## Fri Nov 15 09:35:01 2024 ## emapper-2.1.12 ## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin16/MMS_1_bin.112.fa -m mmseqs --itype genome -o MMS_1_bin.112 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_1_bin.112 --cpu 28 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs MMS1_k127_1017070_2 1229780.BN381_80217 1.322e-62 226.0 COG1946@1|root,COG1946@2|Bacteria 2|Bacteria I acyl-CoA hydrolase activity - - - - - - - - - - - - 4HBT_3 MMS1_k127_1017070_4 1223545.GS4_33_00590 7.456e-43 166.0 2CCI4@1|root,30BPJ@2|Bacteria,2IPV6@201174|Actinobacteria,4GGI5@85026|Gordoniaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1017070_0 1869.MB27_35085 5.287e-99 340.0 COG4320@1|root,COG4320@2|Bacteria,2GKEK@201174|Actinobacteria,4D9H0@85008|Micromonosporales 201174|Actinobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2252 MMS1_k127_1017070_6 159749.K0R6J4 0.0009174 44.0 COG0790@1|root,KOG1550@2759|Eukaryota,2XET5@2836|Bacillariophyta 2836|Bacillariophyta MOT Sel1-like repeats. - - - ko:K14026 ko04141,map04141 M00403 - - ko00000,ko00001,ko00002 - - - - MMS1_k127_1017070_5 436229.JOEH01000008_gene4081 2.247e-13 80.0 COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria,2NGB9@228398|Streptacidiphilus 201174|Actinobacteria S PFAM Archaeal ATPase - - - ko:K06921 - - - - ko00000 - - - ATPase_2,DUF234,HTH_5 MMS1_k127_1017070_3 351607.Acel_1987 5.717e-50 190.0 COG3336@1|root,COG3336@2|Bacteria,2IKZR@201174|Actinobacteria,4EX8B@85013|Frankiales 201174|Actinobacteria S Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - ko:K02351,ko:K07245 - - - - ko00000,ko02000 9.B.62.1 - - Caa3_CtaG MMS1_k127_1017070_1 656024.FsymDg_3556 8.728e-79 270.0 COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4EW0V@85013|Frankiales 201174|Actinobacteria IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 MMS1_k127_1039900_5 1122182.KB903813_gene2056 1.05e-44 168.0 COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria,4D9KN@85008|Micromonosporales 201174|Actinobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI MMS1_k127_1039900_6 1172180.KB911790_gene1362 7.393e-29 121.0 COG1846@1|root,COG1846@2|Bacteria,2IPBX@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator, marr family - - - - - - - - - - - - MarR,MarR_2 MMS1_k127_1039900_0 58123.JOFJ01000001_gene3028 2.482e-314 994.0 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4EHRZ@85012|Streptosporangiales 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 MMS1_k127_1039900_8 1121271.AUCM01000006_gene178 3.634e-16 91.0 COG0454@1|root,COG0456@2|Bacteria,1QUS0@1224|Proteobacteria,2TXDS@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_1039900_4 1173028.ANKO01000160_gene5070 7.664e-51 194.0 COG0637@1|root,COG0637@2|Bacteria,1G6EG@1117|Cyanobacteria,1HD99@1150|Oscillatoriales 1117|Cyanobacteria S TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - 3.1.3.23 ko:K19270 - - - - ko00000,ko01000 - - - HAD_2 MMS1_k127_1039900_10 219305.MCAG_03440 3.83e-07 61.0 COG3153@1|root,COG3153@2|Bacteria,2IBIF@201174|Actinobacteria 201174|Actinobacteria S Acetyltransferase (GNAT) family - - - - - - - - - - - - - MMS1_k127_1039900_3 1463881.KL591003_gene5793 6.622e-64 222.0 COG0386@1|root,COG0386@2|Bacteria,2IFJH@201174|Actinobacteria 201174|Actinobacteria O Belongs to the glutathione peroxidase family btuE - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx MMS1_k127_1039900_2 1283299.AUKG01000001_gene1479 3.335e-70 248.0 COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4CRRX@84995|Rubrobacteria 84995|Rubrobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 MMS1_k127_1039900_1 649831.L083_5783 2.541e-150 486.0 COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DA3S@85008|Micromonosporales 201174|Actinobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N MMS1_k127_1039900_7 479433.Caci_1553 1.201e-16 79.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family prr1 - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1054075_0 944560.HMPREF9058_2545 1.237e-160 514.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4D427@85005|Actinomycetales 201174|Actinobacteria E Cys/Met metabolism PLP-dependent enzyme aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 MMS1_k127_1054075_1 1121877.JQKF01000020_gene2504 3.134e-112 382.0 COG0641@1|root,COG0641@2|Bacteria,2GMTV@201174|Actinobacteria 201174|Actinobacteria V Radical SAM - - - ko:K06871 - - - - ko00000 - - - Radical_SAM,SEC-C,SPASM MMS1_k127_1073854_29 1122622.ATWJ01000014_gene394 4.725e-32 135.0 2AYN7@1|root,31QSQ@2|Bacteria,2IQ18@201174|Actinobacteria,4FJ6C@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1073854_25 1043493.BBLU01000005_gene2066 7.052e-42 160.0 2CJ2T@1|root,32S93@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1073854_13 526225.Gobs_2978 1.698e-86 299.0 COG4974@1|root,COG4974@2|Bacteria,2I6VQ@201174|Actinobacteria,4EXH7@85013|Frankiales 201174|Actinobacteria L Phage integrase family - - - ko:K14059 - - - - ko00000 - - - Phage_int_SAM_3,Phage_integrase MMS1_k127_1073854_37 253839.SSNG_01385 3.157e-13 78.0 COG0847@1|root,COG0847@2|Bacteria,2GP2K@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase III dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T MMS1_k127_1073854_28 345341.KUTG_07469 3.282e-32 137.0 COG2755@1|root,COG2755@2|Bacteria,2HPGH@201174|Actinobacteria,4E2HJ@85010|Pseudonocardiales 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 MMS1_k127_1073854_32 706191.PANA_0650 1.041e-27 119.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,1RSEU@1236|Gammaproteobacteria,3VY8P@53335|Pantoea 1236|Gammaproteobacteria G Belongs to the phosphoglycerate mutase family. GpmB subfamily gpmB - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5997 His_Phos_1 MMS1_k127_1073854_31 1123023.JIAI01000021_gene2390 8.748e-28 127.0 COG1835@1|root,COG1835@2|Bacteria,2IFE5@201174|Actinobacteria,4E36Z@85010|Pseudonocardiales 201174|Actinobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 MMS1_k127_1073854_6 1121372.AULK01000001_gene2016 2.076e-104 356.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FRES@85023|Microbacteriaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain fadD7 - - ko:K16029 ko01051,ko01052,map01051,map01052 - - - ko00000,ko00001 - - - AMP-binding,AMP-binding_C,PP-binding MMS1_k127_1073854_21 1048834.TC41_2724 1.198e-51 190.0 COG3565@1|root,COG3565@2|Bacteria,1V6AX@1239|Firmicutes,4HIET@91061|Bacilli 91061|Bacilli S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K06991 - - - - ko00000 - - - Glyoxalase MMS1_k127_1073854_12 66874.JOFS01000039_gene6852 4.162e-90 307.0 COG1809@1|root,COG1809@2|Bacteria,2IESE@201174|Actinobacteria 201174|Actinobacteria S PFAM (2R)-phospho-3-sulfolactate synthase ComA - - 4.4.1.19 ko:K08097 ko00680,ko01120,map00680,map01120 M00358 R07476 RC01799 ko00000,ko00001,ko00002,ko01000 - - - ComA MMS1_k127_1073854_35 298654.FraEuI1c_5090 2.613e-15 80.0 2C859@1|root,33MA2@2|Bacteria,2GSDZ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1073854_27 479433.Caci_0117 1.804e-34 145.0 COG2755@1|root,COG2755@2|Bacteria,2IC8X@201174|Actinobacteria 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 MMS1_k127_1073854_15 1386089.N865_10115 5.37e-80 274.0 COG1028@1|root,COG1028@2|Bacteria,2GKW9@201174|Actinobacteria,4FIQI@85021|Intrasporangiaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 MMS1_k127_1073854_1 1121877.JQKF01000037_gene1807 2.745e-145 493.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia 84992|Acidimicrobiia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS MMS1_k127_1073854_3 525909.Afer_0308 1.362e-134 441.0 COG1914@1|root,COG1914@2|Bacteria,2HGJ6@201174|Actinobacteria 201174|Actinobacteria P Metal ion transporter, metal ion (Mn2 Fe2 ) transporter (Nramp) family - - - - - - - - - - - - Nramp MMS1_k127_1073854_26 345341.KUTG_07469 1.075e-39 160.0 COG2755@1|root,COG2755@2|Bacteria,2HPGH@201174|Actinobacteria,4E2HJ@85010|Pseudonocardiales 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 MMS1_k127_1073854_41 1312959.KI914672_gene3438 0.000276 53.0 COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Big_5,Inhibitor_I9,PD40,Peptidase_S8,fn3 MMS1_k127_1073854_33 479432.Sros_5104 2.892e-23 114.0 COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4EPVC@85012|Streptosporangiales 201174|Actinobacteria M Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Big_3_5,Cytochrom_D1,Lactonase MMS1_k127_1073854_38 1160137.KB907307_gene1279 1.644e-11 67.0 2ASXR@1|root,31IDA@2|Bacteria,2GWS7@201174|Actinobacteria,4G579@85025|Nocardiaceae 201174|Actinobacteria S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N MMS1_k127_1073854_36 318424.EU78_11700 1.243e-13 75.0 2EJYH@1|root,33DP4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1073854_18 1206733.BAGC01000114_gene7148 1.67e-56 203.0 COG0640@1|root,COG0640@2|Bacteria,2IIA5@201174|Actinobacteria,4G1J7@85025|Nocardiaceae 201174|Actinobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_20 MMS1_k127_1073854_9 479432.Sros_5617 2.364e-96 326.0 COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4EFY4@85012|Streptosporangiales 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1073854_30 105425.BBPL01000008_gene1607 2.438e-31 133.0 COG1277@1|root,COG1277@2|Bacteria,2GJ2R@201174|Actinobacteria,2NI70@228398|Streptacidiphilus 201174|Actinobacteria S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4 MMS1_k127_1073854_22 1121924.ATWH01000011_gene375 7.649e-51 190.0 COG5340@1|root,COG5340@2|Bacteria,2INIK@201174|Actinobacteria,4FQT9@85023|Microbacteriaceae 201174|Actinobacteria K Psort location Cytoplasmic, score - - - - - - - - - - - - - MMS1_k127_1073854_19 1451261.AS96_02055 4.859e-56 208.0 COG2253@1|root,COG2253@2|Bacteria,2IHEW@201174|Actinobacteria,4FQ7K@85023|Microbacteriaceae 201174|Actinobacteria S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii MMS1_k127_1073854_20 1283283.ATXA01000001_gene511 4.265e-53 193.0 COG1309@1|root,COG1309@2|Bacteria,2IMN4@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N MMS1_k127_1073854_2 1283283.ATXA01000001_gene512 3.064e-140 461.0 COG0477@1|root,COG0477@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_1073854_16 1313172.YM304_19290 2.197e-76 272.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CNR5@84992|Acidimicrobiia 84992|Acidimicrobiia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH MMS1_k127_1073854_24 1121877.JQKF01000004_gene1089 1.677e-45 175.0 COG2120@1|root,COG2120@2|Bacteria,2HF8J@201174|Actinobacteria,4CNQ6@84992|Acidimicrobiia 84992|Acidimicrobiia S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L MMS1_k127_1073854_23 1313172.YM304_26950 3.704e-46 171.0 COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CN4B@84992|Acidimicrobiia 84992|Acidimicrobiia K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone MMS1_k127_1073854_39 648885.KB316282_gene561 5.092e-05 53.0 COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2TSTG@28211|Alphaproteobacteria,1JQPG@119045|Methylobacteriaceae 28211|Alphaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA MMS1_k127_1073854_34 1003195.SCAT_5518 1.129e-22 114.0 COG1846@1|root,COG1846@2|Bacteria,2IH3H@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - MarR,MarR_2 MMS1_k127_1073854_0 326424.FRAAL3996 2.337e-233 735.0 COG0477@1|root,COG0477@2|Bacteria,2GJSC@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_1073854_14 351607.Acel_1086 5.53e-83 288.0 COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4ESPS@85013|Frankiales 201174|Actinobacteria E High-affinity branched-chain amino acid transport protein (ABC superfamily - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS1_k127_1073854_7 1123322.KB904653_gene826 2.101e-97 325.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria 201174|Actinobacteria E ABC transporter livG - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS1_k127_1073854_4 351607.Acel_1084 1.81e-119 398.0 COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4ERGG@85013|Frankiales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1073854_5 351607.Acel_1083 5.277e-109 361.0 COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4ESA3@85013|Frankiales 201174|Actinobacteria E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1073854_8 351607.Acel_1082 4.613e-97 331.0 COG0683@1|root,COG0683@2|Bacteria,2GM00@201174|Actinobacteria,4ESCY@85013|Frankiales 201174|Actinobacteria E PFAM Extracellular ligand-binding receptor braC - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS1_k127_1073854_17 1313172.YM304_26970 2.009e-57 212.0 COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4CN5D@84992|Acidimicrobiia 84992|Acidimicrobiia K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 MMS1_k127_1073854_10 1229780.BN381_80328 1.233e-91 312.0 COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,3UWHI@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Peptidase family M28 - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 MMS1_k127_1073854_11 1120950.KB892784_gene202 6.705e-91 302.0 COG2171@1|root,COG2171@2|Bacteria,2IBDI@201174|Actinobacteria 201174|Actinobacteria E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 MMS1_k127_1095454_11 1120948.KB903217_gene852 2.891e-50 183.0 COG1177@1|root,COG1177@2|Bacteria,2GM0E@201174|Actinobacteria,4DZ18@85010|Pseudonocardiales 201174|Actinobacteria E Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 MMS1_k127_1095454_5 1172181.KB911709_gene6923 3.071e-125 411.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria 201174|Actinobacteria E Belongs to the ABC transporter superfamily - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 MMS1_k127_1095454_7 497321.C664_15713 8.527e-105 367.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,dCache_1 MMS1_k127_1095454_2 208444.JNYY01000018_gene306 2.151e-189 606.0 COG0531@1|root,COG0531@2|Bacteria,2GIWQ@201174|Actinobacteria,4DYNN@85010|Pseudonocardiales 201174|Actinobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 MMS1_k127_1095454_1 1449346.JQMO01000003_gene2909 2.841e-194 616.0 COG0174@1|root,COG0174@2|Bacteria,2GM3K@201174|Actinobacteria,2M1ZH@2063|Kitasatospora 201174|Actinobacteria E Glutamine synthetase, catalytic domain glnA4 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C MMS1_k127_1095454_0 710696.Intca_2350 2.105e-205 652.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FFHF@85021|Intrasporangiaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family aldC - 1.2.1.3,1.2.1.39,1.2.1.8 ko:K00128,ko:K00130,ko:K00146 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1095454_6 1172188.KB911821_gene1479 9.607e-121 392.0 COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4FEEM@85021|Intrasporangiaceae 201174|Actinobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 MMS1_k127_1095454_4 1163407.UU7_13373 1.775e-126 411.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1SMCF@1236|Gammaproteobacteria,1X5QG@135614|Xanthomonadales 135614|Xanthomonadales E Pyridoxal-5-phosphate-dependent protein subunit beta - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS1_k127_1095454_13 1121877.JQKF01000016_gene162 4.685e-37 152.0 COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia 84992|Acidimicrobiia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 MMS1_k127_1095454_8 1313172.YM304_09730 1.951e-100 338.0 COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2GJUZ@201174|Actinobacteria,4CMV4@84992|Acidimicrobiia 84992|Acidimicrobiia F Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA MMS1_k127_1095454_12 543632.JOJL01000017_gene9966 2.251e-49 186.0 COG4221@1|root,COG4221@2|Bacteria,2GN3I@201174|Actinobacteria,4DMF3@85008|Micromonosporales 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short MMS1_k127_1095454_3 1035308.AQYY01000001_gene3341 8.005e-131 428.0 COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,26088@186807|Peptococcaceae 186801|Clostridia F Deoxyguanosinetriphosphate triphosphohydrolase dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc MMS1_k127_1095454_14 525909.Afer_0348 1.071e-16 84.0 2E3M2@1|root,31DE4@2|Bacteria,2HH0X@201174|Actinobacteria,4CP16@84992|Acidimicrobiia 84992|Acidimicrobiia S Protein of unknown function (DUF3107) - - - - - - - - - - - - DUF3107 MMS1_k127_1095454_10 525909.Afer_0351 1.709e-89 307.0 COG1387@1|root,COG1387@2|Bacteria,2IR14@201174|Actinobacteria,4CNF5@84992|Acidimicrobiia 84992|Acidimicrobiia E Histidinol phosphate phosphatase, HisJ - - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - - MMS1_k127_1095454_9 1150599.MPHLEI_02083 7.299e-95 329.0 COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,235I0@1762|Mycobacteriaceae 201174|Actinobacteria T Histidine kinase pdtaS GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 ko:K00936 - M00839 - - ko00000,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,H_kinase_N,HisKA_2,PAS_4 MMS1_k127_113814_16 1313172.YM304_10640 4.461e-97 320.0 COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CMTI@84992|Acidimicrobiia 84992|Acidimicrobiia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N MMS1_k127_113814_27 979556.MTES_0414 1.068e-13 82.0 COG0712@1|root,COG0712@2|Bacteria,2GMJ5@201174|Actinobacteria,4FN91@85023|Microbacteriaceae 201174|Actinobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02109,ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,OSCP MMS1_k127_113814_26 1122609.AUGT01000021_gene1242 3.399e-20 97.0 COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria 201174|Actinobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B MMS1_k127_113814_25 351607.Acel_0648 1.512e-23 103.0 COG0636@1|root,COG0636@2|Bacteria,2IQZQ@201174|Actinobacteria,4EWJ5@85013|Frankiales 201174|Actinobacteria C ATP synthase subunit C atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0015988,GO:0015991,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iNJ661.Rv1305 ATP-synt_C MMS1_k127_113814_20 1048339.KB913029_gene3391 4.549e-59 213.0 COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4ETD3@85013|Frankiales 201174|Actinobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A MMS1_k127_113814_28 562970.Btus_3241 1.893e-05 50.0 COG5336@1|root,COG5336@2|Bacteria,1VF5M@1239|Firmicutes,4I9VP@91061|Bacilli,278Q1@186823|Alicyclobacillaceae 91061|Bacilli S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 MMS1_k127_113814_14 525909.Afer_1804 2.076e-108 362.0 COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4CMRB@84992|Acidimicrobiia 84992|Acidimicrobiia M Glycosyl transferase family 4 wecA - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 MMS1_k127_113814_6 1229780.BN381_10027 1.277e-176 562.0 COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,3UWBD@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT MMS1_k127_113814_21 1229780.BN381_10026 5.018e-46 175.0 COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,3UWPM@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB MMS1_k127_113814_5 66373.JOFQ01000002_gene4838 8.066e-180 579.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria 201174|Actinobacteria I Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta accD2 - - - - - - - - - - - Carboxyl_trans MMS1_k127_113814_2 1211815.CBYP010000063_gene1912 1.735e-250 795.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 MMS1_k127_113814_1 1211815.CBYP010000063_gene1911 1.306e-250 785.0 COG3185@1|root,COG3185@2|Bacteria,2GJNC@201174|Actinobacteria,4EU7X@85013|Frankiales 201174|Actinobacteria E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA MMS1_k127_113814_18 1229780.BN381_50072 8.593e-68 253.0 28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria,3UXBU@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S DinB superfamily - - - - - - - - - - - - MDMPI_N,Wyosine_form MMS1_k127_113814_17 298654.FraEuI1c_2880 6.586e-69 243.0 COG1024@1|root,COG1024@2|Bacteria,2GJ0N@201174|Actinobacteria,4ESJA@85013|Frankiales 201174|Actinobacteria I Enoyl-CoA hydratase - - 4.2.1.17,4.2.1.18 ko:K01692,ko:K13766 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00036,M00087 R02085,R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 MMS1_k127_113814_24 390989.JOEG01000014_gene3180 2.568e-28 124.0 COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4D9KF@85008|Micromonosporales 201174|Actinobacteria J Belongs to the SUA5 family ywlC GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC MMS1_k127_113814_22 1229780.BN381_10021 3.351e-42 166.0 COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,3UWRW@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 MMS1_k127_113814_12 1121877.JQKF01000003_gene1533 2.326e-125 410.0 COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CMPQ@84992|Acidimicrobiia 84992|Acidimicrobiia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 MMS1_k127_113814_23 525909.Afer_1810 6.324e-31 123.0 COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria,4CP0K@84992|Acidimicrobiia 84992|Acidimicrobiia J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 MMS1_k127_113814_4 1121877.JQKF01000003_gene1536 4.265e-186 598.0 COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CMS7@84992|Acidimicrobiia 84992|Acidimicrobiia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_RNA_bind MMS1_k127_113814_11 1173024.KI912148_gene3509 2.008e-133 433.0 COG0498@1|root,COG0498@2|Bacteria,1G31E@1117|Cyanobacteria,1JHGQ@1189|Stigonemataceae 1117|Cyanobacteria E Pyridoxal-phosphate dependent enzyme thrC GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS1_k127_113814_13 1229780.BN381_10012 4.333e-117 390.0 COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,3UWE2@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Homoserine dehydrogenase hom GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1294 ACT,Homoserine_dh,NAD_binding_3 MMS1_k127_113814_9 391625.PPSIR1_06983 3.034e-141 460.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC MMS1_k127_113814_19 298655.KI912266_gene6054 1.127e-61 221.0 COG0500@1|root,COG2226@2|Bacteria,2GNVG@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 MMS1_k127_113814_7 446466.Cfla_3227 1.957e-161 531.0 COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4F323@85016|Cellulomonadaceae 201174|Actinobacteria J elongation factor Tu domain 2 protein fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 MMS1_k127_113814_8 478801.Ksed_22920 7.529e-149 480.0 COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria 201174|Actinobacteria L Transposase and inactivated derivatives IS30 family - - - - - - - - - - - - HTH_38,rve MMS1_k127_113814_15 1313172.YM304_20190 1.541e-103 355.0 COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4CMXD@84992|Acidimicrobiia 84992|Acidimicrobiia G Pyruvate kinase, barrel domain - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C MMS1_k127_113814_0 861299.J421_1491 1.509e-281 876.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1ZSZ7@142182|Gemmatimonadetes 142182|Gemmatimonadetes CE Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2,Pyr_redox_3 MMS1_k127_113814_3 379066.GAU_2381 8.863e-243 769.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1ZSVF@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N MMS1_k127_113814_10 379066.GAU_2382 7.386e-139 451.0 COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C MMS1_k127_115065_15 351607.Acel_1194 3.511e-52 197.0 COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4EUSY@85013|Frankiales 201174|Actinobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 MMS1_k127_115065_9 1283299.AUKG01000001_gene2342 1.393e-90 309.0 COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria 201174|Actinobacteria G polyphosphate kinase - - - - - - - - - - - - PPK2 MMS1_k127_115065_12 1449346.JQMO01000003_gene6573 7.952e-60 218.0 COG0657@1|root,COG0657@2|Bacteria,2GJYR@201174|Actinobacteria,2M46G@2063|Kitasatospora 201174|Actinobacteria I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 MMS1_k127_115065_19 653045.Strvi_2770 7.641e-21 98.0 COG4829@1|root,COG4829@2|Bacteria 2|Bacteria Q muconolactone delta-isomerase catC - 5.3.3.4 ko:K03464 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00568 R06990 RC01109 ko00000,ko00001,ko00002,ko01000 - - - MIase MMS1_k127_115065_6 1123023.JIAI01000001_gene6306 1.493e-96 327.0 COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4E0WV@85010|Pseudonocardiales 201174|Actinobacteria K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 MMS1_k127_115065_0 312284.A20C1_08358 1.641e-179 571.0 COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria 201174|Actinobacteria M mandelate racemase muconate lactonizing - - 5.5.1.27 ko:K18983 ko00053,map00053 - R10847 RC03287 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N MMS1_k127_115065_2 1128421.JAGA01000002_gene1481 5.608e-132 440.0 COG1129@1|root,COG1129@2|Bacteria,2NPR8@2323|unclassified Bacteria 2|Bacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system rbsA - 3.6.3.17 ko:K10441,ko:K10562 ko02010,map02010 M00212,M00220 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9 - - ABC_tran MMS1_k127_115065_14 298654.FraEuI1c_3907 1.865e-52 200.0 COG1172@1|root,COG1172@2|Bacteria,2GM6S@201174|Actinobacteria 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family rhaP - - ko:K10560 ko02010,map02010 M00220 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 - - BPD_transp_2 MMS1_k127_115065_13 1382306.JNIM01000001_gene25 3.661e-54 203.0 COG1172@1|root,COG1172@2|Bacteria,2G6DF@200795|Chloroflexi 200795|Chloroflexi G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10561 ko02010,map02010 M00220 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.9 - - BPD_transp_2 MMS1_k127_115065_16 1386089.N865_14075 5.075e-44 174.0 COG1879@1|root,COG1879@2|Bacteria,2I43Z@201174|Actinobacteria 201174|Actinobacteria G ABC transporter rhaS - - ko:K02058,ko:K10559 ko02010,map02010 M00220,M00221 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.9 - - Peripla_BP_4 MMS1_k127_115065_5 469383.Cwoe_1022 7.573e-110 369.0 COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria,4CT8G@84995|Rubrobacteria 84995|Rubrobacteria M PFAM Mandelate racemase muconate lactonizing - - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N MMS1_k127_115065_17 469383.Cwoe_1027 3.707e-32 134.0 COG3254@1|root,COG3254@2|Bacteria,2IQ69@201174|Actinobacteria,4CQVY@84995|Rubrobacteria 84995|Rubrobacteria S L-rhamnose mutarotase - - 5.1.3.32 ko:K03534 - - R10819 RC00563 ko00000,ko01000 - - - rhaM MMS1_k127_115065_1 469383.Cwoe_1026 3.58e-135 440.0 COG0673@1|root,COG0673@2|Bacteria,2IMUZ@201174|Actinobacteria 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA MMS1_k127_115065_20 1120948.KB903248_gene4342 4.773e-14 76.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4E04X@85010|Pseudonocardiales 201174|Actinobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex sucB GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008289,GO:0009405,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0030312,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043177,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS1_k127_115065_8 469383.Cwoe_1943 1.233e-91 318.0 COG1071@1|root,COG1071@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor - - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh MMS1_k127_115065_10 1172188.KB911828_gene4081 1.654e-84 291.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4FIX9@85021|Intrasporangiaceae 201174|Actinobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C MMS1_k127_115065_7 469383.Cwoe_1030 3.955e-95 320.0 COG3618@1|root,COG3618@2|Bacteria,2GM2D@201174|Actinobacteria,4CTQP@84995|Rubrobacteria 84995|Rubrobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 MMS1_k127_115065_11 1123023.JIAI01000001_gene6307 1.59e-81 279.0 COG1028@1|root,COG1028@2|Bacteria,2H2ZB@201174|Actinobacteria 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 MMS1_k127_115065_3 864563.HMPREF9166_0055 1.308e-119 394.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,4H2UP@909932|Negativicutes 909932|Negativicutes CE Dehydrogenase icd - 1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73 ko:K00030,ko:K07246 ko00020,ko00630,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00650,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00215,R00709,R01751,R02545,R06180 RC00084,RC00105,RC00114,RC00594 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh MMS1_k127_115065_4 1229203.KI301992_gene2444 2.272e-113 381.0 COG0318@1|root,COG0318@2|Bacteria,2I916@201174|Actinobacteria,3UX40@52018|unclassified Actinobacteria (class) 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C MMS1_k127_115065_18 1304865.JAGF01000001_gene3516 5.409e-23 101.0 COG1433@1|root,COG1433@2|Bacteria,2GSU0@201174|Actinobacteria 201174|Actinobacteria S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - Nitro_FeMo-Co MMS1_k127_1254225_31 1121877.JQKF01000036_gene1791 1.037e-30 137.0 COG2385@1|root,COG2385@2|Bacteria,2HGNA@201174|Actinobacteria,4CNPA@84992|Acidimicrobiia 84992|Acidimicrobiia D sporulation resulting in formation of a cellular spore - - - - - - - - - - - - - MMS1_k127_1254225_32 479433.Caci_5057 4.476e-29 125.0 COG0668@1|root,COG0668@2|Bacteria,2IQWA@201174|Actinobacteria 201174|Actinobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel MMS1_k127_1254225_35 66874.JOFS01000006_gene4436 4.286e-18 97.0 COG5542@1|root,COG5542@2|Bacteria,2GJQF@201174|Actinobacteria 201174|Actinobacteria NT integral membrane protein - - - - - - - - - - - - Mannosyl_trans2,PMT_2 MMS1_k127_1254225_34 1536769.P40081_01670 1.728e-27 125.0 COG0346@1|root,COG0346@2|Bacteria,1VP7J@1239|Firmicutes,4HVYV@91061|Bacilli,26XIC@186822|Paenibacillaceae 91061|Bacilli E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase,Glyoxalase_2 MMS1_k127_1254225_11 1077972.ARGLB_073_01170 6.086e-92 313.0 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria,1WBDM@1268|Micrococcaceae 201174|Actinobacteria Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 MMS1_k127_1254225_13 525909.Afer_0507 6.986e-83 285.0 COG0559@1|root,COG0559@2|Bacteria,2GMAY@201174|Actinobacteria,4CN5E@84992|Acidimicrobiia 84992|Acidimicrobiia U Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1254225_20 525909.Afer_0506 1.487e-73 260.0 COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4CN85@84992|Acidimicrobiia 84992|Acidimicrobiia U Branched-chain amino acid transport system / permease component - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1254225_14 1121877.JQKF01000020_gene2500 9.237e-82 281.0 COG0411@1|root,COG0411@2|Bacteria,2I3Z1@201174|Actinobacteria,4CP54@84992|Acidimicrobiia 84992|Acidimicrobiia E ATPases associated with a variety of cellular activities - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS1_k127_1254225_25 1121877.JQKF01000020_gene2501 1.664e-67 237.0 COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4CN2Y@84992|Acidimicrobiia 84992|Acidimicrobiia E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS1_k127_1254225_12 1121877.JQKF01000020_gene2502 9.988e-91 314.0 COG0683@1|root,COG0683@2|Bacteria,2HGK2@201174|Actinobacteria,4CNIP@84992|Acidimicrobiia 84992|Acidimicrobiia E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS1_k127_1254225_4 101510.RHA1_ro06954 6.047e-143 465.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4G0B5@85025|Nocardiaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 MMS1_k127_1254225_2 928724.SacglDRAFT_02396 1.328e-152 495.0 COG0119@1|root,COG0119@2|Bacteria,2IEH9@201174|Actinobacteria 201174|Actinobacteria E HMGL-like - - - - - - - - - - - - HMGL-like MMS1_k127_1254225_29 1205910.B005_0237 3.354e-43 168.0 COG1414@1|root,COG1414@2|Bacteria,2IK1Y@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - ko:K02624,ko:K13641 - - - - ko00000,ko03000 - - - HTH_IclR,IclR MMS1_k127_1254225_0 1122239.AULS01000002_gene911 1.455e-206 657.0 COG2079@1|root,COG2079@2|Bacteria,2GKUR@201174|Actinobacteria,4FMAS@85023|Microbacteriaceae 201174|Actinobacteria S MmgE/PrpD family prpD GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD MMS1_k127_1254225_8 67352.JODS01000009_gene7486 1.175e-117 386.0 COG2513@1|root,COG2513@2|Bacteria,2GJZZ@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase MMS1_k127_1254225_17 298653.Franean1_5685 3.477e-79 276.0 COG4638@1|root,COG4638@2|Bacteria,2GQNV@201174|Actinobacteria,4EV83@85013|Frankiales 201174|Actinobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske MMS1_k127_1254225_22 1266908.AQPB01000059_gene2665 1.056e-70 258.0 COG0642@1|root,COG2206@1|root,COG2205@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T domain protein - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_4,PAS_9 MMS1_k127_1254225_26 208444.JNYY01000003_gene1962 4.081e-67 233.0 COG2318@1|root,COG2318@2|Bacteria,2HUJD@201174|Actinobacteria,4E3F8@85010|Pseudonocardiales 201174|Actinobacteria S Protein of unknown function (DUF664) - - - - - - - - - - - - DUF664 MMS1_k127_1254225_9 349163.Acry_2355 4.356e-98 327.0 COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,2JQYQ@204441|Rhodospirillales 204441|Rhodospirillales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 MMS1_k127_1254225_16 479431.Namu_3914 3.091e-80 292.0 COG4177@1|root,COG4177@2|Bacteria,2GNZK@201174|Actinobacteria 201174|Actinobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1254225_15 935839.JAGJ01000010_gene306 7.696e-81 285.0 COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4F5DK@85017|Promicromonosporaceae 201174|Actinobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1254225_19 1504319.GM45_1595 6.127e-77 264.0 COG0410@1|root,COG0410@2|Bacteria,2I93D@201174|Actinobacteria,3UX8R@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS1_k127_1254225_18 1045009.AFXQ01000011_gene445 2.108e-78 269.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,1W9SW@1268|Micrococcaceae 201174|Actinobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS1_k127_1254225_10 105425.BBPL01000014_gene2768 1.505e-95 327.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component MA20_23475 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS1_k127_1254225_5 1464048.JNZS01000008_gene6199 2.263e-141 460.0 COG1680@1|root,COG1680@2|Bacteria,2H2SY@201174|Actinobacteria,4D941@85008|Micromonosporales 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase MMS1_k127_1254225_21 469371.Tbis_0412 7.242e-71 250.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator MA20_14935 - - - - - - - - - - - TetR_N MMS1_k127_1254225_3 1122939.ATUD01000019_gene1562 2.598e-147 484.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C MMS1_k127_1254225_1 1121946.AUAX01000026_gene6325 1.668e-183 594.0 COG0365@1|root,COG0365@2|Bacteria,2GM20@201174|Actinobacteria,4D8NB@85008|Micromonosporales 201174|Actinobacteria I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C MMS1_k127_1254225_24 1121926.AXWO01000030_gene4211 5.351e-70 248.0 COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4EXKF@85014|Glycomycetales 201174|Actinobacteria I Putative undecaprenyl diphosphate synthase uppS2 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 - R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf MMS1_k127_1254225_33 269800.Tfu_0872 4.056e-28 117.0 COG0640@1|root,COG0640@2|Bacteria,2IKK2@201174|Actinobacteria,4EJRU@85012|Streptosporangiales 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 MMS1_k127_1254225_27 525368.HMPREF0591_2519 3.474e-52 190.0 COG3260@1|root,COG3260@2|Bacteria,2IDTD@201174|Actinobacteria,238TU@1762|Mycobacteriaceae 201174|Actinobacteria C oxidoreductase hycG - - - - - - - - - - - Oxidored_q6 MMS1_k127_1254225_7 419947.MRA_0087 1.101e-123 420.0 COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,2352A@1762|Mycobacteriaceae 201174|Actinobacteria CP Proton-conducting membrane transporter - - - ko:K12137 - - - - ko00000,ko01000 - - - Proton_antipo_M MMS1_k127_1254225_23 1116232.AHBF01000154_gene4055 1.646e-70 254.0 COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria 201174|Actinobacteria C Formate hydrogenlyase hycD - - ko:K12138 - - - - ko00000,ko01000 - - - NADHdh MMS1_k127_1254225_28 1394178.AWOO02000002_gene1779 3.231e-44 172.0 COG4237@1|root,COG4237@2|Bacteria,2HQ3P@201174|Actinobacteria 201174|Actinobacteria C Hydrogenase 4 membrane hycP GO:0008150,GO:0040007 - ko:K12140 - - - - ko00000,ko01000 - - - - MMS1_k127_1254225_6 1304865.JAGF01000001_gene3524 1.245e-128 426.0 COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria 201174|Actinobacteria CP Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit hycQ - - ko:K12141 - - - - ko00000,ko01000 - - - Proton_antipo_M MMS1_k127_1254225_30 216594.MMAR_1659 7.146e-31 127.0 COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2GYM5@201174|Actinobacteria,236WB@1762|Mycobacteriaceae 201174|Actinobacteria C Respiratory-chain NADH dehydrogenase, 30 Kd subunit hycE - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases MMS1_k127_1268737_2 68570.DC74_2935 7.392e-21 95.0 2AV32@1|root,31KT0@2|Bacteria,2IM6S@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1268737_0 864563.HMPREF9166_1276 4.683e-58 216.0 COG3723@1|root,COG3723@2|Bacteria,1UNDF@1239|Firmicutes,4H38J@909932|Negativicutes 909932|Negativicutes L Recombinase, phage RecT family recT - - ko:K07455 - - - - ko00000,ko03400 - - - RecT MMS1_k127_1268737_1 1121335.Clst_0374 2.622e-45 177.0 COG5377@1|root,COG5377@2|Bacteria,1TS2Y@1239|Firmicutes,249SB@186801|Clostridia,3WKYR@541000|Ruminococcaceae 186801|Clostridia L YqaJ viral recombinase family - - - - - - - - - - - - YqaJ MMS1_k127_1268737_4 1088869.GMO_11240 2.424e-05 55.0 2CHZY@1|root,32YTS@2|Bacteria,1P5HR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - MMS1_k127_1268737_3 1440774.Y900_014790 6.125e-14 79.0 COG4420@1|root,COG4420@2|Bacteria,2IHZA@201174|Actinobacteria 201174|Actinobacteria S membrane - - - - - - - - - - - - - MMS1_k127_1324353_32 1136417.AZWE01000058_gene293 2.592e-55 197.0 COG3945@1|root,COG3945@2|Bacteria,2I92G@201174|Actinobacteria,4DDTU@85008|Micromonosporales 201174|Actinobacteria S Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red MMS1_k127_1324353_40 101510.RHA1_ro11322 1.14e-07 60.0 29421@1|root,2ZRGT@2|Bacteria,2INS4@201174|Actinobacteria,4FZJ5@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1324353_10 697303.Thewi_2496 1.447e-126 423.0 COG0249@1|root,COG0249@2|Bacteria,1UYBJ@1239|Firmicutes,249T9@186801|Clostridia,42HQ4@68295|Thermoanaerobacterales 186801|Clostridia L SMART DNA mismatch repair protein MutS, C-terminal - - - - - - - - - - - - MutS_V MMS1_k127_1324353_11 1499967.BAYZ01000154_gene1467 2.762e-124 417.0 COG0249@1|root,COG0249@2|Bacteria 2|Bacteria L mismatched DNA binding mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_III,MutS_V MMS1_k127_1324353_42 1122223.KB890696_gene438 3.341e-05 57.0 COG0582@1|root,COG0582@2|Bacteria 2|Bacteria L DNA integration - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase MMS1_k127_1324353_31 543632.JOJL01000002_gene8239 4.249e-57 220.0 COG2508@1|root,COG2508@2|Bacteria,2I8HD@201174|Actinobacteria 201174|Actinobacteria QT transcriptional regulator, PucR family - - - - - - - - - - - - HTH_30 MMS1_k127_1324353_5 414996.IL38_17980 4.04e-151 494.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,408KZ@622450|Actinopolysporales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C MMS1_k127_1324353_20 526225.Gobs_3681 3.761e-85 298.0 COG3386@1|root,COG3386@2|Bacteria,2HE8D@201174|Actinobacteria,4ETTP@85013|Frankiales 201174|Actinobacteria G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.15 ko:K13874,ko:K14274 ko00040,ko00053,ko01100,map00040,map00053,map01100 - R02427,R02526 RC00537,RC00713 ko00000,ko00001,ko01000 - - - SGL MMS1_k127_1324353_25 1120949.KB903321_gene2703 5.384e-73 258.0 COG1172@1|root,COG1172@2|Bacteria,2GM6S@201174|Actinobacteria 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family - - - - - - - - - - - - BPD_transp_2 MMS1_k127_1324353_29 1120949.KB903321_gene2704 1.31e-60 222.0 COG1172@1|root,COG1172@2|Bacteria,2GJDW@201174|Actinobacteria,4DAPI@85008|Micromonosporales 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 MMS1_k127_1324353_7 1394178.AWOO02000006_gene3435 2.308e-142 471.0 COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria 201174|Actinobacteria G Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran MMS1_k127_1324353_26 1120949.KB903321_gene2706 4.941e-72 256.0 COG1879@1|root,COG1879@2|Bacteria 2|Bacteria G ABC-type sugar transport system periplasmic component - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 MMS1_k127_1324353_18 926560.KE387023_gene2049 1.233e-102 359.0 COG5001@1|root,COG5001@2|Bacteria,1WK20@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4 MMS1_k127_1324353_9 1035308.AQYY01000001_gene3228 1.295e-130 428.0 COG1150@1|root,COG1150@2|Bacteria,1V8UM@1239|Firmicutes,24J4U@186801|Clostridia,2622W@186807|Peptococcaceae 186801|Clostridia C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_17,Fer4_8 MMS1_k127_1324353_37 1035308.AQYY01000001_gene3229 3.314e-27 115.0 2B34W@1|root,31VSM@2|Bacteria,1W5MQ@1239|Firmicutes,256XB@186801|Clostridia,266PY@186807|Peptococcaceae 186801|Clostridia - - - - - - - - - - - - - - - MMS1_k127_1324353_2 1035308.AQYY01000001_gene3230 2.607e-213 679.0 COG1148@1|root,COG1148@2|Bacteria,1V5YJ@1239|Firmicutes,248CC@186801|Clostridia,260ZH@186807|Peptococcaceae 186801|Clostridia C binding domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 MMS1_k127_1324353_0 1035308.AQYY01000001_gene3231 0.0 1103.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Pyr_redox_2 MMS1_k127_1324353_28 1121422.AUMW01000009_gene3345 9.856e-61 215.0 COG2210@1|root,COG2210@2|Bacteria,1UIFM@1239|Firmicutes,24H1I@186801|Clostridia,261QA@186807|Peptococcaceae 186801|Clostridia S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 MMS1_k127_1324353_35 1035308.AQYY01000001_gene3233 3.141e-46 174.0 COG1908@1|root,COG1908@2|Bacteria,1V80C@1239|Firmicutes,24MB7@186801|Clostridia 186801|Clostridia C Methyl-viologen-reducing hydrogenase, delta subunit - - 1.8.98.5,1.8.98.6 ko:K14127 ko00680,map00680 - R00019,R11943,R11944 RC00011 ko00000,ko00001,ko01000 - - - FlpD MMS1_k127_1324353_36 1035308.AQYY01000001_gene3234 1.573e-31 126.0 COG0425@1|root,COG0425@2|Bacteria,1UWPI@1239|Firmicutes,25HWP@186801|Clostridia,265U8@186807|Peptococcaceae 186801|Clostridia O Sulfurtransferase TusA - - - - - - - - - - - - TusA MMS1_k127_1324353_38 751944.HALDL1_11545 6.296e-14 79.0 COG0824@1|root,arCOG01137@2157|Archaea,2XZ99@28890|Euryarchaeota,23WUB@183963|Halobacteria 183963|Halobacteria S Thioesterase superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 MMS1_k127_1324353_24 312284.A20C1_11136 1.062e-74 267.0 COG1063@1|root,COG1063@2|Bacteria,2GK3U@201174|Actinobacteria 201174|Actinobacteria E Dehydrogenase - - 1.4.1.11 ko:K18012 ko00310,map00310 - R03349 RC00888 ko00000,ko00001,ko01000 - - - - MMS1_k127_1324353_15 312284.A20C1_11146 1.568e-109 360.0 COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria 201174|Actinobacteria K beta-keto acid cleavage enzyme - - - - - - - - - - - - BKACE MMS1_k127_1324353_21 1123023.JIAI01000011_gene9009 7.533e-80 276.0 COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria 201174|Actinobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - ko:K07048 - - - - ko00000 - - - PTE MMS1_k127_1324353_19 2045.KR76_08295 4.348e-91 318.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4DNWU@85009|Propionibacteriales 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase MMS1_k127_1324353_12 330084.JNYZ01000005_gene931 4.294e-123 405.0 COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DXRP@85010|Pseudonocardiales 201174|Actinobacteria E Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS1_k127_1324353_13 330084.JNYZ01000005_gene930 7.001e-121 400.0 COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria 201174|Actinobacteria EP Belongs to the ABC transporter superfamily - - - - - - - - - - - - ABC_tran,oligo_HPY MMS1_k127_1324353_16 1416759.AYMR01000003_gene3371 1.896e-107 358.0 COG1173@1|root,COG1173@2|Bacteria,2GKAW@201174|Actinobacteria,4FMH9@85023|Microbacteriaceae 201174|Actinobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N MMS1_k127_1324353_17 1416759.AYMR01000003_gene3372 2.292e-107 357.0 COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4FR2U@85023|Microbacteriaceae 201174|Actinobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS1_k127_1324353_8 1122138.AQUZ01000024_gene7626 1.161e-131 438.0 COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,4DPH8@85009|Propionibacteriales 201174|Actinobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS1_k127_1324353_33 312284.A20C1_11151 1.837e-48 183.0 COG1309@1|root,COG1309@2|Bacteria,2IDMJ@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_4,TetR_N MMS1_k127_1324353_39 67373.JOBF01000006_gene2584 1.026e-12 77.0 COG1686@1|root,COG1686@2|Bacteria,2GM2X@201174|Actinobacteria 201174|Actinobacteria M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 MMS1_k127_1324353_41 996637.SGM_0011 3.135e-06 57.0 COG1686@1|root,COG1686@2|Bacteria,2GM2X@201174|Actinobacteria 201174|Actinobacteria M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 MMS1_k127_1324353_34 1120972.AUMH01000012_gene106 2.248e-48 184.0 COG1376@1|root,COG1376@2|Bacteria,1VVTU@1239|Firmicutes 1239|Firmicutes M L,D-transpeptidase catalytic domain - - - - - - - - - - - - PG_binding_1,YkuD MMS1_k127_1324353_27 298653.Franean1_5441 7.183e-64 237.0 COG2837@1|root,COG2837@2|Bacteria,2GMNJ@201174|Actinobacteria,4ES2T@85013|Frankiales 201174|Actinobacteria P TIGRFAM Dyp-type peroxidase family yfeX - - ko:K07223 - - - - ko00000 - - - Dyp_perox MMS1_k127_1324353_22 1101188.KI912156_gene4063 8.469e-78 273.0 2DBVK@1|root,2ZBBH@2|Bacteria,2H5Z5@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1324353_6 266117.Rxyl_3175 8.216e-150 488.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CPTR@84995|Rubrobacteria 84995|Rubrobacteria C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1324353_30 640081.Dsui_1104 1.252e-58 211.0 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,2VQZE@28216|Betaproteobacteria,2KW2S@206389|Rhodocyclales 206389|Rhodocyclales Q Thioesterase superfamily - - - - - - - - - - - - 4HBT MMS1_k127_1324353_1 448385.sce4570 8.745e-284 890.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2YW7G@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2101 PEP-utilizers,PEP-utilizers_C,PPDK_N MMS1_k127_1324353_14 1001240.GY21_18590 4.086e-113 374.0 COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,4FKY4@85023|Microbacteriaceae 201174|Actinobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C MMS1_k127_1324353_3 479432.Sros_1806 4.482e-161 519.0 COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4EHG3@85012|Streptosporangiales 201174|Actinobacteria CG UDP-glucoronosyl and UDP-glucosyl transferase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - - - - - - - - - - Glyco_tran_28_C,UDPGT MMS1_k127_1324353_23 1441629.PCH70_40260 1.551e-77 272.0 COG1633@1|root,COG1633@2|Bacteria,1QW2P@1224|Proteobacteria,1S4MR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Ferritin-like - - - - - - - - - - - - Ferritin-like,SnoaL_2 MMS1_k127_1324353_4 1121877.JQKF01000029_gene2097 8.322e-154 511.0 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE9 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_1389174_0 1121877.JQKF01000037_gene1807 9.946e-138 464.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia 84992|Acidimicrobiia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS MMS1_k127_1389174_1 105420.BBPO01000125_gene4703 2.394e-08 56.0 29BBV@1|root,2ZCHD@2|Bacteria,2I82W@201174|Actinobacteria,2NNJY@228398|Streptacidiphilus 201174|Actinobacteria S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA MMS1_k127_141283_0 101510.RHA1_ro05270 1.57e-147 475.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_29 MMS1_k127_141283_1 479432.Sros_0601 3.546e-131 426.0 COG3177@1|root,COG3177@2|Bacteria,2ICFW@201174|Actinobacteria,4EMKR@85012|Streptosporangiales 201174|Actinobacteria S Fic/DOC family - - - - - - - - - - - - Fic MMS1_k127_141283_3 1266925.JHVX01000002_gene993 5.134e-59 226.0 COG4715@1|root,COG4715@2|Bacteria,1R60K@1224|Proteobacteria 1224|Proteobacteria S Zinc finger, swim domain protein - - - - - - - - - - - - SWIM MMS1_k127_141283_4 590998.Celf_0170 8.318e-32 126.