## Tue Oct 15 22:25:31 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/MMD2_bin.28.fa -m mmseqs --itype genome -o MMD2_bin.28 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/MMD2_bin.28 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMD2_k127_1008010_2	572546.Arcpr_0040	1.448e-34	145.0	COG0419@1|root,COG1245@1|root,arCOG00373@1|root,arCOG00187@2157|Archaea,arCOG00368@2157|Archaea,arCOG00373@2157|Archaea,2Y7WF@28890|Euryarchaeota,247I3@183980|Archaeoglobi	183980|Archaeoglobi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMD2_k127_1008010_3	1499967.BAYZ01000033_gene1075	1.696e-29	127.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
MMD2_k127_1008010_1	273116.14324616	2.819e-58	210.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMD2_k127_1008010_0	1459636.NTE_01677	3.193e-59	221.0	COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
MMD2_k127_1044177_0	593117.TGAM_0123	1.041e-142	456.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,24348@183968|Thermococci	183968|Thermococci	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
MMD2_k127_1044177_10	1191523.MROS_1472	1.504e-19	94.0	COG1430@1|root,COG1430@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
MMD2_k127_1044177_3	186497.PF0595	8.212e-41	160.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,242XM@183968|Thermococci	183968|Thermococci	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
MMD2_k127_1044177_9	224325.AF_1130	9.651e-20	89.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,247CZ@183980|Archaeoglobi	183980|Archaeoglobi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMD2_k127_1044177_5	420247.Msm_1431	4.221e-29	124.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMD2_k127_1044177_8	579137.Metvu_1632	2.615e-22	106.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,23QXD@183939|Methanococci	183939|Methanococci	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMD2_k127_1044177_6	573064.Mefer_0486	1.182e-25	110.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,23R1N@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
MMD2_k127_1044177_4	224325.AF_0404	1.085e-39	162.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2463R@183980|Archaeoglobi	183980|Archaeoglobi	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMD2_k127_1044177_7	693977.Deipr_2022	2.377e-25	116.0	COG1408@1|root,COG1408@2|Bacteria,1WJWG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
MMD2_k127_1044177_11	935837.JAEK01000008_gene3401	2.658e-13	78.0	COG0668@1|root,COG0668@2|Bacteria,1TQXJ@1239|Firmicutes,4HCK2@91061|Bacilli,1ZF3F@1386|Bacillus	91061|Bacilli	M	Conserved TM helix	ygxB	-	-	-	-	-	-	-	-	-	-	-	TM_helix
MMD2_k127_1044177_1	1220534.B655_1556	8.552e-96	324.0	arCOG06074@1|root,arCOG06074@2157|Archaea,2XXIH@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1044177_2	1379698.RBG1_1C00001G0708	2.987e-70	247.0	COG0010@1|root,COG0010@2|Bacteria,2NPGU@2323|unclassified Bacteria	2|Bacteria	E	Arginase family	speB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMD2_k127_111598_3	1459636.NTE_02673	2.995e-21	102.0	arCOG01449@1|root,arCOG01449@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_111598_1	247490.KSU1_C0054	1.732e-46	174.0	COG2231@1|root,COG2231@2|Bacteria,2IZ9A@203682|Planctomycetes	203682|Planctomycetes	L	endonuclease III	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
MMD2_k127_111598_2	529709.PYCH_06820	2.565e-33	143.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,242ZH@183968|Thermococci	183968|Thermococci	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMD2_k127_111598_0	589924.Ferp_2443	6.233e-63	227.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,245Q7@183980|Archaeoglobi	183980|Archaeoglobi	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMD2_k127_1137205_11	693661.Arcve_0964	1.129e-10	65.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,2464S@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosomal protein L30	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMD2_k127_1137205_0	573064.Mefer_0676	1.011e-60	216.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,23QAX@183939|Methanococci	183939|Methanococci	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMD2_k127_1137205_6	439481.Aboo_1502	1.357e-27	117.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,3F2QM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
MMD2_k127_1137205_7	529709.PYCH_01560	3.846e-20	96.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,243Y0@183968|Thermococci	183968|Thermococci	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
MMD2_k127_1137205_9	593750.Metfor_2638	2.424e-18	91.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,2N9TN@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Ribosomal protein	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
MMD2_k127_1137205_4	351160.RCIX2562	1.239e-36	143.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,2N9KP@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMD2_k127_1137205_5	339860.Msp_0893	1.37e-33	133.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,23P1I@183925|Methanobacteria	183925|Methanobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMD2_k127_1137205_12	5786.XP_003294453.1	8.349e-09	65.0	COG0199@1|root,KOG3506@2759|Eukaryota,3X9AF@554915|Amoebozoa	554915|Amoebozoa	J	Ribosomal protein S29	-	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02980	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMD2_k127_1137205_2	593750.Metfor_2642	1.271e-41	158.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,2N9KJ@224756|Methanomicrobia	224756|Methanomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMD2_k127_1137205_1	339860.Msp_0896	3.624e-42	163.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,23NT9@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
MMD2_k127_1137205_10	589924.Ferp_1147	6.615e-13	76.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,2474C@183980|Archaeoglobi	183980|Archaeoglobi	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
MMD2_k127_1137205_3	693661.Arcve_0975	1.441e-39	151.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,2467B@183980|Archaeoglobi	183980|Archaeoglobi	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMD2_k127_1137205_8	224325.AF_1916	4.593e-19	89.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,24740@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMD2_k127_1137205_14	439375.Oant_4345	0.0005438	52.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2TQTC@28211|Alphaproteobacteria,1J227@118882|Brucellaceae	28211|Alphaproteobacteria	P	Periplasmic copper-binding protein (NosD)	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
MMD2_k127_1137205_13	1303518.CCALI_00374	2.49e-05	54.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
MMD2_k127_1145069_6	868131.MSWAN_0269	3.655e-05	56.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
MMD2_k127_1145069_3	304371.MCP_0627	9.991e-19	96.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2N9X2@224756|Methanomicrobia	224756|Methanomicrobia	L	Segregation and condensation protein ScpA	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMD2_k127_1145069_0	944481.JAFP01000001_gene111	1.19e-129	429.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2M6Y2@213113|Desulfurellales	28221|Deltaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMD2_k127_1145069_2	272844.PAB1366	3.075e-23	111.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2433D@183968|Thermococci	183968|Thermococci	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
MMD2_k127_1145069_5	391623.TERMP_00169	5.399e-10	66.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,244D1@183968|Thermococci	183968|Thermococci	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044464,GO:0071840	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMD2_k127_1145069_4	1343739.PAP_02080	3.992e-13	72.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMD2_k127_1145069_1	69014.TK1633	3.074e-41	157.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMD2_k127_1190213_0	391623.TERMP_01704	2.449e-48	192.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,243BT@183968|Thermococci	183968|Thermococci	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMD2_k127_1190213_1	634498.mru_1721	8.077e-28	126.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,23NZ5@183925|Methanobacteria	183925|Methanobacteria	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMD2_k127_1204478_2	589924.Ferp_2478	3.028e-09	69.0	arCOG02545@1|root,arCOG03906@1|root,arCOG02545@2157|Archaea,arCOG03906@2157|Archaea	2157|Archaea	DZ	metallopeptidase activity	csg	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
MMD2_k127_1204478_0	1123242.JH636434_gene3679	2.95e-253	808.0	COG0474@1|root,COG0474@2|Bacteria,2IYQI@203682|Planctomycetes	203682|Planctomycetes	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD2_k127_1204478_1	439481.Aboo_1084	6.084e-87	301.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,3F2H8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
MMD2_k127_1208435_6	1459636.NTE_01636	3.824e-18	91.0	COG0615@1|root,arCOG03924@1|root,arCOG01222@2157|Archaea,arCOG03924@2157|Archaea,41SPR@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Cytidylyltransferase-like	-	-	2.7.7.2,2.7.7.39	ko:K00980,ko:K14656	ko00564,ko00740,ko01100,ko01110,map00564,map00740,map01100,map01110	-	R00161,R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMD2_k127_1208435_0	273063.STK_15110	1.177e-60	213.0	COG1839@1|root,arCOG04298@2157|Archaea,2XQ7K@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
MMD2_k127_1208435_3	153721.MYP_3119	2.542e-41	159.0	COG0262@1|root,COG0262@2|Bacteria,4NPX6@976|Bacteroidetes,47RPC@768503|Cytophagia	976|Bacteroidetes	H	RibD C-terminal domain	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
MMD2_k127_1208435_2	679926.Mpet_1639	1.295e-42	165.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y4MT@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
MMD2_k127_1208435_4	523841.HFX_2454	2.409e-36	144.0	COG3358@1|root,arCOG04570@2157|Archaea,2XWQ3@28890|Euryarchaeota,23V6T@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
MMD2_k127_1208435_7	1169143.KB911056_gene2547	1.009e-09	69.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VR04@28216|Betaproteobacteria,1KH4M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
MMD2_k127_1208435_1	436114.SYO3AOP1_1210	2.053e-54	211.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
MMD2_k127_1210042_1	1151117.AJLF01000002_gene363	1.63e-34	143.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,242WG@183968|Thermococci	183968|Thermococci	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMD2_k127_1210042_0	671143.DAMO_1602	7.175e-39	154.0	COG1814@1|root,COG1814@2|Bacteria,2NPJP@2323|unclassified Bacteria	2|Bacteria	S	VIT family	MA20_19235	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
MMD2_k127_1210042_2	399549.Msed_0162	8.658e-05	49.0	COG0433@1|root,arCOG05935@2157|Archaea,2XQ29@28889|Crenarchaeota	28889|Crenarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	AAA_10,DUF853,DUF87
MMD2_k127_1223051_0	933801.Ahos_0976	4.058e-158	507.0	COG0180@1|root,arCOG01887@2157|Archaea,2XPK1@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMD2_k127_1223051_2	1304284.L21TH_1846	8.425e-29	123.0	COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,36EFT@31979|Clostridiaceae	186801|Clostridia	S	O-methyltransferase	yrrM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
MMD2_k127_1223051_1	700598.Niako_1653	9.171e-38	145.0	COG1881@1|root,COG1881@2|Bacteria,4NH14@976|Bacteroidetes	976|Bacteroidetes	S	TIGRFAM Raf kinase inhibitor-like protein, YbhB YbcL family	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
MMD2_k127_123216_5	523845.AQXV01000045_gene1385	3.428e-17	94.0	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,23Q30@183939|Methanococci	183939|Methanococci	S	signal transduction protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD2_k127_123216_6	419665.Maeo_1104	2.683e-08	62.0	COG1814@1|root,arCOG01091@2157|Archaea,2XVWH@28890|Euryarchaeota,23QW0@183939|Methanococci	183939|Methanococci	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
MMD2_k127_123216_2	485913.Krac_5374	2.956e-81	285.0	COG0044@1|root,COG0044@2|Bacteria,2G640@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMD2_k127_123216_3	485913.Krac_3329	1.899e-74	273.0	COG1222@1|root,COG1222@2|Bacteria	2|Bacteria	O	protein catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	AAA,TPR_19,TPR_8
MMD2_k127_123216_0	243232.MJ_0232	6.741e-137	446.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23QNJ@183939|Methanococci	183939|Methanococci	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMD2_k127_123216_1	1151117.AJLF01000002_gene186	5.328e-86	294.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
MMD2_k127_123216_4	420247.Msm_1473	7.722e-59	214.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,23NXG@183925|Methanobacteria	183925|Methanobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMD2_k127_123216_7	1094980.Mpsy_2672	1.698e-06	59.0	arCOG06717@1|root,arCOG06717@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_123216_8	3055.EDO97743	0.0002436	54.0	COG4870@1|root,KOG1543@2759|Eukaryota	2759|Eukaryota	O	cysteine-type peptidase activity	-	-	3.4.18.1,3.4.22.15	ko:K01365,ko:K08568,ko:K16292	ko04140,ko04142,ko04145,ko04210,ko04612,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I29,Peptidase_C1
MMD2_k127_1245295_1	1033806.HTIA_0364	1.594e-87	296.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
MMD2_k127_1245295_5	339860.Msp_1556	4.915e-07	61.0	COG1522@1|root,arCOG01580@2157|Archaea,2XZQD@28890|Euryarchaeota,23PPJ@183925|Methanobacteria	183925|Methanobacteria	K	helix_turn_helix ASNC type	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_1245295_4	1365176.N186_00945	2.726e-07	62.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_1245295_6	1336241.JAEB01000001_gene25	6.337e-06	57.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,24I1I@186801|Clostridia,25WEA@186806|Eubacteriaceae	186801|Clostridia	K	Cytoplasmic, score 8.87	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_1245295_0	1042877.GQS_03265	4.204e-115	387.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,242S6@183968|Thermococci	183968|Thermococci	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
MMD2_k127_1245295_2	70601.3257428	3.115e-54	199.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,242TB@183968|Thermococci	183968|Thermococci	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMD2_k127_1245295_3	386456.JQKN01000001_gene1718	3.039e-21	98.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD2_k127_1289406_4	1096756.ATKN01000001_gene2379	9.231e-68	250.0	COG0433@1|root,COG0433@2|Bacteria,2GM12@201174|Actinobacteria,1W7YQ@1268|Micrococcaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
MMD2_k127_1289406_0	639282.DEFDS_0805	6.996e-129	432.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GENW@200930|Deferribacteres	200930|Deferribacteres	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
MMD2_k127_1289406_2	698757.Pogu_0973	8.035e-95	318.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMD2_k127_1289406_1	523850.TON_1069	4.132e-100	354.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
MMD2_k127_1289406_3	444158.MmarC6_0629	7.837e-70	253.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,23Q03@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
MMD2_k127_1353222_0	1034347.CAHJ01000010_gene2119	0.0004281	55.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,1ZCYC@1386|Bacillus	91061|Bacilli	T	phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
MMD2_k127_1379960_2	399741.Spro_4681	9.668e-06	53.0	COG1522@1|root,COG1522@2|Bacteria,1RFFU@1224|Proteobacteria,1T0WU@1236|Gammaproteobacteria,404ZA@613|Serratia	1236|Gammaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMD2_k127_1379960_0	1041930.Mtc_0139	1.913e-17	93.0	arCOG04609@1|root,arCOG04609@2157|Archaea,2XVS1@28890|Euryarchaeota,2N9XU@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
MMD2_k127_1379960_1	1457250.BBMO01000003_gene3224	3.319e-13	74.0	COG1591@1|root,arCOG00919@2157|Archaea,2XTHF@28890|Euryarchaeota,23TR3@183963|Halobacteria	183963|Halobacteria	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	hjc	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
MMD2_k127_1394647_1	246969.TAM4_632	2.925e-37	142.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,24415@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMD2_k127_1394647_3	1220534.B655_1460	8.34e-34	138.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,23NY2@183925|Methanobacteria	183925|Methanobacteria	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
MMD2_k127_1394647_0	351160.RCIX756	1.085e-46	187.0	COG2339@1|root,arCOG02985@2157|Archaea,2Y73S@28890|Euryarchaeota,2NB99@224756|Methanomicrobia	224756|Methanomicrobia	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
MMD2_k127_1394647_5	1191523.MROS_2026	2.758e-11	76.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N,Response_reg,SpoIIE
MMD2_k127_1394647_4	880526.KE386488_gene917	1.896e-15	90.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria,4NGSQ@976|Bacteroidetes,2FM60@200643|Bacteroidia,22U03@171550|Rikenellaceae	976|Bacteroidetes	GKT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppsA	-	-	-	-	-	-	-	-	-	-	-	PPDK_N,Response_reg
MMD2_k127_1394647_2	558152.IQ37_07155	4.098e-36	141.0	COG0537@1|root,COG0537@2|Bacteria,4NXJE@976|Bacteroidetes	976|Bacteroidetes	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMD2_k127_1550909_0	1459636.NTE_02193	7.28e-12	66.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
MMD2_k127_1598971_2	1045858.Bint_0214	0.0002385	49.0	COG0457@1|root,COG0457@2|Bacteria	1045858.Bint_0214|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1598971_0	237368.SCABRO_00519	3.356e-62	223.0	COG0284@1|root,COG0284@2|Bacteria,2IXSF@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
MMD2_k127_1598971_1	1229909.NSED_06605	3.046e-35	143.0	COG1651@1|root,arCOG02868@2157|Archaea	2157|Archaea	O	COG1651 Protein-disulfide isomerase	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans,Thioredoxin_4
MMD2_k127_1600234_7	1293047.CBMA010000008_gene304	6.172e-23	114.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota,240TC@183963|Halobacteria	183963|Halobacteria	C	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
MMD2_k127_1600234_4	573063.Metin_1443	2.064e-45	169.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23QV5@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMD2_k127_1600234_6	485913.Krac_9259	2.836e-24	111.0	COG1018@1|root,COG1018@2|Bacteria,2G7Q7@200795|Chloroflexi	200795|Chloroflexi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
MMD2_k127_1600234_2	436308.Nmar_1769	2.157e-86	301.0	COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
MMD2_k127_1600234_1	1173029.JH980292_gene1430	5.257e-90	307.0	COG1304@1|root,COG1304@2|Bacteria,1G2KC@1117|Cyanobacteria,1H8I2@1150|Oscillatoriales	1117|Cyanobacteria	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
MMD2_k127_1600234_9	1122207.MUS1_13990	1.858e-11	76.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1XI1F@135619|Oceanospirillales	135619|Oceanospirillales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
MMD2_k127_1600234_5	565033.GACE_1751	1.141e-28	121.0	COG1522@1|root,arCOG01580@2157|Archaea,2XWJA@28890|Euryarchaeota,2467I@183980|Archaeoglobi	183980|Archaeoglobi	K	AsnC family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_1600234_0	1499967.BAYZ01000119_gene3222	4.751e-206	650.0	COG0174@1|root,COG0174@2|Bacteria,2NNY0@2323|unclassified Bacteria	2|Bacteria	E	glutamine synthetase	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMD2_k127_1600234_8	1306947.ARQD01000001_gene806	4.506e-15	84.0	28W2D@1|root,2ZI3B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1600234_3	391625.PPSIR1_07807	4.292e-50	190.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMD2_k127_1612411_0	631454.N177_0106	1.281e-34	137.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,1JNEV@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMD2_k127_1612411_2	673860.AciM339_0977	2.5e-24	105.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,3F2QH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMD2_k127_1612411_1	272557.APE_2177.1	4.848e-29	125.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMD2_k127_1668633_7	572478.Vdis_0797	1.048e-05	55.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMD2_k127_1668633_5	247634.GPB2148_386	2.221e-12	76.0	COG1378@1|root,COG1378@2|Bacteria,1PZ3N@1224|Proteobacteria,1RS6X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMD2_k127_1668633_3	1463901.JOIY01000008_gene3007	4.254e-23	110.0	COG0172@1|root,COG0172@2|Bacteria	2|Bacteria	J	seryl-tRNA aminoacylation	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2b
