## Fri Nov 15 11:56:54 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin13/LZS_3_bin.110.fa -m mmseqs --itype genome -o LZS_3_bin.110 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/LZS_3_bin.110 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
LZS3_k127_111140_1	941824.TCEL_00932	1.622e-180	586.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,36EUE@31979|Clostridiaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
LZS3_k127_111140_4	1033743.CAES01000086_gene3000	6.893e-19	89.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,26ZAP@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
LZS3_k127_111140_0	926692.AZYG01000040_gene1419	1.097e-182	584.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3WA7Q@53433|Halanaerobiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
LZS3_k127_111140_3	1122939.ATUD01000001_gene105	4.888e-55	200.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4CQGA@84995|Rubrobacteria	84995|Rubrobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
LZS3_k127_111140_2	515635.Dtur_1167	1.377e-65	227.0	COG0064@1|root,COG0064@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.12,6.3.5.6,6.3.5.7	ko:K01876,ko:K02434	ko00970,ko01100,map00970,map01100	M00359,M00360	R03905,R04212,R05577	RC00010,RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GatB_N,GatB_Yqey
LZS3_k127_1216270_0	857293.CAAU_1634	1.527e-152	495.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,36DC4@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
LZS3_k127_1216270_1	243164.DET0580	7.57e-43	168.0	COG1381@1|root,COG1381@2|Bacteria,2G6N7@200795|Chloroflexi,34CSZ@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
LZS3_k127_1216270_2	886293.Sinac_6338	2.484e-15	78.0	COG1207@1|root,COG1207@2|Bacteria,2IXXB@203682|Planctomycetes	203682|Planctomycetes	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
LZS3_k127_1246859_4	616991.JPOO01000001_gene2813	0.0003634	47.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1HZ97@117743|Flavobacteriia,23H64@178469|Arenibacter	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
LZS3_k127_1246859_2	1434325.AZQN01000011_gene3796	8.523e-36	140.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,47PB4@768503|Cytophagia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
LZS3_k127_1246859_1	386456.JQKN01000004_gene198	6.489e-47	171.0	COG0229@1|root,arCOG02815@2157|Archaea,2XXVK@28890|Euryarchaeota	28890|Euryarchaeota	O	COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
LZS3_k127_1246859_0	1304888.ATWF01000001_gene883	3.654e-50	189.0	COG1409@1|root,COG1409@2|Bacteria,2GG4Q@200930|Deferribacteres	200930|Deferribacteres	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
LZS3_k127_1246859_3	1416759.AYMR01000009_gene2849	6.598e-19	89.0	COG1937@1|root,COG1937@2|Bacteria,2HSPC@201174|Actinobacteria,4FPPM@85023|Microbacteriaceae	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
LZS3_k127_1259004_1	1122172.KB890272_gene89	9.287e-76	268.0	2EZ1V@1|root,33S8A@2|Bacteria	2|Bacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
LZS3_k127_1259004_2	717231.Flexsi_0370	5.182e-53	196.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	wcaE	-	-	ko:K13683	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
LZS3_k127_1259004_0	203124.Tery_3753	3.095e-125	417.0	COG0438@1|root,COG0500@1|root,COG1215@1|root,COG1511@1|root,COG2227@1|root,COG3914@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,COG1511@2|Bacteria,COG2226@2|Bacteria,COG2227@2|Bacteria,COG3914@2|Bacteria,1FZUY@1117|Cyanobacteria,1H72J@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_23
LZS3_k127_1476630_9	604354.TSIB_0956	2.647e-07	61.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXMZ@28890|Euryarchaeota,245B2@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
LZS3_k127_1476630_8	744980.TRICHSKD4_1418	1.291e-08	61.0	2C9Y3@1|root,33JDQ@2|Bacteria,1NQEK@1224|Proteobacteria,2UUJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1476630_1	572479.Hprae_0965	9.934e-63	225.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,3WABN@53433|Halanaerobiales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
LZS3_k127_1476630_4	314292.VAS14_11519	5.793e-20	97.0	COG1434@1|root,COG1434@2|Bacteria,1N4TG@1224|Proteobacteria,1RSJ5@1236|Gammaproteobacteria,1XWHV@135623|Vibrionales	135623|Vibrionales	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
LZS3_k127_1476630_7	986075.CathTA2_2484	2.695e-12	74.0	COG3327@1|root,COG3327@2|Bacteria,1TRBU@1239|Firmicutes,4HCP9@91061|Bacilli	91061|Bacilli	K	Phenylacetic acid degradation operon negative regulatory protein PaaX	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
LZS3_k127_1476630_6	1254432.SCE1572_12720	1.853e-12	82.0	COG0613@1|root,COG0613@2|Bacteria,1PBDI@1224|Proteobacteria,433WS@68525|delta/epsilon subdivisions,2X3XD@28221|Deltaproteobacteria,2YXFZ@29|Myxococcales	28221|Deltaproteobacteria	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1476630_0	1120933.ATUY01000004_gene991	5.005e-184	601.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4D42B@85005|Actinomycetales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
LZS3_k127_1476630_3	1123368.AUIS01000001_gene1866	1.032e-24	107.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,1SIID@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
LZS3_k127_1476630_5	639282.DEFDS_0358	1.965e-17	85.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
LZS3_k127_1476630_2	525904.Tter_0567	1.579e-28	123.0	COG3103@1|root,COG3764@1|root,COG3103@2|Bacteria,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	ylcC	-	3.4.22.70,3.5.1.104	ko:K07284,ko:K22278	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
LZS3_k127_1534243_4	1343158.SACS_0940	0.0006156	49.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,2JR6D@204441|Rhodospirillales	204441|Rhodospirillales	V	COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
LZS3_k127_1534243_0	864702.OsccyDRAFT_1512	5.407e-84	295.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS3_k127_1534243_3	5551.XP_003231392.1	0.0002017	53.0	2EKFI@1|root,2SQCG@2759|Eukaryota,3A4YF@33154|Opisthokonta,3P48R@4751|Fungi,3QVWP@4890|Ascomycota,20ED5@147545|Eurotiomycetes,3B0IJ@33183|Onygenales,3FYTR@34384|Arthrodermataceae	4751|Fungi	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
LZS3_k127_1534243_1	311403.Arad_2626	3.991e-10	68.0	COG3340@1|root,COG3340@2|Bacteria,1PSH0@1224|Proteobacteria,2UXQ3@28211|Alphaproteobacteria,4BIU9@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Peptidase family S51	-	-	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
LZS3_k127_1534243_2	909663.KI867150_gene818	4.392e-05	51.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
LZS3_k127_1547493_7	349520.PPE_04391	2.716e-13	83.0	COG1361@1|root,COG1361@2|Bacteria,1UQ5B@1239|Firmicutes,4IPKB@91061|Bacilli	91061|Bacilli	M	conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
LZS3_k127_1547493_8	1236976.JCM16418_4613	3.468e-13	83.0	COG1361@1|root,COG1361@2|Bacteria,1V4V3@1239|Firmicutes,4HT0D@91061|Bacilli,26QKX@186822|Paenibacillaceae	91061|Bacilli	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
LZS3_k127_1547493_1	88036.EFJ06863	6.708e-85	292.0	COG0216@1|root,KOG2726@2759|Eukaryota,37HPK@33090|Viridiplantae,3GG2E@35493|Streptophyta	33090|Viridiplantae	J	peptide chain release factor	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006412,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009657,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
LZS3_k127_1547493_9	456442.Mboo_1215	1.854e-10	70.0	arCOG12694@1|root,arCOG12694@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1547493_10	1125863.JAFN01000001_gene1038	1.571e-06	55.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,42TGQ@68525|delta/epsilon subdivisions,2WQ6R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
LZS3_k127_1547493_3	650150.ERH_1700	2.677e-40	156.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,3VQBC@526524|Erysipelotrichia	526524|Erysipelotrichia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
LZS3_k127_1547493_4	1382315.JPOI01000001_gene764	8.124e-40	158.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4HAK4@91061|Bacilli,1WFWF@129337|Geobacillus	91061|Bacilli	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
LZS3_k127_1547493_5	1347392.CCEZ01000044_gene602	6.184e-36	143.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,36I5W@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
LZS3_k127_1547493_6	653733.Selin_1944	1.395e-33	136.0	COG0222@1|root,COG0222@2|Bacteria	2|Bacteria	J	mitochondrial gene expression	rplL	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0046983,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
LZS3_k127_1547493_0	273068.TTE1183	5.488e-108	361.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,42EMN@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
LZS3_k127_1547493_11	1385512.N784_03245	1.106e-05	55.0	COG3327@1|root,COG3327@2|Bacteria,1TRBU@1239|Firmicutes,4HCP9@91061|Bacilli,2YA5R@289201|Pontibacillus	91061|Bacilli	K	PaaX family transcrtiptional regulator	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
LZS3_k127_1547493_2	153948.NAL212_2601	4.691e-42	158.0	COG1943@1|root,COG1943@2|Bacteria,1QKQ2@1224|Proteobacteria,2WC8F@28216|Betaproteobacteria,374G1@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
LZS3_k127_1569392_4	720554.Clocl_2456	6.823e-94	322.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,3WG8A@541000|Ruminococcaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
LZS3_k127_1569392_7	858215.Thexy_0424	4.127e-43	168.0	COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,42FEU@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid	tarA	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,PS_pyruv_trans
LZS3_k127_1569392_2	351627.Csac_2568	2.386e-102	345.0	COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,24ARN@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_1569392_6	635013.TherJR_2843	1.321e-47	184.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,262C0@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
LZS3_k127_1569392_1	1382356.JQMP01000003_gene1994	5.145e-113	374.0	COG1077@1|root,COG1077@2|Bacteria,2G5KV@200795|Chloroflexi,27Y3P@189775|Thermomicrobia	189775|Thermomicrobia	D	Cell division protein FtsA	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
LZS3_k127_1569392_3	373903.Hore_17770	2.065e-99	338.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,3WABW@53433|Halanaerobiales	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
LZS3_k127_1569392_0	1122169.AREN01000004_gene515	5.283e-132	439.0	COG0507@1|root,COG0507@2|Bacteria,1QCFP@1224|Proteobacteria,1S1GX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	helicase	pif1	-	-	-	-	-	-	-	-	-	-	-	HTH_40,PIF1
LZS3_k127_1569392_5	717231.Flexsi_1920	7.592e-59	211.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
LZS3_k127_168592_1	1444712.BN1013_00905	3.172e-43	171.0	COG0770@1|root,COG0770@2|Bacteria,2JFWE@204428|Chlamydiae	204428|Chlamydiae	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
LZS3_k127_168592_0	926561.KB900617_gene1681	2.64e-92	324.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3WAHA@53433|Halanaerobiales	186801|Clostridia	M	Penicillin-binding protein dimerisation domain	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
LZS3_k127_168592_2	1235279.C772_00623	5.547e-41	155.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,4HH23@91061|Bacilli,26EU6@186818|Planococcaceae	91061|Bacilli	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
LZS3_k127_1863142_0	635013.TherJR_0288	0.0	1061.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,25ZXZ@186807|Peptococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
LZS3_k127_1863142_2	1209072.ALBT01000044_gene2515	7.988e-05	56.0	COG2273@1|root,COG2273@2|Bacteria,1NHMA@1224|Proteobacteria,1SYWF@1236|Gammaproteobacteria,1FFSP@10|Cellvibrio	1236|Gammaproteobacteria	G	Coagulation factor 5/8 C-terminal domain, discoidin domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,F5_F8_type_C,Glyco_hydro_16
LZS3_k127_1863142_3	28583.AMAG_00953T0	0.0009216	50.0	COG0681@1|root,KOG0171@2759|Eukaryota,395CK@33154|Opisthokonta,3P2HD@4751|Fungi	4751|Fungi	O	mitochondrial inner membrane protease subunit	-	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006465,GO:0006508,GO:0006518,GO:0006605,GO:0006626,GO:0006627,GO:0006807,GO:0006810,GO:0006839,GO:0006886,GO:0006996,GO:0007005,GO:0008104,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0009987,GO:0010467,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0019866,GO:0022607,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0033036,GO:0033108,GO:0033365,GO:0034613,GO:0034622,GO:0034641,GO:0034982,GO:0042720,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0065003,GO:0070011,GO:0070585,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072655,GO:0098796,GO:0098798,GO:0098800,GO:0140096,GO:1901564	-	ko:K09647	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03029	-	-	-	Peptidase_S24,Peptidase_S26
LZS3_k127_1863142_1	1034347.CAHJ01000027_gene3859	1.279e-32	132.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,4HGZX@91061|Bacilli,1ZFJ0@1386|Bacillus	91061|Bacilli	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070930,GO:0071704,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
LZS3_k127_1913253_1	525904.Tter_0596	2.695e-09	68.0	COG0202@1|root,COG0568@1|root,COG0202@2|Bacteria,COG0568@2|Bacteria	2|Bacteria	K	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6,2.7.7.7	ko:K02342,ko:K02909,ko:K03040,ko:K03046,ko:K03086	ko00230,ko00240,ko01100,ko03010,ko03020,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03010,map03020,map03030,map03430,map03440	M00178,M00183,M00260	R00375,R00376,R00377,R00378,R00435,R00441,R00442,R00443	RC02795	br01610,br01611,ko00000,ko00001,ko00002,ko01000,ko03011,ko03021,ko03032,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L,Sigma70_r4
LZS3_k127_1913253_0	1047013.AQSP01000118_gene1252	8.347e-133	461.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2094782_6	1523503.JPMY01000010_gene2676	6.786e-14	81.0	COG2972@1|root,COG5001@1|root,COG2972@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K21023	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	EAL,GAF,GGDEF,HAMP,PAS_3,PAS_4,PAS_7,PAS_9
LZS3_k127_2094782_7	1009370.ALO_07813	5.679e-13	79.0	COG1146@1|root,COG1146@2|Bacteria,1VHE7@1239|Firmicutes	1239|Firmicutes	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
LZS3_k127_2094782_4	1449126.JQKL01000060_gene1871	3.777e-30	130.0	COG1014@1|root,COG1014@2|Bacteria,1TPNK@1239|Firmicutes,24CCV@186801|Clostridia	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	oorC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
LZS3_k127_2094782_0	1121472.AQWN01000007_gene1094	1.377e-85	289.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,26129@186807|Peptococcaceae	186801|Clostridia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
LZS3_k127_2094782_1	264732.Moth_0033	1.076e-84	292.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,42FKU@68295|Thermoanaerobacterales	186801|Clostridia	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
LZS3_k127_2094782_2	1123399.AQVE01000024_gene2791	2.625e-56	210.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,460BN@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
LZS3_k127_2094782_3	999425.HMPREF9186_00080	3.811e-42	161.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,4HAG3@91061|Bacilli	91061|Bacilli	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	PTAC
LZS3_k127_2094782_5	748727.CLJU_c39120	9.505e-15	83.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,36EXB@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
LZS3_k127_2176285_12	1519439.JPJG01000081_gene476	0.0006156	49.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,2N7MX@216572|Oscillospiraceae	186801|Clostridia	S	Trp repressor protein	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