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 MMS1_k127_141283_2 590998.Celf_0171 4.018e-63 221.0 COG2801@1|root,COG2801@2|Bacteria,2GKW1@201174|Actinobacteria 201174|Actinobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_21,rve MMS1_k127_1470240_9 443143.GM18_1557 1.84e-30 132.0 COG3391@1|root,COG3637@1|root,COG4447@1|root,COG4886@1|root,COG3391@2|Bacteria,COG3637@2|Bacteria,COG4447@2|Bacteria,COG4886@2|Bacteria,1QXK5@1224|Proteobacteria 1224|Proteobacteria M repeat protein - - - - - - - - - - - - - MMS1_k127_1470240_5 525909.Afer_0299 1.426e-63 234.0 COG4227@1|root,COG4227@2|Bacteria,2I2PD@201174|Actinobacteria,4CNSA@84992|Acidimicrobiia 84992|Acidimicrobiia L IrrE N-terminal-like domain - - - - - - - - - - - - Peptidase_M78 MMS1_k127_1470240_11 68570.DC74_6211 2.425e-24 109.0 2FIHG@1|root,34A9I@2|Bacteria,2IFG8@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1470240_13 1121877.JQKF01000030_gene2177 7.49e-19 93.0 28Q31@1|root,2ZCKT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1470240_10 1121877.JQKF01000030_gene2176 5.762e-30 124.0 2DSTP@1|root,33HDH@2|Bacteria,2GTG0@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1470240_1 1121877.JQKF01000030_gene2175 2.08e-205 656.0 COG3505@1|root,COG3505@2|Bacteria,2GNQ7@201174|Actinobacteria 201174|Actinobacteria U Type IV secretory pathway VirD4 - - - - - - - - - - - - T4SS-DNA_transf,TraG-D_C MMS1_k127_1470240_2 1121877.JQKF01000030_gene2172 1.758e-191 616.0 COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria 201174|Actinobacteria U Type IV secretory pathway, VirB4 - - - - - - - - - - - - - MMS1_k127_1470240_3 1172188.KB911833_gene3899 2.571e-92 319.0 28IJ8@1|root,2Z8K6@2|Bacteria,2GIV3@201174|Actinobacteria,4FFF0@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - EccE MMS1_k127_1470240_14 710696.Intca_3108 4.326e-18 98.0 COG3266@1|root,COG3266@2|Bacteria,2GN4E@201174|Actinobacteria,4FK0P@85021|Intrasporangiaceae 201174|Actinobacteria S domain, Protein - - - - - - - - - - - - TrbL MMS1_k127_1470240_20 2074.JNYD01000007_gene1955 0.0002984 50.0 COG0739@1|root,COG0739@2|Bacteria,2GKXN@201174|Actinobacteria,4E2QB@85010|Pseudonocardiales 201174|Actinobacteria M heme binding - - - - - - - - - - - - - MMS1_k127_1470240_18 66875.JODY01000020_gene140 2.317e-06 53.0 2E3QT@1|root,32YNN@2|Bacteria,2IKY3@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1470240_12 675635.Psed_6072 8.026e-22 108.0 COG0455@1|root,COG4223@1|root,COG0455@2|Bacteria,COG4223@2|Bacteria,2GMK0@201174|Actinobacteria,4DXEP@85010|Pseudonocardiales 201174|Actinobacteria D ATPase involved in chromosome - - - - - - - - - - - - CbiA MMS1_k127_1470240_17 479431.Namu_4659 2.097e-06 61.0 COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria,4EVPW@85013|Frankiales 201174|Actinobacteria M peptidase C60 sortase A and B - - - - - - - - - - - - Sortase MMS1_k127_1470240_19 1236541.BALL01000011_gene1750 1.932e-05 57.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,2QAGA@267890|Shewanellaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS MMS1_k127_1470240_8 593907.Celgi_1316 4.43e-34 138.0 2BVF9@1|root,32QUP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1470240_4 1121946.AUAX01000029_gene2024 9.693e-70 249.0 2EIIK@1|root,33C9W@2|Bacteria,2IN3V@201174|Actinobacteria,4DKA0@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1470240_7 1120950.KB892796_gene2243 1.115e-41 160.0 COG1192@1|root,COG1192@2|Bacteria,2ICWE@201174|Actinobacteria,4DSPB@85009|Propionibacteriales 201174|Actinobacteria D VirC1 protein - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA MMS1_k127_1470240_6 1146883.BLASA_3961 5.306e-54 211.0 COG1475@1|root,COG1475@2|Bacteria,2I9VV@201174|Actinobacteria,4EVZQ@85013|Frankiales 201174|Actinobacteria K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc MMS1_k127_1470240_0 1121877.JQKF01000051_gene2667 0.0 1119.0 COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria 201174|Actinobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity - - - - - - - - - - - - AAA_30,TrwC MMS1_k127_1470240_16 1089547.KB913013_gene2606 4.203e-09 66.0 COG4914@1|root,COG4914@2|Bacteria,4NQC4@976|Bacteroidetes,47QAE@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - MMS1_k127_1470240_15 443143.GM18_1557 2.233e-09 67.0 COG3391@1|root,COG3637@1|root,COG4447@1|root,COG4886@1|root,COG3391@2|Bacteria,COG3637@2|Bacteria,COG4447@2|Bacteria,COG4886@2|Bacteria,1QXK5@1224|Proteobacteria 1224|Proteobacteria M repeat protein - - - - - - - - - - - - - MMS1_k127_1503886_4 1386089.N865_03210 1.326e-147 482.0 COG3039@1|root,COG3547@1|root,COG3039@2|Bacteria,COG3547@2|Bacteria,2HW75@201174|Actinobacteria 201174|Actinobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 MMS1_k127_1503886_18 1288298.rosmuc_04005 4.215e-09 63.0 COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,2UIEV@28211|Alphaproteobacteria,46RXA@74030|Roseovarius 28211|Alphaproteobacteria S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT MMS1_k127_1503886_14 2074.JNYD01000027_gene7332 6.221e-35 139.0 COG0346@1|root,COG0346@2|Bacteria,2IQB4@201174|Actinobacteria,4E5FV@85010|Pseudonocardiales 201174|Actinobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase MMS1_k127_1503886_17 1177594.MIC448_1150009 3.847e-09 60.0 2BD34@1|root,326QM@2|Bacteria,2HC94@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1503886_9 1229780.BN381_40095 1.47e-77 273.0 COG1680@1|root,COG1680@2|Bacteria,2HQYW@201174|Actinobacteria,3UXP0@52018|unclassified Actinobacteria (class) 2|Bacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase MMS1_k127_1503886_12 1313172.YM304_38880 3.216e-47 177.0 COG0461@1|root,COG0461@2|Bacteria,2HG8J@201174|Actinobacteria,4CN64@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - - MMS1_k127_1503886_8 1229780.BN381_130022 2.323e-86 306.0 COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,3UWBB@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F AIR synthase related protein, C-terminal domain purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016879,GO:0016882,GO:0044424,GO:0044444,GO:0044464 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C MMS1_k127_1503886_3 525909.Afer_1942 7.388e-153 496.0 COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4CMWP@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran MMS1_k127_1503886_13 1121438.JNJA01000002_gene3517 4.458e-38 157.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,42N9R@68525|delta/epsilon subdivisions,2WN5P@28221|Deltaproteobacteria,2M85C@213115|Desulfovibrionales 28221|Deltaproteobacteria S SMART phosphoesterase PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP MMS1_k127_1503886_19 931627.MycrhDRAFT_5657 6.825e-07 53.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,2382Y@1762|Mycobacteriaceae 201174|Actinobacteria L Transposase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon MMS1_k127_1503886_0 1229780.BN381_130019 3.101e-254 804.0 COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,3UWF7@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C MMS1_k127_1503886_15 525909.Afer_1951 2.499e-22 102.0 2A58G@1|root,30TXM@2|Bacteria,2HG9Z@201174|Actinobacteria,4CN8R@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_1503886_11 1137268.AZXF01000005_gene3187 1.098e-66 234.0 COG0262@1|root,COG0262@2|Bacteria,2GMZV@201174|Actinobacteria,4EIF7@85012|Streptosporangiales 201174|Actinobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C MMS1_k127_1503886_10 1229780.BN381_130016 1.078e-75 266.0 COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,3UWG1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 MMS1_k127_1503886_16 1229780.BN381_130015 7.208e-18 85.0 COG1828@1|root,COG1828@2|Bacteria 2|Bacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.2.6,6.3.5.3 ko:K01923,ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463,R04591 RC00010,RC00064,RC00162,RC01160 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU06460 PurS MMS1_k127_1503886_7 1229780.BN381_130013 4.153e-91 311.0 COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,3UWES@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F SAICAR synthetase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt MMS1_k127_1503886_5 1313172.YM304_38920 1.866e-133 438.0 COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4CMWU@84992|Acidimicrobiia 84992|Acidimicrobiia F Adenylosuccinate lyase C-terminus purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 MMS1_k127_1503886_6 1229780.BN381_130009 2.839e-116 388.0 COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,3UW9D@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Phosphoribosylglycinamide synthetase, C domain purD GO:0008150,GO:0040007 6.3.3.1,6.3.4.13 ko:K01945,ko:K11788 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04208 RC00090,RC00166,RC01100 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N MMS1_k127_1503886_1 1229780.BN381_130003 8.148e-203 638.0 COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,3UWF4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt MMS1_k127_1503886_2 1229780.BN381_240014 4.539e-192 608.0 COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,3UWFI@52018|unclassified Actinobacteria (class) 201174|Actinobacteria O Belongs to the ClpA ClpB family clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N MMS1_k127_1518237_16 1206730.BAGA01000170_gene2109 8.394e-08 64.0 2AP3H@1|root,31E51@2|Bacteria,2HHQM@201174|Actinobacteria,4FZP3@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1518237_6 926550.CLDAP_22590 1.208e-65 239.0 COG1473@1|root,COG1473@2|Bacteria,2G5WT@200795|Chloroflexi 200795|Chloroflexi S Peptidase dimerisation domain protein - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 MMS1_k127_1518237_11 391038.Bphy_2399 8.668e-32 138.0 COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2VVTJ@28216|Betaproteobacteria,1K0B0@119060|Burkholderiaceae 28216|Betaproteobacteria GK ROK family - - 2.7.1.63 ko:K00886 ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R02187,R02189 RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK MMS1_k127_1518237_13 525909.Afer_0206 1.664e-22 110.0 COG3505@1|root,COG3505@2|Bacteria,2HGPM@201174|Actinobacteria,4CNRX@84992|Acidimicrobiia 84992|Acidimicrobiia U TraM recognition site of TraD and TraG - - - ko:K03205 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS-DNA_transf MMS1_k127_1518237_10 1385519.N801_11050 3.093e-46 188.0 COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4FEPS@85021|Intrasporangiaceae 201174|Actinobacteria U Type IV secretory pathway, VirB4 - - - - - - - - - - - - - MMS1_k127_1518237_12 525909.Afer_0202 2.005e-25 109.0 2E3QT@1|root,31FNG@2|Bacteria,2HGTF@201174|Actinobacteria,4CNV3@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_1518237_4 525909.Afer_0201 1.535e-77 276.0 COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4CMZJ@84992|Acidimicrobiia 84992|Acidimicrobiia F His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07768 ko02020,map02020 M00443 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA MMS1_k127_1518237_5 1121877.JQKF01000025_gene831 4.46e-71 258.0 COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CMYH@84992|Acidimicrobiia 84992|Acidimicrobiia K Transcriptional regulatory protein, C terminal - - - ko:K07776 ko02020,map02020 M00443 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_1518237_0 525909.Afer_0190 1.95e-144 469.0 COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CMQR@84992|Acidimicrobiia 84992|Acidimicrobiia J Seryl-tRNA synthetase N-terminal domain serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b MMS1_k127_1518237_7 1229780.BN381_450049 2.503e-62 225.0 COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,3UX8B@52018|unclassified Actinobacteria (class) 201174|Actinobacteria V ATPases associated with a variety of cellular activities drrA_2 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1518237_8 106370.Francci3_1654 1.087e-58 224.0 COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4ESTT@85013|Frankiales 201174|Actinobacteria V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 MMS1_k127_1518237_14 1283283.ATXA01000010_gene4632 5.811e-14 79.0 COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4ET99@85013|Frankiales 201174|Actinobacteria CO Alkyl hydroperoxide reductase Thiol specific antioxidant ccsX - - - - - - - - - - - AhpC-TSA,Redoxin MMS1_k127_1518237_2 1121877.JQKF01000024_gene2406 5.044e-100 337.0 COG0109@1|root,COG0109@2|Bacteria,2GJMY@201174|Actinobacteria,4CMQ7@84992|Acidimicrobiia 84992|Acidimicrobiia O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA MMS1_k127_1518237_9 196162.Noca_2543 3.497e-48 186.0 COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4DQ6X@85009|Propionibacteriales 201174|Actinobacteria O cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA MMS1_k127_1518237_15 1449347.JQLN01000007_gene1835 1.225e-09 62.0 COG1290@1|root,COG1290@2|Bacteria,2GTS3@201174|Actinobacteria 201174|Actinobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - - MMS1_k127_1518237_3 525909.Afer_1523 1.082e-93 311.0 COG1290@1|root,COG1290@2|Bacteria,2GK58@201174|Actinobacteria,4CNNI@84992|Acidimicrobiia 84992|Acidimicrobiia C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - - MMS1_k127_1518237_1 981369.JQMJ01000004_gene589 1.154e-103 345.0 COG1290@1|root,COG1290@2|Bacteria,2GK58@201174|Actinobacteria,2NI2H@228398|Streptacidiphilus 201174|Actinobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - Cytochrom_B_N_2 MMS1_k127_1598945_1 469371.Tbis_3270 3.274e-82 284.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4DXK6@85010|Pseudonocardiales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1598945_0 1380390.JIAT01000015_gene5673 2.148e-95 329.0 COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4CSCX@84995|Rubrobacteria 84995|Rubrobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD MMS1_k127_1598945_2 1283299.AUKG01000002_gene4094 9.38e-10 70.0 2E44T@1|root,32Z0V@2|Bacteria,2HQIR@201174|Actinobacteria,4CS45@84995|Rubrobacteria 84995|Rubrobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_31 411490.ANACAC_03280 5.437e-29 117.0 2B9ZZ@1|root,323DM@2|Bacteria,1V6N4@1239|Firmicutes,24K1H@186801|Clostridia 186801|Clostridia S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - MMS1_k127_1641536_42 463191.SSEG_11128 4.554e-12 67.0 2DEPW@1|root,2ZNS6@2|Bacteria,2GWSK@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_33 1430440.MGMSRv2_1983 6.976e-22 96.0 2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_41 244582.JQAK01000022_gene652 2.13e-12 69.0 2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_46 591158.SSMG_04411 7.88e-09 59.0 2E4EA@1|root,3068J@2|Bacteria,2GZWZ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_29 1047013.AQSP01000121_gene2703 1.216e-34 134.0 2DMHR@1|root,32RMI@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_35 411466.ACTODO_00001 4.412e-16 79.0 2DMHR@1|root,32RMI@2|Bacteria,2HC0U@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_37 1122619.KB892364_gene1143 1.152e-14 74.0 2EK6X@1|root,33DXA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_34 411470.RUMGNA_02974 1.253e-20 91.0 2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,24Q9J@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - MMS1_k127_1641536_32 1125701.HMPREF1221_00764 1.574e-28 119.0 2DPM9@1|root,332MQ@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_0 1370121.AUWS01000016_gene7028 0.0 1064.0 COG1112@1|root,COG2251@1|root,COG4240@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,COG4240@2|Bacteria,2GMX8@201174|Actinobacteria,235G4@1762|Mycobacteriaceae 201174|Actinobacteria L nuclease - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,PDDEXK_1,RNase_H_2 MMS1_k127_1641536_4 1313172.YM304_20840 8.74e-140 459.0 COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4CMW7@84992|Acidimicrobiia 84992|Acidimicrobiia J Argininosuccinate lyase C-terminal argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 MMS1_k127_1641536_3 106370.Francci3_3169 5.657e-144 467.0 COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4ERIJ@85013|Frankiales 201174|Actinobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - iNJ661.Rv1658 Arginosuc_synth MMS1_k127_1641536_26 1229780.BN381_290119 1.249e-41 161.0 COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,3UWW0@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Arginine repressor, DNA binding domain argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C MMS1_k127_1641536_20 595460.RRSWK_05436 1.216e-55 208.0 COG0078@1|root,COG0078@2|Bacteria,2IX5M@203682|Planctomycetes 203682|Planctomycetes E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N MMS1_k127_1641536_25 1313172.YM304_20800 5.631e-44 171.0 COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CMYC@84992|Acidimicrobiia 84992|Acidimicrobiia F Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase MMS1_k127_1641536_8 1229780.BN381_290123 5.807e-96 330.0 COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,3UWGI@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC MMS1_k127_1641536_16 1123023.JIAI01000002_gene5197 4.34e-62 224.0 COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4E9DF@85010|Pseudonocardiales 201174|Actinobacteria EG EamA-like transporter family cyeA - - - - - - - - - - - EamA MMS1_k127_1641536_30 1283299.AUKG01000002_gene4998 3.2e-34 145.0 COG3884@1|root,COG3884@2|Bacteria,2H0CD@201174|Actinobacteria,4CQ6P@84995|Rubrobacteria 84995|Rubrobacteria I Acyl-ACP thioesterase - - - - - - - - - - - - Acyl-ACP_TE MMS1_k127_1641536_5 1313172.YM304_20720 8.052e-136 462.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4CMUN@84992|Acidimicrobiia 84992|Acidimicrobiia J B3/4 domain pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind MMS1_k127_1641536_7 525909.Afer_1674 5.966e-108 360.0 COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4CMPG@84992|Acidimicrobiia 84992|Acidimicrobiia J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d MMS1_k127_1641536_28 1122611.KB904007_gene7775 8.23e-35 143.0 COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4EH5S@85012|Streptosporangiales 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family tsnR - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind MMS1_k127_1641536_24 1229780.BN381_290130 2.838e-44 163.0 COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,3UWMY@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 MMS1_k127_1641536_39 1120950.KB892768_gene5218 2.56e-14 74.0 COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4DSQQ@85009|Propionibacteriales 201174|Actinobacteria J Ribosomal protein L35 rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p MMS1_k127_1641536_14 1313172.YM304_20650 2.985e-64 228.0 COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CMZR@84992|Acidimicrobiia 84992|Acidimicrobiia J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N MMS1_k127_1641536_44 1229780.BN381_290134 1.797e-10 67.0 2FH85@1|root,3492H@2|Bacteria,2H8HQ@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1641536_12 512565.AMIS_73820 7.918e-66 242.0 COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria,4D8YQ@85008|Micromonosporales 201174|Actinobacteria E ABC-type branched-chain amino acid transport systems, periplasmic component ilvJ - - - - - - - - - - - Peripla_BP_6 MMS1_k127_1641536_22 477641.MODMU_0536 1.788e-53 211.0 COG4177@1|root,COG4177@2|Bacteria,2GMGD@201174|Actinobacteria 201174|Actinobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1641536_17 710696.Intca_3203 1.498e-61 223.0 COG0559@1|root,COG0559@2|Bacteria,2HDZ9@201174|Actinobacteria 201174|Actinobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1641536_11 471857.Svir_23010 7.765e-70 244.0 COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4E305@85010|Pseudonocardiales 201174|Actinobacteria E Branched-chain amino acid transport - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS1_k127_1641536_10 710696.Intca_3205 3.175e-74 257.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4FFTD@85021|Intrasporangiaceae 201174|Actinobacteria E COG0411 ABC-type branched-chain amino acid transport systems ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS1_k127_1641536_27 525367.HMPREF0556_11907 1.704e-38 151.0 COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli 91061|Bacilli H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08940 DMRL_synthase MMS1_k127_1641536_1 1121877.JQKF01000023_gene2239 2.946e-163 526.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4CN1A@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 MMS1_k127_1641536_9 1229780.BN381_50158 1.155e-89 311.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,3UWIW@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 MMS1_k127_1641536_15 1430331.EP10_16745 1.76e-63 225.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1WE4J@129337|Geobacillus 91061|Bacilli G Ribulose-phosphate 3 epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim MMS1_k127_1641536_18 1313172.YM304_20570 3.163e-60 220.0 COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4CN6M@84992|Acidimicrobiia 84992|Acidimicrobiia J Formyl transferase, C-terminal domain fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N MMS1_k127_1641536_21 1229780.BN381_50154 1.083e-54 196.0 COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,3UWS7@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase MMS1_k127_1641536_47 1449353.JQMQ01000005_gene832 1.436e-08 68.0 COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,2NEJE@228398|Streptacidiphilus 201174|Actinobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - - MMS1_k127_1641536_2 608506.COB47_0634 1.075e-162 521.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,42ESY@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N MMS1_k127_1641536_6 1229780.BN381_50149 1.258e-118 394.0 COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,3UWCS@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein MMS1_k127_1641536_48 1828.JOKB01000065_gene4469 3.963e-08 62.0 COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4G25E@85025|Nocardiaceae 201174|Actinobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 MMS1_k127_1641536_23 1313172.YM304_20490 6.345e-52 193.0 COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CN5V@84992|Acidimicrobiia 84992|Acidimicrobiia F Guanylate kinase homologues. gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin MMS1_k127_1641536_38 1223544.GSI01S_03_00280 1.171e-14 79.0 COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4GEH2@85026|Gordoniaceae 201174|Actinobacteria J integration host factor mihF - - - - - - - - - - - - MMS1_k127_1641536_13 882086.SacxiDRAFT_0295 5.435e-65 233.0 COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria,4DXGR@85010|Pseudonocardiales 201174|Actinobacteria F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase MMS1_k127_1641536_19 1313172.YM304_20470 1.916e-58 209.0 COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CN0R@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the conversion of dihydroorotate to orotate pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh MMS1_k127_164890_12 530564.Psta_2360 1.555e-63 228.0 COG0181@1|root,COG0181@2|Bacteria,2IZ4I@203682|Planctomycetes 203682|Planctomycetes H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC MMS1_k127_164890_13 1449069.JMLO01000005_gene1550 2.722e-63 233.0 COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4FUGW@85025|Nocardiaceae 201174|Actinobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0008150,GO:0040007 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH MMS1_k127_164890_19 452652.KSE_33640 1.508e-45 173.0 COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,2M0T9@2063|Kitasatospora 201174|Actinobacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N MMS1_k127_164890_15 1229780.BN381_60047 9.738e-57 207.0 COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,3UWS1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer MMS1_k127_164890_22 28042.GU90_05985 6.146e-07 59.0 2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria,4E2K5@85010|Pseudonocardiales 201174|Actinobacteria S Putative bacterial sensory transduction regulator - - - - - - - - - - - - YbjN MMS1_k127_164890_3 1313172.YM304_37900 7.327e-109 365.0 COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4CMYV@84992|Acidimicrobiia 84992|Acidimicrobiia M Glycosyl transferase 4-like domain - - 2.4.1.250 ko:K15521 - - - - ko00000,ko01000 - - - Glyco_transf_4,Glycos_transf_1 MMS1_k127_164890_23 1123023.JIAI01000007_gene2016 7.159e-07 60.0 COG0681@1|root,COG0681@2|Bacteria,2GQUN@201174|Actinobacteria,4ED5N@85010|Pseudonocardiales 201174|Actinobacteria U Peptidase S24-like - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 MMS1_k127_164890_17 298655.KI912266_gene2059 6.015e-52 188.0 293MU@1|root,2ZR3M@2|Bacteria,2IFCB@201174|Actinobacteria,4ESJ1@85013|Frankiales 201174|Actinobacteria Q Superoxide dismutase sodN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.15.1.1 ko:K00518 - - - - ko00000,ko01000 - - - Sod_Ni MMS1_k127_164890_20 58344.JOEL01000052_gene6119 3.222e-11 75.0 COG3595@1|root,COG3595@2|Bacteria,2GJZC@201174|Actinobacteria 201174|Actinobacteria S Putative adhesin - - - - - - - - - - - - DUF4097 MMS1_k127_164890_21 1043205.AFYF01000077_gene1678 6.103e-09 63.0 COG4226@1|root,COG4226@2|Bacteria,2IKXB@201174|Actinobacteria,4FGBM@85021|Intrasporangiaceae 201174|Actinobacteria S protein encoded in hypervariable junctions of pilus gene clusters - - - - - - - - - - - - HicB,RHH_1 MMS1_k127_164890_24 397278.JOJN01000010_gene2223 7.018e-06 51.0 COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DRE5@85009|Propionibacteriales 201174|Actinobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR MMS1_k127_164890_0 1121877.JQKF01000014_gene45 5.509e-292 909.0 COG0365@1|root,COG0365@2|Bacteria,2IDBD@201174|Actinobacteria,4CNHW@84992|Acidimicrobiia 84992|Acidimicrobiia I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C MMS1_k127_164890_16 1048339.KB913029_gene3207 1.369e-54 196.0 COG2030@1|root,COG2030@2|Bacteria,2HFAT@201174|Actinobacteria,4ET8D@85013|Frankiales 201174|Actinobacteria I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas MMS1_k127_164890_8 1298880.AUEV01000010_gene2813 1.788e-86 292.0 COG1309@1|root,COG1309@2|Bacteria,2IA2T@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_164890_4 1323361.JPOC01000022_gene2997 1.456e-102 348.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FWS1@85025|Nocardiaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 MMS1_k127_164890_14 1223544.GSI01S_42_00320 4.98e-60 218.0 COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4GEY8@85026|Gordoniaceae 201174|Actinobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE MMS1_k127_164890_9 1089544.KB912942_gene1237 1.187e-81 279.0 COG2188@1|root,COG2188@2|Bacteria,2GKMH@201174|Actinobacteria,4E1DD@85010|Pseudonocardiales 201174|Actinobacteria K UTRA - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA MMS1_k127_164890_6 1476876.JOJO01000030_gene3181 4.022e-97 328.0 COG0668@1|root,COG0668@2|Bacteria,2GZI1@201174|Actinobacteria 201174|Actinobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel,cNMP_binding MMS1_k127_164890_18 1111479.AXAR01000002_gene1839 9.962e-51 187.0 COG1335@1|root,COG1335@2|Bacteria,1U4IN@1239|Firmicutes,4HE4U@91061|Bacilli 91061|Bacilli Q Isochorismatase family - - - - - - - - - - - - Isochorismatase MMS1_k127_164890_7 1306174.JODP01000010_gene6883 5.535e-88 295.0 COG1309@1|root,COG1309@2|Bacteria,2GM0B@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N MMS1_k127_164890_5 1214242.B446_02585 9.484e-101 341.0 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_164890_2 1382306.JNIM01000001_gene2102 3.063e-144 464.0 COG1063@1|root,COG1063@2|Bacteria,2G7RW@200795|Chloroflexi 200795|Chloroflexi C PFAM Alcohol dehydrogenase zinc-binding domain protein - - - - - - - - - - - - ADH_N,ADH_zinc_N MMS1_k127_164890_11 1121017.AUFG01000005_gene965 1.009e-65 232.0 COG1917@1|root,COG1917@2|Bacteria,2IFSF@201174|Actinobacteria,4FGJ5@85021|Intrasporangiaceae 201174|Actinobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 MMS1_k127_164890_1 1828.JOKB01000012_gene5467 9.046e-184 579.0 COG2141@1|root,COG2141@2|Bacteria,2GNR5@201174|Actinobacteria,4FUEW@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase MMS1_k127_164890_10 644283.Micau_0013 8.996e-76 271.0 COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4DC3C@85008|Micromonosporales 201174|Actinobacteria L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase MMS1_k127_164890_25 1054860.KB913030_gene3599 2.064e-05 51.0 COG3311@1|root,COG3311@2|Bacteria 2|Bacteria K DNA excision - - - - - - - - - - - - HTH_17 MMS1_k127_1686519_5 525909.Afer_0947 1.159e-205 651.0 COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CMVH@84992|Acidimicrobiia 84992|Acidimicrobiia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS MMS1_k127_1686519_25 1121877.JQKF01000002_gene1673 9.18e-95 323.0 COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4CMYT@84992|Acidimicrobiia 84992|Acidimicrobiia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG MMS1_k127_1686519_21 1121877.JQKF01000002_gene1672 5.944e-122 408.0 COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CMXX@84992|Acidimicrobiia 84992|Acidimicrobiia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF MMS1_k127_1686519_68 626522.GCWU000325_00655 2.906e-10 65.0 COG1862@1|root,COG1862@2|Bacteria,4NUT4@976|Bacteroidetes,2FSSK@200643|Bacteroidia,1WDJB@1283313|Alloprevotella 976|Bacteroidetes U Preprotein translocase subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC MMS1_k127_1686519_22 1313172.YM304_19880 6.581e-117 385.0 COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CMVN@84992|Acidimicrobiia 84992|Acidimicrobiia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N MMS1_k127_1686519_60 518637.EUBIFOR_00378 2.59e-28 127.0 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,3VQJ5@526524|Erysipelotrichia 526524|Erysipelotrichia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N MMS1_k127_1686519_56 1313172.YM304_19860 3.084e-35 140.0 COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4CNAX@84992|Acidimicrobiia 84992|Acidimicrobiia L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC MMS1_k127_1686519_27 1121877.JQKF01000002_gene1651 2.554e-91 306.0 COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4CMY7@84992|Acidimicrobiia 84992|Acidimicrobiia K Transcriptional regulator - - - - - - - - - - - - Transcrip_reg MMS1_k127_1686519_40 298655.KI912266_gene5214 7.691e-56 201.0 COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4ESCW@85013|Frankiales 201174|Actinobacteria H Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS pdxT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SNO MMS1_k127_1686519_14 1313172.YM304_19820 6.353e-137 440.0 COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CMSX@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ MMS1_k127_1686519_67 525909.Afer_1222 1.477e-10 72.0 2BAXV@1|root,324DK@2|Bacteria,2HH2X@201174|Actinobacteria,4CP32@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_1686519_51 1229780.BN381_50176 1.219e-44 177.0 COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,3UXCT@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Glycosyltransferase Family 4 pimA GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 ko:K08256 - - R11702 - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4 MMS1_k127_1686519_39 1229780.BN381_50175 7.575e-57 214.0 COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,3UXIQ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Bacterial lipid A biosynthesis acyltransferase htrB GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 ko:K22311 - - - - ko00000,ko01000 - - - Lip_A_acyltrans MMS1_k127_1686519_45 1313172.YM304_19750 1.096e-49 184.0 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4CN1P@84992|Acidimicrobiia 84992|Acidimicrobiia I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf MMS1_k127_1686519_55 453591.Igni_1404 1.593e-40 156.0 COG0537@1|root,arCOG00419@2157|Archaea,2XQK8@28889|Crenarchaeota 28889|Crenarchaeota F PFAM histidine triad (HIT) protein - - 2.7.7.53 ko:K19710 ko00230,map00230 - R00126,R01618 RC00002,RC02753,RC02795 ko00000,ko00001,ko01000 - - - HIT MMS1_k127_1686519_4 471852.Tcur_2095 1.937e-222 707.0 COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4EG5V@85012|Streptosporangiales 201174|Actinobacteria J Threonyl and Alanyl tRNA synthetase second additional domain thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD MMS1_k127_1686519_10 1229780.BN381_50169 3.302e-148 488.0 COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,3UX20@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J tRNA synthetases class I (C) catalytic domain mshC GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16,6.3.1.13 ko:K01883,ko:K15526 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1e MMS1_k127_1686519_46 1229780.BN381_50168 3.13e-49 183.0 COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria 201174|Actinobacteria S PFAM NADP oxidoreductase coenzyme F420-dependent npdG - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored MMS1_k127_1686519_31 1313172.YM304_19680 1.64e-80 287.0 COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4CMWN@84992|Acidimicrobiia 84992|Acidimicrobiia I Enoyl-(Acyl carrier protein) reductase - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 MMS1_k127_1686519_3 1122611.KB904018_gene6878 1.314e-223 710.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EFP3@85012|Streptosporangiales 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran MMS1_k127_1686519_44 105422.BBPM01000070_gene363 7.99e-50 190.0 COG1280@1|root,COG1280@2|Bacteria,2GMDP@201174|Actinobacteria,2NI6Y@228398|Streptacidiphilus 201174|Actinobacteria E LysE type translocator - - - - - - - - - - - - LysE MMS1_k127_1686519_43 1121352.JHZP01000004_gene1510 1.07e-50 187.0 COG2364@1|root,COG2364@2|Bacteria,1QZWW@1224|Proteobacteria,2VS10@28216|Betaproteobacteria,2KR80@206351|Neisseriales 206351|Neisseriales S membrane - - - ko:K07149 - - - - ko00000 - - - - MMS1_k127_1686519_12 1206741.BAFX01000118_gene7358 3.333e-139 459.0 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FX8C@85025|Nocardiaceae 201174|Actinobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 MMS1_k127_1686519_9 208444.JNYY01000033_gene5826 3.492e-152 496.0 COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4DX9Q@85010|Pseudonocardiales 201174|Actinobacteria L DNA RNA helicase, superfamily II rhlE1 - - - - - - - - - - - DEAD,Helicase_C MMS1_k127_1686519_61 367299.JOEE01000001_gene1533 1.047e-27 122.0 COG2141@1|root,COG2141@2|Bacteria,2GPKW@201174|Actinobacteria 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - - MMS1_k127_1686519_66 765420.OSCT_2237 8.777e-12 75.0 COG3153@1|root,COG3153@2|Bacteria 2|Bacteria S transferase activity, transferring acyl groups - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_1686519_62 649638.Trad_0966 7.283e-27 113.0 COG3795@1|root,COG3795@2|Bacteria 2|Bacteria F YCII-related domain - - - - - - - - - - - - YCII MMS1_k127_1686519_28 219305.MCAG_02726 2.089e-89 306.0 COG4427@1|root,COG4427@2|Bacteria,2HVQW@201174|Actinobacteria,4DB6Z@85008|Micromonosporales 201174|Actinobacteria S Uncharacterized protein conserved in bacteria (DUF2332) - - - - - - - - - - - - DUF2332 MMS1_k127_1686519_52 525909.Afer_1429 3.243e-42 164.0 COG0204@1|root,COG0204@2|Bacteria,2IAXZ@201174|Actinobacteria,4CN1J@84992|Acidimicrobiia 84992|Acidimicrobiia I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase MMS1_k127_1686519_42 263358.VAB18032_26851 1.628e-51 199.0 COG3442@1|root,COG3442@2|Bacteria,2GKPV@201174|Actinobacteria,4DB13@85008|Micromonosporales 201174|Actinobacteria S glutamine amidotransferase cobQ2 - - ko:K07009 - - - - ko00000 - - - GATase_3 MMS1_k127_1686519_26 1169154.KB897786_gene1556 2.32e-93 320.0 COG0771@1|root,COG0771@2|Bacteria,2GK18@201174|Actinobacteria 201174|Actinobacteria M Mur ligase, middle domain protein murE - - - - - - - - - - - DUF1727,Mur_ligase_M MMS1_k127_1686519_35 1229780.BN381_430035 2.636e-61 223.0 COG0583@1|root,COG0583@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate MMS1_k127_1686519_59 349163.Acry_2635 2.51e-32 134.0 COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2UA13@28211|Alphaproteobacteria,2JX9Y@204441|Rhodospirillales 204441|Rhodospirillales L endonuclease III - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD MMS1_k127_1686519_13 994479.GL877880_gene3919 1.397e-137 451.0 COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4E03A@85010|Pseudonocardiales 201174|Actinobacteria E PFAM Peptidase family M20 M25 M40 - - - - - - - - - - - - M20_dimer,Peptidase_M20 MMS1_k127_1686519_11 1313172.YM304_25510 3.461e-147 479.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4CNFE@84992|Acidimicrobiia 84992|Acidimicrobiia I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_1686519_33 1463845.JOIG01000005_gene3426 6.033e-76 261.0 COG0512@1|root,COG0512@2|Bacteria,2GJUX@201174|Actinobacteria 201174|Actinobacteria EH Glutamine amidotransferase of anthranilate synthase trpG GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase MMS1_k127_1686519_19 926561.KB900620_gene2997 4.397e-125 417.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WBGE@53433|Halanaerobiales 186801|Clostridia EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind MMS1_k127_1686519_0 1313172.YM304_16690 4.443e-247 773.0 COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMUP@84992|Acidimicrobiia 84992|Acidimicrobiia I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase MMS1_k127_1686519_47 1313172.YM304_30600 2.649e-48 176.0 COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia 201174|Actinobacteria I B12 binding domain icmB - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding MMS1_k127_1686519_16 1449353.JQMQ01000005_gene590 9.156e-132 439.0 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,2NHHA@228398|Streptacidiphilus 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_1686519_15 452637.Oter_0981 3.059e-134 443.0 COG2070@1|root,COG2070@2|Bacteria,46UTY@74201|Verrucomicrobia,3K79P@414999|Opitutae 414999|Opitutae C Nitronate monooxygenase - - - - - - - - - - - - NMO MMS1_k127_1686519_1 2074.JNYD01000016_gene4216 4.643e-234 736.0 COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4DZ57@85010|Pseudonocardiales 201174|Actinobacteria I synthetase - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C MMS1_k127_1686519_64 1449346.JQMO01000003_gene4341 7.192e-22 111.0 COG1289@1|root,COG1289@2|Bacteria,2GN5P@201174|Actinobacteria,2M1N8@2063|Kitasatospora 201174|Actinobacteria S FUSC-like inner membrane protein yccS yccS_3 - - - - - - - - - - - FUSC-like,FUSC_2 MMS1_k127_1686519_49 1343740.M271_21795 6.81e-47 172.0 COG1970@1|root,COG1970@2|Bacteria,2IQDN@201174|Actinobacteria 201174|Actinobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL MMS1_k127_1686519_65 525909.Afer_1833 9.413e-19 98.0 COG2246@1|root,COG2246@2|Bacteria,2HGRJ@201174|Actinobacteria,4CNUB@84992|Acidimicrobiia 84992|Acidimicrobiia S GtrA-like protein - - - - - - - - - - - - GtrA MMS1_k127_1686519_57 258052.JNYV01000010_gene3258 4.61e-35 136.0 COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,2M3EG@2063|Kitasatospora 201174|Actinobacteria S Metal-sensitive transcriptional repressor csoR - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal MMS1_k127_1686519_69 593907.Celgi_0128 4.143e-10 63.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria 201174|Actinobacteria P Heavy metal translocating P-type atpase - - 3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54 ko:K01533,ko:K01534,ko:K12954,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3,3.A.3.5,3.A.3.6 - - Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS MMS1_k127_1686519_58 1157638.KB892164_gene3402 1.512e-33 141.0 COG0697@1|root,COG0697@2|Bacteria,2GRXH@201174|Actinobacteria 201174|Actinobacteria EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - - MMS1_k127_1686519_38 479432.Sros_4461 2.738e-57 205.0 COG1670@1|root,COG1670@2|Bacteria,2GNYE@201174|Actinobacteria,4EIHX@85012|Streptosporangiales 201174|Actinobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 MMS1_k127_1686519_70 1289387.AUKW01000026_gene4777 3.991e-05 55.0 2DPU0@1|root,333DA@2|Bacteria,2GNE1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1686519_48 365528.KB891110_gene1715 2.342e-47 179.0 COG1309@1|root,COG1309@2|Bacteria,2IP3P@201174|Actinobacteria,4EWM6@85013|Frankiales 201174|Actinobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N MMS1_k127_1686519_7 1206731.BAGB01000023_gene1222 3.062e-178 572.0 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4G5I0@85025|Nocardiaceae 201174|Actinobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 MMS1_k127_1686519_50 84531.JMTZ01000030_gene161 1.394e-45 172.0 COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,1T2HX@1236|Gammaproteobacteria,1XD5V@135614|Xanthomonadales 135614|Xanthomonadales S Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2 MMS1_k127_1686519_37 1230476.C207_05565 2.113e-60 216.0 COG0410@1|root,COG0410@2|Bacteria,1R89S@1224|Proteobacteria,2U393@28211|Alphaproteobacteria,3JX6F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ABC transporter - - - - - - - - - - - - ABC_tran MMS1_k127_1686519_36 1040989.AWZU01000012_gene1322 8.676e-61 218.0 COG0411@1|root,COG0411@2|Bacteria,1R6TG@1224|Proteobacteria,2U47J@28211|Alphaproteobacteria,3JWB8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran MMS1_k127_1686519_29 426114.THI_1172 3.615e-89 306.0 COG4177@1|root,COG4177@2|Bacteria,1N76B@1224|Proteobacteria,2VKFH@28216|Betaproteobacteria 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1686519_30 1159870.KB907784_gene2759 8.745e-85 289.0 COG0559@1|root,COG0559@2|Bacteria,1MXHF@1224|Proteobacteria,2VUM8@28216|Betaproteobacteria,3T71Z@506|Alcaligenaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_1686519_23 1051632.TPY_2455 1.497e-103 351.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS1_k127_1686519_2 1382306.JNIM01000001_gene3130 3.262e-229 725.0 COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi 2|Bacteria H Thiamine pyrophosphate protein TPP binding domain protein ilvB2 - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N MMS1_k127_1686519_17 208439.AJAP_09315 4.501e-129 428.0 COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4E2NS@85010|Pseudonocardiales 201174|Actinobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN MMS1_k127_1686519_20 1416759.AYMR01000005_gene3694 5.701e-123 402.0 COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4FMM8@85023|Microbacteriaceae 201174|Actinobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red MMS1_k127_1686519_53 331869.BAL199_24114 9.086e-42 167.0 COG1082@1|root,COG1082@2|Bacteria,1N0QZ@1224|Proteobacteria,2UDUZ@28211|Alphaproteobacteria,4BSD5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Xylose isomerase-like TIM barrel - - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 MMS1_k127_1686519_24 1265310.CCBD010000086_gene4725 1.809e-103 357.0 COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria,236BQ@1762|Mycobacteriaceae 201174|Actinobacteria C Succinate dehydrogenase fumarate reductase flavoprotein subunit - - - - - - - - - - - - FAD_binding_2 MMS1_k127_1686519_18 1122919.KB905575_gene3456 1.457e-128 426.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,26R6D@186822|Paenibacillaceae 91061|Bacilli C Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively gabD - - - - - - - - - - - Aldedh MMS1_k127_1686519_8 1077972.ARGLB_039_00400 6.766e-174 562.0 COG1053@1|root,COG1053@2|Bacteria 2|Bacteria C succinate dehydrogenase - - - - - - - - - - - - FAD_binding_2 MMS1_k127_1686519_6 1283283.ATXA01000008_gene3037 3.703e-194 618.0 COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria,4EVS2@85013|Frankiales 201174|Actinobacteria C FAD binding domain - - - ko:K13796 - - - - ko00000 - - - FAD_binding_2 MMS1_k127_1686519_32 1283283.ATXA01000008_gene3038 2.324e-80 281.0 COG1149@1|root,COG1149@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding tcuB - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388,ko:K13795 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Pyr_redox_2 MMS1_k127_1686519_54 1380347.JNII01000005_gene3353 3.028e-41 165.0 COG4702@1|root,COG4702@2|Bacteria,2IFGG@201174|Actinobacteria 201174|Actinobacteria S Belongs to the UPF0303 family - - - - - - - - - - - - Haem_degrading MMS1_k127_1686519_34 1123023.JIAI01000001_gene7443 6.576e-63 222.0 COG1802@1|root,COG1802@2|Bacteria,2IMDH@201174|Actinobacteria,4E72S@85010|Pseudonocardiales 201174|Actinobacteria K FCD - - - - - - - - - - - - FCD,GntR MMS1_k127_1686519_63 697282.Mettu_2750 9.287e-27 122.0 2DP71@1|root,330U0@2|Bacteria,1R5A0@1224|Proteobacteria,1RS7S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2971) - - - - - - - - - - - - DUF2971 MMS1_k127_1686519_41 1147.D082_05700 1.208e-53 209.0 COG3344@1|root,COG3344@2|Bacteria,1GIIQ@1117|Cyanobacteria,1H6SD@1142|Synechocystis 1117|Cyanobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 MMS1_k127_1686519_71 1206739.BAGJ01000262_gene2901 0.0003596 49.0 2BJ0Z@1|root,32D9J@2|Bacteria,2HJ3K@201174|Actinobacteria,4G58W@85025|Nocardiaceae 201174|Actinobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 MMS1_k127_175435_2 1246995.AFR_02945 4.299e-25 119.0 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity - - - ko:K20468 - - - - ko00000,ko02000 4.D.2.4.1 - - LPG_synthase_TM MMS1_k127_175435_0 1210908.HSB1_39720 8.638e-237 754.0 COG3119@1|root,arCOG02791@2157|Archaea,2Y8G8@28890|Euryarchaeota,23VJY@183963|Halobacteria 183963|Halobacteria P Sulfatase - - - - - - - - - - - - Sulfatase MMS1_k127_175435_1 1146883.BLASA_3642 2.709e-147 489.0 COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria,4ESRY@85013|Frankiales 201174|Actinobacteria M PFAM Glycosyl transferase family 2 bcsA - 2.4.1.12 ko:K00694 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2,PilZ MMS1_k127_175435_3 1172180.KB911775_gene6400 4.076e-11 68.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 MMS1_k127_1851576_0 1089549.AZUQ01000001_gene2196 4.458e-73 256.0 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria 201174|Actinobacteria L Transposase tnpA - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 MMS1_k127_1851576_2 1254432.SCE1572_36075 2.231e-45 178.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42VXX@68525|delta/epsilon subdivisions,2X6CT@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 MMS1_k127_1851576_3 1193181.BN10_1540003 6.545e-24 106.0 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4FF8P@85021|Intrasporangiaceae 201174|Actinobacteria L zinc-finger of transposase IS204/IS1001/IS1096/IS1165 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 MMS1_k127_1851576_1 1504672.669787675 2.327e-50 192.0 COG4974@1|root,COG4974@2|Bacteria,1MZES@1224|Proteobacteria,2VU6S@28216|Betaproteobacteria,4AHYI@80864|Comamonadaceae 28216|Betaproteobacteria L Plasmid pRiA4b ORF-3-like protein - - - - - - - - - - - - PRiA4_ORF3 MMS1_k127_1851576_4 1380356.JNIK01000014_gene3361 8.774e-06 49.0 COG0454@1|root,COG0456@2|Bacteria,2IIFA@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 MMS1_k127_1876889_6 926554.KI912675_gene2133 6.444e-81 286.0 COG1940@1|root,COG1940@2|Bacteria,1WJ6H@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus GK Transcriptional regulator sugar kinase - - - - - - - - - - - - HTH_24,ROK MMS1_k127_1876889_5 1094508.Tsac_2301 1.479e-81 285.0 COG3387@1|root,COG3387@2|Bacteria,1TR12@1239|Firmicutes,248Q3@186801|Clostridia 186801|Clostridia G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - Glyco_hydro_15 MMS1_k127_1876889_9 1304865.JAGF01000001_gene1457 1.095e-64 238.0 COG2182@1|root,COG2182@2|Bacteria,2I2J8@201174|Actinobacteria 201174|Actinobacteria G Extracellular solute-binding protein malE - - ko:K15770 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.16,3.A.1.1.2 - - SBP_bac_1,SBP_bac_8 MMS1_k127_1876889_8 1203556.HMPREF1478_01050 5.18e-68 242.0 COG1175@1|root,COG1175@2|Bacteria,2GKBJ@201174|Actinobacteria,4D83I@85005|Actinomycetales 201174|Actinobacteria P ABC transporter permease - - - ko:K02025,ko:K05814,ko:K10118 ko02010,map02010 M00196,M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28,3.A.1.1.3 - - BPD_transp_1 MMS1_k127_1876889_12 411466.ACTODO_01109 9.392e-57 209.0 COG0395@1|root,COG0395@2|Bacteria,2GMTH@201174|Actinobacteria,4D60B@85005|Actinomycetales 201174|Actinobacteria P ABC transporter permease - - - - - - - - - - - - BPD_transp_1 MMS1_k127_1876889_16 158190.SpiGrapes_2566 4.174e-37 160.0 COG5297@1|root,COG5297@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.11 ko:K05988 ko00500,map00500 - R11309 - ko00000,ko00001,ko01000 - GH66 - CotH,Glyco_hydro_66 MMS1_k127_1876889_2 1121877.JQKF01000012_gene316 1.009e-136 451.