MMD2_k127_1668633_9	1206732.BAGD01000036_gene1130	8.969e-05	51.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4G0ZM@85025|Nocardiaceae	201174|Actinobacteria	K	FR47-like protein	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMD2_k127_1668633_4	589924.Ferp_0852	2.091e-18	93.0	COG2129@1|root,arCOG01145@2157|Archaea,2XXXF@28890|Euryarchaeota,2469Z@183980|Archaeoglobi	183980|Archaeoglobi	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos_2
MMD2_k127_1668633_1	399549.Msed_1722	1.942e-53	198.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMD2_k127_1668633_2	224325.AF_1443	5.91e-29	124.0	COG0467@1|root,arCOG01171@2157|Archaea,2XUWH@28890|Euryarchaeota,245RB@183980|Archaeoglobi	183980|Archaeoglobi	T	PFAM Circadian clock protein KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD2_k127_1668633_10	883069.HMPREF9238_00056	0.0001034	52.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4D3Y1@85005|Actinomycetales	201174|Actinobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMD2_k127_1668633_0	272557.APE_0662.1	1.6e-79	284.0	COG0124@1|root,arCOG00404@2157|Archaea,2XPY6@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMD2_k127_1668633_8	1219045.BV98_003543	3.926e-05	48.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,2K1P3@204457|Sphingomonadales	204457|Sphingomonadales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
MMD2_k127_1696179_4	1433126.BN938_1164	3.659e-21	101.0	COG0527@1|root,COG0527@2|Bacteria,4NJDY@976|Bacteroidetes,2FSWX@200643|Bacteroidia,22U2J@171550|Rikenellaceae	976|Bacteroidetes	E	aspartate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1696179_7	1117647.M5M_12030	5.354e-06	55.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,1S133@1236|Gammaproteobacteria,1JAAK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
MMD2_k127_1696179_5	626418.bglu_2g22760	4.103e-07	60.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,1K3XS@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
MMD2_k127_1696179_2	660470.Theba_0013	8.869e-120	393.0	COG0057@1|root,COG0057@2|Bacteria,2GCBQ@200918|Thermotogae	200918|Thermotogae	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
MMD2_k127_1696179_6	161156.JQKW01000010_gene378	6.444e-07	63.0	COG2214@1|root,COG2214@2|Bacteria,2GHPD@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1696179_9	593750.Metfor_2447	0.0008169	49.0	COG0785@1|root,arCOG02400@2157|Archaea	2157|Archaea	O	cytochrome c biogenesis protein, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
MMD2_k127_1696179_3	579137.Metvu_1666	9.736e-68	243.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,23Q56@183939|Methanococci	183939|Methanococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMD2_k127_1696179_8	1463936.JOJI01000140_gene13	6.979e-05	53.0	COG0500@1|root,COG2226@2|Bacteria,2II3C@201174|Actinobacteria	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMD2_k127_1696179_0	1041930.Mtc_2238	7.352e-282	888.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,2N95T@224756|Methanomicrobia	224756|Methanomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMD2_k127_1696179_1	649747.HMPREF0083_05957	5.667e-243	766.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H9Y6@91061|Bacilli,26R74@186822|Paenibacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMD2_k127_1852649_1	579137.Metvu_0869	1.994e-80	278.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23Q49@183939|Methanococci	183939|Methanococci	J	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMD2_k127_1852649_0	224325.AF_1149	1.593e-170	566.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,245QX@183980|Archaeoglobi	183980|Archaeoglobi	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMD2_k127_1868922_7	1205683.CAKR01000025_gene3698	0.0008801	51.0	COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,1RPMS@1236|Gammaproteobacteria,41HAQ@629|Yersinia	1236|Gammaproteobacteria	M	Capsule polysaccharide biosynthesis protein	kpsC	-	-	ko:K07266	-	-	-	-	ko00000	-	-	-	Capsule_synth
MMD2_k127_1868922_5	1047013.AQSP01000144_gene788	7.306e-14	84.0	COG3562@1|root,COG3562@2|Bacteria	2|Bacteria	M	capsule polysaccharide	-	-	-	ko:K07265	-	-	-	-	ko00000	-	-	-	Capsule_synth
MMD2_k127_1868922_6	1129374.AJE_13596	5.922e-08	64.0	COG0679@1|root,COG0679@2|Bacteria,1PHSS@1224|Proteobacteria,1RRY0@1236|Gammaproteobacteria,46762@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
MMD2_k127_1868922_0	247490.KSU1_C1707	3.28e-95	323.0	COG0451@1|root,COG0451@2|Bacteria,2J0GN@203682|Planctomycetes	203682|Planctomycetes	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMD2_k127_1868922_2	1120746.CCNL01000014_gene2167	3.292e-62	229.0	COG1208@1|root,COG1208@2|Bacteria,2NQH0@2323|unclassified Bacteria	2|Bacteria	JM	Nucleotidyl transferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
MMD2_k127_1868922_3	269797.Mbar_A0369	6.964e-53	201.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVUJ@28890|Euryarchaeota,2N97I@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD2_k127_1868922_1	273075.Ta0343	5.553e-89	302.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.20	ko:K01784,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
MMD2_k127_1868922_4	1158338.JNLJ01000001_gene864	4.464e-22	111.0	COG2244@1|root,COG2244@2|Bacteria,2G4RS@200783|Aquificae	200783|Aquificae	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE,Polysacc_synt,Polysacc_synt_C
MMD2_k127_1992920_0	444158.MmarC6_1153	2.391e-08	66.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23QU7@183939|Methanococci	183939|Methanococci	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2088951_11	1333523.L593_07570	0.0009234	48.0	COG3815@1|root,arCOG03949@2157|Archaea,2XZ2C@28890|Euryarchaeota,23X0I@183963|Halobacteria	183963|Halobacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
MMD2_k127_2088951_8	243232.MJ_1443	3.281e-11	69.0	COG4818@1|root,arCOG04344@2157|Archaea,2XZ6C@28890|Euryarchaeota,23R98@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
MMD2_k127_2088951_1	342949.PNA2_1256	2.587e-135	445.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,243CK@183968|Thermococci	183968|Thermococci	J	Cysteinyl-tRNA synthetase	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMD2_k127_2088951_9	351160.LRC485	2.306e-10	66.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,2NA1Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
MMD2_k127_2088951_5	1121382.JQKG01000001_gene2462	1.396e-20	100.0	COG1215@1|root,COG1215@2|Bacteria,1WIAI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMD2_k127_2088951_4	304371.MCP_0210	1.378e-49	185.0	COG0463@1|root,arCOG01386@2157|Archaea,2Y7ST@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMD2_k127_2088951_3	289376.THEYE_A0805	2.914e-59	213.0	COG0299@1|root,COG0299@2|Bacteria,3J0MC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
MMD2_k127_2088951_10	368407.Memar_2385	1.225e-05	51.0	arCOG05132@1|root,arCOG05132@2157|Archaea	2157|Archaea	S	SigmaK-factor processing regulatory protein BofA	-	-	-	-	-	-	-	-	-	-	-	-	BofA
MMD2_k127_2088951_6	266117.Rxyl_0044	4.445e-18	96.0	COG2333@1|root,COG2333@2|Bacteria,2I4B4@201174|Actinobacteria	201174|Actinobacteria	S	competence protein COMEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Lactamase_B
MMD2_k127_2088951_2	1131266.ARWQ01000001_gene1294	7.601e-115	388.0	COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota	651137|Thaumarchaeota	J	synthetase (class II)	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMD2_k127_2088951_0	529709.PYCH_13670	4.416e-198	649.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,243PB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMD2_k127_2088951_7	264732.Moth_0508	1.393e-13	75.0	COG2140@1|root,COG2140@2|Bacteria,1W79J@1239|Firmicutes,25K1K@186801|Clostridia,42IUM@68295|Thermoanaerobacterales	186801|Clostridia	G	Glucose-6-phosphate isomerase (GPI)	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
MMD2_k127_219377_5	999630.TUZN_1185	3.156e-09	66.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMD2_k127_219377_2	309799.DICTH_1320	1.183e-45	170.0	COG2236@1|root,COG2236@2|Bacteria	2|Bacteria	F	xanthine phosphoribosyltransferase activity	gpt	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
MMD2_k127_219377_0	224719.Abm4_1550	4.238e-199	638.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
MMD2_k127_219377_1	269797.Mbar_A0194	3.026e-59	212.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMD2_k127_219377_3	351160.RRC331	1.389e-12	77.0	COG1047@1|root,arCOG00981@2157|Archaea,2XXFW@28890|Euryarchaeota	28890|Euryarchaeota	O	Peptidyl-prolyl cis-trans	mtfK1	-	5.2.1.8	ko:K01802,ko:K03768,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMD2_k127_219377_4	96561.Dole_1096	5.7e-10	72.0	COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,42TI1@68525|delta/epsilon subdivisions,2WQ9N@28221|Deltaproteobacteria,2MKQG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4
MMD2_k127_2284702_1	1227497.C491_04255	4.674e-10	70.0	COG2340@1|root,arCOG03962@2157|Archaea,2XT4K@28890|Euryarchaeota,23TF2@183963|Halobacteria	183963|Halobacteria	S	protein with SCP PR1 domains	-	-	-	-	-	-	-	-	-	-	-	-	CAP
MMD2_k127_2284702_0	243232.MJ_0542	5.478e-98	331.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,23Q5F@183939|Methanococci	183939|Methanococci	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMD2_k127_2285691_1	406327.Mevan_1425	3.346e-41	159.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,23Q1F@183939|Methanococci	183939|Methanococci	K	RNA binding S1 domain protein	-	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
MMD2_k127_2285691_2	1094980.Mpsy_0972	1.256e-07	55.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
MMD2_k127_2285691_0	186497.PF1497	5.541e-97	331.0	COG0436@1|root,arCOG01131@2157|Archaea,2XVXM@28890|Euryarchaeota,243JD@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMD2_k127_2285691_3	186497.PF0994	6.414e-05	56.0	COG4962@1|root,arCOG03157@1|root,arCOG01819@2157|Archaea,arCOG03157@2157|Archaea,2Y8F5@28890|Euryarchaeota,242XB@183968|Thermococci	183968|Thermococci	U	type II secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Intein_splicing,LAGLIDADG_3,T2SSE
MMD2_k127_232334_1	386456.JQKN01000001_gene2345	1.449e-111	375.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,23NMW@183925|Methanobacteria	183925|Methanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMD2_k127_232334_0	573063.Metin_0816	9.498e-136	450.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,23QDW@183939|Methanococci	183939|Methanococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
MMD2_k127_2357636_3	368407.Memar_2129	4.792e-06	59.0	COG1413@1|root,arCOG06940@1|root,arCOG02966@2157|Archaea,arCOG06940@2157|Archaea,2XSWS@28890|Euryarchaeota	28890|Euryarchaeota	C	PBS lyase	cpcE2	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS
MMD2_k127_2357636_2	1121899.Q764_04400	6.46e-51	185.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,1I1Y2@117743|Flavobacteriia,2P02D@237|Flavobacterium	976|Bacteroidetes	O	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
MMD2_k127_2357636_0	4555.Si000735m	4.299e-262	821.0	COG0045@1|root,KOG1254@2759|Eukaryota,37M9Y@33090|Viridiplantae,3G8F2@35493|Streptophyta,3KPH8@4447|Liliopsida,3I89D@38820|Poales	35493|Streptophyta	C	ATP-citrate synthase	ACLB-1	GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	Citrate_synt,CoA_binding,Ligase_CoA
MMD2_k127_2357636_1	248742.XP_005649153.1	8.714e-98	325.0	COG0045@1|root,KOG1254@2759|Eukaryota,37IP2@33090|Viridiplantae,34JNA@3041|Chlorophyta	3041|Chlorophyta	C	ATP citrate lyase citrate-binding	-	-	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	ATP-grasp_2,Citrate_bind
MMD2_k127_2363149_4	369723.Strop_3684	1.21e-21	106.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4D9A2@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
MMD2_k127_2363149_1	593750.Metfor_0715	1.949e-50	195.0	COG0475@1|root,arCOG01953@2157|Archaea,2XV77@28890|Euryarchaeota,2NATR@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMD2_k127_2363149_0	224719.Abm4_1550	5.118e-83	292.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
MMD2_k127_2363149_2	390989.JOEG01000001_gene4973	4.486e-22	99.0	COG2151@1|root,COG2151@2|Bacteria,2IKUH@201174|Actinobacteria	201174|Actinobacteria	J	metal-sulfur cluster biosynthetic enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMD2_k127_2363149_6	1120998.AUFC01000021_gene952	5.596e-07	56.0	COG4747@1|root,COG4747@2|Bacteria,1V4AA@1239|Firmicutes,25DMC@186801|Clostridia	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2363149_5	593117.TGAM_1285	6.496e-18	89.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,2441K@183968|Thermococci	183968|Thermococci	V	Fcf1	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1
MMD2_k127_2363149_3	1259795.ARJK01000002_gene622	5.77e-22	106.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,42F13@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMD2_k127_2374878_0	529709.PYCH_02180	6.504e-99	335.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMD2_k127_2374878_2	1094980.Mpsy_2070	7.818e-05	50.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y0G2@28890|Euryarchaeota,2NA2F@224756|Methanomicrobia	224756|Methanomicrobia	L	metal ion binding	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_4
MMD2_k127_2374878_1	1459636.NTE_02514	5.206e-21	99.0	COG0517@1|root,arCOG00606@2157|Archaea,41T8N@651137|Thaumarchaeota	651137|Thaumarchaeota	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD2_k127_2375596_3	573063.Metin_0397	1.173e-10	66.0	COG5427@1|root,arCOG00563@2157|Archaea,2Y2Q0@28890|Euryarchaeota,23RIP@183939|Methanococci	183939|Methanococci	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2375596_0	224325.AF_0361	8.228e-89	304.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,245TJ@183980|Archaeoglobi	183980|Archaeoglobi	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMD2_k127_2375596_1	1131266.ARWQ01000001_gene1200	1.475e-87	302.0	COG0731@1|root,arCOG04174@2157|Archaea,41SBS@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMD2_k127_2375596_2	386456.JQKN01000007_gene3245	9.807e-52	200.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,23NT6@183925|Methanobacteria	183925|Methanobacteria	U	secretion system protein	gspE	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMD2_k127_2375596_5	69014.TK1851	5.738e-10	72.0	COG2064@1|root,arCOG01811@2157|Archaea,2Y68E@28890|Euryarchaeota,243AB@183968|Thermococci	183968|Thermococci	N	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
MMD2_k127_2375596_6	394503.Ccel_3348	2.242e-06	55.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,36JV0@31979|Clostridiaceae	186801|Clostridia	I	Membrane-associated phospholipid phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
MMD2_k127_2375596_4	224324.aq_1542	1.51e-10	70.0	COG0170@1|root,COG0170@2|Bacteria,2G5BD@200783|Aquificae	200783|Aquificae	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2375596_7	593117.TGAM_0482	2.119e-05	49.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,243DT@183968|Thermococci	183968|Thermococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMD2_k127_2382587_1	760192.Halhy_3494	4.127e-26	116.0	COG1451@1|root,COG1451@2|Bacteria,4NIY4@976|Bacteroidetes,1IUYI@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
MMD2_k127_2382587_2	331678.Cphamn1_2131	3.686e-14	78.0	COG1941@1|root,COG1941@2|Bacteria,1FDE2@1090|Chlorobi	1090|Chlorobi	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
MMD2_k127_2382587_0	237368.SCABRO_02487	6.628e-74	264.0	COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes	203682|Planctomycetes	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
MMD2_k127_2382587_3	1227457.C451_15853	1.387e-07	57.0	COG0095@1|root,arCOG03837@2157|Archaea,2Y0Z6@28890|Euryarchaeota,23Y8E@183963|Halobacteria	183963|Halobacteria	H	COG0095 Lipoate-protein ligase A	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2399313_2	192952.MM_1571	1.58e-19	99.0	COG2968@1|root,arCOG04715@2157|Archaea,2XZAZ@28890|Euryarchaeota,2N9TF@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
MMD2_k127_2399313_0	391625.PPSIR1_07842	2.219e-76	273.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMD2_k127_2399313_3	1169161.KB897716_gene5917	7.526e-06	59.0	COG1053@1|root,COG1413@1|root,COG1053@2|Bacteria,COG1413@2|Bacteria,2GPN8@201174|Actinobacteria	201174|Actinobacteria	C	fumarate reductase	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Cohesin_HEAT,FAD_binding_2,HEAT_2,Succ_DH_flav_C
MMD2_k127_2399313_1	573063.Metin_0372	4.09e-40	155.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,23Q2G@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMD2_k127_2406693_2	572546.Arcpr_0476	5.005e-58	217.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,245V2@183980|Archaeoglobi	183980|Archaeoglobi	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMD2_k127_2406693_1	1123508.JH636443_gene4577	1.258e-58	218.0	COG0657@1|root,COG0657@2|Bacteria,2IXCK@203682|Planctomycetes	203682|Planctomycetes	I	COG0657 Esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,EF-hand_5,Peptidase_S9
MMD2_k127_2406693_4	324602.Caur_0488	2.052e-10	74.0	COG0115@1|root,COG0115@2|Bacteria,2G6AX@200795|Chloroflexi,3753Z@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMD2_k127_2406693_7	368408.Tpen_1604	0.000747	50.0	COG1475@1|root,arCOG01875@2157|Archaea,2XSRF@28889|Crenarchaeota	28889|Crenarchaeota	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
MMD2_k127_2406693_6	373903.Hore_04230	8.131e-05	55.0	COG1470@1|root,COG1470@2|Bacteria,1TVG5@1239|Firmicutes,25PWD@186801|Clostridia,3WBRE@53433|Halanaerobiales	186801|Clostridia	G	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
MMD2_k127_2406693_0	444158.MmarC6_0530	2.173e-142	481.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,23QQF@183939|Methanococci	183939|Methanococci	L	SMART DNA-directed DNA polymerase B	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing,LAGLIDADG_3
MMD2_k127_2406693_3	572546.Arcpr_0709	1.239e-48	186.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,245ZB@183980|Archaeoglobi	183980|Archaeoglobi	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
MMD2_k127_2411616_0	387631.Asulf_00818	2.628e-240	774.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2462I@183980|Archaeoglobi	183980|Archaeoglobi	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD2_k127_2411616_9	1229909.NSED_04755	1.076e-21	104.0	COG0467@1|root,arCOG01171@2157|Archaea,41TA0@651137|Thaumarchaeota	651137|Thaumarchaeota	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
MMD2_k127_2411616_11	1121017.AUFG01000001_gene2995	5.447e-17	92.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria,4FEN8@85021|Intrasporangiaceae	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMD2_k127_2411616_10	511051.CSE_07000	3.233e-20	99.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMD2_k127_2411616_6	391623.TERMP_01295	2.895e-52	203.0	COG0467@1|root,arCOG01174@2157|Archaea,2XV95@28890|Euryarchaeota,243WZ@183968|Thermococci	183968|Thermococci	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
MMD2_k127_2411616_2	868131.MSWAN_0085	1.059e-89	310.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,23NU8@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent	dadD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMD2_k127_2411616_4	351160.RRC285	1.236e-83	290.0	COG0598@1|root,arCOG02265@2157|Archaea	2157|Archaea	P	Mediates influx of magnesium ions	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMD2_k127_2411616_7	1261545.MBE-HAL_2033	9.438e-46	173.0	COG5658@1|root,arCOG04484@2157|Archaea,2XVWE@28890|Euryarchaeota,23UN8@183963|Halobacteria	183963|Halobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
MMD2_k127_2411616_3	243232.MJ_0641	5.456e-84	292.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,23QGF@183939|Methanococci	183939|Methanococci	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMD2_k127_2411616_1	523845.AQXV01000042_gene311	8.675e-174	567.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,23QA8@183939|Methanococci	183939|Methanococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,Topoisom_bac,Toprim,zf-C4_Topoisom
MMD2_k127_2411616_13	1365176.N186_00695	6.262e-12	66.0	COG3350@1|root,arCOG02763@1|root,arCOG02763@2157|Archaea,arCOG04507@2157|Archaea,2XSRT@28889|Crenarchaeota	28889|Crenarchaeota	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMD2_k127_2411616_14	591019.Shell_0641	3.126e-10	72.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_2411616_12	936136.ARRT01000006_gene2897	1.313e-14	85.0	COG1522@1|root,COG1522@2|Bacteria,1RAS5@1224|Proteobacteria,2VG6P@28211|Alphaproteobacteria,4BB0I@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_2411616_8	1094980.Mpsy_1357	1.287e-45	181.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NAGX@224756|Methanomicrobia	224756|Methanomicrobia	P	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD2_k127_2411616_5	579137.Metvu_1136	2.989e-62	229.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,23QAJ@183939|Methanococci	183939|Methanococci	V	MacB-like periplasmic core domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD2_k127_2411616_15	456442.Mboo_2326	6.405e-06	56.0	COG1361@1|root,arCOG02079@2157|Archaea	2157|Archaea	M	COG1361 S-layer domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,NPCBM_assoc