LZS3_k127_2176285_3	333138.LQ50_11045	2.05e-50	192.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,4HA0W@91061|Bacilli,1ZC8V@1386|Bacillus	91061|Bacilli	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
LZS3_k127_2176285_2	243164.DET1227	6.296e-70	250.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi,34CUN@301297|Dehalococcoidia	301297|Dehalococcoidia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
LZS3_k127_2176285_0	479434.Sthe_0001	3.319e-115	386.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi,27XP6@189775|Thermomicrobia	189775|Thermomicrobia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
LZS3_k127_2176285_11	1504319.GM45_6230	2.613e-10	61.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,3UXMF@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	J	Ribosomal protein L34	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
LZS3_k127_2176285_13	536227.CcarbDRAFT_3059	0.0007031	47.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,36KNM@31979|Clostridiaceae	186801|Clostridia	T	Belongs to the anti-sigma-factor antagonist family	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
LZS3_k127_2176285_10	459495.SPLC1_S102410	1.368e-10	67.0	COG0594@1|root,COG0594@2|Bacteria,1G7Z7@1117|Cyanobacteria,1HC5M@1150|Oscillatoriales	1117|Cyanobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
LZS3_k127_2176285_7	639282.DEFDS_0348	2.656e-20	93.0	COG0759@1|root,COG0759@2|Bacteria,2GG13@200930|Deferribacteres	200930|Deferribacteres	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
LZS3_k127_2176285_5	871963.Desdi_3533	1.336e-32	139.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,261MW@186807|Peptococcaceae	186801|Clostridia	U	Membrane protein insertase, YidC Oxa1 family	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
LZS3_k127_2176285_4	997884.HMPREF1068_00185	2.584e-34	134.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,2FU1D@200643|Bacteroidia	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_2176285_9	1313421.JHBV01000025_gene1056	7.352e-11	75.0	COG1520@1|root,COG3386@1|root,COG1520@2|Bacteria,COG3386@2|Bacteria,4NMUS@976|Bacteroidetes	976|Bacteroidetes	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2176285_6	485916.Dtox_4366	2.247e-20	96.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,260UK@186807|Peptococcaceae	186801|Clostridia	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
LZS3_k127_2176285_8	886293.Sinac_0796	1.211e-15	82.0	COG0614@1|root,COG0614@2|Bacteria,2J075@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_2176285_1	717231.Flexsi_1222	2.756e-111	379.0	COG2804@1|root,COG2804@2|Bacteria,2GEP7@200930|Deferribacteres	200930|Deferribacteres	NU	General secretory system II protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
LZS3_k127_2205253_3	743299.Acife_3238	9.413e-27	117.0	COG1216@1|root,COG2230@1|root,COG1216@2|Bacteria,COG2230@2|Bacteria,1MX5Z@1224|Proteobacteria,1RMDY@1236|Gammaproteobacteria,2NBX8@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_tranf_2_3,Glycos_transf_2,Methyltransf_23
LZS3_k127_2205253_5	1236973.JCM9157_3073	1.56e-14	84.0	COG1216@1|root,COG1216@2|Bacteria,1VATJ@1239|Firmicutes,4HCW0@91061|Bacilli,1ZFI5@1386|Bacillus	91061|Bacilli	S	COG0463 Glycosyltransferases involved in cell wall biogenesis	epsJ	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K19425,ko:K19427	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
LZS3_k127_2205253_2	868131.MSWAN_1337	3.403e-42	163.0	COG0500@1|root,arCOG04989@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
LZS3_k127_2205253_0	1400525.JNIU01000001_gene871	5.601e-67	240.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	tagX	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	DUF3880,Glycos_transf_2,Methyltransf_23
LZS3_k127_2205253_1	1400525.JNIU01000001_gene883	3.255e-54	205.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
LZS3_k127_2323529_1	1348657.M622_18465	0.0007249	51.0	COG0726@1|root,COG2931@1|root,COG3291@1|root,COG5295@1|root,COG0726@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2W2SX@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2323529_0	880072.Desac_0909	7.431e-91	312.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria,2MQYH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_24
LZS3_k127_2341080_1	178306.PAE3025	1.007e-45	178.0	COG0449@1|root,arCOG00057@2157|Archaea,2XPJW@28889|Crenarchaeota	28889|Crenarchaeota	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
LZS3_k127_2341080_0	309801.trd_A0017	6.645e-173	556.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,27Y2X@189775|Thermomicrobia	189775|Thermomicrobia	O	Magnesium chelatase, subunit ChlI	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
LZS3_k127_2341080_3	1128421.JAGA01000002_gene552	3.86e-06	51.0	COG1314@1|root,COG1314@2|Bacteria,2NS1U@2323|unclassified Bacteria	2|Bacteria	U	Preprotein translocase SecG subunit	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
LZS3_k127_2341080_2	827.JFJK01000001_gene778	1.478e-21	109.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2YN87@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Abc transporter	nikZ	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
LZS3_k127_2450251_2	1380408.AVGH01000024_gene1640	3.95e-05	56.0	COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,4HBRS@91061|Bacilli,21V3G@150247|Anoxybacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
LZS3_k127_2450251_1	313606.M23134_05196	5.006e-33	130.0	2B1XW@1|root,31UE7@2|Bacteria,4NY8Q@976|Bacteroidetes,47W4P@768503|Cytophagia	976|Bacteroidetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_2450251_0	485913.Krac_5164	2.074e-60	219.0	COG1210@1|root,COG1210@2|Bacteria,2G6XV@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
LZS3_k127_2720487_3	1347086.CCBA010000023_gene2067	3.448e-16	83.0	COG1051@1|root,COG1051@2|Bacteria,1V6ZQ@1239|Firmicutes,4HIQM@91061|Bacilli,1ZIC1@1386|Bacillus	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
LZS3_k127_2720487_0	1295642.H839_05814	5.94e-97	362.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,4HBZE@91061|Bacilli,1WH6H@129337|Geobacillus	91061|Bacilli	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-TG,RHS_repeat
LZS3_k127_2720487_4	573061.Clocel_3603	4.35e-11	78.0	2FDF2@1|root,345GQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2720487_1	1298920.KI911353_gene3885	6.413e-26	110.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,2211R@1506553|Lachnoclostridium	186801|Clostridia	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
LZS3_k127_2720487_2	608506.COB47_0305	5.97e-20	93.0	2EUD4@1|root,33MVH@2|Bacteria,1VPDY@1239|Firmicutes,254NJ@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF2019)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2019
LZS3_k127_2720487_6	204669.Acid345_3792	8.272e-08	60.0	COG1004@1|root,COG1004@2|Bacteria,3Y3JZ@57723|Acidobacteria,2JKW4@204432|Acidobacteriia	204432|Acidobacteriia	M	UDP binding domain	-	-	1.1.1.132	ko:K00066	ko00051,ko00520,ko02020,map00051,map00520,map02020	-	R00880	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
LZS3_k127_2720487_7	641107.CDLVIII_2670	9.953e-08	61.0	COG1418@1|root,COG1418@2|Bacteria,1V2RJ@1239|Firmicutes,25B26@186801|Clostridia,36WDH@31979|Clostridiaceae	186801|Clostridia	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
LZS3_k127_2720487_5	171693.BN988_03393	4.805e-11	64.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,23JTS@182709|Oceanobacillus	91061|Bacilli	T	PAS domain	vicK	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9
LZS3_k127_2720487_8	479437.Elen_2651	2.085e-05	49.0	COG0641@1|root,COG0641@2|Bacteria,2I6AC@201174|Actinobacteria,4CVIZ@84998|Coriobacteriia	84998|Coriobacteriia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
LZS3_k127_2891219_18	324602.Caur_3675	2.086e-05	53.0	COG1238@1|root,COG1238@2|Bacteria,2G932@200795|Chloroflexi,375X7@32061|Chloroflexia	32061|Chloroflexia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
LZS3_k127_2891219_3	536232.CLM_1691	2.281e-78	272.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,36E4H@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
LZS3_k127_2891219_1	1176165.CAJD01000012_gene695	1.712e-87	308.0	COG1215@1|root,COG1215@2|Bacteria,2IK1V@201174|Actinobacteria,4F9BY@85019|Brevibacteriaceae	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2891219_10	411467.BACCAP_01292	1.661e-14	79.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
LZS3_k127_2891219_6	1267533.KB906737_gene1988	3.718e-44	181.0	COG1807@1|root,COG1807@2|Bacteria,3Y710@57723|Acidobacteria,2JKXM@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
LZS3_k127_2891219_5	1499967.BAYZ01000017_gene6259	1.826e-56	205.0	COG1215@1|root,COG1215@2|Bacteria,2NPW4@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS3_k127_2891219_15	1122599.AUGR01000027_gene1270	2.219e-06	50.0	2AWWV@1|root,31NUD@2|Bacteria,1QPF3@1224|Proteobacteria,1SJ55@1236|Gammaproteobacteria,1XQNS@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2891219_14	762903.Pedsa_2303	4.359e-07	65.0	COG2911@1|root,COG4733@1|root,COG2911@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
LZS3_k127_2891219_8	435590.BVU_0327	2.499e-26	112.0	2DMPS@1|root,32SXU@2|Bacteria,4NTIT@976|Bacteroidetes,2G0J8@200643|Bacteroidia,4AR0W@815|Bacteroidaceae	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_2891219_11	1379698.RBG1_1C00001G1691	2.846e-08	65.0	COG3121@1|root,COG3121@2|Bacteria	2|Bacteria	NU	pilus organization	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	ASH,DUF3324,DUF916
LZS3_k127_2891219_16	1463821.JOGR01000002_gene472	7.827e-06	59.0	COG2755@1|root,COG3534@1|root,COG2755@2|Bacteria,COG3534@2|Bacteria,2GK5H@201174|Actinobacteria	201174|Actinobacteria	E	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
LZS3_k127_2891219_13	1463861.JNXE01000042_gene6787	1.432e-07	63.0	COG1361@1|root,COG1361@2|Bacteria,2HZGC@201174|Actinobacteria	201174|Actinobacteria	M	Bacterial protein of unknown function (DUF916)	-	-	-	-	-	-	-	-	-	-	-	-	DUF916
LZS3_k127_2891219_19	1034943.BN1094_00290	9.995e-05	54.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1JFDY@118969|Legionellales	118969|Legionellales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	rtxA2_1	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,HemolysinCabind
LZS3_k127_2891219_12	1123274.KB899436_gene1284	5.488e-08	66.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
LZS3_k127_2891219_0	1031288.AXAA01000001_gene2325	2.463e-153	499.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,36DXD@31979|Clostridiaceae	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
LZS3_k127_2891219_4	1121430.JMLG01000001_gene2103	1.125e-77	268.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
LZS3_k127_2891219_9	644966.Tmar_0103	5.389e-23	100.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,3WCKQ@538999|Clostridiales incertae sedis	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
LZS3_k127_2891219_2	1499967.BAYZ01000177_gene5729	7.835e-79	273.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
LZS3_k127_2891219_17	1246459.KB898369_gene891	9.475e-06	49.0	2EPV2@1|root,33HFI@2|Bacteria,1P4JW@1224|Proteobacteria,2UYBR@28211|Alphaproteobacteria,4BH9U@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2891219_7	525904.Tter_1235	1.267e-38	157.0	COG0628@1|root,COG0628@2|Bacteria,2NPIB@2323|unclassified Bacteria	2|Bacteria	S	AI-2E family transporter	yueF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
LZS3_k127_2941271_24	1115512.EH105704_31_00010	0.0002895	52.0	COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,VCBS
LZS3_k127_2941271_16	319003.Bra1253DRAFT_04908	3.255e-15	77.0	COG2827@1|root,COG2827@2|Bacteria,1N04N@1224|Proteobacteria,2UCN4@28211|Alphaproteobacteria,3K0D8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	GIY-YIG catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
LZS3_k127_2941271_14	1121887.AUDK01000005_gene3161	4.776e-19	89.0	COG1476@1|root,COG1476@2|Bacteria,4PNJ4@976|Bacteroidetes	976|Bacteroidetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
LZS3_k127_2941271_1	523791.Kkor_1707	2.835e-108	369.0	COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria,1XJ7Z@135619|Oceanospirillales	135619|Oceanospirillales	H	Methyltransferase	-	-	2.1.1.37	ko:K00558	ko00270,ko01100,ko05206,map00270,map01100,map05206	M00035	R04858	RC00003,RC00332	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_methylase
LZS3_k127_2941271_6	877411.JMMA01000002_gene2079	1.595e-40	168.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,3WHGN@541000|Ruminococcaceae	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
LZS3_k127_2941271_21	883.DvMF_3073	6.289e-08	65.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42R36@68525|delta/epsilon subdivisions,2WU0Z@28221|Deltaproteobacteria,2MG78@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Single cache domain 3	frzCD	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,PAS_4,PAS_9,dCache_1,sCache_3_2,sCache_3_3
LZS3_k127_2941271_22	1157640.AQWO01000007_gene3565	7.823e-08	66.0	COG3391@1|root,COG3391@2|Bacteria,2H4SV@201174|Actinobacteria	201174|Actinobacteria	MU	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5
LZS3_k127_2941271_8	1459636.NTE_02664	3.491e-30	139.0	COG1409@1|root,arCOG06534@1|root,arCOG07781@1|root,arCOG09729@1|root,arCOG06534@2157|Archaea,arCOG07781@2157|Archaea,arCOG09729@2157|Archaea,arCOG11020@2157|Archaea	2157|Archaea	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,CHB_HEX_C_1,He_PIG,PKD,Polysacc_deac_1
LZS3_k127_2941271_13	1303518.CCALI_00427	2.802e-21	98.0	COG0745@1|root,COG0745@2|Bacteria	1303518.CCALI_00427|-	T	phosphorelay signal transduction system	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	-
LZS3_k127_2941271_7	313624.NSP_34990	8.941e-31	130.0	COG0784@1|root,COG1352@1|root,COG2201@1|root,COG5002@1|root,COG0784@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,1GPYK@1117|Cyanobacteria,1HUA6@1161|Nostocales	1117|Cyanobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
LZS3_k127_2941271_3	1232410.KI421420_gene3143	3.223e-56	216.0	COG4936@1|root,COG5002@1|root,COG4936@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WM5B@28221|Deltaproteobacteria,43U8X@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
LZS3_k127_2941271_10	1219084.AP014508_gene1338	9.877e-25	108.0	COG0745@1|root,COG0745@2|Bacteria,2GDAM@200918|Thermotogae	200918|Thermotogae	T	PFAM response regulator receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
LZS3_k127_2941271_20	1499689.CCNN01000007_gene1095	2.209e-08	60.0	COG4980@1|root,COG4980@2|Bacteria,1VK4M@1239|Firmicutes,24VID@186801|Clostridia,36PAB@31979|Clostridiaceae	186801|Clostridia	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
LZS3_k127_2941271_11	580327.Tthe_2016	4.685e-22	99.0	COG1342@1|root,COG1342@2|Bacteria,1V5RE@1239|Firmicutes,25CFP@186801|Clostridia,42GP4@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the UPF0251 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
LZS3_k127_2941271_23	370438.PTH_0583	0.0001879	47.0	2BC4B@1|root,325P4@2|Bacteria,1URPN@1239|Firmicutes,259K8@186801|Clostridia,26385@186807|Peptococcaceae	186801|Clostridia	S	Family of unknown function (DUF5320)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5320
LZS3_k127_2941271_19	3218.PP1S30_232V6.1	5.965e-09	65.0	COG0500@1|root,2S237@2759|Eukaryota,380UD@33090|Viridiplantae	33090|Viridiplantae	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
LZS3_k127_2941271_18	1343739.PAP_06600	8.183e-10	68.0	COG1476@1|root,arCOG01864@2157|Archaea,2XZS8@28890|Euryarchaeota,244GH@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
LZS3_k127_2941271_12	383372.Rcas_4342	1.151e-21	104.0	COG0071@1|root,COG0071@2|Bacteria,2G71M@200795|Chloroflexi,375U7@32061|Chloroflexia	32061|Chloroflexia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