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4CMW3@84992|Acidimicrobiia 84992|Acidimicrobiia E ATPases associated with a variety of cellular activities - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran MMS1_k127_1876889_14 345341.KUTG_01256 7.354e-52 190.0 COG0645@1|root,COG0645@2|Bacteria,2IM2M@201174|Actinobacteria 201174|Actinobacteria S AAA domain - - - - - - - - - - - - AAA_33 MMS1_k127_1876889_17 1101188.KI912155_gene1418 6.636e-22 96.0 2E3V5@1|root,32YSE@2|Bacteria,2GQM1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - HTH_11,HTH_23 MMS1_k127_1876889_21 1306174.JODP01000001_gene5291 1.143e-13 79.0 COG0542@1|root,COG0542@2|Bacteria,2IM0U@201174|Actinobacteria 201174|Actinobacteria O Clp amino terminal domain, pathogenicity island component - - - - - - - - - - - - Clp_N MMS1_k127_1876889_19 330084.JNYZ01000029_gene94 1.357e-18 88.0 2BWPS@1|root,345TK@2|Bacteria,2H99A@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1876889_0 525909.Afer_1061 2.653e-185 595.0 COG0477@1|root,COG2814@2|Bacteria,2I2ZF@201174|Actinobacteria,4CNM3@84992|Acidimicrobiia 84992|Acidimicrobiia EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 MMS1_k127_1876889_3 656024.FsymDg_2065 6.49e-122 400.0 COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase MMS1_k127_1876889_11 390989.JOEG01000003_gene4661 2.303e-58 218.0 COG2211@1|root,COG2211@2|Bacteria,2GP5J@201174|Actinobacteria,4D8EN@85008|Micromonosporales 201174|Actinobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like MMS1_k127_1876889_22 981369.JQMJ01000004_gene1773 7.487e-05 55.0 COG2755@1|root,COG2755@2|Bacteria,2GRDF@201174|Actinobacteria,2NF42@228398|Streptacidiphilus 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 MMS1_k127_1876889_10 235985.BBPN01000045_gene8062 6.572e-64 226.0 COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,2NIW2@228398|Streptacidiphilus 201174|Actinobacteria S Phosphoribosyl transferase domain - - - ko:K07100 - - - - ko00000 - - - DLH,Pribosyltran MMS1_k127_1876889_15 1211815.CBYP010000044_gene388 1.512e-44 177.0 COG5542@1|root,COG5542@2|Bacteria,2HJW5@201174|Actinobacteria,4ETD2@85013|Frankiales 201174|Actinobacteria S integral membrane protein - - - - - - - - - - - - Mannosyl_trans2 MMS1_k127_1876889_13 1306990.BARG01000031_gene3427 8.427e-55 211.0 2AMJ0@1|root,31CER@2|Bacteria,2I3ZG@201174|Actinobacteria 201174|Actinobacteria - - - - - ko:K14337,ko:K14339 - - - - ko00000,ko01000,ko01003 - - - GT87 MMS1_k127_1876889_7 1313172.YM304_36700 2.14e-72 255.0 COG0208@1|root,COG0208@2|Bacteria,2GKGZ@201174|Actinobacteria 201174|Actinobacteria F PFAM Fatty acid desaturase, type 2 desA - 1.14.19.11,1.14.19.2,1.14.19.26 ko:K03921 ko00061,ko01040,ko01212,map00061,map01040,map01212 - R03370,R08161,R11108,R11109 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase_2 MMS1_k127_1876889_1 469371.Tbis_2032 4.533e-159 519.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZW9@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K16029 ko01051,ko01052,map01051,map01052 - - - ko00000,ko00001 - - - AMP-binding,AMP-binding_C MMS1_k127_1876889_18 134676.ACPL_874 1.502e-21 99.0 COG1051@1|root,COG1051@2|Bacteria,2IBER@201174|Actinobacteria,4DAA2@85008|Micromonosporales 201174|Actinobacteria F Nudix hydrolase - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX MMS1_k127_1876889_4 316278.SynRCC307_2184 8.756e-118 395.0 COG0701@1|root,COG3350@1|root,COG0701@2|Bacteria,COG3350@2|Bacteria,1G4BX@1117|Cyanobacteria 1117|Cyanobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 MMS1_k127_1876889_20 2045.KR76_16095 7.921e-15 74.0 COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4DNVW@85009|Propionibacteriales 201174|Actinobacteria C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1894135_1 479431.Namu_0594 9.111e-123 404.0 COG0210@1|root,COG0210@2|Bacteria,2IF81@201174|Actinobacteria,4EUVM@85013|Frankiales 201174|Actinobacteria L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C MMS1_k127_1894135_0 1123320.KB889566_gene5764 2.92e-316 1003.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria 201174|Actinobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C MMS1_k127_1929709_0 1304865.JAGF01000001_gene3291 7.044e-212 682.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4F1XR@85016|Cellulomonadaceae 201174|Actinobacteria P E1-E2 ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hemerythrin,Hydrolase MMS1_k127_1929709_5 106370.Francci3_0182 8.221e-43 166.0 COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4EV7V@85013|Frankiales 201174|Actinobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase MMS1_k127_1929709_6 446469.Sked_12900 1.062e-15 82.0 COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria 201174|Actinobacteria S Uncharacterized conserved protein (DUF2277) - - - - - - - - - - - - DUF2277 MMS1_k127_1929709_3 1120950.KB892756_gene6691 1.459e-71 264.0 COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,4DNU1@85009|Propionibacteriales 201174|Actinobacteria V ABC-2 type transporter - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane MMS1_k127_1929709_4 35754.JNYJ01000043_gene4495 1.136e-50 200.0 COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4DCGV@85008|Micromonosporales 201174|Actinobacteria V Transport permease protein - - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane MMS1_k127_1929709_1 134676.ACPL_1455 5.039e-129 419.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DAC8@85008|Micromonosporales 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system nodI - - ko:K09695 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC_tran MMS1_k127_1929709_2 479431.Namu_0594 7.918e-105 349.0 COG0210@1|root,COG0210@2|Bacteria,2IF81@201174|Actinobacteria,4EUVM@85013|Frankiales 201174|Actinobacteria L UvrD-like helicase C-terminal domain - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C MMS1_k127_1935742_17 500153.JOEK01000002_gene125 4.342e-95 340.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF MMS1_k127_1935742_13 35754.JNYJ01000024_gene9066 1.893e-125 432.0 COG4591@1|root,COG4591@2|Bacteria,2I445@201174|Actinobacteria,4DMJ9@85008|Micromonosporales 201174|Actinobacteria M FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX MMS1_k127_1935742_25 1120949.KB903295_gene2300 1.178e-82 280.0 COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4DAEI@85008|Micromonosporales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1935742_20 485913.Krac_3147 2.894e-90 316.0 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 MMS1_k127_1935742_41 1417296.U879_03680 2.235e-40 158.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - ko:K22108 - - - - ko00000,ko03000 - - - TetR_N MMS1_k127_1935742_26 1108045.GORHZ_135_00100 1.383e-82 281.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4GH00@85026|Gordoniaceae 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003,ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,FtsX MMS1_k127_1935742_1 1108045.GORHZ_135_00090 7.132e-247 784.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX MMS1_k127_1935742_23 287.DR97_5735 8.121e-83 289.0 COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,1YKRD@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria FL Metal binding domain of Ada ada GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,HTH_AraC,Methyltransf_1N MMS1_k127_1935742_21 1278308.KB907080_gene2426 1.854e-89 307.0 COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4FN7R@85023|Microbacteriaceae 201174|Actinobacteria GM epimerase dehydratase - - - - - - - - - - - - Epimerase MMS1_k127_1935742_45 1463934.JOCF01000002_gene2975 1.974e-29 120.0 COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 MMS1_k127_1935742_46 1449976.KALB_1975 1.312e-24 115.0 COG0454@1|root,COG0456@2|Bacteria,2HM58@201174|Actinobacteria,4EDJC@85010|Pseudonocardiales 201174|Actinobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_1935742_11 298654.FraEuI1c_4032 5.919e-139 459.0 COG3559@1|root,COG3559@2|Bacteria,2GMSI@201174|Actinobacteria,4EVAJ@85013|Frankiales 201174|Actinobacteria M Exporter of polyketide - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - - MMS1_k127_1935742_12 656024.FsymDg_3866 7.889e-130 422.0 COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4ES7T@85013|Frankiales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 MMS1_k127_1935742_15 345341.KUTG_00500 4.456e-104 366.0 COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,4E0WZ@85010|Pseudonocardiales 201174|Actinobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 MMS1_k127_1935742_34 1043493.BBLU01000014_gene1316 7.933e-59 224.0 COG1131@1|root,COG1131@2|Bacteria,2IH64@201174|Actinobacteria 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1935742_22 1095767.CAHD01000200_gene2345 9.128e-84 287.0 COG1131@1|root,COG1131@2|Bacteria,2ICIF@201174|Actinobacteria,4F24V@85016|Cellulomonadaceae 201174|Actinobacteria V ABC transporter - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1935742_44 457425.XNR_3503 8.692e-37 145.0 COG1309@1|root,COG1309@2|Bacteria,2GP92@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N MMS1_k127_1935742_35 1157637.KB892127_gene3142 2.497e-57 203.0 COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria 201174|Actinobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase MMS1_k127_1935742_37 1089544.KB912942_gene6278 4.357e-50 182.0 COG2207@1|root,COG2207@2|Bacteria,2IFDE@201174|Actinobacteria,4E2S3@85010|Pseudonocardiales 201174|Actinobacteria K PFAM Bacterial regulatory helix-turn-helix proteins, AraC family - - - - - - - - - - - - HTH_18 MMS1_k127_1935742_38 373903.Hore_20800 4.908e-46 170.0 COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3WARC@53433|Halanaerobiales 186801|Clostridia FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam MMS1_k127_1935742_6 1380347.JNII01000005_gene3136 1.54e-189 605.0 COG0160@1|root,COG0160@2|Bacteria,2GIS9@201174|Actinobacteria,4ERVR@85013|Frankiales 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 MMS1_k127_1935742_43 227882.SAV_6015 1.591e-37 155.0 COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria 201174|Actinobacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain cvpA GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944 - - - - - - - - - - Colicin_V,Trypsin_2 MMS1_k127_1935742_7 1382306.JNIM01000001_gene2717 1.999e-165 538.0 COG1012@1|root,COG1012@2|Bacteria,2G83P@200795|Chloroflexi 200795|Chloroflexi C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh MMS1_k127_1935742_33 106370.Francci3_2026 9.874e-65 226.0 COG5514@1|root,COG5514@2|Bacteria,2IS68@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF1794) - - - - - - - - - - - - DUF1794 MMS1_k127_1935742_10 1120936.KB907217_gene3516 5.44e-154 507.0 COG1960@1|root,COG1960@2|Bacteria,2HY6H@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE21 - - ko:K00257 - - R04547,R04592 RC01942 ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_1935742_39 251221.35212914 5.313e-46 183.0 2DB9X@1|root,2Z7ZS@2|Bacteria,1G3ZT@1117|Cyanobacteria 1117|Cyanobacteria S Protein of unknown function (DUF3445) - - 1.14.13.238 ko:K22342 - - - - ko00000,ko01000 - - - DUF3445 MMS1_k127_1935742_42 1440774.Y900_014790 6.161e-39 153.0 COG4420@1|root,COG4420@2|Bacteria,2IHZA@201174|Actinobacteria 201174|Actinobacteria S membrane - - - - - - - - - - - - - MMS1_k127_1935742_4 1463887.KL590014_gene5071 1.197e-219 686.0 COG0451@1|root,COG0451@2|Bacteria,2GJJG@201174|Actinobacteria 201174|Actinobacteria GM Epimerase dehydratase sqdB - 3.13.1.1 ko:K06118 ko00520,ko00561,map00520,map00561 - R05775 RC01469 ko00000,ko00001,ko01000 - - - Epimerase MMS1_k127_1935742_8 1121877.JQKF01000037_gene1807 2.619e-164 542.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia 84992|Acidimicrobiia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS MMS1_k127_1935742_0 1313172.YM304_01730 2.814e-257 831.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,2GM5R@201174|Actinobacteria,4CNNB@84992|Acidimicrobiia 84992|Acidimicrobiia CE Proline dehydrogenase - - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh MMS1_k127_1935742_40 1463917.JODC01000007_gene7468 7.517e-46 175.0 COG3620@1|root,COG3837@1|root,COG3620@2|Bacteria,COG3837@2|Bacteria,2I4X7@201174|Actinobacteria 201174|Actinobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - Cupin_2,HTH_3 MMS1_k127_1935742_2 351607.Acel_1043 3.76e-221 692.0 COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,4ESAX@85013|Frankiales 201174|Actinobacteria E Metallopeptidase family M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 MMS1_k127_1935742_16 351607.Acel_1049 1.989e-96 325.0 COG1172@1|root,COG1172@2|Bacteria,2IAFE@201174|Actinobacteria,4EX5P@85013|Frankiales 201174|Actinobacteria P Branched-chain amino acid transport system / permease component - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 MMS1_k127_1935742_9 351607.Acel_1050 5.167e-161 522.0 COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4ESBS@85013|Frankiales 201174|Actinobacteria P PFAM ABC transporter - - 3.6.3.17 ko:K02056,ko:K10441 ko02010,map02010 M00212,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran MMS1_k127_1935742_31 351607.Acel_1051 1.355e-70 252.0 COG1879@1|root,COG1879@2|Bacteria,2IB5Z@201174|Actinobacteria 201174|Actinobacteria G ABC-type sugar transport system periplasmic component-like protein - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 MMS1_k127_1935742_3 356851.JOAN01000020_gene3974 1.491e-220 694.0 COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,4DAUD@85008|Micromonosporales 201174|Actinobacteria F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 MMS1_k127_1935742_30 1463917.JODC01000007_gene7462 7.205e-71 254.0 COG1028@1|root,COG1028@2|Bacteria,2I6UQ@201174|Actinobacteria 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 MMS1_k127_1935742_36 285535.JOEY01000011_gene6149 1.921e-53 199.0 COG0662@1|root,COG0662@2|Bacteria,2GN99@201174|Actinobacteria 201174|Actinobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 MMS1_k127_1935742_50 551275.KB899546_gene2136 3.688e-10 70.0 COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,43WZY@69657|Hyphomonadaceae 28211|Alphaproteobacteria L exodeoxyribonuclease III xthA2 - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos MMS1_k127_1935742_51 1163617.SCD_n00153 8.663e-10 64.0 COG4627@1|root,COG4627@2|Bacteria,1N8RI@1224|Proteobacteria,2VUSF@28216|Betaproteobacteria 28216|Betaproteobacteria S Stress responsive alpha-beta barrel - - - - - - - - - - - - Dabb MMS1_k127_1935742_24 682795.AciX8_4560 8.597e-83 284.0 COG2013@1|root,COG2013@2|Bacteria,3Y2XF@57723|Acidobacteria,2JIE5@204432|Acidobacteriia 204432|Acidobacteriia S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 MMS1_k127_1935742_18 1279015.KB908457_gene2314 4.712e-95 313.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1Y40Y@135624|Aeromonadales 135624|Aeromonadales O Alkyl hydroperoxide reductase - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA MMS1_k127_1935742_5 913325.N799_02845 3.728e-203 647.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,1RNC7@1236|Gammaproteobacteria,1X4HZ@135614|Xanthomonadales 135614|Xanthomonadales O Alkyl hydroperoxide reductase ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 MMS1_k127_1935742_27 110319.CF8_4142 2.362e-77 273.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition ylbG - - ko:K07497 - - - - ko00000 - - - HTH_29,rve,rve_3 MMS1_k127_1935742_14 1429046.RR21198_4516 4.593e-108 357.0 COG0583@1|root,COG0583@2|Bacteria,2H6E4@201174|Actinobacteria,4FWXR@85025|Nocardiaceae 201174|Actinobacteria K LysR substrate binding domain oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate MMS1_k127_1935742_32 1206735.BAGG01000103_gene4370 1.71e-67 244.0 COG3662@1|root,COG3662@2|Bacteria,2GNTU@201174|Actinobacteria,4FWDY@85025|Nocardiaceae 201174|Actinobacteria S Uncharacterized protein conserved in bacteria (DUF2236) - - - - - - - - - - - - DUF2236 MMS1_k127_1935742_19 298654.FraEuI1c_4086 1.081e-90 315.0 COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4EREF@85013|Frankiales 201174|Actinobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA MMS1_k127_1935742_29 1121946.AUAX01000030_gene1339 1.988e-73 256.0 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4D9TH@85008|Micromonosporales 201174|Actinobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_1935742_48 235985.BBPN01000059_gene7516 4.115e-11 72.0 2C5CZ@1|root,3467W@2|Bacteria,2INJ5@201174|Actinobacteria,2NJ5M@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1935742_49 439235.Dalk_2302 1.511e-10 74.0 COG4870@1|root,COG4870@2|Bacteria,1NC9B@1224|Proteobacteria 1224|Proteobacteria O PFAM Peptidase C1A, papain - - - - - - - - - - - - Peptidase_C1 MMS1_k127_1935742_47 543632.JOJL01000010_gene7235 2.396e-24 119.0 COG0845@1|root,COG0845@2|Bacteria,2H154@201174|Actinobacteria,4DB31@85008|Micromonosporales 201174|Actinobacteria M HlyD family secretion protein - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 MMS1_k127_1935742_28 469371.Tbis_3270 1.488e-74 257.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4DXK6@85010|Pseudonocardiales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_1949858_12 1223523.H340_14036 8.443e-122 394.0 COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria 201174|Actinobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b MMS1_k127_1949858_4 525909.Afer_0633 7.762e-180 573.0 COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia 84992|Acidimicrobiia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE MMS1_k127_1949858_27 525909.Afer_0632 7.744e-78 275.0 COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4CMZX@84992|Acidimicrobiia 84992|Acidimicrobiia M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 MMS1_k127_1949858_14 1313172.YM304_27440 1.414e-115 386.0 COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CMRC@84992|Acidimicrobiia 84992|Acidimicrobiia I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom MMS1_k127_1949858_35 1121877.JQKF01000004_gene1131 1.586e-49 193.0 COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4CN3S@84992|Acidimicrobiia 84992|Acidimicrobiia S Cytidylyltransferase family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 MMS1_k127_1949858_32 1313172.YM304_27460 3.776e-54 198.0 COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4CN2Z@84992|Acidimicrobiia 84992|Acidimicrobiia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF MMS1_k127_1949858_24 1313172.YM304_27470 1.957e-81 279.0 COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CMRF@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase MMS1_k127_1949858_22 1313172.YM304_27480 3.258e-86 292.0 COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4CMXN@84992|Acidimicrobiia 84992|Acidimicrobiia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS MMS1_k127_1949858_16 1229780.BN381_330051 6.394e-99 342.0 COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,3UWBA@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 MMS1_k127_1949858_31 1394178.AWOO02000113_gene5940 3.416e-63 227.0 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4EN22@85012|Streptosporangiales 201174|Actinobacteria L Phage integrase, N-terminal SAM-like domain xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase MMS1_k127_1949858_25 1123023.JIAI01000002_gene5897 2.324e-79 283.0 COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria,4DYX1@85010|Pseudonocardiales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA MMS1_k127_1949858_43 760568.Desku_0438 1.999e-22 102.0 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,262EU@186807|Peptococcaceae 186801|Clostridia J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS MMS1_k127_1949858_42 1123504.JQKD01000024_gene277 3.732e-25 112.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,4AE0B@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like MMS1_k127_1949858_1 1313172.YM304_26780 6.281e-189 599.0 COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4CMTE@84992|Acidimicrobiia 84992|Acidimicrobiia E Class-II DAHP synthetase family - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 MMS1_k127_1949858_41 326427.Cagg_0267 5.12e-30 136.0 COG0406@1|root,COG0406@2|Bacteria,2GAE9@200795|Chloroflexi,375RN@32061|Chloroflexia 32061|Chloroflexia G Belongs to the phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 MMS1_k127_1949858_8 1229780.BN381_10220 1.478e-154 503.0 COG3552@1|root,COG3825@1|root,COG3552@2|Bacteria,COG3825@2|Bacteria,2GNTS@201174|Actinobacteria,3UX9M@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE MMS1_k127_1949858_19 1380356.JNIK01000001_gene2204 1.063e-94 337.0 COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4ETQ9@85013|Frankiales 201174|Actinobacteria S PFAM ATPase associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 MMS1_k127_1949858_11 1121877.JQKF01000001_gene1391 1.124e-130 429.0 COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4CNAA@84992|Acidimicrobiia 84992|Acidimicrobiia E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1949858_20 1229780.BN381_10208 1.074e-93 320.0 COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,3UWHH@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA MMS1_k127_1949858_10 1229780.BN381_10207 1.019e-132 437.0 COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,3UWET@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 MMS1_k127_1949858_3 285514.JNWO01000002_gene5000 1.653e-186 592.0 COG0001@1|root,COG0001@2|Bacteria,2HBVS@201174|Actinobacteria 201174|Actinobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 MMS1_k127_1949858_45 446471.Xcel_3268 4.784e-20 92.0 COG0776@1|root,COG0776@2|Bacteria,2IKQR@201174|Actinobacteria,4F4TM@85017|Promicromonosporaceae 201174|Actinobacteria L bacterial (prokaryotic) histone like domain hup GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding MMS1_k127_1949858_39 525909.Afer_0772 2.505e-32 130.0 COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4CN91@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal L27 protein rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 MMS1_k127_1949858_44 525909.Afer_0771 2.013e-21 96.0 COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4CN9R@84992|Acidimicrobiia 84992|Acidimicrobiia J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p MMS1_k127_1949858_6 1229780.BN381_80102 1.473e-171 554.0 COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,3UW7D@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Ribonuclease E/G family rne - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - IF2_N,RNase_E_G,S1 MMS1_k127_1949858_7 525909.Afer_0769 4.471e-157 523.0 COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CMYJ@84992|Acidimicrobiia 84992|Acidimicrobiia M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase MMS1_k127_1949858_40 525909.Afer_0767 3.637e-31 133.0 COG1792@1|root,COG1792@2|Bacteria,2HGG4@201174|Actinobacteria,4CNDF@84992|Acidimicrobiia 84992|Acidimicrobiia M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC MMS1_k127_1949858_9 1283299.AUKG01000005_gene64 1.964e-149 479.0 COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CP7J@84995|Rubrobacteria 84995|Rubrobacteria D Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl MMS1_k127_1949858_33 1229780.BN381_80093 2.549e-51 186.0 COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,3UWSN@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Nucleoside diphosphate kinase ndk GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - iNJ661.Rv2445c NDK MMS1_k127_1949858_23 1313172.YM304_18330 2.392e-85 298.0 COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CNAR@84992|Acidimicrobiia 84992|Acidimicrobiia H Mur ligase middle domain - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M MMS1_k127_1949858_2 525909.Afer_0763 9.341e-189 597.0 COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4CMS8@84992|Acidimicrobiia 84992|Acidimicrobiia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX MMS1_k127_1949858_17 525909.Afer_0762 4.641e-97 320.0 COG0740@1|root,COG0740@2|Bacteria,2GKNK@201174|Actinobacteria,4CMUY@84992|Acidimicrobiia 84992|Acidimicrobiia O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins - - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease MMS1_k127_1949858_29 1229780.BN381_80089 3.658e-73 263.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,3UWAS@52018|unclassified Actinobacteria (class) 201174|Actinobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N MMS1_k127_1949858_37 479433.Caci_0426 2.266e-46 173.0 COG3871@1|root,COG3871@2|Bacteria,2GWY2@201174|Actinobacteria 201174|Actinobacteria S Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Putative_PNPOx MMS1_k127_1949858_36 1123023.JIAI01000020_gene2090 8.243e-47 179.0 2DMG6@1|root,32RB5@2|Bacteria,2GMQI@201174|Actinobacteria 201174|Actinobacteria S MDMPI C-terminal domain - - - - - - - - - - - - MDMPI_C,MDMPI_N MMS1_k127_1949858_48 1121904.ARBP01000004_gene1151 1.68e-05 47.0 2AH3T@1|root,317D9@2|Bacteria,4P8A6@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - MMS1_k127_1949858_28 326424.FRAAL6835 1.191e-77 268.0 COG1177@1|root,COG1177@2|Bacteria,2GJ6Q@201174|Actinobacteria,4ESYW@85013|Frankiales 201174|Actinobacteria P Binding-protein-dependent transport system inner membrane component potI - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 MMS1_k127_1949858_21 351607.Acel_1282 2.023e-87 302.0 COG1176@1|root,COG1176@2|Bacteria,2GJ5G@201174|Actinobacteria,4ET85@85013|Frankiales 201174|Actinobacteria E Binding-protein-dependent transport system inner membrane component potH - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 MMS1_k127_1949858_15 1417296.U879_09200 2.801e-107 365.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2TSUZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Required for the activity of the bacterial periplasmic transport system of putrescine - - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 MMS1_k127_1949858_13 1408419.JHYG01000010_gene2462 5.264e-117 390.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQQC@204441|Rhodospirillales 204441|Rhodospirillales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 MMS1_k127_1949858_5 1095769.CAHF01000006_gene1762 4.027e-176 565.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria 28216|Betaproteobacteria C Aldehyde dehydrogenase betB - 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1949858_18 313612.L8106_14805 1.592e-95 329.0 COG0531@1|root,COG0531@2|Bacteria,1G9D1@1117|Cyanobacteria,1HDCZ@1150|Oscillatoriales 1117|Cyanobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 MMS1_k127_1949858_46 1123023.JIAI01000003_gene2685 1.795e-17 90.0 COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4E4YJ@85010|Pseudonocardiales 201174|Actinobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS MMS1_k127_1949858_34 446466.Cfla_3493 1.108e-49 194.0 COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4F0G0@85016|Cellulomonadaceae 201174|Actinobacteria S Uncharacterized protein conserved in bacteria (DUF2236) - - - - - - - - - - - - DUF2236 MMS1_k127_1949858_26 1214101.BN159_2510 7.59e-79 269.0 COG1028@1|root,COG1028@2|Bacteria,2I95F@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - ko:K14633 ko01057,ko01130,map01057,map01130 - R09309,R09310 RC02484 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 MMS1_k127_1949858_30 1463885.KL578379_gene6093 4.484e-68 242.0 COG2017@1|root,COG3265@1|root,COG2017@2|Bacteria,COG3265@2|Bacteria,2GJ0H@201174|Actinobacteria 201174|Actinobacteria G Aldose 1-epimerase - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim,SKI MMS1_k127_1949858_38 1229780.BN381_350126 3.915e-38 154.0 COG0496@1|root,COG0496@2|Bacteria,2IFAX@201174|Actinobacteria 201174|Actinobacteria S survival protein SurE surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE MMS1_k127_1949858_47 391625.PPSIR1_15600 6.087e-11 70.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42VTR@68525|delta/epsilon subdivisions,2X5PP@28221|Deltaproteobacteria 28221|Deltaproteobacteria J PFAM Class I peptide chain release factor - - - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 MMS1_k127_1949858_0 1386089.N865_13035 1.544e-195 624.0 COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4FFGS@85021|Intrasporangiaceae 201174|Actinobacteria C methylmalonate-semialdehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_1993037_29 680198.SCAB_35581 1.676e-57 209.0 COG0300@1|root,COG0300@2|Bacteria,2GNPI@201174|Actinobacteria 201174|Actinobacteria S Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) phbB - 1.1.1.333 ko:K16652 - - - - ko00000,ko01000 - - - adh_short MMS1_k127_1993037_5 1120950.KB892742_gene3045 3.342e-149 487.0 COG0277@1|root,COG0277@2|Bacteria,2HZ5X@201174|Actinobacteria,4DNVZ@85009|Propionibacteriales 201174|Actinobacteria C D-arabinono-1,4-lactone oxidase - - 1.1.98.3 ko:K16653 - - - - ko00000,ko01000 - - - ALO,FAD_binding_4 MMS1_k127_1993037_25 1828.JOKB01000058_gene826 2.341e-61 226.0 COG0382@1|root,COG0382@2|Bacteria,2GJ6P@201174|Actinobacteria,4FV0R@85025|Nocardiaceae 201174|Actinobacteria H UbiA prenyltransferase family ubiA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016763,GO:0031224,GO:0031226,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046872,GO:0052636,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.2.45 ko:K14136 - - R10095 RC00005 ko00000,ko01000,ko01006 - - - UbiA MMS1_k127_1993037_30 525909.Afer_0318 3.679e-57 201.0 COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4CN3T@84992|Acidimicrobiia 84992|Acidimicrobiia I B12 binding domain - - 5.4.99.2 ko:K01849 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding MMS1_k127_1993037_2 1313172.YM304_36100 7.795e-165 526.0 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4CMVM@84992|Acidimicrobiia 84992|Acidimicrobiia F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA MMS1_k127_1993037_7 1121877.JQKF01000016_gene138 6.716e-144 469.0 COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CMSK@84992|Acidimicrobiia 84992|Acidimicrobiia C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA MMS1_k127_1993037_32 1229780.BN381_130059 3.323e-54 201.0 COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,3UWRP@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N MMS1_k127_1993037_6 649638.Trad_0076 3.232e-144 474.0 COG0138@1|root,COG0138@2|Bacteria,1WIVC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS MMS1_k127_1993037_15 1229780.BN381_130063 7.186e-97 324.0 COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,3UWCI@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C MMS1_k127_1993037_36 706587.Desti_3420 6.389e-34 143.0 COG0438@1|root,COG0662@1|root,COG0438@2|Bacteria,COG0662@2|Bacteria,1MWSZ@1224|Proteobacteria,42NYZ@68525|delta/epsilon subdivisions,2WK9U@28221|Deltaproteobacteria,2MQ7Y@213462|Syntrophobacterales 28221|Deltaproteobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1,MannoseP_isomer MMS1_k127_1993037_19 1313172.YM304_07250 5.365e-79 272.0 COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4CN4K@84992|Acidimicrobiia 84992|Acidimicrobiia E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR MMS1_k127_1993037_46 1519464.HY22_01095 2.527e-08 58.0 COG0538@1|root,COG0538@2|Bacteria 2|Bacteria C isocitrate dehydrogenase activity icd GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh MMS1_k127_1993037_45 1121877.JQKF01000035_gene1958 2.744e-09 61.0 COG0538@1|root,COG0538@2|Bacteria,2IBM8@201174|Actinobacteria,4CNHG@84992|Acidimicrobiia 84992|Acidimicrobiia C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh MMS1_k127_1993037_10 1121877.JQKF01000035_gene1957 2.814e-134 435.0 COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,4CMPJ@84992|Acidimicrobiia 84992|Acidimicrobiia C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N MMS1_k127_1993037_21 749414.SBI_09365 6.532e-70 246.0 COG2227@1|root,COG2227@2|Bacteria,2GM1S@201174|Actinobacteria 201174|Actinobacteria H Methyltransferase - - - - - - - - - - - - Methyltransf_12,Methyltransf_25 MMS1_k127_1993037_9 1121877.JQKF01000037_gene1807 4.576e-137 476.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia 84992|Acidimicrobiia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS MMS1_k127_1993037_17 1268303.RHODMAR_4433 1.939e-79 276.0 COG2820@1|root,COG2820@2|Bacteria,2IT3V@201174|Actinobacteria,4G51S@85025|Nocardiaceae 201174|Actinobacteria F Phosphorylase superfamily - - - - - - - - - - - - PNP_UDP_1 MMS1_k127_1993037_11 1114959.SZMC14600_01469 2.011e-115 379.0 COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4DXT9@85010|Pseudonocardiales 201174|Actinobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB1 - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 MMS1_k127_1993037_0 1380356.JNIK01000013_gene4321 2.47e-268 837.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4ES69@85013|Frankiales 201174|Actinobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein sdhA GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00278 ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00115,M00149,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C MMS1_k127_1993037_14 479433.Caci_0748 3.517e-99 331.0 2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria 201174|Actinobacteria S membrane - - - - - - - - - - - - - MMS1_k127_1993037_26 1229203.KI301992_gene1965 3.428e-61 222.0 COG0583@1|root,COG0583@2|Bacteria,2HEWP@201174|Actinobacteria,3UWWD@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate MMS1_k127_1993037_34 1211035.CD30_04110 5.62e-49 195.0 29MNG@1|root,308K7@2|Bacteria,1VTU1@1239|Firmicutes,4HTYB@91061|Bacilli 91061|Bacilli - - - - - - - - - - - - - - - MMS1_k127_1993037_33 593907.Celgi_0225 1.268e-53 212.0 COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4F0GU@85016|Cellulomonadaceae 201174|Actinobacteria S MMPL family - - - ko:K06994 - - - - ko00000 - - - MMPL MMS1_k127_1993037_39 525909.Afer_1822 2.112e-22 113.0 2D9MJ@1|root,31D2X@2|Bacteria,2HGQZ@201174|Actinobacteria,4CNT9@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome c oxidase subunit IV - - - - - - - - - - - - Cyt_c_ox_IV MMS1_k127_1993037_1 1121877.JQKF01000003_gene1553 3.708e-244 766.0 COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CMUD@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 MMS1_k127_1993037_27 525909.Afer_1824 2.535e-60 219.0 COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4CN92@84992|Acidimicrobiia 84992|Acidimicrobiia C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM MMS1_k127_1993037_3 570268.ANBB01000058_gene4272 7.111e-157 507.0 COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria,4EJ4K@85012|Streptosporangiales 201174|Actinobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B MMS1_k127_1993037_47 525909.Afer_1819 6.939e-05 52.0 COG1826@1|root,COG1826@2|Bacteria,2HH2I@201174|Actinobacteria,4CP2H@84992|Acidimicrobiia 84992|Acidimicrobiia U mttA/Hcf106 family - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 MMS1_k127_1993037_31 1122239.AULS01000001_gene1981 9.3e-57 205.0 COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4FKUV@85023|Microbacteriaceae 201174|Actinobacteria E AzlC protein - - - - - - - - - - - - AzlC MMS1_k127_1993037_43 935839.JAGJ01000007_gene3139 3.66e-15 87.0 2E45J@1|root,32Z1K@2|Bacteria,2GR89@201174|Actinobacteria,4F4WB@85017|Promicromonosporaceae 201174|Actinobacteria S Branched-chain amino acid transport protein (AzlD) - - - - - - - - - - - - AzlD MMS1_k127_1993037_38 525909.Afer_1989 3.737e-25 115.0 2E8WU@1|root,3336Z@2|Bacteria,2GR5V@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1993037_20 1265313.HRUBRA_00264 2.224e-76 265.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RPSX@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.149,4.2.1.17 ko:K01692,ko:K08299 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R10675 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 MMS1_k127_1993037_28 326424.FRAAL3677 1.424e-57 208.0 COG0586@1|root,COG0586@2|Bacteria,2IA3P@201174|Actinobacteria 201174|Actinobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc MMS1_k127_1993037_18 351607.Acel_0145 2.2e-79 281.0 COG2146@1|root,COG2259@1|root,COG2146@2|Bacteria,COG2259@2|Bacteria,2IKSY@201174|Actinobacteria,4ETHF@85013|Frankiales 201174|Actinobacteria P PFAM Rieske 2Fe-2S - - 1.8.5.2 ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - Rieske MMS1_k127_1993037_22 1229780.BN381_80181 3.376e-68 238.0 COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria 201174|Actinobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain tcrA - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_1993037_24 1268303.RHODMAR_0450 5.326e-64 242.0 COG0642@1|root,COG0642@2|Bacteria,2I2YP@201174|Actinobacteria,4G9JN@85025|Nocardiaceae 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA MMS1_k127_1993037_44 1122182.KB903813_gene2599 2.792e-11 73.0 2DQY4@1|root,339C4@2|Bacteria,2GP83@201174|Actinobacteria,4DB7R@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1993037_42 1415166.NONO_c34270 8.186e-16 84.0 2D6K8@1|root,32TMG@2|Bacteria,2GR9V@201174|Actinobacteria,4G00T@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_1993037_35 44454.NF84_06780 1.429e-34 137.0 COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,238JK@1762|Mycobacteriaceae 201174|Actinobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N MMS1_k127_1993037_23 285535.JOEY01000034_gene9894 8.731e-68 239.0 COG0596@1|root,COG0654@1|root,COG0596@2|Bacteria,COG0654@2|Bacteria,2GJDM@201174|Actinobacteria 201174|Actinobacteria CH Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 MMS1_k127_1993037_12 670487.Ocepr_1815 1.003e-110 369.0 COG3288@1|root,COG3288@2|Bacteria,1WIIT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C NAD NADP transhydrogenase alpha subunit - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N MMS1_k127_1993037_37 760192.Halhy_6317 2.368e-28 117.0 COG3288@1|root,COG3288@2|Bacteria,4NT78@976|Bacteroidetes,1ITS9@117747|Sphingobacteriia 976|Bacteroidetes C 4TM region of pyridine nucleotide transhydrogenase, mitoch pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM MMS1_k127_1993037_4 351607.Acel_2020 8.731e-152 492.0 COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4ERWF@85013|Frankiales 201174|Actinobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB MMS1_k127_1993037_13 1348338.ADILRU_0468 1.778e-100 338.0 COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,2IA5J@201174|Actinobacteria,4FQY1@85023|Microbacteriaceae 201174|Actinobacteria S Virulence protein RhuM family - - - - - - - - - - - - Fic,Virulence_RhuM MMS1_k127_1993037_16 1192034.CAP_8821 4.573e-94 323.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria 1224|Proteobacteria C Aldo Keto reductase - - - - - - - - - - - - Aldo_ket_red MMS1_k127_1993037_41 1123320.KB889669_gene3270 4.283e-19 88.0 COG1141@1|root,COG1141@2|Bacteria 2|Bacteria C electron transfer activity fdxD - - ko:K05337 - - - - ko00000 - - - Fer4_13,Fer4_15 MMS1_k127_1993037_8 710111.FraQA3DRAFT_6279 4.338e-143 475.0 COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4ERZ8@85013|Frankiales 201174|Actinobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c MMS1_k127_2006056_5 1121924.ATWH01000006_gene1979 4.308e-149 484.0 COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4FMU7@85023|Microbacteriaceae 201174|Actinobacteria C 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS1_k127_2006056_1 1121924.ATWH01000006_gene1978 9.473e-185 581.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4FM7V@85023|Microbacteriaceae 201174|Actinobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C MMS1_k127_2006056_2 1121924.ATWH01000006_gene1977 2.154e-157 504.0 COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4FN7V@85023|Microbacteriaceae 201174|Actinobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh MMS1_k127_2006056_23 1207075.PputUW4_01494 1.294e-11 74.0 COG0526@1|root,COG0526@2|Bacteria,1RJUZ@1224|Proteobacteria,1S6Y0@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,LGT,Redoxin MMS1_k127_2006056_18 525909.Afer_1129 3.556e-55 203.0 COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4CNHE@84992|Acidimicrobiia 84992|Acidimicrobiia O Cytochrome C biogenesis protein transmembrane region - - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD MMS1_k127_2006056_4 1273125.Rrhod_2559 2.253e-154 496.0 COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4FUE2@85025|Nocardiaceae 201174|Actinobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C MMS1_k127_2006056_20 396014.BF93_09305 7.472e-48 175.0 COG0346@1|root,COG0346@2|Bacteria,2IMDZ@201174|Actinobacteria 201174|Actinobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase MMS1_k127_2006056_0 1123322.KB904718_gene5093 1.033e-242 758.0 COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria 201174|Actinobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD MMS1_k127_2006056_16 472175.EL18_02622 7.911e-63 227.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,43I2S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Inosine-uridine preferring nucleoside hydrolase rihA GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008655,GO:0009056,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009164,GO:0009165,GO:0009435,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0018130,GO:0019357,GO:0019358,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0034356,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0043094,GO:0043173,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0045437,GO:0046135,GO:0046483,GO:0046496,GO:0046497,GO:0046700,GO:0050263,GO:0051186,GO:0051188,GO:0055086,GO:0070635,GO:0070636,GO:0071704,GO:0072521,GO:0072523,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro MMS1_k127_2006056_19 1122238.AULR01000001_gene2074 6.176e-49 185.0 COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB MMS1_k127_2006056_15 642227.HA49_06620 7.803e-63 228.0 COG0715@1|root,COG0715@2|Bacteria,1QM3B@1224|Proteobacteria,1TJAT@1236|Gammaproteobacteria,4BVGW@82986|Tatumella 1236|Gammaproteobacteria P NMT1/THI5 like - - - - - - - - - - - - NMT1 MMS1_k127_2006056_14 642227.HA49_06615 2.209e-64 239.0 COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,1SZCN@1236|Gammaproteobacteria,4BVK1@82986|Tatumella 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 MMS1_k127_2006056_8 642227.HA49_06610 5.057e-91 305.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,4BVHZ@82986|Tatumella 1236|Gammaproteobacteria P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran MMS1_k127_2006056_11 455632.SGR_6396 5.644e-81 282.0 COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria,419T5@629295|Streptomyces griseus group 201174|Actinobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L MMS1_k127_2006056_17 591167.Sfla_3318 4.269e-57 208.0 COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria 201174|Actinobacteria S PFAM LmbE family protein - - - - - - - - - - - - PIG-L MMS1_k127_2006056_3 1111479.AXAR01000008_gene2292 1.172e-155 507.0 COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,4HE2B@91061|Bacilli 91061|Bacilli P Natural resistance-associated macrophage protein - - - - - - - - - - - - Nramp MMS1_k127_2006056_13 1206731.BAGB01000155_gene5928 1.34e-72 260.0 COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4G6E5@85025|Nocardiaceae 201174|Actinobacteria P MgtE intracellular N domain - - - - - - - - - - - - CBS,MgtE_N,PRC MMS1_k127_2006056_9 1121877.JQKF01000004_gene1090 1.025e-89 306.0 COG2008@1|root,COG2008@2|Bacteria,2GMNV@201174|Actinobacteria,4CNM1@84992|Acidimicrobiia 84992|Acidimicrobiia E Beta-eliminating lyase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase MMS1_k127_2006056_22 1382306.JNIM01000001_gene3890 8.121e-32 129.0 COG2050@1|root,COG2050@2|Bacteria,2G8ZT@200795|Chloroflexi 200795|Chloroflexi Q PFAM thioesterase superfamily protein - - - - - - - - - - - - 4HBT MMS1_k127_2006056_7 525909.Afer_1086 2.722e-103 351.0 COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4CMQV@84992|Acidimicrobiia 84992|Acidimicrobiia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C MMS1_k127_2006056_21 1396418.BATQ01000166_gene1900 3.831e-45 175.0 COG1208@1|root,COG1208@2|Bacteria,46UYH@74201|Verrucomicrobia,2ITZR@203494|Verrucomicrobiae 203494|Verrucomicrobiae JM Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase MMS1_k127_2006056_6 1120949.KB903312_gene625 9.016e-119 405.0 COG5002@1|root,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria,4DGRF@85008|Micromonosporales 201174|Actinobacteria T PAS fold - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,HisKA_3,PAS_4,Response_reg MMS1_k127_2006056_12 351607.Acel_2099 2.315e-80 283.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,2IIRA@201174|Actinobacteria,4ESMY@85013|Frankiales 201174|Actinobacteria T PFAM EAL domain - - - - - - - - - - - - EAL,GAF_2,PAS,PAS_3,Response_reg MMS1_k127_2006056_10 1121877.JQKF01000003_gene1542 8.37e-86 291.0 COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria,4CN0Y@84992|Acidimicrobiia 84992|Acidimicrobiia U ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane MMS1_k127_2006056_24 1206730.BAGA01000025_gene4002 8.652e-11 64.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4FY6T@85025|Nocardiaceae 201174|Actinobacteria V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 MMS1_k127_2179752_18 1122917.KB899668_gene4463 2.261e-27 117.0 COG5628@1|root,COG5628@2|Bacteria,1VAGU@1239|Firmicutes,4HHK0@91061|Bacilli,26QQ8@186822|Paenibacillaceae 91061|Bacilli S Acetyltransferase - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_2179752_6 1121877.JQKF01000003_gene1442 1.368e-159 513.0 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CNIG@84992|Acidimicrobiia 84992|Acidimicrobiia I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_2179752_13 1121877.JQKF01000003_gene1453 7.824e-116 380.0 COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CMVG@84992|Acidimicrobiia 84992|Acidimicrobiia E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 MMS1_k127_2179752_12 1313172.YM304_12990 6.54e-122 400.0 COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4CMRK@84992|Acidimicrobiia 84992|Acidimicrobiia C Isocitrate/isopropylmalate dehydrogenase leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh MMS1_k127_2179752_17 525909.Afer_1535 6.692e-34 150.0 COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4CN6V@84992|Acidimicrobiia 84992|Acidimicrobiia K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N MMS1_k127_2179752_2 1121877.JQKF01000003_gene1450 1.155e-204 651.0 COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4CMTC@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase MMS1_k127_2179752_14 926554.KI912633_gene3829 4.229e-66 237.0 COG0066@1|root,COG0066@2|Bacteria,1WIK6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C MMS1_k127_2179752_3 1370120.AUWR01000008_gene527 4.511e-201 635.0 COG0076@1|root,COG0076@2|Bacteria,2GKIH@201174|Actinobacteria,23CIC@1762|Mycobacteriaceae 201174|Actinobacteria E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.11,4.1.1.25,4.1.2.27 ko:K01634,ko:K18933 ko00350,ko00410,ko00600,ko00680,ko00770,ko01100,ko01110,ko04071,map00350,map00410,map00600,map00680,map00770,map01100,map01110,map04071 M00100 R00489,R00736,R02464,R06516 RC00264,RC00299,RC00721,RC01266 ko00000,ko00001,ko00002,ko01000 - - - Pyridoxal_deC MMS1_k127_2179752_10 1370120.AUWR01000008_gene528 1.064e-146 482.0 COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,23FHH@1762|Mycobacteriaceae 201174|Actinobacteria G FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.17,2.7.1.215,2.7.1.53 ko:K00854,ko:K00862,ko:K00880 ko00040,ko00053,ko01100,map00040,map00053,map01100 M00014 R01639,R01901,R07127,R11536 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N MMS1_k127_2179752_9 1077974.GOEFS_044_00220 6.478e-152 490.0 COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4GAXB@85026|Gordoniaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain fadE2_1 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_2179752_22 585531.HMPREF0063_11439 8.539e-05 53.0 COG3170@1|root,COG3170@2|Bacteria 2|Bacteria NU translation initiation factor activity - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - - MMS1_k127_2179752_1 1229780.BN381_450030 3.088e-237 745.0 COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,3UW8G@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer MMS1_k127_2179752_11 926550.CLDAP_06320 4.225e-144 464.0 COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi 200795|Chloroflexi C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red MMS1_k127_2179752_4 1121877.JQKF01000003_gene1446 4.197e-183 587.0 COG0111@1|root,COG0111@2|Bacteria,2GJGA@201174|Actinobacteria,4CMQA@84992|Acidimicrobiia 84992|Acidimicrobiia EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C MMS1_k127_2179752_5 28042.GU90_05565 1.065e-171 548.