## Thu Oct 17 09:09:26 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/LZS3_bin.16.fa -m mmseqs --itype genome -o LZS3_bin.16 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/LZS3_bin.16 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
LZS3_k127_1275190_30	211586.SO_0189	1.036e-06	62.0	COG3637@1|root,COG3637@2|Bacteria,1QVUE@1224|Proteobacteria,1T2J5@1236|Gammaproteobacteria,2QETC@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,fn3
LZS3_k127_1275190_31	1122176.KB903570_gene4799	5.464e-06	59.0	COG3227@1|root,COG4935@1|root,COG3227@2|Bacteria,COG4935@2|Bacteria,4PPGZ@976|Bacteroidetes	976|Bacteroidetes	O	Metallo-peptidase family M12	-	-	-	-	-	-	-	-	-	-	-	-	CUB,Reprolysin_5
LZS3_k127_1275190_20	880073.Calab_0825	8.209e-15	90.0	COG1404@1|root,COG3637@1|root,COG1404@2|Bacteria,COG3637@2|Bacteria,2NPDC@2323|unclassified Bacteria	2|Bacteria	O	Peptidase S8	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	DUF3138,Peptidase_S8
LZS3_k127_1275190_15	553177.CAPSP0001_2249	5.35e-18	98.0	COG3391@1|root,COG4935@1|root,COG3391@2|Bacteria,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia,1ER48@1016|Capnocytophaga	976|Bacteroidetes	O	Thrombospondin type 3	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,P_proprotein,Reprolysin_4,TSP_3
LZS3_k127_1275190_1	390236.BafPKo_0173	7.31e-89	304.0	COG0714@1|root,COG0714@2|Bacteria,2J5VG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
LZS3_k127_1275190_10	1121930.AQXG01000003_gene2610	3.805e-38	155.0	COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,1IR6K@117747|Sphingobacteriia	976|Bacteroidetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
LZS3_k127_1275190_14	28042.GU90_13110	4.102e-21	104.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4DYPB@85010|Pseudonocardiales	201174|Actinobacteria	S	von Willebrand factor, type A	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
LZS3_k127_1275190_2	224324.aq_841	4.167e-66	239.0	COG1867@1|root,COG1867@2|Bacteria	2|Bacteria	J	N(2),N(2)-dimethylguanosine tRNA methyltransferase	trm1	GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
LZS3_k127_1275190_33	314285.KT71_04480	0.0001156	53.0	COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,1J6AJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	extracellular nuclease	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	DUF3616,Endonuclease_1,Exo_endo_phos,LTD
LZS3_k127_1275190_24	313606.M23134_06916	1.269e-11	76.0	COG2304@1|root,COG3291@1|root,COG5184@1|root,COG2304@2|Bacteria,COG3291@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	colA	-	3.4.24.3	ko:K01387,ko:K07114,ko:K12287	-	-	-	-	ko00000,ko01000,ko01002,ko02000,ko02042,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	CHU_C,Cna_B,Glyco_hydro_cc,PKD,PPC,Peptidase_M9,Peptidase_M9_N,VWA,VWA_2
LZS3_k127_1275190_12	1094980.Mpsy_2810	3.261e-26	115.0	COG1238@1|root,arCOG03118@2157|Archaea	2157|Archaea	I	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
LZS3_k127_1275190_28	171693.BN988_01344	1.406e-08	65.0	COG3206@1|root,COG3206@2|Bacteria,1V8AX@1239|Firmicutes,4HCT2@91061|Bacilli	91061|Bacilli	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
LZS3_k127_1275190_3	263820.PTO0637	1.482e-62	219.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,242AD@183967|Thermoplasmata	183967|Thermoplasmata	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
LZS3_k127_1275190_35	89462.XP_006069476.1	0.0004809	47.0	KOG3649@1|root,KOG3649@2759|Eukaryota,3AAX4@33154|Opisthokonta,3BUT4@33208|Metazoa,3D99I@33213|Bilateria,48G4X@7711|Chordata,49D69@7742|Vertebrata,3JHVQ@40674|Mammalia	33208|Metazoa	S	Kazal-type serine protease inhibitor domain	Spink12	GO:0008150,GO:0009892,GO:0010605,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090	-	-	-	-	-	-	-	-	-	-	Kazal_1
LZS3_k127_1275190_19	420247.Msm_0602	7.397e-15	77.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,23P7D@183925|Methanobacteria	183925|Methanobacteria	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
LZS3_k127_1275190_29	192952.MM_2513	1.604e-07	54.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y736@28890|Euryarchaeota,2NBEG@224756|Methanomicrobia	224756|Methanomicrobia	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
LZS3_k127_1275190_0	1313293.BAN_0057400	1.262e-181	583.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
LZS3_k127_1275190_27	634498.mru_0238	1.274e-09	68.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23PMM@183925|Methanobacteria	183925|Methanobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1275190_23	351160.RCIX2513	1.109e-11	72.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_1275190_8	1408422.JHYF01000001_gene3022	4.403e-41	158.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
LZS3_k127_1275190_11	13035.Dacsa_3406	2.903e-36	143.0	COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
LZS3_k127_1275190_6	1210908.HSB1_44870	3.077e-43	171.0	COG0628@1|root,arCOG02642@2157|Archaea,2XT00@28890|Euryarchaeota,23TDZ@183963|Halobacteria	183963|Halobacteria	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
LZS3_k127_1275190_22	1121405.dsmv_3772	2.817e-13	79.0	COG1073@1|root,COG1073@2|Bacteria,1QUD5@1224|Proteobacteria	1224|Proteobacteria	S	Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4
LZS3_k127_1275190_4	1278073.MYSTI_05459	5.345e-49	185.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
LZS3_k127_1275190_25	887062.HGR_02768	2.269e-11	66.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2VVV9@28216|Betaproteobacteria,4AFPU@80864|Comamonadaceae	28216|Betaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
LZS3_k127_1275190_7	647113.Metok_0614	3.764e-43	173.0	COG1361@1|root,arCOG02079@2157|Archaea,2XV4F@28890|Euryarchaeota,23QFD@183939|Methanococci	183939|Methanococci	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1275190_5	243232.MJ_1562	6.791e-45	177.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,23Q9A@183939|Methanococci	183939|Methanococci	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
LZS3_k127_1275190_9	243232.MJ_1562	1.214e-40	167.0	COG1033@1|root,arCOG02174@2157|Archaea,2XT5A@28890|Euryarchaeota,23Q9A@183939|Methanococci	183939|Methanococci	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
LZS3_k127_1275190_17	647113.Metok_0429	2.545e-16	83.0	COG3355@1|root,arCOG02242@2157|Archaea,2XY1Y@28890|Euryarchaeota,23R13@183939|Methanococci	183939|Methanococci	K	PFAM Transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
LZS3_k127_1275190_32	1031288.AXAA01000001_gene2225	0.0001062	51.0	2DGW3@1|root,2ZXGX@2|Bacteria,1W5JJ@1239|Firmicutes,255BB@186801|Clostridia,36TEJ@31979|Clostridiaceae	186801|Clostridia	S	Family of unknown function (DUF5320)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5320
LZS3_k127_1275190_21	311424.DhcVS_195	2.255e-14	79.0	COG1342@1|root,COG1342@2|Bacteria,2GAU3@200795|Chloroflexi,34DCF@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
LZS3_k127_1275190_26	1156844.KB891798_gene6534	4.965e-11	76.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_2,PGAP1
LZS3_k127_151774_1	706587.Desti_1267	4.137e-148	480.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MQAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
LZS3_k127_151774_4	693661.Arcve_1018	1.735e-99	340.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota	28890|Euryarchaeota	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
LZS3_k127_151774_17	339860.Msp_1156	6.633e-28	116.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,23P4M@183925|Methanobacteria	183925|Methanobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
LZS3_k127_151774_7	497964.CfE428DRAFT_6224	7.888e-87	308.0	COG1384@1|root,COG1384@2|Bacteria	2|Bacteria	J	tRNA binding	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
LZS3_k127_151774_22	797209.ZOD2009_04787	3.707e-14	78.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT6J@28890|Euryarchaeota,23SDS@183963|Halobacteria	183963|Halobacteria	H	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	RimK,Zn_protease
LZS3_k127_151774_13	1121921.KB898706_gene2882	1.311e-41	168.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,2PMSQ@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	Prokaryotic glutathione synthetase, ATP-grasp domain	rimK	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
LZS3_k127_151774_16	35841.BT1A1_0742	2.395e-28	118.0	COG0537@1|root,COG0537@2|Bacteria,1V2XA@1239|Firmicutes,4HGAH@91061|Bacilli,1ZFT0@1386|Bacillus	91061|Bacilli	FG	adenosine 5'-monophosphoramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_151774_25	192952.MM_2527	1.719e-09	63.0	arCOG01059@1|root,arCOG01059@2157|Archaea,2Y0H1@28890|Euryarchaeota,2N9Y0@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_151774_11	269797.Mbar_A2092	1.19e-56	206.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,2NBIC@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions in trans to edit the amino acid moiety from	alaXM	GO:0002161,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A2092	tRNA-synt_2c,tRNA_SAD
LZS3_k127_151774_6	622637.KE124774_gene1190	5.66e-88	304.0	COG0695@1|root,COG0695@2|Bacteria,1QVSK@1224|Proteobacteria,2UB2Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_151774_8	247490.KSU1_C1187	1.229e-76	264.0	COG0177@1|root,COG0177@2|Bacteria,2IZVV@203682|Planctomycetes	203682|Planctomycetes	L	PFAM HhH-GPD superfamily base excision DNA repair protein	-	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
LZS3_k127_151774_23	1173026.Glo7428_0554	3.74e-13	76.0	COG2940@1|root,COG2940@2|Bacteria	2|Bacteria	K	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
LZS3_k127_151774_21	420247.Msm_0462	4.44e-17	88.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,23PNK@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Mov34 MPN PAD-1	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
LZS3_k127_151774_28	1056820.KB900630_gene1381	9.404e-05	53.0	COG1226@1|root,2Z7ZD@2|Bacteria,1MXKM@1224|Proteobacteria,1RNMT@1236|Gammaproteobacteria,2PMUS@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	P	Polycystin cation channel	-	-	-	ko:K08714	-	-	-	-	ko00000,ko02000	1.A.1.14	-	-	Ion_trans
LZS3_k127_151774_14	420247.Msm_0989	1.187e-38	150.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23P09@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
LZS3_k127_151774_12	272844.PAB0558	1.327e-48	186.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2433Q@183968|Thermococci	183968|Thermococci	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
LZS3_k127_151774_18	572546.Arcpr_0876	8.034e-26	111.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2470Y@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
LZS3_k127_151774_3	665571.STHERM_c10230	3.355e-126	425.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
LZS3_k127_151774_9	573064.Mefer_0296	1.11e-63	225.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,23QDG@183939|Methanococci	183939|Methanococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C,Intein_splicing,LAGLIDADG_3
LZS3_k127_151774_15	224325.AF_1598	2.031e-33	131.0	arCOG06137@1|root,arCOG06137@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234
LZS3_k127_151774_24	1077285.AGDG01000039_gene3997	3.006e-12	71.0	COG4640@1|root,COG4640@2|Bacteria,4PIJG@976|Bacteroidetes,2FTJN@200643|Bacteroidia,4ATWX@815|Bacteroidaceae	976|Bacteroidetes	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
LZS3_k127_151774_20	1209072.ALBT01000047_gene463	9.376e-19	98.0	2EPTW@1|root,33HED@2|Bacteria,1NK6N@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_151774_19	444158.MmarC6_1056	2.247e-20	96.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,23R6Q@183939|Methanococci	183939|Methanococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
LZS3_k127_151774_29	765177.Desmu_1243	0.000228	46.0	COG1383@1|root,arCOG01885@2157|Archaea,2XR16@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
LZS3_k127_151774_10	1297742.A176_02411	4.881e-62	228.0	COG0477@1|root,COG2814@2|Bacteria,1R590@1224|Proteobacteria,42P8I@68525|delta/epsilon subdivisions	1224|Proteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
LZS3_k127_151774_5	926561.KB900617_gene1766	1.092e-91	316.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WAE6@53433|Halanaerobiales	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
LZS3_k127_151774_0	858215.Thexy_0817	4.021e-163	529.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,42FP5@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
LZS3_k127_151774_2	195522.BD01_1864	9.035e-133	437.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,243MB@183968|Thermococci	183968|Thermococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
LZS3_k127_151774_26	523850.TON_1677	5.412e-08	66.0	COG2064@1|root,arCOG01811@2157|Archaea,2Y68E@28890|Euryarchaeota,243AB@183968|Thermococci	183968|Thermococci	N	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
LZS3_k127_151774_27	1220534.B655_0321	3.243e-05	50.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y780@28890|Euryarchaeota,23P2D@183925|Methanobacteria	183925|Methanobacteria	N	type II secretion	gspF1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
LZS3_k127_1527066_17	1122994.AUFR01000022_gene334	9.662e-11	70.0	COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,4DR1C@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	padR	-	-	-	-	-	-	-	-	-	-	-	PadR
LZS3_k127_1527066_3	632292.Calhy_0462	8.523e-76	260.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,42G06@68295|Thermoanaerobacterales	186801|Clostridia	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS3_k127_1527066_13	1094980.Mpsy_1262	7.642e-17	93.0	arCOG02083@1|root,arCOG02083@2157|Archaea,2Y2FI@28890|Euryarchaeota,2NA9F@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1527066_14	1471522.JFNU01000106_gene757	7.707e-16	90.0	COG0577@1|root,COG0577@2|Bacteria,1G1W4@1117|Cyanobacteria,1MKDV@1212|Prochloraceae	1117|Cyanobacteria	V	Alternative locus ID	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS3_k127_1527066_4	243232.MJ_1507	1.772e-68	251.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23QAJ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
LZS3_k127_1527066_5	484019.THA_1285	1.462e-64	232.0	COG0037@1|root,COG0037@2|Bacteria,2GCKT@200918|Thermotogae	200918|Thermotogae	H	Belongs to the TtcA family	-	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
LZS3_k127_1527066_6	56110.Oscil6304_0064	4.502e-42	164.0	COG2856@1|root,COG2856@2|Bacteria,1G68Z@1117|Cyanobacteria,1HB8D@1150|Oscillatoriales	1117|Cyanobacteria	E	Putative metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4344
LZS3_k127_1527066_21	1123248.KB893316_gene4599	8.291e-07	64.0	COG1749@1|root,COG1749@2|Bacteria,4NTUT@976|Bacteroidetes	976|Bacteroidetes	N	Domain of unknown function (DUF4082)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4082
LZS3_k127_1527066_10	391625.PPSIR1_20754	1.153e-22	117.0	COG5184@1|root,COG5184@2|Bacteria,1QZTG@1224|Proteobacteria	2|Bacteria	DZ	Domain of unknown function (DUF4215)	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF4215,Fibrinogen_C,RCC1_2,TSP_3
LZS3_k127_1527066_7	1121904.ARBP01000006_gene3681	3.765e-28	135.0	COG3419@1|root,COG4447@1|root,COG4932@1|root,COG5184@1|root,COG3419@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NNEI@976|Bacteroidetes	976|Bacteroidetes	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF1566
LZS3_k127_1527066_16	1232449.BAHV02000001_gene316	2.766e-12	77.0	COG1278@1|root,COG1278@2|Bacteria	2|Bacteria	K	Cold shock	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
LZS3_k127_1527066_20	1151117.AJLF01000005_gene1788	6.203e-08	62.0	COG1437@1|root,arCOG01723@2157|Archaea,2Y3IM@28890|Euryarchaeota,2444J@183968|Thermococci	183968|Thermococci	F	CYTH	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
LZS3_k127_1527066_2	1142394.PSMK_02040	1.079e-92	314.0	COG0524@1|root,COG0524@2|Bacteria,2IXGC@203682|Planctomycetes	203682|Planctomycetes	H	PFAM PfkB	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
LZS3_k127_1527066_12	751944.HALDL1_06460	1.51e-18	96.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,23S6Y@183963|Halobacteria	183963|Halobacteria	K	Phosphate uptake regulator	phoU1	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
LZS3_k127_1527066_0	198467.NP92_12035	2.151e-260	817.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,21W43@150247|Anoxybacillus	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
LZS3_k127_1527066_1	456320.Mvol_0765	7.369e-190	619.0	COG0550@1|root,arCOG01305@1|root,arCOG01305@2157|Archaea,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,23QA8@183939|Methanococci	183939|Methanococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,Topoisom_bac,Toprim,zf-C4_Topoisom
LZS3_k127_1527066_22	523850.TON_1934	2.056e-06	53.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,242YS@183968|Thermococci	183968|Thermococci	J	Putative diphthamide synthesis protein	-	GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016765,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0048037,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0051536,GO:0051539,GO:0051540,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
LZS3_k127_1527066_18	391625.PPSIR1_14055	4.309e-08	64.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1QZT5@1224|Proteobacteria,42YUM@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1527066_25	204536.SULAZ_0986	2.618e-05	56.0	COG3267@1|root,COG3267@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,SPOR
LZS3_k127_1527066_11	416348.Hlac_0618	2.305e-21	103.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,23SNY@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
LZS3_k127_1527066_23	1121441.AUCX01000015_gene3465	4.03e-06	57.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QB7@68525|delta/epsilon subdivisions,2WM6Y@28221|Deltaproteobacteria,2M881@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
LZS3_k127_1527066_15	224719.Abm4_0917	5.019e-13	72.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,23P4A@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L37Ae	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
LZS3_k127_1527066_26	391623.TERMP_00166	0.0005401	43.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y5DR@28890|Euryarchaeota,245JP@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
LZS3_k127_1527066_19	1457250.BBMO01000002_gene2526	4.773e-08	59.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,23VTW@183963|Halobacteria	183963|Halobacteria	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
LZS3_k127_1527066_24	1229909.NSED_01480	4.406e-06	51.0	COG1698@1|root,arCOG04308@2157|Archaea,41SRP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
LZS3_k127_1527066_8	1094980.Mpsy_2452	1.479e-26	110.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y1DC@28890|Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM addiction module toxin, RelE StbE family	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ParE_toxin
LZS3_k127_1527066_9	1094980.Mpsy_2451	6.239e-23	99.0	arCOG09519@1|root,arCOG09519@2157|Archaea,2Y284@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_1647903_8	694429.Pyrfu_1090	3.095e-39	150.0	COG2220@1|root,arCOG00497@2157|Archaea,2XQFG@28889|Crenarchaeota	28889|Crenarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
LZS3_k127_1647903_9	1343739.PAP_09730	1.636e-37	161.0	COG1750@1|root,arCOG01937@2157|Archaea,2XUEB@28890|Euryarchaeota,242IS@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
LZS3_k127_1647903_10	1343739.PAP_02845	2.216e-35	142.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
LZS3_k127_1647903_14	323259.Mhun_3013	1.566e-05	52.0	COG2023@1|root,arCOG04345@2157|Archaea	2157|Archaea	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540,ko:K07574	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016	-	-	-	Rpr2
LZS3_k127_1647903_2	768670.Calni_1986	6.951e-139	460.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GENW@200930|Deferribacteres	200930|Deferribacteres	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
LZS3_k127_1647903_5	997346.HMPREF9374_0649	2.77e-85	291.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,4HAA4@91061|Bacilli,27BFJ@186824|Thermoactinomycetaceae	91061|Bacilli	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
LZS3_k127_1647903_12	444158.MmarC6_0933	2.904e-10	67.0	COG1374@1|root,arCOG00993@2157|Archaea,2XY2S@28890|Euryarchaeota,23R00@183939|Methanococci	183939|Methanococci	J	Uncharacterised protein family (UPF0113)	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
LZS3_k127_1647903_4	935948.KE386495_gene1721	6.739e-104	349.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
LZS3_k127_1647903_3	639282.DEFDS_1893	1.441e-131	427.0	COG0057@1|root,COG0057@2|Bacteria,2GEIF@200930|Deferribacteres	200930|Deferribacteres	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
LZS3_k127_1647903_0	879212.DespoDRAFT_00514	0.0	1093.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2MJ97@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
LZS3_k127_1647903_1	555088.DealDRAFT_1177	2.109e-242	767.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,42KC8@68298|Syntrophomonadaceae	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
LZS3_k127_1647903_11	1450694.BTS2_3383	6.858e-21	105.0	COG3177@1|root,COG3177@2|Bacteria,1TZWX@1239|Firmicutes,4HFD7@91061|Bacilli,1ZCEW@1386|Bacillus	91061|Bacilli	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,HTH_17
LZS3_k127_1647903_7	1286171.EAL2_808p05560	9.488e-40	167.0	COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,24EBQ@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
LZS3_k127_1647903_6	1232410.KI421413_gene750	2.791e-60	228.0	COG2885@1|root,COG3210@1|root,COG5184@1|root,COG5276@1|root,COG2885@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	DZ	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3
LZS3_k127_1779208_10	1254432.SCE1572_16230	1.766e-08	68.0	COG2133@1|root,COG2133@2|Bacteria,1PEJE@1224|Proteobacteria,437VF@68525|delta/epsilon subdivisions,2X352@28221|Deltaproteobacteria,2YUAU@29|Myxococcales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215,GSDH,Ig_3
LZS3_k127_1779208_4	572546.Arcpr_0362	1.788e-28	124.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
LZS3_k127_1779208_12	419665.Maeo_0704	9.429e-07	53.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,23RB1@183939|Methanococci	183939|Methanococci	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
