0	COG1145@1|root,COG1145@2|Bacteria,3J1BF@40117|Nitrospirae	40117|Nitrospirae	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6552761_13	1045855.DSC_03830	0.0001073	46.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,1RREG@1236|Gammaproteobacteria,1X58C@135614|Xanthomonadales	135614|Xanthomonadales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
LZS2_k127_6566058_0	330214.NIDE3623	3.614e-134	432.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	ytbE	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,DUF4157
LZS2_k127_6566058_5	639030.JHVA01000001_gene3379	3.692e-39	150.0	COG3189@1|root,COG3189@2|Bacteria,3Y88F@57723|Acidobacteria,2JN90@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
LZS2_k127_6566058_4	1162668.LFE_1587	4.861e-46	171.0	29KDN@1|root,307AY@2|Bacteria,3J14Y@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6566058_1	479437.Elen_1473	9.853e-72	247.0	COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria,4CVW0@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA-3-methyladenine glycosylase I	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
LZS2_k127_6566058_2	330214.NIDE2809	5.481e-61	216.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
LZS2_k127_6566058_3	330214.NIDE2808	2.507e-58	208.0	COG1595@1|root,COG1595@2|Bacteria,3J17D@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_6607492_22	330214.NIDE1125	1.529e-06	50.0	COG0301@1|root,COG0301@2|Bacteria	2|Bacteria	H	tRNA thio-modification	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
LZS2_k127_6607492_6	330214.NIDE1740	2.339e-185	592.0	COG2251@1|root,COG2251@2|Bacteria	2|Bacteria	-	-	nusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF2779,HHH_5,KH_5,NusA_N,S1
LZS2_k127_6607492_4	330214.NIDE1739	2.251e-214	672.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
LZS2_k127_6607492_2	1210884.HG799463_gene9874	5.919e-312	972.0	COG0288@1|root,COG0659@1|root,COG0288@2|Bacteria,COG0659@2|Bacteria,2IY7T@203682|Planctomycetes	203682|Planctomycetes	P	COG0659 Sulfate permease and related transporters (MFS	-	-	4.2.1.1	ko:K01673,ko:K03321	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000,ko02000	2.A.53.3	-	-	Pro_CA,Sulfate_transp
LZS2_k127_6607492_21	314230.DSM3645_20792	1.305e-45	174.0	2CNMZ@1|root,32SHD@2|Bacteria,2J3XH@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6607492_3	330214.NIDE1738	9.017e-220	692.0	COG1893@1|root,COG2041@1|root,COG1893@2|Bacteria,COG2041@2|Bacteria,3J0S5@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
LZS2_k127_6607492_9	330214.NIDE1737	2.605e-115	376.0	COG0846@1|root,COG0846@2|Bacteria,3J15J@40117|Nitrospirae	40117|Nitrospirae	K	Belongs to the sirtuin family. Class	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
LZS2_k127_6607492_20	1337936.IJ00_11775	6.312e-46	174.0	COG1011@1|root,COG1011@2|Bacteria,1G51I@1117|Cyanobacteria,1HJ2D@1161|Nostocales	1117|Cyanobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase
LZS2_k127_6607492_15	330214.NIDE1735	6.11e-82	286.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	VP1245	-	-	-	-	-	-	-	-	-	-	-	DUF3369,EAL,GAF_2,GGDEF,HATPase_c,HD,HisKA,Response_reg,cNMP_binding
LZS2_k127_6607492_0	330214.NIDE1733	0.0	1204.0	COG0525@1|root,COG0525@2|Bacteria,3J0B9@40117|Nitrospirae	40117|Nitrospirae	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
LZS2_k127_6607492_14	330214.NIDE1732	2.817e-87	297.0	COG0157@1|root,COG0157@2|Bacteria,3J0JY@40117|Nitrospirae	40117|Nitrospirae	H	Quinolinate phosphoribosyl transferase, C-terminal domain	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
LZS2_k127_6607492_18	330214.NIDE1731	3.992e-60	217.0	COG0340@1|root,COG0340@2|Bacteria,3J0U2@40117|Nitrospirae	40117|Nitrospirae	H	Biotin/lipoate A/B protein ligase family	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
LZS2_k127_6607492_13	330214.NIDE1730	4.726e-101	335.0	COG1521@1|root,COG1521@2|Bacteria,3J0TR@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
LZS2_k127_6607492_17	330214.NIDE1729	5.513e-61	217.0	COG0576@1|root,COG0576@2|Bacteria,3J0QP@40117|Nitrospirae	40117|Nitrospirae	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
LZS2_k127_6607492_1	330214.NIDE1728	0.0	1114.0	COG0443@1|root,COG0443@2|Bacteria,3J0D2@40117|Nitrospirae	40117|Nitrospirae	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
LZS2_k127_6607492_8	1232410.KI421424_gene1723	4.041e-123	405.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,43SEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	DnaJ central domain	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
LZS2_k127_6607492_16	330214.NIDE1726	2.285e-61	220.0	COG1385@1|root,COG1385@2|Bacteria,3J18K@40117|Nitrospirae	40117|Nitrospirae	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
LZS2_k127_6607492_11	330214.NIDE1725	1.055e-108	361.0	COG4447@1|root,COG4447@2|Bacteria,3J16A@40117|Nitrospirae	40117|Nitrospirae	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
LZS2_k127_6607492_5	330214.NIDE1724	1.912e-210	668.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,DUF3494,Glug,TIG
LZS2_k127_6607492_19	330214.NIDE1723	1.066e-58	207.0	COG0251@1|root,COG0251@2|Bacteria,3J144@40117|Nitrospirae	40117|Nitrospirae	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
LZS2_k127_6607492_10	330214.NIDE1711	5.221e-110	367.0	COG1015@1|root,COG1015@2|Bacteria	2|Bacteria	G	phosphopentomutase activity	deoB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165	Metalloenzyme
LZS2_k127_6607492_12	330214.NIDE1710	2.712e-103	339.0	COG0274@1|root,COG0274@2|Bacteria	2|Bacteria	F	deoxyribose-phosphate aldolase activity	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
LZS2_k127_6607492_7	330214.NIDE1709	1.951e-130	425.0	COG1559@1|root,COG1559@2|Bacteria,3J0IR@40117|Nitrospirae	40117|Nitrospirae	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
LZS2_k127_6607492_24	330214.NIDE1708	8.878e-06	51.0	COG0816@1|root,COG0816@2|Bacteria,3J1AR@40117|Nitrospirae	40117|Nitrospirae	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
LZS2_k127_6628184_8	330214.NIDE2246	2.862e-43	161.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
LZS2_k127_6628184_9	330214.NIDE2246	5.312e-32	127.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
LZS2_k127_6628184_7	211165.AJLN01000116_gene3212	1.623e-53	194.0	COG0454@1|root,COG0456@2|Bacteria,1G5GC@1117|Cyanobacteria,1JJAJ@1189|Stigonemataceae	1117|Cyanobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
LZS2_k127_6628184_12	330214.NIDE1763	3.807e-24	107.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HisKA,LpxC,PAS_3,Response_reg
LZS2_k127_6628184_6	330214.NIDE1259	3.416e-81	288.0	2AKRW@1|root,31BIT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6628184_10	330214.NIDE1258	4.949e-31	127.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
LZS2_k127_6628184_2	330214.NIDE1256	1.462e-211	667.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_6628184_4	330214.NIDE1255	4.726e-135	440.0	COG4191@1|root,COG4191@2|Bacteria,3J14D@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
LZS2_k127_6628184_1	330214.NIDE1254	6.207e-255	806.0	COG1640@1|root,COG1640@2|Bacteria,3J106@40117|Nitrospirae	40117|Nitrospirae	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
LZS2_k127_6628184_5	330214.NIDE2718	9.191e-131	431.0	COG1538@1|root,COG1538@2|Bacteria,3J19C@40117|Nitrospirae	40117|Nitrospirae	MU	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	OEP
LZS2_k127_6628184_3	330214.NIDE3456	1.725e-191	607.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	hlyD	-	-	ko:K02022,ko:K11003,ko:K12532	ko02020,ko03070,ko05133,map02020,map03070,map05133	M00325,M00326,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1,8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
LZS2_k127_6628184_0	330214.NIDE3457	0.0	1073.0	COG2274@1|root,COG2274@2|Bacteria	2|Bacteria	V	protein secretion by the type I secretion system	hlyB	-	-	ko:K11004	ko02010,ko03070,ko05133,map02010,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.1,3.A.1.109.2	-	-	ABC_membrane,ABC_tran,Peptidase_C39
LZS2_k127_6637651_1	330214.NIDE4374	5.645e-22	97.0	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	rmlD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
LZS2_k127_6637651_0	330214.NIDE4372	7.158e-90	303.0	COG3752@1|root,COG3752@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
LZS2_k127_6637651_2	443143.GM18_1407	7.546e-10	63.0	2EQIW@1|root,33I4X@2|Bacteria,1P5T0@1224|Proteobacteria,432D5@68525|delta/epsilon subdivisions,2WX86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6722304_0	1267535.KB906767_gene2749	6.103e-108	357.0	COG3620@1|root,COG3620@2|Bacteria,3Y6X6@57723|Acidobacteria	57723|Acidobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
LZS2_k127_6722304_1	330214.NIDE0607	8.056e-91	302.0	COG1143@1|root,COG1143@2|Bacteria,3J0N0@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
LZS2_k127_6725615_1	383372.Rcas_3540	9.449e-22	98.0	COG0855@1|root,COG0855@2|Bacteria,2G68J@200795|Chloroflexi,374Y0@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
LZS2_k127_6762677_0	330214.NIDE3454	1.518e-53	200.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
LZS2_k127_6762677_1	330214.NIDE1672	2.544e-41	158.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	Enterotoxin_a,HTH_3,HTH_31,N_BRCA1_IG
LZS2_k127_6762677_3	330214.NIDE1675	5.965e-15	81.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	2.1.1.170,2.1.1.185	ko:K03218,ko:K03437,ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03016,ko03036	-	-	-	SpoU_methylase,SpoU_sub_bind
LZS2_k127_6763560_0	330214.NIDE4071	1.044e-207	655.0	COG0514@1|root,COG0514@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase (RecQ)	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
LZS2_k127_6763560_1	1056820.KB900699_gene1339	0.0009163	43.0	COG2755@1|root,COG2755@2|Bacteria,1RBSB@1224|Proteobacteria,1SG2D@1236|Gammaproteobacteria,2PPI7@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_10,CBM_2,Lipase_GDSL_2
LZS2_k127_6793360_0	330214.NIDE2324	1.17e-103	350.0	COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
LZS2_k127_6793360_1	330214.NIDE2325	1.114e-31	128.0	COG5581@1|root,COG5581@2|Bacteria	2|Bacteria	M	regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
LZS2_k127_6808297_4	118166.JH976538_gene5040	2.69e-193	622.0	COG0419@1|root,COG0419@2|Bacteria,1GHIS@1117|Cyanobacteria,1HF5W@1150|Oscillatoriales	1117|Cyanobacteria	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6808297_1	118166.JH976538_gene5041	9.892e-241	779.0	COG0222@1|root,COG0845@1|root,COG0222@2|Bacteria,COG0845@2|Bacteria,1GBZT@1117|Cyanobacteria,1HEC7@1150|Oscillatoriales	1117|Cyanobacteria	J	ribosome binding	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6808297_0	118166.JH976538_gene5042	0.0	1347.0	COG0845@1|root,COG0845@2|Bacteria,1GCFD@1117|Cyanobacteria,1HF90@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6808297_3	118166.JH976538_gene5043	2.07e-202	645.0	28H5N@1|root,2Z7I8@2|Bacteria,1GCEG@1117|Cyanobacteria,1HE1R@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6808297_6	1122947.FR7_4055	4.087e-41	154.0	COG1742@1|root,COG1742@2|Bacteria,1V6YJ@1239|Firmicutes,4H5CN@909932|Negativicutes	909932|Negativicutes	S	UPF0060 membrane protein	-	-	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
LZS2_k127_6808297_2	330214.NIDE0681	2.187e-226	709.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
LZS2_k127_6812319_0	526227.Mesil_2572	3.592e-139	453.0	COG3328@1|root,COG3328@2|Bacteria,1WI20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	COGs COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
LZS2_k127_6812319_6	439235.Dalk_2105	0.0003547	46.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MIMV@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
LZS2_k127_6812319_2	330214.NIDE1387	3.491e-75	261.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114	1.13.11.49	ko:K09162	-	-	-	-	ko00000,ko01000	-	-	-	Chlor_dismutase
LZS2_k127_6812319_1	526227.Mesil_2572	6.609e-104	358.0	COG3328@1|root,COG3328@2|Bacteria,1WI20@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	COGs COG3328 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
LZS2_k127_6812319_3	306281.AJLK01000161_gene239	1.206e-26	115.0	COG0457@1|root,COG0457@2|Bacteria	306281.AJLK01000161_gene239|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6840272_1	330214.NIDE0016	9.496e-83	276.0	COG2514@1|root,COG2514@2|Bacteria	2|Bacteria	S	catechol 2,3-dioxygenase activity	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
LZS2_k127_6840272_2	330214.NIDE0015	1.291e-49	180.0	2CIIF@1|root,315FB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6840272_0	330214.NIDE0014	1.729e-195	614.0	COG0655@1|root,COG2146@1|root,COG0655@2|Bacteria,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	1.2.3.3,1.6.5.2,1.7.1.15	ko:K00158,ko:K00363,ko:K03809,ko:K05710	ko00130,ko00360,ko00620,ko00910,ko01100,ko01110,ko01120,ko01220,map00130,map00360,map00620,map00910,map01100,map01110,map01120,map01220	M00530,M00545	R00207,R00787,R02964,R03643,R03816,R06782,R06783	RC00098,RC00176,RC00819,RC02745	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_red,Rieske,TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
LZS2_k127_6840272_3	335283.Neut_0181	1.883e-28	117.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,374K2@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sterile alpha motif.	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1
LZS2_k127_6842251_3	330214.NIDE2263	2.965e-82	276.0	COG0542@1|root,COG0542@2|Bacteria,3J0AV@40117|Nitrospirae	40117|Nitrospirae	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
LZS2_k127_6842251_1	330214.NIDE2265	3.948e-175	562.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,3J10G@40117|Nitrospirae	40117|Nitrospirae	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
LZS2_k127_6842251_4	330214.NIDE2266	2.434e-58	212.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	yttA	-	2.7.13.3	ko:K07184,ko:K07777,ko:K12065,ko:K13527	ko02020,ko03050,map02020,map03050	M00342,M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03051	3.A.7.11.1	-	-	DUF3102,DUF3450
LZS2_k127_6842251_0	330214.NIDE2267	4.379e-233	729.0	COG2204@1|root,COG2204@2|Bacteria,3J0ZU@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_6849965_6	330214.NIDE0420	2.466e-114	374.0	COG0079@1|root,COG0079@2|Bacteria,3J0XY@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_6849965_1	330214.NIDE0419	6.805e-188	594.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,3J0A9@40117|Nitrospirae	40117|Nitrospirae	E	Chorismate mutase type II	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
LZS2_k127_6849965_2	330214.NIDE0418	2.401e-167	533.0	COG2255@1|root,COG2255@2|Bacteria,3J0AU@40117|Nitrospirae	40117|Nitrospirae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
LZS2_k127_6849965_8	330214.NIDE0416	2.92e-72	248.0	COG0632@1|root,COG0632@2|Bacteria,3J0VA@40117|Nitrospirae	40117|Nitrospirae	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
LZS2_k127_6849965_5	330214.NIDE0415	4.695e-133	428.0	COG0217@1|root,COG0217@2|Bacteria,3J0DM@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
LZS2_k127_6849965_10	330214.NIDE0414	3.702e-64	229.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5,DUF2231,Fn3_assoc,PSCyt1,PSCyt2,PSD1
LZS2_k127_6849965_7	330214.NIDE0413	8.38e-88	296.0	2DQ3Q@1|root,334KX@2|Bacteria	2|Bacteria	S	Proto-chlorophyllide reductase 57 kd subunit	bchB	-	-	-	-	-	-	-	-	-	-	-	PCP_red
LZS2_k127_6849965_15	46234.ANA_C11853	3.293e-13	79.0	2DHJ1@1|root,30005@2|Bacteria,1GFDN@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6849965_14	1122218.KB893653_gene364	2.06e-20	105.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2U93Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	NADH ubiquinone oxidoreductase 41 kD complex I subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6849965_13	1123393.KB891331_gene2951	8.586e-25	111.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1RKGT@1224|Proteobacteria,2W99B@28216|Betaproteobacteria,1KSUY@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA
LZS2_k127_6849965_12	153948.NAL212_2601	6.563e-47	175.0	COG1943@1|root,COG1943@2|Bacteria,1QKQ2@1224|Proteobacteria,2WC8F@28216|Betaproteobacteria,374G1@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
LZS2_k127_6849965_0	330214.NIDE0411	8.205e-307	949.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria	2|Bacteria	P	sulfate adenylyltransferase (ATP) activity	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
LZS2_k127_6849965_3	330214.NIDE0410	1.758e-160	507.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
LZS2_k127_6849965_4	330214.NIDE0409	7.144e-139	451.0	COG0547@1|root,COG0547@2|Bacteria,3J17P@40117|Nitrospirae	40117|Nitrospirae	E	Glycosyl transferase family, a/b domain	-	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
LZS2_k127_6849965_9	330214.NIDE0408	1.062e-65	225.0	COG0175@1|root,COG0175@2|Bacteria	2|Bacteria	EH	sulfate reduction	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
LZS2_k127_6871084_0	330214.NIDE2903	5.24e-303	934.0	COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria	2|Bacteria	G	methylisocitrate lyase activity	pepM	-	2.7.7.74,5.4.2.9	ko:K01841,ko:K07281	ko00440,ko00562,ko01100,ko01120,ko01130,map00440,map00562,map01100,map01120,map01130	-	R00661,R09669	RC00002,RC02792	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,PEP_mutase
LZS2_k127_6871084_3	330214.NIDE2973	6.875e-95	316.0	COG0101@1|root,COG0101@2|Bacteria,3J0PM@40117|Nitrospirae	40117|Nitrospirae	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
LZS2_k127_6871084_2	330214.NIDE2972	6.444e-111	372.0	COG0860@1|root,COG0860@2|Bacteria,3J0MT@40117|Nitrospirae	40117|Nitrospirae	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
LZS2_k127_6871084_4	880072.Desac_2184	1.597e-22	105.0	COG3688@1|root,COG3688@2|Bacteria,1N1NF@1224|Proteobacteria,42UMH@68525|delta/epsilon subdivisions,2WQJ5@28221|Deltaproteobacteria,2MSA5@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