MMD2_k127_2437333_0	243232.MJ_1555	9.044e-102	344.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,23QJI@183939|Methanococci	183939|Methanococci	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMD2_k127_2437333_1	1132509.C447_07078	9.767e-12	77.0	arCOG02498@1|root,arCOG02498@2157|Archaea,2Y82I@28890|Euryarchaeota,2413G@183963|Halobacteria	183963|Halobacteria	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
MMD2_k127_245491_0	1122622.ATWJ01000001_gene2541	3.352e-56	211.0	COG0438@1|root,COG0438@2|Bacteria,2GIZG@201174|Actinobacteria,4FICH@85021|Intrasporangiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	sqdX	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMD2_k127_245491_1	1220534.B655_0255	3.987e-18	94.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,23P4X@183925|Methanobacteria	183925|Methanobacteria	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
MMD2_k127_245491_2	1220535.IMCC14465_15910	4.269e-14	81.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria,4BQB5@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	NUDIX domain	mutT	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
MMD2_k127_2486652_0	1250232.JQNJ01000001_gene33	4.226e-51	192.0	COG1327@1|root,COG1327@2|Bacteria,4NHXI@976|Bacteroidetes,1HYJ8@117743|Flavobacteriia	976|Bacteroidetes	K	Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	ATP-cone,Mrr_cat
MMD2_k127_2494787_0	204669.Acid345_1942	1.062e-119	394.0	COG1899@1|root,COG1899@2|Bacteria,3Y5EW@57723|Acidobacteria,2JJNA@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMD2_k127_2494787_1	573064.Mefer_1096	1.495e-16	81.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,23Q7D@183939|Methanococci	183939|Methanococci	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMD2_k127_2497114_3	797303.Natpe_3584	2.482e-08	64.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XWNK@28890|Euryarchaeota,23V88@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMD2_k127_2497114_2	765177.Desmu_1285	2.301e-08	65.0	COG0498@1|root,arCOG01434@2157|Archaea,2XQ0W@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMD2_k127_2497114_0	195522.BD01_1821	7.914e-115	383.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
MMD2_k127_2497114_1	1463920.JOGB01000003_gene2581	2.558e-10	73.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria	201174|Actinobacteria	O	belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMD2_k127_2549705_0	1227499.C493_12689	1.051e-104	346.0	COG0022@1|root,arCOG01052@2157|Archaea,2XT3K@28890|Euryarchaeota,23SKR@183963|Halobacteria	183963|Halobacteria	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	oxdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMD2_k127_2549705_1	1321778.HMPREF1982_00055	7.488e-101	342.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,26A0H@186813|unclassified Clostridiales	186801|Clostridia	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMD2_k127_2549705_3	349124.Hhal_0116	6.72e-88	300.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMD2_k127_2549705_2	1123354.AUDR01000018_gene1126	5.828e-89	308.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KRXA@119069|Hydrogenophilales	119069|Hydrogenophilales	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
MMD2_k127_2549705_4	523845.AQXV01000036_gene475	2.617e-33	140.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,23QFU@183939|Methanococci	183939|Methanococci	J	PFAM elongation factor Tu, domain 2 protein	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
MMD2_k127_2549705_5	309807.SRU_1720	3.576e-15	77.0	COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1FK37@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMD2_k127_2587377_2	935948.KE386493_gene2429	1.198e-37	147.0	COG0426@1|root,COG0426@2|Bacteria,1V80E@1239|Firmicutes,24EX9@186801|Clostridia	186801|Clostridia	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD2_k127_2587377_0	195522.BD01_1056	1.215e-109	370.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
MMD2_k127_2587377_1	374847.Kcr_0115	4.882e-48	179.0	COG1042@1|root,arCOG01338@2157|Archaea	2157|Archaea	C	Acyl-CoA synthetase (NDP forming)	acdB	-	6.2.1.13	ko:K01905,ko:K18594,ko:K22224	ko00010,ko00620,ko00640,ko00720,ko01100,ko01120,map00010,map00620,map00640,map00720,map01100,map01120	-	R00229,R00920,R03157	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
MMD2_k127_2587377_3	868131.MSWAN_0765	2.089e-14	76.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
MMD2_k127_2587377_4	1128421.JAGA01000002_gene1275	2.272e-14	77.0	COG2096@1|root,COG2096@2|Bacteria,2NPP8@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MMAB	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
MMD2_k127_2595215_2	339860.Msp_1167	7.973e-25	107.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,23P0U@183925|Methanobacteria	183925|Methanobacteria	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
MMD2_k127_2595215_0	246194.CHY_1057	1.457e-86	295.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,42JFW@68295|Thermoanaerobacterales	186801|Clostridia	M	RmlD substrate binding domain	-	-	4.1.1.35,5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274,ko:K08678	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R01384,R02984,R05176	RC00289,RC00508,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
MMD2_k127_2595215_1	351160.RCIX2409	4.319e-56	205.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMD2_k127_2603918_1	572546.Arcpr_0822	4.606e-23	111.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,245S1@183980|Archaeoglobi	183980|Archaeoglobi	L	Nucleic acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	S1,tRNA_anti-codon
MMD2_k127_2603918_2	130081.XP_005707036.1	8.145e-12	78.0	COG0436@1|root,KOG0259@2759|Eukaryota	2759|Eukaryota	E	L-tyrosine aminotransferase activity	TAT	GO:0001101,GO:0001558,GO:0001560,GO:0002119,GO:0002164,GO:0003674,GO:0003824,GO:0004121,GO:0004838,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005829,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006766,GO:0006775,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007275,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009110,GO:0009605,GO:0009611,GO:0009628,GO:0009636,GO:0009651,GO:0009683,GO:0009684,GO:0009719,GO:0009725,GO:0009737,GO:0009753,GO:0009791,GO:0009850,GO:0009851,GO:0009987,GO:0009991,GO:0010033,GO:0010188,GO:0010189,GO:0010817,GO:0016020,GO:0016053,GO:0016054,GO:0016143,GO:0016144,GO:0016740,GO:0016769,GO:0016829,GO:0016846,GO:0018130,GO:0019438,GO:0019439,GO:0019748,GO:0019752,GO:0019757,GO:0019758,GO:0019760,GO:0019761,GO:0022611,GO:0022622,GO:0031668,GO:0032501,GO:0032502,GO:0032787,GO:0033855,GO:0033993,GO:0034641,GO:0034754,GO:0040008,GO:0040024,GO:0042221,GO:0042360,GO:0042362,GO:0042430,GO:0042435,GO:0042445,GO:0042446,GO:0042538,GO:0043053,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046394,GO:0046395,GO:0046483,GO:0048046,GO:0048364,GO:0048731,GO:0048830,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051716,GO:0055115,GO:0065007,GO:0065008,GO:0070547,GO:0071496,GO:0071704,GO:0072330,GO:0080108,GO:0097305,GO:0099402,GO:1901135,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901615,GO:1901617,GO:1901657,GO:1901659,GO:1901700	2.6.1.5,2.6.1.80,4.4.1.35	ko:K00815,ko:K11819,ko:K14271,ko:K21623	ko00130,ko00270,ko00350,ko00360,ko00380,ko00400,ko00401,ko00950,ko00960,ko00966,ko01100,ko01110,ko01130,ko01210,ko01230,map00130,map00270,map00350,map00360,map00380,map00400,map00401,map00950,map00960,map00966,map01100,map01110,map01130,map01210,map01230	M00025,M00034,M00370	R00694,R00734,R02408,R07396,R08170,R08654,R08660,R08667,R08686	RC00006,RC00488,RC00710,RC02265,RC02303	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMD2_k127_2603918_0	357808.RoseRS_1980	1.278e-37	146.0	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi,3777D@32061|Chloroflexia	32061|Chloroflexia	S	PFAM cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
MMD2_k127_2610657_2	1081644.IMCC13023_02200	6.369e-10	67.0	COG2020@1|root,COG2020@2|Bacteria,2HTD4@201174|Actinobacteria,4FT14@85023|Microbacteriaceae	201174|Actinobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
MMD2_k127_2610657_1	1283300.ATXB01000001_gene2418	4.719e-23	101.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1XFSQ@135618|Methylococcales	135618|Methylococcales	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMD2_k127_2610657_0	1157490.EL26_07290	2.918e-45	175.0	COG1230@1|root,COG1230@2|Bacteria,1TR92@1239|Firmicutes,4HBCQ@91061|Bacilli,278VE@186823|Alicyclobacillaceae	91061|Bacilli	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux,ZT_dimer
MMD2_k127_2635184_1	1313265.JNIE01000008_gene97	9.825e-149	490.0	COG1793@1|root,COG1793@2|Bacteria	2|Bacteria	L	dna ligase	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMD2_k127_2635184_2	404380.Gbem_2725	4.295e-110	372.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,43RYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
MMD2_k127_2635184_3	298655.KI912266_gene5219	2.234e-09	66.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4ESUV@85013|Frankiales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
MMD2_k127_2635184_0	1229909.NSED_03345	3.402e-160	511.0	COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
MMD2_k127_273009_0	673860.AciM339_0086	1.844e-214	687.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,3F2Z5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
MMD2_k127_273009_14	1229909.NSED_02545	2.808e-06	57.0	COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMD2_k127_273009_1	1459636.NTE_02266	4.03e-129	433.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMD2_k127_273009_7	1121324.CLIT_11c02940	2.748e-28	124.0	COG3324@1|root,COG3324@2|Bacteria,1U9T0@1239|Firmicutes,256I7@186801|Clostridia	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
MMD2_k127_273009_2	693661.Arcve_0375	1.602e-78	272.0	COG2248@1|root,arCOG00969@2157|Archaea,2XW12@28890|Euryarchaeota,246PQ@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0282 family	-	-	-	ko:K07022	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
MMD2_k127_273009_8	596152.DesU5LDRAFT_2681	1.459e-22	99.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_273009_6	330779.Saci_1520	7.447e-30	123.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMD2_k127_273009_9	604354.TSIB_0420	5.052e-18	86.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,244JE@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMD2_k127_273009_11	1229909.NSED_00960	1.508e-16	81.0	COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMD2_k127_273009_4	1268240.ATFI01000009_gene1717	3.256e-45	168.0	COG0105@1|root,COG0105@2|Bacteria,4NM5B@976|Bacteroidetes,2FNRV@200643|Bacteroidia,4AN6V@815|Bacteroidaceae	976|Bacteroidetes	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMD2_k127_273009_5	1184267.A11Q_2181	3.544e-30	123.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2MU5K@213481|Bdellovibrionales,2WT56@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
MMD2_k127_273009_3	443254.Marpi_0829	3.364e-63	220.0	COG0017@1|root,COG0017@2|Bacteria,2GC59@200918|Thermotogae	200918|Thermotogae	J	class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMD2_k127_2750515_3	743721.Psesu_2255	2.095e-19	102.0	COG2199@1|root,COG3706@2|Bacteria,1RBNT@1224|Proteobacteria,1S3CV@1236|Gammaproteobacteria,1XCBY@135614|Xanthomonadales	135614|Xanthomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMD2_k127_2750515_1	1443125.Z962_03040	2.959e-47	183.0	COG1525@1|root,COG2333@1|root,COG1525@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,36DFY@31979|Clostridiaceae	186801|Clostridia	L	domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
MMD2_k127_2750515_4	224325.AF_1187	0.0002463	52.0	COG3582@1|root,arCOG03449@2157|Archaea,2Y7PT@28890|Euryarchaeota	28890|Euryarchaeota	S	AN1-like Zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
MMD2_k127_2750515_0	351160.RCIX770	1.732e-53	196.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,2N9G7@224756|Methanomicrobia	224756|Methanomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMD2_k127_2750515_2	348780.NP_0416A	2.526e-30	126.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23TW1@183963|Halobacteria	183963|Halobacteria	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMD2_k127_277099_0	453591.Igni_1092	1.138e-58	214.0	COG0648@1|root,arCOG01894@2157|Archaea,2XPUX@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMD2_k127_2788621_3	572546.Arcpr_1235	1.273e-26	114.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,246SU@183980|Archaeoglobi	183980|Archaeoglobi	G	PFAM Glucose-6-phosphate isomerase	-	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
MMD2_k127_2788621_2	224325.AF_2157	1.17e-34	139.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,246AE@183980|Archaeoglobi	183980|Archaeoglobi	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMD2_k127_2788621_1	444158.MmarC6_1145	4.464e-41	167.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,23QIH@183939|Methanococci	183939|Methanococci	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_2788621_0	565033.GACE_1941	1.672e-213	683.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245PD@183980|Archaeoglobi	183980|Archaeoglobi	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
MMD2_k127_291831_2	243232.MJ_0616	7.125e-20	91.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,23QSX@183939|Methanococci	183939|Methanococci	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMD2_k127_291831_4	158189.SpiBuddy_0458	1.777e-08	62.0	arCOG05193@1|root,2ZZSG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_291831_3	186497.PF1378	4.218e-11	69.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2445Q@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
MMD2_k127_291831_5	387631.Asulf_00132	0.0007604	49.0	COG2512@1|root,arCOG00377@2157|Archaea,2XY2E@28890|Euryarchaeota,246A4@183980|Archaeoglobi	183980|Archaeoglobi	K	Winged helix-turn-helix DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD2_k127_291831_1	663610.JQKO01000009_gene429	1.306e-102	352.0	COG1652@1|root,COG2608@1|root,COG2836@1|root,COG4633@1|root,COG1652@2|Bacteria,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1PJEP@1224|Proteobacteria,2U3C2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2,HMA,LysM
MMD2_k127_291831_0	350688.Clos_1066	2.632e-145	476.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMD2_k127_2934468_0	273057.SSO0283	2.444e-06	59.0	COG0433@1|root,arCOG00286@2157|Archaea,2XQKU@28889|Crenarchaeota	28889|Crenarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMD2_k127_2957098_3	269797.Mbar_A3223	2.397e-05	49.0	arCOG01059@1|root,arCOG01059@2157|Archaea,2Y0H1@28890|Euryarchaeota,2N9Y0@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2957098_1	593750.Metfor_2881	2.876e-33	128.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2957098_2	1041930.Mtc_1366	1.352e-28	119.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2N9XB@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMD2_k127_2957098_0	573063.Metin_0173	1.46e-139	454.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
MMD2_k127_2960879_1	694429.Pyrfu_0208	4.94e-39	151.0	COG1056@1|root,arCOG00972@2157|Archaea,2XQI1@28889|Crenarchaeota	28889|Crenarchaeota	F	nicotinamide-nucleotide adenylyltransferase	nadM	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMD2_k127_2960879_0	195522.BD01_0916	2.994e-77	289.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMD2_k127_2969071_7	215803.DB30_1928	4.354e-24	112.0	COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2YU4W@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
MMD2_k127_2969071_1	453591.Igni_0393	6.001e-167	537.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
MMD2_k127_2969071_9	1121930.AQXG01000002_gene2094	5.435e-07	63.0	COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes,1IPQW@117747|Sphingobacteriia	976|Bacteroidetes	V	PFAM ABC-2 type transporter	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD2_k127_2969071_10	1122605.KB893637_gene3147	6.075e-05	56.0	COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes,1IPQW@117747|Sphingobacteriia	976|Bacteroidetes	V	PFAM ABC-2 type transporter	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMD2_k127_2969071_5	479434.Sthe_0431	6.141e-64	231.0	COG1131@1|root,COG1131@2|Bacteria,2G68Y@200795|Chloroflexi	200795|Chloroflexi	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD2_k127_2969071_4	439481.Aboo_0039	2.361e-79	275.0	COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,3F2X1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Amino acid kinase family	cpkA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD2_k127_2969071_2	523850.TON_1432	2.722e-166	533.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMD2_k127_2969071_6	192952.MM_1628	1.203e-40	155.0	COG0717@1|root,arCOG04048@2157|Archaea,2XVHA@28890|Euryarchaeota,2NBIR@224756|Methanomicrobia	224756|Methanomicrobia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
MMD2_k127_2969071_0	192952.MM_0048	2.689e-185	591.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMD2_k127_2969071_3	269797.Mbar_A2386	3.765e-115	385.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2NBNP@224756|Methanomicrobia	224756|Methanomicrobia	E	Aminotransferase class-III	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMD2_k127_2969071_8	44251.PDUR_19175	3.966e-12	71.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,1VB6A@1239|Firmicutes,4HVDE@91061|Bacilli	91061|Bacilli	LV	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3065889_4	562970.Btus_1809	2.267e-40	153.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,4HIZT@91061|Bacilli,278IP@186823|Alicyclobacillaceae	91061|Bacilli	S	CoA binding domain	yneT	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
MMD2_k127_3065889_5	316274.Haur_0039	5.724e-30	125.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMD2_k127_3065889_2	399550.Smar_1138	1.598e-72	251.0	COG0013@1|root,arCOG01254@2157|Archaea,2XPWU@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Threonyl alanyl tRNA synthetase, SAD	-	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMD2_k127_3065889_3	419665.Maeo_0737	4.029e-55	201.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,23Q27@183939|Methanococci	183939|Methanococci	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
MMD2_k127_3065889_8	517417.Cpar_1838	1.224e-12	80.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMD2_k127_3065889_7	523850.TON_1911	1.181e-13	77.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2440N@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
MMD2_k127_3065889_9	573063.Metin_0198	1.379e-11	72.0	COG2314@1|root,COG3815@1|root,arCOG03293@2157|Archaea,arCOG03949@2157|Archaea,2XYU1@28890|Euryarchaeota,23RS2@183939|Methanococci	183939|Methanococci	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3065889_6	263820.PTO0891	3.375e-16	84.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX9F@28890|Euryarchaeota,242E7@183967|Thermoplasmata	183967|Thermoplasmata	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMD2_k127_3065889_0	1379698.RBG1_1C00001G1833	2.584e-125	413.0	COG1379@1|root,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
MMD2_k127_3065889_1	1054217.TALC_00034	9.563e-112	369.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,241KI@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GMP_synt_C,NAD_synthase
MMD2_k127_3065889_11	1254432.SCE1572_06015	2.65e-05	57.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WMWM@28221|Deltaproteobacteria,2YU7P@29|Myxococcales	28221|Deltaproteobacteria	T	Protein serine threonine phosphatase	pph1	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
MMD2_k127_3065889_10	1045858.Bint_0753	3.595e-06	56.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
MMD2_k127_3128204_3	368408.Tpen_0360	2.547e-08	60.0	COG2511@1|root,arCOG01719@2157|Archaea,2XPPH@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