LZS3_k127_2941271_9	1321773.HMPREF9069_00053	2.941e-28	123.0	COG0125@1|root,COG0125@2|Bacteria,2GNTI@201174|Actinobacteria,4CVPV@84998|Coriobacteriia	84998|Coriobacteriia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
LZS3_k127_2941271_5	255470.cbdbA364	1.541e-40	156.0	COG0237@1|root,COG0237@2|Bacteria,2GARS@200795|Chloroflexi,34D6Q@301297|Dehalococcoidia	301297|Dehalococcoidia	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
LZS3_k127_2941271_2	545694.TREPR_2477	9.855e-71	243.0	COG2131@1|root,COG2131@2|Bacteria,2J6UR@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
LZS3_k127_2941271_17	1120968.AUBX01000010_gene952	8.054e-10	63.0	COG2827@1|root,COG2827@2|Bacteria,4NZEA@976|Bacteroidetes	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
LZS3_k127_2941271_0	555079.Toce_1405	1.395e-206	657.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,42EQA@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
LZS3_k127_2941271_4	1121335.Clst_0840	7.217e-44	164.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,3WGSQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
LZS3_k127_3025937_1	880073.Calab_0862	1.676e-65	236.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
LZS3_k127_3025937_5	1046627.BZARG_963	4.605e-18	89.0	COG0614@1|root,COG0614@2|Bacteria,4NS4Q@976|Bacteroidetes,1I3MV@117743|Flavobacteriia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3025937_2	1122947.FR7_3256	4.083e-56	208.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4H2QQ@909932|Negativicutes	909932|Negativicutes	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
LZS3_k127_3025937_6	338966.Ppro_0028	3.58e-13	78.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2WKAF@28221|Deltaproteobacteria,43TN9@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3178	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
LZS3_k127_3025937_0	1209989.TepiRe1_1291	3.391e-90	312.0	COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,42F9I@68295|Thermoanaerobacterales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
LZS3_k127_3025937_3	309801.trd_0649	2.792e-53	198.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi,27Y1D@189775|Thermomicrobia	189775|Thermomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
LZS3_k127_3025937_4	1236541.BALL01000001_gene113	4.706e-48	181.0	COG4185@1|root,COG4185@2|Bacteria,1R9KV@1224|Proteobacteria,1RRF7@1236|Gammaproteobacteria,2QDVQ@267890|Shewanellaceae	1236|Gammaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
LZS3_k127_3107374_3	641143.HMPREF9331_00572	3.707e-49	185.0	COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,1HWKX@117743|Flavobacteriia,1ESYX@1016|Capnocytophaga	976|Bacteroidetes	S	Glycosyltransferase like family	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
LZS3_k127_3107374_1	1262449.CP6013_3780	4.342e-89	306.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,36E4U@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
LZS3_k127_3107374_4	868131.MSWAN_0936	2.531e-32	142.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota,23PDF@183925|Methanobacteria	183925|Methanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
LZS3_k127_3107374_6	1122239.AULS01000022_gene2443	2.116e-09	69.0	COG3266@1|root,COG3807@1|root,COG5479@1|root,COG3266@2|Bacteria,COG3807@2|Bacteria,COG5479@2|Bacteria,2HYIN@201174|Actinobacteria,4FMTD@85023|Microbacteriaceae	201174|Actinobacteria	M	Belongs to the 5'-nucleotidase family	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,SH3_3,SH3_4,VCBS
LZS3_k127_3107374_5	1211817.CCAT010000083_gene1671	1.001e-10	74.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia,36ERI@31979|Clostridiaceae	186801|Clostridia	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
LZS3_k127_3107374_7	383372.Rcas_2722	2.589e-06	59.0	COG3307@1|root,COG3307@2|Bacteria,2G9UT@200795|Chloroflexi,3777N@32061|Chloroflexia	32061|Chloroflexia	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
LZS3_k127_3107374_2	941824.TCEL_00115	1.211e-50	196.0	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,36DY2@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_3107374_0	903814.ELI_0666	9.961e-215	686.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,25V7G@186806|Eubacteriaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
LZS3_k127_3107374_8	580331.Thit_2320	1.271e-05	50.0	2DNSU@1|root,32YYQ@2|Bacteria,1VIFP@1239|Firmicutes,24SYY@186801|Clostridia,42H8H@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF3006)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3006
LZS3_k127_3159844_0	667014.Thein_1029	4.221e-20	102.0	COG0760@1|root,COG0760@2|Bacteria,2GHMC@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
LZS3_k127_3159844_4	42256.RradSPS_0047	1.968e-05	56.0	2DFV5@1|root,2ZT9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3159844_2	1121938.AUDY01000012_gene3673	3.388e-07	51.0	2A8J0@1|root,30XM8@2|Bacteria,1V5ZB@1239|Firmicutes,4HHFV@91061|Bacilli,3NEXA@45667|Halobacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3159844_6	1070774.J07HN4v3_03050	0.0004646	47.0	COG0111@1|root,COG2827@1|root,arCOG01754@2157|Archaea,arCOG04722@2157|Archaea,2XU9V@28890|Euryarchaeota,23S5I@183963|Halobacteria	183963|Halobacteria	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA1	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
LZS3_k127_3159844_3	1265505.ATUG01000001_gene4157	4.811e-06	57.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2MIYB@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
LZS3_k127_3159844_5	644281.MFS40622_0272	2.828e-05	54.0	COG0207@1|root,arCOG03214@2157|Archaea,2XTCY@28890|Euryarchaeota,23QQM@183939|Methanococci	183939|Methanococci	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
LZS3_k127_3159844_1	273057.SSO0432	6.162e-17	85.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
LZS3_k127_3163999_7	349161.Dred_1947	5.15e-75	267.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
LZS3_k127_3163999_10	397948.Cmaq_0429	8.178e-61	216.0	COG0105@1|root,arCOG04313@2157|Archaea,2XQEV@28889|Crenarchaeota	28889|Crenarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
LZS3_k127_3163999_18	65393.PCC7424_4808	2.479e-21	98.0	COG0614@1|root,COG0614@2|Bacteria,1GJEH@1117|Cyanobacteria,3KKIH@43988|Cyanothece	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3163999_9	1280706.AUJE01000025_gene1167	8.081e-61	223.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H2U9@909932|Negativicutes	909932|Negativicutes	M	Glycosyltransferase, group 4 family	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
LZS3_k127_3163999_27	485913.Krac_12036	2.817e-11	70.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	PASTA,bPH_2
LZS3_k127_3163999_0	1121430.JMLG01000005_gene747	2.84e-313	998.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
LZS3_k127_3163999_21	186497.PF1027	2.254e-19	102.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
LZS3_k127_3163999_17	1122212.AULO01000010_gene67	6.982e-27	112.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1XKKY@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
LZS3_k127_3163999_15	1329516.JPST01000007_gene1510	3.814e-34	137.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,27C3N@186824|Thermoactinomycetaceae	91061|Bacilli	J	Ribosomal protein L19	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
LZS3_k127_3163999_31	862517.HMPREF9225_1693	0.0005558	48.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,22HBZ@1570339|Peptoniphilaceae	186801|Clostridia	S	TrpR family protein YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
LZS3_k127_3163999_25	1121472.AQWN01000002_gene2220	7.134e-15	79.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,262QF@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
LZS3_k127_3163999_5	945713.IALB_1767	1.62e-116	391.0	COG0008@1|root,COG1384@1|root,COG0008@2|Bacteria,COG1384@2|Bacteria	2|Bacteria	J	tRNA binding	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
LZS3_k127_3163999_13	635013.TherJR_2108	8.895e-43	171.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_3163999_20	649747.HMPREF0083_05077	8.285e-20	93.0	2DNS7@1|root,32YWC@2|Bacteria,1VAUX@1239|Firmicutes,4IRUF@91061|Bacilli	91061|Bacilli	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_3163999_22	261292.Nit79A3_0430	7.247e-19	95.0	COG1216@1|root,COG2120@1|root,COG1216@2|Bacteria,COG2120@2|Bacteria,1MZSD@1224|Proteobacteria,2VUX2@28216|Betaproteobacteria,3736Y@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_7C,Glycos_transf_2,PIG-L
LZS3_k127_3163999_26	999630.TUZN_1278	3.642e-14	84.0	COG0535@1|root,arCOG00938@2157|Archaea,2XPPA@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS3_k127_3163999_14	1123373.ATXI01000020_gene1239	7.33e-35	140.0	COG0693@1|root,COG0693@2|Bacteria,2GGYK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
LZS3_k127_3163999_23	552811.Dehly_0016	2.635e-18	89.0	COG0745@1|root,COG0745@2|Bacteria,2GAUB@200795|Chloroflexi,34DD8@301297|Dehalococcoidia	301297|Dehalococcoidia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
LZS3_k127_3163999_12	326427.Cagg_2683	1.112e-45	181.0	COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G66G@200795|Chloroflexi,3754U@32061|Chloroflexia	32061|Chloroflexia	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS
LZS3_k127_3163999_19	309807.SRU_2292	9.495e-21	96.0	COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,1FIR7@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
LZS3_k127_3163999_24	998088.B565_0964	2.655e-17	93.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1Y3R8@135624|Aeromonadales	135624|Aeromonadales	NU	Pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
LZS3_k127_3163999_8	526227.Mesil_2136	2.18e-72	259.0	COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	PFAM Bacterial type II secretion system protein F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
LZS3_k127_3163999_3	696369.KI912183_gene1480	2.442e-125	433.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,2603X@186807|Peptococcaceae	186801|Clostridia	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
LZS3_k127_3163999_29	32024.JMTI01000018_gene623	6.12e-06	57.0	COG0476@1|root,COG0476@2|Bacteria,1R87S@1224|Proteobacteria,42R16@68525|delta/epsilon subdivisions,2YNKH@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Thiamine biosynthesis protein ThiF	thiF	-	2.7.7.73	ko:K03148	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS-like
LZS3_k127_3163999_28	1532557.JL37_27475	1.373e-08	65.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,TrmB
LZS3_k127_3163999_11	1267533.KB906734_gene3767	1.624e-47	190.0	COG0617@1|root,COG0617@2|Bacteria,3Y3B8@57723|Acidobacteria,2JIIS@204432|Acidobacteriia	204432|Acidobacteriia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
LZS3_k127_3163999_4	983545.Glaag_2095	2.861e-122	436.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,464K7@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG1643 HrpA-like helicases	hrpA	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
LZS3_k127_3163999_6	635013.TherJR_0068	3.2e-105	360.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,2602Z@186807|Peptococcaceae	186801|Clostridia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
LZS3_k127_3163999_2	1120985.AUMI01000011_gene609	2.55e-149	486.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H206@909932|Negativicutes	909932|Negativicutes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
LZS3_k127_3163999_16	1499967.BAYZ01000041_gene2377	3.229e-29	123.0	COG0551@1|root,COG0551@2|Bacteria,2NQZQ@2323|unclassified Bacteria	2|Bacteria	L	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_3163999_30	926561.KB900623_gene711	0.0001368	47.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WAC7@53433|Halanaerobiales	186801|Clostridia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
LZS3_k127_3163999_1	665952.HMPREF1015_02477	1.042e-190	616.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,1ZCM9@1386|Bacillus	91061|Bacilli	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
LZS3_k127_32338_4	311424.DhcVS_379	3.171e-58	209.0	COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi,34CY0@301297|Dehalococcoidia	301297|Dehalococcoidia	L	UreE urease accessory protein, C-terminal domain	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
LZS3_k127_32338_1	246194.CHY_1157	1.096e-169	556.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,42F33@68295|Thermoanaerobacterales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
LZS3_k127_32338_2	941824.TCEL_01878	1.665e-156	520.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,36DDP@31979|Clostridiaceae	186801|Clostridia	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
LZS3_k127_32338_6	1123250.KB908379_gene1203	7.57e-10	68.0	COG1426@1|root,COG1426@2|Bacteria,1V9EA@1239|Firmicutes,4H958@909932|Negativicutes	909932|Negativicutes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
LZS3_k127_32338_3	1291050.JAGE01000002_gene3851	2.14e-144	465.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
LZS3_k127_32338_5	1458462.JNLK01000001_gene54	2.05e-10	67.0	COG2137@1|root,COG2137@2|Bacteria	2|Bacteria	S	regulation of DNA repair	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496	2.4.1.337	ko:K03565,ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003,ko03400	-	GT4	-	RecX
LZS3_k127_32338_0	311424.DhcVS_494	4.169e-267	844.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G6K4@200795|Chloroflexi,34CQ2@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
LZS3_k127_32338_7	1408418.JNJH01000020_gene967	1.741e-06	53.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2JV8U@204441|Rhodospirillales	204441|Rhodospirillales	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
LZS3_k127_3382265_2	1094466.KQS_13265	3.711e-17	86.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia,2NX0A@237|Flavobacterium	976|Bacteroidetes	UW	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
LZS3_k127_3382265_0	1048983.EL17_15655	6.113e-231	730.0	COG5421@1|root,COG5421@2|Bacteria,4NJS6@976|Bacteroidetes,47TKZ@768503|Cytophagia	976|Bacteroidetes	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
LZS3_k127_3382265_1	880071.Fleli_3259	4.827e-25	108.0	COG4249@1|root,COG4249@2|Bacteria,4NS33@976|Bacteroidetes,47SWU@768503|Cytophagia	976|Bacteroidetes	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
LZS3_k127_3422345_5	883096.HMPREF9699_00618	4.025e-09	60.0	28SZ2@1|root,2ZF8F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3422345_0	309799.DICTH_1619	1.179e-104	349.0	COG0327@1|root,COG0327@2|Bacteria	2|Bacteria	L	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3422345_2	986075.CathTA2_0342	2.37e-82	277.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,4HA8J@91061|Bacilli	91061|Bacilli	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0006355,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0030163,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051603,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
LZS3_k127_3422345_4	197221.22295115	2.494e-43	174.0	COG0477@1|root,COG2814@2|Bacteria,1G02H@1117|Cyanobacteria	1117|Cyanobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
LZS3_k127_3422345_3	1304284.L21TH_2373	2.49e-61	227.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,36DYI@31979|Clostridiaceae	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
LZS3_k127_3422345_1	439235.Dalk_0893	1.124e-87	303.0	COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,42PGK@68525|delta/epsilon subdivisions,2WJCU@28221|Deltaproteobacteria,2MK38@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase DDE domain	-	-	-	ko:K07495	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4372
LZS3_k127_3546427_6	153948.NAL212_2601	6.23e-21	93.0	COG1943@1|root,COG1943@2|Bacteria,1QKQ2@1224|Proteobacteria,2WC8F@28216|Betaproteobacteria,374G1@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