LZS2_k127_6871084_1	330214.NIDE2970	1.192e-125	407.0	COG0084@1|root,COG0084@2|Bacteria,3J0KM@40117|Nitrospirae	40117|Nitrospirae	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
LZS2_k127_6871084_5	228410.NE0294	8.409e-21	93.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2VIUK@28216|Betaproteobacteria,37425@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrom_C,Cytochrome_CBB3,FTR1
LZS2_k127_6899785_5	330214.NIDE0198	3.184e-41	156.0	COG1090@1|root,COG1090@2|Bacteria	2|Bacteria	S	coenzyme binding	yfcH	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
LZS2_k127_6899785_3	330214.NIDE0195	5.819e-126	408.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_6899785_2	330214.NIDE0193	5.144e-176	556.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
LZS2_k127_6899785_0	344747.PM8797T_00899	1.304e-195	623.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
LZS2_k127_6899785_1	330214.NIDE0192	2.814e-178	560.0	COG1262@1|root,COG1262@2|Bacteria,3J14J@40117|Nitrospirae	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
LZS2_k127_6907535_1	330214.NIDE1522	5.761e-94	313.0	COG0637@1|root,COG0637@2|Bacteria,3J15X@40117|Nitrospirae	40117|Nitrospirae	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
LZS2_k127_6907535_2	330214.NIDE1521	2.402e-91	312.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
LZS2_k127_6907535_0	330214.NIDE1520	3.669e-120	392.0	COG1562@1|root,COG1562@2|Bacteria,3J17J@40117|Nitrospirae	40117|Nitrospirae	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
LZS2_k127_6912226_0	330214.NIDE2291	8.083e-139	446.0	COG1157@1|root,COG1157@2|Bacteria,3J0BV@40117|Nitrospirae	40117|Nitrospirae	N	ATP synthase alpha/beta family, beta-barrel domain	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
LZS2_k127_6912226_1	330214.NIDE2293	3.46e-29	126.0	COG3334@1|root,COG3334@2|Bacteria	2|Bacteria	S	PFAM MgtE intracellular	ylxF	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	MgtE_N
LZS2_k127_6935385_1	679926.Mpet_0666	1.766e-68	244.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
LZS2_k127_6935385_0	640081.Dsui_0666	1.178e-205	651.0	COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,2KUVM@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
LZS2_k127_6935385_2	330214.NIDE1763	1.255e-33	132.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HisKA,LpxC,PAS_3,Response_reg
LZS2_k127_6989779_2	485913.Krac_11704	2.065e-45	175.0	COG1985@1|root,COG1985@2|Bacteria,2G97Y@200795|Chloroflexi	200795|Chloroflexi	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
LZS2_k127_6989779_0	706587.Desti_4238	9.565e-155	497.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,42MU3@68525|delta/epsilon subdivisions,2WKTF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
LZS2_k127_6989779_1	1254432.SCE1572_48085	9.876e-96	319.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria	1224|Proteobacteria	H	biosynthesis protein E	pqqE	GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS2_k127_6990894_4	330214.NIDE3747	1.618e-51	185.0	2CIIF@1|root,315FB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6990894_3	330214.NIDE2082	1.332e-71	250.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_5,CHAP,NLPC_P60
LZS2_k127_6990894_0	330214.NIDE3178	1.285e-264	822.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA
LZS2_k127_6990894_1	330214.NIDE3370	6.723e-105	343.0	COG0491@1|root,COG0491@2|Bacteria,3J0VN@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
LZS2_k127_6990894_6	316274.Haur_3491	2.883e-23	107.0	COG0454@1|root,COG0500@1|root,COG0456@2|Bacteria,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Methyltransf_11,Methyltransf_25
LZS2_k127_6990894_8	716544.wcw_0186	2.53e-06	56.0	2DMHT@1|root,32RN3@2|Bacteria,2JHBR@204428|Chlamydiae	204428|Chlamydiae	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
LZS2_k127_6990894_7	330214.NIDE3366	3.307e-08	55.0	COG0180@1|root,COG0180@2|Bacteria,3J0A0@40117|Nitrospirae	40117|Nitrospirae	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
LZS2_k127_6996818_0	330214.NIDE1172	1.661e-156	508.0	COG1805@1|root,COG4402@1|root,COG1805@2|Bacteria,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347,ko:K21163	ko01059,ko01130,map01059,map01130	M00824	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF2330,NQR2_RnfD_RnfE
LZS2_k127_6996818_2	1123059.KB823011_gene1535	3.641e-78	271.0	COG1805@1|root,COG1805@2|Bacteria,1R88C@1224|Proteobacteria,2U32T@28211|Alphaproteobacteria,43Y11@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	Belongs to the NqrB RnfD family	-	-	-	-	-	-	-	-	-	-	-	-	NQR2_RnfD_RnfE
LZS2_k127_6996818_3	375286.mma_3587	1.307e-18	90.0	2EP1T@1|root,315BD@2|Bacteria,1PVCW@1224|Proteobacteria,2WB83@28216|Betaproteobacteria,4757Y@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_6996818_1	330214.NIDE4287	2.526e-102	339.0	COG0205@1|root,COG0406@1|root,COG0205@2|Bacteria,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	His_Phos_1,PFK
LZS2_k127_6998801_5	330214.NIDE0521	1.095e-42	158.0	COG2912@1|root,COG2912@2|Bacteria	2|Bacteria	P	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
LZS2_k127_6998801_1	330214.NIDE0520	1.393e-142	454.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	ycf38	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
LZS2_k127_6998801_0	330214.NIDE0519	4.951e-156	498.0	COG1131@1|root,COG1131@2|Bacteria,3J0JF@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_6998801_3	330214.NIDE0518	5.427e-80	272.0	COG2802@1|root,COG2802@2|Bacteria,3J13Q@40117|Nitrospirae	40117|Nitrospirae	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
LZS2_k127_6998801_2	330214.NIDE0517	2.828e-138	449.0	COG5621@1|root,COG5621@2|Bacteria,3J19I@40117|Nitrospirae	40117|Nitrospirae	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
LZS2_k127_6998801_4	653733.Selin_0317	7.65e-56	198.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
LZS2_k127_7016952_6	330214.NIDE0625	8.977e-05	49.0	28QX7@1|root,2ZDCB@2|Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7016952_3	330214.NIDE0629	6.766e-71	245.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	yneN	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
LZS2_k127_7016952_0	330214.NIDE0623	0.0	1541.0	COG0653@1|root,COG0653@2|Bacteria,3J0E5@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
LZS2_k127_7016952_1	330214.NIDE0616	1.29e-152	492.0	COG1565@1|root,COG1565@2|Bacteria,3J0P0@40117|Nitrospirae	40117|Nitrospirae	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
LZS2_k127_7016952_4	330214.NIDE0615	2.432e-59	207.0	COG0838@1|root,COG0838@2|Bacteria,3J0MS@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
LZS2_k127_7016952_2	330214.NIDE0614	9.423e-78	261.0	COG0377@1|root,COG0377@2|Bacteria,3J11S@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
LZS2_k127_7023228_16	330214.NIDE3217	3.235e-21	101.0	COG1678@1|root,COG1678@2|Bacteria	2|Bacteria	K	ribonucleoside-diphosphate reductase activity	yqgE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
LZS2_k127_7023228_15	1131269.AQVV01000004_gene571	1.386e-25	114.0	COG0790@1|root,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
LZS2_k127_7023228_13	331869.BAL199_20964	5.462e-30	127.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria,4BSDR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
LZS2_k127_7023228_10	330214.NIDE1251	1.194e-42	160.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
LZS2_k127_7023228_4	330214.NIDE1249	9.338e-88	295.0	COG0603@1|root,COG0603@2|Bacteria,3J0NP@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
LZS2_k127_7023228_7	330214.NIDE1248	6.83e-64	224.0	COG1734@1|root,COG1734@2|Bacteria,3J0R1@40117|Nitrospirae	40117|Nitrospirae	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
LZS2_k127_7023228_5	330214.NIDE1247	3.058e-79	269.0	COG0503@1|root,COG0503@2|Bacteria,3J14T@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
LZS2_k127_7023228_2	330214.NIDE1246	5.873e-139	447.0	COG0568@1|root,COG0568@2|Bacteria,3J0E4@40117|Nitrospirae	40117|Nitrospirae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
LZS2_k127_7023228_17	330214.NIDE1245	7.83e-21	94.0	COG1254@1|root,COG1254@2|Bacteria	2|Bacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Acylphosphatase
LZS2_k127_7023228_18	436229.JOEH01000009_gene4564	0.0001411	45.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus	201174|Actinobacteria	K	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
LZS2_k127_7023228_0	330214.NIDE1244	3.01e-167	532.0	COG0686@1|root,COG0686@2|Bacteria	2|Bacteria	E	alanine dehydrogenase activity	ald	GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
LZS2_k127_7023228_12	330214.NIDE1243	1.29e-33	136.0	2CDBX@1|root,2ZUMJ@2|Bacteria,3J1B0@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7023228_9	330214.NIDE1242	1.097e-45	167.0	COG3411@1|root,COG3411@2|Bacteria,3J1DT@40117|Nitrospirae	40117|Nitrospirae	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7023228_11	330214.NIDE1241	2.637e-41	159.0	2ETP6@1|root,33M6W@2|Bacteria,3J18I@40117|Nitrospirae	40117|Nitrospirae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7023228_8	330214.NIDE1240	4.749e-56	196.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
LZS2_k127_7023228_1	323848.Nmul_A0957	4.008e-142	459.0	COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,2VQQ2@28216|Betaproteobacteria,374P4@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Squalene/phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
LZS2_k127_7023228_3	330214.NIDE1236	2.988e-133	430.0	COG0501@1|root,COG0501@2|Bacteria,3J0QG@40117|Nitrospirae	40117|Nitrospirae	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
LZS2_k127_7031296_4	1134912.AJTV01000013_gene558	2.147e-17	85.0	2DQ5D@1|root,334TW@2|Bacteria,1NI32@1224|Proteobacteria,2UMQG@28211|Alphaproteobacteria,370VT@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SMBP
LZS2_k127_7031296_2	330214.NIDE1225	4.769e-99	327.0	COG0299@1|root,COG0299@2|Bacteria,3J0MC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
LZS2_k127_7031296_1	330214.NIDE1224	1.774e-157	502.0	COG0150@1|root,COG0150@2|Bacteria,3J0DR@40117|Nitrospirae	40117|Nitrospirae	F	AIR synthase related protein, N-terminal domain	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
LZS2_k127_7031296_3	330214.NIDE1229	6.81e-46	172.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K03413,ko:K07315	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03021	-	-	-	GGDEF,HATPase_c,HATPase_c_2,HisKA,Response_reg
LZS2_k127_7031296_0	330214.NIDE1223	1.015e-235	736.0	COG2204@1|root,COG2204@2|Bacteria,3J0C2@40117|Nitrospirae	40117|Nitrospirae	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_7031296_5	330214.NIDE1222	3.04e-17	81.0	COG5000@1|root,COG5000@2|Bacteria,3J0B7@40117|Nitrospirae	40117|Nitrospirae	T	GHKL domain	-	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS
LZS2_k127_7047968_1	330214.NIDE2370	1.771e-132	433.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
LZS2_k127_7047968_2	330214.NIDE2369	1.147e-35	138.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	IV02_16530	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
LZS2_k127_7047968_3	234267.Acid_4696	4.781e-05	50.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	rsbV	-	-	ko:K03409,ko:K04749,ko:K07122	ko02010,ko02030,map02010,map02030	M00210	-	-	ko00000,ko00001,ko00002,ko02000,ko02035,ko03021	3.A.1.27.3	-	-	STAS,STAS_2
LZS2_k127_7047968_0	330214.NIDE2367	6.387e-175	553.0	COG2201@1|root,COG2201@2|Bacteria,3J0X3@40117|Nitrospirae	2|Bacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
LZS2_k127_7055214_1	330214.NIDE3782	3.421e-57	203.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,GGDEF
LZS2_k127_7055214_2	330214.NIDE3783	4.492e-35	138.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,GGDEF
LZS2_k127_7055214_4	1397528.Q671_12460	2.35e-12	79.0	COG0589@1|root,COG0589@2|Bacteria,1N7EK@1224|Proteobacteria,1SCRX@1236|Gammaproteobacteria,1XMGK@135619|Oceanospirillales	135619|Oceanospirillales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_7055214_5	1121468.AUBR01000016_gene2293	0.0001143	54.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,42H8S@68295|Thermoanaerobacterales	186801|Clostridia	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
LZS2_k127_7055214_0	330214.NIDE3786	0.0	1227.0	COG0474@1|root,COG0474@2|Bacteria,3J0WH@40117|Nitrospirae	40117|Nitrospirae	P	Cation transporter/ATPase, N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
LZS2_k127_7056830_0	330214.NIDE2927	3.488e-175	559.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,3J0AI@40117|Nitrospirae	40117|Nitrospirae	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
LZS2_k127_7056830_1	330214.NIDE2928	7.773e-114	374.0	2CHNQ@1|root,2Z7KM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7103315_9	330214.NIDE2307	2.219e-40	163.0	COG1419@1|root,COG1419@2|Bacteria,3J162@40117|Nitrospirae	40117|Nitrospirae	N	SRP54-type protein, GTPase domain	-	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
LZS2_k127_7103315_5	330214.NIDE2308	2.842e-99	331.0	COG0455@1|root,COG0455@2|Bacteria,3J0JR@40117|Nitrospirae	40117|Nitrospirae	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31
LZS2_k127_7103315_2	330214.NIDE2309	2.585e-108	355.0	COG1191@1|root,COG1191@2|Bacteria,3J0NW@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-70, region 4	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
LZS2_k127_7103315_4	330214.NIDE2311	1.062e-99	331.0	COG4786@1|root,COG4786@2|Bacteria,3J16I@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar basal body rod FlgEFG protein C-terminal	-	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
LZS2_k127_7103315_1	330214.NIDE2312	4.546e-154	489.0	COG4786@1|root,COG4786@2|Bacteria,3J0IQ@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar basal body rod FlgEFG protein C-terminal	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
LZS2_k127_7103315_8	330214.NIDE2313	6.85e-47	179.0	COG1261@1|root,COG1261@2|Bacteria	2|Bacteria	N	bacterial-type flagellum organization	flgA	-	-	ko:K02279,ko:K02386	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	ChapFlgA
LZS2_k127_7103315_3	330214.NIDE2314	9.557e-100	332.0	COG2063@1|root,COG2063@2|Bacteria,3J16G@40117|Nitrospirae	40117|Nitrospirae	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgH	-	-	ko:K02393	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgH
LZS2_k127_7103315_0	330214.NIDE2315	5.235e-183	578.0	COG1706@1|root,COG1706@2|Bacteria,3J0MB@40117|Nitrospirae	40117|Nitrospirae	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
LZS2_k127_7103315_12	330214.NIDE2316	4.969e-16	83.0	COG3951@1|root,COG3951@2|Bacteria	2|Bacteria	MNO	Flagellar rod assembly protein muramidase FlgJ	flgJ	-	-	ko:K02395,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02035	-	GH23	-	Rod-binding
LZS2_k127_7103315_11	330214.NIDE2317	4.11e-22	99.0	COG2747@1|root,COG2747@2|Bacteria	2|Bacteria	N	bacterial-type flagellum organization	flgM	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009892,GO:0010556,GO:0010605,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0031326,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
LZS2_k127_7103315_6	330214.NIDE2319	1.276e-92	329.0	COG1256@1|root,COG4786@1|root,COG1256@2|Bacteria,COG4786@2|Bacteria,3J0M9@40117|Nitrospirae	40117|Nitrospirae	N	Flagellar basal body rod FlgEFG protein C-terminal	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
LZS2_k127_7103315_13	1121374.KB891586_gene2876	5.715e-12	79.0	COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
LZS2_k127_7103315_10	330214.NIDE2321	2.63e-27	112.0	COG1551@1|root,COG1551@2|Bacteria	2|Bacteria	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563,ko:K13626	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko02035,ko03019	-	-	-	CsrA
LZS2_k127_7103315_7	330214.NIDE2322	6.428e-57	202.0	COG1699@1|root,COG1699@2|Bacteria,3J0V2@40117|Nitrospirae	40117|Nitrospirae	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
LZS2_k127_7104874_2	330214.NIDE0603	3.096e-70	243.0	COG1008@1|root,COG1008@2|Bacteria,3J0EQ@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_7104874_0	330214.NIDE0602	2.831e-205	652.0	COG1007@1|root,COG1007@2|Bacteria,3J0FN@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
LZS2_k127_7104874_1	330214.NIDE0601	5.875e-98	330.0	COG1295@1|root,COG1295@2|Bacteria,3J17V@40117|Nitrospirae	40117|Nitrospirae	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
LZS2_k127_7104874_3	330214.NIDE0600	3.969e-08	56.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3J0VG@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
LZS2_k127_7106765_0	1288494.EBAPG3_12230	1.486e-120	395.0	COG0385@1|root,COG0385@2|Bacteria,1PWDU@1224|Proteobacteria,2WBYI@28216|Betaproteobacteria,3740W@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Sodium Bile acid symporter family	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	-
LZS2_k127_7121550_1	330214.NIDE1873	1.01e-10	65.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
LZS2_k127_7121550_0	880072.Desac_0543	1.425e-33	142.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MS1I@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
LZS2_k127_7132003_4	862908.BMS_0553	3.684e-49	186.0	COG1651@1|root,COG1651@2|Bacteria,1NZPQ@1224|Proteobacteria,42U1T@68525|delta/epsilon subdivisions,2MSXR@213481|Bdellovibrionales,2WQH9@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	PFAM DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
LZS2_k127_7132003_8	1144275.COCOR_00106	2.135e-18	99.0	COG2355@1|root,COG2355@2|Bacteria,1MXA0@1224|Proteobacteria,437UQ@68525|delta/epsilon subdivisions,2X348@28221|Deltaproteobacteria,2YU6N@29|Myxococcales	28221|Deltaproteobacteria	E	Dickkopf N-terminal cysteine-rich region	-	-	-	-	-	-	-	-	-	-	-	-	Dickkopf_N,Peptidase_M19
LZS2_k127_7132003_6	1032480.MLP_33800	5.369e-27	127.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	OapA,OapA_N,Peptidase_M23
