## Mon Nov 11 17:27:30 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/M/MMD1_bin.17.fa -m mmseqs --itype genome -o MMD1_bin.17 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/MMD1_bin.17 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMD1_k127_1013219_1	795797.C497_14317	7.271e-17	88.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,23W4Z@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1013219_0	868131.MSWAN_1950	1.21e-103	356.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
MMD1_k127_1013219_2	572478.Vdis_1727	8.885e-07	59.0	COG0727@1|root,arCOG02584@2157|Archaea,2XR8T@28889|Crenarchaeota	28889|Crenarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMD1_k127_1013400_3	439481.Aboo_0215	6.652e-13	74.0	COG1719@1|root,arCOG01688@2157|Archaea	2157|Archaea	K	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	DUF2507,V4R
MMD1_k127_1013400_2	673860.AciM339_0604	1.547e-42	164.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4UK@28890|Euryarchaeota,3F2ZZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	GvpD gas vesicle protein	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_1013400_4	1104324.P186_2731	0.0001742	47.0	COG3609@1|root,arCOG01009@2157|Archaea	2157|Archaea	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
MMD1_k127_1013400_1	673860.AciM339_1466	2.709e-54	198.0	COG0284@1|root,arCOG00081@2157|Archaea,2XU66@28890|Euryarchaeota,3F2M4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0060	OMPdecase
MMD1_k127_1013400_0	1089551.KE386572_gene1743	2.432e-159	549.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_1029572_0	1232410.KI421412_gene323	2.967e-90	317.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMD1_k127_1029572_1	521011.Mpal_1042	1.266e-47	188.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
MMD1_k127_1029572_2	673860.AciM339_1211	2.332e-37	151.0	COG1361@1|root,arCOG02079@2157|Archaea,2Y6ZQ@28890|Euryarchaeota,3F30V@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1032406_0	1089551.KE386572_gene1743	2.054e-22	113.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_105816_1	439481.Aboo_0098	3.952e-44	166.0	COG1591@1|root,arCOG00919@2157|Archaea,2XY2Q@28890|Euryarchaeota,3F2NJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Archaeal holliday junction resolvase (hjc)	-	-	-	-	-	-	-	-	-	-	-	-	Hjc
MMD1_k127_105816_2	673860.AciM339_0285	6.776e-26	120.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMD1_k127_105816_3	1437606.BBOH_0331	1.422e-05	57.0	COG0071@1|root,COG0071@2|Bacteria,2HZHR@201174|Actinobacteria,4D0H9@85004|Bifidobacteriales	201174|Actinobacteria	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMD1_k127_105816_0	868864.Dester_1078	1.706e-44	172.0	COG1620@1|root,COG1620@2|Bacteria	2|Bacteria	C	l-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
MMD1_k127_1077540_11	760568.Desku_1478	1.669e-39	170.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
MMD1_k127_1077540_1	760568.Desku_1499	1.299e-219	693.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,264B9@186807|Peptococcaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4,1.3.99.33	ko:K00239,ko:K00244,ko:K17363	ko00020,ko00190,ko00340,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00340,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164,R10330	RC00045,RC00669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind,FMN_red
MMD1_k127_1077540_5	760568.Desku_1500	1.068e-89	302.0	COG1152@1|root,COG1152@2|Bacteria,1UKJG@1239|Firmicutes,25FYP@186801|Clostridia,26446@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_10,Fer4_9
MMD1_k127_1077540_9	1125863.JAFN01000001_gene1776	1.286e-66	241.0	COG1150@1|root,COG1150@2|Bacteria,1R1YD@1224|Proteobacteria,43DCI@68525|delta/epsilon subdivisions,2X8II@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1077540_10	429009.Adeg_2015	1.401e-49	201.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
MMD1_k127_1077540_0	316067.Geob_3723	1.347e-230	734.0	COG1148@1|root,COG1148@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
MMD1_k127_1077540_8	765912.Thimo_0248	2.104e-82	284.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_1077540_12	765912.Thimo_0247	3.106e-34	140.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390,ko:K16887	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD1_k127_1077540_13	292459.STH2879	1.991e-18	93.0	COG2268@1|root,COG2268@2|Bacteria,1TQDT@1239|Firmicutes,247MK@186801|Clostridia	186801|Clostridia	S	SPFH Band 7 PHB domain protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
MMD1_k127_1077540_3	439481.Aboo_0845	3.298e-115	383.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,3F31T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	iAF692.Mbar_A0472	ABC_tran,oligo_HPY
MMD1_k127_1077540_2	439481.Aboo_0844	2.356e-118	391.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota,3F39K@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMD1_k127_1077540_7	673860.AciM339_0162	2.807e-85	317.0	COG1173@1|root,arCOG00748@2157|Archaea,2XVZA@28890|Euryarchaeota,3F300@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMD1_k127_1077540_6	673860.AciM339_0163	1.612e-86	296.0	COG0601@1|root,arCOG00751@2157|Archaea,2XV9R@28890|Euryarchaeota,3F3A2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMD1_k127_1077540_4	439481.Aboo_0794	4.054e-92	344.0	COG0747@1|root,arCOG00385@1|root,arCOG02488@1|root,arCOG00385@2157|Archaea,arCOG01534@2157|Archaea,arCOG02488@2157|Archaea,2XU4K@28890|Euryarchaeota,3F35E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMD1_k127_1081905_0	439481.Aboo_0635	2.31e-83	293.0	COG0112@1|root,arCOG00070@2157|Archaea,2XX80@28890|Euryarchaeota,3F334@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Serine hydroxymethyltransferase	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMD1_k127_109444_1	1457250.BBMO01000001_gene1581	1.567e-88	334.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_109444_0	673860.AciM339_0865	6.873e-93	312.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,3F2G0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMD1_k127_109444_2	439481.Aboo_0184	7.924e-80	273.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,3F2JN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
MMD1_k127_1113490_3	479433.Caci_6029	3.925e-06	57.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria	201174|Actinobacteria	S	Modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD1_k127_1113490_0	439481.Aboo_0294	2.116e-67	241.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,3F2P4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMD1_k127_1113490_1	673860.AciM339_0944	1.078e-21	102.0	arCOG00743@1|root,arCOG00743@2157|Archaea,2Y3FU@28890|Euryarchaeota,3F3AW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1113490_2	673860.AciM339_0945	2.489e-15	79.0	arCOG04079@1|root,arCOG04079@2157|Archaea,2Y184@28890|Euryarchaeota,3F3HW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1122650_0	1123252.ATZF01000027_gene1612	4.525e-50	197.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_1126579_1	323259.Mhun_0504	7.817e-51	187.0	COG3382@1|root,arCOG04250@2157|Archaea	2157|Archaea	S	PFAM B3 4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
MMD1_k127_1126579_4	1124982.MSI_00150	5.73e-25	108.0	COG0853@1|root,COG0853@2|Bacteria,2J7Z4@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
MMD1_k127_1126579_2	589924.Ferp_0541	1.097e-40	166.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD1_k127_1126579_3	1114856.C496_18313	5.841e-28	121.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMD1_k127_1126579_0	941824.TCEL_01674	1.038e-194	617.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,36DK8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMD1_k127_1136008_9	1094980.Mpsy_2214	7.608e-09	70.0	arCOG03256@1|root,arCOG03256@2157|Archaea,2Y1RB@28890|Euryarchaeota	28890|Euryarchaeota	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
MMD1_k127_1136008_6	797209.ZOD2009_17860	2.508e-15	85.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,23W8H@183963|Halobacteria	183963|Halobacteria	S	KEOPS complex Cgi121-like subunit	cgi121	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
MMD1_k127_1136008_0	1041930.Mtc_2490	2.244e-191	623.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMD1_k127_1136008_2	679926.Mpet_2551	1.836e-63	223.0	arCOG10446@1|root,arCOG10446@2157|Archaea,2Y1MQ@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
MMD1_k127_1136008_3	368407.Memar_2263	4.01e-39	153.0	arCOG09456@1|root,arCOG09456@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1136008_11	1444310.JANV01000048_gene2149	9.461e-07	61.0	2BRCM@1|root,32KBA@2|Bacteria,1TVE3@1239|Firmicutes,4I9K6@91061|Bacilli,1ZJY4@1386|Bacillus	91061|Bacilli	S	DNA-sulfur modification-associated	-	-	-	-	-	-	-	-	-	-	-	-	DndB
MMD1_k127_1136008_5	518766.Rmar_2866	1.153e-20	99.0	COG1708@1|root,COG1708@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD1_k127_1136008_12	593750.Metfor_1423	2.669e-06	56.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y05T@28890|Euryarchaeota	28890|Euryarchaeota	S	HEPN domain	-	-	-	ko:K09132	-	-	-	-	ko00000	-	-	-	HEPN
MMD1_k127_1136008_8	756067.MicvaDRAFT_1858	2.257e-10	72.0	COG1708@1|root,COG1708@2|Bacteria,1G7S7@1117|Cyanobacteria,1HI7R@1150|Oscillatoriales	1117|Cyanobacteria	L	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
MMD1_k127_1136008_7	1042877.GQS_07885	3.522e-13	74.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y05T@28890|Euryarchaeota,244GD@183968|Thermococci	183968|Thermococci	S	HEPN domain	-	-	-	ko:K09132	-	-	-	-	ko00000	-	-	-	HEPN
MMD1_k127_1136008_1	105425.BBPL01000003_gene6967	7.734e-87	298.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,2NFU5@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD1_k127_1136008_4	234267.Acid_5435	3.84e-22	108.0	COG4149@1|root,COG4149@2|Bacteria,3Y4EA@57723|Acidobacteria	57723|Acidobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
MMD1_k127_1136008_10	1185766.DL1_04255	2.624e-07	57.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,2XP2D@285107|Thioclava	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	glxR	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
MMD1_k127_1166435_3	1094980.Mpsy_1570	0.0004845	45.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
MMD1_k127_1166435_0	760568.Desku_2121	3.413e-95	329.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,2609U@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
MMD1_k127_1166435_1	1123288.SOV_4c05150	2.662e-29	137.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,4H43Q@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_5
MMD1_k127_1166435_2	644282.Deba_2526	1.085e-12	81.0	COG1520@1|root,COG1520@2|Bacteria,1NSSR@1224|Proteobacteria,42YDJ@68525|delta/epsilon subdivisions,2WU3N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1175340_0	547144.HydHO_0636	2.114e-43	163.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
MMD1_k127_1175340_1	1120954.ATXE01000003_gene303	3.038e-27	130.0	COG1409@1|root,COG3291@1|root,COG1409@2|Bacteria,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales	201174|Actinobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
MMD1_k127_1175340_2	926550.CLDAP_28350	1.251e-18	91.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
MMD1_k127_1177002_1	931277.C448_14303	7.827e-48	182.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,23UTP@183963|Halobacteria	183963|Halobacteria	J	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMD1_k127_1177002_0	673860.AciM339_1547	6.172e-244	770.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,3F2HW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
MMD1_k127_1177002_3	415426.Hbut_1560	2.83e-37	161.0	COG1056@1|root,arCOG00972@2157|Archaea,2XQI1@28889|Crenarchaeota	28889|Crenarchaeota	F	nicotinamide-nucleotide adenylyltransferase	nadM	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMD1_k127_1177002_4	292.DM42_5853	6.133e-23	116.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VNQS@28216|Betaproteobacteria,1K4ZC@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3,HemolysinCabind
MMD1_k127_1177002_2	419610.Mext_3560	9.408e-48	185.0	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,2TW46@28211|Alphaproteobacteria,1JUBR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMD1_k127_1177192_2	1121405.dsmv_2611	9.533e-10	63.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
MMD1_k127_1177192_1	1121904.ARBP01000003_gene6366	1.643e-145	487.0	COG3367@1|root,COG3367@2|Bacteria,4NGXN@976|Bacteroidetes,47NP1@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
MMD1_k127_1177192_0	1121405.dsmv_2608	5.229e-153	492.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
MMD1_k127_1205800_0	1379698.RBG1_1C00001G0991	2.598e-31	143.0	COG2911@1|root,COG2931@1|root,COG4447@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4447@2|Bacteria,2NR5X@2323|unclassified Bacteria	2|Bacteria	Q	FlgD Ig-like domain	-	-	3.2.1.136	ko:K15924	-	-	-	-	ko00000,ko01000	-	GH5	-	CBM_3,DUF1735,Laminin_G_3
MMD1_k127_1209955_0	910964.GEAM_2371	8.777e-09	66.0	COG2911@1|root,COG4932@1|root,COG2911@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	PFAM FecR protein	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
MMD1_k127_1209955_1	266940.Krad_3761	0.0002299	54.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria	201174|Actinobacteria	M	Oxidoreductase molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
MMD1_k127_1214962_5	1269813.ATUL01000027_gene2670	1.762e-10	68.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMD1_k127_1214962_0	589924.Ferp_1446	9.018e-117	395.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,245SX@183980|Archaeoglobi	183980|Archaeoglobi	E	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMD1_k127_1214962_1	439481.Aboo_1449	1.301e-66	237.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,3F2RN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMD1_k127_1214962_3	351160.RCIX2461	1.348e-25	111.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,2NB7P@224756|Methanomicrobia	224756|Methanomicrobia	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMD1_k127_1214962_6	439481.Aboo_0460	6.468e-05	51.0	COG1522@1|root,arCOG01117@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,CBS
MMD1_k127_1214962_4	635013.TherJR_1245	1.576e-16	85.0	COG2768@1|root,COG2768@2|Bacteria,1UJ45@1239|Firmicutes,24W31@186801|Clostridia,2668A@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMD1_k127_1214962_2	264732.Moth_2065	3.497e-32	145.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes	1239|Firmicutes	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
MMD1_k127_1230463_0	673860.AciM339_0595	7.525e-95	323.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,3F2JJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Belongs to the peptidase M24B family	pepQ1	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMD1_k127_1230463_1	673860.AciM339_0377	4.765e-35	140.0	COG0720@1|root,arCOG02172@2157|Archaea,2XXFY@28890|Euryarchaeota,3F2RI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMD1_k127_1230902_1	644281.MFS40622_0209	3.004e-262	824.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD1_k127_1230902_8	1236689.MMALV_13670	1.443e-29	126.0	COG2048@1|root,arCOG00964@2157|Archaea,2XZ7E@28890|Euryarchaeota,3F2WA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD1_k127_1230902_5	456320.Mvol_0794	5.323e-83	288.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_1230902_6	429009.Adeg_2015	7.48e-51	198.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
MMD1_k127_1230902_0	429009.Adeg_1885	0.0	1047.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
MMD1_k127_1230902_4	335543.Sfum_0013	5.883e-102	352.0	COG0247@1|root,COG1908@1|root,COG0247@2|Bacteria,COG1908@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Fer4_9,FlpD
MMD1_k127_1230902_3	419665.Maeo_0095	6.635e-134	453.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD1_k127_1230902_2	335543.Sfum_1179	3.119e-166	546.0	COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
MMD1_k127_1230902_7	880072.Desac_0835	4.498e-47	179.0	COG1908@1|root,COG2512@1|root,COG1908@2|Bacteria,COG2512@2|Bacteria,1RCZY@1224|Proteobacteria,42TFE@68525|delta/epsilon subdivisions,2WPDR@28221|Deltaproteobacteria,2MRBM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
MMD1_k127_1234715_3	1122939.ATUD01000019_gene1534	8.426e-09	66.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4CPKT@84995|Rubrobacteria	84995|Rubrobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMD1_k127_1234715_2	1333523.L593_12055	3.398e-14	79.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,23W4C@183963|Halobacteria	183963|Halobacteria	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
MMD1_k127_1234715_1	444158.MmarC6_1174	1.289e-42	172.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD1_k127_1234715_0	439481.Aboo_0227	2.067e-53	200.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,3F2M2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMD1_k127_1237956_0	693661.Arcve_1931	5.055e-72	251.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2460M@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_1237956_1	456442.Mboo_2190	9.371e-57	211.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
MMD1_k127_124277_1	118168.MC7420_6504	2.971e-92	330.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
MMD1_k127_124277_0	292459.STH260	4.182e-95	324.0	COG4756@1|root,COG4756@2|Bacteria,1TR8T@1239|Firmicutes,24AUH@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1646)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1646
MMD1_k127_124277_2	1449126.JQKL01000039_gene1065	9.13e-84	301.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,2688V@186813|unclassified Clostridiales	186801|Clostridia	P	TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
MMD1_k127_124277_3	1501230.ET33_05625	1.383e-06	55.0	COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,4H9V6@91061|Bacilli,275JF@186822|Paenibacillaceae	91061|Bacilli	L	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR
MMD1_k127_124639_0	1216966.BAUC01000022_gene1705	3.737e-10	72.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
MMD1_k127_1250593_0	1236689.MMALV_16620	5.176e-47	177.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,3F2G4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DEAD/H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMD1_k127_1250866_4	344747.PM8797T_15566	5.502e-08	60.0	COG2204@1|root,COG2204@2|Bacteria,2IY95@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMD1_k127_1250866_1	416348.Hlac_2824	8.678e-60	231.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_1250866_5	662479.C440_02633	0.0001299	55.0	arCOG02497@1|root,arCOG02497@2157|Archaea	2157|Archaea	P	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
MMD1_k127_1250866_0	387631.Asulf_00201	1.154e-111	379.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,245NJ@183980|Archaeoglobi	183980|Archaeoglobi	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMD1_k127_1250866_2	386456.JQKN01000013_gene3015	7.963e-17	83.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
MMD1_k127_1250866_3	1236689.MMALV_02530	1.019e-08	63.0	arCOG06958@1|root,arCOG06958@2157|Archaea,2Y41U@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1274798_1	1121405.dsmv_0931	2.589e-86	291.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MI50@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
MMD1_k127_1274798_0	316067.Geob_1368	1.045e-100	342.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,42Q04@68525|delta/epsilon subdivisions,2WKF7@28221|Deltaproteobacteria,43S5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Transketolase, pyrimidine binding domain	tklB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMD1_k127_1274798_2	1121430.JMLG01000004_gene963	5.087e-31	124.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMD1_k127_1277411_6	1128421.JAGA01000003_gene3261	2.386e-41	157.0	COG0241@1|root,COG0241@2|Bacteria,2NPK4@2323|unclassified Bacteria	2|Bacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	2.7.7.71,3.1.3.82,3.1.3.83	ko:K03273,ko:K15669	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771,R09772	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iIT341.HP0860	HAD_2,Hydrolase_like,NTP_transferase,PNK3P
MMD1_k127_1277411_7	368408.Tpen_1509	6.119e-07	60.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	deoR2	-	3.6.4.12,4.2.3.1,6.3.4.15	ko:K01733,ko:K02039,ko:K03436,ko:K03524,ko:K03655	ko00260,ko00750,ko00780,ko01100,ko01110,ko01120,ko01230,ko03440,map00260,map00750,map00780,map01100,map01110,map01120,map01230,map03440	M00018	R01074,R01466,R05086,R05145	RC00017,RC00043,RC00070,RC00096,RC00526,RC02896	ko00000,ko00001,ko00002,ko01000,ko03000,ko03400	-	-	-	BPL_C,BPL_LplA_LipB,DeoRC,HTH_11,HTH_24,HTH_DeoR,MarR_2,PhoU
MMD1_k127_1277411_0	1499967.BAYZ01000013_gene6439	4.175e-237	752.0	COG1331@1|root,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
MMD1_k127_1277411_3	373903.Hore_15950	1.287e-51	190.0	COG0778@1|root,COG0778@2|Bacteria,1V49Q@1239|Firmicutes,24IH8@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMD1_k127_1277411_4	648996.Theam_0591	9.682e-50	187.0	COG1225@1|root,COG1225@2|Bacteria,2G42T@200783|Aquificae	200783|Aquificae	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMD1_k127_1277411_5	69014.TK0815	2.905e-46	172.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2440M@183968|Thermococci	183968|Thermococci	O	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
MMD1_k127_1277411_2	338966.Ppro_0548	6.332e-120	391.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,43W11@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMD1_k127_1277411_1	604354.TSIB_1902	3.958e-195	623.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,243RK@183968|Thermococci	183968|Thermococci	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
MMD1_k127_1300754_0	416348.Hlac_2824	7.042e-35	155.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_1300754_2	247490.KSU1_B0388	2.249e-20	100.0	COG0655@1|root,COG0655@2|Bacteria,2J3H1@203682|Planctomycetes	203682|Planctomycetes	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD1_k127_1300754_1	387631.Asulf_00513	8.711e-34	136.0	COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,2469B@183980|Archaeoglobi	183980|Archaeoglobi	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
MMD1_k127_1314626_2	83406.HDN1F_22540	4.668e-28	114.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1J7CN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
MMD1_k127_1314626_3	330214.NIDE4138	1.183e-13	83.0	COG2146@1|root,COG2146@2|Bacteria,3J1E7@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
MMD1_k127_1314626_0	521011.Mpal_0988	5.075e-81	285.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
MMD1_k127_1314626_1	1094980.Mpsy_1949	1.847e-60	213.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBNA@224756|Methanomicrobia	224756|Methanomicrobia	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
MMD1_k127_1328509_0	266117.Rxyl_1964	4.319e-184	602.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2GJU7@201174|Actinobacteria,4CPD0@84995|Rubrobacteria	84995|Rubrobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMD1_k127_1328509_1	420247.Msm_1483	3.451e-100	339.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,23PFF@183925|Methanobacteria	183925|Methanobacteria	E	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_1328509_2	868131.MSWAN_1557	3.377e-53	207.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD1_k127_1345925_0	237368.SCABRO_01899	2.217e-62	228.0	COG0312@1|root,COG0312@2|Bacteria,2J2PJ@203682|Planctomycetes	203682|Planctomycetes	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
MMD1_k127_1345925_1	246969.TAM4_40	1.197e-14	87.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD1_k127_1349852_1	797114.C475_09614	1.419e-05	58.0	COG1520@1|root,COG3291@1|root,arCOG03441@1|root,arCOG03991@1|root,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG02546@2157|Archaea,arCOG03441@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Malectin,PKD,Pilin_N,SdrD_B
MMD1_k127_1349852_0	861360.AARI_13980	1.337e-14	88.0	COG3087@1|root,COG3291@1|root,COG3087@2|Bacteria,COG3291@2|Bacteria,2HESC@201174|Actinobacteria,1W8TS@1268|Micrococcaceae	201174|Actinobacteria	D	Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Fibrinogen_C
MMD1_k127_1356127_0	1236689.MMALV_02290	1.381e-44	178.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,3F2QB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	snoRNA binding domain, fibrillarin	nop5	GO:0000154,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030515,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMD1_k127_1362095_0	316067.Geob_0814	2.118e-20	107.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_1362758_2	696281.Desru_1332	8.769e-44	175.0	COG0297@1|root,COG0297@2|Bacteria,1UHYC@1239|Firmicutes,24ANR@186801|Clostridia,260MR@186807|Peptococcaceae	186801|Clostridia	G	PFAM Glycosyl transferase, group 1	-	-	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_1362758_0	1379698.RBG1_1C00001G1247	2.217e-116	385.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,2NNXZ@2323|unclassified Bacteria	2|Bacteria	E	Formiminotransferase-cyclodeaminase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K01746,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
MMD1_k127_1362758_3	742740.HMPREF9474_03416	2.634e-35	149.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,223XR@1506553|Lachnoclostridium	186801|Clostridia	E	Formiminotransferase-cyclodeaminase	fchA	-	4.3.1.4	ko:K01746	ko00670,ko01100,map00670,map01100	-	R02302	RC00688	ko00000,ko00001,ko01000	-	-	-	FTCD_C
MMD1_k127_1362758_4	673860.AciM339_0907	2.887e-12	81.0	COG1361@1|root,arCOG02527@1|root,arCOG02089@2157|Archaea,arCOG02527@2157|Archaea,2Y6ZW@28890|Euryarchaeota,3F314@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1362758_1	545695.TREAZ_2782	5.752e-102	346.0	COG2309@1|root,COG2309@2|Bacteria,2J605@203691|Spirochaetes	203691|Spirochaetes	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
MMD1_k127_1362758_5	439481.Aboo_0010	6.934e-10	74.0	COG1361@1|root,COG1572@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG02079@2157|Archaea,arCOG02532@2157|Archaea,2Y1TH@28890|Euryarchaeota,3F2UJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DZR,zinc_ribbon_2
MMD1_k127_1363364_1	383372.Rcas_3282	4.542e-35	139.0	COG1208@1|root,COG1208@2|Bacteria,2G65W@200795|Chloroflexi,376T2@32061|Chloroflexia	32061|Chloroflexia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD1_k127_1363364_3	673860.AciM339_0383	9.329e-15	89.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0B2@28890|Euryarchaeota,3F2ST@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMD1_k127_1363364_0	304371.MCP_2998	9.875e-111	379.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
MMD1_k127_1363364_4	566461.SSFG_00091	4.444e-06	60.0	2B7WC@1|root,3213B@2|Bacteria,2H50F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1363364_2	1041930.Mtc_2505	5.992e-25	115.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMD1_k127_1368009_1	1136163.M565_ctg5P0502	2.256e-10	74.0	COG2911@1|root,COG3209@1|root,COG4676@1|root,COG5295@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG4676@2|Bacteria,COG5295@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,DUF5122,He_PIG,OmpA_membrane
MMD1_k127_1368009_0	439481.Aboo_0742	8.158e-195	634.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,3F2EU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMD1_k127_1374569_0	673860.AciM339_1505	1.822e-191	621.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,3F2HN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	MCM OB domain	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	HTH_3,Intein_splicing,LAGLIDADG_3,MCM,MCM_N,MCM_OB
MMD1_k127_1383882_1	1457250.BBMO01000002_gene2337	1.065e-16	93.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,23TF3@183963|Halobacteria	183963|Halobacteria	L	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
MMD1_k127_1383882_0	1094980.Mpsy_3151	3.471e-30	140.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1383882_2	1163407.UU7_02797	2.857e-13	84.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1X3BD@135614|Xanthomonadales	135614|Xanthomonadales	E	Transglutaminase/protease-like homologues	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
MMD1_k127_1383882_3	525904.Tter_2362	1.796e-06	54.0	COG0785@1|root,COG0785@2|Bacteria,2NRAI@2323|unclassified Bacteria	2|Bacteria	O	PFAM Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
MMD1_k127_1383956_2	304371.MCP_0344	1.327e-87	314.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMD1_k127_1383956_8	1448860.BBJO01000003_gene2633	5.207e-10	62.0	COG0636@1|root,arCOG02455@2157|Archaea,2XZRP@28890|Euryarchaeota,23XH5@183963|Halobacteria	183963|Halobacteria	C	F0F1-type ATP synthase, subunit c archaeal vacuolar-type H -ATPase, subunit K	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMD1_k127_1383956_6	565033.GACE_1734	5.106e-25	111.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,24687@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
MMD1_k127_1383956_5	351160.RCIX2028	2.594e-63	230.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2N9HH@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0388	vATP-synt_AC39
MMD1_k127_1383956_7	593750.Metfor_0314	3.918e-18	88.0	COG1436@1|root,arCOG04102@2157|Archaea,2XXYI@28890|Euryarchaeota,2N9YY@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMD1_k127_1383956_0	1094980.Mpsy_2506	8.382e-257	806.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,2N93M@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMD1_k127_1383956_1	1041930.Mtc_1395	1.977e-239	758.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2N97D@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMD1_k127_1383956_3	351160.RCIX2034	2.01e-71	249.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,2N9IG@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
MMD1_k127_1383956_4	1192034.CAP_5621	8.42e-68	259.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1P2CI@1224|Proteobacteria	1224|Proteobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
MMD1_k127_1386357_1	1348583.ATLH01000017_gene2671	4.655e-08	65.0	COG3291@1|root,COG3291@2|Bacteria,4PHZA@976|Bacteroidetes,1IGQC@117743|Flavobacteriia,1F9WN@104264|Cellulophaga	976|Bacteroidetes	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_1386357_0	1198449.ACAM_0667	5.662e-15	77.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMD1_k127_1395563_2	269797.Mbar_A1372	1.443e-60	216.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,2N9JI@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
MMD1_k127_1395563_1	1094980.Mpsy_1566	7.15e-66	237.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMD1_k127_1395563_4	237368.SCABRO_03141	1.509e-07	61.0	COG2129@1|root,COG2129@2|Bacteria,2J1K1@203682|Planctomycetes	203682|Planctomycetes	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
MMD1_k127_1395563_3	1184251.TCELL_0381	4.857e-08	57.0	COG2157@1|root,arCOG04175@2157|Archaea,2XR3H@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Ribosomal L18ae LX protein domain	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
MMD1_k127_1395563_5	1041930.Mtc_0441	4.218e-07	60.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMD1_k127_1395563_0	439481.Aboo_1259	8.868e-101	350.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,3F2GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMD1_k127_1402576_1	246197.MXAN_1605	5.1e-05	54.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42NUK@68525|delta/epsilon subdivisions,2WJTJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_1402576_0	348780.NP_5062A	2.161e-41	166.0	COG1520@1|root,arCOG02556@2157|Archaea,2Y7Q9@28890|Euryarchaeota,240XC@183963|Halobacteria	183963|Halobacteria	C	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
MMD1_k127_1412780_0	90814.KL370892_gene2138	3.644e-07	63.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMD1_k127_1416025_5	69014.TK0691	5.812e-12	73.0	arCOG03805@1|root,arCOG03803@2157|Archaea,2Y30J@28890|Euryarchaeota,242VU@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF835
MMD1_k127_1416025_1	439481.Aboo_0301	2.285e-114	395.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,3F2JH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	vorB	-	1.2.7.1,1.2.7.7	ko:K00170,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD1_k127_1416025_0	673860.AciM339_0764	1.229e-130	432.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,3F36A@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Pyruvate:ferredoxin oxidoreductase core domain II	vorA	-	1.2.7.1,1.2.7.7	ko:K00169,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMD1_k127_1416025_4	439481.Aboo_0299	8.03e-25	108.0	COG1144@1|root,arCOG01605@2157|Archaea,2Y02N@28890|Euryarchaeota,3F3EX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	porD	-	1.2.7.1,1.2.7.7	ko:K00171,ko:K00188	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
MMD1_k127_1416025_2	673860.AciM339_0766	1.511e-58	208.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,3F2RB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porC	-	1.2.7.1,1.2.7.7	ko:K00172,ko:K00189	ko00010,ko00020,ko00280,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R07160,R08034,R08566,R08567	RC00004,RC00250,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMD1_k127_1416025_3	673860.AciM339_0759	3.764e-46	178.0	COG1468@1|root,arCOG00786@2157|Archaea,2Y71A@28890|Euryarchaeota,3F34X@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	TIGRFAM CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PDDEXK_1
MMD1_k127_1416349_0	985053.VMUT_0747	6.444e-62	228.0	COG0351@1|root,COG1992@1|root,arCOG00020@2157|Archaea,arCOG00021@2157|Archaea,2XPQB@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Phosphomethylpyrimidine kinase	thiDN	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219,ko:K21220	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
MMD1_k127_1416349_2	1064537.AGSO01000006_gene1942	3.232e-06	58.0	COG1387@1|root,COG1387@2|Bacteria,2HYSU@201174|Actinobacteria,4FC15@85020|Dermabacteraceae	201174|Actinobacteria	E	PHP domain	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
MMD1_k127_1416349_1	383372.Rcas_3603	4.152e-36	145.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
MMD1_k127_1423227_1	1041930.Mtc_1252	7.246e-82	294.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMD1_k127_1423227_0	368407.Memar_1626	1.907e-119	393.0	COG0863@1|root,arCOG00115@2157|Archaea,2XWB2@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMD1_k127_1423227_2	589924.Ferp_1587	0.0003982	46.0	arCOG10363@1|root,arCOG10363@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1425947_1	1232410.KI421417_gene2716	5.076e-98	354.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD1_k127_1425947_0	224325.AF_1424	2.299e-135	451.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,245T6@183980|Archaeoglobi	183980|Archaeoglobi	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
MMD1_k127_1451300_2	572546.Arcpr_0133	1.511e-30	127.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,246C1@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
MMD1_k127_1451300_1	69014.TK1501	6.992e-40	156.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,243ZW@183968|Thermococci	183968|Thermococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMD1_k127_1451300_0	439481.Aboo_1476	1.649e-46	178.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,3F2N4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the universal ribosomal protein uS9 family	rps9	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMD1_k127_1451300_3	604354.TSIB_0346	9.264e-20	93.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,244I0@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMD1_k127_1459776_0	572546.Arcpr_1629	1.865e-149	484.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,246U9@183980|Archaeoglobi	183980|Archaeoglobi	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
MMD1_k127_1459776_2	439481.Aboo_1419	2.942e-33	135.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,3F2TJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
MMD1_k127_1459776_1	401526.TcarDRAFT_0813	3.511e-36	145.0	COG1335@1|root,COG1335@2|Bacteria,1V5TQ@1239|Firmicutes	1239|Firmicutes	Q	isochorismatase	entB	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMD1_k127_1468542_0	292459.STH1757	2.069e-137	455.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMD1_k127_1468542_8	1033810.HLPCO_000903	5.149e-26	114.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	yokL3	-	2.3.1.57	ko:K00657,ko:K07023	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
MMD1_k127_1468542_7	444157.Tneu_1635	4.088e-41	169.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
MMD1_k127_1468542_1	1236689.MMALV_13970	5.408e-136	460.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,3F2N6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	tRNA synthetases class I (W and Y)	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMD1_k127_1468542_6	330779.Saci_1837	2.923e-42	169.0	COG0436@1|root,arCOG04333@2157|Archaea,2XQ9N@28889|Crenarchaeota	28889|Crenarchaeota	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMD1_k127_1468542_2	552811.Dehly_0088	6.992e-75	263.0	COG1230@1|root,COG1230@2|Bacteria,2G6FI@200795|Chloroflexi,34D5R@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
MMD1_k127_1468542_9	1121438.JNJA01000002_gene3644	1.25e-11	75.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,42QP3@68525|delta/epsilon subdivisions,2WMTD@28221|Deltaproteobacteria,2MA2W@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMD1_k127_1468542_5	1094980.Mpsy_1084	8.966e-54	217.0	COG1138@1|root,arCOG00270@2157|Archaea,2XUDS@28890|Euryarchaeota,2NADH@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	Cytochrom_C_asm
MMD1_k127_1468542_3	565033.GACE_0364	1.409e-70	251.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,24632@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
MMD1_k127_1468542_4	673860.AciM339_0364	9.122e-60	216.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,3F2PP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Carbon-nitrogen hydrolase	-	-	3.5.1.100	ko:K18540	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
MMD1_k127_1475571_2	268739.Nmlp_3511	6.121e-11	64.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,23SSR@183963|Halobacteria	183963|Halobacteria	O	Belongs to the TCP-1 chaperonin family	ths1	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMD1_k127_1475571_0	1501230.ET33_13240	3.671e-82	281.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
MMD1_k127_1475571_1	694429.Pyrfu_0108	1.714e-41	157.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMD1_k127_1477491_5	243274.THEMA_00935	1.45e-10	64.0	COG0438@1|root,COG0438@2|Bacteria,2GCQU@200918|Thermotogae	200918|Thermotogae	M	PFAM glycosyl transferase group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_1477491_2	195522.BD01_0289	4.669e-32	138.0	COG0438@1|root,arCOG01403@2157|Archaea,2XYCV@28890|Euryarchaeota,245MP@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_1477491_3	679926.Mpet_1499	1.919e-24	109.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZVP@28890|Euryarchaeota,2NA27@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
MMD1_k127_1477491_4	1535287.JP74_06790	1.637e-13	75.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,3N718@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMD1_k127_1477491_1	1094508.Tsac_1995	1.348e-66	246.0	COG0020@1|root,COG0020@2|Bacteria,1TRKB@1239|Firmicutes,248R2@186801|Clostridia,42HZM@68295|Thermoanaerobacterales	186801|Clostridia	I	Putative undecaprenyl diphosphate synthase	uppS1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
MMD1_k127_1477491_0	698757.Pogu_0973	2.317e-98	332.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMD1_k127_1478573_0	439481.Aboo_0743	2.255e-167	534.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,3F2HT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
MMD1_k127_1483473_1	573063.Metin_1275	1.365e-45	169.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,23QST@183939|Methanococci	183939|Methanococci	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMD1_k127_1483473_0	1236689.MMALV_15590	2.158e-51	200.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,3F2M1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
MMD1_k127_1483473_2	1235803.C825_04290	1.409e-08	67.0	COG1470@1|root,COG1470@2|Bacteria,4NHIX@976|Bacteroidetes,2FN9I@200643|Bacteroidia,22WAR@171551|Porphyromonadaceae	976|Bacteroidetes	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
MMD1_k127_1490489_0	1054217.TALC_00511	9.632e-115	384.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
MMD1_k127_1490489_1	1343739.PAP_03695	5.7e-39	150.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2445F@183968|Thermococci	183968|Thermococci	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
MMD1_k127_1490575_2	1324957.K933_11341	2.079e-33	137.0	COG0688@1|root,arCOG04470@2157|Archaea,2XX5J@28890|Euryarchaeota,23TM1@183963|Halobacteria	183963|Halobacteria	I	phosphatidylserine decarboxylase	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
MMD1_k127_1490575_3	1261545.MBE-HAL_1225	3.114e-19	98.0	COG1183@1|root,arCOG00671@2157|Archaea,2XT0G@28890|Euryarchaeota,23TMI@183963|Halobacteria	183963|Halobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
MMD1_k127_1490575_1	673860.AciM339_0768	2.454e-59	212.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,3F2MF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMD1_k127_1490575_0	523850.TON_0648	1.885e-61	228.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,243GQ@183968|Thermococci	183968|Thermococci	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMD1_k127_1497179_2	329726.AM1_0604	7.177e-15	83.0	COG0611@1|root,COG0611@2|Bacteria,1G1ZP@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMD1_k127_1497179_3	304371.MCP_1964	2.001e-05	57.0	arCOG04973@1|root,arCOG04973@2157|Archaea,2XX73@28890|Euryarchaeota,2N9K2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1497179_0	771875.Ferpe_2062	3.652e-97	329.0	COG0549@1|root,COG0549@2|Bacteria,2GCB0@200918|Thermotogae	200918|Thermotogae	E	Belongs to the carbamate kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD1_k127_1497179_1	439481.Aboo_0448	3.981e-32	137.0	COG2339@1|root,arCOG02985@2157|Archaea	2157|Archaea	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
MMD1_k127_1524991_0	1347368.HG964403_gene4490	6.439e-56	222.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMD1_k127_1531666_0	456442.Mboo_1834	1.611e-74	259.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,2N9FX@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
MMD1_k127_153863_0	529709.PYCH_16880	2.279e-129	437.0	COG1297@1|root,arCOG04807@2157|Archaea,2XVCD@28890|Euryarchaeota,243GY@183968|Thermococci	183968|Thermococci	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
MMD1_k127_153863_3	351160.RCIX443	6.682e-28	120.0	COG0745@1|root,arCOG02595@2157|Archaea,2XZSB@28890|Euryarchaeota,2NAXV@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	ko:K07668	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
MMD1_k127_153863_2	523845.AQXV01000053_gene681	9.174e-56	215.0	COG0840@1|root,arCOG02320@2157|Archaea,2Y7QV@28890|Euryarchaeota,23RVM@183939|Methanococci	183939|Methanococci	T	Integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
MMD1_k127_153863_1	1232410.KI421412_gene323	4.098e-106	361.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,42MPV@68525|delta/epsilon subdivisions,2WJBH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMD1_k127_1544088_4	1120983.KB894574_gene808	4.842e-09	61.0	COG0596@1|root,COG0596@2|Bacteria,1PFTV@1224|Proteobacteria,2V8R3@28211|Alphaproteobacteria,1JQG3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1544088_2	868131.MSWAN_2165	6.138e-137	448.0	COG2327@1|root,arCOG04826@2157|Archaea	2157|Archaea	S	PFAM Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
MMD1_k127_1544088_0	868131.MSWAN_2166	9.419e-308	969.0	COG0451@1|root,COG1022@1|root,arCOG01369@2157|Archaea,arCOG04199@2157|Archaea	2157|Archaea	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,Epimerase,NAD_binding_4
MMD1_k127_1544088_3	386456.JQKN01000016_gene923	1.329e-39	171.0	arCOG08232@1|root,arCOG08232@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
MMD1_k127_1544088_1	868131.MSWAN_2168	2.875e-164	538.0	COG2303@1|root,arCOG02232@2157|Archaea,2Y89C@28890|Euryarchaeota,23NTI@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Glucose-methanol-choline oxidoreductase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_N
MMD1_k127_1544637_2	768706.Desor_4465	3.645e-69	250.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,260C4@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS12480	HpcH_HpaI,Malate_synthase
MMD1_k127_1544637_1	633148.Tagg_1018	2.634e-76	271.0	COG0045@1|root,arCOG01337@2157|Archaea,2XPUW@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMD1_k127_1544637_0	415426.Hbut_0202	8.414e-97	327.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
MMD1_k127_1545534_0	1236689.MMALV_03850	5.19e-35	138.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,3F2SI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
MMD1_k127_1545534_1	649747.HMPREF0083_03812	3.35e-25	120.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1TRC3@1239|Firmicutes,4HADQ@91061|Bacilli,26R5S@186822|Paenibacillaceae	91061|Bacilli	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
MMD1_k127_1546160_0	521011.Mpal_1222	3.599e-129	419.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota	28890|Euryarchaeota	O	AIR synthase related protein domain protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
MMD1_k127_1546160_3	247490.KSU1_C1639	1.799e-24	108.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
MMD1_k127_1546160_6	273075.Ta1144a	6.615e-05	51.0	COG5466@1|root,arCOG05278@2157|Archaea,2Y5U3@28890|Euryarchaeota,242H8@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMD1_k127_1546160_5	880072.Desac_0254	3.964e-20	93.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,NHL,Thioredoxin_8
MMD1_k127_1546160_2	644966.Tmar_1673	2.073e-110	368.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia	186801|Clostridia	C	dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMD1_k127_1546160_1	469383.Cwoe_2192	1.752e-118	395.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4CPUE@84995|Rubrobacteria	201174|Actinobacteria	C	PFAM Transketolase central region	pdhB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2496c	Transket_pyr,Transketolase_C
MMD1_k127_1546160_4	1089544.KB912942_gene362	1.301e-21	101.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4E04X@85010|Pseudonocardiales	201174|Actinobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMD1_k127_1563959_4	1089550.ATTH01000001_gene2050	2.14e-36	145.0	COG1028@1|root,COG1028@2|Bacteria,4PIW8@976|Bacteroidetes,1FK9V@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMD1_k127_1563959_3	673860.AciM339_0977	2.826e-42	157.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,3F2QH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMD1_k127_1563959_1	368407.Memar_0730	5.46e-199	627.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMD1_k127_1563959_0	673860.AciM339_0979	7.513e-311	967.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,3F2GN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMD1_k127_1563959_2	1054217.TALC_00387	5.807e-66	234.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,241NY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMD1_k127_1564403_1	351160.LRC265	9.765e-43	167.0	COG3390@1|root,arCOG02258@2157|Archaea,2XT3R@28890|Euryarchaeota,2N9P2@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
MMD1_k127_1564403_0	439481.Aboo_1488	2.674e-86	308.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,3F2KP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa1	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMD1_k127_1564403_2	439481.Aboo_0587	0.000488	48.0	COG2034@1|root,arCOG02717@2157|Archaea,2XZVB@28890|Euryarchaeota,3F3HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF131	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
MMD1_k127_1564423_1	469383.Cwoe_2655	1.931e-09	60.0	COG1933@1|root,COG1933@2|Bacteria,2GU4W@201174|Actinobacteria,4CQ2Q@84995|Rubrobacteria	84995|Rubrobacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
MMD1_k127_1564423_0	1457250.BBMO01000001_gene1581	1.524e-86	326.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_1566992_2	1198114.AciX9_2489	3.172e-10	74.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	wcoG	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,PKD
MMD1_k127_1566992_0	459349.CLOAM1622	6.076e-17	96.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Cleaved_Adhesin,FlgD_ig,MAM
MMD1_k127_1566992_1	688270.Celal_3762	2.324e-15	87.0	COG3291@1|root,COG3291@2|Bacteria,4PHZA@976|Bacteroidetes,1IGQC@117743|Flavobacteriia,1F9WN@104264|Cellulophaga	976|Bacteroidetes	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_1571426_0	1301100.HG529352_gene4264	2.185e-29	123.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,24MN5@186801|Clostridia,36KQB@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
MMD1_k127_1571426_1	665571.STHERM_c18140	4.959e-05	56.0	COG0577@1|root,COG0577@2|Bacteria,2J6VD@203691|Spirochaetes	203691|Spirochaetes	V	Permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_1571931_0	1457250.BBMO01000001_gene1581	6.272e-48	192.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_1587476_0	1054217.TALC_01537	3.681e-55	200.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,242ID@183967|Thermoplasmata	28890|Euryarchaeota	C	4Fe-4S dicluster domain	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
MMD1_k127_1587476_1	1385520.N802_04015	5.589e-23	111.0	COG0382@1|root,COG0382@2|Bacteria,2IJV5@201174|Actinobacteria	201174|Actinobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_1587476_2	246194.CHY_0260	1.063e-12	81.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto,Paired_CXXCH_1