LZS3_k127_1779208_1	439481.Aboo_1152	3.817e-47	179.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
LZS3_k127_1779208_7	573063.Metin_0775	1.863e-14	74.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23R97@183939|Methanococci	183939|Methanococci	J	PFAM Ribosomal protein S27E	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
LZS3_k127_1779208_9	1151117.AJLF01000001_gene1497	1.584e-08	60.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,244C9@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
LZS3_k127_1779208_11	304371.MCP_1538	9.74e-08	62.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
LZS3_k127_1779208_0	1042877.GQS_02700	1.487e-75	269.0	COG2100@1|root,arCOG00951@2157|Archaea,2XU1G@28890|Euryarchaeota,2439D@183968|Thermococci	183968|Thermococci	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06935	-	-	-	-	ko00000	-	-	-	Radical_SAM
LZS3_k127_1779208_13	529709.PYCH_07330	0.0007242	53.0	arCOG03418@1|root,arCOG03418@2157|Archaea,2XUAG@28890|Euryarchaeota,242UX@183968|Thermococci	183968|Thermococci	S	S-layer like family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	S_layer_C,S_layer_N
LZS3_k127_1779208_8	634498.mru_1281	2.309e-13	71.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
LZS3_k127_1779208_6	572546.Arcpr_0994	4.606e-18	86.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,246DE@183980|Archaeoglobi	183980|Archaeoglobi	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
LZS3_k127_1779208_3	1220534.B655_2348	1.097e-35	139.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,23P4U@183925|Methanobacteria	183925|Methanobacteria	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
LZS3_k127_1779208_5	679926.Mpet_2089	2.577e-23	106.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,2N9J9@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A2079	CBS,HTH_3
LZS3_k127_1779208_2	435591.BDI_2958	1.487e-45	169.0	COG4912@1|root,COG4912@2|Bacteria,4NKBS@976|Bacteroidetes,2FM3U@200643|Bacteroidia,22XNZ@171551|Porphyromonadaceae	976|Bacteroidetes	L	DNA alkylation repair	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
LZS3_k127_2084963_20	264462.Bd1712	1.43e-19	105.0	COG2911@1|root,COG2911@2|Bacteria,1QY25@1224|Proteobacteria,43C9F@68525|delta/epsilon subdivisions,2MUT5@213481|Bdellovibrionales,2X7JW@28221|Deltaproteobacteria	2|Bacteria	M	cell wall surface anchor family protein	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_1,CHU_C,Calx-beta,IAT_beta,Invasin_D3,Peptidase_S74
LZS3_k127_2084963_6	523845.AQXV01000048_gene602	2.346e-78	274.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota,23QB0@183939|Methanococci	183939|Methanococci	M	PFAM MscS Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
LZS3_k127_2084963_2	1280689.AUJC01000004_gene312	9.634e-109	364.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
LZS3_k127_2084963_5	573061.Clocel_1891	1.835e-81	282.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,36DRX@31979|Clostridiaceae	186801|Clostridia	C	phosphate acetyltransferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
LZS3_k127_2084963_4	1123242.JH636435_gene1529	2.397e-87	304.0	COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes	203682|Planctomycetes	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
LZS3_k127_2084963_16	1463936.JOJI01000024_gene1254	3.135e-46	182.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20	-	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
LZS3_k127_2084963_14	1410661.JNKW01000001_gene866	4.373e-54	202.0	COG0543@1|root,COG0543@2|Bacteria,1TQBZ@1239|Firmicutes,248GQ@186801|Clostridia	186801|Clostridia	C	Sulfite reductase Subunit B	asrB	-	-	ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
LZS3_k127_2084963_15	742818.HMPREF9451_01061	1.055e-50	193.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria,4CUEB@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
LZS3_k127_2084963_17	1304865.JAGF01000001_gene2445	1.03e-43	171.0	COG0697@1|root,COG0697@2|Bacteria,2IH82@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
LZS3_k127_2084963_21	536227.CcarbDRAFT_2035	1.128e-12	71.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
LZS3_k127_2084963_18	351160.RCIX2513	7.613e-20	97.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_2084963_13	945713.IALB_2285	1.87e-54	197.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
LZS3_k127_2084963_1	543526.Htur_2999	8.898e-109	364.0	COG0012@1|root,arCOG00357@2157|Archaea,2XV2N@28890|Euryarchaeota,23TCR@183963|Halobacteria	183963|Halobacteria	J	translation factor	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
LZS3_k127_2084963_11	273526.SMDB11_3949	4.624e-65	225.0	COG0537@1|root,COG0537@2|Bacteria,1R7GK@1224|Proteobacteria,1S0R0@1236|Gammaproteobacteria,402YV@613|Serratia	1236|Gammaproteobacteria	FG	HIT domain	hit	-	-	-	-	-	-	-	-	-	-	-	HIT
LZS3_k127_2084963_22	324057.Pjdr2_1069	3.469e-06	58.0	COG1238@1|root,COG1238@2|Bacteria,1V63I@1239|Firmicutes,4HHFZ@91061|Bacilli,26W23@186822|Paenibacillaceae	91061|Bacilli	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
LZS3_k127_2084963_24	1280001.BAOA01000258_gene5235	0.0004634	54.0	COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria,1T39R@1236|Gammaproteobacteria,1Y34S@135623|Vibrionales	135623|Vibrionales	UW	folic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2084963_25	1250006.JHZZ01000001_gene1109	0.0004714	52.0	COG1501@1|root,COG2273@1|root,COG1501@2|Bacteria,COG2273@2|Bacteria,4P7X5@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
LZS3_k127_2084963_26	1249975.JQLP01000003_gene136	0.0006215	51.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin_3,DUF285,TSP_3
LZS3_k127_2084963_10	246194.CHY_1057	6.265e-66	235.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,42JFW@68295|Thermoanaerobacterales	186801|Clostridia	M	RmlD substrate binding domain	-	-	4.1.1.35,5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274,ko:K08678	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R01384,R02984,R05176	RC00289,RC00508,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
LZS3_k127_2084963_12	314230.DSM3645_19723	1.033e-59	214.0	COG1215@1|root,COG1215@2|Bacteria,2J52E@203682|Planctomycetes	203682|Planctomycetes	M	involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
LZS3_k127_2084963_8	868131.MSWAN_1855	4.739e-70	268.0	COG1287@1|root,arCOG02044@2157|Archaea,2XU59@28890|Euryarchaeota,23NKH@183925|Methanobacteria	183925|Methanobacteria	M	PFAM Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18,2.4.99.21	ko:K07151,ko:K21306	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
LZS3_k127_2084963_19	717606.PaecuDRAFT_1287	7.992e-20	103.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,26R6M@186822|Paenibacillaceae	91061|Bacilli	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_2084963_3	990073.ATHU01000001_gene1056	1.448e-106	368.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2YND5@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	asparagine	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
LZS3_k127_2084963_7	523845.AQXV01000055_gene154	6.508e-77	271.0	COG0438@1|root,arCOG01415@2157|Archaea,2XUVW@28890|Euryarchaeota,23R82@183939|Methanococci	183939|Methanococci	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
LZS3_k127_2084963_0	95619.PM1_0228140	1.088e-122	402.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
LZS3_k127_2084963_9	1196322.A370_05544	2.5e-67	240.0	COG1089@1|root,COG1089@2|Bacteria,1UP3Y@1239|Firmicutes,25H66@186801|Clostridia,36V96@31979|Clostridiaceae	186801|Clostridia	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
LZS3_k127_2505125_11	289376.THEYE_A0218	9.604e-97	332.0	COG1379@1|root,COG1379@2|Bacteria	2|Bacteria	-	-	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
LZS3_k127_2505125_52	868131.MSWAN_2333	1.61e-05	54.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y1MD@28890|Euryarchaeota	28890|Euryarchaeota	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_4	1283300.ATXB01000001_gene771	2.571e-136	447.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1RNVK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrB	GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
LZS3_k127_2505125_32	237368.SCABRO_04002	6.345e-20	102.0	COG3343@1|root,COG4733@1|root,COG3343@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	DUF285,PA14,TSP_3,VCBS,fn3
LZS3_k127_2505125_7	635013.TherJR_2449	6.789e-110	366.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,260FH@186807|Peptococcaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
LZS3_k127_2505125_0	635013.TherJR_2450	1.449e-243	767.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,260NN@186807|Peptococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
LZS3_k127_2505125_20	1347392.CCEZ01000022_gene830	3.275e-30	124.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,36IQB@31979|Clostridiaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
LZS3_k127_2505125_54	926690.KE386573_gene3049	0.0001807	54.0	arCOG02540@1|root,arCOG02540@2157|Archaea	2157|Archaea	O	Belongs to the peptidase C1 family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_10	237368.SCABRO_00460	7.083e-102	338.0	COG3617@1|root,COG3617@2|Bacteria	2|Bacteria	K	BRO family, N-terminal domain	-	-	-	ko:K14623	-	-	-	-	ko00000,ko03400	-	-	-	Bro-N
LZS3_k127_2505125_37	456442.Mboo_0399	7.161e-14	76.0	arCOG05148@1|root,arCOG05148@2157|Archaea,2Y5UM@28890|Euryarchaeota,2NBC5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_38	456442.Mboo_0398	1.704e-13	74.0	arCOG05149@1|root,arCOG05149@2157|Archaea,2Y4ZG@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_51	756883.Halar_2532	6.98e-06	50.0	COG5378@1|root,arCOG02121@2157|Archaea	2157|Archaea	S	PFAM Nucleotide-binding protein, PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_2
LZS3_k127_2505125_50	1123399.AQVE01000023_gene456	4.706e-06	51.0	COG2002@1|root,COG2002@2|Bacteria,1N3BE@1224|Proteobacteria,1SF49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
LZS3_k127_2505125_26	103690.17134090	5.683e-25	110.0	COG1569@1|root,COG1569@2|Bacteria,1G7ZZ@1117|Cyanobacteria,1HSZM@1161|Nostocales	1117|Cyanobacteria	S	PIN domain	-	-	-	ko:K07063	-	-	-	-	ko00000	-	-	-	PIN_3
LZS3_k127_2505125_16	1094980.Mpsy_0399	1.09e-51	198.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,2N9A6@224756|Methanomicrobia	224756|Methanomicrobia	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
LZS3_k127_2505125_2	69014.TK1264	4.609e-210	670.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245CQ@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
LZS3_k127_2505125_22	871968.DESME_04750	1.561e-28	128.0	COG1232@1|root,COG1232@2|Bacteria	2|Bacteria	H	protoporphyrinogen oxidase activity	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
LZS3_k127_2505125_8	523850.TON_1634	1.745e-107	358.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2435F@183968|Thermococci	183968|Thermococci	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
LZS3_k127_2505125_17	868131.MSWAN_1950	1.149e-51	211.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
LZS3_k127_2505125_35	1297742.A176_06321	5.702e-18	93.0	COG0546@1|root,COG0546@2|Bacteria,1NZNU@1224|Proteobacteria,433UX@68525|delta/epsilon subdivisions,2X3K2@28221|Deltaproteobacteria,2YWDC@29|Myxococcales	28221|Deltaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAD
LZS3_k127_2505125_36	1121870.AUAA01000093_gene1124	1.446e-17	83.0	2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia	976|Bacteroidetes	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_48	457424.BFAG_04906	2.042e-06	53.0	2DSTI@1|root,33HD4@2|Bacteria,4PB58@976|Bacteroidetes,2FVZ6@200643|Bacteroidia,4ASJU@815|Bacteroidaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_46	411467.BACCAP_04470	3.625e-07	52.0	2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes	1239|Firmicutes	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_33	596152.DesU5LDRAFT_2681	6.731e-19	90.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_5	218851.Aquca_035_00152.1	4.145e-119	392.0	COG0162@1|root,KOG2144@2759|Eukaryota,37ICN@33090|Viridiplantae,3GE8R@35493|Streptophyta	35493|Streptophyta	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005488,GO:0005515,GO:0005524,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046983,GO:0071704,GO:0072545,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
LZS3_k127_2505125_44	1179778.PMM47T1_15426	7.413e-08	63.0	COG2267@1|root,COG2267@2|Bacteria,1MUFB@1224|Proteobacteria,1RYM9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
LZS3_k127_2505125_21	224325.AF_2106	6.277e-30	127.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,245S3@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24
LZS3_k127_2505125_12	1499967.BAYZ01000187_gene3876	5.737e-76	265.0	COG0697@1|root,COG0697@2|Bacteria,2NQTD@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	yoaV3	-	-	-	-	-	-	-	-	-	-	-	EamA
LZS3_k127_2505125_9	224325.AF_1299	7.742e-104	346.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
LZS3_k127_2505125_45	1384066.JAGT01000001_gene1661	1.42e-07	61.0	COG0584@1|root,COG0584@2|Bacteria,1UGF1@1239|Firmicutes,25E4R@186801|Clostridia,3WS66@541000|Ruminococcaceae	186801|Clostridia	C	Membrane domain of glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD,GPDPase_memb
LZS3_k127_2505125_25	2850.Phatr35818	2.607e-25	108.0	COG0350@1|root,2S8GR@2759|Eukaryota	2759|Eukaryota	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
LZS3_k127_2505125_27	55529.EKX44142	8.886e-25	111.0	2C37D@1|root,2S2T7@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_28	186497.PF1673	4.221e-24	108.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
LZS3_k127_2505125_1	589924.Ferp_1609	1.022e-220	722.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2462I@183980|Archaeoglobi	183980|Archaeoglobi	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
LZS3_k127_2505125_3	1476973.JMMB01000007_gene316	1.154e-142	463.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,25QEB@186804|Peptostreptococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
LZS3_k127_2505125_19	400668.Mmwyl1_0257	1.625e-36	145.0	2CCI4@1|root,30BPJ@2|Bacteria,1RE42@1224|Proteobacteria,1S47G@1236|Gammaproteobacteria,1XPD2@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_2505125_53	192952.MM_1474	9.487e-05	54.0	COG0535@1|root,arCOG00943@2157|Archaea,2Y2FM@28890|Euryarchaeota,2NAHZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
LZS3_k127_2505125_30	589865.DaAHT2_1130	2.741e-22	109.0	COG0535@1|root,COG0535@2|Bacteria,1R5RB@1224|Proteobacteria,42NU3@68525|delta/epsilon subdivisions,2WJ27@28221|Deltaproteobacteria,2MJDN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
LZS3_k127_2505125_34	1423321.AS29_08095	1.797e-18	94.0	COG1611@1|root,COG1611@2|Bacteria,1V2D7@1239|Firmicutes,4HF8E@91061|Bacilli,1ZMM0@1386|Bacillus	91061|Bacilli	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
LZS3_k127_2505125_6	293826.Amet_2171	1.275e-118	394.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,36FA9@31979|Clostridiaceae	186801|Clostridia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
LZS3_k127_2505125_29	990073.ATHU01000001_gene1302	1.133e-23	105.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2YPES@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Belongs to the thioredoxin family	trx2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
LZS3_k127_2505125_14	1162668.LFE_1068	1.95e-56	207.0	COG0682@1|root,COG0682@2|Bacteria,3J0G4@40117|Nitrospirae	40117|Nitrospirae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
LZS3_k127_2505125_13	391623.TERMP_01834	1.66e-62	221.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
LZS3_k127_2505125_40	1047013.AQSP01000046_gene1789	5.646e-09	64.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07061,ko:K07075	-	-	-	-	ko00000,ko02048	-	-	-	NTP_transf_2
LZS3_k127_2505125_24	671065.MetMK1DRAFT_00022330	1.675e-25	113.0	COG1675@1|root,arCOG04270@2157|Archaea,2XR34@28889|Crenarchaeota	28889|Crenarchaeota	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha,TF_Zn_Ribbon
LZS3_k127_2505125_18	386456.JQKN01000004_gene195	4.919e-39	155.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,23PJA@183925|Methanobacteria	183925|Methanobacteria	S	Phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
LZS3_k127_2505125_15	439235.Dalk_3397	2.563e-53	216.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
LZS3_k127_2505125_23	1343739.PAP_01470	8.117e-26	114.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,242JZ@183968|Thermococci	183968|Thermococci	S	Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins.	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
LZS3_k127_2505125_47	673860.AciM339_0306	7.169e-07	56.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,3F3BW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Pfam:DUF552	sepF	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
LZS3_k127_2505125_55	406124.ACPC01000018_gene2541	0.0003267	46.0	COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,4HB6D@91061|Bacilli,1ZQFX@1386|Bacillus	91061|Bacilli	GJM	Nucleotidyl transferase	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I
LZS3_k127_2614604_0	2850.Phatr45917	1.962e-137	441.0	COG3781@1|root,2QSQE@2759|Eukaryota,2XA7F@2836|Bacillariophyta	2836|Bacillariophyta	S	Bestrophin, RFP-TM, chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Bestrophin
LZS3_k127_2614604_1	159749.K0SEF6	1.505e-23	105.0	KOG3996@1|root,KOG3996@2759|Eukaryota,2XCZ1@2836|Bacillariophyta	2836|Bacillariophyta	CO	Links covalently the heme group to the apoprotein of cytochrome c	-	-	4.4.1.17	ko:K01764	ko00860,map00860	-	R02480	RC00727,RC02130	ko00000,ko00001,ko01000	-	-	-	Cyto_heme_lyase
LZS3_k127_3313913_28	1464048.JNZS01000002_gene589	2.062e-10	74.0	COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,SLH
LZS3_k127_3313913_46	272557.APE_0594a.1	0.0005261	46.0	COG3432@1|root,arCOG01055@2157|Archaea,2XREG@28889|Crenarchaeota	28889|Crenarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
LZS3_k127_3313913_19	1137271.AZUM01000010_gene1712	2.748e-20	98.0	COG1651@1|root,COG1651@2|Bacteria,2IGR9@201174|Actinobacteria,4E3BX@85010|Pseudonocardiales	201174|Actinobacteria	O	DSBA-like thioredoxin domain	dsbA	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
LZS3_k127_3313913_14	754027.HMPREF9554_01972	7.727e-33	132.0	COG4741@1|root,COG4741@2|Bacteria,2J8ES@203691|Spirochaetes	203691|Spirochaetes	F	COGs COG4741 secreted endonuclease distantly related to Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
LZS3_k127_3313913_6	647113.Metok_1389	2.246e-79	279.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,23Q03@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
LZS3_k127_3313913_3	1237149.C900_04719	1.333e-114	377.0	COG0451@1|root,COG0451@2|Bacteria,4NE3U@976|Bacteroidetes,47JUZ@768503|Cytophagia	976|Bacteroidetes	M	PFAM NAD dependent epimerase dehydratase family	ltd	-	-	-	-	-	-	-	-	-	-	-	Epimerase
LZS3_k127_3313913_8	247490.KSU1_C1464	4.397e-57	209.0	COG0053@1|root,COG0053@2|Bacteria,2IY05@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
LZS3_k127_3313913_44	487796.Flav2ADRAFT_0898	0.0002243	51.0	COG0527@1|root,COG0527@2|Bacteria,4NJDY@976|Bacteroidetes,1HYZX@117743|Flavobacteriia	976|Bacteroidetes	E	aspartate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3313913_9	351627.Csac_2267	4.225e-53	194.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,42ES7@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
LZS3_k127_3313913_11	243232.MJ_1364	5.097e-37	155.0	COG0585@1|root,arCOG04252@2157|Archaea,2XVPH@28890|Euryarchaeota,23Q00@183939|Methanococci	183939|Methanococci	J	tRNA pseudouridine synthase D	-	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
LZS3_k127_3313913_21	926550.CLDAP_07570	2.041e-17	94.0	COG0392@1|root,COG0392@2|Bacteria,2G96G@200795|Chloroflexi	200795|Chloroflexi	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
LZS3_k127_3313913_17	368407.Memar_2440	1.837e-27	123.0	COG0613@1|root,arCOG00302@2157|Archaea,2Y3KK@28890|Euryarchaeota	28890|Euryarchaeota	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
LZS3_k127_3313913_20	195522.BD01_1847	6.076e-19	93.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,243AW@183968|Thermococci	183968|Thermococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
LZS3_k127_3313913_18	484770.UFO1_2361	6.064e-25	111.0	COG1183@1|root,COG1183@2|Bacteria,1TR44@1239|Firmicutes,4H442@909932|Negativicutes	909932|Negativicutes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
LZS3_k127_3313913_16	419665.Maeo_0348	2.925e-30	128.0	COG0688@1|root,arCOG04470@2157|Archaea,2XX5J@28890|Euryarchaeota,23QV8@183939|Methanococci	183939|Methanococci	I	Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer)	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
LZS3_k127_3313913_2	243232.MJ_0019	4.451e-132	442.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,23QDW@183939|Methanococci	183939|Methanococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
LZS3_k127_3313913_0	647113.Metok_0524	5.845e-276	872.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
LZS3_k127_3313913_39	1121904.ARBP01000036_gene2088	3.869e-05	55.0	COG4099@1|root,COG4733@1|root,COG4099@2|Bacteria,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes	976|Bacteroidetes	O	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PA14,fn3
LZS3_k127_3313913_15	521098.Aaci_1974	2.358e-31	126.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,4H9NY@91061|Bacilli,2783P@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	yqfO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	NIF3
LZS3_k127_3313913_12	4896.SPCC830.10.1	6.956e-36	144.0	COG0127@1|root,KOG3222@2759|Eukaryota,38DZ3@33154|Opisthokonta,3P1W0@4751|Fungi,3QNUD@4890|Ascomycota,3ME1A@451866|Taphrinomycotina	4751|Fungi	F	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions	HAM1	GO:0003674,GO:0003824,GO:0004170,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008828,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036217,GO:0036218,GO:0036219,GO:0036220,GO:0036221,GO:0036222,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0047840,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.4.3	ko:K01519,ko:K18532	ko00230,ko00983,ko01100,ko01110,ko01130,ko03008,map00230,map00983,map01100,map01110,map01130,map03008	M00049	R00127,R00426,R00720,R01547,R01855,R02100,R02720,R03531,R08243	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	Ham1p_like