LZS2_k127_7132003_9	1242864.D187_003601	2.181e-12	80.0	COG2355@1|root,COG2355@2|Bacteria,1MXA0@1224|Proteobacteria	1224|Proteobacteria	E	COG2355 Zn-dependent dipeptidase microsomal dipeptidase homolog	-	-	-	-	-	-	-	-	-	-	-	-	Dickkopf_N,Peptidase_M19
LZS2_k127_7132003_10	1242864.D187_003601	1.202e-11	78.0	COG2355@1|root,COG2355@2|Bacteria,1MXA0@1224|Proteobacteria	1224|Proteobacteria	E	COG2355 Zn-dependent dipeptidase microsomal dipeptidase homolog	-	-	-	-	-	-	-	-	-	-	-	-	Dickkopf_N,Peptidase_M19
LZS2_k127_7132003_3	290315.Clim_0648	1.173e-51	188.0	299ZY@1|root,2ZX1I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7132003_1	1461693.ATO10_02165	3.333e-64	221.0	COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2UG54@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
LZS2_k127_7132003_5	1395516.PMO01_23485	3.488e-38	148.0	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
LZS2_k127_7132003_7	864051.BurJ1DRAFT_3265	1.725e-22	102.0	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,2VJ48@28216|Betaproteobacteria,1KJCN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
LZS2_k127_7132003_0	180281.CPCC7001_30	3.283e-76	263.0	2ARUG@1|root,31H61@2|Bacteria,1GDA9@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7132003_2	1109445.AGSX01000019_gene1744	1.939e-58	208.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1Z0UK@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
LZS2_k127_7147357_2	330214.NIDE2818	1.05e-178	577.0	2F0JI@1|root,33TN8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7147357_1	330214.NIDE2819	1.238e-196	621.0	COG0014@1|root,COG0014@2|Bacteria,3J0ET@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
LZS2_k127_7147357_8	330214.NIDE2820	1.302e-57	208.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	tklG	-	-	ko:K10927	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	-
LZS2_k127_7147357_10	330214.NIDE2823	1.929e-44	168.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02461,ko:K02662,ko:K02663,ko:K12289	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	PilN
LZS2_k127_7147357_6	330214.NIDE2824	2.61e-66	239.0	COG4972@1|root,COG4972@2|Bacteria	2|Bacteria	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
LZS2_k127_7147357_0	330214.NIDE2825	4.263e-295	913.0	COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	2|Bacteria	NU	Type II/IV secretion system protein	gspE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
LZS2_k127_7147357_4	330214.NIDE2826	2.074e-164	526.0	COG1459@1|root,COG1459@2|Bacteria,3J0HZ@40117|Nitrospirae	40117|Nitrospirae	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
LZS2_k127_7147357_11	330214.NIDE2827	1.038e-32	139.0	COG1388@1|root,COG3170@1|root,COG1388@2|Bacteria,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M23
LZS2_k127_7147357_9	330214.NIDE2828	2.607e-49	178.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	oxpG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
LZS2_k127_7147357_5	330214.NIDE2829	7.375e-76	258.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	pulG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
LZS2_k127_7147357_3	330214.NIDE2830	1.172e-174	560.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria	2|Bacteria	U	Type ii and iii secretion system protein	pulQ	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,STN,Secretin,Secretin_N
LZS2_k127_7151211_7	330214.NIDE0728	4.389e-74	254.0	COG1309@1|root,COG1309@2|Bacteria,3J1CN@40117|Nitrospirae	40117|Nitrospirae	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
LZS2_k127_7151211_3	330214.NIDE0727	4.119e-173	550.0	COG0845@1|root,COG0845@2|Bacteria,3J15F@40117|Nitrospirae	40117|Nitrospirae	M	HlyD family secretion protein	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
LZS2_k127_7151211_0	330214.NIDE0726	0.0	1681.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
LZS2_k127_7151211_14	330214.NIDE0725	3.7e-38	147.0	COG3255@1|root,COG3255@2|Bacteria	2|Bacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
LZS2_k127_7151211_9	330214.NIDE0724	1.058e-58	206.0	COG1586@1|root,COG1586@2|Bacteria	2|Bacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synth
LZS2_k127_7151211_12	330214.NIDE0505	6.155e-47	171.0	COG4446@1|root,COG4446@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
LZS2_k127_7151211_5	330214.NIDE0719	8.736e-147	477.0	28IX1@1|root,2Z8V3@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2914
LZS2_k127_7151211_8	330214.NIDE0715	1.541e-68	239.0	2E469@1|root,32Z27@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7151211_2	330214.NIDE0701	4.241e-174	548.0	COG0142@1|root,COG0142@2|Bacteria,3J0H1@40117|Nitrospirae	40117|Nitrospirae	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
LZS2_k127_7151211_1	330214.NIDE0700	1.349e-178	563.0	COG0451@1|root,COG0451@2|Bacteria,3J0T9@40117|Nitrospirae	40117|Nitrospirae	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
LZS2_k127_7151211_6	330214.NIDE0699	3.001e-116	379.0	COG2324@1|root,COG2324@2|Bacteria,3J195@40117|Nitrospirae	40117|Nitrospirae	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
LZS2_k127_7151211_19	671143.DAMO_1064	2.006e-17	87.0	COG1950@1|root,COG1950@2|Bacteria,2NQ43@2323|unclassified Bacteria	2|Bacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	yvlD	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
LZS2_k127_7151211_10	1121448.DGI_1524	9.434e-55	212.0	COG3291@1|root,COG3291@2|Bacteria,1PHGX@1224|Proteobacteria,437VV@68525|delta/epsilon subdivisions,2X1BB@28221|Deltaproteobacteria,2MEPR@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Metallo-peptidase family M12B Reprolysin-like	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_5
LZS2_k127_7151211_17	671143.DAMO_0216	3.767e-23	101.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	ndoAI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07723	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
LZS2_k127_7151211_13	671143.DAMO_0215	3.202e-43	162.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
LZS2_k127_7191226_5	667632.KB890176_gene4646	0.0006047	49.0	COG1295@1|root,COG1295@2|Bacteria,1R9UY@1224|Proteobacteria,2W2AM@28216|Betaproteobacteria,1K1UA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
LZS2_k127_7191226_3	401526.TcarDRAFT_0435	3.653e-08	58.0	COG5416@1|root,COG5416@2|Bacteria,1VK4W@1239|Firmicutes,4H67X@909932|Negativicutes	909932|Negativicutes	S	Pfam:DUF1049	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
LZS2_k127_7191226_4	240015.ACP_2764	4.517e-05	49.0	COG4980@1|root,COG4980@2|Bacteria,3Y5HP@57723|Acidobacteria,2JJWE@204432|Acidobacteriia	204432|Acidobacteriia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
LZS2_k127_7191226_1	234267.Acid_1271	7.223e-30	132.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
LZS2_k127_7191226_0	330214.NIDE3821	1.466e-84	291.0	COG0836@1|root,COG0836@2|Bacteria	2|Bacteria	M	mannose-1-phosphate guanylyltransferase activity	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
LZS2_k127_7200454_1	595460.RRSWK_03371	4.273e-31	140.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,2J2QP@203682|Planctomycetes	203682|Planctomycetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Reg_prop,Y_Y_Y
LZS2_k127_7200454_0	1007104.SUS17_2328	5.332e-43	177.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg
LZS2_k127_7239202_3	330214.NIDE2055	1.561e-21	95.0	COG0815@1|root,COG0815@2|Bacteria,3J0HA@40117|Nitrospirae	40117|Nitrospirae	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
LZS2_k127_7239202_1	330214.NIDE2054	3.963e-182	575.0	COG1186@1|root,COG1186@2|Bacteria,3J0EX@40117|Nitrospirae	40117|Nitrospirae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
LZS2_k127_7239202_0	330214.NIDE2053	1.339e-274	849.0	COG1190@1|root,COG1190@2|Bacteria,3J0AW@40117|Nitrospirae	40117|Nitrospirae	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
LZS2_k127_7239202_2	330214.NIDE2052	5.005e-136	439.0	COG4591@1|root,COG4591@2|Bacteria,3J0EF@40117|Nitrospirae	40117|Nitrospirae	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
LZS2_k127_726263_9	330214.NIDE3950	2.953e-148	473.0	COG0320@1|root,COG0320@2|Bacteria,3J0IY@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
LZS2_k127_726263_10	330214.NIDE3791	2.709e-109	359.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	ko:K16129	ko01054,map01054	-	-	-	ko00000,ko00001,ko01008	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,Ubie_methyltran
LZS2_k127_726263_3	1267535.KB906767_gene3387	1.539e-253	792.0	COG0033@1|root,COG0033@2|Bacteria,3Y6EH@57723|Acidobacteria,2JM16@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
LZS2_k127_726263_1	330214.NIDE2515	0.0	1150.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2,DUF3971,DUF748
LZS2_k127_726263_5	330214.NIDE2516	4.615e-194	611.0	COG0006@1|root,COG0006@2|Bacteria,3J0R0@40117|Nitrospirae	40117|Nitrospirae	E	Metallopeptidase family M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
LZS2_k127_726263_23	330214.NIDE2519	8.214e-07	53.0	COG1690@1|root,COG1690@2|Bacteria,3J0X0@40117|Nitrospirae	40117|Nitrospirae	S	tRNA-splicing ligase RtcB	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
LZS2_k127_726263_6	330214.NIDE2524	5.278e-190	604.0	COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.6.1.1,1.8.1.4	ko:K00322,ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map00760,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00112,R00209,R01221,R01698,R03815,R07618,R08549	RC00001,RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
LZS2_k127_726263_11	330214.NIDE2525	4.335e-102	341.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
LZS2_k127_726263_15	330214.NIDE2528	3.156e-52	186.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
LZS2_k127_726263_17	330214.NIDE0895	7.118e-37	146.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
LZS2_k127_726263_2	330214.NIDE2536	2.43e-316	977.0	COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae	40117|Nitrospirae	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
LZS2_k127_726263_24	443143.GM18_1663	8.465e-07	58.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_3,DUF4347,HemolysinCabind,Phosphoesterase,VCBS,fn3
LZS2_k127_726263_12	671143.DAMO_1030	5.595e-99	332.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
LZS2_k127_726263_14	330214.NIDE1624	3.994e-65	225.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	cymR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
LZS2_k127_726263_8	330214.NIDE1631	8.045e-160	509.0	COG0752@1|root,COG0752@2|Bacteria,3J0F5@40117|Nitrospirae	40117|Nitrospirae	J	Glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
LZS2_k127_726263_4	330214.NIDE1632	3.58e-220	704.0	COG0751@1|root,COG0751@2|Bacteria,3J0F0@40117|Nitrospirae	40117|Nitrospirae	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
LZS2_k127_726263_0	330214.NIDE1634	0.0	1515.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3J101@40117|Nitrospirae	40117|Nitrospirae	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
LZS2_k127_726263_13	326427.Cagg_2639	2.225e-96	327.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G5SW@200795|Chloroflexi	200795|Chloroflexi	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
LZS2_k127_726263_7	330214.NIDE1636	2.619e-162	521.0	COG4099@1|root,COG4099@2|Bacteria	2|Bacteria	F	phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9
LZS2_k127_7274106_5	330214.NIDE3736	1.569e-108	357.0	COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae	2|Bacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046820,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
LZS2_k127_7274106_4	330214.NIDE3737	5.969e-124	405.0	COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae	2|Bacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	pabC	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
LZS2_k127_7274106_7	330214.NIDE0393	4.254e-54	198.0	COG0741@1|root,COG0741@2|Bacteria,3J19T@40117|Nitrospirae	40117|Nitrospirae	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
LZS2_k127_7274106_1	330214.NIDE3739	2.868e-256	801.0	COG0029@1|root,COG0029@2|Bacteria,3J0DI@40117|Nitrospirae	40117|Nitrospirae	H	FAD binding domain	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
LZS2_k127_7274106_0	330214.NIDE3743	8.529e-271	842.0	COG1132@1|root,COG1132@2|Bacteria,3J0X8@40117|Nitrospirae	40117|Nitrospirae	V	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS2_k127_7274106_6	330214.NIDE0858	3.401e-97	323.0	COG0745@1|root,COG0745@2|Bacteria,3J0JU@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
LZS2_k127_7274106_10	330214.NIDE3611	0.0004395	45.0	COG1723@1|root,COG1723@2|Bacteria	2|Bacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	yagE	-	-	-	-	-	-	-	-	-	-	-	DUF155
LZS2_k127_7274106_3	522306.CAP2UW1_2797	3.708e-198	632.0	COG0598@1|root,COG0598@2|Bacteria,1R7FC@1224|Proteobacteria,2VKBA@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Magnesium transport protein CorA	-	-	-	-	-	-	-	-	-	-	-	-	CorA
LZS2_k127_7274106_2	357808.RoseRS_3717	5.421e-226	718.0	COG0855@1|root,COG0855@2|Bacteria,2G68J@200795|Chloroflexi,374Y0@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
LZS2_k127_7285115_10	316067.Geob_2418	7.276e-34	140.0	COG2197@1|root,COG2197@2|Bacteria,1R4TP@1224|Proteobacteria,42UI0@68525|delta/epsilon subdivisions,2WQIQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Autoinducer binding domain	-	-	-	ko:K20334	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
LZS2_k127_7285115_9	478741.JAFS01000002_gene7	1.013e-46	179.0	COG3916@1|root,COG3916@2|Bacteria	2|Bacteria	QT	Acyl-homoserine-lactone synthase	expI	-	2.3.1.184,2.3.1.228,2.3.1.229	ko:K13060,ko:K13061,ko:K18096,ko:K20248,ko:K20249,ko:K20250	ko00270,ko01100,ko02020,ko02024,ko02025,map00270,map01100,map02020,map02024,map02025	-	R08939,R08940	RC00021,RC00039	ko00000,ko00001,ko01000	-	-	-	Autoind_synth
LZS2_k127_7285115_11	452637.Oter_3651	2.314e-28	124.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	devS	GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K07682	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3
LZS2_k127_7285115_8	1121272.KB903290_gene4696	9.821e-49	183.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4DB3Q@85008|Micromonosporales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
LZS2_k127_7285115_6	1229172.JQFA01000005_gene267	3.668e-68	264.0	COG0642@1|root,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
LZS2_k127_7285115_7	330214.NIDE0586	3.487e-59	212.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
LZS2_k127_7285115_12	1430440.MGMSRv2_1518	2.217e-06	57.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JPVE@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_9,Response_reg
LZS2_k127_7285115_5	330214.NIDE0583	6.224e-85	285.0	COG2862@1|root,COG2862@2|Bacteria	2|Bacteria	S	Uncharacterized protein family, UPF0114	yqhA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03535	-	-	-	-	ko00000,ko02000	2.A.1.14.1	-	-	UPF0114
LZS2_k127_7285115_3	330214.NIDE0804	5.561e-133	444.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	barA	GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700	2.7.13.3	ko:K03407,ko:K07678,ko:K14978	ko02020,ko02025,ko02026,ko02030,ko05111,map02020,map02025,map02026,map02030,map05111	M00475,M00506,M00663	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	DUF2222,HAMP,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
LZS2_k127_7285115_0	330214.NIDE0805	1.866e-306	972.0	COG0784@1|root,COG2198@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,3J0ZF@40117|Nitrospirae	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_7285115_2	330214.NIDE0806	1.565e-156	501.0	COG3287@1|root,COG3287@2|Bacteria	2|Bacteria	M	FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
LZS2_k127_7285115_4	330214.NIDE0807	1.452e-127	424.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,CHASE,EAL,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
LZS2_k127_7285115_1	330214.NIDE0577	4.565e-230	721.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
LZS2_k127_7320615_4	202952.BBLI01000128_gene3991	8.393e-17	90.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3NQKB@468|Moraxellaceae	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,VCBS
LZS2_k127_7320615_2	1157490.EL26_13400	3.011e-36	157.0	COG1361@1|root,COG4932@1|root,COG5184@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1UM5S@1239|Firmicutes,4ITQP@91061|Bacilli,279WZ@186823|Alicyclobacillaceae	91061|Bacilli	DMZ	Cadherin-like beta sandwich domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,SLH
LZS2_k127_7320615_3	1157490.EL26_13400	6.256e-26	119.0	COG1361@1|root,COG4932@1|root,COG5184@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1UM5S@1239|Firmicutes,4ITQP@91061|Bacilli,279WZ@186823|Alicyclobacillaceae	91061|Bacilli	DMZ	Cadherin-like beta sandwich domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,SLH
LZS2_k127_7320615_1	1463885.KL578437_gene9378	6.433e-59	211.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
LZS2_k127_7320615_0	330214.NIDE0166	2.16e-169	541.0	COG1063@1|root,COG4585@1|root,COG1063@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	1.1.1.103,2.7.13.3	ko:K00060,ko:K07777	ko00260,ko02020,map00260,map02020	M00478	R01465	RC00525	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA_3,NAS
LZS2_k127_7320615_5	330214.NIDE0167	4.304e-16	78.0	COG1327@1|root,COG1327@2|Bacteria,3J14C@40117|Nitrospirae	40117|Nitrospirae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
LZS2_k127_7330798_3	330214.NIDE4146	1.001e-115	376.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_7330798_1	330214.NIDE4145	9.126e-229	714.0	COG1004@1|root,COG1004@2|Bacteria,3J0EJ@40117|Nitrospirae	40117|Nitrospirae	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
LZS2_k127_7330798_2	330214.NIDE4143	1.033e-214	678.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Spermine_synth
LZS2_k127_7330798_4	330214.NIDE0145	2.165e-62	223.0	COG1877@1|root,COG1877@2|Bacteria,3J0UY@40117|Nitrospirae	40117|Nitrospirae	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	-	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