MMD1_k127_1596125_2	351160.RCIX1700	3.887e-41	158.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXTN@28890|Euryarchaeota,2NB5F@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
MMD1_k127_1596125_0	717606.PaecuDRAFT_2033	1.729e-113	411.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_1596125_1	1246995.AFR_22960	1.71e-57	231.0	COG4733@1|root,COG4733@2|Bacteria,2H7QD@201174|Actinobacteria,4DJZF@85008|Micromonosporales	201174|Actinobacteria	NU	Fibronectin type III domain	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	fn3
MMD1_k127_1652384_5	1132509.C447_07228	2.325e-13	72.0	arCOG03570@1|root,arCOG03570@2157|Archaea,2XXVH@28890|Euryarchaeota,23WCU@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMD1_k127_1652384_0	688269.Theth_0193	4.459e-97	323.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_1652384_1	688269.Theth_0192	1.561e-85	302.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD1_k127_1652384_2	926560.KE387025_gene4131	1.102e-72	255.0	COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMD1_k127_1652384_6	1459636.NTE_00644	8.559e-12	74.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1652384_3	509191.AEDB02000022_gene3039	2.799e-28	128.0	COG4908@1|root,COG4908@2|Bacteria,1V0U5@1239|Firmicutes,25D3E@186801|Clostridia,3WK8S@541000|Ruminococcaceae	186801|Clostridia	S	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
MMD1_k127_1657434_7	1071085.KK033114_gene421	6.808e-08	65.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,23SPN@183963|Halobacteria	183963|Halobacteria	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
MMD1_k127_1657434_1	1236689.MMALV_01380	1.618e-85	298.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,3F2J3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMD1_k127_1657434_4	1457250.BBMO01000001_gene1581	9.808e-30	135.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_1657434_6	1041930.Mtc_0986	8.932e-14	81.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2Y0M6@28890|Euryarchaeota,2N9ZD@224756|Methanomicrobia	224756|Methanomicrobia	U	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1657434_0	439481.Aboo_0009	2.303e-185	597.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F2TI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMD1_k127_1657434_2	439481.Aboo_0007	6.661e-60	220.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F36C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD1_k127_1657434_3	439481.Aboo_0008	5.138e-54	205.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F37F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD1_k127_1657434_5	1033806.HTIA_p2905	1.138e-28	134.0	COG3534@1|root,arCOG10185@2157|Archaea,2XVXP@28890|Euryarchaeota,23USN@183963|Halobacteria	183963|Halobacteria	G	Alpha-L-arabinofuranosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-L-AF_C
MMD1_k127_1662742_0	59374.Fisuc_0063	7.691e-19	103.0	COG2911@1|root,COG4254@1|root,COG2911@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	lgt	-	-	ko:K09800,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000	-	-	-	FecR
MMD1_k127_1662742_1	660470.Theba_2153	1.649e-18	101.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF285,Flg_new,He_PIG,LVIVD,PKD,RHS_repeat
MMD1_k127_1680400_0	511051.CSE_15390	4.114e-23	115.0	COG1502@1|root,COG2374@1|root,COG1502@2|Bacteria,COG2374@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	xynX1	-	3.1.3.8	ko:K01083,ko:K06131,ko:K06915	ko00562,ko00564,ko01100,map00562,map00564,map01100	-	R03371,R07390	RC00017,RC00078	ko00000,ko00001,ko01000	-	-	-	Exo_endo_phos,F5_F8_type_C,LTD,PLDc_2,SLH
MMD1_k127_1680400_1	673860.AciM339_0905	2.206e-11	73.0	COG0640@1|root,arCOG03067@2157|Archaea,2Y747@28890|Euryarchaeota,3F3DB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMD1_k127_1680400_2	439481.Aboo_0153	0.0009654	52.0	COG1572@1|root,arCOG03999@1|root,arCOG05978@1|root,arCOG02532@2157|Archaea,arCOG03999@2157|Archaea,arCOG05978@2157|Archaea,2Y4KU@28890|Euryarchaeota	28890|Euryarchaeota	E	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C11
MMD1_k127_1687937_0	1089548.KI783301_gene1776	3.989e-07	64.0	COG3210@1|root,COG3507@1|root,COG4733@1|root,COG5184@1|root,COG3210@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,1VW0A@1239|Firmicutes,4HWE6@91061|Bacilli,3WFP4@539002|Bacillales incertae sedis	2|Bacteria	DZ	S-layer homology domain	Tnr	-	3.2.1.8	ko:K01181,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	SLH
MMD1_k127_169850_3	1227487.C474_10451	1.039e-05	59.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUYS@28890|Euryarchaeota,23V04@183963|Halobacteria	183963|Halobacteria	S	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
MMD1_k127_169850_2	485914.Hmuk_0677	1.645e-31	143.0	COG1520@1|root,arCOG02556@2157|Archaea,2Y7Q9@28890|Euryarchaeota,240XC@183963|Halobacteria	183963|Halobacteria	C	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
MMD1_k127_169850_1	96561.Dole_2226	1.741e-154	502.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,42MN0@68525|delta/epsilon subdivisions,2WJ7P@28221|Deltaproteobacteria,2MIXW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminopeptidase I zinc metalloprotease (M18)	apeA	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
MMD1_k127_169850_0	370438.PTH_2720	5.663e-181	582.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,2602C@186807|Peptococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
MMD1_k127_170368_7	177437.HRM2_17030	1.488e-07	62.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2MHTY@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
MMD1_k127_170368_5	589924.Ferp_2240	7.843e-26	114.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2466S@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMD1_k127_170368_2	673860.AciM339_1060	1.059e-87	317.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,3F2WK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMD1_k127_170368_3	304371.MCP_2721	1.268e-77	271.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2NAI6@224756|Methanomicrobia	224756|Methanomicrobia	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMD1_k127_170368_8	589924.Ferp_1928	3.009e-07	57.0	2BVY9@1|root,2N553@2157|Archaea,2Y1ZH@28890|Euryarchaeota,246I9@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_170368_1	589924.Ferp_2374	9.854e-105	354.0	COG1208@1|root,arCOG00668@2157|Archaea,2Y87G@28890|Euryarchaeota,2462R@183980|Archaeoglobi	183980|Archaeoglobi	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD1_k127_170368_0	1094980.Mpsy_2689	1.281e-183	591.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,2N92X@224756|Methanomicrobia	224756|Methanomicrobia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMD1_k127_170368_4	868131.MSWAN_1817	1.016e-55	204.0	COG5485@1|root,arCOG06513@2157|Archaea,2Y3E5@28890|Euryarchaeota	28890|Euryarchaeota	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
MMD1_k127_170368_6	397278.JOJN01000015_gene3461	2.41e-08	67.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DPKW@85009|Propionibacteriales	201174|Actinobacteria	EU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
MMD1_k127_1711090_1	1157490.EL26_09260	2.818e-45	174.0	COG0555@1|root,COG0555@2|Bacteria,1TQHR@1239|Firmicutes,4HFC4@91061|Bacilli,279RY@186823|Alicyclobacillaceae	91061|Bacilli	O	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
MMD1_k127_1711090_0	1288079.AUKN01000020_gene2609	2.115e-83	290.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
MMD1_k127_1711090_2	1442599.JAAN01000023_gene1770	1.632e-06	57.0	COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,1S3KC@1236|Gammaproteobacteria,1X5GB@135614|Xanthomonadales	135614|Xanthomonadales	K	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,NTP_transf_2
MMD1_k127_17160_0	1298867.AUES01000076_gene4443	0.0008188	53.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2V8VX@28211|Alphaproteobacteria,3K1ZD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1719358_4	1379698.RBG1_1C00001G1092	3.22e-69	267.0	COG2866@1|root,COG4412@1|root,COG2866@2|Bacteria,COG4412@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.4.17.18,3.4.17.22	ko:K05996,ko:K07752	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	F5_F8_type_C,Peptidase_M14,Peptidase_M6,Ricin_B_lectin,fn3
MMD1_k127_1719358_0	555079.Toce_1201	7.654e-174	554.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMD1_k127_1719358_2	1499967.BAYZ01000196_gene3073	2.45e-101	362.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMD1_k127_1719358_3	552398.HMPREF0866_02341	5.338e-93	325.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia	186801|Clostridia	E	PFAM aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
MMD1_k127_1719358_1	401526.TcarDRAFT_1353	1.248e-135	445.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H24N@909932|Negativicutes	909932|Negativicutes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMD1_k127_1719358_5	324602.Caur_1384	7.602e-29	129.0	COG1184@1|root,COG1184@2|Bacteria,2G9CC@200795|Chloroflexi,3762Q@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
MMD1_k127_1719384_0	572546.Arcpr_0110	6.905e-81	279.0	COG1180@1|root,arCOG00947@2157|Archaea,2XWY1@28890|Euryarchaeota,246TQ@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMD1_k127_1719384_1	593750.Metfor_1801	1.403e-24	109.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y56Q@28890|Euryarchaeota	28890|Euryarchaeota	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
MMD1_k127_1719384_2	593750.Metfor_1800	2.957e-24	112.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
MMD1_k127_1719384_3	1121403.AUCV01000020_gene3109	1.912e-07	55.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
MMD1_k127_1727683_5	192952.MM_3074	1.186e-42	163.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
MMD1_k127_1727683_2	273116.14325261	1.796e-120	402.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMD1_k127_1727683_6	673860.AciM339_0467	3.804e-14	77.0	COG2768@1|root,arCOG02448@2157|Archaea,2Y7JX@28890|Euryarchaeota,3F2W9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMD1_k127_1727683_1	439481.Aboo_0580	1.638e-162	532.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,3F2FE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Intein_splicing,LAGLIDADG_3,Radical_SAM
MMD1_k127_1727683_3	673860.AciM339_1568	2.05e-57	213.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7FZ@28890|Euryarchaeota,3F2ZR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMD1_k127_1727683_0	523850.TON_0214	1.413e-177	569.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,242MV@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMD1_k127_1727683_4	1128421.JAGA01000002_gene784	3.993e-55	200.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
MMD1_k127_1735949_0	744979.R2A130_2658	1.502e-07	65.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,Calx-beta,DUF4214,DUF4347,He_PIG
MMD1_k127_1752163_3	1463887.KL590085_gene537	4.024e-22	111.0	COG1361@1|root,COG2706@1|root,COG1361@2|Bacteria,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,VCBS
MMD1_k127_1752163_0	930169.B5T_03190	4.271e-74	285.0	COG4932@1|root,COG4932@2|Bacteria,1QVU9@1224|Proteobacteria	1224|Proteobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD,REJ
MMD1_k127_1752163_5	439235.Dalk_2155	1.467e-19	106.0	COG2931@1|root,COG2931@2|Bacteria,1R094@1224|Proteobacteria	1224|Proteobacteria	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
MMD1_k127_1752163_2	264732.Moth_0444	7.728e-29	130.0	COG0644@1|root,COG0644@2|Bacteria,1UFA5@1239|Firmicutes,24CRV@186801|Clostridia,42F6K@68295|Thermoanaerobacterales	186801|Clostridia	C	NAD(P)-binding Rossmann-like domain	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	-
MMD1_k127_1752163_1	411464.DESPIG_01488	3.274e-31	135.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,2MCM3@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
MMD1_k127_1752163_4	1121324.CLIT_24c00190	1.738e-20	97.0	COG4359@1|root,COG4359@2|Bacteria,1TSZ9@1239|Firmicutes,24IHI@186801|Clostridia	186801|Clostridia	E	HAD-superfamily hydrolase, subfamily IB, PSPase-like	-	-	3.1.3.87	ko:K08966	ko00270,ko01100,map00270,map01100	M00034	R07394	RC02074	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Put_Phosphatase
MMD1_k127_1752163_6	492774.JQMB01000003_gene2631	0.0007961	48.0	COG4359@1|root,COG4359@2|Bacteria,1REUD@1224|Proteobacteria,2U9HY@28211|Alphaproteobacteria,4BCXJ@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Putative Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
MMD1_k127_1775549_0	1047013.AQSP01000059_gene2098	6.471e-132	430.0	COG0451@1|root,COG0451@2|Bacteria,2NQD6@2323|unclassified Bacteria	2|Bacteria	GM	RmlD substrate binding domain	ltd	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	Epimerase
MMD1_k127_1775549_1	566461.SSFG_06373	0.0006049	53.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1789267_2	56110.Oscil6304_1606	3.567e-05	58.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G2F0@1117|Cyanobacteria,1HF0C@1150|Oscillatoriales	1117|Cyanobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_1789267_0	436308.Nmar_1073	1.089e-59	237.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
MMD1_k127_1789267_1	870187.Thini_1774	3.664e-08	68.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMD1_k127_1793319_2	439481.Aboo_0078	6.926e-54	200.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,3F32I@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	Inositol_P,NAD_kinase
MMD1_k127_1793319_4	192952.MM_2631	3.662e-29	125.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,2N9TM@224756|Methanomicrobia	224756|Methanomicrobia	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
MMD1_k127_1793319_3	1499684.CCNP01000010_gene43	5.124e-37	153.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
MMD1_k127_1793319_1	1121324.CLIT_2c03230	1.221e-58	216.0	COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia	186801|Clostridia	H	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
MMD1_k127_1793319_5	246969.TAM4_812	4.364e-14	83.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2436S@183968|Thermococci	183968|Thermococci	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMD1_k127_1793319_0	517418.Ctha_1417	1.021e-77	275.0	COG1899@1|root,COG1899@2|Bacteria,1FDI8@1090|Chlorobi	1090|Chlorobi	H	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMD1_k127_1793319_6	694429.Pyrfu_1149	3.428e-08	68.0	COG1470@1|root,COG2319@1|root,arCOG03264@1|root,arCOG02087@2157|Archaea,arCOG02491@2157|Archaea,arCOG03264@2157|Archaea,2XRJZ@28889|Crenarchaeota	28889|Crenarchaeota	S	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1794851_2	1094980.Mpsy_2329	1.134e-09	70.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2N9VN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
MMD1_k127_1794851_1	386456.JQKN01000004_gene170	5.845e-11	66.0	COG2002@1|root,arCOG00822@2157|Archaea,2Y5A3@28890|Euryarchaeota	28890|Euryarchaeota	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
MMD1_k127_1794851_0	877455.Metbo_1475	5.229e-97	323.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system ATPase component	nosF1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD1_k127_1798320_3	414684.RC1_3822	7.663e-43	181.0	COG3898@1|root,COG3898@2|Bacteria,1R052@1224|Proteobacteria	1224|Proteobacteria	S	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1798320_4	368407.Memar_2295	1.195e-12	77.0	COG2426@1|root,arCOG01330@2157|Archaea,2Y4KG@28890|Euryarchaeota	28890|Euryarchaeota	S	Small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
MMD1_k127_1798320_2	1236689.MMALV_03070	4.052e-46	177.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,3F2TS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Calcineurin-like phosphoesterase superfamily domain	rpe	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
MMD1_k127_1798320_1	439481.Aboo_1417	7.32e-54	196.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,3F30G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	pyrE1	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMD1_k127_1798320_0	386456.JQKN01000009_gene1093	1.292e-100	349.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,23NWD@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMD1_k127_1809337_4	7668.SPU_005613-tr	1.02e-27	133.0	KOG0613@1|root,KOG0613@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria	33208|Metazoa	T	myosin light chain kinase activity	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	I-set,Pkinase,fn3
MMD1_k127_1809337_0	251221.35214774	2.853e-90	338.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
MMD1_k127_1809337_3	10224.XP_006823012.1	1.143e-35	159.0	KOG0613@1|root,KOG0613@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria	33208|Metazoa	T	myosin light chain kinase activity	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	I-set,fn3
MMD1_k127_1809337_1	717606.PaecuDRAFT_2033	2.762e-80	305.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_1809337_2	1236689.MMALV_02090	5.375e-54	202.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,3F2EW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11,1.5.5.1	ko:K00311,ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3,FAD_oxidored,Lycopene_cycl,Trp_halogenase
MMD1_k127_1824209_0	368407.Memar_0328	2.788e-111	370.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD1_k127_1824209_1	868131.MSWAN_1992	3.305e-55	214.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota	28890|Euryarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMD1_k127_1824209_2	192952.MM_1849	6.609e-28	127.0	COG0644@1|root,arCOG00570@2157|Archaea	2157|Archaea	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
MMD1_k127_1824209_3	926554.KI912633_gene3749	7.589e-05	56.0	COG3271@1|root,COG3271@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_C39_2
MMD1_k127_183644_0	1444711.CCJF01000004_gene2369	3.048e-62	243.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,SBBP
MMD1_k127_183644_1	10224.XP_006823014.1	2.55e-20	107.0	KOG0613@1|root,KOG0613@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria	33208|Metazoa	T	myosin light chain kinase activity	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	I-set,fn3
MMD1_k127_186934_4	1094980.Mpsy_1961	5.611e-73	253.0	COG0262@1|root,arCOG01490@2157|Archaea,2XYCD@28890|Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
MMD1_k127_186934_2	293826.Amet_1912	1.945e-104	349.0	COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,24BVW@186801|Clostridia,36GH5@31979|Clostridiaceae	186801|Clostridia	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
MMD1_k127_186934_7	1907.SGLAU_00645	9.773e-08	66.0	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14
MMD1_k127_186934_6	373994.Riv7116_1673	7.597e-19	101.0	COG3209@1|root,COG3209@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
MMD1_k127_186934_3	696747.NIES39_L00820	2.37e-88	303.0	COG1064@1|root,COG1064@2|Bacteria,1G0B9@1117|Cyanobacteria,1H851@1150|Oscillatoriales	1117|Cyanobacteria	C	COG1064 Zn-dependent alcohol	-	-	-	ko:K12957	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMD1_k127_186934_5	323259.Mhun_1437	7.098e-25	110.0	COG0328@1|root,arCOG02942@2157|Archaea,2XT22@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0328 Ribonuclease HI	rnhA2	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
MMD1_k127_186934_0	1304284.L21TH_0179	1.247e-220	697.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36HQZ@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
MMD1_k127_186934_1	521011.Mpal_0645	1.038e-104	349.0	COG1741@1|root,arCOG02935@2157|Archaea,2XU8Z@28890|Euryarchaeota,2N95U@224756|Methanomicrobia	224756|Methanomicrobia	S	Pirin	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
MMD1_k127_186934_8	1121957.ATVL01000008_gene4626	0.0001764	46.0	COG1012@1|root,COG1012@2|Bacteria,4NFTW@976|Bacteroidetes,47JZ2@768503|Cytophagia	976|Bacteroidetes	C	TIGRFAM delta-1-pyrroline-5-carboxylate dehydrogenase, group 1	pruA	-	1.2.1.88,1.5.5.2	ko:K00294,ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
MMD1_k127_1873596_0	221288.JH992901_gene680	4.936e-31	138.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1JK6S@1189|Stigonemataceae	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
MMD1_k127_1879309_0	593750.Metfor_2676	1.78e-47	182.0	COG0863@1|root,arCOG00115@2157|Archaea	2157|Archaea	H	methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMD1_k127_1879309_3	391612.CY0110_15537	4.686e-18	100.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1G1I0@1117|Cyanobacteria,3KK8R@43988|Cyanothece	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,Lectin_C
MMD1_k127_1879309_1	1379698.RBG1_1C00001G1047	1.169e-29	126.0	COG1913@1|root,COG1913@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
MMD1_k127_1879309_2	1348583.ATLH01000017_gene2670	1.457e-29	129.0	COG3291@1|root,COG3291@2|Bacteria,4PKJH@976|Bacteroidetes,1IJAY@117743|Flavobacteriia,1FAMT@104264|Cellulophaga	976|Bacteroidetes	E	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Malectin,PKD
MMD1_k127_1883487_1	589924.Ferp_1102	6.554e-10	65.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,246AV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1883487_0	1394178.AWOO02000020_gene7490	1.266e-12	79.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4EHCY@85012|Streptosporangiales	201174|Actinobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
MMD1_k127_1912524_0	485915.Dret_1495	3.956e-102	346.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria,2M8IA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
MMD1_k127_1912524_1	386456.JQKN01000017_gene846	1.554e-58	216.0	COG4832@1|root,arCOG03571@1|root,arCOG03201@2157|Archaea,arCOG03571@2157|Archaea,2Y3NU@28890|Euryarchaeota	28890|Euryarchaeota	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
MMD1_k127_1912524_2	309799.DICTH_1716	1.876e-54	195.0	COG2193@1|root,COG2193@2|Bacteria	2|Bacteria	P	ferroxidase activity	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
MMD1_k127_1912524_3	96561.Dole_0760	1.136e-46	186.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
MMD1_k127_1912524_4	485913.Krac_9072	1.055e-40	162.0	COG3214@1|root,COG3214@2|Bacteria,2G766@200795|Chloroflexi	200795|Chloroflexi	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMD1_k127_1924040_1	868131.MSWAN_1362	1.351e-11	77.0	COG0381@1|root,arCOG01392@2157|Archaea	2157|Archaea	M	UDP-N-acetylglucosamine 2-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1924040_0	1304865.JAGF01000001_gene343	2.034e-25	121.0	COG1216@1|root,COG1216@2|Bacteria,2I67V@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyltransferase, group 2 family protein	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
MMD1_k127_1927715_0	1054217.TALC_01538	5.185e-208	674.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241ID@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMD1_k127_1927715_2	1094980.Mpsy_2342	2.051e-41	171.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMD1_k127_1927715_3	2423.NA23_0205210	1.05e-31	134.0	COG0457@1|root,COG0457@2|Bacteria	2423.NA23_0205210|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1927715_1	439481.Aboo_1385	1.041e-124	445.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,3F30Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
MMD1_k127_1927715_4	1054217.TALC_00146	4.076e-27	116.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,241T6@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
MMD1_k127_1934181_0	1120950.KB892795_gene2309	1.87e-82	282.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4DPCW@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMD1_k127_1943808_2	316274.Haur_1012	8.486e-54	199.0	COG0454@1|root,COG1246@1|root,COG0456@2|Bacteria,COG1246@2|Bacteria,2G8UQ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_1943808_6	436308.Nmar_1073	2.248e-14	85.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
MMD1_k127_1943808_3	1304885.AUEY01000082_gene2157	1.247e-53	199.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,42MSW@68525|delta/epsilon subdivisions,2WNY3@28221|Deltaproteobacteria,2MJ39@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
MMD1_k127_1943808_1	1459636.NTE_02785	7.254e-83	289.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMD1_k127_1943808_4	273116.14325461	1.567e-48	179.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Chromate resistance	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
MMD1_k127_1943808_0	671143.DAMO_0892	1.072e-139	460.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.38	ko:K01371	ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_C1
MMD1_k127_1943808_5	1125971.ASJB01000099_gene2395	6.679e-18	89.0	COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria,4E4VR@85010|Pseudonocardiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMD1_k127_1962963_0	439481.Aboo_0781	1.649e-64	241.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
MMD1_k127_1972213_1	439481.Aboo_0745	5.951e-48	175.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,3F2P5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMD1_k127_1972213_0	673860.AciM339_0318	1.371e-60	219.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,3F2K2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	6,7-dimethyl-8-ribityllumazine synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMD1_k127_1972213_2	673860.AciM339_0317	7.945e-39	153.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,3F2RF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMD1_k127_1972213_3	931277.C448_03886	4.39e-05	46.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,23U03@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
MMD1_k127_1973184_4	521011.Mpal_0492	9.043e-57	207.0	COG1584@1|root,arCOG03176@2157|Archaea,2XWNC@28890|Euryarchaeota,2N9MY@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMD1_k127_1973184_2	290315.Clim_1112	3.133e-95	335.0	COG0190@1|root,COG0190@2|Bacteria,1FE78@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMD1_k127_1973184_1	292459.STH3189	8.081e-208	660.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia	186801|Clostridia	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMD1_k127_1973184_0	370438.PTH_2131	1.834e-289	901.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes,24BRX@186801|Clostridia,260H8@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMD1_k127_1973184_3	246194.CHY_0066	4.691e-93	321.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,42EKW@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
MMD1_k127_1973184_5	8364.ENSXETP00000049432	4.904e-54	215.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,4837Y@7711|Chordata,497BW@7742|Vertebrata	33208|Metazoa	S	inter-alpha-trypsin inhibitor heavy chain	ITIH6	-	-	-	-	-	-	-	-	-	-	-	ITI_HC_C,VIT,VWA,VWA_3
MMD1_k127_1973184_6	9767.XP_007174817.1	8.651e-48	193.0	COG2304@1|root,2QPS2@2759|Eukaryota,38C6V@33154|Opisthokonta,3BE0X@33208|Metazoa,3CW49@33213|Bilateria,4803N@7711|Chordata,4955J@7742|Vertebrata,3JDQS@40674|Mammalia,4J0DB@91561|Cetartiodactyla	33208|Metazoa	T	inter-alpha-trypsin inhibitor heavy chain	ITIH3	GO:0002576,GO:0003674,GO:0004857,GO:0004866,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006887,GO:0008150,GO:0009892,GO:0009987,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0016192,GO:0019222,GO:0030141,GO:0030162,GO:0030234,GO:0030414,GO:0031089,GO:0031323,GO:0031324,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032268,GO:0032269,GO:0032940,GO:0034774,GO:0042827,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0044092,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045861,GO:0046903,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051179,GO:0051234,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060205,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0070013,GO:0080090,GO:0097708,GO:0098772,GO:0099503	-	-	-	-	-	-	-	-	-	-	ITI_HC_C,VIT,VWA
MMD1_k127_1975699_2	693977.Deipr_0951	4.333e-45	183.0	COG4948@1|root,COG4948@2|Bacteria,1WMNA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Mandelate racemase muconate lactonizing enzyme	ykfB	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMD1_k127_1975699_0	1382306.JNIM01000001_gene2829	1.335e-70	252.0	COG3367@1|root,COG3367@2|Bacteria	2|Bacteria	M	COGs COG3367 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N,Peptidase_S8
MMD1_k127_1975699_1	1229203.KI301992_gene132	1.299e-49	192.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,3UWPT@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
MMD1_k127_1975699_3	1150399.AQYK01000002_gene3209	1.43e-34	147.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
MMD1_k127_197597_0	1122223.KB890687_gene2570	1.73e-09	72.0	COG1470@1|root,COG4719@1|root,COG1470@2|Bacteria,COG4719@2|Bacteria,1WJNZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_1997482_1	1070774.J07HN4v3_00095	4.253e-10	72.0	arCOG07655@1|root,arCOG07655@2157|Archaea,2Y71F@28890|Euryarchaeota,23UID@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_1997482_0	264732.Moth_0153	5.042e-11	70.0	COG1142@1|root,COG1142@2|Bacteria,1VH83@1239|Firmicutes,24TVN@186801|Clostridia,42JCX@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_4,Fer4_7
MMD1_k127_1997588_1	246197.MXAN_7458	9.749e-22	112.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	ko:K07114,ko:K07169,ko:K12065	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3,3.A.7.11.1	-	-	-
MMD1_k127_1997588_0	251221.35214774	1.077e-89	331.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
MMD1_k127_2004967_0	1173028.ANKO01000031_gene3928	7.194e-17	91.0	COG1216@1|root,COG3222@1|root,COG1216@2|Bacteria,COG3222@2|Bacteria,1G0X3@1117|Cyanobacteria,1HHXX@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064,Glycos_transf_2
MMD1_k127_2046166_0	243231.GSU2914	2.997e-30	141.0	COG3391@1|root,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria,43C5A@68525|delta/epsilon subdivisions,2WNBK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2048342_3	717605.Theco_1110	4.751e-05	57.0	COG0477@1|root,COG2814@2|Bacteria,1UI43@1239|Firmicutes,4ISCR@91061|Bacilli,26RSR@186822|Paenibacillaceae	91061|Bacilli	EGP	Major facilitator superfamily	yqgE	-	-	ko:K08222	-	-	-	-	ko00000,ko02000	2.A.1.33	-	-	MFS_1
MMD1_k127_2048342_2	1121946.AUAX01000033_gene5680	9.798e-16	89.0	COG0500@1|root,COG2226@2|Bacteria,2I9S2@201174|Actinobacteria,4DC7G@85008|Micromonosporales	201174|Actinobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMD1_k127_2048342_1	1054217.TALC_00422	2.16e-32	140.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,241V4@183967|Thermoplasmata	183967|Thermoplasmata	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
MMD1_k127_2048342_0	926690.KE386573_gene2624	1.643e-57	211.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23SHW@183963|Halobacteria	183963|Halobacteria	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMD1_k127_2049844_1	251221.35211154	1.5e-05	58.0	COG2706@1|root,COG2706@2|Bacteria,1GQSX@1117|Cyanobacteria	1117|Cyanobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	TIG,VCBS
MMD1_k127_2049844_0	279714.FuraDRAFT_1967	6.616e-31	140.0	COG3299@1|root,COG3299@2|Bacteria,1P3E0@1224|Proteobacteria,2VKDQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J,PA14
MMD1_k127_2055792_0	999419.HMPREF1077_00074	7.692e-06	57.0	COG1629@1|root,COG4771@2|Bacteria,4NF05@976|Bacteroidetes,2FMJS@200643|Bacteroidia,22X9C@171551|Porphyromonadaceae	976|Bacteroidetes	P	TonB-dependent receptor	-	-	-	ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14.1,1.B.14.10	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
MMD1_k127_2058784_3	439481.Aboo_0163	2.841e-05	57.0	arCOG08231@1|root,arCOG08231@2157|Archaea	2157|Archaea	L	Micrococcal nuclease (thermonuclease) homologs	-	-	3.1.31.1	ko:K01174,ko:K02238	-	M00429	-	-	ko00000,ko00002,ko01000,ko02044	3.A.11.1,3.A.11.2	-	-	LTD,Lactamase_B,PhoD,SNase
MMD1_k127_2058784_0	1379698.RBG1_1C00001G0936	6.475e-41	161.0	COG1335@1|root,COG1335@2|Bacteria,2NRGH@2323|unclassified Bacteria	2|Bacteria	Q	Isochorismatase family	-	-	3.5.1.110	ko:K09020	ko00240,ko01100,map00240,map01100	-	R09947,R09980	RC02737,RC02738	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
MMD1_k127_2058784_2	1122917.KB899670_gene4285	1.541e-08	69.0	COG3507@1|root,COG5297@1|root,COG3507@2|Bacteria,COG5297@2|Bacteria,1TXPR@1239|Firmicutes,4I6QI@91061|Bacilli,26UAT@186822|Paenibacillaceae	91061|Bacilli	G	Cellulase N-terminal ig-like domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
MMD1_k127_2058784_1	911008.GLAD_01304	4.896e-22	114.0	COG2373@1|root,COG3210@1|root,COG2373@2|Bacteria,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,1T24R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
MMD1_k127_2058784_4	1122129.AUEF01000017_gene82	0.0001502	52.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,4HIG2@91061|Bacilli,4GYYA@90964|Staphylococcaceae	91061|Bacilli	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMD1_k127_2059891_1	1120999.JONM01000012_gene2242	8.163e-11	76.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG2373@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2373@2|Bacteria,COG4733@2|Bacteria,1QV7E@1224|Proteobacteria,2WHIN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD1_k127_2059891_0	762982.HMPREF9442_03088	2.964e-30	139.0	COG1520@1|root,COG4870@1|root,COG1520@2|Bacteria,COG4870@2|Bacteria,4NVQ3@976|Bacteroidetes,2G321@200643|Bacteroidia	976|Bacteroidetes	MO	Peptidase family C25	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25,VCBS
MMD1_k127_2063046_0	1961.JOAK01000018_gene571	5.968e-11	71.0	COG0500@1|root,COG2226@2|Bacteria,2I1M7@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMD1_k127_2063046_1	550540.Fbal_0532	6.726e-08	66.0	COG0824@1|root,COG1470@1|root,COG2885@1|root,COG3637@1|root,COG0824@2|Bacteria,COG1470@2|Bacteria,COG2885@2|Bacteria,COG3637@2|Bacteria,1MX1F@1224|Proteobacteria,1T4AI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMD1_k127_2071665_0	880072.Desac_2889	1.396e-70	247.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	bkdF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMD1_k127_2071665_1	304371.MCP_1721	1.437e-40	160.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0095 Lipoate-protein ligase A	lpl	GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMD1_k127_2090696_3	926550.CLDAP_10550	3.523e-55	207.0	COG0109@1|root,COG0109@2|Bacteria,2G5UC@200795|Chloroflexi	200795|Chloroflexi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
MMD1_k127_2090696_1	251221.35211302	4.6e-150	497.0	COG0843@1|root,COG0843@2|Bacteria	2|Bacteria	C	heme-copper terminal oxidase activity	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
MMD1_k127_2090696_5	1047013.AQSP01000144_gene918	2.67e-29	121.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA	GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042592,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048878,GO:0051186,GO:0051188,GO:0051189,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0090407,GO:0097163,GO:0140104,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.14,2.8.1.7	ko:K00549,ko:K04085,ko:K04487,ko:K08363	ko00270,ko00450,ko00730,ko01100,ko01110,ko01230,ko04122,map00270,map00450,map00730,map01100,map01110,map01230,map04122	M00017	R04405,R07460,R09365,R11528,R11529	RC00035,RC00113,RC01241,RC01789,RC02313	ko00000,ko00001,ko00002,ko01000,ko02000,ko02048,ko03016,ko03029	1.A.72.1	-	-	DUF2249,Rhodanese,TusA
MMD1_k127_2090696_4	1047013.AQSP01000144_gene917	2.139e-46	179.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,DrsE_2
MMD1_k127_2090696_0	1047013.AQSP01000144_gene916	2.404e-157	512.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMD1_k127_2090696_2	1047013.AQSP01000144_gene915	1.835e-81	282.0	COG0492@1|root,COG0822@1|root,COG0492@2|Bacteria,COG0822@2|Bacteria,2NPRS@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_oxidored,FeS_assembly_P,NifU_N,Pyr_redox_2,cNMP_binding
MMD1_k127_2090696_7	323259.Mhun_0530	4.772e-06	53.0	arCOG07677@1|root,arCOG07677@2157|Archaea,2XWVM@28890|Euryarchaeota	28890|Euryarchaeota	S	Possible catecholamine-binding domain present in a variety of eukaryotic proteins.	-	-	-	-	-	-	-	-	-	-	-	-	DOMON
MMD1_k127_2102876_1	696281.Desru_0346	4.379e-10	64.0	COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,2617J@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMD1_k127_2102876_0	1296415.JACC01000020_gene3777	3.934e-16	94.0	COG3291@1|root,COG4412@1|root,COG5297@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,COG5297@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	3.2.1.4	ko:K01179,ko:K20276,ko:K21449	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko02000	1.B.40.2	GH5,GH9	-	CARDB,CBM_2,CBM_3,Glyco_hydro_9,PKD,Peptidase_M30
MMD1_k127_2121008_4	273075.Ta0944m	5.521e-06	58.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,241QC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMD1_k127_2121008_2	502025.Hoch_1849	1.908e-65	237.0	COG1087@1|root,COG1087@2|Bacteria,1R0N8@1224|Proteobacteria,43CYU@68525|delta/epsilon subdivisions,2X870@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMD1_k127_2121008_0	439481.Aboo_1323	1.214e-90	308.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,3F2JQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
MMD1_k127_2121008_1	304371.MCP_1765	6.69e-75	261.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT2Y@28890|Euryarchaeota,2N9GE@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_2121008_3	351160.RCIX2598	2.307e-63	235.0	arCOG04521@1|root,arCOG04521@2157|Archaea,2XUMG@28890|Euryarchaeota,2NAW2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_214152_6	765420.OSCT_1540	0.0003404	53.0	COG0739@1|root,COG3103@1|root,COG0739@2|Bacteria,COG4991@2|Bacteria,2G8N3@200795|Chloroflexi,3757D@32061|Chloroflexia	32061|Chloroflexia	MT	N-Acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_214152_5	195250.CM001776_gene1647	8.323e-08	65.0	COG1572@1|root,COG1864@1|root,COG3209@1|root,COG3210@1|root,COG3291@1|root,COG3386@1|root,COG3391@1|root,COG1572@2|Bacteria,COG1864@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,1GED2@1117|Cyanobacteria,1H2ZS@1129|Synechococcus	1117|Cyanobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_214152_4	237368.SCABRO_01236	2.651e-11	77.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD
MMD1_k127_214152_2	797114.C475_08751	3.292e-48	186.0	COG3359@1|root,arCOG03130@2157|Archaea,2XUES@28890|Euryarchaeota,23SXR@183963|Halobacteria	183963|Halobacteria	L	exonuclease	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
MMD1_k127_214152_3	439481.Aboo_1491	2.061e-15	90.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y0DG@28890|Euryarchaeota,3F2TC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
MMD1_k127_214152_0	673860.AciM339_1459	7.295e-209	663.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2FS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMD1_k127_214152_1	439481.Aboo_1131	1.102e-208	659.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,3F2FS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TCP-1/cpn60 chaperonin family	thsA	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMD1_k127_2144082_0	635013.TherJR_0525	3.284e-284	887.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
MMD1_k127_2144082_1	591019.Shell_0356	9.251e-40	170.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
MMD1_k127_2153640_3	673860.AciM339_0010	3.326e-13	85.0	COG1361@1|root,arCOG01917@1|root,arCOG05791@1|root,arCOG01917@2157|Archaea,arCOG02079@2157|Archaea,arCOG04400@2157|Archaea,arCOG05791@2157|Archaea,2Y1TH@28890|Euryarchaeota,3F2UJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DZR,zinc_ribbon_2
MMD1_k127_2153640_2	1041930.Mtc_0986	5.609e-14	82.0	arCOG02911@1|root,arCOG02911@2157|Archaea,2Y0M6@28890|Euryarchaeota,2N9ZD@224756|Methanomicrobia	224756|Methanomicrobia	U	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2153640_1	1116472.MGMO_57c00190	2.488e-21	109.0	COG0028@1|root,COG3291@1|root,COG0028@2|Bacteria,COG3291@2|Bacteria,1R1H9@1224|Proteobacteria,1T52V@1236|Gammaproteobacteria,1XEUH@135618|Methylococcales	2|Bacteria	EH	Fibronectin type 3 domain	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF5017,DUF5050,Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
MMD1_k127_2153640_5	192952.MM_1507	1.705e-09	70.0	arCOG02914@1|root,arCOG02914@2157|Archaea	2157|Archaea	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2153640_7	1094980.Mpsy_3159	6.036e-05	57.0	COG3291@1|root,arCOG02420@1|root,arCOG02914@1|root,arCOG07813@1|root,arCOG02420@2157|Archaea,arCOG02510@2157|Archaea,arCOG02914@2157|Archaea,arCOG07813@2157|Archaea,2Y6ZU@28890|Euryarchaeota,2NB69@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF1628	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
MMD1_k127_2153640_4	593750.Metfor_0051	2.079e-12	72.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
MMD1_k127_2153640_0	1094980.Mpsy_2683	1.72e-133	449.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
MMD1_k127_2153640_6	419665.Maeo_1064	6.679e-06	61.0	COG3210@1|root,arCOG07534@2157|Archaea,2XVS6@28890|Euryarchaeota,23RVQ@183939|Methanococci	183939|Methanococci	M	toxin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2176481_0	1236689.MMALV_05030	7.034e-75	264.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,3F2P2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMD1_k127_2176481_2	324602.Caur_1236	3.091e-27	129.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
MMD1_k127_2176481_3	579137.Metvu_0969	8.545e-05	51.0	COG1719@1|root,arCOG01688@2157|Archaea,2XY7Q@28890|Euryarchaeota	28890|Euryarchaeota	K	PFAM 4-vinyl reductase, 4VR	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_5,V4R
MMD1_k127_2176481_4	1386089.N865_16940	0.0002075	48.0	COG4430@1|root,COG4430@2|Bacteria,2II0D@201174|Actinobacteria,4FGFM@85021|Intrasporangiaceae	201174|Actinobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
MMD1_k127_2176481_1	304371.MCP_1404	3.981e-53	195.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMD1_k127_2178763_0	673860.AciM339_1526	6.35e-23	108.0	COG3815@1|root,arCOG03949@2157|Archaea,2Y6YC@28890|Euryarchaeota,3F307@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
MMD1_k127_2191801_3	1006000.GKAS_03905	3.799e-09	71.0	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	PFAM FecR protein	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
MMD1_k127_2191801_2	1249627.D779_3142	8.806e-13	83.0	COG4254@1|root,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,FecR,LysM,fn3
MMD1_k127_2191801_1	1049564.TevJSym_ak00210	4.068e-18	95.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1J71R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
MMD1_k127_2191801_5	880073.Calab_1548	5.854e-06	55.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMD1_k127_2191801_0	1071679.BG57_31840	1.255e-30	134.0	COG0454@1|root,COG0454@2|Bacteria,1RIFC@1224|Proteobacteria,2VUWB@28216|Betaproteobacteria,1KG4W@119060|Burkholderiaceae	28216|Betaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
MMD1_k127_2196765_0	443144.GM21_3561	6.101e-32	147.0	COG3209@1|root,COG4932@1|root,COG3209@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_2,CarboxypepD_reg,DUF11,DUF3494,SdrD_B
MMD1_k127_2196765_1	208444.JNYY01000003_gene1974	4.523e-06	62.0	COG4733@1|root,COG4733@2|Bacteria,2I2VQ@201174|Actinobacteria,4DYBB@85010|Pseudonocardiales	201174|Actinobacteria	G	Cellulose binding domain	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,CBM_3,Glyco_hydro_9,fn3
MMD1_k127_2197877_3	584708.Apau_1750	9.867e-36	149.0	COG0169@1|root,COG0169@2|Bacteria,3TB4V@508458|Synergistetes	508458|Synergistetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMD1_k127_2197877_1	1236689.MMALV_04960	2.705e-86	303.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota	28890|Euryarchaeota	E	aspartate-semialdehyde dehydrogenase	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMD1_k127_2197877_0	1121405.dsmv_2622	4.51e-87	305.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42PZ6@68525|delta/epsilon subdivisions,2WKNQ@28221|Deltaproteobacteria,2MI1H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3
MMD1_k127_2197877_2	1094980.Mpsy_2764	1.399e-38	160.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,2N96J@224756|Methanomicrobia	224756|Methanomicrobia	E	shikimate kinase activity	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3127	GHMP_kinases_N
MMD1_k127_2197877_5	935548.KI912159_gene5512	0.0003168	53.0	COG0382@1|root,COG0382@2|Bacteria,1MVS1@1224|Proteobacteria,2TVKN@28211|Alphaproteobacteria,43N6Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	UbiA prenyltransferase family	bchG	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_2197877_4	1123322.KB904650_gene1887	6.684e-10	64.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
MMD1_k127_2198231_2	1267533.KB906733_gene3593	2.975e-56	200.0	COG2185@1|root,COG2185@2|Bacteria,3Y4YE@57723|Acidobacteria,2JMRD@204432|Acidobacteriia	204432|Acidobacteriia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
MMD1_k127_2198231_1	1122221.JHVI01000011_gene943	5.068e-119	391.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMD1_k127_2198231_0	1487921.DP68_00495	7.686e-145	469.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMD1_k127_2198231_3	1267533.KB906740_gene137	2.171e-11	71.0	29Y1S@1|root,30JUQ@2|Bacteria,3Y90C@57723|Acidobacteria,2JNWN@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2210707_1	243231.GSU2073	2.327e-11	76.0	COG3209@1|root,COG3227@1|root,COG3391@1|root,COG3209@2|Bacteria,COG3227@2|Bacteria,COG3391@2|Bacteria,1QW4H@1224|Proteobacteria	1224|Proteobacteria	M	Rhs Family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Autotransporter,Big_3_2,Big_3_5,DUF4082,DUF4347,He_PIG,PT-HINT,RHS_repeat
MMD1_k127_2210707_0	1054217.TALC_01148	2.477e-93	327.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,241NZ@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMD1_k127_2210707_2	273075.Ta1416	2.39e-09	62.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,241XD@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
MMD1_k127_2210707_3	1121129.KB903368_gene857	0.0004279	53.0	COG1305@1|root,COG1305@2|Bacteria,4NFR8@976|Bacteroidetes,2FPAP@200643|Bacteroidia,22W3W@171551|Porphyromonadaceae	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
MMD1_k127_2213071_1	215358.XP_010745133.1	3.288e-29	138.0	KOG0613@1|root,KOG4475@1|root,KOG0613@2759|Eukaryota,KOG4475@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria,484DC@7711|Chordata,49AJ4@7742|Vertebrata	33208|Metazoa	T	Immunoglobulin like	TTN	GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0001701,GO:0001756,GO:0001932,GO:0002020,GO:0002576,GO:0002791,GO:0002793,GO:0003002,GO:0003007,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003300,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0004713,GO:0005198,GO:0005200,GO:0005488,GO:0005509,GO:0005515,GO:0005516,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005829,GO:0005856,GO:0005859,GO:0005865,GO:0006323,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006928,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007059,GO:0007076,GO:0007154,GO:0007165,GO:0007275,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007512,GO:0007517,GO:0008015,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009893,GO:0009952,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010737,GO:0010927,GO:0014706,GO:0014866,GO:0014896,GO:0014897,GO:0015629,GO:0016043,GO:0016192,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0021591,GO:0022402,GO:0022607,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030048,GO:0030049,GO:0030154,GO:0030239,GO:0030240,GO:0030241,GO:0030261,GO:0030506,GO:0031032,GO:0031033,GO:0031034,GO:0031323,GO:0031399,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032991,GO:0033058,GO:0033275,GO:0034622,GO:0035051,GO:0035265,GO:0035282,GO:0035556,GO:0035994,GO:0035995,GO:0036211,GO:0036379,GO:0040007,GO:0040011,GO:0042221,GO:0042325,GO:0042692,GO:0042802,GO:0042805,GO:0043009,GO:0043056,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0043549,GO:0043621,GO:0043933,GO:0044057,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045055,GO:0045214,GO:0045859,GO:0046872,GO:0046903,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048644,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048739,GO:0048747,GO:0048769,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050982,GO:0051015,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051146,GO:0051171,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051246,GO:0051276,GO:0051338,GO:0051371,GO:0051393,GO:0051592,GO:0051606,GO:0051716,GO:0055001,GO:0055002,GO:0055003,GO:0055006,GO:0055007,GO:0055008,GO:0055013,GO:0060047,GO:0060048,GO:0060255,GO:0060322,GO:0060415,GO:0060419,GO:0060429,GO:0060537,GO:0061053,GO:0061061,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070201,GO:0070252,GO:0070925,GO:0071103,GO:0071688,GO:0071704,GO:0071840,GO:0072359,GO:0080090,GO:0090087,GO:0090257,GO:0097435,GO:0097493,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0140014,GO:0140096,GO:1901077,GO:1901564,GO:1901897,GO:1903047,GO:1903530,GO:1903532,GO:1904951	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	I-set,Ig_2,Ig_3,PPAK,Pkinase,Titin_Z,fn3,ig
MMD1_k127_2213071_0	717606.PaecuDRAFT_2033	3.164e-74	286.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_2223235_1	216432.CA2559_13653	1.616e-10	75.0	COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,4NG16@976|Bacteroidetes,1HY10@117743|Flavobacteriia	976|Bacteroidetes	M	C-terminal domain of CHU protein family	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SdrD_B
MMD1_k127_2223235_2	439481.Aboo_0311	0.0004584	53.0	arCOG05366@1|root,arCOG05366@2157|Archaea,2Y703@28890|Euryarchaeota,3F31Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
MMD1_k127_2223235_0	1054217.TALC_01501	2.057e-37	149.0	COG0560@1|root,arCOG01158@2157|Archaea,2Y79H@28890|Euryarchaeota,241UM@183967|Thermoplasmata	183967|Thermoplasmata	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