MMD2_k127_3128204_1	756883.Halar_1394	2.569e-11	75.0	COG2064@1|root,arCOG01808@2157|Archaea	2157|Archaea	NU	Type II secretion system	pilC1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_3128204_2	339860.Msp_1163	5e-09	67.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y780@28890|Euryarchaeota,23P2D@183925|Methanobacteria	183925|Methanobacteria	N	type II secretion	gspF1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_3128204_0	391623.TERMP_01899	5.339e-84	301.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,242XB@183968|Thermococci	183968|Thermococci	U	type II secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Intein_splicing,LAGLIDADG_3,T2SSE
MMD2_k127_3150395_0	204536.SULAZ_0173	7.131e-47	175.0	COG2078@1|root,COG2078@2|Bacteria,2G44K@200783|Aquificae	200783|Aquificae	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMD2_k127_3156615_1	439481.Aboo_0182	7.213e-72	250.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,3F2GE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMD2_k127_3156615_6	868131.MSWAN_0460	1.979e-32	133.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,23P36@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
MMD2_k127_3156615_2	693661.Arcve_1049	8.172e-58	209.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,246MV@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosome maturation protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
MMD2_k127_3156615_5	401526.TcarDRAFT_0263	6.537e-45	181.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4H2XA@909932|Negativicutes	909932|Negativicutes	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMD2_k127_3156615_0	246969.TAM4_2345	1.285e-100	339.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,242Y2@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMD2_k127_3156615_3	394221.Mmar10_1682	2.26e-57	217.0	COG2730@1|root,COG2730@2|Bacteria,1PUWU@1224|Proteobacteria,2V6EP@28211|Alphaproteobacteria,43ZQQ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3156615_11	339860.Msp_1125	2.31e-07	61.0	COG1378@1|root,arCOG02037@2157|Archaea,2XZRE@28890|Euryarchaeota,23P59@183925|Methanobacteria	183925|Methanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMD2_k127_3156615_8	760011.Spico_1809	1.185e-14	87.0	COG0574@1|root,COG0745@1|root,COG0574@2|Bacteria,COG0745@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N,Response_reg
MMD2_k127_3156615_7	1121920.AUAU01000007_gene405	8.457e-31	139.0	COG0574@1|root,COG0574@2|Bacteria,3Y7G5@57723|Acidobacteria	57723|Acidobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
MMD2_k127_3156615_9	1080067.BAZH01000029_gene1425	3.637e-12	80.0	COG2373@1|root,COG3420@1|root,COG2373@2|Bacteria,COG3420@2|Bacteria,1QV7E@1224|Proteobacteria,1SM3U@1236|Gammaproteobacteria,3WZU8@544|Citrobacter	1236|Gammaproteobacteria	P	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2
MMD2_k127_3156615_10	1054217.TALC_00172	1.154e-09	62.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,241TQ@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMD2_k127_3156615_4	572546.Arcpr_0362	3.272e-51	191.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2463Z@183980|Archaeoglobi	183980|Archaeoglobi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMD2_k127_3156615_12	694440.JOMF01000005_gene144	0.0002035	46.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMD2_k127_3160806_0	391623.TERMP_00716	6.196e-221	710.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,242Z0@183968|Thermococci	183968|Thermococci	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD2_k127_3160806_1	489825.LYNGBM3L_10620	4.22e-32	141.0	COG3315@1|root,COG3315@2|Bacteria,1G5DY@1117|Cyanobacteria,1HFS2@1150|Oscillatoriales	1117|Cyanobacteria	H	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
MMD2_k127_3160806_2	224325.AF_0782	5.296e-08	59.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2474H@183980|Archaeoglobi	183980|Archaeoglobi	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
MMD2_k127_3160806_3	69014.TK1787	0.0001472	51.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,243G3@183968|Thermococci	183968|Thermococci	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
MMD2_k127_3171880_2	224325.AF_1529	2.59e-12	71.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,246FB@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMD2_k127_3171880_3	195522.BD01_0299	0.000132	48.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,244DX@183968|Thermococci	183968|Thermococci	K	RNA polymerase Rpb4	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMD2_k127_3171880_0	565033.GACE_1388	7.005e-46	172.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,246VN@183980|Archaeoglobi	183980|Archaeoglobi	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMD2_k127_3171880_1	263820.PTO1340	3.881e-32	128.0	COG1405@1|root,arCOG01981@2157|Archaea,2XU76@28890|Euryarchaeota,2422B@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbB	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMD2_k127_3192590_3	694429.Pyrfu_1681	9.452e-17	85.0	COG0200@1|root,arCOG00779@2157|Archaea,2XQH0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMD2_k127_3192590_0	644281.MFS40622_1749	1.233e-100	344.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,23QHI@183939|Methanococci	183939|Methanococci	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
MMD2_k127_3192590_1	1220534.B655_1488	2.208e-36	143.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23NZH@183925|Methanobacteria	183925|Methanobacteria	F	Belongs to the archaeal adenylate kinase family	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
MMD2_k127_3192590_4	364733.XP_007802551.1	3.064e-05	52.0	COG0346@1|root,KOG2944@2759|Eukaryota,38CS6@33154|Opisthokonta,3NVC4@4751|Fungi,3QJCR@4890|Ascomycota,20CCG@147545|Eurotiomycetes,3MPZD@451870|Chaetothyriomycetidae	4751|Fungi	G	Lactoylglutathione lyase	GLO1	GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009438,GO:0009628,GO:0009636,GO:0009987,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042180,GO:0042182,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051596,GO:0051716,GO:0061727,GO:0070887,GO:0071214,GO:0071470,GO:0071704,GO:0097237,GO:0098754,GO:0104004,GO:1901564,GO:1901575,GO:1901615,GO:1990748	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
MMD2_k127_3192590_2	1459636.NTE_00936	2.902e-22	97.0	COG0151@1|root,arCOG04415@2157|Archaea	2157|Archaea	F	Belongs to the GARS family	purD1	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C
MMD2_k127_3193479_12	868864.Dester_0334	1.533e-18	98.0	COG0420@1|root,COG0420@2|Bacteria,2G45D@200783|Aquificae	200783|Aquificae	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
MMD2_k127_3193479_8	439481.Aboo_0457	1.346e-47	177.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,3F2IP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Aldolase/RraA	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
MMD2_k127_3193479_6	748727.CLJU_c00570	2.574e-66	234.0	COG2020@1|root,COG2020@2|Bacteria,1V0PB@1239|Firmicutes,24AQ6@186801|Clostridia,36I4M@31979|Clostridiaceae	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
MMD2_k127_3193479_11	1286171.EAL2_c07880	5.04e-24	108.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes,24HUR@186801|Clostridia	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
MMD2_k127_3193479_2	766499.C357_09917	3.175e-122	406.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	phlC	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF35_N,Thiolase_C,Thiolase_N,ketoacyl-synt
MMD2_k127_3193479_15	1123312.KB904581_gene1214	6.716e-15	83.0	COG1545@1|root,COG1545@2|Bacteria,1V3AC@1239|Firmicutes,4IUUU@91061|Bacilli	91061|Bacilli	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N
MMD2_k127_3193479_17	936140.AEOT01000015_gene1486	8.171e-10	62.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,4HNQ0@91061|Bacilli,3F7F4@33958|Lactobacillaceae	91061|Bacilli	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
MMD2_k127_3193479_14	1122216.AUHW01000004_gene1661	3.659e-16	88.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,4H55G@909932|Negativicutes	909932|Negativicutes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
MMD2_k127_3193479_1	243275.TDE_0933	5.694e-123	408.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
MMD2_k127_3193479_5	373903.Hore_10200	4.255e-78	273.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,3WABQ@53433|Halanaerobiales	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
MMD2_k127_3193479_0	880072.Desac_2581	1.135e-172	559.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2MRF6@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMD2_k127_3193479_10	1459636.NTE_00652	1.317e-41	157.0	COG0494@1|root,arCOG01078@2157|Archaea,41SPS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMD2_k127_3193479_18	304371.MCP_0806	2.827e-07	53.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota,2NB9F@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMD2_k127_3193479_13	1235279.C772_00898	1.113e-16	85.0	COG0537@1|root,COG0537@2|Bacteria,1V8G5@1239|Firmicutes,4IR7A@91061|Bacilli	91061|Bacilli	FG	HIT family	-	-	-	-	-	-	-	-	-	-	-	-	HIT
MMD2_k127_3193479_9	70601.3257969	1.68e-44	171.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,243D7@183968|Thermococci	183968|Thermococci	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMD2_k127_3193479_7	579137.Metvu_1529	5.068e-52	190.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,23QKA@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMD2_k127_3193479_3	868131.MSWAN_1874	4.932e-85	287.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
MMD2_k127_3193479_19	309800.C498_13239	0.0001275	53.0	arCOG04389@1|root,arCOG04389@2157|Archaea,2XYJM@28890|Euryarchaeota,23WHG@183963|Halobacteria	183963|Halobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3193479_4	453591.Igni_0465	3.335e-79	277.0	COG1384@1|root,arCOG00485@2157|Archaea,2XPT9@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMD2_k127_3199745_1	1507.HMPREF0262_02043	1.513e-51	190.0	COG0461@1|root,COG0461@2|Bacteria,1TREW@1239|Firmicutes,248WM@186801|Clostridia,36ETX@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMD2_k127_3199745_2	1122216.AUHW01000035_gene1207	2.591e-50	190.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,4H2VU@909932|Negativicutes	909932|Negativicutes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMD2_k127_3199745_0	572546.Arcpr_0988	8.482e-105	346.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMD2_k127_3199745_3	386456.JQKN01000002_gene2680	6.942e-25	117.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,23NUG@183925|Methanobacteria	183925|Methanobacteria	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
MMD2_k127_3209668_2	693661.Arcve_0846	1.159e-101	350.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,245T6@183980|Archaeoglobi	183980|Archaeoglobi	J	phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
MMD2_k127_3209668_7	304371.MCP_0377	4.352e-31	133.0	COG0705@1|root,COG3582@1|root,arCOG01768@2157|Archaea,arCOG01769@2157|Archaea,2XTJH@28890|Euryarchaeota,2N9X9@224756|Methanomicrobia	224756|Methanomicrobia	E	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
MMD2_k127_3209668_1	293826.Amet_0922	8.58e-119	397.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,36ECS@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMD2_k127_3209668_11	593750.Metfor_1995	1.461e-09	67.0	COG0640@1|root,arCOG01683@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_20,HTH_24,HTH_5,PadR
MMD2_k127_3209668_0	456442.Mboo_0156	1.38e-157	506.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
MMD2_k127_3209668_9	192952.MM_2895	6.392e-23	99.0	COG1476@1|root,arCOG01864@2157|Archaea,2Y089@28890|Euryarchaeota,2NA1I@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMD2_k127_3209668_8	1321779.HMPREF1984_01537	5.992e-28	122.0	COG0036@1|root,COG0036@2|Bacteria,379G5@32066|Fusobacteria	32066|Fusobacteria	G	Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMD2_k127_3209668_3	580340.Tlie_1478	6.322e-99	331.0	COG3959@1|root,COG3959@2|Bacteria,3TA23@508458|Synergistetes	508458|Synergistetes	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMD2_k127_3209668_4	1449126.JQKL01000014_gene2985	1.718e-95	323.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,268B4@186813|unclassified Clostridiales	186801|Clostridia	G	Transketolase, pyrimidine binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
MMD2_k127_3209668_5	273068.TTE1918	9.191e-83	280.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,42EPM@68295|Thermoanaerobacterales	186801|Clostridia	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
MMD2_k127_3209668_6	634498.mru_2201	6.166e-44	163.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,23P3X@183925|Methanobacteria	183925|Methanobacteria	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMD2_k127_3209668_10	195522.BD01_0373	1.478e-17	83.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota,2440F@183968|Thermococci	183968|Thermococci	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
MMD2_k127_3210547_0	926569.ANT_09500	9.85e-50	186.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
MMD2_k127_3210547_1	1316936.K678_01186	3.453e-26	114.0	COG3428@1|root,COG3428@2|Bacteria,1N9PB@1224|Proteobacteria,2TUD0@28211|Alphaproteobacteria,2JU7A@204441|Rhodospirillales	204441|Rhodospirillales	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
MMD2_k127_3210547_2	370438.PTH_2726	3.295e-23	104.0	COG0110@1|root,COG0110@2|Bacteria,1V1SM@1239|Firmicutes,25B93@186801|Clostridia,26395@186807|Peptococcaceae	186801|Clostridia	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
MMD2_k127_3219484_0	635013.TherJR_0353	1.016e-64	231.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,2608G@186807|Peptococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
MMD2_k127_3219484_1	243164.DET0106	3.595e-05	54.0	COG1704@1|root,COG1704@2|Bacteria,2G7BN@200795|Chloroflexi,34CYN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE,LemA
MMD2_k127_3232520_9	203275.BFO_2675	3.243e-07	63.0	COG4249@1|root,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C13,Peptidase_C14
MMD2_k127_3232520_6	419665.Maeo_0199	3.164e-16	82.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,23R51@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMD2_k127_3232520_0	304371.MCP_2998	2.548e-96	332.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
MMD2_k127_3232520_1	391625.PPSIR1_10555	3.071e-71	261.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMD2_k127_3232520_7	387631.Asulf_00521	3.19e-10	72.0	COG3979@1|root,COG5306@1|root,arCOG02420@1|root,arCOG03511@1|root,arCOG03553@1|root,arCOG09173@1|root,arCOG02420@2157|Archaea,arCOG03508@2157|Archaea,arCOG03511@2157|Archaea,arCOG03553@2157|Archaea,arCOG07581@2157|Archaea,arCOG09173@2157|Archaea	2157|Archaea	C	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,DUF2341,PKD,Pilin_N,S_layer_C
MMD2_k127_3232520_11	572546.Arcpr_1444	0.0003982	46.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMD2_k127_3232520_2	572546.Arcpr_0017	2.179e-40	157.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,2469H@183980|Archaeoglobi	183980|Archaeoglobi	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
MMD2_k127_3232520_8	932678.THERU_03245	9.447e-10	65.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	fdx	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
MMD2_k127_3232520_10	948106.AWZT01000029_gene785	0.0001782	52.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2VX9Q@28216|Betaproteobacteria,1KA54@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
MMD2_k127_3232520_3	1321778.HMPREF1982_02750	1.839e-29	125.0	COG0637@1|root,COG0637@2|Bacteria,1V1NW@1239|Firmicutes,24G37@186801|Clostridia	186801|Clostridia	J	IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,HAD_2
MMD2_k127_3232520_4	368407.Memar_0641	1.582e-18	98.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,2N92W@224756|Methanomicrobia	224756|Methanomicrobia	J	sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
MMD2_k127_3232520_5	485913.Krac_12332	1.844e-18	89.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMD2_k127_3236137_16	484770.UFO1_3656	1.082e-05	53.0	2E5YB@1|root,330N1@2|Bacteria,1VEVQ@1239|Firmicutes,4H89P@909932|Negativicutes	909932|Negativicutes	S	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Zn_ribbon_2
MMD2_k127_3236137_3	573063.Metin_0058	4.148e-114	378.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD2_k127_3236137_17	589924.Ferp_1560	3.493e-05	50.0	COG1753@1|root,arCOG02681@2157|Archaea,2Y4IQ@28890|Euryarchaeota	28890|Euryarchaeota	K	Possibly the antitoxin component of a	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
MMD2_k127_3236137_14	693661.Arcve_1707	1.345e-11	69.0	COG1487@1|root,arCOG02219@2157|Archaea,2Y0RE@28890|Euryarchaeota,2475N@183980|Archaeoglobi	183980|Archaeoglobi	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
MMD2_k127_3236137_5	1041930.Mtc_1211	1.141e-76	266.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,2N9HC@224756|Methanomicrobia	224756|Methanomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2755	GATase_5
MMD2_k127_3236137_15	1463934.JOCF01000059_gene3315	9.179e-08	63.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	-	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
MMD2_k127_3236137_6	523850.TON_1373	2.689e-67	235.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,243MS@183968|Thermococci	183968|Thermococci	K	Helix-turn-helix domain	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_19,HTH_3
MMD2_k127_3236137_1	572544.Ilyop_0622	4.534e-170	549.0	COG0504@1|root,COG0504@2|Bacteria,378S0@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMD2_k127_3236137_2	1343739.PAP_04700	4.65e-162	532.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,243N1@183968|Thermococci	183968|Thermococci	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
MMD2_k127_3236137_12	591019.Shell_0641	2.524e-15	83.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_3236137_10	1047013.AQSP01000099_gene1494	1.245e-31	136.0	COG0237@1|root,COG0237@2|Bacteria	2|Bacteria	H	dephospho-CoA kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
MMD2_k127_3236137_7	313628.LNTAR_01145	4.148e-55	205.0	COG2131@1|root,COG2131@2|Bacteria	2|Bacteria	F	dCMP deaminase activity	dcdA	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMD2_k127_3236137_18	1469557.JSWF01000028_gene2785	4.792e-05	57.0	COG2356@1|root,COG3227@1|root,COG3291@1|root,COG2356@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,4NF8H@976|Bacteroidetes,1IJ61@117743|Flavobacteriia	976|Bacteroidetes	E	Thermolysin metallopeptidase, catalytic domain	-	-	3.4.24.28	ko:K01400	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF5011,FTP,Inhibitor_I69,MAM,Peptidase_C10,Peptidase_M14,Peptidase_M4,Peptidase_M43,Peptidase_M4_C,Reprolysin_4,fn3
MMD2_k127_3236137_13	224325.AF_1947	6.296e-13	78.0	COG3042@1|root,arCOG12676@2157|Archaea,2Y52K@28890|Euryarchaeota,247DJ@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF333)	-	-	-	ko:K09712	-	-	-	-	ko00000	-	-	-	DUF333
MMD2_k127_3236137_8	523845.AQXV01000050_gene986	3.982e-41	161.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,23QGA@183939|Methanococci	183939|Methanococci	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
MMD2_k127_3236137_0	643648.Slip_1577	0.0	1119.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,42JIN@68298|Syntrophomonadaceae	186801|Clostridia	F	Carbamoyl-phosphate synthetase ammonia chain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMD2_k127_3236137_4	1121472.AQWN01000003_gene1405	7.772e-114	377.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,261AS@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
MMD2_k127_3236137_9	304371.MCP_1403	1.425e-38	146.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
MMD2_k127_3236137_11	358681.BBR47_51990	6.291e-27	128.0	COG5492@1|root,COG5492@2|Bacteria,1V706@1239|Firmicutes,4IQ3I@91061|Bacilli	91061|Bacilli	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_3_2,Cadherin
MMD2_k127_3242521_7	269797.Mbar_A0198	1.027e-16	87.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMD2_k127_3242521_6	679926.Mpet_0042	5.804e-24	114.0	COG0392@1|root,COG0500@1|root,arCOG00899@2157|Archaea,arCOG04347@2157|Archaea,2Y7ZD@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3242521_2	247490.KSU1_C0385	1.281e-48	181.0	COG0590@1|root,COG0590@2|Bacteria,2J0TT@203682|Planctomycetes	203682|Planctomycetes	FJ	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	MafB19-deam,dCMP_cyt_deam_1
MMD2_k127_3242521_5	351160.RCIX1194	8.738e-29	124.0	COG2020@1|root,arCOG03580@2157|Archaea,2XXNN@28890|Euryarchaeota	28890|Euryarchaeota	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
MMD2_k127_3242521_8	1209989.TepiRe1_2456	1.234e-07	56.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,42H6Q@68295|Thermoanaerobacterales	186801|Clostridia	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
MMD2_k127_3242521_3	666510.ASAC_0749	1.6e-36	154.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPXH@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