LZS3_k127_3313913_5	1042877.GQS_03195	1.716e-86	301.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2439K@183968|Thermococci	183968|Thermococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
LZS3_k127_3313913_25	186497.PF1987	3.813e-13	75.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2Y3ZJ@28890|Euryarchaeota,24450@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3313913_10	1123508.JH636439_gene1332	8.662e-39	156.0	COG1502@1|root,COG1502@2|Bacteria,2IZPW@203682|Planctomycetes	203682|Planctomycetes	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
LZS3_k127_3313913_38	1218086.BBNB01000008_gene153	1.648e-05	59.0	COG2373@1|root,COG2911@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
LZS3_k127_3313913_41	1184251.TCELL_1205	9.817e-05	57.0	COG0433@1|root,arCOG00282@2157|Archaea,2XQ27@28889|Crenarchaeota	28889|Crenarchaeota	L	SMART AAA ATPase	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
LZS3_k127_3313913_1	96561.Dole_0357	6.106e-196	618.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MI5G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
LZS3_k127_3313913_22	218493.SBG_3705	2.048e-17	100.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3ZJZS@590|Salmonella	1236|Gammaproteobacteria	Q	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,VCBS
LZS3_k127_3313913_34	1239962.C943_01342	1.447e-06	63.0	COG3055@1|root,COG3291@1|root,COG3866@1|root,COG4733@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,COG3866@2|Bacteria,COG4733@2|Bacteria,4NXBV@976|Bacteroidetes,47SGI@768503|Cytophagia	976|Bacteroidetes	M	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
LZS3_k127_3313913_43	1096546.WYO_5689	0.0001564	51.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,2TVMK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5,Rhodanese
LZS3_k127_3313913_45	1151292.QEW_3405	0.0004058	53.0	COG2247@1|root,COG2247@2|Bacteria,1V6RJ@1239|Firmicutes,24NWP@186801|Clostridia	186801|Clostridia	M	Putative cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2
LZS3_k127_3313913_49	429009.Adeg_0119	0.000738	50.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD,SprB
LZS3_k127_3313913_23	1122179.KB890414_gene1851	3.571e-17	96.0	COG1361@1|root,COG3209@1|root,COG4886@1|root,COG4935@1|root,COG1361@2|Bacteria,COG3209@2|Bacteria,COG4886@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,CHU_C,CUB,CW_binding_2,PKD,P_proprotein
LZS3_k127_3313913_40	68194.JNXR01000031_gene2784	5.113e-05	57.0	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Malectin,PA14
LZS3_k127_3313913_30	693661.Arcve_1359	4.89e-09	70.0	COG3291@1|root,COG3979@1|root,arCOG02499@1|root,arCOG02552@1|root,arCOG03439@1|root,arCOG02499@2157|Archaea,arCOG02552@2157|Archaea,arCOG03439@2157|Archaea,arCOG03504@2157|Archaea,arCOG07581@2157|Archaea,2XXWR@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
LZS3_k127_3313913_4	1151117.AJLF01000001_gene1311	1.432e-89	319.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
LZS3_k127_3313913_13	868131.MSWAN_2092	1.561e-33	139.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota	28890|Euryarchaeota	C	nitroreductase	-	-	1.13.11.79	ko:K04719	ko00740,ko01100,map00740,map01100	-	R09083	RC00435,RC02413	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
LZS3_k127_3313913_7	553973.CLOHYLEM_05952	1.95e-78	273.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,21YQP@1506553|Lachnoclostridium	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
LZS3_k127_3313913_26	1382359.JIAL01000001_gene2437	4.009e-12	78.0	COG0760@1|root,COG0760@2|Bacteria,3Y3BW@57723|Acidobacteria,2JIP1@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
LZS3_k127_3313913_48	935557.ATYB01000008_gene5407	0.0007267	52.0	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,2TWRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
LZS3_k127_3313913_36	1397284.AYMN01000158_gene3690	2.673e-06	62.0	COG5295@1|root,COG5295@2|Bacteria,1N338@1224|Proteobacteria,1RPXV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	UW	Autotransporter adhesin	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	ESPR,YadA_anchor,YadA_head,YadA_stalk
LZS3_k127_3313913_47	1034807.FBFL15_0915	0.0006537	54.0	2A2GV@1|root,30QU7@2|Bacteria,4NYES@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3313913_33	1033806.HTIA_p3067	1.324e-06	58.0	arCOG04041@1|root,arCOG07592@2157|Archaea,2Y8F4@28890|Euryarchaeota,241A5@183963|Halobacteria	183963|Halobacteria	S	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3313913_29	1379698.RBG1_1C00001G0282	1.74e-09	70.0	COG5276@1|root,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria	2|Bacteria	M	Hep Hag repeat protein	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Calx-beta,LVIVD
LZS3_k127_3313913_31	1229487.AMYW01000001_gene3873	8.13e-08	68.0	COG3209@1|root,COG4886@1|root,COG5184@1|root,COG3209@2|Bacteria,COG4886@2|Bacteria,COG5184@2|Bacteria,4NMJ3@976|Bacteroidetes,1I2GQ@117743|Flavobacteriia,2P052@237|Flavobacterium	976|Bacteroidetes	M	leucine- rich repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_4,Laminin_G_3,RCC1,SprB
LZS3_k127_3313913_27	247490.KSU1_C1544	9.563e-12	81.0	COG2755@1|root,COG5306@1|root,COG2755@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	exbB2	-	3.4.14.5	ko:K01278,ko:K03561,ko:K12287	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
LZS3_k127_3313913_42	938709.AUSH02000027_gene1961	0.0001333	57.0	COG3405@1|root,COG4886@1|root,COG3405@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CBM_15,CHU_C,DUF11,Flg_new,I-set,Laminin_G_3,fn3
LZS3_k127_3313913_24	1209072.ALBT01000031_gene1886	7.247e-17	98.0	COG2372@1|root,COG3209@1|root,COG2372@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	Big_5,DUF4082,SLH
LZS3_k127_3768590_2	1125725.HMPREF1325_1104	5.264e-50	188.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
LZS3_k127_3768590_4	439481.Aboo_0131	5.775e-24	118.0	COG1708@1|root,COG1895@1|root,arCOG01204@2157|Archaea,arCOG02123@2157|Archaea,2Y5D9@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_3768590_3	1220534.B655_1648	3.134e-44	167.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23PJV@183925|Methanobacteria	183925|Methanobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
LZS3_k127_3768590_6	1220534.B655_2061	1.13e-11	68.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,23P9S@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
LZS3_k127_3768590_7	649638.Trad_2465	1.091e-10	74.0	29X33@1|root,30IRP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_3768590_0	269797.Mbar_A2985	7.74e-73	259.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0668 Small-conductance mechanosensitive channel	mscS1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
LZS3_k127_3768590_1	1538644.KO02_14825	1.098e-51	199.0	COG1252@1|root,COG1252@2|Bacteria,4NE0H@976|Bacteroidetes,1IQYG@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
LZS3_k127_3768590_5	339671.Asuc_1310	2.99e-21	96.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,1SAJR@1236|Gammaproteobacteria,1Y8WC@135625|Pasteurellales	135625|Pasteurellales	S	membrane	Z012_09115	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
LZS3_k127_4870627_1	634497.HAH_0385	1.536e-07	53.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,23SS5@183963|Halobacteria	183963|Halobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
LZS3_k127_4870627_0	868131.MSWAN_0771	7.128e-286	914.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,23NVS@183925|Methanobacteria	183925|Methanobacteria	L	helicase	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
LZS3_k127_5173842_28	194867.ALBQ01000021_gene1977	1.643e-18	85.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2K0E3@204457|Sphingomonadales	204457|Sphingomonadales	O	ABC-type transport system involved in Fe-S cluster assembly, ATPase component	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
LZS3_k127_5173842_49	1122138.AQUZ01000074_gene7344	5.699e-06	56.0	COG1708@1|root,COG1708@2|Bacteria,2IJS1@201174|Actinobacteria,4DUDM@85009|Propionibacteriales	201174|Actinobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_5173842_46	647113.Metok_1160	3.801e-08	58.0	arCOG05148@1|root,arCOG05148@2157|Archaea,2Y5I4@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5173842_45	368407.Memar_1638	1.066e-08	61.0	arCOG05149@1|root,arCOG05149@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5173842_20	1242864.D187_003027	9.917e-30	123.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria	1224|Proteobacteria	S	Nuclear protein SET	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
LZS3_k127_5173842_50	113355.CM001775_gene3551	0.0002215	51.0	COG1708@1|root,COG1708@2|Bacteria,1G7S7@1117|Cyanobacteria	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_5173842_6	31033.ENSTRUP00000033087	1.625e-86	298.0	COG1899@1|root,KOG2924@2759|Eukaryota,38CMK@33154|Opisthokonta,3B9RP@33208|Metazoa,3CZJ5@33213|Bilateria,488MM@7711|Chordata,4967Y@7742|Vertebrata,49VA6@7898|Actinopterygii	33208|Metazoa	O	Deoxyhypusine synthase	DHPS	GO:0002682,GO:0002684,GO:0002694,GO:0002696,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006464,GO:0006518,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008284,GO:0008612,GO:0009056,GO:0009058,GO:0009059,GO:0009308,GO:0009310,GO:0009987,GO:0010467,GO:0016043,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0022407,GO:0022409,GO:0022607,GO:0030155,GO:0032944,GO:0032946,GO:0033500,GO:0034038,GO:0034641,GO:0034645,GO:0036211,GO:0042102,GO:0042127,GO:0042129,GO:0042402,GO:0042592,GO:0042593,GO:0042802,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045785,GO:0046203,GO:0048518,GO:0048522,GO:0048878,GO:0050670,GO:0050671,GO:0050789,GO:0050794,GO:0050863,GO:0050865,GO:0050867,GO:0050870,GO:0051249,GO:0051251,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051604,GO:0065003,GO:0065007,GO:0065008,GO:0070663,GO:0070665,GO:0071704,GO:0071840,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1903037,GO:1903039	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
LZS3_k127_5173842_29	1184251.TCELL_0534	2.415e-18	86.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
LZS3_k127_5173842_0	555079.Toce_0772	6.269e-288	911.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42ER6@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
LZS3_k127_5173842_10	1192034.CAP_8119	8.839e-50	195.0	COG5184@1|root,COG5184@2|Bacteria,1QUHA@1224|Proteobacteria,42VF6@68525|delta/epsilon subdivisions,2WR7F@28221|Deltaproteobacteria,2YV9Z@29|Myxococcales	28221|Deltaproteobacteria	DZ	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3
LZS3_k127_5173842_47	523845.AQXV01000047_gene776	8.862e-08	60.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX3W@28890|Euryarchaeota,23QY6@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
LZS3_k127_5173842_30	321327.CYA_2617	5.009e-17	87.0	COG4243@1|root,COG4243@2|Bacteria,1FZWT@1117|Cyanobacteria,1GYP5@1129|Synechococcus	1117|Cyanobacteria	CO	Vitamin K epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
LZS3_k127_5173842_22	1459636.NTE_02673	5.133e-28	121.0	arCOG01449@1|root,arCOG01449@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5173842_18	926569.ANT_28370	3.427e-34	142.0	COG1651@1|root,COG1651@2|Bacteria,2G769@200795|Chloroflexi	200795|Chloroflexi	O	PFAM DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
LZS3_k127_5173842_24	402880.MmarC5_0759	1.262e-25	110.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,23R14@183939|Methanococci	183939|Methanococci	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
LZS3_k127_5173842_14	523850.TON_1694	1.42e-37	158.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
LZS3_k127_5173842_13	604354.TSIB_1020	2.162e-41	161.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,2434C@183968|Thermococci	183968|Thermococci	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
LZS3_k127_5173842_33	1121904.ARBP01000083_gene4096	1.358e-13	85.0	COG3386@1|root,COG4733@1|root,COG5184@1|root,COG3386@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,4NK33@976|Bacteroidetes	976|Bacteroidetes	G	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
LZS3_k127_5173842_41	3067.XP_002956828.1	2.141e-09	71.0	COG4870@1|root,KOG1543@2759|Eukaryota	2759|Eukaryota	O	cysteine-type peptidase activity	-	-	3.4.18.1,3.4.22.15,3.4.22.38	ko:K01365,ko:K01371,ko:K08568,ko:K16292	ko04140,ko04142,ko04145,ko04210,ko04380,ko04612,ko04620,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04380,map04612,map04620,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Granulin,Inhibitor_I29,Peptidase_C1
LZS3_k127_5173842_26	868131.MSWAN_0291	1.231e-24	116.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
LZS3_k127_5173842_32	545693.BMQ_3513	1.133e-13	85.0	COG0574@1|root,COG0574@2|Bacteria,1UYA0@1239|Firmicutes,4HD4S@91061|Bacilli,1ZAW5@1386|Bacillus	91061|Bacilli	GT	phosphoenolpyruvate synthase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
LZS3_k127_5173842_9	351160.RCIX768	5.404e-75	260.0	COG1830@1|root,arCOG04044@2157|Archaea,2XSY2@28890|Euryarchaeota,2NB1A@224756|Methanomicrobia	224756|Methanomicrobia	G	DeoC/LacD family aldolase	-	-	2.2.1.11,4.1.2.13	ko:K11645,ko:K16305	ko00010,ko00030,ko00051,ko00400,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568,R10049,R10050	RC00438,RC00439,RC00603,RC00604,RC02301,RC03034	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
LZS3_k127_5173842_7	745411.B3C1_12739	8.076e-81	281.0	COG0524@1|root,COG0524@2|Bacteria,1QTMT@1224|Proteobacteria,1S1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
LZS3_k127_5173842_34	673860.AciM339_0310	2.146e-12	78.0	COG1630@1|root,arCOG00367@2157|Archaea,2Y1H6@28890|Euryarchaeota	28890|Euryarchaeota	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
LZS3_k127_5173842_4	237368.SCABRO_03725	3.158e-153	491.0	COG1697@1|root,COG1697@2|Bacteria,2J34C@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
LZS3_k127_5173842_2	237368.SCABRO_03724	3.626e-176	570.0	COG1389@1|root,COG1389@2|Bacteria,2J2A8@203682|Planctomycetes	203682|Planctomycetes	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
LZS3_k127_5173842_12	579137.Metvu_0184	2.759e-48	178.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
LZS3_k127_5173842_11	386456.JQKN01000001_gene2164	2.589e-48	182.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,23P1N@183925|Methanobacteria	183925|Methanobacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
LZS3_k127_5173842_5	1343739.PAP_02330	5.889e-112	376.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
LZS3_k127_5173842_35	1094980.Mpsy_1745	9.969e-12	71.0	COG0294@1|root,arCOG01978@2157|Archaea	2157|Archaea	H	dihydropteroate synthase	-	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
LZS3_k127_5173842_27	756883.Halar_0736	7.66e-21	100.0	COG1736@1|root,arCOG04112@2157|Archaea	2157|Archaea	J	Diphthamide biosynthesis	dph2	GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016765,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0048037,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0051536,GO:0051539,GO:0051540,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
LZS3_k127_5173842_42	558173.CDOO_07340	2.409e-09	68.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,22JWT@1653|Corynebacteriaceae	201174|Actinobacteria	L	RecB family exonuclease	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
LZS3_k127_5173842_23	420247.Msm_1091	1.063e-26	121.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,23NJZ@183925|Methanobacteria	183925|Methanobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
LZS3_k127_5173842_8	796620.VIBC2010_02331	2.265e-79	278.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1RMCP@1236|Gammaproteobacteria,1Y0HD@135623|Vibrionales	135623|Vibrionales	F	Dihydroorotate dehydrogenase	-	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
LZS3_k127_5173842_17	1047013.AQSP01000128_gene441	1.561e-34	145.0	COG0628@1|root,COG0628@2|Bacteria,2NPIB@2323|unclassified Bacteria	2|Bacteria	S	AI-2E family transporter	-	-	-	ko:K11744	-	-	-	-	ko00000	-	-	-	AI-2E_transport
LZS3_k127_5173842_16	1996.JOFO01000055_gene1168	2.618e-35	145.0	COG2856@1|root,COG2856@2|Bacteria,2I26R@201174|Actinobacteria,4EQIR@85012|Streptosporangiales	201174|Actinobacteria	E	Putative metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4344
LZS3_k127_5173842_25	351160.LRC485	8.071e-25	110.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,2NA1Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
LZS3_k127_5173842_3	868131.MSWAN_1826	7.452e-162	524.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,23NQ3@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
LZS3_k127_5173842_48	1123058.KB894262_gene1438	6.284e-07	61.0	COG1522@1|root,COG1522@2|Bacteria,4NHG9@976|Bacteroidetes,1HXEQ@117743|Flavobacteriia	976|Bacteroidetes	K	transcriptional regulator	asnC	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
LZS3_k127_5173842_21	224325.AF_0999	5.001e-29	124.0	COG2512@1|root,arCOG00376@2157|Archaea,2Y8HT@28890|Euryarchaeota	28890|Euryarchaeota	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5173842_39	521095.Apar_1168	3.178e-10	65.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	arsR	-	-	ko:K03892,ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
LZS3_k127_5173842_19	243233.MCA2981	6.003e-34	142.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
LZS3_k127_5173842_40	1094980.Mpsy_1262	1.678e-09	70.0	arCOG02083@1|root,arCOG02083@2157|Archaea,2Y2FI@28890|Euryarchaeota,2NA9F@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5173842_1	697281.Mahau_1243	1.336e-238	761.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,42EQF@68295|Thermoanaerobacterales	186801|Clostridia	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
LZS3_k127_5173842_15	886379.AEWI01000022_gene192	6.62e-37	143.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,2FYEV@200643|Bacteroidia,3XKTU@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
LZS3_k127_5173842_43	714961.BFZC1_02927	3.6e-09	62.0	COG4633@1|root,COG4633@2|Bacteria,1VKDS@1239|Firmicutes,4HXFE@91061|Bacilli	91061|Bacilli	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
LZS3_k127_5173842_37	1168289.AJKI01000001_gene3682	1.486e-11	68.0	2EMYX@1|root,33FM2@2|Bacteria,4NY90@976|Bacteroidetes,2FZJV@200643|Bacteroidia,3XM0C@558415|Marinilabiliaceae	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5173842_31	946362.XP_004998342.1	2.469e-15	90.0	COG1053@1|root,COG1304@1|root,COG5274@1|root,KOG0537@2759|Eukaryota,KOG0538@2759|Eukaryota,KOG2404@2759|Eukaryota,38BCT@33154|Opisthokonta	33154|Opisthokonta	C	Hydroxyacid oxidase	-	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	Cyt-b5,FMN_dh
LZS3_k127_5173842_36	27289.XP_003670027.1	1.02e-11	78.0	COG1304@1|root,COG5274@1|root,KOG0537@2759|Eukaryota,KOG0538@2759|Eukaryota,38BCT@33154|Opisthokonta,3NTYS@4751|Fungi,3QMI4@4890|Ascomycota,3RSAQ@4891|Saccharomycetes,3RZ2K@4893|Saccharomycetaceae	4751|Fungi	C	to Saccharomyces cerevisiae CYB2 (YML054C)	CYB2	GO:0003674,GO:0003824,GO:0004457,GO:0004460,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016898,GO:0019752,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0070013,GO:0071704,GO:1901615	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	Cyt-b5,FMN_dh
LZS3_k127_5173842_44	309803.CTN_1202	9.908e-09	63.0	COG0500@1|root,COG2226@2|Bacteria,2GD3D@200918|Thermotogae	200918|Thermotogae	H	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
LZS3_k127_5836029_0	1343739.PAP_04700	2.869e-175	567.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,243N1@183968|Thermococci	183968|Thermococci	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
LZS3_k127_5836029_11	523850.TON_0715	2.994e-10	67.0	COG3270@1|root,arCOG02285@2157|Archaea,2XZD7@28890|Euryarchaeota,24491@183968|Thermococci	183968|Thermococci	J	RNA-binding PUA-like domain of methyltransferase RsmF	-	-	-	-	-	-	-	-	-	-	-	-	Methyltranf_PUA
LZS3_k127_5836029_7	644281.MFS40622_0621	3.833e-33	134.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,23QZV@183939|Methanococci	183939|Methanococci	J	PFAM PUA domain containing protein	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
LZS3_k127_5836029_3	716544.wcw_0762	2.933e-44	173.0	COG0837@1|root,COG0837@2|Bacteria,2JH4J@204428|Chlamydiae	204428|Chlamydiae	H	Glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
LZS3_k127_5836029_1	304371.MCP_0922	2.223e-105	374.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
LZS3_k127_5836029_15	1541065.JRFE01000054_gene6427	4.721e-05	48.0	COG2336@1|root,COG2336@2|Bacteria,1G9A5@1117|Cyanobacteria,3VKT7@52604|Pleurocapsales	1117|Cyanobacteria	T	Antidote-toxin recognition MazE, bacterial antitoxin	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
LZS3_k127_5836029_14	694429.Pyrfu_1859	4.024e-05	51.0	COG1848@1|root,arCOG02221@2157|Archaea,2XSEY@28889|Crenarchaeota	28889|Crenarchaeota	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS3_k127_5836029_4	1094980.Mpsy_0422	4.444e-40	162.0	COG0034@1|root,COG0367@1|root,COG2102@1|root,arCOG00035@2157|Archaea,arCOG00071@2157|Archaea,arCOG00093@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
LZS3_k127_5836029_2	399550.Smar_0809	5.949e-45	170.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
LZS3_k127_5836029_5	877455.Metbo_0714	1.294e-36	158.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
LZS3_k127_5836029_12	552811.Dehly_0805	6.915e-09	62.0	COG1403@1|root,COG1403@2|Bacteria,2GB06@200795|Chloroflexi,34DP8@301297|Dehalococcoidia	301297|Dehalococcoidia	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5836029_6	525904.Tter_0423	6.357e-35	145.0	COG0616@1|root,COG0616@2|Bacteria,2NPIE@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
LZS3_k127_5836029_8	243232.MJ_0445	2.342e-31	126.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
LZS3_k127_5836029_13	1220534.B655_2291	4.299e-06	53.0	arCOG01210@1|root,arCOG01210@2157|Archaea,2Y52Q@28890|Euryarchaeota,23PUD@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5836029_9	429009.Adeg_1605	9.631e-23	104.0	COG0597@1|root,COG0597@2|Bacteria,1VB1J@1239|Firmicutes,24PQ2@186801|Clostridia	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
LZS3_k127_5836029_10	1121870.AUAA01000007_gene215	4.892e-16	80.0	COG4912@1|root,COG4912@2|Bacteria,4NKBS@976|Bacteroidetes,1I0QG@117743|Flavobacteriia,3HHVJ@358033|Chryseobacterium	976|Bacteroidetes	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