MMD1_k127_2228711_4	1394178.AWOO02000017_gene6778	8.238e-05	49.0	COG0697@1|root,COG0697@2|Bacteria,2HHVP@201174|Actinobacteria	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMD1_k127_2228711_1	292459.STH775	4.889e-82	287.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia	186801|Clostridia	E	PFAM metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
MMD1_k127_2228711_0	926569.ANT_30560	7.298e-144	474.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMD1_k127_2228711_2	926690.KE386573_gene2094	5.366e-78	278.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,23STJ@183963|Halobacteria	183963|Halobacteria	I	COG0183 Acetyl-CoA acetyltransferase	acaB1	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMD1_k127_2228711_3	246200.SPOA0128	1.016e-08	68.0	COG1545@1|root,COG4221@1|root,COG1545@2|Bacteria,COG4221@2|Bacteria,1QUX5@1224|Proteobacteria,2TXDK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc,adh_short
MMD1_k127_2251476_0	404589.Anae109_3548	3.607e-77	295.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,1REF1@1224|Proteobacteria,42RS0@68525|delta/epsilon subdivisions,2WNDK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
MMD1_k127_2253847_8	1278309.KB907108_gene1558	1.327e-20	109.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria	1224|Proteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
MMD1_k127_2253847_11	1440053.JOEI01000004_gene3860	4.947e-11	77.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C
MMD1_k127_2253847_7	335543.Sfum_0444	7.547e-23	114.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria,42VJ7@68525|delta/epsilon subdivisions,2WS0Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
MMD1_k127_2253847_10	926690.KE386573_gene1542	1.856e-19	102.0	COG0500@1|root,arCOG04583@2157|Archaea,2XTVC@28890|Euryarchaeota,23ST5@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMD1_k127_2253847_5	386456.JQKN01000019_gene1317	4.159e-63	224.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23NYV@183925|Methanobacteria	183925|Methanobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMD1_k127_2253847_0	673860.AciM339_0926	2.111e-259	814.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,3F2GJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	KH domain	epf2	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
MMD1_k127_2253847_1	673860.AciM339_0566	2.137e-107	368.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,3F2ET@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMD1_k127_2253847_3	673860.AciM339_0537	4.12e-98	340.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,3F2FB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
MMD1_k127_2253847_2	439481.Aboo_0417	1.397e-102	344.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,3F2F2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMD1_k127_2253847_6	1122221.JHVI01000012_gene817	6.844e-57	206.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	natA2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_2253847_9	1236689.MMALV_02100	9.107e-20	100.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,3F2SW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	PIN domain of ribonuclease	nob1	GO:0000469,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0030490,GO:0030684,GO:0030688,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1990904	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
MMD1_k127_2253847_4	351627.Csac_0005	1.271e-91	308.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,42EPA@68295|Thermoanaerobacterales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMD1_k127_2255811_1	867845.KI911784_gene2719	2.111e-41	177.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
MMD1_k127_2255811_2	59374.Fisuc_0063	9.346e-14	86.0	COG2911@1|root,COG4254@1|root,COG2911@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	lgt	-	-	ko:K09800,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000	-	-	-	FecR
MMD1_k127_2255811_0	941824.TCEL_01313	2.945e-42	159.0	COG0350@1|root,COG0350@2|Bacteria,1VA03@1239|Firmicutes,24JAA@186801|Clostridia,36JKF@31979|Clostridiaceae	186801|Clostridia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
MMD1_k127_2275671_4	673860.AciM339_1115	1.285e-36	145.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,3F2PV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL32 family	rpl32e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L32e
MMD1_k127_2275671_3	673860.AciM339_1116	4.286e-41	168.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,3F2Q2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl19e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
MMD1_k127_2275671_1	387631.Asulf_00109	3.218e-47	175.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,2463G@183980|Archaeoglobi	183980|Archaeoglobi	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
MMD1_k127_2275671_0	1236689.MMALV_14060	2.4e-85	296.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,3F2HF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMD1_k127_2275671_2	1041930.Mtc_1344	9.47e-45	173.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2N9JA@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM ribosomal protein L30P	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMD1_k127_2275671_5	273116.14324566	3.648e-18	94.0	COG0200@1|root,arCOG00779@2157|Archaea,2Y6A4@28890|Euryarchaeota,241UA@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMD1_k127_2279202_6	1254432.SCE1572_38245	1.761e-59	235.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1P2CI@1224|Proteobacteria	1224|Proteobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
MMD1_k127_2279202_8	186497.PF0315	4.492e-49	183.0	COG1772@1|root,arCOG04364@2157|Archaea,2XXJ6@28890|Euryarchaeota,243JJ@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF531)	-	-	-	ko:K09725	-	-	-	-	ko00000	-	-	-	DUF531
MMD1_k127_2279202_4	666510.ASAC_0809	1.999e-87	302.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
MMD1_k127_2279202_1	633148.Tagg_1095	2.934e-131	432.0	COG0156@1|root,arCOG00113@2157|Archaea,2XPNA@28889|Crenarchaeota	28889|Crenarchaeota	H	pyridoxal phosphate-dependent acyltransferase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMD1_k127_2279202_12	523850.TON_1189	1.13e-17	91.0	COG1681@1|root,arCOG01829@2157|Archaea,2XTEE@28890|Euryarchaeota,242UN@183968|Thermococci	183968|Thermococci	N	Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella	flaB1	GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K07325	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
MMD1_k127_2279202_11	439481.Aboo_0143	3.472e-18	97.0	COG3351@1|root,arCOG02964@2157|Archaea,2XVP0@28890|Euryarchaeota,3F2YQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Flagella accessory protein C (FlaC)	flaD	-	-	ko:K07327,ko:K07328	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_fla_DE,FlaC_arch
MMD1_k127_2279202_14	1455608.JDTH01000002_gene293	3.264e-12	72.0	COG3353@1|root,arCOG01824@2157|Archaea,2XYQP@28890|Euryarchaeota,23WWZ@183963|Halobacteria	183963|Halobacteria	N	archaeal flagellar protein F	flaF	-	-	ko:K07329	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
MMD1_k127_2279202_15	519442.Huta_0958	1.25e-10	68.0	COG3354@1|root,arCOG01822@2157|Archaea,2XYG6@28890|Euryarchaeota,23X1I@183963|Halobacteria	183963|Halobacteria	N	archaeal flagellar protein G	flaG	-	-	ko:K07330	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
MMD1_k127_2279202_7	1094980.Mpsy_2349	2.653e-59	213.0	COG2874@1|root,arCOG04148@2157|Archaea,2XUMD@28890|Euryarchaeota,2N9IB@224756|Methanomicrobia	224756|Methanomicrobia	N	KaiC	-	-	-	ko:K07331	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	ATPase
MMD1_k127_2279202_0	573063.Metin_1102	5.697e-184	590.0	COG4962@1|root,arCOG01817@2157|Archaea,2XTDM@28890|Euryarchaeota,23Q0D@183939|Methanococci	183939|Methanococci	N	PFAM Type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMD1_k127_2279202_2	1094980.Mpsy_2351	2.035e-92	320.0	COG1955@1|root,arCOG01809@2157|Archaea,2XTAX@28890|Euryarchaeota,2N9WG@224756|Methanomicrobia	224756|Methanomicrobia	N	type II secretion system protein	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD1_k127_2279202_3	1236689.MMALV_01920	7.893e-88	300.0	COG1571@1|root,arCOG01116@2157|Archaea,2XTUY@28890|Euryarchaeota	28890|Euryarchaeota	S	methanogenesis marker protein 11	-	-	-	-	-	-	-	-	-	-	-	-	DUF1743
MMD1_k127_2279202_5	589924.Ferp_0959	2.646e-71	254.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,245Z6@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
MMD1_k127_2279202_13	926550.CLDAP_01410	1.328e-12	78.0	COG4328@1|root,COG4328@2|Bacteria,2G8YN@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
MMD1_k127_2279202_10	1396.DJ87_4816	3.073e-20	105.0	COG0490@1|root,COG0490@2|Bacteria,1V4YV@1239|Firmicutes,4IRH1@91061|Bacilli,1ZRUD@1386|Bacillus	91061|Bacilli	P	TrkA-C domain	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
MMD1_k127_2279202_9	1523503.JPMY01000010_gene2552	3.967e-31	139.0	COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,1T1GS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0475 Kef-type K transport systems, membrane components	IV02_22945	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
MMD1_k127_2295498_3	443144.GM21_2451	2.587e-06	61.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,fn3
MMD1_k127_2295498_4	240016.ABIZ01000001_gene2892	9.292e-05	56.0	COG4409@1|root,COG4409@2|Bacteria,46V4S@74201|Verrucomicrobia,2IWB9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
MMD1_k127_2295498_2	316067.Geob_0814	2.324e-06	59.0	COG1361@1|root,COG1520@1|root,COG1657@1|root,COG4257@1|root,COG4733@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG1657@2|Bacteria,COG4257@2|Bacteria,COG4733@2|Bacteria,1QYWJ@1224|Proteobacteria,43CDC@68525|delta/epsilon subdivisions,2X7P6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_2295498_1	1041930.Mtc_1304	1.204e-61	239.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,2N9Z2@224756|Methanomicrobia	224756|Methanomicrobia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMD1_k127_2295498_0	351160.RRC440	1.833e-142	464.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2NADJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF650	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMD1_k127_2300333_1	439481.Aboo_0770	1.946e-65	252.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,3F2M3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMD1_k127_2300333_2	1236689.MMALV_02570	1.278e-33	142.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,3F2N5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	UbiA prenyltransferase family	ubiA	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMD1_k127_2300333_0	264732.Moth_0268	3.227e-70	248.0	COG1801@1|root,COG1801@2|Bacteria,1TPX4@1239|Firmicutes,24F1Y@186801|Clostridia,42G35@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMD1_k127_2306890_0	1459636.NTE_00826	3.916e-31	135.0	COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
MMD1_k127_2317582_0	717606.PaecuDRAFT_2136	3.747e-35	156.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
MMD1_k127_2317582_1	1476876.JOJO01000029_gene3524	2.243e-16	93.0	COG0454@1|root,COG0454@2|Bacteria,2GMUB@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_2317582_2	453591.Igni_0753	3.469e-09	69.0	arCOG06454@1|root,arCOG06454@2157|Archaea	2157|Archaea	S	Zc3h12a-like Ribonuclease NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	RNase_Zc3h12a
MMD1_k127_2317582_3	204669.Acid345_1092	8.421e-05	55.0	2DBVP@1|root,2ZBCI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2346775_0	439481.Aboo_0197	5.475e-268	858.0	COG0640@1|root,COG1201@1|root,arCOG00394@2157|Archaea,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,3F2IQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DEAD/H associated	lhr2	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMD1_k127_2349571_0	1123508.JH636439_gene346	8.909e-34	155.0	COG2706@1|root,COG3210@1|root,COG3391@1|root,COG4932@1|root,COG2706@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2IY8U@203682|Planctomycetes	203682|Planctomycetes	M	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_2349571_1	344747.PM8797T_18439	3.333e-08	70.0	COG1657@1|root,COG1657@2|Bacteria,2IZ5Q@203682|Planctomycetes	203682|Planctomycetes	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
MMD1_k127_2356087_1	760568.Desku_1478	1.046e-114	381.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia	186801|Clostridia	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
MMD1_k127_2356087_3	1054217.TALC_00333	1.347e-62	218.0	COG1908@1|root,arCOG02475@2157|Archaea,2XY1E@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	mvhD-2	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
MMD1_k127_2356087_6	335543.Sfum_1975	9.576e-06	56.0	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,FlpD,HTH_5
MMD1_k127_2356087_2	1121422.AUMW01000038_gene3024	2.528e-107	366.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia,264VD@186807|Peptococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
MMD1_k127_2356087_0	1379698.RBG1_1C00001G0047	6.251e-183	585.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
MMD1_k127_2356087_4	1236689.MMALV_13670	4.884e-49	180.0	COG2048@1|root,arCOG00964@2157|Archaea,2XZ7E@28890|Euryarchaeota,3F2WA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD1_k127_2356087_5	1054217.TALC_01276	2.178e-06	49.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,242CE@183967|Thermoplasmata	183967|Thermoplasmata	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00241,ko:K03389	ko00020,ko00190,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00356,M00357,M00374,M00376,M00563,M00567	R02164,R04540,R11928,R11931,R11943,R11944	RC00011,RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_2363339_1	1121405.dsmv_0737	3.105e-11	77.0	COG1649@1|root,COG2133@1|root,COG2755@1|root,COG3023@1|root,COG3250@1|root,COG3291@1|root,COG1649@2|Bacteria,COG2133@2|Bacteria,COG2755@2|Bacteria,COG3023@2|Bacteria,COG3250@2|Bacteria,COG3291@2|Bacteria,1R2HQ@1224|Proteobacteria,42ZN7@68525|delta/epsilon subdivisions,2WUV4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	PFAM Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
MMD1_k127_2363339_0	459349.CLOAM0437	5.266e-84	308.0	COG0457@1|root,COG0457@2|Bacteria	459349.CLOAM0437|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2364313_4	643648.Slip_0329	0.0001356	48.0	COG0619@1|root,COG0619@2|Bacteria,1TSB5@1239|Firmicutes,24AN7@186801|Clostridia,42KJH@68298|Syntrophomonadaceae	186801|Clostridia	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
MMD1_k127_2364313_0	1121468.AUBR01000037_gene1350	6.402e-110	379.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia	186801|Clostridia	P	Abc transporter	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
MMD1_k127_2364313_2	635013.TherJR_1260	2.32e-43	178.0	COG4720@1|root,COG4720@2|Bacteria,1V2DR@1239|Firmicutes,249XR@186801|Clostridia,25ZZ6@186807|Peptococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF-ribofla_trS,ECF_trnsprt
MMD1_k127_2364313_1	877455.Metbo_0697	4.689e-48	189.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD1_k127_2364313_3	868131.MSWAN_1557	8.618e-14	75.0	COG0842@1|root,arCOG01463@2157|Archaea,2Y34U@28890|Euryarchaeota,23PDD@183925|Methanobacteria	183925|Methanobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD1_k127_2370338_0	1041930.Mtc_1630	2.963e-48	194.0	COG2202@1|root,arCOG02353@1|root,arCOG02353@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMD1_k127_2370338_1	765913.ThidrDRAFT_2969	1.762e-10	74.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1WXIU@135613|Chromatiales	135613|Chromatiales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
MMD1_k127_2388928_4	368407.Memar_0278	1.619e-10	71.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD1_k127_2388928_1	1041930.Mtc_1925	3.685e-100	351.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD1_k127_2388928_3	351160.LRC375	1.702e-13	80.0	arCOG02346@1|root,arCOG03799@1|root,arCOG06940@1|root,arCOG02346@2157|Archaea,arCOG03799@2157|Archaea,arCOG06940@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Anticodon_1,DUF835,GAF_2,GAF_3,HAMP,HATPase_c,PAS,PAS_3,PAS_9,Response_reg,zinc_ribbon_2
MMD1_k127_2388928_6	368407.Memar_2171	2.512e-08	63.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,2NBE1@224756|Methanomicrobia	224756|Methanomicrobia	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4
MMD1_k127_2388928_5	523850.TON_1346	9.617e-10	66.0	COG1931@1|root,arCOG01043@2157|Archaea,2Y0M1@28890|Euryarchaeota,2440X@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
MMD1_k127_2388928_0	342949.PNA2_1352	3.601e-196	636.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,242P8@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
MMD1_k127_2388928_2	1041930.Mtc_0652	7.41e-29	121.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2N9RM@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM cytidyltransferase-related domain	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
MMD1_k127_2388928_7	673860.AciM339_0110	1.623e-06	52.0	COG4068@1|root,arCOG04390@2157|Archaea,2Y19A@28890|Euryarchaeota,3F3EH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized protein containing a Zn-ribbon (DUF2116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
MMD1_k127_2408457_4	715451.ambt_18990	0.0003279	55.0	COG1361@1|root,COG5276@1|root,COG1361@2|Bacteria,COG5276@2|Bacteria,1R1M7@1224|Proteobacteria,1T559@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2408457_0	521011.Mpal_0225	4.628e-264	848.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD1_k127_2408457_2	243365.CV_3216	4.545e-25	117.0	COG2020@1|root,COG2020@2|Bacteria,1MUBZ@1224|Proteobacteria,2VJJ4@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
MMD1_k127_2408457_3	1120999.JONM01000012_gene2242	1.939e-18	102.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG2373@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2373@2|Bacteria,COG4733@2|Bacteria,1QV7E@1224|Proteobacteria,2WHIN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD1_k127_2408457_1	521011.Mpal_1221	6.896e-72	249.0	COG1992@1|root,arCOG00021@2157|Archaea,2Y3P5@28890|Euryarchaeota,2NAWT@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine-phosphate synthase	-	-	2.5.1.3	ko:K21220	ko00730,ko01100,map00730,map01100	-	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	ThiP_synth
MMD1_k127_2434122_0	2074.JNYD01000012_gene330	0.0004068	53.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4E42K@85010|Pseudonocardiales	201174|Actinobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMD1_k127_2434419_2	682795.AciX8_1500	3.47e-10	66.0	COG0110@1|root,COG1086@1|root,COG0110@2|Bacteria,COG1086@2|Bacteria	2|Bacteria	GM	Polysaccharide biosynthesis protein	pseB	-	2.3.1.203,4.2.1.115	ko:K13006,ko:K15673,ko:K15894,ko:K15913,ko:K19429	ko00520,ko01051,ko01052,map00520,map01051,map01052	-	R09697,R10099	RC00004,RC00166,RC02609	ko00000,ko00001,ko01000,ko01005,ko01008	-	-	-	Hexapep,Polysacc_synt_2
MMD1_k127_2434419_0	386415.NT01CX_1785	6.803e-90	313.0	COG0381@1|root,COG0381@2|Bacteria,1TQKQ@1239|Firmicutes,24A0H@186801|Clostridia,36FX5@31979|Clostridiaceae	186801|Clostridia	M	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing	neuC	-	3.2.1.183,3.2.1.184	ko:K08068,ko:K18429	ko00520,map00520	-	R10187	RC00005,RC00288	ko00000,ko00001,ko01000	-	-	-	Epimerase_2
MMD1_k127_2434419_1	1347368.HG964403_gene4490	7.145e-16	92.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMD1_k127_24394_0	1123278.KB893387_gene4337	2.964e-22	113.0	COG2755@1|root,COG3391@1|root,COG2755@2|Bacteria,COG3391@2|Bacteria,4PI0M@976|Bacteroidetes,47R8B@768503|Cytophagia	976|Bacteroidetes	E	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_2444235_3	1112216.JH594425_gene1244	2.562e-14	87.0	COG2911@1|root,COG2931@1|root,COG2982@1|root,COG3637@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3637@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2K0IP@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,He_PIG,HemolysinCabind
MMD1_k127_2444235_2	273075.Ta0352	1.271e-25	124.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y7AV@28890|Euryarchaeota,2427M@183967|Thermoplasmata	183967|Thermoplasmata	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMD1_k127_2444235_1	273075.Ta0351	3.385e-110	373.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMD1_k127_2444235_0	671143.DAMO_1208	1.435e-131	424.0	COG0365@1|root,COG0365@2|Bacteria,2NNSQ@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMD1_k127_2453334_0	673860.AciM339_1497	0.0	1040.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,3F2HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
MMD1_k127_2463702_1	273116.14324255	1.565e-05	51.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y4MS@28890|Euryarchaeota,242C9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2463702_0	439481.Aboo_1325	3.067e-20	97.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,3F2RP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5
MMD1_k127_246718_12	926560.KE387023_gene1413	2.203e-06	59.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
MMD1_k127_246718_2	269797.Mbar_A2751	9.601e-69	260.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2Y6XK@28890|Euryarchaeota,2NAMP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_246718_3	192952.MM_1677	4.004e-68	255.0	COG5513@1|root,arCOG02527@1|root,arCOG02540@1|root,arCOG02527@2157|Archaea,arCOG02540@2157|Archaea,arCOG03544@2157|Archaea,2Y7NH@28890|Euryarchaeota	28890|Euryarchaeota	S	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,PKD
MMD1_k127_246718_1	485913.Krac_1029	9.03e-77	267.0	COG4912@1|root,COG4912@2|Bacteria,2G8BT@200795|Chloroflexi	200795|Chloroflexi	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
MMD1_k127_246718_0	1232410.KI421421_gene3792	2.706e-79	274.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,42WI7@68525|delta/epsilon subdivisions,2WSAF@28221|Deltaproteobacteria,43VM2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
MMD1_k127_246718_7	706587.Desti_1347	1.569e-23	105.0	2DMZP@1|root,32UMQ@2|Bacteria,1N3K9@1224|Proteobacteria,42UFA@68525|delta/epsilon subdivisions,2WQ9Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
MMD1_k127_246718_10	1297742.A176_00747	5.878e-12	78.0	COG1372@1|root,COG2911@1|root,COG3209@1|root,COG1372@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,1PEID@1224|Proteobacteria,438II@68525|delta/epsilon subdivisions,2X3TD@28221|Deltaproteobacteria,2YX2B@29|Myxococcales	28221|Deltaproteobacteria	LM	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_246718_4	415426.Hbut_1592	4.596e-42	164.0	COG1756@1|root,arCOG04122@2157|Archaea,2XQJ6@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
MMD1_k127_246718_8	1033730.CAHG01000007_gene2687	9.872e-17	84.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DNEX@85009|Propionibacteriales	201174|Actinobacteria	V	COG1136 ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_246718_5	880072.Desac_0390	1.469e-38	157.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,42VVN@68525|delta/epsilon subdivisions,2WRTH@28221|Deltaproteobacteria,2MS9X@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
MMD1_k127_246718_6	1122915.AUGY01000042_gene724	1.14e-30	126.0	COG4186@1|root,COG4186@2|Bacteria,1V6DG@1239|Firmicutes,4HPXG@91061|Bacilli,26VH5@186822|Paenibacillaceae	91061|Bacilli	S	Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
MMD1_k127_246718_11	1111135.HMPREF1248_0562	6.882e-11	73.0	COG2253@1|root,COG2253@2|Bacteria,2HVQP@201174|Actinobacteria,4CXA3@84998|Coriobacteriia	84998|Coriobacteriia	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
MMD1_k127_246718_9	545696.HOLDEFILI_00100	9.213e-16	87.0	COG5340@1|root,COG5340@2|Bacteria,1V8RR@1239|Firmicutes	1239|Firmicutes	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1
MMD1_k127_2473564_4	1151117.AJLF01000001_gene954	2.064e-15	83.0	COG2306@1|root,arCOG05760@2157|Archaea,2XX0W@28890|Euryarchaeota,243ZF@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF402)	-	-	-	ko:K09145	-	-	-	-	ko00000	-	-	-	DUF402
MMD1_k127_2473564_1	1347368.HG964403_gene4490	2.124e-56	227.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMD1_k127_2473564_3	525904.Tter_2098	7.551e-16	93.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9,fn3
MMD1_k127_2473564_5	1145276.T479_09050	2.185e-09	72.0	COG1361@1|root,COG3210@1|root,COG5492@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1VBWG@1239|Firmicutes,4ITWA@91061|Bacilli,3IZ5A@400634|Lysinibacillus	91061|Bacilli	MN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,Cadherin_3,Flg_new,SLH
MMD1_k127_2473564_0	1054217.TALC_01079	1.214e-280	889.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,241KT@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD1_k127_2473564_2	351160.RCIX288	8.808e-36	142.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,2N9BT@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMD1_k127_2486660_2	273116.14324569	4.854e-26	116.0	COG1422@1|root,arCOG02673@2157|Archaea,2XZDK@28890|Euryarchaeota,241UY@183967|Thermoplasmata	183967|Thermoplasmata	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
MMD1_k127_2486660_1	1261545.MBE-HAL_1900	8.879e-38	157.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,23SWN@183963|Halobacteria	183963|Halobacteria	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMD1_k127_2486660_0	192952.MM_2154	5.422e-86	302.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
MMD1_k127_2490934_0	383372.Rcas_3601	2.505e-08	68.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	-	-	-	-	-	-	-	-	-	Collagen,DUF389,PG_binding_1
MMD1_k127_2490934_1	998674.ATTE01000001_gene2066	1.574e-06	62.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,TPR_12,TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
MMD1_k127_2493561_12	547559.Nmag_1002	0.0003229	52.0	COG0382@1|root,arCOG00478@2157|Archaea,2XTA4@28890|Euryarchaeota,23S8A@183963|Halobacteria	183963|Halobacteria	H	COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases	lye	-	-	ko:K20616	-	-	-	-	ko00000	-	-	-	UbiA
MMD1_k127_2493561_13	123214.PERMA_1467	0.0007249	51.0	COG0382@1|root,COG0382@2|Bacteria,2G3WY@200783|Aquificae	200783|Aquificae	H	4-hydroxybenzoate polyprenyltransferase	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_2493561_0	1128421.JAGA01000002_gene371	5.657e-185	601.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
MMD1_k127_2493561_7	1041930.Mtc_1491	9.278e-65	253.0	COG0857@1|root,arCOG00099@2157|Archaea,2XU0G@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0857 BioD-like N-terminal domain of phosphotransacetylase	cbiA1	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
MMD1_k127_2493561_4	589924.Ferp_1510	3.209e-94	317.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,246K3@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMD1_k127_2493561_6	69014.TK1611	8.332e-65	231.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,243FU@183968|Thermococci	183968|Thermococci	S	TatD related DNase	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
MMD1_k127_2493561_11	519442.Huta_2910	2.366e-08	66.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWHT@28890|Euryarchaeota,23V64@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5,MarR_2
MMD1_k127_2493561_3	673860.AciM339_0043	2.557e-98	331.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,3F2F3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMD1_k127_2493561_2	340099.Teth39_0216	1.024e-112	381.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMD1_k127_2493561_5	1192034.CAP_5621	6.154e-67	260.0	COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1P2CI@1224|Proteobacteria	1224|Proteobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
MMD1_k127_2493561_8	404589.Anae109_2163	5.846e-56	210.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD1_k127_2493561_10	439481.Aboo_1118	3.302e-17	90.0	COG1412@1|root,arCOG04312@2157|Archaea,2Y0D4@28890|Euryarchaeota,3F2SM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	PIN
MMD1_k127_2493561_1	673860.AciM339_0273	1.051e-168	538.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,3F2I7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
MMD1_k127_2493561_9	673860.AciM339_0274	5.734e-35	138.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,3F2RJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMD1_k127_2513906_0	673860.AciM339_0753	3.889e-216	728.0	COG1287@1|root,arCOG02044@2157|Archaea,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,3F2NE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Carboxypeptidase regulatory-like domain	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	CarboxypepD_reg,PMT_2,STT3
MMD1_k127_2513906_1	882.DVU_0283	4.834e-85	294.0	COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1MV15@1224|Proteobacteria,43BCX@68525|delta/epsilon subdivisions,2X6RU@28221|Deltaproteobacteria,2MH5X@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	Thioredoxin domain	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
MMD1_k127_2513959_2	269799.Gmet_2743	7.893e-06	57.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Kelch_4,Kelch_6,Peptidase_S8,TIG
MMD1_k127_2513959_1	593750.Metfor_0376	4.756e-08	64.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD1_k127_2513959_0	251221.35214822	5.77e-87	316.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,VCBS
MMD1_k127_2522173_1	926550.CLDAP_24080	2.048e-14	81.0	COG0739@1|root,COG0739@2|Bacteria,2G8J0@200795|Chloroflexi	200795|Chloroflexi	M	Bacterial pre-peptidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PPC,Peptidase_M23
MMD1_k127_2522173_0	1347368.HG964403_gene4490	1.732e-64	253.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMD1_k127_2536180_3	439481.Aboo_1545	4.864e-55	202.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y4JI@28890|Euryarchaeota,3F328@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_2536180_8	246969.TAM4_1610	1.141e-05	57.0	arCOG03797@1|root,arCOG03797@2157|Archaea,2Y3GC@28890|Euryarchaeota,2444Z@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF835
MMD1_k127_2536180_2	1151117.AJLF01000002_gene499	1.611e-69	243.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMD1_k127_2536180_7	673860.AciM339_0534	5.944e-06	57.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y10D@28890|Euryarchaeota,3F34Z@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	ribosomal small subunit binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2536180_1	673860.AciM339_0533	2.784e-80	296.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,3F2HM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMD1_k127_2536180_4	1236689.MMALV_14300	1.386e-42	168.0	arCOG04990@1|root,arCOG04990@2157|Archaea,2XYVI@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function TPD sequence-motif	-	-	-	-	-	-	-	-	-	-	-	-	TPD
MMD1_k127_2536180_6	439481.Aboo_0139	1.325e-07	64.0	COG4906@1|root,arCOG00568@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2206
MMD1_k127_2536180_0	1236689.MMALV_00330	3.352e-169	535.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,3F2FH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMD1_k127_2536180_5	118173.KB235914_gene1471	4.205e-28	130.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria,1HAPX@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS
MMD1_k127_2582563_0	443254.Marpi_0767	1.432e-09	72.0	COG5276@1|root,COG5276@2|Bacteria,2GD6R@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin, type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2582563_1	760568.Desku_2763	6.032e-06	54.0	COG3005@1|root,COG3005@2|Bacteria,1VEVM@1239|Firmicutes,24RTH@186801|Clostridia,26329@186807|Peptococcaceae	186801|Clostridia	C	PFAM NapC NirT cytochrome c	-	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
MMD1_k127_2600559_2	666510.ASAC_0809	5.288e-85	297.0	COG3199@1|root,arCOG01350@2157|Archaea,2XPMG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATP-NAD AcoX kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
MMD1_k127_2600559_1	634498.mru_2159	4.024e-139	457.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,23PBY@183925|Methanobacteria	183925|Methanobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMD1_k127_2600559_0	869210.Marky_1642	2.981e-175	561.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
MMD1_k127_2600559_3	1535422.ND16A_1818	3.843e-26	127.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,1RWN2@1236|Gammaproteobacteria,2Q85J@267889|Colwelliaceae	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMD1_k127_2607626_2	1454007.JAUG01000055_gene3325	2.574e-18	97.0	COG2373@1|root,COG3209@1|root,COG4547@1|root,COG5384@1|root,COG2373@2|Bacteria,COG3209@2|Bacteria,COG4547@2|Bacteria,COG5384@2|Bacteria,4PKBQ@976|Bacteroidetes,1J0N1@117747|Sphingobacteriia	976|Bacteroidetes	M	conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,SprB
MMD1_k127_2607626_0	439481.Aboo_1207	1.37e-82	294.0	COG1672@1|root,arCOG03166@2157|Archaea,2XYI6@28890|Euryarchaeota	28890|Euryarchaeota	S	ATPase, AAA superfamily	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_14
MMD1_k127_2607626_1	880073.Calab_0526	4.874e-21	109.0	COG1404@1|root,COG3291@1|root,COG3386@1|root,COG5276@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17,3.2.1.4	ko:K01053,ko:K01179,ko:K07214,ko:K12287	ko00030,ko00053,ko00500,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00500,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751,R06200,R11307,R11308	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko02044,ko04147	-	GH5,GH9	-	Big_5,DUF285,Esterase,He_PIG,SGL
MMD1_k127_263836_0	1089551.KE386572_gene1743	1.159e-55	219.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_2659007_0	1236689.MMALV_03540	9.126e-26	108.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,3F2HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
MMD1_k127_2659007_2	882086.SacxiDRAFT_4225	1.526e-09	70.0	COG1088@1|root,COG1088@2|Bacteria	2|Bacteria	M	dTDP-glucose 4,6-dehydratase activity	-	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
MMD1_k127_2659007_1	1157490.EL26_24195	1.132e-25	110.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,4HB4S@91061|Bacilli,278ZU@186823|Alicyclobacillaceae	91061|Bacilli	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
MMD1_k127_2672736_2	574087.Acear_0714	3.181e-10	67.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,3WAE7@53433|Halanaerobiales	186801|Clostridia	S	pfam abc1	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
MMD1_k127_2672736_1	204669.Acid345_0564	8.489e-25	109.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMD1_k127_2672736_0	768710.DesyoDRAFT_3295	4.68e-57	209.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
MMD1_k127_2675986_3	420662.Mpe_A0106	7.551e-23	109.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria	1224|Proteobacteria	S	Von willebrand factor, type a	-	-	-	-	-	-	-	-	-	-	-	-	VWA
MMD1_k127_2675986_2	593750.Metfor_2078	3.496e-51	201.0	COG0704@1|root,arCOG00232@2157|Archaea,2XUZ9@28890|Euryarchaeota,2N9W2@224756|Methanomicrobia	224756|Methanomicrobia	P	Plays a role in the regulation of phosphate uptake	phoU-2	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
MMD1_k127_2675986_0	323259.Mhun_2983	7.597e-110	361.0	COG1117@1|root,arCOG00231@2157|Archaea,2XTJK@28890|Euryarchaeota,2N93D@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMD1_k127_2675986_1	309807.SRU_2295	8.816e-70	249.0	COG0581@1|root,COG0581@2|Bacteria,4NGBA@976|Bacteroidetes,1FIYE@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMD1_k127_2682012_0	351160.LRC325	9.004e-44	175.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	ABC_cobalt,Oxidored_molyb
MMD1_k127_2682012_1	1041930.Mtc_0663	1.236e-27	131.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2682012_2	439235.Dalk_2289	6.155e-08	66.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1MWIT@1224|Proteobacteria,42W2M@68525|delta/epsilon subdivisions,2WRTW@28221|Deltaproteobacteria,2MKVR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,VCBS
MMD1_k127_2736431_1	521011.Mpal_0019	8.334e-35	149.0	COG0420@1|root,arCOG00397@2157|Archaea,2XWH1@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
MMD1_k127_2736431_0	1121468.AUBR01000060_gene998	4.846e-56	203.0	COG0491@1|root,COG0491@2|Bacteria,1UZUA@1239|Firmicutes,24CIA@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD1_k127_2742270_8	1242864.D187_000023	9.58e-06	53.0	29Z39@1|root,30M0T@2|Bacteria,1Q3Q8@1224|Proteobacteria,439HD@68525|delta/epsilon subdivisions,2X4TN@28221|Deltaproteobacteria,2YZK3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2742270_5	1242864.D187_000023	3.388e-21	103.0	29Z39@1|root,30M0T@2|Bacteria,1Q3Q8@1224|Proteobacteria,439HD@68525|delta/epsilon subdivisions,2X4TN@28221|Deltaproteobacteria,2YZK3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2742270_3	498761.HM1_0326	1.31e-41	155.0	COG0662@1|root,COG0662@2|Bacteria,1V7K2@1239|Firmicutes,24JIQ@186801|Clostridia	186801|Clostridia	G	PFAM Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD1_k127_2742270_2	368408.Tpen_1107	1.767e-67	237.0	COG2102@1|root,arCOG00035@2157|Archaea,2XQDN@28889|Crenarchaeota	28889|Crenarchaeota	S	ATP binding protein	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMD1_k127_2742270_0	269799.Gmet_1189	7.461e-96	327.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,42NS9@68525|delta/epsilon subdivisions,2WJMJ@28221|Deltaproteobacteria,43SCR@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMD1_k127_2742270_7	521011.Mpal_2689	6.303e-08	63.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,2NAT0@224756|Methanomicrobia	224756|Methanomicrobia	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_2742270_1	693661.Arcve_1631	1.679e-68	249.0	COG0467@1|root,COG2229@1|root,arCOG00362@2157|Archaea,arCOG01171@2157|Archaea,2XXH5@28890|Euryarchaeota	28890|Euryarchaeota	T	small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATPase,Arf,Robl_LC7
MMD1_k127_2742270_4	1487923.DP73_04955	6.631e-34	139.0	COG0467@1|root,COG0467@2|Bacteria,1TSIM@1239|Firmicutes,24DRY@186801|Clostridia,260SN@186807|Peptococcaceae	186801|Clostridia	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
MMD1_k127_2742270_6	767817.Desgi_4134	4.239e-09	68.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	3.4.21.96	ko:K01361,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	B_lectin,DUF11,Gram_pos_anchor,Peptidase_S8,SLH,SdrD_B,fn3_5
MMD1_k127_2750540_8	511051.CSE_15390	1.251e-07	66.0	COG1502@1|root,COG2374@1|root,COG1502@2|Bacteria,COG2374@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	xynX1	-	3.1.3.8	ko:K01083,ko:K06131,ko:K06915	ko00562,ko00564,ko01100,map00562,map00564,map01100	-	R03371,R07390	RC00017,RC00078	ko00000,ko00001,ko01000	-	-	-	Exo_endo_phos,F5_F8_type_C,LTD,PLDc_2,SLH
MMD1_k127_2750540_6	96561.Dole_0842	2.539e-23	117.0	COG3209@1|root,COG3386@1|root,COG3209@2|Bacteria,COG3386@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2X5UG@28221|Deltaproteobacteria,2MN6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,NHL,RHS_repeat
MMD1_k127_2750540_3	273068.TTE0824	8.505e-47	194.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,42FS7@68295|Thermoanaerobacterales	186801|Clostridia	M	Serine protease with a broad substrate specificity	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
MMD1_k127_2750540_7	304371.MCP_0304	6.539e-16	85.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
MMD1_k127_2750540_9	743974.MBO_05752	4.681e-06	57.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,3NP0A@468|Moraxellaceae	1236|Gammaproteobacteria	J	RNA-binding protein containing KH domain, possibly ribosomal protein	yhbY	GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
MMD1_k127_2750540_4	33876.JNXY01000033_gene2309	7.582e-27	123.0	COG0382@1|root,COG0382@2|Bacteria,2IJV5@201174|Actinobacteria,4DGXV@85008|Micromonosporales	201174|Actinobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_2750540_1	673860.AciM339_0861	8.755e-130	423.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,3F2I9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
MMD1_k127_2750540_2	1236689.MMALV_07810	7.315e-51	197.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,3F2P7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2750540_0	439481.Aboo_0917	8.824e-153	497.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,3F2HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMD1_k127_2750540_5	351160.RCIX2338	1.42e-23	116.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
MMD1_k127_2758598_2	383372.Rcas_3603	5.292e-31	132.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
MMD1_k127_2758598_1	269797.Mbar_A1866	1.155e-68	244.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota,2NBJI@224756|Methanomicrobia	224756|Methanomicrobia	F	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
MMD1_k127_2758598_0	386456.JQKN01000001_gene2111	4.31e-79	273.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota	28890|Euryarchaeota	C	Fe-S protein PflX, homolog of pyruvate formate lyase activating	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMD1_k127_2762150_1	386456.JQKN01000011_gene732	2.24e-146	477.0	COG1027@1|root,arCOG01750@2157|Archaea,2Y84P@28890|Euryarchaeota	28890|Euryarchaeota	E	Fumarase C C-terminus	-	-	4.2.1.2,4.3.1.1	ko:K01679,ko:K01744	ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R00490,R01082	RC00316,RC00443,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMD1_k127_2762150_2	877455.Metbo_2112	1.501e-60	218.0	COG0479@1|root,arCOG00962@2157|Archaea,2XSXW@28890|Euryarchaeota	28890|Euryarchaeota	C	COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
MMD1_k127_2762150_0	555088.DealDRAFT_0595	6.958e-187	600.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,42KZ0@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMD1_k127_2762150_3	1380393.JHVP01000008_gene4666	1.91e-09	70.0	2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4EUCM@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2773855_1	1449063.JMLS01000002_gene1343	2.758e-41	157.0	COG2085@1|root,COG2085@2|Bacteria,1TZC5@1239|Firmicutes,4I8KA@91061|Bacilli,2703A@186822|Paenibacillaceae	91061|Bacilli	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
MMD1_k127_2773855_2	1038859.AXAU01000001_gene3619	9.902e-29	120.0	COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2UG54@28211|Alphaproteobacteria,3JY4A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
MMD1_k127_2773855_0	1457250.BBMO01000001_gene1581	1.593e-153	508.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_2777252_0	56110.Oscil6304_0577	1.25e-29	136.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria,1G2F0@1117|Cyanobacteria,1HF0C@1150|Oscillatoriales	1117|Cyanobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_2777252_1	314256.OG2516_14456	1.107e-15	90.0	COG1572@1|root,COG1864@1|root,COG2931@1|root,COG3209@1|root,COG3386@1|root,COG3391@1|root,COG3637@1|root,COG5276@1|root,COG1572@2|Bacteria,COG1864@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,COG3637@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2UHRC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FGMQ	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,He_PIG,Laminin_G_3
MMD1_k127_2784692_2	1235803.C825_04339	2.158e-16	79.0	COG0451@1|root,COG0451@2|Bacteria,4NE3U@976|Bacteroidetes,2FNS7@200643|Bacteroidia,22VZ9@171551|Porphyromonadaceae	976|Bacteroidetes	GM	NAD dependent epimerase dehydratase family	ltd	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMD1_k127_2784692_1	204669.Acid345_0627	6.057e-22	106.0	COG2267@1|root,COG2267@2|Bacteria,3Y4Q6@57723|Acidobacteria,2JJ7I@204432|Acidobacteriia	204432|Acidobacteriia	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMD1_k127_2784692_0	673860.AciM339_0553	5.476e-25	106.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD1_k127_2784692_4	1006006.Mcup_2038	1.237e-05	55.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD1_k127_2784692_3	867903.ThesuDRAFT_01997	4.429e-15	81.0	COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24U24@186801|Clostridia	186801|Clostridia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMD1_k127_2784692_5	305700.B447_03578	0.0005921	45.0	COG0484@1|root,COG0484@2|Bacteria,1REVS@1224|Proteobacteria,2VRB6@28216|Betaproteobacteria,2KWDB@206389|Rhodocyclales	206389|Rhodocyclales	O	heat shock protein DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
MMD1_k127_2786537_0	1249997.JHZW01000003_gene2150	2.305e-14	87.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,4PI47@976|Bacteroidetes,1IM97@117743|Flavobacteriia,2PI57@252356|Maribacter	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PKD
MMD1_k127_2801529_0	935557.ATYB01000008_gene5407	4.936e-11	77.0	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,2TWRD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
MMD1_k127_2801529_1	1280001.BAOA01000258_gene5235	5.952e-08	65.0	COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria,1T39R@1236|Gammaproteobacteria,1Y34S@135623|Vibrionales	135623|Vibrionales	UW	folic acid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2811315_2	374847.Kcr_0727	1.379e-07	58.0	COG3291@1|root,arCOG02508@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Malectin,PKD
MMD1_k127_2811315_0	666681.M301_0435	3.857e-30	136.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2VPQ6@28216|Betaproteobacteria	28216|Betaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
MMD1_k127_2811315_1	1249627.D779_3143	2.409e-23	118.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_281509_0	991905.SL003B_3564	1.719e-12	81.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_281509_1	1121935.AQXX01000142_gene2223	4.39e-05	46.0	COG1100@1|root,COG1100@2|Bacteria,1RIAW@1224|Proteobacteria,1S6H6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM Small GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Ras
MMD1_k127_2860607_2	335543.Sfum_0266	6.443e-30	123.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
MMD1_k127_2860607_4	1047013.AQSP01000109_gene2440	8.28e-21	102.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
MMD1_k127_2860607_1	204669.Acid345_1869	2.072e-74	267.0	COG0577@1|root,COG0577@2|Bacteria,3Y36A@57723|Acidobacteria,2JIYT@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_2860607_0	926561.KB900623_gene833	5.76e-78	270.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_2860607_3	1304872.JAGC01000009_gene1446	2.378e-24	112.0	COG4393@1|root,COG4393@2|Bacteria,1R507@1224|Proteobacteria,42NQA@68525|delta/epsilon subdivisions,2WQ0C@28221|Deltaproteobacteria,2MBVE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
MMD1_k127_2860607_5	748727.CLJU_c04240	5.834e-05	50.0	COG4908@1|root,COG4908@2|Bacteria,1TS0H@1239|Firmicutes,24B0M@186801|Clostridia,36GC8@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,DUF1298
MMD1_k127_2871626_0	1454004.AW11_04063	1.755e-19	93.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMD1_k127_2889607_6	313603.FB2170_10106	6.815e-05	57.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia,2PGXB@252356|Maribacter	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
MMD1_k127_2889607_5	1249997.JHZW01000003_gene2150	1.517e-11	79.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,4PI47@976|Bacteroidetes,1IM97@117743|Flavobacteriia,2PI57@252356|Maribacter	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PKD
MMD1_k127_2889607_0	456442.Mboo_1257	5.52e-197	640.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,2N91H@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD1_k127_2889607_2	429009.Adeg_1691	1.437e-51	189.0	COG4739@1|root,COG4739@2|Bacteria,1V3K5@1239|Firmicutes,24INA@186801|Clostridia,42FIV@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148
MMD1_k127_2889607_3	269797.Mbar_A3465	1.792e-32	130.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2N9UK@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein S8E	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMD1_k127_2889607_4	374847.Kcr_1508	4.291e-14	76.0	COG1400@1|root,arCOG01217@2157|Archaea	2157|Archaea	J	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
MMD1_k127_2889607_1	673860.AciM339_1019	4.485e-196	626.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,3F2GK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	tRNA-splicing ligase RtcB	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
MMD1_k127_2959440_1	1121430.JMLG01000004_gene898	2.933e-90	310.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
MMD1_k127_2959440_2	429009.Adeg_1333	4.494e-84	301.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
MMD1_k127_2959440_3	429009.Adeg_2015	8.071e-54	194.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
MMD1_k127_2959440_6	1121456.ATVA01000012_gene2929	5.211e-30	129.0	COG1035@1|root,COG1150@1|root,COG1035@2|Bacteria,COG1150@2|Bacteria,1R4GN@1224|Proteobacteria,42P9J@68525|delta/epsilon subdivisions,2WJ9S@28221|Deltaproteobacteria,2MGKM@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.17.1.9	ko:K00125	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_17,FrhB_FdhB_C
MMD1_k127_2959440_7	1121406.JAEX01000002_gene805	2.04e-24	104.0	COG1035@1|root,COG1152@1|root,COG1035@2|Bacteria,COG1152@2|Bacteria,1R4GN@1224|Proteobacteria,42P9J@68525|delta/epsilon subdivisions,2WJ9S@28221|Deltaproteobacteria,2MGKM@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.17.1.9	ko:K00125	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_17,FrhB_FdhB_C
MMD1_k127_2959440_8	304371.MCP_0278	2.518e-16	84.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,2NA4S@224756|Methanomicrobia	224756|Methanomicrobia	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
MMD1_k127_2959440_4	1382356.JQMP01000004_gene20	7.694e-42	157.0	COG0509@1|root,COG0509@2|Bacteria,2G6XE@200795|Chloroflexi,27YEK@189775|Thermomicrobia	189775|Thermomicrobia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMD1_k127_2959440_0	926569.ANT_14870	3.289e-241	791.0	COG0112@1|root,COG0404@1|root,COG0112@2|Bacteria,COG0404@2|Bacteria,2G624@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMD1_k127_2959440_5	1089550.ATTH01000001_gene912	1.953e-31	133.0	COG0285@1|root,COG0285@2|Bacteria,4NES8@976|Bacteroidetes,1FJ13@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMD1_k127_2961802_0	644282.Deba_2063	3.711e-27	119.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMD1_k127_2961802_1	926690.KE386573_gene1035	0.0003189	45.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,23SFQ@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