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4DY66@85010|Pseudonocardiales 201174|Actinobacteria E PFAM Aminotransferase class I and II aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 MMS1_k127_2179752_8 471852.Tcur_0832 1.251e-152 494.0 COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4EID9@85012|Streptosporangiales 201174|Actinobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 MMS1_k127_2179752_15 1071679.BG57_20620 6.406e-60 213.0 COG1335@1|root,COG1335@2|Bacteria,1RBHB@1224|Proteobacteria,2VNM8@28216|Betaproteobacteria,1K0F6@119060|Burkholderiaceae 28216|Betaproteobacteria Q isochorismatase hydrolase - - - - - - - - - - - - Isochorismatase MMS1_k127_2179752_7 1313172.YM304_11450 2.936e-153 490.0 COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4CMV2@84992|Acidimicrobiia 84992|Acidimicrobiia H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN MMS1_k127_2179752_16 525909.Afer_1546 2.936e-42 162.0 COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CN3W@84992|Acidimicrobiia 84992|Acidimicrobiia E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C MMS1_k127_2179752_0 1121877.JQKF01000003_gene1461 2.418e-245 769.0 COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CMWQ@84992|Acidimicrobiia 84992|Acidimicrobiia H Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N MMS1_k127_2179752_19 357808.RoseRS_1743 7.478e-21 102.0 COG4932@1|root,COG4932@2|Bacteria,2G7MG@200795|Chloroflexi,376NW@32061|Chloroflexia 32061|Chloroflexia M PFAM Cna B domain protein - - - - - - - - - - - - - MMS1_k127_2183438_0 935948.KE386495_gene2256 9.105e-12 70.0 COG3405@1|root,COG3405@2|Bacteria,1VBUA@1239|Firmicutes 1239|Firmicutes G Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - - - - - - - - - - - MMS1_k127_2184866_0 768671.ThimaDRAFT_1929 2.243e-168 544.0 COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1WYPQ@135613|Chromatiales 135613|Chromatiales L PFAM Integrase catalytic - - - - - - - - - - - - rve MMS1_k127_2184866_1 351348.Maqu_2661 7.103e-71 251.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,4679W@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP MMS1_k127_2184866_2 1123065.ATWL01000007_gene3162 6.827e-21 95.0 COG3576@1|root,COG3576@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Putative_PNPOx MMS1_k127_2195928_1 888050.HMPREF9004_0875 1.398e-145 467.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4D5D0@85005|Actinomycetales 201174|Actinobacteria C Pyridine nucleotide-disulfide oxidoreductase preT - - - - - - - - - - - Fer4,Fer4_20,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 MMS1_k127_2195928_0 1157638.KB892165_gene3609 2.523e-193 624.0 COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria 201174|Actinobacteria NU type II secretion system protein E pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N MMS1_k127_2195928_2 935866.JAER01000047_gene3922 9.8e-116 392.0 COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4DPSR@85009|Propionibacteriales 201174|Actinobacteria NU Type II secretion system (T2SS), protein F - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF MMS1_k127_2195928_3 398578.Daci_5804 5.589e-06 59.0 COG1361@1|root,COG3055@1|root,COG3468@1|root,COG4625@1|root,COG1361@2|Bacteria,COG3055@2|Bacteria,COG3468@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria 28216|Betaproteobacteria MU TIGRFAM outer membrane autotransporter barrel domain protein - - - - - - - - - - - - Autotransporter,He_PIG,TIG MMS1_k127_2195928_4 1122609.AUGT01000001_gene2840 0.0006148 46.0 COG2165@1|root,COG2165@2|Bacteria,2I4YC@201174|Actinobacteria,4DWH0@85009|Propionibacteriales 201174|Actinobacteria NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl MMS1_k127_2237174_9 1229780.BN381_80328 2.623e-89 307.0 COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,3UWHI@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Peptidase family M28 - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 MMS1_k127_2237174_8 1120950.KB892784_gene202 2.803e-108 356.0 COG2171@1|root,COG2171@2|Bacteria,2IBDI@201174|Actinobacteria 201174|Actinobacteria E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 MMS1_k127_2237174_6 1313172.YM304_26990 1.732e-130 428.0 COG0436@1|root,COG0436@2|Bacteria,2H440@201174|Actinobacteria,4CMXW@84992|Acidimicrobiia 84992|Acidimicrobiia E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 MMS1_k127_2237174_5 1121877.JQKF01000004_gene1100 2.607e-132 439.0 COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CMWR@84992|Acidimicrobiia 84992|Acidimicrobiia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 MMS1_k127_2237174_19 1444770.AF72_09915 5.871e-32 137.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1X4YZ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase MMS1_k127_2237174_10 1313172.YM304_27020 2.421e-80 278.0 COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4CN5X@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT MMS1_k127_2237174_4 1229780.BN381_80317 1.149e-154 501.0 COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,3UW97@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 MMS1_k127_2237174_17 1246995.AFR_36760 2.916e-49 187.0 COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria,4DBJZ@85008|Micromonosporales 201174|Actinobacteria S EamA-like transporter family - - - ko:K11939 - - - - ko00000,ko02000 2.A.7.3.6 - - EamA MMS1_k127_2237174_15 1121877.JQKF01000004_gene1113 3.338e-53 200.0 COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4CNCE@84992|Acidimicrobiia 84992|Acidimicrobiia E GHMP kinases N terminal domain - - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N MMS1_k127_2237174_16 1121877.JQKF01000007_gene979 2.019e-49 192.0 COG1686@1|root,COG1686@2|Bacteria,2GM2X@201174|Actinobacteria,4CNMD@84992|Acidimicrobiia 84992|Acidimicrobiia M D-alanyl-D-alanine carboxypeptidase - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 MMS1_k127_2237174_2 1313172.YM304_16440 8.198e-180 589.0 COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4CMSW@84992|Acidimicrobiia 84992|Acidimicrobiia D Ftsk_gamma - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma MMS1_k127_2237174_22 391937.NA2_13100 2.6e-26 118.0 COG2375@1|root,COG2375@2|Bacteria,1R4TD@1224|Proteobacteria,2U6G4@28211|Alphaproteobacteria,43JGW@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Siderophore-interacting protein - - - - - - - - - - - - FAD_binding_9,SIP MMS1_k127_2237174_3 1313172.YM304_16400 4.408e-170 554.0 COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4CMS5@84992|Acidimicrobiia 84992|Acidimicrobiia S Zn-dependent metallo-hydrolase RNA specificity domain - - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,RMMBL MMS1_k127_2237174_11 1121877.JQKF01000004_gene1117 5.727e-77 275.0 COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4CN0H@84992|Acidimicrobiia 84992|Acidimicrobiia E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS MMS1_k127_2237174_14 644283.Micau_1485 3.733e-59 213.0 COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4D8IW@85008|Micromonosporales 201174|Actinobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2773c DapB_C,DapB_N MMS1_k127_2237174_18 525909.Afer_1023 2.578e-46 192.0 COG5617@1|root,COG5617@2|Bacteria 2|Bacteria M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - MMS1_k127_2237174_0 1313172.YM304_16080 3.471e-292 921.0 COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CMSF@84992|Acidimicrobiia 84992|Acidimicrobiia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,S1 MMS1_k127_2237174_20 767029.HMPREF9154_1282 7.629e-32 127.0 COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4DS16@85009|Propionibacteriales 201174|Actinobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 MMS1_k127_2237174_12 1120936.KB907220_gene2030 3.385e-67 240.0 COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4EHXD@85012|Streptosporangiales 201174|Actinobacteria H Riboflavin kinase ribF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase MMS1_k127_2237174_13 1151122.AQYD01000006_gene2462 2.486e-59 216.0 COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4FKEW@85023|Microbacteriaceae 201174|Actinobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C,TruB_C_2,TruB_N MMS1_k127_2237174_23 266117.Rxyl_1413 2.35e-13 79.0 COG0858@1|root,COG0858@2|Bacteria,2HPFC@201174|Actinobacteria,4CQTS@84995|Rubrobacteria 84995|Rubrobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA MMS1_k127_2237174_1 525909.Afer_0638 4.166e-292 921.0 COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CMS2@84992|Acidimicrobiia 84992|Acidimicrobiia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N MMS1_k127_2237174_24 697281.Mahau_1034 0.0004584 47.0 COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,42H84@68295|Thermoanaerobacterales 186801|Clostridia K Protein of unknown function (DUF448) ylxR - - ko:K07742 - - - - ko00000 - - - DUF448 MMS1_k127_2237174_7 1121877.JQKF01000004_gene1125 2.74e-125 414.0 COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia 84992|Acidimicrobiia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 MMS1_k127_2237174_21 1229780.BN381_330068 2.084e-31 131.0 COG0779@1|root,COG0779@2|Bacteria,2I9BT@201174|Actinobacteria,3UWYK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C MMS1_k127_2259498_36 1242864.D187_003199 3.065e-37 142.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,42QCZ@68525|delta/epsilon subdivisions,2WJA7@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q pfam abc - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2259498_4 519989.ECTPHS_03592 3.004e-230 741.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX MMS1_k127_2259498_6 519989.ECTPHS_03587 1.932e-203 657.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS MMS1_k127_2259498_14 1229780.BN381_50120 9.03e-113 378.0 COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,3UWUC@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Histidyl-tRNA synthetase hisS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His MMS1_k127_2259498_7 1121877.JQKF01000045_gene1208 5.812e-201 660.0 COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CMU8@84992|Acidimicrobiia 84992|Acidimicrobiia J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon MMS1_k127_2259498_11 1313172.YM304_26410 4.356e-128 424.0 COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CMYY@84992|Acidimicrobiia 84992|Acidimicrobiia O MgsA AAA+ ATPase C terminal - - - ko:K07478 - - - - ko00000 - - - AAA_assoc_2,MgsA_C,RuvB_N MMS1_k127_2259498_2 525909.Afer_0951 1.786e-244 781.0 COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4CMTK@84992|Acidimicrobiia 84992|Acidimicrobiia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD MMS1_k127_2259498_48 477641.MODMU_3338 4.331e-17 86.0 COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4ET3K@85013|Frankiales 201174|Actinobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA ruvX GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX MMS1_k127_2259498_31 525909.Afer_0953 6.245e-50 192.0 COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4CN7T@84992|Acidimicrobiia 84992|Acidimicrobiia S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG MMS1_k127_2259498_41 395963.Bind_3572 3.62e-30 135.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,3N9N9@45404|Beijerinckiaceae 28211|Alphaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N MMS1_k127_2259498_18 1121877.JQKF01000002_gene1765 1.407e-86 299.0 COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CN2U@84992|Acidimicrobiia 84992|Acidimicrobiia D Cell cycle protein - - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE MMS1_k127_2259498_53 929704.Myrod_2368 0.0003158 49.0 COG1259@1|root,COG1259@2|Bacteria,4NGSW@976|Bacteroidetes,1HXCB@117743|Flavobacteriia,47I4T@76831|Myroides 976|Bacteroidetes S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR MMS1_k127_2259498_16 1313172.YM304_02140 1.198e-104 355.0 COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4CMWK@84992|Acidimicrobiia 84992|Acidimicrobiia D Cell cycle protein - - - - - - - - - - - - FTSW_RODA_SPOVE MMS1_k127_2259498_5 1380356.JNIK01000016_gene3788 2.114e-209 671.0 COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4ERTG@85013|Frankiales 201174|Actinobacteria P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N MMS1_k127_2259498_19 656024.FsymDg_0692 3.431e-77 274.0 COG0392@1|root,COG0392@2|Bacteria,2GZ8W@201174|Actinobacteria 201174|Actinobacteria S Lysylphosphatidylglycerol synthase TM region - - 2.3.2.3 ko:K07027,ko:K14205,ko:K20468 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504,ko02000 2.A.1.3.37,4.D.2,4.D.2.4.1 - - LPG_synthase_TM MMS1_k127_2259498_23 188626.HMPREF0321_0839 3.164e-69 242.0 COG1215@1|root,COG1215@2|Bacteria,2I2PK@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 MMS1_k127_2259498_34 675635.Psed_5577 4.07e-49 194.0 COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4DY9A@85010|Pseudonocardiales 201174|Actinobacteria HQ chorismate binding enzyme menF - 5.4.4.2 ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind MMS1_k127_2259498_22 1313172.YM304_24030 1.122e-70 245.0 COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CN6D@84992|Acidimicrobiia 84992|Acidimicrobiia H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran MMS1_k127_2259498_30 1313172.YM304_24090 7.533e-51 184.0 COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria,4CN24@84992|Acidimicrobiia 84992|Acidimicrobiia I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas MMS1_k127_2259498_27 525909.Afer_0836 4.203e-64 227.0 COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4CMZV@84992|Acidimicrobiia 84992|Acidimicrobiia S VIT family - - - - - - - - - - - - VIT1 MMS1_k127_2259498_39 390989.JOEG01000009_gene1055 4.648e-34 150.0 COG0477@1|root,COG2814@2|Bacteria,2IA1T@201174|Actinobacteria,4DBN9@85008|Micromonosporales 201174|Actinobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 MMS1_k127_2259498_33 469371.Tbis_0451 3.001e-49 186.0 COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4DY2M@85010|Pseudonocardiales 201174|Actinobacteria K Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol mshD GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701 2.3.1.189 ko:K15520 - - - - ko00000,ko01000 - - - Acetyltransf_1 MMS1_k127_2259498_50 1229780.BN381_80382 8.876e-16 86.0 COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,3UX0E@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C MMS1_k127_2259498_37 1380347.JNII01000006_gene1386 3.686e-35 154.0 COG3064@1|root,COG3064@2|Bacteria,2IPMP@201174|Actinobacteria,4EWGV@85013|Frankiales 201174|Actinobacteria M calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - MMS1_k127_2259498_43 1313172.YM304_24300 1.341e-25 114.0 COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4CN2A@84992|Acidimicrobiia 84992|Acidimicrobiia E N-(5'phosphoribosyl)anthranilate (PRA) isomerase trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI MMS1_k127_2259498_13 525909.Afer_1089 1.766e-121 406.0 COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4CMVV@84992|Acidimicrobiia 84992|Acidimicrobiia IQ Beta-ketoacyl synthase, C-terminal domain - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt MMS1_k127_2259498_44 1121877.JQKF01000021_gene2200 7.564e-23 99.0 COG0236@1|root,COG0236@2|Bacteria,2HGA0@201174|Actinobacteria,4CN8U@84992|Acidimicrobiia 84992|Acidimicrobiia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding MMS1_k127_2259498_25 743718.Isova_1380 2.505e-66 237.0 COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4F3S8@85017|Promicromonosporaceae 201174|Actinobacteria IQ KR domain fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 MMS1_k127_2259498_29 525909.Afer_1085 4.489e-54 207.0 COG0331@1|root,COG0511@1|root,COG0331@2|Bacteria,COG0511@2|Bacteria,2GME0@201174|Actinobacteria,4CMPZ@84992|Acidimicrobiia 84992|Acidimicrobiia I Acyl transferase domain - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 MMS1_k127_2259498_42 1172186.KB911468_gene930 3.346e-26 119.0 COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,2354F@1762|Mycobacteriaceae 201174|Actinobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_2259498_46 1463936.JOJI01000026_gene3342 1.145e-17 94.0 COG4948@1|root,COG4948@2|Bacteria 2|Bacteria M carboxylic acid catabolic process menC GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N MMS1_k127_2259498_35 1133850.SHJG_3485 6.744e-49 181.0 COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria 201174|Actinobacteria T response regulator pdtaR GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944 - ko:K22010 - M00839 - - ko00000,ko00002,ko02022 - - - ANTAR,Response_reg MMS1_k127_2259498_3 1229780.BN381_80407 9.229e-236 757.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,3UWEE@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 MMS1_k127_2259498_8 1313172.YM304_21410 9.943e-190 602.0 COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CMW4@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal protein S1-like RNA-binding domain rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 MMS1_k127_2259498_45 1206733.BAGC01000035_gene3774 9.75e-21 106.0 29YQR@1|root,30KKI@2|Bacteria,2HNUR@201174|Actinobacteria,4G5YB@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2259498_21 1123023.JIAI01000030_gene4422 2.677e-71 249.0 COG0510@1|root,COG0510@2|Bacteria,2GMFN@201174|Actinobacteria,4EFCQ@85010|Pseudonocardiales 201174|Actinobacteria M Phosphotransferase enzyme family - - - - - - - - - - - - APH MMS1_k127_2259498_12 1146883.BLASA_2833 1.556e-122 404.0 COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4EUCP@85013|Frankiales 201174|Actinobacteria P Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS1_k127_2259498_17 1120936.KB907209_gene1792 1.087e-103 359.0 COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria 201174|Actinobacteria EP Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,BPD_transp_1,oligo_HPY MMS1_k127_2259498_24 2002.JOEQ01000005_gene3502 1.904e-68 242.0 COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4EFFP@85012|Streptosporangiales 201174|Actinobacteria P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031,ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,BPD_transp_1,oligo_HPY MMS1_k127_2259498_26 1122611.KB903967_gene5142 2.128e-65 235.0 COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4EM9K@85012|Streptosporangiales 201174|Actinobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS1_k127_2259498_38 1121372.AULK01000001_gene2017 3.627e-34 138.0 COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4FNR9@85023|Microbacteriaceae 201174|Actinobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE,GrpB MMS1_k127_2259498_1 1313172.YM304_21490 1.215e-252 796.0 COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4CMWE@84992|Acidimicrobiia 84992|Acidimicrobiia L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB MMS1_k127_2259498_0 1043493.BBLU01000001_gene1016 0.0 1204.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran MMS1_k127_2259498_9 1229780.BN381_50096 3.196e-148 491.0 COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,3UWEG@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N MMS1_k127_2259498_20 1121877.JQKF01000028_gene2132 7.365e-73 257.0 COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4CMXB@84992|Acidimicrobiia 84992|Acidimicrobiia S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 MMS1_k127_2259498_32 1206726.BAFV01000041_gene3098 2.121e-49 191.0 COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4FUHS@85025|Nocardiaceae 201174|Actinobacteria S Required for morphogenesis under gluconeogenic growth conditions - - - - - - - - - - - - UPF0052 MMS1_k127_2259498_10 1121877.JQKF01000028_gene2134 5.106e-133 433.0 COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4CMQP@84992|Acidimicrobiia 84992|Acidimicrobiia G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N MMS1_k127_2259498_15 1229780.BN381_80402 2.769e-111 380.0 COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,3UWA2@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Phosphoglycerate kinase pgk GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK MMS1_k127_2259498_28 1105029.HMPREF1137_0216 3.781e-61 224.0 COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria,4D3F0@85005|Actinomycetales 201174|Actinobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM MMS1_k127_2259498_47 1121877.JQKF01000028_gene2137 4.201e-17 83.0 COG1314@1|root,COG1314@2|Bacteria,2HGDT@201174|Actinobacteria,4CNCC@84992|Acidimicrobiia 84992|Acidimicrobiia U Preprotein translocase SecG subunit - - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG MMS1_k127_2259498_49 1408452.JAGZ01000001_gene3844 7.605e-16 91.0 COG0747@1|root,COG0747@2|Bacteria,2GJ9N@201174|Actinobacteria,233EQ@1762|Mycobacteriaceae 201174|Actinobacteria E extracellular solute-binding oppA GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043295,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072341,GO:1900750,GO:1901681,GO:1904680 - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS1_k127_2259498_52 1300350.DSW25_04925 7.985e-13 81.0 COG1961@1|root,COG1961@2|Bacteria,1MW94@1224|Proteobacteria,2TUFN@28211|Alphaproteobacteria,3ZX24@60136|Sulfitobacter 28211|Alphaproteobacteria L Resolvase, N terminal domain - GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - - - - - - - - - - HTH_23,HTH_7,HTH_8,Resolvase MMS1_k127_2259498_51 1122622.ATWJ01000014_gene394 2.509e-15 86.0 2AYN7@1|root,31QSQ@2|Bacteria,2IQ18@201174|Actinobacteria,4FJ6C@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2267516_39 1116232.AHBF01000151_gene1189 8.44e-114 377.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria 201174|Actinobacteria E Glutamate synthase preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 MMS1_k127_2267516_16 345341.KUTG_00476 3.744e-160 510.0 COG1013@1|root,COG1013@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor porB - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C MMS1_k127_2267516_17 1123487.KB892840_gene75 6.352e-160 518.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,2KVEF@206389|Rhodocyclales 206389|Rhodocyclales C Pyruvate:ferredoxin oxidoreductase core domain II padG - 1.2.1.58 ko:K18355 ko00360,map00360 - R02450 RC00004,RC02860 br01601,ko00000,ko00001,ko01000 - - - PFOR_II,POR_N MMS1_k127_2267516_69 870187.Thini_2405 9.362e-65 227.0 COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,1S7UK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR MMS1_k127_2267516_80 1906.SFRA_19020 1.014e-44 166.0 COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria 201174|Actinobacteria CO Belongs to the thioredoxin family trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 - - - Thioredoxin MMS1_k127_2267516_67 326424.FRAAL3351 2.406e-65 238.0 COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,4EVH1@85013|Frankiales 201174|Actinobacteria E serine O-acetyltransferase cysE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N MMS1_k127_2267516_19 243233.MCA1022 1.863e-147 473.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales 135618|Methylococcales H Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS1_k127_2267516_92 351607.Acel_0232 4.415e-37 151.0 COG3511@1|root,COG3511@2|Bacteria,2II4P@201174|Actinobacteria,4ET75@85013|Frankiales 201174|Actinobacteria M Phosphoesterase family - - 3.1.3.64 ko:K21302 ko00562,ko01100,ko05152,map00562,map01100,map05152 - - - ko00000,ko00001,ko01000 - - - Phosphoesterase MMS1_k127_2267516_35 365528.KB891263_gene641 1.558e-123 409.0 COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,4ERPB@85013|Frankiales 201174|Actinobacteria M cyclopropane-fatty-acyl-phospholipid synthase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS MMS1_k127_2267516_28 1380390.JIAT01000011_gene2397 1.209e-132 441.0 COG4097@1|root,COG4097@2|Bacteria,2GKWX@201174|Actinobacteria,4CRXT@84995|Rubrobacteria 84995|Rubrobacteria P FAD-binding domain - - - - - - - - - - - - FAD_binding_8,Ferric_reduct,NAD_binding_1 MMS1_k127_2267516_107 1298863.AUEP01000013_gene4098 1.657e-09 69.0 COG3976@1|root,COG3976@2|Bacteria,2GTTI@201174|Actinobacteria,4DS7S@85009|Propionibacteriales 201174|Actinobacteria S FMN_bind - - - - - - - - - - - - FMN_bind MMS1_k127_2267516_88 1121877.JQKF01000008_gene638 4.159e-40 165.0 COG1477@1|root,COG1477@2|Bacteria,2GN6F@201174|Actinobacteria,4CNY8@84992|Acidimicrobiia 84992|Acidimicrobiia H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE MMS1_k127_2267516_98 2045.KR76_05065 8.641e-29 123.0 COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4DQPG@85009|Propionibacteriales 201174|Actinobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC MMS1_k127_2267516_86 1380354.JIAN01000005_gene2068 1.008e-40 154.0 COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4F1FY@85016|Cellulomonadaceae 201174|Actinobacteria H TOBE domain - - - - - - - - - - - - HTH_17,MerR,TOBE MMS1_k127_2267516_11 1304275.C41B8_09126 3.262e-176 576.0 COG0555@1|root,COG3842@1|root,COG0555@2|Bacteria,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,1RXZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily - - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE_2 MMS1_k127_2267516_70 1121952.ATXT01000013_gene2226 5.594e-60 225.0 COG0725@1|root,COG0725@2|Bacteria 2|Bacteria P tungstate binding - - - ko:K15495 ko02010,map02010 M00423 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.5 - - SBP_bac_11 MMS1_k127_2267516_104 401526.TcarDRAFT_0535 4.478e-14 81.0 COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,4H59P@909932|Negativicutes 909932|Negativicutes H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 MMS1_k127_2267516_96 1313172.YM304_09020 3.338e-33 133.0 COG0314@1|root,COG0314@2|Bacteria,2HG21@201174|Actinobacteria,4CN80@84992|Acidimicrobiia 84992|Acidimicrobiia H MoaE protein - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE MMS1_k127_2267516_51 1313172.YM304_11030 4.063e-93 321.0 COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CMP8@84992|Acidimicrobiia 84992|Acidimicrobiia H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N MMS1_k127_2267516_101 1313172.YM304_37920 1.126e-16 83.0 COG1977@1|root,COG1977@2|Bacteria 2|Bacteria H Mo-molybdopterin cofactor metabolic process moaD - 2.8.1.12 ko:K03636,ko:K21142 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE,ThiS MMS1_k127_2267516_84 1313172.YM304_20590 1.159e-42 165.0 COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4CN1Q@84992|Acidimicrobiia 84992|Acidimicrobiia H Probable molybdopterin binding domain - - - - - - - - - - - - MoCF_biosynth MMS1_k127_2267516_45 1229780.BN381_90064 1.799e-104 350.0 COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,3UX2T@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Molybdenum Cofactor Synthesis C moaA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM MMS1_k127_2267516_74 272568.GDI3212 7.219e-55 205.0 COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,2JQ12@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 MMS1_k127_2267516_71 1116369.KB890024_gene435 9.343e-60 224.0 COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2TUGD@28211|Alphaproteobacteria,43HNM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 MMS1_k127_2267516_30 311402.Avi_5419 1.783e-129 432.0 COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria,4BDQH@82115|Rhizobiaceae 28211|Alphaproteobacteria S ATPases associated with a variety of cellular activities - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran MMS1_k127_2267516_89 1294142.CINTURNW_0833 7.898e-40 164.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,36WQV@31979|Clostridiaceae 186801|Clostridia S ABC-type transport system, periplasmic component surface lipoprotein - - - ko:K07335 - - - - ko00000 - - - Bmp MMS1_k127_2267516_94 766499.C357_19301 1.665e-34 141.0 COG1846@1|root,COG1846@2|Bacteria,1N0MG@1224|Proteobacteria,2UDDI@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional MA20_26570 - - ko:K22296 - - - - ko00000,ko03000 - - - MarR,MarR_2 MMS1_k127_2267516_64 438753.AZC_2797 2.331e-67 239.0 COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,2TTG1@28211|Alphaproteobacteria,3F13Y@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - - ko:K09740 - - - - ko00000 - - - ApbE MMS1_k127_2267516_8 1197906.CAJQ02000043_gene2002 2.645e-197 634.0 COG2816@1|root,COG2816@2|Bacteria,1MV1F@1224|Proteobacteria,2TTRT@28211|Alphaproteobacteria,3JSNJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L COG1180 Pyruvate-formate lyase-activating enzyme MA20_26535 - 1.3.7.1 ko:K20449 ko00760,ko01120,map00760,map01120 - R03164 RC02422 ko00000,ko00001,ko01000 - - - - MMS1_k127_2267516_1 1040983.AXAE01000014_gene5051 1.053e-311 980.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,43H6S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 MMS1_k127_2267516_73 981384.AEYW01000018_gene3234 2.442e-57 209.0 COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TSYF@28211|Alphaproteobacteria,4ND3M@97050|Ruegeria 28211|Alphaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 MMS1_k127_2267516_27 1254432.SCE1572_37920 5.767e-133 439.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,42MVJ@68525|delta/epsilon subdivisions,2WKM4@28221|Deltaproteobacteria,2YUP4@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_2267516_37 1123288.SOV_1c06630 4.851e-115 383.0 COG0402@1|root,COG0402@2|Bacteria,1TTHY@1239|Firmicutes 1239|Firmicutes F Amidohydrolase family - - 3.5.2.18 ko:K15358 ko00760,ko01120,map00760,map01120 - R07984 RC01933 ko00000,ko00001,ko01000 - - - Amidohydro_1 MMS1_k127_2267516_65 1125863.JAFN01000001_gene2459 8.582e-67 233.0 28I63@1|root,2Z897@2|Bacteria,1N3VY@1224|Proteobacteria,42RHM@68525|delta/epsilon subdivisions,2WNSJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Amino acid synthesis - - - - - - - - - - - - AA_synth MMS1_k127_2267516_99 525909.Afer_1564 2.171e-26 124.0 COG2068@1|root,COG2068@2|Bacteria,2HG9S@201174|Actinobacteria,4CN88@84992|Acidimicrobiia 84992|Acidimicrobiia S MobA-like NTP transferase domain - - 1.1.1.328,2.7.7.76 ko:K07141,ko:K19190 ko00760,ko00790,ko01120,map00760,map00790,map01120 - R10131,R10132,R11582 RC03053 ko00000,ko00001,ko01000 - - - NTP_transf_3 MMS1_k127_2267516_97 1306174.JODP01000006_gene3139 4.243e-32 128.0 COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria 201174|Actinobacteria O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI MMS1_k127_2267516_63 42256.RradSPS_2620 9.868e-68 240.0 COG1975@1|root,COG1975@2|Bacteria,2GIZS@201174|Actinobacteria,4CQ5H@84995|Rubrobacteria 84995|Rubrobacteria O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI MMS1_k127_2267516_76 675635.Psed_1504 1.271e-51 196.0 COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4E2XZ@85010|Pseudonocardiales 201174|Actinobacteria Q PFAM Isochorismatase pncA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase MMS1_k127_2267516_5 1449346.JQMO01000003_gene3931 7.164e-243 773.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,2M0RC@2063|Kitasatospora 201174|Actinobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N MMS1_k127_2267516_21 1313172.YM304_26900 1.005e-145 469.0 COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria 201174|Actinobacteria C Ferredoxin oxidoreductase korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C MMS1_k127_2267516_75 1206731.BAGB01000047_gene5231 1.641e-53 192.0 COG0599@1|root,COG0599@2|Bacteria,2IM8G@201174|Actinobacteria,4G8MT@85025|Nocardiaceae 201174|Actinobacteria S Carboxymuconolactone decarboxylase family pcaC - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD MMS1_k127_2267516_0 1957.JODX01000017_gene1855 0.0 1414.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria 201174|Actinobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 MMS1_k127_2267516_4 1476876.JOJO01000049_gene695 1.218e-245 769.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB MMS1_k127_2267516_78 710686.Mycsm_01498 6.4e-47 175.0 COG1905@1|root,COG1905@2|Bacteria,2IM0C@201174|Actinobacteria 201174|Actinobacteria C PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit - - 1.6.5.3 ko:K00127,ko:K00334 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx MMS1_k127_2267516_46 1121924.ATWH01000003_gene1402 4.195e-103 343.0 COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4FMB9@85023|Microbacteriaceae 201174|Actinobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ MMS1_k127_2267516_68 1121952.ATXT01000014_gene1445 5.52e-65 228.0 arCOG07343@1|root,326WF@2|Bacteria,2GZK1@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2267516_14 436229.JOEH01000002_gene3424 5.076e-163 525.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,2NIEJ@228398|Streptacidiphilus 201174|Actinobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C MMS1_k127_2267516_54 1123023.JIAI01000001_gene7771 2.258e-89 306.0 COG1071@1|root,COG1071@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor - - 1.2.4.1,1.2.4.4 ko:K00161,ko:K11381,ko:K21416 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh MMS1_k127_2267516_7 1209984.BN978_01513 2.316e-217 680.0 COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria,23EWF@1762|Mycobacteriaceae 201174|Actinobacteria E Metallopeptidase family M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 MMS1_k127_2267516_40 436229.JOEH01000002_gene3427 2.22e-112 371.0 COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,2NHIR@228398|Streptacidiphilus 201174|Actinobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 MMS1_k127_2267516_50 1121877.JQKF01000006_gene950 1.044e-98 330.0 COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4CN2Y@84992|Acidimicrobiia 84992|Acidimicrobiia E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS1_k127_2267516_49 1121877.JQKF01000006_gene949 1.411e-99 332.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4CMZ8@84992|Acidimicrobiia 201174|Actinobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 MMS1_k127_2267516_53 485913.Krac_9354 8.94e-91 319.0 COG4177@1|root,COG4177@2|Bacteria,2G8KF@200795|Chloroflexi 200795|Chloroflexi E transport system permease - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS1_k127_2267516_44 485913.Krac_9355 1.337e-104 347.0 COG0559@1|root,COG0559@2|Bacteria,2G93P@200795|Chloroflexi 200795|Chloroflexi E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 MMS1_k127_2267516_32 1449353.JQMQ01000004_gene5925 6.52e-125 413.0 COG0683@1|root,COG0683@2|Bacteria,2HERM@201174|Actinobacteria,2NFKM@228398|Streptacidiphilus 201174|Actinobacteria E Receptor family ligand binding region - - - - - - - - - - - - Peripla_BP_6 MMS1_k127_2267516_41 351607.Acel_0890 1.43e-110 369.0 COG1073@1|root,COG1073@2|Bacteria,2GNST@201174|Actinobacteria,4EU2M@85013|Frankiales 201174|Actinobacteria S Belongs to the UPF0255 family - - - - - - - - - - - - DUF1100,Hydrolase_4 MMS1_k127_2267516_34 1121877.JQKF01000001_gene1338 5.644e-124 411.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4CMW0@84992|Acidimicrobiia 84992|Acidimicrobiia C e3 binding domain - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS1_k127_2267516_111 1242864.D187_009722 5.074e-05 55.0 COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42N4M@68525|delta/epsilon subdivisions,2X9VB@28221|Deltaproteobacteria,2Z105@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_2267516_106 1121877.JQKF01000007_gene972 4.267e-12 76.0 28SZC@1|root,2ZF8S@2|Bacteria,2HBRK@201174|Actinobacteria,4CNUV@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2267516_77 1229781.C272_15422 2.12e-50 184.0 COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4F99U@85019|Brevibacteriaceae 201174|Actinobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - iNJ661.Rv3628 Pyrophosphatase MMS1_k127_2267516_38 211114.JOEF01000001_gene7299 7.361e-114 380.0 COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4DYZJ@85010|Pseudonocardiales 201174|Actinobacteria I Dehydrogenase fadB2 - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N MMS1_k127_2267516_48 1283287.KB822575_gene535 7.726e-102 338.0 COG0788@1|root,COG0788@2|Bacteria,2GM0G@201174|Actinobacteria,4DP82@85009|Propionibacteriales 201174|Actinobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,ACT_6,Formyl_trans_N MMS1_k127_2267516_26 68260.JOAY01000026_gene4354 2.045e-133 436.0 COG3844@1|root,COG3844@2|Bacteria,2GMJQ@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 MMS1_k127_2267516_56 1236902.ANAS01000038_gene3061 9.493e-87 294.0 COG1028@1|root,COG1028@2|Bacteria,2GM3I@201174|Actinobacteria,4EPAZ@85012|Streptosporangiales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short,adh_short_C2 MMS1_k127_2267516_2 1121877.JQKF01000012_gene332 3.744e-309 954.0 COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4CNI9@84992|Acidimicrobiia 84992|Acidimicrobiia S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn MMS1_k127_2267516_33 1120948.KB903225_gene5588 1.168e-124 415.0 COG0477@1|root,COG0477@2|Bacteria,2I31V@201174|Actinobacteria,4E1WF@85010|Pseudonocardiales 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2267516_62 471852.Tcur_4191 4.464e-72 276.0 COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4EH2C@85012|Streptosporangiales 201174|Actinobacteria S ABC transporter substrate-binding protein PnrA-like - - - ko:K07335 - - - - ko00000 - - - Bmp MMS1_k127_2267516_9 1123320.KB889688_gene398 2.732e-195 621.0 COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria 201174|Actinobacteria S ABC transporter yufO - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran MMS1_k127_2267516_55 390989.JOEG01000023_gene5746 1.092e-87 306.0 COG4603@1|root,COG4603@2|Bacteria,2GKAZ@201174|Actinobacteria,4D9JU@85008|Micromonosporales 201174|Actinobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 MMS1_k127_2267516_61 1096756.ATKN01000004_gene179 3.102e-80 297.0 COG1079@1|root,COG1079@2|Bacteria,2GKMB@201174|Actinobacteria,1W80R@1268|Micrococcaceae 201174|Actinobacteria S Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 MMS1_k127_2267516_90 35754.JNYJ01000005_gene5580 7.551e-38 154.0 COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria,4D954@85008|Micromonosporales 201174|Actinobacteria G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB MMS1_k127_2267516_58 875328.JDM601_1169 1.319e-83 288.0 COG2313@1|root,COG2313@2|Bacteria,2GK19@201174|Actinobacteria,23CEX@1762|Mycobacteriaceae 201174|Actinobacteria Q Indigoidine synthase A like protein psuG - 4.2.1.70 ko:K16329 ko00240,map00240 - R01055 RC00432,RC00433 ko00000,ko00001,ko01000 - - - Indigoidine_A MMS1_k127_2267516_91 1211815.CBYP010000045_gene813 7.836e-38 148.0 COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria,4ET21@85013|Frankiales 201174|Actinobacteria F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1,dCMP_cyt_deam_2 MMS1_k127_2267516_13 33876.JNXY01000026_gene3512 4.748e-166 535.0 COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4D8U4@85008|Micromonosporales 201174|Actinobacteria F phosphorylase deoA GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C MMS1_k127_2267516_20 1157637.KB892113_gene4862 4.424e-146 470.0 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iNJ661.Rv3313c A_deaminase MMS1_k127_2267516_29 1283287.KB822578_gene2290 9.588e-130 434.0 COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4DMY7@85009|Propionibacteriales 201174|Actinobacteria G Phosphoglucomutase/phosphomannomutase, C-terminal domain pmmB - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV MMS1_k127_2267516_59 1449353.JQMQ01000005_gene3818 1.643e-83 289.0 COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,2NG4K@228398|Streptacidiphilus 201174|Actinobacteria F Phosphorylase superfamily punA GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 MMS1_k127_2267516_60 1440053.JOEI01000008_gene6527 2.179e-83 289.0 COG1012@1|root,COG1012@2|Bacteria,2GKSN@201174|Actinobacteria 201174|Actinobacteria C Aldehyde dehydrogenase - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_2267516_6 479433.Caci_0798 2.579e-227 719.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_2267516_31 479435.Kfla_1386 5.798e-125 407.0 COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DNUJ@85009|Propionibacteriales 201174|Actinobacteria F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC MMS1_k127_2267516_105 105420.BBPO01000086_gene4922 7.269e-13 76.0 COG3291@1|root,COG3291@2|Bacteria,2HHTF@201174|Actinobacteria,2NHQJ@228398|Streptacidiphilus 201174|Actinobacteria S PKD domain - - - - - - - - - - - - PKD,Phosphoesterase,fn3 MMS1_k127_2267516_81 1463854.JOHT01000006_gene6581 1.086e-44 175.0 COG1898@1|root,COG1898@2|Bacteria,2GMW4@201174|Actinobacteria 201174|Actinobacteria M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rmlC - 5.1.3.13,5.1.3.27 ko:K01790,ko:K13312 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793,M00794 R06437,R06514 RC01519,RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom MMS1_k127_2267516_24 1449976.KALB_7929 5.15e-135 436.0 COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4E023@85010|Pseudonocardiales 201174|Actinobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd MMS1_k127_2267516_42 743718.Isova_2396 1.224e-106 357.0 COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4F352@85017|Promicromonosporaceae 201174|Actinobacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase MMS1_k127_2267516_79 649831.L083_1728 6.81e-46 172.0 COG1268@1|root,COG1268@2|Bacteria,2GJ53@201174|Actinobacteria,4DJ8M@85008|Micromonosporales 201174|Actinobacteria S BioY family bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY MMS1_k127_2267516_83 269800.Tfu_1544 2.297e-43 167.0 COG1024@1|root,COG1024@2|Bacteria,2I9VC@201174|Actinobacteria,4EMYN@85012|Streptosporangiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 MMS1_k127_2267516_18 711393.AYRX01000013_gene3408 1.313e-149 489.0 COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria 201174|Actinobacteria E Belongs to the peptidase M24B family pepPI - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 MMS1_k127_2267516_15 1122611.KB903940_gene1817 3.606e-161 516.0 COG2124@1|root,COG2124@2|Bacteria,2HMMY@201174|Actinobacteria,4ENAU@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 MMS1_k127_2267516_102 1394178.AWOO02000014_gene7680 3.574e-15 80.0 COG1141@1|root,COG1141@2|Bacteria,2I1X8@201174|Actinobacteria,4EQ1G@85012|Streptosporangiales 201174|Actinobacteria C 4Fe-4S single cluster domain of Ferredoxin I - - - - - - - - - - - - Fer4_15 MMS1_k127_2267516_47 1205910.B005_1819 8.633e-103 347.0 COG0560@1|root,COG3830@1|root,COG0560@2|Bacteria,COG3830@2|Bacteria,2GJDH@201174|Actinobacteria,4EFXE@85012|Streptosporangiales 201174|Actinobacteria E ACT domain serB GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0004722,GO:0005488,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016597,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0031406,GO:0036094,GO:0036211,GO:0040007,GO:0042578,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - iNJ661.Rv3042c ACT_6,HAD MMS1_k127_2267516_43 68260.JOAY01000031_gene3145 2.861e-105 360.0 COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,MFS_3 MMS1_k127_2267516_66 469371.Tbis_1486 2.376e-65 229.0 COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4DZBZ@85010|Pseudonocardiales 201174|Actinobacteria S Bacterial transferase hexapeptide (six repeats) - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 MMS1_k127_2267516_85 1155714.KB891987_gene2286 5.73e-41 163.0 COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria 201174|Actinobacteria V transport, permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane MMS1_k127_2267516_52 1122611.KB903953_gene5713 3.804e-91 309.0 COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4EI49@85012|Streptosporangiales 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2267516_12 525909.Afer_0653 5.133e-173 550.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4CMRW@84992|Acidimicrobiia 84992|Acidimicrobiia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA MMS1_k127_2267516_22 1068978.AMETH_1911 2.151e-141 461.0 COG1680@1|root,COG1680@2|Bacteria,2H2SY@201174|Actinobacteria,4DXGA@85010|Pseudonocardiales 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase MMS1_k127_2267516_25 1469245.JFBG01000054_gene2100 6.368e-134 439.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1T236@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth MMS1_k127_2267516_95 1229780.BN381_80304 2.227e-33 136.0 COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,3UWWX@52018|unclassified Actinobacteria (class) 201174|Actinobacteria I CDP-alcohol phosphatidyltransferase pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf MMS1_k127_2267516_23 1313172.YM304_16500 4.661e-138 451.0 COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CMWG@84992|Acidimicrobiia 2|Bacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine rimO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 MMS1_k127_2267516_100 1121363.KB902201_gene1815 2.057e-25 112.0 COG0406@1|root,COG1051@1|root,COG0406@2|Bacteria,COG1051@2|Bacteria,2I2N2@201174|Actinobacteria,22JRA@1653|Corynebacteriaceae 201174|Actinobacteria FG Belongs to the Nudix hydrolase family mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - His_Phos_1,NUDIX MMS1_k127_2267516_87 440512.C211_16520 1.207e-40 160.0 COG0730@1|root,COG0730@2|Bacteria,1R712@1224|Proteobacteria,1S6UI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE MMS1_k127_2267516_82 543632.JOJL01000027_gene2801 1.154e-43 164.0 2DMC7@1|root,32J0V@2|Bacteria,2I81N@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF4395) - - - - - - - - - - - - DUF4395 MMS1_k127_2267516_57 351607.Acel_1461 1.318e-83 305.0 COG2247@1|root,COG4934@1|root,COG2247@2|Bacteria,COG4934@2|Bacteria,2HEYG@201174|Actinobacteria,4EVX7@85013|Frankiales 2|Bacteria M Pro-kumamolisin, activation domain - - - ko:K08677 - - - - ko00000,ko01002 - - - CW_binding_2,Peptidase_S8,Pro-kuma_activ,fn3 MMS1_k127_2267516_93 521098.Aaci_0976 1.065e-35 157.