LZS3_k127_5987372_12	673860.AciM339_1505	7.072e-33	143.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,3F2HN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	MCM OB domain	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB
LZS3_k127_5987372_13	926550.CLDAP_34290	1.664e-29	132.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Big_3_2,Cadherin-like,Calx-beta,DUF11,DUF4347,DUF4430,DUF915,FTP,HYR,I-set,PQQ_2,PT-HINT,Peptidase_M36,Pro-kuma_activ,RHS_repeat,VCBS
LZS3_k127_5987372_9	439481.Aboo_1545	1.008e-38	155.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
LZS3_k127_5987372_15	877455.Metbo_2075	1.944e-19	96.0	COG0560@1|root,COG1340@1|root,arCOG01158@2157|Archaea,arCOG01159@2157|Archaea,2XT0C@28890|Euryarchaeota,23NM8@183925|Methanobacteria	183925|Methanobacteria	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD,Hydrolase
LZS3_k127_5987372_14	1123388.AQWU01000060_gene896	6.189e-29	124.0	COG2095@1|root,COG2095@2|Bacteria,1WJXY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	U	UPF0056 membrane protein	marC	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
LZS3_k127_5987372_4	1356854.N007_11825	6.734e-80	279.0	COG3387@1|root,COG3387@2|Bacteria,1V0CI@1239|Firmicutes,4HCZU@91061|Bacilli	91061|Bacilli	G	Glycosyl hydrolases family 15	-	-	-	ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_15
LZS3_k127_5987372_21	1123389.ATXJ01000001_gene685	3.378e-05	55.0	COG2267@1|root,COG2267@2|Bacteria,1WJIG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Alpha beta hydrolase	-	-	3.1.1.24,4.1.1.44	ko:K01055,ko:K14727	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991,R03470	RC00825,RC00938	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,CMD
LZS3_k127_5987372_0	439481.Aboo_0751	1.366e-137	454.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,3F34M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
LZS3_k127_5987372_6	192952.MM_0373	3.352e-61	223.0	COG1721@1|root,arCOG02745@2157|Archaea,2XVGA@28890|Euryarchaeota,2NAC9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
LZS3_k127_5987372_1	192952.MM_0372	1.261e-119	391.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,2NA7N@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
LZS3_k127_5987372_19	1324957.K933_05508	2.579e-06	58.0	arCOG06258@1|root,arCOG06258@2157|Archaea,2XXI1@28890|Euryarchaeota,23VAC@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5987372_3	1227487.C474_20876	6.348e-100	357.0	arCOG02907@1|root,arCOG02907@2157|Archaea,2XVFW@28890|Euryarchaeota,23TI1@183963|Halobacteria	183963|Halobacteria	S	Von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
LZS3_k127_5987372_5	469382.Hbor_19710	2.36e-78	284.0	arCOG02905@1|root,arCOG02905@2157|Archaea,2XU82@28890|Euryarchaeota,23STF@183963|Halobacteria	183963|Halobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
LZS3_k127_5987372_17	679926.Mpet_0689	3.565e-19	94.0	COG1895@1|root,arCOG02123@2157|Archaea	2157|Archaea	S	protein related to C-terminal domain of eukaryotic chaperone, SACSIN	-	-	-	ko:K09132	-	-	-	-	ko00000	-	-	-	HEPN
LZS3_k127_5987372_23	592026.GCWU0000282_000157	0.0003034	50.0	COG1669@1|root,COG1669@2|Bacteria,1V5FK@1239|Firmicutes,24IJK@186801|Clostridia	186801|Clostridia	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,NTP_transf_2
LZS3_k127_5987372_11	204536.SULAZ_0367	5.686e-34	145.0	COG0166@1|root,COG0166@2|Bacteria,2G3Y6@200783|Aquificae	200783|Aquificae	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
LZS3_k127_5987372_18	1382359.JIAL01000001_gene123	7.542e-13	78.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria,2JHKB@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_5987372_16	1168065.DOK_06627	2.351e-19	98.0	2EG7N@1|root,339ZH@2|Bacteria,1NJ6P@1224|Proteobacteria,1SI7V@1236|Gammaproteobacteria,1J77K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Kazal_1
LZS3_k127_5987372_2	523850.TON_0507	1.789e-103	350.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
LZS3_k127_5987372_10	593117.TGAM_0464	3.196e-38	153.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,242JP@183968|Thermococci	183968|Thermococci	J	C D box methylation guide ribonucleoprotein complex aNOP56 subunit	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
LZS3_k127_5987372_7	243232.MJ_0697	6.032e-56	206.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,23QPI@183939|Methanococci	183939|Methanococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
LZS3_k127_5987372_8	877455.Metbo_1208	2.856e-51	190.0	COG0476@1|root,arCOG09483@1|root,arCOG01676@2157|Archaea,arCOG09483@2157|Archaea,2XTYV@28890|Euryarchaeota	28890|Euryarchaeota	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF
LZS3_k127_5987372_24	751944.HALDL1_13120	0.0009272	47.0	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,23TH8@183963|Halobacteria	183963|Halobacteria	C	COG0517 FOG CBS domain	cbs1	-	-	-	-	-	-	-	-	-	-	-	CBS
LZS3_k127_5987372_22	1121106.JQKB01000172_gene834	0.0001656	54.0	COG2133@1|root,COG5276@1|root,COG2133@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
LZS3_k127_5987372_20	1296415.JACC01000007_gene2373	3.25e-06	60.0	COG3209@1|root,COG3420@1|root,COG3209@2|Bacteria,COG3420@2|Bacteria,4NE5D@976|Bacteroidetes,1HYTK@117743|Flavobacteriia,2YHFX@290174|Aquimarina	976|Bacteroidetes	M	RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE
LZS3_k127_6319363_5	926550.CLDAP_17040	9.113e-38	167.0	COG5276@1|root,COG5276@2|Bacteria,2G8F2@200795|Chloroflexi	200795|Chloroflexi	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
LZS3_k127_6319363_12	404380.Gbem_2063	1.064e-08	71.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
LZS3_k127_6319363_9	83406.HDN1F_21550	3.717e-17	99.0	COG5276@1|root,COG5276@2|Bacteria,1R46A@1224|Proteobacteria,1RY7V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,LVIVD
LZS3_k127_6319363_14	1415775.U729_3154	9.39e-06	58.0	COG1467@1|root,COG1467@2|Bacteria,1VHYM@1239|Firmicutes	1239|Firmicutes	L	DNA primase activity	-	-	-	-	-	-	-	-	-	-	-	-	PriCT_1
LZS3_k127_6319363_2	574087.Acear_0714	1.613e-90	319.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,3WAE7@53433|Halanaerobiales	186801|Clostridia	S	pfam abc1	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
LZS3_k127_6319363_3	304371.MCP_2364	1.354e-62	229.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
LZS3_k127_6319363_13	1158338.JNLJ01000005_gene1773	1.394e-08	60.0	COG1658@1|root,COG1658@2|Bacteria,2G496@200783|Aquificae	200783|Aquificae	L	TOPRIM	-	-	-	-	-	-	-	-	-	-	-	-	Toprim,Toprim_2,Toprim_4
LZS3_k127_6319363_15	2903.EOD22028	9.621e-05	51.0	COG0484@1|root,KOG0713@2759|Eukaryota	2759|Eukaryota	O	protein folding	-	-	-	ko:K18412	-	-	-	-	ko00000,ko03019,ko03036	-	-	-	DnaJ
LZS3_k127_6319363_8	1249480.B649_04745	1.958e-24	116.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2YMHR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
LZS3_k127_6319363_4	1192034.CAP_6577	2.686e-48	196.0	COG2133@1|root,COG4935@1|root,COG2133@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Amidase_2,DUF11,Glyco_hydro_11,He_PIG,Malectin,PA14,P_proprotein
LZS3_k127_6319363_16	660470.Theba_2153	0.0005366	53.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF285,Flg_new,He_PIG,LVIVD,PKD,RHS_repeat
LZS3_k127_6319363_0	272844.PAB0190	9.886e-182	594.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
LZS3_k127_6319363_11	1463885.KL578385_gene9168	4.826e-10	70.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria	201174|Actinobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
LZS3_k127_6319363_10	593750.Metfor_2881	1.278e-10	65.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_6319363_7	593750.Metfor_1488	2.462e-30	128.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
LZS3_k127_6319363_6	456320.Mvol_1366	4.809e-33	132.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23QTK@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
LZS3_k127_6319363_1	751944.HALDL1_16390	1.466e-104	359.0	COG1372@1|root,COG1933@1|root,arCOG03145@2157|Archaea,arCOG03147@2157|Archaea,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23SG3@183963|Halobacteria	183963|Halobacteria	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
LZS3_k127_695686_16	324925.Ppha_0959	3.134e-19	93.0	2E747@1|root,331NN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_695686_1	713586.KB900536_gene247	1.353e-133	441.0	COG1468@1|root,COG1468@2|Bacteria,1QW0M@1224|Proteobacteria,1RS6B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
LZS3_k127_695686_13	195522.BD01_0631	1.546e-29	126.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,243KR@183968|Thermococci	183968|Thermococci	S	Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
LZS3_k127_695686_10	1035839.AFNK01000037_gene1286	1.145e-42	173.0	COG1222@1|root,COG1222@2|Bacteria,1R16G@1224|Proteobacteria,1T597@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	ATPase (AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA
LZS3_k127_695686_9	406327.Mevan_0084	2.945e-45	171.0	COG0640@1|root,arCOG01446@2157|Archaea,2XWN0@28890|Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM CRISPR locus-related DNA-binding	-	-	-	ko:K07725	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	Cas_APE2256,HTH_24,HTH_5
LZS3_k127_695686_11	304371.MCP_1619	5.581e-41	154.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ89@28890|Euryarchaeota	28890|Euryarchaeota	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like,tRNA_edit
LZS3_k127_695686_23	679926.Mpet_0689	7.152e-08	59.0	COG1895@1|root,arCOG02123@2157|Archaea	2157|Archaea	S	protein related to C-terminal domain of eukaryotic chaperone, SACSIN	-	-	-	ko:K09132	-	-	-	-	ko00000	-	-	-	HEPN
LZS3_k127_695686_33	156889.Mmc1_1075	0.0001838	52.0	COG1708@1|root,COG1708@2|Bacteria,1QWDG@1224|Proteobacteria	1224|Proteobacteria	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_695686_30	1094980.Mpsy_0722	1.736e-05	49.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y78I@28890|Euryarchaeota,2NB31@224756|Methanomicrobia	224756|Methanomicrobia	K	addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_695686_18	192952.MM_2550	6.527e-12	69.0	arCOG05071@1|root,arCOG05071@2157|Archaea,2Y0VX@28890|Euryarchaeota,2NBB9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2683)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2683
LZS3_k127_695686_12	749222.Nitsa_0976	2.675e-40	156.0	296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,42RDU@68525|delta/epsilon subdivisions,2YQ0Z@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_695686_25	857087.Metme_3741	1.133e-07	63.0	COG2202@1|root,COG2208@1|root,COG5000@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,COG5000@2|Bacteria,1RGZF@1224|Proteobacteria,1S6GG@1236|Gammaproteobacteria,1XDM4@135618|Methylococcales	135618|Methylococcales	KT	PFAM Stage II sporulation protein E (SpoIIE)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_9,SpoIIE
LZS3_k127_695686_5	1451261.AS96_06995	2.923e-56	205.0	COG3752@1|root,COG3752@2|Bacteria,2GNX1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
LZS3_k127_695686_7	1047013.AQSP01000120_gene965	4.351e-49	181.0	COG3476@1|root,COG3476@2|Bacteria,2NQ7D@2323|unclassified Bacteria	2|Bacteria	T	TspO/MBR family	tspO	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
LZS3_k127_695686_24	1157640.AQWO01000026_gene6061	8.707e-08	60.0	COG3468@1|root,COG3468@2|Bacteria,2I7QT@201174|Actinobacteria	201174|Actinobacteria	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_695686_3	1232410.KI421413_gene633	1.072e-69	239.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,42QWQ@68525|delta/epsilon subdivisions,2WMRI@28221|Deltaproteobacteria,43T93@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_695686_2	945543.VIBR0546_17143	1.254e-116	392.0	COG1262@1|root,COG1262@2|Bacteria,1R6GS@1224|Proteobacteria,1S5ET@1236|Gammaproteobacteria,1XU1P@135623|Vibrionales	135623|Vibrionales	C	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,DUF1566,EF-hand_5
LZS3_k127_695686_28	1123226.KB899278_gene728	1.672e-06	62.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,26TPD@186822|Paenibacillaceae	91061|Bacilli	M	lytic transglycosylase	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
LZS3_k127_695686_22	1274374.CBLK010000003_gene3264	6.103e-08	66.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4HGM6@91061|Bacilli,26ST2@186822|Paenibacillaceae	91061|Bacilli	M	Membrane proteins related to metalloendopeptidases	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
LZS3_k127_695686_20	448385.sce1039	5.729e-11	77.0	COG4935@1|root,COG4935@2|Bacteria,1QZ17@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein
LZS3_k127_695686_8	415426.Hbut_1421	9.31e-46	176.0	COG1355@1|root,arCOG01728@2157|Archaea,2XPQS@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
LZS3_k127_695686_19	1469613.JT55_12095	1.976e-11	74.0	COG3647@1|root,COG3647@2|Bacteria,1RGJN@1224|Proteobacteria,2U80P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_695686_29	1192034.CAP_1012	1.723e-05	59.0	COG4719@1|root,COG4870@1|root,COG4719@2|Bacteria,COG4870@2|Bacteria,1R0BA@1224|Proteobacteria,42VBW@68525|delta/epsilon subdivisions,2X811@28221|Deltaproteobacteria,2Z3J2@29|Myxococcales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
LZS3_k127_695686_4	1365176.N186_06180	2.025e-56	207.0	COG0037@1|root,arCOG00042@2157|Archaea,2XQ4Q@28889|Crenarchaeota	28889|Crenarchaeota	D	PFAM PP-loop domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
LZS3_k127_695686_17	1192034.CAP_3547	2.159e-13	85.0	COG3210@1|root,COG4786@1|root,COG5184@1|root,COG3210@2|Bacteria,COG4786@2|Bacteria,COG5184@2|Bacteria,1P1C6@1224|Proteobacteria,4310A@68525|delta/epsilon subdivisions,2WWWF@28221|Deltaproteobacteria,2Z029@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE
LZS3_k127_695686_32	639282.DEFDS_0603	2.848e-05	49.0	COG2104@1|root,COG2104@2|Bacteria,2GG4W@200930|Deferribacteres	200930|Deferribacteres	H	ThiS family	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
LZS3_k127_695686_6	1236689.MMALV_07170	1.721e-50	185.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,3F2KX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
LZS3_k127_695686_27	1158165.KB898874_gene1929	3.276e-07	59.0	COG1848@1|root,COG1848@2|Bacteria,1RFD9@1224|Proteobacteria	1224|Proteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
LZS3_k127_695686_0	358396.C445_06588	1.349e-149	513.0	COG1241@1|root,COG1372@1|root,arCOG03154@1|root,arCOG00439@2157|Archaea,arCOG03154@2157|Archaea,arCOG03158@2157|Archaea,2XT5D@28890|Euryarchaeota,23SII@183963|Halobacteria	183963|Halobacteria	L	ATPase involved in replication control, Cdc46 Mcm family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB
LZS3_k127_695686_26	644281.MFS40622_0598	1.167e-07	61.0	arCOG02261@1|root,arCOG02261@2157|Archaea,2XWQZ@28890|Euryarchaeota,23QUF@183939|Methanococci	183939|Methanococci	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
LZS3_k127_695686_34	1042877.GQS_02670	0.0004987	51.0	COG1300@1|root,arCOG01994@2157|Archaea,2XTS9@28890|Euryarchaeota,245H0@183968|Thermococci	183968|Thermococci	S	Stage II sporulation protein M	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
LZS3_k127_695686_21	767817.Desgi_1441	1.439e-08	64.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24BFV@186801|Clostridia,263RU@186807|Peptococcaceae	186801|Clostridia	C	PFAM Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
LZS3_k127_695686_14	1121472.AQWN01000001_gene85	2.075e-25	119.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,260J4@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
LZS3_k127_695686_31	1280946.HY29_04155	2.531e-05	53.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria	1224|Proteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
LZS3_k127_695686_15	926690.KE386573_gene2140	2.513e-19	98.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7G0@28890|Euryarchaeota,23Z51@183963|Halobacteria	183963|Halobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
LZS3_k127_7092881_2	386456.JQKN01000002_gene2857	5.602e-78	277.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,23NU4@183925|Methanobacteria	183925|Methanobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
LZS3_k127_7092881_8	246969.TAM4_1531	7.58e-34	138.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,243II@183968|Thermococci	183968|Thermococci	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
LZS3_k127_7092881_11	456442.Mboo_2184	1.175e-10	72.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota	28890|Euryarchaeota	L	chromosome segregation and condensation protein ScpA	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
LZS3_k127_7092881_13	1042877.GQS_07285	1.351e-07	63.0	COG1361@1|root,arCOG02079@2157|Archaea,2XZCT@28890|Euryarchaeota,242X1@183968|Thermococci	183968|Thermococci	M	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7092881_4	323259.Mhun_1426	1.422e-59	222.0	COG0577@1|root,arCOG02315@2157|Archaea,2XYJU@28890|Euryarchaeota,2N9SS@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
LZS3_k127_7092881_3	192952.MM_2665	8.793e-77	265.0	COG1136@1|root,arCOG00922@2157|Archaea,2XWHK@28890|Euryarchaeota,2N9GX@224756|Methanomicrobia	224756|Methanomicrobia	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
LZS3_k127_7092881_12	1227457.C451_04141	1.091e-09	67.0	COG3413@1|root,arCOG02271@2157|Archaea,2XU8X@28890|Euryarchaeota,23THS@183963|Halobacteria	183963|Halobacteria	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,HTH_10
LZS3_k127_7092881_9	565033.GACE_1073	5.548e-33	140.0	COG3177@1|root,arCOG03112@2157|Archaea,2Y7EM@28890|Euryarchaeota,246U1@183980|Archaeoglobi	183980|Archaeoglobi	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7092881_6	1232410.KI421413_gene512	6.546e-44	174.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,43S48@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TRAM domain	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
LZS3_k127_7092881_16	572546.Arcpr_0050	0.0009359	48.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
LZS3_k127_7092881_5	1047013.AQSP01000119_gene1318	6.051e-54	195.0	COG4843@1|root,COG4843@2|Bacteria,2NPKB@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
LZS3_k127_7092881_10	104355.XP_007863265.1	3.461e-25	113.0	COG0588@1|root,KOG0235@2759|Eukaryota,38MRY@33154|Opisthokonta,3P6MM@4751|Fungi,3V27B@5204|Basidiomycota,229YA@155619|Agaricomycetes,3H5DG@355688|Agaricomycetes incertae sedis	4751|Fungi	G	Phosphoglycerate mutase-like protein	-	GO:0003674,GO:0003824,GO:0004083,GO:0004331,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006109,GO:0006110,GO:0006140,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010562,GO:0010563,GO:0010675,GO:0010677,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019219,GO:0019220,GO:0019222,GO:0030808,GO:0030809,GO:0030811,GO:0030812,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031329,GO:0031330,GO:0034248,GO:0034416,GO:0042325,GO:0042326,GO:0042578,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043455,GO:0043456,GO:0043467,GO:0043470,GO:0043471,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045820,GO:0045912,GO:0045934,GO:0045935,GO:0045936,GO:0045937,GO:0045980,GO:0045981,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050308,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051193,GO:0051194,GO:0051195,GO:0051196,GO:0051197,GO:0051198,GO:0060255,GO:0062012,GO:0062013,GO:0062014,GO:0065007,GO:0080090,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1902031,GO:1903578,GO:1903579,GO:1905857,GO:2001169,GO:2001170	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
LZS3_k127_7092881_0	1454004.AW11_02750	0.0	1182.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria	1224|Proteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,PTS_EIIA_2
LZS3_k127_7092881_15	593750.Metfor_2881	0.0002006	48.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7092881_1	573063.Metin_1290	1.311e-112	374.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23QKG@183939|Methanococci	183939|Methanococci	S	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
LZS3_k127_7092881_7	391623.TERMP_00326	3.884e-40	162.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota,243WP@183968|Thermococci	183968|Thermococci	E	Thermophilic metalloprotease (M29)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
LZS3_k127_7239651_35	269799.Gmet_2469	2.425e-07	65.0	COG1520@1|root,COG4733@1|root,COG5306@1|root,COG1520@2|Bacteria,COG4733@2|Bacteria,COG5306@2|Bacteria,1P31B@1224|Proteobacteria,42VDF@68525|delta/epsilon subdivisions,2WRBJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,VWD,fn3
LZS3_k127_7239651_19	247490.KSU1_C1544	4.935e-22	114.0	COG2755@1|root,COG5306@1|root,COG2755@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	exbB2	-	3.4.14.5	ko:K01278,ko:K03561,ko:K12287	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
LZS3_k127_7239651_33	1121859.KB890754_gene1057	1.842e-07	66.0	COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia	976|Bacteroidetes	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_3,Laminin_G_3,Lipase_GDSL_2,fn3
LZS3_k127_7239651_13	572478.Vdis_1292	1.504e-33	142.0	COG0714@1|root,arCOG00441@2157|Archaea,2XPM4@28889|Crenarchaeota	28889|Crenarchaeota	S	ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
LZS3_k127_7239651_38	262724.TT_C0696	2.319e-05	56.0	COG2304@1|root,COG2304@2|Bacteria,1WIWZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
LZS3_k127_7239651_23	221027.JO40_01000	3.919e-16	87.0	COG2129@1|root,COG2129@2|Bacteria,2J78J@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG2129 phosphoesterase related to the Icc protein	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos_2
LZS3_k127_7239651_20	1123325.JHUV01000017_gene196	1.875e-18	94.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	nrdG	-	1.97.1.4,4.3.99.3	ko:K04069,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
LZS3_k127_7239651_11	931626.Awo_c35410	1.513e-37	151.0	COG0125@1|root,COG1982@1|root,COG0125@2|Bacteria,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,25VF6@186806|Eubacteriaceae	186801|Clostridia	E	Orn Lys Arg decarboxylase, major domain	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
LZS3_k127_7239651_24	5786.XP_003294396.1	7.727e-16	84.0	COG0237@1|root,2STE9@2759|Eukaryota,3XC8Z@554915|Amoebozoa	554915|Amoebozoa	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