MMD1_k127_2967928_0	439235.Dalk_3657	3.372e-24	108.0	COG1917@1|root,COG1917@2|Bacteria,1RHSW@1224|Proteobacteria,42TSH@68525|delta/epsilon subdivisions,2WQ63@28221|Deltaproteobacteria,2MKHC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD1_k127_2980206_7	351160.RCIX1096	3.713e-21	98.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota,2NB35@224756|Methanomicrobia	224756|Methanomicrobia	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMD1_k127_2980206_2	673860.AciM339_0523	2.803e-86	297.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,3F38U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMD1_k127_2980206_0	192952.MM_1162	1.059e-105	352.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2NA8M@224756|Methanomicrobia	224756|Methanomicrobia	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMD1_k127_2980206_5	644282.Deba_0614	1.216e-33	141.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
MMD1_k127_2980206_9	1042877.GQS_07265	5.053e-12	78.0	COG0392@1|root,arCOG00899@2157|Archaea,2XTI1@28890|Euryarchaeota,243F4@183968|Thermococci	183968|Thermococci	S	integral membrane protein	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
MMD1_k127_2980206_11	795955.AFRW01000109_gene1439	7.851e-09	68.0	2DBIT@1|root,2Z9GU@2|Bacteria,2GN03@201174|Actinobacteria,1W8J5@1268|Micrococcaceae	201174|Actinobacteria	S	Carotene biosynthesis associated membrane protein	mptB	-	-	ko:K14337,ko:K14339	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	GT87
MMD1_k127_2980206_6	186497.PF0384	1.878e-25	118.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2433D@183968|Thermococci	183968|Thermococci	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
MMD1_k127_2980206_10	386456.JQKN01000001_gene1685	1.292e-11	71.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,23P4Y@183925|Methanobacteria	183925|Methanobacteria	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMD1_k127_2980206_12	1236689.MMALV_02950	2.047e-08	56.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y5VN@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA directed RNA polymerase, 7 kDa subunit	-	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
MMD1_k127_2980206_8	439481.Aboo_0180	6.2e-20	93.0	COG1997@1|root,arCOG04208@2157|Archaea,2Y6HQ@28890|Euryarchaeota,3F2TK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMD1_k127_2980206_3	439481.Aboo_0181	9.673e-85	287.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,3F2JS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMD1_k127_2980206_1	1054217.TALC_00327	2.937e-91	310.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,241MB@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMD1_k127_2980206_4	673860.AciM339_0867	2.047e-67	246.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,3F2JY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_1,KH_6,S1
MMD1_k127_2982439_3	1210884.HG799476_gene15385	3.193e-18	88.0	COG0241@1|root,COG0241@2|Bacteria,2IZYR@203682|Planctomycetes	203682|Planctomycetes	E	Polynucleotide kinase 3 phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_like
MMD1_k127_2982439_2	1380394.JADL01000004_gene5973	1.543e-53	209.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VF0J@28211|Alphaproteobacteria,2JYN6@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
MMD1_k127_2982439_1	592015.HMPREF1705_00545	6.606e-124	406.0	COG2605@1|root,COG2605@2|Bacteria,3TC8T@508458|Synergistetes	508458|Synergistetes	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMD1_k127_2982439_0	1094980.Mpsy_3151	1.279e-277	939.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_2982439_4	1226994.AMZB01000136_gene5045	1.752e-13	85.0	COG2373@1|root,COG2931@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,1YHF1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,VCBS
MMD1_k127_2987163_0	456320.Mvol_0794	4.181e-104	345.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_2987163_1	1041930.Mtc_2406	6.32e-24	107.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0UT@28890|Euryarchaeota,2NB7J@224756|Methanomicrobia	224756|Methanomicrobia	C	Hydrogenase maturation protease	vhtD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
MMD1_k127_2987163_2	1041930.Mtc_2406	1.112e-14	80.0	COG0680@1|root,arCOG04429@2157|Archaea,2Y0UT@28890|Euryarchaeota,2NB7J@224756|Methanomicrobia	224756|Methanomicrobia	C	Hydrogenase maturation protease	vhtD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
MMD1_k127_2987163_3	870187.Thini_1774	1.694e-14	87.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMD1_k127_2987163_4	10224.XP_006823016.1	9.419e-08	65.0	KOG0613@1|root,KOG0613@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria	33208|Metazoa	T	myosin light chain kinase activity	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	I-set,fn3
MMD1_k127_2989190_0	1041930.Mtc_2296	4.151e-285	907.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
MMD1_k127_3001757_0	452637.Oter_3066	4.352e-40	173.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DctA-YdbH
MMD1_k127_3001951_7	1317118.ATO8_06856	1.057e-21	107.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,4KK0M@93682|Roseivivax	28211|Alphaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
MMD1_k127_3001951_4	1041930.Mtc_1964	3.027e-69	246.0	COG2309@1|root,arCOG01890@2157|Archaea,2XU28@28890|Euryarchaeota	28890|Euryarchaeota	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
MMD1_k127_3001951_5	330214.NIDE4106	5.42e-60	215.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMD1_k127_3001951_3	1198449.ACAM_1295	1.024e-90	310.0	COG0162@1|root,arCOG01886@2157|Archaea,2XPU5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMD1_k127_3001951_0	1054217.TALC_00617	5.011e-165	548.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,241KS@183967|Thermoplasmata	183967|Thermoplasmata	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
MMD1_k127_3001951_1	1343739.PAP_04410	3.942e-144	469.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,243MB@183968|Thermococci	183968|Thermococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMD1_k127_3001951_10	6334.EFV46187	1.129e-08	57.0	2E8JE@1|root,2SF1C@2759|Eukaryota,3ASDN@33154|Opisthokonta,3C420@33208|Metazoa	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3001951_8	523845.AQXV01000050_gene969	1.395e-15	78.0	arCOG05874@1|root,arCOG05874@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3001951_2	56110.Oscil6304_1606	1.234e-104	369.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G2F0@1117|Cyanobacteria,1HF0C@1150|Oscillatoriales	1117|Cyanobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_3003125_3	1236689.MMALV_14200	7.769e-67	244.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,3F2JC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S3	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMD1_k127_3003125_6	573063.Metin_0632	3.958e-35	144.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,23QU0@183939|Methanococci	183939|Methanococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMD1_k127_3003125_5	673860.AciM339_1102	5.226e-50	184.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,3F2NY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMD1_k127_3003125_2	673860.AciM339_1101	1.578e-74	257.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,3F2KT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal Proteins L2, C-terminal domain	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
MMD1_k127_3003125_7	634498.mru_0853	1.34e-14	76.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,23PSB@183925|Methanobacteria	183925|Methanobacteria	J	Ribosomal protein L23	-	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMD1_k127_3003125_4	1236689.MMALV_14250	3.622e-63	231.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,3F2K6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the polypeptide exit tunnel	rpl4	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMD1_k127_3003125_1	1236689.MMALV_14260	1.149e-124	409.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,3F2H1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMD1_k127_3003125_0	671143.DAMO_2750	2.398e-158	519.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2NNNK@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase X family	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMD1_k127_3003125_8	269799.Gmet_2728	0.0005491	44.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
MMD1_k127_3007519_0	72019.SARC_11303T0	2.226e-16	94.0	KOG0379@1|root,KOG4293@1|root,KOG0379@2759|Eukaryota,KOG4293@2759|Eukaryota	2759|Eukaryota	U	DOMON domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561,Kelch_3,Kelch_4
MMD1_k127_3023872_1	1236689.MMALV_00390	3.258e-57	203.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,3F2M8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMD1_k127_3023872_0	404380.Gbem_4042	1.25e-65	253.0	COG1199@1|root,COG1199@2|Bacteria,1MVRJ@1224|Proteobacteria,42NV8@68525|delta/epsilon subdivisions,2WJIW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DEAD_2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2
MMD1_k127_3028473_3	1260251.SPISAL_07695	2.394e-15	87.0	COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,1S8ZA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
MMD1_k127_3028473_0	395493.BegalDRAFT_1429	9.92e-39	158.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,1RPW5@1236|Gammaproteobacteria,46151@72273|Thiotrichales	72273|Thiotrichales	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_3028473_2	868131.MSWAN_1244	2.815e-25	111.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,23PSW@183925|Methanobacteria	183925|Methanobacteria	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
MMD1_k127_3028473_1	304371.MCP_2185	1.605e-28	119.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota	28890|Euryarchaeota	K	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_4,HTH_5
MMD1_k127_3070110_6	1365176.N186_08500	5.988e-13	76.0	COG2253@1|root,arCOG03839@2157|Archaea	2157|Archaea	K	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	ko:K09144	-	-	-	-	ko00000	-	-	-	AbiEii
MMD1_k127_3070110_5	1197130.BAFM01000006_gene1200	5.78e-13	82.0	arCOG04522@1|root,arCOG04522@2157|Archaea,2XTU5@28890|Euryarchaeota,23U1D@183963|Halobacteria	183963|Halobacteria	O	cytochrome c biogenesis protein	dsbD	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
MMD1_k127_3070110_4	865861.AZSU01000006_gene1250	4.378e-13	83.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia	186801|Clostridia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
MMD1_k127_3070110_3	511051.CSE_09940	8.327e-18	92.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
MMD1_k127_3070110_2	1169154.KB897782_gene4893	3.103e-24	119.0	COG1515@1|root,COG1515@2|Bacteria,2GJEZ@201174|Actinobacteria	201174|Actinobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
MMD1_k127_3070110_7	330779.Saci_0975	1.888e-05	50.0	COG1599@1|root,arCOG01510@2157|Archaea,2XQQM@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
MMD1_k127_3070110_1	673860.AciM339_1144	1.37e-98	334.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,3F389@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMD1_k127_3070110_0	226186.BT_0787	1.201e-106	357.0	COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,2FM2M@200643|Bacteroidia,4AN34@815|Bacteroidaceae	976|Bacteroidetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
MMD1_k127_3085779_2	192952.MM_3150	1.733e-51	194.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
MMD1_k127_3085779_0	673860.AciM339_1448	1.643e-117	401.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
MMD1_k127_3085779_3	439481.Aboo_1120	2.534e-40	166.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,3F2R2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
MMD1_k127_3085779_5	456442.Mboo_0348	3.285e-26	112.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y02Z@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD1_k127_3085779_4	498848.TaqDRAFT_5037	7.894e-28	114.0	COG2361@1|root,COG2361@2|Bacteria,1WKJ0@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86,NTP_transf_2
MMD1_k127_3085779_6	1463820.JOGW01000015_gene2457	2.67e-13	83.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Abhydrolase_6
MMD1_k127_3085779_1	1457250.BBMO01000001_gene1581	1.639e-112	381.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_3098938_7	755732.Fluta_0614	7.715e-07	62.0	2DQEZ@1|root,336F0@2|Bacteria,4NUK8@976|Bacteroidetes,1I4H2@117743|Flavobacteriia,2PBW4@246874|Cryomorphaceae	976|Bacteroidetes	S	Reeler domain	-	-	-	-	-	-	-	-	-	-	-	-	Reeler
MMD1_k127_3098938_5	436308.Nmar_1073	1.401e-15	90.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
MMD1_k127_3098938_8	525903.Taci_0617	2.683e-05	55.0	2ENZG@1|root,33GKC@2|Bacteria,3TBSZ@508458|Synergistetes	508458|Synergistetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3098938_0	192952.MM_3272	3.903e-144	472.0	COG0477@1|root,arCOG00143@2157|Archaea,2XUTR@28890|Euryarchaeota,2N94Q@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMD1_k127_3098938_3	446468.Ndas_2431	1.801e-30	123.0	COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria,4EJQ1@85012|Streptosporangiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,SnoaL_2
MMD1_k127_3098938_4	1382356.JQMP01000003_gene2027	1.994e-27	120.0	COG0412@1|root,COG0412@2|Bacteria,2G9WC@200795|Chloroflexi,27Z94@189775|Thermomicrobia	189775|Thermomicrobia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMD1_k127_3098938_6	457429.ABJI02000843_gene3316	6.863e-15	84.0	28ME7@1|root,2ZARX@2|Bacteria,2GTJG@201174|Actinobacteria	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
MMD1_k127_3098938_1	1094980.Mpsy_2655	3.398e-124	413.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
MMD1_k127_3098938_2	926550.CLDAP_28350	2.188e-76	269.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
MMD1_k127_3107544_0	1173020.Cha6605_4440	4.067e-114	414.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria	1117|Cyanobacteria	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
MMD1_k127_3132913_0	1192034.CAP_1012	5.567e-51	211.0	COG4719@1|root,COG4870@1|root,COG4719@2|Bacteria,COG4870@2|Bacteria,1R0BA@1224|Proteobacteria,42VBW@68525|delta/epsilon subdivisions,2X811@28221|Deltaproteobacteria,2Z3J2@29|Myxococcales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_3132913_2	240016.ABIZ01000001_gene117	5.957e-11	78.0	COG2911@1|root,COG2931@1|root,COG3203@1|root,COG3209@1|root,COG3266@1|root,COG4782@1|root,COG4932@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3203@2|Bacteria,COG3209@2|Bacteria,COG3266@2|Bacteria,COG4782@2|Bacteria,COG4932@2|Bacteria,46S8F@74201|Verrucomicrobia,2IV48@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat
MMD1_k127_3132913_3	589924.Ferp_1921	2.203e-10	72.0	arCOG06532@1|root,arCOG06532@2157|Archaea,2Y12Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
MMD1_k127_3132913_1	1313421.JHBV01000052_gene192	3.548e-13	83.0	COG3209@1|root,COG3210@1|root,COG4447@1|root,COG4932@1|root,COG5384@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5384@2|Bacteria,4PPW2@976|Bacteroidetes,1J12N@117747|Sphingobacteriia	2|Bacteria	JMU	domain protein	-	-	3.2.1.4	ko:K01179,ko:K19360,ko:K21449	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko02000,ko03036	1.B.40.2	GH5,GH9	-	FIVAR,LRR_5,Phospholip_A2_3
MMD1_k127_3158437_1	436308.Nmar_1073	2.707e-48	200.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
MMD1_k127_3158437_0	251221.35214774	3.677e-75	281.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
MMD1_k127_316062_2	316274.Haur_4661	1.428e-09	59.0	COG0477@1|root,COG2814@2|Bacteria,2G5ZW@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD1_k127_316062_0	1267535.KB906767_gene1375	6.606e-73	255.0	COG0702@1|root,COG0702@2|Bacteria,3Y5MR@57723|Acidobacteria,2JNGU@204432|Acidobacteriia	204432|Acidobacteriia	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
MMD1_k127_316062_1	479434.Sthe_1814	2.213e-43	169.0	COG1999@1|root,COG3391@1|root,COG1999@2|Bacteria,COG3391@2|Bacteria,2GAQJ@200795|Chloroflexi,27XX5@189775|Thermomicrobia	189775|Thermomicrobia	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	NHL
MMD1_k127_3195032_1	634956.Geoth_0412	2.983e-109	358.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,4HAW9@91061|Bacilli,1WF5U@129337|Geobacillus	91061|Bacilli	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
MMD1_k127_3195032_0	224719.Abm4_0861	5.228e-211	670.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,23NKS@183925|Methanobacteria	183925|Methanobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
MMD1_k127_3195032_2	1031288.AXAA01000005_gene2013	1.689e-61	216.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
MMD1_k127_320904_0	1230460.C495_02305	1.31e-108	366.0	COG3243@1|root,arCOG06344@2157|Archaea,2XSZS@28890|Euryarchaeota,23SX8@183963|Halobacteria	183963|Halobacteria	I	poly(R)-hydroxyalkanoic acid synthase subunit PhaC	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,HHH_5
MMD1_k127_320904_2	694430.Natoc_1372	3.479e-05	55.0	arCOG06343@1|root,arCOG06343@2157|Archaea,2XTS0@28890|Euryarchaeota,23S72@183963|Halobacteria	183963|Halobacteria	S	poly-hydroxybutyrate biosynthetic process	phaE	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
MMD1_k127_320904_1	272558.10175111	1.551e-80	275.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1ZCDY@1386|Bacillus	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
MMD1_k127_326680_1	368407.Memar_0912	7.619e-57	223.0	COG0642@1|root,arCOG03567@1|root,arCOG03567@2157|Archaea,arCOG06192@2157|Archaea,2Y7VV@28890|Euryarchaeota,2NBN0@224756|Methanomicrobia	2157|Archaea	T	PFAM ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9
MMD1_k127_326680_4	1519464.HY22_08105	1.238e-16	94.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1FEZK@1090|Chlorobi	2|Bacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg
MMD1_k127_326680_0	247490.KSU1_C1572	7.357e-263	841.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,2IWSR@203682|Planctomycetes	203682|Planctomycetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,Response_reg
MMD1_k127_326680_3	768671.ThimaDRAFT_0516	2.224e-20	107.0	COG5001@1|root,COG5001@2|Bacteria,1MXAN@1224|Proteobacteria,1RRT0@1236|Gammaproteobacteria,1WXQQ@135613|Chromatiales	135613|Chromatiales	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3
MMD1_k127_326680_2	867903.ThesuDRAFT_02285	1.953e-45	187.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24IAZ@186801|Clostridia,3WD9X@538999|Clostridiales incertae sedis	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9
MMD1_k127_3271371_0	292459.STH718	0.000791	53.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,PPC,Peptidase_S8
MMD1_k127_3279680_2	1347368.HG964403_gene4490	5.48e-47	193.0	COG4632@1|root,COG5492@1|root,COG4632@2|Bacteria,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQJJ@91061|Bacilli	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMD1_k127_3279680_0	717606.PaecuDRAFT_2033	2.025e-113	413.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_3279680_3	1028801.RG1141_CH33670	0.0002538	55.0	COG0689@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG0689@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria,4B9W3@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,He_PIG,HemolysinCabind,P_proprotein,VWA_2
MMD1_k127_3279680_1	1123252.ATZF01000027_gene1612	1.88e-91	324.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_3279862_2	351160.RCIX702	3.027e-46	174.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
MMD1_k127_3279862_7	519442.Huta_0525	1.722e-09	66.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,23VKT@183963|Halobacteria	183963|Halobacteria	J	exosome subunit	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
MMD1_k127_3279862_4	439481.Aboo_1308	2.015e-24	111.0	COG2524@1|root,arCOG00610@2157|Archaea,2Y88Y@28890|Euryarchaeota,3F2VE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD1_k127_3279862_3	694440.JOMF01000004_gene1393	1.179e-44	190.0	COG0457@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	ko:K07452	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	TPR_1,TPR_12,TPR_16,TPR_2,TPR_8
MMD1_k127_3279862_6	388467.A19Y_4609	7.053e-17	98.0	COG0457@1|root,COG0457@2|Bacteria,1G07G@1117|Cyanobacteria,1H8X6@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
MMD1_k127_3279862_0	118173.KB235914_gene1270	9.747e-146	523.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
MMD1_k127_3279862_5	368408.Tpen_1488	1.577e-23	111.0	COG0340@1|root,arCOG01940@2157|Archaea,2XQ93@28889|Crenarchaeota	28889|Crenarchaeota	H	biotin lipoate A B protein ligase	-	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
MMD1_k127_3279862_1	1254432.SCE1572_37155	3.525e-60	220.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42MY3@68525|delta/epsilon subdivisions,2WJEF@28221|Deltaproteobacteria,2Z31P@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
MMD1_k127_3280079_0	1457250.BBMO01000001_gene1581	2.017e-06	61.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_3315241_9	1101188.KI912156_gene4370	0.0007844	42.0	COG0725@1|root,COG0725@2|Bacteria,2IIQN@201174|Actinobacteria	201174|Actinobacteria	P	Bacterial extracellular solute-binding protein	-	-	4.1.1.104,5.3.3.7	ko:K02020,ko:K22003,ko:K22130	ko00660,ko02010,map00660,map02010	M00189	R02244	RC00668	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	Aldolase_II,SBP_bac_11
MMD1_k127_3315241_1	572546.Arcpr_1039	9.159e-157	520.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMD1_k127_3315241_7	216591.BCAM2566	6.289e-28	120.0	COG3153@1|root,COG3153@2|Bacteria,1MYY0@1224|Proteobacteria,2VYXG@28216|Betaproteobacteria,1KBY8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_3315241_0	1236689.MMALV_12140	5.193e-265	844.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,3F2MC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PEP-utilising enzyme, mobile domain	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMD1_k127_3315241_3	243231.GSU0751	6.925e-57	203.0	COG5423@1|root,COG5423@2|Bacteria,1N9C0@1224|Proteobacteria,42W42@68525|delta/epsilon subdivisions,2WR81@28221|Deltaproteobacteria,43TPZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
MMD1_k127_3315241_4	1125863.JAFN01000001_gene3012	1.58e-55	203.0	COG1131@1|root,COG1131@2|Bacteria,1RGM1@1224|Proteobacteria,43ADE@68525|delta/epsilon subdivisions,2X5TA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
MMD1_k127_3315241_6	192952.MM_2397	1.507e-31	139.0	COG2386@1|root,arCOG01328@2157|Archaea,2XTAS@28890|Euryarchaeota,2NAJD@224756|Methanomicrobia	224756|Methanomicrobia	O	CcmB protein	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
MMD1_k127_3315241_5	768706.Desor_0549	2.644e-50	188.0	COG0755@1|root,COG0755@2|Bacteria,1V4A6@1239|Firmicutes,24IWH@186801|Clostridia,263XX@186807|Peptococcaceae	186801|Clostridia	O	ABC-type transport system involved in cytochrome c biogenesis, permease component	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
MMD1_k127_3315241_8	1384484.AEQU_0556	1.312e-05	54.0	COG2332@1|root,COG2332@2|Bacteria,2HUFT@201174|Actinobacteria,4CUH1@84998|Coriobacteriia	84998|Coriobacteriia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
MMD1_k127_3315241_2	439481.Aboo_1435	5.196e-148	482.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,3F33N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMD1_k127_3325924_3	351160.RCIX1084	2.838e-39	168.0	COG0840@1|root,arCOG02348@1|root,arCOG02320@2157|Archaea,arCOG02348@2157|Archaea	2157|Archaea	T	PAS domain	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
MMD1_k127_3325924_0	70601.3257941	5.573e-79	274.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2430R@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
MMD1_k127_3325924_1	439481.Aboo_0831	9.555e-52	200.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,3F2KR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
MMD1_k127_3325924_6	1278307.KB906970_gene1073	5.651e-05	55.0	2FHFB@1|root,3499D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3325924_4	1236689.MMALV_02580	9.683e-37	153.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,3F2QX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Pfam:Methyltransf_26	trmG10	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
MMD1_k127_3325924_2	797209.ZOD2009_18544	4.744e-43	169.0	COG0500@1|root,arCOG04989@2157|Archaea,2XWEU@28890|Euryarchaeota,23V0C@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMD1_k127_3325924_5	69014.TK0929	5.473e-16	85.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
MMD1_k127_3329697_0	1041930.Mtc_2073	8.261e-52	200.0	COG0206@1|root,COG1234@1|root,COG1650@1|root,arCOG00501@2157|Archaea,arCOG01616@2157|Archaea,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
MMD1_k127_3329697_2	198628.Dda3937_01477	7.79e-16	93.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,DUF4347,DUF5122,He_PIG,OmpA_membrane
MMD1_k127_3329697_3	1121930.AQXG01000004_gene2867	4.988e-05	57.0	COG1404@1|root,COG4254@1|root,COG1404@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FecR
MMD1_k127_3329697_1	765420.OSCT_0887	2.36e-51	207.0	COG1716@1|root,COG1716@2|Bacteria,2G9KV@200795|Chloroflexi,376M0@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Peptidase_C11
MMD1_k127_3330493_0	479434.Sthe_0904	4.789e-17	92.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi,27XVU@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_3330493_1	386456.JQKN01000002_gene2415	1.042e-09	68.0	COG1714@1|root,arCOG03633@2157|Archaea,2Y140@28890|Euryarchaeota,23P6J@183925|Methanobacteria	183925|Methanobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
MMD1_k127_3337693_1	1054217.TALC_01206	5.922e-96	329.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,241P5@183967|Thermoplasmata	183967|Thermoplasmata	J	histidyl-tRNA aminoacylation	hisS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMD1_k127_3337693_3	1041930.Mtc_1286	1.761e-57	207.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,2N9HT@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
MMD1_k127_3337693_0	483219.LILAB_12530	7.701e-112	390.0	COG0475@1|root,COG0490@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,1QTSD@1224|Proteobacteria,42QG4@68525|delta/epsilon subdivisions,2WKK8@28221|Deltaproteobacteria,2YTX2@29|Myxococcales	28221|Deltaproteobacteria	P	TrkA-C domain	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C
MMD1_k127_3337693_2	1382356.JQMP01000003_gene1745	3.641e-72	256.0	COG0183@1|root,COG0183@2|Bacteria,2G63J@200795|Chloroflexi,27YZ2@189775|Thermomicrobia	189775|Thermomicrobia	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMD1_k127_3347083_0	192952.MM_2581	1.352e-112	379.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,2N915@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMD1_k127_3347083_2	224325.AF_1693	1.101e-97	329.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,245YB@183980|Archaeoglobi	183980|Archaeoglobi	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMD1_k127_3347083_3	797209.ZOD2009_09880	2.071e-12	78.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,23SVZ@183963|Halobacteria	183963|Halobacteria	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	ubiA2	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMD1_k127_3347083_1	673860.AciM339_0552	8.984e-103	347.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMD1_k127_3347083_4	439481.Aboo_1528	9.315e-10	62.0	arCOG03397@1|root,arCOG03397@2157|Archaea,2Y76W@28890|Euryarchaeota,3F3HH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3347345_0	1236689.MMALV_01480	1.799e-61	220.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,3F2NZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_20,HTH_24,HTH_Crp_2
MMD1_k127_3347345_1	589924.Ferp_0281	6.713e-14	79.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,245TU@183980|Archaeoglobi	183980|Archaeoglobi	S	GTP-binding protein	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
MMD1_k127_3350162_2	929712.KI912613_gene722	1.275e-51	197.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4CP6P@84995|Rubrobacteria	84995|Rubrobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD1_k127_3350162_0	272844.PAB2227	2.212e-118	394.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,243KU@183968|Thermococci	183968|Thermococci	K	Alanine-glyoxylate amino-transferase	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMD1_k127_3350162_1	1236689.MMALV_10400	3.631e-75	267.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,3F2IJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22
MMD1_k127_3350162_3	1236689.MMALV_13600	8.648e-31	131.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,3F2JE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.2,3.5.2.3,3.5.2.5	ko:K01464,ko:K01465,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00051,M00546	R01993,R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
MMD1_k127_3355165_1	1196323.ALKF01000178_gene230	5.348e-69	268.0	COG1404@1|root,COG4733@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,1TQRU@1239|Firmicutes,4HV3C@91061|Bacilli,26VJF@186822|Paenibacillaceae	91061|Bacilli	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,fn3
MMD1_k127_3355165_3	631362.Thi970DRAFT_04156	1.181e-13	77.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,1RR2P@1236|Gammaproteobacteria,1WVXQ@135613|Chromatiales	135613|Chromatiales	O	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_11,TPR_16,TPR_2,TPR_8
MMD1_k127_3355165_2	1236689.MMALV_10380	4.734e-41	167.0	COG2516@1|root,arCOG00662@2157|Archaea,2XV52@28890|Euryarchaeota	28890|Euryarchaeota	S	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMD1_k127_3355165_0	439481.Aboo_0519	3.079e-93	314.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMD1_k127_3367462_0	1054217.TALC_00198	2.723e-15	84.0	arCOG05338@1|root,arCOG05338@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3370020_2	631362.Thi970DRAFT_01386	4.025e-11	69.0	COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria,1WY53@135613|Chromatiales	135613|Chromatiales	P	Belongs to the DsrF TusC family	dsrF	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
MMD1_k127_3370020_1	771875.Ferpe_0829	2.65e-16	83.0	COG1553@1|root,COG1553@2|Bacteria,2GD3U@200918|Thermotogae	200918|Thermotogae	P	PFAM DsrE	-	-	-	ko:K07235	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE
MMD1_k127_3370020_0	419665.Maeo_0966	1.64e-23	107.0	COG2210@1|root,arCOG02064@2157|Archaea,2XT1G@28890|Euryarchaeota	28890|Euryarchaeota	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
MMD1_k127_3374705_3	1227487.C474_03160	0.0003059	46.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,23T3G@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
MMD1_k127_3374705_1	368407.Memar_1425	8.484e-69	247.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2N9P3@224756|Methanomicrobia	224756|Methanomicrobia	K	Phosphate uptake regulator, PhoU	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMD1_k127_3374705_2	1236902.ANAS01000038_gene3086	1.216e-29	124.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4EJEW@85012|Streptosporangiales	201174|Actinobacteria	T	Low molecular weight phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
MMD1_k127_3374705_0	944480.ATUV01000001_gene602	1.69e-170	556.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria	1224|Proteobacteria	Q	4-hydroxyphenylacetate	-	-	-	-	-	-	-	-	-	-	-	-	HpaB,HpaB_N
MMD1_k127_3385762_0	690850.Desaf_0585	1.469e-117	402.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIWK@28221|Deltaproteobacteria,2M8CW@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05559,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	Proton_antipo_M,Proton_antipo_N
MMD1_k127_3385762_2	882.DVU_0433	1.715e-54	201.0	COG0650@1|root,COG0650@2|Bacteria,1QUK1@1224|Proteobacteria,42PHN@68525|delta/epsilon subdivisions,2WKPJ@28221|Deltaproteobacteria,2M94K@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM respiratory-chain NADH dehydrogenase subunit 1	-	-	-	ko:K14087	-	-	-	-	ko00000	-	-	-	NADHdh
MMD1_k127_3385762_3	1089553.Tph_c21340	1.314e-52	214.0	COG3260@1|root,COG3260@2|Bacteria,1UHYA@1239|Firmicutes,24I1D@186801|Clostridia,42GCG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.6.5.3	ko:K00331,ko:K14088	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
MMD1_k127_3385762_7	1125863.JAFN01000001_gene1398	8.979e-05	50.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42VHN@68525|delta/epsilon subdivisions,2WSDA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
MMD1_k127_3385762_1	351627.Csac_1538	1.389e-106	358.0	COG3261@1|root,COG3261@2|Bacteria,1VZGX@1239|Firmicutes,248UJ@186801|Clostridia,42FMX@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase chain 49kDa	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
MMD1_k127_3385762_5	1408324.JNJK01000007_gene2993	3.391e-23	103.0	COG1143@1|root,COG1143@2|Bacteria,1VDBV@1239|Firmicutes,24SHQ@186801|Clostridia,27TV4@186928|unclassified Lachnospiraceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338,ko:K14091	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4,Fer4_7
MMD1_k127_3385762_4	416591.Tlet_1498	4.198e-52	187.0	COG2033@1|root,COG2033@2|Bacteria,2GD7N@200918|Thermotogae	200918|Thermotogae	C	Desulfoferrodoxin ferrous iron-binding	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
MMD1_k127_3385762_6	552811.Dehly_1422	8.752e-11	65.0	COG0500@1|root,COG2226@2|Bacteria,2G6GD@200795|Chloroflexi,34CS0@301297|Dehalococcoidia	301297|Dehalococcoidia	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
MMD1_k127_3407256_1	647113.Metok_0755	3.742e-15	86.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWKF@28890|Euryarchaeota,23QU2@183939|Methanococci	183939|Methanococci	K	Transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
MMD1_k127_3407256_0	671143.DAMO_1208	2.595e-208	658.0	COG0365@1|root,COG0365@2|Bacteria,2NNSQ@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acs	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMD1_k127_3408214_1	234267.Acid_5783	8.148e-101	350.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMD1_k127_3408214_4	1122915.AUGY01000053_gene1899	8.077e-07	60.0	COG1378@1|root,COG1378@2|Bacteria,1TSY3@1239|Firmicutes,4HE0V@91061|Bacilli,26T34@186822|Paenibacillaceae	91061|Bacilli	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMD1_k127_3408214_2	304371.MCP_2069	9.48e-38	157.0	COG1404@1|root,COG1470@1|root,arCOG00702@2157|Archaea,arCOG02081@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
MMD1_k127_3408214_3	1380390.JIAT01000009_gene1733	4.318e-14	84.0	COG2201@1|root,COG2201@2|Bacteria,2HQVC@201174|Actinobacteria,4CSNA@84995|Rubrobacteria	84995|Rubrobacteria	NT	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
MMD1_k127_3408214_0	1380393.JHVP01000003_gene1042	4.428e-115	382.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4ERH0@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
MMD1_k127_3409053_2	1453503.AU05_15180	4.691e-06	55.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RMM7@1236|Gammaproteobacteria,1YEF3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
MMD1_k127_3409053_1	439481.Aboo_0715	1.652e-32	133.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2Y71S@28890|Euryarchaeota,3F36K@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3409053_0	439481.Aboo_0716	2.932e-71	250.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTU3@28890|Euryarchaeota,3F31P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Rad51	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_34108_0	1410653.JHVC01000005_gene2467	1.614e-106	363.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36DXA@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMD1_k127_34108_1	663278.Ethha_2233	0.0001297	55.0	COG1409@1|root,COG1409@2|Bacteria,1V5H1@1239|Firmicutes,25BK1@186801|Clostridia	186801|Clostridia	MU	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	FIVAR,Laminin_G_3,Metallophos
MMD1_k127_3423941_0	697303.Thewi_0616	3.593e-150	484.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108,1.3.8.1	ko:K00248,ko:K22430	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD1_k127_3423941_2	1449126.JQKL01000002_gene1588	8.061e-97	323.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia	186801|Clostridia	C	electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMD1_k127_3423941_1	1449126.JQKL01000090_gene491	1.164e-131	443.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia	186801|Clostridia	C	electron transfer flavoprotein	etfA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
MMD1_k127_3423941_3	1150474.JQJI01000017_gene593	5.552e-27	115.0	COG1661@1|root,COG1661@2|Bacteria,2GDE0@200918|Thermotogae	200918|Thermotogae	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMD1_k127_3431252_1	593750.Metfor_2721	3.003e-119	398.0	COG0798@1|root,arCOG02190@2157|Archaea,2XTQC@28890|Euryarchaeota,2N935@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
MMD1_k127_3431252_7	1173029.JH980292_gene1643	5.12e-13	79.0	COG0730@1|root,COG0730@2|Bacteria,1G0FY@1117|Cyanobacteria,1H7AB@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMD1_k127_3431252_6	747365.Thena_0382	2.898e-20	101.0	COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,24AEX@186801|Clostridia	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMD1_k127_3431252_0	292459.STH3194	4.297e-130	433.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia	186801|Clostridia	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMD1_k127_3431252_4	1121468.AUBR01000027_gene2875	4.836e-49	182.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,42GD8@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
MMD1_k127_3431252_5	273075.Ta1149	3.256e-30	126.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMD1_k127_3431252_2	266117.Rxyl_1330	4.158e-93	334.0	COG0343@1|root,COG0343@2|Bacteria,2GMWY@201174|Actinobacteria,4CPB3@84995|Rubrobacteria	84995|Rubrobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
MMD1_k127_3431252_3	867903.ThesuDRAFT_01678	9.206e-93	323.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WCFH@538999|Clostridiales incertae sedis	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMD1_k127_343994_0	1303518.CCALI_02684	3.201e-117	424.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,CarboxypepD_reg,Plug,Thiol-ester_cl
MMD1_k127_3440483_1	1379698.RBG1_1C00001G0361	3.808e-81	289.0	COG0530@1|root,COG0530@2|Bacteria,2NPSH@2323|unclassified Bacteria	2|Bacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMD1_k127_3440483_0	1236689.MMALV_16840	1.283e-151	493.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,3F2IP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Aldolase/RraA	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
MMD1_k127_3440483_2	693661.Arcve_1588	1.017e-05	57.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,24693@183980|Archaeoglobi	183980|Archaeoglobi	N	Peptidase A24B, FlaK domain protein	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
MMD1_k127_3441676_0	1136417.AZWE01000013_gene2350	0.0006465	54.0	COG3188@1|root,COG3188@2|Bacteria,2HQZC@201174|Actinobacteria,4DMG6@85008|Micromonosporales	201174|Actinobacteria	NU	Glycosyl hydrolase family 48	cbhB	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_48
MMD1_k127_3452148_1	621372.ACIH01000198_gene2637	2.233e-13	85.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli,26QNY@186822|Paenibacillaceae	91061|Bacilli	O	CarboxypepD_reg-like domain	bprF	-	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,PKD,Peptidase_M6,Peptidase_S8
MMD1_k127_3452148_0	715451.ambt_13580	2.01e-16	91.0	COG2373@1|root,COG2911@1|root,COG3210@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,465B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
MMD1_k127_3465096_0	550540.Fbal_0429	7.729e-23	114.0	COG3240@1|root,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	estA	GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0016289,GO:0016290,GO:0016787,GO:0016788,GO:0016790,GO:0047617,GO:0052689	3.1.3.8	ko:K01083,ko:K11018,ko:K12686,ko:K15349,ko:K21831	ko00562,ko05132,map00562,map05132	-	R03371	RC00078	ko00000,ko00001,ko01000,ko02000,ko02042,ko02044	1.B.12.8	-	-	Autotransporter,Lipase_GDSL
MMD1_k127_3466055_1	1304877.KI519400_gene1078	1.554e-07	66.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K64C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HCBP_related,He_PIG,HemolysinCabind
MMD1_k127_3466055_0	1041930.Mtc_0621	3.891e-71	251.0	arCOG02754@1|root,arCOG10890@1|root,arCOG02754@2157|Archaea,arCOG10890@2157|Archaea,2Y0JM@28890|Euryarchaeota	28890|Euryarchaeota	L	SPTR Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
MMD1_k127_3471000_1	926550.CLDAP_28350	2.339e-33	146.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
MMD1_k127_3471000_0	1054217.TALC_00056	2.902e-129	429.0	COG1031@1|root,arCOG01359@2157|Archaea,2XSVQ@28890|Euryarchaeota	28890|Euryarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	HHH,HHH_3,Radical_SAM
MMD1_k127_3472774_5	1382306.JNIM01000001_gene3499	1.245e-30	126.0	COG1051@1|root,COG1051@2|Bacteria,2GA98@200795|Chloroflexi	200795|Chloroflexi	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMD1_k127_3472774_2	342949.PNA2_0655	7.935e-43	166.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,243A1@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMD1_k127_3472774_4	644282.Deba_2984	5.115e-38	149.0	COG0509@1|root,COG0509@2|Bacteria,1PSYE@1224|Proteobacteria,430Z8@68525|delta/epsilon subdivisions,2WVT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glycine cleavage system H protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMD1_k127_3472774_3	706587.Desti_0171	7.915e-39	154.0	COG1150@1|root,COG1150@2|Bacteria,1R44N@1224|Proteobacteria,42NTE@68525|delta/epsilon subdivisions,2WJN8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Nitrate reductase gamma subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMD1_k127_3472774_1	706587.Desti_0172	2.881e-74	259.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Heterodisulfide reductase subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_3472774_0	573064.Mefer_0237	5.913e-112	375.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD1_k127_3473538_0	1120936.KB907221_gene2226	2.269e-05	57.0	COG1073@1|root,COG1073@2|Bacteria,2GNUS@201174|Actinobacteria,4EI2H@85012|Streptosporangiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
MMD1_k127_3477010_1	269797.Mbar_A2074	9.459e-29	126.0	COG4002@1|root,arCOG00854@2157|Archaea,2XVHH@28890|Euryarchaeota,2NBJX@224756|Methanomicrobia	224756|Methanomicrobia	S	methyltransferase activity	mtxX	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
MMD1_k127_3477010_0	70601.3256392	5.217e-42	177.0	COG2413@1|root,arCOG04066@2157|Archaea,2XSZH@28890|Euryarchaeota,24347@183968|Thermococci	183968|Thermococci	S	Nucleotidyltransferase domain	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD1_k127_3477010_2	673860.AciM339_1080	8.437e-18	90.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y18J@28890|Euryarchaeota,3F2UV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	TOPRIM	-	-	-	-	-	-	-	-	-	-	-	-	Toprim
MMD1_k127_3477010_6	1236689.MMALV_01350	1.118e-10	71.0	COG1872@1|root,arCOG04058@2157|Archaea	2157|Archaea	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMD1_k127_3477010_5	237368.SCABRO_03564	2.356e-12	82.0	COG3291@1|root,COG3291@2|Bacteria,2J1GZ@203682|Planctomycetes	203682|Planctomycetes	U	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_3477010_9	1122917.KB899666_gene3345	0.0009301	53.0	COG5184@1|root,COG5297@1|root,COG5184@2|Bacteria,COG5297@2|Bacteria,1TXPR@1239|Firmicutes,4I6QI@91061|Bacilli,26UAT@186822|Paenibacillaceae	2|Bacteria	G	Cellulase N-terminal ig-like domain	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CHU_C,Cadherin-like,CelD_N,Cu_amine_oxidN1,DUF11,Glyco_hydro_66,Glyco_hydro_9,RCC1_2,RicinB_lectin_2,Ricin_B_lectin,SLH,fn3
MMD1_k127_3477010_8	224719.Abm4_0531	0.0006473	47.0	COG1873@1|root,arCOG02155@2157|Archaea	2157|Archaea	S	PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMD1_k127_3477010_3	279714.FuraDRAFT_2764	4.277e-17	86.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria,2KPKJ@206351|Neisseriales	206351|Neisseriales	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
MMD1_k127_3482132_4	379066.GAU_0515	3.185e-14	85.0	COG4447@1|root,COG5492@1|root,COG4447@2|Bacteria,COG5492@2|Bacteria,1ZUDA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
MMD1_k127_3482132_0	304371.MCP_2982	1.371e-138	451.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,2N980@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
MMD1_k127_3482132_1	1304284.L21TH_1612	5.279e-118	409.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	tnaT	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
MMD1_k127_3482132_2	224325.AF_0575	4.256e-31	132.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2467X@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD1_k127_3482132_3	469383.Cwoe_4613	2.155e-25	111.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4CPFB@84995|Rubrobacteria	84995|Rubrobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD1_k127_353881_5	439481.Aboo_0134	4.472e-42	180.0	COG4870@1|root,arCOG02499@1|root,arCOG05978@1|root,arCOG02499@2157|Archaea,arCOG03607@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_5,Kelch_1,NosD,Peptidase_C1,S_layer_C,fn3
MMD1_k127_353881_3	717606.PaecuDRAFT_2033	1.397e-85	323.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_353881_1	1054217.TALC_01492	2.142e-105	354.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota,241W7@183967|Thermoplasmata	183967|Thermoplasmata	O	AIR synthase related protein, C-terminal domain	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
MMD1_k127_353881_11	1123229.AUBC01000011_gene2329	0.0005507	48.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,3JV9H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
MMD1_k127_353881_8	1227453.C444_00572	7.994e-18	97.0	arCOG06011@1|root,arCOG06011@2157|Archaea,2XWQ2@28890|Euryarchaeota,23V6N@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
MMD1_k127_353881_10	797303.Natpe_0123	2.226e-10	73.0	arCOG06011@1|root,arCOG06011@2157|Archaea,2XXCS@28890|Euryarchaeota,23VSF@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
MMD1_k127_353881_2	1382306.JNIM01000001_gene194	9.139e-99	341.0	COG0409@1|root,COG0409@2|Bacteria,2G5MS@200795|Chloroflexi	200795|Chloroflexi	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
MMD1_k127_353881_9	647113.Metok_1476	1.27e-16	85.0	COG0375@1|root,arCOG04426@2157|Archaea,2XY46@28890|Euryarchaeota,23QZX@183939|Methanococci	183939|Methanococci	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
MMD1_k127_353881_7	935948.KE386495_gene1383	5.062e-19	92.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,24UXU@186801|Clostridia,42HA3@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
MMD1_k127_353881_0	1236689.MMALV_04840	2.55e-193	627.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,3F2IG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	TIGRFAM NiFe hydrogenase maturation protein HypF	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
MMD1_k127_353881_4	694440.JOMF01000007_gene883	5.752e-72	250.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUJS@28890|Euryarchaeota,2N9SQ@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
MMD1_k127_353881_6	1158318.ATXC01000001_gene574	2.004e-32	132.0	COG0864@1|root,COG0864@2|Bacteria,2G47H@200783|Aquificae	200783|Aquificae	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
MMD1_k127_3544303_1	439481.Aboo_0588	2.034e-25	117.0	COG1340@1|root,arCOG01159@2157|Archaea,2Y70M@28890|Euryarchaeota,3F338@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3544303_0	452652.KSE_00980t	1.031e-67	252.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,2M2GY@2063|Kitasatospora	201174|Actinobacteria	GJM	Nucleotidyl transferase	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
MMD1_k127_3544303_2	673860.AciM339_1278	3.354e-09	63.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,3F2RP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_5
MMD1_k127_3579888_0	1125863.JAFN01000001_gene752	6.093e-26	110.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD1_k127_3579888_2	1382306.JNIM01000001_gene208	5.509e-07	60.0	COG0671@1|root,COG0671@2|Bacteria,2G93T@200795|Chloroflexi	200795|Chloroflexi	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
MMD1_k127_3612348_5	163908.KB235896_gene839	0.0002475	49.0	COG0631@1|root,COG0631@2|Bacteria,1FZZK@1117|Cyanobacteria,1HJGG@1161|Nostocales	1117|Cyanobacteria	T	PFAM protein phosphatase 2C	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DZR,PP2C_2
MMD1_k127_3612348_0	439481.Aboo_1381	5.254e-246	802.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,3F2HY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMD1_k127_3612348_3	673860.AciM339_1194	6.175e-43	174.0	COG1354@1|root,arCOG02610@2157|Archaea,2XZHK@28890|Euryarchaeota,3F2QG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMD1_k127_3612348_4	234267.Acid_6287	1.807e-31	143.0	COG1404@1|root,COG1470@1|root,COG3506@1|root,COG1404@2|Bacteria,COG1470@2|Bacteria,COG3506@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF1349)	-	-	-	-	-	-	-	-	-	-	-	-	ASH,DUF11,DUF1349,Peptidase_S8,fn3
MMD1_k127_3612348_1	717606.PaecuDRAFT_2033	2.922e-59	231.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_3612348_2	717606.PaecuDRAFT_2033	5.963e-48	180.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,1UKER@1239|Firmicutes,4HFP1@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_3619228_0	1236689.MMALV_14030	7.113e-196	625.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,3F2F6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