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity celD GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005488,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0006073,GO:0006464,GO:0006508,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009100,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015929,GO:0016052,GO:0016231,GO:0016787,GO:0016798,GO:0019538,GO:0030246,GO:0033946,GO:0036211,GO:0043170,GO:0043412,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044403,GO:0044419,GO:0051704,GO:0052736,GO:0071554,GO:0071704,GO:0085030,GO:0140096,GO:1901135,GO:1901564,GO:1901575,GO:2000895,GO:2000899 1.1.3.9,2.1.1.72,3.1.3.5,3.1.4.46,3.2.1.1,3.2.1.14,3.2.1.156,3.2.1.35,3.2.1.4,3.2.1.50,3.2.1.73,3.2.1.78,3.2.1.8,3.2.1.91,3.2.1.96,3.2.1.97,3.4.11.10,3.4.21.50,3.4.24.25,3.4.24.3,4.2.2.20,4.2.2.21,4.2.2.3,5.2.1.8 ko:K00571,ko:K01081,ko:K01126,ko:K01176,ko:K01179,ko:K01181,ko:K01183,ko:K01197,ko:K01205,ko:K01216,ko:K01218,ko:K01227,ko:K01337,ko:K01387,ko:K01729,ko:K03768,ko:K03924,ko:K03933,ko:K04618,ko:K05994,ko:K07004,ko:K07282,ko:K08604,ko:K08738,ko:K08961,ko:K09607,ko:K13276,ko:K13735,ko:K14645,ko:K15531,ko:K17624,ko:K19668,ko:K20276,ko:K21449 ko00051,ko00052,ko00230,ko00240,ko00500,ko00511,ko00520,ko00531,ko00564,ko00760,ko00920,ko01100,ko01110,ko01120,ko01524,ko02020,ko02024,ko04115,ko04142,ko04210,ko04214,ko04215,ko04932,ko04973,ko05010,ko05012,ko05014,ko05016,ko05100,ko05110,ko05111,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00051,map00052,map00230,map00240,map00500,map00511,map00520,map00531,map00564,map00760,map00920,map01100,map01110,map01120,map01524,map02020,map02024,map04115,map04142,map04210,map04214,map04215,map04932,map04973,map05010,map05012,map05014,map05016,map05100,map05110,map05111,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00076,M00077,M00078,M00595 R00183,R00511,R00963,R01030,R01098,R01126,R01206,R01227,R01332,R01470,R01569,R01664,R01968,R02088,R02102,R02108,R02112,R02323,R02334,R02719,R02886,R03346,R03706,R06200,R07816,R07824,R07825,R10151,R10905,R11262,R11307,R11308 RC00017,RC00194,RC00425,RC00467,RC00799,RC03151,RC03152 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko01002,ko02000,ko02042,ko02048,ko03110,ko04147 1.B.40.2,3.D.4.6 AA10,CBM73,GH101,GH13,GH18,GH26,GH5,GH6,GH8,GH9 - CHU_C,GSDH,PKD MMS1_k127_2267516_3 1380390.JIAT01000009_gene522 1.64e-257 806.0 COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CP9R@84995|Rubrobacteria 84995|Rubrobacteria T Elongation factor G C-terminus - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 MMS1_k127_2267516_110 1298863.AUEP01000005_gene2436 7.91e-06 55.0 COG2318@1|root,COG2318@2|Bacteria,2II1I@201174|Actinobacteria,4DR3V@85009|Propionibacteriales 201174|Actinobacteria S Protein of unknown function (DUF664) - - - - - - - - - - - - DUF664,DinB_2 MMS1_k127_2267516_103 1298863.AUEP01000002_gene1554 2.394e-14 81.0 COG1309@1|root,COG1309@2|Bacteria,2IEU9@201174|Actinobacteria,4DW3K@85009|Propionibacteriales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_2267516_36 1146883.BLASA_0113 6.019e-123 411.0 COG2267@1|root,COG2267@2|Bacteria,2I3AI@201174|Actinobacteria,4EU9C@85013|Frankiales 201174|Actinobacteria I Alpha/beta hydrolase family dhmA - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 MMS1_k127_2267516_109 1206744.BAGL01000032_gene22 4.574e-07 60.0 2CRBS@1|root,32SNS@2|Bacteria,2IQS0@201174|Actinobacteria,4G1NR@85025|Nocardiaceae 201174|Actinobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 MMS1_k127_2267516_10 298654.FraEuI1c_3065 1.641e-184 599.0 COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria 201174|Actinobacteria P Pfam Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase MMS1_k127_2267516_72 1463936.JOJI01000008_gene5678 5.378e-58 210.0 COG0300@1|root,COG0300@2|Bacteria,2I6YN@201174|Actinobacteria 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short MMS1_k127_2284532_45 640132.Srot_0703 1.058e-54 201.0 COG3576@1|root,COG3576@2|Bacteria,2GKCF@201174|Actinobacteria 201174|Actinobacteria S pyridoxamine 5-phosphate - - - - - - - - - - - - Putative_PNPOx MMS1_k127_2284532_71 479431.Namu_0022 6.841e-32 128.0 COG1977@1|root,COG1977@2|Bacteria,2IQJJ@201174|Actinobacteria,4EWX0@85013|Frankiales 201174|Actinobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - - - - - - - - - - ThiS MMS1_k127_2284532_3 2002.JOEQ01000031_gene1649 8.873e-212 665.0 COG4447@1|root,COG4447@2|Bacteria,2GM8J@201174|Actinobacteria,4EH3D@85012|Streptosporangiales 201174|Actinobacteria S cellulose binding - - - - - - - - - - - - BNR MMS1_k127_2284532_25 1298863.AUEP01000003_gene2972 2.852e-75 260.0 COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4DT5Q@85009|Propionibacteriales 201174|Actinobacteria S Oxidoreductase molybdopterin binding domain - - - - - - - - - - - - Oxidored_molyb MMS1_k127_2284532_59 1298863.AUEP01000003_gene2971 9.485e-38 152.0 COG2864@1|root,COG2864@2|Bacteria,2GNYK@201174|Actinobacteria,4DUJD@85009|Propionibacteriales 201174|Actinobacteria C Prokaryotic cytochrome b561 - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB MMS1_k127_2284532_10 1206743.BAGM01000196_gene967 1.142e-156 505.0 COG3177@1|root,COG3177@2|Bacteria,2GN3K@201174|Actinobacteria,4FZGG@85025|Nocardiaceae 201174|Actinobacteria S Fic/DOC family - - - - - - - - - - - - Fic,Fic_N MMS1_k127_2284532_60 866774.HMPREF9248_0448 2.156e-37 154.0 COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CUYP@84998|Coriobacteriia 84998|Coriobacteriia S Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 MMS1_k127_2284532_75 1313172.YM304_41120 4.738e-25 110.0 COG0745@1|root,COG0745@2|Bacteria 1313172.YM304_41120|- T phosphorelay signal transduction system - - - - - - - - - - - - - MMS1_k127_2284532_81 1229780.BN381_100117 1.971e-18 89.0 2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,3UWYX@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whiB3 - - ko:K18955 - - - - ko00000,ko03000 - - - Whib MMS1_k127_2284532_73 1449976.KALB_1558 1.623e-30 129.0 COG4243@1|root,COG4243@2|Bacteria,2IPJ2@201174|Actinobacteria,4E4W5@85010|Pseudonocardiales 201174|Actinobacteria S VKc - - - - - - - - - - - - VKOR MMS1_k127_2284532_49 105425.BBPL01000059_gene5044 6.016e-49 186.0 arCOG03842@1|root,30WW9@2|Bacteria,2IDJ1@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF929) - - - - - - - - - - - - DUF929 MMS1_k127_2284532_51 225937.HP15_3568 1.57e-45 174.0 COG0491@1|root,COG0494@1|root,COG0491@2|Bacteria,COG0494@2|Bacteria,1MVC3@1224|Proteobacteria,1S25T@1236|Gammaproteobacteria,46AP6@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes blaB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,NUDIX MMS1_k127_2284532_24 446470.Snas_6085 3.845e-76 267.0 COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria 201174|Actinobacteria T response regulator tcsR3 - - - - - - - - - - - GerE,Response_reg MMS1_k127_2284532_27 644548.SCNU_03162 2.462e-70 254.0 COG4585@1|root,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria,4GC9N@85026|Gordoniaceae 201174|Actinobacteria T PspC domain tcsS3 - - - - - - - - - - - HATPase_c,HATPase_c_2,PspC MMS1_k127_2284532_85 40571.JOEA01000013_gene1377 2.487e-09 68.0 COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4E1BF@85010|Pseudonocardiales 201174|Actinobacteria KT PFAM PspC domain pspC - - - - - - - - - - - DUF2154,PspC MMS1_k127_2284532_20 1313172.YM304_38460 7.853e-83 287.0 COG0489@1|root,COG2151@1|root,COG0489@2|Bacteria,COG2151@2|Bacteria,2H1YI@201174|Actinobacteria,4CNPI@84992|Acidimicrobiia 84992|Acidimicrobiia F Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA MMS1_k127_2284532_61 525909.Afer_0240 8.003e-37 142.0 COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4CN53@84992|Acidimicrobiia 84992|Acidimicrobiia S Iron-sulphur cluster biosynthesis erpA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn MMS1_k127_2284532_79 873513.HMPREF6485_1269 8.32e-22 98.0 COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,2FT8J@200643|Bacteroidia 976|Bacteroidetes J endoribonuclease L-PSP ridA - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP MMS1_k127_2284532_67 500153.JOEK01000014_gene5685 5.8e-35 140.0 COG0645@1|root,COG0645@2|Bacteria,2IM2M@201174|Actinobacteria 201174|Actinobacteria S AAA domain - - - - - - - - - - - - AAA_33 MMS1_k127_2284532_42 1313172.YM304_38350 1.118e-57 216.0 COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CN27@84992|Acidimicrobiia 84992|Acidimicrobiia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C MMS1_k127_2284532_8 1313172.YM304_38340 2.439e-160 516.0 COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4CMV7@84992|Acidimicrobiia 84992|Acidimicrobiia E glutamine synthetase - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N MMS1_k127_2284532_6 106370.Francci3_3143 1.251e-165 528.0 COG0174@1|root,COG0174@2|Bacteria,2GKU9@201174|Actinobacteria 201174|Actinobacteria E glutamine synthetase glnII - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N MMS1_k127_2284532_9 1313172.YM304_38270 3.895e-158 517.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4CMPV@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase MMS1_k127_2284532_13 1313172.YM304_03760 2.275e-149 478.0 COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4CMST@84992|Acidimicrobiia 84992|Acidimicrobiia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 MMS1_k127_2284532_69 521674.Plim_4225 6.627e-34 134.0 COG0681@1|root,COG0681@2|Bacteria,2J0ZP@203682|Planctomycetes 203682|Planctomycetes U Belongs to the peptidase S26 family - - - - - - - - - - - - - MMS1_k127_2284532_29 1121877.JQKF01000018_gene2565 1.749e-69 243.0 COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4CN1K@84992|Acidimicrobiia 84992|Acidimicrobiia E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD MMS1_k127_2284532_50 525909.Afer_1924 3.532e-48 184.0 COG0569@1|root,COG0569@2|Bacteria,2HH1S@201174|Actinobacteria,4CP21@84992|Acidimicrobiia 84992|Acidimicrobiia C TrkA-C domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N MMS1_k127_2284532_47 525909.Afer_1923 2.792e-53 198.0 COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria 201174|Actinobacteria P PFAM TrkA-N domain protein ceoB - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N MMS1_k127_2284532_5 1123320.KB889574_gene5634 1.879e-195 636.0 COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria 201174|Actinobacteria E amino acid - - - - - - - - - - - - AA_permease_2 MMS1_k127_2284532_1 1229780.BN381_150139 1.219e-281 893.0 COG0550@1|root,COG0550@2|Bacteria,2GJU7@201174|Actinobacteria,3UW7H@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt MMS1_k127_2284532_53 1313172.YM304_03470 3.636e-43 167.0 COG0125@1|root,COG0125@2|Bacteria,2HF93@201174|Actinobacteria,4CNDK@84992|Acidimicrobiia 84992|Acidimicrobiia F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin MMS1_k127_2284532_65 1121933.AUHH01000042_gene3577 1.576e-35 150.0 COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4DNVR@85009|Propionibacteriales 201174|Actinobacteria L DNA polymerase III holB GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C MMS1_k127_2284532_41 1122182.KB903834_gene6181 3.982e-58 219.0 COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4D91Y@85008|Micromonosporales 201174|Actinobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M MMS1_k127_2284532_19 1306174.JODP01000006_gene3121 1.435e-86 301.0 COG1365@1|root,COG1365@2|Bacteria,2GR2T@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2284532_68 1108045.GORHZ_102_00180 1.597e-34 146.0 COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,4GBYK@85026|Gordoniaceae 201174|Actinobacteria S Multi-copper polyphenol oxidoreductase laccase yfiH GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 MMS1_k127_2284532_62 223184.AS25_09740 1.496e-36 142.0 COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,1W9KW@1268|Micrococcaceae 201174|Actinobacteria P Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR MMS1_k127_2284532_58 1074451.CRL705_96 7.451e-39 162.0 COG0803@1|root,COG0803@2|Bacteria,1V110@1239|Firmicutes,4HZ7G@91061|Bacilli,3FBJR@33958|Lactobacillaceae 91061|Bacilli P Belongs to the bacterial solute-binding protein 9 family psaA - - ko:K02077,ko:K11707 ko02010,map02010 M00244,M00319 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15 - - ZnuA MMS1_k127_2284532_34 485913.Krac_1450 7.459e-62 224.0 COG1121@1|root,COG1121@2|Bacteria,2G5WQ@200795|Chloroflexi 200795|Chloroflexi P PFAM ABC transporter related - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran MMS1_k127_2284532_40 456442.Mboo_1167 2.598e-59 223.0 COG1108@1|root,arCOG01006@2157|Archaea,2XTNB@28890|Euryarchaeota 28890|Euryarchaeota P COG1108 ABC-type Mn2 Zn2 transport systems permease components znuB1 - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - iAF692.Mbar_A0996 ABC-3 MMS1_k127_2284532_31 1313172.YM304_37680 1.178e-64 231.0 COG0037@1|root,COG0037@2|Bacteria,2GJR4@201174|Actinobacteria,4CN76@84992|Acidimicrobiia 84992|Acidimicrobiia J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3 MMS1_k127_2284532_37 1121877.JQKF01000035_gene1977 1.593e-60 214.0 COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,4CNRA@84992|Acidimicrobiia 84992|Acidimicrobiia F Phosphoribosyl transferase domain - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran MMS1_k127_2284532_26 1229780.BN381_110024 7.687e-71 252.0 COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,3UWJV@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3609c GTP_cyclohydroI MMS1_k127_2284532_39 1341646.CBMO010000140_gene2539 5.696e-60 219.0 COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,233ZD@1762|Mycobacteriaceae 201174|Actinobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - HPPK,Pterin_bind MMS1_k127_2284532_64 1229780.BN381_110026 2.865e-36 143.0 2F3QB@1|root,33WH4@2|Bacteria,2H50W@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2284532_80 1229780.BN381_110027 3.54e-21 97.0 COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,3UWX7@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB GO:0008150,GO:0040007 1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8 ko:K01633,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00840 R03503,R03504,R11037,R11073 RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB MMS1_k127_2284532_72 1229780.BN381_110028 7.655e-31 136.0 COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,3UWU2@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK MMS1_k127_2284532_52 1313172.YM304_36920 2.875e-45 173.0 COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria 201174|Actinobacteria S Oxidoreductase - - - - - - - - - - - - DUF2520,Rossmann-like MMS1_k127_2284532_44 1122175.ATXU01000005_gene2528 7.734e-57 214.0 COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4FN3G@85023|Microbacteriaceae 201174|Actinobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase MMS1_k127_2284532_18 1229780.BN381_110048 2.761e-87 296.0 COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,3UWI1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase MMS1_k127_2284532_12 1229780.BN381_110049 6.682e-151 491.0 COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,3UW8P@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon MMS1_k127_2284532_22 1313172.YM304_03920 9.589e-80 276.0 COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4CMZ7@84992|Acidimicrobiia 84992|Acidimicrobiia H Polyprenyl synthetase - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt MMS1_k127_2284532_0 1385521.N803_11445 0.0 1137.0 COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4FES5@85021|Intrasporangiaceae 201174|Actinobacteria O ATP-dependent Clp protease clpC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR MMS1_k127_2284532_17 1380370.JIBA01000019_gene1085 5.922e-96 329.0 COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4FF4M@85021|Intrasporangiaceae 201174|Actinobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C MMS1_k127_2284532_38 1121877.JQKF01000035_gene1966 5.688e-60 211.0 COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CN2D@84992|Acidimicrobiia 84992|Acidimicrobiia K CarD-like/TRCF domain - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF MMS1_k127_2284532_57 1121385.AQXW01000004_gene3211 7.205e-39 154.0 COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,1ZWXI@145357|Dermacoccaceae 201174|Actinobacteria I Belongs to the IspD TarI cytidylyltransferase family. IspD subfamily ispD GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD MMS1_k127_2284532_54 765912.Thimo_1326 5.575e-43 162.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1WY23@135613|Chromatiales 135613|Chromatiales I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB MMS1_k127_2284532_36 1229780.BN381_150089 3.634e-61 223.0 COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,3UWDZ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind MMS1_k127_2284532_43 1680.BADO_1520 1.699e-57 224.0 COG2247@1|root,COG3209@1|root,COG2247@2|Bacteria,COG3209@2|Bacteria,2IE09@201174|Actinobacteria,4D2V6@85004|Bifidobacteriales 201174|Actinobacteria M Cysteine-rich secretory protein family - - - - - - - - - - - - Big_2,CAP,Flg_new MMS1_k127_2284532_91 33898.JRHJ01000002_gene1494 0.0008163 48.0 COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria 201174|Actinobacteria K cell envelope-related transcriptional attenuator - - - - - - - - - - - - LytR_C,LytR_cpsA_psr MMS1_k127_2284532_46 1068978.AMETH_0945 4.373e-54 202.0 COG0463@1|root,COG0463@2|Bacteria,2I2NK@201174|Actinobacteria,4E09C@85010|Pseudonocardiales 201174|Actinobacteria M PFAM Glycosyl transferase family 2 gpgS GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006011,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009225,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0034641,GO:0040007,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046983,GO:0055086,GO:0071704,GO:1901135,GO:1901360 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - Glycos_transf_2 MMS1_k127_2284532_15 2074.JNYD01000006_gene1705 4.374e-146 482.0 COG0498@1|root,COG0498@2|Bacteria,2GNM0@201174|Actinobacteria,4DYA8@85010|Pseudonocardiales 201174|Actinobacteria E Threonine synthase thrC3 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS1_k127_2284532_76 932678.THERU_07785 8.516e-25 110.0 COG1977@1|root,COG1977@2|Bacteria,2G563@200783|Aquificae 200783|Aquificae H TIGRFAM MoaD family protein - - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS MMS1_k127_2284532_2 525909.Afer_1846 2.964e-272 846.0 COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CNG0@84992|Acidimicrobiia 84992|Acidimicrobiia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 MMS1_k127_2284532_23 1229780.BN381_150097 1.486e-76 262.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity ywfI - - ko:K00435 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R11522 RC00884 ko00000,ko00001,ko01000 - - - Chlor_dismutase MMS1_k127_2284532_21 1313172.YM304_05030 8.203e-81 274.0 COG1051@1|root,COG1051@2|Bacteria,2HG6C@201174|Actinobacteria,4CN3B@84992|Acidimicrobiia 84992|Acidimicrobiia F Hydrolase of X-linked nucleoside diphosphate N terminal - - - - - - - - - - - - NUDIX,Nudix_N MMS1_k127_2284532_66 1246995.AFR_14165 2.543e-35 141.0 COG0454@1|root,COG0456@2|Bacteria,2IMVD@201174|Actinobacteria,4DE5M@85008|Micromonosporales 201174|Actinobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_2284532_77 395963.Bind_2584 1.256e-23 104.0 2E5T0@1|root,330HC@2|Bacteria,1ND4Z@1224|Proteobacteria,2VGUI@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS1_k127_2284532_32 1123276.KB893262_gene4077 5.477e-64 228.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23,Methyltransf_25,Methyltransf_31 MMS1_k127_2284532_78 1479623.JHEL01000015_gene728 2.835e-22 100.0 2EMVE@1|root,33FHN@2|Bacteria,2I5BN@201174|Actinobacteria,4FQ15@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2284532_16 1283299.AUKG01000002_gene4389 2.028e-140 460.0 COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4CPR5@84995|Rubrobacteria 84995|Rubrobacteria E Pyridoxal-dependent decarboxylase conserved domain - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC MMS1_k127_2284532_30 2074.JNYD01000039_gene2945 2.296e-66 237.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4E0UJ@85010|Pseudonocardiales 201174|Actinobacteria IQ short chain dehydrogenase - - - - - - - - - - - - adh_short MMS1_k127_2284532_55 1007103.AFHW01000004_gene4512 3.638e-40 153.0 COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,4HDPM@91061|Bacilli,26RJB@186822|Paenibacillaceae 91061|Bacilli S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt MMS1_k127_2284532_74 1122622.ATWJ01000015_gene570 2.679e-27 119.0 COG3797@1|root,COG3797@2|Bacteria,2HR3Y@201174|Actinobacteria,4FI7K@85021|Intrasporangiaceae 201174|Actinobacteria S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 MMS1_k127_2284532_4 1313172.YM304_11100 4.161e-200 652.0 COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4CMSA@84992|Acidimicrobiia 84992|Acidimicrobiia E Peptidase family M1 domain - - - ko:K08776 - - - - ko00000,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 MMS1_k127_2284532_63 67352.JODS01000002_gene1281 2.315e-36 144.0 COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria 201174|Actinobacteria S YbaK prolyl-tRNA synthetase associated region - - - - - - - - - - - - tRNA_edit MMS1_k127_2284532_35 1415166.NONO_c62950 1.082e-61 221.0 COG4122@1|root,COG4122@2|Bacteria,2IG30@201174|Actinobacteria,4G64J@85025|Nocardiaceae 201174|Actinobacteria S Putative methyltransferase - - - - - - - - - - - - Methyltransf_20,Methyltransf_25 MMS1_k127_2284532_90 1435356.Y013_24345 0.0006341 44.0 2BIFZ@1|root,32CNJ@2|Bacteria,2HIWJ@201174|Actinobacteria,4G4W2@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2284532_11 1283283.ATXA01000021_gene2875 2.29e-152 494.0 COG0038@1|root,COG0038@2|Bacteria,2GPPN@201174|Actinobacteria 201174|Actinobacteria P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC MMS1_k127_2284532_70 1206741.BAFX01000089_gene4858 1.426e-33 138.0 COG2808@1|root,COG2808@2|Bacteria,2IEXV@201174|Actinobacteria,4G79G@85025|Nocardiaceae 201174|Actinobacteria K Putative FMN-binding domain - - - ko:K07734 - - - - ko00000,ko03000 - - - FMN_bind_2 MMS1_k127_2284532_83 1125971.ASJB01000045_gene3965 2.249e-17 91.0 COG0454@1|root,COG0456@2|Bacteria,2GQGN@201174|Actinobacteria,4E6J0@85010|Pseudonocardiales 201174|Actinobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_2284532_82 1313172.YM304_11730 7.708e-18 92.0 COG0454@1|root,COG0456@2|Bacteria,2IMKI@201174|Actinobacteria,4CNE6@84992|Acidimicrobiia 84992|Acidimicrobiia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 MMS1_k127_2284532_48 1211815.CBYP010000073_gene3660 3.953e-51 194.0 COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4ET4R@85013|Frankiales 201174|Actinobacteria S Protein of unknown function (DUF3048) C-terminal domain yerB - - - - - - - - - - - DUF3048,DUF3048_C MMS1_k127_2284532_33 649831.L083_4644 4.452e-63 227.0 COG0596@1|root,COG0596@2|Bacteria,2IFCI@201174|Actinobacteria,4DC31@85008|Micromonosporales 201174|Actinobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1 MMS1_k127_2284532_14 1463900.JOIX01000035_gene3787 4.113e-148 481.0 COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria 201174|Actinobacteria E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase MMS1_k127_2284532_89 646529.Desaci_4543 0.0001782 56.0 COG2247@1|root,COG2372@1|root,COG5492@1|root,COG2247@2|Bacteria,COG2372@2|Bacteria,COG5492@2|Bacteria,1UIDD@1239|Firmicutes,25EIH@186801|Clostridia,264RK@186807|Peptococcaceae 186801|Clostridia M Fibronectin type 3 domain - - - - - - - - - - - - CW_binding_2,fn3 MMS1_k127_2284532_87 1109445.AGSX01000099_gene3447 3.2e-07 65.0 COG2885@1|root,COG2885@2|Bacteria,1REH1@1224|Proteobacteria,1S4WV@1236|Gammaproteobacteria,1YZRJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Belongs to the ompA family - - - - - - - - - - - - DUF4398,OmpA MMS1_k127_2284532_7 1123320.KB889686_gene602 6.658e-165 535.0 COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria 201174|Actinobacteria E decarboxylase ddc - - - - - - - - - - - Pyridoxal_deC MMS1_k127_2284532_28 1313172.YM304_02490 4.738e-70 248.0 COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CN0G@84992|Acidimicrobiia 84992|Acidimicrobiia E Prephenate dehydratase pheA - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDT MMS1_k127_2284532_88 596151.DesfrDRAFT_1582 1.554e-05 54.0 COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,42VQ5@68525|delta/epsilon subdivisions,2WSX2@28221|Deltaproteobacteria,2MGGZ@213115|Desulfovibrionales 28221|Deltaproteobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG MMS1_k127_2284532_86 313606.M23134_08356 1.108e-07 54.0 COG0300@1|root,COG0300@2|Bacteria,4PMEV@976|Bacteroidetes 976|Bacteroidetes S KR domain - - - - - - - - - - - - adh_short MMS1_k127_2324044_0 2002.JOEQ01000008_gene1116 9.42e-112 402.0 COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4ENN0@85012|Streptosporangiales 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - AAA_16,GerE MMS1_k127_2324044_2 525909.Afer_0279 1.785e-55 200.0 2A18G@1|root,30PEU@2|Bacteria,2IGED@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2324044_3 512565.AMIS_34780 5.277e-34 134.0 2E4HJ@1|root,32ZCP@2|Bacteria,2IIYC@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2324044_1 35754.JNYJ01000012_gene927 1.619e-59 218.0 COG0451@1|root,COG0451@2|Bacteria,2GP01@201174|Actinobacteria,4D8DK@85008|Micromonosporales 201174|Actinobacteria GM Nad-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase MMS1_k127_2342477_29 1206741.BAFX01000118_gene7377 5.374e-86 308.0 COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4G037@85025|Nocardiaceae 201174|Actinobacteria L Recombinase zinc beta ribbon domain - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom MMS1_k127_2342477_61 1382356.JQMP01000003_gene2348 5.776e-44 167.0 COG0691@1|root,COG0691@2|Bacteria,2G6NE@200795|Chloroflexi,27YCP@189775|Thermomicrobia 189775|Thermomicrobia O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB MMS1_k127_2342477_23 1313172.YM304_27700 1.734e-93 313.0 COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4CMXE@84992|Acidimicrobiia 84992|Acidimicrobiia J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C MMS1_k127_2342477_53 1313172.YM304_27690 7.883e-50 184.0 COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CNBV@84992|Acidimicrobiia 84992|Acidimicrobiia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like MMS1_k127_2342477_67 1348338.ADILRU_1642 9.495e-34 138.0 COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria,4FNT5@85023|Microbacteriaceae 201174|Actinobacteria S ATP-dependent protease La (LON) substrate-binding domain - - 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg MMS1_k127_2342477_52 1179773.BN6_66640 1.864e-51 185.0 COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4E3SA@85010|Pseudonocardiales 201174|Actinobacteria O FKBP-type peptidyl-prolyl cis-trans isomerase fkbP - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C MMS1_k127_2342477_44 82654.Pse7367_0771 1.476e-63 223.0 COG0740@1|root,COG0740@2|Bacteria,1G126@1117|Cyanobacteria,1H7H5@1150|Oscillatoriales 1117|Cyanobacteria OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP3 - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease MMS1_k127_2342477_36 525909.Afer_1748 1.979e-76 267.0 COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4CNBI@84992|Acidimicrobiia 84992|Acidimicrobiia U ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane MMS1_k127_2342477_28 1120947.ATUX01000005_gene1739 2.342e-87 303.0 COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4D3DP@85005|Actinomycetales 201174|Actinobacteria GM ABC transporter, ATP-binding protein rfbB2 - 3.6.3.40 ko:K01990,ko:K09691,ko:K09693 ko02010,map02010 M00250,M00251,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.103,3.A.1.104 - - ABC_tran,Wzt_C MMS1_k127_2342477_69 472759.Nhal_2173 5.006e-27 120.0 COG0560@1|root,COG0560@2|Bacteria,1RKIX@1224|Proteobacteria,1T0J3@1236|Gammaproteobacteria,1X2MH@135613|Chromatiales 135613|Chromatiales E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD MMS1_k127_2342477_20 1194972.MVAC_29348 1.454e-107 355.0 COG0667@1|root,COG0667@2|Bacteria,2GJ6R@201174|Actinobacteria,2329S@1762|Mycobacteriaceae 201174|Actinobacteria C aldo keto reductase - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red MMS1_k127_2342477_3 1333998.M2A_0895 2.275e-168 552.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C MMS1_k127_2342477_43 1229780.BN381_450038 7.568e-64 223.0 COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,3UWI4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T MMS1_k127_2342477_62 469383.Cwoe_3260 5.612e-43 161.0 COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CQCJ@84995|Rubrobacteria 84995|Rubrobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase MMS1_k127_2342477_55 1476583.DEIPH_ctg011orf0070 6.545e-49 189.0 COG0657@1|root,COG0657@2|Bacteria 2|Bacteria I acetylesterase activity - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 MMS1_k127_2342477_49 929712.KI912613_gene3425 4.315e-56 207.0 COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria,4CQ6I@84995|Rubrobacteria 84995|Rubrobacteria ET extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 MMS1_k127_2342477_26 426114.THI_1062 5.685e-89 303.0 COG0765@1|root,COG0765@2|Bacteria,1MXJW@1224|Proteobacteria,2VK7B@28216|Betaproteobacteria,1KNTX@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component artQ - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 MMS1_k127_2342477_21 1172180.KB911781_gene4403 1.253e-105 351.0 COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria 201174|Actinobacteria E ABC transporter, ATP-binding protein atrC - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran MMS1_k127_2342477_30 266117.Rxyl_2399 2.563e-83 293.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4CPIW@84995|Rubrobacteria 84995|Rubrobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 MMS1_k127_2342477_39 1160137.KB907310_gene4568 3.095e-69 242.0 COG0778@1|root,COG0778@2|Bacteria,2GKG5@201174|Actinobacteria,4G04D@85025|Nocardiaceae 201174|Actinobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase MMS1_k127_2342477_63 1121877.JQKF01000018_gene2557 7.695e-43 168.0 COG1511@1|root,COG1511@2|Bacteria,2I6VG@201174|Actinobacteria,4CNCD@84992|Acidimicrobiia 84992|Acidimicrobiia S ABC-2 family transporter protein - - - - - - - - - - - - - MMS1_k127_2342477_18 471857.Svir_39130 4.866e-109 360.0 COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4DYBC@85010|Pseudonocardiales 201174|Actinobacteria V ABC-type multidrug transport system, ATPase component drrA_3 - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2342477_68 525909.Afer_0199 1.121e-28 120.0 COG0735@1|root,COG0735@2|Bacteria,2HGZ6@201174|Actinobacteria,4CNZA@84992|Acidimicrobiia 84992|Acidimicrobiia P Ferric uptake regulator family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR MMS1_k127_2342477_33 1323361.JPOC01000086_gene2084 4.045e-81 276.0 COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4FXDF@85025|Nocardiaceae 201174|Actinobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR MMS1_k127_2342477_12 1229780.BN381_10277 1.027e-122 402.0 COG2070@1|root,COG2070@2|Bacteria,2GKA6@201174|Actinobacteria,3UXGG@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - NMO MMS1_k127_2342477_64 1171373.PACID_02050 2.32e-42 170.0 COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4DNGP@85009|Propionibacteriales 201174|Actinobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 MMS1_k127_2342477_4 326424.FRAAL1232 1.754e-159 519.0 COG0477@1|root,COG0477@2|Bacteria,2GJ09@201174|Actinobacteria,4ES1I@85013|Frankiales 201174|Actinobacteria P drug resistance transporter, EmrB QacA subfamily - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1 MMS1_k127_2342477_89 1095772.CAHH01000059_gene1400 1.62e-06 55.0 2E49S@1|root,32Z5G@2|Bacteria,2IHN1@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF3040) - - - - - - - - - - - - DUF3040 MMS1_k127_2342477_85 861299.J421_2311 1.255e-08 62.0 2FKCY@1|root,34C0C@2|Bacteria,1ZU3I@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - MMS1_k127_2342477_57 330084.JNYZ01000011_gene7472 2.074e-48 178.0 COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4DXRY@85010|Pseudonocardiales 201174|Actinobacteria L PFAM HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 MMS1_k127_2342477_75 935866.JAER01000024_gene3108 2.518e-21 101.0 COG0095@1|root,COG0095@2|Bacteria,2GTPJ@201174|Actinobacteria 201174|Actinobacteria H Lipoate-protein ligase - - - - - - - - - - - - - MMS1_k127_2342477_76 525909.Afer_1253 1.992e-20 98.0 COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4CNC7@84992|Acidimicrobiia 84992|Acidimicrobiia K MraZ protein, putative antitoxin-like mraZ - - ko:K03925 - - - - ko00000 - - - MraZ MMS1_k127_2342477_41 1229780.BN381_140015 1.506e-64 233.0 COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,3UWFR@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 MMS1_k127_2342477_15 1121877.JQKF01000014_gene32 2.177e-115 394.0 COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4CN0Q@84992|Acidimicrobiia 84992|Acidimicrobiia M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase MMS1_k127_2342477_25 269084.syc2470_c 3.17e-90 321.0 COG0769@1|root,COG0769@2|Bacteria,1G0HH@1117|Cyanobacteria,1GZ2T@1129|Synechococcus 1117|Cyanobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M MMS1_k127_2342477_14 1121877.JQKF01000014_gene30 4.799e-119 392.0 COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CMYF@84992|Acidimicrobiia 84992|Acidimicrobiia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 MMS1_k127_2342477_42 868595.Desca_2343 2.765e-64 236.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2619Y@186807|Peptococcaceae 186801|Clostridia D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE MMS1_k127_2342477_54 477974.Daud_1436 2.454e-49 191.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,260TT@186807|Peptococcaceae 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 MMS1_k127_2342477_32 1151119.KB895507_gene233 7.211e-83 292.0 COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,1W7MP@1268|Micrococcaceae 201174|Actinobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M MMS1_k127_2342477_37 525909.Afer_1243 6.977e-76 265.0 COG0812@1|root,COG0812@2|Bacteria,2HG0Y@201174|Actinobacteria,4CMXR@84992|Acidimicrobiia 84992|Acidimicrobiia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C MMS1_k127_2342477_88 1169154.KB897783_gene4543 2.121e-07 63.0 COG1589@1|root,COG1589@2|Bacteria,2H4A4@201174|Actinobacteria 201174|Actinobacteria D cell division protein FtsQ ftsQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 MMS1_k127_2342477_6 1229780.BN381_140005 5.436e-143 462.0 COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,3UW88@52018|unclassified Actinobacteria (class) 201174|Actinobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin MMS1_k127_2342477_66 525909.Afer_1239 1.113e-35 145.0 COG0325@1|root,COG0325@2|Bacteria,2HGAF@201174|Actinobacteria,4CN9H@84992|Acidimicrobiia 84992|Acidimicrobiia S Alanine racemase, N-terminal domain - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N MMS1_k127_2342477_87 1173026.Glo7428_1474 1.804e-07 60.0 COG1799@1|root,COG1799@2|Bacteria,1G556@1117|Cyanobacteria 1117|Cyanobacteria D Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA sepF - - ko:K09772 - - - - ko00000,ko03036 - - - SepF MMS1_k127_2342477_86 1197906.CAJQ02000031_gene1855 1.103e-07 57.0 COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,3JZGE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S YGGT family MA20_25225 - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT MMS1_k127_2342477_82 1206732.BAGD01000056_gene2144 3.255e-09 68.0 COG3599@1|root,COG3599@2|Bacteria,2GMSC@201174|Actinobacteria,4FUEB@85025|Nocardiaceae 201174|Actinobacteria D DivIVA protein wag31 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - DivIVA MMS1_k127_2342477_81 1452536.JARE01000051_gene3069 2.999e-09 68.0 COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4FQIV@85023|Microbacteriaceae 201174|Actinobacteria T Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR MMS1_k127_2342477_78 1448389.BAVQ01000003_gene3437 5.539e-13 77.0 COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria 201174|Actinobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 MMS1_k127_2342477_40 1313172.YM304_19580 2.205e-66 239.0 COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4CN1X@84992|Acidimicrobiia 84992|Acidimicrobiia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 MMS1_k127_2342477_34 1121877.JQKF01000014_gene11 2.036e-79 280.0 COG0568@1|root,COG0568@2|Bacteria,2H445@201174|Actinobacteria,4CNJ9@84992|Acidimicrobiia 84992|Acidimicrobiia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 MMS1_k127_2342477_48 1121877.JQKF01000038_gene1837 4.495e-58 205.0 COG1959@1|root,COG1959@2|Bacteria,2HG5V@201174|Actinobacteria,4CN2Q@84992|Acidimicrobiia 84992|Acidimicrobiia K Transcriptional regulator - - - - - - - - - - - - Rrf2 MMS1_k127_2342477_60 68170.KL590470_gene10784 3.59e-44 167.0 291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4E2RM@85010|Pseudonocardiales 201174|Actinobacteria S Protein of unknown function (DUF2587) - - - - - - - - - - - - DUF2587 MMS1_k127_2342477_1 1229780.BN381_430072 0.0 1295.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,3UWBK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L DNA polymerase alpha chain like domain dnaE GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon MMS1_k127_2342477_46 1121877.JQKF01000027_gene2478 5.048e-62 220.0 2BWZ3@1|root,33X4C@2|Bacteria,2H5EF@201174|Actinobacteria,4CN6H@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2342477_91 525909.Afer_1632 0.000738 50.0 2ANCX@1|root,31DBG@2|Bacteria,2HGYA@201174|Actinobacteria,4CNYJ@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2342477_8 1229780.BN381_430065 9.902e-131 441.0 COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,3UWA8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH MMS1_k127_2342477_19 1449976.KALB_3564 2.435e-108 359.0 COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4E33B@85010|Pseudonocardiales 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS1_k127_2342477_9 525909.Afer_1575 1.223e-130 431.0 COG4213@1|root,COG4213@2|Bacteria,2GKRE@201174|Actinobacteria 201174|Actinobacteria G ABC transporter substrate-binding protein xylF - - ko:K10543 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - Peripla_BP_4 MMS1_k127_2342477_27 1125971.ASJB01000042_gene3457 4.845e-88 298.0 COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria,4DYDG@85010|Pseudonocardiales 201174|Actinobacteria G ABC transporter - - 3.6.3.17 ko:K10545 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.4 - - ABC_tran MMS1_k127_2342477_13 525909.Afer_1573 8.275e-120 399.0 COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10544 ko02010,map02010 M00215 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4 - - BPD_transp_2 MMS1_k127_2342477_50 479432.Sros_4018 2.545e-54 205.0 COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4EIDY@85012|Streptosporangiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain menE GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007 4.2.1.113,6.2.1.26 ko:K01911,ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030,R04031 RC00004,RC00014,RC01053 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C MMS1_k127_2342477_7 1121877.JQKF01000027_gene2463 2.309e-137 444.0 COG0447@1|root,COG0447@2|Bacteria,2GK5G@201174|Actinobacteria,4CMXU@84992|Acidimicrobiia 84992|Acidimicrobiia H Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 MMS1_k127_2342477_45 397278.JOJN01000002_gene343 2.217e-62 228.0 COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4DNAI@85009|Propionibacteriales 201174|Actinobacteria H Belongs to the MenA family. Type 1 subfamily menA GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA MMS1_k127_2342477_56 1313172.YM304_23990 1.185e-48 186.0 COG2267@1|root,COG2267@2|Bacteria,2GYP0@201174|Actinobacteria 201174|Actinobacteria I Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH - 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_6 MMS1_k127_2342477_17 1343740.M271_03650 6.457e-112 381.0 COG1165@1|root,COG1165@2|Bacteria,2GMEB@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N MMS1_k127_2342477_47 1123320.KB889719_gene7214 6.801e-62 224.0 COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria 201174|Actinobacteria O Cytochrome c biogenesis protein ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD MMS1_k127_2342477_11 357808.RoseRS_2069 3.329e-127 429.0 COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi,375RR@32061|Chloroflexia 32061|Chloroflexia J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b MMS1_k127_2342477_77 525909.Afer_0595 1.574e-16 87.0 2ANAN@1|root,31D8Y@2|Bacteria,2HGVW@201174|Actinobacteria,4CNX0@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2342477_38 1313172.YM304_20280 2.52e-74 257.0 28IRH@1|root,2Z8QX@2|Bacteria,2GJW6@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2342477_59 1121877.JQKF01000024_gene2390 6.809e-46 174.0 COG0694@1|root,COG0694@2|Bacteria,2HGAJ@201174|Actinobacteria,4CN9Q@84992|Acidimicrobiia 84992|Acidimicrobiia O NifU-like domain - - - ko:K07400 - - - - ko00000 - - - NifU MMS1_k127_2342477_5 1121877.JQKF01000024_gene2399 4.018e-158 507.0 COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4CMPX@84992|Acidimicrobiia 84992|Acidimicrobiia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt MMS1_k127_2342477_74 1203556.HMPREF1478_01733 5.522e-22 104.0 COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4D5CA@85005|Actinomycetales 201174|Actinobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI MMS1_k127_2342477_31 1229780.BN381_50134 5.823e-83 287.0 COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,3UWGT@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829,ko:K16020 ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230 M00022 R02412,R03083,R06592 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI MMS1_k127_2342477_65 1229780.BN381_50135 1.972e-41 156.0 COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,3UWWA@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786,ko:K16021 ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230 M00022 R03084,R06593 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II MMS1_k127_2342477_35 1121877.JQKF01000024_gene2404 1.927e-77 263.0 COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CMZZ@84992|Acidimicrobiia 84992|Acidimicrobiia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C MMS1_k127_2342477_72 1229780.BN381_50137 7.123e-24 108.0 COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,3UWXH@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0008150,GO:0040007 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB MMS1_k127_2342477_84 471852.Tcur_1815 9.164e-09 60.0 2EA32@1|root,33485@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_2342477_51 525909.Afer_1709 3.708e-54 201.0 arCOG07408@1|root,2ZWPP@2|Bacteria,2HGM2@201174|Actinobacteria,4CNJ3@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2342477_22 525909.Afer_1708 1.132e-97 329.0 COG1622@1|root,COG1622@2|Bacteria,2HGN7@201174|Actinobacteria,4CNP4@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome C oxidase subunit II, periplasmic domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 MMS1_k127_2342477_2 525909.Afer_1707 4.561e-235 744.0 COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4CNMG@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 MMS1_k127_2342477_70 525909.Afer_1706 1.469e-26 117.0 2BRR4@1|root,32KQW@2|Bacteria,2HGNJ@201174|Actinobacteria,4CNPP@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2342477_79 1111479.AXAR01000010_gene2593 3.232e-12 79.0 COG1999@1|root,COG1999@2|Bacteria,1W0ZX@1239|Firmicutes 1239|Firmicutes S SCO1/SenC - - - - - - - - - - - - SCO1-SenC MMS1_k127_2342477_80 543632.JOJL01000023_gene1836 1.62e-11 69.0 2EA32@1|root,33485@2|Bacteria,2IN6C@201174|Actinobacteria,4DEKJ@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2342477_71 1198114.AciX9_2157 1.628e-26 121.0 COG3336@1|root,COG3336@2|Bacteria,3Y3CM@57723|Acidobacteria,2JKAF@204432|Acidobacteriia 204432|Acidobacteriia S PFAM Cytochrome c oxidase caa3-type, assembly factor CtaG-related - - - - - - - - - - - - Caa3_CtaG MMS1_k127_2342477_58 1463841.JOIR01000001_gene6946 8.18e-47 175.0 COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria 201174|Actinobacteria F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran MMS1_k127_2342477_24 1121354.AQUV01000001_gene1721 4.503e-93 319.0 COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,22K2F@1653|Corynebacteriaceae 201174|Actinobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N MMS1_k127_2342477_16 1229780.BN381_50140 2.496e-114 387.0 COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,3UWBY@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 MMS1_k127_2342477_10 1229780.BN381_50141 8.411e-129 429.0 COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,3UWBX@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Carbamoyl-phosphate synthase small chain, CPSase domain carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1383 CPSase_sm_chain,GATase MMS1_k127_2342477_0 1229780.BN381_50144 0.0 1342.0 COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,3UW8D@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS MMS1_k127_2342477_73 1313172.YM304_20470 4.493e-23 102.0 COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CN0R@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the conversion of dihydroorotate to orotate pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh MMS1_k127_2436716_114 1114959.SZMC14600_09054 5.297e-45 178.0 COG0582@1|root,COG0582@2|Bacteria,2I9QS@201174|Actinobacteria,4DYW3@85010|Pseudonocardiales 201174|Actinobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase MMS1_k127_2436716_145 525909.Afer_1887 5.282e-31 135.0 COG2385@1|root,COG2385@2|Bacteria,2HGNA@201174|Actinobacteria,4CNPA@84992|Acidimicrobiia 84992|Acidimicrobiia D sporulation resulting in formation of a cellular spore - - - - - - - - - - - - - MMS1_k127_2436716_163 1449347.JQLN01000007_gene983 1.001e-18 94.0 COG1752@1|root,COG1752@2|Bacteria,2IA6V@201174|Actinobacteria 201174|Actinobacteria S Phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin MMS1_k127_2436716_85 1051632.TPY_1473 5.469e-66 238.0 COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,249X0@186801|Clostridia 186801|Clostridia S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 MMS1_k127_2436716_129 105422.BBPM01000094_gene5281 2.528e-36 145.0 2E39M@1|root,32Y96@2|Bacteria,2IITE@201174|Actinobacteria,2NJ8S@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_42 1056816.JAFQ01000004_gene6261 1.036e-99 349.0 COG2227@1|root,COG2227@2|Bacteria,2GM7A@201174|Actinobacteria,4FZQY@85025|Nocardiaceae 201174|Actinobacteria H Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25 MMS1_k127_2436716_24 1320556.AVBP01000030_gene129 2.226e-126 411.0 COG0596@1|root,COG0596@2|Bacteria,1QU30@1224|Proteobacteria,2TSNY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the peptidase S33 family pip2 - 3.5.1.101 ko:K18457 - - - - ko00000,ko01000 - - - Abhydrolase_1 MMS1_k127_2436716_80 1122138.AQUZ01000015_gene6881 2.903e-68 243.0 COG0524@1|root,COG0524@2|Bacteria,2IA3T@201174|Actinobacteria,4DUEH@85009|Propionibacteriales 201174|Actinobacteria G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB MMS1_k127_2436716_116 1430331.EP10_13445 9.647e-45 166.0 COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,4HHKH@91061|Bacilli,1WHCN@129337|Geobacillus 91061|Bacilli S Uncharacterised protein family UPF0066 - - - - - - - - - - - - UPF0066 MMS1_k127_2436716_112 1136417.AZWE01000022_gene2632 3.213e-46 173.0 COG1435@1|root,COG1435@2|Bacteria,2GP1W@201174|Actinobacteria,4D9CP@85008|Micromonosporales 201174|Actinobacteria F thymidine kinase tdk GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK MMS1_k127_2436716_64 1278073.MYSTI_07001 2.008e-84 291.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NQ1@68525|delta/epsilon subdivisions,2X5KW@28221|Deltaproteobacteria,2YV1U@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK MMS1_k127_2436716_40 419947.MRA_0941 2.501e-100 334.0 COG1117@1|root,COG1117@2|Bacteria,2H3XA@201174|Actinobacteria,23D22@1762|Mycobacteriaceae 201174|Actinobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran MMS1_k127_2436716_36 419947.MRA_0942 1.231e-104 360.0 COG0226@1|root,COG0226@2|Bacteria,2IDU5@201174|Actinobacteria,23CM7@1762|Mycobacteriaceae 201174|Actinobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS1 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042301,GO:0042594,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071496,GO:0071944 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 MMS1_k127_2436716_32 419947.MRA_0943 5.127e-112 372.0 COG0573@1|root,COG0573@2|Bacteria,2ISS5@201174|Actinobacteria,23CM1@1762|Mycobacteriaceae 201174|Actinobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 MMS1_k127_2436716_71 487521.OCU_40940 9.93e-79 281.0 COG0581@1|root,COG0581@2|Bacteria,2H3XE@201174|Actinobacteria,23D51@1762|Mycobacteriaceae 201174|Actinobacteria P Binding-protein-dependent transport system inner membrane component pstA2 - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 MMS1_k127_2436716_23 1206733.BAGC01000040_gene1423 5.513e-133 438.