LZS3_k127_3546427_9	869213.JCM21142_93670	1.312e-08	61.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,47QBE@768503|Cytophagia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3546427_2	1291743.LOSG293_170450	1.115e-35	142.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,4HHI5@91061|Bacilli,3F42W@33958|Lactobacillaceae	91061|Bacilli	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
LZS3_k127_3546427_0	635013.TherJR_1182	1.885e-131	429.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,260GK@186807|Peptococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
LZS3_k127_3546427_3	309799.DICTH_1501	1.211e-29	126.0	COG1636@1|root,COG1636@2|Bacteria	2|Bacteria	C	queuosine biosynthetic process	queH	-	1.17.99.6,3.1.26.4	ko:K03470,ko:K09765	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03032	-	-	-	DUF208
LZS3_k127_3546427_5	1121930.AQXG01000014_gene350	3.281e-24	118.0	COG1404@1|root,COG2356@1|root,COG3291@1|root,COG1404@2|Bacteria,COG2356@2|Bacteria,COG3291@2|Bacteria,4PI1X@976|Bacteroidetes,1IXYZ@117747|Sphingobacteriia	976|Bacteroidetes	L	Endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1
LZS3_k127_3546427_7	586413.CCDL010000003_gene2885	1.003e-12	81.0	COG0737@1|root,COG1404@1|root,COG2374@1|root,COG4085@1|root,COG0737@2|Bacteria,COG1404@2|Bacteria,COG2374@2|Bacteria,COG4085@2|Bacteria,1TPV2@1239|Firmicutes,4HB9S@91061|Bacilli,23JEP@182709|Oceanobacillus	91061|Bacilli	FL	Staphylococcal nuclease homologues	yfkN	-	3.1.3.5,3.1.3.6,3.1.4.16	ko:K01081,ko:K06931,ko:K08693	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	iYO844.BSU07840	5_nucleotid_C,CBM_5_12,Metallophos
LZS3_k127_3546427_4	1121335.Clst_2535	1.475e-26	115.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,3WJJ8@541000|Ruminococcaceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
LZS3_k127_3546427_8	1122947.FR7_0852	1.746e-10	66.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,4H47Z@909932|Negativicutes	909932|Negativicutes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
LZS3_k127_3546427_1	926550.CLDAP_29190	3.981e-40	166.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
LZS3_k127_3825621_11	693661.Arcve_1378	1.127e-44	173.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,246SU@183980|Archaeoglobi	183980|Archaeoglobi	G	PFAM Glucose-6-phosphate isomerase	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
LZS3_k127_3825621_10	1122971.BAME01000013_gene1641	1.883e-48	186.0	COG0042@1|root,COG0042@2|Bacteria,4NEN4@976|Bacteroidetes,2FM9Z@200643|Bacteroidia,22WST@171551|Porphyromonadaceae	976|Bacteroidetes	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	-	-	-	-	-	-	-	-	-	Dus
LZS3_k127_3825621_3	1444712.BN1013_01178	2.166e-136	448.0	COG0215@1|root,COG0215@2|Bacteria,2JFNB@204428|Chlamydiae	204428|Chlamydiae	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
LZS3_k127_3825621_8	649747.HMPREF0083_05798	2.024e-65	229.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,4HAZR@91061|Bacilli,26RVY@186822|Paenibacillaceae	91061|Bacilli	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
LZS3_k127_3825621_1	665952.HMPREF1015_00819	1.041e-187	612.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,4HA6C@91061|Bacilli,1ZB7D@1386|Bacillus	91061|Bacilli	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
LZS3_k127_3825621_15	1122211.JMLW01000017_gene1562	1.867e-06	51.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,1S6E7@1236|Gammaproteobacteria,1XPVA@135619|Oceanospirillales	135619|Oceanospirillales	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3825621_13	402612.FP1030	1.062e-10	64.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,1I4WB@117743|Flavobacteriia,2NWWP@237|Flavobacterium	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3825621_6	394503.Ccel_2057	4.089e-67	242.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,36EJZ@31979|Clostridiaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
LZS3_k127_3825621_2	935836.JAEL01000045_gene3321	7.111e-161	526.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,4H9NB@91061|Bacilli,1ZBAK@1386|Bacillus	91061|Bacilli	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
LZS3_k127_3825621_9	596323.HMPREF0554_1917	1.787e-54	194.0	COG0080@1|root,COG0080@2|Bacteria,379YU@32066|Fusobacteria	32066|Fusobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
LZS3_k127_3825621_7	555079.Toce_2104	1.383e-66	234.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,42FYD@68295|Thermoanaerobacterales	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
LZS3_k127_3825621_14	1089553.Tph_c26100	1.433e-08	58.0	COG0690@1|root,COG0690@2|Bacteria,1UEKM@1239|Firmicutes,25JJ4@186801|Clostridia,42HEH@68295|Thermoanaerobacterales	186801|Clostridia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
LZS3_k127_3825621_12	457570.Nther_0528	5.738e-18	87.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
LZS3_k127_3825621_5	1209989.TepiRe1_1645	1.058e-76	271.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,42EMA@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
LZS3_k127_3825621_0	720554.Clocl_1048	1.435e-289	919.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,3WG9B@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
LZS3_k127_3825621_16	1219084.AP014508_gene88	8.682e-06	53.0	COG2359@1|root,COG2359@2|Bacteria,2GDCT@200918|Thermotogae	200918|Thermotogae	S	PFAM Stage V sporulation protein S	-	-	-	-	-	-	-	-	-	-	-	-	SpoVS
LZS3_k127_3825621_4	1122143.AUEG01000001_gene494	2.633e-84	286.0	arCOG06481@1|root,2ZB4E@2|Bacteria,1V0ND@1239|Firmicutes,4HFG5@91061|Bacilli,27FK3@186828|Carnobacteriaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3879016_16	755178.Cyan10605_2628	0.0002197	47.0	COG3311@1|root,COG3311@2|Bacteria,1G7I0@1117|Cyanobacteria	1117|Cyanobacteria	K	TIGRFAM DNA binding domain, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
LZS3_k127_3879016_0	926550.CLDAP_34830	1.366e-244	777.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
LZS3_k127_3879016_2	1449336.JQLO01000001_gene1698	1.253e-76	274.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,4HANB@91061|Bacilli,27FT4@186828|Carnobacteriaceae	91061|Bacilli	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
LZS3_k127_3879016_5	744872.Spica_1284	1.397e-45	176.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
LZS3_k127_3879016_3	857293.CAAU_1274	1.207e-75	271.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,36DF8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
LZS3_k127_3879016_12	1506583.JQJY01000006_gene4494	1.38e-17	87.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,1I4WB@117743|Flavobacteriia,2NWWP@237|Flavobacterium	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3879016_6	1499685.CCFJ01000046_gene3553	2.638e-41	168.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,1ZDBF@1386|Bacillus	91061|Bacilli	L	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
LZS3_k127_3879016_10	1168034.FH5T_10405	7.599e-20	94.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,2FTYU@200643|Bacteroidia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3879016_13	1382356.JQMP01000003_gene1422	2.803e-14	80.0	COG0671@1|root,COG0671@2|Bacteria,2G7BP@200795|Chloroflexi	200795|Chloroflexi	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
LZS3_k127_3879016_11	1396858.Q666_04200	1.584e-18	89.0	COG0614@1|root,COG0614@2|Bacteria,1N7EM@1224|Proteobacteria,1S6E7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3879016_4	767817.Desgi_1872	8.53e-61	220.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,260XY@186807|Peptococcaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
LZS3_k127_3879016_15	1451261.AS96_14610	2.553e-05	58.0	COG3704@1|root,COG3704@2|Bacteria	2|Bacteria	U	protein secretion by the type IV secretion system	-	-	-	ko:K03201	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	3.A.7	-	-	TrbL
LZS3_k127_3879016_9	1168034.FH5T_04510	2.164e-20	96.0	COG0614@1|root,COG0614@2|Bacteria,4NQ88@976|Bacteroidetes,2FV11@200643|Bacteroidia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3879016_14	886882.PPSC2_p0161	4.733e-14	83.0	2DQGV@1|root,336S4@2|Bacteria,1VJ0B@1239|Firmicutes,4HZH4@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3879016_7	1233950.IW22_09585	8.235e-30	122.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1I2SV@117743|Flavobacteriia,3ZS3U@59732|Chryseobacterium	976|Bacteroidetes	J	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_3879016_1	330084.JNYZ01000022_gene3759	1.331e-117	400.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4E1I0@85010|Pseudonocardiales	201174|Actinobacteria	U	Type IV secretory pathway, VirB4	-	-	-	-	-	-	-	-	-	-	-	-	AAA_10,DUF87,PrgI
LZS3_k127_3879016_8	880073.Calab_3016	9.332e-23	102.0	COG0614@1|root,COG0614@2|Bacteria,2NRKR@2323|unclassified Bacteria	2|Bacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_3973645_6	1506583.JQJY01000006_gene4502	2.403e-07	65.0	COG1345@1|root,COG1520@1|root,COG1345@2|Bacteria,COG1520@2|Bacteria,4NFVP@976|Bacteroidetes,1HY1K@117743|Flavobacteriia,2NSFX@237|Flavobacterium	976|Bacteroidetes	N	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	PA14
LZS3_k127_3973645_3	929713.NIASO_18845	1.034e-16	84.0	COG0724@1|root,COG0724@2|Bacteria,4NV5J@976|Bacteroidetes	976|Bacteroidetes	S	RNA-binding protein	ykfA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
LZS3_k127_3973645_2	857293.CAAU_0264	1.163e-64	229.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,36E73@31979|Clostridiaceae	186801|Clostridia	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
LZS3_k127_3973645_4	1120980.JQKH01000102_gene591	4.773e-15	83.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KQ2R@206351|Neisseriales	206351|Neisseriales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
LZS3_k127_3973645_1	1122222.AXWR01000030_gene2321	2.027e-75	268.0	COG0389@1|root,COG0389@2|Bacteria,1WKFJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
LZS3_k127_3973645_0	1408422.JHYF01000003_gene872	0.0	1146.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
LZS3_k127_3973645_7	537970.HCAN_0954	4.035e-07	58.0	COG1664@1|root,COG1664@2|Bacteria	2|Bacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
LZS3_k127_3973645_8	1304284.L21TH_2186	0.0002935	50.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,25CN4@186801|Clostridia,36WY7@31979|Clostridiaceae	186801|Clostridia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
LZS3_k127_414127_1	396588.Tgr7_2368	1.601e-66	233.0	COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,1RN4M@1236|Gammaproteobacteria,1X19U@135613|Chromatiales	135613|Chromatiales	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_414127_0	396588.Tgr7_2376	5.121e-109	365.0	COG3919@1|root,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,1RQ74@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,LMWPc
LZS3_k127_414127_2	396588.Tgr7_2369	3.519e-66	231.0	COG5653@1|root,COG5653@2|Bacteria,1QUMR@1224|Proteobacteria,1RN5W@1236|Gammaproteobacteria,1WVWZ@135613|Chromatiales	135613|Chromatiales	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
LZS3_k127_425599_1	1078085.HMPREF1210_00999	8.18e-16	85.0	COG0500@1|root,COG0500@2|Bacteria,1V0PR@1239|Firmicutes,4HB7J@91061|Bacilli,26EB3@186818|Planococcaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
LZS3_k127_425599_2	639282.DEFDS_0358	5.819e-07	55.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
LZS3_k127_425599_0	858215.Thexy_1896	5.482e-38	151.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,42FNR@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
LZS3_k127_4266939_1	298653.Franean1_6456	2.311e-09	68.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ2	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,NERD
LZS3_k127_4266939_0	1223521.BBJX01000010_gene203	4.358e-22	107.0	COG1028@1|root,COG1028@2|Bacteria,1RBAD@1224|Proteobacteria,2VI9U@28216|Betaproteobacteria,4AA6I@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase Sdr	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4428877_12	309801.trd_0060	2.208e-65	235.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi,27Y23@189775|Thermomicrobia	189775|Thermomicrobia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4
LZS3_k127_4428877_8	237368.SCABRO_00429	1.491e-80	287.0	COG0771@1|root,COG0771@2|Bacteria,2IX53@203682|Planctomycetes	203682|Planctomycetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
LZS3_k127_4428877_9	401526.TcarDRAFT_0183	4.927e-80	280.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,4H3RE@909932|Negativicutes	909932|Negativicutes	D	TIGRFAM stage V sporulation protein E, cell division protein FtsW	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
LZS3_k127_4428877_17	406124.ACPC01000018_gene2564	2.116e-50	192.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,4HBAQ@91061|Bacilli,1ZBA5@1386|Bacillus	91061|Bacilli	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
LZS3_k127_4428877_11	1304885.AUEY01000047_gene74	1.959e-65	239.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
LZS3_k127_4428877_15	1047013.AQSP01000139_gene2386	6.965e-53	198.0	COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
LZS3_k127_4428877_34	1246626.BleG1_2339	5.074e-06	57.0	COG1589@1|root,COG1589@2|Bacteria,1V6V5@1239|Firmicutes,4HDFD@91061|Bacilli,1ZDSW@1386|Bacillus	91061|Bacilli	D	Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex	divIB	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
LZS3_k127_4428877_5	1121289.JHVL01000004_gene2046	7.724e-112	381.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,36EVY@31979|Clostridiaceae	186801|Clostridia	L	Single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
LZS3_k127_4428877_20	945713.IALB_1410	1.354e-24	108.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
LZS3_k127_4428877_2	1274524.BSONL12_21849	2.593e-128	424.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,1ZB8H@1386|Bacillus	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
LZS3_k127_4428877_29	452637.Oter_1864	1.946e-07	61.0	COG3327@1|root,COG3327@2|Bacteria,46W9G@74201|Verrucomicrobia	74201|Verrucomicrobia	K	negative regulation of DNA-templated transcription, initiation	-	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX_C
LZS3_k127_4428877_0	316274.Haur_3225	7.618e-131	452.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi,374XI@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
LZS3_k127_4428877_3	457570.Nther_1811	2.476e-116	387.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
LZS3_k127_4428877_1	1123372.AUIT01000001_gene689	1.005e-129	432.0	COG0018@1|root,COG0018@2|Bacteria,2GGTB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
LZS3_k127_4428877_21	562970.Btus_1957	3.794e-20	93.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli	91061|Bacilli	K	Cold-Shock Protein	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
LZS3_k127_4428877_36	309801.trd_0003	1.477e-05	58.0	COG0631@1|root,COG0631@2|Bacteria,2G72P@200795|Chloroflexi,27XJ8@189775|Thermomicrobia	189775|Thermomicrobia	T	protein serine/threonine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4428877_18	1379698.RBG1_1C00001G1030	1.046e-43	167.0	COG1994@1|root,COG1994@2|Bacteria,2NPQP@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	ywhC	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M50
LZS3_k127_4428877_24	690850.Desaf_2354	1.106e-09	61.0	COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria,2MD8Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
LZS3_k127_4428877_22	693746.OBV_22070	3.841e-20	94.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,2N7GS@216572|Oscillospiraceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
LZS3_k127_4428877_30	658187.LDG_7748	2.808e-07	61.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1JCXJ@118969|Legionellales	118969|Legionellales	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