MMD1_k127_3619228_2	693661.Arcve_1550	3.746e-18	98.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y0SK@28890|Euryarchaeota,2476X@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMD1_k127_3619228_1	2423.NA23_0207435	2.544e-27	129.0	COG3481@1|root,COG3481@2|Bacteria,2GC74@200918|Thermotogae	200918|Thermotogae	S	nucleic acid binding OB-fold tRNA helicase-type	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
MMD1_k127_3632584_0	529709.PYCH_07400	4.654e-107	368.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMD1_k127_365906_6	649764.HMPREF0762_00259	8.497e-12	79.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CUM8@84998|Coriobacteriia	84998|Coriobacteriia	D	Belongs to the 'phage' integrase family. XerC subfamily	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMD1_k127_365906_3	1151117.AJLF01000001_gene929	6.303e-15	89.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,242ZK@183968|Thermococci	183968|Thermococci	J	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
MMD1_k127_365906_4	351627.Csac_2643	2.105e-14	76.0	COG1848@1|root,COG1848@2|Bacteria,1VBKR@1239|Firmicutes,24JHN@186801|Clostridia	186801|Clostridia	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMD1_k127_365906_5	1227484.C471_10325	7.988e-14	80.0	arCOG01449@1|root,arCOG01449@2157|Archaea,2XSVU@28890|Euryarchaeota,23T0K@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_365906_1	192952.MM_0019	3.082e-83	295.0	COG1373@1|root,arCOG03167@2157|Archaea,2XXQC@28890|Euryarchaeota,2NAAM@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMD1_k127_365906_0	1042877.GQS_03455	4.441e-131	431.0	COG1522@1|root,COG2865@1|root,arCOG01585@2157|Archaea,arCOG03296@2157|Archaea,2XTDV@28890|Euryarchaeota,245GC@183968|Thermococci	183968|Thermococci	K	Putative DNA-binding domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
MMD1_k127_3659749_0	479434.Sthe_0669	6.394e-116	386.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi,27XRG@189775|Thermomicrobia	189775|Thermomicrobia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	-	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMD1_k127_3659749_1	292459.STH1748	7.885e-109	374.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
MMD1_k127_3659749_3	40492.XP_007299915.1	0.0004564	50.0	KOG1173@1|root,KOG1173@2759|Eukaryota,38DIV@33154|Opisthokonta,3NU9B@4751|Fungi,3UYTF@5204|Basidiomycota,2258V@155619|Agaricomycetes,3H4D0@355688|Agaricomycetes incertae sedis	4751|Fungi	DO	TPR-like protein	cut9	GO:0000151,GO:0000152,GO:0000228,GO:0000775,GO:0000785,GO:0000790,GO:0000792,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005680,GO:0005694,GO:0005720,GO:0005721,GO:0005737,GO:0005829,GO:0006275,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0007088,GO:0007346,GO:0008150,GO:0008152,GO:0008156,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009896,GO:0009987,GO:0010498,GO:0010556,GO:0010558,GO:0010564,GO:0010605,GO:0010638,GO:0010965,GO:0016567,GO:0019219,GO:0019222,GO:0019538,GO:0019941,GO:0030071,GO:0030163,GO:0030174,GO:0031145,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031331,GO:0031461,GO:0031618,GO:0031974,GO:0031981,GO:0032270,GO:0032297,GO:0032436,GO:0032446,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0045732,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045931,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051247,GO:0051603,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0060255,GO:0062033,GO:0065007,GO:0070013,GO:0070647,GO:0071704,GO:0080090,GO:0090068,GO:0090329,GO:0098687,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1903052,GO:1903364,GO:1905818,GO:1905820,GO:1990234,GO:2000104,GO:2000112,GO:2000113,GO:2001252	-	ko:K03353	ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00389	-	-	ko00000,ko00001,ko00002,ko01009,ko03036,ko04121	-	-	-	ANAPC3,TPR_1,TPR_10,TPR_12,TPR_16,TPR_2,TPR_8
MMD1_k127_3659749_2	1108849.XP_002562157.1	1.835e-10	64.0	29MKV@1|root,2RUX0@2759|Eukaryota,39W60@33154|Opisthokonta,3P1P2@4751|Fungi,3RKWN@4890|Ascomycota,20U3Z@147545|Eurotiomycetes,3S55P@5042|Eurotiales	4751|Fungi	S	Ubiquitin 3 binding protein But2 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	But2
MMD1_k127_3663060_1	309807.SRU_2485	7.816e-132	432.0	COG2317@1|root,COG2317@2|Bacteria,4NK5Q@976|Bacteroidetes,1FISH@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
MMD1_k127_3663060_3	667014.Thein_1484	1.86e-37	153.0	COG0563@1|root,COG0563@2|Bacteria,2GGXU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
MMD1_k127_3663060_4	941449.dsx2_0725	1.329e-17	87.0	COG2204@1|root,COG2204@2|Bacteria,1RKC4@1224|Proteobacteria,42SJ3@68525|delta/epsilon subdivisions,2WPI1@28221|Deltaproteobacteria,2MGHJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMD1_k127_3663060_5	439481.Aboo_0646	7.165e-15	85.0	COG1522@1|root,arCOG01580@2157|Archaea,2Y746@28890|Euryarchaeota,3F3D8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD1_k127_3663060_7	380703.AHA_2463	1.995e-05	59.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria,1RS2I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3663060_6	351160.RCIX659	1.709e-07	65.0	arCOG03439@1|root,arCOG06738@1|root,arCOG03439@2157|Archaea,arCOG06738@2157|Archaea	2157|Archaea	O	extracellular matrix structural constituent	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	Beta_helix,CARDB,Calx-beta,CarboxypepD_reg,F5_F8_type_C,NosD,Peptidase_S8
MMD1_k127_3663060_2	1232410.KI421416_gene2685	1.456e-69	243.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WQX0@28221|Deltaproteobacteria,43W25@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	ko:K02617,ko:K08279	-	-	-	-	ko00000	-	-	-	Hexapep
MMD1_k127_3663060_0	1120973.AQXL01000114_gene713	1.146e-153	503.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,2783E@186823|Alicyclobacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMD1_k127_3665754_2	273116.14324649	4.13e-27	121.0	arCOG03678@1|root,arCOG03677@2157|Archaea,2Y0K5@28890|Euryarchaeota,242AH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3665754_3	404589.Anae109_1180	1.985e-25	110.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2Z0IS@29|Myxococcales	28221|Deltaproteobacteria	P	CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
MMD1_k127_3665754_1	269797.Mbar_A3612	2.244e-41	166.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
MMD1_k127_3665754_6	673860.AciM339_1041	2.955e-11	69.0	arCOG03672@1|root,arCOG08126@1|root,arCOG03672@2157|Archaea,arCOG08126@2157|Archaea,2Y73H@28890|Euryarchaeota,3F3BZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
MMD1_k127_3665754_7	673860.AciM339_1041	1.253e-10	68.0	arCOG03672@1|root,arCOG08126@1|root,arCOG03672@2157|Archaea,arCOG08126@2157|Archaea,2Y73H@28890|Euryarchaeota,3F3BZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
MMD1_k127_3665754_4	673860.AciM339_1041	1.369e-15	86.0	arCOG03672@1|root,arCOG08126@1|root,arCOG03672@2157|Archaea,arCOG08126@2157|Archaea,2Y73H@28890|Euryarchaeota,3F3BZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
MMD1_k127_3665754_5	523850.TON_1230	1.278e-13	72.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota,244GA@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
MMD1_k127_3665754_0	384616.Pisl_1934	1.11e-90	321.0	COG0063@1|root,arCOG00018@2157|Archaea,2XPXN@28889|Crenarchaeota	28889|Crenarchaeota	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMD1_k127_3701598_0	797303.Natpe_2401	2.654e-26	123.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,23SUU@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
MMD1_k127_3701598_1	1297742.A176_06972	9.825e-07	62.0	COG2234@1|root,COG2234@2|Bacteria,1MXJC@1224|Proteobacteria,42RKA@68525|delta/epsilon subdivisions,2WUCM@28221|Deltaproteobacteria,2YWU8@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	3.4.11.10	ko:K05994	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
MMD1_k127_3710085_0	635013.TherJR_2859	9.495e-18	98.0	COG4412@1|root,COG5184@1|root,COG5492@1|root,COG4412@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1TS5I@1239|Firmicutes,24A8Z@186801|Clostridia,261X1@186807|Peptococcaceae	186801|Clostridia	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,CHB_HEX_C_1,CW_binding_2,Cu_amine_oxidN1,RCC1,RCC1_2
MMD1_k127_3718150_1	306281.AJLK01000025_gene1702	1.642e-25	121.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G3AC@1117|Cyanobacteria	1117|Cyanobacteria	OQ	Clostripain family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,HemolysinCabind,Peptidase_C11,VCBS
MMD1_k127_3718150_2	679926.Mpet_0355	7.303e-24	105.0	COG0640@1|root,arCOG01680@2157|Archaea,2Y05Q@28890|Euryarchaeota,2NA1B@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
MMD1_k127_3718150_0	368407.Memar_0016	1.346e-112	375.0	COG0701@1|root,arCOG02712@2157|Archaea,2XVVT@28890|Euryarchaeota,2N9A7@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
MMD1_k127_3725163_0	479434.Sthe_2481	2.571e-34	138.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi,27XUM@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
MMD1_k127_3732731_0	1297742.A176_05132	1.154e-19	104.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
MMD1_k127_3732731_1	593105.S7A_06540	1.739e-07	65.0	COG2373@1|root,COG2911@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,3VXVZ@53335|Pantoea	1236|Gammaproteobacteria	M	PFAM FecR protein	yeeJ	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
MMD1_k127_373280_1	457396.CSBG_02639	4.65e-16	89.0	COG1512@1|root,COG1512@2|Bacteria,1V5YF@1239|Firmicutes,249DU@186801|Clostridia,36EEB@31979|Clostridiaceae	186801|Clostridia	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
MMD1_k127_373280_2	292459.STH2197	2.486e-14	87.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	CHU_C,Cadherin-like,Calx-beta,SLH,SprB
MMD1_k127_373280_0	314230.DSM3645_26769	1.526e-45	189.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	celD	-	-	ko:K20444,ko:K20543	-	-	-	-	ko00000,ko01000,ko01005,ko02000	1.B.55.3,4.D.1.3	GT2,GT4	-	Acetyltransf_6,BCSC_C,Glyco_transf_41,TPR_16
MMD1_k127_3761397_6	1117647.M5M_14702	6.335e-07	62.0	COG3227@1|root,COG3291@1|root,COG3343@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,COG3343@2|Bacteria,1R3UF@1224|Proteobacteria,1RYBG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG3291 FOG PKD repeat	-	GO:0005575,GO:0005576	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	PKD,PPC,Peptidase_M9,Peptidase_M9_N
MMD1_k127_3761397_1	273116.14324745	6.158e-106	357.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,241MF@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoglycerate kinase activity	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMD1_k127_3761397_3	926690.KE386573_gene2065	3.169e-43	175.0	COG1893@1|root,arCOG04139@2157|Archaea,2XTBD@28890|Euryarchaeota,23T98@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
MMD1_k127_3761397_5	28072.Nos7524_5484	4.824e-27	130.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
MMD1_k127_3761397_4	673860.AciM339_0553	7.552e-31	126.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZY2@28890|Euryarchaeota,3F3G3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD1_k127_3761397_0	593750.Metfor_2077	1.092e-144	466.0	COG0306@1|root,arCOG02267@2157|Archaea,2XSUU@28890|Euryarchaeota,2N9TT@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM phosphate transporter	pitA	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
MMD1_k127_3761397_2	368407.Memar_1039	1.137e-45	173.0	COG1392@1|root,arCOG02640@2157|Archaea	2157|Archaea	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
MMD1_k127_3763470_1	991905.SL003B_3564	1.327e-29	139.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_3763470_2	1001530.BACE01000028_gene3893	1.898e-06	59.0	COG1143@1|root,COG1143@2|Bacteria,1R9YT@1224|Proteobacteria,1RQB1@1236|Gammaproteobacteria,1XWMI@135623|Vibrionales	135623|Vibrionales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7
MMD1_k127_3768616_1	552811.Dehly_0331	9.262e-125	421.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMD1_k127_3768616_0	926569.ANT_01290	4.57e-141	453.0	COG0863@1|root,COG0863@2|Bacteria,2G650@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
MMD1_k127_3768616_3	485913.Krac_2038	6.346e-73	258.0	COG0667@1|root,COG0667@2|Bacteria,2G6QZ@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMD1_k127_3768616_2	485913.Krac_2038	1.67e-77	272.0	COG0667@1|root,COG0667@2|Bacteria,2G6QZ@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMD1_k127_3768616_7	566461.SSFG_06373	1.625e-07	64.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3768616_4	362976.HQ_3544A	7.655e-46	181.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,24182@183963|Halobacteria	183963|Halobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_3768616_5	378806.STAUR_6974	6.691e-15	87.0	COG0438@1|root,COG0438@2|Bacteria,1MVB4@1224|Proteobacteria,42TB1@68525|delta/epsilon subdivisions,2WRAQ@28221|Deltaproteobacteria,2YZ64@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	2.4.1.348	ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMD1_k127_3768616_6	1293054.HSACCH_02001	2.223e-08	67.0	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,3WA98@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM stage V sporulation protein B	-	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt,Polysacc_synt_C
MMD1_k127_3786472_0	591019.Shell_0491	5.551e-48	198.0	COG0515@1|root,COG2319@1|root,arCOG03270@1|root,arCOG02491@2157|Archaea,arCOG03270@2157|Archaea,arCOG03682@2157|Archaea,2XQUK@28889|Crenarchaeota	28889|Crenarchaeota	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMD1_k127_3799127_6	1120983.KB894574_gene808	5.791e-24	112.0	COG0596@1|root,COG0596@2|Bacteria,1PFTV@1224|Proteobacteria,2V8R3@28211|Alphaproteobacteria,1JQG3@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Thioesterase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3799127_0	351160.RRC285	1.053e-82	291.0	COG0598@1|root,arCOG02265@2157|Archaea	2157|Archaea	P	Mediates influx of magnesium ions	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMD1_k127_3799127_2	351160.RRC153	6.872e-69	243.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N9E2@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroF	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0920	DeoC
MMD1_k127_3799127_3	679926.Mpet_2704	4.804e-64	234.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
MMD1_k127_3799127_4	755731.Clo1100_1902	2.101e-40	163.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,36W9X@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
MMD1_k127_3799127_1	192952.MM_1712	4.19e-81	289.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
MMD1_k127_3799127_5	1123322.KB904650_gene1887	2.32e-40	171.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
MMD1_k127_383671_0	1121396.KB892900_gene2131	1.907e-40	167.0	COG1657@1|root,COG1657@2|Bacteria,1RDNW@1224|Proteobacteria,42S7H@68525|delta/epsilon subdivisions,2WNQX@28221|Deltaproteobacteria,2MMUB@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	Prenyltrans
MMD1_k127_383671_1	234831.PSM_A0230	8.721e-12	78.0	COG0745@1|root,COG3292@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3292@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,2Q5HG@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GAF_2,GGDEF,HAMP,HATPase_c,HTH_18,HisKA,Hpt,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Phosphonate-bd,Reg_prop,Response_reg,TarH,Y_Y_Y
MMD1_k127_385494_1	1041930.Mtc_0700	2.104e-24	117.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMD1_k127_385494_0	1041930.Mtc_0068	1.905e-53	193.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMD1_k127_385494_3	797114.C475_10494	4.829e-12	69.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota,23WVW@183963|Halobacteria	183963|Halobacteria	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1B	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
MMD1_k127_385494_2	1236689.MMALV_00680	4.387e-13	71.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y6XW@28890|Euryarchaeota,3F2UA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMD1_k127_3858542_3	439481.Aboo_1130	1.142e-16	83.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,3F2H2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMD1_k127_3858542_7	1235796.C815_01121	3.734e-08	62.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
MMD1_k127_3858542_9	1313421.JHBV01000176_gene854	4.633e-05	46.0	2DPX5@1|root,333S8@2|Bacteria,4NXW9@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3858542_2	596152.DesU5LDRAFT_2681	2.653e-20	91.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3858542_8	240292.Ava_0880	2.884e-05	59.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1HMYH@1161|Nostocales	1117|Cyanobacteria	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
MMD1_k127_3858542_4	880073.Calab_0674	1.57e-15	93.0	COG1520@1|root,COG2911@1|root,COG3420@1|root,COG1520@2|Bacteria,COG2911@2|Bacteria,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	4.2.2.3	ko:K01729,ko:K17713	ko00051,map00051	-	R03706	-	ko00000,ko00001,ko01000,ko02000	1.B.33.1	-	-	Beta_helix,Big_4,CHU_C,CarboxypepD_reg,DUF5050,HYR,Peptidase_S8,SprB
MMD1_k127_3858542_0	1236689.MMALV_09870	1.66e-119	395.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,3F2FZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Toprim domain	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMD1_k127_3872516_1	1123054.KB907711_gene361	9.542e-15	82.0	COG1404@1|root,COG3266@1|root,COG1404@2|Bacteria,COG3266@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMD1_k127_3872516_0	1033806.HTIA_0248	8.971e-41	167.0	COG1226@1|root,arCOG01958@2157|Archaea,2XT46@28890|Euryarchaeota,23SFI@183963|Halobacteria	183963|Halobacteria	P	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
MMD1_k127_3889468_3	548477.HMPREF0294_0332	7.955e-34	151.0	COG2885@1|root,COG3266@1|root,COG2885@2|Bacteria,COG3266@2|Bacteria,2I6XH@201174|Actinobacteria,22MTB@1653|Corynebacteriaceae	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,TSP_3,YSIRK_signal
MMD1_k127_3889468_0	926550.CLDAP_28350	6.834e-67	261.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
MMD1_k127_3889468_5	1123054.KB907711_gene361	5.128e-21	110.0	COG1404@1|root,COG3266@1|root,COG1404@2|Bacteria,COG3266@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMD1_k127_3889468_1	1236689.MMALV_00620	4.217e-45	181.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,3F2ME@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.39,2.7.8.5	ko:K00995,ko:K17884	ko00564,ko01100,map00564,map01100	-	R01801,R10464	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1250	CDP-OH_P_transf
MMD1_k127_3889468_4	348780.NP_2142A	2.369e-25	114.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,23VP9@183963|Halobacteria	183963|Halobacteria	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	adk2	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMD1_k127_3889468_2	1236689.MMALV_10930	1.372e-42	172.0	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,3F2MU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Domain in cystathionine beta-synthase and other proteins.	cbs1	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD1_k127_3914124_0	1379698.RBG1_1C00001G0054	4.215e-184	580.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
MMD1_k127_3914124_1	1236689.MMALV_11680	1.132e-40	164.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y6XJ@28890|Euryarchaeota,3F2QT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	dUTPase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
MMD1_k127_3914124_3	673860.AciM339_1185	4.225e-15	87.0	COG0727@1|root,arCOG02579@2157|Archaea,2Y1J3@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMD1_k127_3914124_2	1463858.JOHR01000025_gene4092	4.636e-35	151.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	-	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMD1_k127_3923335_0	1198114.AciX9_2489	2.205e-37	161.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	wcoG	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,PKD
MMD1_k127_3938964_0	1298593.TOL_1324	4.376e-10	74.0	COG3209@1|root,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,1XMP6@135619|Oceanospirillales	135619|Oceanospirillales	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
MMD1_k127_3952843_1	697281.Mahau_1114	3.04e-06	61.0	COG2730@1|root,COG4733@1|root,COG2730@2|Bacteria,COG4733@2|Bacteria,1TT6J@1239|Firmicutes,24CXA@186801|Clostridia	186801|Clostridia	G	hydrolase family 5	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_X2,Cellulase
MMD1_k127_3952843_0	309799.DICTH_1324	3.267e-187	596.0	COG0060@1|root,COG0060@2|Bacteria	2|Bacteria	J	isoleucyl-tRNA aminoacylation	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD1_k127_3964526_0	673860.AciM339_1396	1.299e-136	452.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,3F2HC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Radical_SAM C-terminal domain	elp3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
MMD1_k127_3964526_3	186497.PF0102	2.398e-10	70.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_3964526_2	765911.Thivi_4504	3.486e-59	217.0	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,1RUHP@1236|Gammaproteobacteria,1WXXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HhH-GPD	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
MMD1_k127_3964526_1	195522.BD01_1939	3.806e-70	256.0	COG2262@1|root,arCOG00353@2157|Archaea,2XT2W@28890|Euryarchaeota,2431W@183968|Thermococci	183968|Thermococci	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
MMD1_k127_3966972_0	234267.Acid_5088	1.955e-203	644.0	COG1012@1|root,COG1012@2|Bacteria,3Y3CY@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMD1_k127_3966972_2	1379698.RBG1_1C00001G0675	6.258e-104	351.0	COG1748@1|root,COG1748@2|Bacteria,2NPF8@2323|unclassified Bacteria	2|Bacteria	E	Saccharopine dehydrogenase C-terminal domain	lysDH	-	1.4.1.18	ko:K19064	ko00960,ko01100,ko01110,map00960,map01100,map01110	-	R00446,R02317	RC00062,RC00694	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
MMD1_k127_3966972_4	1440774.Y900_023830	2.135e-05	54.0	2DPNA@1|root,332RJ@2|Bacteria,2I2PY@201174|Actinobacteria,239ME@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
MMD1_k127_3966972_1	706587.Desti_0486	3.756e-132	431.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42SJQ@68525|delta/epsilon subdivisions,2WPH7@28221|Deltaproteobacteria,2MRF5@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMD1_k127_3966972_3	1047013.AQSP01000037_gene1326	3.781e-92	308.0	COG1830@1|root,COG1830@2|Bacteria,2NPYC@2323|unclassified Bacteria	2|Bacteria	G	DeoC/LacD family aldolase	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245,4.1.2.13	ko:K08321,ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMD1_k127_3968973_2	938289.CAJN020000002_gene489	5.73e-41	163.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,268D2@186813|unclassified Clostridiales	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
MMD1_k127_3968973_3	673860.AciM339_0975	6.818e-32	135.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,3F2TB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	RNA-binding protein of the translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
MMD1_k127_3968973_1	224325.AF_2298	1.537e-83	287.0	COG1467@1|root,arCOG04110@2157|Archaea,2Y7DK@28890|Euryarchaeota,246SV@183980|Archaeoglobi	183980|Archaeoglobi	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3968973_0	909663.KI867150_gene2868	0.0	1017.0	COG0369@1|root,COG1151@2|Bacteria,1NRXN@1224|Proteobacteria,42Y5Y@68525|delta/epsilon subdivisions,2WUG6@28221|Deltaproteobacteria,2MSJ9@213462|Syntrophobacterales	2|Bacteria	P	Prismane/CO dehydrogenase family	cooS	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
MMD1_k127_3968973_4	673860.AciM339_1421	6.288e-27	111.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,3F2ID@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	helicase superfamily c-terminal domain	hef	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
MMD1_k127_3979982_1	1968.JOEV01000045_gene2266	3.368e-06	61.0	COG4733@1|root,COG4733@2|Bacteria,2HCWC@201174|Actinobacteria	201174|Actinobacteria	Q	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14
MMD1_k127_3979982_0	335543.Sfum_0444	1.561e-18	102.0	COG3218@1|root,COG3218@2|Bacteria,1QWQA@1224|Proteobacteria,42VJ7@68525|delta/epsilon subdivisions,2WS0Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ethylbenzene dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	EB_dh
MMD1_k127_3990344_0	1122176.KB903598_gene4713	5.083e-21	98.0	2F03P@1|root,33T7B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_3990344_2	383372.Rcas_2574	7.142e-06	59.0	COG1572@1|root,COG3386@1|root,COG1572@2|Bacteria,COG3386@2|Bacteria,2G9CG@200795|Chloroflexi,374U7@32061|Chloroflexia	32061|Chloroflexia	G	LamG domain protein jellyroll fold domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,Laminin_G_3
MMD1_k127_3990344_1	374847.Kcr_0727	1.542e-09	61.0	COG3291@1|root,arCOG02508@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Malectin,PKD
MMD1_k127_4001331_2	375286.mma_1769	1.627e-14	83.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,476AB@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	czcA	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
MMD1_k127_4001331_0	391623.TERMP_00726	1.057e-163	527.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,242RZ@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMD1_k127_4001331_3	673860.AciM339_0336	1.749e-06	55.0	arCOG05340@1|root,arCOG05340@2157|Archaea,2Y77S@28890|Euryarchaeota,3F3IY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4001331_1	673860.AciM339_0863	1.233e-134	443.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,3F2II@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMD1_k127_4009218_0	439481.Aboo_0004	1.856e-58	226.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,3F2M6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Arginase family	speB	GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMD1_k127_4009218_2	673860.AciM339_0003	1.275e-44	171.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,3F2PU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMD1_k127_4009218_1	673860.AciM339_0972	2.294e-49	189.0	COG0483@1|root,arCOG01349@2157|Archaea,2Y87S@28890|Euryarchaeota,3F2MR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
MMD1_k127_4010986_0	999630.TUZN_2126	2.956e-13	71.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMD1_k127_4010986_1	1463820.JOGW01000002_gene6394	0.0003293	54.0	COG0791@1|root,COG2385@1|root,COG2755@1|root,COG3209@1|root,COG0791@2|Bacteria,COG2385@2|Bacteria,COG2755@2|Bacteria,COG3209@2|Bacteria,2GK5H@201174|Actinobacteria	201174|Actinobacteria	E	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,Ricin_B_lectin,VCBS
MMD1_k127_4022802_0	1125863.JAFN01000001_gene1627	4.03e-45	171.0	COG1145@1|root,COG1943@1|root,COG1145@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
MMD1_k127_4051100_1	345219.Bcoa_1579	2.367e-05	46.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,1ZQ3I@1386|Bacillus	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMD1_k127_4051100_0	926569.ANT_07500	8.222e-16	93.0	COG1470@1|root,COG2374@1|root,COG1470@2|Bacteria,COG2374@2|Bacteria,2G82K@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Endonuclease exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_5,Exo_endo_phos,LTD
MMD1_k127_4072739_2	589924.Ferp_1508	3.386e-17	84.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota,246HY@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMD1_k127_4072739_0	693661.Arcve_1173	2.91e-248	792.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,245S4@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMD1_k127_4072739_1	439481.Aboo_0654	6.555e-72	271.0	arCOG00373@1|root,arCOG02452@1|root,arCOG00373@2157|Archaea,arCOG02452@2157|Archaea,2Y71H@28890|Euryarchaeota,3F35U@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_4080978_8	1278309.KB907099_gene2425	0.0005853	52.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,1RPW5@1236|Gammaproteobacteria,1XJM4@135619|Oceanospirillales	135619|Oceanospirillales	H	1,4-dihydroxy-2-naphthoate octaprenyltransferase	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_4080978_6	326424.FRAAL2863	3.558e-17	94.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4EXBT@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_4080978_7	926569.ANT_07650	2.773e-14	85.0	COG0577@1|root,COG0577@2|Bacteria,2G65B@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_4080978_1	1219084.AP014508_gene646	3.2e-70	246.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_4080978_4	1042877.GQS_03500	1.213e-36	147.0	COG0561@1|root,arCOG01213@2157|Archaea,2XX94@28890|Euryarchaeota,242JB@183968|Thermococci	183968|Thermococci	G	Catalyzes the dephosphorylation of 2-phosphoglycolate	-	-	3.1.3.18	ko:K22223	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	Hydrolase_3
MMD1_k127_4080978_0	1220534.B655_1784	5.446e-100	341.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,23PD9@183925|Methanobacteria	183925|Methanobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
MMD1_k127_4080978_2	580340.Tlie_1563	4.448e-55	197.0	COG0066@1|root,COG0066@2|Bacteria,3TAD5@508458|Synergistetes	508458|Synergistetes	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMD1_k127_4080978_3	471854.Dfer_2050	8.286e-55	222.0	COG2831@1|root,COG2931@1|root,COG2831@2|Bacteria,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
MMD1_k127_4080978_5	644281.MFS40622_1230	3.174e-31	131.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23QUN@183939|Methanococci	183939|Methanococci	J	PFAM methyltransferase small	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,PrmA
MMD1_k127_4082152_0	1123508.JH636439_gene345	4.203e-27	130.0	COG3210@1|root,COG3391@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria,2J08H@203682|Planctomycetes	203682|Planctomycetes	J	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_4103993_0	1236689.MMALV_03240	1.199e-58	231.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,3F2K0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMD1_k127_4110301_0	1246995.AFR_10685	7.548e-97	334.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4D8WS@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMD1_k127_4110301_6	862517.HMPREF9225_0406	3.856e-08	64.0	COG0011@1|root,COG0011@2|Bacteria,1VAIR@1239|Firmicutes,24NBA@186801|Clostridia,22HFT@1570339|Peptoniphilaceae	186801|Clostridia	S	Pfam PF01910	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
MMD1_k127_4110301_1	529709.PYCH_07540	6.339e-69	244.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,242XM@183968|Thermococci	183968|Thermococci	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
MMD1_k127_4110301_4	415426.Hbut_1376	8.754e-16	86.0	arCOG09415@1|root,arCOG09415@2157|Archaea,2XS53@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Reeler
MMD1_k127_4110301_8	1453500.AT05_07840	2.276e-06	59.0	2DQEZ@1|root,336F0@2|Bacteria,4NUK8@976|Bacteroidetes,1I4H2@117743|Flavobacteriia	976|Bacteroidetes	S	Reeler domain	-	-	-	-	-	-	-	-	-	-	-	-	Reeler
MMD1_k127_4110301_2	321332.CYB_0040	7.897e-59	235.0	COG0243@1|root,COG0243@2|Bacteria,1G0DW@1117|Cyanobacteria,1GYE2@1129|Synechococcus	1117|Cyanobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narB	GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114	1.7.7.2	ko:K00367	ko00910,ko01120,map00910,map01120	M00531	R00791	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
MMD1_k127_4110301_7	1009370.ALO_21174	4.357e-08	63.0	COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,4H4RE@909932|Negativicutes	909932|Negativicutes	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
MMD1_k127_4110301_5	1121468.AUBR01000023_gene2767	2.034e-15	85.0	COG1763@1|root,COG1763@2|Bacteria,1VFA0@1239|Firmicutes,24IYN@186801|Clostridia,42GXT@68295|Thermoanaerobacterales	186801|Clostridia	H	Molybdopterin-guanine dinucleotide biosynthesis protein B	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
MMD1_k127_4110301_3	267377.MMP0668	5.554e-19	94.0	COG1326@1|root,arCOG02680@2157|Archaea,2XUFW@28890|Euryarchaeota,23QUQ@183939|Methanococci	183939|Methanococci	S	archaeal Zn-finger protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-DNL
MMD1_k127_4113650_0	387631.Asulf_01816	5.736e-228	722.0	COG1148@1|root,arCOG02234@2157|Archaea,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
MMD1_k127_411572_0	1380763.BG53_12335	3.862e-59	214.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,4IPX9@91061|Bacilli,274EY@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD1_k127_411572_1	1499967.BAYZ01000158_gene470	1.872e-09	70.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMD1_k127_411572_2	1168034.FH5T_05690	0.0001198	55.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,2FMIV@200643|Bacteroidia	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
MMD1_k127_4118880_0	234267.Acid_3115	3.5e-33	149.0	COG0457@1|root,COG3710@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG3899@2|Bacteria,3Y2KZ@57723|Acidobacteria	57723|Acidobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Trans_reg_C
MMD1_k127_4123002_6	370438.PTH_1947	4.713e-19	88.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,26142@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMD1_k127_4123002_2	671143.DAMO_2134	2.349e-75	261.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	2.7.7.7,6.5.1.2	ko:K01972,ko:K02342,ko:K04096,ko:K12472	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko04144,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map04144	M00260	R00375,R00376,R00377,R00378,R00382	RC00005,RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400,ko04131	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5,RNase_T
MMD1_k127_4123002_1	760568.Desku_1684	8.541e-115	383.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,260BN@186807|Peptococcaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
MMD1_k127_4123002_5	552811.Dehly_1587	1.344e-24	111.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi,34D41@301297|Dehalococcoidia	301297|Dehalococcoidia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMD1_k127_4123002_4	1537994.JQFW01000031_gene1084	5.805e-25	123.0	COG2373@1|root,COG2911@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,465B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
MMD1_k127_4123002_3	243231.GSU2914	2.366e-27	132.0	COG3391@1|root,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria,43C5A@68525|delta/epsilon subdivisions,2WNBK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4123002_0	1236689.MMALV_06560	2.029e-206	657.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,3F2G2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	metal-binding domain in RNase L inhibitor, RLI	rli	GO:0000166,GO:0003674,GO:0005488,GO:0005506,GO:0005524,GO:0006412,GO:0006413,GO:0006415,GO:0006518,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0017076,GO:0019538,GO:0022411,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0046872,GO:0046914,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
MMD1_k127_4123002_9	439481.Aboo_0147	2.574e-07	57.0	COG0640@1|root,arCOG03067@2157|Archaea,2Y747@28890|Euryarchaeota,3F3DB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMD1_k127_4123002_8	1236689.MMALV_12690	2.746e-08	56.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y1AH@28890|Euryarchaeota,3F2U9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
MMD1_k127_4123002_7	1157490.EL26_16675	9.496e-14	72.0	COG4191@1|root,COG4191@2|Bacteria,1UIFW@1239|Firmicutes	1239|Firmicutes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMD1_k127_4126087_0	246200.SPO0570	1.335e-07	63.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1PPWK@1224|Proteobacteria,2TYY3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
MMD1_k127_4155052_0	1054217.TALC_00116	7.648e-60	214.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,241KA@183967|Thermoplasmata	183967|Thermoplasmata	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
MMD1_k127_4155052_1	572546.Arcpr_0498	4.911e-57	202.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMD1_k127_4155052_7	565033.GACE_1329	2.201e-21	94.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,246HX@183980|Archaeoglobi	183980|Archaeoglobi	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMD1_k127_4155052_5	1054217.TALC_00113	2.675e-26	115.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,241VA@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMD1_k127_4155052_3	1151117.AJLF01000001_gene890	5.346e-40	152.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMD1_k127_4155052_4	404589.Anae109_3653	2.456e-36	148.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,43BI6@68525|delta/epsilon subdivisions,2X6WK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
MMD1_k127_4155052_8	511051.CSE_08930	6.931e-19	94.0	COG2151@1|root,COG2151@2|Bacteria	2|Bacteria	L	metal-sulfur cluster biosynthetic enzyme	-	-	-	ko:K02612,ko:K04488	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
MMD1_k127_4155052_6	589924.Ferp_0134	5.263e-23	110.0	COG3413@1|root,arCOG02271@2157|Archaea,2XU8X@28890|Euryarchaeota	28890|Euryarchaeota	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,HTH_10
MMD1_k127_4155052_2	443144.GM21_1393	4.181e-40	157.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,42MZG@68525|delta/epsilon subdivisions,2WKZ3@28221|Deltaproteobacteria,43UBA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
MMD1_k127_4176774_2	673860.AciM339_0749	2.736e-68	256.0	COG0517@1|root,COG0750@1|root,arCOG00607@2157|Archaea,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,3F2KK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
MMD1_k127_4176774_6	1236689.MMALV_13580	2.505e-20	92.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,3F2SB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	snRNP Sm proteins	lsm	GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMD1_k127_4176774_7	634498.mru_1281	8.892e-15	77.0	COG2126@1|root,arCOG04126@2157|Archaea,2XZUV@28890|Euryarchaeota,23P7A@183925|Methanobacteria	183925|Methanobacteria	J	binds to the 23S rRNA	rpl37e	-	-	ko:K02922	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37e
MMD1_k127_4176774_0	1236689.MMALV_13560	1.514e-145	475.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,3F2FP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMD1_k127_4176774_1	498761.HM1_1842	9.36e-80	280.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMD1_k127_4176774_8	1094980.Mpsy_1955	4.39e-12	73.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
MMD1_k127_4176774_9	399549.Msed_1416	4.522e-05	49.0	COG2104@1|root,arCOG00535@2157|Archaea	2157|Archaea	H	Sulfur transfer protein involved in thiamine biosynthesis	samp2	GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564	2.8.1.15	ko:K03154,ko:K21947	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiS
MMD1_k127_4176774_4	439481.Aboo_1281	3.64e-44	184.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,3F2NS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	K homology RNA-binding domain	dim2	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
MMD1_k127_4176774_3	304371.MCP_1531	1.948e-61	224.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
MMD1_k127_4176774_5	1242864.D187_000395	2.032e-24	122.0	COG2706@1|root,COG2931@1|root,COG2706@2|Bacteria,COG2931@2|Bacteria,1RB92@1224|Proteobacteria	1224|Proteobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_4184460_2	349521.HCH_02073	2.343e-10	74.0	COG1372@1|root,COG3209@1|root,COG1372@2|Bacteria,COG3209@2|Bacteria,1QW4H@1224|Proteobacteria,1T42N@1236|Gammaproteobacteria,1XMP6@135619|Oceanospirillales	135619|Oceanospirillales	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
MMD1_k127_4184460_1	457570.Nther_0880	4.426e-40	161.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5
MMD1_k127_4184460_0	1041930.Mtc_0274	5.876e-171	547.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota	28890|Euryarchaeota	I	Belongs to the HMG-CoA reductase family	hmgA-1	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
MMD1_k127_418718_0	1150399.AQYK01000002_gene3209	4.044e-17	96.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4FKX3@85023|Microbacteriaceae	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
MMD1_k127_4189807_4	304371.MCP_0978	1.505e-23	105.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y74T@28890|Euryarchaeota,2NBB7@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMD1_k127_4189807_1	351160.RRC295	5.338e-42	163.0	COG4802@1|root,arCOG01099@2157|Archaea	2157|Archaea	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3422,FeThRed_B,Glutaredoxin
MMD1_k127_4189807_5	304371.MCP_0976	3.621e-23	103.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y25G@28890|Euryarchaeota	28890|Euryarchaeota	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
MMD1_k127_4189807_3	304371.MCP_0975	3.885e-29	119.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y72M@28890|Euryarchaeota,2NB71@224756|Methanomicrobia	224756|Methanomicrobia	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMD1_k127_4189807_2	673860.AciM339_1234	4.051e-35	139.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,3F2RM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
MMD1_k127_4189807_0	909663.KI867150_gene2911	1.637e-150	485.0	COG0006@1|root,COG0006@2|Bacteria,1QNPN@1224|Proteobacteria,431BA@68525|delta/epsilon subdivisions,2WW9X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
MMD1_k127_4189807_7	1225184.ALXE01000031_gene4273	8.2e-14	85.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,3W1I8@53335|Pantoea	1236|Gammaproteobacteria	Q	von willebrand factor, type A	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD1_k127_4189807_6	439481.Aboo_1307	1.124e-22	105.0	arCOG05357@1|root,arCOG05357@2157|Archaea,2Y1B1@28890|Euryarchaeota,3F2VN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4189807_8	44056.XP_009043122.1	9.837e-06	57.0	COG3914@1|root,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
MMD1_k127_4190116_5	1054217.TALC_00187	3.038e-14	74.0	COG1986@1|root,arCOG01221@2157|Archaea,2Y53C@28890|Euryarchaeota	28890|Euryarchaeota	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4190116_2	1457250.BBMO01000001_gene1581	2.926e-65	258.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_4190116_6	693977.Deipr_0149	7.809e-14	87.0	COG1404@1|root,COG1404@2|Bacteria,1WKW6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	S53, subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMD1_k127_4190116_7	697282.Mettu_3886	0.000155	57.0	COG1749@1|root,COG2319@1|root,COG2372@1|root,COG1749@2|Bacteria,COG2319@2|Bacteria,COG2372@2|Bacteria,1MWJA@1224|Proteobacteria,1S1AJ@1236|Gammaproteobacteria,1XF66@135618|Methylococcales	135618|Methylococcales	N	WD40 repeat, subgroup	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,WD40
MMD1_k127_4190116_3	410358.Mlab_1687	2.82e-39	153.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
MMD1_k127_4190116_1	292564.Cyagr_1719	2.427e-85	293.0	COG3384@1|root,COG3384@2|Bacteria,1GJVU@1117|Cyanobacteria,22TV8@167375|Cyanobium	1117|Cyanobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
MMD1_k127_4190116_4	1121468.AUBR01000020_gene2848	5.078e-36	143.0	COG1611@1|root,COG1611@2|Bacteria,1V2D7@1239|Firmicutes,24KYJ@186801|Clostridia,42HB2@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM TIGR00725 family protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
MMD1_k127_4190116_0	456442.Mboo_1864	1.642e-96	326.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N9HU@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
MMD1_k127_4194914_2	1219084.AP014508_gene114	5.743e-24	110.0	COG1656@1|root,COG1656@2|Bacteria,2GDIT@200918|Thermotogae	200918|Thermotogae	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMD1_k127_4194914_1	439481.Aboo_0416	2.359e-43	168.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,3F2MK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	ribG	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
MMD1_k127_4194914_0	673860.AciM339_0285	1.682e-67	251.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMD1_k127_4194914_3	1122223.KB890687_gene2570	9.528e-06	58.0	COG1470@1|root,COG4719@1|root,COG1470@2|Bacteria,COG4719@2|Bacteria,1WJNZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_423979_0	368408.Tpen_0602	4.017e-127	427.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
MMD1_k127_423979_1	583355.Caka_1050	8.319e-26	125.0	COG0857@1|root,COG0857@2|Bacteria,46UEZ@74201|Verrucomicrobia,3K761@414999|Opitutae	414999|Opitutae	C	AAA domain	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
MMD1_k127_423979_2	518766.Rmar_1279	1.593e-22	106.0	COG1321@1|root,COG1321@2|Bacteria,4NGUP@976|Bacteroidetes,1FK7U@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	FeoA	sirR	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
MMD1_k127_423979_3	1304866.K413DRAFT_5077	8.589e-13	82.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,36DEB@31979|Clostridiaceae	186801|Clostridia	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
MMD1_k127_4242695_0	673860.AciM339_0019	1.402e-11	79.0	COG0457@1|root,arCOG02493@1|root,arCOG02493@2157|Archaea,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	HTH_24,PQQ_2,PQQ_3,TPR_12,TPR_16,TPR_2,TPR_8
MMD1_k127_4242695_2	439481.Aboo_0163	2.344e-05	58.0	arCOG08231@1|root,arCOG08231@2157|Archaea	2157|Archaea	L	Micrococcal nuclease (thermonuclease) homologs	-	-	3.1.31.1	ko:K01174,ko:K02238	-	M00429	-	-	ko00000,ko00002,ko01000,ko02044	3.A.11.1,3.A.11.2	-	-	LTD,Lactamase_B,PhoD,SNase
MMD1_k127_4242695_1	1121920.AUAU01000021_gene2521	3.932e-07	61.0	COG3809@1|root,COG3809@2|Bacteria,3Y803@57723|Acidobacteria	57723|Acidobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-TFIIB
MMD1_k127_4251312_0	1220534.B655_0025	7.869e-05	51.0	COG1531@1|root,arCOG01302@2157|Archaea	2157|Archaea	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
MMD1_k127_4255574_0	348780.NP_5062A	1.595e-39	169.0	COG1520@1|root,arCOG02556@2157|Archaea,2Y7Q9@28890|Euryarchaeota,240XC@183963|Halobacteria	183963|Halobacteria	C	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
MMD1_k127_4255574_1	246197.MXAN_1605	2.42e-07	63.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42NUK@68525|delta/epsilon subdivisions,2WJTJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_4275269_4	671143.DAMO_2613	1.558e-07	56.0	COG1011@1|root,COG1011@2|Bacteria,2NQ1K@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.3.102,3.1.3.104,3.8.1.2	ko:K01560,ko:K07025,ko:K20862	ko00361,ko00625,ko00740,ko01100,ko01110,ko01120,map00361,map00625,map00740,map01100,map01110,map01120	M00125	R00548,R05287,R07280	RC00017,RC00697	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
MMD1_k127_4275269_0	269797.Mbar_A3266	3.005e-42	163.0	COG0778@1|root,arCOG00288@2157|Archaea,2Y6YN@28890|Euryarchaeota,2NB04@224756|Methanomicrobia	224756|Methanomicrobia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMD1_k127_4275269_2	1347392.CCEZ01000015_gene2772	9.829e-31	131.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,36FKV@31979|Clostridiaceae	186801|Clostridia	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMD1_k127_4275269_3	1118054.CAGW01000089_gene3463	5.718e-21	108.0	COG2234@1|root,COG2234@2|Bacteria,1UFM1@1239|Firmicutes,4HCR1@91061|Bacilli,27690@186822|Paenibacillaceae	91061|Bacilli	S	Peptidase family M28	ywaD	-	3.4.11.10,3.4.11.6	ko:K19701	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28
MMD1_k127_4275269_1	316067.Geob_3326	4.148e-33	149.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PQZ@68525|delta/epsilon subdivisions,2WMD9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Hemolysin-type calcium-binding	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,HCBP_related,He_PIG,HemolysinCabind,Peptidase_M91,VWA_2
MMD1_k127_4275269_5	247490.KSU1_D0057	7.398e-05	52.0	COG1633@1|root,COG1633@2|Bacteria,2J3U9@203682|Planctomycetes	203682|Planctomycetes	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMD1_k127_427693_2	439481.Aboo_0815	2.42e-19	98.0	COG1277@1|root,arCOG03689@2157|Archaea,2Y0MI@28890|Euryarchaeota,3F2VX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMD1_k127_427693_1	1236689.MMALV_14690	2.686e-63	230.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7KH@28890|Euryarchaeota	28890|Euryarchaeota	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_427693_0	456442.Mboo_1172	4.242e-225	765.0	COG0457@1|root,arCOG03048@1|root,arCOG03032@2157|Archaea,arCOG03038@2157|Archaea,arCOG03048@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAF9@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
MMD1_k127_427693_3	693661.Arcve_1632	2.336e-13	75.0	COG2018@1|root,arCOG02603@2157|Archaea,2XY6Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
MMD1_k127_427693_4	1455608.JDTH01000002_gene1501	1.238e-07	64.0	COG0025@1|root,arCOG01961@2157|Archaea,2XT52@28890|Euryarchaeota,23SVP@183963|Halobacteria	183963|Halobacteria	P	COG0025 NhaP-type Na H and K H antiporters	kef1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
MMD1_k127_4288627_1	870187.Thini_1774	5.925e-11	75.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMD1_k127_4288627_0	439235.Dalk_2289	7.793e-14	83.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1MWIT@1224|Proteobacteria,42W2M@68525|delta/epsilon subdivisions,2WRTW@28221|Deltaproteobacteria,2MKVR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,VCBS
MMD1_k127_4292530_1	368407.Memar_1073	2.032e-51	192.0	arCOG02449@1|root,arCOG02449@2157|Archaea,2XZ1K@28890|Euryarchaeota,2NAXS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMD1_k127_4292530_2	706587.Desti_0743	1.792e-14	78.0	COG0720@1|root,COG0720@2|Bacteria	2|Bacteria	H	synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMD1_k127_4292530_0	926550.CLDAP_31600	2.049e-97	334.0	COG1063@1|root,COG1063@2|Bacteria,2G6FN@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