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4FUDW@85025|Nocardiaceae 201174|Actinobacteria J Belongs to the amidase family bam - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase MMS1_k127_2436716_166 911045.PSE_3750 3.398e-17 88.0 COG0454@1|root,COG0456@2|Bacteria,1RH0C@1224|Proteobacteria,2U9B4@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases phnO - - - - - - - - - - - Acetyltransf_1 MMS1_k127_2436716_115 266117.Rxyl_2353 7.944e-45 167.0 COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4CSPT@84995|Rubrobacteria 84995|Rubrobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA MMS1_k127_2436716_142 1449353.JQMQ01000004_gene6205 9.792e-32 128.0 COG0599@1|root,COG0599@2|Bacteria,2IRPW@201174|Actinobacteria,2NMXI@228398|Streptacidiphilus 201174|Actinobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD MMS1_k127_2436716_159 1121877.JQKF01000010_gene755 3.156e-23 105.0 COG0694@1|root,COG0694@2|Bacteria,2HGE4@201174|Actinobacteria,4CNCF@84992|Acidimicrobiia 84992|Acidimicrobiia O NifU-like domain - - - - - - - - - - - - NifU MMS1_k127_2436716_169 1120917.AQXM01000040_gene928 6.255e-15 80.0 COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,1W9X6@1268|Micrococcaceae 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 MMS1_k127_2436716_47 1089453.GOSPT_099_00580 9.032e-96 329.0 COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,4GC6F@85026|Gordoniaceae 201174|Actinobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 MMS1_k127_2436716_12 1313172.YM304_10130 1.558e-178 571.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria 2|Bacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_2436716_22 1169154.KB897788_gene766 4.065e-137 451.0 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 MMS1_k127_2436716_59 28042.GU90_00775 2.33e-89 300.0 COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4DZB1@85010|Pseudonocardiales 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 MMS1_k127_2436716_41 1313172.YM304_09250 3.477e-100 341.0 COG3387@1|root,COG3387@2|Bacteria,2GKU7@201174|Actinobacteria,4CN1W@84992|Acidimicrobiia 84992|Acidimicrobiia G PFAM Glycoside hydrolase 15-related - - - - - - - - - - - - - MMS1_k127_2436716_88 1394178.AWOO02000066_gene152 6.813e-63 227.0 COG4122@1|root,COG4122@2|Bacteria,2GQ0Z@201174|Actinobacteria,4EIH4@85012|Streptosporangiales 201174|Actinobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 MMS1_k127_2436716_138 1283283.ATXA01000013_gene3454 1.064e-32 135.0 COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria 201174|Actinobacteria O membrane - - - - - - - - - - - - UPF0016 MMS1_k127_2436716_10 1313172.YM304_11100 3.188e-195 652.0 COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4CMSA@84992|Acidimicrobiia 84992|Acidimicrobiia E Peptidase family M1 domain - - - ko:K08776 - - - - ko00000,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 MMS1_k127_2436716_56 1528106.JRJE01000032_gene2924 2.517e-90 308.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2JPGW@204441|Rhodospirillales 204441|Rhodospirillales G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB MMS1_k127_2436716_171 1122182.KB903835_gene4452 3.49e-12 71.0 2EA32@1|root,33485@2|Bacteria,2IN6C@201174|Actinobacteria,4DEKJ@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_176 1463887.KL590053_gene5308 5.596e-07 56.0 2E65S@1|root,334KP@2|Bacteria,2I5A9@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF3817) - - - - - - - - - - - - DUF3817 MMS1_k127_2436716_111 1157490.EL26_16980 1.983e-47 186.0 COG0584@1|root,COG0584@2|Bacteria,1TQ3Y@1239|Firmicutes,4HAI9@91061|Bacilli,279TU@186823|Alicyclobacillaceae 91061|Bacilli C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD MMS1_k127_2436716_91 1479623.JHEL01000012_gene1892 5.661e-62 225.0 COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4FKUK@85023|Microbacteriaceae 201174|Actinobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase MMS1_k127_2436716_8 1229780.BN381_130124 1.059e-198 631.0 COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,3UW6I@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g MMS1_k127_2436716_92 1313172.YM304_33030 8.305e-61 224.0 COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CN2X@84992|Acidimicrobiia 84992|Acidimicrobiia L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase MMS1_k127_2436716_185 83406.HDN1F_05830 6.296e-05 55.0 COG0797@1|root,COG0797@2|Bacteria 2|Bacteria M peptidoglycan binding rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1 MMS1_k127_2436716_75 1313172.YM304_33050 2.587e-73 257.0 COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CN5A@84992|Acidimicrobiia 84992|Acidimicrobiia J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits - - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD MMS1_k127_2436716_108 1313172.YM304_33060 1.468e-50 188.0 COG1947@1|root,COG1947@2|Bacteria,2HG8Y@201174|Actinobacteria,4CN6Y@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - - MMS1_k127_2436716_109 1380347.JNII01000005_gene2849 1.951e-50 185.0 COG1695@1|root,COG1695@2|Bacteria,2IFDN@201174|Actinobacteria,4ET5U@85013|Frankiales 201174|Actinobacteria K Transcriptional regulator yqjI - - - - - - - - - - - PadR MMS1_k127_2436716_173 1304865.JAGF01000001_gene1535 2.897e-11 70.0 COG1141@1|root,COG1141@2|Bacteria,2GX0G@201174|Actinobacteria 201174|Actinobacteria C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_15 MMS1_k127_2436716_38 1449347.JQLN01000001_gene517 4.758e-102 346.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,2M0G3@2063|Kitasatospora 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - - - - - - - - - - Complex1_51K,NADH_4Fe-4S,SLBB MMS1_k127_2436716_144 1449353.JQMQ01000005_gene440 3.122e-31 132.0 COG4097@1|root,COG4097@2|Bacteria,2GQH2@201174|Actinobacteria,2NG1I@228398|Streptacidiphilus 201174|Actinobacteria P Ferric reductase like transmembrane component - - - - - - - - - - - - Ferric_reduct MMS1_k127_2436716_100 33876.JNXY01000039_gene6642 1.66e-56 213.0 COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria,4DDH1@85008|Micromonosporales 201174|Actinobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE MMS1_k127_2436716_78 298653.Franean1_5310 6.368e-70 254.0 COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4ES13@85013|Frankiales 201174|Actinobacteria T signal transduction histidine kinase - - 2.7.13.3 ko:K07653 ko02020,map02020 M00460 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA MMS1_k127_2436716_63 351607.Acel_1595 2.496e-85 288.0 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4ERZW@85013|Frankiales 201174|Actinobacteria K Two component transcriptional regulator, winged helix family mprA GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07669,ko:K07672 ko02020,map02020 M00460,M00463 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_2436716_66 1160137.KB907308_gene6796 6.911e-83 284.0 COG0596@1|root,COG0596@2|Bacteria,2HHT8@201174|Actinobacteria,4G09S@85025|Nocardiaceae 201174|Actinobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 MMS1_k127_2436716_69 1329516.JPST01000015_gene810 2.773e-81 283.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,27B3E@186824|Thermoactinomycetaceae 91061|Bacilli M 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase MMS1_k127_2436716_33 1043493.BBLU01000004_gene2717 8.197e-110 368.0 COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria 201174|Actinobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N MMS1_k127_2436716_154 326424.FRAAL6267 1.566e-26 120.0 COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4ESJF@85013|Frankiales 201174|Actinobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C MMS1_k127_2436716_122 525909.Afer_1595 1.031e-41 160.0 COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4CN75@84992|Acidimicrobiia 84992|Acidimicrobiia J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro MMS1_k127_2436716_4 469371.Tbis_3135 8.992e-274 880.0 COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4DXZU@85010|Pseudonocardiales 201174|Actinobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF MMS1_k127_2436716_76 1313172.YM304_33140 8.225e-71 256.0 COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,4CN31@84992|Acidimicrobiia 84992|Acidimicrobiia S MazG nucleotide pyrophosphohydrolase domain - - - ko:K02499 - - - - ko00000,ko03036 - - - MazG MMS1_k127_2436716_11 1121378.KB899716_gene461 1.603e-180 579.0 COG0148@1|root,COG0148@2|Bacteria,1WIST@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N MMS1_k127_2436716_99 1123322.KB904684_gene4794 6.759e-57 218.0 COG0248@1|root,COG1507@1|root,COG0248@2|Bacteria,COG1507@2|Bacteria,2GJBN@201174|Actinobacteria 201174|Actinobacteria FP Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA MMS1_k127_2436716_84 1313172.YM304_33450 2.935e-66 232.0 COG1670@1|root,COG1670@2|Bacteria,2HFKU@201174|Actinobacteria,4CP4F@84992|Acidimicrobiia 84992|Acidimicrobiia J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 MMS1_k127_2436716_120 298654.FraEuI1c_5118 2.749e-42 167.0 COG0463@1|root,COG1287@1|root,COG4981@1|root,COG0463@2|Bacteria,COG1287@2|Bacteria,COG4981@2|Bacteria,2GMA5@201174|Actinobacteria,4EXE6@85013|Frankiales 201174|Actinobacteria I Domain of unknown function (DUF3367) aftD GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - ko:K16648 - - - - ko00000,ko01000,ko01003 - - - DUF3367,F5_F8_type_C MMS1_k127_2436716_157 105422.BBPM01000068_gene445 1.965e-23 113.0 COG0791@1|root,COG0791@2|Bacteria,2GMK4@201174|Actinobacteria,2NFB8@228398|Streptacidiphilus 201174|Actinobacteria M NlpC/P60 family - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - DUF4226,NLPC_P60 MMS1_k127_2436716_152 1274.HX89_07385 1.286e-27 116.0 2E6D0@1|root,3310N@2|Bacteria,2GQP8@201174|Actinobacteria,1ZW9H@145357|Dermacoccaceae 201174|Actinobacteria S Protein of unknown function (DUF3054) - - - - - - - - - - - - DUF3054 MMS1_k127_2436716_168 525909.Afer_0737 1.633e-15 87.0 2968S@1|root,2ZTIT@2|Bacteria,2HEBZ@201174|Actinobacteria,4CNCH@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2436716_53 1229780.BN381_10183 1.126e-91 317.0 COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,3UXFW@52018|unclassified Actinobacteria (class) 201174|Actinobacteria JM Nucleotidyl transferase manC - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase MMS1_k127_2436716_89 1121877.JQKF01000001_gene1359 1.656e-62 222.0 COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CN3M@84992|Acidimicrobiia 84992|Acidimicrobiia C F420-0:Gamma-glutamyl ligase fbiB - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase MMS1_k127_2436716_68 446471.Xcel_3009 8.677e-82 290.0 COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4F40W@85017|Promicromonosporaceae 201174|Actinobacteria S Uncharacterised protein family UPF0052 cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 MMS1_k127_2436716_121 1121360.AUAQ01000011_gene379 3.184e-42 165.0 COG1680@1|root,COG1680@2|Bacteria,2GNVX@201174|Actinobacteria,22KR3@1653|Corynebacteriaceae 201174|Actinobacteria V Beta-lactamase class C and other penicillin binding proteins bla - - - - - - - - - - - Beta-lactamase MMS1_k127_2436716_175 525909.Afer_0742 1.033e-08 67.0 COG0438@1|root,COG0438@2|Bacteria,2GIVP@201174|Actinobacteria,4CN35@84992|Acidimicrobiia 84992|Acidimicrobiia M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS1_k127_2436716_118 525909.Afer_0743 2.17e-43 172.0 COG0438@1|root,COG0438@2|Bacteria,2GMEW@201174|Actinobacteria,4CNQH@84992|Acidimicrobiia 84992|Acidimicrobiia M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS1_k127_2436716_96 525909.Afer_0744 5.296e-57 213.0 COG0438@1|root,COG0438@2|Bacteria,2GK9J@201174|Actinobacteria,4CNNK@84992|Acidimicrobiia 84992|Acidimicrobiia M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS1_k127_2436716_83 1229780.BN381_10190 2.705e-66 239.0 COG1089@1|root,COG1089@2|Bacteria,2GNMA@201174|Actinobacteria 201174|Actinobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd MMS1_k127_2436716_35 1229780.BN381_10192 2.436e-106 383.0 COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,3UWUN@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3 MMS1_k127_2436716_5 525909.Afer_1606 1.368e-248 783.0 COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CMRD@84992|Acidimicrobiia 84992|Acidimicrobiia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 MMS1_k127_2436716_160 1121877.JQKF01000001_gene1298 1.808e-21 103.0 COG1266@1|root,COG1266@2|Bacteria,2H0BD@201174|Actinobacteria,4CNBE@84992|Acidimicrobiia 84992|Acidimicrobiia S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi MMS1_k127_2436716_30 1229780.BN381_10199 1.718e-116 410.0 COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria 201174|Actinobacteria S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - MMS1_k127_2436716_16 1121877.JQKF01000008_gene665 3.469e-162 522.0 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4CMU2@84992|Acidimicrobiia 84992|Acidimicrobiia G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV MMS1_k127_2436716_183 419947.MRA_1694A 8.879e-06 57.0 COG2835@1|root,COG2835@2|Bacteria,2GQID@201174|Actinobacteria,23B8B@1762|Mycobacteriaceae 201174|Actinobacteria S Trm112p-like protein - - - - - - - - - - - - Trm112p MMS1_k127_2436716_14 1445613.JALM01000004_gene4592 1.349e-171 547.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DX8J@85010|Pseudonocardiales 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N MMS1_k127_2436716_97 439481.Aboo_0746 5.602e-57 203.0 COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,3F2K2@33867|unclassified Euryarchaeota 28890|Euryarchaeota H 6,7-dimethyl-8-ribityllumazine synthase ribC - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase MMS1_k127_2436716_26 1246995.AFR_36125 4.47e-123 404.0 COG2141@1|root,COG2141@2|Bacteria,2GN4N@201174|Actinobacteria,4D924@85008|Micromonosporales 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase MMS1_k127_2436716_132 1449353.JQMQ01000005_gene264 1.909e-34 151.0 29BBV@1|root,2ZCHD@2|Bacteria,2I82W@201174|Actinobacteria,2NNJY@228398|Streptacidiphilus 201174|Actinobacteria S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA MMS1_k127_2436716_44 351607.Acel_2058 3.602e-97 334.0 COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4ETXZ@85013|Frankiales 201174|Actinobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap MMS1_k127_2436716_133 525909.Afer_1069 2.045e-34 141.0 2EFBW@1|root,3394U@2|Bacteria,2H758@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_31 272568.GDI3373 1.872e-115 400.0 COG4485@1|root,COG4485@2|Bacteria,1QGV0@1224|Proteobacteria 1224|Proteobacteria S polysaccharide biosynthetic process - - - - - - - - - - - - - MMS1_k127_2436716_104 388467.A19Y_2101 3.279e-53 209.0 COG0457@1|root,COG1216@1|root,COG0457@2|Bacteria,COG1216@2|Bacteria,1GQBE@1117|Cyanobacteria,1H7DT@1150|Oscillatoriales 1117|Cyanobacteria M glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2,RgpF,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8 MMS1_k127_2436716_153 390989.JOEG01000013_gene2472 2.215e-27 118.0 COG0454@1|root,COG0456@2|Bacteria,2GMXI@201174|Actinobacteria,4DF4J@85008|Micromonosporales 201174|Actinobacteria K Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_2436716_19 1051632.TPY_3730 8.472e-152 496.0 COG0477@1|root,COG0477@2|Bacteria,1UHPS@1239|Firmicutes 1239|Firmicutes EGP Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family xylE - - ko:K08138 - - - - ko00000,ko02000 2.A.1.1.3 - - Sugar_tr MMS1_k127_2436716_60 58344.JOEL01000003_gene1434 9.824e-89 311.0 COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria 201174|Actinobacteria Q Dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH MMS1_k127_2436716_158 1283283.ATXA01000004_gene4280 2.825e-23 104.0 2E8T5@1|root,3333Y@2|Bacteria,2IS1D@201174|Actinobacteria,4EWY4@85013|Frankiales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_17 1394178.AWOO02000092_gene1080 2.179e-161 515.0 COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4EHDM@85012|Streptosporangiales 201174|Actinobacteria C Aldo/keto reductase family yghZ - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red MMS1_k127_2436716_29 223184.AS25_11475 5.041e-119 387.0 COG0647@1|root,COG0647@2|Bacteria,2GJG6@201174|Actinobacteria,1W86Y@1268|Micrococcaceae 201174|Actinobacteria G Belongs to the HAD-like hydrolase superfamily nagD - - ko:K02566 - - - - ko00000 - - - Hydrolase_6,Hydrolase_like MMS1_k127_2436716_81 1313172.YM304_20400 1.365e-66 247.0 COG3463@1|root,COG3463@2|Bacteria 2|Bacteria T Predicted membrane protein (DUF2079) - - 2.7.13.3 ko:K07778 ko02020,map02020 M00479 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2079,HisKA_3 MMS1_k127_2436716_136 235985.BBPN01000009_gene3921 1.785e-33 133.0 2BWPS@1|root,345TK@2|Bacteria,2H99A@201174|Actinobacteria,2NMTR@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_188 235985.BBPN01000004_gene3100 0.0003226 54.0 COG4412@1|root,COG4412@2|Bacteria,2I8QH@201174|Actinobacteria,2NHSW@228398|Streptacidiphilus 201174|Actinobacteria O M6 family metalloprotease domain protein - - - - - - - - - - - - He_PIG MMS1_k127_2436716_123 1313172.YM304_13820 1.799e-41 161.0 COG2267@1|root,COG2267@2|Bacteria,2HM71@201174|Actinobacteria 201174|Actinobacteria I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_6 MMS1_k127_2436716_1 525909.Afer_1322 7.482e-320 998.0 COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4CMQM@84992|Acidimicrobiia 84992|Acidimicrobiia J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 MMS1_k127_2436716_124 479435.Kfla_5329 5.353e-41 158.0 COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,4DQV0@85009|Propionibacteriales 201174|Actinobacteria S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 MMS1_k127_2436716_95 1229780.BN381_10251 2.358e-58 215.0 COG2047@1|root,COG2047@2|Bacteria,2GK8I@201174|Actinobacteria 201174|Actinobacteria S PAC2 family - - - - - - - - - - - - PAC2 MMS1_k127_2436716_46 1229780.BN381_10252 3.767e-96 325.0 COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,3UX9P@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH MMS1_k127_2436716_90 1121877.JQKF01000015_gene75 5.365e-62 223.0 COG3118@1|root,COG3118@2|Bacteria,2GJ7B@201174|Actinobacteria,4CMY0@84992|Acidimicrobiia 84992|Acidimicrobiia O Tetratricopeptide repeat - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_20,Thioredoxin MMS1_k127_2436716_70 525909.Afer_1304 6.041e-79 274.0 COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria,4CNF4@84992|Acidimicrobiia 84992|Acidimicrobiia H Pterin binding enzyme - - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind MMS1_k127_2436716_134 1229780.BN381_10276 6.495e-34 143.0 COG1466@1|root,COG1466@2|Bacteria 2|Bacteria L DNA-directed DNA polymerase activity holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta MMS1_k127_2436716_170 1150399.AQYK01000001_gene1935 2.714e-14 83.0 COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4FPN2@85023|Microbacteriaceae 201174|Actinobacteria J Binds directly to 16S ribosomal RNA rpsT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p MMS1_k127_2436716_3 525909.Afer_1296 6.228e-281 873.0 COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CMUT@84992|Acidimicrobiia 84992|Acidimicrobiia M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C MMS1_k127_2436716_86 1313172.YM304_21110 2.178e-65 236.0 COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4CN2R@84992|Acidimicrobiia 84992|Acidimicrobiia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA MMS1_k127_2436716_37 222534.KB893783_gene5288 1.212e-103 349.0 COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4ERI5@85013|Frankiales 201174|Actinobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG MMS1_k127_2436716_149 1313172.YM304_21130 7.997e-29 125.0 COG1385@1|root,COG1385@2|Bacteria,2HGFD@201174|Actinobacteria,4CND1@84992|Acidimicrobiia 84992|Acidimicrobiia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA MMS1_k127_2436716_130 1382304.JNIL01000001_gene3278 8.709e-36 139.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,4HIG2@91061|Bacilli,27A28@186823|Alicyclobacillaceae 91061|Bacilli FG HIT domain hit - - ko:K02503 - - - - ko00000,ko04147 - - - HIT MMS1_k127_2436716_25 1229780.BN381_330095 1.698e-124 407.0 COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,3UWEM@52018|unclassified Actinobacteria (class) 201174|Actinobacteria T PhoH-like protein phoH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06217 - - - - ko00000 - - - PhoH MMS1_k127_2436716_146 1313172.YM304_23950 6.364e-31 128.0 COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CN8G@84992|Acidimicrobiia 84992|Acidimicrobiia S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 MMS1_k127_2436716_43 1121877.JQKF01000022_gene2275 7.075e-99 337.0 COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia 84992|Acidimicrobiia S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 MMS1_k127_2436716_72 1229780.BN381_330098 9.316e-77 273.0 COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,3UW9V@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 MMS1_k127_2436716_101 1048339.KB913029_gene4160 5.376e-55 203.0 COG0730@1|root,COG0730@2|Bacteria,2GNW8@201174|Actinobacteria,4ESDT@85013|Frankiales 201174|Actinobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE MMS1_k127_2436716_27 1313172.YM304_24190 1.172e-120 411.0 COG1199@1|root,COG1199@2|Bacteria,2GKT8@201174|Actinobacteria 201174|Actinobacteria KL helicase dinG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 MMS1_k127_2436716_45 525909.Afer_1266 2.471e-96 320.0 COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4CN13@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids - - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf MMS1_k127_2436716_131 1313172.YM304_24220 5.519e-35 147.0 COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CN8K@84992|Acidimicrobiia 84992|Acidimicrobiia L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N MMS1_k127_2436716_126 1283283.ATXA01000006_gene1947 7.417e-38 155.0 COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4ERIM@85013|Frankiales 201174|Actinobacteria L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 MMS1_k127_2436716_79 526225.Gobs_0849 7.737e-70 243.0 COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria,4ERIM@85013|Frankiales 201174|Actinobacteria L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 MMS1_k127_2436716_50 1313172.YM304_21150 1.423e-93 319.0 COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4CNTM@84992|Acidimicrobiia 84992|Acidimicrobiia C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM MMS1_k127_2436716_9 1229780.BN381_330109 1.644e-196 620.0 COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,3UW9K@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b MMS1_k127_2436716_61 1288826.MSNKSG1_14072 2.298e-88 309.0 COG0477@1|root,COG2814@2|Bacteria,1MVVW@1224|Proteobacteria,1RMXR@1236|Gammaproteobacteria,46CEW@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2436716_143 398580.Dshi_1603 1.482e-31 129.0 COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q protein possibly involved in aromatic compounds catabolism MA20_36950 - - - - - - - - - - - 4HBT MMS1_k127_2436716_20 1313172.YM304_22780 1.457e-144 479.0 COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4CMWH@84992|Acidimicrobiia 84992|Acidimicrobiia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 MMS1_k127_2436716_174 765420.OSCT_2866 1.699e-09 68.0 COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi,3750P@32061|Chloroflexia 32061|Chloroflexia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 MMS1_k127_2436716_57 595494.Tola_0988 4.255e-90 304.0 COG0289@1|root,COG0289@2|Bacteria,1RAV8@1224|Proteobacteria,1SJUS@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Dihydrodipicolinate reductase, C-terminus - - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N MMS1_k127_2436716_102 1123023.JIAI01000002_gene5579 2.041e-54 203.0 COG0330@1|root,COG0330@2|Bacteria,2GJ1U@201174|Actinobacteria,4DY3Q@85010|Pseudonocardiales 201174|Actinobacteria O SPFH domain Band 7 family hflK GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Band_7 MMS1_k127_2436716_182 1042156.CXIVA_07580 5.036e-06 56.0 COG1585@1|root,COG1585@2|Bacteria,1VAS9@1239|Firmicutes,24MRQ@186801|Clostridia 186801|Clostridia OU Psort location CytoplasmicMembrane, score - - - - - - - - - - - - NfeD MMS1_k127_2436716_179 164757.Mjls_2610 1.373e-06 57.0 2EC6I@1|root,33651@2|Bacteria,2IGU7@201174|Actinobacteria,2390H@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - PsiE MMS1_k127_2436716_117 1160137.KB907309_gene6050 1.912e-44 176.0 COG0431@1|root,COG0431@2|Bacteria,2GNFR@201174|Actinobacteria,4FW70@85025|Nocardiaceae 201174|Actinobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red MMS1_k127_2436716_139 1214101.BN159_2337 2.911e-32 134.0 COG0537@1|root,COG0537@2|Bacteria 2|Bacteria FG bis(5'-adenosyl)-triphosphatase activity hit - - ko:K02503 - - - - ko00000,ko04147 - - - HIT MMS1_k127_2436716_106 1121877.JQKF01000010_gene695 2.47e-51 198.0 COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4CN19@84992|Acidimicrobiia 84992|Acidimicrobiia EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2436716_34 1121877.JQKF01000003_gene1456 9.97e-107 361.0 COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4CMSI@84992|Acidimicrobiia 84992|Acidimicrobiia C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS1_k127_2436716_2 469383.Cwoe_4211 2.999e-301 932.0 COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4CQXA@84995|Rubrobacteria 84995|Rubrobacteria C Phosphoenolpyruvate carboxykinase C-terminal P-loop domain - - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N MMS1_k127_2436716_87 525909.Afer_0692 2.655e-63 229.0 COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4CNTJ@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C MMS1_k127_2436716_150 1229780.BN381_10342 1.341e-28 116.0 COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,3UX04@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Ribosomal L28 family rpmB GO:0003674,GO:0003735,GO:0005198 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 MMS1_k127_2436716_21 1313172.YM304_18510 8.457e-144 474.0 COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CMTA@84992|Acidimicrobiia 84992|Acidimicrobiia S Dak1_2 - - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 MMS1_k127_2436716_13 525909.Afer_1516 2.738e-176 581.0 COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4CMPC@84992|Acidimicrobiia 84992|Acidimicrobiia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge MMS1_k127_2436716_151 1313172.YM304_18580 1.153e-27 118.0 COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4CN8I@84992|Acidimicrobiia 84992|Acidimicrobiia L Conserved hypothetical protein 95 - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 MMS1_k127_2436716_103 525909.Afer_1514 3.148e-54 197.0 COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4CN4E@84992|Acidimicrobiia 84992|Acidimicrobiia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like MMS1_k127_2436716_147 1313172.YM304_18600 2.323e-30 132.0 COG0711@1|root,COG0711@2|Bacteria,2HG9T@201174|Actinobacteria,4CN89@84992|Acidimicrobiia 84992|Acidimicrobiia C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - - - - - - - - - - - MMS1_k127_2436716_148 1313172.YM304_18630 8.876e-30 126.0 COG1399@1|root,COG1399@2|Bacteria,2HGH0@201174|Actinobacteria,4CNEE@84992|Acidimicrobiia 84992|Acidimicrobiia S Uncharacterized ACR, COG1399 - - - ko:K07040 - - - - ko00000 - - - DUF177 MMS1_k127_2436716_161 1229780.BN381_330016 2.116e-20 93.0 COG0333@1|root,COG0333@2|Bacteria 2|Bacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p MMS1_k127_2436716_48 1313172.YM304_18650 1.983e-95 325.0 COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4CMRM@84992|Acidimicrobiia 84992|Acidimicrobiia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis MMS1_k127_2436716_165 1121877.JQKF01000004_gene1071 3.08e-17 84.0 COG0236@1|root,COG0236@2|Bacteria,2HG9V@201174|Actinobacteria,4CN8D@84992|Acidimicrobiia 84992|Acidimicrobiia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding MMS1_k127_2436716_113 1380354.JIAN01000006_gene1060 4.803e-46 177.0 COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4F0KY@85016|Cellulomonadaceae 201174|Actinobacteria K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm MMS1_k127_2436716_93 1313172.YM304_18680 6.118e-59 217.0 COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4CN5C@84992|Acidimicrobiia 84992|Acidimicrobiia L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates mutM - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS MMS1_k127_2436716_6 1229780.BN381_330023 1.427e-226 743.0 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,3UWCX@52018|unclassified Actinobacteria (class) 201174|Actinobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge MMS1_k127_2436716_62 1313172.YM304_18700 3.855e-87 302.0 COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CMY6@84992|Acidimicrobiia 84992|Acidimicrobiia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54 MMS1_k127_2436716_18 1313172.YM304_18720 5.444e-161 522.0 COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4CMPN@84992|Acidimicrobiia 84992|Acidimicrobiia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB MMS1_k127_2436716_155 1313172.YM304_18730 1.505e-25 109.0 COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CNAD@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal protein S16 rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 MMS1_k127_2436716_172 1313172.YM304_18740 7.587e-12 74.0 COG1837@1|root,COG1837@2|Bacteria 2|Bacteria L Belongs to the UPF0109 family CP_0960 GO:0008150,GO:0040007 - ko:K06960 - - - - ko00000 - - - KH_4 MMS1_k127_2436716_137 1313172.YM304_18750 9.527e-33 134.0 COG0806@1|root,COG0806@2|Bacteria,2HGD9@201174|Actinobacteria,4CNBG@84992|Acidimicrobiia 84992|Acidimicrobiia J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - RimM MMS1_k127_2436716_55 1229780.BN381_330038 2.033e-91 308.0 COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,3UWGW@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Acetyltransf_1,tRNA_m1G_MT MMS1_k127_2436716_105 526225.Gobs_4003 9.232e-53 188.0 COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4ESVQ@85013|Frankiales 201174|Actinobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 MMS1_k127_2436716_135 1713.JOFV01000004_gene3456 7.154e-34 132.0 2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4F1D7@85016|Cellulomonadaceae 201174|Actinobacteria S Protein of unknown function (DUF2469) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF2469 MMS1_k127_2436716_140 365528.KB891126_gene3224 3.513e-32 130.0 COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria 201174|Actinobacteria IQ pyridoxamine 5-phosphate - - - - - - - - - - - - Putative_PNPOx MMS1_k127_2436716_82 1122939.ATUD01000004_gene3901 1.583e-66 241.0 COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4CP9J@84995|Rubrobacteria 84995|Rubrobacteria L AP endonuclease family 2 - - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 MMS1_k127_2436716_7 251229.Chro_1612 8.981e-202 639.0 COG0114@1|root,COG0114@2|Bacteria,1G0AD@1117|Cyanobacteria 1117|Cyanobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 MMS1_k127_2436716_51 644283.Micau_1429 2.351e-93 321.0 COG2223@1|root,COG2223@2|Bacteria,2I3Y1@201174|Actinobacteria,4DB4I@85008|Micromonosporales 201174|Actinobacteria P Major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2436716_107 1206733.BAGC01000055_gene2940 4.945e-51 194.0 arCOG04740@1|root,31PZA@2|Bacteria,2GP15@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_54 67257.JODR01000001_gene779 1.484e-91 317.0 COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase M48B family htpX1 - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 MMS1_k127_2436716_77 469371.Tbis_1280 1.016e-70 246.0 COG1842@1|root,COG1842@2|Bacteria,2GP0K@201174|Actinobacteria,4E7TG@85010|Pseudonocardiales 201174|Actinobacteria KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 MMS1_k127_2436716_98 1120959.ATXF01000004_gene2949 6.63e-57 203.0 COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4FNKI@85023|Microbacteriaceae 201174|Actinobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE GO:0008150,GO:0040007 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3275c AIRC MMS1_k127_2436716_73 446470.Snas_0805 7.753e-76 268.0 COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria,4EY09@85014|Glycomycetales 201174|Actinobacteria F ATP-grasp domain purK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp MMS1_k127_2436716_65 479431.Namu_4273 9.895e-84 287.0 COG2141@1|root,COG2141@2|Bacteria,2GMRE@201174|Actinobacteria,4EU7W@85013|Frankiales 201174|Actinobacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Bac_luciferase MMS1_k127_2436716_119 1283283.ATXA01000008_gene3129 1.97e-42 162.0 COG1651@1|root,COG1651@2|Bacteria,2IT6U@201174|Actinobacteria 201174|Actinobacteria O DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA MMS1_k127_2436716_125 1313172.YM304_15500 1.239e-40 162.0 COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4CN3P@84992|Acidimicrobiia 84992|Acidimicrobiia L PD-(D/E)XK nuclease superfamily - - - ko:K07465 - - - - ko00000 - - - PDDEXK_1 MMS1_k127_2436716_94 1122939.ATUD01000004_gene3756 1.445e-58 219.0 COG0477@1|root,COG2814@2|Bacteria,2GJPT@201174|Actinobacteria,4CPPA@84995|Rubrobacteria 84995|Rubrobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 MMS1_k127_2436716_156 234267.Acid_2832 1.818e-23 103.0 COG1695@1|root,COG1695@2|Bacteria 2|Bacteria K negative regulation of transcription, DNA-templated - - - - - - - - - - - - PadR MMS1_k127_2436716_39 1121877.JQKF01000007_gene965 6.411e-101 341.0 COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4CNST@84992|Acidimicrobiia 84992|Acidimicrobiia L Phage integrase family - - - - - - - - - - - - Phage_integrase MMS1_k127_2436716_177 587753.EY04_09140 7.086e-07 54.0 2EU0C@1|root,33MHE@2|Bacteria,1QVER@1224|Proteobacteria,1SAIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 MMS1_k127_2436716_58 1121877.JQKF01000084_gene220 1.135e-89 312.0 COG3550@1|root,COG3550@2|Bacteria,2IH51@201174|Actinobacteria 201174|Actinobacteria S HipA domain protein - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C MMS1_k127_2436716_110 1229780.BN381_770002 2.397e-48 192.0 COG3385@1|root,COG3385@2|Bacteria,2GJUG@201174|Actinobacteria 201174|Actinobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 MMS1_k127_2436716_141 675635.Psed_6799 5.099e-32 130.0 COG3385@1|root,COG3385@2|Bacteria,2GJUG@201174|Actinobacteria,4E37H@85010|Pseudonocardiales 201174|Actinobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 MMS1_k127_2436716_187 1410668.JNKC01000016_gene993 7.901e-05 46.0 2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - MMS1_k127_2436716_127 443255.SCLAV_1841 4.451e-37 143.0 COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria 201174|Actinobacteria O PFAM globin glbO GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363 - ko:K06886 - - - - ko00000 - - - Bac_globin MMS1_k127_2436716_184 452863.Achl_1328 2.25e-05 54.0 COG3428@1|root,COG3428@2|Bacteria 2|Bacteria S Bacterial PH domain - - - - - - - - - - - - bPH_2 MMS1_k127_2436716_164 1229780.BN381_140045 1.42e-18 86.0 2ES7R@1|root,33JSG@2|Bacteria,2I1DU@201174|Actinobacteria,3UXPZ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_178 585531.HMPREF0063_11083 8.214e-07 53.0 2EGHN@1|root,33A9R@2|Bacteria,2HZFR@201174|Actinobacteria,4DSMW@85009|Propionibacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_52 1229780.BN381_140042 5.182e-92 315.0 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,3UXEM@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Glycosyl transferases group 1 pimB GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 MMS1_k127_2436716_128 525909.Afer_0938 1.341e-36 143.0 COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4CN9D@84992|Acidimicrobiia 84992|Acidimicrobiia I Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc MMS1_k127_2436716_186 1169161.KB897717_gene2944 7.607e-05 53.0 COG2141@1|root,COG2141@2|Bacteria,2GM7W@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase MMS1_k127_2436716_15 1313172.YM304_19190 3.528e-168 539.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CNS0@84992|Acidimicrobiia 84992|Acidimicrobiia E Aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 MMS1_k127_2436716_67 566466.NOR53_3532 2.002e-82 283.0 COG3386@1|root,COG3386@2|Bacteria,1QN8Y@1224|Proteobacteria,1S5PU@1236|Gammaproteobacteria,1J7F2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL MMS1_k127_2436716_28 215803.DB30_3097 1.245e-120 403.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,42M9Z@68525|delta/epsilon subdivisions,2WIYZ@28221|Deltaproteobacteria,2YU0Z@29|Myxococcales 28221|Deltaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N MMS1_k127_2436716_0 1121877.JQKF01000002_gene1700 0.0 1232.0 COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4CN7I@84992|Acidimicrobiia 84992|Acidimicrobiia F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC MMS1_k127_2436716_74 269798.CHU_0033 8.414e-74 275.0 2EQ7Y@1|root,33HU6@2|Bacteria,4NXWG@976|Bacteroidetes,47WEW@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - MMS1_k127_2436716_49 543632.JOJL01000056_gene279 9.915e-95 327.0 2DBQ2@1|root,2ZABR@2|Bacteria,2IF6C@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_181 649831.L083_1632 2.601e-06 59.0 2DENT@1|root,2ZNM7@2|Bacteria,2HWSD@201174|Actinobacteria,4DK7Z@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2436716_162 1237500.ANBA01000037_gene1570 5.646e-19 99.0 COG2842@1|root,COG2842@2|Bacteria,2I4XE@201174|Actinobacteria 201174|Actinobacteria S AAA domain - - - - - - - - - - - - AAA_22 MMS1_k127_2436716_167 194867.ALBQ01000043_gene1298 5.749e-17 95.0 COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1MXCK@1224|Proteobacteria,2U4QF@28211|Alphaproteobacteria,2K3F9@204457|Sphingomonadales 204457|Sphingomonadales L Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - HTH_23,Mu-transpos_C,rve MMS1_k127_2467260_4 469371.Tbis_1732 3.523e-52 194.0 COG2186@1|root,COG2186@2|Bacteria,2IAQ9@201174|Actinobacteria,4E5KH@85010|Pseudonocardiales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - dCache_1 MMS1_k127_2467260_3 469371.Tbis_1733 1.901e-68 242.0 COG2186@1|root,COG2186@2|Bacteria,2GKJM@201174|Actinobacteria,4E348@85010|Pseudonocardiales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - FCD,GntR MMS1_k127_2467260_2 1123250.KB908380_gene837 1.268e-141 473.0 COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes,4H3AP@909932|Negativicutes 909932|Negativicutes C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 MMS1_k127_2467260_5 1123250.KB908380_gene838 1.615e-48 192.0 COG2025@1|root,COG2025@2|Bacteria,1U8TB@1239|Firmicutes,4H5IT@909932|Negativicutes 909932|Negativicutes C Electron transfer flavoprotein FAD-binding domain - - - - - - - - - - - - ETF,ETF_alpha MMS1_k127_2467260_6 1123250.KB908380_gene839 1.923e-39 157.0 COG2086@1|root,COG2086@2|Bacteria,1W75F@1239|Firmicutes,4H8AB@909932|Negativicutes 909932|Negativicutes C Electron transfer flavoprotein domain - - - - - - - - - - - - ETF MMS1_k127_2467260_1 1123250.KB908380_gene841 8.506e-143 467.0 COG0247@1|root,COG0247@2|Bacteria,1TPG1@1239|Firmicutes 1239|Firmicutes C Fe-S oxidoreductase - - 1.8.98.1 ko:K08264 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 - R04540 RC00011 ko00000,ko00001,ko01000 - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8 MMS1_k127_2467260_0 1123250.KB908380_gene842 4.191e-172 554.0 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H300@909932|Negativicutes 909932|Negativicutes C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 MMS1_k127_2467260_8 1499689.CCNN01000004_gene177 3.781e-05 51.0 COG4766@1|root,COG4766@2|Bacteria,1V1X3@1239|Firmicutes,25DER@186801|Clostridia,36I1S@31979|Clostridiaceae 186801|Clostridia E Ethanolamine utilisation protein EutQ - - - ko:K04030 - - - - ko00000 - - - EutQ MMS1_k127_2467260_7 479433.Caci_1553 1.201e-16 79.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family prr1 - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_2522520_2 1288826.MSNKSG1_13832 3.736e-26 110.0 COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,46B8H@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 MMS1_k127_2522520_0 1033802.SSPSH_003692 1.949e-120 394.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve MMS1_k127_2522520_3 1304275.C41B8_09978 2.74e-21 105.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_4 MMS1_k127_2522520_4 1463887.KL590044_gene8348 1.749e-05 58.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Autotransporter,Big_2,Cadherin-like,Cytochrom_D1,Lactonase,PATR,SLH,fn3 MMS1_k127_2522520_1 1283299.AUKG01000001_gene2130 8.931e-59 231.0 COG2206@1|root,COG2373@1|root,COG2206@2|Bacteria,COG2373@2|Bacteria,2GJS8@201174|Actinobacteria 201174|Actinobacteria T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD,HD_5 MMS1_k127_2542586_2 525909.Afer_0525 2.348e-138 448.0 COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4CNUJ@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I MMS1_k127_2542586_5 504728.K649_14710 9.413e-102 344.0 COG0446@1|root,COG0446@2|Bacteria 2|Bacteria Q pyridine nucleotide-disulphide oxidoreductase sqr GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS1_k127_2542586_16 1385521.N803_00695 7.447e-28 122.0 COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4FG0J@85021|Intrasporangiaceae 201174|Actinobacteria T protein tyrosine phosphatase - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - Y_phosphatase3 MMS1_k127_2542586_8 414996.IL38_17585 1.143e-91 307.0 COG0778@1|root,COG0778@2|Bacteria,2I2R7@201174|Actinobacteria,408G4@622450|Actinopolysporales 201174|Actinobacteria C Nitroreductase family bluB - 1.13.11.79 ko:K04719 ko00740,ko01100,map00740,map01100 - R09083 RC00435,RC02413 ko00000,ko00001,ko01000 - - - Nitroreductase MMS1_k127_2542586_10 1150864.MILUP08_40326 6.915e-71 251.0 COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria,4D8H9@85008|Micromonosporales 201174|Actinobacteria P ABC-type Fe3 -hydroxamate transport system, periplasmic component yvrC - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 MMS1_k127_2542586_6 390989.JOEG01000009_gene1046 1.632e-99 336.0 COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4D9B0@85008|Micromonosporales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD MMS1_k127_2542586_9 1122611.KB903988_gene7143 3.405e-73 257.0 COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria,4EHGV@85012|Streptosporangiales 201174|Actinobacteria HP ATPases associated with a variety of cellular activities - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran MMS1_k127_2542586_11 525909.Afer_0804 7.832e-71 244.0 COG2109@1|root,COG2109@2|Bacteria,2GNJQ@201174|Actinobacteria,4CN3K@84992|Acidimicrobiia 84992|Acidimicrobiia H ATP:corrinoid adenosyltransferase BtuR/CobO/CobP cobO - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR MMS1_k127_2542586_13 1394178.AWOO02000023_gene5435 1.031e-51 191.0 COG1865@1|root,COG1865@2|Bacteria,2I8C5@201174|Actinobacteria,4EIHZ@85012|Streptosporangiales 201174|Actinobacteria S Adenosylcobinamide amidohydrolase - - - - - - - - - - - - CbiZ MMS1_k127_2542586_15 1169152.AXVD01000014_gene1509 1.408e-32 133.0 COG2087@1|root,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4FYZ7@85025|Nocardiaceae 201174|Actinobacteria H Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU,DBI_PRT MMS1_k127_2542586_17 1123251.ATWM01000001_gene882 1.838e-25 115.0 COG0368@1|root,COG0368@2|Bacteria,2GKM4@201174|Actinobacteria,4FGPB@85021|Intrasporangiaceae 201174|Actinobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS MMS1_k127_2542586_12 1122622.ATWJ01000002_gene838 3.765e-70 248.0 COG1270@1|root,COG1270@2|Bacteria,2GMB8@201174|Actinobacteria,4FEC6@85021|Intrasporangiaceae 201174|Actinobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib MMS1_k127_2542586_7 1123251.ATWM01000001_gene894 1.271e-95 322.0 COG0079@1|root,COG0079@2|Bacteria,2I2ND@201174|Actinobacteria,4FG89@85021|Intrasporangiaceae 201174|Actinobacteria E Aminotransferase class I and II cobC GO:0008150,GO:0040007 2.6.1.9,4.1.1.81 ko:K00817,ko:K04720 ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243,R06530 RC00006,RC00517,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2,CbiG_C MMS1_k127_2542586_4 649831.L083_1437 2.253e-114 381.0 COG2038@1|root,COG2038@2|Bacteria,2GJ16@201174|Actinobacteria,4D9TI@85008|Micromonosporales 201174|Actinobacteria H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT - 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - CobU,DBI_PRT,Nitroreductase MMS1_k127_2542586_1 469371.Tbis_2446 1.364e-163 534.0 COG1492@1|root,COG1492@2|Bacteria,2GJ1W@201174|Actinobacteria,4DYZN@85010|Pseudonocardiales 201174|Actinobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA,GATase_3 MMS1_k127_2542586_18 675635.Psed_1956 1.013e-14 88.0 COG4114@1|root,COG4114@2|Bacteria,2HNE0@201174|Actinobacteria,4E6WT@85010|Pseudonocardiales 201174|Actinobacteria S FhuF 2Fe-2S C-terminal domain - - - - - - - - - - - - FhuF,FhuF_C MMS1_k127_2542586_3 1283299.AUKG01000002_gene4178 2.908e-130 431.0 COG1797@1|root,COG1797@2|Bacteria,2GJ3R@201174|Actinobacteria,4CPJ6@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source - - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 MMS1_k127_2542586_0 105420.BBPO01000035_gene445 2.341e-164 529.0 COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,2NHHM@228398|Streptacidiphilus 201174|Actinobacteria E Pyridoxal-dependent decarboxylase, C-terminal sheet domain - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC MMS1_k127_2542586_14 1283287.KB822577_gene3147 7.344e-51 191.0 COG1279@1|root,COG1279@2|Bacteria,2IHQ2@201174|Actinobacteria,4DQJE@85009|Propionibacteriales 201174|Actinobacteria S LysE type translocator lysE GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015174,GO:0015181,GO:0015318,GO:0015711,GO:0015802,GO:0015807,GO:0015809,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902023,GO:1903825,GO:1903826,GO:1905039,GO:1990822 - ko:K06895 - - - - ko00000,ko02000 2.A.75.1 - - LysE MMS1_k127_2542669_2 525909.Afer_0525 2.01e-140 454.0 COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4CNUJ@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I MMS1_k127_2542669_3 504728.K649_14710 4.636e-102 346.0 COG0446@1|root,COG0446@2|Bacteria 2|Bacteria Q pyridine nucleotide-disulphide oxidoreductase sqr GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0005515,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0042802,GO:0044237,GO:0045333,GO:0055114 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS1_k127_2542669_6 105420.BBPO01000031_gene6633 1.674e-60 222.0 COG0614@1|root,COG0614@2|Bacteria,2I2MI@201174|Actinobacteria,2NK3T@228398|Streptacidiphilus 201174|Actinobacteria P Periplasmic binding protein yvrC - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 MMS1_k127_2542669_4 390989.JOEG01000009_gene1046 6.244e-94 319.0 COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4D9B0@85008|Micromonosporales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD MMS1_k127_2542669_7 1449353.JQMQ01000005_gene5454 3.815e-53 198.0 COG1120@1|root,COG1120@2|Bacteria,2IA4F@201174|Actinobacteria,2NK96@228398|Streptacidiphilus 201174|Actinobacteria HP ATPases associated with a variety of cellular activities - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran MMS1_k127_2542669_1 105420.BBPO01000035_gene445 8.172e-168 536.0 COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,2NHHM@228398|Streptacidiphilus 201174|Actinobacteria E Pyridoxal-dependent decarboxylase, C-terminal sheet domain - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC MMS1_k127_2542669_5 369723.Strop_1612 9.126e-78 266.0 COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4DIG7@85008|Micromonosporales 201174|Actinobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 MMS1_k127_2542669_8 196162.Noca_3037 4.604e-39 156.0 COG2920@1|root,COG2920@2|Bacteria,2IQB2@201174|Actinobacteria,4DVG7@85009|Propionibacteriales 201174|Actinobacteria P DsrC like protein - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC MMS1_k127_2542669_9 926550.CLDAP_11610 3.717e-29 130.0 COG2427@1|root,COG2427@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1641) - - - - - - - - - - - - DUF1641 MMS1_k127_2542669_0 1385519.N801_12760 1.513e-191 605.0 COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4FFV5@85021|Intrasporangiaceae 201174|Actinobacteria S Oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - DsrC,Pyr_redox_2 MMS1_k127_2542669_10 926550.CLDAP_11630 2.584e-21 104.0 COG2452@1|root,COG4936@1|root,COG2452@2|Bacteria,COG4936@2|Bacteria 2|Bacteria KT Sensory domain found in PocR - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HTH_17,PocR MMS1_k127_2542669_11 1379270.AUXF01000003_gene3543 2.337e-10 62.0 COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C MMS1_k127_2554441_65 1089549.AZUQ01000001_gene2196 1.864e-46 172.0 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria 201174|Actinobacteria L Transposase tnpA - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 MMS1_k127_2554441_16 479431.Namu_3900 2.166e-149 488.0 COG3039@1|root,COG3039@2|Bacteria,2HW75@201174|Actinobacteria,4EWBZ@85013|Frankiales 201174|Actinobacteria L PFAM transposase IS4 family protein - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 MMS1_k127_2554441_85 1121933.AUHH01000043_gene3562 4.225e-30 121.0 COG2963@1|root,COG2963@2|Bacteria,2IHPH@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 MMS1_k127_2554441_21 525368.HMPREF0591_0185 5.848e-131 428.0 COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,239TB@1762|Mycobacteriaceae 201174|Actinobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 MMS1_k127_2554441_80 1101188.KI912155_gene2940 8.353e-35 141.0 2DZKR@1|root,32VDB@2|Bacteria,2IH7Q@201174|Actinobacteria,1WBK8@1268|Micrococcaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2554441_97 1229780.BN381_390007 7.582e-22 104.0 2C22B@1|root,32R9N@2|Bacteria,2GY6A@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - HTH_17 MMS1_k127_2554441_81 710685.MycrhN_3667 2.432e-32 131.0 COG0346@1|root,COG0346@2|Bacteria,2GMTB@201174|Actinobacteria,23A96@1762|Mycobacteriaceae 201174|Actinobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - - MMS1_k127_2554441_6 164757.Mjls_3497 5.576e-233 739.0 COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,232Y7@1762|Mycobacteriaceae 201174|Actinobacteria G hydrolase - GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015927,GO:0016020,GO:0016052,GO:0016787,GO:0016798,GO:0042301,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0071704,GO:0071944,GO:1901575 - - - - - - - - - - Glyco_hydro_15 MMS1_k127_2554441_14 37919.EP51_03800 1.882e-162 529.0 COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4G0AP@85025|Nocardiaceae 201174|Actinobacteria G Glycosyltransferase family 20 otsA - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase MMS1_k127_2554441_43 479432.Sros_3221 1.509e-81 282.0 COG0647@1|root,COG0647@2|Bacteria,2GJG6@201174|Actinobacteria,4EHYG@85012|Streptosporangiales 201174|Actinobacteria G Haloacid dehalogenase-like hydrolase nagD - - ko:K02566 - - - - ko00000 - - - Hydrolase_6,Hydrolase_like MMS1_k127_2554441_32 1381123.AYOD01000042_gene2132 4.131e-107 364.