## Tue Nov 12 10:14:20 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/4635/M/MMD2_bin.38.fa -m mmseqs --itype genome -o MMD2_bin.38 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/bins_4635/MMD2_bin.38 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMD2_k127_100621_2	436308.Nmar_1499	2.223e-68	239.0	COG0338@1|root,arCOG03416@2157|Archaea,41SHH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	PFAM D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMD2_k127_100621_4	589924.Ferp_0431	1.358e-22	106.0	COG5549@1|root,arCOG04994@2157|Archaea,2Y4E9@28890|Euryarchaeota	28890|Euryarchaeota	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_100621_5	1150864.MILUP08_44719	5.36e-18	91.0	COG4894@1|root,COG4894@2|Bacteria,2GKWI@201174|Actinobacteria,4DDQF@85008|Micromonosporales	201174|Actinobacteria	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
MMD2_k127_100621_3	221288.JH992901_gene3494	3.525e-24	113.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	CAP,Laminin_G_3
MMD2_k127_100621_6	1124780.ANNU01000044_gene475	6.631e-14	82.0	COG4974@1|root,COG4974@2|Bacteria,4NGB5@976|Bacteroidetes,47PJP@768503|Cytophagia	976|Bacteroidetes	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
MMD2_k127_100621_0	436308.Nmar_1120	1.876e-289	919.0	COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD2_k127_100621_1	1151117.AJLF01000002_gene153	1.347e-82	287.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,243CJ@183968|Thermococci	183968|Thermococci	J	methylthiotransferase activity	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
MMD2_k127_1024324_0	387631.Asulf_00923	1.721e-18	99.0	COG1520@1|root,arCOG02479@2157|Archaea,2Y7PV@28890|Euryarchaeota	28890|Euryarchaeota	S	PQQ enzyme repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
MMD2_k127_1189245_18	720554.Clocl_2280	3.599e-13	79.0	COG3815@1|root,COG3815@2|Bacteria,1VGBP@1239|Firmicutes,25K7A@186801|Clostridia,3WP3Q@541000|Ruminococcaceae	186801|Clostridia	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
MMD2_k127_1189245_19	673860.AciM339_1041	3.385e-09	61.0	arCOG03672@1|root,arCOG08126@1|root,arCOG03672@2157|Archaea,arCOG08126@2157|Archaea,2Y73H@28890|Euryarchaeota,3F3BZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
MMD2_k127_1189245_20	1158318.ATXC01000002_gene1596	2.135e-08	63.0	COG3743@1|root,COG3743@2|Bacteria,2G52I@200783|Aquificae	200783|Aquificae	S	Domain of unknown function (DUF4332)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4332
MMD2_k127_1189245_4	368408.Tpen_1239	6.218e-63	226.0	COG1814@1|root,arCOG01091@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
MMD2_k127_1189245_11	386456.JQKN01000005_gene429	1.076e-32	131.0	COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
MMD2_k127_1189245_16	272560.BPSS2309	4.283e-16	85.0	COG1670@1|root,COG1670@2|Bacteria,1N5GX@1224|Proteobacteria,2VWRJ@28216|Betaproteobacteria,1K8BV@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
MMD2_k127_1189245_25	453591.Igni_1396	0.0002798	45.0	arCOG04323@1|root,arCOG04323@2157|Archaea,2XQVX@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1189245_3	224325.AF_0364	2.175e-88	321.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245PD@183980|Archaeoglobi	183980|Archaeoglobi	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C
MMD2_k127_1189245_21	1006006.Mcup_1202	2.532e-07	59.0	COG1591@1|root,arCOG00919@2157|Archaea	2157|Archaea	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	-	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
MMD2_k127_1189245_7	1379698.RBG1_1C00001G1666	3.13e-57	207.0	COG1136@1|root,COG1136@2|Bacteria,2NPA8@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD2_k127_1189245_22	397948.Cmaq_1384	7.316e-07	62.0	COG0577@1|root,arCOG02312@2157|Archaea,2XQ0N@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD2_k127_1189245_24	1122602.ATXP01000001_gene1168	6.188e-05	56.0	COG0577@1|root,COG0577@2|Bacteria,2HSU1@201174|Actinobacteria,1W7RQ@1268|Micrococcaceae	201174|Actinobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD2_k127_1189245_14	985053.VMUT_0604	6.661e-19	96.0	arCOG03727@1|root,arCOG03727@2157|Archaea	2157|Archaea	-	-	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	Mrr_cat,NERD
MMD2_k127_1189245_12	386456.JQKN01000005_gene515	1.99e-31	132.0	COG0746@1|root,arCOG01872@2157|Archaea,2XWJR@28890|Euryarchaeota,23PNI@183925|Methanobacteria	183925|Methanobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
MMD2_k127_1189245_8	1094980.Mpsy_2168	5.073e-44	169.0	COG0455@1|root,arCOG00589@2157|Archaea	2157|Archaea	D	COG0455 ATPases involved in chromosome partitioning	-	-	-	ko:K03496,ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
MMD2_k127_1189245_15	1094980.Mpsy_2169	1.861e-18	89.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1189245_23	633148.Tagg_0901	1.625e-06	53.0	COG3432@1|root,arCOG01055@2157|Archaea,2XSK9@28889|Crenarchaeota	28889|Crenarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMD2_k127_1189245_0	694429.Pyrfu_0229	1.12e-194	615.0	COG5256@1|root,arCOG01561@2157|Archaea,2XPNT@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMD2_k127_1189245_6	304371.MCP_2179	3.74e-58	208.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota,2NAVE@224756|Methanomicrobia	224756|Methanomicrobia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
MMD2_k127_1189245_5	391623.TERMP_00349	4.131e-60	212.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2440M@183968|Thermococci	183968|Thermococci	O	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
MMD2_k127_1189245_1	368408.Tpen_0002	1.903e-132	431.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
MMD2_k127_1189245_10	1499689.CCNN01000014_gene3279	4.045e-40	154.0	COG1670@1|root,COG1670@2|Bacteria,1V4IY@1239|Firmicutes,24FWK@186801|Clostridia,36IY5@31979|Clostridiaceae	186801|Clostridia	J	guanosine monophosphate synthetase GuaA K01951	guaA3	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMD2_k127_1189245_17	1294142.CINTURNW_1192	1.574e-13	75.0	2DMPW@1|root,32SY6@2|Bacteria,1VAXG@1239|Firmicutes,24MNR@186801|Clostridia,36KF1@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
MMD2_k127_1189245_13	272844.PAB0190	1.951e-28	123.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
MMD2_k127_1189245_9	1183377.Py04_0712	8.231e-44	166.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,242YZ@183968|Thermococci	183968|Thermococci	C	Indolepyruvate ferredoxin oxidoreductase subunit	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
MMD2_k127_1189245_2	224325.AF_1489	2.355e-107	359.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,246UD@183980|Archaeoglobi	183980|Archaeoglobi	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
MMD2_k127_1197_36	415426.Hbut_0412	7.043e-13	73.0	COG5625@1|root,arCOG04189@2157|Archaea	2157|Archaea	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1197_1	1123371.ATXH01000001_gene1224	4.83e-168	539.0	COG0499@1|root,COG0499@2|Bacteria,2GGXJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMD2_k127_1197_5	1041930.Mtc_1045	2.89e-123	405.0	arCOG01186@1|root,arCOG01186@2157|Archaea	2157|Archaea	G	Mn2 dependent serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMD2_k127_1197_21	515635.Dtur_0654	1.99e-32	130.0	COG1833@1|root,COG1833@2|Bacteria	2|Bacteria	J	Belongs to the SfsA family	sfsA	-	6.1.1.21	ko:K01892,ko:K06206	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DUF123,SfsA
MMD2_k127_1197_15	351160.RRC41	2.987e-49	181.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
MMD2_k127_1197_8	572546.Arcpr_1361	5.088e-100	336.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,245SD@183980|Archaeoglobi	183980|Archaeoglobi	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMD2_k127_1197_10	1220534.B655_1959	5.592e-81	277.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23NJ7@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L4	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMD2_k127_1197_26	604354.TSIB_0290	1.493e-25	108.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,244AA@183968|Thermococci	183968|Thermococci	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMD2_k127_1197_12	374847.Kcr_1490	5.516e-72	250.0	COG0090@1|root,arCOG04067@2157|Archaea	2157|Archaea	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
MMD2_k127_1197_16	529709.PYCH_01410	3.165e-48	175.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,24405@183968|Thermococci	183968|Thermococci	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMD2_k127_1197_31	591019.Shell_1488	1.466e-17	88.0	arCOG05517@1|root,arCOG05517@2157|Archaea,2XSGW@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1197_33	644281.MFS40622_0926	1.622e-13	74.0	COG1998@1|root,arCOG04183@2157|Archaea,2Y0HV@28890|Euryarchaeota,23R7R@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMD2_k127_1197_35	573064.Mefer_0875	4.221e-13	73.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,23R5Q@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
MMD2_k127_1197_23	186497.PF0254	1.091e-28	121.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2440N@183968|Thermococci	183968|Thermococci	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
MMD2_k127_1197_32	1183377.Py04_0406	6.748e-15	76.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,244KC@183968|Thermococci	183968|Thermococci	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
MMD2_k127_1197_13	1459636.NTE_01705	9.874e-65	226.0	COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
MMD2_k127_1197_29	591019.Shell_1635	3.776e-18	89.0	COG1412@1|root,arCOG04312@2157|Archaea,2XR40@28889|Crenarchaeota	28889|Crenarchaeota	V	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	Fcf1,PIN
MMD2_k127_1197_2	1183377.Py04_1598	3.78e-160	514.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,242PH@183968|Thermococci	183968|Thermococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
MMD2_k127_1197_20	572546.Arcpr_0876	6.427e-33	133.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,2470Y@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMD2_k127_1197_37	933801.Ahos_0073	9.166e-09	67.0	COG0477@1|root,arCOG00131@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD2_k127_1197_4	1041930.Mtc_0381	1.729e-148	488.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
MMD2_k127_1197_6	373903.Hore_04150	1.042e-117	396.0	COG2317@1|root,COG2317@2|Bacteria,1TPS6@1239|Firmicutes,249NK@186801|Clostridia	186801|Clostridia	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
MMD2_k127_1197_14	1131462.DCF50_p1651	4.812e-62	221.0	COG1418@1|root,COG1418@2|Bacteria,1V2RJ@1239|Firmicutes,25B26@186801|Clostridia	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMD2_k127_1197_9	523845.AQXV01000015_gene369	9.257e-92	315.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,23QFZ@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
MMD2_k127_1197_18	1343739.PAP_03695	2.961e-39	150.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2445F@183968|Thermococci	183968|Thermococci	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
MMD2_k127_1197_11	1459636.NTE_01027	4.185e-80	282.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMD2_k127_1197_17	673860.AciM339_0348	1.398e-43	175.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y719@28890|Euryarchaeota,3F34W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD2_k127_1197_19	633148.Tagg_1153	1.068e-38	152.0	COG0125@1|root,arCOG01891@2157|Archaea,2XQB7@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM thymidylate kinase	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMD2_k127_1197_34	1365176.N186_04575	3.606e-13	74.0	COG1645@1|root,arCOG00578@2157|Archaea,2XR3I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sjogrens syndrome scleroderma autoantigen 1	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
MMD2_k127_1197_28	273063.STK_04605	6.807e-22	98.0	COG1698@1|root,arCOG04308@2157|Archaea,2XQVN@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMD2_k127_1197_22	459349.CLOAM1816	6.989e-30	121.0	COG1917@1|root,COG1917@2|Bacteria,2NQ91@2323|unclassified Bacteria	2|Bacteria	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD2_k127_1197_0	555079.Toce_2249	4.753e-183	583.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,42FH5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM FAD dependent oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
MMD2_k127_1197_30	702450.CUW_0708	6.712e-18	93.0	COG1594@1|root,COG1594@2|Bacteria,1UHVH@1239|Firmicutes	1239|Firmicutes	K	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1197_24	410359.Pcal_2021	1.822e-28	121.0	arCOG05710@1|root,arCOG05710@2157|Archaea,2XQWV@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1197_7	178306.PAE3638	7.513e-111	368.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XSQD@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART zinc finger, RanBP2-type	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,UPF0547,zinc_ribbon_2
MMD2_k127_1197_3	1459636.NTE_02878	7.089e-155	505.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMD2_k127_1197_39	573.JG24_17555	8.996e-07	57.0	299ND@1|root,2ZWQQ@2|Bacteria,1NQCC@1224|Proteobacteria,1SPBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
MMD2_k127_1197_40	411461.DORFOR_01218	0.0004458	49.0	COG4640@1|root,COG4640@2|Bacteria,1VKSN@1239|Firmicutes,24V67@186801|Clostridia	186801|Clostridia	S	Interferon-induced transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CD225,zinc_ribbon_2
MMD2_k127_1197_25	634497.HAH_0228	2.846e-27	117.0	COG1714@1|root,arCOG03633@2157|Archaea,2XYB1@28890|Euryarchaeota,23WIB@183963|Halobacteria	183963|Halobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
MMD2_k127_1197_27	509191.AEDB02000017_gene199	6.676e-24	104.0	COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,3WH12@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the LDH MDH superfamily. LDH family	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
MMD2_k127_1225240_2	458233.MCCL_1900	1.671e-73	257.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,4GX3M@90964|Staphylococcaceae	91061|Bacilli	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMD2_k127_1225240_3	69014.TK2169	6.999e-72	260.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,24370@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_1225240_5	370438.PTH_1159	2.792e-27	126.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_1225240_10	634498.mru_0698	6.462e-10	68.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y782@28890|Euryarchaeota,23P3B@183925|Methanobacteria	183925|Methanobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
MMD2_k127_1225240_0	644281.MFS40622_0005	7.013e-196	628.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,23Q05@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMD2_k127_1225240_1	368408.Tpen_0341	5.348e-192	609.0	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMD2_k127_1225240_6	374847.Kcr_1302	6.505e-25	111.0	COG1394@1|root,arCOG04101@2157|Archaea	2157|Archaea	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	iAF692.Mbar_A0384	ATP-synt_D
MMD2_k127_1225240_7	373903.Hore_19450	5.059e-13	80.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia	186801|Clostridia	C	Archaeal vacuolar-type H -ATPase subunit C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMD2_k127_1225240_9	441768.ACL_1172	5.04e-10	67.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMD2_k127_1225240_4	368408.Tpen_0337	6.481e-46	188.0	COG1269@1|root,arCOG04138@2157|Archaea,2XQ7V@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMD2_k127_1225240_13	1121363.KB902193_gene2658	0.0003288	48.0	COG0640@1|root,COG0640@2|Bacteria,2IKP4@201174|Actinobacteria,22NHQ@1653|Corynebacteriaceae	201174|Actinobacteria	K	transcriptional	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
MMD2_k127_1225240_8	399550.Smar_0462	1.53e-10	69.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMD2_k127_1225240_11	273068.TTE1224	3.626e-07	54.0	COG1906@1|root,COG1906@2|Bacteria,1V5AX@1239|Firmicutes,24JFK@186801|Clostridia,42HAZ@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
MMD2_k127_1370936_2	1459636.NTE_02630	1.034e-51	187.0	COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_1370936_1	304371.MCP_2480	5.148e-116	390.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,2N98P@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM glutamine synthetase, type I	glnA-2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMD2_k127_1370936_0	415426.Hbut_0903	2.52e-171	560.0	COG1241@1|root,arCOG00439@2157|Archaea,2XQ2Z@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the MCM family	-	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Intein_splicing,MCM,MCM_N,MCM_OB
MMD2_k127_1370936_4	69293.ENSGACP00000021071	4.92e-07	59.0	COG5093@1|root,KOG4071@2759|Eukaryota,39ABE@33154|Opisthokonta,3BFYM@33208|Metazoa,3D066@33213|Bilateria,487V2@7711|Chordata,491UI@7742|Vertebrata,49XW2@7898|Actinopterygii	33208|Metazoa	L	DNA replication complex GINS protein	GINS2	GO:0000228,GO:0000278,GO:0000724,GO:0000725,GO:0000727,GO:0000811,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006271,GO:0006281,GO:0006302,GO:0006310,GO:0006323,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007346,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0016043,GO:0019219,GO:0019222,GO:0022402,GO:0022616,GO:0030261,GO:0031261,GO:0031298,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032784,GO:0032991,GO:0032993,GO:0033260,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044786,GO:0045787,GO:0045931,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0051726,GO:0060255,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090068,GO:0090304,GO:1900087,GO:1901360,GO:1901576,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902292,GO:1902315,GO:1902806,GO:1902808,GO:1902969,GO:1902975,GO:1903047,GO:1903506,GO:2000045,GO:2000112,GO:2001141	-	ko:K10733	-	M00286	-	-	ko00000,ko00002,ko03032	-	-	-	Sld5
MMD2_k127_1370936_3	1536773.R70331_13780	8.878e-37	140.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,4HAEI@91061|Bacilli,26RN2@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMD2_k127_1439220_2	56110.Oscil6304_4716	2.393e-23	102.0	COG0338@1|root,COG0338@2|Bacteria,1G0BF@1117|Cyanobacteria,1H9B8@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMD2_k127_1439220_1	771875.Ferpe_1310	3.936e-78	269.0	COG0778@1|root,COG0778@2|Bacteria,2GCST@200918|Thermotogae	200918|Thermotogae	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMD2_k127_1439220_0	439481.Aboo_0292	1.149e-95	322.0	COG3294@1|root,arCOG04230@2157|Archaea,2XURZ@28890|Euryarchaeota,3F2ZC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
MMD2_k127_1439220_3	1223523.H340_14456	0.0003489	51.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
MMD2_k127_1583325_0	386456.JQKN01000008_gene1391	1.154e-63	228.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
MMD2_k127_1583325_9	1459636.NTE_02680	2.714e-08	59.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMD2_k127_1583325_1	1151117.AJLF01000001_gene1528	2.076e-30	126.0	COG0716@1|root,arCOG00519@2157|Archaea,2XZ4A@28890|Euryarchaeota,24470@183968|Thermococci	183968|Thermococci	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
MMD2_k127_1583325_4	195522.BD01_1801	7.632e-17	89.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y1FZ@28890|Euryarchaeota,243EZ@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMD2_k127_1583325_10	1343739.PAP_03055	4.2e-08	63.0	COG1522@1|root,arCOG01581@2157|Archaea,2Y3C6@28890|Euryarchaeota,2442S@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD2_k127_1583325_6	1220534.B655_2352	9.798e-13	74.0	COG1714@1|root,arCOG03633@2157|Archaea,2Y140@28890|Euryarchaeota,23P6J@183925|Methanobacteria	183925|Methanobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
MMD2_k127_1583325_8	523845.AQXV01000049_gene951	3.025e-09	66.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23Q10@183939|Methanococci	183939|Methanococci	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	rpa	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	Rep_fac-A_C,tRNA_anti-codon
MMD2_k127_1583325_2	1459636.NTE_00723	2.361e-26	111.0	COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
MMD2_k127_1583325_7	1123288.SOV_5c00070	1.584e-09	62.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,4H597@909932|Negativicutes	909932|Negativicutes	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
MMD2_k127_1583325_5	304371.MCP_2098	2.777e-13	70.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1583325_11	694429.Pyrfu_1888	4.929e-06	52.0	COG2451@1|root,arCOG04304@2157|Archaea,2XRCP@28889|Crenarchaeota	28889|Crenarchaeota	J	Ribosomal protein L35Ae	rpl35ae	-	-	ko:K02917	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35Ae
MMD2_k127_1583325_3	1121904.ARBP01000005_gene4563	4.62e-23	109.0	COG0638@1|root,COG0638@2|Bacteria	2|Bacteria	O	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMD2_k127_1589804_4	339860.Msp_1301	1.051e-27	115.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD2_k127_1589804_1	386456.JQKN01000001_gene2067	5.818e-114	382.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,23NRF@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMD2_k127_1589804_6	1094980.Mpsy_1395	7.329e-25	116.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,2N9XX@224756|Methanomicrobia	224756|Methanomicrobia	N	Peptidase A24A, prepilin type IV	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
MMD2_k127_1589804_7	1312954.KI914899_gene163	0.0001229	55.0	COG4412@1|root,COG4412@2|Bacteria	2|Bacteria	S	peptidase activity, acting on L-amino acid peptides	-	-	-	ko:K07004,ko:K09955	-	-	-	-	ko00000	-	-	-	Big_4,CW_binding_1,DUF1929,F5_F8_type_C,FIVAR,He_PIG,Laminin_G_3,Peptidase_M6