MMD2_k127_3242521_0	1121430.JMLG01000013_gene1880	3.115e-272	852.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,260TY@186807|Peptococcaceae	186801|Clostridia	C	Aconitase family (aconitate hydratase)	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMD2_k127_3242521_1	247490.KSU1_D0121	1.299e-173	555.0	COG0538@1|root,COG0538@2|Bacteria,2J51C@203682|Planctomycetes	203682|Planctomycetes	C	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
MMD2_k127_3242521_4	3885.XP_007149129.1	8.477e-32	128.0	COG0045@1|root,KOG1254@2759|Eukaryota,37IP2@33090|Viridiplantae,3GCZE@35493|Streptophyta,4JFIS@91835|fabids	35493|Streptophyta	C	ATP-citrate synthase alpha chain protein	ACLA-1	GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	ATP-grasp_2,Citrate_bind
MMD2_k127_3276842_1	926569.ANT_13220	1.586e-69	251.0	COG0018@1|root,COG0018@2|Bacteria,2G6DK@200795|Chloroflexi	200795|Chloroflexi	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMD2_k127_3276842_0	56780.SYN_00521	5.46e-303	961.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MR4G@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
MMD2_k127_3276842_3	1183377.Py04_1359	4.582e-41	162.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMD2_k127_3276842_2	644966.Tmar_0214	2.849e-56	214.0	COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
MMD2_k127_3276842_4	216591.BCAL1149	1.368e-05	57.0	COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria,1K1JR@119060|Burkholderiaceae	28216|Betaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMD2_k127_3276842_5	1433126.BN938_1537	0.0007872	51.0	COG4299@1|root,COG4299@2|Bacteria,4NGKU@976|Bacteroidetes,2FQUY@200643|Bacteroidia,22VFH@171550|Rikenellaceae	976|Bacteroidetes	S	Domain of unknown function (DUF5009)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5009
MMD2_k127_3310056_1	192952.MM_0113	0.000735	52.0	COG1305@1|root,arCOG03600@2157|Archaea,2Y7F7@28890|Euryarchaeota,2NA6Q@224756|Methanomicrobia	224756|Methanomicrobia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
MMD2_k127_3310056_0	523845.AQXV01000025_gene1487	1.365e-32	131.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,23QZN@183939|Methanococci	183939|Methanococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMD2_k127_3347237_2	536227.CcarbDRAFT_2514	5.328e-28	117.0	COG1661@1|root,COG1661@2|Bacteria,1VBWE@1239|Firmicutes,24HQ2@186801|Clostridia,36K5V@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMD2_k127_3347237_3	1283284.AZUK01000001_gene1930	8.818e-08	64.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1S3FN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
MMD2_k127_3347237_1	529709.PYCH_07510	9.568e-40	151.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,2441P@183968|Thermococci	183968|Thermococci	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
MMD2_k127_3347237_0	439481.Aboo_1121	5.936e-75	259.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,3F2F5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1168	OTCace,OTCace_N
MMD2_k127_3369231_2	402880.MmarC5_0443	9.148e-09	62.0	COG1407@1|root,arCOG01150@2157|Archaea,2XWNG@28890|Euryarchaeota,23R1X@183939|Methanococci	183939|Methanococci	S	PFAM Metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
MMD2_k127_3369231_0	386456.JQKN01000015_gene2931	1.164e-64	238.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,23NMV@183925|Methanobacteria	183925|Methanobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMD2_k127_3369231_1	444157.Tneu_1737	6.788e-15	85.0	COG1199@1|root,arCOG00770@2157|Archaea,2XPRS@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM DEAD_2 domain protein	-	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0043139,GO:0048037,GO:0051276,GO:0051536,GO:0051539,GO:0051540,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
MMD2_k127_3374701_2	224325.AF_2058	2.948e-49	189.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2463A@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMD2_k127_3374701_6	246969.TAM4_606	1.194e-21	105.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,243T0@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
MMD2_k127_3374701_9	439481.Aboo_1383	7.109e-08	57.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,3F2UR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
MMD2_k127_3374701_10	444157.Tneu_0985	5.875e-06	58.0	COG0681@1|root,arCOG01739@2157|Archaea,2XQV6@28889|Crenarchaeota	28889|Crenarchaeota	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
MMD2_k127_3374701_8	1112217.PPL19_04450	5.923e-10	67.0	COG1670@1|root,COG1670@2|Bacteria,1RH19@1224|Proteobacteria,1T1HK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	acetyltransferase	yhhY	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
MMD2_k127_3374701_3	1198449.ACAM_0725	3.31e-42	164.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMD2_k127_3374701_4	604354.TSIB_1270	9.997e-35	138.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,243T7@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMD2_k127_3374701_5	1220534.B655_0203	3.379e-29	124.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,23NZE@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
MMD2_k127_3374701_7	387631.Asulf_00724	3.949e-21	97.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,2476E@183980|Archaeoglobi	183980|Archaeoglobi	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
MMD2_k127_3374701_0	224325.AF_1435	3.002e-83	287.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,246P0@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
MMD2_k127_3374701_1	565033.GACE_1308	1.11e-76	272.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,245T5@183980|Archaeoglobi	183980|Archaeoglobi	L	phosphoesterase RecJ domain protein	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
MMD2_k127_3440757_2	1267534.KB906755_gene4707	6.685e-39	148.0	COG3189@1|root,COG3189@2|Bacteria	2|Bacteria	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
MMD2_k127_3440757_0	391623.TERMP_00178	1.944e-55	208.0	COG1423@1|root,arCOG04218@2157|Archaea,2XUD4@28890|Euryarchaeota,243KS@183968|Thermococci	183968|Thermococci	L	DNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
MMD2_k127_3440757_1	593117.TGAM_0479	2.611e-42	162.0	COG1458@1|root,arCOG00720@2157|Archaea,2XUK7@28890|Euryarchaeota,243PP@183968|Thermococci	183968|Thermococci	V	Belongs to the UPF0278 family	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	PIN_5
MMD2_k127_348566_3	555079.Toce_0685	4.848e-77	273.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,42EM6@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMD2_k127_348566_1	670487.Ocepr_1655	2.307e-83	285.0	COG0190@1|root,COG0190@2|Bacteria,1WI3X@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMD2_k127_348566_2	868131.MSWAN_1950	3.328e-78	278.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,23PHA@183925|Methanobacteria	183925|Methanobacteria	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B_2,RMMBL
MMD2_k127_348566_4	565033.GACE_0188	9.178e-22	104.0	COG0637@1|root,arCOG02293@2157|Archaea,2Y7WB@28890|Euryarchaeota,246TW@183980|Archaeoglobi	183980|Archaeoglobi	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMD2_k127_35821_0	342949.PNA2_1805	1.313e-28	124.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,243IC@183968|Thermococci	183968|Thermococci	E	Glutamine amidotransferase domain	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
MMD2_k127_388010_0	589924.Ferp_0592	8.278e-60	226.0	COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,246V1@183980|Archaeoglobi	183980|Archaeoglobi	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
MMD2_k127_3932534_5	1094980.Mpsy_2088	8.454e-34	143.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MI@28890|Euryarchaeota,2NBNK@224756|Methanomicrobia	28890|Euryarchaeota	T	Pfam:KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD2_k127_3932534_7	1499689.CCNN01000007_gene2465	5.249e-18	85.0	COG2002@1|root,COG2002@2|Bacteria,1VDAQ@1239|Firmicutes,24RPD@186801|Clostridia,36VJA@31979|Clostridiaceae	186801|Clostridia	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
MMD2_k127_3932534_1	1094980.Mpsy_1852	2.627e-105	352.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	224756|Methanomicrobia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD2_k127_3932534_2	1094980.Mpsy_1853	7.849e-62	221.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,2N9R3@224756|Methanomicrobia	224756|Methanomicrobia	V	TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMD2_k127_3932534_8	1173021.ALWA01000022_gene649	0.0009338	49.0	COG4272@1|root,COG4272@2|Bacteria,1G77S@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1634)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
MMD2_k127_3932534_3	243231.GSU0268	5.607e-56	206.0	COG0730@1|root,COG0730@2|Bacteria,1NJ47@1224|Proteobacteria,42QRS@68525|delta/epsilon subdivisions,2WN5M@28221|Deltaproteobacteria,43UD4@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMD2_k127_3932534_0	1121468.AUBR01000045_gene1791	4.055e-149	487.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,42FGT@68295|Thermoanaerobacterales	186801|Clostridia	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
MMD2_k127_3932534_4	1242864.D187_000131	9.971e-35	150.0	2DBMS@1|root,2ZA09@2|Bacteria,1QVQY@1224|Proteobacteria,433A0@68525|delta/epsilon subdivisions,2WXKN@28221|Deltaproteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3932534_6	589924.Ferp_1786	5.708e-26	115.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,24660@183980|Archaeoglobi	183980|Archaeoglobi	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
MMD2_k127_3950580_3	1183377.Py04_0330	0.0002773	49.0	COG1390@1|root,arCOG00869@2157|Archaea,2XWGX@28890|Euryarchaeota,243A6@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
MMD2_k127_3950580_2	1121380.JNIW01000016_gene2520	1.26e-07	56.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMD2_k127_3950580_0	192952.MM_0785	1.291e-54	214.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,2N9EB@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the V-ATPase 116 kDa subunit family	atpI-1	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMD2_k127_3950580_1	593117.TGAM_1800	3.176e-38	149.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMD2_k127_3978980_1	883069.HMPREF9238_00056	5.682e-05	53.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4D3Y1@85005|Actinomycetales	201174|Actinobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMD2_k127_3978980_0	272557.APE_0662.1	1.303e-79	280.0	COG0124@1|root,arCOG00404@2157|Archaea,2XPY6@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMD2_k127_4051099_1	572546.Arcpr_1661	3.29e-59	213.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,2461V@183980|Archaeoglobi	183980|Archaeoglobi	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMD2_k127_4051099_4	365046.Rta_02860	0.0004823	52.0	COG3012@1|root,COG3012@2|Bacteria,1QUG4@1224|Proteobacteria,2WH4S@28216|Betaproteobacteria,4AB03@80864|Comamonadaceae	28216|Betaproteobacteria	S	SEC-C motif domain protein	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
MMD2_k127_4051099_2	634498.mru_0670	2.686e-13	81.0	COG2064@1|root,arCOG01811@2157|Archaea,2Y71N@28890|Euryarchaeota,23P0K@183925|Methanobacteria	183925|Methanobacteria	N	Type II secretion system	gspF2	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_4051099_3	877455.Metbo_0461	4.706e-10	70.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y780@28890|Euryarchaeota,23P2D@183925|Methanobacteria	183925|Methanobacteria	N	type II secretion	gspF1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_4051099_0	391623.TERMP_01899	1.264e-102	353.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,242XB@183968|Thermococci	183968|Thermococci	U	type II secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Intein_splicing,LAGLIDADG_3,T2SSE
MMD2_k127_4069869_3	1007096.BAGW01000019_gene565	3.215e-12	68.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,2N8MF@216572|Oscillospiraceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
MMD2_k127_4069869_0	243232.MJ_1326	1.328e-120	398.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23QKG@183939|Methanococci	183939|Methanococci	S	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
MMD2_k127_4069869_1	1537715.JQFJ01000002_gene415	6.921e-98	353.0	COG1222@1|root,COG1222@2|Bacteria,1QTV4@1224|Proteobacteria,2U0Q7@28211|Alphaproteobacteria,2K0N9@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the AAA ATPase family	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMD2_k127_4069869_2	1262449.CP6013_0270	2.388e-15	77.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,36F0H@31979|Clostridiaceae	186801|Clostridia	C	biosynthesis protein ThiH	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
MMD2_k127_4127231_10	572546.Arcpr_0278	7.282e-25	109.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,246NW@183980|Archaeoglobi	183980|Archaeoglobi	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMD2_k127_4127231_15	887062.HGR_14694	0.0004679	46.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,4AFBH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
MMD2_k127_4127231_5	877455.Metbo_2522	3.264e-52	190.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota,23PEX@183925|Methanobacteria	183925|Methanobacteria	M	PFAM Sugar isomerase (SIS)	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
MMD2_k127_4127231_2	351160.RCIX2726	2.581e-130	441.0	COG1948@1|root,arCOG02284@2157|Archaea,2XT7B@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Beta propeller domain	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Beta_propel,Inhibitor_I42
MMD2_k127_4127231_6	864565.HMPREF0379_1367	5.813e-45	179.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,25QSU@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
MMD2_k127_4127231_11	387631.Asulf_01814	1.799e-10	72.0	arCOG07525@1|root,arCOG10344@1|root,arCOG07525@2157|Archaea,arCOG10344@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4127231_7	591019.Shell_1217	1.461e-40	164.0	COG0462@1|root,arCOG00067@2157|Archaea,2XQE3@28889|Crenarchaeota	28889|Crenarchaeota	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
MMD2_k127_4127231_8	1123376.AUIU01000014_gene712	2.981e-36	145.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI3	-	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DJ-1_PfpI
MMD2_k127_4127231_12	743525.TSC_c17550	5.909e-07	54.0	COG1146@1|root,COG1146@2|Bacteria,1WK70@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMD2_k127_4127231_3	1343739.PAP_07210	7.262e-74	265.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,242WU@183968|Thermococci	183968|Thermococci	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3
MMD2_k127_4127231_13	273063.STK_09430	3.874e-06	59.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMD2_k127_4127231_0	357808.RoseRS_0926	5.287e-160	530.0	COG1351@1|root,COG1351@2|Bacteria,2G8EZ@200795|Chloroflexi,374YN@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
MMD2_k127_4127231_14	1440052.EAKF1_ch4134	0.000227	53.0	COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,1RRDM@1236|Gammaproteobacteria,3XMQH@561|Escherichia	1236|Gammaproteobacteria	S	Belongs to the UPF0149 family	yecA	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
MMD2_k127_4127231_4	572546.Arcpr_0989	7.885e-62	224.0	COG0451@1|root,arCOG01369@2157|Archaea	2157|Archaea	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
MMD2_k127_4127231_9	1459636.NTE_01071	4.469e-26	118.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMD2_k127_4127231_1	243232.MJ_1546	3.78e-144	465.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,23Q7Q@183939|Methanococci	183939|Methanococci	I	Belongs to the UPF0219 family	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
MMD2_k127_4135186_5	1996.JOFO01000078_gene4201	6.591e-31	127.0	COG1896@1|root,COG1896@2|Bacteria,2I8SJ@201174|Actinobacteria,4EIX4@85012|Streptosporangiales	201174|Actinobacteria	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
MMD2_k127_4135186_6	999630.TUZN_1163	2.73e-10	69.0	COG0235@1|root,arCOG04226@2157|Archaea,2XQS6@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM class II aldolase adducin family protein	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
MMD2_k127_4135186_0	1304880.JAGB01000001_gene848	8.266e-83	285.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia	186801|Clostridia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
MMD2_k127_4135186_4	1123371.ATXH01000001_gene1262	5.086e-33	134.0	COG0212@1|root,COG0212@2|Bacteria,2GH6Y@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
MMD2_k127_4135186_7	1476876.JOJO01000014_gene7091	1.286e-05	55.0	COG2755@1|root,COG2755@2|Bacteria,2GMDE@201174|Actinobacteria	201174|Actinobacteria	E	GDSL-like Lipase/Acylhydrolase	plb1	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
MMD2_k127_4135186_1	591019.Shell_1137	1.183e-52	195.0	COG0647@1|root,arCOG04221@2157|Archaea,2XQZD@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
MMD2_k127_4135186_3	1347368.HG964406_gene6269	4.569e-35	144.0	COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,4HA3R@91061|Bacilli,1ZB73@1386|Bacillus	91061|Bacilli	G	Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro	nagD	-	3.1.3.41	ko:K01101	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
MMD2_k127_4135186_2	593117.TGAM_1854	1.486e-46	175.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,242TE@183968|Thermococci	183968|Thermococci	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMD2_k127_4162313_0	237368.SCABRO_02056	3.485e-104	351.0	COG0298@1|root,COG0502@1|root,COG0298@2|Bacteria,COG0502@2|Bacteria	2|Bacteria	H	biotin synthase activity	hypC	-	2.8.1.6	ko:K01012,ko:K04653	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS11355	BATS,HupF_HypC,Radical_SAM
MMD2_k127_4162313_1	292459.STH354	1.382e-87	297.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia	186801|Clostridia	C	biosynthesis protein ThiH	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
MMD2_k127_4191793_2	1293048.CBMB010000001_gene505	2.978e-82	290.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23SSW@183963|Halobacteria	183963|Halobacteria	G	Belongs to the phosphohexose mutase family	pmm1	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMD2_k127_4191793_1	273063.STK_13870	2.478e-88	308.0	COG0174@1|root,arCOG01909@2157|Archaea,2XPM9@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Glutamine synthetase, catalytic	glnA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMD2_k127_4191793_4	243232.MJ_0281	2.122e-28	121.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
MMD2_k127_4191793_3	1123368.AUIS01000003_gene1806	5.467e-55	200.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,LUD_dom,SnoaL_3,SnoaL_4
MMD2_k127_4191793_0	1094980.Mpsy_0403	2.503e-89	304.0	COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMD2_k127_4201220_0	673860.AciM339_1104	1.355e-32	135.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,3F2JC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S3	rps3	GO:0000702,GO:0002181,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003735,GO:0003824,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006281,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008534,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMD2_k127_4201220_1	868131.MSWAN_1463	1.21e-25	109.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23PKF@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
MMD2_k127_4201220_2	1220534.B655_1503	8.88e-16	81.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
MMD2_k127_4217729_3	138119.DSY1754	4.82e-22	110.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,260IQ@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMD2_k127_4217729_4	906968.Trebr_1259	1.776e-17	92.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMD2_k127_4217729_2	521045.Kole_2169	1.421e-74	260.0	COG0111@1|root,COG0111@2|Bacteria,2GEGH@200918|Thermotogae	200918|Thermotogae	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMD2_k127_4217729_5	639282.DEFDS_0963	1.098e-10	68.0	COG4747@1|root,COG4747@2|Bacteria,2GFKS@200930|Deferribacteres	200930|Deferribacteres	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
MMD2_k127_4217729_0	374847.Kcr_0401	7.945e-115	380.0	COG1759@1|root,arCOG04346@2157|Archaea	2157|Archaea	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMD2_k127_4217729_1	1459636.NTE_01419	5.315e-85	299.0	COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Phenylalanyl-tRNA synthetase alpha subunit	-	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMD2_k127_4280222_5	323259.Mhun_0629	2.189e-10	71.0	COG0655@1|root,arCOG02578@2157|Archaea	2157|Archaea	P	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD2_k127_4280222_6	157072.XP_008880236.1	0.0001533	51.0	2CMRT@1|root,2QRKV@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4280222_2	1459636.NTE_02880	5.618e-83	286.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMD2_k127_4280222_0	1041930.Mtc_0704	2.379e-203	651.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