LZS3_k127_4428877_16	1308866.J416_12542	6.034e-52	193.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,4H9M9@91061|Bacilli,4708E@74385|Gracilibacillus	91061|Bacilli	S	PSP1 C-terminal conserved region	yaaT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	PSP1
LZS3_k127_4428877_35	1173024.KI912150_gene1341	9.714e-06	56.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G0BJ@1117|Cyanobacteria,1JI0B@1189|Stigonemataceae	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
LZS3_k127_4428877_27	1235811.HMPREF0653_01096	1.337e-08	64.0	2DSX2@1|root,33HSD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4428877_25	765952.PUV_18030	1.607e-09	62.0	COG1961@1|root,COG1961@2|Bacteria,2JGRW@204428|Chlamydiae	204428|Chlamydiae	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase,Zn_ribbon_recom
LZS3_k127_4428877_32	329726.AM1_4813	5.7e-07	53.0	COG0267@1|root,COG0267@2|Bacteria,1G96P@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
LZS3_k127_4428877_23	931626.Awo_c00630	1.258e-17	86.0	COG4728@1|root,COG4728@2|Bacteria	2|Bacteria	FJ	Protein conserved in bacteria	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	DUF1653
LZS3_k127_4428877_13	382464.ABSI01000011_gene2992	1.415e-58	209.0	COG0299@1|root,COG0299@2|Bacteria,46SS6@74201|Verrucomicrobia,2IU5Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
LZS3_k127_4428877_4	648996.Theam_0511	1.968e-112	392.0	COG2804@1|root,COG2804@2|Bacteria,2G3UR@200783|Aquificae	200783|Aquificae	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
LZS3_k127_4428877_6	749927.AMED_4452	4.625e-107	357.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria	201174|Actinobacteria	NU	twitching motility protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
LZS3_k127_4428877_10	1449357.JQLK01000001_gene2167	9.903e-73	260.0	COG1459@1|root,COG1459@2|Bacteria,1WIU3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	PFAM Bacterial type II secretion system protein F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
LZS3_k127_4428877_37	1470591.BW41_02597	2.472e-05	53.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U7GY@28211|Alphaproteobacteria,2KCC3@204457|Sphingomonadales	204457|Sphingomonadales	NU	Type II secretion system (T2SS), protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
LZS3_k127_4428877_26	1122130.AUHN01000008_gene1585	7.271e-09	63.0	COG2165@1|root,COG2165@2|Bacteria,2GTN8@201174|Actinobacteria	201174|Actinobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
LZS3_k127_4428877_14	748727.CLJU_c05610	3.184e-53	197.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,36H8M@31979|Clostridiaceae	186801|Clostridia	NOU	peptidase	hofD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
LZS3_k127_4428877_33	1545915.JROG01000007_gene3091	1.431e-06	57.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U8VA@28211|Alphaproteobacteria,2K4TG@204457|Sphingomonadales	204457|Sphingomonadales	NU	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
LZS3_k127_4428877_7	865861.AZSU01000009_gene624	5.796e-107	358.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,36DNK@31979|Clostridiaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
LZS3_k127_4428877_19	748449.Halha_1865	5.599e-31	127.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia	186801|Clostridia	L	PFAM ribonuclease H	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
LZS3_k127_4428877_28	86106.I862_03615	1.514e-07	56.0	COG1872@1|root,COG1872@2|Bacteria	2|Bacteria	I	DUF167	CP_0257	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
LZS3_k127_4478445_1	595536.ADVE02000001_gene282	0.0003408	51.0	COG0515@1|root,COG0515@2|Bacteria,1N8ZQ@1224|Proteobacteria,2UGUX@28211|Alphaproteobacteria,3703M@31993|Methylocystaceae	28211|Alphaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4478445_0	880073.Calab_1805	1.078e-28	122.0	COG1595@1|root,COG1595@2|Bacteria,2NRM3@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
LZS3_k127_4824916_4	574087.Acear_0995	2.16e-47	176.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3WC58@53433|Halanaerobiales	186801|Clostridia	C	Ferritin-like domain	rbr	GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
LZS3_k127_4824916_7	1047013.AQSP01000123_gene1538	2.26e-38	147.0	COG2033@1|root,COG2033@2|Bacteria,2NPTG@2323|unclassified Bacteria	2|Bacteria	C	Desulfoferrodoxin, N-terminal domain	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
LZS3_k127_4824916_11	99598.Cal7507_2247	1.363e-22	104.0	COG0494@1|root,COG0494@2|Bacteria,1G60V@1117|Cyanobacteria,1HMV1@1161|Nostocales	1117|Cyanobacteria	L	PFAM NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
LZS3_k127_4824916_21	595593.JREV01000067_gene1881	9.065e-05	55.0	COG4632@1|root,COG4632@2|Bacteria,2HZP5@201174|Actinobacteria,1WAFN@1268|Micrococcaceae	201174|Actinobacteria	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
LZS3_k127_4824916_1	387631.Asulf_01706	5.257e-63	219.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
LZS3_k127_4824916_3	1313301.AUGC01000010_gene881	7.192e-49	200.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
LZS3_k127_4824916_10	751944.HALDL1_02015	1.855e-24	116.0	arCOG04555@1|root,arCOG04555@2157|Archaea,2XUY2@28890|Euryarchaeota,23TMB@183963|Halobacteria	183963|Halobacteria	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
LZS3_k127_4824916_6	1121035.AUCH01000004_gene282	1.672e-44	174.0	2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,2VUDX@28216|Betaproteobacteria,2KYD2@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_2	509191.AEDB02000022_gene2922	2.565e-49	192.0	COG1520@1|root,COG3509@1|root,COG1520@2|Bacteria,COG3509@2|Bacteria,1VUN0@1239|Firmicutes	1239|Firmicutes	DZ	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
LZS3_k127_4824916_22	1196031.ALEG01000035_gene864	0.0001689	46.0	29TAG@1|root,30EHH@2|Bacteria,1UCJJ@1239|Firmicutes,4IP1R@91061|Bacilli,1ZP94@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_8	1196031.ALEG01000035_gene865	7.182e-28	114.0	2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes,4IIGE@91061|Bacilli,1ZNM9@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_12	498761.HM1_3148	2.991e-21	95.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_13	1280001.BAOA01000033_gene2227	4.952e-21	94.0	2DMHR@1|root,32RMI@2|Bacteria,1QK1W@1224|Proteobacteria,1TI4F@1236|Gammaproteobacteria,1XYCQ@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_19	1448857.JFAP01000017_gene2	1.929e-05	46.0	2AJ0G@1|root,319IH@2|Bacteria,1Q2VV@1224|Proteobacteria,42WBS@68525|delta/epsilon subdivisions,2YQAG@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_24	445974.CLORAM_00002	0.0004293	44.0	2E4EA@1|root,32Z9I@2|Bacteria,1VG12@1239|Firmicutes,3VS83@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_25	85962.C694_04615	0.0005777	48.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS11355	HupF_HypC
LZS3_k127_4824916_17	1121935.AQXX01000025_gene1583	8.183e-06	49.0	2EMPC@1|root,33FBT@2|Bacteria,1QNQV@1224|Proteobacteria,1SI44@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_20	106370.Francci3_0265	4.506e-05	51.0	2FCKD@1|root,344PQ@2|Bacteria,2GVQX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4824916_18	1121104.AQXH01000004_gene112	1.914e-05	57.0	COG4726@1|root,COG4726@2|Bacteria	2|Bacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	DUF4900,PilX_N
LZS3_k127_4824916_23	395961.Cyan7425_0351	0.0003696	50.0	COG3118@1|root,COG3118@2|Bacteria,1G6KZ@1117|Cyanobacteria,3KHX2@43988|Cyanothece	2|Bacteria	O	Belongs to the thioredoxin family	trx-1	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
LZS3_k127_4824916_5	469383.Cwoe_3142	3.138e-47	183.0	COG4932@1|root,COG4932@2|Bacteria,2GJ4T@201174|Actinobacteria,4CSJH@84995|Rubrobacteria	84995|Rubrobacteria	M	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3494
LZS3_k127_4824916_9	525904.Tter_0567	1.682e-25	114.0	COG3103@1|root,COG3764@1|root,COG3103@2|Bacteria,COG3764@2|Bacteria	2|Bacteria	M	Sortase family	ylcC	-	3.4.22.70,3.5.1.104	ko:K07284,ko:K22278	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
LZS3_k127_4824916_16	1121097.JCM15093_1533	2.892e-10	69.0	COG2944@1|root,COG2944@2|Bacteria,4PPID@976|Bacteroidetes,2G3B8@200643|Bacteroidia	976|Bacteroidetes	K	Protein of unknown function (DUF4065)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4065
LZS3_k127_4824916_0	269797.Mbar_A1714	1.717e-94	316.0	arCOG01792@1|root,arCOG01792@2157|Archaea,2XSXC@28890|Euryarchaeota,2N9K5@224756|Methanomicrobia	224756|Methanomicrobia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
LZS3_k127_4931003_0	1304284.L21TH_1432	2.388e-138	471.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,36EV7@31979|Clostridiaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
LZS3_k127_4931003_3	1304880.JAGB01000002_gene2050	6.902e-18	90.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia	186801|Clostridia	L	TIGRFAM Competence protein ComEA, helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
LZS3_k127_4931003_5	648996.Theam_1348	1.149e-09	68.0	COG0457@1|root,COG0457@2|Bacteria	648996.Theam_1348|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_4931003_2	1265505.ATUG01000003_gene184	2.68e-40	159.0	COG1277@1|root,COG1277@2|Bacteria,1NCXV@1224|Proteobacteria,42VK2@68525|delta/epsilon subdivisions,2WRNT@28221|Deltaproteobacteria,2MPXF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
LZS3_k127_4931003_4	1250006.JHZZ01000001_gene1610	1.183e-15	81.0	COG0614@1|root,COG0614@2|Bacteria,4PK1S@976|Bacteroidetes,1IME4@117743|Flavobacteriia,3VXES@52959|Polaribacter	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_4931003_1	864702.OsccyDRAFT_2782	8.936e-62	222.0	COG1131@1|root,COG1131@2|Bacteria,1G0UC@1117|Cyanobacteria,1H9JW@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS3_k127_4939248_9	469617.FUAG_03029	6.195e-11	72.0	COG0360@1|root,COG0360@2|Bacteria,37APH@32066|Fusobacteria	32066|Fusobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
LZS3_k127_4939248_6	583345.Mmol_2131	1.431e-33	135.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,2KMPH@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
LZS3_k127_4939248_8	747365.Thena_0269	4.241e-17	83.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,42H4H@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
LZS3_k127_4939248_4	572479.Hprae_0883	5.591e-42	160.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,3WAPV@53433|Halanaerobiales	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
LZS3_k127_4939248_10	645991.Sgly_0196	8.499e-07	57.0	COG3881@1|root,COG3881@2|Bacteria,1V29A@1239|Firmicutes,24GY0@186801|Clostridia,261QN@186807|Peptococcaceae	186801|Clostridia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
LZS3_k127_4939248_0	373903.Hore_02010	5.305e-201	639.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WAF0@53433|Halanaerobiales	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
LZS3_k127_4939248_7	448385.sce5910	3.725e-25	107.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
LZS3_k127_4939248_11	945713.IALB_2767	4.773e-05	53.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	KNTase_C,NTP_transf_2
LZS3_k127_4939248_1	592015.HMPREF1705_00235	2.988e-167	542.0	COG0504@1|root,COG0504@2|Bacteria,3TAA0@508458|Synergistetes	508458|Synergistetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
LZS3_k127_4939248_2	697303.Thewi_2219	2.359e-155	521.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
LZS3_k127_4939248_3	926569.ANT_06210	6.301e-60	230.0	COG2720@1|root,COG2720@2|Bacteria,2G67R@200795|Chloroflexi	200795|Chloroflexi	V	PFAM VanW family protein	-	-	-	-	-	-	-	-	-	-	-	-	G5,PG_binding_4,VanW
LZS3_k127_4939248_5	497964.CfE428DRAFT_4882	4.44e-41	176.0	2F6CM@1|root,33YVZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5135785_7	717231.Flexsi_1964	1.03e-14	79.0	COG1837@1|root,COG1837@2|Bacteria,2GFZI@200930|Deferribacteres	200930|Deferribacteres	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
LZS3_k127_5135785_5	765420.OSCT_2871	6.931e-19	91.0	COG0228@1|root,COG0228@2|Bacteria,2G7A3@200795|Chloroflexi,377I8@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
LZS3_k127_5135785_3	1399115.U719_10860	8.554e-60	224.0	COG0223@1|root,COG0242@1|root,COG0223@2|Bacteria,COG0242@2|Bacteria,1TQ32@1239|Firmicutes,4HART@91061|Bacilli,3WEBX@539002|Bacillales incertae sedis	91061|Bacilli	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06010	Formyl_trans_C,Formyl_trans_N
LZS3_k127_5135785_2	309799.DICTH_1238	8.597e-81	283.0	COG1087@1|root,COG1087@2|Bacteria	2|Bacteria	M	UDP-glucose 4-epimerase activity	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
LZS3_k127_5135785_0	574087.Acear_1443	7.29e-132	445.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WACI@53433|Halanaerobiales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
LZS3_k127_5135785_1	1341151.ASZU01000017_gene1764	1.577e-89	310.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,4HAJ6@91061|Bacilli,27BMY@186824|Thermoactinomycetaceae	91061|Bacilli	S	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
LZS3_k127_5135785_4	309799.DICTH_1422	3.373e-33	138.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
LZS3_k127_5135785_6	1158318.ATXC01000001_gene775	1.077e-18	95.0	COG0682@1|root,COG0682@2|Bacteria,2G41A@200783|Aquificae	200783|Aquificae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
LZS3_k127_5263356_1	1047013.AQSP01000124_gene2652	4.177e-52	198.0	COG2605@1|root,COG2605@2|Bacteria,2NRFW@2323|unclassified Bacteria	2|Bacteria	S	GHMP kinases N terminal domain	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,GHMP_kinases_C,GHMP_kinases_N
LZS3_k127_5263356_0	500633.CLOHIR_00024	2.376e-151	488.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,25QJU@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
LZS3_k127_5368431_2	555088.DealDRAFT_2375	1.556e-62	230.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,42JQ7@68298|Syntrophomonadaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
LZS3_k127_5368431_1	1123371.ATXH01000021_gene1117	7.288e-115	383.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
LZS3_k127_5368431_4	479434.Sthe_2499	4.773e-30	129.0	29JD5@1|root,306AN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5368431_5	945713.IALB_2017	1.558e-29	122.0	COG2852@1|root,COG2852@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	-	-	2.1.1.72	ko:K03427,ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03400	-	-	-	DUF559
LZS3_k127_5368431_8	585503.HMPREF7545_0950	4.01e-14	83.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4H2XX@909932|Negativicutes	909932|Negativicutes	L	DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
LZS3_k127_5368431_10	1121928.AUHE01000005_gene1046	0.0003212	53.0	COG4907@1|root,COG4907@2|Bacteria,2GNW7@201174|Actinobacteria,4GBYI@85026|Gordoniaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
LZS3_k127_5368431_6	1121430.JMLG01000028_gene1476	2.193e-24	109.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,261SF@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
LZS3_k127_5368431_9	485913.Krac_8264	2.709e-06	52.0	COG0268@1|root,COG0268@2|Bacteria,2G7AK@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
LZS3_k127_5368431_3	926561.KB900623_gene1087	3.58e-43	173.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WAJB@53433|Halanaerobiales	186801|Clostridia	S	phosphoesterase RecJ domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
LZS3_k127_5368431_7	1029718.SFBM_0735	6.352e-24	106.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,36KHC@31979|Clostridiaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
LZS3_k127_5368431_0	292459.STH1531	3.287e-187	608.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
LZS3_k127_5506598_2	1123376.AUIU01000003_gene1644	4.222e-08	60.0	COG1476@1|root,COG1476@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	xre	-	-	-	-	-	-	-	-	-	-	-	HTH_3
LZS3_k127_5506598_1	1042163.BRLA_c040530	2.005e-35	149.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE6D@91061|Bacilli,26RGF@186822|Paenibacillaceae	91061|Bacilli	M	enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