LZS2_k127_7330798_0	330214.NIDE0144	0.0	1036.0	COG0380@1|root,COG0380@2|Bacteria,3J109@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
LZS2_k127_7334219_3	330214.NIDE0839	1.364e-321	986.0	COG0029@1|root,COG0029@2|Bacteria,3J0WB@40117|Nitrospirae	40117|Nitrospirae	C	FAD binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
LZS2_k127_7334219_5	330214.NIDE0838	9.024e-141	449.0	COG1152@1|root,COG1152@2|Bacteria,3J11C@40117|Nitrospirae	40117|Nitrospirae	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7334219_1	330214.NIDE0837	0.0	1329.0	COG2838@1|root,COG2838@2|Bacteria	2|Bacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
LZS2_k127_7334219_0	330214.NIDE0836	0.0	1375.0	COG1048@1|root,COG1048@2|Bacteria,3J0E6@40117|Nitrospirae	40117|Nitrospirae	C	Aconitase C-terminal domain	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
LZS2_k127_7334219_2	330214.NIDE0835	0.0	1171.0	COG0074@1|root,COG0372@1|root,COG0074@2|Bacteria,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.8,6.2.1.5	ko:K01902,ko:K15230,ko:K15233	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00352,R00405,R01322,R02404	RC00004,RC00014,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0306	Citrate_synt,CoA_binding,Ligase_CoA,Succ_CoA_lig
LZS2_k127_7334219_4	330214.NIDE0834	2.63e-234	727.0	COG0045@1|root,COG0045@2|Bacteria,3J185@40117|Nitrospirae	40117|Nitrospirae	H	ATP citrate lyase citrate-binding	-	-	2.3.3.8	ko:K15231	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
LZS2_k127_7334219_6	330214.NIDE0833	3.586e-111	365.0	COG0266@1|root,COG0266@2|Bacteria,3J17X@40117|Nitrospirae	40117|Nitrospirae	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
LZS2_k127_7334219_8	330214.NIDE0832	3.399e-39	149.0	COG2453@1|root,COG2453@2|Bacteria	2|Bacteria	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DSPc
LZS2_k127_7334219_11	1137799.GZ78_17515	0.0003189	51.0	2EVXB@1|root,33PAZ@2|Bacteria,1NPNU@1224|Proteobacteria,1SSKE@1236|Gammaproteobacteria,1XPXS@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7334219_10	330214.NIDE0829	7.071e-09	57.0	COG5459@1|root,COG5459@2|Bacteria,3J16W@40117|Nitrospirae	40117|Nitrospirae	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
LZS2_k127_7357455_17	330214.NIDE0483	3.73e-82	277.0	COG4992@1|root,COG4992@2|Bacteria,3J0AB@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
LZS2_k127_7357455_8	330214.NIDE0484	1.233e-142	459.0	COG0078@1|root,COG0078@2|Bacteria,3J0G7@40117|Nitrospirae	40117|Nitrospirae	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
LZS2_k127_7357455_2	330214.NIDE0485	2.595e-220	688.0	COG0137@1|root,COG0137@2|Bacteria,3J0BU@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
LZS2_k127_7357455_4	330214.NIDE0486	6.181e-201	636.0	COG0165@1|root,COG0165@2|Bacteria,3J0EN@40117|Nitrospirae	40117|Nitrospirae	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
LZS2_k127_7357455_3	330214.NIDE0488	6.106e-210	659.0	COG0019@1|root,COG0019@2|Bacteria,3J0CR@40117|Nitrospirae	40117|Nitrospirae	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
LZS2_k127_7357455_9	330214.NIDE0489	1.716e-142	457.0	COG0329@1|root,COG0329@2|Bacteria,3J0CF@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
LZS2_k127_7357455_11	330214.NIDE0490	6.813e-129	416.0	COG0289@1|root,COG0289@2|Bacteria,3J0IJ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
LZS2_k127_7357455_29	330214.NIDE0491	3.11e-11	68.0	COG3350@1|root,COG3350@2|Bacteria	2|Bacteria	T	monooxygenase activity	tmoA	GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494	1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1	ko:K00688,ko:K15760,ko:K16157,ko:K16242,ko:K18223,ko:K22353,ko:K22357	ko00361,ko00362,ko00500,ko00623,ko00625,ko00640,ko00680,ko01100,ko01110,ko01120,ko01200,ko01220,ko02026,ko04217,ko04910,ko04922,ko04931,map00361,map00362,map00500,map00623,map00625,map00640,map00680,map01100,map01110,map01120,map01200,map01220,map02026,map04217,map04910,map04922,map04931	M00174,M00538,M00548	R01142,R02111,R02550,R03560,R03562,R03608,R05444,R05666,R10042,R10043,R10702,R11901	RC00046,RC00173,RC00269,RC00490,RC01383,RC03249	ko00000,ko00001,ko00002,ko01000	-	GT35	-	Phenol_Hydrox,YHS
LZS2_k127_7357455_12	330214.NIDE0493	4.608e-116	376.0	COG0176@1|root,COG0176@2|Bacteria,3J0YY@40117|Nitrospirae	40117|Nitrospirae	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
LZS2_k127_7357455_13	330214.NIDE0494	5.015e-114	370.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
LZS2_k127_7357455_6	330214.NIDE0495	6.883e-158	504.0	COG0741@1|root,COG0741@2|Bacteria,3J0J4@40117|Nitrospirae	2|Bacteria	M	Lysin motif	mltD_2	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
LZS2_k127_7357455_7	330214.NIDE0496	7.694e-144	469.0	COG2379@1|root,COG2379@2|Bacteria,3J16T@40117|Nitrospirae	40117|Nitrospirae	H	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
LZS2_k127_7357455_0	330214.NIDE0497	1.986e-284	898.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,3J0QY@40117|Nitrospirae	40117|Nitrospirae	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
LZS2_k127_7357455_5	330214.NIDE0498	3.339e-169	544.0	COG1322@1|root,COG1322@2|Bacteria,3J15T@40117|Nitrospirae	40117|Nitrospirae	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
LZS2_k127_7357455_21	330214.NIDE0499	6.297e-49	181.0	COG4696@1|root,COG4696@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	XK27_03185	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	Acetyltransf_3,Hydrolase_3,PRA-PH
LZS2_k127_7357455_14	330214.NIDE0501	2.414e-108	359.0	COG0414@1|root,COG0414@2|Bacteria,3J0KR@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
LZS2_k127_7357455_18	330214.NIDE0502	5.162e-76	259.0	COG0801@1|root,COG0801@2|Bacteria,3J19N@40117|Nitrospirae	40117|Nitrospirae	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
LZS2_k127_7357455_1	330214.NIDE0503	9.302e-242	748.0	COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_7357455_23	1333998.M2A_2723	6.632e-41	159.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2TU60@28211|Alphaproteobacteria,4BR27@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
LZS2_k127_7357455_15	330214.NIDE0511	1.158e-97	324.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
LZS2_k127_7357455_10	330214.NIDE0516	4.887e-140	453.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	hcf136	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
LZS2_k127_7357455_25	396588.Tgr7_2087	4.872e-37	143.0	COG5499@1|root,COG5499@2|Bacteria,1MZHS@1224|Proteobacteria,1S4IJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcription regulator containing HTH domain	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	HTH_3,Peptidase_M78
LZS2_k127_7357455_27	945713.IALB_0330	9.477e-34	132.0	COG4680@1|root,COG4680@2|Bacteria	2|Bacteria	K	protein conserved in bacteria	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
LZS2_k127_7357455_30	472759.Nhal_0242	4.545e-05	51.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31,MqsA_antitoxin
LZS2_k127_7389173_1	330214.NIDE2408	1.405e-111	368.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	ko:K07011,ko:K16706	-	-	-	-	ko00000	-	-	-	GNVR,Wzz
LZS2_k127_7389173_2	330214.NIDE2409	1.005e-102	346.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	epsB	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA
LZS2_k127_7389173_0	330214.NIDE2411	5.343e-121	403.0	COG0457@1|root,COG3267@1|root,COG0457@2|Bacteria,COG3267@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	exeA	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,OmpA
LZS2_k127_7431311_3	316058.RPB_1968	9.157e-74	252.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2TR8A@28211|Alphaproteobacteria,3K275@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
LZS2_k127_7431311_8	643648.Slip_0798	4.518e-06	54.0	COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,42KWN@68298|Syntrophomonadaceae	186801|Clostridia	T	PFAM low molecular weight phosphotyrosine protein phosphatase	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
LZS2_k127_7431311_6	330214.NIDE3707	1.16e-09	61.0	COG0394@1|root,COG0394@2|Bacteria,3J1AU@40117|Nitrospirae	40117|Nitrospirae	T	Low molecular weight phosphatase family	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
LZS2_k127_7431311_7	1235990.HHS_07070	8.43e-09	61.0	COG1067@1|root,COG1067@2|Bacteria,2NP29@2323|unclassified Bacteria	2|Bacteria	O	peptidase S16	ycbZ	-	-	ko:K04770	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
LZS2_k127_7431311_0	330214.NIDE3773	0.0	1099.0	COG1067@1|root,COG1067@2|Bacteria,3J0X2@40117|Nitrospirae	40117|Nitrospirae	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
LZS2_k127_7431311_2	330214.NIDE3770	2.511e-157	503.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
LZS2_k127_7431311_4	330214.NIDE3769	5.207e-64	224.0	COG0529@1|root,COG0529@2|Bacteria	2|Bacteria	P	adenylylsulfate kinase activity	cysC	-	2.7.1.25,2.7.7.4	ko:K00860,ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
LZS2_k127_7431311_1	269799.Gmet_0994	7.896e-239	781.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,43SYH@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM SNF2-related protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
LZS2_k127_7431311_5	1210884.HG799469_gene14135	4.138e-50	197.0	COG3852@1|root,COG4585@1|root,COG3852@2|Bacteria,COG4585@2|Bacteria,2J0U8@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3
LZS2_k127_743955_1	1123060.JONP01000083_gene207	1.562e-106	359.0	COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,2U60M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
LZS2_k127_743955_5	1120956.JHZK01000057_gene1843	1.374e-21	98.0	COG2963@1|root,COG2963@2|Bacteria,1N75X@1224|Proteobacteria,2UIVT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28
LZS2_k127_743955_3	7739.XP_002602044.1	8.935e-37	161.0	COG3914@1|root,KOG4626@2759|Eukaryota,39NJE@33154|Opisthokonta,3CQ3M@33208|Metazoa,3E694@33213|Bilateria,48RPC@7711|Chordata	2759|Eukaryota	GOT	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF294,TPR_10,TPR_12,TPR_16,TPR_7,TPR_8
LZS2_k127_743955_4	330214.NIDE2813	1.112e-22	98.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	yuxK	-	-	-	-	-	-	-	-	-	-	-	DUF393
LZS2_k127_743955_6	1131269.AQVV01000004_gene576	3.745e-21	106.0	COG0790@1|root,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
LZS2_k127_743955_0	873513.HMPREF6485_2887	4.467e-115	387.0	COG3385@1|root,COG3385@2|Bacteria,4NXT2@976|Bacteroidetes,2FRVS@200643|Bacteroidia	976|Bacteroidetes	L	hmm pf01609	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
LZS2_k127_743955_2	330214.NIDE2813	8.473e-58	205.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	yuxK	-	-	-	-	-	-	-	-	-	-	-	DUF393
LZS2_k127_7440185_3	330214.NIDE2930	3.773e-60	211.0	COG1230@1|root,COG1230@2|Bacteria,3J11Z@40117|Nitrospirae	40117|Nitrospirae	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
LZS2_k127_7440185_6	1266908.AQPB01000054_gene1689	1.255e-39	151.0	COG2445@1|root,COG2445@2|Bacteria,1QYJX@1224|Proteobacteria,1T4PR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Nucleotidyltransferase substrate binding protein like	-	-	-	-	-	-	-	-	-	-	-	-	NTase_sub_bind
LZS2_k127_7440185_8	330214.NIDE2930	5.948e-10	63.0	COG1230@1|root,COG1230@2|Bacteria,3J11Z@40117|Nitrospirae	40117|Nitrospirae	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
LZS2_k127_7440185_2	768670.Calni_0521	1.552e-128	424.0	COG1055@1|root,COG1055@2|Bacteria	2|Bacteria	P	arsenite transmembrane transporter activity	arsB	-	-	-	-	-	-	-	-	-	-	-	CitMHS
LZS2_k127_7440185_4	330214.NIDE3087	2.292e-56	206.0	COG3108@1|root,COG3108@2|Bacteria	2|Bacteria	S	Peptidase M15	ycbK	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Peptidase_M15_2,Peptidase_M15_3
LZS2_k127_7440185_5	330214.NIDE1763	8.513e-53	188.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HisKA,LpxC,PAS_3,Response_reg
LZS2_k127_7440185_0	330214.NIDE1759	7.394e-152	487.0	COG0778@1|root,COG0778@2|Bacteria,3J0XZ@40117|Nitrospirae	40117|Nitrospirae	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7443742_15	204669.Acid345_4081	5.695e-13	70.0	COG2197@1|root,COG2197@2|Bacteria,3Y8R3@57723|Acidobacteria,2JNDY@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
LZS2_k127_7443742_17	1318628.MARLIPOL_02265	1.144e-10	71.0	2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
LZS2_k127_7443742_2	1198114.AciX9_2007	1.141e-155	500.0	COG2826@1|root,COG2826@2|Bacteria,3Y896@57723|Acidobacteria,2JN59@204432|Acidobacteriia	204432|Acidobacteriia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
LZS2_k127_7443742_16	398512.JQKC01000051_gene2631	6.1e-12	68.0	COG4644@1|root,COG4644@2|Bacteria,1UZ13@1239|Firmicutes,24FFD@186801|Clostridia,3WGJ3@541000|Ruminococcaceae	186801|Clostridia	L	Tn3 transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
LZS2_k127_7443742_3	330214.NIDE3081	9.937e-137	436.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
LZS2_k127_7443742_1	330214.NIDE3079	4.755e-156	503.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,3J1AS@40117|Nitrospirae	40117|Nitrospirae	S	Competence-damaged protein	-	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
LZS2_k127_7443742_6	330214.NIDE3078	4.377e-61	217.0	COG1514@1|root,COG1514@2|Bacteria,3J1B8@40117|Nitrospirae	40117|Nitrospirae	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
LZS2_k127_7443742_14	5061.CADANGAP00003254	2.799e-18	92.0	COG0666@1|root,KOG4177@2759|Eukaryota,39VF6@33154|Opisthokonta,3NZ3K@4751|Fungi,3QNR2@4890|Ascomycota	4751|Fungi	S	HET domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,HET
LZS2_k127_7443742_4	1122604.JONR01000036_gene3792	1.163e-134	439.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,1X3K9@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
LZS2_k127_7443742_9	330214.NIDE1372	6.566e-45	164.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
LZS2_k127_7443742_7	330214.NIDE1373	7.842e-49	178.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	relF	GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141	2.3.1.15	ko:K08591,ko:K19159	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko02048	-	-	-	PhdYeFM_antitox
LZS2_k127_7443742_11	102125.Xen7305DRAFT_00033350	1.968e-31	128.0	COG4634@1|root,COG4634@2|Bacteria,1GJHD@1117|Cyanobacteria,3VMY5@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7443742_12	221288.JH992901_gene5377	1.272e-25	107.0	COG2442@1|root,COG2442@2|Bacteria,1G9UJ@1117|Cyanobacteria,1JM6U@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
LZS2_k127_7443742_0	330214.NIDE1705	4.559e-183	577.0	COG0468@1|root,COG0468@2|Bacteria,3J0C1@40117|Nitrospirae	40117|Nitrospirae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
LZS2_k127_7470154_2	234267.Acid_1204	6.507e-36	141.0	COG1174@1|root,COG1174@2|Bacteria	2|Bacteria	P	glycine betaine transport	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
LZS2_k127_7470154_1	497965.Cyan7822_5512	4.603e-93	312.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,3KHZZ@43988|Cyanothece	1117|Cyanobacteria	P	PFAM ABC transporter related	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
LZS2_k127_7470154_0	525897.Dbac_1184	5.613e-176	565.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1MVRR@1224|Proteobacteria,42NSC@68525|delta/epsilon subdivisions,2WMAX@28221|Deltaproteobacteria,2MBD3@213115|Desulfovibrionales	28221|Deltaproteobacteria	CE	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
LZS2_k127_7470154_3	408672.NBCG_02704	3.827e-20	91.0	COG5637@1|root,COG5637@2|Bacteria,2GMK7@201174|Actinobacteria,4DQWY@85009|Propionibacteriales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
LZS2_k127_7478695_1	1178537.BA1_05607	3.133e-52	199.0	COG2516@1|root,COG2516@2|Bacteria,1UI8Q@1239|Firmicutes,4HV1D@91061|Bacilli,1ZJTY@1386|Bacillus	91061|Bacilli	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
LZS2_k127_7478695_0	935261.JAGL01000008_gene2301	1.142e-126	411.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,43HWH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
LZS2_k127_7478695_2	1121918.ARWE01000001_gene1747	2.706e-28	116.0	COG2963@1|root,COG2963@2|Bacteria,1N8W3@1224|Proteobacteria,42VV3@68525|delta/epsilon subdivisions,2WSHS@28221|Deltaproteobacteria,43V9G@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_Tnp_1
LZS2_k127_7493913_0	247490.KSU1_B0323	0.0	1036.0	COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
LZS2_k127_7493913_2	264732.Moth_1809	4.454e-210	674.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,42FTG@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459
LZS2_k127_7493913_5	1123376.AUIU01000018_gene50	8.829e-89	302.0	COG0668@1|root,COG0668@2|Bacteria,3J0YK@40117|Nitrospirae	40117|Nitrospirae	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
LZS2_k127_7493913_4	330214.NIDE0473	1.169e-147	477.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
LZS2_k127_7493913_3	330214.NIDE0474	4.089e-154	495.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
LZS2_k127_7493913_1	575540.Isop_3152	2.37e-312	972.0	COG0296@1|root,COG0296@2|Bacteria,2IXS1@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
LZS2_k127_7493913_6	269799.Gmet_1154	3.508e-42	169.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42N2T@68525|delta/epsilon subdivisions,2WMYV@28221|Deltaproteobacteria,43SP8@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
LZS2_k127_7493913_7	861299.J421_2878	3.42e-06	54.0	COG1295@1|root,COG1295@2|Bacteria,1ZTHX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
LZS2_k127_7517828_1	857087.Metme_0657	2.139e-128	426.0	COG1404@1|root,COG1404@2|Bacteria,1NR78@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7517828_11	1267533.KB906742_gene788	1.45e-12	78.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7517828_2	1125863.JAFN01000001_gene3206	8.716e-87	304.0	COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
LZS2_k127_7517828_9	1198452.Jab_1c20520	1.387e-14	79.0	COG5563@1|root,COG5563@2|Bacteria,1NNVR@1224|Proteobacteria,2WG1K@28216|Betaproteobacteria,477VK@75682|Oxalobacteraceae	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3466,HemolysinCabind,VPEP