MMD2_k127_1589804_5	1041930.Mtc_0184	2.469e-27	126.0	COG1520@1|root,arCOG02482@2157|Archaea,2XUI1@28890|Euryarchaeota	28890|Euryarchaeota	T	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
MMD2_k127_1589804_2	1365176.N186_03490	2.094e-89	316.0	COG2064@1|root,arCOG01808@2157|Archaea,2XQ18@28889|Crenarchaeota	28889|Crenarchaeota	N	PFAM type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMD2_k127_1589804_0	694429.Pyrfu_1148	2.503e-163	530.0	COG4962@1|root,arCOG01817@2157|Archaea,2XQ1I@28889|Crenarchaeota	28889|Crenarchaeota	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMD2_k127_1589804_3	717785.HYPMC_3550	3.465e-31	127.0	COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,2TU1P@28211|Alphaproteobacteria,3N93M@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	F420-0:Gamma-glutamyl ligase	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
MMD2_k127_1596533_1	671143.DAMO_0462	4.544e-45	168.0	COG0189@1|root,COG0189@2|Bacteria,2NNM4@2323|unclassified Bacteria	2|Bacteria	HJ	Belongs to the RimK family	-	-	6.3.2.43	ko:K05827,ko:K05844	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	GSH-S_N,RimK
MMD2_k127_1596533_2	1304874.JAFY01000002_gene312	2.903e-39	156.0	COG1526@1|root,COG1526@2|Bacteria,3TBB0@508458|Synergistetes	508458|Synergistetes	C	FdhD/NarQ family	-	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
MMD2_k127_1596533_0	368408.Tpen_0325	5.604e-260	822.0	COG0525@1|root,arCOG00808@2157|Archaea,2XPW9@28889|Crenarchaeota	28889|Crenarchaeota	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMD2_k127_1626867_1	415426.Hbut_0412	7.715e-14	75.0	COG5625@1|root,arCOG04189@2157|Archaea	2157|Archaea	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1626867_0	1123376.AUIU01000013_gene1821	4.598e-168	537.0	COG0499@1|root,COG0499@2|Bacteria,3J0AH@40117|Nitrospirae	40117|Nitrospirae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMD2_k127_1669365_3	573064.Mefer_0243	1.09e-73	259.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,23Q0U@183939|Methanococci	183939|Methanococci	C	TIGRFAM formylmethanofuran dehydrogenase subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
MMD2_k127_1669365_9	323259.Mhun_1984	1.074e-26	114.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
MMD2_k127_1669365_4	386456.JQKN01000002_gene2423	7.875e-54	201.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,23P0Y@183925|Methanobacteria	183925|Methanobacteria	H	ATP dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
MMD2_k127_1669365_16	1094980.Mpsy_2167	1.167e-07	61.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1669365_5	386456.JQKN01000016_gene901	6.646e-53	199.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23NTJ@183925|Methanobacteria	183925|Methanobacteria	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	-
MMD2_k127_1669365_10	579137.Metvu_1562	5.906e-25	117.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23QQY@183939|Methanococci	183939|Methanococci	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD2_k127_1669365_13	644281.MFS40622_0171	4.787e-18	96.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,23QQY@183939|Methanococci	183939|Methanococci	S	PFAM DNA polymerase, beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD2_k127_1669365_14	635013.TherJR_2344	3.753e-17	88.0	COG1763@1|root,COG1763@2|Bacteria,1VFA0@1239|Firmicutes,24IYN@186801|Clostridia,262F6@186807|Peptococcaceae	186801|Clostridia	H	Molybdopterin-guanine dinucleotide biosynthesis	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
MMD2_k127_1669365_12	1049564.TevJSym_ae00680	3.759e-20	95.0	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,1S809@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	DsrE/DsrF-like family	ychN	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
MMD2_k127_1669365_1	1459636.NTE_03020	9.623e-137	446.0	COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota	651137|Thaumarchaeota	D	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,MIT,Vps4_C
MMD2_k127_1669365_11	694429.Pyrfu_1001	3.455e-22	108.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
MMD2_k127_1669365_19	415426.Hbut_0796	6.739e-05	53.0	arCOG04054@1|root,arCOG04054@2157|Archaea,2XPUY@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMD2_k127_1669365_7	1163730.FFONT_0132	1.861e-44	169.0	COG5491@1|root,arCOG00452@2157|Archaea,2XQBW@28889|Crenarchaeota	28889|Crenarchaeota	D	Conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
MMD2_k127_1669365_18	187303.BN69_0699	1.829e-06	59.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,36XQP@31993|Methylocystaceae	28211|Alphaproteobacteria	M	Glutamine amidotransferase domain	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMD2_k127_1669365_0	1455608.JDTH01000002_gene564	3.565e-221	719.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,23S50@183963|Halobacteria	183963|Halobacteria	K	DEAD H associated	lhr1	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMD2_k127_1669365_17	490899.DKAM_0919	2.589e-07	60.0	arCOG05414@1|root,arCOG05414@2157|Archaea,2XS3U@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1669365_8	436308.Nmar_0859	1.874e-30	127.0	COG1896@1|root,arCOG04311@2157|Archaea,41SQE@651137|Thaumarchaeota	651137|Thaumarchaeota	S	HD domain	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
MMD2_k127_1669365_2	1237149.C900_01912	3.244e-76	271.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,47M5W@768503|Cytophagia	976|Bacteroidetes	E	amino acid	yeeF	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
MMD2_k127_1669365_6	523850.TON_0571	5.06e-47	179.0	COG0730@1|root,arCOG02050@2157|Archaea,2XSTS@28890|Euryarchaeota,243BP@183968|Thermococci	183968|Thermococci	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMD2_k127_1699162_0	237368.SCABRO_03442	3.784e-166	537.0	COG0046@1|root,COG0046@2|Bacteria,2IXRT@203682|Planctomycetes	203682|Planctomycetes	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
MMD2_k127_1699162_3	573063.Metin_0735	1.029e-13	73.0	COG1828@1|root,arCOG04462@2157|Archaea,2XYPB@28890|Euryarchaeota	28890|Euryarchaeota	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMD2_k127_1699162_1	391623.TERMP_02035	2.646e-64	233.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,2432Y@183968|Thermococci	183968|Thermococci	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMD2_k127_1699162_2	269797.Mbar_A3630	7.233e-19	96.0	COG0526@1|root,arCOG02498@1|root,arCOG01974@2157|Archaea,arCOG02498@2157|Archaea	2157|Archaea	M	parallel beta-helix repeat	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	NosD,Thioredoxin
MMD2_k127_1757022_4	992406.RIA_0955	4.913e-08	61.0	COG1011@1|root,COG1011@2|Bacteria,4NM66@976|Bacteroidetes,1I188@117743|Flavobacteriia	976|Bacteroidetes	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	yjjG	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMD2_k127_1757022_3	1304880.JAGB01000001_gene136	3.431e-16	85.0	arCOG11023@1|root,2ZBVW@2|Bacteria,1V1HI@1239|Firmicutes,24G3M@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1757022_1	192952.MM_1563	1.443e-68	245.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7NF@28890|Euryarchaeota,2N9QM@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE
MMD2_k127_1757022_2	387631.Asulf_00545	4.223e-58	210.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota,24708@183980|Archaeoglobi	183980|Archaeoglobi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
MMD2_k127_1757022_0	523850.TON_0014	1.616e-73	261.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,24375@183968|Thermococci	183968|Thermococci	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
MMD2_k127_1757022_5	572546.Arcpr_0671	9.57e-05	46.0	COG2005@1|root,arCOG00223@2157|Archaea	2157|Archaea	P	Transcriptional regulator	modA	-	2.10.1.1,3.6.1.55	ko:K02019,ko:K03574,ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	HTH_1,TOBE
MMD2_k127_1792963_17	1235803.C825_04934	3.937e-07	58.0	COG0053@1|root,COG0053@2|Bacteria,4NFBB@976|Bacteroidetes,2G36X@200643|Bacteroidia,2320A@171551|Porphyromonadaceae	976|Bacteroidetes	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMD2_k127_1792963_0	368408.Tpen_0893	1.618e-281	877.0	COG0365@1|root,arCOG04201@2157|Archaea,2XSQM@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM AMP-dependent synthetase and ligase	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMD2_k127_1792963_7	1229520.ADIAL_0722	2.867e-57	206.0	COG1584@1|root,COG1584@2|Bacteria,1TSYX@1239|Firmicutes,4HEDP@91061|Bacilli,27GNS@186828|Carnobacteriaceae	91061|Bacilli	S	GPR1/FUN34/yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMD2_k127_1792963_2	368408.Tpen_0197	1.053e-243	784.0	COG0474@1|root,arCOG01578@2157|Archaea,2XQ51@28889|Crenarchaeota	28889|Crenarchaeota	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD2_k127_1792963_1	1105031.HMPREF1141_1019	1.212e-252	797.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMD2_k127_1792963_4	399549.Msed_0933	1.08e-108	364.0	COG0309@1|root,arCOG00636@2157|Archaea,2XPSN@28889|Crenarchaeota	28889|Crenarchaeota	O	TIGRFAM hydrogenase expression formation protein HypE	-	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
MMD2_k127_1792963_5	1031288.AXAA01000016_gene987	3.478e-108	374.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,36UKJ@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdhA	-	1.17.1.10,1.17.1.11,1.17.1.9	ko:K00123,ko:K05299,ko:K22341	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMD2_k127_1792963_12	1151117.AJLF01000003_gene669	1.581e-41	162.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,242YQ@183968|Thermococci	183968|Thermococci	Q	Pfam:Methyltransf_26	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMD2_k127_1792963_10	634498.mru_0158	2.243e-46	177.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,23NYN@183925|Methanobacteria	183925|Methanobacteria	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMD2_k127_1792963_8	186497.PF1862	9.579e-54	194.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMD2_k127_1792963_16	1131266.ARWQ01000004_gene1488	2.023e-19	93.0	COG1460@1|root,arCOG01016@2157|Archaea,41SQ1@651137|Thaumarchaeota	651137|Thaumarchaeota	K	RNA polymerase Rpb4	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMD2_k127_1792963_15	273063.STK_04590	7.269e-28	115.0	COG2139@1|root,arCOG04129@2157|Archaea,2XQR1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMD2_k127_1792963_6	1094980.Mpsy_2776	9.957e-102	347.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,2N98Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
MMD2_k127_1792963_3	573064.Mefer_0354	6.383e-147	478.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,23QCN@183939|Methanococci	183939|Methanococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMD2_k127_1792963_11	1365176.N186_05390	1.083e-44	171.0	COG1938@1|root,arCOG00347@2157|Archaea,2XQ9W@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMD2_k127_1792963_19	1158318.ATXC01000002_gene1587	2.183e-06	55.0	COG0071@1|root,COG0071@2|Bacteria,2G4AZ@200783|Aquificae	200783|Aquificae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMD2_k127_1792963_13	694429.Pyrfu_0163	2.274e-41	156.0	COG0231@1|root,arCOG04277@2157|Archaea,2XQCW@28889|Crenarchaeota	28889|Crenarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMD2_k127_1792963_9	529709.PYCH_02660	1.961e-46	178.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,243E4@183968|Thermococci	183968|Thermococci	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMD2_k127_1792963_14	868131.MSWAN_1574	2.461e-31	130.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,23P50@183925|Methanobacteria	183925|Methanobacteria	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
MMD2_k127_1792963_18	647113.Metok_0427	1.395e-06	51.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,23QQ3@183939|Methanococci	183939|Methanococci	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
MMD2_k127_1794299_5	694429.Pyrfu_1675	1.371e-58	208.0	COG0097@1|root,arCOG04090@2157|Archaea,2XQ9A@28889|Crenarchaeota	28889|Crenarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMD2_k127_1794299_6	529709.PYCH_01530	4.759e-49	178.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,2440K@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMD2_k127_1794299_14	529709.PYCH_01520	1.931e-17	83.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y6IW@28890|Euryarchaeota,244PP@183968|Thermococci	183968|Thermococci	J	Binds 16S rRNA, required for the assembly of 30S particles	rps14	GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMD2_k127_1794299_4	415426.Hbut_1313	2.49e-60	213.0	COG0094@1|root,arCOG04092@2157|Archaea,2XQDJ@28889|Crenarchaeota	28889|Crenarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMD2_k127_1794299_2	399550.Smar_1031	9.972e-68	238.0	COG1471@1|root,arCOG04093@2157|Archaea,2XPPZ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
MMD2_k127_1794299_10	399550.Smar_1030	3.648e-35	144.0	COG0198@1|root,arCOG04094@2157|Archaea,2XQQB@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L26
MMD2_k127_1794299_7	439481.Aboo_1511	2.418e-48	177.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,3F2NF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMD2_k127_1794299_11	1324957.K933_06443	6.845e-35	138.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,23WBV@183963|Halobacteria	183963|Halobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17p	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMD2_k127_1794299_15	877455.Metbo_0783	7.885e-11	66.0	COG1588@1|root,arCOG00784@2157|Archaea,2Y0EN@28890|Euryarchaeota,23PQP@183925|Methanobacteria	183925|Methanobacteria	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
MMD2_k127_1794299_16	1202768.JROF01000007_gene2697	2.019e-08	59.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,23WY2@183963|Halobacteria	183963|Halobacteria	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMD2_k127_1794299_3	877455.Metbo_0780	1.898e-64	229.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,23NMY@183925|Methanobacteria	183925|Methanobacteria	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMD2_k127_1794299_9	1365176.N186_03390	1.269e-37	148.0	COG0091@1|root,arCOG04098@2157|Archaea,2XQCP@28889|Crenarchaeota	28889|Crenarchaeota	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMD2_k127_1794299_1	386456.JQKN01000001_gene2105	1.784e-110	368.0	COG0409@1|root,arCOG04428@2157|Archaea,2XTJA@28890|Euryarchaeota,23NRS@183925|Methanobacteria	183925|Methanobacteria	O	hydrogenase expression formation protein	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
MMD2_k127_1794299_13	671065.MetMK1DRAFT_00005550	1.232e-19	91.0	COG0298@1|root,arCOG04427@2157|Archaea	2157|Archaea	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
MMD2_k127_1794299_0	342949.PNA2_1469	1.088e-210	678.0	COG0068@1|root,arCOG01187@2157|Archaea,2XTHZ@28890|Euryarchaeota,242XT@183968|Thermococci	183968|Thermococci	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Peptidase_M22,Sua5_yciO_yrdC,zf-HYPF
MMD2_k127_1794299_8	269797.Mbar_A3266	9.74e-41	156.0	COG0778@1|root,arCOG00288@2157|Archaea,2Y6YN@28890|Euryarchaeota,2NB04@224756|Methanomicrobia	224756|Methanomicrobia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMD2_k127_1794299_12	795359.TOPB45_0867	3.579e-24	104.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMD2_k127_183654_2	537013.CLOSTMETH_01282	2.507e-20	94.0	arCOG09714@1|root,316P9@2|Bacteria,1V7WP@1239|Firmicutes,24K29@186801|Clostridia,3WJJJ@541000|Ruminococcaceae	186801|Clostridia	S	COG NOG16854 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_183654_4	555779.Dthio_PD2989	4.109e-06	53.0	COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,42NAN@68525|delta/epsilon subdivisions,2WKXF@28221|Deltaproteobacteria,2MAJC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
MMD2_k127_183654_5	518637.EUBIFOR_02541	2.037e-05	54.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_1,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
MMD2_k127_183654_1	1365176.N186_03495	5.836e-28	123.0	COG1936@1|root,arCOG01038@2157|Archaea,2XQII@28889|Crenarchaeota	28889|Crenarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMD2_k127_183654_0	523850.TON_1692	8.702e-82	282.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,242XU@183968|Thermococci	183968|Thermococci	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
MMD2_k127_183654_3	768710.DesyoDRAFT_1324	1.619e-15	88.0	COG1316@1|root,COG2247@1|root,COG3209@1|root,COG3210@1|root,COG3291@1|root,COG4932@1|root,COG5184@1|root,COG5492@1|root,COG1316@2|Bacteria,COG2247@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1UKQV@1239|Firmicutes	1239|Firmicutes	M	Listeria-Bacteroides repeat domain (List_Bact_rpt)	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new
MMD2_k127_1847993_9	386456.JQKN01000001_gene2131	1.42e-46	173.0	COG1751@1|root,arCOG04343@2157|Archaea,2XW2K@28890|Euryarchaeota,23PIT@183925|Methanobacteria	183925|Methanobacteria	S	Pyruvate kinase, alpha/beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
MMD2_k127_1847993_2	1365176.N186_04140	4.793e-176	561.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMD2_k127_1847993_4	368408.Tpen_0543	1.356e-106	354.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPTF@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD2_k127_1847993_3	391623.TERMP_01558	3.702e-123	406.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,242N1@183968|Thermococci	183968|Thermococci	C	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity	vorA	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
MMD2_k127_1847993_12	985053.VMUT_0399	5.22e-30	121.0	COG1144@1|root,arCOG01605@2157|Archaea,2XQW3@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
MMD2_k127_1847993_7	1041930.Mtc_0840	4.73e-56	201.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,2N9J1@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC-1	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMD2_k127_1847993_10	304371.MCP_0919	1.575e-43	179.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2NAJK@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMD2_k127_1847993_14	1459636.NTE_01468	3.778e-08	56.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
MMD2_k127_1847993_1	1131266.ARWQ01000001_gene1364	3.136e-181	576.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMD2_k127_1847993_11	69014.TK0700	8.366e-31	124.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
MMD2_k127_1847993_0	589924.Ferp_1250	2.016e-317	1007.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
MMD2_k127_1847993_5	1042877.GQS_10240	1.485e-81	278.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,24399@183968|Thermococci	183968|Thermococci	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMD2_k127_1847993_13	572478.Vdis_0767	5.994e-12	69.0	COG4888@1|root,arCOG04136@2157|Archaea,2XRI7@28889|Crenarchaeota	28889|Crenarchaeota	J	Transcription elongation factor Elf1 like	-	-	-	-	-	-	-	-	-	-	-	-	Elf1
MMD2_k127_1847993_6	985053.VMUT_0432	1.721e-66	237.0	COG0171@1|root,arCOG00069@2157|Archaea,2XQ3J@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
MMD2_k127_1847993_8	1234664.AMRO01000002_gene2196	1.883e-52	194.0	COG0388@1|root,COG0388@2|Bacteria,1UX58@1239|Firmicutes,4IE20@91061|Bacilli,1WHNS@129337|Geobacillus	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
MMD2_k127_1885244_9	192952.MM_0114	9.51e-83	291.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMD2_k127_1885244_17	70601.3257966	5.352e-40	151.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,24457@183968|Thermococci	183968|Thermococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMD2_k127_1885244_14	1041930.Mtc_1643	3.079e-51	197.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
MMD2_k127_1885244_28	415426.Hbut_1367	0.0001525	47.0	arCOG07192@1|root,arCOG07192@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1885244_0	930945.SiRe_1832	3.617e-295	922.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPPI@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
MMD2_k127_1885244_26	673860.AciM339_0114	1.082e-10	65.0	COG2092@1|root,arCOG01988@2157|Archaea,2Y75E@28890|Euryarchaeota,3F3FB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
MMD2_k127_1885244_25	572478.Vdis_2202	6.248e-17	82.0	COG2888@1|root,arCOG01989@2157|Archaea,2XRFA@28889|Crenarchaeota	28889|Crenarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMD2_k127_1885244_5	694429.Pyrfu_0109	1.107e-119	394.0	COG0258@1|root,arCOG04050@2157|Archaea,2XPRH@28889|Crenarchaeota	28889|Crenarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMD2_k127_1885244_3	374847.Kcr_1249	1.054e-138	453.0	COG1350@1|root,arCOG01432@2157|Archaea	2157|Archaea	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMD2_k127_1885244_12	415426.Hbut_0632	1.12e-71	248.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMD2_k127_1885244_29	523850.TON_1155	0.0003415	49.0	arCOG00743@1|root,arCOG00743@2157|Archaea,2Y3FU@28890|Euryarchaeota,2445D@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1885244_1	1183377.Py04_0310	8.241e-170	553.0	COG0449@1|root,arCOG00057@2157|Archaea,2XTC0@28890|Euryarchaeota,243IS@183968|Thermococci	183968|Thermococci	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMD2_k127_1885244_11	1459636.NTE_02224	3.317e-74	261.0	COG0640@1|root,arCOG03420@1|root,arCOG01687@2157|Archaea,arCOG03420@2157|Archaea	2157|Archaea	K	PFAM S-layer	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,S_layer_C