MMD1_k127_4292530_3	1192034.CAP_2166	7.216e-13	68.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,42PUK@68525|delta/epsilon subdivisions,2WIN4@28221|Deltaproteobacteria,2YU7Y@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMD1_k127_4309454_0	1121013.P873_07465	1.204e-34	140.0	COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,1S5G6@1236|Gammaproteobacteria,1X6C8@135614|Xanthomonadales	135614|Xanthomonadales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMD1_k127_4309454_1	1121920.AUAU01000039_gene1425	2.459e-09	68.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.1.3.5,3.2.1.14	ko:K01081,ko:K01183,ko:K20276	ko00230,ko00240,ko00520,ko00760,ko01100,ko01110,ko02024,map00230,map00240,map00520,map00760,map01100,map01110,map02024	-	R00183,R00511,R00963,R01126,R01206,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02334,R02719,R03346	RC00017,RC00467	ko00000,ko00001,ko01000	-	GH18	-	F5_F8_type_C,Melibiase_2,NPCBM_assoc,PKD,PPC,Trypsin_2,VPEP
MMD1_k127_4309681_0	1047013.AQSP01000125_gene2640	4.124e-124	413.0	COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
MMD1_k127_4309681_1	1210908.HSB1_18760	1.319e-11	76.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XWRN@28890|Euryarchaeota,23VH4@183963|Halobacteria	183963|Halobacteria	K	DNA binding	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMD1_k127_4309681_2	588581.Cpap_0145	4.578e-06	60.0	COG2041@1|root,COG3210@1|root,COG2041@2|Bacteria,COG3210@2|Bacteria,1TPWY@1239|Firmicutes,25EVA@186801|Clostridia	186801|Clostridia	U	PFAM S-layer	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMD1_k127_4327567_3	398512.JQKC01000032_gene4456	7.996e-20	94.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,24K4J@186801|Clostridia,3WKGY@541000|Ruminococcaceae	186801|Clostridia	J	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
MMD1_k127_4327567_2	1232410.KI421427_gene1293	7.564e-23	99.0	COG2361@1|root,COG2361@2|Bacteria,1PTAQ@1224|Proteobacteria,42XY1@68525|delta/epsilon subdivisions,2X5B6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
MMD1_k127_4327567_1	386456.JQKN01000002_gene2525	4.675e-26	110.0	COG1669@1|root,arCOG01206@2157|Archaea,2Y02Z@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD1_k127_4327567_0	931626.Awo_c20800	8.476e-43	168.0	COG0655@1|root,COG0655@2|Bacteria,1UI36@1239|Firmicutes,247R8@186801|Clostridia	186801|Clostridia	E	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD1_k127_4341056_3	439481.Aboo_0655	2.332e-09	61.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,3F2H7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	LT	Protein kinase domain	kae1	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234,2.7.11.1	ko:K08851,ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,Pkinase,RIO1
MMD1_k127_4341056_2	693661.Arcve_0149	7.383e-15	89.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD1_k127_4341056_0	1094980.Mpsy_2341	8.089e-249	797.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMD1_k127_4341056_1	604354.TSIB_1549	1.579e-52	198.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,242X5@183968|Thermococci	183968|Thermococci	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD1_k127_434603_8	666510.ASAC_1278	3.817e-56	208.0	COG1838@1|root,arCOG04406@2157|Archaea,2XQ9V@28889|Crenarchaeota	28889|Crenarchaeota	C	Fe-S type, tartrate fumarate subfamily, beta	-	-	4.2.1.2,4.2.1.32	ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
MMD1_k127_434603_2	351160.RCIX2057	9.135e-89	328.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,2N9FT@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
MMD1_k127_434603_12	1343739.PAP_03060	1.95e-19	98.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2431D@183968|Thermococci	183968|Thermococci	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
MMD1_k127_434603_11	197221.22295264	6.268e-20	102.0	COG0382@1|root,COG0382@2|Bacteria,1G2BD@1117|Cyanobacteria	1117|Cyanobacteria	H	Chlorophyll synthase, ChlG	chlG	-	2.5.1.133,2.5.1.62	ko:K04040	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	iJN678.chlG	UbiA
MMD1_k127_434603_5	1054217.TALC_00158	2.717e-75	262.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,241NA@183967|Thermoplasmata	183967|Thermoplasmata	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
MMD1_k127_434603_4	224325.AF_0525	2.604e-76	267.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMD1_k127_434603_15	572478.Vdis_2063	1.776e-07	59.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMD1_k127_434603_3	439481.Aboo_1152	4.284e-81	284.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMD1_k127_434603_14	456442.Mboo_1952	5.745e-12	76.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,2NA0J@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMD1_k127_434603_9	439481.Aboo_1154	1.143e-38	145.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,3F2Q7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	binds to the 23S rRNA	rpl44e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMD1_k127_434603_13	694440.JOMF01000009_gene738	1.067e-18	93.0	arCOG07446@1|root,arCOG07446@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_434603_1	304371.MCP_2734	1.329e-91	312.0	arCOG03776@1|root,arCOG03776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
MMD1_k127_434603_6	304371.MCP_2735	8.859e-74	256.0	arCOG03776@1|root,arCOG03776@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TF_Zn_Ribbon
MMD1_k127_434603_0	351160.RCIX132	1.346e-158	507.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XYA0@28890|Euryarchaeota	28890|Euryarchaeota	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
MMD1_k127_434603_10	694440.JOMF01000009_gene737	1.57e-36	152.0	arCOG05710@1|root,arCOG05710@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_434603_7	673860.AciM339_0069	2.712e-63	232.0	COG0668@1|root,arCOG01568@2157|Archaea,2XUW2@28890|Euryarchaeota,3F2R0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Mechanosensitive ion channel	-	-	-	ko:K03442,ko:K05802,ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.2,1.A.23.4	-	-	MS_channel
MMD1_k127_4350388_1	416348.Hlac_2824	3.244e-45	188.0	COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_4350388_0	1054217.TALC_01532	6.755e-47	190.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
MMD1_k127_4350388_2	263820.PTO0696	3.751e-27	122.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,241PF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	HD,Trm56
MMD1_k127_4352538_4	1173024.KI912149_gene6263	2.695e-92	313.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1GKR9@1117|Cyanobacteria,1JMKR@1189|Stigonemataceae	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_4352538_0	909663.KI867150_gene2168	2.142e-143	461.0	COG0519@1|root,COG0519@2|Bacteria,1NR5X@1224|Proteobacteria,42YTH@68525|delta/epsilon subdivisions,2WUIJ@28221|Deltaproteobacteria,2MR8H@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	GMP synthase C terminal domain	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
MMD1_k127_4352538_6	439235.Dalk_1630	2.308e-28	119.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
MMD1_k127_4352538_1	706587.Desti_0013	4.619e-141	462.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MRFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMD1_k127_4352538_3	1049564.TevJSym_az00280	9.397e-102	359.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD1_k127_4352538_5	706587.Desti_0011	2.775e-51	201.0	COG1014@1|root,COG1014@2|Bacteria,1R8XG@1224|Proteobacteria,42NPD@68525|delta/epsilon subdivisions,2WMQ1@28221|Deltaproteobacteria,2MRSP@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMD1_k127_4352538_2	1121430.JMLG01000004_gene898	3.485e-112	374.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
MMD1_k127_4359725_0	1469613.JT55_13250	3.026e-54	217.0	2F03P@1|root,33T7B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4359725_1	215803.DB30_0610	7.678e-24	119.0	COG2854@1|root,COG2854@2|Bacteria	2|Bacteria	Q	intermembrane phospholipid transfer	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
MMD1_k127_4373088_2	1123226.KB899277_gene1580	1.018e-13	86.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4373088_0	1041930.Mtc_0138	3.228e-126	427.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMD1_k127_4373088_1	304371.MCP_1614	5.806e-16	92.0	COG2203@1|root,arCOG02350@1|root,arCOG06516@1|root,arCOG06712@1|root,arCOG02350@2157|Archaea,arCOG02356@2157|Archaea,arCOG06516@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
MMD1_k127_4382349_6	1041930.Mtc_0311	1.83e-08	68.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota	28890|Euryarchaeota	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMD1_k127_4382349_7	351160.RCIX823	3.184e-08	67.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota	28890|Euryarchaeota	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMD1_k127_4382349_0	28564.XP_002484181.1	3.528e-287	932.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta,3NW85@4751|Fungi,3QMJB@4890|Ascomycota,20C9C@147545|Eurotiomycetes,3S56W@5042|Eurotiales	4751|Fungi	F	Bifunctional pyrimidine biosynthesis protein (PyrABCN)	URA2	GO:0000050,GO:0003674,GO:0003824,GO:0003922,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006142,GO:0006206,GO:0006207,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009892,GO:0009987,GO:0016020,GO:0016021,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019219,GO:0019222,GO:0019627,GO:0019752,GO:0019856,GO:0031224,GO:0031323,GO:0031324,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045934,GO:0045984,GO:0046112,GO:0046394,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0055086,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0080090,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.2,6.3.5.5	ko:K01954,ko:K11541	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R01397,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC02750,RC02798,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N
MMD1_k127_4382349_4	1121101.HMPREF1532_00103	6.125e-66	249.0	COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,2FMKD@200643|Bacteroidia,4AK6X@815|Bacteroidaceae	976|Bacteroidetes	F	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMD1_k127_4382349_3	946362.XP_004998494.1	3.498e-116	385.0	COG0458@1|root,KOG0370@2759|Eukaryota,38CAC@33154|Opisthokonta	33154|Opisthokonta	F	carbamoylphosphate synthase	CPS1	GO:0000050,GO:0000052,GO:0000096,GO:0000166,GO:0001101,GO:0001505,GO:0001889,GO:0002237,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0004175,GO:0005488,GO:0005509,GO:0005524,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006082,GO:0006508,GO:0006520,GO:0006525,GO:0006526,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007275,GO:0007494,GO:0008015,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008289,GO:0008652,GO:0009056,GO:0009058,GO:0009064,GO:0009084,GO:0009295,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009719,GO:0009725,GO:0009888,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010243,GO:0014070,GO:0014074,GO:0014075,GO:0016020,GO:0016042,GO:0016053,GO:0016595,GO:0016597,GO:0016787,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0017144,GO:0019240,GO:0019433,GO:0019538,GO:0019627,GO:0019637,GO:0019752,GO:0019866,GO:0030154,GO:0030554,GO:0030855,GO:0031090,GO:0031406,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032094,GO:0032496,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032870,GO:0032991,GO:0033762,GO:0033993,GO:0034201,GO:0034641,GO:0035150,GO:0035295,GO:0035296,GO:0035639,GO:0036094,GO:0042133,GO:0042221,GO:0042311,GO:0042493,GO:0042592,GO:0042594,GO:0042645,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043200,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043434,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044283,GO:0044344,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0046209,GO:0046394,GO:0046461,GO:0046464,GO:0046486,GO:0046503,GO:0046683,GO:0046872,GO:0048513,GO:0048545,GO:0048565,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050667,GO:0050801,GO:0050880,GO:0050896,GO:0051384,GO:0051591,GO:0051704,GO:0051707,GO:0051716,GO:0055081,GO:0055123,GO:0060416,GO:0060429,GO:0061008,GO:0065007,GO:0065008,GO:0070011,GO:0070013,GO:0070365,GO:0070408,GO:0070409,GO:0070542,GO:0070848,GO:0070887,GO:0071229,GO:0071310,GO:0071320,GO:0071363,GO:0071375,GO:0071377,GO:0071396,GO:0071398,GO:0071400,GO:0071407,GO:0071417,GO:0071495,GO:0071548,GO:0071704,GO:0071774,GO:0071941,GO:0072341,GO:0072593,GO:0090066,GO:0090407,GO:0097159,GO:0097237,GO:0097327,GO:0097367,GO:0097746,GO:0097755,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607,GO:1901652,GO:1901653,GO:1901654,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1903717,GO:1903718,GO:2001057	2.1.3.2,6.3.4.16,6.3.5.5	ko:K01948,ko:K11541	ko00220,ko00240,ko00250,ko00910,ko01100,ko01120,ko01200,ko01230,map00220,map00240,map00250,map00910,map01100,map01120,map01200,map01230	M00029,M00051	R00149,R00256,R00575,R01395,R01397,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC02750,RC02798,RC02804,RC02850,RC03314	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS
MMD1_k127_4382349_8	1121406.JAEX01000002_gene791	5.216e-05	52.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria,42TNE@68525|delta/epsilon subdivisions,2WQI7@28221|Deltaproteobacteria,2MCG3@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_4382349_1	1047013.AQSP01000073_gene1101	1.815e-179	574.0	COG0281@1|root,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria	2|Bacteria	C	Malic enzyme, NAD binding domain	mez_1	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
MMD1_k127_4382349_2	1382359.JIAL01000001_gene2614	2.672e-136	445.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD1_k127_4382349_5	1115803.HMPREF1129_0956	1.682e-11	74.0	COG2095@1|root,COG2095@2|Bacteria,2GMCM@201174|Actinobacteria,4D50V@85005|Actinomycetales	201174|Actinobacteria	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMD1_k127_4385769_1	767817.Desgi_4333	1.212e-88	308.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMD1_k127_4385769_2	439481.Aboo_0790	1.205e-42	166.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,3F2T7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMD1_k127_4385769_0	439481.Aboo_0866	5.343e-121	403.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F32D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD1_k127_4385769_3	472175.EL18_02420	2.816e-09	68.0	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,2TXN3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_3
MMD1_k127_4389232_0	593750.Metfor_0543	0.0004538	53.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota	28890|Euryarchaeota	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
MMD1_k127_4406772_5	351160.LRC320	6.12e-10	63.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,2N95K@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_4406772_1	304371.MCP_1195	1.234e-98	339.0	COG0842@1|root,arCOG01463@2157|Archaea,2XVQJ@28890|Euryarchaeota,2NB7X@224756|Methanomicrobia	224756|Methanomicrobia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD1_k127_4406772_4	591157.SSLG_05628	2.834e-11	76.0	COG1409@1|root,COG4632@1|root,COG1409@2|Bacteria,COG4632@2|Bacteria,2GNTM@201174|Actinobacteria	201174|Actinobacteria	G	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NAGPA
MMD1_k127_4406772_3	243231.GSU2914	2.286e-24	121.0	COG3391@1|root,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria,43C5A@68525|delta/epsilon subdivisions,2WNBK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4406772_2	1297742.A176_05132	1.2e-27	132.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
MMD1_k127_4406772_0	439481.Aboo_0846	4.981e-154	497.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,3F37W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	class II (D K and N)	asnS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMD1_k127_4406772_6	351160.RCIX981	2.516e-09	70.0	COG0642@1|root,arCOG03799@1|root,arCOG06536@1|root,arCOG03799@2157|Archaea,arCOG06192@2157|Archaea,arCOG06536@2157|Archaea,2Y7UB@28890|Euryarchaeota,2NBMX@224756|Methanomicrobia	28890|Euryarchaeota	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_9,Response_reg
MMD1_k127_4408213_0	391623.TERMP_00992	2.828e-170	545.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMD1_k127_4412494_2	638303.Thal_0484	8.84e-10	66.0	COG2018@1|root,COG2018@2|Bacteria,2G4D2@200783|Aquificae	200783|Aquificae	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
MMD1_k127_4412494_3	272134.KB731324_gene2305	1.198e-08	63.0	COG1719@1|root,COG1719@2|Bacteria,1G2GQ@1117|Cyanobacteria,1H7YS@1150|Oscillatoriales	1117|Cyanobacteria	S	hydrocarbon binding protein (contains V4R domain)	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	V4R
MMD1_k127_4412494_1	351160.LRC375	3.032e-20	102.0	arCOG02346@1|root,arCOG03799@1|root,arCOG06940@1|root,arCOG02346@2157|Archaea,arCOG03799@2157|Archaea,arCOG06940@2157|Archaea	2157|Archaea	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Anticodon_1,DUF835,GAF_2,GAF_3,HAMP,HATPase_c,PAS,PAS_3,PAS_9,Response_reg,zinc_ribbon_2
MMD1_k127_4412494_0	383372.Rcas_3603	6.961e-33	134.0	COG1100@1|root,COG1100@2|Bacteria,2G9IC@200795|Chloroflexi,3777W@32061|Chloroflexia	32061|Chloroflexia	S	SMART Ras small GTPase, Ras type	-	-	-	-	-	-	-	-	-	-	-	-	Ras
MMD1_k127_4418055_1	269797.Mbar_A1077	3.528e-34	141.0	COG1237@1|root,arCOG00503@2157|Archaea,2XXGE@28890|Euryarchaeota,2N9XT@224756|Methanomicrobia	224756|Methanomicrobia	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
MMD1_k127_4418055_5	1206731.BAGB01000170_gene4485	9.658e-08	61.0	COG1765@1|root,COG1765@2|Bacteria,2IE9R@201174|Actinobacteria,4G96S@85025|Nocardiaceae	201174|Actinobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
MMD1_k127_4418055_3	264732.Moth_0436	7.539e-19	88.0	COG0425@1|root,COG0425@2|Bacteria,1UF14@1239|Firmicutes,25K1R@186801|Clostridia,42IV0@68295|Thermoanaerobacterales	2|Bacteria	O	Sulfurtransferase TusA	yrkI	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	-	-	-	-	-	-	-	-	-	Rhodanese,TusA
MMD1_k127_4418055_4	192952.MM_2042	1.43e-17	96.0	COG3355@1|root,arCOG02242@2157|Archaea,2XX1H@28890|Euryarchaeota,2NB0S@224756|Methanomicrobia	224756|Methanomicrobia	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMD1_k127_4418055_0	351160.RCIX501	9.172e-88	307.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,2N97N@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	ndh	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMD1_k127_4418055_2	715451.ambt_13580	5.037e-21	109.0	COG2373@1|root,COG2911@1|root,COG3210@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,465B9@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
MMD1_k127_4420324_0	1196028.ALEF01000022_gene2055	3.477e-05	58.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli,4C6IA@84406|Virgibacillus	91061|Bacilli	O	Carboxypeptidase regulatory-like domain	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8
MMD1_k127_4420807_3	269799.Gmet_0586	2.652e-35	149.0	COG0535@1|root,COG0535@2|Bacteria,1RADC@1224|Proteobacteria,42RDA@68525|delta/epsilon subdivisions,2WN4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
MMD1_k127_4420807_2	573064.Mefer_0731	2.202e-44	183.0	COG0503@1|root,arCOG00030@2157|Archaea,2XTWM@28890|Euryarchaeota,23Q0J@183939|Methanococci	183939|Methanococci	F	Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
MMD1_k127_4420807_0	456442.Mboo_0768	1.452e-119	402.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,2N91D@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMD1_k127_4420807_1	224325.AF_1788	4.357e-51	190.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMD1_k127_4423183_2	673860.AciM339_0002	6.293e-35	147.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y6XH@28890|Euryarchaeota,3F2QN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMD1_k127_4423183_0	404380.Gbem_3026	5.803e-61	216.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,43U1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMD1_k127_4423183_3	32057.KB217478_gene5171	6.386e-10	70.0	COG0457@1|root,COG0457@2|Bacteria,1G1U5@1117|Cyanobacteria,1HJ1H@1161|Nostocales	1117|Cyanobacteria	M	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
MMD1_k127_4423183_1	1260251.SPISAL_03065	4.101e-49	186.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1WX98@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMD1_k127_4423183_4	1218173.BALCAV_0208130	0.0002378	55.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli,1ZDEQ@1386|Bacillus	91061|Bacilli	O	COG1404 Subtilisin-like serine proteases	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8
MMD1_k127_4453525_0	76636.JOEC01000002_gene2862	3.901e-18	96.0	COG2931@1|root,COG2931@2|Bacteria,2ICU9@201174|Actinobacteria,4FMQX@85023|Microbacteriaceae	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4465266_0	1094980.Mpsy_3151	2.735e-37	160.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4477436_11	596151.DesfrDRAFT_3884	5.575e-05	51.0	COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,432IF@68525|delta/epsilon subdivisions,2WYD2@28221|Deltaproteobacteria,2MC0N@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM VanZ	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
MMD1_k127_4477436_2	304371.MCP_0436	2.957e-81	283.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
MMD1_k127_4477436_3	1173028.ANKO01000028_gene3247	2.494e-45	191.0	COG0689@1|root,COG0823@1|root,COG2374@1|root,COG2931@1|root,COG3210@1|root,COG0689@2|Bacteria,COG0823@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales	1117|Cyanobacteria	QU	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,FG-GAP,He_PIG,HemolysinCabind,VCBS
MMD1_k127_4477436_6	529709.PYCH_04480	2.829e-33	135.0	COG0432@1|root,arCOG04214@2157|Archaea,2XXSW@28890|Euryarchaeota,2449A@183968|Thermococci	183968|Thermococci	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
MMD1_k127_4477436_5	1200557.JHWV01000007_gene1950	4.91e-41	158.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H408@909932|Negativicutes	909932|Negativicutes	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
MMD1_k127_4477436_7	1220534.B655_0885	1.466e-25	123.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota	28890|Euryarchaeota	C	reductase	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
MMD1_k127_4477436_1	387631.Asulf_01862	7.193e-82	297.0	COG1139@1|root,arCOG00335@2157|Archaea,2Y85J@28890|Euryarchaeota,246XX@183980|Archaeoglobi	28890|Euryarchaeota	C	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	Fer4_8,LUD_dom
MMD1_k127_4477436_0	1041930.Mtc_1540	3.469e-123	418.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2N924@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM PilT protein domain protein	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
MMD1_k127_4477436_8	1121468.AUBR01000024_gene3037	2.22e-23	107.0	COG2945@1|root,COG2945@2|Bacteria	2|Bacteria	-	-	QU41_16170	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S15
MMD1_k127_4477436_9	572478.Vdis_0689	3.462e-18	100.0	COG1143@1|root,COG1148@1|root,arCOG01543@2157|Archaea,arCOG02235@2157|Archaea,arCOG02236@2157|Archaea,2XS2Y@28889|Crenarchaeota	2157|Archaea	C	Pyridine nucleotide-disulphide oxidoreductase	ehbL	-	1.1.98.4,1.12.98.1,1.8.4.10,1.8.4.8,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00390,ko:K00441,ko:K03388,ko:K14121,ko:K16886,ko:K22174,ko:K22480	ko00680,ko00920,ko01100,ko01120,ko01200,map00680,map00920,map01100,map01120,map01200	M00176,M00356,M00357,M00563,M00567	R02021,R03025,R04540,R11928,R11931,R11943,R11944	RC00007,RC00011,RC02628,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,NAD_binding_8,PAPS_reduct,Pyr_redox_2
MMD1_k127_4477436_10	1125863.JAFN01000001_gene1552	1.229e-09	72.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	2|Bacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Fer4_4,Fer4_7,NAD_binding_8,Pyr_redox_2
MMD1_k127_4477436_4	1265505.ATUG01000001_gene3591	1.598e-44	175.0	COG0247@1|root,COG0247@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MIBB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Fer4_9,FlpD
MMD1_k127_4525895_1	1120999.JONM01000012_gene2242	2.2e-26	128.0	COG0823@1|root,COG0841@1|root,COG1361@1|root,COG1572@1|root,COG1657@1|root,COG2373@1|root,COG4733@1|root,COG0823@2|Bacteria,COG0841@2|Bacteria,COG1361@2|Bacteria,COG1572@2|Bacteria,COG1657@2|Bacteria,COG2373@2|Bacteria,COG4733@2|Bacteria,1QV7E@1224|Proteobacteria,2WHIN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD1_k127_4525895_0	1042877.GQS_03935	6.041e-64	234.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,242SE@183968|Thermococci	183968|Thermococci	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMD1_k127_4537609_0	1220534.B655_1054	3.766e-209	694.0	COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota	28890|Euryarchaeota	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
MMD1_k127_4537609_1	153948.NAL212_0227	4.491e-32	134.0	COG0500@1|root,COG2226@2|Bacteria,1PE85@1224|Proteobacteria,2W92M@28216|Betaproteobacteria,373FB@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMD1_k127_454328_1	926569.ANT_07500	2.501e-12	80.0	COG1470@1|root,COG2374@1|root,COG1470@2|Bacteria,COG2374@2|Bacteria,2G82K@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Endonuclease exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_5,Exo_endo_phos,LTD
MMD1_k127_454328_0	374847.Kcr_0727	1.088e-12	81.0	COG3291@1|root,arCOG02508@2157|Archaea	2157|Archaea	G	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Malectin,PKD
MMD1_k127_4551464_0	485914.Hmuk_0622	6.167e-22	113.0	COG3291@1|root,COG3979@1|root,arCOG02546@2157|Archaea,arCOG07581@2157|Archaea,2Y7P8@28890|Euryarchaeota,23S91@183963|Halobacteria	183963|Halobacteria	G	protein contain chitin-binding domain type 3	-	-	-	-	-	-	-	-	-	-	-	-	CBM_5_12,PKD
MMD1_k127_4551464_1	326424.FRAAL3357	1.869e-12	69.0	COG0424@1|root,COG0424@2|Bacteria,2GNI0@201174|Actinobacteria	201174|Actinobacteria	D	Maf-like protein	maf	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf,NUDIX
MMD1_k127_4559906_0	1499968.TCA2_2767	2.702e-05	57.0	COG1361@1|root,COG2931@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1V4V3@1239|Firmicutes,4HT0D@91061|Bacilli	91061|Bacilli	M	TIGRFAM conserved repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_4567781_0	5888.CAK83391	9.818e-47	185.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
MMD1_k127_4567781_1	51453.EGR50084	3.136e-36	145.0	2ECYW@1|root,2SIQI@2759|Eukaryota,3A1GD@33154|Opisthokonta,3P2GI@4751|Fungi,3R153@4890|Ascomycota	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4567781_3	196162.Noca_4679	2.321e-09	69.0	COG3291@1|root,COG4412@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K13735,ko:K20276,ko:K21449	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	CARDB,CHU_C,DUF11,PKD,Peptidase_M30
MMD1_k127_4567781_2	366394.Smed_5191	1.673e-14	82.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,4BCYP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
MMD1_k127_456850_3	351160.RRC525	4.325e-51	201.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMD1_k127_456850_0	1410668.JNKC01000004_gene43	9.987e-89	297.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36ES4@31979|Clostridiaceae	186801|Clostridia	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
MMD1_k127_456850_1	272562.CA_C0244	4.498e-80	281.0	COG4591@1|root,COG4591@2|Bacteria,1TQ8J@1239|Firmicutes,24BJ2@186801|Clostridia,36ETG@31979|Clostridiaceae	186801|Clostridia	M	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
MMD1_k127_456850_2	398512.JQKC01000032_gene4460	5.04e-61	221.0	COG5012@1|root,COG5012@2|Bacteria,1V5EH@1239|Firmicutes,24HIB@186801|Clostridia,3WMC9@541000|Ruminococcaceae	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
MMD1_k127_4570178_7	335659.S23_49100	2.402e-07	60.0	COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,2TX8S@28211|Alphaproteobacteria,3JSYQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD1_k127_4570178_6	644281.MFS40622_1797	2.949e-27	114.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,23R5H@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
MMD1_k127_4570178_3	1054217.TALC_00043	4.9e-76	267.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,241SB@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMD1_k127_4570178_2	439481.Aboo_0862	5.699e-79	269.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,3F2IX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMD1_k127_4570178_4	1236689.MMALV_00450	9.625e-56	198.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,3F2N7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMD1_k127_4570178_5	362976.HQ_1241A	6.915e-40	159.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,23V72@183963|Halobacteria	183963|Halobacteria	K	Transcription elongation factor Spt5	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
MMD1_k127_4570178_8	439481.Aboo_0865	7.035e-05	49.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y6IU@28890|Euryarchaeota,3F2UZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	TIGRFAM protein translocase SEC61 complex gamma subunit	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
MMD1_k127_4570178_0	673860.AciM339_0142	6.441e-142	459.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F32D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD1_k127_4570178_1	673860.AciM339_0142	9.476e-116	381.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F32D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD1_k127_4572221_1	118168.MC7420_4537	0.0003561	48.0	2C97T@1|root,338QQ@2|Bacteria,1GDWE@1117|Cyanobacteria,1HFMM@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
MMD1_k127_4572221_0	1034347.CAHJ01000042_gene4824	1.109e-06	63.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli,1ZDEQ@1386|Bacillus	91061|Bacilli	O	COG1404 Subtilisin-like serine proteases	bpr	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8
MMD1_k127_4572246_0	673860.AciM339_0256	5.256e-125	411.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,3F2GX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMD1_k127_4573383_0	1121468.AUBR01000022_gene2785	6.009e-192	613.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
MMD1_k127_4573710_0	868131.MSWAN_0582	1.944e-108	363.0	COG0842@1|root,arCOG01463@2157|Archaea,2XWB7@28890|Euryarchaeota,23PY9@183925|Methanobacteria	183925|Methanobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD1_k127_4573710_2	868131.MSWAN_0583	3.245e-74	257.0	COG1131@1|root,arCOG00194@2157|Archaea,2XWVA@28890|Euryarchaeota	28890|Euryarchaeota	E	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_4573710_4	1200792.AKYF01000027_gene541	9.286e-16	87.0	COG1309@1|root,COG1309@2|Bacteria,1VIDE@1239|Firmicutes,4HQMD@91061|Bacilli,26ZZY@186822|Paenibacillaceae	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMD1_k127_4573710_3	395495.Lcho_3739	7.852e-34	152.0	COG0689@1|root,COG5276@1|root,COG0689@2|Bacteria,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
MMD1_k127_4573710_5	399742.Ent638_3119	5.108e-14	87.0	COG2373@1|root,COG2373@2|Bacteria,1QV7E@1224|Proteobacteria,1SM3U@1236|Gammaproteobacteria,3X3FS@547|Enterobacter	1236|Gammaproteobacteria	S	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD1_k127_4573710_7	1210908.HSB1_14460	1.291e-06	63.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,241E1@183963|Halobacteria	183963|Halobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4573710_6	240015.ACP_1005	2.262e-11	70.0	COG1722@1|root,COG1722@2|Bacteria,3Y5H0@57723|Acidobacteria,2JK24@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
MMD1_k127_4573710_1	292459.STH1846	1.877e-101	349.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
MMD1_k127_4576939_1	1313421.JHBV01000015_gene5729	1.116e-14	89.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Gram_pos_anchor
MMD1_k127_4576939_0	658086.HMPREF0994_04801	2.182e-21	111.0	COG4409@1|root,COG4409@2|Bacteria,1V5Q1@1239|Firmicutes,24FGZ@186801|Clostridia,27R3R@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolases family 32 N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
MMD1_k127_4576939_2	717231.Flexsi_0377	2.661e-06	61.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32N
MMD1_k127_4577567_0	1382306.JNIM01000001_gene3401	6.128e-62	228.0	COG1600@1|root,COG1600@2|Bacteria,2G6A0@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Dehalogenase,Fer4_16,HEAT_2
MMD1_k127_4577567_2	981383.AEWH01000003_gene1489	0.0001354	53.0	COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,4HB4C@91061|Bacilli	91061|Bacilli	E	YoaP-like	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
MMD1_k127_4577567_1	742767.HMPREF9456_00849	3.246e-07	61.0	COG1246@1|root,COG1246@2|Bacteria,4PMBQ@976|Bacteroidetes,2G116@200643|Bacteroidia,2327Z@171551|Porphyromonadaceae	976|Bacteroidetes	E	YoaP-like	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,YoaP
MMD1_k127_4579350_2	391625.PPSIR1_24714	3.83e-20	99.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,Methyltransf_21,Methyltransf_24
MMD1_k127_4579350_0	868131.MSWAN_2212	5.645e-57	207.0	COG1985@1|root,arCOG01489@2157|Archaea,2Y3MD@28890|Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
MMD1_k127_4579350_1	589924.Ferp_0541	6.191e-42	161.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD1_k127_4594123_2	224325.AF_0462	1.152e-20	105.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,246WJ@183980|Archaeoglobi	183980|Archaeoglobi	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
MMD1_k127_4594123_0	439481.Aboo_0536	4.824e-113	375.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,3F2IT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
MMD1_k127_4594123_1	351160.RCIX1470	2.715e-65	238.0	COG5421@1|root,arCOG03473@2157|Archaea	351160.RCIX1470|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4634173_2	1124982.MSI_06630	0.0003031	54.0	COG3291@1|root,COG3291@2|Bacteria,2J5PG@203691|Spirochaetes	203691|Spirochaetes	M	Protein conserved in bacteria	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
MMD1_k127_4634173_1	1220534.B655_0825	2.007e-50	186.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,23PMF@183925|Methanobacteria	183925|Methanobacteria	C	Fe-S cluster	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMD1_k127_4634173_0	1414720.CBYM010000004_gene163	7.623e-56	199.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMD1_k127_4655581_0	479434.Sthe_2136	7.954e-118	400.0	COG0477@1|root,COG0477@2|Bacteria,2G5X2@200795|Chloroflexi,27ZD8@189775|Thermomicrobia	189775|Thermomicrobia	P	Fungal trichothecene efflux pump (TRI12)	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD1_k127_4655581_1	635013.TherJR_1083	2.267e-60	216.0	arCOG14814@1|root,2ZC63@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4655581_2	521011.Mpal_0671	3.219e-43	169.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD1_k127_4655581_3	1054217.TALC_01530	1.056e-28	119.0	COG1418@1|root,arCOG01858@2157|Archaea	2157|Archaea	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMD1_k127_4657982_0	246200.SPO0571	1.572e-05	58.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_4659902_5	673860.AciM339_0075	3.914e-16	79.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,3F2TZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
MMD1_k127_4659902_0	1054217.TALC_00169	1.01e-82	279.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMD1_k127_4659902_1	673860.AciM339_1253	4.357e-63	226.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,3F2NT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Belongs to the MEMO1 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMD1_k127_4659902_6	1502852.FG94_02059	6.057e-10	72.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,473AI@75682|Oxalobacteraceae	1224|Proteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K02004,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	FtsX,MacB_PCD
MMD1_k127_4659902_2	926690.KE386573_gene154	1.185e-60	222.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,23T7A@183963|Halobacteria	183963|Halobacteria	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_4659902_4	298655.KI912266_gene3839	3.806e-16	91.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EVR3@85013|Frankiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_4659902_3	485918.Cpin_4113	7.446e-28	131.0	COG2911@1|root,COG2911@2|Bacteria,4NHHA@976|Bacteroidetes,1IVM6@117747|Sphingobacteriia	976|Bacteroidetes	M	Domain of unknown function	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG
MMD1_k127_466291_1	1089545.KB913037_gene2608	5.603e-05	57.0	COG2730@1|root,COG2755@1|root,COG5297@1|root,COG2730@2|Bacteria,COG2755@2|Bacteria,COG5297@2|Bacteria,2GKTY@201174|Actinobacteria,4DYMC@85010|Pseudonocardiales	201174|Actinobacteria	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CBM_10,CBM_2,Cellulase,Lipase_GDSL_2,fn3
MMD1_k127_466291_0	264732.Moth_0241	3.248e-24	121.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Calx-beta,DUF11,DUF1573,F5_F8_type_C,FG-GAP,Glyco_hyd_101C,Glyco_hydro_101,NPCBM_assoc,SASA
MMD1_k127_4663194_4	673860.AciM339_0132	1.609e-39	153.0	COG1633@1|root,arCOG01103@2157|Archaea,2Y69T@28890|Euryarchaeota,3F3G4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMD1_k127_4663194_1	926561.KB900617_gene1208	2.401e-79	270.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3WC58@53433|Halanaerobiales	186801|Clostridia	C	Ferritin-like domain	rbr	GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMD1_k127_4663194_6	644281.MFS40622_1437	1.346e-13	79.0	COG1773@1|root,arCOG05047@2157|Archaea,2XZY1@28890|Euryarchaeota,23R7T@183939|Methanococci	183939|Methanococci	C	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4663194_0	760568.Desku_3095	1.216e-186	589.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,2619Q@186807|Peptococcaceae	186801|Clostridia	C	PFAM Flavodoxin	-	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
MMD1_k127_4663194_5	760568.Desku_3094	7.732e-25	105.0	COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,266U0@186807|Peptococcaceae	186801|Clostridia	C	Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
MMD1_k127_4663194_2	290397.Adeh_1286	8.28e-64	226.0	COG0454@1|root,COG0456@2|Bacteria,1RD40@1224|Proteobacteria,43EF3@68525|delta/epsilon subdivisions,2X0ID@28221|Deltaproteobacteria,2Z1N2@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_4663194_3	1324957.K933_00562	1.179e-39	163.0	COG0438@1|root,arCOG01411@2157|Archaea,2Y8BS@28890|Euryarchaeota,2418K@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_4663194_7	1104324.P186_2462	6.663e-12	72.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMD1_k127_4683004_8	1041930.Mtc_2006	1.159e-34	150.0	COG1404@1|root,COG1470@1|root,arCOG00702@2157|Archaea,arCOG02081@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
MMD1_k127_4683004_3	485914.Hmuk_1624	2.661e-92	318.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,23SS9@183963|Halobacteria	183963|Halobacteria	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
MMD1_k127_4683004_10	1054217.TALC_01427	7.909e-26	110.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,241X7@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMD1_k127_4683004_11	593750.Metfor_1113	1.443e-15	85.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,2N9UM@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM RNA polymerase Rpb4	rpoF	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMD1_k127_4683004_4	673860.AciM339_0303	2.825e-66	231.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,3F2KH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Helix-hairpin-helix motif	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMD1_k127_4683004_6	351160.RCIX2352	1.088e-46	179.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,2N9HP@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMD1_k127_4683004_1	439481.Aboo_1029	7.034e-136	443.0	COG1373@1|root,arCOG03167@2157|Archaea,2Y3YG@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMD1_k127_4683004_5	1163407.UU7_11684	1.28e-64	238.0	COG0477@1|root,COG2814@2|Bacteria,1PJVW@1224|Proteobacteria,1RTG0@1236|Gammaproteobacteria,1X80K@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMD1_k127_4683004_13	1169152.AXVD01000015_gene1110	3.334e-10	70.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4FV9W@85025|Nocardiaceae	201174|Actinobacteria	Q	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMD1_k127_4683004_7	883067.HMPREF9237_00266	3.846e-44	185.0	COG1800@1|root,COG2885@1|root,COG3064@1|root,COG1800@2|Bacteria,COG2885@2|Bacteria,COG3064@2|Bacteria,2IC22@201174|Actinobacteria	201174|Actinobacteria	M	Membrane	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	He_PIG,Rib
MMD1_k127_4683004_12	1237500.ANBA01000007_gene2957	1.493e-10	75.0	COG1305@1|root,COG1305@2|Bacteria,2I8PB@201174|Actinobacteria,4ENJ8@85012|Streptosporangiales	201174|Actinobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
MMD1_k127_4683004_0	273075.Ta0068	1.137e-140	460.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2421R@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMD1_k127_4683004_2	997346.HMPREF9374_3242	3.302e-109	370.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,27BE0@186824|Thermoactinomycetaceae	91061|Bacilli	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
MMD1_k127_4715265_0	485914.Hmuk_0622	9.428e-12	79.0	COG3291@1|root,COG3979@1|root,arCOG02546@2157|Archaea,arCOG07581@2157|Archaea,2Y7P8@28890|Euryarchaeota,23S91@183963|Halobacteria	183963|Halobacteria	G	protein contain chitin-binding domain type 3	-	-	-	-	-	-	-	-	-	-	-	-	CBM_5_12,PKD
MMD1_k127_4715265_2	592026.GCWU0000282_001284	0.0003311	54.0	COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,PPC,Peptidase_S8
MMD1_k127_4715265_1	870187.Thini_1774	1.242e-11	79.0	COG2885@1|root,COG2885@2|Bacteria,1R508@1224|Proteobacteria,1RS7G@1236|Gammaproteobacteria,46256@72273|Thiotrichales	72273|Thiotrichales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMD1_k127_4722995_0	673860.AciM339_0643	6.083e-312	970.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F39E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMD1_k127_4727257_1	344747.PM8797T_13008	1.033e-07	64.0	COG0526@1|root,COG3087@1|root,COG0526@2|Bacteria,COG3087@2|Bacteria,2IZ08@203682|Planctomycetes	203682|Planctomycetes	CO	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4727257_0	644966.Tmar_1061	5.285e-39	152.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WCJP@538999|Clostridiales incertae sedis	186801|Clostridia	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
MMD1_k127_4788662_0	673860.AciM339_1488	4.19e-69	240.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,3F2GT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMD1_k127_4788662_1	593117.TGAM_1551	1.978e-55	199.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMD1_k127_4788662_4	679926.Mpet_1063	0.0001408	50.0	arCOG02449@1|root,arCOG02449@2157|Archaea,2XWE6@28890|Euryarchaeota,2N9EQ@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Flavodoxin_3
MMD1_k127_4788662_2	439481.Aboo_0623	1.559e-32	134.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,3F3BY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	TIGRFAM adenylyl cyclase CyaB	cyaB	GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
MMD1_k127_4788662_3	1457250.BBMO01000002_gene2401	1.214e-14	79.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota,23T3H@183963|Halobacteria	183963|Halobacteria	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMD1_k127_4790462_1	1386089.N865_05350	5.505e-34	153.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
MMD1_k127_4790462_0	251221.35214774	2.982e-69	267.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
MMD1_k127_4790462_2	981369.JQMJ01000004_gene1018	6.48e-10	65.0	COG3291@1|root,COG3291@2|Bacteria,2HHTF@201174|Actinobacteria,2NHQJ@228398|Streptacidiphilus	201174|Actinobacteria	S	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Phosphoesterase,fn3
MMD1_k127_4791822_2	574087.Acear_1345	6.469e-63	227.0	COG1397@1|root,COG1397@2|Bacteria,1TQXG@1239|Firmicutes,24C2X@186801|Clostridia,3WBZS@53433|Halanaerobiales	186801|Clostridia	O	ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
MMD1_k127_4791822_1	515635.Dtur_1580	4.853e-117	404.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
MMD1_k127_4791822_3	673860.AciM339_0955	2.33e-31	131.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,3F2NI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
MMD1_k127_4791822_0	673860.AciM339_0956	2.737e-196	642.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,3F2F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMD1_k127_4791822_4	1499967.BAYZ01000104_gene3623	1.505e-18	93.0	COG0590@1|root,COG0590@2|Bacteria	2|Bacteria	FJ	tRNA wobble adenosine to inosine editing	tadA	-	3.5.4.3,3.5.4.33	ko:K01487,ko:K11991	ko00230,ko01100,map00230,map01100	-	R01676,R10223	RC00204,RC00477	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
MMD1_k127_4799194_1	225937.HP15_2784	1.941e-63	225.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,46560@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
MMD1_k127_4799194_5	386456.JQKN01000008_gene1397	3.963e-07	57.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota	28890|Euryarchaeota	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMD1_k127_4799194_6	368408.Tpen_1010	0.0006443	53.0	arCOG03714@1|root,arCOG03714@2157|Archaea,2XQDX@28889|Crenarchaeota	28889|Crenarchaeota	F	ATP cone domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone
MMD1_k127_4799194_4	1220534.B655_0118	6.877e-08	57.0	arCOG03714@1|root,arCOG03714@2157|Archaea	2157|Archaea	F	ATP cone domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
MMD1_k127_4799194_2	456320.Mvol_0794	8.639e-53	201.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_4799194_3	269797.Mbar_A0640	5.08e-17	89.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,2N9VF@224756|Methanomicrobia	224756|Methanomicrobia	C	heterodisulfide reductase subunit C	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD1_k127_4799194_0	1041930.Mtc_0357	2.253e-70	245.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbpE	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMD1_k127_4812235_5	861299.J421_1933	6.351e-34	135.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	cnrT	-	-	-	-	-	-	-	-	-	-	-	EamA
MMD1_k127_4812235_4	871963.Desdi_0586	2.355e-35	137.0	2E4R1@1|root,32ZJK@2|Bacteria,1VEMY@1239|Firmicutes,24NDK@186801|Clostridia,262R6@186807|Peptococcaceae	186801|Clostridia	S	PFAM Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
MMD1_k127_4812235_1	351160.RCIX198	4.135e-74	258.0	COG1208@1|root,arCOG00664@2157|Archaea,2XUHB@28890|Euryarchaeota,2N995@224756|Methanomicrobia	224756|Methanomicrobia	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMD1_k127_4812235_3	246197.MXAN_4612	4.677e-41	170.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2WJC2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
MMD1_k127_4812235_2	868595.Desca_0881	1.798e-56	201.0	COG1898@1|root,COG1898@2|Bacteria,1V4G5@1239|Firmicutes,24IZ8@186801|Clostridia	186801|Clostridia	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
MMD1_k127_4812235_0	1499967.BAYZ01000136_gene53	1.271e-122	402.0	COG1088@1|root,COG1088@2|Bacteria,2NNRC@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3464	GDP_Man_Dehyd
MMD1_k127_4812235_6	1121456.ATVA01000017_gene103	5.396e-16	86.0	COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,42QBP@68525|delta/epsilon subdivisions,2WNRH@28221|Deltaproteobacteria,2MBX5@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM acylneuraminate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_3
MMD1_k127_482007_2	352165.HMPREF7215_0666	1.689e-14	74.0	COG0110@1|root,COG0110@2|Bacteria,3TCJQ@508458|Synergistetes	508458|Synergistetes	S	transferase hexapeptide	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep
MMD1_k127_482007_0	498848.TaqDRAFT_3957	2.731e-24	104.0	COG1669@1|root,COG1669@2|Bacteria,1WKNV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	PFAM DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD1_k127_482007_1	579137.Metvu_0403	9.342e-22	97.0	COG2361@1|root,arCOG05024@2157|Archaea,2XYZR@28890|Euryarchaeota,23RQP@183939|Methanococci	183939|Methanococci	S	to PID 1652090 percent identity	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
MMD1_k127_4835909_0	935866.JAER01000003_gene1309	9.289e-46	187.0	COG1800@1|root,COG2304@1|root,COG1800@2|Bacteria,COG2304@2|Bacteria,2I7AW@201174|Actinobacteria,4DVKU@85009|Propionibacteriales	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4835909_1	215803.DB30_5852	3.174e-18	101.0	COG3325@1|root,COG3391@1|root,COG4412@1|root,COG3325@2|Bacteria,COG3391@2|Bacteria,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2YUKS@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M36,REJ
MMD1_k127_4835909_2	673860.AciM339_1288	2.632e-05	58.0	arCOG02499@1|root,arCOG02499@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
MMD1_k127_4836792_5	573064.Mefer_0808	4.99e-20	89.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,23R2W@183939|Methanococci	183939|Methanococci	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030880,GO:0031323,GO:0031326,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
MMD1_k127_4836792_2	1236689.MMALV_01790	1.488e-71	250.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,3F2MA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
MMD1_k127_4836792_4	1041930.Mtc_2135	7.573e-67	250.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMD1_k127_4836792_3	1094980.Mpsy_1230	1.56e-71	260.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMD1_k127_4836792_0	673860.AciM339_1269	1.636e-258	821.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,3F2F0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase type-B family	polB1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing
MMD1_k127_4836792_1	673860.AciM339_0508	5.199e-150	486.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,3F2GD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	GTPase of unknown function C-terminal	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
MMD1_k127_4842187_10	192952.MM_2534	1.255e-11	69.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