MMD2_k127_4280222_4	604354.TSIB_1177	9.475e-15	86.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,243C5@183968|Thermococci	183968|Thermococci	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
MMD2_k127_4280222_3	633148.Tagg_1279	5.618e-15	82.0	COG1813@1|root,arCOG01863@2157|Archaea,2XQXA@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
MMD2_k127_4280222_1	694429.Pyrfu_0109	3.411e-101	340.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMD2_k127_4280222_7	457405.FSDG_01518	0.0003443	44.0	COG0009@1|root,COG0009@2|Bacteria,378B4@32066|Fusobacteria	32066|Fusobacteria	J	Belongs to the SUA5 family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
MMD2_k127_4314103_2	69319.XP_008549682.1	0.000129	53.0	KOG1218@1|root,KOG1218@2759|Eukaryota,3A5DU@33154|Opisthokonta,3BV6B@33208|Metazoa,3D8XT@33213|Bilateria,4204R@6656|Arthropoda,3SN32@50557|Insecta	33208|Metazoa	T	EB module	-	-	-	-	-	-	-	-	-	-	-	-	EB
MMD2_k127_4314103_0	456320.Mvol_0879	2.698e-45	172.0	COG1011@1|root,arCOG02291@2157|Archaea,2XTX3@28890|Euryarchaeota,23QPZ@183939|Methanococci	183939|Methanococci	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMD2_k127_4352255_1	666510.ASAC_0589	2.945e-08	57.0	COG0533@1|root,arCOG01185@2157|Archaea,2XQKE@28889|Crenarchaeota	28889|Crenarchaeota	T	Mn2 dependent serine threonine protein kinase	-	-	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	Pkinase,RIO1
MMD2_k127_4352255_0	573064.Mefer_1319	3.27e-314	998.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,23Q0E@183939|Methanococci	183939|Methanococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	Intein_splicing,LAGLIDADG_3,PolC_DP2
MMD2_k127_4352255_2	177439.DP2827	1.866e-05	48.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
MMD2_k127_4536381_4	1424334.W822_01525	1.225e-09	71.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2VMPB@28216|Betaproteobacteria,3T4G4@506|Alcaligenaceae	28216|Betaproteobacteria	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
MMD2_k127_4536381_5	227086.JGI_V11_31728	1.518e-06	56.0	COG0666@1|root,KOG0504@2759|Eukaryota	2759|Eukaryota	I	protein ubiquitination	-	-	2.3.1.225	ko:K15502,ko:K15503,ko:K20032,ko:K21440	-	-	-	-	ko00000,ko01000,ko01009,ko03400,ko04131	9.B.37.1,9.B.37.3	-	-	Ank_2,Ank_3,Ank_4,Ank_5,ZU5
MMD2_k127_4536381_3	1459636.NTE_01071	4.102e-22	105.0	COG1378@1|root,arCOG02037@2157|Archaea	2157|Archaea	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMD2_k127_4536381_0	391623.TERMP_01002	1.335e-148	482.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,24385@183968|Thermococci	183968|Thermococci	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMD2_k127_4536381_1	877455.Metbo_0990	1.458e-68	253.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,23NQU@183925|Methanobacteria	183925|Methanobacteria	S	phosphohydrolase	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMD2_k127_4536381_2	1094980.Mpsy_1456	3.951e-27	120.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMD2_k127_4623980_0	351160.RCIX691	7.562e-78	267.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2N9CH@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMD2_k127_4623980_1	647113.Metok_0553	1.744e-35	145.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23QU7@183939|Methanococci	183939|Methanococci	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4623980_2	374847.Kcr_1421	1.564e-25	115.0	COG0533@1|root,arCOG01185@2157|Archaea	2157|Archaea	F	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	kae1	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234,2.7.11.1	ko:K08851,ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,Pkinase,RIO1
MMD2_k127_4742684_3	1227488.C477_11157	3.774e-07	59.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,23T1Z@183963|Halobacteria	183963|Halobacteria	L	protein conserved in archaea	ginS	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
MMD2_k127_4742684_1	671065.MetMK1DRAFT_00029380	1.581e-10	64.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMD2_k127_4742684_2	416348.Hlac_1010	6.399e-10	61.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,23XGZ@183963|Halobacteria	183963|Halobacteria	J	Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMD2_k127_4742684_0	573063.Metin_0679	7.454e-44	169.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,23PZU@183939|Methanococci	183939|Methanococci	J	Translation initiation factor 2	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMD2_k127_4742684_4	523845.AQXV01000050_gene991	0.000194	46.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,23RB1@183939|Methanococci	183939|Methanococci	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMD2_k127_4776743_7	420247.Msm_1192	7.284e-45	167.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23NR8@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
MMD2_k127_4776743_8	351160.LRC241	1.67e-44	165.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
MMD2_k127_4776743_13	1183377.Py04_0340	1.412e-25	113.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,243SX@183968|Thermococci	183968|Thermococci	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
MMD2_k127_4776743_1	693661.Arcve_1203	1.286e-125	415.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
MMD2_k127_4776743_5	930945.SiRe_1932	4.862e-56	208.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
MMD2_k127_4776743_6	272562.CA_C2981	5.596e-54	198.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,36UK6@31979|Clostridiaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,2.7.7.71,5.4.2.8	ko:K00966,ko:K15669,ko:K16881	ko00051,ko00520,ko00540,ko01100,ko01110,ko01130,map00051,map00520,map00540,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818,R09772	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I
MMD2_k127_4776743_11	386456.JQKN01000001_gene2069	3.564e-30	127.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,23NZZ@183925|Methanobacteria	183925|Methanobacteria	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
MMD2_k127_4776743_12	877455.Metbo_1991	1.884e-27	115.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,23PPK@183925|Methanobacteria	183925|Methanobacteria	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMD2_k127_4776743_0	877455.Metbo_0592	2.317e-153	505.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,23NKN@183925|Methanobacteria	183925|Methanobacteria	E	RNase L inhibitor	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
MMD2_k127_4776743_3	309799.DICTH_0597	1.018e-65	235.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMD2_k127_4776743_16	536232.CLM_1410	2.451e-12	70.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia	186801|Clostridia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
MMD2_k127_4776743_9	932678.THERU_03960	6.513e-44	167.0	COG2410@1|root,COG2410@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF429)	-	-	-	ko:K09147	-	-	-	-	ko00000	-	-	-	DUF429
MMD2_k127_4776743_2	877455.Metbo_0098	1.545e-91	310.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,23NNK@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMD2_k127_4776743_10	1541065.JRFE01000014_gene1306	2.514e-41	158.0	2CCI4@1|root,30BPJ@2|Bacteria,1GAR7@1117|Cyanobacteria,3VMXW@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4776743_15	69319.XP_008547267.1	4.228e-15	81.0	COG5580@1|root,KOG2936@2759|Eukaryota,39P2Y@33154|Opisthokonta,3BFN4@33208|Metazoa,3CRH1@33213|Bilateria,41V1E@6656|Arthropoda,3SFS7@50557|Insecta,46JPK@7399|Hymenoptera	33208|Metazoa	O	Activator of Hsp90 ATPase, N-terminal	AHSA1	GO:0001671,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008047,GO:0008150,GO:0009987,GO:0030234,GO:0031072,GO:0032781,GO:0043085,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051087,GO:0051336,GO:0051345,GO:0051879,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0098772	-	-	-	-	-	-	-	-	-	-	AHSA1,Aha1_N
MMD2_k127_4776743_14	693661.Arcve_1550	1.673e-19	97.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y0SK@28890|Euryarchaeota,2476X@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMD2_k127_4776743_4	575590.HMPREF0156_01408	6.042e-62	222.0	COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes	976|Bacteroidetes	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMD2_k127_4777449_7	456442.Mboo_1621	2.364e-11	71.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2XZME@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4777449_4	529709.PYCH_16390	1.77e-40	160.0	COG0467@1|root,arCOG01171@2157|Archaea,2Y7MQ@28890|Euryarchaeota,243HH@183968|Thermococci	183968|Thermococci	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD2_k127_4777449_6	591019.Shell_0641	1.643e-13	76.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_4777449_1	748727.CLJU_c06740	4.848e-77	268.0	COG0017@1|root,COG0017@2|Bacteria,1UFEI@1239|Firmicutes,24EYB@186801|Clostridia,36GED@31979|Clostridiaceae	186801|Clostridia	J	tRNA synthetases class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
MMD2_k127_4777449_2	565033.GACE_2148	7.058e-58	209.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,246ZF@183980|Archaeoglobi	183980|Archaeoglobi	P	PFAM zinc iron permease	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
MMD2_k127_4777449_5	1278073.MYSTI_06533	2.151e-39	158.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,433WA@68525|delta/epsilon subdivisions,2X3U0@28221|Deltaproteobacteria,2YX3S@29|Myxococcales	28221|Deltaproteobacteria	J	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
MMD2_k127_4777449_8	203119.Cthe_0307	9.389e-11	66.0	COG4640@1|root,COG4640@2|Bacteria,1VB94@1239|Firmicutes,24N0R@186801|Clostridia,3WKKP@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234,zinc_ribbon_2
MMD2_k127_4777449_3	342949.PNA2_0513	2.633e-44	169.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
MMD2_k127_4777449_0	439481.Aboo_1394	1.145e-123	411.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,3F2HJ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	AAA domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
MMD2_k127_4806649_1	644966.Tmar_1670	5.426e-124	413.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,3WCDU@538999|Clostridiales incertae sedis	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMD2_k127_4806649_2	1423321.AS29_17845	6.602e-115	380.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HD08@91061|Bacilli,1ZPZV@1386|Bacillus	91061|Bacilli	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMD2_k127_4806649_0	688269.Theth_1986	5.644e-130	431.0	COG0156@1|root,COG0156@2|Bacteria,2GCC8@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMD2_k127_4806649_3	351160.RRC121	1.529e-70	249.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0095 Lipoate-protein ligase A	lpl	GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMD2_k127_4806649_6	759362.KVU_1794	2.627e-11	67.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMD2_k127_4806649_4	70601.3257954	3.067e-68	246.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,243J1@183968|Thermococci	183968|Thermococci	G	M42 glutamyl aminopeptidase	-	-	-	ko:K20608	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M42
MMD2_k127_4806649_5	1047013.AQSP01000094_gene23	2.697e-64	224.0	COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
MMD2_k127_4831576_2	693661.Arcve_0209	1.265e-06	51.0	COG1793@1|root,arCOG01347@2157|Archaea,2Y42Y@28890|Euryarchaeota	28890|Euryarchaeota	H	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
MMD2_k127_4831576_1	5664.LmjF.31.0560	1.862e-47	181.0	COG1577@1|root,KOG1511@2759|Eukaryota,3XRX8@5653|Kinetoplastida	5653|Kinetoplastida	I	mevalonate kinase	-	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMD2_k127_4831576_0	387631.Asulf_01604	4.103e-61	218.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,24680@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMD2_k127_4897922_0	243232.MJ_0326	1.036e-109	369.0	COG2252@1|root,arCOG02807@2157|Archaea,2XT7G@28890|Euryarchaeota,23QD0@183939|Methanococci	183939|Methanococci	F	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
MMD2_k127_4897922_2	406818.XBJ1_0645	1.526e-20	98.0	COG3545@1|root,COG3545@2|Bacteria,1RKTI@1224|Proteobacteria,1S66T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha beta hydrolase fold	ydeN	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
MMD2_k127_4967052_7	290397.Adeh_2142	1.193e-33	134.0	COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,42SNH@68525|delta/epsilon subdivisions,2WPQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EJ	PFAM Asparaginase	aspG	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMD2_k127_4967052_8	410359.Pcal_1637	6.257e-21	109.0	COG0419@1|root,arCOG00368@2157|Archaea	2157|Archaea	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
MMD2_k127_4967052_10	868131.MSWAN_0005	1.208e-16	94.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,23NJ6@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
MMD2_k127_4967052_6	456442.Mboo_0642	8.184e-43	168.0	arCOG08211@1|root,arCOG08211@2157|Archaea,2XW85@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4967052_11	1452536.JARE01000043_gene426	4.794e-16	86.0	COG0580@1|root,COG0580@2|Bacteria,2IPBW@201174|Actinobacteria,4FRWA@85023|Microbacteriaceae	201174|Actinobacteria	G	Major intrinsic protein	-	-	-	-	-	-	-	-	-	-	-	-	MIP
MMD2_k127_4967052_13	1500893.JQNB01000001_gene1536	4.46e-06	57.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1SG73@1236|Gammaproteobacteria,1X5NU@135614|Xanthomonadales	135614|Xanthomonadales	M	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta,He_PIG
MMD2_k127_4967052_14	317619.ANKN01000065_gene2865	0.0001166	53.0	COG0330@1|root,COG0330@2|Bacteria,1G06F@1117|Cyanobacteria,1MMJ6@1212|Prochloraceae	1117|Cyanobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMD2_k127_4967052_5	744872.Spica_1188	3.144e-59	209.0	COG0225@1|root,COG0225@2|Bacteria,2J5BJ@203691|Spirochaetes	203691|Spirochaetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMD2_k127_4967052_4	450851.PHZ_c0370	1.513e-63	234.0	COG0739@1|root,COG0739@2|Bacteria,1MXH6@1224|Proteobacteria,2U25J@28211|Alphaproteobacteria,2KH12@204458|Caulobacterales	204458|Caulobacterales	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMD2_k127_4967052_0	1121430.JMLG01000006_gene1745	3.716e-211	685.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,25ZY7@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD2_k127_4967052_2	1379698.RBG1_1C00001G0844	2.133e-94	327.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905,iNJ661.Rv2130c	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMD2_k127_4967052_12	1196083.SALWKB12_0330	6.133e-09	63.0	COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,2VQHR@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Ferritin, Dps family protein	bfr3	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
MMD2_k127_4967052_1	593750.Metfor_2226	2.658e-129	421.0	COG2899@1|root,arCOG05299@2157|Archaea,2Y4HF@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
MMD2_k127_4967052_15	7260.FBpp0239966	0.0001752	49.0	KOG3780@1|root,KOG3780@2759|Eukaryota,396T7@33154|Opisthokonta,3BAPI@33208|Metazoa,3D2UU@33213|Bilateria,41VSE@6656|Arthropoda,3SH0D@50557|Insecta,44X44@7147|Diptera,45RUZ@7214|Drosophilidae	33208|Metazoa	S	Arrestin (or S-antigen), C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Arrestin_C,Arrestin_N
MMD2_k127_4967052_3	1122915.AUGY01000001_gene7164	3.876e-66	236.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,4HNJ9@91061|Bacilli,26XB5@186822|Paenibacillaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD2_k127_4984330_0	926692.AZYG01000034_gene2372	9.707e-95	319.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,3WAED@53433|Halanaerobiales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
MMD2_k127_4984330_2	479434.Sthe_3509	1.611e-64	226.0	COG0807@1|root,COG0807@2|Bacteria,2G63D@200795|Chloroflexi,27XGC@189775|Thermomicrobia	189775|Thermomicrobia	H	GTP cyclohydrolase II	-	-	3.5.4.25,4.1.99.12	ko:K01497,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
MMD2_k127_4984330_7	930945.SiRe_1599	1.677e-32	138.0	COG0054@1|root,arCOG01323@2157|Archaea,2XQPW@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMD2_k127_4984330_5	573063.Metin_0470	2.39e-46	179.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,23Q11@183939|Methanococci	183939|Methanococci	H	TIGRFAM Riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMD2_k127_4984330_4	797210.Halxa_2283	4.207e-50	187.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,23U03@183963|Halobacteria	183963|Halobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	-	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
MMD2_k127_4984330_6	368408.Tpen_1546	9.02e-45	174.0	arCOG10919@1|root,arCOG10919@2157|Archaea	368408.Tpen_1546|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4984330_3	1121396.KB893053_gene2365	1.601e-51	192.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria,2MI7J@213118|Desulfobacterales	28221|Deltaproteobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
MMD2_k127_4984330_1	247490.KSU1_D0937	3.639e-87	298.0	COG0167@1|root,COG0167@2|Bacteria,2IX71@203682|Planctomycetes	203682|Planctomycetes	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.1,1.3.1.14	ko:K17723,ko:K17828	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01869,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
MMD2_k127_5055820_0	272844.PAB0154	5.404e-54	195.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_5055820_1	246969.TAM4_834	5.726e-21	105.0	COG1784@1|root,arCOG04469@2157|Archaea,2XSZ3@28890|Euryarchaeota,243G3@183968|Thermococci	183968|Thermococci	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K08971	-	-	-	-	ko00000	-	-	-	TctA
MMD2_k127_5245730_2	69014.TK1235	2.187e-39	154.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMD2_k127_5245730_1	351160.LRC287	3.732e-46	175.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
MMD2_k127_5245730_5	877455.Metbo_2371	1.251e-25	109.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23P26@183925|Methanobacteria	183925|Methanobacteria	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
MMD2_k127_5245730_3	456320.Mvol_1366	6.93e-29	120.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,23QTK@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
MMD2_k127_5245730_6	1114856.C496_14306	0.00041	49.0	COG1611@1|root,arCOG02431@2157|Archaea,2XZJU@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM SMF family protein	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
MMD2_k127_5245730_0	555779.Dthio_PD2054	2.04e-177	564.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2M8PC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMD2_k127_5245730_4	394503.Ccel_1151	1.737e-28	121.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36EH8@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD2_k127_5289521_1	330779.Saci_0758	2.456e-20	95.0	COG2007@1|root,arCOG04154@2157|Archaea,2XQUS@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM ribosomal protein S8E	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMD2_k127_5289521_0	665571.STHERM_c03280	1.688e-237	755.0	COG0143@1|root,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMD2_k127_5349486_0	720554.Clocl_3240	8.785e-38	155.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,3WGEC@541000|Ruminococcaceae	186801|Clostridia	L	HELICc2	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
MMD2_k127_5349486_1	96561.Dole_1742	4.887e-26	119.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42TFM@68525|delta/epsilon subdivisions,2WPBE@28221|Deltaproteobacteria,2MK7R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMD2_k127_5366481_1	748727.CLJU_c17600	9.636e-46	169.0	COG0716@1|root,COG0716@2|Bacteria,1V72U@1239|Firmicutes,24JNK@186801|Clostridia,36IZ8@31979|Clostridiaceae	186801|Clostridia	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3,Flavodoxin_5
MMD2_k127_5366481_0	368407.Memar_2156	2.496e-97	325.0	COG1266@1|root,arCOG02768@2157|Archaea,2Y1H1@28890|Euryarchaeota	28890|Euryarchaeota	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
MMD2_k127_5525896_2	593750.Metfor_0021	2.622e-36	148.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,2N9NG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_24,MarR
MMD2_k127_5525896_1	1220534.B655_2050	4.332e-39	154.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23P23@183925|Methanobacteria	183925|Methanobacteria	Q	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMD2_k127_5525896_0	644282.Deba_2699	1.611e-64	231.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMD2_k127_5573751_1	1042877.GQS_01595	1.693e-86	297.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMD2_k127_5573751_2	410358.Mlab_0358	8.932e-10	69.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMD2_k127_5573751_0	1220534.B655_1835	5.478e-138	460.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,23NN9@183925|Methanobacteria	183925|Methanobacteria	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