MMD2_k127_1885244_20	644281.MFS40622_0014	8.672e-32	129.0	COG2090@1|root,arCOG04171@2157|Archaea,2XXWX@28890|Euryarchaeota,23R2C@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
MMD2_k127_1885244_10	1104324.P186_0723	3.584e-76	268.0	COG0430@1|root,arCOG04125@2157|Archaea,2XPT6@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
MMD2_k127_1885244_22	161156.JQKW01000011_gene958	1.034e-27	114.0	COG1254@1|root,COG1254@2|Bacteria,2GHZK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMD2_k127_1885244_31	1365176.N186_02385	0.0006473	47.0	arCOG05582@1|root,arCOG05582@2157|Archaea,2XSKU@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1885244_8	453591.Igni_0637	1.778e-84	294.0	COG0519@1|root,arCOG00085@2157|Archaea,2XPVC@28889|Crenarchaeota	28889|Crenarchaeota	F	GMP synthase, glutamine-hydrolyzing	guaA	GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
MMD2_k127_1885244_21	1459636.NTE_02510	2.514e-30	127.0	arCOG02103@1|root,arCOG02103@2157|Archaea,41T51@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
MMD2_k127_1885244_13	985053.VMUT_2156	6.678e-54	200.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
MMD2_k127_1885244_27	1459636.NTE_02686	3.932e-10	62.0	arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1885244_7	694429.Pyrfu_1513	1.465e-89	307.0	COG1313@1|root,arCOG00934@2157|Archaea,2XPK3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMD2_k127_1885244_4	415426.Hbut_0492	3.746e-127	415.0	COG1180@1|root,arCOG00946@2157|Archaea,2XPTQ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMD2_k127_1885244_18	391623.TERMP_00651	5.54e-35	137.0	COG1917@1|root,arCOG03004@2157|Archaea,2XYUR@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMD2_k127_1885244_19	386456.JQKN01000012_gene999	8.34e-34	138.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMD2_k127_1885244_30	521011.Mpal_2655	0.0005497	51.0	COG4801@1|root,arCOG02471@2157|Archaea,2XSX3@28890|Euryarchaeota,2N9N8@224756|Methanomicrobia	224756|Methanomicrobia	S	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,Hexapep
MMD2_k127_1885244_16	747365.Thena_0183	1.723e-43	176.0	COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,25BAQ@186801|Clostridia,42JEN@68295|Thermoanaerobacterales	186801|Clostridia	M	Glycosyl transferase family group 2	ydaM	-	2.4.1.336	ko:K19003	ko00561,ko01100,map00561,map01100	-	R02689	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
MMD2_k127_1885244_6	696281.Desru_3661	1.363e-111	382.0	COG4124@1|root,COG4124@2|Bacteria,1U8S3@1239|Firmicutes,24CGR@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 26 family	celH	GO:0003674,GO:0003824,GO:0004553,GO:0008810,GO:0016787,GO:0016798	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Dockerin_1,Glyco_hydro_26
MMD2_k127_1885244_2	565033.GACE_1144	3.692e-155	497.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,246S6@183980|Archaeoglobi	183980|Archaeoglobi	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
MMD2_k127_1885244_24	399550.Smar_0827	1.899e-21	94.0	COG2075@1|root,arCOG01950@2157|Archaea,2XR6Q@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMD2_k127_1885244_23	368408.Tpen_0495	4.509e-24	106.0	COG2053@1|root,arCOG04314@2157|Archaea,2XQTB@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMD2_k127_1885244_15	415426.Hbut_0543	2.741e-44	164.0	COG1358@1|root,arCOG01751@2157|Archaea,2XQH4@28889|Crenarchaeota	28889|Crenarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMD2_k127_189610_4	500635.MITSMUL_03415	2.29e-05	48.0	COG0637@1|root,COG0637@2|Bacteria,1V1NW@1239|Firmicutes,4H4TC@909932|Negativicutes	909932|Negativicutes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMD2_k127_189610_1	935948.KE386494_gene911	3.986e-156	501.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,42ENG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
MMD2_k127_189610_0	1343739.PAP_09580	1.806e-251	805.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,243PB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMD2_k127_189610_2	877455.Metbo_0426	8.327e-87	299.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,23NMB@183925|Methanobacteria	183925|Methanobacteria	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
MMD2_k127_189610_3	633148.Tagg_0667	8.648e-18	84.0	COG1571@1|root,arCOG01115@2157|Archaea,2XPN1@28889|Crenarchaeota	28889|Crenarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743,tRNA_anti-codon
MMD2_k127_1928023_3	374847.Kcr_1054	8.183e-69	242.0	COG0492@1|root,arCOG01296@2157|Archaea	2157|Archaea	C	Thioredoxin reductase	trxB	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
MMD2_k127_1928023_12	1121430.JMLG01000001_gene2170	1.861e-12	79.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2
MMD2_k127_1928023_11	589924.Ferp_0139	4.275e-20	103.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	183980|Archaeoglobi	C	Heterodisulfide reductase subunit A and related polyferredoxins	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,FlpD,Pyr_redox_2
MMD2_k127_1928023_1	643648.Slip_2104	3.357e-91	307.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42KH4@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
MMD2_k127_1928023_0	401526.TcarDRAFT_0268	2.34e-185	590.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,4H2A8@909932|Negativicutes	909932|Negativicutes	C	glutamate synthase (NADPH)	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,NAD_binding_1,Pyr_redox_2
MMD2_k127_1928023_5	387631.Asulf_00555	4.654e-65	228.0	arCOG05906@1|root,arCOG05906@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_1928023_13	1198449.ACAM_0140	2.615e-07	54.0	arCOG04057@1|root,arCOG04057@2157|Archaea,2XSD3@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL38 family	-	-	-	ko:K02923	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L38e
MMD2_k127_1928023_2	1343739.PAP_05760	1.021e-83	287.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2434Q@183968|Thermococci	183968|Thermococci	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMD2_k127_1928023_14	1280663.ATVR01000005_gene1808	2.759e-06	55.0	COG1585@1|root,COG1585@2|Bacteria,1VAS9@1239|Firmicutes,24MRQ@186801|Clostridia,4BZND@830|Butyrivibrio	186801|Clostridia	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
MMD2_k127_1928023_4	69014.TK1316	1.539e-68	244.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,243FX@183968|Thermococci	183968|Thermococci	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMD2_k127_1928023_8	453591.Igni_1153	3.485e-32	129.0	COG0328@1|root,arCOG02942@2157|Archaea,2XR72@28889|Crenarchaeota	28889|Crenarchaeota	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
MMD2_k127_1928023_6	1121423.JONT01000014_gene1280	1.425e-44	174.0	COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,24IQN@186801|Clostridia,266ZM@186807|Peptococcaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
MMD2_k127_1928023_9	930171.Asphe3_30950	3.085e-28	121.0	COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,1W979@1268|Micrococcaceae	201174|Actinobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	arsC	-	1.20.4.1,2.8.4.2	ko:K03741,ko:K18701	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
MMD2_k127_1928023_7	1459636.NTE_00042	1.535e-36	146.0	COG0704@1|root,arCOG00232@2157|Archaea,41T42@651137|Thaumarchaeota	651137|Thaumarchaeota	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
MMD2_k127_1928023_10	472759.Nhal_2292	3.327e-25	105.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1WWM1@135613|Chromatiales	135613|Chromatiales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMD2_k127_226843_1	1459636.NTE_02750	0.0	1340.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMD2_k127_226843_0	1459636.NTE_02749	0.0	1427.0	COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMD2_k127_226843_3	410359.Pcal_2094	3.403e-21	96.0	COG1911@1|root,arCOG01752@2157|Archaea,2XR8J@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
MMD2_k127_226843_2	1459636.NTE_02747	5.575e-43	161.0	COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
MMD2_k127_226843_4	5759.rna_EHI_106280-1	6.836e-19	97.0	COG1196@1|root,KOG0979@2759|Eukaryota,3X8DU@554915|Amoebozoa	554915|Amoebozoa	BDL	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,SMC_N
MMD2_k127_2363091_1	444157.Tneu_1446	5.887e-158	510.0	COG1964@1|root,arCOG00933@2157|Archaea,2XPQM@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMD2_k127_2363091_0	1297581.H919_05834	3.449e-180	581.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HA2G@91061|Bacilli,21V6R@150247|Anoxybacillus	91061|Bacilli	IQ	AMP-binding enzyme C-terminal domain	lcfA	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMD2_k127_2363091_9	525904.Tter_0601	8.925e-24	111.0	COG1073@1|root,COG1073@2|Bacteria,2NRK4@2323|unclassified Bacteria	2|Bacteria	S	Alpha/beta hydrolase of unknown function (DUF1100)	yfhR3	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4,Peptidase_S9
MMD2_k127_2363091_4	374847.Kcr_0965	1.47e-80	282.0	COG1748@1|root,arCOG00243@2157|Archaea	2157|Archaea	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Semialdhyde_dh,UDPG_MGDP_dh_N
MMD2_k127_2363091_6	70601.3257265	2.575e-36	141.0	COG0251@1|root,arCOG01630@2157|Archaea,2XXUZ@28890|Euryarchaeota,244C0@183968|Thermococci	183968|Thermococci	J	Endoribonuclease L-PSP	-	GO:0003674,GO:0003824,GO:0016787,GO:0019239	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
MMD2_k127_2363091_10	646529.Desaci_1639	8.143e-21	96.0	arCOG09714@1|root,33H0I@2|Bacteria,1UDFF@1239|Firmicutes,24N03@186801|Clostridia,26691@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TIGR04076 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2363091_8	273063.STK_00800	1.712e-35	140.0	COG1545@1|root,arCOG01283@2157|Archaea,2XQEP@28889|Crenarchaeota	28889|Crenarchaeota	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMD2_k127_2363091_2	698757.Pogu_1346	9.775e-152	488.0	COG0183@1|root,arCOG01278@2157|Archaea,2XPZV@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM Thiolase	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMD2_k127_2363091_5	572478.Vdis_0258	9.526e-78	268.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMD2_k127_2363091_3	1121405.dsmv_0664	9.366e-115	381.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJUN@28221|Deltaproteobacteria,2MIK6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD2_k127_2363091_7	589924.Ferp_1942	4.37e-36	142.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,245SW@183980|Archaeoglobi	183980|Archaeoglobi	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMD2_k127_23905_3	768706.Desor_1648	1.429e-38	157.0	COG5598@1|root,COG5598@2|Bacteria,1V08E@1239|Firmicutes,24BDE@186801|Clostridia,263XC@186807|Peptococcaceae	186801|Clostridia	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
MMD2_k127_23905_1	877455.Metbo_1025	1.426e-78	274.0	COG0407@1|root,arCOG03324@2157|Archaea,2XVT1@28890|Euryarchaeota,23PXK@183925|Methanobacteria	183925|Methanobacteria	H	Methyltransferase MtaA	-	-	2.1.1.246	ko:K14080	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R09098,R10000	RC00035,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
MMD2_k127_23905_0	1304874.JAFY01000002_gene577	5.265e-86	303.0	COG5598@1|root,COG5598@2|Bacteria,3TC8U@508458|Synergistetes	508458|Synergistetes	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
MMD2_k127_23905_2	1089553.Tph_c27670	1.393e-52	193.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548,ko:K14084	ko00270,ko00450,ko00670,ko00680,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00680,map01100,map01110,map01120,map01200,map01230	M00017,M00563	R00946,R09124,R09365	RC00035,RC00113,RC00732,RC01241,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
MMD2_k127_2395307_2	1459636.NTE_01818	1.949e-24	108.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
MMD2_k127_2395307_3	666686.B1NLA3E_05925	2.779e-24	107.0	COG0517@1|root,COG0517@2|Bacteria,1V9ZB@1239|Firmicutes,4ISB2@91061|Bacilli,1ZS4F@1386|Bacillus	91061|Bacilli	S	COG0517 FOG CBS domain	yhcV	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD2_k127_2395307_4	351160.RCIX890	4.899e-20	102.0	COG0392@1|root,arCOG00899@2157|Archaea	2157|Archaea	Q	integral membrane protein	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
MMD2_k127_2395307_1	1229909.NSED_01595	1.951e-80	284.0	COG0053@1|root,arCOG01474@2157|Archaea,41SXN@651137|Thaumarchaeota	651137|Thaumarchaeota	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMD2_k127_2395307_0	368408.Tpen_0848	3.342e-134	441.0	COG0017@1|root,arCOG00407@2157|Archaea,2XQ0M@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMD2_k127_2418215_4	1365176.N186_06060	3.803e-55	199.0	COG1940@1|root,arCOG04280@2157|Archaea,2XPSQ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMD2_k127_2418215_3	936596.HMPREF1495_1368	2.819e-56	205.0	COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,1HUHI@1164882|Lachnoanaerobaculum	186801|Clostridia	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
MMD2_k127_2418215_1	1229909.NSED_07595	5.278e-97	323.0	COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMD2_k127_2418215_2	1304284.L21TH_1260	3.902e-58	208.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,36HZI@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
MMD2_k127_2418215_6	342949.PNA2_1731	0.000737	48.0	arCOG03769@1|root,arCOG03769@2157|Archaea,2Y4FT@28890|Euryarchaeota,244NG@183968|Thermococci	183968|Thermococci	M	glucosylceramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2418215_5	468059.AUHA01000006_gene2847	2.039e-17	89.0	COG0590@1|root,COG0590@2|Bacteria,4NNMU@976|Bacteroidetes,1IT52@117747|Sphingobacteriia	976|Bacteroidetes	FJ	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	guaD	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	MafB19-deam,dCMP_cyt_deam_1
MMD2_k127_2418215_0	572478.Vdis_1983	2.586e-107	356.0	COG1964@1|root,arCOG00933@2157|Archaea,2XPQM@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMD2_k127_2449680_0	671143.DAMO_0464	6.226e-151	493.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
MMD2_k127_2449680_1	644281.MFS40622_0820	2.972e-137	447.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD2_k127_2450414_16	643648.Slip_2104	1.715e-91	308.0	COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,42KH4@68298|Syntrophomonadaceae	186801|Clostridia	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.18.1.2,1.19.1.1	ko:K00528,ko:K16951	ko00920,ko01120,map00920,map01120	-	R00858,R10146,R10159	RC00065	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
MMD2_k127_2450414_4	340099.Teth39_0216	2.574e-194	617.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	gltA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMD2_k127_2450414_21	1265505.ATUG01000002_gene2280	3.374e-70	251.0	COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,1MWJC@1224|Proteobacteria,42QB3@68525|delta/epsilon subdivisions,2WM0Q@28221|Deltaproteobacteria,2MIXS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit	-	-	1.12.98.1	ko:K00441	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,FrhB_FdhB_C,FrhB_FdhB_N
MMD2_k127_2450414_29	224325.AF_1743	3.47e-41	158.0	COG1522@1|root,arCOG01585@2157|Archaea,2Y7PY@28890|Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD2_k127_2450414_44	69014.TK2052	2.22e-12	70.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y1MB@28890|Euryarchaeota,244GZ@183968|Thermococci	183968|Thermococci	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD2_k127_2450414_43	1040987.AZUY01000045_gene5268	2.612e-13	71.0	COG3205@1|root,COG3205@2|Bacteria,1NFFT@1224|Proteobacteria,2UJ3P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2061)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2061
MMD2_k127_2450414_10	399550.Smar_1225	3.958e-116	382.0	COG0470@1|root,arCOG00469@2157|Archaea,2XPQ0@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,Rep_fac_C,RuvB_N
MMD2_k127_2450414_14	415426.Hbut_0906	7.614e-93	319.0	COG0470@1|root,arCOG00470@2157|Archaea,2XPN9@28889|Crenarchaeota	28889|Crenarchaeota	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,RFC1,Rad17
MMD2_k127_2450414_35	515635.Dtur_0256	6.551e-28	117.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria	2|Bacteria	J	methionyl-tRNA aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20	ko:K01874,ko:K01890,ko:K06878	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMD2_k127_2450414_28	243232.MJ_0837	2.608e-45	174.0	COG3481@1|root,arCOG01861@2157|Archaea,2XW7M@28890|Euryarchaeota,23Q6Q@183939|Methanococci	183939|Methanococci	H	PFAM metal-dependent phosphohydrolase, HD sub domain	-	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.1.4.56	ko:K17487	ko00790,map00790	-	R10344,R10345	RC00763,RC03130	ko00000,ko00001,ko01000	-	-	-	HD
MMD2_k127_2450414_26	368408.Tpen_0682	1.3e-47	179.0	COG1515@1|root,arCOG00929@2157|Archaea,2XQNE@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
MMD2_k127_2450414_33	391623.TERMP_00569	2.585e-31	131.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,242PY@183968|Thermococci	183968|Thermococci	J	Translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
MMD2_k127_2450414_41	637389.Acaty_c1628	6.797e-17	93.0	COG0477@1|root,COG2814@2|Bacteria,1PGGB@1224|Proteobacteria,1RU5P@1236|Gammaproteobacteria,2NDEV@225057|Acidithiobacillales	225057|Acidithiobacillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD2_k127_2450414_17	696281.Desru_0068	7.978e-77	269.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260GV@186807|Peptococcaceae	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
MMD2_k127_2450414_13	453591.Igni_1433	1.495e-100	336.0	COG0731@1|root,arCOG04174@2157|Archaea,2XPM3@28889|Crenarchaeota	28889|Crenarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMD2_k127_2450414_39	906968.Trebr_2211	1.118e-22	103.0	COG1433@1|root,COG1433@2|Bacteria,2J9C3@203691|Spirochaetes	203691|Spirochaetes	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
MMD2_k127_2450414_12	644281.MFS40622_0057	1.026e-100	341.0	COG0112@1|root,arCOG00070@2157|Archaea,2XU0H@28890|Euryarchaeota,23RGY@183939|Methanococci	183939|Methanococci	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one- carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMD2_k127_2450414_51	2325.TKV_c14280	8.733e-07	61.0	COG2270@1|root,COG2270@2|Bacteria,1UHZ6@1239|Firmicutes,25E7U@186801|Clostridia,42FVR@68295|Thermoanaerobacterales	186801|Clostridia	S	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMD2_k127_2450414_49	1163730.FFONT_0776	1.239e-07	57.0	arCOG05464@1|root,arCOG05464@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2450414_50	1459636.NTE_02864	7.448e-07	53.0	COG1996@1|root,arCOG04341@2157|Archaea,41SWH@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	-
MMD2_k127_2450414_23	415426.Hbut_0088	4.552e-66	236.0	COG2520@1|root,arCOG00033@2157|Archaea,2XPMY@28889|Crenarchaeota	28889|Crenarchaeota	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMD2_k127_2450414_37	1459636.NTE_02308	6.435e-25	106.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
MMD2_k127_2450414_18	420247.Msm_0882	9.892e-76	265.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,23NSJ@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Oxidoreductase	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMD2_k127_2450414_32	673860.AciM339_0814	1.666e-36	154.0	COG0677@1|root,arCOG00252@2157|Archaea,2Y65J@28890|Euryarchaeota,3F3B1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	TIGRFAM nucleotide sugar dehydrogenase	-	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
MMD2_k127_2450414_7	1041930.Mtc_1252	1.667e-125	416.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMD2_k127_2450414_22	572478.Vdis_1821	2.145e-68	245.0	COG1208@1|root,arCOG00666@2157|Archaea,2XPX1@28889|Crenarchaeota	28889|Crenarchaeota	M	transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD2_k127_2450414_38	1459636.NTE_03306	1.523e-24	112.0	COG1958@1|root,arCOG00999@2157|Archaea	2157|Archaea	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM,Lsm_C,SM-ATX
MMD2_k127_2450414_31	604354.TSIB_0577	3.297e-40	158.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,242P6@183968|Thermococci	183968|Thermococci	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMD2_k127_2450414_15	1157490.EL26_11975	7.886e-93	331.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
MMD2_k127_2450414_8	694429.Pyrfu_0098	1.449e-121	408.0	COG0343@1|root,arCOG00989@2157|Archaea,2XPSY@28889|Crenarchaeota	28889|Crenarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
MMD2_k127_2450414_36	1041930.Mtc_0117	2.619e-27	119.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,2N9Q2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
MMD2_k127_2450414_11	1459636.NTE_03316	1.115e-110	371.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
MMD2_k127_2450414_48	529709.PYCH_00970	6.065e-08	59.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,243DU@183968|Thermococci	183968|Thermococci	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
MMD2_k127_2450414_46	593117.TGAM_0860	8.027e-11	65.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota,243DU@183968|Thermococci	183968|Thermococci	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
MMD2_k127_2450414_42	397948.Cmaq_1594	3.529e-14	82.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSEQ@28889|Crenarchaeota	28889|Crenarchaeota	S	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2450414_2	671143.DAMO_0464	3.974e-304	959.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,2NNW5@2323|unclassified Bacteria	2|Bacteria	C	synthetase (ADP forming), alpha	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