LZS3_k127_5506598_0	65093.PCC7418_2353	1.13e-118	392.0	COG0012@1|root,COG0012@2|Bacteria,1G1PW@1117|Cyanobacteria	1117|Cyanobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
LZS3_k127_5558185_6	1125700.HMPREF9195_00131	8.041e-14	72.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
LZS3_k127_5558185_0	574087.Acear_0276	2.837e-259	827.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WAH3@53433|Halanaerobiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
LZS3_k127_5558185_1	1158318.ATXC01000001_gene27	9.616e-151	493.0	COG0696@1|root,COG0696@2|Bacteria	2|Bacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_3895,iJN678.yibO,iJN746.PP_5056	Metalloenzyme,Phosphodiest,iPGM_N
LZS3_k127_5558185_2	756499.Desde_4054	2.242e-78	270.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,25ZZ9@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM Cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
LZS3_k127_5558185_4	1209989.TepiRe1_1784	3.889e-33	139.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,42FMA@68295|Thermoanaerobacterales	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
LZS3_k127_5558185_5	1216932.CM240_1102	1e-16	92.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,36FVZ@31979|Clostridiaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
LZS3_k127_5558185_3	926569.ANT_12940	5.218e-76	271.0	COG0793@1|root,COG0793@2|Bacteria,2G6HR@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
LZS3_k127_5704154_12	1245471.PCA10_16790	9.455e-15	91.0	COG3210@1|root,COG3210@2|Bacteria,1QUUN@1224|Proteobacteria	1224|Proteobacteria	U	Outer membrane autotransporter	-	-	-	ko:K19231	-	-	-	-	ko00000,ko02000	1.B.12	-	-	Big_3_3,ESPR,PATR
LZS3_k127_5704154_13	1094980.Mpsy_0731	2.056e-09	71.0	arCOG06534@1|root,arCOG06534@2157|Archaea,2Y2GI@28890|Euryarchaeota,2NAF1@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
LZS3_k127_5704154_8	648996.Theam_0533	3.162e-37	161.0	COG3291@1|root,COG4870@1|root,COG3291@2|Bacteria,COG4870@2|Bacteria,2G57S@200783|Aquificae	200783|Aquificae	O	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
LZS3_k127_5704154_2	632292.Calhy_0922	8.878e-116	406.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
LZS3_k127_5704154_17	388413.ALPR1_09620	3.714e-05	49.0	COG0399@1|root,COG0399@2|Bacteria,4NS7A@976|Bacteroidetes,47X4X@768503|Cytophagia	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_5704154_14	1408823.AXUS01000026_gene1539	2.14e-07	55.0	COG1141@1|root,COG1141@2|Bacteria,1VKVT@1239|Firmicutes,24RTU@186801|Clostridia	186801|Clostridia	C	ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
LZS3_k127_5704154_16	1458275.AZ34_17075	3.812e-06	51.0	COG1937@1|root,COG1937@2|Bacteria,1NFTB@1224|Proteobacteria,2WFRC@28216|Betaproteobacteria,4AFTC@80864|Comamonadaceae	28216|Betaproteobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
LZS3_k127_5704154_4	880072.Desac_0814	2.197e-61	227.0	COG0695@1|root,COG0695@2|Bacteria,1QVSK@1224|Proteobacteria,43DC6@68525|delta/epsilon subdivisions,2X8I6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5704154_10	1123035.ARLA01000022_gene697	2.218e-27	115.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IKS6@117743|Flavobacteriia,4C4DP@83612|Psychroflexus	976|Bacteroidetes	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
LZS3_k127_5704154_5	565033.GACE_2148	2.476e-57	208.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,246ZF@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
LZS3_k127_5704154_3	1158345.JNLL01000001_gene181	4.542e-62	220.0	COG1180@1|root,COG1180@2|Bacteria,2G49Z@200783|Aquificae	200783|Aquificae	O	Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
LZS3_k127_5704154_0	96561.Dole_2570	3.378e-299	932.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria,2MHTW@213118|Desulfobacterales	28221|Deltaproteobacteria	F	anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
LZS3_k127_5704154_15	1235793.C809_00024	1.358e-06	55.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,27PQD@186928|unclassified Lachnospiraceae	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
LZS3_k127_5704154_6	243231.GSU1945	7.702e-44	179.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1Q4PP@1224|Proteobacteria,42YRG@68525|delta/epsilon subdivisions,2WUJR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
LZS3_k127_5704154_9	1250278.JQNQ01000001_gene3021	2.676e-31	131.0	COG1808@1|root,COG1808@2|Bacteria,4NDXI@976|Bacteroidetes,1HY44@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
LZS3_k127_5704154_11	694440.JOMF01000008_gene1053	9.036e-26	115.0	COG0785@1|root,arCOG02400@2157|Archaea,2Y0J2@28890|Euryarchaeota,2NBK2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM cytochrome c biogenesis protein, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
LZS3_k127_5704154_18	237368.SCABRO_01224	0.0001648	50.0	2DBYC@1|root,2ZBUF@2|Bacteria,2IZ15@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
LZS3_k127_5704154_1	1461580.CCAS010000002_gene364	1.035e-178	584.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,4HAI0@91061|Bacilli,1ZAVE@1386|Bacillus	91061|Bacilli	P	P-type ATPase	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
LZS3_k127_6114841_4	1506583.JQJY01000002_gene1529	4.329e-09	68.0	COG4928@1|root,COG4928@2|Bacteria,4NJBT@976|Bacteroidetes,1IIAB@117743|Flavobacteriia,2P0C1@237|Flavobacterium	976|Bacteroidetes	S	KAP family P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	KAP_NTPase
LZS3_k127_6114841_5	877418.ATWV01000004_gene1950	1.239e-08	64.0	COG1974@1|root,COG1974@2|Bacteria,2J7ID@203691|Spirochaetes	203691|Spirochaetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
LZS3_k127_6114841_3	1144343.PMI41_02432	8.594e-19	88.0	2ECVJ@1|root,32NJ0@2|Bacteria,1Q8P8@1224|Proteobacteria,2UXD0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2188)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2188
LZS3_k127_6114841_1	646529.Desaci_1291	2.14e-43	175.0	COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1TPHP@1239|Firmicutes,249MR@186801|Clostridia,25ZZ4@186807|Peptococcaceae	186801|Clostridia	KL	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase,ParBc
LZS3_k127_6114841_2	754027.HMPREF9554_00696	3.376e-32	143.0	COG5362@1|root,COG5362@2|Bacteria,2JAAR@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM Phage	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6114841_6	326423.RBAM_036070	0.0007889	49.0	2DY9G@1|root,348S7@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4352)	yxkC	-	-	-	-	-	-	-	-	-	-	-	DUF4352
LZS3_k127_6114841_0	760142.Hipma_0827	1.238e-62	232.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
LZS3_k127_6114914_1	419947.MRA_3418	1.542e-47	177.0	28XHJ@1|root,2ZJEY@2|Bacteria	2|Bacteria	S	transferase activity, transferring alkyl or aryl (other than methyl) groups	-	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016101,GO:0016102,GO:0016114,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0035440,GO:0042578,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0075136,GO:1901576	3.1.7.12,3.1.7.8,3.1.7.9	ko:K15911,ko:K22313	-	-	-	-	ko00000,ko01000	-	-	-	-
LZS3_k127_6114914_0	419947.MRA_3417	2.182e-167	540.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria	201174|Actinobacteria	I	Squalene--hopene cyclase	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009267,GO:0009605,GO:0009607,GO:0009975,GO:0009987,GO:0009991,GO:0010350,GO:0016101,GO:0016102,GO:0016114,GO:0016853,GO:0016872,GO:0019637,GO:0031667,GO:0031668,GO:0031669,GO:0033385,GO:0033554,GO:0035439,GO:0035440,GO:0042594,GO:0043167,GO:0043169,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071496,GO:0071704,GO:0075136,GO:1901576	5.5.1.16	ko:K17811	-	-	-	-	ko00000,ko01000	-	-	-	Prenyltrans,SQHop_cyclase_C
LZS3_k127_6114914_2	1128421.JAGA01000002_gene1753	2.17e-07	62.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
LZS3_k127_6319702_0	1382356.JQMP01000003_gene2325	2.382e-110	366.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi,27XT6@189775|Thermomicrobia	189775|Thermomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH1	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
LZS3_k127_6319702_1	1301100.HG529411_gene335	2.775e-54	203.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,36EWX@31979|Clostridiaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
LZS3_k127_6319702_4	1408422.JHYF01000011_gene3435	1.742e-08	66.0	2BBGP@1|root,32502@2|Bacteria,1UR4U@1239|Firmicutes,258YP@186801|Clostridia,36S25@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6319702_2	1123501.KB902284_gene2245	1.321e-22	105.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,HemolysinCabind
LZS3_k127_6319702_3	509191.AEDB02000063_gene432	1.841e-16	86.0	COG0681@1|root,COG0681@2|Bacteria,1V2HE@1239|Firmicutes,24R2U@186801|Clostridia	186801|Clostridia	U	Signal peptidase I	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
LZS3_k127_6525799_0	768670.Calni_0738	2.253e-81	292.0	COG4907@1|root,COG4907@2|Bacteria,2GF9W@200930|Deferribacteres	200930|Deferribacteres	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
LZS3_k127_6525799_1	1121468.AUBR01000005_gene97	2.044e-62	229.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,42FW0@68295|Thermoanaerobacterales	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_6525799_2	1500894.JQNN01000001_gene1816	2.775e-05	53.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	pilE	-	-	ko:K02650,ko:K02655	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
LZS3_k127_6539012_1	698769.JFBD01000065_gene1556	7.999e-43	171.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,4H9YH@91061|Bacilli	2|Bacteria	J	Catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA	asnS_2	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
LZS3_k127_6539012_5	1463936.JOJI01000067_gene7168	4.898e-17	91.0	COG0500@1|root,COG2226@2|Bacteria,2ISQZ@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
LZS3_k127_6539012_0	67593.Physo135458	6.779e-78	272.0	COG1619@1|root,2S19A@2759|Eukaryota,3QEXS@4776|Peronosporales	4776|Peronosporales	V	LD-carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S66
LZS3_k127_6539012_2	661478.OP10G_2052	5.976e-42	169.0	COG3705@1|root,COG3705@2|Bacteria	2|Bacteria	E	histidine biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6539012_3	873448.STRPO_0497	8.511e-42	165.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,4HD4R@91061|Bacilli	91061|Bacilli	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,Shikimate_DH,Shikimate_dh_N
LZS3_k127_6539012_4	797302.Halru_2343	1.101e-27	120.0	COG0317@1|root,arCOG06870@2157|Archaea,2Y3MA@28890|Euryarchaeota,23ZQ5@183963|Halobacteria	183963|Halobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6852811_4	555079.Toce_1360	4.08e-18	88.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,42FUD@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
LZS3_k127_6852811_2	311424.DhcVS_994	3.014e-47	180.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi,34CQQ@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
LZS3_k127_6852811_0	273068.TTE0143	2.083e-104	351.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
LZS3_k127_6852811_3	203119.Cthe_2172	1.525e-23	102.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia	186801|Clostridia	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
LZS3_k127_6852811_1	592015.HMPREF1705_00643	4.252e-54	205.0	COG3464@1|root,COG3464@2|Bacteria,3TCGB@508458|Synergistetes	2|Bacteria	L	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
LZS3_k127_6956519_0	1121451.DESAM_23095	4.897e-31	133.0	COG0535@1|root,COG0535@2|Bacteria,1RG5U@1224|Proteobacteria,42RKR@68525|delta/epsilon subdivisions,2WNUX@28221|Deltaproteobacteria,2MAGK@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
LZS3_k127_6956519_4	880070.Cycma_0901	3.536e-07	60.0	COG0454@1|root,COG0456@2|Bacteria,4NQ9E@976|Bacteroidetes,47Q21@768503|Cytophagia	976|Bacteroidetes	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
LZS3_k127_6956519_1	1045858.Bint_1977	7.303e-31	124.0	2DT5B@1|root,33ISI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6956519_2	1045858.Bint_1976	7.736e-22	98.0	2DFN7@1|root,2ZSE0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6956519_3	1331060.RLDS_24005	2.328e-14	78.0	COG0565@1|root,COG2827@1|root,COG0565@2|Bacteria,COG2827@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JZUG@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,SpoU_methylase
LZS3_k127_7004415_9	113355.CM001775_gene1875	1.486e-27	120.0	COG0741@1|root,COG1729@1|root,COG4105@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,COG4105@2|Bacteria,1G1HC@1117|Cyanobacteria	1117|Cyanobacteria	M	Soluble lytic murein	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,TPR_6
LZS3_k127_7004415_0	1174504.AJTN02000228_gene1933	3.215e-193	621.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,4H9XC@91061|Bacilli,1ZB9E@1386|Bacillus	91061|Bacilli	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2c,tRNA_SAD
LZS3_k127_7004415_4	1382306.JNIM01000001_gene244	1.597e-109	368.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
LZS3_k127_7004415_10	1379698.RBG1_1C00001G0191	1.399e-14	79.0	COG0816@1|root,COG0816@2|Bacteria,2NPSR@2323|unclassified Bacteria	2|Bacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
LZS3_k127_7004415_6	273068.TTE1255	3.716e-46	179.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,42G1M@68295|Thermoanaerobacterales	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
LZS3_k127_7004415_2	926550.CLDAP_08170	1.361e-128	419.0	COG1077@1|root,COG1077@2|Bacteria,2G62K@200795|Chloroflexi	200795|Chloroflexi	D	TIGRFAM cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
LZS3_k127_7004415_8	457570.Nther_0516	9.961e-30	128.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
LZS3_k127_7004415_3	926561.KB900617_gene1827	2.125e-115	395.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3WA9D@53433|Halanaerobiales	186801|Clostridia	M	Penicillin-binding protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
LZS3_k127_7004415_7	273068.TTE2373	5.713e-34	136.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,42G8G@68295|Thermoanaerobacterales	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
LZS3_k127_7004415_1	1120950.KB892707_gene4624	1.12e-143	471.0	COG1190@1|root,COG1190@2|Bacteria	2|Bacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567,ko:K04568	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03012,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
LZS3_k127_7004415_5	1089548.KI783301_gene3209	3.161e-100	340.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H9Y4@91061|Bacilli,3WDW8@539002|Bacillales incertae sedis	91061|Bacilli	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
LZS3_k127_730258_0	340099.Teth39_0342	1.173e-229	738.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
LZS3_k127_730258_1	349161.Dred_0756	2.498e-103	351.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,26071@186807|Peptococcaceae	186801|Clostridia	J	tRNA synthetase class II core domain (G, H, P, S and T)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
LZS3_k127_730258_3	945713.IALB_2279	1.753e-43	164.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	2.1.1.185,2.1.1.34	ko:K00556,ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase
LZS3_k127_730258_2	1410653.JHVC01000010_gene3575	1.254e-82	291.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
LZS3_k127_7503354_1	565033.GACE_0266	9.318e-70	246.0	arCOG07602@1|root,arCOG07602@2157|Archaea,2Y1QG@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7503354_0	1121890.AUDO01000011_gene398	1.101e-113	374.0	COG0668@1|root,COG0668@2|Bacteria,4NH7C@976|Bacteroidetes,1ICX5@117743|Flavobacteriia,2NVTM@237|Flavobacterium	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
LZS3_k127_7731174_6	234267.Acid_1496	1.846e-45	170.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria	57723|Acidobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