LZS2_k127_7517828_3	1162668.LFE_1357	8.624e-49	181.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS2_k127_7517828_5	1162668.LFE_1358	7.301e-22	96.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
LZS2_k127_7517828_10	32057.KB217478_gene5311	1.956e-14	74.0	COG3668@1|root,COG3668@2|Bacteria,1G8WD@1117|Cyanobacteria,1HNXJ@1161|Nostocales	1117|Cyanobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
LZS2_k127_7517828_0	857087.Metme_2760	1.342e-191	610.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,1T2R5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7517828_7	330214.NIDE2437	4.333e-21	108.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE2437|-	T	phosphorelay signal transduction system	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	-
LZS2_k127_7517828_12	1162668.LFE_1401	1.445e-10	65.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K08364	-	-	-	-	ko00000,ko02000	1.A.72.1	-	-	HMA
LZS2_k127_7517828_8	330214.NIDE0636	1.707e-15	79.0	COG2452@1|root,COG2452@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2281,HTH_17
LZS2_k127_7517828_6	330214.NIDE3710	1.119e-21	97.0	COG0640@1|root,COG0640@2|Bacteria,3J1BW@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
LZS2_k127_7517828_4	330214.NIDE0676	1.991e-43	161.0	COG3065@1|root,COG3065@2|Bacteria,3J1BB@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07285	-	-	-	-	ko00000	-	-	-	Slp
LZS2_k127_755705_0	1267533.KB906735_gene4635	1.536e-250	785.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
LZS2_k127_755705_1	261292.Nit79A3_1326	4.254e-121	394.0	COG1573@1|root,COG1573@2|Bacteria,1R207@1224|Proteobacteria,2WBUV@28216|Betaproteobacteria,373UC@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
LZS2_k127_755705_6	331869.BAL199_21359	1.181e-09	61.0	2CKQA@1|root,33F1D@2|Bacteria,1NNBI@1224|Proteobacteria,2UMHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_755705_4	1128427.KB904821_gene2774	4.805e-16	82.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
LZS2_k127_755705_3	357808.RoseRS_0548	2.83e-35	138.0	COG2361@1|root,COG2361@2|Bacteria,2G8W4@200795|Chloroflexi	2|Bacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
LZS2_k127_755705_5	331869.BAL199_21359	6.578e-11	66.0	2CKQA@1|root,33F1D@2|Bacteria,1NNBI@1224|Proteobacteria,2UMHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_755705_2	1242864.D187_007397	1.985e-40	155.0	2E0G4@1|root,32W27@2|Bacteria,1N463@1224|Proteobacteria,42VTW@68525|delta/epsilon subdivisions,2WSDZ@28221|Deltaproteobacteria,2YXTB@29|Myxococcales	28221|Deltaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
LZS2_k127_7559843_6	330214.NIDE4146	3.35e-12	67.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_7559843_4	330214.NIDE4147	2.644e-111	364.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_7559843_1	330214.NIDE4148	8.583e-152	488.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_7559843_2	330214.NIDE4149	1.498e-128	420.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_7559843_0	330214.NIDE4150	2.499e-226	709.0	COG1413@1|root,COG1413@2|Bacteria,3J1E2@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
LZS2_k127_7559843_3	330214.NIDE4152	4.573e-122	398.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE,Phosphodiest
LZS2_k127_7573450_8	330214.NIDE2050	2.836e-58	205.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	TraF_2
LZS2_k127_7573450_7	330214.NIDE2049	5.866e-69	239.0	2FJ9R@1|root,34AZR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7573450_4	330214.NIDE2047	9.22e-110	360.0	COG0159@1|root,COG0159@2|Bacteria,3J0ME@40117|Nitrospirae	40117|Nitrospirae	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
LZS2_k127_7573450_1	330214.NIDE2046	3.536e-215	672.0	COG0133@1|root,COG0133@2|Bacteria,3J0E1@40117|Nitrospirae	40117|Nitrospirae	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
LZS2_k127_7573450_6	330214.NIDE2045	2.974e-90	302.0	COG0135@1|root,COG0135@2|Bacteria,3J0SA@40117|Nitrospirae	40117|Nitrospirae	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
LZS2_k127_7573450_3	330214.NIDE2043	5.857e-121	393.0	COG0134@1|root,COG0134@2|Bacteria,3J0NT@40117|Nitrospirae	40117|Nitrospirae	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
LZS2_k127_7573450_2	330214.NIDE2042	1.092e-153	491.0	COG0547@1|root,COG0547@2|Bacteria,3J0HE@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
LZS2_k127_7573450_5	330214.NIDE2041	5.585e-101	331.0	COG0512@1|root,COG0512@2|Bacteria,3J0H8@40117|Nitrospirae	40117|Nitrospirae	EH	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
LZS2_k127_7573450_0	330214.NIDE2040	1.682e-250	780.0	COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae	40117|Nitrospirae	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
LZS2_k127_7573450_9	330214.NIDE2039	6.869e-42	162.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
LZS2_k127_7796905_1	330214.NIDE1376	1.018e-316	984.0	COG1391@1|root,COG2844@1|root,COG1391@2|Bacteria,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89	ko:K00003,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020	M00017,M00018	R00243,R01773,R01775	RC00006,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	GlnD_UR_UTase,GlnE,HD
LZS2_k127_7796905_2	330214.NIDE1377	7.139e-205	652.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
LZS2_k127_7796905_0	330214.NIDE1378	7.961e-319	980.0	COG0459@1|root,COG0459@2|Bacteria,3J0DA@40117|Nitrospirae	40117|Nitrospirae	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
LZS2_k127_7796905_4	330214.NIDE1379	1.91e-48	174.0	COG0234@1|root,COG0234@2|Bacteria,3J0RF@40117|Nitrospirae	40117|Nitrospirae	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
LZS2_k127_7796905_3	330214.NIDE1381	7.506e-144	458.0	COG0568@1|root,COG0568@2|Bacteria	2|Bacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
LZS2_k127_7834621_9	589865.DaAHT2_1068	9.973e-07	51.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
LZS2_k127_7834621_6	96561.Dole_0659	9.53e-24	101.0	COG3514@1|root,COG3514@2|Bacteria,1PWSE@1224|Proteobacteria,43A9S@68525|delta/epsilon subdivisions,2WTC0@28221|Deltaproteobacteria,2MP7T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7834621_4	96561.Dole_0658	1.256e-35	138.0	COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,42VMA@68525|delta/epsilon subdivisions,2WS3K@28221|Deltaproteobacteria,2MKVT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
LZS2_k127_7834621_7	589865.DaAHT2_1068	4.63e-23	100.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
LZS2_k127_7834621_8	1249997.JHZW01000002_gene1766	1.068e-17	91.0	COG4333@1|root,COG4333@2|Bacteria,4NW3C@976|Bacteroidetes,1I69D@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1643)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1643
LZS2_k127_7834621_5	1173029.JH980292_gene2841	2.719e-28	118.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
LZS2_k127_7834621_1	330214.NIDE1189	9.562e-96	318.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
LZS2_k127_7834621_3	330214.NIDE1188	1.956e-63	222.0	COG2258@1|root,COG2258@2|Bacteria	2|Bacteria	C	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
LZS2_k127_7834621_2	330214.NIDE1187	1.256e-75	264.0	COG2264@1|root,COG2264@2|Bacteria,3J1B7@40117|Nitrospirae	40117|Nitrospirae	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
LZS2_k127_7834621_0	330214.NIDE1186	8.575e-173	559.0	COG0249@1|root,COG0249@2|Bacteria	2|Bacteria	L	mismatched DNA binding	mutS1	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_III,MutS_V
LZS2_k127_7843507_0	330214.NIDE0872	1.303e-203	647.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,3J12F@40117|Nitrospirae	40117|Nitrospirae	P	TrkA-N domain	-	-	-	ko:K03455,ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6,2.A.37	-	-	Ion_trans_2,TrkA_C,TrkA_N
LZS2_k127_7843507_1	330214.NIDE0045	3.126e-103	340.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
LZS2_k127_7843507_2	330214.NIDE0016	1.711e-80	273.0	COG2514@1|root,COG2514@2|Bacteria	2|Bacteria	S	catechol 2,3-dioxygenase activity	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
LZS2_k127_7843507_3	330214.NIDE0015	3.628e-50	183.0	2CIIF@1|root,315FB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7861731_2	330214.NIDE3639	6.562e-62	216.0	COG1061@1|root,COG1061@2|Bacteria	2|Bacteria	L	Type III restriction enzyme res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
LZS2_k127_7861731_1	330214.NIDE2074	2.622e-221	688.0	COG1697@1|root,COG1697@2|Bacteria	2|Bacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DUF2220,DUF3322,TP6A_N
LZS2_k127_7861731_0	330214.NIDE2073	0.0	1030.0	COG1389@1|root,COG1389@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
LZS2_k127_7870113_8	671143.DAMO_1538	1.193e-66	234.0	COG0668@1|root,COG0668@2|Bacteria,2NQ6B@2323|unclassified Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
LZS2_k127_7870113_6	671143.DAMO_1539	2.11e-108	365.0	COG0463@1|root,COG0463@2|Bacteria,2NQD9@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
LZS2_k127_7870113_5	909663.KI867151_gene3002	8.155e-134	437.0	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
LZS2_k127_7870113_1	1128421.JAGA01000004_gene2674	7.734e-262	816.0	COG0366@1|root,COG0366@2|Bacteria,2NQND@2323|unclassified Bacteria	2|Bacteria	G	Maltogenic Amylase, C-terminal domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
LZS2_k127_7870113_9	891968.Anamo_1585	3.041e-32	136.0	COG0438@1|root,COG0438@2|Bacteria,3TC5G@508458|Synergistetes	508458|Synergistetes	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7870113_2	1038860.AXAP01000029_gene688	6.539e-242	761.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,3JRQ3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
LZS2_k127_7870113_7	479434.Sthe_1092	6.081e-78	282.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia	189775|Thermomicrobia	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
LZS2_k127_7870113_3	1380394.JADL01000005_gene5439	5.794e-236	748.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2TVJ1@28211|Alphaproteobacteria,2JQZS@204441|Rhodospirillales	204441|Rhodospirillales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
LZS2_k127_7870113_0	316067.Geob_1217	2.509e-311	981.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TIGRFAM Malto-oligosyltrehalose synthase	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
LZS2_k127_7870113_4	1288494.EBAPG3_11200	3.894e-144	468.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,372V3@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
LZS2_k127_7870113_11	1157708.KB907450_gene6310	3.984e-11	72.0	COG1309@1|root,COG1309@2|Bacteria,1MZEP@1224|Proteobacteria,2VRMH@28216|Betaproteobacteria,4AGG8@80864|Comamonadaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
LZS2_k127_7870113_10	177437.HRM2_03300	8.76e-17	83.0	COG0296@1|root,COG0296@2|Bacteria,1NIZI@1224|Proteobacteria,42WYM@68525|delta/epsilon subdivisions,2WSNX@28221|Deltaproteobacteria,2MMER@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Glycogen recognition site of AMP-activated protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM
LZS2_k127_7871118_0	330214.NIDE2199	9.179e-206	654.0	COG2206@1|root,COG2206@2|Bacteria,3J14V@40117|Nitrospirae	40117|Nitrospirae	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD
LZS2_k127_7871118_1	330214.NIDE2200	1.351e-195	627.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,PT-HINT,Sulfatase
LZS2_k127_7871118_3	330214.NIDE2201	1.413e-69	242.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
LZS2_k127_7871118_4	330214.NIDE2202	5.176e-33	132.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
LZS2_k127_7871118_2	330214.NIDE2203	4.135e-72	244.0	COG0364@1|root,COG0364@2|Bacteria,3J0XD@40117|Nitrospirae	40117|Nitrospirae	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
LZS2_k127_7890412_4	330214.NIDE4122	8.884e-10	59.0	COG0249@1|root,COG0249@2|Bacteria,3J0CE@40117|Nitrospirae	40117|Nitrospirae	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
LZS2_k127_7890412_0	330214.NIDE4126	4.25e-170	543.0	COG0612@1|root,COG0612@2|Bacteria,3J0GS@40117|Nitrospirae	40117|Nitrospirae	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
LZS2_k127_7890412_3	330214.NIDE4127	8.626e-58	203.0	COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae	40117|Nitrospirae	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
LZS2_k127_7897928_11	935261.JAGL01000068_gene3929	1.463e-58	226.0	COG1961@1|root,COG1961@2|Bacteria,1MV0C@1224|Proteobacteria,2TTJT@28211|Alphaproteobacteria,43I55@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
LZS2_k127_7897928_13	323848.Nmul_A1741	1.112e-33	141.0	28M95@1|root,2ZAN4@2|Bacteria,1R588@1224|Proteobacteria,2W0AN@28216|Betaproteobacteria,372YQ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
LZS2_k127_7897928_0	477974.Daud_0199	0.0	1758.0	COG3587@1|root,COG3587@2|Bacteria	2|Bacteria	L	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
LZS2_k127_7897928_1	933262.AXAM01000001_gene377	0.0	1340.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,42Q2X@68525|delta/epsilon subdivisions,2WNQB@28221|Deltaproteobacteria,2MMA7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
LZS2_k127_7897928_2	981336.F944_02922	0.0	1133.0	COG1431@1|root,COG1431@2|Bacteria,1R5TD@1224|Proteobacteria,1S178@1236|Gammaproteobacteria,3NQ1N@468|Moraxellaceae	1236|Gammaproteobacteria	J	Piwi	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
LZS2_k127_7897928_3	1121918.ARWE01000001_gene2681	1.004e-314	976.0	COG0210@1|root,COG0210@2|Bacteria,1MWW6@1224|Proteobacteria,42PC0@68525|delta/epsilon subdivisions,2WM52@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
LZS2_k127_7897928_7	324057.Pjdr2_4758	6.978e-170	570.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	-	ko:K02057,ko:K10110,ko:K19171	ko02010,map02010	M00194,M00221	-	-	ko00000,ko00001,ko00002,ko02000,ko02048	3.A.1.1.1,3.A.1.1.22,3.A.1.2	-	-	AAA_11,AAA_12,AAA_15,BPD_transp_2,MukB
LZS2_k127_7897928_17	1121918.ARWE01000001_gene2681	1.038e-15	78.0	COG0210@1|root,COG0210@2|Bacteria,1MWW6@1224|Proteobacteria,42PC0@68525|delta/epsilon subdivisions,2WM52@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
LZS2_k127_7897928_5	491916.RHECIAT_PC0000109	6.054e-238	746.0	COG2865@1|root,COG2865@2|Bacteria,1MXG1@1224|Proteobacteria,2U2ED@28211|Alphaproteobacteria,4BHP1@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
LZS2_k127_7897928_18	251221.35213305	0.0005953	46.0	COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1G2NF@1117|Cyanobacteria	1117|Cyanobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DUF1998,Helicase_C
LZS2_k127_7897928_6	1242864.D187_000498	1.564e-212	715.0	COG5635@1|root,COG5635@2|Bacteria,1N22Y@1224|Proteobacteria	1224|Proteobacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA
LZS2_k127_7897928_14	880072.Desac_0995	5.217e-31	127.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
LZS2_k127_7897928_8	880072.Desac_0493	4.178e-148	482.0	COG0457@1|root,COG0491@1|root,COG0457@2|Bacteria,COG0491@2|Bacteria,1NX55@1224|Proteobacteria,430IJ@68525|delta/epsilon subdivisions,2WVK3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
LZS2_k127_7897928_12	1121468.AUBR01000012_gene2604	1.223e-52	190.0	2F79F@1|root,33ZQP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7897928_15	880072.Desac_0497	8.324e-31	126.0	2FJKA@1|root,34B9P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7897928_10	880072.Desac_0498	3.384e-82	276.0	2F0YS@1|root,33U0E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7897928_4	880072.Desac_0499	1.693e-246	766.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,42NP0@68525|delta/epsilon subdivisions,2WVG4@28221|Deltaproteobacteria,2MRQ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
LZS2_k127_7897928_9	880072.Desac_0500	2.815e-95	313.0	COG1804@1|root,COG1804@2|Bacteria,1NWFC@1224|Proteobacteria,4300F@68525|delta/epsilon subdivisions,2X2A6@28221|Deltaproteobacteria,2MRS4@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
LZS2_k127_7904448_2	272123.Anacy_5443	2.077e-76	263.0	COG3485@1|root,COG3485@2|Bacteria,1G538@1117|Cyanobacteria,1HQQI@1161|Nostocales	1117|Cyanobacteria	Q	COGs COG3485 Protocatechuate 3 4-dioxygenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Dioxygenase_C
LZS2_k127_7904448_1	330214.NIDE1696	2.981e-99	330.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
LZS2_k127_7914793_0	330214.NIDE3699	9.966e-185	584.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Methyltransf_31,Radical_SAM
LZS2_k127_7914793_2	330214.NIDE3700	7.008e-47	171.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
LZS2_k127_7914793_1	330214.NIDE3701	1.14e-58	205.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
LZS2_k127_7918120_16	330214.NIDE4351	4.654e-45	169.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	suhB2	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4170,Inositol_P
LZS2_k127_7918120_4	237368.SCABRO_02415	1.219e-125	411.0	COG0598@1|root,COG0598@2|Bacteria,2IX61@203682|Planctomycetes	203682|Planctomycetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
LZS2_k127_7918120_6	330214.NIDE4348	5.916e-106	349.0	COG0066@1|root,COG0066@2|Bacteria,3J10U@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
LZS2_k127_7918120_1	330214.NIDE4347	6.173e-259	805.0	COG0065@1|root,COG0065@2|Bacteria,3J0IH@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
LZS2_k127_7918120_12	330214.NIDE4343	3.597e-58	206.0	2C3ZQ@1|root,32SCF@2|Bacteria	2|Bacteria	S	MEKHLA domain	-	-	-	-	-	-	-	-	-	-	-	-	MEKHLA
LZS2_k127_7918120_5	1218075.BAYA01000066_gene7099	6.96e-111	387.0	COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2VHGG@28216|Betaproteobacteria,1K1RI@119060|Burkholderiaceae	28216|Betaproteobacteria	M	cellulose synthase	bcsA	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glycos_transf_2,PilZ