MMD2_k127_2450414_6	573063.Metin_0381	5.657e-152	492.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QK4@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD2_k127_2450414_5	335543.Sfum_1179	9.568e-164	532.0	COG1148@1|root,COG1148@2|Bacteria,1PZ04@1224|Proteobacteria,42PT3@68525|delta/epsilon subdivisions,2WMJU@28221|Deltaproteobacteria,2MR5J@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
MMD2_k127_2450414_25	429009.Adeg_1784	1.054e-60	218.0	COG1894@1|root,COG1908@1|root,COG1894@2|Bacteria,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
MMD2_k127_2450414_0	429009.Adeg_1885	0.0	1127.0	COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,42FJG@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Pyr_redox_2
MMD2_k127_2450414_24	429009.Adeg_2015	1.192e-64	224.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD,NADH_4Fe-4S
MMD2_k127_2450414_34	1236689.MMALV_13670	2.927e-28	120.0	COG2048@1|root,arCOG00964@2157|Archaea,2XZ7E@28890|Euryarchaeota,3F2WA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD2_k127_2450414_19	439235.Dalk_5067	1.906e-72	254.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MJQR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	heterodisulfide reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD2_k127_2450414_9	429009.Adeg_2014	6.002e-117	385.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia,42HGR@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
MMD2_k127_2450414_3	1379698.RBG1_1C00001G0047	3.146e-205	649.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
MMD2_k127_2450414_40	186497.PF0617	5.315e-20	96.0	COG0680@1|root,arCOG04429@2157|Archaea,2XXAF@28890|Euryarchaeota,245I8@183968|Thermococci	183968|Thermococci	O	Hydrogenase maturation protease	-	-	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
MMD2_k127_2450414_47	272558.10174070	1.486e-10	69.0	COG0454@1|root,COG2818@1|root,COG0456@2|Bacteria,COG2818@2|Bacteria,1V6D6@1239|Firmicutes,4HIQX@91061|Bacilli,1ZGF7@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yxbD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Acetyltransf_1
MMD2_k127_2450414_52	368408.Tpen_0140	3.049e-05	54.0	COG0717@1|root,arCOG04048@2157|Archaea,2XQDF@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
MMD2_k127_2450414_27	573063.Metin_1389	1.21e-45	171.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMD2_k127_2450414_1	368408.Tpen_0588	3.095e-310	970.0	COG0574@1|root,arCOG01111@2157|Archaea,2XPWQ@28889|Crenarchaeota	28889|Crenarchaeota	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMD2_k127_2450414_20	877455.Metbo_0198	8.259e-72	254.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23NUP@183925|Methanobacteria	183925|Methanobacteria	J	Diphthamide	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMD2_k127_2450414_30	573063.Metin_0255	6.523e-41	160.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,23QVD@183939|Methanococci	183939|Methanococci	Q	Methyltransferase	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
MMD2_k127_2450414_45	386456.JQKN01000012_gene987	2.695e-12	71.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,23P5F@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N
MMD2_k127_2452169_1	573413.Spirs_3743	8.94e-62	222.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMD2_k127_2452169_3	309799.DICTH_1951	4.022e-21	103.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
MMD2_k127_2452169_6	246969.TAM4_549	8.037e-10	64.0	COG1694@1|root,arCOG01084@2157|Archaea,2Y4H2@28890|Euryarchaeota,244H3@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
MMD2_k127_2452169_5	387631.Asulf_00452	2.087e-17	85.0	COG0826@1|root,arCOG03202@2157|Archaea	2157|Archaea	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
MMD2_k127_2452169_2	485916.Dtox_0803	1.204e-37	146.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24N7A@186801|Clostridia,262C9@186807|Peptococcaceae	186801|Clostridia	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
MMD2_k127_2452169_0	694429.Pyrfu_0643	2.064e-207	661.0	COG0504@1|root,arCOG00063@2157|Archaea,2XPKS@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMD2_k127_2452169_4	1220534.B655_0937	2.009e-18	88.0	arCOG01917@1|root,arCOG01917@2157|Archaea	2157|Archaea	M	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	zf-ribbon_3,zinc_ribbon_2
MMD2_k127_2485270_3	1125863.JAFN01000001_gene1627	1.652e-26	118.0	COG1145@1|root,COG1943@1|root,COG1145@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
MMD2_k127_2485270_4	1455608.JDTH01000001_gene3235	6.957e-16	84.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,23SJ4@183963|Halobacteria	183963|Halobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMD2_k127_2485270_2	273068.TTE0091	1.129e-64	228.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,42FGP@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
MMD2_k127_2485270_0	292459.STH1647	7.806e-117	387.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMD2_k127_2485270_7	1379698.RBG1_1C00001G1554	2.203e-08	57.0	COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria	2|Bacteria	P	E1-E2 ATPase	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
MMD2_k127_2485270_5	1459636.NTE_02126	1.441e-15	84.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
MMD2_k127_2485270_6	933801.Ahos_0782	2.501e-10	68.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD2_k127_2485270_1	1449126.JQKL01000008_gene296	2.923e-87	293.0	COG1773@1|root,COG1853@1|root,COG1773@2|Bacteria,COG1853@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia	186801|Clostridia	C	rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Rubredoxin
MMD2_k127_2485270_9	398512.JQKC01000017_gene3048	0.0001757	54.0	COG3507@1|root,COG3507@2|Bacteria,1TR04@1239|Firmicutes,24ATC@186801|Clostridia,3WG7I@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.55	ko:K15921	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	CBM6,GH43	-	AbfB,Big_3,CBM_2,CBM_4_9,CBM_6,Dockerin_1,Esterase,Glyco_hydro_43,RicinB_lectin_2
MMD2_k127_2485270_8	374847.Kcr_0680	0.0001025	53.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,NosD
MMD2_k127_2534379_2	671065.MetMK1DRAFT_00008670	8.225e-05	54.0	COG1522@1|root,arCOG01586@2157|Archaea	2157|Archaea	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2534379_1	1163730.FFONT_1084	1.038e-14	78.0	COG1308@1|root,arCOG04061@2157|Archaea,2XR2D@28889|Crenarchaeota	28889|Crenarchaeota	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
MMD2_k127_2534379_0	1459636.NTE_02878	6.058e-159	516.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMD2_k127_2592540_2	1536774.H70357_04610	1.469e-59	220.0	COG2159@1|root,COG2159@2|Bacteria,1V9T6@1239|Firmicutes,4HKS1@91061|Bacilli,272KI@186822|Paenibacillaceae	91061|Bacilli	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
MMD2_k127_2592540_0	138119.DSY3648	8.697e-72	260.0	COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,24Y6B@186801|Clostridia,263S7@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
MMD2_k127_2592540_5	1189612.A33Q_3461	4.963e-33	142.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,4NFEW@976|Bacteroidetes,47NZC@768503|Cytophagia	976|Bacteroidetes	E	Zinc-binding dehydrogenase	-	-	-	ko:K02030,ko:K03810	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	ADH_zinc_N,GFO_IDH_MocA
MMD2_k127_2592540_6	573.JG24_17555	0.0003293	49.0	299ND@1|root,2ZWQQ@2|Bacteria,1NQCC@1224|Proteobacteria,1SPBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
MMD2_k127_2592540_1	756499.Desde_0778	1.155e-63	233.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24HJC@186801|Clostridia,264WD@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_10,Fer4_8
MMD2_k127_2592540_4	1089553.Tph_c10350	1.015e-37	159.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,42EX2@68295|Thermoanaerobacterales	186801|Clostridia	C	FAD linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMD2_k127_2592540_3	697303.Thewi_2114	2.78e-40	156.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
MMD2_k127_2604171_1	204669.Acid345_2245	3.13e-14	77.0	COG0053@1|root,COG0053@2|Bacteria,3Y43E@57723|Acidobacteria,2JIIM@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMD2_k127_2604171_0	456442.Mboo_1285	2.296e-213	691.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD2_k127_2636819_9	263820.PTO0734	3.283e-15	78.0	COG0492@1|root,arCOG01296@2157|Archaea,2XTJW@28890|Euryarchaeota,2424P@183967|Thermoplasmata	183967|Thermoplasmata	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMD2_k127_2636819_3	1047013.AQSP01000109_gene2441	1.375e-89	303.0	COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
MMD2_k127_2636819_8	335543.Sfum_0267	9.006e-19	88.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
MMD2_k127_2636819_2	1125863.JAFN01000001_gene2931	1.783e-106	356.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_10,Fer4_8,Fer4_9,Nitrate_red_gam
MMD2_k127_2636819_0	693661.Arcve_1116	1.776e-201	654.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02475@2157|Archaea,2XT3X@28890|Euryarchaeota,245U1@183980|Archaeoglobi	28890|Euryarchaeota	C	Heterodisulfide reductase subunit A and related polyferredoxins	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_4,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
MMD2_k127_2636819_7	436308.Nmar_0705	2.322e-23	111.0	COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMD2_k127_2636819_10	351160.RCIX391	0.0003696	50.0	COG1413@1|root,arCOG06493@2157|Archaea	2157|Archaea	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
MMD2_k127_2636819_6	1265505.ATUG01000001_gene3637	8.8e-67	236.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42PYM@68525|delta/epsilon subdivisions,2WJ37@28221|Deltaproteobacteria,2MIP8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMD2_k127_2636819_4	387631.Asulf_01435	3.756e-84	289.0	COG2025@1|root,arCOG00447@2157|Archaea,2XT06@28890|Euryarchaeota,245ZU@183980|Archaeoglobi	183980|Archaeoglobi	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMD2_k127_2636819_1	589924.Ferp_1579	2.652e-121	400.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,245TD@183980|Archaeoglobi	183980|Archaeoglobi	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD2_k127_2636819_5	698757.Pogu_2676	5.764e-73	254.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMD2_k127_2654729_2	604354.TSIB_1794	1.393e-09	69.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,2432C@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMD2_k127_2654729_0	1163730.FFONT_0955	2.32e-51	205.0	COG1269@1|root,arCOG04138@2157|Archaea,2XQ7V@28889|Crenarchaeota	28889|Crenarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMD2_k127_2654729_1	1123274.KB899427_gene3356	1.919e-12	70.0	COG1436@1|root,COG1436@2|Bacteria,2J8AJ@203691|Spirochaetes	203691|Spirochaetes	C	-ATPase subunit F	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMD2_k127_2654729_4	580332.Slit_2553	0.0003498	50.0	COG1390@1|root,COG1390@2|Bacteria,1R8BT@1224|Proteobacteria,2W49R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	V-type proton ATPase subunit E	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
MMD2_k127_2654729_3	694429.Pyrfu_0866	1.771e-05	48.0	COG1155@1|root,arCOG00868@2157|Archaea,2XPZE@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMD2_k127_2777589_9	1125699.HMPREF9194_01682	0.000108	48.0	COG3875@1|root,COG3875@2|Bacteria,2J6AY@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
MMD2_k127_2777589_4	996637.SGM_1091	9.547e-57	210.0	COG1619@1|root,COG1619@2|Bacteria,2GNW5@201174|Actinobacteria	201174|Actinobacteria	V	proteins homologs of microcin C7 resistance protein MccF	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
MMD2_k127_2777589_5	1459636.NTE_00612	5.925e-43	162.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMD2_k127_2777589_3	374847.Kcr_0094	1.066e-64	227.0	COG1838@1|root,arCOG04406@2157|Archaea	2157|Archaea	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2,4.2.1.32	ko:K01676,ko:K01678,ko:K03780	ko00020,ko00620,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00630,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00339,R01082	RC00443,RC01382	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
MMD2_k127_2777589_2	1343739.PAP_05865	1.083e-93	316.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,242SI@183968|Thermococci	183968|Thermococci	C	Fumarate hydratase	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
MMD2_k127_2777589_1	1343739.PAP_10275	6.786e-109	362.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
MMD2_k127_2777589_8	195522.BD01_1581	5.952e-06	54.0	arCOG05775@1|root,arCOG05775@2157|Archaea,2XXSH@28890|Euryarchaeota,244BF@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2777589_6	4513.MLOC_36909.1	5.698e-21	102.0	COG1814@1|root,KOG4473@2759|Eukaryota,37J7N@33090|Viridiplantae,3GP6E@35493|Streptophyta,3MAK6@4447|Liliopsida,3IU3E@38820|Poales	35493|Streptophyta	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
MMD2_k127_2777589_0	604354.TSIB_1121	2.793e-121	415.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMD2_k127_2777589_7	929794.CALV01000065_gene1616	6.61e-10	61.0	2E4EA@1|root,32Z9I@2|Bacteria,1PWSF@1224|Proteobacteria,2V587@28211|Alphaproteobacteria,48UAE@772|Bartonellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_2847475_6	1006006.Mcup_0249	1.215e-43	162.0	COG0315@1|root,arCOG01530@2157|Archaea,2XQM5@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
MMD2_k127_2847475_7	999630.TUZN_1638	1.068e-09	64.0	COG0640@1|root,arCOG04056@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5,TrmB
MMD2_k127_2847475_4	985053.VMUT_0890	1.385e-67	245.0	COG1474@1|root,arCOG00467@2157|Archaea,2XPZB@28889|Crenarchaeota	28889|Crenarchaeota	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
MMD2_k127_2847475_3	945713.IALB_1115	2.173e-75	258.0	COG1945@1|root,COG1945@2|Bacteria	2|Bacteria	I	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
MMD2_k127_2847475_1	529709.PYCH_13930	6.186e-85	286.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,24332@183968|Thermococci	183968|Thermococci	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMD2_k127_2847475_5	693661.Arcve_0366	2.771e-50	190.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,246S5@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
MMD2_k127_2847475_0	1094980.Mpsy_0788	3.678e-164	539.0	COG3408@1|root,arCOG03287@2157|Archaea,2XUJF@28890|Euryarchaeota,2N90H@224756|Methanomicrobia	224756|Methanomicrobia	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
MMD2_k127_2847475_2	521045.Kole_1921	8.924e-78	272.0	COG1085@1|root,COG1085@2|Bacteria,2GCAX@200918|Thermotogae	200918|Thermotogae	C	galactose-1-phosphate uridylyltransferase	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0896	GalP_UDP_tr_C,GalP_UDP_transf
MMD2_k127_3033020_1	694429.Pyrfu_1705	4.225e-75	260.0	COG0423@1|root,arCOG00405@2157|Archaea,2XPSF@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMD2_k127_3033020_4	436308.Nmar_1038	5.344e-26	116.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
MMD2_k127_3033020_2	1459636.NTE_01764	1.687e-56	202.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
MMD2_k127_3033020_6	1461577.CCMH01000008_gene2283	1.187e-05	54.0	COG0526@1|root,COG0526@2|Bacteria,4NQI3@976|Bacteroidetes,1I2TH@117743|Flavobacteriia	976|Bacteroidetes	CO	Thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin,Thioredoxin_9
MMD2_k127_3033020_0	330779.Saci_1199	1.458e-140	458.0	COG1208@1|root,arCOG00666@2157|Archaea,2XQ37@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,NTP_transferase
MMD2_k127_3033020_3	1163730.FFONT_1134	3.499e-50	189.0	COG0382@1|root,arCOG00476@2157|Archaea,2XQNM@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMD2_k127_3033020_5	573413.Spirs_3744	7.115e-21	103.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMD2_k127_3174836_1	696369.KI912183_gene2506	1.066e-121	406.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260VN@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMD2_k127_3174836_11	1094980.Mpsy_2536	2.827e-14	73.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
MMD2_k127_3174836_7	416591.Tlet_1813	1.256e-37	146.0	COG0454@1|root,COG0456@2|Bacteria,2GDPE@200918|Thermotogae	200918|Thermotogae	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD2_k127_3174836_5	1396418.BATQ01000060_gene2059	1.473e-41	158.0	COG0454@1|root,COG0456@2|Bacteria,46SWZ@74201|Verrucomicrobia,2IVZ7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD2_k127_3174836_12	1047013.AQSP01000105_gene1458	8.622e-13	74.0	2ERMK@1|root,33J72@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
MMD2_k127_3174836_6	592015.HMPREF1705_00457	2.197e-40	158.0	COG0765@1|root,COG0765@2|Bacteria,3TAAM@508458|Synergistetes	508458|Synergistetes	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
MMD2_k127_3174836_2	1227453.C444_05251	5.374e-73	254.0	COG1126@1|root,arCOG00923@2157|Archaea,2XVB5@28890|Euryarchaeota,23SDF@183963|Halobacteria	183963|Halobacteria	E	COG1126 ABC-type polar amino acid transport system, ATPase component	glnQ	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
MMD2_k127_3174836_8	521011.Mpal_1659	4.904e-36	145.0	COG0765@1|root,arCOG01798@2157|Archaea,2XVBC@28890|Euryarchaeota,2NBJ2@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
MMD2_k127_3174836_9	521000.PROVRETT_06384	3.39e-24	113.0	COG0834@1|root,COG0834@2|Bacteria,1MXIA@1224|Proteobacteria,1RPXK@1236|Gammaproteobacteria,3Z7WX@586|Providencia	1236|Gammaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	artI	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0034618,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043090,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0097638,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902023,GO:1902475,GO:1903400,GO:1903825,GO:1903826,GO:1905039,GO:1990822	-	ko:K09996,ko:K09997,ko:K10014	ko02010,map02010	M00226,M00229	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.1,3.A.1.3.3	-	iG2583_1286.G2583_1094,iLF82_1304.LF82_0153,iNRG857_1313.NRG857_03895,iPC815.YPO1351,iUMN146_1321.UM146_13350,iZ_1308.Z1090	SBP_bac_3
MMD2_k127_3174836_0	192952.MM_3279	7.25e-185	591.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMD2_k127_3174836_4	351160.RCIX701	1.917e-49	183.0	COG4430@1|root,arCOG10241@2157|Archaea,2XUJA@28890|Euryarchaeota	28890|Euryarchaeota	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
MMD2_k127_3174836_3	273116.14324844	6.515e-50	186.0	COG0500@1|root,arCOG04734@2157|Archaea,2XWDH@28890|Euryarchaeota	28890|Euryarchaeota	Q	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMD2_k127_3231673_11	1220534.B655_1048	2.052e-09	69.0	arCOG02499@1|root,arCOG02501@1|root,arCOG02499@2157|Archaea,arCOG02501@2157|Archaea,2Y0FJ@28890|Euryarchaeota	28890|Euryarchaeota	O	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD
MMD2_k127_3231673_10	391623.TERMP_00664	6.909e-14	81.0	COG1475@1|root,arCOG00622@2157|Archaea,2XTYJ@28890|Euryarchaeota,244C2@183968|Thermococci	183968|Thermococci	K	ParB-like nuclease domain	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
MMD2_k127_3231673_9	304371.MCP_1403	4.189e-17	87.0	COG1970@1|root,arCOG05213@2157|Archaea,2XZ6U@28890|Euryarchaeota,2N9XV@224756|Methanomicrobia	224756|Methanomicrobia	M	Large-conductance mechanosensitive channel, MscL	-	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
MMD2_k127_3231673_5	309801.trd_A0619	3.65e-35	136.0	COG4274@1|root,COG4274@2|Bacteria,2GBAJ@200795|Chloroflexi,27YIF@189775|Thermomicrobia	189775|Thermomicrobia	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
MMD2_k127_3231673_7	323259.Mhun_3201	6.076e-31	127.0	COG0745@1|root,arCOG02595@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
MMD2_k127_3231673_6	469381.Dpep_1782	6.676e-33	143.0	COG4552@1|root,COG4552@2|Bacteria,3TBYF@508458|Synergistetes	508458|Synergistetes	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
MMD2_k127_3231673_2	1123392.AQWL01000004_gene2612	1.774e-68	249.0	COG0477@1|root,COG2814@2|Bacteria,1RB5E@1224|Proteobacteria,2VQNK@28216|Betaproteobacteria,1KSII@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Uncharacterised MFS-type transporter YbfB	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMD2_k127_3231673_12	65093.PCC7418_2948	9.846e-07	57.0	COG0454@1|root,COG0456@2|Bacteria,1G5GJ@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD2_k127_3231673_4	309803.CTN_0895	7.499e-37	147.0	COG1327@1|root,COG1327@2|Bacteria,2GCWA@200918|Thermotogae	200918|Thermotogae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
MMD2_k127_3231673_0	632518.Calow_0403	2.323e-317	984.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,42ET1@68295|Thermoanaerobacterales	186801|Clostridia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,Glutaredoxin,NRDD
MMD2_k127_3231673_3	1232410.KI421428_gene1013	4.615e-57	207.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria,43SFR@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	4Fe-4S single cluster domain	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMD2_k127_3231673_1	374847.Kcr_0638	2.779e-78	281.0	arCOG02559@1|root,arCOG02559@2157|Archaea	2157|Archaea	P	by modhmm	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
MMD2_k127_3231673_8	591019.Shell_1666	4.62e-19	94.0	COG2012@1|root,arCOG04258@2157|Archaea,2XR25@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMD2_k127_3232028_12	565033.GACE_2005	1.873e-26	110.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,246K3@183980|Archaeoglobi	183980|Archaeoglobi	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMD2_k127_3232028_5	386456.JQKN01000003_gene421	1.211e-93	318.0	COG0524@1|root,arCOG00014@2157|Archaea,2XU7Z@28890|Euryarchaeota,23NZS@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMD2_k127_3232028_1	868131.MSWAN_0958	1.883e-123	402.0	COG2037@1|root,arCOG02695@2157|Archaea,2XUV2@28890|Euryarchaeota,23NJN@183925|Methanobacteria	183925|Methanobacteria	C	Formylmethanofuran-tetrahydromethanopterin formyltransferase	ftr1	-	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