MMD1_k127_4842187_12	8364.ENSXETP00000029410	1.225e-05	60.0	2CMIF@1|root,2QQF0@2759|Eukaryota,38H6E@33154|Opisthokonta,3BIU0@33208|Metazoa,3D19S@33213|Bilateria,48473@7711|Chordata,48YNK@7742|Vertebrata	33208|Metazoa	S	ciliary basal body organization	CROCC	GO:0000226,GO:0001894,GO:0001895,GO:0001917,GO:0003008,GO:0003674,GO:0003779,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007098,GO:0007600,GO:0007605,GO:0007610,GO:0007638,GO:0008092,GO:0008104,GO:0008150,GO:0009605,GO:0009612,GO:0009628,GO:0009987,GO:0010457,GO:0010638,GO:0010669,GO:0010996,GO:0015629,GO:0015630,GO:0016020,GO:0016043,GO:0019894,GO:0022402,GO:0030030,GO:0031023,GO:0031223,GO:0031344,GO:0031346,GO:0032053,GO:0032501,GO:0032879,GO:0032880,GO:0033036,GO:0033043,GO:0033365,GO:0034613,GO:0035253,GO:0042592,GO:0042995,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044087,GO:0044089,GO:0044422,GO:0044424,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044463,GO:0044464,GO:0044782,GO:0045494,GO:0045724,GO:0048518,GO:0048522,GO:0048871,GO:0050789,GO:0050794,GO:0050877,GO:0050896,GO:0050954,GO:0050975,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0051656,GO:0060249,GO:0060341,GO:0060491,GO:0065007,GO:0065008,GO:0070727,GO:0071840,GO:0071944,GO:0097458,GO:0120025,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:1902017,GO:1902115,GO:1902117,GO:1903564,GO:1903566,GO:1903827,GO:1903829	-	ko:K16469	-	-	-	-	ko00000,ko03036	-	-	-	Rootletin
MMD1_k127_4842187_13	906968.Trebr_1520	0.0001118	55.0	2FFB7@1|root,3478X@2|Bacteria,2J8CB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4842187_2	1128421.JAGA01000002_gene1833	9.752e-78	276.0	COG0689@1|root,COG0689@2|Bacteria,2NP3K@2323|unclassified Bacteria	2|Bacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
MMD1_k127_4842187_11	391612.CY0110_15537	4.317e-08	66.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1G1I0@1117|Cyanobacteria,3KK8R@43988|Cyanothece	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,Lectin_C
MMD1_k127_4842187_5	926560.KE387025_gene4045	1.862e-36	157.0	COG1520@1|root,COG1520@2|Bacteria,1WMGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
MMD1_k127_4842187_6	1094980.Mpsy_1769	3.811e-34	139.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2N9RC@224756|Methanomicrobia	224756|Methanomicrobia	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0975	AAA_17,RNA_binding
MMD1_k127_4842187_8	589924.Ferp_0541	2.217e-30	128.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD1_k127_4842187_14	1348663.KCH_68730	0.000631	52.0	2BB2B@1|root,324IF@2|Bacteria,2H9ES@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4842187_15	1448860.BBJO01000003_gene2647	0.0007364	48.0	arCOG02981@1|root,arCOG02981@2157|Archaea,2XY0Y@28890|Euryarchaeota,23W73@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4842187_9	880073.Calab_3690	2.859e-15	78.0	COG3360@1|root,COG3360@2|Bacteria	2|Bacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
MMD1_k127_4842187_4	192952.MM_2297	1.796e-45	184.0	arCOG01814@1|root,arCOG01814@2157|Archaea,2XT74@28890|Euryarchaeota,2N90N@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4842187_0	192952.MM_2298	2.883e-120	417.0	COG4962@1|root,arCOG01818@2157|Archaea,2XTN5@28890|Euryarchaeota,2N9AG@224756|Methanomicrobia	224756|Methanomicrobia	N	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
MMD1_k127_4842187_7	743718.Isova_2180	2.054e-32	133.0	COG4405@1|root,COG4405@2|Bacteria,2IKQP@201174|Actinobacteria,4F4M3@85017|Promicromonosporaceae	201174|Actinobacteria	S	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
MMD1_k127_4842187_1	523850.TON_1888	3.579e-96	334.0	COG1373@1|root,arCOG03167@2157|Archaea,2XW1E@28890|Euryarchaeota,243BI@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMD1_k127_4842187_3	1286171.EAL2_808p04300	3.956e-70	254.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRU@186801|Clostridia	186801|Clostridia	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD1_k127_4846995_1	945713.IALB_2155	4.599e-143	469.0	COG2195@1|root,COG2195@2|Bacteria	2|Bacteria	E	Cleaves the N-terminal amino acid of tripeptides	pepD	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	iPC815.YPO3230,iSBO_1134.SBO_0243	M20_dimer,Peptidase_M20
MMD1_k127_4846995_0	886293.Sinac_5836	5.488e-162	541.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
MMD1_k127_4846995_2	1250232.JQNJ01000001_gene3055	0.0001105	50.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria,4NHHD@976|Bacteroidetes,1HWPE@117743|Flavobacteriia	976|Bacteroidetes	M	Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Kelch_1,Kelch_6,Malectin,PKD
MMD1_k127_4860827_2	673860.AciM339_0628	4.909e-23	104.0	arCOG05238@1|root,arCOG05238@2157|Archaea,2Y0YG@28890|Euryarchaeota,3F3EA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4860827_0	673860.AciM339_1443	3.097e-115	389.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
MMD1_k127_4860827_1	926550.CLDAP_28350	2.856e-47	185.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,G5,Gln_amidase,Gram_pos_anchor,YSIRK_signal,YadA_stalk
MMD1_k127_4869371_3	439481.Aboo_1380	2.382e-09	70.0	arCOG03853@1|root,arCOG03853@2157|Archaea,2Y52X@28890|Euryarchaeota,3F32T@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4869371_2	633148.Tagg_0783	1.108e-37	151.0	COG0095@1|root,arCOG01939@2157|Archaea,2XQ6U@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMD1_k127_4869371_1	224719.Abm4_0181	8.104e-93	318.0	COG0119@1|root,arCOG02092@2157|Archaea,2XV8D@28890|Euryarchaeota,23PFQ@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	aksA	-	2.3.3.14	ko:K10977	ko00300,ko00620,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00620,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R00271,R08213,R08331,R08332	RC00004,RC00067,RC02149,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
MMD1_k127_4869371_0	1054217.TALC_01406	4.608e-117	386.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,241JM@183967|Thermoplasmata	183967|Thermoplasmata	G	4-hydroxy-tetrahydrodipicolinate reductase	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
MMD1_k127_4869371_4	304371.MCP_1705	5.825e-09	68.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,2N9PQ@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM peptidylprolyl isomerase FKBP-type	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMD1_k127_4886371_0	211586.SO_0189	9.119e-59	222.0	COG3637@1|root,COG3637@2|Bacteria,1QVUE@1224|Proteobacteria,1T2J5@1236|Gammaproteobacteria,2QETC@267890|Shewanellaceae	1236|Gammaproteobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,fn3
MMD1_k127_4886371_3	386456.JQKN01000017_gene856	2.064e-08	57.0	COG4870@1|root,arCOG03614@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
MMD1_k127_4886371_2	1125863.JAFN01000001_gene1708	1.788e-08	62.0	COG1917@1|root,COG1917@2|Bacteria,1MZD8@1224|Proteobacteria,42W0P@68525|delta/epsilon subdivisions,2WRDR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD1_k127_4886371_1	671143.DAMO_0892	1.186e-22	97.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.38	ko:K01371	ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_C1
MMD1_k127_48890_0	1500257.JQNM01000001_gene3581	2.413e-29	138.0	COG2931@1|root,COG3210@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4B9MG@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HemolysinCabind,Peptidase_M10_C
MMD1_k127_48890_3	1123296.JQKE01000004_gene821	3.978e-10	75.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,2KS5C@206351|Neisseriales	206351|Neisseriales	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_66,He_PIG,HemolysinCabind
MMD1_k127_48890_1	592316.Pat9b_3211	4.241e-25	124.0	COG3210@1|root,COG4932@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria,1QUXB@1224|Proteobacteria,1T24R@1236|Gammaproteobacteria,3W2YP@53335|Pantoea	1236|Gammaproteobacteria	MU	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
MMD1_k127_48890_4	436308.Nmar_1281	2.26e-05	59.0	COG3398@1|root,arCOG02611@2157|Archaea	2157|Archaea	K	protein conserved in archaea	gntR	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	HTH_20,HTH_24,HTH_5,MarR_2
MMD1_k127_48890_2	1123508.JH636453_gene5800	8.853e-16	91.0	COG3391@1|root,COG3391@2|Bacteria,2J08H@203682|Planctomycetes	203682|Planctomycetes	J	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_4891373_4	1094980.Mpsy_2607	3.479e-38	156.0	COG1305@1|root,arCOG03600@2157|Archaea,2Y7F7@28890|Euryarchaeota,2NA6Q@224756|Methanomicrobia	224756|Methanomicrobia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
MMD1_k127_4891373_0	673860.AciM339_0904	2.129e-110	367.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,3F37Q@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMD1_k127_4891373_2	410359.Pcal_1107	2.369e-42	164.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMD1_k127_4891373_3	593117.TGAM_0970	3.357e-38	162.0	COG0419@1|root,COG2247@1|root,COG2319@1|root,COG5306@1|root,arCOG02559@1|root,arCOG03264@1|root,arCOG00368@2157|Archaea,arCOG00388@2157|Archaea,arCOG02491@2157|Archaea,arCOG02559@2157|Archaea,arCOG03264@2157|Archaea,arCOG03512@2157|Archaea,2XYKK@28890|Euryarchaeota,24394@183968|Thermococci	183968|Thermococci	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,PEGA
MMD1_k127_4891373_5	1125863.JAFN01000001_gene82	3.044e-36	151.0	COG0500@1|root,COG0644@1|root,COG0644@2|Bacteria,COG2226@2|Bacteria,1MXQY@1224|Proteobacteria,42UR3@68525|delta/epsilon subdivisions,2WQQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
MMD1_k127_4891373_1	2002.JOEQ01000021_gene6848	1.819e-82	285.0	COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4EIH3@85012|Streptosporangiales	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	AAA_21,ABC_tran,DUF4162
MMD1_k127_4891373_7	1227454.C446_11927	1.846e-17	96.0	COG1277@1|root,arCOG08617@1|root,arCOG02438@2157|Archaea,arCOG08617@2157|Archaea,2XW39@28890|Euryarchaeota,23SYN@183963|Halobacteria	183963|Halobacteria	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMD1_k127_4891373_6	643648.Slip_1398	7.091e-26	116.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
MMD1_k127_4898623_2	926569.ANT_07500	5.315e-05	56.0	COG1470@1|root,COG2374@1|root,COG1470@2|Bacteria,COG2374@2|Bacteria,2G82K@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Endonuclease exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_5,Exo_endo_phos,LTD
MMD1_k127_4898623_1	387631.Asulf_01782	2.013e-14	76.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMD1_k127_4898623_0	644282.Deba_2986	1.081e-62	226.0	COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria	1224|Proteobacteria	H	PFAM biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
MMD1_k127_4902117_1	1382306.JNIM01000001_gene2472	8.297e-33	135.0	COG1418@1|root,COG1418@2|Bacteria,2G77Y@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMD1_k127_4902117_0	673860.AciM339_0609	1.621e-34	151.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota,3F33E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMD1_k127_4923116_1	983545.Glaag_1619	6.596e-14	87.0	COG2373@1|root,COG2373@2|Bacteria,1QV7E@1224|Proteobacteria,1SM3U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	TIGRFAM Outer membrane protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD1_k127_4923116_0	1397278.AYMV01000014_gene1906	7.714e-15	89.0	COG2931@1|root,COG2931@2|Bacteria,2ICU9@201174|Actinobacteria,4FMQX@85023|Microbacteriaceae	201174|Actinobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4971748_5	56110.Oscil6304_0577	9.436e-23	110.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria,1G2F0@1117|Cyanobacteria,1HF0C@1150|Oscillatoriales	1117|Cyanobacteria	O	Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_4971748_2	292459.STH3243	2.424e-104	353.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
MMD1_k127_4971748_0	439481.Aboo_0129	2.94e-141	462.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,3F31B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.114,4.2.1.33,4.2.1.35	ko:K01703,ko:K16792	ko00290,ko00300,ko00660,ko00680,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00680,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00432,M00433,M00535,M00608	R03444,R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R09720,R10170,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
MMD1_k127_4971748_3	123214.PERMA_0505	6.863e-52	190.0	COG0066@1|root,COG0066@2|Bacteria,2G405@200783|Aquificae	200783|Aquificae	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMD1_k127_4971748_1	1047013.AQSP01000140_gene2452	5.193e-134	436.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
MMD1_k127_4971748_4	926569.ANT_09540	1.497e-32	143.0	COG1361@1|root,COG1721@1|root,COG1361@2|Bacteria,COG1721@2|Bacteria,2G7JJ@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMD1_k127_4994739_0	523845.AQXV01000026_gene1469	2.193e-76	290.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
MMD1_k127_4994739_1	673860.AciM339_0272	3.885e-14	80.0	arCOG03379@1|root,arCOG03379@2157|Archaea,2XZH1@28890|Euryarchaeota,3F2PN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4999408_1	1042877.GQS_03255	3.649e-40	160.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,242SP@183968|Thermococci	183968|Thermococci	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMD1_k127_4999408_2	439481.Aboo_0090	1.424e-19	94.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75P@28890|Euryarchaeota,3F3FQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMD1_k127_4999408_0	768706.Desor_0087	1.553e-87	298.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,2608D@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
MMD1_k127_4999408_5	439481.Aboo_0321	5.002e-06	50.0	arCOG13506@1|root,arCOG13506@2157|Archaea,2Y76D@28890|Euryarchaeota,3F3GT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_4999408_3	304371.MCP_2072	6.192e-14	84.0	COG1082@1|root,arCOG01895@2157|Archaea	2157|Archaea	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,NeuB,SAF
MMD1_k127_4999408_4	1463820.JOGW01000008_gene1473	3.708e-06	59.0	COG0382@1|root,COG0382@2|Bacteria,2GK6R@201174|Actinobacteria	201174|Actinobacteria	H	Pfam UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMD1_k127_5001851_6	608534.GCWU000341_01490	6.24e-09	64.0	2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,2PSW0@265975|Oribacterium	186801|Clostridia	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
MMD1_k127_5001851_0	351160.RCIX79	1.051e-134	446.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMD1_k127_5001851_2	1124780.ANNU01000036_gene56	3.554e-77	269.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_25
MMD1_k127_5001851_1	1267535.KB906767_gene1705	1.199e-77	284.0	COG1032@1|root,COG1032@2|Bacteria,3Y3N8@57723|Acidobacteria,2JMAC@204432|Acidobacteriia	204432|Acidobacteriia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMD1_k127_5001851_5	666685.R2APBS1_0667	6.784e-27	128.0	COG0500@1|root,COG2226@2|Bacteria,1R8N9@1224|Proteobacteria,1SYVC@1236|Gammaproteobacteria,1X2Z5@135614|Xanthomonadales	135614|Xanthomonadales	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMD1_k127_5001851_4	404589.Anae109_1425	1.27e-35	153.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WP3W@28221|Deltaproteobacteria,2Z144@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD1_k127_5032607_23	215803.DB30_7610	3.432e-13	83.0	COG0823@1|root,COG4932@1|root,COG0823@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,43C2M@68525|delta/epsilon subdivisions,2X7D7@28221|Deltaproteobacteria,2Z3FP@29|Myxococcales	28221|Deltaproteobacteria	MU	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_5032607_10	1054217.TALC_00183	2.281e-40	157.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,241TD@183967|Thermoplasmata	183967|Thermoplasmata	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N
MMD1_k127_5032607_25	410359.Pcal_1352	1.445e-07	61.0	COG3465@1|root,arCOG03889@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5032607_0	439481.Aboo_1100	1.377e-133	439.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,3F2H0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
MMD1_k127_5032607_2	237368.SCABRO_03733	3.553e-77	269.0	COG0428@1|root,COG0428@2|Bacteria,2J10N@203682|Planctomycetes	203682|Planctomycetes	P	transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
MMD1_k127_5032607_8	1054217.TALC_00226	1.173e-43	166.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,241R4@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMD1_k127_5032607_9	1094980.Mpsy_1082	5.941e-42	162.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,2N9PZ@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMD1_k127_5032607_12	1121468.AUBR01000030_gene1253	2.209e-37	149.0	COG0518@1|root,COG0518@2|Bacteria,1UAH0@1239|Firmicutes,24DR4@186801|Clostridia,42EZ6@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
MMD1_k127_5032607_21	1236689.MMALV_00200	8.092e-16	91.0	arCOG07412@1|root,arCOG07412@2157|Archaea,2Y0S5@28890|Euryarchaeota,3F2T8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5032607_7	1054217.TALC_00020	1.06e-56	210.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,241RI@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMD1_k127_5032607_4	1236689.MMALV_00300	8.357e-72	258.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,3F2U2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	tRNA intron endonuclease, catalytic C-terminal domain	endA	GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
MMD1_k127_5032607_5	644282.Deba_0763	2.299e-70	251.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMD1_k127_5032607_16	215803.DB30_0631	1.606e-31	136.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria,437IW@68525|delta/epsilon subdivisions,2X2SP@28221|Deltaproteobacteria,2YUPD@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMD1_k127_5032607_1	456442.Mboo_0011	2.732e-80	279.0	COG0580@1|root,arCOG04431@2157|Archaea,2XT1N@28890|Euryarchaeota,2N9IJ@224756|Methanomicrobia	224756|Methanomicrobia	G	TIGRFAM MIP family channel	aqpM	-	-	ko:K02440,ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.2	-	-	MIP
MMD1_k127_5032607_11	698757.Pogu_0448	6.434e-40	160.0	COG0648@1|root,arCOG01894@2157|Archaea,2XPUX@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMD1_k127_5032607_3	1121468.AUBR01000012_gene2574	5.063e-75	265.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales	186801|Clostridia	G	TIGRFAM bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
MMD1_k127_5032607_22	192952.MM_2550	9.27e-15	76.0	arCOG05071@1|root,arCOG05071@2157|Archaea,2Y0VX@28890|Euryarchaeota,2NBB9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2683)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2683
MMD1_k127_5032607_19	192952.MM_2549	5.083e-21	98.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y78I@28890|Euryarchaeota,2NB31@224756|Methanomicrobia	224756|Methanomicrobia	K	addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5032607_27	1463858.JOHR01000006_gene554	0.0009976	52.0	COG1572@1|root,COG1572@2|Bacteria,2H1Z9@201174|Actinobacteria	201174|Actinobacteria	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C
MMD1_k127_5032607_26	502025.Hoch_3634	1.684e-06	63.0	COG4733@1|root,COG5184@1|root,COG4733@2|Bacteria,COG5184@2|Bacteria,1P6WH@1224|Proteobacteria	1224|Proteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5032607_24	4577.GRMZM2G422750_P02	1.152e-07	64.0	28UWV@1|root,2R1MX@2759|Eukaryota,383BV@33090|Viridiplantae,3GZ7N@35493|Streptophyta,3MBKR@4447|Liliopsida,3IPG4@38820|Poales	35493|Streptophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5032607_18	471854.Dfer_3148	2.691e-24	121.0	COG2931@1|root,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
MMD1_k127_5032607_20	6669.EFX77709	6.157e-20	104.0	KOG2649@1|root,KOG2649@2759|Eukaryota,38R1Y@33154|Opisthokonta,3BD7D@33208|Metazoa,3CSIH@33213|Bilateria,41WVG@6656|Arthropoda	33208|Metazoa	S	metallocarboxypeptidase activity. It is involved in the biological process described with proteolysis	CPM	GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0004185,GO:0005575,GO:0005576,GO:0005615,GO:0005623,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0009653,GO:0009986,GO:0009987,GO:0010467,GO:0016020,GO:0016485,GO:0016787,GO:0017171,GO:0019538,GO:0032502,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044421,GO:0044464,GO:0048856,GO:0051604,GO:0070008,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.17.12	ko:K01296	-	-	-	-	ko00000,ko00537,ko01000,ko01002	-	-	-	CarboxypepD_reg,Peptidase_M14
MMD1_k127_5032607_17	537013.CLOSTMETH_03140	6.073e-27	119.0	COG0546@1|root,COG0546@2|Bacteria,1VCQH@1239|Firmicutes,24PMC@186801|Clostridia,3WRJF@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMD1_k127_5032607_13	869210.Marky_0502	3.287e-37	151.0	COG1189@1|root,COG1189@2|Bacteria,1WJ23@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	TIGRFAM hemolysin TlyA family protein	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
MMD1_k127_5032607_6	273075.Ta0577	1.9e-69	252.0	COG0665@1|root,arCOG00755@2157|Archaea,2Y66F@28890|Euryarchaeota,24239@183967|Thermoplasmata	183967|Thermoplasmata	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
MMD1_k127_5032607_14	1151117.AJLF01000002_gene545	4.892e-34	138.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,242MJ@183968|Thermococci	183968|Thermococci	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
MMD1_k127_5032607_15	673860.AciM339_1239	6.416e-32	136.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,3F2T0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Peptidyl-tRNA hydrolase PTH2	pth	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMD1_k127_5034407_3	1499967.BAYZ01000152_gene1389	3.418e-13	83.0	COG0457@1|root,COG0653@1|root,COG3344@1|root,COG0457@2|Bacteria,COG0653@2|Bacteria,COG3344@2|Bacteria	2|Bacteria	L	reverse transcriptase	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
MMD1_k127_5034407_2	264732.Moth_0446	3.924e-72	259.0	COG1856@1|root,COG1856@2|Bacteria,1V23U@1239|Firmicutes,24E3M@186801|Clostridia,42GSP@68295|Thermoanaerobacterales	186801|Clostridia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
MMD1_k127_5034407_0	374847.Kcr_0542	1.611e-121	400.0	COG1131@1|root,arCOG00194@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD1_k127_5034407_1	374847.Kcr_0543	7.675e-103	345.0	COG0842@1|root,arCOG01467@2157|Archaea	2157|Archaea	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMD1_k127_5060628_1	1128421.JAGA01000003_gene2766	6.507e-44	172.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
MMD1_k127_5060628_0	1128421.JAGA01000003_gene2766	5.184e-54	216.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PPC,Peptidase_S8
MMD1_k127_5070574_5	448385.sce2686	8.66e-31	143.0	COG2319@1|root,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YU5N@29|Myxococcales	28221|Deltaproteobacteria	T	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,WD40
MMD1_k127_5070574_4	1123508.JH636439_gene345	7.644e-31	143.0	COG3210@1|root,COG3391@1|root,COG3210@2|Bacteria,COG3391@2|Bacteria,2J08H@203682|Planctomycetes	203682|Planctomycetes	J	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_5070574_1	1386089.N865_05350	3.458e-61	244.0	COG4733@1|root,COG4733@2|Bacteria,2I7XV@201174|Actinobacteria,4FK2V@85021|Intrasporangiaceae	201174|Actinobacteria	M	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
MMD1_k127_5070574_0	251221.35214774	4.405e-89	334.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
MMD1_k127_5070574_2	1246995.AFR_22960	4.37e-58	233.0	COG4733@1|root,COG4733@2|Bacteria,2H7QD@201174|Actinobacteria,4DJZF@85008|Micromonosporales	201174|Actinobacteria	NU	Fibronectin type III domain	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	fn3
MMD1_k127_5070574_3	926690.KE386573_gene183	1.571e-32	138.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,23T3G@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulator	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
MMD1_k127_5070574_6	269797.Mbar_A1800	1.076e-15	91.0	COG1520@1|root,COG3291@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02510@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKW@224756|Methanomicrobia	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CBM_6,DUF3344,NosD,PKD,PQQ_2,PQQ_3,Pkinase
MMD1_k127_5070574_7	266117.Rxyl_0226	1.786e-15	86.0	COG0619@1|root,COG0619@2|Bacteria,2GUVM@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
MMD1_k127_507086_0	1123252.ATZF01000027_gene1612	2.419e-88	332.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_507086_1	1246995.AFR_22960	6.908e-71	275.0	COG4733@1|root,COG4733@2|Bacteria,2H7QD@201174|Actinobacteria,4DJZF@85008|Micromonosporales	201174|Actinobacteria	NU	Fibronectin type III domain	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	fn3
MMD1_k127_5073803_1	1189612.A33Q_1726	1.394e-53	203.0	COG1373@1|root,COG1373@2|Bacteria,4NKY0@976|Bacteroidetes	1189612.A33Q_1726|-	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5073803_4	1001240.GY21_19055	1.459e-05	53.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,2GISC@201174|Actinobacteria,4FKDC@85023|Microbacteriaceae	201174|Actinobacteria	L	SNF2 family N-terminal domain	helZ	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
MMD1_k127_5073803_3	368407.Memar_1872	1.81e-11	67.0	COG3350@1|root,arCOG04507@2157|Archaea,2Y1MF@28890|Euryarchaeota	28890|Euryarchaeota	S	pfam yhs	-	-	-	-	-	-	-	-	-	-	-	-	YHS
MMD1_k127_5073803_2	452637.Oter_3066	6.625e-22	110.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DctA-YdbH
MMD1_k127_5073803_0	523850.TON_1888	6.907e-101	342.0	COG1373@1|root,arCOG03167@2157|Archaea,2XW1E@28890|Euryarchaeota,243BI@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMD1_k127_5083145_1	991905.SL003B_3564	3.624e-27	128.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria,4BRG6@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_5083145_0	56110.Oscil6304_2787	1.764e-73	268.0	COG0501@1|root,COG0501@2|Bacteria,1G16J@1117|Cyanobacteria,1H9Q8@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
MMD1_k127_5113291_1	7739.XP_002611445.1	1.776e-08	68.0	COG1020@1|root,COG1520@1|root,KOG0500@1|root,KOG0500@2759|Eukaryota,KOG1178@2759|Eukaryota,KOG4649@2759|Eukaryota,38CC1@33154|Opisthokonta,3BAEP@33208|Metazoa,3CUYQ@33213|Bilateria,47YYQ@7711|Chordata	33208|Metazoa	P	cyclic nucleotide gated channel alpha	CNGA2	GO:0000003,GO:0000139,GO:0000166,GO:0000902,GO:0001558,GO:0001654,GO:0001666,GO:0001750,GO:0001754,GO:0003008,GO:0003031,GO:0003407,GO:0003674,GO:0005215,GO:0005216,GO:0005217,GO:0005221,GO:0005222,GO:0005223,GO:0005244,GO:0005249,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005798,GO:0005886,GO:0005887,GO:0005929,GO:0006355,GO:0006357,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006873,GO:0006874,GO:0006875,GO:0006935,GO:0006950,GO:0007154,GO:0007165,GO:0007186,GO:0007187,GO:0007199,GO:0007275,GO:0007276,GO:0007283,GO:0007399,GO:0007423,GO:0007600,GO:0007601,GO:0007602,GO:0007603,GO:0007606,GO:0007608,GO:0007610,GO:0007635,GO:0008022,GO:0008150,GO:0008277,GO:0008324,GO:0008361,GO:0009266,GO:0009314,GO:0009416,GO:0009453,GO:0009454,GO:0009581,GO:0009582,GO:0009583,GO:0009584,GO:0009593,GO:0009605,GO:0009628,GO:0009653,GO:0009887,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010752,GO:0010754,GO:0010769,GO:0010975,GO:0012505,GO:0014070,GO:0014074,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015276,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0016056,GO:0017071,GO:0017076,GO:0019001,GO:0019219,GO:0019222,GO:0019722,GO:0019725,GO:0019932,GO:0019934,GO:0019935,GO:0019953,GO:0022008,GO:0022400,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022803,GO:0022832,GO:0022834,GO:0022836,GO:0022838,GO:0022839,GO:0022843,GO:0022857,GO:0022890,GO:0023051,GO:0023052,GO:0023057,GO:0030001,GO:0030003,GO:0030030,GO:0030154,GO:0030182,GO:0030424,GO:0030425,GO:0030516,GO:0030551,GO:0030553,GO:0030660,GO:0031090,GO:0031175,GO:0031224,GO:0031226,GO:0031253,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031344,GO:0031410,GO:0031982,GO:0031984,GO:0032026,GO:0032101,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032553,GO:0032555,GO:0032561,GO:0032989,GO:0032990,GO:0032991,GO:0033267,GO:0034220,GO:0034702,GO:0034703,GO:0035556,GO:0036094,GO:0036293,GO:0036296,GO:0036477,GO:0040008,GO:0040009,GO:0040010,GO:0040011,GO:0040040,GO:0042048,GO:0042221,GO:0042330,GO:0042391,GO:0042461,GO:0042462,GO:0042592,GO:0042622,GO:0042670,GO:0042995,GO:0043005,GO:0043010,GO:0043025,GO:0043052,GO:0043167,GO:0043168,GO:0043195,GO:0043204,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043679,GO:0043855,GO:0043933,GO:0044085,GO:0044297,GO:0044306,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044433,GO:0044441,GO:0044444,GO:0044446,GO:0044456,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0045202,GO:0045595,GO:0045664,GO:0045893,GO:0045927,GO:0045935,GO:0045944,GO:0046530,GO:0046549,GO:0046683,GO:0046873,GO:0048232,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048592,GO:0048593,GO:0048609,GO:0048638,GO:0048666,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048878,GO:0050767,GO:0050770,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050877,GO:0050896,GO:0050906,GO:0050907,GO:0050953,GO:0051128,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051239,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051290,GO:0051291,GO:0051480,GO:0051591,GO:0051606,GO:0051704,GO:0051716,GO:0051899,GO:0051960,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0055093,GO:0060041,GO:0060042,GO:0060170,GO:0060219,GO:0060255,GO:0060284,GO:0061387,GO:0065003,GO:0065007,GO:0065008,GO:0070482,GO:0071214,GO:0071478,GO:0071482,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0072503,GO:0072507,GO:0080090,GO:0090066,GO:0090596,GO:0097159,GO:0097367,GO:0097447,GO:0097458,GO:0097543,GO:0097708,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0098791,GO:0098793,GO:0098796,GO:0098805,GO:0099094,GO:0104004,GO:0120025,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0150034,GO:1901265,GO:1901363,GO:1901698,GO:1901700,GO:1902495,GO:1902531,GO:1902532,GO:1902680,GO:1903506,GO:1903508,GO:1990351,GO:2000026,GO:2000112,GO:2001141	-	ko:K04948,ko:K04949,ko:K04950,ko:K04951	ko04022,ko04024,ko04740,ko04744,map04022,map04024,map04740,map04744	M00694	-	-	ko00000,ko00001,ko00002,ko04040	1.A.1.5.1,1.A.1.5.12,1.A.1.5.13,1.A.1.5.18,1.A.1.5.20,1.A.1.5.3,1.A.1.5.4	-	-	CLZ,Ion_trans,cNMP_binding
MMD1_k127_5113291_0	439481.Aboo_1543	9.502e-117	390.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
MMD1_k127_5113291_2	1223521.BBJX01000019_gene613	4.862e-05	52.0	COG0716@1|root,COG0716@2|Bacteria,1NANK@1224|Proteobacteria,2VW78@28216|Betaproteobacteria,4AHHR@80864|Comamonadaceae	28216|Betaproteobacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
MMD1_k127_5117030_2	351160.RCIX1782	1.306e-56	210.0	COG1620@1|root,arCOG04386@2157|Archaea	2157|Archaea	C	L-lactate permease	lctP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
MMD1_k127_5117030_0	2325.TKV_c19240	2.143e-202	646.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,42EZ8@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_10,POR_N,TPP_enzyme_C
MMD1_k127_5117030_3	398767.Glov_1857	3.107e-47	194.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,43TA9@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
MMD1_k127_5117030_1	944481.JAFP01000001_gene1601	3.662e-150	489.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2M691@213113|Desulfurellales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
MMD1_k127_5117030_5	69042.WH5701_14836	5.689e-19	100.0	COG0477@1|root,COG2814@2|Bacteria,1G0DP@1117|Cyanobacteria,1GYJK@1129|Synechococcus	1117|Cyanobacteria	EGP	Multidrug efflux transporter, MFS family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD1_k127_5117030_4	1123073.KB899241_gene2268	2.915e-41	162.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5133899_3	1302286.BAOT01000012_gene784	0.0006607	51.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1V2NW@1239|Firmicutes,4HGAA@91061|Bacilli,3F6DW@33958|Lactobacillaceae	91061|Bacilli	K	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
MMD1_k127_5133899_1	1033806.HTIA_p3067	3.776e-21	101.0	arCOG04041@1|root,arCOG07592@2157|Archaea,2Y8F4@28890|Euryarchaeota,241A5@183963|Halobacteria	183963|Halobacteria	S	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5133899_0	386456.JQKN01000002_gene2767	9.398e-49	184.0	COG1268@1|root,arCOG02986@2157|Archaea,2XWSG@28890|Euryarchaeota,23P3Q@183925|Methanobacteria	183925|Methanobacteria	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
MMD1_k127_5133899_2	1434325.AZQN01000003_gene2606	2.123e-05	55.0	2EIV4@1|root,33CKF@2|Bacteria,4P7MC@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5139345_0	1500894.JQNN01000001_gene326	7.076e-11	76.0	COG3292@1|root,COG4191@1|root,COG3292@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2WGMB@28216|Betaproteobacteria,4791Q@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Y_Y_Y domain	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
MMD1_k127_5158566_1	595460.RRSWK_04055	9.183e-29	134.0	COG0577@1|root,COG0577@2|Bacteria,2IYHP@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
MMD1_k127_5158566_0	861299.J421_3913	5.311e-41	162.0	COG1912@1|root,COG1912@2|Bacteria,1ZTIH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
MMD1_k127_5158566_2	765912.Thimo_1210	8.007e-22	102.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1WY57@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
MMD1_k127_5165116_3	1292034.OR37_03855	5.107e-28	116.0	COG0110@1|root,COG0110@2|Bacteria,1MZ7U@1224|Proteobacteria,2UBQS@28211|Alphaproteobacteria,2KJCS@204458|Caulobacterales	204458|Caulobacterales	S	TIGRFAM sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family	-	-	-	ko:K13006	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Hexapep
MMD1_k127_5165116_2	1227453.C444_19627	3.198e-36	149.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,23STH@183963|Halobacteria	183963|Halobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMD1_k127_5165116_1	316274.Haur_4322	5.873e-84	292.0	COG0399@1|root,COG0399@2|Bacteria,2G5QG@200795|Chloroflexi	200795|Chloroflexi	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMD1_k127_5165116_0	1511.CLOST_0367	1.049e-97	332.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia,25SI7@186804|Peptostreptococcaceae	186801|Clostridia	M	SAF	neuB	-	2.5.1.101,2.5.1.56	ko:K01654,ko:K18430	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
MMD1_k127_5165116_4	858215.Thexy_1873	2.074e-05	47.0	COG1083@1|root,COG1083@2|Bacteria,1UFAT@1239|Firmicutes,24G5I@186801|Clostridia,42G13@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM acylneuraminate cytidylyltransferase	neuA	-	2.7.7.82	ko:K18431	ko00520,map00520	-	R10182	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3
MMD1_k127_5172035_0	192952.MM_0593	3.539e-174	556.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMD1_k127_5172035_2	641107.CDLVIII_4827	1.484e-20	101.0	COG0500@1|root,COG2226@2|Bacteria,1V20J@1239|Firmicutes,24BSI@186801|Clostridia,36EY2@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
MMD1_k127_5172035_3	98439.AJLL01000081_gene2404	4.997e-16	85.0	COG0517@1|root,COG0517@2|Bacteria,1G49V@1117|Cyanobacteria,1JJBZ@1189|Stigonemataceae	1117|Cyanobacteria	S	CP12	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CP12
MMD1_k127_5172035_4	224719.Abm4_1307	1.613e-05	51.0	COG4009@1|root,arCOG04905@2157|Archaea,2Y0I1@28890|Euryarchaeota,23P7W@183925|Methanobacteria	183925|Methanobacteria	S	Domain of unknown function (DUF749)	-	-	-	-	-	-	-	-	-	-	-	-	DUF749
MMD1_k127_5172035_1	267377.MMP1053	4.12e-98	327.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,23Q3U@183939|Methanococci	183939|Methanococci	C	heterodisulfide reductase, subunit B	hdrB2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD1_k127_5172035_5	351160.RRC256	0.0002758	45.0	COG2048@1|root,arCOG00964@2157|Archaea,2XVUC@28890|Euryarchaeota,2NBJN@224756|Methanomicrobia	28890|Euryarchaeota	C	4Fe-4S dicluster domain	hdrC2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD1_k127_5176687_2	215803.DB30_8307	8.86e-15	90.0	COG2133@1|root,COG2133@2|Bacteria,1PEJE@1224|Proteobacteria,437VF@68525|delta/epsilon subdivisions,2X352@28221|Deltaproteobacteria,2YUAU@29|Myxococcales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4215,GSDH,Ig_3
MMD1_k127_5176687_0	717606.PaecuDRAFT_2136	6.758e-26	126.0	COG1520@1|root,COG3210@1|root,COG4412@1|root,COG5276@1|root,COG5492@1|root,COG1520@2|Bacteria,COG3210@2|Bacteria,COG4412@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,1TR9M@1239|Firmicutes,4HEPP@91061|Bacilli,26T62@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Cadherin-like,Cohesin,Invasin_D3,SLH
MMD1_k127_5176687_1	192952.MM_0019	2.132e-25	112.0	COG1373@1|root,arCOG03167@2157|Archaea,2XXQC@28890|Euryarchaeota,2NAAM@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMD1_k127_520936_0	269799.Gmet_0556	1.887e-10	74.0	COG3391@1|root,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria,43C5A@68525|delta/epsilon subdivisions,2WNBK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_521649_1	444157.Tneu_1989	1.206e-12	71.0	COG1031@1|root,arCOG01359@2157|Archaea,2XPM2@28889|Crenarchaeota	28889|Crenarchaeota	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMD1_k127_521649_0	1094980.Mpsy_1552	5.608e-114	379.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,2N946@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
MMD1_k127_5240215_1	1236689.MMALV_10340	2.85e-66	235.0	COG0175@1|root,arCOG00073@2157|Archaea,2XUPU@28890|Euryarchaeota,3F2GA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,Fer4_7,PAPS_reduct,PUA
MMD1_k127_5240215_0	1041930.Mtc_0628	9.168e-130	421.0	COG1089@1|root,arCOG01373@2157|Archaea,2XUVY@28890|Euryarchaeota,2N9AM@224756|Methanomicrobia	224756|Methanomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
MMD1_k127_5245580_0	706587.Desti_0010	1.013e-319	1020.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2MR5E@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NAD(P)-binding Rossmann-like domain	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
MMD1_k127_5245580_2	1121405.dsmv_2343	1.949e-64	250.0	COG0247@1|root,COG1908@1|root,COG0247@2|Bacteria,COG1908@2|Bacteria,1R8YC@1224|Proteobacteria,42NJW@68525|delta/epsilon subdivisions,2WIX1@28221|Deltaproteobacteria,2MIBB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Fer4_9,FlpD
MMD1_k127_5245580_1	335543.Sfum_1977	5.123e-166	551.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
MMD1_k127_5250693_3	877455.Metbo_1631	8.842e-24	104.0	COG1917@1|root,arCOG02994@2157|Archaea	2157|Archaea	JM	conserved protein, contains double-stranded beta-helix domain	-	-	1.13.11.4,4.2.1.108	ko:K00450,ko:K06720	ko00260,ko00350,ko01100,ko01120,map00260,map00350,map01100,map01120	M00033	R02656,R06979	RC00764,RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,Ectoine_synth
MMD1_k127_5250693_1	1968.JOEV01000009_gene1724	9.894e-45	170.0	COG3607@1|root,COG3607@2|Bacteria,2IKVS@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
MMD1_k127_5250693_2	593750.Metfor_2797	2.87e-40	157.0	COG3832@1|root,arCOG09481@1|root,arCOG05261@2157|Archaea,arCOG09481@2157|Archaea,2XYEH@28890|Euryarchaeota,2NAYB@224756|Methanomicrobia	224756|Methanomicrobia	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMD1_k127_5250693_0	304371.MCP_1283	4.514e-85	302.0	COG1404@1|root,arCOG00702@2157|Archaea,2XSZR@28890|Euryarchaeota,2NBHA@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	3.4.21.62	ko:K01342	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
MMD1_k127_5250693_4	589924.Ferp_0134	5.763e-10	70.0	COG3413@1|root,arCOG02271@2157|Archaea,2XU8X@28890|Euryarchaeota	28890|Euryarchaeota	K	Bacterio-opsin activator HTH domain-containing protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	BAT,HTH_10
MMD1_k127_5283516_0	234267.Acid_0433	2.636e-05	57.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMD1_k127_5287358_1	102129.Lepto7375DRAFT_4199	7.024e-07	61.0	COG0508@1|root,COG3420@1|root,COG0508@2|Bacteria,COG3420@2|Bacteria,1G3CP@1117|Cyanobacteria,1H7VY@1150|Oscillatoriales	1117|Cyanobacteria	P	parallel beta-helix repeat (two copies)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565
MMD1_k127_5287358_0	1303518.CCALI_00302	3.262e-15	78.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
MMD1_k127_5298184_11	1123252.ATZF01000027_gene1612	1.228e-07	61.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_5298184_0	1487923.DP73_14965	4.535e-122	406.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25ZZ5@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMD1_k127_5298184_5	529709.PYCH_12150	9.723e-53	204.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMD1_k127_5298184_3	477974.Daud_0678	5.505e-63	225.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,266KR@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMD1_k127_5298184_8	673860.AciM339_0745	3.079e-36	149.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,3F35C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
MMD1_k127_5298184_1	415426.Hbut_0995	3.359e-83	295.0	COG1042@1|root,arCOG01340@2157|Archaea,2XPR9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
MMD1_k127_5298184_12	1214242.B446_16965	0.0006156	49.0	COG1522@1|root,COG1522@2|Bacteria,2IG2K@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	lrp	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD1_k127_5298184_9	744980.TRICHSKD4_4380	6.752e-17	95.0	COG2931@1|root,COG2931@2|Bacteria,1QZD0@1224|Proteobacteria,2US2T@28211|Alphaproteobacteria	1224|Proteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
MMD1_k127_5298184_10	1123060.JONP01000002_gene1019	7.46e-09	66.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales	204441|Rhodospirillales	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
MMD1_k127_5298184_2	1236689.MMALV_03530	1.093e-80	278.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,3F2KY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
MMD1_k127_5298184_4	1236689.MMALV_03520	2.515e-54	192.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,3F2N2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S11	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMD1_k127_5298184_6	673860.AciM339_1559	2.726e-51	193.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,3F2KM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMD1_k127_5298184_7	439481.Aboo_1396	3.313e-43	166.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,3F2Q4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMD1_k127_5318237_1	1298864.AUEQ01000010_gene3347	3.091e-55	198.0	COG1839@1|root,COG1839@2|Bacteria,2IAR3@201174|Actinobacteria,237WT@1762|Mycobacteriaceae	201174|Actinobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
MMD1_k127_5318237_0	573064.Mefer_0827	4.276e-86	292.0	COG0152@1|root,arCOG04421@2157|Archaea,2XUKC@28890|Euryarchaeota,23Q1A@183939|Methanococci	183939|Methanococci	F	PFAM SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMD1_k127_5318237_2	246200.SPO0570	3.071e-05	56.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1PPWK@1224|Proteobacteria,2TYY3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
MMD1_k127_5321183_4	263820.PTO0304	0.0004168	52.0	COG0438@1|root,arCOG01403@2157|Archaea,2Y7C2@28890|Euryarchaeota,242FX@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMD1_k127_5321183_3	673860.AciM339_1207	6.532e-28	114.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75G@28890|Euryarchaeota,3F3FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMD1_k127_5321183_0	647113.Metok_0524	1.481e-270	852.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
MMD1_k127_5321183_2	1041930.Mtc_0083	1.184e-43	178.0	COG0619@1|root,arCOG02250@2157|Archaea,2Y0D5@28890|Euryarchaeota,2NAR1@224756|Methanomicrobia	224756|Methanomicrobia	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
MMD1_k127_5321183_1	1041930.Mtc_0084	2.103e-89	313.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7PM@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC transporter	-	-	-	ko:K00400,ko:K16786,ko:K16787	ko00680,ko01100,ko01120,ko02010,map00680,map01100,map01120,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
MMD1_k127_5324325_3	368407.Memar_0849	9.462e-82	304.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
MMD1_k127_5324325_7	573063.Metin_0715	4.713e-41	162.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,23QPQ@183939|Methanococci	183939|Methanococci	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
MMD1_k127_5324325_8	706587.Desti_5346	5.528e-38	159.0	COG0715@1|root,COG0715@2|Bacteria,1RHDX@1224|Proteobacteria,42V6G@68525|delta/epsilon subdivisions,2WRZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	iAF987.Gmet_0996	NMT1_2
MMD1_k127_5324325_6	1094980.Mpsy_2215	7.86e-45	168.0	COG4800@1|root,arCOG04375@2157|Archaea,2XXJS@28890|Euryarchaeota,2N9MB@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
MMD1_k127_5324325_2	1041930.Mtc_1082	9.584e-170	564.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMD1_k127_5324325_4	439481.Aboo_0735	1.168e-70	249.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,3F2PE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Domain in cystathionine beta-synthase and other proteins.	cbs2	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD1_k127_5324325_5	1236689.MMALV_10880	1.027e-48	189.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,3F2N3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Amidohydrolase family	guaD2	-	3.5.4.1,3.5.4.3	ko:K01485,ko:K01487	ko00230,ko00240,ko00330,ko01100,map00230,map00240,map00330,map01100	-	R00974,R01411,R01676,R02922	RC00074,RC00204,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMD1_k127_5324325_9	439481.Aboo_1092	2.147e-17	84.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y6XN@28890|Euryarchaeota,3F2S9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMD1_k127_5324325_0	439481.Aboo_1091	0.0	1534.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,3F2FW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03044,ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMD1_k127_5324325_1	673860.AciM339_1401	0.0	1158.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,3F2IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMD1_k127_5331058_2	1054217.TALC_00593	2.286e-72	253.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,241N9@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMD1_k127_5331058_0	1236689.MMALV_05610	2.986e-136	442.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,3F2GW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	hmgB	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III,ACP_syn_III_C,HMG_CoA_synt_C,HMG_CoA_synt_N
MMD1_k127_5331058_1	269797.Mbar_A0550	5.482e-129	424.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
MMD1_k127_5331058_4	673860.AciM339_0716	4.791e-40	161.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,3F2RZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	V	DUF35 OB-fold domain, acyl-CoA-associated	acaC	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMD1_k127_5331058_5	1054217.TALC_01337	1.871e-14	77.0	COG4004@1|root,arCOG04412@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5331058_7	351160.RCIX1626	0.0008836	48.0	arCOG03048@1|root,arCOG03048@2157|Archaea	2157|Archaea	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
MMD1_k127_5331058_3	1041930.Mtc_0367	1.35e-60	216.0	COG1926@1|root,arCOG00041@2157|Archaea,2XWHP@28890|Euryarchaeota,2N9V9@224756|Methanomicrobia	224756|Methanomicrobia	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
MMD1_k127_5331058_6	215803.DB30_0684	1.256e-06	62.0	COG1404@1|root,COG3291@1|root,COG3509@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG3509@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3,Inhibitor_I9,Peptidase_S8
MMD1_k127_5336420_1	1267535.KB906767_gene4825	3.882e-25	115.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria,2JHKB@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5336420_3	269797.Mbar_A0687	8.032e-07	55.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMD1_k127_5336420_0	880073.Calab_1228	1.562e-56	206.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
MMD1_k127_5336420_2	645512.GCWU000246_01273	6.892e-21	99.0	COG0424@1|root,COG0424@2|Bacteria,3TB79@508458|Synergistetes	508458|Synergistetes	D	TIGRFAM maf protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
MMD1_k127_5337093_3	649831.L083_4532	2.256e-21	102.0	COG0524@1|root,COG0524@2|Bacteria,2GKQP@201174|Actinobacteria,4DG6B@85008|Micromonosporales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
MMD1_k127_5337093_2	671143.DAMO_3119	5.517e-58	218.0	COG1893@1|root,COG1893@2|Bacteria,2NPMG@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
MMD1_k127_5337093_1	388739.RSK20926_00655	5.864e-102	359.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,2P58I@2433|Roseobacter	28211|Alphaproteobacteria	E	COG0626 Cystathionine beta-lyases cystathionine gamma-synthases	mdeA	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
MMD1_k127_5337093_0	1094980.Mpsy_1449	1.989e-116	399.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,2N9AX@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
MMD1_k127_5357125_5	235279.HH_1330	0.0002695	50.0	COG1246@1|root,COG1246@2|Bacteria,1RHT7@1224|Proteobacteria,42SGE@68525|delta/epsilon subdivisions,2YPNW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	acetyltransferase	-	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
MMD1_k127_5357125_3	394503.Ccel_1547	8.769e-09	69.0	COG1572@1|root,COG2372@1|root,COG2374@1|root,COG3940@1|root,COG4447@1|root,COG4733@1|root,COG1572@2|Bacteria,COG2372@2|Bacteria,COG2374@2|Bacteria,COG3940@2|Bacteria,COG4447@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	xynX1	-	3.1.3.8,3.2.1.89	ko:K01083,ko:K01224,ko:K07004,ko:K07156	ko00562,map00562	-	R03371	RC00078	ko00000,ko00001,ko01000,ko02000	9.B.62.2	-	-	Big_5,DUF4082,Exo_endo_phos,RicinB_lectin_2,SLH