LZS3_k127_7239651_6	744872.Spica_1020	6.69e-58	206.0	COG2131@1|root,COG2131@2|Bacteria,2J6UR@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
LZS3_k127_7239651_30	373994.Riv7116_3954	4.323e-09	61.0	COG1872@1|root,COG1872@2|Bacteria,1G935@1117|Cyanobacteria,1HPRR@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
LZS3_k127_7239651_17	420247.Msm_1354	1.587e-25	108.0	COG1594@1|root,arCOG00579@2157|Archaea,2XZ6S@28890|Euryarchaeota,23P4D@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
LZS3_k127_7239651_34	1047171.Mycgr3P67720	1.999e-07	61.0	COG0681@1|root,KOG3342@2759|Eukaryota,38Y2A@33154|Opisthokonta,3P0U2@4751|Fungi,3QU98@4890|Ascomycota,1ZYAV@147541|Dothideomycetes,3MJPJ@451867|Dothideomycetidae	4751|Fungi	U	Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum	SEC11	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005787,GO:0005789,GO:0006465,GO:0006508,GO:0006518,GO:0006605,GO:0006807,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0012505,GO:0015031,GO:0015833,GO:0016020,GO:0016485,GO:0016787,GO:0019538,GO:0031984,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0034641,GO:0042175,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051604,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071704,GO:0071705,GO:0072594,GO:0072599,GO:0098796,GO:0098827,GO:0140096,GO:1901564,GO:1902494,GO:1905368	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
LZS3_k127_7239651_16	521011.Mpal_1003	4.338e-26	117.0	COG1018@1|root,arCOG02200@2157|Archaea,2XVD3@28890|Euryarchaeota,2N9JH@224756|Methanomicrobia	224756|Methanomicrobia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
LZS3_k127_7239651_2	410358.Mlab_0710	1.493e-113	380.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
LZS3_k127_7239651_0	1343739.PAP_05820	1.098e-160	523.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
LZS3_k127_7239651_18	616991.JPOO01000003_gene767	1.342e-22	110.0	COG3930@1|root,COG3930@2|Bacteria,4NG5D@976|Bacteroidetes,1HZIT@117743|Flavobacteriia,23G1Q@178469|Arenibacter	976|Bacteroidetes	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704,FGase
LZS3_k127_7239651_26	1051632.TPY_3688	1.004e-13	85.0	COG1305@1|root,COG1305@2|Bacteria,1TT33@1239|Firmicutes,24B27@186801|Clostridia	186801|Clostridia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
LZS3_k127_7239651_22	1444712.BN1013_00368	1.309e-17	85.0	2ENCP@1|root,33G06@2|Bacteria,2JHC7@204428|Chlamydiae	204428|Chlamydiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7239651_15	927677.ALVU02000001_gene4063	4.264e-26	116.0	COG4430@1|root,COG4430@2|Bacteria,1G2ES@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
LZS3_k127_7239651_8	552811.Dehly_0476	1.323e-50	190.0	COG0428@1|root,COG0428@2|Bacteria,2G671@200795|Chloroflexi	200795|Chloroflexi	P	ZIP Zinc transporter	-	-	-	ko:K07238,ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11,2.A.5.5	-	-	Zip
LZS3_k127_7239651_39	9601.ENSPPYP00000008443	3.23e-05	54.0	COG0638@1|root,KOG0173@2759|Eukaryota,38CTY@33154|Opisthokonta,3BEBY@33208|Metazoa,3CUEU@33213|Bilateria,47Z2B@7711|Chordata,490US@7742|Vertebrata,3JC81@40674|Mammalia,35KJ5@314146|Euarchontoglires,4MBSM@9443|Primates,4MWTV@9604|Hominidae	33208|Metazoa	O	Proteasome beta subunits C terminal	PSMB10	GO:0000502,GO:0000902,GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0004175,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006955,GO:0006959,GO:0008150,GO:0008152,GO:0008233,GO:0008283,GO:0009056,GO:0009057,GO:0009653,GO:0009987,GO:0010498,GO:0016043,GO:0016579,GO:0016787,GO:0019538,GO:0019774,GO:0019941,GO:0030163,GO:0031974,GO:0031981,GO:0032502,GO:0032943,GO:0032989,GO:0032991,GO:0036211,GO:0042098,GO:0042110,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043632,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045321,GO:0046649,GO:0046651,GO:0048856,GO:0048869,GO:0050896,GO:0051603,GO:0070011,GO:0070013,GO:0070646,GO:0070647,GO:0070661,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369,GO:1990111	3.4.25.1	ko:K02733,ko:K02739	ko03050,map03050	M00337,M00340	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Pr_beta_C,Proteasome
LZS3_k127_7239651_41	391623.TERMP_01214	0.0001347	53.0	arCOG00381@1|root,arCOG00381@2157|Archaea,2Y7WG@28890|Euryarchaeota,245M1@183968|Thermococci	183968|Thermococci	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
LZS3_k127_7239651_5	688270.Celal_3758	8.36e-61	232.0	COG0075@1|root,COG0726@1|root,COG5492@1|root,COG0075@2|Bacteria,COG0726@2|Bacteria,COG5492@2|Bacteria,4PNT2@976|Bacteroidetes,1IKBJ@117743|Flavobacteriia,1F9TB@104264|Cellulophaga	976|Bacteroidetes	E	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7239651_31	4533.OB08G21360.1	1.306e-08	65.0	COG5274@1|root,KOG0537@2759|Eukaryota,37WIJ@33090|Viridiplantae,3GJQ6@35493|Streptophyta,3M0MG@4447|Liliopsida,3IIQC@38820|Poales	35493|Streptophyta	C	Belongs to the cytochrome b5 family	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
LZS3_k127_7239651_40	391587.KAOT1_08959	3.901e-05	51.0	2BW9M@1|root,32RJH@2|Bacteria,4NTHJ@976|Bacteroidetes,1I4PQ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7239651_3	583355.Caka_1764	1.967e-88	300.0	COG0701@1|root,COG0701@2|Bacteria,46VTG@74201|Verrucomicrobia,3K8S1@414999|Opitutae	414999|Opitutae	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
LZS3_k127_7239651_27	497964.CfE428DRAFT_4278	2.728e-12	78.0	COG2866@1|root,COG2866@2|Bacteria,46T00@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
LZS3_k127_7239651_1	1094980.Mpsy_2748	7.567e-156	503.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,2N99K@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	3.6.4.13	ko:K05592,ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
LZS3_k127_7239651_21	304371.MCP_1319	1.947e-18	88.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
LZS3_k127_7239651_25	416591.Tlet_0328	1.033e-15	88.0	COG0476@1|root,COG0476@2|Bacteria,2GD2Q@200918|Thermotogae	200918|Thermotogae	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
LZS3_k127_7239651_29	314282.PCNPT3_11250	2.987e-11	77.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,2QI28@267894|Psychromonadaceae	1236|Gammaproteobacteria	M	Transglycosylase SLT domain	ltg	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
LZS3_k127_7239651_4	1151117.AJLF01000001_gene771	3.346e-63	232.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,242NB@183968|Thermococci	183968|Thermococci	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
LZS3_k127_7239651_9	1042877.GQS_07170	4.992e-45	173.0	COG1637@1|root,arCOG01304@2157|Archaea,2XUC8@28890|Euryarchaeota,243KJ@183968|Thermococci	183968|Thermococci	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
LZS3_k127_7239651_12	357808.RoseRS_3812	7.437e-37	148.0	COG1994@1|root,COG1994@2|Bacteria,2GAEP@200795|Chloroflexi,375U8@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7239651_28	1041930.Mtc_1042	7.754e-12	76.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_11,HTH_24
LZS3_k127_7239651_36	1123276.KB893251_gene3562	3.207e-07	62.0	COG1522@1|root,COG1522@2|Bacteria,4NNVN@976|Bacteroidetes,47Q1N@768503|Cytophagia	976|Bacteroidetes	K	helix_turn_helix ASNC type	-	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
LZS3_k127_7239651_10	1070774.J07HN4v3_02848	2.141e-39	154.0	COG0778@1|root,arCOG00288@2157|Archaea,2XW9R@28890|Euryarchaeota,23UAA@183963|Halobacteria	183963|Halobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
LZS3_k127_7239651_7	658088.HMPREF0987_01928	1.781e-56	209.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,27IRE@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
LZS3_k127_7239651_37	1220534.B655_1190	1.663e-05	51.0	arCOG05048@1|root,arCOG05048@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
LZS3_k127_7239651_14	1499967.BAYZ01000116_gene3149	6.505e-32	131.0	COG4902@1|root,COG4902@2|Bacteria	2|Bacteria	-	-	yhjR	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	DUF2202,Rubrerythrin
LZS3_k127_7239651_32	555079.Toce_1004	1.825e-07	58.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,42FNE@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM multi antimicrobial extrusion protein MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
LZS3_k127_7344139_16	1459636.NTE_03037	2.697e-17	84.0	COG2220@1|root,arCOG00497@2157|Archaea	2157|Archaea	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
LZS3_k127_7344139_12	67352.JODS01000002_gene1348	4.765e-35	140.0	COG1896@1|root,COG1896@2|Bacteria,2I8SJ@201174|Actinobacteria	201174|Actinobacteria	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
LZS3_k127_7344139_10	157072.XP_008873508.1	9.62e-47	175.0	COG2178@1|root,KOG3066@2759|Eukaryota	2759|Eukaryota	J	Translin-associated protein X	-	-	-	-	-	-	-	-	-	-	-	-	Translin,zf-BED
LZS3_k127_7344139_6	304371.MCP_2972	3.184e-107	379.0	COG4962@1|root,arCOG01818@2157|Archaea,2XTN5@28890|Euryarchaeota,2N9AG@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
LZS3_k127_7344139_11	192952.MM_2297	6.592e-45	186.0	arCOG01814@1|root,arCOG01814@2157|Archaea,2XT74@28890|Euryarchaeota,2N90N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7344139_24	1335760.ASTG01000006_gene1343	0.0001259	48.0	2EFVT@1|root,339N0@2|Bacteria,1NJX8@1224|Proteobacteria,2UJ01@28211|Alphaproteobacteria,2K78R@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7344139_7	351160.RCIX1267	1.615e-102	353.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
LZS3_k127_7344139_1	309799.DICTH_1585	4.567e-166	534.0	COG0215@1|root,COG0215@2|Bacteria	2|Bacteria	J	cysteine-tRNA ligase activity	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
LZS3_k127_7344139_0	1041930.Mtc_1018	1.311e-262	831.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
LZS3_k127_7344139_3	237368.SCABRO_03926	6.625e-144	469.0	COG0173@1|root,COG0173@2|Bacteria,2IX6U@203682|Planctomycetes	203682|Planctomycetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
LZS3_k127_7344139_18	1123487.KB892866_gene1654	3.74e-13	76.0	COG2606@1|root,COG2606@2|Bacteria,1R9YR@1224|Proteobacteria,2VSFT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ybak prolyl-trna synthetase associated	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
LZS3_k127_7344139_5	439481.Aboo_0846	2.658e-128	423.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,3F37W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	class II (D K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
LZS3_k127_7344139_19	331113.SNE_A08470	1.685e-11	70.0	COG0537@1|root,COG0537@2|Bacteria,2JG1P@204428|Chlamydiae	204428|Chlamydiae	FG	trans-aconitate 2-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	HIT
LZS3_k127_7344139_8	386456.JQKN01000008_gene1390	1.184e-69	251.0	COG0420@1|root,arCOG00397@2157|Archaea,2XWH1@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
LZS3_k127_7344139_23	697329.Rumal_0776	7.089e-07	60.0	28HHD@1|root,33UVR@2|Bacteria,1VV5S@1239|Firmicutes,250KW@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
LZS3_k127_7344139_14	523845.AQXV01000025_gene1504	2.842e-29	131.0	COG0668@1|root,arCOG01569@2157|Archaea,2XVK0@28890|Euryarchaeota,23QTX@183939|Methanococci	183939|Methanococci	M	PFAM MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
LZS3_k127_7344139_15	1185652.USDA257_c11860	3.322e-27	124.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2UPNC@28211|Alphaproteobacteria,4BARS@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
LZS3_k127_7344139_13	877455.Metbo_0108	4.051e-33	138.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,23NY2@183925|Methanobacteria	183925|Methanobacteria	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
LZS3_k127_7344139_20	1123263.AUKY01000002_gene92	1.892e-11	72.0	COG4478@1|root,COG4478@2|Bacteria,1VA1P@1239|Firmicutes,3VR59@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
LZS3_k127_7344139_2	604354.TSIB_0669	8.827e-163	532.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,242JH@183968|Thermococci	183968|Thermococci	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
LZS3_k127_7344139_21	1094980.Mpsy_0247	3.51e-11	68.0	arCOG11378@1|root,arCOG11378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7344139_25	243232.MJ_0789	0.0002309	48.0	arCOG05051@1|root,arCOG05051@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
LZS3_k127_7344139_4	309800.C498_14448	2.966e-133	468.0	COG0417@1|root,COG1372@1|root,arCOG00328@2157|Archaea,arCOG03145@2157|Archaea,2XU1K@28890|Euryarchaeota,23RXE@183963|Halobacteria	183963|Halobacteria	L	COG0417 DNA polymerase elongation subunit (family B)	polB1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing
LZS3_k127_7344139_17	1122947.FR7_3572	5.238e-16	85.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,4H4EZ@909932|Negativicutes	909932|Negativicutes	L	Hydrolase, NUDIX family	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
LZS3_k127_7344139_22	318464.IO99_06185	6.31e-10	64.0	COG1051@1|root,COG1051@2|Bacteria,1VED7@1239|Firmicutes,25BD4@186801|Clostridia	186801|Clostridia	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
LZS3_k127_7344139_9	908612.HMPREF9720_0153	1.329e-53	197.0	COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes,2G0CZ@200643|Bacteroidia,22UN6@171550|Rikenellaceae	976|Bacteroidetes	G	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
LZS3_k127_7349642_11	797114.C475_11059	0.0002886	51.0	COG0668@1|root,arCOG01570@2157|Archaea,2XUMM@28890|Euryarchaeota,23SS1@183963|Halobacteria	183963|Halobacteria	M	COG0668 Small-conductance mechanosensitive channel	mscS2	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
LZS3_k127_7349642_8	742727.HMPREF9447_03999	4.127e-15	89.0	COG3408@1|root,COG3408@2|Bacteria,4NF09@976|Bacteroidetes,2FQZM@200643|Bacteroidia,4AMWC@815|Bacteroidaceae	976|Bacteroidetes	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
LZS3_k127_7349642_1	1379270.AUXF01000003_gene3433	6.86e-97	327.0	COG1208@1|root,COG1208@2|Bacteria,1ZSYR@142182|Gemmatimonadetes	142182|Gemmatimonadetes	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
LZS3_k127_7349642_6	679926.Mpet_0128	2.46e-19	97.0	arCOG11437@1|root,arCOG11437@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7349642_2	693661.Arcve_1224	5.519e-84	291.0	COG1085@1|root,arCOG00420@2157|Archaea,2Y3A2@28890|Euryarchaeota	28890|Euryarchaeota	C	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7349642_7	222984.JNCS01000001_gene2068	3.866e-18	88.0	COG2154@1|root,arCOG02939@2157|Archaea,2XYAK@28890|Euryarchaeota,23WHS@183963|Halobacteria	183963|Halobacteria	H	COG2154 Pterin-4a-carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
LZS3_k127_7349642_5	1094980.Mpsy_2989	5.73e-20	92.0	arCOG07473@1|root,arCOG07473@2157|Archaea,2Y1CW@28890|Euryarchaeota,2NB9V@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7349642_10	634498.mru_2118	4.154e-06	56.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,23P1Z@183925|Methanobacteria	183925|Methanobacteria	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
LZS3_k127_7349642_3	304371.MCP_2363	2.734e-70	249.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
LZS3_k127_7349642_0	1122169.AREN01000001_gene963	8.068e-153	495.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1JDV0@118969|Legionellales	118969|Legionellales	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	rocG	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
LZS3_k127_7349642_4	351160.RCIX928	3.729e-30	126.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2N9PE@224756|Methanomicrobia	224756|Methanomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
LZS3_k127_7634796_6	383372.Rcas_0295	3.827e-72	252.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia	32061|Chloroflexia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
LZS3_k127_7634796_4	315749.Bcer98_3276	3.08e-88	301.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,4HB0Z@91061|Bacilli,1ZC27@1386|Bacillus	91061|Bacilli	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0004470,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
LZS3_k127_7634796_1	383372.Rcas_0160	2.119e-152	490.0	COG0192@1|root,COG0192@2|Bacteria,2G5X0@200795|Chloroflexi,37571@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
LZS3_k127_7634796_11	247490.KSU1_C0658	0.000752	48.0	2905C@1|root,2ZMV8@2|Bacteria,2J46F@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7634796_5	69014.TK1332	1.062e-72	277.0	COG1204@1|root,COG1372@1|root,arCOG00553@2157|Archaea,arCOG03145@2157|Archaea,2XSV4@28890|Euryarchaeota,243RC@183968|Thermococci	183968|Thermococci	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
LZS3_k127_7634796_9	491952.Mar181_2681	2.399e-15	89.0	COG0462@1|root,COG0462@2|Bacteria,1R5PV@1224|Proteobacteria,1RQRB@1236|Gammaproteobacteria,1XN1C@135619|Oceanospirillales	135619|Oceanospirillales	EF	pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
LZS3_k127_7634796_8	593117.TGAM_0865	3.444e-50	183.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,243T7@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
LZS3_k127_7634796_2	927658.AJUM01000017_gene3097	2.644e-119	396.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	bamJ	-	-	-	-	-	-	-	-	-	-	iSB619.SA_RS10050	Aminotran_1_2
LZS3_k127_7634796_3	7918.ENSLOCP00000018933	1.571e-115	393.0	COG0438@1|root,KOG3742@2759|Eukaryota,38BSH@33154|Opisthokonta,3BAK5@33208|Metazoa,3CSXT@33213|Bilateria,4834T@7711|Chordata,48V7M@7742|Vertebrata,49U64@7898|Actinopterygii	33208|Metazoa	G	Glycogen starch synthase	GYS2	GO:0000271,GO:0000272,GO:0003674,GO:0003824,GO:0004373,GO:0005488,GO:0005515,GO:0005536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005938,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0005980,GO:0005981,GO:0006073,GO:0006091,GO:0006109,GO:0006112,GO:0006914,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008194,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009250,GO:0009251,GO:0009267,GO:0009605,GO:0009743,GO:0009744,GO:0009746,GO:0009749,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0009991,GO:0010033,GO:0010604,GO:0010675,GO:0010676,GO:0010906,GO:0010907,GO:0015629,GO:0015980,GO:0016051,GO:0016052,GO:0016236,GO:0016740,GO:0016757,GO:0016758,GO:0016772,GO:0019222,GO:0030246,GO:0030863,GO:0030864,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0031667,GO:0031668,GO:0031669,GO:0032881,GO:0033554,GO:0033692,GO:0034284,GO:0034285,GO:0034637,GO:0034645,GO:0035251,GO:0036094,GO:0042221,GO:0042594,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043265,GO:0043467,GO:0043470,GO:0043471,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044464,GO:0045819,GO:0045913,GO:0046527,GO:0046983,GO:0048029,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0060255,GO:0061547,GO:0061723,GO:0061912,GO:0061919,GO:0062012,GO:0062013,GO:0065007,GO:0070873,GO:0070875,GO:0070887,GO:0071310,GO:0071322,GO:0071324,GO:0071329,GO:0071496,GO:0071704,GO:0071944,GO:0080090,GO:0099568,GO:1901575,GO:1901576,GO:1901700,GO:1901701	2.4.1.11	ko:K00693	ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3	-	Glycogen_syn
LZS3_k127_7634796_0	411464.DESPIG_00921	5.302e-164	526.0	COG1449@1|root,COG1449@2|Bacteria,1R8JX@1224|Proteobacteria,42QA5@68525|delta/epsilon subdivisions,2WMM5@28221|Deltaproteobacteria,2M9GJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
LZS3_k127_7634796_7	866536.Belba_1559	3.585e-58	206.0	COG0297@1|root,COG0297@2|Bacteria,4PKP8@976|Bacteroidetes	976|Bacteroidetes	G	Glycosyltransferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
LZS3_k127_7658201_0	246194.CHY_1579	1.421e-228	726.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,42EQA@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
LZS3_k127_7658201_16	186497.PF1392	5.65e-57	207.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
LZS3_k127_7658201_6	309807.SRU_1720	1.669e-92	309.0	COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1FK37@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
LZS3_k127_7658201_40	1444712.BN1013_02076	4.235e-07	60.0	COG2890@1|root,COG2890@2|Bacteria	2|Bacteria	J	protein-(glutamine-N5) methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	MTS
LZS3_k127_7658201_7	112098.XP_008616097.1	1.202e-83	286.0	COG1798@1|root,KOG3123@2759|Eukaryota	2759|Eukaryota	J	diphthine synthase activity	DPH5	GO:0003674,GO:0003824,GO:0004164,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0044424,GO:0044444,GO:0044464,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.1.1.314	ko:K00586,ko:K07870,ko:K17081	ko04137,ko04214,map04137,map04214	-	R11165	RC00003,RC03382	ko00000,ko00001,ko01000,ko03012,ko03029,ko04031,ko04147	-	-	iMM904.YLR172C,iND750.YLR172C	TP_methylase
LZS3_k127_7658201_38	323259.Mhun_0943	7.411e-10	71.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7658201_30	647113.Metok_0022	1.18e-23	105.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,23R5H@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
LZS3_k127_7658201_10	224719.Abm4_0258	8.771e-69	245.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,23NKW@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
LZS3_k127_7658201_26	573063.Metin_1008	7.448e-33	135.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,23Q2Y@183939|Methanococci	183939|Methanococci	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
LZS3_k127_7658201_34	759914.BP951000_1308	9.59e-14	74.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	iscA1	-	6.3.5.11,6.3.5.9	ko:K02224,ko:K13628,ko:K15724	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000,ko03016	-	-	-	Fe-S_biosyn
LZS3_k127_7658201_3	1151292.QEW_0053	8.12e-148	482.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,25S74@186804|Peptostreptococcaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
LZS3_k127_7658201_11	272844.PAB1943	4.738e-68	244.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2438J@183968|Thermococci	183968|Thermococci	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.5	ko:K18105	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
LZS3_k127_7658201_25	906968.Trebr_1133	6.068e-34	134.0	COG0221@1|root,COG0221@2|Bacteria,2JAUQ@203691|Spirochaetes	203691|Spirochaetes	C	-acetyltransferase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	-
LZS3_k127_7658201_5	6334.EFV57412	1.038e-109	368.0	COG0731@1|root,KOG1160@2759|Eukaryota,38C7H@33154|Opisthokonta,3BD3N@33208|Metazoa,3CYJS@33213|Bilateria	33208|Metazoa	C	tRNA-4-demethylwyosine synthase activity	TYW1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Flavodoxin_1,Radical_SAM,Wyosine_form