MMD2_k127_3232028_8	224719.Abm4_0937	4.231e-65	236.0	COG4030@1|root,arCOG01161@2157|Archaea,2XWWH@28890|Euryarchaeota,23NXN@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF2961)	ehaR	-	-	ko:K14109	-	-	-	-	ko00000	-	-	-	-
MMD2_k127_3232028_7	304371.MCP_2597	1.482e-68	251.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,2N976@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM Phosphoribosylglycinamide synthetase	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3513	GARS_A,GARS_C,GARS_N
MMD2_k127_3232028_6	523845.AQXV01000047_gene780	1.08e-85	302.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,23Q7H@183939|Methanococci	183939|Methanococci	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
MMD2_k127_3232028_0	224325.AF_0920	8.075e-136	445.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2460D@183980|Archaeoglobi	183980|Archaeoglobi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMD2_k127_3232028_13	386456.JQKN01000019_gene1279	3.964e-22	103.0	COG0195@1|root,arCOG01761@2157|Archaea,2XWJU@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	KH_5
MMD2_k127_3232028_11	523850.TON_0930	1.1e-27	115.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMD2_k127_3232028_10	523850.TON_1976	1.306e-41	157.0	COG1522@1|root,arCOG01118@2157|Archaea,2XWRI@28890|Euryarchaeota,24403@183968|Thermococci	183968|Thermococci	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_Crp_2,MarR_2
MMD2_k127_3232028_3	1104324.P186_0566	7.062e-109	366.0	COG0045@1|root,arCOG01337@2157|Archaea,2XPUW@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMD2_k127_3232028_4	591019.Shell_0335	2.2e-108	357.0	COG0074@1|root,arCOG01339@2157|Archaea,2XPW3@28889|Crenarchaeota	28889|Crenarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA,Succ_CoA_lig
MMD2_k127_3232028_16	374847.Kcr_1397	7.24e-10	63.0	COG1552@1|root,arCOG04049@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMD2_k127_3232028_9	374847.Kcr_0663	1.325e-56	204.0	COG1852@1|root,arCOG02078@2157|Archaea	2157|Archaea	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
MMD2_k127_3232028_2	572546.Arcpr_0045	1.035e-119	393.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,246R1@183980|Archaeoglobi	183980|Archaeoglobi	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMD2_k127_3232028_15	589924.Ferp_1390	2.345e-12	70.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y6CP@28890|Euryarchaeota,247G4@183980|Archaeoglobi	183980|Archaeoglobi	J	RNA-binding protein involved in rRNA processing	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	-
MMD2_k127_3232028_14	1459636.NTE_01818	8.821e-21	96.0	arCOG05900@1|root,arCOG05900@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
MMD2_k127_3270122_5	1267535.KB906767_gene2367	8.603e-77	266.0	COG1063@1|root,COG1063@2|Bacteria,3Y30Y@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMD2_k127_3270122_6	907348.TresaDRAFT_2479	0.0001335	49.0	COG2816@1|root,COG2816@2|Bacteria,2J7EJ@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG2816 NTP pyrophosphohydrolase containing a Zn-finger probably nucleic-acid-binding	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,zf-NADH-PPase
MMD2_k127_3270122_2	1382306.JNIM01000001_gene2503	5.366e-92	313.0	COG1063@1|root,COG1063@2|Bacteria,2G8IZ@200795|Chloroflexi	200795|Chloroflexi	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMD2_k127_3270122_3	891968.Anamo_1259	3.84e-88	304.0	COG0508@1|root,COG0508@2|Bacteria,3TA12@508458|Synergistetes	508458|Synergistetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMD2_k127_3270122_0	891968.Anamo_1263	7.358e-129	420.0	COG0022@1|root,COG0022@2|Bacteria,3TA38@508458|Synergistetes	508458|Synergistetes	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMD2_k127_3270122_1	697303.Thewi_1630	1.172e-124	407.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMD2_k127_3270122_4	985053.VMUT_2055	1.95e-87	295.0	COG0012@1|root,arCOG00357@2157|Archaea,2XPTY@28889|Crenarchaeota	28889|Crenarchaeota	J	GTPase of	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
MMD2_k127_3330769_12	552811.Dehly_1029	1.907e-24	104.0	COG1592@1|root,COG4802@1|root,COG1592@2|Bacteria,COG4802@2|Bacteria,2GATJ@200795|Chloroflexi,34DB7@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
MMD2_k127_3330769_14	386456.JQKN01000001_gene2349	4.045e-17	84.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
MMD2_k127_3330769_15	1459636.NTE_02018	2.721e-11	75.0	COG0589@1|root,arCOG02053@2157|Archaea,41T7V@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMD2_k127_3330769_4	456442.Mboo_1503	7.04e-90	300.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,2NAEN@224756|Methanomicrobia	224756|Methanomicrobia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
MMD2_k127_3330769_10	1033806.HTIA_2652	2.22e-36	139.0	COG1146@1|root,arCOG04548@2157|Archaea,2XXXG@28890|Euryarchaeota,23W7X@183963|Halobacteria	183963|Halobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	ferB	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
MMD2_k127_3330769_13	436308.Nmar_0669	1.025e-19	91.0	COG0425@1|root,arCOG02062@2157|Archaea,41SU5@651137|Thaumarchaeota	651137|Thaumarchaeota	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	TusA
MMD2_k127_3330769_9	521011.Mpal_1671	2.131e-41	157.0	COG2044@1|root,arCOG02066@2157|Archaea,2XWA5@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM DsrE family protein	-	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07092	-	-	-	-	ko00000	-	-	-	DrsE,TusA
MMD2_k127_3330769_1	246194.CHY_2199	8.201e-133	439.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMD2_k127_3330769_7	555079.Toce_1131	3.158e-60	211.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,42GNH@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMD2_k127_3330769_8	868131.MSWAN_1475	1.616e-58	213.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,23P57@183925|Methanobacteria	183925|Methanobacteria	H	Biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
MMD2_k127_3330769_11	694440.JOMF01000005_gene198	3.526e-26	113.0	COG0760@1|root,arCOG07441@2157|Archaea	2157|Archaea	G	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
MMD2_k127_3330769_6	673860.AciM339_0429	1.004e-62	222.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,3F2M8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMD2_k127_3330769_3	1236689.MMALV_00370	1.187e-114	379.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,3F2I1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAB	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
MMD2_k127_3330769_0	565033.GACE_2122	1.287e-234	738.0	COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,246QD@183980|Archaeoglobi	183980|Archaeoglobi	C	succinate dehydrogenase or fumarate reductase, flavoprotein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMD2_k127_3330769_5	760568.Desku_1077	1.246e-80	288.0	COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,24BFV@186801|Clostridia,263RU@186807|Peptococcaceae	186801|Clostridia	C	PFAM Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMD2_k127_3330769_2	479434.Sthe_3386	1.895e-127	426.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi,27XT3@189775|Thermomicrobia	189775|Thermomicrobia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMD2_k127_3489904_2	665571.STHERM_c12740	3.898e-16	82.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
MMD2_k127_3489904_3	523841.HFX_1714	4.059e-12	76.0	COG2220@1|root,arCOG00515@2157|Archaea,2XSXY@28890|Euryarchaeota,23T4U@183963|Halobacteria	183963|Halobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactamase_B_2
MMD2_k127_3489904_0	591019.Shell_0951	6.818e-111	378.0	COG1530@1|root,arCOG00321@2157|Archaea,2XQ2D@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_3489904_1	1041930.Mtc_0290	7.779e-61	226.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_3629920_1	439481.Aboo_0717	2.213e-09	61.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y719@28890|Euryarchaeota,3F34W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD2_k127_3629920_0	111780.Sta7437_4112	8.029e-12	78.0	COG4932@1|root,COG4932@2|Bacteria,1GIGP@1117|Cyanobacteria,3VKF3@52604|Pleurocapsales	1117|Cyanobacteria	M	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
MMD2_k127_3638904_8	358681.BBR47_45580	1.114e-05	53.0	COG4932@1|root,COG4932@2|Bacteria,1UJQY@1239|Firmicutes,4ITDJ@91061|Bacilli,270X3@186822|Paenibacillaceae	91061|Bacilli	M	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
MMD2_k127_3638904_6	415426.Hbut_0892	7.056e-58	212.0	COG2413@1|root,arCOG04066@2157|Archaea,2XQ4I@28889|Crenarchaeota	28889|Crenarchaeota	S	DNA polymerase beta domain protein region	-	-	-	ko:K07073	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMD2_k127_3638904_4	1365176.N186_02405	6.83e-64	224.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMD2_k127_3638904_3	593117.TGAM_1098	6.283e-64	232.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,243CE@183968|Thermococci	183968|Thermococci	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMD2_k127_3638904_0	1232437.KL661978_gene3851	7.528e-313	972.0	COG2414@1|root,COG2414@2|Bacteria,1R76Y@1224|Proteobacteria,42QE3@68525|delta/epsilon subdivisions,2WIIW@28221|Deltaproteobacteria,2MIUU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMD2_k127_3638904_1	694429.Pyrfu_0295	2.932e-243	774.0	COG0417@1|root,arCOG00328@2157|Archaea,2XPM8@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM DNA polymerase (pol2)	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
MMD2_k127_3638904_2	186497.PF1725	9.695e-103	346.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMD2_k127_3638904_7	419665.Maeo_0661	4.443e-15	81.0	COG1658@1|root,arCOG01486@2157|Archaea,2XYTB@28890|Euryarchaeota,23R5F@183939|Methanococci	183939|Methanococci	L	SMART Toprim sub domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_4
MMD2_k127_3638904_5	604354.TSIB_0224	6.301e-63	222.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,242Y2@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMD2_k127_39320_2	192952.MM_0048	3.751e-158	506.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,2NA9G@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Aldehyde dehydrogenase	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMD2_k127_39320_25	342949.PNA2_1582	3.377e-33	138.0	COG0500@1|root,arCOG01773@2157|Archaea,2Y7UH@28890|Euryarchaeota,245KZ@183968|Thermococci	183968|Thermococci	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMD2_k127_39320_12	1041930.Mtc_0815	1.476e-65	231.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
MMD2_k127_39320_24	1094980.Mpsy_1791	2.556e-34	146.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,2N93V@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
MMD2_k127_39320_38	1459636.NTE_02170	1.142e-10	68.0	COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_39320_21	1459636.NTE_03146	3.631e-46	173.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMD2_k127_39320_20	351160.LRC424	1.336e-46	178.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
MMD2_k127_39320_22	386456.JQKN01000002_gene2740	1.263e-45	176.0	COG0483@1|root,arCOG01349@2157|Archaea,2Y87S@28890|Euryarchaeota,23PI8@183925|Methanobacteria	183925|Methanobacteria	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
MMD2_k127_39320_41	330779.Saci_0882	0.0001212	48.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMD2_k127_39320_33	694429.Pyrfu_0857	1.688e-19	93.0	arCOG04264@1|root,arCOG04264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_39320_39	591019.Shell_0971	1.99e-08	61.0	arCOG03871@1|root,arCOG03871@2157|Archaea,2XQZI@28889|Crenarchaeota	28889|Crenarchaeota	N	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_39320_19	694429.Pyrfu_1972	2.188e-48	177.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMD2_k127_39320_17	342949.PNA2_0223	9.515e-52	192.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,242UM@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
MMD2_k127_39320_16	415426.Hbut_0529	1.027e-53	194.0	COG0100@1|root,arCOG04240@2157|Archaea,2XQCR@28889|Crenarchaeota	28889|Crenarchaeota	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMD2_k127_39320_11	572546.Arcpr_1028	4.226e-66	234.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,246MA@183980|Archaeoglobi	183980|Archaeoglobi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,RNA_pol_A_bac,RNA_pol_L
MMD2_k127_39320_28	579137.Metvu_1633	8.356e-32	127.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,23R1N@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
MMD2_k127_39320_26	673860.AciM339_1029	8.72e-33	132.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,3F2SC@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMD2_k127_39320_23	877455.Metbo_0811	1.819e-42	159.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23PIA@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMD2_k127_39320_30	273063.STK_20635	1.099e-25	107.0	COG1644@1|root,arCOG04244@2157|Archaea,2XR60@28889|Crenarchaeota	28889|Crenarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008270,GO:0030880,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMD2_k127_39320_3	339860.Msp_0862	5.571e-136	444.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,23NP2@183925|Methanobacteria	183925|Methanobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMD2_k127_39320_10	1343739.PAP_01945	4.029e-71	248.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,242JS@183968|Thermococci	183968|Thermococci	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMD2_k127_39320_9	1220534.B655_1468	1.942e-83	287.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,23P13@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMD2_k127_39320_14	604354.TSIB_1226	1.425e-62	227.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2437V@183968|Thermococci	183968|Thermococci	F	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1901615	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMD2_k127_39320_15	224719.Abm4_1229	1.68e-54	201.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,23NXS@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD2_k127_39320_7	868131.MSWAN_1425	4.278e-105	352.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,23NQE@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
MMD2_k127_39320_8	374847.Kcr_1079	8.461e-84	290.0	COG0142@1|root,arCOG01726@2157|Archaea	2157|Archaea	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMD2_k127_39320_1	1343739.PAP_02340	4.366e-188	604.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,242MB@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMD2_k127_39320_35	453591.Igni_0768	2.991e-14	76.0	COG1400@1|root,arCOG01217@2157|Archaea,2XR4P@28889|Crenarchaeota	28889|Crenarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
MMD2_k127_39320_29	673860.AciM339_1543	2.232e-31	128.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,3F2SE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal protein S8e	rps8e	GO:0000462,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMD2_k127_39320_27	1459636.NTE_02061	4.361e-32	132.0	COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota	651137|Thaumarchaeota	K	segregation and condensation protein	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMD2_k127_39320_36	1459636.NTE_02062	5.515e-14	81.0	COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota	651137|Thaumarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	-
MMD2_k127_39320_4	69014.TK1017	8.025e-128	450.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,242QE@183968|Thermococci	183968|Thermococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMD2_k127_39320_34	386456.JQKN01000001_gene1962	8.189e-15	81.0	COG4010@1|root,arCOG04906@2157|Archaea,2XZ3A@28890|Euryarchaeota,23P5J@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized protein conserved in archaea (DUF2096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2096
MMD2_k127_39320_31	316067.Geob_1922	1.984e-25	112.0	COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,42SJF@68525|delta/epsilon subdivisions,2WP4X@28221|Deltaproteobacteria,43U8B@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMD2_k127_39320_13	1499967.BAYZ01000147_gene697	3.238e-65	226.0	COG1839@1|root,COG1839@2|Bacteria,2NPAQ@2323|unclassified Bacteria	2|Bacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
MMD2_k127_39320_18	1121405.dsmv_0775	2.306e-51	199.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
MMD2_k127_39320_6	373903.Hore_06890	1.791e-120	396.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,3WANK@53433|Halanaerobiales	186801|Clostridia	E	Thermophilic metalloprotease (M29)	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
MMD2_k127_39320_37	410358.Mlab_0190	1.597e-12	68.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
MMD2_k127_39320_0	1220534.B655_0941	4.065e-189	601.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
MMD2_k127_39320_32	234267.Acid_0813	8.955e-23	111.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMD2_k127_39320_40	647113.Metok_0449	6.349e-08	57.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,23RA3@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMD2_k127_39320_5	868131.MSWAN_0320	2.068e-127	419.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,23NWK@183925|Methanobacteria	183925|Methanobacteria	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMD2_k127_3990521_6	903814.ELI_2336	4.929e-06	52.0	COG1765@1|root,COG1765@2|Bacteria,1UKFU@1239|Firmicutes,25FW0@186801|Clostridia,25WI7@186806|Eubacteriaceae	186801|Clostridia	O	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
MMD2_k127_3990521_3	717606.PaecuDRAFT_0821	7.613e-36	145.0	COG0428@1|root,COG0428@2|Bacteria,1V1T7@1239|Firmicutes,4HG8N@91061|Bacilli,26Y9F@186822|Paenibacillaceae	91061|Bacilli	P	ZIP Zinc transporter	-	-	-	-	-	-	-	-	-	-	-	-	Zip
MMD2_k127_3990521_2	1459636.NTE_00252	3.421e-42	158.0	COG0599@1|root,arCOG02148@2157|Archaea	2157|Archaea	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMD2_k127_3990521_5	273057.SSO1898	1.808e-22	105.0	arCOG02703@1|root,arCOG02703@2157|Archaea,2XS5Q@28889|Crenarchaeota	28889|Crenarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMD2_k127_3990521_4	504472.Slin_0852	1.515e-30	129.0	arCOG09454@1|root,30G4A@2|Bacteria,4NPSB@976|Bacteroidetes,47Q9D@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_3990521_0	439481.Aboo_0868	2.19e-92	310.0	COG1028@1|root,arCOG01259@2157|Archaea,2XTYG@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMD2_k127_3990521_1	1449050.JNLE01000003_gene2228	1.856e-70	250.0	COG0697@1|root,COG0697@2|Bacteria,1UZ6C@1239|Firmicutes,24GY3@186801|Clostridia	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMD2_k127_401176_2	192952.MM_1177	2.303e-15	85.0	arCOG06759@1|root,arCOG06759@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMD2_k127_401176_0	515635.Dtur_0353	5.07e-82	286.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMD2_k127_401176_1	515635.Dtur_0352	5.556e-74	255.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	1.1.1.271,5.1.3.2,6.3.5.5	ko:K01784,ko:K01955,ko:K02377	ko00051,ko00052,ko00240,ko00250,ko00520,ko01100,map00051,map00052,map00240,map00250,map00520,map01100	M00051,M00361,M00362,M00632	R00256,R00291,R00575,R01395,R02984,R05692,R10948,R10949	RC00002,RC00010,RC00043,RC00289,RC01014,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMD2_k127_4109656_8	1229909.NSED_06010	6.427e-07	59.0	arCOG08737@1|root,arCOG08737@2157|Archaea,41T1W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4109656_6	1183377.Py04_0134	2.085e-08	64.0	COG1522@1|root,arCOG01581@2157|Archaea,2Y3C6@28890|Euryarchaeota,2442S@183968|Thermococci	183968|Thermococci	K	transcription regulator activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMD2_k127_4109656_4	1318628.MARLIPOL_10221	1.763e-10	67.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,467I2@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
MMD2_k127_4109656_2	1123376.AUIU01000015_gene439	7.981e-18	87.0	COG0640@1|root,COG0640@2|Bacteria,3J1BW@40117|Nitrospirae	40117|Nitrospirae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
MMD2_k127_4109656_0	580340.Tlie_1774	4.133e-87	299.0	COG0798@1|root,COG0798@2|Bacteria,3TC0V@508458|Synergistetes	508458|Synergistetes	P	PFAM Bile acid sodium symporter	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
MMD2_k127_4109656_11	545695.TREAZ_2535	8.387e-05	54.0	COG2006@1|root,COG2768@1|root,COG2006@2|Bacteria,COG2768@2|Bacteria,2J60I@203691|Spirochaetes	203691|Spirochaetes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
MMD2_k127_4109656_3	1235755.ANAM01000001_gene424	1.327e-16	93.0	COG0477@1|root,COG2814@2|Bacteria,1TRZK@1239|Firmicutes,4HBUJ@91061|Bacilli,4GYVD@90964|Staphylococcaceae	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	DUF3817,MFS_1,MFS_1_like,Sugar_tr
MMD2_k127_4109656_10	671065.MetMK1DRAFT_00024240	5.354e-06	55.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMD2_k127_4109656_5	671065.MetMK1DRAFT_00030780	1.61e-08	61.0	arCOG05900@1|root,arCOG05900@2157|Archaea,2XRDZ@28889|Crenarchaeota	28889|Crenarchaeota	K	regulatory protein, arsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,LexA_DNA_bind