MMD1_k127_5357125_4	1333523.L593_03300	1.878e-07	61.0	arCOG04596@1|root,arCOG04596@2157|Archaea,2XX20@28890|Euryarchaeota,23VPS@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5357125_2	670487.Ocepr_0103	4.389e-14	80.0	COG0723@1|root,COG0723@2|Bacteria,1WJBT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Rieske 2Fe-2S domain	-	-	-	ko:K15878	-	-	-	-	ko00000	-	-	-	Rieske
MMD1_k127_5357125_0	1448860.BBJO01000013_gene1022	1.04e-76	289.0	COG1290@1|root,arCOG01721@2157|Archaea,2XUQH@28890|Euryarchaeota,23TXF@183963|Halobacteria	183963|Halobacteria	C	COG1290 Cytochrome b subunit of the bc complex	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B
MMD1_k127_5357125_1	1238425.J07HQW2_03035	9.902e-25	117.0	COG1290@1|root,arCOG04594@2157|Archaea,2XUW1@28890|Euryarchaeota,23S8Q@183963|Halobacteria	183963|Halobacteria	C	COG1290 Cytochrome b subunit of the bc complex	petD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
MMD1_k127_5363284_1	1183377.Py04_1357	1.822e-59	218.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,243JH@183968|Thermococci	183968|Thermococci	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMD1_k127_5363284_0	1094980.Mpsy_0983	2.08e-88	321.0	COG1404@1|root,arCOG02538@1|root,arCOG03439@1|root,arCOG00702@2157|Archaea,arCOG02538@2157|Archaea,arCOG03439@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
MMD1_k127_5367465_0	1041930.Mtc_1668	2.804e-81	280.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	28890|Euryarchaeota	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
MMD1_k127_5367465_1	1526927.Plano_1018	4.031e-16	93.0	COG0842@1|root,COG0842@2|Bacteria,1TSWD@1239|Firmicutes,4HB6Z@91061|Bacilli,26GTA@186818|Planococcaceae	91061|Bacilli	U	ABC-2 type transporter	yadH	-	-	ko:K01992,ko:K09694	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC2_membrane
MMD1_k127_5371520_0	1303518.CCALI_00302	4.52e-157	505.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
MMD1_k127_5372341_2	529818.AMSG_03810T0	1.296e-13	87.0	COG4886@1|root,KOG0619@2759|Eukaryota	2759|Eukaryota	U	regulation of response to stimulus	-	-	-	ko:K14767,ko:K16175	ko04390,ko04391,ko04530,ko05165,ko05203,map04390,map04391,map04530,map05165,map05203	-	-	-	ko00000,ko00001,ko03009	-	-	-	LRR_6,LRR_8,PDZ,Pkinase_Tyr
MMD1_k127_5372341_1	575540.Isop_1342	6.833e-45	174.0	COG0476@1|root,COG0476@2|Bacteria,2IY9K@203682|Planctomycetes	203682|Planctomycetes	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
MMD1_k127_5372341_0	368407.Memar_1422	1.424e-64	231.0	COG2897@1|root,arCOG02019@2157|Archaea,2Y76U@28890|Euryarchaeota,2NBE7@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
MMD1_k127_5374940_5	797114.C475_08321	2.394e-14	87.0	COG3291@1|root,COG3979@1|root,arCOG02916@1|root,arCOG02510@2157|Archaea,arCOG02916@2157|Archaea,arCOG07581@2157|Archaea,2XUVP@28890|Euryarchaeota,23UBC@183963|Halobacteria	183963|Halobacteria	S	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_5374940_1	273075.Ta1100	1.692e-45	173.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,241QB@183967|Thermoplasmata	183967|Thermoplasmata	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMD1_k127_5374940_3	673860.AciM339_0905	1.708e-17	88.0	COG0640@1|root,arCOG03067@2157|Archaea,2Y747@28890|Euryarchaeota,3F3DB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMD1_k127_5374940_2	673860.AciM339_0905	1.102e-23	104.0	COG0640@1|root,arCOG03067@2157|Archaea,2Y747@28890|Euryarchaeota,3F3DB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMD1_k127_5374940_0	673860.AciM339_0890	8.103e-109	364.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,3F2GM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMD1_k127_5374940_4	29176.XP_003881633.1	3.835e-17	92.0	COG0071@1|root,KOG0710@2759|Eukaryota,3YCB3@5794|Apicomplexa,3YM5V@5796|Coccidia,3YTY4@5809|Sarcocystidae	5794|Apicomplexa	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMD1_k127_5375835_2	635013.TherJR_1124	1.759e-06	59.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
MMD1_k127_5375835_3	760568.Desku_2588	2.732e-06	59.0	COG2864@1|root,COG2864@2|Bacteria,1V26N@1239|Firmicutes,24FSJ@186801|Clostridia,261PB@186807|Peptococcaceae	186801|Clostridia	C	PFAM Cytochrome b(N-terminal) b6 petB	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
MMD1_k127_5375835_0	1054217.TALC_00487	3.802e-111	391.0	COG0277@1|root,arCOG00340@2157|Archaea,2XVP5@28890|Euryarchaeota	28890|Euryarchaeota	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
MMD1_k127_5375835_1	1236689.MMALV_16610	1.355e-41	160.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota	28890|Euryarchaeota	C	reductase	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17,Fer4_8
MMD1_k127_5381732_0	1047013.AQSP01000140_gene2469	2.655e-242	756.0	COG2986@1|root,COG2986@2|Bacteria,2NQHF@2323|unclassified Bacteria	2|Bacteria	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMD1_k127_5381732_1	1345697.M493_08290	4.738e-237	741.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,4HBK9@91061|Bacilli,1WEPJ@129337|Geobacillus	91061|Bacilli	I	Carboxyl transferase domain	yngE	-	-	-	-	-	-	-	-	-	-	iYO844.BSU18210	Carboxyl_trans
MMD1_k127_5381732_3	1200792.AKYF01000011_gene3752	8.56e-79	294.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,26VPR@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMD1_k127_5381732_5	1196029.ALIM01000034_gene1607	2.095e-21	94.0	COG0511@1|root,COG0511@2|Bacteria,1UI6N@1239|Firmicutes,4ISFM@91061|Bacilli,1ZIUY@1386|Bacillus	91061|Bacilli	I	Biotin carboxyl carrier protein	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
MMD1_k127_5381732_2	1382315.JPOI01000001_gene2603	1.408e-167	538.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HA40@91061|Bacilli,1WEIT@129337|Geobacillus	91061|Bacilli	I	Biotin carboxylase C-terminal domain	yngH	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
MMD1_k127_5381732_4	1048834.TC41_0813	2.596e-52	195.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMD1_k127_5390435_4	69293.ENSGACP00000008046	6.329e-80	279.0	COG1446@1|root,KOG1592@2759|Eukaryota,38JIS@33154|Opisthokonta,3BB1E@33208|Metazoa,3CRC6@33213|Bilateria,47ZN8@7711|Chordata,498TD@7742|Vertebrata,4A16Y@7898|Actinopterygii	33208|Metazoa	E	Si dkey-103j14.5	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
MMD1_k127_5390435_11	203119.Cthe_1235	2.9e-24	121.0	COG1470@1|root,COG2373@1|root,COG2931@1|root,COG2982@1|root,COG3210@1|root,COG3291@1|root,COG3391@1|root,COG3979@1|root,COG4733@1|root,COG5520@1|root,COG1470@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3979@2|Bacteria,COG4733@2|Bacteria,COG5520@2|Bacteria,1TQ2T@1239|Firmicutes,24EP0@186801|Clostridia,3WI1H@541000|Ruminococcaceae	186801|Clostridia	MU	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD,Paired_CXXCH_1,SLH,fn3
MMD1_k127_5390435_7	1121481.AUAS01000003_gene3739	1e-55	225.0	COG2931@1|root,COG5184@1|root,COG2931@2|Bacteria,COG5184@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
MMD1_k127_5390435_0	386456.JQKN01000001_gene2060	8.781e-132	429.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,23NMH@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
MMD1_k127_5390435_12	765913.ThidrDRAFT_0694	5.183e-12	81.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
MMD1_k127_5390435_8	1236689.MMALV_00360	1.911e-43	172.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,3F2PJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMD1_k127_5390435_1	1236689.MMALV_00370	9.476e-122	411.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,3F2I1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAB	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
MMD1_k127_5390435_10	439481.Aboo_0638	2.859e-28	131.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,3F2MP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	SIS domain	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
MMD1_k127_5390435_2	673860.AciM339_0397	1.875e-97	332.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,3F2J1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMD1_k127_5390435_9	1236689.MMALV_14490	8.852e-36	147.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,3F2MV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	argB1	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016114,GO:0016740,GO:0016772,GO:0016776,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0102043,GO:1901576	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD1_k127_5390435_3	1382306.JNIM01000001_gene2826	8.101e-82	296.0	COG1304@1|root,COG1304@2|Bacteria,2G5RF@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
MMD1_k127_5390435_5	1236689.MMALV_14510	1.477e-61	224.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,3F2QZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Polyprenyl synthetase	idsA	GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMD1_k127_5390435_6	521011.Mpal_2371	1.43e-58	231.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,2N9CR@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMD1_k127_5401747_0	1094980.Mpsy_0983	8.214e-73	280.0	COG1404@1|root,arCOG02538@1|root,arCOG03439@1|root,arCOG00702@2157|Archaea,arCOG02538@2157|Archaea,arCOG03439@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Calx-beta,Inhibitor_I9,Peptidase_S8
MMD1_k127_5401747_1	70601.3257368	4.69e-05	56.0	COG1572@1|root,COG3979@1|root,arCOG03260@1|root,arCOG03553@1|root,arCOG03610@1|root,arCOG07560@1|root,arCOG02532@2157|Archaea,arCOG03260@2157|Archaea,arCOG03553@2157|Archaea,arCOG03610@2157|Archaea,arCOG07560@2157|Archaea,arCOG07581@2157|Archaea,2XZY0@28890|Euryarchaeota,243FB@183968|Thermococci	183968|Thermococci	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD
MMD1_k127_5437759_0	439481.Aboo_0463	2.09e-51	196.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y726@28890|Euryarchaeota,3F38D@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K19576	-	-	-	-	ko00000,ko02000	2.A.1.2.10	-	-	MFS_1
MMD1_k127_545405_0	439481.Aboo_0942	4.277e-159	514.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,3F2FJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
MMD1_k127_545405_1	1449355.JQNR01000002_gene6126	3.156e-06	61.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMD1_k127_5464127_2	452652.KSE_08270	1.01e-36	145.0	COG2085@1|root,COG2085@2|Bacteria,2GMN3@201174|Actinobacteria,2M3ED@2063|Kitasatospora	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
MMD1_k127_5464127_3	368407.Memar_0458	8.086e-36	146.0	COG3413@1|root,arCOG02272@2157|Archaea	2157|Archaea	S	Bacterio-opsin activator HTH	-	-	1.5.1.40	ko:K06930,ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	BAT,HTH_10
MMD1_k127_5464127_0	525904.Tter_2612	3.096e-111	381.0	COG0477@1|root,COG2814@2|Bacteria,2NQSV@2323|unclassified Bacteria	2|Bacteria	P	Fungal trichothecene efflux pump (TRI12)	mdr	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD1_k127_5464127_1	479434.Sthe_2181	1.247e-38	162.0	COG2041@1|root,COG2041@2|Bacteria,2G76Y@200795|Chloroflexi,27XUT@189775|Thermomicrobia	189775|Thermomicrobia	S	Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
MMD1_k127_5473337_2	319224.Sputcn32_3550	3.324e-13	85.0	COG2931@1|root,COG3637@1|root,COG2931@2|Bacteria,COG3637@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2QA62@267890|Shewanellaceae	1236|Gammaproteobacteria	MQ	Dystroglycan-type cadherin domain protein	-	-	-	ko:K11005	-	-	-	-	ko00000,ko02000,ko02042	1.C.11	-	-	Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,VWA_2
MMD1_k127_5473337_1	1123320.KB889675_gene3985	6.832e-15	88.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CinA family	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
MMD1_k127_5473337_0	1123354.AUDR01000015_gene360	1.077e-44	168.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,1KRN8@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMD1_k127_5477040_1	439481.Aboo_0646	5.125e-23	102.0	COG1522@1|root,arCOG01580@2157|Archaea,2Y746@28890|Euryarchaeota,3F3D8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD1_k127_5477040_2	673860.AciM339_0164	1.993e-12	68.0	arCOG05368@1|root,arCOG05368@2157|Archaea,2Y1EG@28890|Euryarchaeota,3F2W6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5477040_0	351160.RCIX501	9.572e-105	355.0	COG0446@1|root,arCOG01069@2157|Archaea,2XT0A@28890|Euryarchaeota,2N97N@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	ndh	-	1.6.3.3	ko:K17870	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMD1_k127_5488182_0	56780.SYN_01127	6.752e-07	61.0	COG1345@1|root,COG1957@1|root,COG3204@1|root,COG1345@2|Bacteria,COG1957@2|Bacteria,COG3204@2|Bacteria,1QVAA@1224|Proteobacteria,43BPG@68525|delta/epsilon subdivisions,2X70T@28221|Deltaproteobacteria,2MR3K@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	nucleoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5497420_1	1094980.Mpsy_0731	6.651e-12	75.0	arCOG06534@1|root,arCOG06534@2157|Archaea,2Y2GI@28890|Euryarchaeota,2NAF1@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
MMD1_k127_5497420_0	506534.Rhein_4007	1.79e-41	178.0	COG2982@1|root,COG3210@1|root,COG3637@1|root,COG4932@1|root,COG2982@2|Bacteria,COG3210@2|Bacteria,COG3637@2|Bacteria,COG4932@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin_3,Calx-beta,DUF11,DUF4347,He_PIG,OmpA_membrane,PATR,VCBS
MMD1_k127_5497536_2	1161401.ASJA01000013_gene668	8.746e-07	52.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,43X2T@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMD1_k127_5497536_3	1385511.N783_04500	6.129e-06	59.0	COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,4HFDG@91061|Bacilli	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD1_k127_5497536_1	1333523.L593_10775	7.379e-18	89.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,23W5Q@183963|Halobacteria	183963|Halobacteria	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC,UBA_4
MMD1_k127_5497536_0	246969.TAM4_790	7.462e-72	252.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,242R4@183968|Thermococci	183968|Thermococci	H	Involved in the catabolism of quinolinic acid (QA)	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
MMD1_k127_553770_3	272558.10175838	8.382e-09	69.0	COG1470@1|root,COG1470@2|Bacteria,1TZ9A@1239|Firmicutes,4HD5P@91061|Bacilli,1ZE3T@1386|Bacillus	91061|Bacilli	S	NPCBM-associated, NEW3 domain of alpha-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc
MMD1_k127_553770_0	357808.RoseRS_3291	4.189e-239	748.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi,3750V@32061|Chloroflexia	32061|Chloroflexia	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
MMD1_k127_553770_1	1212548.B381_00630	2.148e-163	530.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1YZSU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG5016 Pyruvate oxaloacetate carboxyltransferase	oadA	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_5346	Biotin_lipoyl,HMGL-like,PYC_OADA
MMD1_k127_553770_2	1203606.HMPREF1526_01671	7.069e-17	87.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,36KM8@31979|Clostridiaceae	186801|Clostridia	I	Biotin-requiring enzyme	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
MMD1_k127_553770_4	868131.MSWAN_1792	2.018e-07	63.0	COG0069@1|root,arCOG00619@2157|Archaea,2Y7H6@28890|Euryarchaeota,23PHC@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the glutamate synthase family	gltA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Glu_synthase
MMD1_k127_553770_5	477974.Daud_2024	2.964e-06	58.0	COG0070@1|root,COG0070@2|Bacteria,1TQEB@1239|Firmicutes,24AQ1@186801|Clostridia,261IX@186807|Peptococcaceae	186801|Clostridia	E	PFAM glutamate synthase alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
MMD1_k127_553770_6	439481.Aboo_0541	3.488e-05	53.0	COG3430@1|root,arCOG02423@2157|Archaea	2157|Archaea	S	Pfam:DUF1628	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
MMD1_k127_553770_7	439481.Aboo_0541	0.0004899	49.0	COG3430@1|root,arCOG02423@2157|Archaea	2157|Archaea	S	Pfam:DUF1628	-	-	-	-	-	-	-	-	-	-	-	-	Pilin_N
MMD1_k127_5540640_0	78398.KS43_06410	7.94e-15	90.0	COG1853@1|root,COG2373@1|root,COG1853@2|Bacteria,COG2373@2|Bacteria,1QV7E@1224|Proteobacteria,1SM3U@1236|Gammaproteobacteria,1MSAW@122277|Pectobacterium	1236|Gammaproteobacteria	S	TIGRFAM Outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Big_3_3
MMD1_k127_5540640_2	1283300.ATXB01000001_gene2284	2.177e-08	69.0	COG3209@1|root,COG3292@1|root,COG3209@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Cu_amine_oxidN1,Tail_P2_I
MMD1_k127_5540640_1	1297742.A176_00262	4.964e-12	81.0	COG1470@1|root,COG2885@1|root,COG4719@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,COG4719@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
MMD1_k127_5540640_3	545694.TREPR_2079	3.287e-06	59.0	COG2911@1|root,COG2911@2|Bacteria,2JBJG@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
MMD1_k127_5540659_0	1459636.NTE_00007	1.398e-121	417.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
MMD1_k127_5540659_1	883126.HMPREF9710_05210	1.355e-63	230.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VKGA@28216|Betaproteobacteria,477B7@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_5540659_3	1455608.JDTH01000001_gene3684	3.019e-05	58.0	arCOG02545@1|root,arCOG02545@2157|Archaea,2Y1A4@28890|Euryarchaeota,23YHQ@183963|Halobacteria	183963|Halobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
MMD1_k127_5540659_2	326427.Cagg_1682	1.456e-24	109.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_23570	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_34
MMD1_k127_5540659_5	335543.Sfum_3502	0.0002845	49.0	COG0500@1|root,COG2226@2|Bacteria,1PFBN@1224|Proteobacteria,42RZV@68525|delta/epsilon subdivisions,2WNGD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMD1_k127_5542939_0	926569.ANT_15720	8.672e-108	370.0	COG0535@1|root,COG0535@2|Bacteria,2G5XT@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
MMD1_k127_5553496_4	593750.Metfor_1459	4.36e-12	72.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
MMD1_k127_5553496_2	1178482.BJB45_01880	1.67e-24	114.0	COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,1XJD4@135619|Oceanospirillales	135619|Oceanospirillales	P	COG1392 Phosphate transport regulator (distant homolog of PhoU)	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
MMD1_k127_5553496_0	1054217.TALC_00179	2.015e-128	434.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,241VX@183967|Thermoplasmata	183967|Thermoplasmata	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
MMD1_k127_5553496_1	1054217.TALC_00178	3.865e-42	159.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,241VC@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5553496_3	999630.TUZN_0192	8.979e-15	81.0	COG1571@1|root,arCOG01115@2157|Archaea,2XPN1@28889|Crenarchaeota	28889|Crenarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
MMD1_k127_5553671_0	180281.CPCC7001_2168	1.201e-10	72.0	COG2931@1|root,COG2931@2|Bacteria,1G2GC@1117|Cyanobacteria	1117|Cyanobacteria	Q	FG-GAP repeat	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,HemolysinCabind
MMD1_k127_5558978_1	797209.ZOD2009_00895	5.126e-15	85.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XWRN@28890|Euryarchaeota,23VH4@183963|Halobacteria	183963|Halobacteria	K	DNA binding	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMD1_k127_5558978_0	593750.Metfor_2765	1.414e-96	324.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,2N9IC@224756|Methanomicrobia	224756|Methanomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
MMD1_k127_5558978_2	404589.Anae109_0160	1.606e-14	81.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,42PGP@68525|delta/epsilon subdivisions,2WMGP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KQ	Methyltransferase type 11	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5,Methyltransf_11
MMD1_k127_5562884_0	1297742.A176_00747	4.932e-12	81.0	COG1372@1|root,COG2911@1|root,COG3209@1|root,COG1372@2|Bacteria,COG2911@2|Bacteria,COG3209@2|Bacteria,1PEID@1224|Proteobacteria,438II@68525|delta/epsilon subdivisions,2X3TD@28221|Deltaproteobacteria,2YX2B@29|Myxococcales	28221|Deltaproteobacteria	LM	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5607880_0	1382306.JNIM01000001_gene4190	2.875e-86	295.0	COG0863@1|root,COG0863@2|Bacteria,2G650@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
MMD1_k127_5607880_1	868131.MSWAN_2066	2.029e-72	258.0	COG1408@1|root,arCOG01156@2157|Archaea,2Y1DW@28890|Euryarchaeota,23PMV@183925|Methanobacteria	183925|Methanobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
MMD1_k127_5607880_2	1236689.MMALV_15520	3.979e-15	75.0	arCOG14617@1|root,arCOG14617@2157|Archaea,2Y5TW@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5619139_1	331678.Cphamn1_2337	1.167e-17	90.0	2DRSH@1|root,33CVS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_5619139_0	1054217.TALC_00431	2.087e-66	240.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,241NE@183967|Thermoplasmata	183967|Thermoplasmata	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
MMD1_k127_5619139_3	1054217.TALC_00153	7.685e-11	65.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,241PC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_Crp_2
MMD1_k127_5621392_3	1236689.MMALV_10390	5.644e-81	282.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,3F2HB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	PP-loop family	tuc1	-	2.8.1.15	ko:K21947	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
MMD1_k127_5621392_4	1220534.B655_1048	6.538e-16	94.0	arCOG02499@1|root,arCOG02501@1|root,arCOG02499@2157|Archaea,arCOG02501@2157|Archaea,2Y0FJ@28890|Euryarchaeota	28890|Euryarchaeota	O	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD
MMD1_k127_5621392_1	1457250.BBMO01000001_gene1581	1.074e-106	391.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_5621392_5	439481.Aboo_1334	1.206e-12	83.0	arCOG02498@1|root,arCOG02499@1|root,arCOG02545@1|root,arCOG02498@2157|Archaea,arCOG02499@2157|Archaea,arCOG02545@2157|Archaea,2Y6YI@28890|Euryarchaeota,3F2WY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	NosD
MMD1_k127_5621392_2	1457250.BBMO01000001_gene1581	5.42e-82	310.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_5621392_0	1121405.dsmv_2611	9.523e-161	518.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
MMD1_k127_5656823_0	1457250.BBMO01000001_gene1581	2.514e-42	170.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_5656823_1	1121479.AUBS01000002_gene3633	5.913e-31	141.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,2U12Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_5656832_3	111780.Sta7437_2551	3.846e-25	111.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,3VJQ2@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
MMD1_k127_5656832_2	429009.Adeg_1075	7.565e-98	331.0	COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,249TX@186801|Clostridia,42FIT@68295|Thermoanaerobacterales	186801|Clostridia	C	FMN-dependent alpha-hydroxy acid dehydrogenase	lldD	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
MMD1_k127_5656832_1	269797.Mbar_A0715	4.968e-121	399.0	COG0372@1|root,arCOG04237@2157|Archaea,2XT24@28890|Euryarchaeota,2NA70@224756|Methanomicrobia	224756|Methanomicrobia	C	Citrate synthase, C-terminal domain	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0715	Citrate_synt
MMD1_k127_5656832_0	867903.ThesuDRAFT_01180	6.508e-148	478.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia	186801|Clostridia	C	aconitate hydratase	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMD1_k127_5658095_1	439481.Aboo_0164	3.779e-20	92.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,3F2KN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
MMD1_k127_5658095_2	179408.Osc7112_4373	3.519e-08	64.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
MMD1_k127_5658095_0	1211777.BN77_p270040	4.874e-36	155.0	COG1657@1|root,COG1657@2|Bacteria,1MVWK@1224|Proteobacteria,2U0EZ@28211|Alphaproteobacteria,4BDD1@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
MMD1_k127_5658095_3	1343739.PAP_09865	1.34e-05	58.0	arCOG03797@1|root,arCOG03797@2157|Archaea,2Y8H0@28890|Euryarchaeota,24488@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF835)	-	-	-	-	-	-	-	-	-	-	-	-	DUF835
MMD1_k127_5665142_2	1499967.BAYZ01000191_gene3928	4.945e-05	50.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
MMD1_k127_5665142_1	926550.CLDAP_25980	5.23e-19	94.0	COG1708@1|root,COG1708@2|Bacteria,2G8N6@200795|Chloroflexi	200795|Chloroflexi	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
MMD1_k127_5665142_0	243275.TDE_0263	2.956e-38	149.0	COG1670@1|root,COG1670@2|Bacteria,2JA5U@203691|Spirochaetes	203691|Spirochaetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMD1_k127_5667294_2	1232410.KI421421_gene3533	0.0001488	53.0	COG1361@1|root,COG4719@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4719@2|Bacteria,COG4932@2|Bacteria,1PFZK@1224|Proteobacteria,437DI@68525|delta/epsilon subdivisions,2X2JM@28221|Deltaproteobacteria,43VQS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
MMD1_k127_5667294_0	1457250.BBMO01000001_gene1581	2.931e-100	360.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMD1_k127_5667294_1	292459.STH577	4.668e-47	178.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes	1239|Firmicutes	IQ	Dehydrogenase	ydaD	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMD1_k127_5692677_2	439481.Aboo_0657	6.307e-52	186.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,3F2JU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMD1_k127_5692677_1	673860.AciM339_1056	1.584e-53	201.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,3F2KS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMD1_k127_5692677_3	693661.Arcve_1550	3.326e-24	109.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y0SK@28890|Euryarchaeota,2476X@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMD1_k127_5692677_0	304371.MCP_2614	7.553e-119	389.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2N989@224756|Methanomicrobia	224756|Methanomicrobia	C	thiamine pyrophosphate enzyme domain protein TPP-binding	porB-1	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD1_k127_5701380_2	1347086.CCBA010000023_gene2064	3.081e-18	94.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli,1ZDEQ@1386|Bacillus	91061|Bacilli	O	COG1404 Subtilisin-like serine proteases	bprF	GO:0005575,GO:0005576	-	ko:K13276	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,PKD,Peptidase_M6,Peptidase_S8
MMD1_k127_5701380_0	706587.Desti_3910	6.055e-52	206.0	COG4030@1|root,COG4030@2|Bacteria	2|Bacteria	M	Protein of unknown function (DUF2961)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2961
MMD1_k127_5701380_1	429009.Adeg_0902	5.292e-31	132.0	COG0524@1|root,COG0524@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,42EVE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM PfkB domain protein	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
MMD1_k127_5706601_0	56107.Cylst_6024	2.743e-42	161.0	COG1881@1|root,COG1881@2|Bacteria,1G5SZ@1117|Cyanobacteria,1HN4E@1161|Nostocales	1117|Cyanobacteria	S	TIGRFAM Raf kinase inhibitor-like protein, YbhB YbcL family	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
MMD1_k127_5706601_1	1205680.CAKO01000010_gene3825	0.0004761	48.0	COG2411@1|root,COG2411@2|Bacteria,1N0KG@1224|Proteobacteria,2UCPX@28211|Alphaproteobacteria,2JX0N@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_572791_9	439481.Aboo_1514	7.323e-15	76.0	COG0255@1|root,arCOG00785@2157|Archaea,2Y1DQ@28890|Euryarchaeota,3F2VT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal L29 protein	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMD1_k127_572791_5	1236689.MMALV_14180	5.549e-37	145.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,3F2TV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Translation initiation factor SUI1	tif1a	GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
MMD1_k127_572791_10	644281.MFS40622_1734	2.557e-12	74.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23R70@183939|Methanococci	183939|Methanococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
MMD1_k127_572791_6	456442.Mboo_0541	2.722e-30	124.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,2N9XI@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMD1_k127_572791_3	439481.Aboo_1511	9.007e-53	188.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMD1_k127_572791_7	272557.APE_0358	9.913e-30	122.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
MMD1_k127_572791_0	439481.Aboo_1509	2.025e-56	207.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,3F2KF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal family S4e	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
MMD1_k127_572791_2	1054217.TALC_01321	2.4e-54	207.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,241QF@183967|Thermoplasmata	183967|Thermoplasmata	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMD1_k127_572791_8	1236689.MMALV_14120	1.899e-15	88.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y68V@28890|Euryarchaeota,3F2V3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S14	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMD1_k127_572791_4	439481.Aboo_1506	5.013e-51	184.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,3F2NR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMD1_k127_572791_1	439481.Aboo_1505	2.143e-56	201.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,3F2ND@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMD1_k127_5745771_0	1121904.ARBP01000051_gene3638	2.569e-05	59.0	COG3291@1|root,COG3291@2|Bacteria,4NJ9V@976|Bacteroidetes,47N8F@768503|Cytophagia	976|Bacteroidetes	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PKD
MMD1_k127_5753730_0	1449126.JQKL01000018_gene3293	1.211e-114	382.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,267YE@186813|unclassified Clostridiales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMD1_k127_5753730_1	1256908.HMPREF0373_00674	6.536e-07	54.0	COG3292@1|root,COG3292@2|Bacteria,1UICX@1239|Firmicutes,24ABD@186801|Clostridia	186801|Clostridia	T	Psort location Extracellular, score	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3
MMD1_k127_5757699_1	304371.MCP_0638	7.221e-63	226.0	COG0175@1|root,COG1145@1|root,arCOG00073@2157|Archaea,arCOG02179@2157|Archaea,2XUPU@28890|Euryarchaeota,2N9A2@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM PUA domain	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0559	Fer4,Fer4_10,PAPS_reduct,PUA
MMD1_k127_5757699_3	1476876.JOJO01000002_gene6411	9.448e-34	140.0	COG1618@1|root,COG1618@2|Bacteria,2IJWQ@201174|Actinobacteria	201174|Actinobacteria	F	NTPase	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMD1_k127_5757699_2	521011.Mpal_1938	2.918e-54	201.0	COG0301@1|root,arCOG00038@2157|Archaea,2XYMB@28890|Euryarchaeota,2NBHY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiI
MMD1_k127_5757699_0	521011.Mpal_1940	1.216e-65	237.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
MMD1_k127_5757699_4	410358.Mlab_1392	2.988e-10	66.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
MMD1_k127_5759648_0	439481.Aboo_1077	1.042e-142	464.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,3F2IF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMD1_k127_5759648_1	69014.TK0305	4.62e-52	191.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,242XX@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD1_k127_5809165_0	593750.Metfor_1801	4.558e-25	110.0	COG1895@1|root,arCOG02123@2157|Archaea,2Y56Q@28890|Euryarchaeota	28890|Euryarchaeota	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
MMD1_k127_5809165_1	593750.Metfor_1800	7.135e-21	101.0	COG1708@1|root,arCOG01208@2157|Archaea	2157|Archaea	S	DNA polymerase beta	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
MMD1_k127_5816075_2	342949.PNA2_1011	6.44e-07	61.0	arCOG01314@1|root,arCOG01314@2157|Archaea,2XVNC@28890|Euryarchaeota,243S2@183968|Thermococci	183968|Thermococci	S	Domain of unknown function (DUF4350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
MMD1_k127_5816075_4	31234.CRE13870	0.0007406	53.0	COG0353@1|root,2R5W4@2759|Eukaryota,39H2B@33154|Opisthokonta,3CKWG@33208|Metazoa,3E2GZ@33213|Bilateria,40Q5V@6231|Nematoda,1M7PD@119089|Chromadorea,416B3@6236|Rhabditida	33208|Metazoa	L	RecR protein	-	-	-	-	-	-	-	-	-	-	-	-	RecR
MMD1_k127_5816075_3	1353276.JADR01000002_gene1973	0.0006337	54.0	COG3291@1|root,COG4412@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4412@2|Bacteria,COG4935@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	CHU_C,Cleaved_Adhesin,Peptidase_M30,fn3
MMD1_k127_5816075_0	1236689.MMALV_16220	1.514e-71	251.0	COG1351@1|root,arCOG01883@2157|Archaea,2XY5D@28890|Euryarchaeota,3F2NG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
MMD1_k127_5816075_1	589924.Ferp_0246	9.925e-36	150.0	COG1624@1|root,arCOG04453@2157|Archaea,2XTR1@28890|Euryarchaeota,2464E@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a	dacZ	-	-	-	-	-	-	-	-	-	-	-	DisA_N
MMD1_k127_596631_4	28042.GU90_00250	5.811e-13	79.0	COG3703@1|root,COG3703@2|Bacteria,2GJM9@201174|Actinobacteria,4E2N8@85010|Pseudonocardiales	201174|Actinobacteria	P	AIG2-like family	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
MMD1_k127_596631_0	379066.GAU_1670	1.348e-111	370.0	COG0039@1|root,COG0039@2|Bacteria,1ZSV3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
MMD1_k127_596631_3	1227457.C451_14640	9.73e-60	220.0	COG0697@1|root,arCOG00271@2157|Archaea,2XT64@28890|Euryarchaeota,23TZT@183963|Halobacteria	183963|Halobacteria	G	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMD1_k127_596631_2	1117319.PSPO_21164	2.773e-76	293.0	COG1404@1|root,COG5183@1|root,COG1404@2|Bacteria,COG5183@2|Bacteria,1MW57@1224|Proteobacteria,1SZIX@1236|Gammaproteobacteria,2Q5F3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	AO	COG1404 Subtilisin-like serine proteases	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Peptidase_S8
MMD1_k127_596631_1	391612.CY0110_15537	4.096e-81	308.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1G1I0@1117|Cyanobacteria,3KK8R@43988|Cyanothece	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,Lectin_C
MMD1_k127_596901_2	156889.Mmc1_3694	1.384e-08	70.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,DUF4347,FG-GAP,He_PIG,HemolysinCabind,Hint_2
MMD1_k127_596901_1	63737.Npun_R6586	1.894e-11	79.0	COG2706@1|root,COG2706@2|Bacteria,1G8VQ@1117|Cyanobacteria,1HTQN@1161|Nostocales	1117|Cyanobacteria	G	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,Lactonase
MMD1_k127_596901_0	1123508.JH636453_gene5808	3.54e-17	98.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,2J08H@203682|Planctomycetes	203682|Planctomycetes	J	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
MMD1_k127_599175_1	1094980.Mpsy_1916	1.714e-117	389.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9G6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMD1_k127_599175_0	1123392.AQWL01000005_gene3204	6.127e-168	543.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,1KRCP@119069|Hydrogenophilales	119069|Hydrogenophilales	F	AICARFT/IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
MMD1_k127_599175_3	1121920.AUAU01000039_gene1425	6.218e-12	79.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.1.3.5,3.2.1.14	ko:K01081,ko:K01183,ko:K20276	ko00230,ko00240,ko00520,ko00760,ko01100,ko01110,ko02024,map00230,map00240,map00520,map00760,map01100,map01110,map02024	-	R00183,R00511,R00963,R01126,R01206,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02334,R02719,R03346	RC00017,RC00467	ko00000,ko00001,ko01000	-	GH18	-	F5_F8_type_C,Melibiase_2,NPCBM_assoc,PKD,PPC,Trypsin_2,VPEP
MMD1_k127_599175_2	590998.Celf_3038	1.368e-23	118.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
MMD1_k127_604531_0	1094980.Mpsy_3151	5.582e-136	483.0	COG5520@1|root,arCOG03769@1|root,arCOG07561@1|root,arCOG03769@2157|Archaea,arCOG07561@2157|Archaea,arCOG09138@2157|Archaea,2XV3J@28890|Euryarchaeota,2NBAU@224756|Methanomicrobia	224756|Methanomicrobia	K	glycoside hydrolase, family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_609781_1	1125863.JAFN01000001_gene2513	2.916e-92	327.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	pfam abc1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,RIO1
MMD1_k127_609781_3	1172188.KB911820_gene2425	4.239e-40	167.0	COG4409@1|root,COG4409@2|Bacteria,2IDDY@201174|Actinobacteria,4FH84@85021|Intrasporangiaceae	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD1_k127_609781_0	439481.Aboo_1224	7.231e-115	385.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,3F2GG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMD1_k127_609781_2	694429.Pyrfu_0957	1.354e-42	179.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
MMD1_k127_620497_1	436308.Nmar_1073	1.599e-11	78.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
MMD1_k127_620497_0	1183438.GKIL_1369	8.824e-76	286.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD1_k127_67057_0	99598.Cal7507_2710	2.249e-06	60.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1HMYH@1161|Nostocales	1117|Cyanobacteria	M	COGs COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
MMD1_k127_676960_1	1122939.ATUD01000009_gene3088	7.679e-28	122.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4CSBE@84995|Rubrobacteria	84995|Rubrobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMD1_k127_676960_2	387092.NIS_0020	1.668e-18	94.0	COG0725@1|root,COG0725@2|Bacteria,1QD9D@1224|Proteobacteria,42QRE@68525|delta/epsilon subdivisions,2YQ3W@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
MMD1_k127_676960_0	351160.RCIX1096	2.963e-55	202.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota,2NB35@224756|Methanomicrobia	224756|Methanomicrobia	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMD1_k127_690428_0	519442.Huta_1389	1.754e-10	65.0	COG0467@1|root,arCOG01173@2157|Archaea,2XTF1@28890|Euryarchaeota,23U2I@183963|Halobacteria	183963|Halobacteria	T	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD1_k127_690428_1	251229.Chro_0419	1.314e-06	61.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,3VIP9@52604|Pleurocapsales	1117|Cyanobacteria	M	peptidoglycan-associated (lipo)protein	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	BON,OmpA
MMD1_k127_711821_0	857087.Metme_3901	1.68e-55	214.0	COG2202@1|root,COG4251@1|root,COG5278@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd
MMD1_k127_718399_1	1236689.MMALV_16430	9.226e-42	157.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,3F2IK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMD1_k127_718399_0	439481.Aboo_1089	5.776e-122	409.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,3F2IB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Intein_splicing,LAGLIDADG_3,RNA_pol_Rpb1_5
MMD1_k127_718399_2	1041930.Mtc_2148	1.386e-19	92.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,2NA2A@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
MMD1_k127_718399_3	1236689.MMALV_16400	1.341e-15	83.0	COG0195@1|root,arCOG01760@2157|Archaea,2Y6CH@28890|Euryarchaeota,3F2TQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5
MMD1_k127_718399_4	1211815.CBYP010000024_gene1540	0.0004167	46.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4ETCD@85013|Frankiales	201174|Actinobacteria	S	Laminin G domain	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
MMD1_k127_727663_0	251221.35214774	2.256e-75	290.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,TIG,VCBS
MMD1_k127_727663_1	436308.Nmar_1073	1.375e-50	209.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
MMD1_k127_731703_0	1220534.B655_1786	6.762e-70	246.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,23NNW@183925|Methanobacteria	183925|Methanobacteria	C	Isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMD1_k127_737816_0	1254432.SCE1572_28075	4.336e-17	96.0	COG5555@1|root,COG5555@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,VCBS
MMD1_k127_741223_1	322710.Avin_00600	5.286e-15	79.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	(ABC) transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD1_k127_741223_0	880073.Calab_2183	7.163e-17	96.0	COG3210@1|root,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,Calx-beta,DUF5122,Haemagg_act,HemolysinCabind,PPC,VCBS
MMD1_k127_750773_0	264462.Bd0328	1.071e-71	265.0	COG0457@1|root,COG0457@2|Bacteria,1QY1G@1224|Proteobacteria,43C8T@68525|delta/epsilon subdivisions,2MUD4@213481|Bdellovibrionales,2X7J5@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
MMD1_k127_761608_0	1146883.BLASA_0770	3.483e-33	146.0	COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria	201174|Actinobacteria	P	PFAM PKD domain containing protein	wcoG	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PKD
MMD1_k127_761608_1	1517682.HW49_04135	0.0005953	46.0	COG2865@1|root,COG2865@2|Bacteria,4NHJM@976|Bacteroidetes,2G2D3@200643|Bacteroidia,22XGV@171551|Porphyromonadaceae	976|Bacteroidetes	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
MMD1_k127_806156_0	1123320.KB889668_gene3380	6.252e-09	70.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	3.4.11.5	ko:K01259,ko:K06889,ko:K21193	ko00330,ko01059,map00330,map01059	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1,Abhydrolase_6,DUF2048
MMD1_k127_806156_1	1216007.AOPM01000024_gene2976	4.711e-06	60.0	COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,1T24R@1236|Gammaproteobacteria,2Q1JJ@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	U	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Big_3_3
MMD1_k127_807303_1	589924.Ferp_0942	2.538e-42	169.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,245SC@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_17
MMD1_k127_807303_0	370438.PTH_1881	4.259e-50	198.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,2607H@186807|Peptococcaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMD1_k127_831583_1	1304866.K413DRAFT_2700	6.909e-14	81.0	COG0655@1|root,COG0655@2|Bacteria,1V1FU@1239|Firmicutes,24FWC@186801|Clostridia,36SUK@31979|Clostridiaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD1_k127_831583_0	1382356.JQMP01000003_gene2339	5.348e-235	750.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi,27XME@189775|Thermomicrobia	189775|Thermomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
MMD1_k127_845339_0	439481.Aboo_0029	1.345e-59	216.0	COG2220@1|root,arCOG00497@2157|Archaea,2XZBG@28890|Euryarchaeota,3F2Q1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
MMD1_k127_845339_3	351160.RCIX1042	1.894e-52	192.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,2N9JT@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMD1_k127_845339_6	439481.Aboo_0027	1.491e-18	88.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,3F2SS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
MMD1_k127_845339_7	195522.BD01_0846	3.348e-08	62.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota,244NC@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMD1_k127_845339_5	1236689.MMALV_07990	1.066e-25	110.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,3F2TE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Belongs to the PDCD5 family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
MMD1_k127_845339_4	439481.Aboo_0024	6.996e-47	174.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,3F2P6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMD1_k127_845339_1	693661.Arcve_1306	4.572e-58	216.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2463A@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMD1_k127_845339_2	1151117.AJLF01000001_gene1614	1.487e-54	203.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,2439X@183968|Thermococci	183968|Thermococci	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
MMD1_k127_847077_3	1183377.Py04_1052	0.0003438	51.0	COG2510@1|root,arCOG03427@2157|Archaea,2Y3V3@28890|Euryarchaeota,244EW@183968|Thermococci	183968|Thermococci	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
MMD1_k127_847077_2	357804.Ping_0248	1.865e-05	53.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0044877,GO:0051704,GO:0070051,GO:0098630,GO:0098743	-	ko:K13732,ko:K13733	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Collagen_bind,Gram_pos_anchor,HemolysinCabind,MucBP,SdrG_C_C,YSIRK_signal
MMD1_k127_847077_1	192952.MM_1902	7.604e-46	172.0	COG1247@1|root,arCOG00830@2157|Archaea,2XXA1@28890|Euryarchaeota,2NAY3@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
MMD1_k127_847077_0	1121430.JMLG01000004_gene898	1.317e-123	424.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes	1239|Firmicutes	C	binding domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,Pyr_redox_2
MMD1_k127_850743_8	926560.KE387023_gene1413	1.532e-09	69.0	COG3693@1|root,COG3828@1|root,COG3693@2|Bacteria,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM9_1,CBM_2,CBM_3,CBM_4_9,CBM_6,Glyco_hydro_10,Glyco_hydro_48,Ricin_B_lectin,VCBS,fn3
MMD1_k127_850743_5	268739.Nmlp_3288	5.199e-33	146.0	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23SYZ@183963|Halobacteria	183963|Halobacteria	M	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
MMD1_k127_850743_3	471852.Tcur_3153	9.652e-40	166.0	COG1357@1|root,COG1409@1|root,COG2319@1|root,COG5635@1|root,COG1357@2|Bacteria,COG1409@2|Bacteria,COG2319@2|Bacteria,COG5635@2|Bacteria,2GJN3@201174|Actinobacteria,4EG08@85012|Streptosporangiales	201174|Actinobacteria	M	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,Pentapeptide,TIR_2,Trypsin_2,WD40
MMD1_k127_850743_7	1254432.SCE1572_34500	4.269e-11	76.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM_25,Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP,SLH,VCBS
MMD1_k127_850743_4	1172190.M947_03105	6.02e-37	153.0	COG0348@1|root,COG0348@2|Bacteria,1Q4BA@1224|Proteobacteria,42Q02@68525|delta/epsilon subdivisions,2YR7B@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10,Fer4_5
MMD1_k127_850743_0	370438.PTH_0578	1.1e-84	309.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,2609U@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
MMD1_k127_850743_2	387631.Asulf_01054	8.969e-54	199.0	COG1924@1|root,arCOG02678@2157|Archaea,2XVMQ@28890|Euryarchaeota,245WU@183980|Archaeoglobi	183980|Archaeoglobi	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
MMD1_k127_850743_1	247490.KSU1_C1240	2.907e-65	243.0	COG1924@1|root,COG1924@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
MMD1_k127_850743_6	237368.SCABRO_03564	3.626e-23	116.0	COG3291@1|root,COG3291@2|Bacteria,2J1GZ@203682|Planctomycetes	203682|Planctomycetes	U	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD1_k127_858198_0	604354.TSIB_1195	6.986e-39	149.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2433G@183968|Thermococci	183968|Thermococci	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMD1_k127_858198_1	756067.MicvaDRAFT_1602	9.476e-11	73.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
MMD1_k127_876343_0	63737.Npun_R6586	1.222e-23	119.0	COG2706@1|root,COG2706@2|Bacteria,1G8VQ@1117|Cyanobacteria,1HTQN@1161|Nostocales	1117|Cyanobacteria	G	FG-GAP repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114,Lactonase
MMD1_k127_87733_1	439481.Aboo_1126	7.215e-65	229.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,3F2K4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMD1_k127_87733_0	667014.Thein_0953	3.47e-71	248.0	COG0177@1|root,COG0177@2|Bacteria,2GH3R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
MMD1_k127_87733_2	459349.CLOAM0018	3.402e-18	100.0	COG1361@1|root,COG3420@1|root,COG1361@2|Bacteria,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_35,CBM_6,DUF11,SdrD_B
MMD1_k127_87733_3	28072.Nos7524_5484	2.229e-05	58.0	COG2304@1|root,COG3209@1|root,COG3210@1|root,COG3266@1|root,COG5276@1|root,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3266@2|Bacteria,COG5276@2|Bacteria,1G4UG@1117|Cyanobacteria	1117|Cyanobacteria	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
MMD1_k127_891894_1	909663.KI867150_gene2625	3.153e-46	182.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WJAM@28221|Deltaproteobacteria,2MRBY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
MMD1_k127_891894_0	1123371.ATXH01000018_gene1387	1.613e-57	211.0	COG1121@1|root,COG1121@2|Bacteria,2GHGE@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
MMD1_k127_891894_2	1157490.EL26_19780	2.946e-40	160.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,4H9UN@91061|Bacilli,278FS@186823|Alicyclobacillaceae	91061|Bacilli	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
MMD1_k127_925914_1	314285.KT71_18736	0.0003218	54.0	COG1404@1|root,COG1520@1|root,COG3209@1|root,COG3291@1|root,COG3391@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	rhs family	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
MMD1_k127_925914_0	269797.Mbar_A3154	1.311e-09	72.0	COG1520@1|root,arCOG02482@2157|Archaea	2157|Archaea	G	COG1520 FOG WD40-like repeat	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	ASH,DUF1573,PQQ_2,PQQ_3
MMD1_k127_926994_0	1304872.JAGC01000005_gene2126	1.037e-88	316.0	COG3118@1|root,COG3118@2|Bacteria,1QTZ9@1224|Proteobacteria,43D80@68525|delta/epsilon subdivisions,2X8EN@28221|Deltaproteobacteria,2MHHB@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotrans
MMD1_k127_937344_2	1123405.AUMM01000022_gene1907	1.115e-12	83.0	COG1404@1|root,COG3291@1|root,COG4412@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,COG4412@2|Bacteria,1TPH1@1239|Firmicutes,4HBQH@91061|Bacilli,26PY1@186821|Sporolactobacillaceae	91061|Bacilli	O	Subtilase family	prtP	-	3.4.21.96	ko:K01361	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	FIVAR,Gram_pos_anchor,Inhibitor_I9,PA,Peptidase_S8,SLAP,fn3_5
MMD1_k127_937344_1	903818.KI912269_gene147	4.36e-22	115.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DctA-YdbH,TamB
MMD1_k127_937344_0	452637.Oter_3066	1.139e-30	143.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	DctA-YdbH
MMD1_k127_941469_1	888050.HMPREF9004_1201	0.0005763	44.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4D4FJ@85005|Actinomycetales	201174|Actinobacteria	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD1_k127_941469_0	720554.Clocl_2209	4.599e-08	63.0	COG4393@1|root,COG4393@2|Bacteria,1V670@1239|Firmicutes,24HZF@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
## 1962 queries scanned
## Total time (seconds): 122.83594346046448
## Rate: 15.97 q/s