LZS2_k127_7918120_20	644801.Psest_0801	1.658e-09	67.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,1SAIY@1236|Gammaproteobacteria,1Z15A@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	CBS-domain-containing membrane protein	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	CBS,HPP
LZS2_k127_7918120_9	330214.NIDE4140	2.065e-71	242.0	COG1145@1|root,COG1145@2|Bacteria,3J1BF@40117|Nitrospirae	40117|Nitrospirae	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7918120_11	330214.NIDE4139	2.463e-58	209.0	COG1430@1|root,COG1430@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
LZS2_k127_7918120_15	330214.NIDE4138	2.803e-51	183.0	COG2146@1|root,COG2146@2|Bacteria,3J1E7@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
LZS2_k127_7918120_7	330214.NIDE4136	7.744e-103	342.0	COG0115@1|root,COG0115@2|Bacteria	2|Bacteria	E	branched-chain-amino-acid transaminase activity	dat	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
LZS2_k127_7918120_14	330214.NIDE4135	2.202e-51	188.0	COG0779@1|root,COG0779@2|Bacteria,3J0UD@40117|Nitrospirae	40117|Nitrospirae	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
LZS2_k127_7918120_3	330214.NIDE4134	1.158e-212	664.0	COG0195@1|root,COG0195@2|Bacteria,3J0DF@40117|Nitrospirae	40117|Nitrospirae	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
LZS2_k127_7918120_0	330214.NIDE4133	0.0	1083.0	COG0532@1|root,COG0532@2|Bacteria,3J0CC@40117|Nitrospirae	40117|Nitrospirae	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
LZS2_k127_7918120_18	330214.NIDE4132	3.021e-33	130.0	COG1550@1|root,COG1550@2|Bacteria	2|Bacteria	H	Protein conserved in bacteria	ylxP	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
LZS2_k127_7918120_13	330214.NIDE4131	1.857e-51	185.0	COG0858@1|root,COG0858@2|Bacteria,3J0VV@40117|Nitrospirae	40117|Nitrospirae	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
LZS2_k127_7918120_8	330214.NIDE4130	2.714e-93	315.0	COG0130@1|root,COG0130@2|Bacteria,3J0KH@40117|Nitrospirae	40117|Nitrospirae	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
LZS2_k127_7918120_17	330214.NIDE4129	4.493e-42	156.0	COG0184@1|root,COG0184@2|Bacteria,3J0RA@40117|Nitrospirae	40117|Nitrospirae	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
LZS2_k127_7918120_2	1131269.AQVV01000001_gene1389	5.923e-245	773.0	COG1185@1|root,COG1185@2|Bacteria	2|Bacteria	J	polyribonucleotide nucleotidyltransferase activity	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
LZS2_k127_7920403_0	1340493.JNIF01000003_gene2317	6.294e-48	190.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	RHS_repeat
LZS2_k127_7922061_2	330214.NIDE2279	1.674e-06	49.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
LZS2_k127_7922061_0	330214.NIDE2280	1.959e-212	669.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Response_reg,Sigma54_activat
LZS2_k127_7922061_1	330214.NIDE2282	1.201e-89	316.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE2282|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_7924077_8	330214.NIDE1108	2.334e-17	81.0	COG1193@1|root,COG1193@2|Bacteria,3J0Y0@40117|Nitrospirae	40117|Nitrospirae	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
LZS2_k127_7924077_1	330214.NIDE1120	4.75e-141	460.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_7924077_4	330214.NIDE3350	1.205e-50	186.0	COG2010@1|root,COG2010@2|Bacteria,3J17C@40117|Nitrospirae	2|Bacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cytochrome_CBB3
LZS2_k127_7924077_6	330214.NIDE3686	3.435e-43	163.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	glbN	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
LZS2_k127_7924077_0	330214.NIDE2534	1.807e-143	460.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	aniA	-	1.16.3.3,1.7.2.1	ko:K00368,ko:K22349	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
LZS2_k127_7924077_2	330214.NIDE1121	7.816e-134	434.0	COG1600@1|root,COG1600@2|Bacteria,3J19A@40117|Nitrospirae	40117|Nitrospirae	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
LZS2_k127_7924077_9	1304275.C41B8_06502	7.311e-08	64.0	2C99D@1|root,2Z7Y8@2|Bacteria,1R5JY@1224|Proteobacteria,1SI3Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DNA-sulfur modification-associated	-	-	-	-	-	-	-	-	-	-	-	-	DndB
LZS2_k127_7924077_5	330214.NIDE1124	4.863e-49	183.0	COG2867@1|root,COG2867@2|Bacteria	2|Bacteria	I	negative regulation of translational initiation	sppD	-	2.3.1.235	ko:K05554,ko:K14670,ko:K15886	ko01056,ko01057,ko01130,map01056,map01057,map01130	M00778,M00783	R06701,R09265,R09269,R10960	RC00392,RC02496,RC02546	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Polyketide_cyc,Polyketide_cyc2
LZS2_k127_7924077_3	330214.NIDE2470	3.934e-68	240.0	COG0352@1|root,COG0352@2|Bacteria,3J0ND@40117|Nitrospirae	40117|Nitrospirae	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
LZS2_k127_7967756_1	643562.Daes_0129	1.73e-24	104.0	COG3676@1|root,COG3676@2|Bacteria,1QTF7@1224|Proteobacteria,42VZY@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	manually curated	-	-	-	ko:K07488	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1595
LZS2_k127_7967756_0	2340.JV46_09940	1.502e-148	476.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,1J63G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	IS30 family	ISPlu1B	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
LZS2_k127_7981632_0	671143.DAMO_1125	5.363e-21	100.0	COG0640@1|root,COG0640@2|Bacteria,2NQ4D@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR	-	-	ko:K03892,ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
LZS2_k127_7981657_0	1500893.JQNB01000001_gene3114	1.045e-105	360.0	COG3746@1|root,COG3746@2|Bacteria,1R45W@1224|Proteobacteria,1RNG5@1236|Gammaproteobacteria,1X52K@135614|Xanthomonadales	135614|Xanthomonadales	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
LZS2_k127_8004137_0	330214.NIDE4168	4.722e-182	576.0	COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,3J0Y7@40117|Nitrospirae	40117|Nitrospirae	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
LZS2_k127_8004137_1	330214.NIDE4167	2.613e-150	484.0	COG4638@1|root,COG4638@2|Bacteria	2|Bacteria	P	Rieske (2fe-2S)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
LZS2_k127_8004137_3	330214.NIDE4166	1.498e-94	311.0	COG2210@1|root,COG2210@2|Bacteria	2|Bacteria	P	Belongs to the sulfur carrier protein TusA family	cdr	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
LZS2_k127_8004137_4	330214.NIDE4165	3.398e-41	152.0	COG0425@1|root,COG0425@2|Bacteria,3J1C1@40117|Nitrospirae	40117|Nitrospirae	O	Sulfurtransferase TusA	-	-	-	-	-	-	-	-	-	-	-	-	TusA
LZS2_k127_8004137_2	330214.NIDE4164	6.168e-98	325.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria	2|Bacteria	E	Formiminotransferase domain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
LZS2_k127_8004857_2	1173026.Glo7428_4840	9.088e-94	318.0	COG0500@1|root,COG1414@1|root,COG0500@2|Bacteria,COG1414@2|Bacteria,1GQ10@1117|Cyanobacteria	1117|Cyanobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
LZS2_k127_8004857_0	1174684.EBMC1_12210	6.038e-146	477.0	COG2373@1|root,COG2373@2|Bacteria,1QXEG@1224|Proteobacteria,2TX94@28211|Alphaproteobacteria,2K8XX@204457|Sphingomonadales	204457|Sphingomonadales	C	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
LZS2_k127_8004857_5	1266925.JHVX01000017_gene14	5.731e-39	151.0	COG1359@1|root,COG1359@2|Bacteria,1N1AN@1224|Proteobacteria,2W3B4@28216|Betaproteobacteria,373KA@32003|Nitrosomonadales	28216|Betaproteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8004857_1	1266925.JHVX01000017_gene15	1.555e-142	458.0	COG4977@1|root,COG4977@2|Bacteria,1MXAU@1224|Proteobacteria,2VMRC@28216|Betaproteobacteria,372YH@32003|Nitrosomonadales	28216|Betaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18,HTH_AraC
LZS2_k127_8004857_4	330214.NIDE3628	2.376e-45	168.0	COG0023@1|root,COG0023@2|Bacteria	2|Bacteria	J	translation initiation factor activity	yciH	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
LZS2_k127_8004857_3	330214.NIDE2933	2.817e-89	297.0	COG0523@1|root,COG0523@2|Bacteria	2|Bacteria	P	cobalamin synthesis protein	COBW1	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
LZS2_k127_8023554_3	330214.NIDE3630	6.671e-19	86.0	COG4628@1|root,COG4628@2|Bacteria	2|Bacteria	S	conserved protein (DUF2132)	YPO1157	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363	-	ko:K06867	-	-	-	-	ko00000	-	-	-	VF530
LZS2_k127_8023554_0	1163617.SCD_n01360	3.679e-67	234.0	COG4681@1|root,COG4681@2|Bacteria,1RDR9@1224|Proteobacteria,2VR81@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM YaeQ family protein	yaeQ	-	-	-	-	-	-	-	-	-	-	-	YaeQ
LZS2_k127_8023554_1	33876.JNXY01000033_gene2222	1.525e-42	175.0	COG1305@1|root,COG1305@2|Bacteria,2IIM2@201174|Actinobacteria,4DGSH@85008|Micromonosporales	201174|Actinobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
LZS2_k127_8023554_2	497964.CfE428DRAFT_5635	2.134e-36	156.0	COG2307@1|root,COG2307@2|Bacteria,46S7Q@74201|Verrucomicrobia	74201|Verrucomicrobia	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
LZS2_k127_8066949_9	59196.RICGR_0957	3.559e-41	157.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	heptosyltransferase	rfaQ	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975	Glyco_transf_9
LZS2_k127_8066949_6	344747.PM8797T_05845	7.272e-91	306.0	COG1216@1|root,COG1216@2|Bacteria,2IZF5@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
LZS2_k127_8066949_0	614083.AWQR01000018_gene1774	9.45e-108	355.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,2VKUI@28216|Betaproteobacteria,4AJXQ@80864|Comamonadaceae	28216|Betaproteobacteria	M	Glycosyl transferase family 2	lgtF	-	-	ko:K12984	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2	-	Glycos_transf_2
LZS2_k127_8066949_8	1049564.TevJSym_bj00060	5.385e-47	185.0	COG1216@1|root,COG3307@1|root,COG1216@2|Bacteria,COG3307@2|Bacteria,1QU2Q@1224|Proteobacteria,1T1NF@1236|Gammaproteobacteria,1JC2J@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase family 2	waaE	-	-	ko:K12984	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2	-	Glyco_transf_7C,Glycos_transf_2
LZS2_k127_8066949_7	713586.KB900536_gene2504	3.796e-79	278.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1WW6T@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 4	-	-	-	ko:K13007	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
LZS2_k127_8066949_3	933262.AXAM01000009_gene1460	5.024e-95	322.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42PPG@68525|delta/epsilon subdivisions,2WJGF@28221|Deltaproteobacteria,2MJKB@213118|Desulfobacterales	28221|Deltaproteobacteria	M	epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
LZS2_k127_8066949_2	292415.Tbd_1874	8.122e-99	328.0	COG1216@1|root,COG1216@2|Bacteria,1RB30@1224|Proteobacteria,2VQYN@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	ko:K13002	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT2	-	Glycos_transf_2
LZS2_k127_8066949_1	1485544.JQKP01000002_gene1474	3.34e-104	351.0	COG0438@1|root,COG0438@2|Bacteria,1PEGM@1224|Proteobacteria,2VQC6@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
LZS2_k127_8066949_4	1116472.MGMO_4c00080	7.39e-95	320.0	COG0451@1|root,COG0451@2|Bacteria,1QRS2@1224|Proteobacteria,1T27G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
LZS2_k127_8066949_5	329726.AM1_3611	3.614e-94	316.0	COG0500@1|root,COG2226@2|Bacteria,1G5CW@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
LZS2_k127_8067389_1	330214.NIDE3491	3.463e-130	422.0	COG1538@1|root,COG1538@2|Bacteria,3J0N2@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
LZS2_k127_8067389_6	330214.NIDE0047	1.95e-79	269.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	tdsD	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
LZS2_k127_8067389_4	330214.NIDE0049	4.544e-105	346.0	COG1028@1|root,COG1028@2|Bacteria,3J0J6@40117|Nitrospirae	330214.NIDE0049|-	IQ	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
LZS2_k127_8067389_5	330214.NIDE0051	6.6e-87	291.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	2.1.1.63,3.2.2.21	ko:K00567,ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
LZS2_k127_8067389_2	330214.NIDE0052	3.458e-121	397.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Lactamase_B,Lactamase_B_5
LZS2_k127_8067389_0	330214.NIDE0058	2.215e-241	756.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	BT1,MFS_1
LZS2_k127_8067389_8	330214.NIDE3682	9.481e-32	126.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
LZS2_k127_8067389_3	330214.NIDE3680	4.009e-112	371.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
LZS2_k127_8067389_9	880073.Calab_2864	7.383e-20	90.0	COG0389@1|root,COG0389@2|Bacteria,2NP5S@2323|unclassified Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
LZS2_k127_8096049_5	1267534.KB906755_gene3904	7.138e-74	266.0	COG0729@1|root,COG0729@2|Bacteria	2|Bacteria	M	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
LZS2_k127_8096049_1	448385.sce6263	1.189e-101	349.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
LZS2_k127_8096049_0	234267.Acid_4777	0.0	1134.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,3Y2ZI@57723|Acidobacteria	57723|Acidobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
LZS2_k127_8096049_6	639030.JHVA01000001_gene3181	2.446e-53	200.0	2C6A3@1|root,34625@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8096049_7	1267534.KB906754_gene3089	1.734e-46	184.0	COG3064@1|root,COG3064@2|Bacteria,3Y7SB@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
LZS2_k127_8096049_3	335543.Sfum_1461	2.745e-89	308.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
LZS2_k127_8096049_4	237368.SCABRO_03833	1.139e-81	304.0	COG3264@1|root,COG3264@2|Bacteria,2IY5W@203682|Planctomycetes	203682|Planctomycetes	M	COG3264 Small-conductance mechanosensitive channel	-	-	-	ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.2,1.A.23.1.3	-	-	MS_channel
LZS2_k127_8096049_8	1166018.FAES_2874	4.341e-11	72.0	2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,47PKT@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
LZS2_k127_8096049_2	204669.Acid345_4082	2.891e-99	341.0	28QZS@1|root,2ZDEJ@2|Bacteria,3Y4BV@57723|Acidobacteria,2JKG1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8097825_0	330214.NIDE3046	0.0	1288.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
LZS2_k127_8097825_4	330214.NIDE3047	1.172e-102	344.0	COG0611@1|root,COG0611@2|Bacteria,3J0TF@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
LZS2_k127_8097825_5	330214.NIDE3048	7.567e-63	220.0	COG3216@1|root,COG3216@2|Bacteria,3J1DC@40117|Nitrospirae	40117|Nitrospirae	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
LZS2_k127_8097825_2	330214.NIDE3049	4.311e-264	818.0	COG1078@1|root,COG1078@2|Bacteria,3J0YB@40117|Nitrospirae	40117|Nitrospirae	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
LZS2_k127_8097825_6	395965.Msil_1166	4.411e-34	136.0	COG3177@1|root,COG3177@2|Bacteria,1MX0V@1224|Proteobacteria,2U88J@28211|Alphaproteobacteria,3NBZ2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,MerR_1
LZS2_k127_8097825_3	330214.NIDE3053	2.395e-124	406.0	COG0739@1|root,COG0739@2|Bacteria,3J16B@40117|Nitrospirae	40117|Nitrospirae	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
LZS2_k127_8097825_1	330214.NIDE3054	7.884e-280	862.0	COG0638@1|root,COG0638@2|Bacteria	2|Bacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
LZS2_k127_8112589_3	330214.NIDE2371	5.411e-09	63.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt,Response_reg
LZS2_k127_8112589_0	330214.NIDE2372	8.655e-81	278.0	COG2172@1|root,COG2204@1|root,COG2172@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	cpaE	-	2.7.11.1,2.7.13.3	ko:K02282,ko:K02482,ko:K04757,ko:K20977	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044,ko03021	-	-	-	HATPase_c,HATPase_c_2,HTH_18,HisKA,Response_reg
LZS2_k127_8112589_1	398767.Glov_1274	3.026e-42	167.0	COG3156@1|root,COG3156@2|Bacteria,1N9I4@1224|Proteobacteria,42V0N@68525|delta/epsilon subdivisions,2WRR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	PFAM General secretion pathway protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
LZS2_k127_8112589_2	1125863.JAFN01000001_gene2024	1.142e-15	85.0	COG3149@1|root,COG3149@2|Bacteria,1NEZ3@1224|Proteobacteria,42WMP@68525|delta/epsilon subdivisions,2WSE1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein M	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
LZS2_k127_8112589_5	221288.JH992901_gene1779	0.0001141	55.0	COG4972@1|root,COG4972@2|Bacteria,1G0A3@1117|Cyanobacteria,1JGT6@1189|Stigonemataceae	1117|Cyanobacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
LZS2_k127_8215731_2	1380391.JIAS01000011_gene4856	1.32e-56	201.0	COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,2U8J8@28211|Alphaproteobacteria,2JXS8@204441|Rhodospirillales	204441|Rhodospirillales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8215731_4	1403819.BATR01000114_gene3952	1.103e-41	157.0	COG0346@1|root,COG0346@2|Bacteria,46VWA@74201|Verrucomicrobia,2IVZP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
LZS2_k127_8215731_7	525904.Tter_2787	5.694e-23	104.0	2FDIX@1|root,345KC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8215731_9	43989.cce_4503	0.0008316	44.0	COG0346@1|root,COG0346@2|Bacteria,1GDQB@1117|Cyanobacteria,3KIA7@43988|Cyanothece	1117|Cyanobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
LZS2_k127_8215731_3	382464.ABSI01000011_gene2994	7.608e-47	174.0	2DQ7E@1|root,3353C@2|Bacteria,46SU5@74201|Verrucomicrobia,2IUQR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
LZS2_k127_8215731_0	330214.NIDE3598	1.956e-147	472.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
LZS2_k127_8215731_1	272134.KB731324_gene1973	4.528e-76	291.0	COG0784@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1GPYK@1117|Cyanobacteria,1HI2H@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal Transduction Histidine Kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS2_k127_8215731_5	378806.STAUR_7783	4.699e-40	154.0	COG3265@1|root,COG3265@2|Bacteria,1RHD0@1224|Proteobacteria,43818@68525|delta/epsilon subdivisions,2X9US@28221|Deltaproteobacteria,2YV7Z@29|Myxococcales	28221|Deltaproteobacteria	F	Shikimate kinase	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	SKI