MMD2_k127_5579198_2	926549.KI421517_gene741	6.361e-06	48.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,47P5J@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMD2_k127_5579198_0	1304888.ATWF01000001_gene615	2.703e-164	531.0	COG0138@1|root,COG0138@2|Bacteria,2GFAQ@200930|Deferribacteres	200930|Deferribacteres	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
MMD2_k127_5579198_1	338966.Ppro_0868	3.109e-20	95.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2WKKK@28221|Deltaproteobacteria,43SA5@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	dmeF	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
MMD2_k127_5619027_4	186497.PF0172	7.517e-38	146.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2435F@183968|Thermococci	183968|Thermococci	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
MMD2_k127_5619027_12	1034769.KB910518_gene933	2.21e-06	58.0	COG1266@1|root,COG1266@2|Bacteria,1UYI9@1239|Firmicutes,4HRKM@91061|Bacilli,26U5Z@186822|Paenibacillaceae	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
MMD2_k127_5619027_11	1054217.TALC_00507	8.89e-09	58.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,241WR@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMD2_k127_5619027_10	1343739.PAP_00775	1.375e-12	72.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,244BP@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
MMD2_k127_5619027_5	304371.MCP_1738	5.287e-36	140.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMD2_k127_5619027_7	1230341.MJ3_10691	3.789e-29	126.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
MMD2_k127_5619027_2	589924.Ferp_2286	1.858e-38	149.0	COG1432@1|root,arCOG02408@2157|Archaea,2XX7V@28890|Euryarchaeota,246W0@183980|Archaeoglobi	183980|Archaeoglobi	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
MMD2_k127_5619027_13	604354.TSIB_1817	0.0008684	44.0	arCOG06624@1|root,arCOG06624@2157|Archaea,2Y56V@28890|Euryarchaeota,244UF@183968|Thermococci	183968|Thermococci	-	-	rpl41e	-	-	ko:K02928	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
MMD2_k127_5619027_6	368408.Tpen_0223	2.075e-35	143.0	COG0081@1|root,arCOG04289@2157|Archaea,2XQ8W@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMD2_k127_5619027_3	529709.PYCH_18200	3.386e-38	156.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,2434G@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s,Ribosomal_L10
MMD2_k127_5619027_9	224325.AF_1492	1.345e-19	91.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,2476N@183980|Archaeoglobi	183980|Archaeoglobi	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
MMD2_k127_5619027_1	1459636.NTE_01560	1.927e-50	186.0	COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMD2_k127_5619027_8	572546.Arcpr_0994	1.855e-21	95.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,246DE@183980|Archaeoglobi	183980|Archaeoglobi	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMD2_k127_5619027_0	693661.Arcve_1067	8.929e-177	563.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,246VQ@183980|Archaeoglobi	183980|Archaeoglobi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMD2_k127_5624492_2	1227484.C471_00445	1.657e-08	64.0	arCOG03129@1|root,arCOG03129@2157|Archaea,2XTF9@28890|Euryarchaeota,23T0X@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF2797)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2797
MMD2_k127_5624492_3	35754.JNYJ01000055_gene9994	1.654e-06	57.0	COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria,4DDJ1@85008|Micromonosporales	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD2_k127_5624492_1	694429.Pyrfu_1761	6.266e-12	76.0	COG2236@1|root,arCOG00040@2157|Archaea,2XQPX@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM phosphoribosyltransferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
MMD2_k127_5624492_0	565033.GACE_0683	1.105e-13	75.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,245TG@183980|Archaeoglobi	183980|Archaeoglobi	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMD2_k127_5627258_0	386456.JQKN01000002_gene2751	7.144e-70	241.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMD2_k127_5627258_2	593750.Metfor_0592	4.272e-10	63.0	arCOG06510@1|root,arCOG06510@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
MMD2_k127_5627258_1	1210908.HSB1_43070	4.382e-30	128.0	COG1474@1|root,arCOG00467@2157|Archaea,2XSUE@28890|Euryarchaeota,23SHX@183963|Halobacteria	183963|Halobacteria	L	Involved in regulation of DNA replication	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Cdc6_C
MMD2_k127_564301_1	1410609.JHVB01000001_gene1729	9.655e-99	331.0	COG2089@1|root,COG2089@2|Bacteria,2J662@203691|Spirochaetes	203691|Spirochaetes	M	Sialic acid synthase	spsE	-	2.5.1.101,2.5.1.56	ko:K01654,ko:K18430	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
MMD2_k127_564301_3	1354303.M917_0878	8.542e-38	150.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	arnC	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2
MMD2_k127_564301_2	763034.HMPREF9446_02410	3.994e-85	292.0	COG1861@1|root,COG1861@2|Bacteria,4NN3Q@976|Bacteroidetes,2G2VU@200643|Bacteroidia,4AW5V@815|Bacteroidaceae	976|Bacteroidetes	M	Cytidylyltransferase	-	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
MMD2_k127_564301_0	1317122.ATO12_22800	1.369e-148	476.0	COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,1HZDU@117743|Flavobacteriia,2YI4H@290174|Aquimarina	976|Bacteroidetes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMD2_k127_5665588_2	1071085.KK033115_gene2021	2.283e-30	128.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,23SMY@183963|Halobacteria	183963|Halobacteria	K	transcriptional regulator with C-terminal CBS domains	cbs8	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3,HTH_31
MMD2_k127_5665588_1	439481.Aboo_1240	4.421e-58	217.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,3F2I5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMD2_k127_5665588_0	634498.mru_1960	1.637e-59	219.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMD2_k127_5665588_3	1385512.N784_07460	5.058e-05	54.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,2Y9E9@289201|Pontibacillus	91061|Bacilli	T	Phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
MMD2_k127_5665588_4	1121438.JNJA01000001_gene2424	0.0006817	46.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MARF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
MMD2_k127_5730034_1	415426.Hbut_0031	2.237e-61	222.0	COG0513@1|root,arCOG00078@2157|Archaea,2XPRR@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMD2_k127_5730034_4	647113.Metok_0643	2.139e-34	136.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,23QVX@183939|Methanococci	183939|Methanococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMD2_k127_5730034_8	55529.EKX36024	9.303e-05	49.0	COG2118@1|root,KOG3431@2759|Eukaryota	2759|Eukaryota	U	regulation of protein import into mitochondrial outer membrane	PDCD5	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005539,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006950,GO:0006979,GO:0008047,GO:0008092,GO:0008150,GO:0008201,GO:0008219,GO:0008285,GO:0009636,GO:0009719,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010035,GO:0010421,GO:0010468,GO:0010604,GO:0010628,GO:0010638,GO:0010646,GO:0010647,GO:0010698,GO:0010821,GO:0010822,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012501,GO:0015631,GO:0019222,GO:0023051,GO:0023056,GO:0030162,GO:0030234,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0032386,GO:0032388,GO:0032879,GO:0032880,GO:0033043,GO:0033157,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0036473,GO:0036474,GO:0042127,GO:0042221,GO:0042493,GO:0042542,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043280,GO:0043281,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0048487,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051222,GO:0051223,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0051716,GO:0052547,GO:0052548,GO:0060255,GO:0060341,GO:0065007,GO:0065009,GO:0070201,GO:0070301,GO:0070848,GO:0070887,GO:0071236,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0080090,GO:0090087,GO:0090199,GO:0090200,GO:0090316,GO:0097159,GO:0097237,GO:0097367,GO:0097468,GO:0098772,GO:1901363,GO:1901681,GO:1901700,GO:1901701,GO:1903214,GO:1903332,GO:1903333,GO:1903533,GO:1903636,GO:1903638,GO:1903644,GO:1903645,GO:1903747,GO:1903749,GO:1903827,GO:1903829,GO:1903955,GO:1904589,GO:1904591,GO:1904951,GO:1905475,GO:1905477,GO:2000116,GO:2001056,GO:2001233,GO:2001235	1.1.1.169	ko:K00077,ko:K03354,ko:K03860,ko:K05389,ko:K06875	ko00563,ko00770,ko01100,ko01110,ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map00563,map00770,map01100,map01110,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00119,M00389	R02472,R05916	RC00726	ko00000,ko00001,ko00002,ko01000,ko03036,ko04040,ko04121	1.A.1.7	-	-	dsDNA_bind
MMD2_k127_5730034_10	410358.Mlab_1480	0.0003338	46.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMD2_k127_5730034_5	694429.Pyrfu_0981	7.342e-16	85.0	COG2097@1|root,arCOG04473@2157|Archaea,2XR1E@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
MMD2_k127_5730034_3	768679.TTX_1812	2.019e-34	140.0	COG1976@1|root,arCOG04176@2157|Archaea,2XQJ0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMD2_k127_5730034_7	269797.Mbar_A0460	3.566e-06	55.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y6W8@28890|Euryarchaeota,2NA5B@224756|Methanomicrobia	224756|Methanomicrobia	J	Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
MMD2_k127_5730034_6	647113.Metok_1386	5.049e-08	61.0	COG1730@1|root,arCOG01341@2157|Archaea,2XZ3V@28890|Euryarchaeota,23R6A@183939|Methanococci	183939|Methanococci	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMD2_k127_5730034_0	195522.BD01_0781	1.061e-84	299.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMD2_k127_5730034_9	401526.TcarDRAFT_2228	0.0001327	55.0	COG2755@1|root,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,4H4RY@909932|Negativicutes	909932|Negativicutes	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
MMD2_k127_5730034_2	69014.TK0060	1.493e-34	136.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,242JJ@183968|Thermococci	183968|Thermococci	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
MMD2_k127_5736729_1	1472418.BBJC01000004_gene1729	1.839e-10	69.0	COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	grp	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_5736729_0	224325.AF_1112	1.081e-29	122.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2462H@183980|Archaeoglobi	183980|Archaeoglobi	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	kae1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
MMD2_k127_5752689_2	410359.Pcal_0156	1.314e-29	123.0	COG2062@1|root,arCOG01992@2157|Archaea,2XRCX@28889|Crenarchaeota	28889|Crenarchaeota	T	TIGRFAM phosphohistidine phosphatase SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
MMD2_k127_5752689_1	1341151.ASZU01000004_gene320	3.405e-57	203.0	COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,4IQH5@91061|Bacilli,27DB5@186824|Thermoactinomycetaceae	91061|Bacilli	O	Peptide methionine sulfoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	PMSR
MMD2_k127_5752689_0	351160.RRC334	1.656e-109	359.0	COG0192@1|root,arCOG07444@2157|Archaea	2157|Archaea	H	S-adenosylmethionine synthetase, C-terminal domain	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
MMD2_k127_5800547_0	269797.Mbar_A3513	2.541e-124	411.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
MMD2_k127_5800547_1	383372.Rcas_3759	3.772e-09	68.0	COG1305@1|root,COG1305@2|Bacteria,2GABB@200795|Chloroflexi,374X3@32061|Chloroflexia	32061|Chloroflexia	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
MMD2_k127_5861286_0	743836.AYNA01000045_gene1250	1.827e-68	242.0	COG1652@1|root,COG2608@1|root,COG2836@1|root,COG4633@1|root,COG1652@2|Bacteria,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1PJEP@1224|Proteobacteria,2U3C2@28211|Alphaproteobacteria,36ZW5@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2,HMA,LysM
MMD2_k127_5861286_1	573061.Clocel_1523	1.967e-41	162.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMD2_k127_5876544_0	309799.DICTH_0757	7.031e-67	235.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
MMD2_k127_5876544_1	1047013.AQSP01000139_gene2393	8.119e-55	201.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
MMD2_k127_5876544_3	868131.MSWAN_0547	1.123e-05	50.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,23PVJ@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMD2_k127_5876544_2	379066.GAU_3141	1.116e-42	171.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG3946@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,COG3946@2|Bacteria,1ZUIV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GM	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
MMD2_k127_5945820_1	246969.TAM4_692	2.908e-102	346.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMD2_k127_5945820_2	370438.PTH_2676	9.28e-45	168.0	COG0288@1|root,COG0288@2|Bacteria,1V1YB@1239|Firmicutes,24GMG@186801|Clostridia,261GG@186807|Peptococcaceae	186801|Clostridia	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
MMD2_k127_5945820_0	1151117.AJLF01000001_gene1683	1.236e-184	595.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMD2_k127_5976408_0	224325.AF_1725	5.931e-68	247.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,246K0@183980|Archaeoglobi	2157|Archaea	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
MMD2_k127_5976408_1	760568.Desku_0982	6.088e-59	214.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,249R4@186801|Clostridia,260NY@186807|Peptococcaceae	186801|Clostridia	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
MMD2_k127_6011674_3	342949.PNA2_1270	3.125e-06	59.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y671@28890|Euryarchaeota,242WY@183968|Thermococci	183968|Thermococci	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_6011674_1	420247.Msm_0596	2.468e-08	65.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y780@28890|Euryarchaeota,23P2D@183925|Methanobacteria	183925|Methanobacteria	N	type II secretion	gspF1	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_6011674_0	1042877.GQS_06960	6.54e-93	326.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,242XB@183968|Thermococci	183968|Thermococci	U	type II secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Intein_splicing,LAGLIDADG_3,T2SSE
MMD2_k127_6011674_2	235909.GK1090	1.419e-06	58.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,4HHE6@91061|Bacilli,1WGE1@129337|Geobacillus	91061|Bacilli	S	Domain in cystathionine beta-synthase and other proteins.	ylbB	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD2_k127_6035361_1	868131.MSWAN_1973	1.625e-72	249.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,23NSM@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMD2_k127_6035361_0	391623.TERMP_01696	6.085e-231	729.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,243AQ@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing,LAGLIDADG_3
MMD2_k127_6035361_3	673860.AciM339_1303	5.531e-10	64.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,3F3EN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMD2_k127_6035361_2	304371.MCP_2288	3.396e-29	131.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2NAIS@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC-2	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMD2_k127_6054546_3	1996.JOFO01000079_gene5005	1.539e-06	60.0	COG5650@1|root,COG5650@2|Bacteria,2GN1J@201174|Actinobacteria,4EJA0@85012|Streptosporangiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
MMD2_k127_6054546_0	765177.Desmu_0349	4.938e-55	205.0	COG0463@1|root,arCOG00894@2157|Archaea,2XQ9U@28889|Crenarchaeota	28889|Crenarchaeota	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMD2_k127_6054546_2	373994.Riv7116_5541	3.493e-07	61.0	COG0467@1|root,COG0467@2|Bacteria,1G0KY@1117|Cyanobacteria,1HM2S@1161|Nostocales	1117|Cyanobacteria	F	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
MMD2_k127_6054546_1	644281.MFS40622_1613	1.882e-45	176.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,23Q6F@183939|Methanococci	183939|Methanococci	L	PFAM peptidase U62 modulator of DNA gyrase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_6073448_6	797209.ZOD2009_19558	3.373e-06	51.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,23T29@183963|Halobacteria	183963|Halobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMD2_k127_6073448_7	243233.MCA2799	5.534e-06	57.0	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1XGE8@135618|Methylococcales	135618|Methylococcales	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
MMD2_k127_6073448_3	523850.TON_1270	3.168e-45	172.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,242XX@183968|Thermococci	183968|Thermococci	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD2_k127_6073448_5	1056495.Calag_1477	1.408e-22	105.0	COG2178@1|root,arCOG04318@2157|Archaea,2XQKT@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
MMD2_k127_6073448_4	456442.Mboo_2282	1.277e-37	151.0	COG2340@1|root,COG3582@1|root,arCOG01769@2157|Archaea,arCOG03962@2157|Archaea,2Y7F2@28890|Euryarchaeota,2NBB2@224756|Methanomicrobia	224756|Methanomicrobia	S	AN1-like Zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
MMD2_k127_6073448_2	679926.Mpet_1841	1.482e-49	190.0	COG1253@1|root,arCOG00626@2157|Archaea,2XT1Z@28890|Euryarchaeota,2N962@224756|Methanomicrobia	224756|Methanomicrobia	S	CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
MMD2_k127_6073448_0	272844.PAB1982	3.001e-131	437.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,243SD@183968|Thermococci	183968|Thermococci	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	GO:0000166,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006195,GO:0006196,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009125,GO:0009126,GO:0009128,GO:0009150,GO:0009154,GO:0009158,GO:0009161,GO:0009166,GO:0009167,GO:0009169,GO:0009259,GO:0009261,GO:0009987,GO:0016208,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042301,GO:0042737,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
MMD2_k127_6073448_1	604354.TSIB_0548	1.393e-54	201.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2434J@183968|Thermococci	183968|Thermococci	J	Belongs to the eIF-2B alpha beta delta subunits family	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
MMD2_k127_6086375_1	410359.Pcal_0952	3.818e-31	135.0	COG2219@1|root,arCOG03013@2157|Archaea,2XQ8M@28889|Crenarchaeota	28889|Crenarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMD2_k127_6086375_0	673860.AciM339_0043	4.183e-85	292.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,3F2F3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMD2_k127_6086375_2	997346.HMPREF9374_3899	3.744e-07	57.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4HC58@91061|Bacilli,27BEN@186824|Thermoactinomycetaceae	91061|Bacilli	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
MMD2_k127_6122897_8	338963.Pcar_0549	6.909e-14	81.0	COG1704@1|root,COG1704@2|Bacteria,1RF5E@1224|Proteobacteria,42S8B@68525|delta/epsilon subdivisions,2WNYZ@28221|Deltaproteobacteria,43U7E@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
MMD2_k127_6122897_3	309799.DICTH_0756	1.848e-47	181.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
MMD2_k127_6122897_0	579137.Metvu_1306	2.16e-106	356.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD2_k127_6122897_12	1343739.PAP_09855	7.235e-05	57.0	COG1287@1|root,arCOG02044@2157|Archaea,2XU59@28890|Euryarchaeota,242T3@183968|Thermococci	183968|Thermococci	M	Oligosaccharyl transferase, STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
MMD2_k127_6122897_2	671065.MetMK1DRAFT_00029450	3.484e-58	220.0	COG1746@1|root,arCOG04249@2157|Archaea,2XQ3X@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMD2_k127_6122897_1	1457250.BBMO01000002_gene2671	1.501e-79	280.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,23SYR@183963|Halobacteria	183963|Halobacteria	J	exonuclease of the beta-lactamase fold involved in RNA processing	epf1	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
MMD2_k127_6122897_4	1077285.AGDG01000028_gene1440	2.615e-39	166.0	COG0475@1|root,COG0569@1|root,COG0475@2|Bacteria,COG0569@2|Bacteria,4NGF6@976|Bacteroidetes,2FNTX@200643|Bacteroidia,4AM9A@815|Bacteroidaceae	976|Bacteroidetes	P	PTS system, fructose-specific IIABC component K02768 K02769	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C