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,43HVG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Sulfatase pehA - - - - - - - - - - - DUF4976,Sulfatase MMS1_k127_2554441_114 479434.Sthe_0683 0.000148 51.0 COG1011@1|root,COG1011@2|Bacteria,2G74Q@200795|Chloroflexi 200795|Chloroflexi S DinB superfamily - - - - - - - - - - - - DinB_2 MMS1_k127_2554441_46 529884.Rhola_00002620 5.285e-72 253.0 COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4FKTG@85023|Microbacteriaceae 201174|Actinobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA MMS1_k127_2554441_44 1120949.KB903299_gene6036 8.155e-80 278.0 COG4152@1|root,COG4152@2|Bacteria,2I2DK@201174|Actinobacteria,4D9AT@85008|Micromonosporales 201174|Actinobacteria S ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 MMS1_k127_2554441_72 1120934.KB894410_gene6977 2.435e-44 178.0 COG1668@1|root,COG1668@2|Bacteria,2I9MY@201174|Actinobacteria,4DYBQ@85010|Pseudonocardiales 201174|Actinobacteria CP ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 MMS1_k127_2554441_41 706587.Desti_5374 5.614e-82 282.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,43DP2@68525|delta/epsilon subdivisions,2X261@28221|Deltaproteobacteria,2MRR5@213462|Syntrophobacterales 28221|Deltaproteobacteria C NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 MMS1_k127_2554441_84 1317118.ATO8_18445 3.665e-30 136.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2TQJY@28211|Alphaproteobacteria,4KK4Y@93682|Roseivivax 28211|Alphaproteobacteria G Hydroxypyruvate reductase ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL MMS1_k127_2554441_77 697329.Rumal_0257 7.215e-36 144.0 COG0546@1|root,COG0546@2|Bacteria,1V1FQ@1239|Firmicutes,24G1U@186801|Clostridia,3WITI@541000|Ruminococcaceae 186801|Clostridia S Psort location Cytoplasmic, score nt5e - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 MMS1_k127_2554441_15 1229780.BN381_410026 6.249e-159 514.0 COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,3UWN8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases - - 1.1.2.3,1.1.99.31 ko:K00101,ko:K15054 ko00620,ko00627,ko01100,ko01120,map00620,map00627,map01100,map01120 - R00196,R04160,R07664 RC00044,RC00240 ko00000,ko00001,ko01000 - - - FMN_dh MMS1_k127_2554441_34 1122138.AQUZ01000101_gene8428 3.947e-103 348.0 COG2271@1|root,COG2271@2|Bacteria,2IEW6@201174|Actinobacteria,4DT82@85009|Propionibacteriales 201174|Actinobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2554441_99 1120950.KB892819_gene7151 1.842e-21 100.0 COG1413@1|root,COG1413@2|Bacteria,2IRUS@201174|Actinobacteria,4DSKF@85009|Propionibacteriales 201174|Actinobacteria C HEAT repeats - - - - - - - - - - - - HEAT,HEAT_2 MMS1_k127_2554441_75 1121019.AUMN01000009_gene1938 2.441e-37 146.0 COG3981@1|root,COG3981@2|Bacteria,2IGK9@201174|Actinobacteria,1W9TW@1268|Micrococcaceae 201174|Actinobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 MMS1_k127_2554441_112 1944.JOAZ01000008_gene1106 4.862e-07 60.0 2F2DM@1|root,33VBA@2|Bacteria,2HHW0@201174|Actinobacteria,418WG@629295|Streptomyces griseus group 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2554441_76 1313172.YM304_36270 8.272e-37 148.0 COG3022@1|root,COG3022@2|Bacteria,2GJPM@201174|Actinobacteria 201174|Actinobacteria S Belongs to the UPF0246 family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 - ko:K09861 - - - - ko00000 - - - H2O2_YaaD MMS1_k127_2554441_113 1267005.KB911259_gene4031 0.00012 49.0 2BH9T@1|root,32BB9@2|Bacteria,1PXUM@1224|Proteobacteria,2UH9D@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS1_k127_2554441_40 1229203.KI301992_gene1305 9.471e-86 300.0 COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,3UWPY@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr MMS1_k127_2554441_67 318424.EU78_16345 3.829e-46 174.0 COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,234I4@1762|Mycobacteriaceae 201174|Actinobacteria F glutamine amidotransferase - - - - - - - - - - - - GATase MMS1_k127_2554441_100 479435.Kfla_1781 9.921e-19 88.0 2CAFG@1|root,32ZDZ@2|Bacteria,2I800@201174|Actinobacteria,4DRHQ@85009|Propionibacteriales 201174|Actinobacteria S Protein of unknown function (DUF3039) - - - - - - - - - - - - DUF3039 MMS1_k127_2554441_95 235985.BBPN01000031_gene2153 1.557e-22 104.0 COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,2NJQ5@228398|Streptacidiphilus 201174|Actinobacteria K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg MMS1_k127_2554441_22 287986.DV20_23095 6.753e-131 429.0 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4DYUC@85010|Pseudonocardiales 201174|Actinobacteria C PFAM CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 MMS1_k127_2554441_9 1121877.JQKF01000010_gene730 2.755e-182 581.0 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4CNGH@84992|Acidimicrobiia 84992|Acidimicrobiia C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_2554441_18 1229780.BN381_170034 4.264e-143 471.0 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,3UWFB@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C MMS1_k127_2554441_26 1229780.BN381_170035 8.077e-123 409.0 COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria 201174|Actinobacteria C FAD linked - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 MMS1_k127_2554441_29 1229780.BN381_170037 4.604e-114 385.0 COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,3UWF2@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate - - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N MMS1_k127_2554441_49 37919.EP51_14230 8.135e-71 256.0 COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4FUNN@85025|Nocardiaceae 201174|Actinobacteria S Protein involved in disulfide oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, FAD binding and electron transport - - - - - - - - - - - - Pyr_redox_2,Reductase_C MMS1_k127_2554441_37 1229780.BN381_100013 2.568e-90 307.0 COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,3UXE8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B MMS1_k127_2554441_60 1313172.YM304_37370 1.374e-51 199.0 COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4CNA1@84992|Acidimicrobiia 84992|Acidimicrobiia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 MMS1_k127_2554441_105 104623.Ser39006_00915 1.332e-11 75.0 2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS1_k127_2554441_13 1386089.N865_18405 1.006e-162 530.0 COG1132@1|root,COG1132@2|Bacteria,2GJAP@201174|Actinobacteria,4FF0Q@85021|Intrasporangiaceae 201174|Actinobacteria V ABC transporter - - - - - - - - - - - - ABC_membrane,ABC_tran MMS1_k127_2554441_8 1380370.JIBA01000016_gene776 1.882e-182 590.0 COG1132@1|root,COG1132@2|Bacteria,2GJ8B@201174|Actinobacteria,4FEWF@85021|Intrasporangiaceae 201174|Actinobacteria V Multidrug ABC transporter ATPase - - - - - - - - - - - - ABC_membrane,ABC_tran MMS1_k127_2554441_55 1445613.JALM01000024_gene4363 5.629e-62 234.0 COG2251@1|root,COG2251@2|Bacteria,2HF5B@201174|Actinobacteria,4E083@85010|Pseudonocardiales 201174|Actinobacteria S TIGRFAM RecB family nuclease - - - - - - - - - - - - RNase_H_2 MMS1_k127_2554441_92 1122939.ATUD01000003_gene3463 1.541e-24 108.0 COG0589@1|root,COG0589@2|Bacteria,2GSJK@201174|Actinobacteria,4CSRN@84995|Rubrobacteria 84995|Rubrobacteria T PFAM UspA - - - - - - - - - - - - Usp MMS1_k127_2554441_83 1123322.KB904669_gene3539 3.244e-30 136.0 COG4987@1|root,COG4988@1|root,COG4987@2|Bacteria,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria 201174|Actinobacteria V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD cydD - - ko:K16013,ko:K16014 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran MMS1_k127_2554441_91 68199.JNZO01000027_gene6021 5.869e-25 121.0 COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2554441_19 404589.Anae109_2886 2.221e-134 436.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YZRV@29|Myxococcales 28221|Deltaproteobacteria C Aldo/keto reductase family - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red MMS1_k127_2554441_78 1123024.AUII01000028_gene2518 1.466e-35 144.0 COG0406@1|root,COG0406@2|Bacteria,2HRP2@201174|Actinobacteria,4EAZ6@85010|Pseudonocardiales 201174|Actinobacteria G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 MMS1_k127_2554441_94 1454010.JEOE01000002_gene487 6.049e-23 107.0 COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4F15G@85016|Cellulomonadaceae 201174|Actinobacteria S C4-type zinc ribbon domain - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K07164 - - - - ko00000 - - - zf-RING_7 MMS1_k127_2554441_102 1442599.JAAN01000024_gene1876 4.44e-17 88.0 COG1051@1|root,COG1051@2|Bacteria,1NA5A@1224|Proteobacteria,1SFGB@1236|Gammaproteobacteria,1X6B0@135614|Xanthomonadales 135614|Xanthomonadales F Nudix hydrolase - - - - - - - - - - - - NUDIX MMS1_k127_2554441_73 1120999.JONM01000015_gene2895 4.284e-43 165.0 COG3467@1|root,COG3467@2|Bacteria,1MWQE@1224|Proteobacteria,2VJNR@28216|Betaproteobacteria 28216|Betaproteobacteria C Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 MMS1_k127_2554441_69 1382356.JQMP01000001_gene1220 2.865e-45 176.0 COG0384@1|root,COG0384@2|Bacteria,2G7U6@200795|Chloroflexi,27ZAQ@189775|Thermomicrobia 189775|Thermomicrobia S Phenazine biosynthesis-like protein - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF MMS1_k127_2554441_101 649831.L083_5331 3.695e-17 91.0 COG3568@1|root,COG3568@2|Bacteria 2|Bacteria N Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Exo_endo_phos MMS1_k127_2554441_115 1095769.CAHF01000023_gene473 0.0002221 53.0 COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2VH75@28216|Betaproteobacteria 28216|Betaproteobacteria EGP major facilitator superfamily - - - ko:K08196 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,Sugar_tr MMS1_k127_2554441_53 436229.JOEH01000030_gene4834 6.025e-64 225.0 COG0053@1|root,COG0053@2|Bacteria,2IFJP@201174|Actinobacteria,2NNE9@228398|Streptacidiphilus 201174|Actinobacteria P Cation efflux family - - - - - - - - - - - - Cation_efflux MMS1_k127_2554441_27 196162.Noca_1430 6.991e-117 388.0 COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4DNSX@85009|Propionibacteriales 201174|Actinobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM MMS1_k127_2554441_82 1380354.JIAN01000005_gene1926 1.255e-31 126.0 COG0393@1|root,COG0393@2|Bacteria,2IHTU@201174|Actinobacteria,4F2PF@85016|Cellulomonadaceae 201174|Actinobacteria S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 MMS1_k127_2554441_20 1123251.ATWM01000005_gene1540 6.861e-133 445.0 COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2GNP7@201174|Actinobacteria,4FE8J@85021|Intrasporangiaceae 201174|Actinobacteria I acetyl-CoA carboxylase accA - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA,Carboxyl_trans MMS1_k127_2554441_89 36809.MAB_3376 9.095e-27 117.0 COG3832@1|root,COG3832@2|Bacteria,2IHTJ@201174|Actinobacteria,238SK@1762|Mycobacteriaceae 201174|Actinobacteria S Activator of Hsp90 ATPase - - - - - - - - - - - - AHSA1 MMS1_k127_2554441_42 1306174.JODP01000002_gene5494 1.278e-81 273.0 COG3558@1|root,COG3558@2|Bacteria,2IFFG@201174|Actinobacteria 201174|Actinobacteria K protein conserved in bacteria - - - ko:K09958 - - - - ko00000 - - - DUF1348 MMS1_k127_2554441_59 1500301.JQMF01000008_gene918 4.62e-52 191.0 COG1309@1|root,COG1309@2|Bacteria,1RDIP@1224|Proteobacteria,2U7DV@28211|Alphaproteobacteria,4BC5Q@82115|Rhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_2554441_93 1123024.AUII01000003_gene3347 8.174e-24 113.0 COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4E2RA@85010|Pseudonocardiales 201174|Actinobacteria S CHAD - - - - - - - - - - - - CHAD,CYTH MMS1_k127_2554441_79 1229780.BN381_330121 5.305e-35 143.0 COG0483@1|root,COG0483@2|Bacteria 2|Bacteria G inositol monophosphate 1-phosphatase activity - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P MMS1_k127_2554441_45 525909.Afer_1580 1.129e-78 267.0 2CGIK@1|root,33UPP@2|Bacteria,2H4PB@201174|Actinobacteria,4CN1M@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2554441_110 1111131.HMPREF1255_0030 1.187e-07 65.0 COG1652@1|root,COG3170@1|root,COG1652@2|Bacteria,COG3170@2|Bacteria,2GWK7@201174|Actinobacteria,4DP6W@85009|Propionibacteriales 201174|Actinobacteria NU LysM domain - - - - - - - - - - - - LysM MMS1_k127_2554441_31 525909.Afer_0599 2.713e-111 370.0 COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4CN7S@84992|Acidimicrobiia 84992|Acidimicrobiia F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N MMS1_k127_2554441_35 525909.Afer_0598 1.166e-102 354.0 COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4CN8B@84992|Acidimicrobiia 84992|Acidimicrobiia M Mur ligase family, glutamate ligase domain murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M MMS1_k127_2554441_70 408672.NBCG_02084 5.58e-45 172.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity acoC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Biotin_lipoyl,E3_binding MMS1_k127_2554441_51 1229780.BN381_10320 1.4e-67 256.0 COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,3UW87@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L UvrD-like helicase C-terminal domain uvrD2 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - HRDC,UvrD-helicase,UvrD_C MMS1_k127_2554441_17 1123023.JIAI01000001_gene6257 5.141e-147 479.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4E1ZB@85010|Pseudonocardiales 201174|Actinobacteria C FAD linked oxidases, C-terminal domain - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 MMS1_k127_2554441_23 1306990.BARG01000062_gene7078 4.517e-130 435.0 COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria 201174|Actinobacteria EH Belongs to the TPP enzyme family ilvX GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0019752,GO:0030312,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N MMS1_k127_2554441_38 1313172.YM304_23330 1.142e-88 300.0 COG0708@1|root,COG0708@2|Bacteria,2GKEW@201174|Actinobacteria,4CN0I@84992|Acidimicrobiia 84992|Acidimicrobiia L Endonuclease/Exonuclease/phosphatase family xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos MMS1_k127_2554441_63 525909.Afer_1728 1.413e-49 180.0 COG0764@1|root,COG0764@2|Bacteria,2GQWT@201174|Actinobacteria,4CN5K@84992|Acidimicrobiia 84992|Acidimicrobiia I FabA-like domain fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA MMS1_k127_2554441_62 1229780.BN381_10314 2.815e-50 196.0 COG0539@1|root,COG0539@2|Bacteria,2I7V9@201174|Actinobacteria 201174|Actinobacteria J Zc3h12a-like Ribonuclease NYN domain - - - - - - - - - - - - HC2,RNase_Zc3h12a MMS1_k127_2554441_1 1313172.YM304_23290 0.0 1292.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CMWS@84992|Acidimicrobiia 84992|Acidimicrobiia C 2-oxoglutarate dehydrogenase N-terminus - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr MMS1_k127_2554441_88 1283283.ATXA01000010_gene4499 8.83e-28 123.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 MMS1_k127_2554441_52 67275.JOAP01000067_gene3740 2.762e-66 241.0 COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria 201174|Actinobacteria S epimerase - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase MMS1_k127_2554441_28 1121877.JQKF01000005_gene903 5.959e-115 392.0 COG0747@1|root,COG0747@2|Bacteria,2GZTR@201174|Actinobacteria,4CNEY@84992|Acidimicrobiia 201174|Actinobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS1_k127_2554441_48 525909.Afer_1142 2.286e-71 254.0 COG0601@1|root,COG0601@2|Bacteria,2GK0Z@201174|Actinobacteria,4CNGS@84992|Acidimicrobiia 84992|Acidimicrobiia U Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS1_k127_2554441_50 525909.Afer_1143 4.56e-70 248.0 COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4CN2T@84992|Acidimicrobiia 84992|Acidimicrobiia U N-terminal TM domain of oligopeptide transport permease C - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N MMS1_k127_2554441_4 105420.BBPO01000058_gene3543 1.456e-243 769.0 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,2NFTX@228398|Streptacidiphilus 201174|Actinobacteria P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS1_k127_2554441_64 1043493.BBLU01000010_gene211 9.528e-48 178.0 COG0164@1|root,COG0164@2|Bacteria,2GJFN@201174|Actinobacteria 201174|Actinobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII MMS1_k127_2554441_96 1229780.BN381_80155 3.776e-22 104.0 COG1920@1|root,COG1920@2|Bacteria 2|Bacteria S nucleotidyltransferase activity cofC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CofC,NTP_transf_3 MMS1_k127_2554441_54 1121877.JQKF01000037_gene1811 1.251e-62 233.0 COG3505@1|root,COG3505@2|Bacteria,2GNQ7@201174|Actinobacteria,4CNHM@84992|Acidimicrobiia 84992|Acidimicrobiia U TraM recognition site of TraD and TraG - - - - - - - - - - - - - MMS1_k127_2554441_111 450380.JPSY01000004_gene2913 3.207e-07 62.0 COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria,4FKPJ@85023|Microbacteriaceae 201174|Actinobacteria L TrwC relaxase - - - - - - - - - - - - AAA_30,TrwC MMS1_k127_2554441_104 1035308.AQYY01000001_gene3035 6.446e-14 85.0 COG2378@1|root,COG2378@2|Bacteria 2|Bacteria K regulation of single-species biofilm formation pafC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K13573 - - - - ko00000,ko03051 - - - WYL MMS1_k127_2554441_106 1050202.KB913024_gene1177 1.533e-10 74.0 COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,407J9@622450|Actinopolysporales 201174|Actinobacteria K WYL domain pafB GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K13572,ko:K13573 - - - - ko00000,ko03051 - - - WYL MMS1_k127_2554441_66 1229780.BN381_90063 3.704e-46 171.0 COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,3UXES@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H MoaC family moaC GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0008150,GO:0009605,GO:0009607,GO:0031347,GO:0031348,GO:0035821,GO:0040007,GO:0043207,GO:0044003,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0075136,GO:0080134 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoaC MMS1_k127_2554441_98 1214101.BN159_5081 1.532e-21 98.0 COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria 201174|Actinobacteria S Regulatory protein, FmdB family - - - - - - - - - - - - Zn-ribbon_8 MMS1_k127_2554441_24 1313172.YM304_10900 1.157e-125 421.0 COG0312@1|root,COG0312@2|Bacteria,2HGNU@201174|Actinobacteria,4CNQT@84992|Acidimicrobiia 84992|Acidimicrobiia S Putative modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD MMS1_k127_2554441_11 1313172.YM304_10890 8.792e-178 568.0 COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4CNKK@84992|Acidimicrobiia 84992|Acidimicrobiia S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD MMS1_k127_2554441_7 525909.Afer_0479 1.533e-215 686.0 COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4CMS4@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C MMS1_k127_2554441_68 1107311.Q767_15515 2.597e-45 172.0 COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,1I20A@117743|Flavobacteriia,2NWFD@237|Flavobacterium 976|Bacteroidetes O Peptide-methionine (R)-S-oxide reductase msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR MMS1_k127_2554441_86 1463917.JODC01000002_gene836 1.412e-29 124.0 COG1247@1|root,COG1247@2|Bacteria,2IHU7@201174|Actinobacteria 201174|Actinobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 MMS1_k127_2554441_56 525909.Afer_1760 2.012e-57 211.0 COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CN4Q@84992|Acidimicrobiia 84992|Acidimicrobiia D Part of the ABC transporter FtsEX involved in cellular division ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - MMS1_k127_2554441_36 525909.Afer_1761 7.38e-101 335.0 COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CMPM@84992|Acidimicrobiia 84992|Acidimicrobiia D ATPases associated with a variety of cellular activities ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran MMS1_k127_2554441_25 525909.Afer_1762 1.496e-125 414.0 COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4CMPD@84992|Acidimicrobiia 84992|Acidimicrobiia J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 MMS1_k127_2554441_2 1121877.JQKF01000008_gene670 0.0 1090.0 COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4CMVS@84992|Acidimicrobiia 84992|Acidimicrobiia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW MMS1_k127_2554441_71 106370.Francci3_0736 1.579e-44 174.0 COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4ERBZ@85013|Frankiales 201174|Actinobacteria S PFAM Glycosyl transferase family 2 wbbL GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576 2.4.1.289 ko:K16870 - - - - ko00000,ko01000,ko01003 - - iNJ661.Rv3265c Glyco_tranf_2_3,Glycos_transf_2 MMS1_k127_2554441_58 1313172.YM304_28700 2.225e-54 205.0 COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4CN33@84992|Acidimicrobiia 84992|Acidimicrobiia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose - - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind MMS1_k127_2554441_74 469371.Tbis_0702 9.132e-39 154.0 COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4E356@85010|Pseudonocardiales 201174|Actinobacteria H biotin lipoate A B protein ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB MMS1_k127_2554441_3 525909.Afer_0730 2.428e-246 773.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4CMS3@84992|Acidimicrobiia 84992|Acidimicrobiia I Biotin carboxylase C-terminal domain - - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 MMS1_k127_2554441_30 1089546.AQUI01000002_gene3065 3.215e-112 374.0 COG1473@1|root,COG1473@2|Bacteria,2GNEG@201174|Actinobacteria,407FU@622450|Actinopolysporales 201174|Actinobacteria S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 MMS1_k127_2554441_103 1177594.MIC448_2130014 2.768e-15 89.0 COG2329@1|root,COG2329@2|Bacteria,2IQWX@201174|Actinobacteria,4FQ4M@85023|Microbacteriaceae 201174|Actinobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM MMS1_k127_2554441_5 1121877.JQKF01000001_gene1345 3.157e-239 749.0 COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CMX5@84992|Acidimicrobiia 84992|Acidimicrobiia I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase MMS1_k127_2554441_109 1122138.AQUZ01000013_gene5640 3.839e-09 64.0 COG1714@1|root,COG1714@2|Bacteria,2HGSH@201174|Actinobacteria,4DSGU@85009|Propionibacteriales 201174|Actinobacteria S RDD family pra GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - RDD MMS1_k127_2554441_10 525909.Afer_0728 3.526e-180 571.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4CMRS@84992|Acidimicrobiia 84992|Acidimicrobiia HP ThiF family - - - - - - - - - - - - Rhodanese,ThiF MMS1_k127_2554441_90 1121877.JQKF01000001_gene1347 1.467e-25 118.0 COG0778@1|root,COG0778@2|Bacteria,2GW57@201174|Actinobacteria,4CN7W@84992|Acidimicrobiia 84992|Acidimicrobiia C Nitroreductase family - - - - - - - - - - - - Nitroreductase MMS1_k127_2554441_39 1122622.ATWJ01000009_gene3236 1.952e-88 310.0 COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4FEMJ@85021|Intrasporangiaceae 201174|Actinobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N MMS1_k127_2554441_61 1229780.BN381_80027 3.131e-51 188.0 COG2096@1|root,COG2096@2|Bacteria,2GMHN@201174|Actinobacteria,3UWVY@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Cobalamin adenosyltransferase yvqK - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans MMS1_k127_2554441_0 525909.Afer_0723 0.0 1416.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4CN9K@84992|Acidimicrobiia 84992|Acidimicrobiia H B12 binding domain - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans MMS1_k127_2554441_108 28444.JODQ01000008_gene1019 4.355e-10 70.0 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein - - - - - - - - - - - - Collagen,DUF2479 MMS1_k127_2554441_12 525909.Afer_0719 4.888e-166 537.0 COG0320@1|root,COG0321@1|root,COG0320@2|Bacteria,COG0321@2|Bacteria,2GKD4@201174|Actinobacteria,4CMR4@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,LIAS_N,Radical_SAM MMS1_k127_2554441_57 1229780.BN381_210108 3.076e-57 214.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,3UWBR@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes - - 2.3.1.168,2.3.1.61 ko:K00658,ko:K09699 ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00036 R02570,R02571,R02662,R03174,R04097,R08549,R10998 RC00004,RC02727,RC02833,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS1_k127_2554441_33 1122622.ATWJ01000014_gene392 2.109e-103 352.0 COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria,4FGVY@85021|Intrasporangiaceae 201174|Actinobacteria L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom MMS1_k127_2554441_47 446466.Cfla_0617 9.511e-72 252.0 2AYN7@1|root,31QSQ@2|Bacteria,2IQ18@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2555419_23 1121924.ATWH01000005_gene2709 6.168e-07 54.0 COG1396@1|root,COG1396@2|Bacteria,2HVFF@201174|Actinobacteria,4FT95@85023|Microbacteriaceae 201174|Actinobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 MMS1_k127_2555419_21 1032480.MLP_33090 5.3e-31 124.0 COG3550@1|root,COG3550@2|Bacteria,2IH7C@201174|Actinobacteria,4DWV0@85009|Propionibacteriales 201174|Actinobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C MMS1_k127_2555419_8 1048339.KB913029_gene4509 1.018e-117 392.0 COG2895@1|root,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4ERC4@85013|Frankiales 201174|Actinobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysC GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU MMS1_k127_2555419_5 164757.Mjls_0376 6.715e-129 418.0 COG0175@1|root,COG0175@2|Bacteria,2GN85@201174|Actinobacteria,235PV@1762|Mycobacteriaceae 201174|Actinobacteria EH Phosphoadenosine phosphosulfate reductase family - - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct MMS1_k127_2555419_16 710687.KI912270_gene6317 9.025e-53 194.0 COG0175@1|root,COG0175@2|Bacteria,2GJ3Z@201174|Actinobacteria,2345B@1762|Mycobacteriaceae 201174|Actinobacteria EH Belongs to the PAPS reductase family. CysH subfamily cysH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004604,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016667,GO:0016671,GO:0019344,GO:0019752,GO:0040007,GO:0043436,GO:0043866,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2392 PAPS_reduct MMS1_k127_2555419_24 35725.K2RRF1 0.000138 54.0 COG0738@1|root,2QQA7@2759|Eukaryota,38HCE@33154|Opisthokonta,3NWFM@4751|Fungi,3QM7W@4890|Ascomycota,200E1@147541|Dothideomycetes 4751|Fungi G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2555419_20 888052.HMPREF9006_1779 1.253e-31 136.0 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4D35P@85005|Actinomycetales 201174|Actinobacteria GK ROK family ppgK - 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK MMS1_k127_2555419_18 313612.L8106_12540 1.753e-42 169.0 COG0449@1|root,COG0449@2|Bacteria,1FZVQ@1117|Cyanobacteria,1H73S@1150|Oscillatoriales 2|Bacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmD - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - SIS MMS1_k127_2555419_1 105425.BBPL01000003_gene6808 2.068e-177 573.0 COG0747@1|root,COG0747@2|Bacteria,2GNKN@201174|Actinobacteria,2NFI0@228398|Streptacidiphilus 201174|Actinobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS1_k127_2555419_4 1380347.JNII01000005_gene3565 3.943e-131 425.0 COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria 201174|Actinobacteria EP PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 MMS1_k127_2555419_12 1463820.JOGW01000008_gene1444 1.989e-100 335.0 COG1173@1|root,COG1173@2|Bacteria,2IBS7@201174|Actinobacteria 201174|Actinobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N MMS1_k127_2555419_6 479433.Caci_1181 4.122e-124 406.0 COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria 201174|Actinobacteria EP Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS1_k127_2555419_7 1120954.ATXE01000001_gene2105 2.204e-118 389.0 COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DTSN@85009|Propionibacteriales 201174|Actinobacteria E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS1_k127_2555419_9 1120950.KB892775_gene1173 2.047e-116 392.0 COG3525@1|root,COG3525@2|Bacteria,2H28J@201174|Actinobacteria,4DN2G@85009|Propionibacteriales 201174|Actinobacteria G Glycosyl hydrolase family 20, catalytic domain - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - Glyco_hydro_20,Glyco_hydro_20b MMS1_k127_2555419_19 1120950.KB892761_gene5824 5.195e-36 149.0 2BVX8@1|root,30QZQ@2|Bacteria,2GZ2G@201174|Actinobacteria,4DUP1@85009|Propionibacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2555419_14 926550.CLDAP_27090 4.42e-58 211.0 COG1349@1|root,COG1349@2|Bacteria,2G8GY@200795|Chloroflexi 200795|Chloroflexi K Helix-turn-helix type 11 domain protein - - - ko:K02081 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR MMS1_k127_2555419_10 1122238.AULR01000013_gene2356 1.017e-105 349.0 COG0434@1|root,COG0434@2|Bacteria,2I8ZY@201174|Actinobacteria 201174|Actinobacteria S PFAM photosystem I assembly BtpA sgcQ - - ko:K06971 - - - - ko00000 - - - BtpA MMS1_k127_2555419_2 350054.Mflv_3774 1.431e-158 515.0 COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,2363K@1762|Mycobacteriaceae 201174|Actinobacteria G Belongs to the FGGY kinase family xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N MMS1_k127_2555419_13 1209984.BN978_07034 4.348e-92 309.0 COG1028@1|root,COG1028@2|Bacteria,2GNM4@201174|Actinobacteria,232DJ@1762|Mycobacteriaceae 201174|Actinobacteria IQ reductase - - - - - - - - - - - - adh_short_C2 MMS1_k127_2555419_3 1429046.RR21198_4332 7.852e-137 448.0 COG1064@1|root,COG1064@2|Bacteria,2GKNW@201174|Actinobacteria,4FX4J@85025|Nocardiaceae 201174|Actinobacteria P alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS1_k127_2555419_15 1123368.AUIS01000006_gene572 1.015e-56 206.0 COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,1RSBH@1236|Gammaproteobacteria,2NCEE@225057|Acidithiobacillales 225057|Acidithiobacillales S SOS response associated peptidase (SRAP) - - - - - - - - - - - - SRAP MMS1_k127_2555419_17 58123.JOFJ01000014_gene5097 1.266e-49 194.0 COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria 201174|Actinobacteria L Nucleotidyltransferase DNA polymerase involved in DNA repair dinB_2 - - ko:K14161 - - - - ko00000,ko03400 - - - IMS MMS1_k127_2555419_0 263358.VAB18032_26911 0.0 1112.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4D8EW@85008|Micromonosporales 201174|Actinobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon MMS1_k127_2555419_11 1283283.ATXA01000021_gene2882 9.825e-101 337.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ES16@85013|Frankiales 201174|Actinobacteria V TIGRFAM daunorubicin resistance ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 MMS1_k127_2558338_5 469371.Tbis_1732 2.814e-46 179.0 COG2186@1|root,COG2186@2|Bacteria,2IAQ9@201174|Actinobacteria,4E5KH@85010|Pseudonocardiales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - dCache_1 MMS1_k127_2558338_4 469371.Tbis_1733 1.132e-71 250.0 COG2186@1|root,COG2186@2|Bacteria,2GKJM@201174|Actinobacteria,4E348@85010|Pseudonocardiales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - FCD,GntR MMS1_k127_2558338_7 90813.JQMT01000001_gene1089 8.72e-05 50.0 COG3450@1|root,COG3450@2|Bacteria,1N8CD@1224|Proteobacteria,1SAR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF861) - - - ko:K06995 - - - - ko00000 - - - Cupin_3 MMS1_k127_2558338_3 1226994.AMZB01000114_gene2240 1.984e-85 298.0 COG2334@1|root,COG2334@2|Bacteria,1R4QR@1224|Proteobacteria,1SMU2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH MMS1_k127_2558338_2 1306174.JODP01000005_gene1325 8.009e-131 439.0 COG1457@1|root,COG1457@2|Bacteria 2|Bacteria F cytosine transport cytX - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur MMS1_k127_2558338_1 1003195.SCAT_1018 2.799e-142 468.0 COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria 201174|Actinobacteria S modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD MMS1_k127_2558338_0 44060.JODL01000028_gene5124 3.158e-201 637.0 COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria 201174|Actinobacteria S Modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD MMS1_k127_2558338_6 1035308.AQYY01000001_gene2493 1.091e-05 48.0 COG1433@1|root,COG1433@2|Bacteria 2|Bacteria S nitrogen fixation - - - - - - - - - - - - Nitro_FeMo-Co MMS1_k127_2560962_8 1121918.ARWE01000001_gene3108 7.939e-72 251.0 COG0580@1|root,COG0580@2|Bacteria,1MZ47@1224|Proteobacteria 1224|Proteobacteria U Belongs to the MIP aquaporin (TC 1.A.8) family - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP MMS1_k127_2560962_6 1463861.JNXE01000009_gene6907 9.441e-80 275.0 COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase MMS1_k127_2560962_10 1209984.BN978_03323 8.888e-60 230.0 COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,232VN@1762|Mycobacteriaceae 201174|Actinobacteria I esterase lipO - - - - - - - - - - - Abhydrolase_3 MMS1_k127_2560962_0 1380356.JNIK01000001_gene2179 0.0 1067.0 COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4ERSS@85013|Frankiales 201174|Actinobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 MMS1_k127_2560962_4 525909.Afer_0306 3.464e-118 396.0 COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4CMTW@84992|Acidimicrobiia 84992|Acidimicrobiia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e MMS1_k127_2560962_19 1121087.AUCK01000009_gene2133 7.701e-22 96.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,1ZHSU@1386|Bacillus 91061|Bacilli K Cold shock cspB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD MMS1_k127_2560962_1 1121877.JQKF01000016_gene124 8.813e-196 616.0 COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4CMRQ@84992|Acidimicrobiia 84992|Acidimicrobiia C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_2560962_20 1089549.AZUQ01000001_gene761 1.667e-16 91.0 COG0406@1|root,COG0406@2|Bacteria,2IRT2@201174|Actinobacteria,4F0B3@85014|Glycomycetales 201174|Actinobacteria G Histidine phosphatase superfamily (branch 1) - - - - - - - - - - - - His_Phos_1 MMS1_k127_2560962_14 419947.MRA_1057 4.438e-28 126.0 COG4861@1|root,COG4861@2|Bacteria,2H1DQ@201174|Actinobacteria 201174|Actinobacteria S Protein conserved in bacteria - - - - - - - - - - - - AbiEi_2 MMS1_k127_2560962_15 1348338.ADILRU_0107 3.999e-26 118.0 28HCU@1|root,2Z7PM@2|Bacteria,2GPHN@201174|Actinobacteria,4FSAB@85023|Microbacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2560962_23 1172188.KB911826_gene163 1.608e-05 50.0 COG1960@1|root,COG1960@2|Bacteria,2GNTA@201174|Actinobacteria,4FIDQ@85021|Intrasporangiaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_2560962_7 1348663.KCH_38650 6.375e-77 267.0 COG0583@1|root,COG0583@2|Bacteria,2GMES@201174|Actinobacteria,2M15X@2063|Kitasatospora 201174|Actinobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate MMS1_k127_2560962_5 675635.Psed_5192 1.49e-86 299.0 COG2855@1|root,COG2855@2|Bacteria,2GS6E@201174|Actinobacteria,4E1GI@85010|Pseudonocardiales 201174|Actinobacteria S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 MMS1_k127_2560962_21 1150399.AQYK01000002_gene3223 7.173e-10 67.0 COG0394@1|root,COG0394@2|Bacteria,2GMPR@201174|Actinobacteria,4FPK5@85023|Microbacteriaceae 201174|Actinobacteria T Low molecular weight phosphatase family etp - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc MMS1_k127_2560962_13 1313172.YM304_09550 2.166e-29 124.0 COG1309@1|root,COG1309@2|Bacteria,2HGBF@201174|Actinobacteria,4CNA8@84992|Acidimicrobiia 84992|Acidimicrobiia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_2560962_16 670487.Ocepr_1770 5.268e-26 120.0 COG0438@1|root,COG0438@2|Bacteria,1WIYM@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 MMS1_k127_2560962_2 326427.Cagg_2084 2.808e-158 503.0 COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi,375CR@32061|Chloroflexia 32061|Chloroflexia M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd MMS1_k127_2560962_11 1229780.BN381_310049 1.064e-36 147.0 COG1131@1|root,COG1131@2|Bacteria,2IRXJ@201174|Actinobacteria 201174|Actinobacteria V Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran MMS1_k127_2560962_12 1229780.BN381_310050 4.101e-30 128.0 COG2386@1|root,COG2386@2|Bacteria,2GUCP@201174|Actinobacteria 201174|Actinobacteria O heme exporter protein CcmB - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB MMS1_k127_2560962_9 1121877.JQKF01000016_gene155 5.14e-64 241.0 COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CN1E@84992|Acidimicrobiia 84992|Acidimicrobiia O Cytochrome C assembly protein - - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm MMS1_k127_2560962_17 1121877.JQKF01000016_gene157 1.325e-25 112.0 COG2332@1|root,COG2332@2|Bacteria,2GZPB@201174|Actinobacteria,4CNCV@84992|Acidimicrobiia 84992|Acidimicrobiia O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE MMS1_k127_2560962_3 1229780.BN381_310054 5.7e-156 520.0 COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria 201174|Actinobacteria O Cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm MMS1_k127_2560962_18 709986.Deima_1148 6.497e-23 104.0 COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus CO periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily - - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA MMS1_k127_2560962_22 1216966.BAUC01000021_gene1132 3.136e-08 64.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9H1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P subunit of a heme lyase nrfF GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0022607,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0065003,GO:0071704,GO:0071840,GO:1901564 - ko:K02200,ko:K04017 - - - - ko00000 - - - CcmH MMS1_k127_2622804_34 1120948.KB903229_gene5133 3.97e-06 49.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,4E0GX@85010|Pseudonocardiales 201174|Actinobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C MMS1_k127_2622804_6 56780.SYN_01903 1.36e-117 389.0 COG2152@1|root,COG2152@2|Bacteria,1MX8M@1224|Proteobacteria,42Z2Q@68525|delta/epsilon subdivisions,2WTK0@28221|Deltaproteobacteria,2MR59@213462|Syntrophobacterales 28221|Deltaproteobacteria G beta-1,4-mannooligosaccharide phosphorylase - - - - - - - - - - - - Glyco_hydro_130 MMS1_k127_2622804_17 1449048.JQKU01000008_gene1132 4.984e-68 248.0 COG0438@1|root,COG0438@2|Bacteria,2I97T@201174|Actinobacteria,235R1@1762|Mycobacteriaceae 201174|Actinobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - MMS1_k127_2622804_10 479433.Caci_7428 4.324e-95 325.0 COG0438@1|root,COG0438@2|Bacteria,2GNPG@201174|Actinobacteria 201174|Actinobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 MMS1_k127_2622804_22 351607.Acel_0039 7.489e-42 158.0 COG2764@1|root,COG2764@2|Bacteria,2IKY5@201174|Actinobacteria,4ET8M@85013|Frankiales 201174|Actinobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt MMS1_k127_2622804_31 543632.JOJL01000067_gene1393 1.095e-17 96.0 2B8ZY@1|root,322AK@2|Bacteria,2H6NN@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2622804_11 1380390.JIAT01000009_gene1049 1.153e-92 314.0 COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4CQ7M@84995|Rubrobacteria 84995|Rubrobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2622804_16 1283283.ATXA01000013_gene3448 6.935e-72 253.0 COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria,4ESH4@85013|Frankiales 201174|Actinobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core MMS1_k127_2622804_15 35754.JNYJ01000065_gene5711 2.242e-74 266.0 COG2307@1|root,COG2307@2|Bacteria,2GN0T@201174|Actinobacteria,4DC5X@85008|Micromonosporales 201174|Actinobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E MMS1_k127_2622804_1 35754.JNYJ01000065_gene5710 3.688e-196 624.0 COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,4DARU@85008|Micromonosporales 201174|Actinobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2 MMS1_k127_2622804_14 1380347.JNII01000008_gene4396 2.323e-79 268.0 COG1695@1|root,COG1695@2|Bacteria,2GNA1@201174|Actinobacteria,4EV4N@85013|Frankiales 201174|Actinobacteria K PFAM transcriptional regulator PadR family protein - - - - - - - - - - - - PadR MMS1_k127_2622804_9 1894.JOER01000014_gene5695 2.778e-100 332.0 COG1136@1|root,COG1136@2|Bacteria,2GM25@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2622804_2 1380356.JNIK01000018_gene606 1.633e-176 579.0 COG0577@1|root,COG0577@2|Bacteria,2GKF3@201174|Actinobacteria,4ETTR@85013|Frankiales 201174|Actinobacteria V FtsX-like permease family - - - - - - - - - - - - FtsX MMS1_k127_2622804_25 1313172.YM304_02170 2.125e-35 145.0 COG1716@1|root,COG1716@2|Bacteria,2HG8X@201174|Actinobacteria,4CN6T@84992|Acidimicrobiia 84992|Acidimicrobiia T Protein of unknown function (DUF2662) - - - - - - - - - - - - DUF3662,FHA MMS1_k127_2622804_28 1229780.BN381_70016 4.44e-21 98.0 COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,3UWWG@52018|unclassified Actinobacteria (class) 201174|Actinobacteria T Forkhead associated domain fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - - - - - - - - - - FHA,Yop-YscD_cpl MMS1_k127_2622804_20 1229780.BN381_70017 3.705e-57 215.0 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,3UWNU@52018|unclassified Actinobacteria (class) 201174|Actinobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K01090,ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 MMS1_k127_2622804_8 1121877.JQKF01000011_gene361 3.396e-114 389.0 COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4CMY4@84992|Acidimicrobiia 84992|Acidimicrobiia M Penicillin binding protein transpeptidase domain - - - ko:K05364 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01011 - - - Transpeptidase MMS1_k127_2622804_5 1121877.JQKF01000011_gene362 1.785e-127 430.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CMUZ@84992|Acidimicrobiia 84992|Acidimicrobiia KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase MMS1_k127_2622804_3 1313172.YM304_01060 7.122e-169 540.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTJ@84992|Acidimicrobiia 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N MMS1_k127_2622804_23 1211815.CBYP010000067_gene112 9.552e-41 156.0 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity - - - - - - - - - - - - 4HBT MMS1_k127_2622804_4 390989.JOEG01000014_gene3137 2.784e-141 454.0 COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4D9FR@85008|Micromonosporales 201174|Actinobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C MMS1_k127_2622804_29 1313172.YM304_14800 1.086e-20 100.0 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity - - - - - - - - - - - - 4HBT MMS1_k127_2622804_0 1206741.BAFX01000099_gene1042 3.103e-202 638.0 COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria,4FV1I@85025|Nocardiaceae 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.55 ko:K15372 ko00410,ko00430,ko01100,map00410,map00430,map01100 - R00908,R01684 RC00006,RC00062 ko00000,ko00001,ko01000 - - - Aminotran_3 MMS1_k127_2622804_32 882086.SacxiDRAFT_1682 5.525e-09 67.0 2E5RJ@1|root,330G5@2|Bacteria,2GQFX@201174|Actinobacteria,4E4VB@85010|Pseudonocardiales 201174|Actinobacteria S Protein of unknown function (DUF4232) - - - - - - - - - - - - DUF4232 MMS1_k127_2622804_7 436229.JOEH01000019_gene6668 1.155e-116 398.0 COG0477@1|root,COG0477@2|Bacteria,2IBIG@201174|Actinobacteria,2NHKA@228398|Streptacidiphilus 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_2622804_35 1437603.BMON_1304 2.134e-05 54.0 2E5RJ@1|root,330G5@2|Bacteria,2GQFX@201174|Actinobacteria,4D16M@85004|Bifidobacteriales 201174|Actinobacteria S Protein of unknown function (DUF4232) - - - - - - - - - - - - DUF4232 MMS1_k127_2622804_21 1121272.KB903290_gene4658 2.62e-47 181.0 COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4DCGZ@85008|Micromonosporales 201174|Actinobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 MMS1_k127_2622804_12 316274.Haur_4579 2.022e-89 304.0 COG1131@1|root,COG1131@2|Bacteria,2G5QI@200795|Chloroflexi,376R4@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS1_k127_2622804_30 263358.VAB18032_13455 7.506e-20 96.0 COG2320@1|root,COG2320@2|Bacteria,2GTS4@201174|Actinobacteria,4DEZ5@85008|Micromonosporales 201174|Actinobacteria S GrpB protein - - - - - - - - - - - - GrpB MMS1_k127_2622804_13 1121946.AUAX01000011_gene4110 5.876e-83 279.0 COG1335@1|root,COG1335@2|Bacteria,2IG6Q@201174|Actinobacteria,4DCVB@85008|Micromonosporales 201174|Actinobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase MMS1_k127_2622804_27 105422.BBPM01000060_gene4272 1.214e-24 111.0 COG0454@1|root,COG0454@2|Bacteria,2I32C@201174|Actinobacteria,2NJ1R@228398|Streptacidiphilus 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 MMS1_k127_2622804_24 1121362.A605_06975 3.05e-37 155.0 COG1672@1|root,COG1672@2|Bacteria,2GWBV@201174|Actinobacteria,22JUR@1653|Corynebacteriaceae 201174|Actinobacteria S ATPase (AAA superfamily) - - - - - - - - - - - - AAA_16 MMS1_k127_2622804_18 1146883.BLASA_5011 2.947e-65 228.0 COG0286@1|root,COG0286@2|Bacteria,2GP6Y@201174|Actinobacteria 201174|Actinobacteria V N-6 DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase MMS1_k127_2622804_26 243232.MJ_ECL33 1.541e-25 119.0 arCOG06586@1|root,arCOG06586@2157|Archaea,2Y1JI@28890|Euryarchaeota 28890|Euryarchaeota - - - - - - - - - - - - - - - MMS1_k127_2622804_19 1122609.AUGT01000005_gene1828 2.953e-61 234.0 2BIFQ@1|root,32CNA@2|Bacteria,2IN70@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_2622804_33 698964.CDPW8_1636 1.052e-06 62.0 COG0582@1|root,COG0582@2|Bacteria,2GV6D@201174|Actinobacteria,22NPX@1653|Corynebacteriaceae 201174|Actinobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase MMS1_k127_2692278_2 351607.Acel_2099 6.68e-117 390.