LZS3_k127_7731174_12	575540.Isop_0599	1.487e-19	99.0	COG2006@1|root,COG2006@2|Bacteria,2J2FX@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
LZS3_k127_7731174_3	1122947.FR7_3972	2.714e-72	254.0	COG3634@1|root,COG3634@2|Bacteria,1TPYN@1239|Firmicutes,4H46S@909932|Negativicutes	909932|Negativicutes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
LZS3_k127_7731174_5	635013.TherJR_2420	1.797e-51	198.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia	186801|Clostridia	D	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
LZS3_k127_7731174_0	1122939.ATUD01000009_gene3027	8.996e-143	469.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4CPAA@84995|Rubrobacteria	84995|Rubrobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
LZS3_k127_7731174_10	1121929.KB898664_gene1292	6.907e-25	114.0	COG0741@1|root,COG0741@2|Bacteria,1V1SZ@1239|Firmicutes,4HHCT@91061|Bacilli	91061|Bacilli	M	peptidase	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SLT,SLT_2
LZS3_k127_7731174_13	1303518.CCALI_02533	9.86e-19	91.0	COG1451@1|root,COG1451@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF2786,DUF45,SprT-like
LZS3_k127_7731174_9	243164.DET0455	3.861e-33	132.0	COG0537@1|root,COG0537@2|Bacteria,2G6VV@200795|Chloroflexi,34DCM@301297|Dehalococcoidia	301297|Dehalococcoidia	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
LZS3_k127_7731174_7	1449063.JMLS01000008_gene4995	3.666e-36	143.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,4HIQP@91061|Bacilli,26WUI@186822|Paenibacillaceae	91061|Bacilli	S	Aspartyl-tRNA amidotransferase	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
LZS3_k127_7731174_4	1196031.ALEG01000061_gene2102	2.886e-54	202.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,4HAEZ@91061|Bacilli,1ZANS@1386|Bacillus	91061|Bacilli	S	membrane-associated HD superfamily hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
LZS3_k127_7731174_14	1460635.JCM19038_135	2.613e-16	84.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,4HIIE@91061|Bacilli	91061|Bacilli	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
LZS3_k127_7731174_16	1408424.JHYI01000004_gene3425	1.241e-13	75.0	COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,4HNKN@91061|Bacilli,1ZHW0@1386|Bacillus	91061|Bacilli	M	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS07900	DAGK_prokar
LZS3_k127_7731174_2	1382306.JNIM01000001_gene41	7.28e-95	325.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
LZS3_k127_7731174_1	555088.DealDRAFT_1341	6.546e-136	442.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,42JIC@68298|Syntrophomonadaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
LZS3_k127_7731174_8	526218.Sterm_1574	6.351e-34	135.0	COG1327@1|root,COG1327@2|Bacteria,37AGD@32066|Fusobacteria	32066|Fusobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
LZS3_k127_7731174_11	1379698.RBG1_1C00001G1849	1.305e-22	101.0	COG3118@1|root,COG3118@2|Bacteria,2NPNZ@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
LZS3_k127_7731174_15	699246.HMPREF0868_0495	1.192e-14	74.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,267U0@186813|unclassified Clostridiales	186801|Clostridia	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
LZS3_k127_7737882_2	767029.HMPREF9154_0593	1.723e-06	55.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria,4DS5K@85009|Propionibacteriales	201174|Actinobacteria	D	Septum formation initiator	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
LZS3_k127_7737882_4	1463861.JNXE01000003_gene3919	0.0002313	54.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C
LZS3_k127_7737882_0	1391646.AVSU01000094_gene312	9.598e-22	102.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,25RJ3@186804|Peptostreptococcaceae	186801|Clostridia	G	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
LZS3_k127_7737882_1	525904.Tter_0042	7.673e-15	87.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	enhA_1	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
LZS3_k127_7766361_12	36914.XP_001523559.1	3.902e-08	57.0	COG0203@1|root,KOG3280@2759|Eukaryota,3A3E6@33154|Opisthokonta,3P663@4751|Fungi,3QY13@4890|Ascomycota,3RXM4@4891|Saccharomycetes,47AW0@766764|Debaryomycetaceae	4751|Fungi	J	ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L17
LZS3_k127_7766361_7	868864.Dester_1257	2.601e-41	156.0	COG0102@1|root,COG0102@2|Bacteria,2G3Z9@200783|Aquificae	200783|Aquificae	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
LZS3_k127_7766361_8	525904.Tter_0746	1.634e-31	127.0	COG0103@1|root,COG0103@2|Bacteria,2NPN8@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
LZS3_k127_7766361_13	1208919.CDSE_0677	0.0002651	49.0	COG0858@1|root,COG0858@2|Bacteria,1PXYP@1224|Proteobacteria,2VVBI@28216|Betaproteobacteria,1KR94@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
LZS3_k127_7766361_3	391009.Tmel_1045	1.487e-77	265.0	COG0016@1|root,COG0016@2|Bacteria,2GCC2@200918|Thermotogae	200918|Thermotogae	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
LZS3_k127_7766361_1	639282.DEFDS_1621	4.031e-136	460.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GEYD@200930|Deferribacteres	200930|Deferribacteres	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
LZS3_k127_7766361_2	1078083.HMPREF1208_01006	1.345e-122	408.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,4HACD@91061|Bacilli,4GXD4@90964|Staphylococcaceae	91061|Bacilli	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
LZS3_k127_7766361_5	189426.PODO_00510	2.451e-47	178.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4HAVS@91061|Bacilli,26R6G@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21	ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
LZS3_k127_7766361_6	2325.TKV_c12510	1.379e-45	177.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	dacB1	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
LZS3_k127_7766361_10	1123354.AUDR01000013_gene653	1.462e-22	104.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2VPCK@28216|Betaproteobacteria,1KSR1@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Guanylate kinase homologues.	-	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
LZS3_k127_7766361_4	656519.Halsa_1548	2.15e-52	193.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3WAJK@53433|Halanaerobiales	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
LZS3_k127_7766361_9	479434.Sthe_0377	9.103e-28	117.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi,27YFI@189775|Thermomicrobia	189775|Thermomicrobia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
LZS3_k127_7766361_11	526222.Desal_0663	6.072e-12	68.0	COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria,2MDD0@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
LZS3_k127_7766361_0	1347392.CCEZ01000043_gene227	7.854e-278	886.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,36DKN@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
LZS3_k127_7793_4	857293.CAAU_0236	5.848e-39	148.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02205	NTP_transferase
LZS3_k127_7793_1	990073.ATHU01000001_gene839	1.318e-100	336.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2YNDI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
LZS3_k127_7793_3	1321815.HMPREF9193_00697	1.76e-80	280.0	COG1216@1|root,COG1216@2|Bacteria,2J9Z1@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS3_k127_7793_7	290317.Cpha266_1381	2.815e-05	49.0	COG0864@1|root,COG0864@2|Bacteria	2|Bacteria	K	response to nickel cation	ndoAI	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07723	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
LZS3_k127_7793_8	671143.DAMO_1234	0.0005285	46.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
LZS3_k127_7793_6	933262.AXAM01000070_gene2275	1.26e-11	67.0	COG1569@1|root,COG1569@2|Bacteria,1Q9X8@1224|Proteobacteria,431MF@68525|delta/epsilon subdivisions,2WWQP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
LZS3_k127_7793_5	1120951.AUBG01000003_gene2826	2.399e-24	106.0	COG0614@1|root,COG0614@2|Bacteria,4NRGG@976|Bacteroidetes,1IJ3X@117743|Flavobacteriia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_7793_0	1321815.HMPREF9193_00696	8.227e-190	606.0	COG1032@1|root,COG1032@2|Bacteria,2J9G9@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
LZS3_k127_7793_2	1131269.AQVV01000009_gene1088	3.135e-96	323.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS3_k127_7959743_0	1246626.BleG1_3959	1.393e-153	501.0	COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,1UXWV@1239|Firmicutes,4HWP0@91061|Bacilli	91061|Bacilli	V	type I restriction modification DNA specificity domain	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
LZS3_k127_8113611_3	574087.Acear_1960	3.614e-89	308.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3WA5R@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
LZS3_k127_8113611_7	224325.AF_0565	2.031e-36	142.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
LZS3_k127_8113611_0	457570.Nther_0302	1.233e-123	410.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
LZS3_k127_8113611_4	237368.SCABRO_01703	3.268e-67	237.0	COG0084@1|root,COG0535@1|root,COG0084@2|Bacteria,COG0535@2|Bacteria,2IZ3Q@203682|Planctomycetes	203682|Planctomycetes	L	COG0084 Mg-dependent DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
LZS3_k127_8113611_8	877418.ATWV01000001_gene1449	7.974e-31	124.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
LZS3_k127_8113611_1	639282.DEFDS_0066	1.752e-122	409.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2GF31@200930|Deferribacteres	200930|Deferribacteres	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
LZS3_k127_8113611_9	1348114.OM33_05370	1.542e-17	89.0	COG0454@1|root,COG0454@2|Bacteria,1RE63@1224|Proteobacteria,1S3TS@1236|Gammaproteobacteria,2Q24Z@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
LZS3_k127_8113611_6	1338011.BD94_0002	1.359e-53	198.0	COG0313@1|root,COG0313@2|Bacteria,4NFQM@976|Bacteroidetes,1HX5Y@117743|Flavobacteriia,34PQJ@308865|Elizabethkingia	976|Bacteroidetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
LZS3_k127_8113611_2	1476583.DEIPH_ctg139orf0031	3.092e-110	373.0	COG1914@1|root,COG1914@2|Bacteria,1WM66@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
LZS3_k127_8113611_5	243164.DET0404	1.555e-63	228.0	COG0030@1|root,COG0030@2|Bacteria,2G6ER@200795|Chloroflexi,34CIF@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
LZS3_k127_8113611_10	1381123.AYOD01000035_gene3754	2.753e-06	59.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2UBTC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
LZS3_k127_8239152_10	673860.AciM339_1173	2.226e-08	58.0	COG0298@1|root,arCOG04427@2157|Archaea,2Y0AJ@28890|Euryarchaeota,3F2UW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
LZS3_k127_8239152_1	43354.JOIJ01000002_gene4364	6.13e-108	359.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4DYE3@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
LZS3_k127_8239152_5	373903.Hore_15810	3.448e-59	213.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,3WAKR@53433|Halanaerobiales	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS19265	TIM
LZS3_k127_8239152_2	1293054.HSACCH_02119	8.385e-75	263.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,248G0@186801|Clostridia,3WACN@53433|Halanaerobiales	186801|Clostridia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
LZS3_k127_8239152_3	1033737.CAEV01000060_gene3596	1.589e-64	237.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,36DMH@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
LZS3_k127_8239152_0	1541960.KQ78_00792	4.811e-118	392.0	COG0442@1|root,COG0442@2|Bacteria,3WV4I@544448|Tenericutes	544448|Tenericutes	J	Anticodon binding domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
LZS3_k127_8239152_6	1293054.HSACCH_01186	8.869e-59	217.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WAGW@53433|Halanaerobiales	186801|Clostridia	M	PDZ domain (Also known as DHR or GLGF)	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
LZS3_k127_8239152_8	744872.Spica_1417	1.31e-50	186.0	COG0233@1|root,COG0233@2|Bacteria,2J6PZ@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
LZS3_k127_8239152_4	1121289.JHVL01000003_gene2194	2.253e-62	220.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,36DEJ@31979|Clostridiaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
LZS3_k127_8239152_7	1229276.DI53_2376	2.235e-56	207.0	COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes,1IQSP@117747|Sphingobacteriia	976|Bacteroidetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
LZS3_k127_8239152_9	1304865.JAGF01000001_gene2445	2.106e-45	176.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
LZS3_k127_8239152_11	644966.Tmar_0363	1.232e-06	50.0	COG3464@1|root,COG3464@2|Bacteria,1TQ93@1239|Firmicutes,24AMP@186801|Clostridia,3WDCW@538999|Clostridiales incertae sedis	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
LZS3_k127_8262187_5	161156.JQKW01000007_gene657	2.131e-63	226.0	COG1943@1|root,COG1943@2|Bacteria,2GI5R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
LZS3_k127_8262187_23	1408823.AXUS01000011_gene2109	6.961e-13	72.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,25RPG@186804|Peptostreptococcaceae	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
LZS3_k127_8262187_0	796940.HMPREF9628_00340	4.303e-287	897.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,25QN5@186804|Peptostreptococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
LZS3_k127_8262187_1	1279015.KB908458_gene2480	3.791e-188	595.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1Y3XP@135624|Aeromonadales	135624|Aeromonadales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
LZS3_k127_8262187_12	1132442.KB889752_gene3453	3.435e-42	156.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,4HIKH@91061|Bacilli,1ZGA6@1386|Bacillus	91061|Bacilli	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
LZS3_k127_8262187_10	1423321.AS29_07640	3.018e-43	165.0	COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,4HAEN@91061|Bacilli,1ZCM8@1386|Bacillus	91061|Bacilli	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0008150,GO:0009893,GO:0010468,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0044087,GO:0044089,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090070,GO:2000232,GO:2000234	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
LZS3_k127_8262187_15	553220.CAMGR0001_0649	1.204e-32	134.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,42MPW@68525|delta/epsilon subdivisions,2YMU6@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
LZS3_k127_8262187_22	648757.Rvan_2982	5.771e-13	73.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria,3N759@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
LZS3_k127_8262187_3	879309.HMPREF9199_1565	4.376e-87	295.0	COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,4H3E9@909932|Negativicutes	909932|Negativicutes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
LZS3_k127_8262187_14	575540.Isop_2083	1.427e-33	132.0	COG0185@1|root,COG0185@2|Bacteria,2J0BB@203682|Planctomycetes	203682|Planctomycetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
LZS3_k127_8262187_26	1122129.AUEF01000011_gene1275	3.953e-10	66.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,4HIK2@91061|Bacilli,4GZ52@90964|Staphylococcaceae	91061|Bacilli	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
LZS3_k127_8262187_6	661367.LLO_0492	8.533e-56	202.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1JC6S@118969|Legionellales	118969|Legionellales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
LZS3_k127_8262187_7	111780.Sta7437_4095	6.611e-53	189.0	COG0197@1|root,COG0197@2|Bacteria,1G55B@1117|Cyanobacteria,3VJMQ@52604|Pleurocapsales	1117|Cyanobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
LZS3_k127_8262187_24	335283.Neut_0567	9.054e-13	71.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,373HA@32003|Nitrosomonadales	28216|Betaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