MMD2_k127_4109656_13	439235.Dalk_2289	0.0002197	53.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1MWIT@1224|Proteobacteria,42W2M@68525|delta/epsilon subdivisions,2WRTW@28221|Deltaproteobacteria,2MKVR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	PKD,VCBS
MMD2_k127_4109656_9	316067.Geob_2648	8.254e-07	61.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,42NBT@68525|delta/epsilon subdivisions,2WKAW@28221|Deltaproteobacteria,43SD0@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	type II and III secretion system protein	pulQ	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N
MMD2_k127_4109656_7	1227487.C474_01232	1.46e-07	63.0	arCOG00381@1|root,arCOG00381@2157|Archaea,2XV5B@28890|Euryarchaeota,23T0B@183963|Halobacteria	183963|Halobacteria	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4109656_12	485916.Dtox_1961	0.0001383	51.0	COG3210@1|root,COG3656@1|root,COG5492@1|root,COG3210@2|Bacteria,COG3656@2|Bacteria,COG5492@2|Bacteria,1VUQN@1239|Firmicutes,24CDA@186801|Clostridia,267DX@186807|Peptococcaceae	186801|Clostridia	N	PFAM Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF4430,F5_F8_type_C,FIVAR,Flg_new,RHS_repeat,SH3_3,SLH,fn3
MMD2_k127_4109656_1	1041930.Mtc_2135	1.822e-31	131.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMD2_k127_4112373_0	1343739.PAP_00010	8.168e-116	387.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
MMD2_k127_4112373_1	593117.TGAM_0127	2.844e-92	322.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2430Y@183968|Thermococci	183968|Thermococci	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos
MMD2_k127_4112373_2	797299.HALLA_03475	4.199e-38	156.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUTD@28890|Euryarchaeota,23U9A@183963|Halobacteria	183963|Halobacteria	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMD2_k127_4120368_1	565033.GACE_1577	1.682e-40	155.0	COG4739@1|root,arCOG04483@2157|Archaea,2XYZT@28890|Euryarchaeota,24725@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148,FeS
MMD2_k127_4120368_2	743525.TSC_c03580	1.633e-36	142.0	COG3118@1|root,COG3118@2|Bacteria,1WK9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMD2_k127_4120368_4	1304284.L21TH_1659	4.719e-14	83.0	2CIJU@1|root,332RU@2|Bacteria,1VESI@1239|Firmicutes,24QR7@186801|Clostridia,36MZM@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1893)	-	-	-	-	-	-	-	-	-	-	-	-	TM1506
MMD2_k127_4120368_5	323259.Mhun_2082	1.842e-07	62.0	arCOG00764@1|root,arCOG00764@2157|Archaea,2Y49B@28890|Euryarchaeota,2NAZ2@224756|Methanomicrobia	224756|Methanomicrobia	C	formylmethanofuran dehydrogenase, subunit E	-	-	-	-	-	-	-	-	-	-	-	-	FmdE
MMD2_k127_4120368_0	868131.MSWAN_0860	1.55e-92	312.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,23NN6@183925|Methanobacteria	183925|Methanobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
MMD2_k127_4120368_3	342949.PNA2_0132	2.858e-15	78.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,24327@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMD2_k127_4167394_0	420247.Msm_0655	5.585e-104	348.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,23NRH@183925|Methanobacteria	183925|Methanobacteria	M	Bacterial transferase hexapeptide repeat	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMD2_k127_4167394_5	999630.TUZN_0224	4.739e-51	190.0	COG0592@1|root,arCOG00488@2157|Archaea,2XQCF@28889|Crenarchaeota	28889|Crenarchaeota	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
MMD2_k127_4167394_6	399550.Smar_0112	1.923e-46	176.0	COG0463@1|root,arCOG00895@2157|Archaea,2XSPD@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
MMD2_k127_4167394_8	330779.Saci_1920	5.66e-22	112.0	COG3463@1|root,arCOG03812@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
MMD2_k127_4167394_13	1097668.BYI23_A017870	7.94e-09	67.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VJ5X@28216|Betaproteobacteria,1K1CS@119060|Burkholderiaceae	28216|Betaproteobacteria	M	glycosyl transferase group 1	gtrA	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMD2_k127_4167394_14	555079.Toce_1588	2.147e-06	57.0	COG0438@1|root,COG0457@1|root,COG0463@1|root,COG2227@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0463@2|Bacteria,COG2227@2|Bacteria,1U9Z2@1239|Firmicutes,2494K@186801|Clostridia,42IVC@68295|Thermoanaerobacterales	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glycos_transf_1,Glycos_transf_2,Methyltransf_11,Methyltransf_25,TPR_8
MMD2_k127_4167394_1	330779.Saci_1904	8.097e-81	284.0	COG0438@1|root,arCOG01419@2157|Archaea,2XRYK@28889|Crenarchaeota	28889|Crenarchaeota	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMD2_k127_4167394_2	1365176.N186_04465	6.77e-73	260.0	COG1467@1|root,arCOG04110@2157|Archaea,2XQI5@28889|Crenarchaeota	28889|Crenarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMD2_k127_4167394_11	436308.Nmar_1789	4.482e-13	76.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
MMD2_k127_4167394_12	1459636.NTE_01676	4.931e-11	74.0	arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4167394_7	368408.Tpen_0644	8.603e-29	117.0	COG1631@1|root,arCOG04109@2157|Archaea,2XQU0@28889|Crenarchaeota	28889|Crenarchaeota	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMD2_k127_4167394_10	391623.TERMP_00374	9.667e-16	78.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,244JK@183968|Thermococci	183968|Thermococci	J	ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMD2_k127_4167394_3	644281.MFS40622_0994	2.428e-63	226.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,23PZU@183939|Methanococci	183939|Methanococci	J	Translation initiation factor 2	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMD2_k127_4167394_9	666510.ASAC_0202	5.235e-18	84.0	COG2260@1|root,arCOG00906@2157|Archaea,2XR3J@28889|Crenarchaeota	28889|Crenarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMD2_k127_4167394_4	1151117.AJLF01000001_gene1692	5.425e-53	196.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,242P6@183968|Thermococci	183968|Thermococci	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMD2_k127_4170061_7	748449.Halha_0541	8.478e-23	102.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3WB1K@53433|Halanaerobiales	186801|Clostridia	CI	Conserved carboxylase domain	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
MMD2_k127_4170061_11	1487921.DP68_04315	8.709e-15	81.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
MMD2_k127_4170061_8	485913.Krac_7071	9.068e-22	103.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMD2_k127_4170061_1	273068.TTE1217	1.832e-239	752.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,42FIA@68295|Thermoanaerobacterales	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMD2_k127_4170061_0	456442.Mboo_1285	2.018e-290	915.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD2_k127_4170061_15	264732.Moth_0723	0.0001428	50.0	COG1977@1|root,COG1977@2|Bacteria,1VMVU@1239|Firmicutes,24VHX@186801|Clostridia	186801|Clostridia	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
MMD2_k127_4170061_3	1183377.Py04_0946	1.866e-64	235.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,245DY@183968|Thermococci	183968|Thermococci	E	Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position	pepQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMD2_k127_4170061_16	693979.Bache_2671	0.0002535	50.0	COG3428@1|root,COG3428@2|Bacteria,4NWU0@976|Bacteroidetes,2FSBM@200643|Bacteroidia,4AQQX@815|Bacteroidaceae	976|Bacteroidetes	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
MMD2_k127_4170061_2	747365.Thena_1573	7.203e-121	407.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,42I85@68295|Thermoanaerobacterales	186801|Clostridia	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
MMD2_k127_4170061_13	1365176.N186_01600	1.939e-09	64.0	COG1449@1|root,arCOG03278@2157|Archaea,2XQ1R@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
MMD2_k127_4170061_4	673860.AciM339_1452	1.355e-63	230.0	COG0697@1|root,arCOG00272@2157|Archaea,2Y6Z7@28890|Euryarchaeota,3F2Z3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMD2_k127_4170061_12	273057.SSO5522	1.112e-10	64.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD2_k127_4170061_10	1211817.CCAT010000062_gene3855	6.088e-16	89.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23
MMD2_k127_4170061_14	247490.KSU1_B0163	4.166e-06	56.0	2DMNU@1|root,32SQH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4170061_6	351160.RRC119	3.312e-23	104.0	COG0607@1|root,arCOG02021@2157|Archaea,2Y14U@28890|Euryarchaeota,2NBC1@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
MMD2_k127_4170061_5	1459636.NTE_01649	1.485e-40	157.0	COG1280@1|root,arCOG01947@2157|Archaea,41T36@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Lysine exporter protein LysE YggA	-	-	-	-	-	-	-	-	-	-	-	-	LysE
MMD2_k127_4170061_9	1125863.JAFN01000001_gene1794	6.673e-17	83.0	arCOG10401@1|root,2ZA7Y@2|Bacteria,1R45R@1224|Proteobacteria,42MDG@68525|delta/epsilon subdivisions,2WKTC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4222783_4	255470.cbdbA1472	5.644e-10	66.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4222783_1	309799.DICTH_0189	5.77e-126	415.0	COG2461@1|root,COG2461@2|Bacteria	2|Bacteria	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
MMD2_k127_4222783_0	351160.RCIX2263	1.05e-170	547.0	COG0426@1|root,arCOG00509@2157|Archaea,2XSUD@28890|Euryarchaeota,2N90R@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Lactamase_B
MMD2_k127_4222783_2	374847.Kcr_1058	2.699e-19	93.0	COG2522@1|root,arCOG00017@2157|Archaea	2157|Archaea	S	Transcriptional regulator	-	-	-	ko:K07108,ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
MMD2_k127_4222783_3	1094980.Mpsy_0844	2.265e-11	64.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
MMD2_k127_4231661_5	386456.JQKN01000013_gene3059	7.817e-94	322.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,23NQR@183925|Methanobacteria	183925|Methanobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMD2_k127_4231661_11	694429.Pyrfu_0407	1.003e-32	134.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMD2_k127_4231661_12	1131266.ARWQ01000002_gene489	1.343e-19	90.0	COG1758@1|root,arCOG01268@2157|Archaea,41ST9@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	-	ko:K03014	ko00230,ko00240,ko01100,ko03020,ko04623,ko05016,ko05169,map00230,map00240,map01100,map03020,map04623,map05016,map05169	M00180,M00181,M00182	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
MMD2_k127_4231661_0	1459636.NTE_01192	5.903e-212	672.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMD2_k127_4231661_2	374847.Kcr_0665	1.203e-119	397.0	COG0498@1|root,arCOG01434@2157|Archaea	2157|Archaea	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC4	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMD2_k127_4231661_10	243232.MJ_0536	3.122e-45	169.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMD2_k127_4231661_6	1343739.PAP_05655	7.933e-77	266.0	COG1013@1|root,arCOG01599@2157|Archaea,2XUSE@28890|Euryarchaeota,2436C@183968|Thermococci	183968|Thermococci	C	ferredoxin oxidoreductase, subunit beta	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD2_k127_4231661_3	339860.Msp_1389	3.284e-118	391.0	COG0674@1|root,arCOG01607@2157|Archaea,2Y7K5@28890|Euryarchaeota,23NP4@183925|Methanobacteria	183925|Methanobacteria	C	ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMD2_k127_4231661_9	985053.VMUT_0382	1.86e-52	195.0	COG2086@1|root,arCOG00446@2157|Archaea,2XS2H@28889|Crenarchaeota	28889|Crenarchaeota	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMD2_k127_4231661_7	335543.Sfum_3929	1.382e-76	268.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42MH7@68525|delta/epsilon subdivisions,2WK12@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	iAF987.Gmet_2257	ETF,ETF_alpha
MMD2_k127_4231661_14	443598.AUFA01000007_gene4475	5.544e-17	93.0	COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,3JU19@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_01130	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMD2_k127_4231661_4	374847.Kcr_1036	2.626e-114	381.0	COG1960@1|root,arCOG04310@2157|Archaea	2157|Archaea	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMD2_k127_4231661_8	439235.Dalk_5067	3.549e-53	198.0	COG2048@1|root,COG2048@2|Bacteria,1RC7G@1224|Proteobacteria,43B85@68525|delta/epsilon subdivisions,2WMVG@28221|Deltaproteobacteria,2MJQR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	heterodisulfide reductase, subunit	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
MMD2_k127_4231661_13	304371.MCP_1578	3.274e-17	89.0	COG2048@1|root,arCOG00964@2157|Archaea,2XXYP@28890|Euryarchaeota,2N9VF@224756|Methanomicrobia	224756|Methanomicrobia	C	heterodisulfide reductase subunit C	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17,Fer4_8
MMD2_k127_4231661_1	868131.MSWAN_2320	5.89e-150	489.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23NUK@183925|Methanobacteria	183925|Methanobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD2_k127_4258213_0	269799.Gmet_3402	1.574e-94	321.0	COG0301@1|root,COG0301@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria,43T42@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Thiamine biosynthesis protein (ThiI)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
MMD2_k127_4258213_2	865861.AZSU01000005_gene934	1.348e-93	317.0	COG3386@1|root,COG3386@2|Bacteria,1UN4I@1239|Firmicutes,25GWC@186801|Clostridia,36Q09@31979|Clostridiaceae	186801|Clostridia	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4258213_15	198467.NP92_13990	0.0001194	53.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,21VQ0@150247|Anoxybacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMD2_k127_4258213_5	443143.GM18_2743	1.23e-69	250.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMD2_k127_4258213_1	386456.JQKN01000001_gene2139	7.852e-94	317.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD2_k127_4258213_4	693661.Arcve_1614	1.445e-83	291.0	COG0794@1|root,arCOG00068@2157|Archaea	693661.Arcve_1614|-	G	PFAM Sugar isomerase (SIS)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4258213_9	1183377.Py04_1490	7.4e-23	102.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
MMD2_k127_4258213_12	1198449.ACAM_0706	7.56e-11	66.0	COG1534@1|root,arCOG01346@2157|Archaea,2XRFX@28889|Crenarchaeota	28889|Crenarchaeota	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
MMD2_k127_4258213_7	591019.Shell_1393	1.637e-42	160.0	COG2238@1|root,arCOG01344@2157|Archaea,2XQKX@28889|Crenarchaeota	28889|Crenarchaeota	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMD2_k127_4258213_10	351160.RCIX1046	2.101e-21	98.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
MMD2_k127_4258213_13	1006006.Mcup_0603	8.232e-10	61.0	COG2167@1|root,arCOG04177@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMD2_k127_4258213_11	1131266.ARWQ01000004_gene1441	4.665e-14	79.0	COG2097@1|root,arCOG04473@2157|Archaea,41STQ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the ribosomal protein L31e family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
MMD2_k127_4258213_6	1183377.Py04_0570	3.292e-45	172.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,243II@183968|Thermococci	183968|Thermococci	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMD2_k127_4258213_14	1343739.PAP_04750	7.88e-09	59.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y0R1@28890|Euryarchaeota,244JC@183968|Thermococci	183968|Thermococci	J	rRNA binding	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
MMD2_k127_4258213_16	1054217.TALC_01571	0.0001577	50.0	COG1730@1|root,arCOG01341@2157|Archaea	2157|Archaea	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMD2_k127_4258213_3	272844.PAB2025	1.106e-92	313.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMD2_k127_4258213_8	1469245.JFBG01000083_gene220	3.483e-31	124.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales	135613|Chromatiales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMD2_k127_4289896_7	1111134.HMPREF1253_0935	1.061e-19	90.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
MMD2_k127_4289896_2	485916.Dtox_1967	1.271e-73	257.0	COG0488@1|root,COG0488@2|Bacteria,1UI2R@1239|Firmicutes,25EBF@186801|Clostridia,267CI@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter related	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
MMD2_k127_4289896_5	415426.Hbut_0577	3.895e-50	191.0	COG0618@1|root,arCOG01565@2157|Archaea,2XQUB@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
MMD2_k127_4289896_11	69014.TK0644	0.0005938	46.0	arCOG05854@1|root,arCOG05854@2157|Archaea,2Y45W@28890|Euryarchaeota,244I2@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF3194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3194
MMD2_k127_4289896_8	1459636.NTE_01347	6.866e-19	90.0	COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMD2_k127_4289896_9	868131.MSWAN_0466	9.533e-10	63.0	COG2892@1|root,arCOG04414@2157|Archaea,2Y1HA@28890|Euryarchaeota,23P8R@183925|Methanobacteria	183925|Methanobacteria	S	Transcription factor Pcc1	-	-	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
MMD2_k127_4289896_6	868131.MSWAN_0463	9.764e-21	96.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,23P4A@183925|Methanobacteria	183925|Methanobacteria	J	50S ribosomal protein L37Ae	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMD2_k127_4289896_1	529709.PYCH_03860	1.436e-80	276.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2433E@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMD2_k127_4289896_0	529709.PYCH_03850	1.167e-95	321.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMD2_k127_4289896_4	415426.Hbut_0570	3.662e-62	221.0	COG1097@1|root,arCOG00678@2157|Archaea,2XQE2@28889|Crenarchaeota	28889|Crenarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1,KH_6
MMD2_k127_4289896_3	1131266.ARWQ01000010_gene60	1.027e-67	237.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
MMD2_k127_4289896_10	554065.XP_005846778.1	1.032e-05	50.0	COG0638@1|root,KOG0178@2759|Eukaryota,37QI6@33090|Viridiplantae,34K66@3041|Chlorophyta	3041|Chlorophyta	O	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH	-	-	3.4.25.1	ko:K02728	ko03050,map03050	M00337,M00340	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMD2_k127_4318015_7	879212.DespoDRAFT_03531	2.101e-16	92.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,2MJ8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
MMD2_k127_4318015_2	102125.Xen7305DRAFT_00020850	8.764e-78	268.0	COG3823@1|root,COG3823@2|Bacteria,1GPV5@1117|Cyanobacteria,3VMFK@52604|Pleurocapsales	1117|Cyanobacteria	O	Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
MMD2_k127_4318015_1	877455.Metbo_0714	4.189e-127	422.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,Usp
MMD2_k127_4318015_0	368407.Memar_2430	6.557e-315	983.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	2157|Archaea	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4318015_5	1033810.HLPCO_002966	1.001e-28	126.0	2ESV0@1|root,33KDE@2|Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMD2_k127_4318015_3	485913.Krac_6553	2.024e-41	164.0	COG0500@1|root,COG2226@2|Bacteria,2G7FG@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMD2_k127_4318015_6	1197130.BAFM01000001_gene178	9.395e-21	98.0	COG1670@1|root,arCOG00842@2157|Archaea,2XVC6@28890|Euryarchaeota,23TBU@183963|Halobacteria	183963|Halobacteria	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	hat2	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMD2_k127_4318015_4	374847.Kcr_0785	3.977e-36	143.0	COG0589@1|root,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	Usp
MMD2_k127_4528780_24	269800.Tfu_2330	7.244e-05	48.0	COG3247@1|root,COG3247@2|Bacteria,2II04@201174|Actinobacteria,4EKMA@85012|Streptosporangiales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4528780_22	933801.Ahos_0782	3.243e-05	50.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMD2_k127_4528780_20	1184251.TCELL_0041	3.366e-06	57.0	COG0681@1|root,arCOG01739@2157|Archaea,2XQV6@28889|Crenarchaeota	28889|Crenarchaeota	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
MMD2_k127_4528780_18	453591.Igni_1396	6.463e-09	58.0	arCOG04323@1|root,arCOG04323@2157|Archaea,2XQVX@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4528780_3	1343739.PAP_06015	2.152e-128	425.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,243NV@183968|Thermococci	183968|Thermococci	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_4528780_4	272844.PAB1548	1.727e-113	381.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2435V@183968|Thermococci	183968|Thermococci	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMD2_k127_4528780_0	572478.Vdis_0925	3.511e-249	800.0	COG1201@1|root,arCOG00557@2157|Archaea,2XPNI@28889|Crenarchaeota	28889|Crenarchaeota	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMD2_k127_4528780_12	1365176.N186_02845	5.267e-48	177.0	COG0500@1|root,arCOG01631@2157|Archaea,2XQ7P@28889|Crenarchaeota	28889|Crenarchaeota	Q	RNA methylase	-	GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564	-	-	-	-	-	-	-	-	-	-	DOT1,Methyltransf_25,Methyltransf_31,PrmA
MMD2_k127_4528780_17	240016.ABIZ01000001_gene3142	1.115e-18	91.0	COG0824@1|root,COG0824@2|Bacteria,46VXK@74201|Verrucomicrobia,2IUVD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMD2_k127_4528780_16	589924.Ferp_2238	6.617e-23	104.0	COG0727@1|root,arCOG05059@2157|Archaea	2157|Archaea	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMD2_k127_4528780_15	523850.TON_1000	5.922e-30	129.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2436S@183968|Thermococci	183968|Thermococci	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMD2_k127_4528780_6	877455.Metbo_0645	8.614e-78	270.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,23NSZ@183925|Methanobacteria	183925|Methanobacteria	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMD2_k127_4528780_10	1220534.B655_0134	2.465e-54	205.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,23NJD@183925|Methanobacteria	183925|Methanobacteria	L	methylase	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