LZS3_k127_7658201_9	269799.Gmet_0379	4.734e-69	248.0	COG3872@1|root,COG3872@2|Bacteria,1RCB0@1224|Proteobacteria,42R3I@68525|delta/epsilon subdivisions,2WMZR@28221|Deltaproteobacteria,43U2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
LZS3_k127_7658201_33	69014.TK1195	1.577e-17	88.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,244ED@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
LZS3_k127_7658201_29	1343739.PAP_00245	5.695e-26	116.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,243FW@183968|Thermococci	183968|Thermococci	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
LZS3_k127_7658201_37	114615.BRADO0721	6.208e-12	78.0	COG3263@1|root,COG3263@2|Bacteria,1MVKV@1224|Proteobacteria,2TSZJ@28211|Alphaproteobacteria,3JR2B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Transporter associated domain	cvrA	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	CorC_HlyC,Na_H_Exchanger
LZS3_k127_7658201_19	439481.Aboo_0511	6.422e-47	185.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,3F2HM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
LZS3_k127_7658201_24	186497.PF0173	4.39e-34	146.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,242S8@183968|Thermococci	183968|Thermococci	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
LZS3_k127_7658201_15	634498.mru_1722	2.244e-61	233.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,23NSV@183925|Methanobacteria	183925|Methanobacteria	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
LZS3_k127_7658201_41	1227360.C176_02309	1.727e-06	58.0	COG0500@1|root,COG2226@2|Bacteria,1V4RW@1239|Firmicutes,4HIF0@91061|Bacilli,26GRW@186818|Planococcaceae	91061|Bacilli	Q	Hypothetical methyltransferase	yodH	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
LZS3_k127_7658201_27	88036.EFJ23279	7.735e-31	130.0	COG1590@1|root,KOG0379@1|root,KOG0379@2759|Eukaryota,KOG1228@2759|Eukaryota,388PF@33090|Viridiplantae,3GXYE@35493|Streptophyta	35493|Streptophyta	S	Methyltransferase TYW3	-	-	2.1.1.282	ko:K15450	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Kelch_4,TYW3
LZS3_k127_7658201_35	335543.Sfum_1292	2.101e-13	79.0	COG2263@1|root,COG2263@2|Bacteria	2|Bacteria	J	DNA repair	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0036260,GO:0036261,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071164,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
LZS3_k127_7658201_20	694429.Pyrfu_0214	2.86e-44	169.0	COG0638@1|root,arCOG00970@2157|Archaea,2XQBK@28889|Crenarchaeota	28889|Crenarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB2	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
LZS3_k127_7658201_2	195522.BD01_2266	1.471e-198	636.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,243E8@183968|Thermococci	183968|Thermococci	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
LZS3_k127_7658201_23	679926.Mpet_0688	1.427e-37	148.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,MarR_2,NTP_transf_2
LZS3_k127_7658201_32	679926.Mpet_0689	2.31e-18	92.0	COG1895@1|root,arCOG02123@2157|Archaea	2157|Archaea	S	protein related to C-terminal domain of eukaryotic chaperone, SACSIN	-	-	-	ko:K09132	-	-	-	-	ko00000	-	-	-	HEPN
LZS3_k127_7658201_36	521011.Mpal_2380	2.662e-12	68.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,2NA2R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
LZS3_k127_7658201_12	304371.MCP_2626	6.899e-64	228.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2N93P@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
LZS3_k127_7658201_13	1220534.B655_1251	3.713e-63	225.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,23NWI@183925|Methanobacteria	183925|Methanobacteria	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
LZS3_k127_7658201_18	1220534.B655_1252	1.211e-52	197.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,23P36@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
LZS3_k127_7658201_17	572546.Arcpr_0510	1.008e-53	198.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,246MV@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosome maturation protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
LZS3_k127_7658201_8	573064.Mefer_1376	3.164e-69	242.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23QEI@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
LZS3_k127_7658201_39	523845.AQXV01000055_gene16	1.796e-08	60.0	COG1369@1|root,arCOG01365@2157|Archaea,2Y67S@28890|Euryarchaeota,23R0M@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
LZS3_k127_7658201_42	1123354.AUDR01000012_gene1610	6.125e-05	48.0	COG4575@1|root,COG4575@2|Bacteria,1N3P5@1224|Proteobacteria,2VU7A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF883)	elaB	-	-	-	-	-	-	-	-	-	-	-	DUF883
LZS3_k127_7658201_1	1041930.Mtc_0487	4.353e-222	715.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
LZS3_k127_7658201_14	485913.Krac_10545	7.885e-62	224.0	COG0528@1|root,COG0528@2|Bacteria	2|Bacteria	F	UMP kinase activity	mosB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914	2.7.4.22	ko:K00947,ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
LZS3_k127_7658201_31	339860.Msp_0360	3.311e-21	105.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,23NXE@183925|Methanobacteria	183925|Methanobacteria	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
LZS3_k127_7658201_21	1519464.HY22_12475	5.734e-43	168.0	COG2404@1|root,COG2404@2|Bacteria,1FEPM@1090|Chlorobi	1090|Chlorobi	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7658201_4	368407.Memar_2432	1.201e-116	390.0	COG1109@1|root,arCOG00767@2157|Archaea,2XVBA@28890|Euryarchaeota	28890|Euryarchaeota	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	manB	GO:0003674,GO:0003824,GO:0004615,GO:0016853,GO:0016866,GO:0016868	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
LZS3_k127_7658201_28	1283299.AUKG01000001_gene1924	1.503e-27	118.0	COG0662@1|root,COG0662@2|Bacteria,2GXUC@201174|Actinobacteria,4CT1G@84995|Rubrobacteria	84995|Rubrobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	MannoseP_isomer
LZS3_k127_7658201_22	186497.PF1728	4.457e-40	155.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,243QQ@183968|Thermococci	183968|Thermococci	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
LZS3_k127_7704381_31	269797.Mbar_A2662	4.239e-36	140.0	COG0610@1|root,arCOG00878@2157|Archaea,2XSZ2@28890|Euryarchaeota,2N95V@224756|Methanomicrobia	224756|Methanomicrobia	V	Domain of unknown function (DUF3387)	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
LZS3_k127_7704381_25	290317.Cpha266_1761	1.52e-47	177.0	COG2003@1|root,COG2003@2|Bacteria,1FEM3@1090|Chlorobi	1090|Chlorobi	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
LZS3_k127_7704381_59	390235.PputW619_1348	8.285e-08	55.0	2CIZN@1|root,33BAP@2|Bacteria,1NJHF@1224|Proteobacteria,1SHYB@1236|Gammaproteobacteria,1YZCA@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Superinfection immunity protein	-	-	-	-	-	-	-	-	-	-	-	-	Imm_superinfect,SHOCT
LZS3_k127_7704381_4	563040.Saut_2049	1.407e-142	459.0	COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,42MTT@68525|delta/epsilon subdivisions,2YM9N@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_RhuM
LZS3_k127_7704381_47	118005.AWNK01000005_gene1511	6.696e-17	85.0	COG3617@1|root,COG3617@2|Bacteria	2|Bacteria	K	BRO family, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bro-N
LZS3_k127_7704381_58	1227739.Hsw_1800	2.034e-10	72.0	COG1913@1|root,COG1913@2|Bacteria,4NQPV@976|Bacteroidetes,47X0R@768503|Cytophagia	976|Bacteroidetes	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
LZS3_k127_7704381_51	573064.Mefer_1573	8.691e-15	85.0	arCOG05051@1|root,arCOG05051@2157|Archaea,2Y15G@28890|Euryarchaeota,23RBZ@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
LZS3_k127_7704381_38	647113.Metok_0123	1.829e-23	115.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
LZS3_k127_7704381_46	445973.CLOBAR_00338	4.91e-17	90.0	COG0726@1|root,COG0726@2|Bacteria,1UZGG@1239|Firmicutes,249C9@186801|Clostridia,25QTV@186804|Peptostreptococcaceae	186801|Clostridia	G	Polysaccharide deacetylase	pdaB	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
LZS3_k127_7704381_55	192952.MM_2550	1.318e-11	67.0	arCOG05071@1|root,arCOG05071@2157|Archaea,2Y0VX@28890|Euryarchaeota,2NBB9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2683)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2683
LZS3_k127_7704381_49	243232.MJ_1173	1.207e-15	79.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y07R@28890|Euryarchaeota,23R7I@183939|Methanococci	183939|Methanococci	K	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
LZS3_k127_7704381_13	391598.FBBAL38_08809	1.648e-84	305.0	COG1470@1|root,COG2133@1|root,COG2304@1|root,COG2706@1|root,COG3209@1|root,COG3291@1|root,COG3420@1|root,COG4733@1|root,COG5279@1|root,COG1470@2|Bacteria,COG2133@2|Bacteria,COG2304@2|Bacteria,COG2706@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,COG5279@2|Bacteria,4P2UU@976|Bacteroidetes,1HYAX@117743|Flavobacteriia	976|Bacteroidetes	DZ	TIGRFAM Bacterial surface protein 26-residue repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,DUF285,TIG,TSP_3
LZS3_k127_7704381_61	571166.KI421509_gene2360	1.355e-06	54.0	2CKQA@1|root,33F1D@2|Bacteria,1NNBI@1224|Proteobacteria,2UMHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7704381_9	195522.BD01_1821	5.595e-106	355.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
LZS3_k127_7704381_48	877455.Metbo_0344	4.619e-16	82.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
LZS3_k127_7704381_42	644281.MFS40622_0720	1.009e-20	98.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,23R23@183939|Methanococci	183939|Methanococci	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
LZS3_k127_7704381_18	1163730.FFONT_0459	5.839e-57	204.0	COG0052@1|root,arCOG04245@2157|Archaea,2XPP9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
LZS3_k127_7704381_62	1028307.EAE_02380	1.26e-05	57.0	COG1522@1|root,COG1522@2|Bacteria,1REGJ@1224|Proteobacteria,1RZND@1236|Gammaproteobacteria,3X3FM@547|Enterobacter	1236|Gammaproteobacteria	K	helix_turn_helix ASNC type	putR	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
LZS3_k127_7704381_21	877455.Metbo_0565	3.83e-52	202.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
LZS3_k127_7704381_60	1382230.ASAP_0102	3.19e-07	62.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,2JPBP@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
LZS3_k127_7704381_26	1041930.Mtc_0662	5.492e-45	171.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
LZS3_k127_7704381_34	485916.Dtox_0215	1.326e-28	132.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,266W1@186807|Peptococcaceae	186801|Clostridia	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
LZS3_k127_7704381_27	926692.AZYG01000036_gene2548	5.086e-42	162.0	COG2109@1|root,COG2109@2|Bacteria,1V70U@1239|Firmicutes,24JNB@186801|Clostridia,3WAUW@53433|Halanaerobiales	186801|Clostridia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
LZS3_k127_7704381_2	673860.AciM339_1486	7.507e-163	537.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,3F2JF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
LZS3_k127_7704381_0	290318.Cvib_1199	0.0	1262.0	COG0209@1|root,COG0209@2|Bacteria,1FD9Z@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC
LZS3_k127_7704381_16	1408422.JHYF01000008_gene3569	1.501e-58	215.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
LZS3_k127_7704381_56	1227497.C491_02450	1.88e-11	70.0	arCOG06355@1|root,arCOG06355@2157|Archaea,2XXE7@28890|Euryarchaeota,23WV4@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
LZS3_k127_7704381_7	1047013.AQSP01000110_gene67	1.594e-126	420.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
LZS3_k127_7704381_41	348780.NP_0864A	5.988e-21	105.0	COG0116@1|root,arCOG00048@2157|Archaea,2XV6N@28890|Euryarchaeota	28890|Euryarchaeota	J	RNA methylase	trm14	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.256	ko:K16318	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
LZS3_k127_7704381_35	269797.Mbar_A0890	1.298e-27	121.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
LZS3_k127_7704381_53	768672.Desfe_0098	2.56e-13	77.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
LZS3_k127_7704381_50	523841.HFX_1458	1.97e-15	80.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,23W5Q@183963|Halobacteria	183963|Halobacteria	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC,UBA_4
LZS3_k127_7704381_39	1120948.KB903218_gene2158	2.324e-23	104.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	pimE	GO:0000026,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.7.53,3.6.1.13,3.6.1.55	ko:K01515,ko:K03574,ko:K13669,ko:K19710	ko00230,map00230	-	R00126,R01054,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000,ko01003,ko03400	-	GT87	-	GT87,NUDIX
LZS3_k127_7704381_52	351160.RCIX1274	1.489e-14	82.0	COG0640@1|root,arCOG01686@2157|Archaea,2XX9R@28890|Euryarchaeota,2N9WK@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
LZS3_k127_7704381_54	234267.Acid_1194	6.823e-12	71.0	COG4911@1|root,COG4911@2|Bacteria,3Y4VB@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
LZS3_k127_7704381_22	247490.KSU1_C0048	1.1e-50	198.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
LZS3_k127_7704381_33	1157490.EL26_06945	2.349e-31	138.0	COG0312@1|root,COG0312@2|Bacteria,1V3G5@1239|Firmicutes	1239|Firmicutes	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
LZS3_k127_7704381_14	880072.Desac_2326	4.982e-82	289.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria,2MS6P@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
LZS3_k127_7704381_30	504472.Slin_1051	9.115e-38	147.0	COG0262@1|root,COG0262@2|Bacteria,4NQ2Y@976|Bacteroidetes,47Q9G@768503|Cytophagia	976|Bacteroidetes	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	2TM,DHFR_1
LZS3_k127_7704381_6	926562.Oweho_2964	1.127e-126	412.0	COG0207@1|root,COG0207@2|Bacteria,4NEC2@976|Bacteroidetes,1HX2F@117743|Flavobacteriia,2PA77@246874|Cryomorphaceae	976|Bacteroidetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
LZS3_k127_7704381_3	351627.Csac_2061	1.421e-150	487.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,42F68@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
LZS3_k127_7704381_19	1521187.JPIM01000013_gene2751	1.518e-56	207.0	COG1194@1|root,COG1194@2|Bacteria,2G62P@200795|Chloroflexi,37573@32061|Chloroflexia	32061|Chloroflexia	L	PFAM helix-hairpin-helix motif	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
LZS3_k127_7704381_10	426368.MmarC7_0254	1.676e-104	344.0	COG0708@1|root,arCOG02207@2157|Archaea,2XVJ5@28890|Euryarchaeota,23QN3@183939|Methanococci	183939|Methanococci	L	PFAM Endonuclease exonuclease phosphatase	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
LZS3_k127_7704381_20	926561.KB900618_gene192	1.008e-53	197.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,3WC30@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM channel protein, hemolysin III family	yqfA	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
LZS3_k127_7704381_43	768704.Desmer_0120	8.997e-20	94.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,2632C@186807|Peptococcaceae	186801|Clostridia	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
LZS3_k127_7704381_1	247490.KSU1_C0123	7.674e-197	621.0	COG0151@1|root,COG0151@2|Bacteria	2|Bacteria	F	phosphoribosylamine-glycine ligase activity	purD	-	6.3.4.13,6.3.5.5	ko:K01945,ko:K01955	ko00230,ko00240,ko00250,ko01100,ko01110,ko01130,map00230,map00240,map00250,map01100,map01110,map01130	M00048,M00051	R00256,R00575,R01395,R04144,R10948,R10949	RC00002,RC00010,RC00043,RC00090,RC00166,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,GARS_A,GARS_C,GARS_N
LZS3_k127_7704381_45	1121405.dsmv_0230	3.071e-17	94.0	COG0189@1|root,COG0189@2|Bacteria,1QW21@1224|Proteobacteria,42N8W@68525|delta/epsilon subdivisions,2WK1R@28221|Deltaproteobacteria,2MI6Y@213118|Desulfobacterales	28221|Deltaproteobacteria	HJ	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
LZS3_k127_7704381_24	879212.DespoDRAFT_01584	7.156e-50	192.0	COG0019@1|root,COG0019@2|Bacteria,1R96G@1224|Proteobacteria,42P87@68525|delta/epsilon subdivisions,2WJD9@28221|Deltaproteobacteria,2MJ7I@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Orn DAP Arg decarboxylase 2	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
LZS3_k127_7704381_36	1095769.CAHF01000015_gene2769	1.463e-25	113.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VSZY@28216|Betaproteobacteria,474FQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
LZS3_k127_7704381_23	584708.Apau_0482	2.891e-50	183.0	COG1528@1|root,COG1528@2|Bacteria,3TB3G@508458|Synergistetes	508458|Synergistetes	P	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
LZS3_k127_7704381_15	439235.Dalk_3514	1.674e-68	236.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2MN20@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
LZS3_k127_7704381_29	593117.TGAM_1046	2.17e-38	153.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2434V@183968|Thermococci	183968|Thermococci	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N,Rad1
LZS3_k127_7704381_65	604354.TSIB_0017	0.0007293	49.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
LZS3_k127_7704381_40	351160.RCIX2513	2.795e-21	100.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_7704381_44	351160.RCIX2512	1.54e-18	91.0	COG1895@1|root,arCOG02123@2157|Archaea	2157|Archaea	S	protein related to C-terminal domain of eukaryotic chaperone, SACSIN	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
LZS3_k127_7704381_11	573063.Metin_0743	8.43e-102	348.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,23Q9B@183939|Methanococci	183939|Methanococci	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
LZS3_k127_7704381_63	41431.PCC8801_4429	6.91e-05	53.0	COG2968@1|root,COG2968@2|Bacteria,1G07D@1117|Cyanobacteria,3KGUI@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
LZS3_k127_7704381_28	768672.Desfe_0599	2.462e-41	164.0	COG1184@1|root,arCOG01124@2157|Archaea,2XPZN@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
LZS3_k127_7704381_8	1026882.MAMP_02484	2.184e-123	412.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,46219@72273|Thiotrichales	72273|Thiotrichales	F	Pyrimidine nucleoside phosphorylase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
LZS3_k127_7704381_5	269797.Mbar_A0902	6.255e-140	457.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
LZS3_k127_7704381_12	647113.Metok_1475	3.452e-95	327.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,23Q9Q@183939|Methanococci	183939|Methanococci	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
LZS3_k127_7704381_37	1094466.KQS_12885	2.341e-25	113.0	COG0527@1|root,COG0527@2|Bacteria,4NJDY@976|Bacteroidetes,1HYZX@117743|Flavobacteriia,2NSWJ@237|Flavobacterium	976|Bacteroidetes	E	Aspartate kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7704381_32	643648.Slip_1597	6.256e-33	148.0	COG4808@1|root,COG4808@2|Bacteria,1VUWM@1239|Firmicutes,250BH@186801|Clostridia	186801|Clostridia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7704381_17	551275.KB899544_gene1381	3.321e-58	214.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,43WKT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
LZS3_k127_7704381_57	1121472.AQWN01000008_gene1885	1.073e-10	68.0	2EBKA@1|root,335KQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_7894810_0	1151117.AJLF01000002_gene24	4.765e-108	359.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,243K5@183968|Thermococci	183968|Thermococci	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	-	ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
LZS3_k127_7894810_7	456442.Mboo_1089	2.72e-09	64.0	arCOG05152@1|root,arCOG05152@2157|Archaea,2XZHZ@28890|Euryarchaeota,2N9VI@224756|Methanomicrobia	224756|Methanomicrobia	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5
LZS3_k127_7894810_1	267377.MMP0484	1.715e-105	362.0	COG0475@1|root,arCOG01955@2157|Archaea,2XWIX@28890|Euryarchaeota,23RH1@183939|Methanococci	183939|Methanococci	P	PFAM TrkA-N domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
LZS3_k127_7894810_4	269797.Mbar_A1362	3.115e-12	70.0	COG1534@1|root,arCOG01346@2157|Archaea,2Y6W9@28890|Euryarchaeota,2NA5I@224756|Methanomicrobia	224756|Methanomicrobia	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
LZS3_k127_7894810_8	579137.Metvu_1707	0.0008896	52.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,23QS3@183939|Methanococci	183939|Methanococci	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
LZS3_k127_7894810_3	439481.Aboo_0131	3.84e-25	115.0	COG1708@1|root,COG1895@1|root,arCOG01204@2157|Archaea,arCOG02123@2157|Archaea,2Y5D9@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA polymerase, beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_7894810_6	1042877.GQS_06950	4.3e-10	71.0	COG2064@1|root,arCOG01811@2157|Archaea,2Y68E@28890|Euryarchaeota,243AB@183968|Thermococci	183968|Thermococci	N	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
LZS3_k127_7894810_5	224719.Abm4_0274	6.85e-11	72.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y780@28890|Euryarchaeota,23P2D@183925|Methanobacteria	183925|Methanobacteria	N	type II secretion	gspF1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
LZS3_k127_7894810_2	420247.Msm_0597	4.704e-79	282.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,23NT6@183925|Methanobacteria	183925|Methanobacteria	U	secretion system protein	gspE	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
LZS3_k127_8001084_0	523850.TON_0123	2.709e-123	409.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,24377@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
LZS3_k127_8001084_3	457405.FSDG_01875	3.416e-07	60.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
LZS3_k127_8001084_2	247490.KSU1_D0311	5.06e-24	116.0	COG0438@1|root,COG0438@2|Bacteria,2IYWS@203682|Planctomycetes	203682|Planctomycetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
LZS3_k127_8001084_1	565033.GACE_1721	1.518e-67	241.0	COG0530@1|root,arCOG02881@2157|Archaea,2XVHN@28890|Euryarchaeota	28890|Euryarchaeota	P	Na Ca antiporter, CaCA family	-	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
LZS3_k127_86631_51	344747.PM8797T_05885	2.582e-16	95.0	COG0726@1|root,COG1864@1|root,COG3209@1|root,COG3210@1|root,COG3386@1|root,COG3391@1|root,COG5276@1|root,COG0726@2|Bacteria,COG1864@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,COG5276@2|Bacteria,2IXF1@203682|Planctomycetes	203682|Planctomycetes	M	Bacterial pre-peptidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC
LZS3_k127_86631_78	1042163.BRLA_c043980	7.958e-05	55.0	COG2247@1|root,COG5295@1|root,COG2247@2|Bacteria,COG5295@2|Bacteria,1UIEY@1239|Firmicutes,4ISK0@91061|Bacilli,27755@186822|Paenibacillaceae	91061|Bacilli	M	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	SLH
LZS3_k127_86631_75	593117.TGAM_0435	1.369e-05	49.0	COG2002@1|root,arCOG00812@2157|Archaea,2Y6IB@28890|Euryarchaeota,244N0@183968|Thermococci	183968|Thermococci	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
LZS3_k127_86631_9	565033.GACE_2221	9.203e-75	262.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
LZS3_k127_86631_14	565033.GACE_2222	3.617e-55	205.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,246QC@183980|Archaeoglobi	183980|Archaeoglobi	J	Forms part of the polypeptide exit tunnel	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
LZS3_k127_86631_53	593117.TGAM_2001	6.719e-16	79.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
LZS3_k127_86631_10	272844.PAB2122	1.625e-72	251.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,242MT@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
LZS3_k127_86631_39	387631.Asulf_00124	6.016e-34	134.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24710@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
LZS3_k127_86631_49	1094980.Mpsy_1141	2.878e-19	96.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,2N9UR@224756|Methanomicrobia	224756|Methanomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
LZS3_k127_86631_18	604354.TSIB_0294	1.707e-46	178.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,243EH@183968|Thermococci	183968|Thermococci	J	Binds the lower part of the 30S subunit head	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
LZS3_k127_86631_72	400682.PAC_15701887	6.058e-06	51.0	COG0255@1|root,KOG3436@2759|Eukaryota,3A1TW@33154|Opisthokonta,3BQFB@33208|Metazoa	33208|Metazoa	J	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RpL35	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02918	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
LZS3_k127_86631_40	339860.Msp_0901	8.731e-33	130.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23PKF@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
LZS3_k127_86631_46	1042877.GQS_04835	4.91e-24	104.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2446S@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
LZS3_k127_86631_26	572546.Arcpr_1351	8.061e-42	157.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,2467B@183980|Archaeoglobi	183980|Archaeoglobi	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
LZS3_k127_86631_47	195522.BD01_2160	5.946e-22	101.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2444Y@183968|Thermococci	183968|Thermococci	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
LZS3_k127_86631_43	351160.RCIX2557	3.296e-31	131.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,2N9HR@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,RS4NT,Ribosomal_S4e,S4
LZS3_k127_86631_19	342949.PNA2_0368	1.821e-45	171.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,242J0@183968|Thermococci	183968|Thermococci	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
LZS3_k127_86631_63	1163730.FFONT_0506	7.493e-10	62.0	COG0199@1|root,arCOG00782@2157|Archaea,2XR7G@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
LZS3_k127_86631_35	420247.Msm_0746	2.056e-35	138.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,23P1I@183925|Methanobacteria	183925|Methanobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
LZS3_k127_86631_30	529709.PYCH_01540	1.397e-38	150.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,243D5@183968|Thermococci	183968|Thermococci	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
LZS3_k127_86631_70	1448860.BBJO01000003_gene2566	2.655e-07	59.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,23SSD@183963|Halobacteria	183963|Halobacteria	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
LZS3_k127_86631_32	419665.Maeo_1402	1.461e-36	143.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23QT2@183939|Methanococci	183939|Methanococci	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
LZS3_k127_86631_21	439481.Aboo_1502	6.332e-45	169.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,3F2QM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
LZS3_k127_86631_17	644281.MFS40622_1746	2.242e-51	191.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,23QAX@183939|Methanococci	183939|Methanococci	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
LZS3_k127_86631_44	573064.Mefer_0675	3.078e-25	110.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,23QSP@183939|Methanococci	183939|Methanococci	J	PFAM ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
LZS3_k127_86631_54	1343739.PAP_01825	1.097e-14	79.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,243K6@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
LZS3_k127_86631_20	1408473.JHXO01000009_gene3349	2.932e-45	169.0	COG2206@1|root,COG2206@2|Bacteria,4PKEV@976|Bacteroidetes,2G3ER@200643|Bacteroidia	976|Bacteroidetes	T	HDIG domain protein	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
LZS3_k127_86631_3	339860.Msp_0885	2.79e-113	379.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,23NV1@183925|Methanobacteria	183925|Methanobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
LZS3_k127_86631_57	647113.Metok_0688	1.165e-13	80.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23QBG@183939|Methanococci	183939|Methanococci	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
LZS3_k127_86631_25	391625.PPSIR1_36492	3.511e-42	177.0	COG4935@1|root,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215,P_proprotein
LZS3_k127_86631_48	859657.RPSI07_1291	2.071e-19	105.0	COG3209@1|root,COG4105@1|root,COG3209@2|Bacteria,COG4105@2|Bacteria,1MVV1@1224|Proteobacteria,2VMJI@28216|Betaproteobacteria,1K0C1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Rhs_assc_core RHS repeat-associated core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PAAR_motif,Peptidase_C39,RHS,RHS_repeat
LZS3_k127_86631_65	103733.JNYO01000003_gene8097	5.106e-09	71.0	COG2152@1|root,COG2152@2|Bacteria,2GN5M@201174|Actinobacteria,4DYHK@85010|Pseudonocardiales	201174|Actinobacteria	G	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
LZS3_k127_86631_36	1267535.KB906767_gene4428	2.594e-35	158.0	COG3240@1|root,COG5263@1|root,COG3240@2|Bacteria,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Big_2,CAP,CW_binding_1,HemolysinCabind,Lipase_GDSL,Mac-1,SLH
LZS3_k127_86631_62	573064.Mefer_0947	2.504e-10	70.0	COG2174@1|root,arCOG04168@2157|Archaea,2Y0IH@28890|Euryarchaeota,23R6M@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
LZS3_k127_86631_59	573063.Metin_0112	4.975e-12	75.0	COG2163@1|root,arCOG04167@2157|Archaea,2XYTF@28890|Euryarchaeota,23R4B@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW
LZS3_k127_86631_61	870187.Thini_4510	1.098e-10	68.0	2C9Y3@1|root,33JDQ@2|Bacteria,1NQEK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_86631_33	1157490.EL26_14885	2.357e-36	141.0	COG1051@1|root,COG1051@2|Bacteria,1UWQJ@1239|Firmicutes,4IFRF@91061|Bacilli,27AGX@186823|Alicyclobacillaceae	91061|Bacilli	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
LZS3_k127_86631_1	572546.Arcpr_1560	5.159e-116	393.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,245T6@183980|Archaeoglobi	183980|Archaeoglobi	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
LZS3_k127_86631_71	935837.JAEK01000011_gene185	3.126e-06	53.0	COG1694@1|root,COG1694@2|Bacteria,1V701@1239|Firmicutes,4HISK@91061|Bacilli,1ZH1U@1386|Bacillus	91061|Bacilli	S	Nucleotide pyrophosphohydrolase	ypjD	-	-	-	-	-	-	-	-	-	-	-	MazG
LZS3_k127_86631_6	673860.AciM339_0863	2.641e-98	340.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,3F2II@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
LZS3_k127_86631_55	693661.Arcve_0434	3.211e-14	82.0	COG1378@1|root,arCOG02037@2157|Archaea,2XXJ9@28890|Euryarchaeota	28890|Euryarchaeota	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
LZS3_k127_86631_29	70601.3257903	1.486e-39	160.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
LZS3_k127_86631_5	444158.MmarC6_0484	9.665e-106	354.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
LZS3_k127_86631_2	387631.Asulf_00738	1.262e-115	384.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
LZS3_k127_86631_16	572546.Arcpr_0478	4.81e-52	197.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,245W2@183980|Archaeoglobi	183980|Archaeoglobi	Q	Conserved hypothetical protein 95	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
LZS3_k127_86631_80	797302.Halru_0888	0.0004508	53.0	COG0517@1|root,arCOG00601@2157|Archaea,2XVRW@28890|Euryarchaeota,23S35@183963|Halobacteria	183963|Halobacteria	S	COG0517 FOG CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
LZS3_k127_86631_58	338966.Ppro_1339	2.571e-13	80.0	COG2510@1|root,COG2510@2|Bacteria,1QV9N@1224|Proteobacteria,43BNU@68525|delta/epsilon subdivisions,2X704@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
LZS3_k127_86631_7	1183377.Py04_1337	1.348e-93	317.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,242ZU@183968|Thermococci	183968|Thermococci	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
LZS3_k127_86631_38	868131.MSWAN_1745	1.424e-34	140.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,23P3J@183925|Methanobacteria	183925|Methanobacteria	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
LZS3_k127_86631_13	224719.Abm4_1367	7.09e-58	213.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,23NSZ@183925|Methanobacteria	183925|Methanobacteria	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
LZS3_k127_86631_56	565033.GACE_1689	6.769e-14	73.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,247AX@183980|Archaeoglobi	183980|Archaeoglobi	L	Centromere kinetochore component CENP-T histone fold	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
LZS3_k127_86631_45	693661.Arcve_1229	2.898e-24	106.0	COG1591@1|root,arCOG00919@2157|Archaea,2XTHF@28890|Euryarchaeota,246ED@183980|Archaeoglobi	183980|Archaeoglobi	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	hjc	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
LZS3_k127_86631_67	3067.XP_002952613.1	1.263e-08	64.0	COG2074@1|root,2QR37@2759|Eukaryota,37JPH@33090|Viridiplantae,34JSZ@3041|Chlorophyta	3041|Chlorophyta	G	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
LZS3_k127_86631_60	411474.COPEUT_02514	8.725e-12	74.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24BUG@186801|Clostridia	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
LZS3_k127_86631_22	1089550.ATTH01000001_gene1584	2.276e-44	165.0	COG3059@1|root,COG3059@2|Bacteria,4NNX8@976|Bacteroidetes,1FK22@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF417,DoxX
LZS3_k127_86631_76	399795.CtesDRAFT_PD2747	2.824e-05	51.0	COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,2VI40@28216|Betaproteobacteria,4ACDP@80864|Comamonadaceae	28216|Betaproteobacteria	U	filamentous haemagglutinin family outer membrane protein	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,PT-VENN
LZS3_k127_86631_50	192952.MM_0545	5.202e-19	90.0	arCOG05148@1|root,arCOG05148@2157|Archaea,2Y5I4@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_86631_68	192952.MM_0546	5.46e-08	55.0	arCOG05149@1|root,arCOG05149@2157|Archaea,2Y4ZG@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_86631_69	304371.MCP_1433	1.14e-07	60.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
LZS3_k127_86631_79	281687.CJA17825b	0.0003447	55.0	KOG0589@1|root,KOG1218@1|root,KOG0589@2759|Eukaryota,KOG1218@2759|Eukaryota,38CP7@33154|Opisthokonta,3BEGK@33208|Metazoa,3D0EW@33213|Bilateria,40R3F@6231|Nematoda,1M1C0@119089|Chromadorea,40T2H@6236|Rhabditida	33208|Metazoa	T	Protein tyrosine kinase	NEK10	GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010562,GO:0010564,GO:0010604,GO:0010646,GO:0010647,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019220,GO:0019222,GO:0019538,GO:0023051,GO:0023056,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031952,GO:0031954,GO:0032268,GO:0032270,GO:0032991,GO:0033674,GO:0036211,GO:0042325,GO:0042327,GO:0043085,GO:0043170,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043549,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051174,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051726,GO:0060255,GO:0061695,GO:0065007,GO:0065009,GO:0070372,GO:0071704,GO:0071900,GO:0071902,GO:0080090,GO:0140096,GO:1901564,GO:1901987,GO:1902494,GO:1902531,GO:1902533,GO:1902749,GO:1902911,GO:1990234	2.7.11.1	ko:K20879	-	-	-	-	ko00000,ko01000,ko01001,ko03400	-	-	-	Pkinase
LZS3_k127_86631_77	7460.GB55781-PA	3.816e-05	58.0	KOG1217@1|root,KOG3594@1|root,KOG1217@2759|Eukaryota,KOG1219@2759|Eukaryota,38BUP@33154|Opisthokonta,3BA2W@33208|Metazoa,3CUNH@33213|Bilateria,41VHE@6656|Arthropoda,3SKFR@50557|Insecta,46JI8@7399|Hymenoptera	33208|Metazoa	T	Low-density lipoprotein receptor domain class A	-	-	-	-	-	-	-	-	-	-	-	-	EGF_3,EGF_CA,NIDO,hEGF
LZS3_k127_86631_73	589924.Ferp_0654	7.52e-06	52.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,246I7@183980|Archaeoglobi	183980|Archaeoglobi	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
LZS3_k127_86631_42	709986.Deima_0355	1.014e-31	139.0	COG1215@1|root,COG1215@2|Bacteria,1WJAN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
LZS3_k127_86631_74	693661.Arcve_0997	9.895e-06	55.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,24732@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, XRE family	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
LZS3_k127_86631_28	596330.HMPREF0628_0427	1.793e-40	155.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,22HHT@1570339|Peptoniphilaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
LZS3_k127_86631_41	1047013.AQSP01000054_gene254	2.12e-32	131.0	COG0756@1|root,COG0756@2|Bacteria,2NPXR@2323|unclassified Bacteria	2|Bacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
LZS3_k127_86631_31	458817.Shal_0856	2.422e-38	151.0	28PNW@1|root,2ZCBD@2|Bacteria,1RIQY@1224|Proteobacteria,1SKNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_86631_66	1280680.AUJU01000024_gene2712	5.351e-09	64.0	COG0406@1|root,COG0406@2|Bacteria,1V3RC@1239|Firmicutes,24GHZ@186801|Clostridia,4BYF3@830|Butyrivibrio	186801|Clostridia	G	Histidine phosphatase superfamily (branch 1)	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
LZS3_k127_86631_23	1459636.NTE_02224	5.025e-44	172.0	COG0640@1|root,arCOG03420@1|root,arCOG01687@2157|Archaea,arCOG03420@2157|Archaea	2157|Archaea	K	PFAM S-layer	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,S_layer_C
LZS3_k127_86631_0	1121918.ARWE01000001_gene2315	1.735e-145	474.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1886	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
LZS3_k127_86631_27	237368.SCABRO_00702	5.937e-41	163.0	COG1208@1|root,COG1208@2|Bacteria,2J0MF@203682|Planctomycetes	203682|Planctomycetes	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,NTP_transferase
LZS3_k127_86631_4	523850.TON_0774	8.168e-113	387.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
LZS3_k127_86631_15	665959.HMPREF1013_04046	1.46e-52	201.0	COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,4HA3W@91061|Bacilli,1ZE0U@1386|Bacillus	91061|Bacilli	C	ATP citrate lyase citrate-binding	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_2,Citrate_bind,Ligase_CoA
LZS3_k127_86631_8	485913.Krac_6705	2.916e-77	269.0	COG0074@1|root,COG0074@2|Bacteria,2G5R4@200795|Chloroflexi	200795|Chloroflexi	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
LZS3_k127_86631_12	204536.SULAZ_1492	7.594e-61	218.0	COG0372@1|root,COG0372@2|Bacteria,2G4GQ@200783|Aquificae	200783|Aquificae	C	Citrate synthase, C-terminal domain	-	-	4.1.3.34	ko:K15234	ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200	M00173	R00354	RC00067,RC00502	ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
LZS3_k127_86631_24	797302.Halru_0159	2.815e-43	168.0	COG0637@1|root,arCOG02293@2157|Archaea,2XTYU@28890|Euryarchaeota,23UQI@183963|Halobacteria	183963|Halobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
LZS3_k127_86631_37	1191523.MROS_0955	1.222e-34	139.0	COG1986@1|root,COG1986@2|Bacteria	2|Bacteria	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
LZS3_k127_86631_34	573064.Mefer_1287	2.488e-36	151.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23QGQ@183939|Methanococci	183939|Methanococci	K	Fibronectin-binding A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
LZS3_k127_86631_11	933801.Ahos_0774	1.201e-67	240.0	COG0144@1|root,arCOG00973@2157|Archaea,2XQ6R@28889|Crenarchaeota	28889|Crenarchaeota	J	NOL1 NOP2 sun family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
LZS3_k127_8705934_6	693661.Arcve_0233	6.608e-66	230.0	COG1100@1|root,arCOG00354@2157|Archaea,2XT36@28890|Euryarchaeota,246VT@183980|Archaeoglobi	183980|Archaeoglobi	S	GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	MMR_HSR1
LZS3_k127_8705934_27	877455.Metbo_0738	3.514e-06	54.0	COG3365@1|root,arCOG04416@2157|Archaea,2XX2F@28890|Euryarchaeota	28890|Euryarchaeota	S	protein conserved in archaea	oapB	-	-	ko:K09743	-	-	-	-	ko00000	-	-	-	DUF2073
LZS3_k127_8705934_16	593750.Metfor_0467	8.822e-19	91.0	COG3364@1|root,arCOG04417@2157|Archaea,2Y0WK@28890|Euryarchaeota,2N9ZI@224756|Methanomicrobia	224756|Methanomicrobia	S	Zn-ribbon containing protein	-	-	-	ko:K07163	-	-	-	-	ko00000	-	-	-	DUF2072
LZS3_k127_8705934_10	1220534.B655_2361	8.012e-38	153.0	COG0084@1|root,arCOG00891@2157|Archaea,2XV9Y@28890|Euryarchaeota,23P0E@183925|Methanobacteria	183925|Methanobacteria	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
LZS3_k127_8705934_4	1151117.AJLF01000004_gene1806	1.524e-80	282.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,243PN@183968|Thermococci	183968|Thermococci	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
LZS3_k127_8705934_13	342949.PNA2_0923	1.485e-22	105.0	COG2129@1|root,arCOG01145@2157|Archaea,2XW7S@28890|Euryarchaeota,242PU@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
LZS3_k127_8705934_17	1265505.ATUG01000003_gene133	1.161e-18	93.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42QSV@68525|delta/epsilon subdivisions,2WMZ5@28221|Deltaproteobacteria,2MI25@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	yrdC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
LZS3_k127_8705934_11	694429.Pyrfu_0001	3.427e-30	138.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPXH@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
LZS3_k127_8705934_9	653733.Selin_0660	1.378e-38	156.0	COG1423@1|root,COG1423@2|Bacteria	2|Bacteria	L	RNA ligase	-	-	-	-	-	-	-	-	-	-	-	-	RNA_ligase
LZS3_k127_8705934_1	593117.TGAM_1718	1.153e-138	461.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,242VY@183968|Thermococci	183968|Thermococci	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
LZS3_k127_8705934_29	1089545.KB913037_gene3161	0.0005026	49.0	COG1522@1|root,COG1522@2|Bacteria,2IMT5@201174|Actinobacteria,4EBN2@85010|Pseudonocardiales	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
LZS3_k127_8705934_2	644281.MFS40622_1035	1.041e-115	383.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
LZS3_k127_8705934_0	573064.Mefer_0037	1.439e-145	476.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
LZS3_k127_8705934_12	573064.Mefer_0147	4.831e-26	112.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,23QYI@183939|Methanococci	183939|Methanococci	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
LZS3_k127_8705934_18	1236689.MMALV_04410	3.683e-13	70.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,3F2VM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
LZS3_k127_8705934_23	406327.Mevan_1428	7.498e-09	62.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,23R5Q@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
LZS3_k127_8705934_22	304371.MCP_2674	1.827e-10	63.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
LZS3_k127_8705934_8	402880.MmarC5_1197	1.261e-51	192.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,23Q1F@183939|Methanococci	183939|Methanococci	K	RNA binding S1 domain protein	-	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
LZS3_k127_8705934_24	529709.PYCH_02040	1.548e-08	62.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
LZS3_k127_8705934_7	1094980.Mpsy_0422	1.641e-65	231.0	COG0034@1|root,COG0367@1|root,COG2102@1|root,arCOG00035@2157|Archaea,arCOG00071@2157|Archaea,arCOG00093@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
LZS3_k127_8705934_15	679926.Mpet_1269	4.97e-20	96.0	COG0518@1|root,arCOG00090@2157|Archaea,2Y5MH@28890|Euryarchaeota	28890|Euryarchaeota	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
LZS3_k127_8705934_25	1265505.ATUG01000002_gene2782	4.959e-08	61.0	COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42T7I@68525|delta/epsilon subdivisions,2WPNZ@28221|Deltaproteobacteria,2MK3Z@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
LZS3_k127_8705934_14	1094980.Mpsy_0729	2.616e-21	112.0	arCOG06531@1|root,arCOG06531@2157|Archaea	1094980.Mpsy_0729|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_8705934_3	187272.Mlg_2396	3.279e-92	347.0	COG4257@1|root,COG4257@2|Bacteria	2|Bacteria	V	antibiotic catabolic process	-	-	-	ko:K13277,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	DUF11,DUF4347,DUF5011,DUF5122,HYR,He_PIG,HemolysinCabind
LZS3_k127_8705934_30	1347368.HG964409_gene7230	0.0006579	55.0	COG4733@1|root,COG4733@2|Bacteria,1UEBB@1239|Firmicutes,4HB9W@91061|Bacilli,1ZEF1@1386|Bacillus	91061|Bacilli	S	Fibronectin type 3 domain	Tnr	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	SLH,fn3
LZS3_k127_8705934_20	264732.Moth_0241	2.69e-11	79.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Calx-beta,DUF11,DUF1573,F5_F8_type_C,FG-GAP,Glyco_hyd_101C,Glyco_hydro_101,NPCBM_assoc,SASA
LZS3_k127_8705934_21	264732.Moth_0242	5.174e-11	73.0	COG5492@1|root,COG5492@2|Bacteria,1VX4D@1239|Firmicutes,252B8@186801|Clostridia	186801|Clostridia	N	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,TIG