LZS3_k127_8262187_13	869210.Marky_1716	2.833e-41	154.0	COG0093@1|root,COG0093@2|Bacteria,1WJSD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
LZS3_k127_8262187_18	1338011.BD94_3649	2.306e-23	105.0	COG0198@1|root,COG0198@2|Bacteria,4NSTI@976|Bacteroidetes,1I2VR@117743|Flavobacteriia,34RKG@308865|Elizabethkingia	976|Bacteroidetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
LZS3_k127_8262187_11	110663.KI911558_gene2356	1.462e-42	162.0	COG0094@1|root,COG0094@2|Bacteria,1FZW3@1117|Cyanobacteria,1GYK8@1129|Synechococcus	1117|Cyanobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
LZS3_k127_8262187_19	760011.Spico_1703	3.287e-23	99.0	COG0199@1|root,COG0199@2|Bacteria,2J8U1@203691|Spirochaetes	203691|Spirochaetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
LZS3_k127_8262187_16	413404.Rmag_0179	1.934e-30	124.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1J6AP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
LZS3_k127_8262187_9	91464.S7335_4853	7.115e-44	166.0	COG0097@1|root,COG0097@2|Bacteria,1G4ZT@1117|Cyanobacteria,1GYYV@1129|Synechococcus	1117|Cyanobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
LZS3_k127_8262187_21	1120978.KB894084_gene350	2.541e-21	97.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,4HIGF@91061|Bacilli,27GH4@186828|Carnobacteriaceae	91061|Bacilli	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
LZS3_k127_8262187_8	1410674.JNKU01000032_gene1088	7.762e-46	173.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,4HFN4@91061|Bacilli,3F3VY@33958|Lactobacillaceae	91061|Bacilli	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
LZS3_k127_8262187_20	1094508.Tsac_1030	5.73e-22	101.0	COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,42G84@68295|Thermoanaerobacterales	186801|Clostridia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
LZS3_k127_8262187_2	309801.trd_0965	8.8e-111	372.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi,27XI1@189775|Thermomicrobia	189775|Thermomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
LZS3_k127_8262187_17	1291050.JAGE01000001_gene2112	4.311e-28	121.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3WHQ6@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
LZS3_k127_8262187_4	867903.ThesuDRAFT_00580	1.444e-71	249.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WCH7@538999|Clostridiales incertae sedis	186801|Clostridia	E	Metallopeptidase family M24	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
LZS3_k127_8292244_4	86416.Clopa_4450	3.045e-07	59.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,36FAH@31979|Clostridiaceae	186801|Clostridia	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
LZS3_k127_8292244_3	1123230.ARQJ01000024_gene773	1.348e-18	98.0	COG1388@1|root,COG3942@1|root,COG1388@2|Bacteria,COG3942@2|Bacteria,1V8WM@1239|Firmicutes,4I27S@91061|Bacilli,4GX44@90964|Staphylococcaceae	91061|Bacilli	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,LysM
LZS3_k127_8292244_1	205920.ECH_0543	4.089e-90	306.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,47F1I@766|Rickettsiales	766|Rickettsiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
LZS3_k127_8292244_2	710393.HSUHS1_0450	2.668e-35	142.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2YMSY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Co-chaperone-curved DNA binding protein A	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
LZS3_k127_8292244_0	1232437.KL662016_gene1095	2.121e-257	809.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
LZS3_k127_8292244_5	644966.Tmar_0363	1.232e-06	50.0	COG3464@1|root,COG3464@2|Bacteria,1TQ93@1239|Firmicutes,24AMP@186801|Clostridia,3WDCW@538999|Clostridiales incertae sedis	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
LZS3_k127_8392532_1	1089548.KI783301_gene699	7.56e-43	169.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,4H9ZW@91061|Bacilli,3WE2J@539002|Bacillales incertae sedis	91061|Bacilli	S	DHHA1 domain	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
LZS3_k127_8392532_2	525904.Tter_0072	4.6e-19	93.0	COG2220@1|root,COG2220@2|Bacteria,2NR9T@2323|unclassified Bacteria	2|Bacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
LZS3_k127_8392532_0	502558.EGYY_05950	1.164e-66	244.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CV59@84998|Coriobacteriia	84998|Coriobacteriia	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
LZS3_k127_8392532_3	616991.JPOO01000001_gene3525	5.068e-17	83.0	COG2827@1|root,COG2827@2|Bacteria,4NUN3@976|Bacteroidetes,1I6GH@117743|Flavobacteriia	976|Bacteroidetes	L	GIY-YIG catalytic domain	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
LZS3_k127_8392532_4	387631.Asulf_00452	1.457e-14	76.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
LZS3_k127_8406866_1	525898.Sdel_1531	2.823e-85	289.0	28IMK@1|root,2Z8N2@2|Bacteria,1R85A@1224|Proteobacteria	1224|Proteobacteria	L	Dam-replacing family	-	-	3.1.21.4	ko:K01155	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DpnI
LZS3_k127_8406866_5	459349.CLOAM1329	9.112e-22	96.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,2NQUB@2323|unclassified Bacteria	2|Bacteria	L	DNA methylase	dpnA	-	2.1.1.72	ko:K00571,ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
LZS3_k127_8406866_4	555079.Toce_1756	4.361e-25	110.0	2ARWP@1|root,31H8I@2|Bacteria,1V6GW@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_8406866_3	1121874.KB892378_gene770	2.131e-28	121.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,3VRIZ@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
LZS3_k127_8406866_6	327277.JHAL01000002_gene154	5.316e-14	81.0	COG3764@1|root,COG3764@2|Bacteria,2GNWT@201174|Actinobacteria,4CZMM@85004|Bifidobacteriales	201174|Actinobacteria	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
LZS3_k127_8406866_0	1280680.AUJU01000002_gene830	7.509e-146	480.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,4BW6G@830|Butyrivibrio	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
LZS3_k127_8406866_2	1382304.JNIL01000001_gene2897	1.766e-36	149.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,4HBTQ@91061|Bacilli,2784V@186823|Alicyclobacillaceae	91061|Bacilli	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050789,GO:0050793,GO:0051186,GO:0051188,GO:0055086,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
LZS3_k127_8448203_3	484019.THA_914	9.257e-16	81.0	COG0621@1|root,COG0621@2|Bacteria,2GCGZ@200918|Thermotogae	200918|Thermotogae	J	MiaB-like tRNA modifying enzyme	-	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
LZS3_k127_8448203_1	926692.AZYG01000007_gene1294	4.506e-69	265.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WAEK@53433|Halanaerobiales	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
LZS3_k127_8448203_0	865861.AZSU01000003_gene2059	2.58e-129	424.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,36E45@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
LZS3_k127_8448203_4	1242864.D187_002897	7.689e-06	58.0	COG4733@1|root,COG4733@2|Bacteria,1N010@1224|Proteobacteria,42M7U@68525|delta/epsilon subdivisions,2WRUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Fibronectin, type III domain	-	-	3.2.1.4	ko:K01179,ko:K06882	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	fn3
LZS3_k127_8448203_6	986075.CathTA2_2484	0.0002032	51.0	COG3327@1|root,COG3327@2|Bacteria,1TRBU@1239|Firmicutes,4HCP9@91061|Bacilli	91061|Bacilli	K	Phenylacetic acid degradation operon negative regulatory protein PaaX	paaX	-	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
LZS3_k127_8448203_2	443143.GM18_1541	6.155e-16	89.0	COG1409@1|root,COG3204@1|root,COG1409@2|Bacteria,COG3204@2|Bacteria,1N85S@1224|Proteobacteria,42WZ6@68525|delta/epsilon subdivisions,2WT5K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_C,PKD,Pur_ac_phosph_N
LZS3_k127_8493644_1	572477.Alvin_0807	4.875e-20	91.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,1WY2T@135613|Chromatiales	135613|Chromatiales	C	PFAM Nickel-dependent hydrogenase, large subunit	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
LZS3_k127_8493644_0	485913.Krac_10032	4.798e-74	259.0	COG1131@1|root,COG1131@2|Bacteria,2G5QI@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS3_k127_8493644_2	797209.ZOD2009_10725	1.874e-09	68.0	arCOG08617@1|root,arCOG08617@2157|Archaea,2XW39@28890|Euryarchaeota,23SYN@183963|Halobacteria	183963|Halobacteria	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
LZS3_k127_8529957_9	1123035.ARLA01000018_gene1642	5.056e-18	85.0	COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia,4C3E3@83612|Psychroflexus	976|Bacteroidetes	I	NUDIX domain	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
LZS3_k127_8529957_6	203119.Cthe_0231	1.054e-25	119.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3WK9K@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM
LZS3_k127_8529957_11	290402.Cbei_3514	2.482e-08	62.0	2DM42@1|root,31MY3@2|Bacteria,1V2GS@1239|Firmicutes,24EJE@186801|Clostridia,36GCD@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
LZS3_k127_8529957_10	1499689.CCNN01000007_gene1977	5.589e-18	90.0	COG1670@1|root,COG1670@2|Bacteria,1VAQ4@1239|Firmicutes,24IM9@186801|Clostridia,36M79@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
LZS3_k127_8529957_7	743719.PaelaDRAFT_2216	5.746e-25	110.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,26X19@186822|Paenibacillaceae	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
LZS3_k127_8529957_13	1120985.AUMI01000017_gene2673	0.0001671	49.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,4H53N@909932|Negativicutes	909932|Negativicutes	S	TrpR family protein YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
LZS3_k127_8529957_5	858215.Thexy_1526	8.657e-39	163.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,42F11@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
LZS3_k127_8529957_4	203119.Cthe_2752	5.966e-40	159.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WIY7@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
LZS3_k127_8529957_12	6087.XP_002159822.2	9.668e-06	53.0	COG0666@1|root,KOG0510@2759|Eukaryota,38G7Q@33154|Opisthokonta,3BCDU@33208|Metazoa	33208|Metazoa	DZ	osmolarity-sensing cation channel activity	-	-	-	ko:K04984	ko04750,map04750	-	-	-	ko00000,ko00001,ko04040	1.A.4.6.1,1.A.4.6.2,1.A.4.6.3,1.A.4.6.5	-	-	Ank_2,Ank_4,Ion_trans
LZS3_k127_8529957_2	383372.Rcas_0718	5.462e-59	212.0	COG0217@1|root,COG0217@2|Bacteria,2G6AI@200795|Chloroflexi,375BW@32061|Chloroflexia	32061|Chloroflexia	K	transcriptional regulatory protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
LZS3_k127_8529957_8	1250006.JHZZ01000001_gene2667	2.057e-21	99.0	COG0614@1|root,COG0614@2|Bacteria,4PK1S@976|Bacteroidetes,1IME4@117743|Flavobacteriia,3VXES@52959|Polaribacter	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_8529957_3	941824.TCEL_00388	2.339e-54	195.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,36J15@31979|Clostridiaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
LZS3_k127_8529957_1	247490.KSU1_A0088	6.699e-66	237.0	COG1085@1|root,COG1085@2|Bacteria,2IX2C@203682|Planctomycetes	203682|Planctomycetes	C	galactose-1-phosphate uridylyltransferase	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf,HIT
LZS3_k127_8529957_0	864702.OsccyDRAFT_2725	3.903e-71	256.0	COG0438@1|root,COG0438@2|Bacteria,1G1UM@1117|Cyanobacteria,1H9FF@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	spsB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_8764850_2	289376.THEYE_A1854	5.686e-59	216.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
LZS3_k127_8764850_10	1046627.BZARG_963	1.822e-17	86.0	COG0614@1|root,COG0614@2|Bacteria,4NS4Q@976|Bacteroidetes,1I3MV@117743|Flavobacteriia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_8764850_5	529709.PYCH_00040	2.512e-42	164.0	COG1941@1|root,arCOG02472@2157|Archaea,2XW80@28890|Euryarchaeota,245C3@183968|Thermococci	183968|Thermococci	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.12.1.3,1.12.1.5	ko:K17994	ko00920,map00920	-	R10390	-	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
LZS3_k127_8764850_4	1430440.MGMSRv2_1307	4.742e-54	199.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2V6M0@28211|Alphaproteobacteria,2JQRT@204441|Rhodospirillales	204441|Rhodospirillales	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
LZS3_k127_8764850_8	1123325.JHUV01000008_gene518	3.722e-31	135.0	COG1453@1|root,COG1453@2|Bacteria,2G460@200783|Aquificae	200783|Aquificae	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
LZS3_k127_8764850_0	580327.Tthe_2020	6.064e-98	332.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
LZS3_k127_8764850_1	697303.Thewi_0148	2.443e-64	231.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,42EMP@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM ketose-bisphosphate aldolase, class-II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
LZS3_k127_8764850_9	1168034.FH5T_10405	1.979e-20	96.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,2FTYU@200643|Bacteroidia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
LZS3_k127_8764850_7	349521.HCH_06817	2.121e-34	145.0	COG0524@1|root,COG0524@2|Bacteria,1QTMT@1224|Proteobacteria,1S1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
LZS3_k127_8764850_3	868131.MSWAN_1538	6.647e-58	211.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
LZS3_k127_8764850_6	68170.KL590490_gene1267	1.61e-39	170.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
LZS3_k127_943173_9	1336241.JAEB01000003_gene382	1.483e-13	80.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,25W2Z@186806|Eubacteriaceae	186801|Clostridia	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
LZS3_k127_943173_7	883156.HMPREF9282_01167	1.342e-53	198.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H1Y8@909932|Negativicutes	909932|Negativicutes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
LZS3_k127_943173_3	1279017.AQYJ01000024_gene861	3.996e-132	442.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,46433@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
LZS3_k127_943173_0	632518.Calow_0007	1.532e-258	829.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,42FIB@68295|Thermoanaerobacterales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
LZS3_k127_943173_1	350688.Clos_0006	4.368e-240	760.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,36DYE@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
LZS3_k127_943173_11	979556.MTES_0927	1.06e-05	59.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria,4FKVI@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
LZS3_k127_943173_5	932678.THERU_01915	8.65e-85	297.0	COG0732@1|root,COG0732@2|Bacteria	2|Bacteria	V	type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
LZS3_k127_943173_10	764298.STRMA_0741	3.716e-11	73.0	28I7P@1|root,2Z8AJ@2|Bacteria,1V4JU@1239|Firmicutes,4HIX9@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
LZS3_k127_943173_2	1216362.B437_10737	4.728e-157	518.0	COG0286@1|root,COG0286@2|Bacteria,37CGU@32066|Fusobacteria	32066|Fusobacteria	V	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2,N6_Mtase
LZS3_k127_943173_8	626369.HMPREF0446_00587	2.824e-30	128.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,4HBHA@91061|Bacilli,27FZF@186828|Carnobacteriaceae	91061|Bacilli	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
LZS3_k127_943173_4	580331.Thit_0645	6.986e-106	354.0	COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,24ARN@186801|Clostridia,42I34@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_943173_6	1408321.JNJD01000010_gene1448	6.562e-79	276.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,27IC2@186928|unclassified Lachnospiraceae	186801|Clostridia	M	CoA-binding domain	-	-	2.7.8.6	ko:K00996	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Bac_transf,CoA_binding_3
## 635 queries scanned
## Total time (seconds): 108.45403790473938
## Rate: 5.86 q/s