MMD2_k127_4528780_9	644281.MFS40622_0562	3.51e-59	215.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,23Q8A@183939|Methanococci	183939|Methanococci	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
MMD2_k127_4528780_2	1041930.Mtc_0274	6.524e-167	537.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota	28890|Euryarchaeota	I	Belongs to the HMG-CoA reductase family	hmgA-1	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
MMD2_k127_4528780_14	263820.PTO0637	7.051e-41	158.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,242AD@183967|Thermoplasmata	183967|Thermoplasmata	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
MMD2_k127_4528780_7	368407.Memar_0653	2.766e-70	248.0	COG0122@1|root,arCOG00464@2157|Archaea,2XU5Y@28890|Euryarchaeota,2N9M2@224756|Methanomicrobia	224756|Methanomicrobia	L	8-oxoguanine DNA glycosylase domain protein	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
MMD2_k127_4528780_1	399550.Smar_0866	1.013e-201	651.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMD2_k127_4528780_11	1229909.NSED_09550	8.373e-53	195.0	COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Ser thr protein kinase	-	-	-	ko:K07176	-	-	-	-	ko00000	-	-	-	RIO1
MMD2_k127_4528780_8	604354.TSIB_0059	2.634e-60	226.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,243DA@183968|Thermococci	183968|Thermococci	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
MMD2_k127_4528780_5	565033.GACE_0558	3.694e-105	351.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,246P6@183980|Archaeoglobi	183980|Archaeoglobi	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMD2_k127_4528780_13	693661.Arcve_1259	2.905e-46	172.0	COG0041@1|root,arCOG02464@2157|Archaea,2XX7E@28890|Euryarchaeota,24696@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMD2_k127_4528780_21	1120971.AUCA01000053_gene374	1.365e-05	53.0	COG1694@1|root,COG1694@2|Bacteria,1VG7F@1239|Firmicutes,4HWVH@91061|Bacilli	91061|Bacilli	S	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
MMD2_k127_4528780_19	1365176.N186_00260	7.353e-08	62.0	arCOG02216@1|root,arCOG02216@2157|Archaea,2XST0@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_46165_4	1163730.FFONT_0196	5.96e-79	273.0	COG2414@1|root,arCOG00706@2157|Archaea,2XPT1@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMD2_k127_46165_12	1235802.C823_02627	0.0008175	45.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,25USZ@186806|Eubacteriaceae	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
MMD2_k127_46165_0	1056495.Calag_0077	2.092e-234	738.0	COG2987@1|root,arCOG04670@2157|Archaea	2157|Archaea	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMD2_k127_46165_8	932678.THERU_02280	7.45e-66	230.0	COG1335@1|root,COG1335@2|Bacteria,2G3XJ@200783|Aquificae	200783|Aquificae	Q	Nicotinamidase	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
MMD2_k127_46165_10	444158.MmarC6_0782	1.25e-10	68.0	COG1695@1|root,arCOG00002@2157|Archaea,2Y1PS@28890|Euryarchaeota,23R7P@183939|Methanococci	183939|Methanococci	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
MMD2_k127_46165_6	386456.JQKN01000002_gene2793	1.104e-70	246.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota	28890|Euryarchaeota	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD2_k127_46165_5	186497.PF0933	3.257e-76	280.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,243PF@183968|Thermococci	183968|Thermococci	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
MMD2_k127_46165_2	857293.CAAU_0758	1.178e-115	383.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae	186801|Clostridia	E	aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
MMD2_k127_46165_7	399549.Msed_2164	2.21e-67	252.0	COG0433@1|root,arCOG00283@2157|Archaea	2157|Archaea	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMD2_k127_46165_11	1449343.JQLQ01000002_gene657	0.0005459	51.0	COG3393@1|root,COG3393@2|Bacteria,1UFJG@1239|Firmicutes,4HGNR@91061|Bacilli	91061|Bacilli	S	acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_10,Acetyltransf_9,GNAT_acetyltran
MMD2_k127_46165_3	633148.Tagg_0386	1.235e-114	378.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPQR@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD2_k127_46165_1	490899.DKAM_0579	1.295e-129	424.0	COG0674@1|root,arCOG01608@2157|Archaea,2XPUZ@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMD2_k127_4691369_0	1089553.Tph_c21490	2.844e-25	113.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	3.2.1.18	ko:K01186,ko:K20276	ko00511,ko00600,ko02024,ko04142,map00511,map00600,map02024,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Big_3_2,CHB_HEX_C_1,Laminin_G_3,NPCBM_assoc
MMD2_k127_4691369_1	1205910.B005_1056	1.762e-12	70.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
MMD2_k127_4749703_23	665571.STHERM_c21760	1.65e-10	64.0	COG0072@1|root,COG0072@2|Bacteria,2J63Q@203691|Spirochaetes	203691|Spirochaetes	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B5,tRNA-synt_2d,tRNA_bind
MMD2_k127_4749703_2	391623.TERMP_00405	2.235e-140	461.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,243HQ@183968|Thermococci	183968|Thermococci	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMD2_k127_4749703_3	1459636.NTE_01420	2.263e-135	441.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMD2_k127_4749703_12	436308.Nmar_0601	5.497e-72	253.0	COG0024@1|root,arCOG01001@2157|Archaea,41SEA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMD2_k127_4749703_24	694429.Pyrfu_0941	4.518e-06	54.0	arCOG03770@1|root,arCOG03770@2157|Archaea,2XR27@28889|Crenarchaeota	28889|Crenarchaeota	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4749703_8	1459636.NTE_02288	2.667e-92	316.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
MMD2_k127_4749703_7	1128421.JAGA01000002_gene1079	9.232e-99	334.0	COG2355@1|root,COG2355@2|Bacteria	2|Bacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	pvdM	-	3.4.13.19	ko:K01273,ko:K01274	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
MMD2_k127_4749703_22	591019.Shell_1144	8.735e-18	89.0	COG0517@1|root,arCOG00606@2157|Archaea,2XR8I@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMD2_k127_4749703_11	1122917.KB899660_gene1665	3.23e-81	286.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26RHJ@186822|Paenibacillaceae	91061|Bacilli	V	Multidrug ABC transporter, ATP-binding protein	yknV	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K02021,ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMD2_k127_4749703_19	1122917.KB899660_gene1665	1.827e-32	140.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26RHJ@186822|Paenibacillaceae	91061|Bacilli	V	Multidrug ABC transporter, ATP-binding protein	yknV	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	-	ko:K02021,ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMD2_k127_4749703_6	1382306.JNIM01000001_gene2617	4.711e-108	372.0	COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMD2_k127_4749703_21	1385512.N784_14350	9.941e-27	122.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HCS4@91061|Bacilli,2YB6H@289201|Pontibacillus	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMD2_k127_4749703_13	456442.Mboo_1043	3.971e-68	242.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	-	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
MMD2_k127_4749703_4	572478.Vdis_2439	1.86e-115	385.0	COG0001@1|root,arCOG00918@2157|Archaea,2XRMS@28889|Crenarchaeota	28889|Crenarchaeota	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMD2_k127_4749703_10	323259.Mhun_1311	5.322e-82	276.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota,2NBII@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMD2_k127_4749703_5	555079.Toce_0910	2.255e-113	376.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,42ESV@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMD2_k127_4749703_0	247490.KSU1_C1370	5.079e-252	791.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMD2_k127_4749703_20	138119.DSY3131	1.679e-29	124.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,26214@186807|Peptococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMD2_k127_4749703_1	589924.Ferp_1748	1.681e-167	546.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
MMD2_k127_4749703_16	309801.trd_1316	2.161e-45	184.0	COG0531@1|root,COG0531@2|Bacteria,2G76Z@200795|Chloroflexi	200795|Chloroflexi	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
MMD2_k127_4749703_9	1128421.JAGA01000003_gene3665	2.959e-92	312.0	COG2129@1|root,COG2129@2|Bacteria	2|Bacteria	L	metallophosphoesterase	-	-	-	ko:K07096,ko:K07496	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2,Metallophos_3
MMD2_k127_4749703_15	269797.Mbar_A1503	4.247e-50	185.0	COG5012@1|root,arCOG02028@2157|Archaea,2XX6R@28890|Euryarchaeota,2NA0S@224756|Methanomicrobia	224756|Methanomicrobia	S	Acts probably as a methyl group carrier between MttB and either MtbA or MtaA	-	-	-	ko:K14084	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124	RC00035,RC00732,RC02984	ko00000,ko00001,ko00002	-	-	iAF692.Mbar_A1503	B12-binding,B12-binding_2
MMD2_k127_4749703_18	913865.DOT_4723	6.999e-39	162.0	COG5598@1|root,COG5598@2|Bacteria,1UYBQ@1239|Firmicutes,249D7@186801|Clostridia,260FT@186807|Peptococcaceae	186801|Clostridia	H	PFAM Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
MMD2_k127_4749703_17	374847.Kcr_0806	5.039e-41	162.0	arCOG06048@1|root,arCOG06048@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4749703_14	632518.Calow_2148	4.602e-61	220.0	COG0407@1|root,COG0407@2|Bacteria,1UY51@1239|Firmicutes,24DZF@186801|Clostridia,42FW9@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
MMD2_k127_4845625_15	224325.AF_1767	4.305e-35	138.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,246Q1@183980|Archaeoglobi	183980|Archaeoglobi	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMD2_k127_4845625_4	944479.JQLX01000010_gene458	1.401e-90	310.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria,2M6DG@213113|Desulfurellales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMD2_k127_4845625_5	243274.THEMA_08575	5.394e-86	293.0	COG1173@1|root,COG1173@2|Bacteria,2GCC1@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMD2_k127_4845625_3	309803.CTN_1423	1.591e-97	328.0	COG0444@1|root,COG0444@2|Bacteria,2GC44@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMD2_k127_4845625_0	591019.Shell_0853	2.034e-120	394.0	COG4608@1|root,arCOG00184@2157|Archaea,2XQ0S@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter	dppF	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMD2_k127_4845625_17	1457250.BBMO01000002_gene2838	2.119e-18	99.0	arCOG02420@1|root,arCOG03991@1|root,arCOG02420@2157|Archaea,arCOG03991@2157|Archaea,2Y822@28890|Euryarchaeota	28890|Euryarchaeota	S	Archaeal Type IV pilin, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Pilin_N
MMD2_k127_4845625_19	309801.trd_1703	9.225e-12	78.0	COG1404@1|root,COG1572@1|root,COG1404@2|Bacteria,COG1572@2|Bacteria,2G8ZZ@200795|Chloroflexi,27YUT@189775|Thermomicrobia	189775|Thermomicrobia	O	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8
MMD2_k127_4845625_14	891968.Anamo_1976	9.906e-37	143.0	COG1786@1|root,COG1786@2|Bacteria,3TB4J@508458|Synergistetes	508458|Synergistetes	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
MMD2_k127_4845625_1	891968.Anamo_1977	6.044e-120	397.0	COG1679@1|root,COG1679@2|Bacteria,3TA66@508458|Synergistetes	508458|Synergistetes	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
MMD2_k127_4845625_6	269797.Mbar_A2220	1.526e-84	291.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9DW@224756|Methanomicrobia	224756|Methanomicrobia	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMD2_k127_4845625_20	39416.CAZ86480	1.219e-10	64.0	COG1958@1|root,KOG1783@2759|Eukaryota,3A5NM@33154|Opisthokonta,3P6ZD@4751|Fungi,3QXI3@4890|Ascomycota	4751|Fungi	A	Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4 U6 di-snRNP, spliceosomal U4 U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4 U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity)	LSM6	GO:0000375,GO:0000377,GO:0000398,GO:0000932,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005688,GO:0005730,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0022613,GO:0030490,GO:0030532,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0035770,GO:0036464,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045292,GO:0046483,GO:0046540,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097525,GO:0097526,GO:0120114,GO:0120115,GO:1901360,GO:1901363,GO:1990726,GO:1990904	-	ko:K12625	ko03018,ko03040,map03018,map03040	M00354,M00396,M00397	-	-	ko00000,ko00001,ko00002,ko03019,ko03041	-	-	-	LSM
MMD2_k127_4845625_10	694429.Pyrfu_0799	3.067e-69	246.0	COG0478@1|root,arCOG01181@2157|Archaea,2XPM0@28889|Crenarchaeota	28889|Crenarchaeota	T	RIO-like serine threonine protein kinase fused to N-terminal HTH domain	-	-	2.7.11.1	ko:K07179	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1,Rio2_N
MMD2_k127_4845625_8	868131.MSWAN_0865	3.393e-77	270.0	COG0122@1|root,arCOG00464@2157|Archaea,2XV7J@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMD2_k127_4845625_11	673860.AciM339_0266	1.859e-62	224.0	COG1235@1|root,arCOG00499@2157|Archaea,2XT48@28890|Euryarchaeota,3F2JB@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMD2_k127_4845625_12	573063.Metin_1084	1.092e-46	176.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,23Q4G@183939|Methanococci	183939|Methanococci	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMD2_k127_4845625_18	1459636.NTE_02413	3.614e-15	83.0	COG1695@1|root,arCOG00002@2157|Archaea,41SN8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
MMD2_k127_4845625_2	273063.STK_17720	1.781e-117	386.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPVP@28889|Crenarchaeota	28889|Crenarchaeota	V	TIGRFAM daunorubicin resistance ABC transporter ATPase subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD2_k127_4845625_7	273057.SSO2135	3.683e-82	284.0	COG0842@1|root,arCOG01467@2157|Archaea,2XQF4@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMD2_k127_4845625_9	926569.ANT_08780	4.226e-70	244.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMD2_k127_4845625_13	871968.DESME_13845	4.636e-42	170.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMD2_k127_4845625_16	204669.Acid345_1350	9.488e-32	128.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria,2JJTC@204432|Acidobacteriia	204432|Acidobacteriia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMD2_k127_4859325_6	644281.MFS40622_0209	2.479e-89	298.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD2_k127_4859325_5	868131.MSWAN_2076	5.062e-106	356.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria	183925|Methanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMD2_k127_4859325_23	1280689.AUJC01000001_gene2539	0.0003825	53.0	COG4193@1|root,COG4193@2|Bacteria,1UT0U@1239|Firmicutes,248R8@186801|Clostridia,36FFU@31979|Clostridiaceae	186801|Clostridia	G	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,CW_binding_2,ChW,Glucosaminidase,SLH
MMD2_k127_4859325_15	374847.Kcr_0680	1.063e-18	100.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,NosD
MMD2_k127_4859325_0	391623.TERMP_00992	3.698e-201	634.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMD2_k127_4859325_14	368408.Tpen_0838	2.022e-22	102.0	COG2164@1|root,arCOG04488@2157|Archaea	2157|Archaea	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
MMD2_k127_4859325_22	985053.VMUT_1669	0.0001122	49.0	COG4901@1|root,arCOG04327@2157|Archaea	2157|Archaea	J	30S ribosomal protein S25E	rps25e	-	-	ko:K02975	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S25
MMD2_k127_4859325_16	69014.TK1413	1.068e-14	76.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
MMD2_k127_4859325_11	1131266.ARWQ01000018_gene765	9.147e-34	140.0	COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
MMD2_k127_4859325_12	1131730.BAVI_16197	8.244e-30	134.0	COG0477@1|root,COG2814@2|Bacteria,1TSFM@1239|Firmicutes,4HABN@91061|Bacilli,1ZS92@1386|Bacillus	91061|Bacilli	EGP	COG0477 Permeases of the major facilitator superfamily	yqjV	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
MMD2_k127_4859325_13	660470.Theba_0404	8.953e-24	112.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMD2_k127_4859325_18	397948.Cmaq_0460	1.082e-11	68.0	COG1383@1|root,arCOG01885@2157|Archaea,2XR16@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
MMD2_k127_4859325_3	935948.KE386494_gene944	1.068e-137	449.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42EKB@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMD2_k127_4859325_1	1487923.DP73_14965	7.59e-154	494.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25ZZ5@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMD2_k127_4859325_2	374847.Kcr_1548	2.074e-140	454.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMD2_k127_4859325_4	237368.SCABRO_03312	2.203e-118	394.0	COG2379@1|root,COG2379@2|Bacteria,2IXJ2@203682|Planctomycetes	203682|Planctomycetes	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMD2_k127_4859325_19	706587.Desti_5526	9.374e-10	59.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2MQ9G@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	MOFRL family	Glyctk	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMD2_k127_4859325_21	384616.Pisl_0947	2.731e-05	51.0	COG1977@1|root,arCOG00536@2157|Archaea,2XRHB@28889|Crenarchaeota	28889|Crenarchaeota	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
MMD2_k127_4859325_8	374847.Kcr_0835	5.122e-55	201.0	COG1478@1|root,arCOG02714@2157|Archaea	2157|Archaea	E	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	GO:0003674,GO:0003824,GO:0016874,GO:0016879,GO:0016881,GO:0052618	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
MMD2_k127_4859325_20	1094980.Mpsy_2167	2.338e-05	55.0	arCOG06562@1|root,arCOG06562@2157|Archaea,2Y5QT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4859325_7	269797.Mbar_A0603	8.102e-60	216.0	COG1912@1|root,arCOG04309@2157|Archaea,2XUEW@28890|Euryarchaeota,2N9T8@224756|Methanomicrobia	224756|Methanomicrobia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
MMD2_k127_4859325_9	565033.GACE_1585	4.356e-53	192.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,246YM@183980|Archaeoglobi	183980|Archaeoglobi	F	Nicotinamide-nucleotide adenylyltransferase	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMD2_k127_4859325_17	439235.Dalk_4378	1.39e-14	81.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria,2MKVU@213118|Desulfobacterales	28221|Deltaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
MMD2_k127_4859325_10	1365176.N186_02605	1.305e-35	148.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
MMD2_k127_4913257_7	1047013.AQSP01000095_gene2313	1.815e-82	284.0	COG3804@1|root,COG3804@2|Bacteria,2NP85@2323|unclassified Bacteria	2|Bacteria	S	dihydrodipicolinate reductase	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.16,1.4.1.26	ko:K03340,ko:K21672	ko00300,ko00310,ko00330,ko00472,ko01100,ko01110,ko01230,map00300,map00310,map00330,map00472,map01100,map01110,map01230	M00526	R02755,R02825,R04200,R04201,R04687,R04688	RC00006,RC00249,RC00790	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N
MMD2_k127_4913257_5	1449126.JQKL01000011_gene3549	2.536e-94	327.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,267YC@186813|unclassified Clostridiales	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,NAD_binding_8,Pyr_redox_2
MMD2_k127_4913257_0	706587.Desti_0010	0.0	1109.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1QUMN@1224|Proteobacteria,43BMA@68525|delta/epsilon subdivisions,2X6ZG@28221|Deltaproteobacteria,2MR5E@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NAD(P)-binding Rossmann-like domain	hdrA	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7,FlpD,Pyr_redox_2
MMD2_k127_4913257_21	439235.Dalk_1630	3.394e-25	107.0	COG1146@1|root,COG1146@2|Bacteria,1N0QV@1224|Proteobacteria,42U2Z@68525|delta/epsilon subdivisions,2WR58@28221|Deltaproteobacteria,2MM2N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
MMD2_k127_4913257_2	706587.Desti_0013	3.785e-141	458.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria,2MRFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ferredoxin oxidoreductase, alpha subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMD2_k127_4913257_4	234267.Acid_6989	1.68e-104	346.0	COG1013@1|root,COG1013@2|Bacteria,3Y514@57723|Acidobacteria	57723|Acidobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMD2_k127_4913257_14	426368.MmarC7_0560	2.032e-55	199.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMD2_k127_4913257_13	391623.TERMP_00899	6.379e-56	201.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,242YU@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
MMD2_k127_4913257_1	351160.LRC224	9.544e-151	488.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,2NADB@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMD2_k127_4913257_23	1183377.Py04_0132	2.87e-15	78.0	arCOG01354@1|root,arCOG01354@2157|Archaea,2Y4NI@28890|Euryarchaeota,244GV@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4913257_6	439481.Aboo_1116	3.838e-94	326.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,3F2FV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	DHHA1 domain	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