LZS3_k127_8705934_28	7955.ENSDARP00000119298	2.913e-05	59.0	KOG1225@1|root,KOG4659@1|root,KOG1225@2759|Eukaryota,KOG4659@2759|Eukaryota,38CNZ@33154|Opisthokonta,3BCCK@33208|Metazoa,3CTIR@33213|Bilateria,4857M@7711|Chordata,48Z3W@7742|Vertebrata,49V8U@7898|Actinopterygii	33208|Metazoa	TW	Teneurin transmembrane protein 2	TENM2	GO:0000003,GO:0000122,GO:0000226,GO:0000902,GO:0000904,GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0001941,GO:0003006,GO:0003008,GO:0003674,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005856,GO:0005886,GO:0005887,GO:0005911,GO:0005938,GO:0006355,GO:0006357,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007017,GO:0007154,GO:0007155,GO:0007156,GO:0007157,GO:0007165,GO:0007267,GO:0007268,GO:0007272,GO:0007274,GO:0007275,GO:0007276,GO:0007399,GO:0007409,GO:0007411,GO:0007413,GO:0007416,GO:0007417,GO:0007420,GO:0007423,GO:0007528,GO:0007548,GO:0007588,GO:0007600,GO:0007601,GO:0008037,GO:0008038,GO:0008039,GO:0008045,GO:0008092,GO:0008150,GO:0008366,GO:0008406,GO:0008584,GO:0008585,GO:0009605,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010001,GO:0010171,GO:0010172,GO:0010256,GO:0010468,GO:0010470,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010720,GO:0010927,GO:0010975,GO:0010976,GO:0012505,GO:0014003,GO:0014013,GO:0014015,GO:0016020,GO:0016021,GO:0016043,GO:0016200,GO:0016358,GO:0016477,GO:0016604,GO:0016605,GO:0019219,GO:0019222,GO:0019722,GO:0019932,GO:0019953,GO:0021782,GO:0022008,GO:0022010,GO:0022407,GO:0022409,GO:0022414,GO:0022416,GO:0022603,GO:0022607,GO:0022610,GO:0023052,GO:0030030,GO:0030054,GO:0030154,GO:0030155,GO:0030175,GO:0030182,GO:0030198,GO:0030421,GO:0030424,GO:0030425,GO:0030426,GO:0030427,GO:0030863,GO:0031005,GO:0031012,GO:0031122,GO:0031175,GO:0031224,GO:0031226,GO:0031290,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031344,GO:0031346,GO:0031594,GO:0031641,GO:0031643,GO:0031644,GO:0031646,GO:0031974,GO:0031981,GO:0032288,GO:0032289,GO:0032291,GO:0032501,GO:0032502,GO:0032504,GO:0032989,GO:0032990,GO:0033267,GO:0034110,GO:0034114,GO:0034116,GO:0035295,GO:0035556,GO:0035584,GO:0036477,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0040019,GO:0040032,GO:0040039,GO:0042051,GO:0042063,GO:0042221,GO:0042330,GO:0042461,GO:0042462,GO:0042552,GO:0042734,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043025,GO:0043062,GO:0043197,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043954,GO:0044057,GO:0044085,GO:0044087,GO:0044089,GO:0044297,GO:0044309,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044448,GO:0044451,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0045137,GO:0045202,GO:0045211,GO:0045466,GO:0045467,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045685,GO:0045687,GO:0045785,GO:0045892,GO:0045934,GO:0045995,GO:0046530,GO:0046545,GO:0046546,GO:0046660,GO:0046661,GO:0046982,GO:0046983,GO:0048036,GO:0048058,GO:0048468,GO:0048499,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048563,GO:0048565,GO:0048569,GO:0048589,GO:0048592,GO:0048598,GO:0048608,GO:0048609,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048709,GO:0048713,GO:0048714,GO:0048731,GO:0048749,GO:0048786,GO:0048788,GO:0048790,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0050803,GO:0050807,GO:0050808,GO:0050839,GO:0050877,GO:0050896,GO:0050918,GO:0050953,GO:0051094,GO:0051124,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051179,GO:0051239,GO:0051240,GO:0051252,GO:0051253,GO:0051489,GO:0051491,GO:0051674,GO:0051704,GO:0051716,GO:0051960,GO:0051962,GO:0055123,GO:0060255,GO:0060284,GO:0060322,GO:0060465,GO:0060491,GO:0061024,GO:0061458,GO:0061564,GO:0065007,GO:0065008,GO:0070013,GO:0070831,GO:0070983,GO:0071711,GO:0071840,GO:0071944,GO:0080090,GO:0090596,GO:0097060,GO:0097090,GO:0097435,GO:0097447,GO:0097458,GO:0097485,GO:0098590,GO:0098609,GO:0098742,GO:0098793,GO:0098794,GO:0098831,GO:0098858,GO:0098916,GO:0099173,GO:0099174,GO:0099536,GO:0099537,GO:0099558,GO:0099568,GO:0099569,GO:0099738,GO:0106030,GO:0120025,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0150034,GO:1902679,GO:1903385,GO:1903506,GO:1903507,GO:1990709,GO:2000026,GO:2000112,GO:2000113,GO:2000331,GO:2000543,GO:2001141,GO:2001197	-	-	-	-	-	-	-	-	-	-	EGF_2,RHS_repeat,Ten_N,Tox-GHH
LZS3_k127_8705934_26	391625.PPSIR1_40859	3.619e-07	66.0	2DSD6@1|root,33FM0@2|Bacteria,1PBXM@1224|Proteobacteria,43862@68525|delta/epsilon subdivisions,2X3FW@28221|Deltaproteobacteria,2YVX7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_8705934_5	448385.sce4949	1.04e-67	266.0	COG0402@1|root,COG1506@1|root,COG5184@1|root,COG0402@2|Bacteria,COG1506@2|Bacteria,COG5184@2|Bacteria,1QX7B@1224|Proteobacteria,431GN@68525|delta/epsilon subdivisions,2WWHZ@28221|Deltaproteobacteria,2YWHU@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF4215)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215
LZS3_k127_8705934_19	304371.MCP_2802	2.452e-11	79.0	COG1404@1|root,arCOG06738@1|root,arCOG00702@2157|Archaea,arCOG06738@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
LZS3_k127_8739693_17	565033.GACE_1479	1.999e-22	109.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2468R@183980|Archaeoglobi	183980|Archaeoglobi	K	segregation and condensation protein B	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
LZS3_k127_8739693_19	411470.RUMGNA_03196	1.739e-19	99.0	COG1073@1|root,COG1073@2|Bacteria,1UXYN@1239|Firmicutes,24DU6@186801|Clostridia	186801|Clostridia	E	Alpha beta	aroD	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
LZS3_k127_8739693_6	868131.MSWAN_0705	8.548e-61	222.0	arCOG10178@1|root,arCOG10178@2157|Archaea,2XY0I@28890|Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
LZS3_k127_8739693_0	1094980.Mpsy_2852	2.426e-296	931.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
LZS3_k127_8739693_23	573063.Metin_1148	2.323e-11	77.0	COG0550@1|root,COG0551@1|root,COG1372@1|root,arCOG03146@1|root,arCOG01527@2157|Archaea,arCOG03146@2157|Archaea,arCOG03158@2157|Archaea,arCOG05045@2157|Archaea,2XU6T@28890|Euryarchaeota,23QA8@183939|Methanococci	183939|Methanococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,Topoisom_bac,Toprim,zf-C4_Topoisom
LZS3_k127_8739693_5	192952.MM_1491	1.184e-80	291.0	COG0433@1|root,arCOG00284@2157|Archaea,2Y7NC@28890|Euryarchaeota,2NBKJ@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
LZS3_k127_8739693_22	1123372.AUIT01000001_gene806	6.302e-12	77.0	COG2199@1|root,COG2905@1|root,COG2905@2|Bacteria,COG3706@2|Bacteria,2GHH1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GGDEF,PAS_9
LZS3_k127_8739693_3	1455608.JDTH01000006_gene2641	9.521e-92	315.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,23TJF@183963|Halobacteria	183963|Halobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1b
LZS3_k127_8739693_25	351160.RCIX1020	6.376e-08	64.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
LZS3_k127_8739693_12	304371.MCP_0471	8.251e-32	134.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
LZS3_k127_8739693_29	697329.Rumal_1816	0.0009392	49.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
LZS3_k127_8739693_24	626887.J057_02460	2.404e-11	70.0	COG1226@1|root,COG1226@2|Bacteria,1NH49@1224|Proteobacteria,1SHAW@1236|Gammaproteobacteria,46952@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,PDZ_2
LZS3_k127_8739693_21	469378.Ccur_14080	4.818e-13	70.0	COG0550@1|root,COG0550@2|Bacteria,2HVAJ@201174|Actinobacteria,4CWJS@84998|Coriobacteriia	84998|Coriobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_8739693_20	333138.LQ50_09605	2.989e-18	89.0	COG2337@1|root,COG2337@2|Bacteria,1V6CM@1239|Firmicutes,4HXXC@91061|Bacilli,1ZJRQ@1386|Bacillus	91061|Bacilli	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PemK_toxin
LZS3_k127_8739693_27	1094980.Mpsy_0247	3.476e-06	55.0	arCOG11378@1|root,arCOG11378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_8739693_11	694429.Pyrfu_1972	4.542e-33	136.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
LZS3_k127_8739693_7	593117.TGAM_1968	1.089e-48	185.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,242UM@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
LZS3_k127_8739693_8	572546.Arcpr_1027	2.126e-46	173.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,24666@183980|Archaeoglobi	183980|Archaeoglobi	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
LZS3_k127_8739693_10	1220534.B655_1477	2.714e-35	144.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,23NZ9@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
LZS3_k127_8739693_18	273063.STK_20660	8.498e-22	99.0	COG1727@1|root,arCOG00780@2157|Archaea,2XQV1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
LZS3_k127_8739693_16	523850.TON_0107	1.536e-22	102.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
LZS3_k127_8739693_15	679926.Mpet_0754	3.578e-25	109.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2N9S9@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
LZS3_k127_8739693_28	667015.Bacsa_1199	7.818e-05	50.0	COG1848@1|root,COG1848@2|Bacteria,4NNGQ@976|Bacteroidetes,2FUUE@200643|Bacteroidia,4AUZ9@815|Bacteroidaceae	976|Bacteroidetes	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_3
LZS3_k127_8739693_26	315730.BcerKBAB4_5611	8.307e-07	55.0	COG0640@1|root,COG0640@2|Bacteria,1V6Z2@1239|Firmicutes,4HKFB@91061|Bacilli,1ZI30@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
LZS3_k127_8739693_1	1321779.HMPREF1984_00956	1.297e-175	562.0	COG0719@1|root,COG0719@2|Bacteria,378VG@32066|Fusobacteria	32066|Fusobacteria	O	feS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
LZS3_k127_8739693_9	1227484.C471_10795	2.188e-36	151.0	COG0719@1|root,arCOG01715@2157|Archaea,2XU1H@28890|Euryarchaeota,23SSI@183963|Halobacteria	183963|Halobacteria	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB2	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
LZS3_k127_8739693_2	562970.Btus_0575	8.527e-110	368.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,27802@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
LZS3_k127_8739693_13	926550.CLDAP_20380	2.894e-30	124.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi	200795|Chloroflexi	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
LZS3_k127_8739693_4	36874.HQ34_03960	2.961e-89	299.0	COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,2FMCD@200643|Bacteroidia,22WQ0@171551|Porphyromonadaceae	976|Bacteroidetes	O	Part of SUF system involved in inserting iron-sulfur clusters into proteins	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
LZS3_k127_980737_46	285535.JOEY01000002_gene5027	3.653e-13	74.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	mprA	-	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
LZS3_k127_980737_17	439481.Aboo_0092	1.14e-54	201.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,3F38Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Phage integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
LZS3_k127_980737_58	436308.Nmar_0505	2.317e-06	53.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
LZS3_k127_980737_38	1173027.Mic7113_0312	1.107e-19	95.0	COG0703@1|root,COG0703@2|Bacteria	2|Bacteria	F	shikimate kinase activity	cas2	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	6PF2K,AAA_33,His_Phos_1,SKI
LZS3_k127_980737_13	1159488.SEQMU2_05950	1.309e-82	280.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,4GY8S@90964|Staphylococcaceae	91061|Bacilli	C	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
LZS3_k127_980737_14	523850.TON_0847	6.337e-81	273.0	COG1225@1|root,arCOG00310@2157|Archaea,2XWQE@28890|Euryarchaeota	28890|Euryarchaeota	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp1	-	1.11.1.15	ko:K03386,ko:K03564	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
LZS3_k127_980737_16	1047013.AQSP01000139_gene2393	7.115e-61	214.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
LZS3_k127_980737_10	1047013.AQSP01000139_gene2394	2.267e-90	306.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
LZS3_k127_980737_59	633148.Tagg_0521	5.65e-06	54.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
LZS3_k127_980737_25	330214.NIDE1591	2.854e-41	163.0	COG3359@1|root,COG3359@2|Bacteria,3J137@40117|Nitrospirae	40117|Nitrospirae	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
LZS3_k127_980737_44	368407.Memar_1961	7.958e-15	78.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,2N9X1@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
LZS3_k127_980737_20	1220534.B655_2053	4.655e-51	188.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,23PJS@183925|Methanobacteria	183925|Methanobacteria	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
LZS3_k127_980737_18	565033.GACE_0021	4.62e-52	191.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,246VI@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
LZS3_k127_980737_43	634498.mru_0400	7.478e-15	80.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,23P8C@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
LZS3_k127_980737_29	1183377.Py04_1258	8.618e-37	146.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,242ZB@183968|Thermococci	183968|Thermococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
LZS3_k127_980737_22	1220534.B655_0245	1.91e-48	182.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23NZG@183925|Methanobacteria	183925|Methanobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
LZS3_k127_980737_32	647113.Metok_0541	1.924e-30	129.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,23QVR@183939|Methanococci	183939|Methanococci	K	Transcription elongation factor Spt5	spt5	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
LZS3_k127_980737_52	523845.AQXV01000054_gene1607	1.897e-09	60.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y0DZ@28890|Euryarchaeota,23R9W@183939|Methanococci	183939|Methanococci	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
LZS3_k127_980737_5	69014.TK1421	5.83e-135	440.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,242PW@183968|Thermococci	183968|Thermococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
LZS3_k127_980737_26	877455.Metbo_0375	2.463e-40	157.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,23NZB@183925|Methanobacteria	183925|Methanobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
LZS3_k127_980737_34	397291.C804_00108	2.084e-25	114.0	COG1102@1|root,COG1102@2|Bacteria,1VW7Q@1239|Firmicutes,24Q3U@186801|Clostridia,27REN@186928|unclassified Lachnospiraceae	186801|Clostridia	F	Cytidylate kinase	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
LZS3_k127_980737_2	224325.AF_1451	1.515e-202	645.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,246XE@183980|Archaeoglobi	183980|Archaeoglobi	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
LZS3_k127_980737_39	768679.TTX_1708	3.76e-19	101.0	COG1078@1|root,arCOG04430@2157|Archaea,2XQYA@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART metal-dependent phosphohydrolase, HD region	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
LZS3_k127_980737_56	1448860.BBJO01000019_gene1844	3.057e-08	58.0	arCOG02989@1|root,arCOG02989@2157|Archaea,2Y00B@28890|Euryarchaeota,23XHN@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LZS3_k127_980737_7	877455.Metbo_0823	1.361e-127	427.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,23NRJ@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
LZS3_k127_980737_30	1121441.AUCX01000029_gene1617	1.144e-36	145.0	COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WQRN@28221|Deltaproteobacteria,2MBWX@213115|Desulfovibrionales	28221|Deltaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
LZS3_k127_980737_48	718252.FP2_07790	7.5e-11	73.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,3WHYS@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
LZS3_k127_980737_60	1500281.JQKZ01000005_gene4007	0.0001529	54.0	COG0464@1|root,COG0464@2|Bacteria,4NFWG@976|Bacteroidetes,1HZA4@117743|Flavobacteriia,3ZQF8@59732|Chryseobacterium	976|Bacteroidetes	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
LZS3_k127_980737_28	69014.TK1933	3.53e-38	153.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,24393@183968|Thermococci	183968|Thermococci	J	Conserved hypothetical protein 95	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
LZS3_k127_980737_57	386456.JQKN01000016_gene928	3.489e-08	61.0	COG1695@1|root,arCOG00001@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
LZS3_k127_980737_19	342949.PNA2_0424	3.402e-51	192.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,242ZK@183968|Thermococci	183968|Thermococci	J	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
LZS3_k127_980737_41	186497.PF1872	1.38e-16	82.0	COG2451@1|root,arCOG04304@2157|Archaea,2Y0KT@28890|Euryarchaeota,244KT@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL33 family	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
LZS3_k127_980737_31	1042877.GQS_01135	3.044e-33	132.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,244EN@183968|Thermococci	183968|Thermococci	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
LZS3_k127_980737_4	523845.AQXV01000054_gene1669	3.978e-178	567.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,23Q4E@183939|Methanococci	183939|Methanococci	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
LZS3_k127_980737_9	243232.MJ_0622	2.529e-112	372.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
LZS3_k127_980737_1	647113.Metok_0480	3.948e-261	822.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,23Q1Z@183939|Methanococci	183939|Methanococci	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
LZS3_k127_980737_23	70601.3257106	5.815e-43	162.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,243PX@183968|Thermococci	183968|Thermococci	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
LZS3_k127_980737_45	797210.Halxa_0715	1.34e-14	76.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,23XGF@183963|Halobacteria	183963|Halobacteria	J	binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
LZS3_k127_980737_40	523845.AQXV01000055_gene45	6.259e-19	88.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,23R3Y@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
LZS3_k127_980737_36	868131.MSWAN_1751	7.601e-24	104.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,23P3I@183925|Methanobacteria	183925|Methanobacteria	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
LZS3_k127_980737_54	1313301.AUGC01000005_gene264	6.378e-09	60.0	COG1141@1|root,COG1141@2|Bacteria,4NSRI@976|Bacteroidetes	976|Bacteroidetes	C	4Fe-4S ferredoxin	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
LZS3_k127_980737_37	411469.EUBHAL_02314	5.621e-20	102.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,25WUY@186806|Eubacteriaceae	186801|Clostridia	FG	Psort location Cytoplasmic, score	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
LZS3_k127_980737_55	411469.EUBHAL_02314	7.271e-09	63.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,25WUY@186806|Eubacteriaceae	186801|Clostridia	FG	Psort location Cytoplasmic, score	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
LZS3_k127_980737_35	580340.Tlie_0607	5.26e-24	114.0	COG0568@1|root,COG0568@2|Bacteria,3TACS@508458|Synergistetes	508458|Synergistetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
LZS3_k127_980737_53	573064.Mefer_1204	5.926e-09	66.0	COG1989@1|root,arCOG02298@2157|Archaea,2Y64R@28890|Euryarchaeota,23QES@183939|Methanococci	183939|Methanococci	N	Peptidase A24A, prepilin type IV	flaK	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
LZS3_k127_980737_33	1123277.KB893202_gene6218	8.273e-26	115.0	COG0637@1|root,COG0637@2|Bacteria,4NHHK@976|Bacteroidetes,47P9C@768503|Cytophagia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
LZS3_k127_980737_6	523841.HFX_2882	1.418e-128	431.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,23SRU@183963|Halobacteria	183963|Halobacteria	K	histone acetyltransferase, ELP3 family	elp3	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
LZS3_k127_980737_11	572546.Arcpr_0582	5.012e-86	295.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,2462S@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	-	ko:K22446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
LZS3_k127_980737_42	1391647.AVSV01000002_gene1294	3.787e-15	85.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
LZS3_k127_980737_21	263820.PTO0853	9.391e-49	177.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,241NK@183967|Thermoplasmata	183967|Thermoplasmata	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
LZS3_k127_980737_50	666510.ASAC_1179	6.467e-10	66.0	COG0195@1|root,arCOG01760@2157|Archaea,2XQDA@28889|Crenarchaeota	28889|Crenarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2,KH_5
LZS3_k127_980737_51	589924.Ferp_0759	1.683e-09	61.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,246FC@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
LZS3_k127_980737_12	399549.Msed_0035	5.545e-84	292.0	COG0086@1|root,arCOG04256@2157|Archaea,2XPSD@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
LZS3_k127_980737_0	1094980.Mpsy_1008	2.33e-266	845.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
LZS3_k127_980737_3	420247.Msm_0910	1.226e-196	629.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,23NMQ@183925|Methanobacteria	183925|Methanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB1	-	2.7.7.6	ko:K03044,ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
LZS3_k127_980737_8	1343739.PAP_02710	6.828e-127	423.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,24327@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
LZS3_k127_980737_47	456320.Mvol_1030	9.492e-13	74.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,23RAF@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
LZS3_k127_980737_27	410359.Pcal_0608	7.075e-40	156.0	COG0035@1|root,arCOG04128@2157|Archaea,2XQ7W@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
LZS3_k127_980737_24	96561.Dole_0052	1.03e-41	161.0	COG3647@1|root,COG3647@2|Bacteria,1RGJN@1224|Proteobacteria	1224|Proteobacteria	S	Membrane	-	-	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
LZS3_k127_980737_15	386456.JQKN01000008_gene1391	1.355e-80	294.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
LZS3_k127_980737_49	1123360.thalar_02087	1.042e-10	70.0	COG4104@1|root,COG4104@2|Bacteria,1N0ZK@1224|Proteobacteria,2UGZY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PAAR motif	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
LZS3_k127_980737_61	744872.Spica_1252	0.0003668	48.0	COG2426@1|root,COG2426@2|Bacteria,2J7NY@203691|Spirochaetes	203691|Spirochaetes	S	small multi-drug export	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
## 847 queries scanned
## Total time (seconds): 29.824626922607422
## Rate: 28.40 q/s