LZS2_k127_8215731_6	700598.Niako_1582	1.659e-25	110.0	2C3CF@1|root,32RRR@2|Bacteria,4NUPT@976|Bacteroidetes,1IU1J@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
LZS2_k127_8258032_12	706587.Desti_2788	3.43e-06	59.0	COG0457@1|root,COG0457@2|Bacteria,1RKBA@1224|Proteobacteria	1224|Proteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LprI,Peptidase_C14,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
LZS2_k127_8258032_11	1009370.ALO_10419	7.282e-10	71.0	COG1750@1|root,COG1750@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lon_C,SdrD_B
LZS2_k127_8258032_10	553217.ENHAE0001_2453	3.386e-17	84.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,3NNWH@468|Moraxellaceae	1236|Gammaproteobacteria	S	YCII-related domain	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05527,ko:K09780	-	-	-	-	ko00000,ko03000	-	-	-	YCII
LZS2_k127_8258032_7	330214.NIDE0974	4.171e-49	179.0	COG4911@1|root,COG4911@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
LZS2_k127_8258032_0	330214.NIDE0975	2.454e-267	824.0	COG1158@1|root,COG1158@2|Bacteria,3J0BK@40117|Nitrospirae	40117|Nitrospirae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
LZS2_k127_8258032_9	330214.NIDE0976	1.844e-36	138.0	COG0254@1|root,COG0254@2|Bacteria,3J0S4@40117|Nitrospirae	40117|Nitrospirae	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
LZS2_k127_8258032_3	330214.NIDE0977	1.984e-161	515.0	COG0216@1|root,COG0216@2|Bacteria,3J0F6@40117|Nitrospirae	40117|Nitrospirae	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
LZS2_k127_8258032_6	330214.NIDE0978	3.498e-70	247.0	COG2890@1|root,COG2890@2|Bacteria,3J0N5@40117|Nitrospirae	40117|Nitrospirae	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
LZS2_k127_8258032_2	330214.NIDE0979	2.674e-199	628.0	COG0766@1|root,COG0766@2|Bacteria,3J0EE@40117|Nitrospirae	40117|Nitrospirae	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
LZS2_k127_8258032_5	330214.NIDE0980	8.82e-91	304.0	COG0040@1|root,COG0040@2|Bacteria,3J0T5@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
LZS2_k127_8258032_1	330214.NIDE0981	1.088e-218	685.0	COG0141@1|root,COG0141@2|Bacteria,3J0C6@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
LZS2_k127_8258032_4	330214.NIDE0982	9.97e-115	371.0	COG0131@1|root,COG0131@2|Bacteria,3J0JI@40117|Nitrospirae	40117|Nitrospirae	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
LZS2_k127_8258032_8	35841.BT1A1_1799	1.327e-42	159.0	COG2445@1|root,COG2445@2|Bacteria,1V6HC@1239|Firmicutes,4HJA7@91061|Bacilli,1ZH3D@1386|Bacillus	91061|Bacilli	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
LZS2_k127_8258182_1	330214.NIDE2983	8.009e-225	704.0	COG1109@1|root,COG1109@2|Bacteria,3J0AF@40117|Nitrospirae	40117|Nitrospirae	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
LZS2_k127_8258182_6	330214.NIDE2982	1.135e-72	254.0	COG3170@1|root,COG3170@2|Bacteria,3J1DA@40117|Nitrospirae	40117|Nitrospirae	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
LZS2_k127_8258182_3	32057.KB217478_gene4809	4.42e-115	379.0	COG0158@1|root,COG0158@2|Bacteria,1G0KA@1117|Cyanobacteria,1HJ0Q@1161|Nostocales	1117|Cyanobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
LZS2_k127_8258182_2	330214.NIDE2980	6.088e-177	557.0	COG1830@1|root,COG1830@2|Bacteria,3J1DE@40117|Nitrospirae	40117|Nitrospirae	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
LZS2_k127_8258182_0	330214.NIDE2979	2.696e-244	763.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	2|Bacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
LZS2_k127_8258182_5	330214.NIDE2977	1.656e-96	320.0	COG1211@1|root,COG1211@2|Bacteria,3J18C@40117|Nitrospirae	40117|Nitrospirae	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
LZS2_k127_8258182_7	330214.NIDE2976	7.992e-66	229.0	COG0245@1|root,COG0245@2|Bacteria,3J0N6@40117|Nitrospirae	40117|Nitrospirae	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
LZS2_k127_8258182_4	330214.NIDE2975	1.851e-108	353.0	COG1045@1|root,COG1045@2|Bacteria,3J11G@40117|Nitrospirae	40117|Nitrospirae	E	Serine acetyltransferase, N-terminal	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
LZS2_k127_8274455_5	330214.NIDE1465	8.654e-138	439.0	COG1013@1|root,COG1013@2|Bacteria,3J10F@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
LZS2_k127_8274455_9	1382359.JIAL01000001_gene1053	2.999e-05	51.0	2C987@1|root,331JK@2|Bacteria,3Y5R0@57723|Acidobacteria,2JK28@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8274455_3	357808.RoseRS_4538	3.523e-164	523.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi,377XZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
LZS2_k127_8274455_2	330214.NIDE3283	4.885e-204	646.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_8274455_0	330214.NIDE3284	0.0	1403.0	COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_4
LZS2_k127_8274455_4	330214.NIDE3286	3.681e-148	475.0	COG0341@1|root,COG0341@2|Bacteria,3J0GM@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
LZS2_k127_8274455_1	330214.NIDE3287	1.404e-261	815.0	COG0342@1|root,COG0342@2|Bacteria,3J09Z@40117|Nitrospirae	40117|Nitrospirae	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
LZS2_k127_8274455_8	330214.NIDE3288	1.444e-23	101.0	COG1862@1|root,COG1862@2|Bacteria,3J0UB@40117|Nitrospirae	40117|Nitrospirae	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
LZS2_k127_8286193_4	330214.NIDE0329	1.251e-45	169.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
LZS2_k127_8286193_2	330214.NIDE0330	2.622e-63	224.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
LZS2_k127_8286193_6	330214.NIDE0331	1.806e-28	117.0	COG2835@1|root,COG2835@2|Bacteria	2|Bacteria	EG	tetraacyldisaccharide 4'-kinase activity	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Methyltransf_25,Trm112p
LZS2_k127_8286193_7	1499967.BAYZ01000136_gene57	4.822e-14	76.0	2EUYT@1|root,33NE0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8286193_0	330214.NIDE3236	5.673e-301	923.0	COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae	2|Bacteria	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	ddhB	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.5.1	ko:K00371,ko:K16965,ko:K17048,ko:K17051	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Fer4_11
LZS2_k127_8286193_5	330214.NIDE3255	1.403e-31	123.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	ddhA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.17.99.2,1.7.5.1,1.8.2.4	ko:K00370,ko:K10700,ko:K16964,ko:K17050	ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020	M00529,M00530,M00804	R00798,R01106,R05745,R09497,R09500	RC00275,RC02555,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8,5.A.3.9	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
LZS2_k127_830542_1	330214.NIDE0298	9.738e-156	496.0	COG1220@1|root,COG1220@2|Bacteria,3J0XE@40117|Nitrospirae	40117|Nitrospirae	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
LZS2_k127_830542_2	330214.NIDE0297	3.377e-83	287.0	COG5405@1|root,COG5405@2|Bacteria,3J10R@40117|Nitrospirae	40117|Nitrospirae	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
LZS2_k127_830542_3	930169.B5T_01422	1.884e-56	208.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XHYC@135619|Oceanospirillales	135619|Oceanospirillales	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
LZS2_k127_830542_0	330214.NIDE0295	1.218e-230	720.0	COG1206@1|root,COG1206@2|Bacteria,3J0WT@40117|Nitrospirae	40117|Nitrospirae	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
LZS2_k127_830542_4	330214.NIDE0294	1.762e-09	58.0	COG4974@1|root,COG4974@2|Bacteria,3J1FQ@40117|Nitrospirae	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_5,Phage_integrase
LZS2_k127_839354_6	330214.NIDE0711	2.458e-32	128.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
LZS2_k127_839354_2	330214.NIDE1200	5.603e-117	379.0	COG0819@1|root,COG0819@2|Bacteria	2|Bacteria	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	tenA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
LZS2_k127_839354_1	330214.NIDE1201	3.37e-221	694.0	COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	1.6.1.1,1.8.1.4	ko:K00322,ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map00760,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00112,R00209,R01221,R01698,R03815,R07618,R08549	RC00001,RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
LZS2_k127_839354_4	330214.NIDE1202	2.067e-91	308.0	COG2077@1|root,COG2077@2|Bacteria	2|Bacteria	O	thioredoxin peroxidase activity	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA,Redoxin
LZS2_k127_839354_3	330214.NIDE1203	2.665e-105	351.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
LZS2_k127_839354_0	330214.NIDE1204	0.0	1019.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,3J10I@40117|Nitrospirae	40117|Nitrospirae	C	Conserved carboxylase domain	-	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
LZS2_k127_839354_5	330214.NIDE1205	5.275e-52	184.0	COG0439@1|root,COG0439@2|Bacteria,3J0YP@40117|Nitrospirae	40117|Nitrospirae	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
LZS2_k127_8467053_2	330214.NIDE2291	8.889e-14	72.0	COG1157@1|root,COG1157@2|Bacteria,3J0BV@40117|Nitrospirae	40117|Nitrospirae	N	ATP synthase alpha/beta family, beta-barrel domain	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
LZS2_k127_8467053_0	330214.NIDE2290	2.546e-64	234.0	COG1317@1|root,COG2204@1|root,COG1317@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	hrpE	-	-	ko:K02411,ko:K03223,ko:K03413	ko02020,ko02030,ko02040,ko03070,map02020,map02030,map02040,map03070	M00332,M00506,M00660	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	FliH,HrpE,NolV,Response_reg,TPR_16,TPR_19
LZS2_k127_8467053_1	1121413.JMKT01000008_gene1404	1.432e-32	129.0	COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,42MS3@68525|delta/epsilon subdivisions,2WMCR@28221|Deltaproteobacteria,2M8WS@213115|Desulfovibrionales	28221|Deltaproteobacteria	N	flagellar motor switch protein FliG	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
LZS2_k127_8475608_4	330214.NIDE3556	6.747e-51	185.0	COG0720@1|root,COG0720@2|Bacteria	2|Bacteria	H	synthase	ygcM	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
LZS2_k127_8475608_2	330214.NIDE3555	4.672e-96	318.0	COG0302@1|root,COG0302@2|Bacteria,3J0Q0@40117|Nitrospirae	40117|Nitrospirae	F	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
LZS2_k127_8475608_1	330214.NIDE3554	1.624e-96	323.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	pcaD	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
LZS2_k127_8475608_0	1499967.BAYZ01000028_gene1352	2.195e-138	453.0	COG2256@1|root,COG2256@2|Bacteria,2NNTG@2323|unclassified Bacteria	2|Bacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
LZS2_k127_8475608_5	330214.NIDE3551	2.711e-16	79.0	COG0488@1|root,COG0488@2|Bacteria,3J0W6@40117|Nitrospirae	40117|Nitrospirae	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
LZS2_k127_8502389_1	330214.NIDE0722	5.004e-84	285.0	COG1018@1|root,COG1018@2|Bacteria	330214.NIDE0722|-	C	nitric oxide dioxygenase activity	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	-
LZS2_k127_8502389_0	330214.NIDE1893	1.694e-129	425.0	COG0116@1|root,COG0116@2|Bacteria	2|Bacteria	L	23S rRNA (guanine(2445)-N(2))-methyltransferase activity	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016423,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
LZS2_k127_8502389_2	330214.NIDE1894	7.02e-75	255.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,Nudix_N_2
LZS2_k127_8502389_3	330214.NIDE1896	2.568e-33	130.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
LZS2_k127_8502389_8	330214.NIDE1914	2.066e-06	54.0	COG1194@1|root,COG1194@2|Bacteria,3J160@40117|Nitrospirae	40117|Nitrospirae	L	FES	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
LZS2_k127_8525606_2	313596.RB2501_07250	8.223e-11	66.0	COG0607@1|root,COG0607@2|Bacteria,4NQ61@976|Bacteroidetes,1I2V7@117743|Flavobacteriia	976|Bacteroidetes	P	Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
LZS2_k127_8525606_0	357808.RoseRS_3276	5.704e-188	599.0	COG2308@1|root,COG2308@2|Bacteria,2GACA@200795|Chloroflexi,37575@32061|Chloroflexia	32061|Chloroflexia	S	A circularly permuted ATPgrasp	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
LZS2_k127_8525606_1	382464.ABSI01000011_gene2677	6.62e-25	108.0	COG2307@1|root,COG2307@2|Bacteria,46S7Q@74201|Verrucomicrobia,2IU62@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
LZS2_k127_8558843_0	330214.NIDE3941	8.686e-160	517.0	COG2202@1|root,COG3290@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG3290@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,3J124@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
LZS2_k127_8558843_5	330214.NIDE3940	1.834e-46	170.0	COG0745@1|root,COG0745@2|Bacteria	330214.NIDE3940|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8558843_1	641491.DND132_1358	3.872e-83	293.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
LZS2_k127_8558843_4	330214.NIDE3929	1.667e-59	213.0	COG3074@1|root,COG3074@2|Bacteria	2|Bacteria	D	FtsZ-dependent cytokinesis	zapB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044424,GO:0044444,GO:0044464,GO:0051301	2.1.1.80,3.1.1.61	ko:K09892,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko03036	-	-	-	ZapB
LZS2_k127_8558843_6	330214.NIDE3927	8.16e-34	135.0	COG5615@1|root,COG5615@2|Bacteria	2|Bacteria	L	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CopD
LZS2_k127_8558843_2	330214.NIDE4035	2.177e-71	261.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
LZS2_k127_8558843_3	330214.NIDE3923	7.56e-64	222.0	2ED3M@1|root,3370H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
LZS2_k127_8571076_0	330214.NIDE2475	0.0	1040.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512,iYO844.BSU37780	Aldedh,Pro_dh
LZS2_k127_8571076_1	330214.NIDE2473	8.859e-72	250.0	COG1028@1|root,COG1028@2|Bacteria	330214.NIDE2473|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
LZS2_k127_8571076_2	330214.NIDE2471	5.688e-56	207.0	COG0132@1|root,COG0132@2|Bacteria,3J0SI@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
LZS2_k127_8591046_5	1297742.A176_02252	1.684e-72	254.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,42QY6@68525|delta/epsilon subdivisions,2WN05@28221|Deltaproteobacteria,2YV4R@29|Myxococcales	28221|Deltaproteobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
LZS2_k127_8591046_4	485915.Dret_1224	8.467e-92	316.0	COG0053@1|root,COG1433@1|root,COG0053@2|Bacteria,COG1433@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WKDR@28221|Deltaproteobacteria,2MEZE@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,Nitro_FeMo-Co,ZT_dimer
LZS2_k127_8591046_6	395494.Galf_2194	2.179e-52	192.0	COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,2WCP5@28216|Betaproteobacteria,44WF7@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
LZS2_k127_8591046_7	671143.DAMO_1951	1.221e-30	128.0	COG3678@1|root,COG3678@2|Bacteria	2|Bacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
LZS2_k127_8591046_1	330214.NIDE4060	2.445e-159	509.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
LZS2_k127_8591046_0	330214.NIDE3882	9.534e-193	612.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K12263	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3,SirB
LZS2_k127_8591046_3	330214.NIDE4060	1.365e-112	370.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
LZS2_k127_8591046_9	1123508.JH636439_gene1282	2.838e-10	66.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
LZS2_k127_8591046_2	56780.SYN_01164	5.74e-154	493.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_8591046_8	472759.Nhal_0815	9.576e-17	83.0	COG4902@1|root,COG4902@2|Bacteria,1QW29@1224|Proteobacteria,1S7N1@1236|Gammaproteobacteria,1X10I@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8614607_8	330214.NIDE2809	4.661e-34	132.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
LZS2_k127_8614607_7	330214.NIDE2808	2.668e-56	208.0	COG1595@1|root,COG1595@2|Bacteria,3J17D@40117|Nitrospirae	40117|Nitrospirae	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS2_k127_8614607_4	1193181.BN10_1060003	1.06e-147	484.0	COG2373@1|root,COG2373@2|Bacteria,2GTY9@201174|Actinobacteria	201174|Actinobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
LZS2_k127_8614607_2	330214.NIDE3618	2.866e-175	558.0	COG2081@1|root,COG2081@2|Bacteria	2|Bacteria	N	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
LZS2_k127_8614607_3	330214.NIDE2583	9.13e-165	522.0	COG0825@1|root,COG0825@2|Bacteria,3J0CN@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
LZS2_k127_8614607_0	1499967.BAYZ01000009_gene5298	0.0	1211.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
LZS2_k127_8614607_9	330214.NIDE2576	6.814e-15	89.0	COG1196@1|root,COG3743@1|root,COG1196@2|Bacteria,COG3743@2|Bacteria	2|Bacteria	S	rRNA binding	-	-	-	ko:K00185,ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	5.A.3	-	-	NrfD
LZS2_k127_8614607_1	330214.NIDE4286	1.345e-197	627.0	COG0469@1|root,COG0469@2|Bacteria,3J0XM@40117|Nitrospirae	40117|Nitrospirae	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
LZS2_k127_8614607_5	330214.NIDE2345	1.897e-110	364.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	ylxH-3	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
LZS2_k127_8618818_3	330214.NIDE0595	5.317e-16	78.0	COG0322@1|root,COG0322@2|Bacteria,3J0F1@40117|Nitrospirae	40117|Nitrospirae	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
LZS2_k127_8618818_0	330214.NIDE0596	8.026e-156	495.0	COG0253@1|root,COG0253@2|Bacteria,3J0JV@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
LZS2_k127_8618818_2	330214.NIDE0597	1.195e-64	222.0	COG0346@1|root,COG0346@2|Bacteria,3J15P@40117|Nitrospirae	40117|Nitrospirae	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
LZS2_k127_8618818_1	330214.NIDE0600	3.774e-131	425.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,3J0VG@40117|Nitrospirae	40117|Nitrospirae	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