MMD2_k127_6122897_7	1122244.AUGF01000007_gene728	6.542e-25	116.0	COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,3NKVM@468|Moraxellaceae	1236|Gammaproteobacteria	P	Sodium/calcium exchanger protein	Z012_08255	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMD2_k127_6122897_9	1405.DJ92_3266	5.734e-12	71.0	COG1226@1|root,COG1226@2|Bacteria,1VCJJ@1239|Firmicutes,4HM5T@91061|Bacilli,1ZHZW@1386|Bacillus	91061|Bacilli	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
MMD2_k127_6122897_6	871968.DESME_01130	6.616e-26	117.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,263VD@186807|Peptococcaceae	186801|Clostridia	H	Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis	moeB	-	-	-	-	-	-	-	-	-	-	-	ThiF
MMD2_k127_6122897_5	580327.Tthe_2569	3.927e-35	142.0	COG0613@1|root,COG0613@2|Bacteria,1VCKE@1239|Firmicutes,25JY3@186801|Clostridia,42IIJ@68295|Thermoanaerobacterales	186801|Clostridia	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP
MMD2_k127_6122897_10	649747.HMPREF0083_03721	1.78e-11	77.0	COG1164@1|root,COG1164@2|Bacteria,1U8XY@1239|Firmicutes,4HEV8@91061|Bacilli,26TYN@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase family M3	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M2,Peptidase_M3
MMD2_k127_6122897_11	1230457.C476_00857	3.873e-08	55.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,23SHW@183963|Halobacteria	183963|Halobacteria	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMD2_k127_6139967_0	368408.Tpen_0817	1.427e-152	496.0	COG0008@1|root,arCOG00402@2157|Archaea,2XPVB@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMD2_k127_6139967_1	593750.Metfor_2529	8.659e-13	75.0	arCOG11331@1|root,arCOG11331@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
MMD2_k127_6190002_0	224325.AF_1255	7.07e-32	131.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,24625@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the ATCase OTCase family	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMD2_k127_6190002_2	246969.TAM4_1675	5.314e-21	100.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,242WQ@183968|Thermococci	183968|Thermococci	K	Segregation and condensation complex subunit ScpB	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMD2_k127_6190002_3	673860.AciM339_1341	5.403e-21	99.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,3F2TT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	adk2	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMD2_k127_6190002_1	436308.Nmar_1148	7.932e-31	132.0	COG1651@1|root,arCOG02868@2157|Archaea	2157|Archaea	O	COG1651 Protein-disulfide isomerase	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans,Thioredoxin_4
MMD2_k127_6190002_4	1343739.PAP_05770	6.968e-15	78.0	COG1695@1|root,arCOG00001@2157|Archaea,2Y6ET@28890|Euryarchaeota,244B9@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
MMD2_k127_6216161_0	641143.HMPREF9331_01413	7.233e-05	49.0	COG4260@1|root,COG4260@2|Bacteria,4NHXG@976|Bacteroidetes,1I0MU@117743|Flavobacteriia,1ERQM@1016|Capnocytophaga	976|Bacteroidetes	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,DZR,SHOCT
MMD2_k127_643829_8	1094980.Mpsy_1796	4.533e-15	79.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,2N98U@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMD2_k127_643829_3	370438.PTH_0565	6.566e-51	183.0	COG0432@1|root,COG0432@2|Bacteria,1V201@1239|Firmicutes,24FTY@186801|Clostridia,261SP@186807|Peptococcaceae	186801|Clostridia	J	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
MMD2_k127_643829_1	1151117.AJLF01000002_gene153	8.921e-87	308.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,243CJ@183968|Thermococci	183968|Thermococci	J	methylthiotransferase activity	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
MMD2_k127_643829_5	444158.MmarC6_1590	1.195e-44	175.0	COG0616@1|root,arCOG01311@2157|Archaea,2XTG8@28890|Euryarchaeota,23Q02@183939|Methanococci	183939|Methanococci	O	TIGRFAM signal peptide peptidase SppA, 36K type	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMD2_k127_643829_7	693661.Arcve_0687	1.601e-29	123.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,2471C@183980|Archaeoglobi	183980|Archaeoglobi	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMD2_k127_643829_4	589924.Ferp_1976	1.146e-49	188.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,245QI@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMD2_k127_643829_6	402880.MmarC5_1001	2.484e-38	149.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,23QSQ@183939|Methanococci	183939|Methanococci	J	SMART KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
MMD2_k127_643829_0	877455.Metbo_2374	2.699e-139	460.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,23NVB@183925|Methanobacteria	183925|Methanobacteria	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMD2_k127_643829_2	1104324.P186_0452	6.746e-83	287.0	COG1697@1|root,arCOG04143@2157|Archaea,2XPUM@28889|Crenarchaeota	28889|Crenarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
MMD2_k127_648859_1	1094980.Mpsy_1040	5.409e-39	156.0	COG2202@1|root,COG3221@1|root,arCOG01805@2157|Archaea,arCOG06515@2157|Archaea,2Y3GY@28890|Euryarchaeota,2NASN@224756|Methanomicrobia	224756|Methanomicrobia	PT	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Phosphonate-bd
MMD2_k127_648859_2	382464.ABSI01000020_gene194	4.977e-20	94.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Response_reg
MMD2_k127_648859_0	935948.KE386493_gene2429	9.222e-62	221.0	COG0426@1|root,COG0426@2|Bacteria,1V80E@1239|Firmicutes,24EX9@186801|Clostridia	186801|Clostridia	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD2_k127_648859_3	246969.TAM4_531	5.754e-06	49.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,243Q6@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
MMD2_k127_681234_0	386456.JQKN01000001_gene2273	6.991e-254	802.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,23NSP@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMD2_k127_681234_3	1151117.AJLF01000002_gene197	1.269e-59	214.0	COG2521@1|root,arCOG00054@2157|Archaea,2Y2KZ@28890|Euryarchaeota,243QH@183968|Thermococci	183968|Thermococci	Q	Spermine/spermidine synthase domain	-	-	-	ko:K06983	-	-	-	-	ko00000	-	-	-	Methyltransf_11,Methyltransf_25
MMD2_k127_681234_2	224324.aq_298	3.819e-146	476.0	COG0172@1|root,COG0172@2|Bacteria,2G3RF@200783|Aquificae	200783|Aquificae	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMD2_k127_681234_4	247490.KSU1_D0853	9.665e-56	217.0	COG5001@1|root,COG5001@2|Bacteria,2IY4F@203682|Planctomycetes	203682|Planctomycetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg
MMD2_k127_681234_1	1459636.NTE_00936	2.179e-157	510.0	COG0151@1|root,arCOG04415@2157|Archaea	2157|Archaea	F	Belongs to the GARS family	purD1	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C
MMD2_k127_717544_0	671143.DAMO_2168	1.121e-147	482.0	COG1892@1|root,COG1892@2|Bacteria	2|Bacteria	H	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppcA	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase_2
MMD2_k127_717544_5	1280692.AUJL01000020_gene1833	0.0001079	56.0	COG0484@1|root,COG0484@2|Bacteria,1V6FQ@1239|Firmicutes,25F3F@186801|Clostridia,36UX4@31979|Clostridiaceae	186801|Clostridia	O	Molecular chaperone, DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
MMD2_k127_717544_1	273068.TTE2332	1.075e-122	404.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,42F5T@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM malic	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
MMD2_k127_717544_2	639030.JHVA01000001_gene3341	7.817e-121	404.0	COG1027@1|root,COG1027@2|Bacteria,3Y3XS@57723|Acidobacteria,2JHYF@204432|Acidobacteriia	204432|Acidobacteriia	E	Fumarase C C-terminus	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMD2_k127_717544_3	573064.Mefer_1399	2.34e-119	391.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,23Q6E@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rad17,Rep_fac_C,RuvB_N
MMD2_k127_717544_4	439481.Aboo_0716	1.2e-33	138.0	COG0467@1|root,arCOG01171@2157|Archaea,2XTU3@28890|Euryarchaeota,3F31P@33867|unclassified Euryarchaeota	28890|Euryarchaeota	T	Rad51	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
MMD2_k127_80885_0	69014.TK1468	7.646e-58	214.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2435A@183968|Thermococci	183968|Thermococci	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMD2_k127_80885_3	439481.Aboo_0421	1.255e-09	63.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,3F2W3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
MMD2_k127_80885_2	224325.AF_0462	1.656e-21	105.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,246WJ@183980|Archaeoglobi	183980|Archaeoglobi	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
MMD2_k127_80885_1	1220534.B655_2010	4.243e-46	186.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMD2_k127_82323_7	694440.JOMF01000005_gene71	4.475e-12	73.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
MMD2_k127_82323_5	339860.Msp_1371	8.501e-20	94.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,23P69@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
MMD2_k127_82323_3	573064.Mefer_1265	2.759e-77	271.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,23Q5X@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
MMD2_k127_82323_1	1056495.Calag_1500	5.829e-214	694.0	COG0086@1|root,arCOG04257@2157|Archaea,2XPT5@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMD2_k127_82323_0	69014.TK1083	2.425e-223	708.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,24327@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMD2_k127_82323_2	647113.Metok_0489	2.781e-145	475.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,23Q3N@183939|Methanococci	183939|Methanococci	K	Belongs to the RNA polymerase beta chain family	rpoB2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
MMD2_k127_82323_6	195522.BD01_0186	6.209e-16	81.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,244K3@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMD2_k127_82323_4	243232.MJ_1575	3.747e-47	176.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,23QH2@183939|Methanococci	183939|Methanococci	F	Catalyzes the synthesis of GMP from XMP	guaAA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMD2_k127_82323_8	67593.Physo136510	2.155e-07	61.0	COG1590@1|root,COG2520@1|root,KOG0379@1|root,KOG0379@2759|Eukaryota,KOG1227@2759|Eukaryota,KOG1228@2759|Eukaryota,3QAZC@4776|Peronosporales	4776|Peronosporales	J	Methyltransferase TYW3	-	-	2.1.1.282	ko:K15450	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Kelch_4,Met_10,TYW3
MMD2_k127_84428_0	1485545.JQLW01000006_gene283	2.485e-10	73.0	COG0457@1|root,COG3391@1|root,COG4783@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,COG4783@2|Bacteria,1R1XY@1224|Proteobacteria	1224|Proteobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_2,TPR_8
MMD2_k127_884097_1	386456.JQKN01000001_gene2338	4.982e-13	77.0	COG0500@1|root,arCOG04347@2157|Archaea,2Y7W1@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMD2_k127_884097_2	1122197.ATWI01000010_gene978	1.738e-05	57.0	COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,464KM@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMD2_k127_884097_0	693661.Arcve_1800	5.497e-47	178.0	COG0392@1|root,arCOG00897@2157|Archaea,2XT65@28890|Euryarchaeota,246JX@183980|Archaeoglobi	183980|Archaeoglobi	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	Glycos_transf_2,LPG_synthase_TM
MMD2_k127_944085_2	1392491.JIAE01000001_gene1046	3.497e-06	51.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,3WI84@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.132,1.1.1.136,1.1.1.22,1.1.1.336	ko:K00012,ko:K00066,ko:K02472,ko:K02474,ko:K13015	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,ko05111,map00040,map00051,map00053,map00520,map01100,map02020,map05111	M00014,M00129,M00361,M00362	R00286,R00421,R00880,R03317,R06894	RC00291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
MMD2_k127_944085_0	246196.MSMEI_5796	7.354e-67	239.0	COG0451@1|root,COG0451@2|Bacteria,2I9T0@201174|Actinobacteria,237DX@1762|Mycobacteriaceae	201174|Actinobacteria	GM	Involved in galactofuranosyl biosynthesis converts UDO-GlcP to UDP-GalP catalytic activity UDP- glucopyranose UDP-galactopyranose	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMD2_k127_944085_1	426368.MmarC7_0044	4.345e-32	139.0	COG5427@1|root,arCOG00563@2157|Archaea,2Y2Q0@28890|Euryarchaeota,23RIP@183939|Methanococci	183939|Methanococci	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_964727_11	573063.Metin_0632	2.677e-20	100.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,23QU0@183939|Methanococci	183939|Methanococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMD2_k127_964727_10	1183377.Py04_1703	2.206e-26	113.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24405@183968|Thermococci	183968|Thermococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMD2_k127_964727_4	391623.TERMP_00094	1.223e-71	249.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,242MT@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
MMD2_k127_964727_15	9483.ENSCJAP00000041565	1.278e-07	59.0	COG0089@1|root,KOG1751@2759|Eukaryota,3A1K9@33154|Opisthokonta,3BJFK@33208|Metazoa,3CZJC@33213|Bilateria,486FA@7711|Chordata,496QE@7742|Vertebrata,3J6QI@40674|Mammalia,35APV@314146|Euarchontoglires,4M7XE@9443|Primates	33208|Metazoa	J	Ribosomal protein L23, N-terminal domain	RPL23A	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02893	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23,Ribosomal_L23eN
MMD2_k127_964727_6	579137.Metvu_1669	9.031e-47	178.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23QJT@183939|Methanococci	183939|Methanococci	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMD2_k127_964727_2	386456.JQKN01000001_gene1763	1.245e-76	267.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,23NMA@183925|Methanobacteria	183925|Methanobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMD2_k127_964727_12	768672.Desfe_1260	1.562e-19	96.0	COG1102@1|root,arCOG01037@2157|Archaea,2XQ8J@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMD2_k127_964727_18	420247.Msm_0733	5.458e-05	49.0	COG2163@1|root,arCOG04167@2157|Archaea,2XYTF@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L14e
MMD2_k127_964727_5	439481.Aboo_1494	1.209e-61	222.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,3F354@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
MMD2_k127_964727_14	679926.Mpet_2604	9.039e-09	64.0	arCOG02452@1|root,arCOG02452@2157|Archaea,2XZME@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0467 RecA-superfamily ATPases implicated in signal transduction	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_964727_3	1121335.Clst_1293	1.014e-72	265.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,3WGMK@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
MMD2_k127_964727_13	693746.OBV_08660	4.569e-14	72.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,2N7GS@216572|Oscillospiraceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
MMD2_k127_964727_0	1321778.HMPREF1982_03953	8.588e-164	524.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,267NA@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMD2_k127_964727_9	529709.PYCH_18170	5.24e-33	135.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2441S@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
MMD2_k127_964727_17	877455.Metbo_2248	4.046e-05	47.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y0DZ@28890|Euryarchaeota	28890|Euryarchaeota	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
MMD2_k127_964727_1	644281.MFS40622_1157	6.049e-111	370.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23Q86@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMD2_k127_964727_8	713586.KB900536_gene1346	8.463e-43	162.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
MMD2_k127_964727_16	1183377.Py04_1272	3.151e-06	52.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,244ED@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
MMD2_k127_964727_7	391623.TERMP_00391	1.039e-44	172.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,242SR@183968|Thermococci	183968|Thermococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMD2_k127_979314_1	406327.Mevan_1180	3.47e-46	168.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
MMD2_k127_979314_0	573063.Metin_0043	4.111e-153	493.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
MMD2_k127_979314_6	523845.AQXV01000049_gene951	1.275e-09	69.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
MMD2_k127_979314_2	386456.JQKN01000001_gene2034	3.176e-24	114.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,23NMS@183925|Methanobacteria	183925|Methanobacteria	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMD2_k127_979314_4	880072.Desac_2016	3.686e-14	78.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MRPV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
MMD2_k127_979314_3	1379281.AVAG01000079_gene1546	1.796e-17	87.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MBI7@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Amino acid-binding ACT	-	-	-	-	-	-	-	-	-	-	-	-	ACT
MMD2_k127_979314_5	269797.Mbar_A1592	2.336e-13	74.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,2N9YQ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
MMD2_k127_979314_7	1131812.JQMS01000001_gene2356	3.74e-06	60.0	COG4932@1|root,COG5184@1|root,COG4932@2|Bacteria,COG5184@2|Bacteria,4NK5Z@976|Bacteroidetes,1IKKZ@117743|Flavobacteriia,2NTPP@237|Flavobacterium	976|Bacteroidetes	DMZ	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494
MMD2_k127_986063_0	70601.3256402	1.985e-202	644.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,242UA@183968|Thermococci	183968|Thermococci	O	Belongs to the TCP-1 chaperonin family	ths	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMD2_k127_986063_9	351607.Acel_0019	8.852e-36	147.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EX2B@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
MMD2_k127_986063_15	273116.14325170	0.0004087	50.0	arCOG01806@1|root,arCOG01806@2157|Archaea,2XWT7@28890|Euryarchaeota,2428G@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_986063_14	1206732.BAGD01000044_gene1541	5.325e-11	70.0	COG1522@1|root,COG1522@2|Bacteria,2H7NM@201174|Actinobacteria,4G11R@85025|Nocardiaceae	201174|Actinobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_986063_10	768679.TTX_0289	1.233e-33	145.0	COG0311@1|root,arCOG00034@2157|Archaea,2XQEU@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
MMD2_k127_986063_8	436308.Nmar_0969	1.716e-41	155.0	arCOG05276@1|root,arCOG05276@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_excise
MMD2_k127_986063_1	1089553.Tph_c00140	8.384e-123	400.0	COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,42EVS@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
MMD2_k127_986063_3	439481.Aboo_0917	8.016e-100	341.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,3F2HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMD2_k127_986063_13	1450694.BTS2_2533	3.569e-12	74.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,4HE7X@91061|Bacilli,1ZB95@1386|Bacillus	91061|Bacilli	S	Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool	ppaX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMD2_k127_986063_11	65393.PCC7424_4923	3.07e-33	133.0	COG2510@1|root,COG2510@2|Bacteria,1GMB6@1117|Cyanobacteria,3KK1P@43988|Cyanothece	1117|Cyanobacteria	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
MMD2_k127_986063_6	399550.Smar_1245	2.651e-65	231.0	COG0020@1|root,arCOG01532@2157|Archaea,2XPUG@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.89	ko:K00806,ko:K15888	ko00900,ko01110,map00900,map01110	-	R06447,R09730	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
MMD2_k127_986063_2	1094980.Mpsy_1916	5.057e-108	360.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9G6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMD2_k127_986063_4	565033.GACE_1114	3.612e-91	314.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,245ZX@183980|Archaeoglobi	183980|Archaeoglobi	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD2_k127_986063_12	1365176.N186_05050	8.943e-20	94.0	COG2433@1|root,arCOG04219@2157|Archaea,2XPME@28889|Crenarchaeota	28889|Crenarchaeota	S	DUF460 domain containing protein	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
MMD2_k127_986063_5	1365176.N186_07130	1.415e-86	303.0	COG0531@1|root,arCOG00009@2157|Archaea,2XRZZ@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
MMD2_k127_986063_7	368407.Memar_0905	5.06e-43	159.0	arCOG03001@1|root,arCOG03001@2157|Archaea,2Y6YJ@28890|Euryarchaeota,2NATB@224756|Methanomicrobia	224756|Methanomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
## 840 queries scanned
## Total time (seconds): 112.80670022964478
## Rate: 7.45 q/s