MMD2_k127_4913257_17	1365176.N186_03535	7.324e-42	158.0	COG0184@1|root,arCOG04185@2157|Archaea,2XQ88@28889|Crenarchaeota	28889|Crenarchaeota	J	ribosomal protein S15	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMD2_k127_4913257_19	439481.Aboo_0753	1.08e-28	132.0	COG1215@1|root,arCOG01391@2157|Archaea,2XYDG@28890|Euryarchaeota,3F2WW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3,Glyco_trans_2_3
MMD2_k127_4913257_24	768706.Desor_3591	2.34e-12	73.0	COG2318@1|root,COG2318@2|Bacteria,1V51W@1239|Firmicutes	1239|Firmicutes	S	DinB family	dinB	-	-	-	-	-	-	-	-	-	-	-	DinB
MMD2_k127_4913257_16	436308.Nmar_1530	1.385e-45	171.0	COG0127@1|root,arCOG04184@2157|Archaea,41SKW@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the HAM1 NTPase family	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMD2_k127_4913257_10	70601.3256848	1.145e-60	216.0	COG0533@1|root,arCOG01185@2157|Archaea,2XX5D@28890|Euryarchaeota,2436E@183968|Thermococci	183968|Thermococci	T	serine threonine protein kinase	-	GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	RIO1
MMD2_k127_4913257_3	868131.MSWAN_2418	4.162e-114	377.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,23NPI@183925|Methanobacteria	183925|Methanobacteria	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Peptidase_M22,Pkinase,RIO1
MMD2_k127_4913257_18	509191.AEDB02000094_gene4169	1.099e-37	145.0	COG1670@1|root,COG5646@1|root,COG1670@2|Bacteria,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,24K4J@186801|Clostridia,3WKGY@541000|Ruminococcaceae	186801|Clostridia	J	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
MMD2_k127_4913257_22	1459636.NTE_00647	5.787e-24	106.0	COG1522@1|root,arCOG04153@2157|Archaea,41SP6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4913257_12	243232.MJ_1376	5.941e-57	205.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,23QIM@183939|Methanococci	183939|Methanococci	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMD2_k127_4913257_20	1183377.Py04_0142	8.273e-26	115.0	arCOG05719@1|root,arCOG05719@2157|Archaea,2Y2UN@28890|Euryarchaeota,2434Z@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF4152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4152
MMD2_k127_4913257_26	1229909.NSED_09650	3.938e-09	64.0	arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
MMD2_k127_4913257_8	877455.Metbo_0646	7.713e-78	271.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,23NNA@183925|Methanobacteria	183925|Methanobacteria	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
MMD2_k127_4913257_15	1459636.NTE_01749	4.082e-49	190.0	COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_4913257_9	593117.TGAM_1450	2.134e-61	219.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,242T1@183968|Thermococci	183968|Thermococci	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMD2_k127_4913257_11	1459636.NTE_01899	1.606e-60	216.0	COG0638@1|root,arCOG00970@2157|Archaea,41SGS@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMD2_k127_4913257_25	1365176.N186_02605	1.173e-10	66.0	COG2234@1|root,arCOG02959@2157|Archaea	2157|Archaea	S	Peptidase M28	ywaD2	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
MMD2_k127_4958833_1	351160.RRC90	3.037e-49	179.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD2_k127_4958833_2	693661.Arcve_0993	1.588e-42	174.0	COG0383@1|root,arCOG03661@2157|Archaea,2XVNX@28890|Euryarchaeota	28890|Euryarchaeota	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
MMD2_k127_4958833_0	160799.PBOR_09175	1.3e-56	211.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,26VD8@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD2_k127_5023729_15	634497.HAH_2136	7.581e-09	59.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,23VUR@183963|Halobacteria	183963|Halobacteria	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
MMD2_k127_5023729_5	195522.BD01_2168	3.594e-58	209.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,243VI@183968|Thermococci	183968|Thermococci	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18_c,Ribosomal_L5e
MMD2_k127_5023729_3	1163730.FFONT_0500	1.211e-78	268.0	COG0098@1|root,arCOG04087@2157|Archaea,2XPK9@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S12 plays an important role in translational accuracy	rps5	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMD2_k127_5023729_7	391623.TERMP_00113	1.326e-38	149.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,243IZ@183968|Thermococci	183968|Thermococci	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMD2_k127_5023729_13	933801.Ahos_2218	2.162e-12	73.0	COG0071@1|root,arCOG08402@1|root,arCOG01833@2157|Archaea,arCOG08402@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMD2_k127_5023729_10	368408.Tpen_0234	1.693e-29	122.0	COG0200@1|root,arCOG00779@2157|Archaea,2XQH0@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMD2_k127_5023729_1	1459636.NTE_02794	6.227e-117	392.0	COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota	651137|Thaumarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
MMD2_k127_5023729_8	1229909.NSED_01950	3.784e-36	145.0	COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
MMD2_k127_5023729_17	386456.JQKN01000001_gene1737	2.655e-05	53.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,23P4B@183925|Methanobacteria	183925|Methanobacteria	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
MMD2_k127_5023729_18	7217.FBpp0121410	7.574e-05	48.0	COG2174@1|root,KOG1790@2759|Eukaryota,3A4A9@33154|Opisthokonta,3BSMR@33208|Metazoa,3D74P@33213|Bilateria,41ZE8@6656|Arthropoda,3SMS6@50557|Insecta,453FM@7147|Diptera,45TY3@7214|Drosophilidae	33208|Metazoa	J	Structural constituent of ribosome. It is involved in the biological process described with translation	RPL34	GO:0000184,GO:0000956,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006413,GO:0006518,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006725,GO:0006807,GO:0006810,GO:0006886,GO:0008092,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0015031,GO:0015833,GO:0015934,GO:0016070,GO:0016071,GO:0017022,GO:0019222,GO:0019439,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0034641,GO:0034645,GO:0034655,GO:0042254,GO:0042886,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045047,GO:0045184,GO:0046483,GO:0046700,GO:0046907,GO:0048519,GO:0050789,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060255,GO:0065007,GO:0070727,GO:0070972,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1990904	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
MMD2_k127_5023729_6	1229909.NSED_01960	2.229e-39	153.0	COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMD2_k127_5023729_11	273063.STK_24120	1.558e-27	125.0	COG0535@1|root,arCOG00938@2157|Archaea	2157|Archaea	P	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Radical_SAM,SPASM
MMD2_k127_5023729_12	384616.Pisl_1468	1.04e-20	101.0	COG0463@1|root,arCOG01381@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
MMD2_k127_5023729_2	1343739.PAP_02960	2.962e-94	320.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTX2@28890|Euryarchaeota,242XP@183968|Thermococci	183968|Thermococci	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
MMD2_k127_5023729_9	1343739.PAP_04395	3.959e-31	129.0	COG4720@1|root,arCOG05752@2157|Archaea,2XYJ2@28890|Euryarchaeota,243PD@183968|Thermococci	183968|Thermococci	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
MMD2_k127_5023729_0	272844.PAB2002	2.265e-150	494.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,242VY@183968|Thermococci	183968|Thermococci	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMD2_k127_5023729_4	877455.Metbo_1208	5.244e-64	232.0	COG0476@1|root,arCOG09483@1|root,arCOG01676@2157|Archaea,arCOG09483@2157|Archaea,2XTYV@28890|Euryarchaeota	28890|Euryarchaeota	H	UBA THIF-type NAD FAD binding protein	-	-	2.7.7.73,2.7.7.80	ko:K03148,ko:K21029	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	TBP,ThiF
MMD2_k127_5023729_16	589924.Ferp_0866	2.467e-08	64.0	arCOG07522@1|root,arCOG07522@2157|Archaea,2Y1I3@28890|Euryarchaeota,247FV@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_5023729_14	985053.VMUT_0271	2.076e-10	70.0	arCOG01214@1|root,arCOG01214@2157|Archaea,2XR4Q@28889|Crenarchaeota	28889|Crenarchaeota	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,Trehalose_PPase
MMD2_k127_5037993_2	1168289.AJKI01000002_gene2232	1.893e-07	61.0	COG1377@1|root,COG1377@2|Bacteria,4NMN3@976|Bacteroidetes,2FUW1@200643|Bacteroidia,3XIPA@558415|Marinilabiliaceae	976|Bacteroidetes	NU	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_5037993_0	865861.AZSU01000002_gene2357	2.731e-23	101.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,36E3H@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMD2_k127_5108896_7	521011.Mpal_1810	0.0003927	49.0	COG3291@1|root,arCOG02554@1|root,arCOG02559@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02554@2157|Archaea,arCOG02559@2157|Archaea,2Y7Y8@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
MMD2_k127_5108896_6	500153.JOEK01000001_gene3946	1.083e-05	51.0	28VA1@1|root,2ZHCY@2|Bacteria,2INFH@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
MMD2_k127_5108896_3	269799.Gmet_0682	1.889e-15	87.0	COG0454@1|root,COG0456@2|Bacteria,1QWS7@1224|Proteobacteria,43C57@68525|delta/epsilon subdivisions,2X7FK@28221|Deltaproteobacteria,43UVD@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD2_k127_5108896_1	1229909.NSED_01550	5.657e-59	210.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMD2_k127_5108896_0	877455.Metbo_0981	1.182e-117	395.0	COG0281@1|root,arCOG01331@2157|Archaea	2157|Archaea	C	Zn-dependent protease with chaperone function	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
MMD2_k127_5108896_4	765912.Thimo_1125	6.868e-15	78.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Ferric_reduct,Rieske,Rieske_2
MMD2_k127_5108896_5	342949.PNA2_0870	2.275e-09	67.0	COG1011@1|root,arCOG02291@2157|Archaea,2XWYR@28890|Euryarchaeota,243P8@183968|Thermococci	183968|Thermococci	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMD2_k127_5108896_2	1151117.AJLF01000001_gene1091	3.646e-20	93.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMD2_k127_5330116_1	644281.MFS40622_0209	4.584e-119	390.0	COG1148@1|root,arCOG02235@2157|Archaea,2XT3X@28890|Euryarchaeota,23QA9@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Pyr_redox_2
MMD2_k127_5330116_0	1121933.AUHH01000032_gene1957	5.587e-167	532.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4DP86@85009|Propionibacteriales	201174|Actinobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMD2_k127_5468713_3	1410632.JHWW01000002_gene2159	6.062e-17	83.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMD2_k127_5468713_4	518766.Rmar_0824	2.112e-11	71.0	COG0438@1|root,COG0438@2|Bacteria,4NSYG@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD2_k127_5468713_5	398512.JQKC01000022_gene3593	3.203e-06	61.0	COG5297@1|root,COG5297@2|Bacteria,1UZ2F@1239|Firmicutes,248N0@186801|Clostridia,3WGXQ@541000|Ruminococcaceae	186801|Clostridia	G	hydrolase family 9	celK	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_4_9,CelD_N,Dockerin_1,Glyco_hydro_9
MMD2_k127_5468713_0	1365176.N186_07225	1.595e-60	219.0	COG0677@1|root,arCOG00252@2157|Archaea,2XRM4@28889|Crenarchaeota	28889|Crenarchaeota	M	GDP-mannose dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	UDPG_MGDP_dh
MMD2_k127_5468713_2	415426.Hbut_1414	1.559e-32	134.0	COG0110@1|root,arCOG01848@2157|Archaea,2XQEI@28889|Crenarchaeota	28889|Crenarchaeota	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
MMD2_k127_5468713_1	419665.Maeo_0844	6.223e-40	161.0	COG1817@1|root,arCOG01395@2157|Archaea,2XT3W@28890|Euryarchaeota,23QB8@183939|Methanococci	183939|Methanococci	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
MMD2_k127_5469692_1	1184251.TCELL_0980	3.555e-08	61.0	COG1522@1|root,arCOG01580@2157|Archaea,2XQKA@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMD2_k127_5469692_2	555088.DealDRAFT_0407	1.419e-06	58.0	COG2944@1|root,COG4728@1|root,COG2944@2|Bacteria,COG4728@2|Bacteria	2|Bacteria	FJ	Protein conserved in bacteria	-	-	3.2.2.10	ko:K06966,ko:K07726,ko:K09004,ko:K13655	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000,ko02048,ko03000	-	-	-	DUF1653
MMD2_k127_5469692_0	1365176.N186_02250	3.198e-100	331.0	COG1690@1|root,arCOG04246@2157|Archaea,2XPMA@28889|Crenarchaeota	28889|Crenarchaeota	L	Belongs to the RtcB family	rtcB	GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
MMD2_k127_5543428_1	572478.Vdis_1831	3.33e-34	142.0	arCOG01214@1|root,arCOG01214@2157|Archaea,2XR4Q@28889|Crenarchaeota	28889|Crenarchaeota	S	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3,Trehalose_PPase
MMD2_k127_5543428_0	572478.Vdis_0423	2.659e-133	445.0	arCOG05497@1|root,arCOG05497@2157|Archaea,2XPW7@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMD2_k127_5543428_2	436308.Nmar_1020	4.304e-06	54.0	arCOG08737@1|root,arCOG08737@2157|Archaea,41T1W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_5639096_1	1459636.NTE_00007	8.833e-139	458.0	COG0417@1|root,arCOG00329@2157|Archaea	2157|Archaea	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
MMD2_k127_5639096_3	368408.Tpen_1222	4.566e-90	306.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPRD@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMD2_k127_5639096_10	1365176.N186_07280	5.51e-44	170.0	COG0842@1|root,arCOG01467@2157|Archaea,2XQAJ@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMD2_k127_5639096_11	1365176.N186_07285	7.212e-43	168.0	COG0842@1|root,arCOG01467@2157|Archaea,2XPZ5@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMD2_k127_5639096_2	747365.Thena_1426	9.162e-91	316.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,42FXS@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
MMD2_k127_5639096_16	595460.RRSWK_02274	0.0006967	52.0	COG0515@1|root,COG0515@2|Bacteria,2IX48@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMD2_k127_5639096_5	368408.Tpen_0138	4.191e-83	289.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMD2_k127_5639096_13	289377.HL41_06210	1.161e-18	97.0	COG1801@1|root,COG1801@2|Bacteria,2GH84@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMD2_k127_5639096_14	13035.Dacsa_2871	2.203e-07	57.0	COG0737@1|root,COG2931@1|root,COG0737@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HemolysinCabind
MMD2_k127_5639096_0	1499967.BAYZ01000180_gene4413	2.035e-164	527.0	28IMC@1|root,2Z8MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_5639096_15	1459636.NTE_02680	6.295e-07	55.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMD2_k127_5639096_8	1041930.Mtc_0466	1.676e-62	234.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMD2_k127_5639096_12	589924.Ferp_1735	1.108e-41	171.0	COG0269@1|root,arCOG00104@2157|Archaea	2157|Archaea	G	Formaldehyde-activating enzyme (Fae)	-	-	4.2.1.147	ko:K10713	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R08058	RC01583,RC01795	ko00000,ko00001,ko01000	-	-	-	Fae
MMD2_k127_5639096_9	604354.TSIB_0929	7.417e-61	219.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,2439X@183968|Thermococci	183968|Thermococci	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
MMD2_k127_5639096_4	633148.Tagg_0182	1.327e-88	306.0	COG1163@1|root,arCOG00358@2157|Archaea,2XPR5@28889|Crenarchaeota	28889|Crenarchaeota	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
MMD2_k127_5639096_6	415426.Hbut_1580	3.404e-72	250.0	COG0049@1|root,arCOG04254@2157|Archaea,2XPUU@28889|Crenarchaeota	28889|Crenarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMD2_k127_5639096_7	415426.Hbut_1578	9.473e-63	219.0	COG0048@1|root,arCOG04255@2157|Archaea,2XQ79@28889|Crenarchaeota	28889|Crenarchaeota	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMD2_k127_70351_0	374847.Kcr_1093	1.241e-82	306.0	COG0747@1|root,arCOG01534@2157|Archaea	2157|Archaea	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMD2_k127_70351_2	263820.PTO0762	1.409e-35	145.0	arCOG06964@1|root,arCOG06964@2157|Archaea	2157|Archaea	S	Peptidase A4 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A4
MMD2_k127_70351_1	1379698.RBG1_1C00001G0621	2.863e-42	160.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,HTH_18,Rhodanese
MMD2_k127_70351_3	1454004.AW11_02086	4.276e-23	106.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,1KR3X@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
MMD2_k127_70351_5	1116369.KB890024_gene3250	2.617e-06	53.0	COG4274@1|root,COG4274@2|Bacteria,1RHJ3@1224|Proteobacteria,2U9XS@28211|Alphaproteobacteria,43PYA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
MMD2_k127_70351_4	1324957.K933_09993	5.059e-10	63.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT6J@28890|Euryarchaeota,23SDS@183963|Halobacteria	183963|Halobacteria	H	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	RimK,Zn_protease
MMD2_k127_840526_10	756883.Halar_3098	2.342e-51	195.0	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMD2_k127_840526_5	459349.CLOAM0164	2.629e-76	290.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
MMD2_k127_840526_19	1220534.B655_1048	6.653e-06	60.0	arCOG02499@1|root,arCOG02501@1|root,arCOG02499@2157|Archaea,arCOG02501@2157|Archaea,2Y0FJ@28890|Euryarchaeota	28890|Euryarchaeota	O	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD
MMD2_k127_840526_14	1051632.TPY_3219	3.793e-32	135.0	2DGGT@1|root,2ZVX8@2|Bacteria,1V6AM@1239|Firmicutes	1239|Firmicutes	S	Peptidase A4 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A4
MMD2_k127_840526_12	868131.MSWAN_0387	6.025e-38	149.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota	28890|Euryarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMD2_k127_840526_15	304371.MCP_0666	1.099e-31	131.0	COG2431@1|root,arCOG01615@2157|Archaea,2XXIP@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
MMD2_k127_840526_2	415426.Hbut_0840	9.772e-230	733.0	COG0480@1|root,arCOG01559@2157|Archaea,2XPV5@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMD2_k127_840526_1	858215.Thexy_0923	1.663e-252	808.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
MMD2_k127_840526_7	70601.3257797	3.93e-55	204.0	COG0144@1|root,arCOG00973@2157|Archaea,2XUFZ@28890|Euryarchaeota,2438X@183968|Thermococci	183968|Thermococci	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N
MMD2_k127_840526_18	604354.TSIB_1805	2.371e-06	57.0	COG1374@1|root,arCOG00993@2157|Archaea,2XY2S@28890|Euryarchaeota,2441W@183968|Thermococci	183968|Thermococci	J	Uncharacterised protein family (UPF0113)	-	-	-	ko:K07565	-	-	-	-	ko00000,ko03009	-	-	-	UPF0113
MMD2_k127_840526_16	573063.Metin_0479	6.15e-14	75.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,23Q2X@183939|Methanococci	183939|Methanococci	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMD2_k127_840526_4	243232.MJ_1000	8.301e-83	286.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,23Q2X@183939|Methanococci	183939|Methanococci	J	PFAM tRNA synthetase, class II (G, H, P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMD2_k127_840526_13	1459636.NTE_01681	3.55e-33	135.0	COG1676@1|root,arCOG01701@2157|Archaea,41SJY@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
MMD2_k127_840526_3	1304880.JAGB01000001_gene848	1.067e-105	353.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,249C5@186801|Clostridia	186801|Clostridia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
MMD2_k127_840526_9	1343739.PAP_04075	1.068e-51	192.0	COG0503@1|root,arCOG00031@2157|Archaea,2XTD2@28890|Euryarchaeota,242RK@183968|Thermococci	183968|Thermococci	F	Phosphoribosyl transferase domain	-	-	2.4.2.7	ko:K00759,ko:K09685	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko03000,ko04147	-	-	-	HTH_3,Pribosyltran
MMD2_k127_840526_0	1459636.NTE_01284	7.115e-321	1009.0	COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMD2_k127_840526_8	1519464.HY22_09445	4.65e-53	196.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMD2_k127_840526_11	468556.AQYG01000045_gene1790	8.144e-45	180.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,2GJPX@201174|Actinobacteria,4GAV6@85026|Gordoniaceae	201174|Actinobacteria	L	ATP dependent DNA ligase C terminal region	ligD	GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
MMD2_k127_840526_6	531844.FIC_00895	3.836e-59	222.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1HYT4@117743|Flavobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
MMD2_k127_882012_3	368408.Tpen_1767	3.402e-18	96.0	arCOG02216@1|root,arCOG02216@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_882012_4	304371.MCP_2089	1.635e-07	57.0	arCOG09498@1|root,arCOG09498@2157|Archaea,2Y5MP@28890|Euryarchaeota,2NBCR@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMD2_k127_882012_1	456442.Mboo_0428	6.015e-61	218.0	COG2041@1|root,arCOG00266@2157|Archaea,2Y690@28890|Euryarchaeota,2NAWR@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
MMD2_k127_882012_2	1236976.JCM16418_3629	1.558e-52	194.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,4HJIN@91061|Bacilli,26RB8@186822|Paenibacillaceae	91061|Bacilli	-	-	M1-693	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
MMD2_k127_882012_0	351160.RCIX1328	4.551e-110	366.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase, group 1	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMD2_k127_960498_0	416591.Tlet_1813	1.721e-32	129.0	COG0454@1|root,COG0456@2|Bacteria,2GDPE@200918|Thermotogae	200918|Thermotogae	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMD2_k127_960498_1	1094980.Mpsy_2536	1.31e-15	76.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
## 904 queries scanned
## Total time (seconds): 86.78867435455322
## Rate: 10.42 q/s