LZS2_k127_8652695_1	1265502.KB905941_gene2934	3.555e-105	347.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,4ABF7@80864|Comamonadaceae	28216|Betaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_8652695_0	1265502.KB905941_gene2933	0.0	1169.0	COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,2VRRA@28216|Betaproteobacteria	28216|Betaproteobacteria	N	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
LZS2_k127_8652695_2	1121439.dsat_0127	7.553e-85	292.0	2C6D0@1|root,31F07@2|Bacteria,1RHBN@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
LZS2_k127_8652695_3	671143.DAMO_0603	1.129e-09	63.0	2C2YU@1|root,33M8J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8652695_4	1122130.AUHN01000005_gene2443	4.566e-09	59.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
LZS2_k127_8727665_1	330214.NIDE2540	2.237e-131	425.0	COG0044@1|root,COG0044@2|Bacteria,3J0D7@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
LZS2_k127_8727665_0	330214.NIDE2539	1.086e-164	521.0	COG0540@1|root,COG0540@2|Bacteria,3J0FJ@40117|Nitrospirae	40117|Nitrospirae	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
LZS2_k127_8727665_2	330214.NIDE2538	8.279e-80	267.0	COG2065@1|root,COG2065@2|Bacteria,3J0JX@40117|Nitrospirae	40117|Nitrospirae	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
LZS2_k127_8732152_6	330214.NIDE2814	1.898e-49	181.0	COG0607@1|root,COG0607@2|Bacteria,3J1F1@40117|Nitrospirae	40117|Nitrospirae	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
LZS2_k127_8732152_2	330214.NIDE3181	5.425e-140	450.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	yihR	GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
LZS2_k127_8732152_5	237727.NAP1_06510	1.498e-81	281.0	COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2TW27@28211|Alphaproteobacteria,2KE98@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
LZS2_k127_8732152_7	886293.Sinac_1713	4.949e-43	166.0	COG1301@1|root,COG1301@2|Bacteria,2IYUE@203682|Planctomycetes	203682|Planctomycetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K03309,ko:K11102,ko:K11103	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.23,2.A.23.1.1,2.A.23.1.2,2.A.23.1.3,2.A.23.1.6,2.A.23.1.7	-	-	SDF
LZS2_k127_8732152_4	330214.NIDE1569	3.045e-94	319.0	COG1301@1|root,COG1301@2|Bacteria	2|Bacteria	C	dicarboxylic acid transport	-	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
LZS2_k127_8732152_0	330214.NIDE2638	0.0	1375.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,3J0ZS@40117|Nitrospirae	40117|Nitrospirae	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
LZS2_k127_8732152_3	330214.NIDE2639	1.095e-116	383.0	COG1052@1|root,COG1052@2|Bacteria,3J13M@40117|Nitrospirae	40117|Nitrospirae	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
LZS2_k127_8732152_1	330214.NIDE2640	1.389e-175	574.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE2640|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8732152_8	330214.NIDE2641	3.901e-37	140.0	COG1278@1|root,COG1278@2|Bacteria,3J0QZ@40117|Nitrospirae	40117|Nitrospirae	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
LZS2_k127_8760946_5	330214.NIDE3444	5.491e-210	656.0	COG0075@1|root,COG0075@2|Bacteria,3J0FC@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
LZS2_k127_8760946_2	330214.NIDE3443	7.429e-274	850.0	COG0111@1|root,COG4747@1|root,COG0111@2|Bacteria,COG4747@2|Bacteria,3J0DZ@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
LZS2_k127_8760946_11	330214.NIDE3442	1.454e-128	425.0	COG3705@1|root,COG3705@2|Bacteria,3J13R@40117|Nitrospirae	40117|Nitrospirae	E	Histidyl-tRNA synthetase	-	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
LZS2_k127_8760946_3	330214.NIDE3441	1.036e-242	754.0	COG0305@1|root,COG0305@2|Bacteria,3J0EZ@40117|Nitrospirae	40117|Nitrospirae	L	Participates in initiation and elongation during chromosome replication	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
LZS2_k127_8760946_4	330214.NIDE3440	8.253e-217	689.0	COG0457@1|root,COG0457@2|Bacteria,3J0MH@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
LZS2_k127_8760946_25	330214.NIDE3438	5.929e-20	98.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	pilA	GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin_PilA
LZS2_k127_8760946_18	330214.NIDE3436	1.807e-53	200.0	COG0457@1|root,COG0457@2|Bacteria	330214.NIDE3436|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8760946_14	330214.NIDE3435	3.311e-100	336.0	COG1131@1|root,COG1131@2|Bacteria,3J122@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS2_k127_8760946_16	330214.NIDE3434	3.719e-67	237.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	pilI	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
LZS2_k127_8760946_0	330214.NIDE3406	9.766e-316	972.0	COG0129@1|root,COG0129@2|Bacteria,3J0ES@40117|Nitrospirae	40117|Nitrospirae	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
LZS2_k127_8760946_17	330214.NIDE3404	4.615e-57	207.0	COG3678@1|root,COG3678@2|Bacteria	2|Bacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ,Metal_resist
LZS2_k127_8760946_12	330214.NIDE3402	1.46e-128	420.0	COG0484@1|root,COG0484@2|Bacteria,3J0A7@40117|Nitrospirae	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
LZS2_k127_8760946_10	330214.NIDE3396	4.594e-149	479.0	COG0037@1|root,COG0037@2|Bacteria,3J0JK@40117|Nitrospirae	40117|Nitrospirae	H	PP-loop family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
LZS2_k127_8760946_20	330214.NIDE2560	9.464e-37	147.0	COG0569@1|root,COG0569@2|Bacteria	2|Bacteria	P	domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2,TrkA_C
LZS2_k127_8760946_6	330214.NIDE2561	1.079e-193	614.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
LZS2_k127_8760946_7	316067.Geob_2386	5.458e-192	622.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,43RZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	elongation factor Tu domain 2 protein	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
LZS2_k127_8760946_13	330214.NIDE2563	1.617e-100	333.0	COG2003@1|root,COG2003@2|Bacteria,3J0HV@40117|Nitrospirae	40117|Nitrospirae	E	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
LZS2_k127_8760946_23	330214.NIDE2564	7.258e-28	112.0	2EI4B@1|root,33BVP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8760946_19	330214.NIDE2565	3.743e-48	183.0	COG0742@1|root,COG0742@2|Bacteria,3J0V5@40117|Nitrospirae	40117|Nitrospirae	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
LZS2_k127_8760946_15	330214.NIDE2566	1.535e-77	264.0	COG0669@1|root,COG0669@2|Bacteria,3J0MF@40117|Nitrospirae	40117|Nitrospirae	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
LZS2_k127_8760946_8	330214.NIDE2567	1.159e-191	605.0	COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae	40117|Nitrospirae	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
LZS2_k127_8760946_24	330214.NIDE2568	4.414e-27	114.0	COG2331@1|root,COG2331@2|Bacteria,3J0V8@40117|Nitrospirae	40117|Nitrospirae	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
LZS2_k127_8760946_9	330214.NIDE2573	1.397e-189	600.0	COG0151@1|root,COG0151@2|Bacteria,3J0H5@40117|Nitrospirae	40117|Nitrospirae	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
LZS2_k127_8760946_1	330214.NIDE2574	4.42e-285	881.0	COG0138@1|root,COG0138@2|Bacteria,3J0CV@40117|Nitrospirae	40117|Nitrospirae	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
LZS2_k127_8760946_21	204669.Acid345_0949	4.411e-34	136.0	2EBAA@1|root,335AW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
LZS2_k127_8760946_22	398767.Glov_2205	3.107e-28	124.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,43UXK@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
LZS2_k127_8840036_9	746697.Aeqsu_2026	3.825e-91	308.0	COG1878@1|root,COG1878@2|Bacteria,4NFYB@976|Bacteroidetes,1IIVK@117743|Flavobacteriia	976|Bacteroidetes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
LZS2_k127_8840036_12	247490.KSU1_D0178	2.309e-82	280.0	COG2410@1|root,COG2410@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF429)	-	-	-	ko:K09147	-	-	-	-	ko00000	-	-	-	DUF429
LZS2_k127_8840036_4	330214.NIDE0784	6.493e-173	552.0	COG5274@1|root,COG5274@2|Bacteria	2|Bacteria	C	heme binding	-	-	1.13.11.52	ko:K00463	ko00380,ko01100,ko05143,map00380,map01100,map05143	M00038	R00678,R02702,R02909,R03628	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyt-b5,FAD_binding_1,IDO,NAD_binding_1
LZS2_k127_8840036_1	330214.NIDE0845	1.569e-245	761.0	COG0499@1|root,COG0499@2|Bacteria,3J0AH@40117|Nitrospirae	40117|Nitrospirae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
LZS2_k127_8840036_2	330214.NIDE0846	1.441e-229	716.0	COG0192@1|root,COG0192@2|Bacteria,3J0A4@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
LZS2_k127_8840036_13	330214.NIDE0850	2.108e-61	216.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
LZS2_k127_8840036_5	330214.NIDE0851	5.495e-132	424.0	COG0785@1|root,COG0785@2|Bacteria,3J0KU@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
LZS2_k127_8840036_10	330214.NIDE0853	3.226e-88	302.0	COG4105@1|root,COG4105@2|Bacteria,3J0UU@40117|Nitrospirae	40117|Nitrospirae	S	Tetratricopeptide repeat	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
LZS2_k127_8840036_6	330214.NIDE0854	3.94e-123	402.0	COG0332@1|root,COG0332@2|Bacteria,3J0FW@40117|Nitrospirae	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
LZS2_k127_8840036_7	671143.DAMO_1128	2.301e-115	394.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
LZS2_k127_8840036_8	330214.NIDE0858	1.985e-109	359.0	COG0745@1|root,COG0745@2|Bacteria,3J0JU@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
LZS2_k127_8840036_3	330214.NIDE0859	8.936e-180	565.0	COG0761@1|root,COG0761@2|Bacteria,3J0PP@40117|Nitrospirae	40117|Nitrospirae	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
LZS2_k127_8840036_0	330214.NIDE0860	0.0	1290.0	COG1196@1|root,COG1196@2|Bacteria,3J0W4@40117|Nitrospirae	40117|Nitrospirae	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
LZS2_k127_8840036_11	909663.KI867150_gene245	1.036e-84	288.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MQNC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
LZS2_k127_8848270_22	330214.NIDE3623	0.0001527	46.0	COG0656@1|root,COG0656@2|Bacteria	2|Bacteria	S	aldo-keto reductase (NADP) activity	ytbE	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,DUF4157
LZS2_k127_8848270_4	1131553.JIBI01000051_gene965	5.202e-201	636.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,2VICB@28216|Betaproteobacteria,373T8@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	NQRA,NQRA_SLBB
LZS2_k127_8848270_3	1131553.JIBI01000051_gene966	4.372e-208	652.0	COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2WBWD@28216|Betaproteobacteria,373ZW@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
LZS2_k127_8848270_13	228410.NE2395	2.905e-91	308.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,2VQXA@28216|Betaproteobacteria,373YH@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
LZS2_k127_8848270_12	1131553.JIBI01000051_gene968	7.424e-98	323.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,2VM5K@28216|Betaproteobacteria,3744J@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
LZS2_k127_8848270_11	1131553.JIBI01000051_gene969	2.118e-100	330.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,2WIF5@28216|Betaproteobacteria,373T9@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
LZS2_k127_8848270_2	1415780.JPOG01000001_gene110	3.628e-212	665.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1X6HX@135614|Xanthomonadales	135614|Xanthomonadales	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1,PepSY_TM
LZS2_k127_8848270_9	1131553.JIBI01000051_gene971	2.658e-120	395.0	COG1477@1|root,COG2991@1|root,COG1477@2|Bacteria,COG2991@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,371SS@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
LZS2_k127_8848270_17	85643.Tmz1t_2286	3.906e-16	80.0	COG2991@1|root,COG2991@2|Bacteria	2|Bacteria	H	Protein conserved in bacteria	Z012_07620	-	2.7.1.180	ko:K03734,ko:K05952	-	-	-	-	ko00000,ko01000	-	-	-	NqrM
LZS2_k127_8848270_10	330214.NIDE3643	1.837e-111	365.0	COG0221@1|root,COG0221@2|Bacteria,3J184@40117|Nitrospirae	40117|Nitrospirae	C	Inorganic pyrophosphatase	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
LZS2_k127_8848270_6	322710.Avin_20870	1.007e-162	530.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
LZS2_k127_8848270_8	330214.NIDE2794	1.833e-134	432.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
LZS2_k127_8848270_7	330214.NIDE2795	1.924e-161	513.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_6,HTH_18
LZS2_k127_8848270_5	330214.NIDE4063	1.288e-177	561.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	lysDH	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
LZS2_k127_8848270_0	330214.NIDE4062	4.106e-241	753.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	pcd	GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
LZS2_k127_8848270_14	330214.NIDE4061	6.151e-86	295.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
LZS2_k127_8848270_18	1123279.ATUS01000001_gene2023	2.3e-12	71.0	COG2149@1|root,COG2149@2|Bacteria,1QD8W@1224|Proteobacteria,1THAR@1236|Gammaproteobacteria,1JBG4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF202
LZS2_k127_8848270_1	264201.pc1573	1.083e-226	713.0	COG4108@1|root,COG4108@2|Bacteria,2JFKT@204428|Chlamydiae	204428|Chlamydiae	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	-	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
LZS2_k127_8848270_15	330214.NIDE3490	8.046e-60	212.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
LZS2_k127_8848270_21	1191460.F959_02531	5.419e-05	51.0	2EGFZ@1|root,33A7Y@2|Bacteria,1NI1P@1224|Proteobacteria,1SVCS@1236|Gammaproteobacteria,3NPF6@468|Moraxellaceae	1236|Gammaproteobacteria	S	Ribosomal protein L7/L12 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L12
LZS2_k127_8848270_19	330214.NIDE1600	1.941e-11	75.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Big_3,PT-HINT,RHS_repeat
LZS2_k127_8853489_1	330214.NIDE0563	4.306e-147	468.0	COG1032@1|root,COG1032@2|Bacteria,3J0WM@40117|Nitrospirae	40117|Nitrospirae	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
LZS2_k127_8853489_0	330214.NIDE0562	0.0	1206.0	COG0589@1|root,COG1592@1|root,COG0589@2|Bacteria,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	usp1	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	DinB_2,Rubrerythrin,Usp
LZS2_k127_8853489_2	330214.NIDE0561	6.895e-39	147.0	COG0535@1|root,COG0535@2|Bacteria,3J10V@40117|Nitrospirae	40117|Nitrospirae	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
LZS2_k127_8918415_11	2074.JNYD01000026_gene647	1.12e-44	167.0	COG1765@1|root,COG1765@2|Bacteria,2IG8A@201174|Actinobacteria	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
LZS2_k127_8918415_12	1123368.AUIS01000032_gene1401	8.121e-32	129.0	2D5Q1@1|root,32TJK@2|Bacteria,1N688@1224|Proteobacteria,1SS8Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS2_k127_8918415_0	290397.Adeh_2253	8.269e-219	697.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
LZS2_k127_8918415_8	1288494.EBAPG3_21750	1.846e-69	244.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,3733I@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
LZS2_k127_8918415_9	1443665.JACA01000020_gene4947	6.237e-52	190.0	COG1988@1|root,COG1988@2|Bacteria,4NPMW@976|Bacteroidetes,1I2P2@117743|Flavobacteriia,2YIQT@290174|Aquimarina	976|Bacteroidetes	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
LZS2_k127_8918415_1	330214.NIDE3156	3.742e-129	424.0	COG1476@1|root,COG1910@1|root,COG1476@2|Bacteria,COG1910@2|Bacteria,3J13A@40117|Nitrospirae	40117|Nitrospirae	K	PBP superfamily domain	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
LZS2_k127_8918415_6	857087.Metme_2089	1.922e-75	274.0	COG3637@1|root,COG3637@2|Bacteria,1R64D@1224|Proteobacteria,1S325@1236|Gammaproteobacteria,1XDN4@135618|Methylococcales	135618|Methylococcales	M	Alginate export	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_exp
LZS2_k127_8918415_5	652103.Rpdx1_4892	1.76e-75	260.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,3JU6M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
LZS2_k127_8918415_3	1131269.AQVV01000002_gene1264	5.996e-87	292.0	COG4149@1|root,COG4149@2|Bacteria	2|Bacteria	P	molybdate abc transporter	modB	-	-	ko:K02018,ko:K15496	ko02010,map02010	M00189,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5,3.A.1.8	-	-	BPD_transp_1
LZS2_k127_8918415_2	1163617.SCD_n01056	2.126e-102	346.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
LZS2_k127_8918415_7	330214.NIDE3144	3.2e-71	244.0	COG1974@1|root,COG1974@2|Bacteria,3J1C0@40117|Nitrospirae	40117|Nitrospirae	K	Represses a number of genes involved in the response to DNA damage (SOS response)	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
LZS2_k127_8918415_4	1304885.AUEY01000096_gene2839	8.477e-84	282.0	COG1404@1|root,COG2304@1|root,COG2911@1|root,COG3897@1|root,COG5434@1|root,COG1404@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG3897@2|Bacteria,COG5434@2|Bacteria,1P8N9@1224|Proteobacteria,43DXZ@68525|delta/epsilon subdivisions,2X72D@28221|Deltaproteobacteria,2MNHJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
LZS2_k127_962349_0	330214.NIDE0694	1.045e-178	571.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,3J117@40117|Nitrospirae	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HATPase_c,HisKA
LZS2_k127_962349_1	643648.Slip_1894	1.361e-47	177.0	28JE3@1|root,2Z98B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
LZS2_k127_97152_1	330214.NIDE1676	2.255e-16	79.0	COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae	40117|Nitrospirae	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
LZS2_k127_97152_0	1125863.JAFN01000001_gene360	1.281e-90	312.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42UBK@68525|delta/epsilon subdivisions,2WQU5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
## 3223 queries scanned
## Total time (seconds): 247.0537874698639
## Rate: 13.05 q/s