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,2IIRA@201174|Actinobacteria,4ESMY@85013|Frankiales 201174|Actinobacteria T PFAM EAL domain - - - - - - - - - - - - EAL,GAF_2,PAS,PAS_3,Response_reg MMS1_k127_2692278_0 1048339.KB913029_gene700 1.152e-148 494.0 COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4ESNT@85013|Frankiales 201174|Actinobacteria T Response regulator receiver - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,Response_reg MMS1_k127_2692278_1 1206730.BAGA01000172_gene2205 1.213e-134 439.0 COG4584@1|root,COG4584@2|Bacteria,2HKD7@201174|Actinobacteria,4G0R7@85025|Nocardiaceae 201174|Actinobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_7,rve MMS1_k127_2692278_6 1451261.AS96_14800 8.284e-07 57.0 COG4584@1|root,COG4584@2|Bacteria,2HKD7@201174|Actinobacteria,4FRTK@85023|Microbacteriaceae 201174|Actinobacteria L Integrase core domain - - - - - - - - - - - - HTH_7,rve MMS1_k127_2692278_5 110319.CF8_0933 2.023e-92 308.0 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DTYI@85009|Propionibacteriales 201174|Actinobacteria L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21,UPF0114 MMS1_k127_2692278_3 253839.SSNG_07182 3.191e-107 364.0 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria 201174|Actinobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 MMS1_k127_2692278_4 68194.JNXR01000074_gene1753 1.224e-100 335.0 COG4584@1|root,COG4584@2|Bacteria,2GM4J@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - rve MMS1_k127_2746183_41 196162.Noca_3275 1.133e-20 95.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4DV63@85009|Propionibacteriales 201174|Actinobacteria L Helix-turn-helix domain - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon MMS1_k127_2746183_40 1121877.JQKF01000016_gene147 3.154e-22 98.0 2FBA6@1|root,343GA@2|Bacteria,2H78Y@201174|Actinobacteria,4CN8Z@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_2746183_38 1313172.YM304_07660 4.446e-25 106.0 2CC1Y@1|root,32TCV@2|Bacteria,2HGD4@201174|Actinobacteria,4CNAQ@84992|Acidimicrobiia 84992|Acidimicrobiia K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA - - - ko:K18955 - - - - ko00000,ko03000 - - - Whib MMS1_k127_2746183_31 525909.Afer_0329 1.62e-51 194.0 COG3643@1|root,COG3643@2|Bacteria,2H8ZI@201174|Actinobacteria,4CNR1@84992|Acidimicrobiia 84992|Acidimicrobiia E Formiminotransferase domain, N-terminal subdomain - - 2.1.2.5 ko:K00603 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R03189 RC00165,RC00221,RC00223,RC00870 ko00000,ko00001,ko01000 - - - FTCD_N MMS1_k127_2746183_34 1229780.BN381_130084 5.323e-38 145.0 2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,3UWSD@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whmD - - ko:K18955 - - - - ko00000,ko03000 - - - Whib MMS1_k127_2746183_12 1313172.YM304_07620 1.92e-135 456.0 COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4CMU5@84992|Acidimicrobiia 84992|Acidimicrobiia S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - MMS1_k127_2746183_7 1313172.YM304_07520 5.023e-160 526.0 COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4CMSG@84992|Acidimicrobiia 84992|Acidimicrobiia H Mg-chelatase subunit ChlI - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - - MMS1_k127_2746183_13 640132.Srot_2486 1.517e-130 428.0 COG1228@1|root,COG1228@2|Bacteria,2GJH4@201174|Actinobacteria 201174|Actinobacteria Q Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 MMS1_k127_2746183_0 1306174.JODP01000001_gene5283 7.535e-303 934.0 COG2987@1|root,COG2987@2|Bacteria,2GP10@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N MMS1_k127_2746183_4 1246474.ANBE01000061_gene1031 2.767e-193 616.0 COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria,4EFM8@85012|Streptosporangiales 201174|Actinobacteria E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic MMS1_k127_2746183_23 1416759.AYMR01000024_gene2569 3.5e-74 259.0 COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria,4FKS9@85023|Microbacteriaceae 201174|Actinobacteria E Arginase family - - 3.5.3.11,3.5.3.8 ko:K01479,ko:K01480 ko00330,ko00340,ko01100,map00330,map00340,map01100 M00045,M00133 R01157,R02285 RC00024,RC00221,RC00329,RC00681 ko00000,ko00001,ko00002,ko01000 - - - Arginase MMS1_k127_2746183_39 1121877.JQKF01000037_gene1809 1.853e-23 112.0 29BBV@1|root,2ZCHD@2|Bacteria,2I82W@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - NAGPA MMS1_k127_2746183_6 1121877.JQKF01000003_gene1555 5.82e-166 546.0 COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4CN9T@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome b/b6/petB - - - ko:K03891 ko00190,ko01100,map00190,map01100 M00151 - - ko00000,ko00001,ko00002 - - - Cytochrom_B_N_2 MMS1_k127_2746183_19 525909.Afer_1826 1.658e-93 318.0 COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4CNF9@84992|Acidimicrobiia 84992|Acidimicrobiia C Rieske [2Fe-2S] domain - - - ko:K03890 ko00190,ko01100,map00190,map01100 M00151 - - ko00000,ko00001,ko00002 - - - Rieske MMS1_k127_2746183_26 525909.Afer_1827 7.337e-66 236.0 COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4CNJZ@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K03889 ko00190,ko01100,map00190,map01100 M00151 - - ko00000,ko00001,ko00002 - - - Cytochrome_CBB3 MMS1_k127_2746183_25 525909.Afer_1828 2.512e-66 232.0 COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4CNAV@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome c oxidase subunit III - - 1.9.3.1 ko:K02276,ko:K02299 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.5,3.D.4.6 - - COX3 MMS1_k127_2746183_8 1229780.BN381_100026 1.614e-159 530.0 COG3973@1|root,COG3973@2|Bacteria,2GK30@201174|Actinobacteria,3UX0X@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L DNA helicase helD - - - - - - - - - - - AAA_19,UvrD-helicase,UvrD_C_2,Viral_helicase1 MMS1_k127_2746183_15 1229780.BN381_100025 5.782e-126 417.0 COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,3UWFA@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D MMS1_k127_2746183_22 1382304.JNIL01000001_gene1030 3.539e-82 284.0 COG0276@1|root,COG0276@2|Bacteria,1TPKF@1239|Firmicutes,4HAYG@91061|Bacilli 91061|Bacilli H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase MMS1_k127_2746183_24 1449347.JQLN01000003_gene5746 9.393e-69 256.0 COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,2M1SM@2063|Kitasatospora 201174|Actinobacteria H Flavin containing amine oxidoreductase hemG - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase MMS1_k127_2746183_42 1476876.JOJO01000042_gene8155 9.952e-17 87.0 COG5083@1|root,COG5083@2|Bacteria,2IFC7@201174|Actinobacteria 201174|Actinobacteria S phosphatidylinositol transporter activity - - - - - - - - - - - - Acid_phosphat_B MMS1_k127_2746183_11 35754.JNYJ01000011_gene731 1.117e-146 503.0 COG2898@1|root,COG2898@2|Bacteria,2I2ZR@201174|Actinobacteria,4DBVQ@85008|Micromonosporales 201174|Actinobacteria S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3,6.1.1.6 ko:K04567,ko:K14205 ko00970,ko01503,ko02020,ko05150,map00970,map01503,map02020,map05150 M00359,M00360,M00726 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko01504,ko03016 2.A.1.3.37 - - DUF2156,tRNA-synt_2_TM MMS1_k127_2746183_37 426117.M446_2966 2.62e-29 131.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2TWW6@28211|Alphaproteobacteria,1JSEN@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF MMS1_k127_2746183_29 471857.Svir_16060 2.348e-59 217.0 COG0189@1|root,COG0189@2|Bacteria,2HI2Z@201174|Actinobacteria,4DXM1@85010|Pseudonocardiales 201174|Actinobacteria HJ ligase activity dcsG - - - - - - - - - - - - MMS1_k127_2746183_18 1121877.JQKF01000009_gene570 1.252e-112 380.0 COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M MMS1_k127_2746183_16 1229780.BN381_160013 6.872e-121 409.0 COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,3UWBE@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology nuoM - 1.6.5.3 ko:K00342,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M MMS1_k127_2746183_5 1121877.JQKF01000009_gene572 1.564e-190 613.0 COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4CMPU@84992|Acidimicrobiia 84992|Acidimicrobiia CP protein synonym multiple resistance and pH homeostasis protein A - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N MMS1_k127_2746183_35 1121877.JQKF01000009_gene573 1.608e-37 143.0 COG0713@1|root,COG0713@2|Bacteria,2IKV7@201174|Actinobacteria,4CN4N@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 MMS1_k127_2746183_36 1121877.JQKF01000009_gene574 2.232e-37 152.0 COG0839@1|root,COG0839@2|Bacteria,2GKRS@201174|Actinobacteria,4CN8Y@84992|Acidimicrobiia 84992|Acidimicrobiia C NADH-ubiquinone/plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 MMS1_k127_2746183_20 525909.Afer_0371 8.443e-93 310.0 COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 MMS1_k127_2746183_10 525909.Afer_0370 3.263e-151 493.0 COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4CMTV@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh MMS1_k127_2746183_2 1229780.BN381_160007 1.957e-199 651.0 COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,3UWBF@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 MMS1_k127_2746183_3 525909.Afer_0368 6.685e-198 625.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4CMQ2@84992|Acidimicrobiia 84992|Acidimicrobiia C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S MMS1_k127_2746183_27 525909.Afer_0367 5.372e-62 220.0 COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4CN1U@84992|Acidimicrobiia 84992|Acidimicrobiia C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx MMS1_k127_2746183_1 1121877.JQKF01000009_gene580 2.244e-202 640.0 COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa MMS1_k127_2746183_30 1313172.YM304_04080 4.852e-54 194.0 COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4CN4G@84992|Acidimicrobiia 84992|Acidimicrobiia C Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa MMS1_k127_2746183_21 525909.Afer_0364 3.607e-86 287.0 COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4CMXA@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 MMS1_k127_2746183_33 525909.Afer_0363 1.34e-39 152.0 COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4CN51@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 MMS1_k127_2746183_17 1229780.BN381_450016 9.209e-121 401.0 COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,3UX9K@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C FAD binding domain menJ GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016491,GO:0016627,GO:0030312,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 1.3.99.38 ko:K21401 - - - - ko00000,ko01000 - - - FAD_binding_3 MMS1_k127_2746183_28 1382306.JNIM01000001_gene2642 3.254e-61 220.0 COG0672@1|root,COG0672@2|Bacteria 2|Bacteria P high-affinity ferrous iron transmembrane transporter activity efeU GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1,Peptidase_M75 MMS1_k127_2746183_32 1214101.BN159_5530 3.086e-43 175.0 COG1670@1|root,COG1670@2|Bacteria,2I90W@201174|Actinobacteria 201174|Actinobacteria J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - Acetyltransf_3 MMS1_k127_2746183_9 1229780.BN381_60036 3.157e-151 492.0 COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,3UW7J@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Glutamate-1-semialdehyde aminotransferase hemL GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 MMS1_k127_2746183_14 1313172.YM304_37800 4.864e-129 421.0 COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4CMV9@84992|Acidimicrobiia 84992|Acidimicrobiia H Delta-aminolevulinic acid dehydratase hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD MMS1_k127_2746183_43 262724.TT_C1143 1.694e-05 53.0 COG1587@1|root,COG1587@2|Bacteria,1WJ3C@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Uroporphyrinogen-III synthase HemD - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 MMS1_k127_2750472_6 67373.JOBF01000036_gene4725 1.65e-76 270.0 COG0477@1|root,COG0477@2|Bacteria,2I2QX@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,TRI12 MMS1_k127_2750472_2 1123024.AUII01000044_gene601 1.184e-138 454.0 COG1063@1|root,COG1063@2|Bacteria,2GKFG@201174|Actinobacteria,4E0X4@85010|Pseudonocardiales 201174|Actinobacteria E Glucose dehydrogenase C-terminus - - - - - - - - - - - - ADH_N,Glu_dehyd_C MMS1_k127_2750472_1 446468.Ndas_1406 8.907e-232 736.0 COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4EGGJ@85012|Streptosporangiales 201174|Actinobacteria G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 MMS1_k127_2750472_13 443598.AUFA01000004_gene5523 1.835e-48 177.0 COG0454@1|root,COG0454@2|Bacteria,1QTZ4@1224|Proteobacteria,2U7E4@28211|Alphaproteobacteria,3JV2E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K FR47-like protein MA20_02285 - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 MMS1_k127_2750472_10 266117.Rxyl_0187 8.174e-71 250.0 COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4CQ94@84995|Rubrobacteria 84995|Rubrobacteria K response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C MMS1_k127_2750472_14 926564.KI911738_gene3231 3.852e-48 191.0 COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4F41U@85017|Promicromonosporaceae 201174|Actinobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA MMS1_k127_2750472_5 103733.JNYO01000004_gene7400 3.686e-95 332.0 COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4DXCQ@85010|Pseudonocardiales 201174|Actinobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N MMS1_k127_2750472_4 234267.Acid_0085 6.734e-105 364.0 COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria 57723|Acidobacteria V ABC transporter transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran MMS1_k127_2750472_12 1210046.B277_13894 1.366e-50 200.0 COG0438@1|root,COG0438@2|Bacteria,2ID3T@201174|Actinobacteria,4FGBI@85021|Intrasporangiaceae 201174|Actinobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 MMS1_k127_2750472_11 349163.Acry_0205 7.966e-64 245.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,2JQVA@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS1_k127_2750472_8 1408418.JNJH01000061_gene1196 2.425e-75 280.0 COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,2TSTV@28211|Alphaproteobacteria,2JRG0@204441|Rhodospirillales 204441|Rhodospirillales S Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C MMS1_k127_2750472_7 582515.KR51_00017720 4.056e-76 273.0 COG0451@1|root,COG0451@2|Bacteria,1G0GJ@1117|Cyanobacteria 1117|Cyanobacteria M PFAM NAD dependent epimerase dehydratase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd MMS1_k127_2750472_15 1001240.GY21_02885 1.906e-44 165.0 COG3832@1|root,COG3832@2|Bacteria,2IPH4@201174|Actinobacteria,4FPVG@85023|Microbacteriaceae 201174|Actinobacteria S Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red,Polyketide_cyc2 MMS1_k127_2750472_17 191610.CATYP_10130 3.956e-08 64.0 COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,22JK2@1653|Corynebacteriaceae 201174|Actinobacteria T universal stress protein uspA1 - - - - - - - - - - - Usp MMS1_k127_2750472_0 314345.SPV1_00345 2.053e-250 801.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria 1224|Proteobacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 MMS1_k127_2750472_9 208444.JNYY01000004_gene2076 1.352e-72 259.0 COG2755@1|root,COG2755@2|Bacteria,2GYQF@201174|Actinobacteria 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 MMS1_k127_2750472_3 882082.SaccyDRAFT_3131 7.19e-127 424.0 2CE4Q@1|root,2Z7WX@2|Bacteria,2H0P6@201174|Actinobacteria,4E993@85010|Pseudonocardiales 201174|Actinobacteria S Arylsulfotransferase (ASST) - - - - - - - - - - - - Arylsulfotran_2 MMS1_k127_28359_6 1120950.KB892790_gene2051 1.478e-123 406.0 COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2GYM5@201174|Actinobacteria,4DSZ1@85009|Propionibacteriales 201174|Actinobacteria C Nickel-dependent hydrogenase hycE - - - - - - - - - - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases MMS1_k127_28359_12 1380356.JNIK01000005_gene1082 6.686e-39 152.0 COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4ESPH@85013|Frankiales 201174|Actinobacteria L Belongs to the DNA glycosylase MPG family alkA GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco MMS1_k127_28359_5 1396418.BATQ01000184_gene2632 8.199e-126 438.0 COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia 74201|Verrucomicrobia T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc,NB-ARC MMS1_k127_28359_9 562970.Btus_1398 8.094e-75 266.0 COG1940@1|root,COG1940@2|Bacteria,1TQU4@1239|Firmicutes,4HA1C@91061|Bacilli 91061|Bacilli GK Fructokinase gmuE - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - ROK MMS1_k127_28359_13 35754.JNYJ01000039_gene10005 7.907e-37 147.0 COG0563@1|root,COG0563@2|Bacteria,2IGX9@201174|Actinobacteria,4DM6N@85008|Micromonosporales 201174|Actinobacteria F Shikimate kinase - - - - - - - - - - - - AAA,AAA_33,SKI MMS1_k127_28359_4 298654.FraEuI1c_6009 2.123e-148 498.0 COG3266@1|root,COG3266@2|Bacteria,2I302@201174|Actinobacteria 201174|Actinobacteria S response to copper ion - - - - - - - - - - - - - MMS1_k127_28359_7 1122138.AQUZ01000010_gene5154 7.34e-115 387.0 COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4DQQR@85009|Propionibacteriales 201174|Actinobacteria E Aminotransferase class I and II metC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 MMS1_k127_28359_3 710111.FraQA3DRAFT_0914 1.971e-148 475.0 COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4ETQ1@85013|Frankiales 201174|Actinobacteria C PFAM aldo keto reductase - - 1.1.1.91 ko:K05882 - - - - ko00000,ko01000 - - - Aldo_ket_red MMS1_k127_28359_0 543632.JOJL01000002_gene8381 1.323e-170 549.0 COG0477@1|root,COG0477@2|Bacteria,2IBIG@201174|Actinobacteria,4DCAI@85008|Micromonosporales 201174|Actinobacteria EGP the major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_28359_11 469383.Cwoe_0256 1.777e-51 190.0 COG1309@1|root,COG1309@2|Bacteria,2GM0B@201174|Actinobacteria,4CSUH@84995|Rubrobacteria 84995|Rubrobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_28359_10 1169161.KB897718_gene3428 6.49e-55 201.0 COG2320@1|root,COG2320@2|Bacteria,2IFSJ@201174|Actinobacteria 201174|Actinobacteria H GrpB protein - - - - - - - - - - - - GrpB MMS1_k127_28359_8 68170.KL590503_gene163 7.856e-75 261.0 COG0745@1|root,COG0745@2|Bacteria,2GJ2N@201174|Actinobacteria,4DZ76@85010|Pseudonocardiales 201174|Actinobacteria T Member of the two-component regulatory system kdpD kdpE involved in the regulation of the kdp operon kdpE - - ko:K02483,ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_28359_2 1150864.MILUP08_40604 4.103e-154 517.0 COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria,4DBA8@85008|Micromonosporales 201174|Actinobacteria T Domain of unknown function (DUF4118) kdpD - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD,Usp MMS1_k127_28359_1 1449347.JQLN01000004_gene6475 1.513e-156 508.0 COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,2M0PM@2063|Kitasatospora 201174|Actinobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 MMS1_k127_377199_20 35754.JNYJ01000042_gene1340 9.089e-39 162.0 COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4D9VP@85008|Micromonosporales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA MMS1_k127_377199_15 1906.SFRA_16265 4.556e-53 199.0 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria 201174|Actinobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_377199_13 1276920.ADIAG_02183 3.148e-54 197.0 COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 MMS1_k127_377199_27 1108045.GORHZ_247_00420 2.392e-06 52.0 2AEQH@1|root,314M2@2|Bacteria,2GYUE@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 MMS1_k127_377199_2 1380390.JIAT01000010_gene4509 1.171e-122 415.0 COG0473@1|root,COG0473@2|Bacteria,2I4BP@201174|Actinobacteria,4CPAZ@84995|Rubrobacteria 84995|Rubrobacteria CE Isocitrate/isopropylmalate dehydrogenase - - - - - - - - - - - - Iso_dh MMS1_k127_377199_10 1229780.BN381_130166 1.126e-65 229.0 2DCZU@1|root,2ZFYS@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS1_k127_377199_1 1229780.BN381_80237 2.447e-143 467.0 COG1960@1|root,COG1960@2|Bacteria 2|Bacteria I acyl-CoA dehydrogenase activity - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_377199_4 1120950.KB892731_gene3810 1.483e-103 353.0 COG0154@1|root,COG0154@2|Bacteria,2GSDB@201174|Actinobacteria,4DPCU@85009|Propionibacteriales 201174|Actinobacteria J Amidase gatA_1 - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase MMS1_k127_377199_19 1192868.CAIU01000013_gene1664 4.859e-39 152.0 COG3981@1|root,COG3981@2|Bacteria,1RGGC@1224|Proteobacteria,2UAUM@28211|Alphaproteobacteria,43N6U@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 MMS1_k127_377199_17 1192868.CAIU01000013_gene1664 1.985e-50 188.0 COG3981@1|root,COG3981@2|Bacteria,1RGGC@1224|Proteobacteria,2UAUM@28211|Alphaproteobacteria,43N6U@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 MMS1_k127_377199_8 1229780.BN381_130028 2.809e-69 252.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,3UXFU@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Carbohydrate kinase nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N MMS1_k127_377199_7 1121946.AUAX01000019_gene7777 7.927e-70 243.0 COG3340@1|root,COG3340@2|Bacteria,2ISWE@201174|Actinobacteria 201174|Actinobacteria E Peptidase family S51 - - - - - - - - - - - - Peptidase_S51 MMS1_k127_377199_21 685035.ADAE01000008_gene3040 6.783e-35 140.0 2EQUS@1|root,33KPM@2|Bacteria,1QY6Y@1224|Proteobacteria,2URR2@28211|Alphaproteobacteria,2KEN6@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - MMS1_k127_377199_14 103733.JNYO01000004_gene7383 7.623e-54 193.0 COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4E3HZ@85010|Pseudonocardiales 201174|Actinobacteria O PFAM OsmC-like protein osmC - - ko:K04063 - - - - ko00000 - - - OsmC MMS1_k127_377199_18 1312959.KI914663_gene3624 3.454e-40 160.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - 2.7.7.65 ko:K21023 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - CHASE,EAL,GGDEF MMS1_k127_377199_24 215803.DB30_7899 1.949e-19 93.0 2DN1Z@1|root,32V20@2|Bacteria,1Q8W3@1224|Proteobacteria,43E1M@68525|delta/epsilon subdivisions,2WZFP@28221|Deltaproteobacteria,2Z21B@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - MMS1_k127_377199_11 543632.JOJL01000034_gene5129 4.29e-65 230.0 COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4DINJ@85008|Micromonosporales 201174|Actinobacteria M L,D-transpeptidase catalytic domain - - - - - - - - - - - - PG_binding_1,YkuD MMS1_k127_377199_9 351607.Acel_0891 4.427e-68 237.0 COG2128@1|root,COG2128@2|Bacteria,2HTUG@201174|Actinobacteria,4EUKU@85013|Frankiales 201174|Actinobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - - MMS1_k127_377199_6 1278078.G419_00415 7.274e-73 254.0 COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4G3H5@85025|Nocardiaceae 201174|Actinobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 MMS1_k127_377199_5 1206743.BAGM01000199_gene987 3.439e-88 306.0 COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4FXF4@85025|Nocardiaceae 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 MMS1_k127_377199_16 455632.SGR_5037 5.704e-53 193.0 COG0637@1|root,COG0637@2|Bacteria,2GMIQ@201174|Actinobacteria,419TP@629295|Streptomyces griseus group 201174|Actinobacteria S HAD-hyrolase-like - - - - - - - - - - - - HAD_2 MMS1_k127_377199_3 1137271.AZUM01000001_gene1431 1.55e-118 399.0 2CE4Q@1|root,2Z7WX@2|Bacteria,2H0P6@201174|Actinobacteria,4E993@85010|Pseudonocardiales 201174|Actinobacteria S Arylsulfotransferase (ASST) - - - - - - - - - - - - Arylsulfotran_2 MMS1_k127_377199_25 1123519.PSJM300_09960 1.105e-12 77.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,1YZUY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I COG1024 Enoyl-CoA hydratase carnithine racemase liuC - 4.2.1.18 ko:K13766 ko00280,ko01100,map00280,map01100 M00036 R02085 RC02416 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 MMS1_k127_377199_12 1206729.BAFZ01000158_gene6462 2.983e-64 231.0 COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4FVRF@85025|Nocardiaceae 201174|Actinobacteria P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese MMS1_k127_377199_22 1380356.JNIK01000021_gene4503 1.425e-33 140.0 COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4EVCN@85013|Frankiales 201174|Actinobacteria S Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB MMS1_k127_377199_0 710685.MycrhN_2535 1.311e-220 722.0 COG2274@1|root,COG2274@2|Bacteria,2GNB5@201174|Actinobacteria,238WK@1762|Mycobacteriaceae 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 MMS1_k127_41985_2 1122609.AUGT01000005_gene1828 5.312e-06 50.0 2BIFQ@1|root,32CNA@2|Bacteria,2IN70@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_41985_1 1229780.BN381_500025 7.391e-110 360.0 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria 201174|Actinobacteria L PFAM IstB domain protein ATP-binding protein istB - - - - - - - - - - - IstB_IS21 MMS1_k127_41985_0 105420.BBPO01000081_gene4430 3.956e-159 517.0 COG4584@1|root,COG4584@2|Bacteria,2GZ8H@201174|Actinobacteria,2NH43@228398|Streptacidiphilus 201174|Actinobacteria L Integrase core domain - - - - - - - - - - - - rve MMS1_k127_41985_3 1122609.AUGT01000005_gene1828 0.0001259 48.0 2BIFQ@1|root,32CNA@2|Bacteria,2IN70@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_420654_93 1121447.JONL01000022_gene3718 1.722e-11 64.0 2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria,42WB2@68525|delta/epsilon subdivisions,2WWEJ@28221|Deltaproteobacteria,2MFC3@213115|Desulfovibrionales 28221|Deltaproteobacteria S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - MMS1_k127_420654_89 1150469.RSPPHO_03258 6.613e-18 84.0 2B9ZZ@1|root,323DM@2|Bacteria,1MZ6J@1224|Proteobacteria 1224|Proteobacteria S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - MMS1_k127_420654_61 566461.SSFG_03805 1.808e-50 181.0 2AU0F@1|root,31JKB@2|Bacteria,2IT83@201174|Actinobacteria 201174|Actinobacteria S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - MMS1_k127_420654_98 1348908.KI518583_gene2324 6.724e-08 56.0 2DR8Z@1|root,33AQV@2|Bacteria,1VK7N@1239|Firmicutes,4HRWZ@91061|Bacilli,1ZISI@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - MMS1_k127_420654_30 1306174.JODP01000019_gene4612 1.462e-98 350.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF MMS1_k127_420654_26 656024.FsymDg_1452 8.214e-107 377.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales 201174|Actinobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF MMS1_k127_420654_80 446465.Bfae_25960 1.702e-34 145.0 COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4FDIR@85020|Dermabacteraceae 201174|Actinobacteria L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 MMS1_k127_420654_35 1248760.ANFZ01000006_gene2293 1.234e-86 293.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria,2K1KB@204457|Sphingomonadales 204457|Sphingomonadales H Aldolase/RraA - - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like MMS1_k127_420654_87 1229780.BN381_290093 3.852e-21 109.0 COG0457@1|root,COG0457@2|Bacteria 1229780.BN381_290093|- S peptidyl-tyrosine sulfation - - - - - - - - - - - - - MMS1_k127_420654_14 1172180.KB911792_gene3677 1.316e-164 523.0 COG1830@1|root,COG1830@2|Bacteria,2I9V1@201174|Actinobacteria 201174|Actinobacteria G PFAM deoxyribose-phosphate aldolase phospho-2- dehydro-3-deoxyheptonate aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC MMS1_k127_420654_79 590998.Celf_1930 1.173e-34 141.0 COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4F1IX@85016|Cellulomonadaceae 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA2 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf MMS1_k127_420654_67 1313172.YM304_25690 2.051e-43 163.0 COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4CN5F@84992|Acidimicrobiia 84992|Acidimicrobiia E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein - - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H MMS1_k127_420654_81 469371.Tbis_1693 1.271e-31 129.0 COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4E2ZJ@85010|Pseudonocardiales 201174|Actinobacteria T (FHA) domain garA - - - - - - - - - - - FHA,Yop-YscD_cpl,zinc_ribbon_2 MMS1_k127_420654_88 1146883.BLASA_2621 1.056e-19 100.0 COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4ESMT@85013|Frankiales 201174|Actinobacteria K PFAM regulatory protein, MerR merR1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - MerR,MerR_1 MMS1_k127_420654_77 512565.AMIS_51820 1.426e-36 144.0 COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4D9DY@85008|Micromonosporales 201174|Actinobacteria S Bifunctional nuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K08999 - - - - ko00000 - - - DNase-RNase MMS1_k127_420654_12 105420.BBPO01000002_gene7590 2.441e-182 584.0 COG0531@1|root,COG0531@2|Bacteria,2GJ1D@201174|Actinobacteria,2NGGY@228398|Streptacidiphilus 201174|Actinobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,AA_permease_2 MMS1_k127_420654_42 700508.D174_04075 1.687e-77 270.0 COG0604@1|root,COG0604@2|Bacteria,2GKYZ@201174|Actinobacteria,233HW@1762|Mycobacteriaceae 201174|Actinobacteria C Quinone oxidoreductase - - - - - - - - - - - - ADH_N,ADH_zinc_N MMS1_k127_420654_49 1283287.KB822576_gene3895 6.778e-62 222.0 COG0596@1|root,COG0596@2|Bacteria,2H1QB@201174|Actinobacteria,4DR46@85009|Propionibacteriales 201174|Actinobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 MMS1_k127_420654_58 1121877.JQKF01000100_gene2 1.576e-53 205.0 2ATXZ@1|root,31JHI@2|Bacteria,2GN21@201174|Actinobacteria,4CNNN@84992|Acidimicrobiia 84992|Acidimicrobiia S Glycosyltransferase family 87 - - - - - - - - - - - - GT87 MMS1_k127_420654_102 525909.Afer_1162 0.0007059 49.0 2B87Q@1|root,321GA@2|Bacteria,2HGVA@201174|Actinobacteria,4CNW4@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_420654_45 525909.Afer_1155 6.369e-73 256.0 COG0351@1|root,COG0351@2|Bacteria,2GKZM@201174|Actinobacteria 201174|Actinobacteria H Phosphomethylpyrimidine kinase thiD GO:0008150,GO:0040007 2.7.1.35,2.7.1.49,2.7.4.7 ko:K00868,ko:K00941 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin MMS1_k127_420654_32 391037.Sare_4277 9.144e-90 302.0 COG2022@1|root,COG2022@2|Bacteria,2GM62@201174|Actinobacteria,4D9I2@85008|Micromonosporales 201174|Actinobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0008150,GO:0040007 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG MMS1_k127_420654_76 1229780.BN381_40086 2.566e-37 145.0 COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,3UWPC@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K helix_turn_helix, mercury resistance merR2 - - - - - - - - - - - MerR_1 MMS1_k127_420654_84 671143.DAMO_2813 1.139e-28 122.0 COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria 2|Bacteria F Cytidylate kinase-like family - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Cytidylate_kin2,GAF_2,Pribosyltran MMS1_k127_420654_27 1313172.YM304_25740 2.627e-105 352.0 COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4CMQS@84992|Acidimicrobiia 84992|Acidimicrobiia H Glycine cleavage T-protein C-terminal barrel domain gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C MMS1_k127_420654_23 1121877.JQKF01000002_gene1721 9.902e-132 437.0 COG0403@1|root,COG0403@2|Bacteria,2IBH2@201174|Actinobacteria,4CNJP@84992|Acidimicrobiia 84992|Acidimicrobiia C The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P MMS1_k127_420654_8 1121877.JQKF01000002_gene1720 1.141e-200 637.0 COG1003@1|root,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria,4CMXT@84992|Acidimicrobiia 84992|Acidimicrobiia E Glycine cleavage system P-protein - - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P MMS1_k127_420654_60 1394178.AWOO02000001_gene1307 2.675e-52 194.0 COG2071@1|root,COG2071@2|Bacteria,2GIV6@201174|Actinobacteria,4EIVR@85012|Streptosporangiales 201174|Actinobacteria S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 MMS1_k127_420654_83 1380354.JIAN01000005_gene2778 4.868e-30 126.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - AhpC-TSA,MauE,Redoxin MMS1_k127_420654_91 468556.AQYG01000050_gene2977 4.454e-14 82.0 COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria,4GENB@85026|Gordoniaceae 201174|Actinobacteria U Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB MMS1_k127_420654_99 1028800.RG540_CH19060 1.072e-07 59.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria,4BESE@82115|Rhizobiaceae 28211|Alphaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB MMS1_k127_420654_29 1229780.BN381_80127 2.444e-101 335.0 COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria,3UXC4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria IQ KR domain rhlG - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 MMS1_k127_420654_39 525909.Afer_0721 3.089e-80 285.0 COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4CN3Q@84992|Acidimicrobiia 84992|Acidimicrobiia O Domain present in PSD-95, Dlg, and ZO-1/2. - - - ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 MMS1_k127_420654_53 1121877.JQKF01000002_gene1635 7.003e-60 223.0 2F1PM@1|root,33UPX@2|Bacteria,2H4R3@201174|Actinobacteria,4CN41@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_420654_97 1121877.JQKF01000002_gene1631 1.009e-08 64.0 2DDS5@1|root,2ZJ1Y@2|Bacteria,2HDMP@201174|Actinobacteria,4CP3T@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_420654_7 1313172.YM304_25950 9.092e-202 641.0 COG1351@1|root,COG1351@2|Bacteria,2HBYZ@201174|Actinobacteria,4CMUK@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - - - - - - - - - - Thy1 MMS1_k127_420654_22 561180.BIFGAL_02766 3.893e-133 458.0 COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4CZEC@85004|Bifidobacteriales 201174|Actinobacteria L DEAD DEAH box helicase helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K03727 - - - - ko00000,ko01000 - - - DEAD,DSHCT,Helicase_C,rRNA_proc-arch MMS1_k127_420654_56 1313172.YM304_25980 4.325e-56 204.0 COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CN3F@84992|Acidimicrobiia 84992|Acidimicrobiia U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC MMS1_k127_420654_68 760568.Desku_2139 1.984e-42 163.0 COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,261SF@186807|Peptococcaceae 186801|Clostridia U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 MMS1_k127_420654_11 525909.Afer_0912 7.19e-183 582.0 COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine pafA - 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase MMS1_k127_420654_40 525909.Afer_0911 1.133e-79 272.0 COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4CMY5@84992|Acidimicrobiia 84992|Acidimicrobiia O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcA - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome MMS1_k127_420654_55 471852.Tcur_2311 8.619e-57 210.0 COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4EFQB@85012|Streptosporangiales 201174|Actinobacteria O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcB - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome MMS1_k127_420654_92 671143.DAMO_0690 3.501e-13 72.0 2E9C2@1|root,30ZT9@2|Bacteria,2NRQ4@2323|unclassified Bacteria 2|Bacteria S Pup-like protein - - - ko:K13570 - - - - ko00000,ko04121 - - - Pup MMS1_k127_420654_15 525909.Afer_0908 3.451e-164 531.0 COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4CMSZ@84992|Acidimicrobiia 84992|Acidimicrobiia S Pup-ligase protein dop - 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase MMS1_k127_420654_4 525909.Afer_0907 4.272e-244 766.0 COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4CMRU@84992|Acidimicrobiia 84992|Acidimicrobiia O Proteasomal ATPase OB/ID domain arc - - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB MMS1_k127_420654_73 1121877.JQKF01000002_gene1617 2.372e-38 144.0 COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4CN8X@84992|Acidimicrobiia 84992|Acidimicrobiia C 4Fe-4S single cluster domain of Ferredoxin I - - - ko:K05337 - - - - ko00000 - - - Fer4_15 MMS1_k127_420654_37 1229780.BN381_410006 4.237e-84 290.0 COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,3UWFZ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA trmI GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14,GCD14_N MMS1_k127_420654_94 405948.SACE_1886 6.118e-10 65.0 COG2050@1|root,COG2050@2|Bacteria,2IJ48@201174|Actinobacteria,4E5BE@85010|Pseudonocardiales 201174|Actinobacteria Q Domain of unknown function (DUF4442) - - - - - - - - - - - - 4HBT MMS1_k127_420654_10 1229780.BN381_410021 2.395e-195 629.0 COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,3UW9I@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Transketolase, pyrimidine binding domain tkt GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N MMS1_k127_420654_33 926550.CLDAP_03770 5.487e-88 305.0 COG0176@1|root,COG0176@2|Bacteria,2GA93@200795|Chloroflexi 200795|Chloroflexi H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA MMS1_k127_420654_64 1229781.C272_07105 4.323e-48 190.0 COG0166@1|root,COG0166@2|Bacteria,2HYJQ@201174|Actinobacteria,4F8MB@85019|Brevibacteriaceae 201174|Actinobacteria G Phosphoglucose isomerase - - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI MMS1_k127_420654_1 1123024.AUII01000021_gene79 2.2e-293 917.0 COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DX6M@85010|Pseudonocardiales 201174|Actinobacteria H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM MMS1_k127_420654_47 1451261.AS96_10700 1.302e-62 226.0 COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4FMB4@85023|Microbacteriaceae 201174|Actinobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox MMS1_k127_420654_6 345341.KUTG_09562 9.27e-208 659.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZ4K@85010|Pseudonocardiales 201174|Actinobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C MMS1_k127_420654_19 1283283.ATXA01000001_gene752 4.843e-148 485.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4ERK8@85013|Frankiales 201174|Actinobacteria C TIGRFAM glutamate synthase, NADH NADPH, small subunit gltD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iNJ661.Rv3858c Fer4_20,Pyr_redox_2 MMS1_k127_420654_0 351607.Acel_1078 0.0 1725.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4ERS2@85013|Frankiales 201174|Actinobacteria E Glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase MMS1_k127_420654_71 479435.Kfla_2849 2.034e-40 164.0 COG0665@1|root,COG0665@2|Bacteria,2GJVR@201174|Actinobacteria,4DR72@85009|Propionibacteriales 201174|Actinobacteria C FAD dependent oxidoreductase thiO - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO MMS1_k127_420654_95 1121272.KB903250_gene2970 7.539e-10 64.0 COG2104@1|root,COG2104@2|Bacteria,2I1GU@201174|Actinobacteria,4DGH6@85008|Micromonosporales 201174|Actinobacteria H ThiS family thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS MMS1_k127_420654_17 1121877.JQKF01000001_gene1331 6.103e-151 486.0 COG1902@1|root,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4CNVA@84992|Acidimicrobiia 84992|Acidimicrobiia C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN MMS1_k127_420654_13 1449347.JQLN01000007_gene1597 7.258e-181 577.0 COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,2M0VW@2063|Kitasatospora 201174|Actinobacteria E Pfam FAD dependent oxidoreductase - - - - - - - - - - - - DAO MMS1_k127_420654_3 351607.Acel_1984 1.274e-283 885.0 COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4ERWG@85013|Frankiales 201174|Actinobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C MMS1_k127_420654_54 1089546.AQUI01000002_gene2427 1.034e-57 206.0 COG1584@1|root,COG1584@2|Bacteria,2IIIX@201174|Actinobacteria 201174|Actinobacteria S PFAM GPR1 FUN34 yaaH family - - - ko:K07034 - - - - ko00000 - - - Grp1_Fun34_YaaH MMS1_k127_420654_46 525909.Afer_1094 1.022e-63 227.0 COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4CMZW@84992|Acidimicrobiia 84992|Acidimicrobiia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA MMS1_k127_420654_16 1229780.BN381_50177 3.263e-161 519.0 COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,3UWAH@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS1_k127_420654_85 666685.R2APBS1_1347 1.189e-26 117.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1X459@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI MMS1_k127_420654_52 1313172.YM304_24270 1.503e-60 218.0 COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4CN2P@84992|Acidimicrobiia 84992|Acidimicrobiia E Indole-3-glycerol phosphate synthase trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS MMS1_k127_420654_38 309801.trd_0104 5.463e-82 286.0 COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi,27XT8@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 MMS1_k127_420654_50 298653.Franean1_5198 7.817e-62 219.0 COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4EVCG@85013|Frankiales 201174|Actinobacteria S Bacterial transferase hexapeptide (six repeats) gca - - ko:K02617 - - - - ko00000 - - - Hexapep MMS1_k127_420654_18 1229780.BN381_40072 4.031e-150 487.0 COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,3UWEY@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03977 - - - - ko00000,ko03009 - - - Cytidylate_kin,KH_dom-like,MMR_HSR1 MMS1_k127_420654_21 1121877.JQKF01000026_gene2442 4.474e-137 449.0 COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CMW9@84992|Acidimicrobiia 84992|Acidimicrobiia C Protein of unknown function (DUF512) - - - - - - - - - - - - DUF512 MMS1_k127_420654_24 1313172.YM304_25520 8.809e-125 408.0 COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CMP7@84992|Acidimicrobiia 84992|Acidimicrobiia IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB MMS1_k127_420654_57 1050202.KB913024_gene1976 3.523e-55 207.0 COG1215@1|root,COG1215@2|Bacteria,2I3M7@201174|Actinobacteria,409K1@622450|Actinopolysporales 201174|Actinobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 MMS1_k127_420654_72 1229780.BN381_290068 3.708e-39 155.0 COG0204@1|root,COG0283@1|root,COG0204@2|Bacteria,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,3UWT7@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Cytidylate kinase cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Acyltransferase,Cytidylate_kin MMS1_k127_420654_66 1136417.AZWE01000047_gene2725 3.439e-45 173.0 COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4D918@85008|Micromonosporales 201174|Actinobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin MMS1_k127_420654_41 1123301.KB904188_gene1130 5.238e-79 283.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli 91061|Bacilli E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase MMS1_k127_420654_44 1313172.YM304_24990 1.932e-74 263.0 COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4CNBS@84992|Acidimicrobiia 84992|Acidimicrobiia E Prephenate dehydrogenase - - 1.3.1.12 ko:K00210,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH MMS1_k127_420654_43 1229780.BN381_290070 3.418e-77 269.0 COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,3UWKC@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J RNA pseudouridylate synthase rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 MMS1_k127_420654_74 1313172.YM304_24970 2.642e-38 150.0 COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4CN9J@84992|Acidimicrobiia 84992|Acidimicrobiia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB MMS1_k127_420654_59 1313172.YM304_24960 2.229e-52 198.0 COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria 201174|Actinobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA MMS1_k127_420654_28 1172181.KB911736_gene2437 4.385e-103 345.0 COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria 201174|Actinobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b MMS1_k127_420654_62 525909.Afer_1132 2.061e-50 188.0 COG1994@1|root,COG1994@2|Bacteria,2GM8E@201174|Actinobacteria 201174|Actinobacteria S Peptidase M50 rip2 - - - - - - - - - - - Peptidase_M50 MMS1_k127_420654_51 1122182.KB903838_gene3992 9.792e-62 223.0 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4DCDR@85008|Micromonosporales 201174|Actinobacteria L recombinase XerD xerD GO:0008150,GO:0040007 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase MMS1_k127_420654_86 1223543.GP2_042_00100 7.135e-24 108.0 COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4GAJA@85026|Gordoniaceae 201174|Actinobacteria L NUDIX domain nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX MMS1_k127_420654_5 1313172.YM304_24900 1.549e-234 738.0 COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4CMQD@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase MMS1_k127_420654_48 1385521.N803_09455 3.801e-62 236.0 COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4FEM6@85021|Intrasporangiaceae 201174|Actinobacteria L May be involved in recombinational repair of damaged DNA recN GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N MMS1_k127_420654_78 1111732.AZOD01000034_gene693 4.48e-36 147.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1X4HU@135614|Xanthomonadales 135614|Xanthomonadales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase MMS1_k127_420654_2 1380386.JIAW01000006_gene1226 1.367e-285 889.0 COG0365@1|root,COG0365@2|Bacteria,2GP7N@201174|Actinobacteria,23529@1762|Mycobacteriaceae 201174|Actinobacteria I PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C MMS1_k127_420654_20 1121877.JQKF01000037_gene1807 2.299e-146 497.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia 84992|Acidimicrobiia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS MMS1_k127_420654_36 485913.Krac_11733 3.553e-84 286.0 COG1024@1|root,COG1024@2|Bacteria,2G6BP@200795|Chloroflexi 200795|Chloroflexi I PFAM Enoyl-CoA hydratase isomerase - - - - - - - - - - - - ECH_1 MMS1_k127_420654_25 1172188.KB911820_gene2191 1.008e-117 396.0 COG4934@1|root,COG4934@2|Bacteria,2GMZ8@201174|Actinobacteria,4FIZM@85021|Intrasporangiaceae 201174|Actinobacteria O Peptidase S53 - - - ko:K08677 - - - - ko00000,ko01002 - - - Peptidase_S8 MMS1_k127_420654_31 101510.RHA1_ro00649 1.345e-95 323.0 COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria,4FY7G@85025|Nocardiaceae 201174|Actinobacteria P TrkA-N domain - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N MMS1_k127_420654_82 1089544.KB912942_gene1803 3.932e-31 126.0 COG0607@1|root,COG0607@2|Bacteria,2IQ2S@201174|Actinobacteria 201174|Actinobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese MMS1_k127_420654_69 743721.Psesu_2100 6.021e-41 158.0 COG5579@1|root,COG5579@2|Bacteria,1RGXV@1224|Proteobacteria,1S6K5@1236|Gammaproteobacteria,1X7GB@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1810) - - - - - - - - - - - - DUF1810 MMS1_k127_420654_9 66377.JOBH01000031_gene4502 1.572e-199 641.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria 201174|Actinobacteria C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 MMS1_k127_420654_70 298654.FraEuI1c_5570 6.802e-41 156.0 COG0454@1|root,COG0456@2|Bacteria,2IRBV@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_420654_34 246196.MSMEI_3201 3.213e-87 292.0 COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,23B1Y@1762|Mycobacteriaceae 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 MMS1_k127_420654_65 105425.BBPL01000074_gene3840 6.253e-48 178.0 COG2020@1|root,COG2020@2|Bacteria,2HUDA@201174|Actinobacteria,2NIQ9@228398|Streptacidiphilus 201174|Actinobacteria O Phospholipid methyltransferase - - - - - - - - - - - - PEMT MMS1_k127_420654_100 1030157.AFMP01000062_gene3609 2.496e-05 49.0 COG3210@1|root,COG3210@2|Bacteria,1NC4M@1224|Proteobacteria 1224|Proteobacteria U Protein of unknown function (DUF642) - - - - - - - - - - - - DUF642 MMS1_k127_420654_90 1030157.AFMP01000062_gene3609 4.48e-16 84.0 COG3210@1|root,COG3210@2|Bacteria,1NC4M@1224|Proteobacteria 1224|Proteobacteria U Protein of unknown function (DUF642) - - - - - - - - - - - - DUF642 MMS1_k127_420654_75 1283287.KB822575_gene513 7.327e-38 149.0 COG2945@1|root,COG2945@2|Bacteria,2I7T0@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_420654_63 1123320.KB889562_gene6755 8.602e-49 183.0 COG1409@1|root,COG1409@2|Bacteria,2HKQQ@201174|Actinobacteria 201174|Actinobacteria T Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos MMS1_k127_45462_5 1121877.JQKF01000007_gene967 5.944e-86 287.0 COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia 84992|Acidimicrobiia C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 MMS1_k127_45462_7 1123065.ATWL01000007_gene3162 4.729e-46 169.0 COG3576@1|root,COG3576@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Putative_PNPOx MMS1_k127_45462_11 710111.FraQA3DRAFT_6204 5.435e-30 124.0 COG1846@1|root,COG1846@2|Bacteria,2IIPH@201174|Actinobacteria 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 MMS1_k127_45462_1 326424.FRAAL5326 4.471e-240 754.0 COG0477@1|root,COG0477@2|Bacteria,2GJSC@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_45462_3 1120950.KB892752_gene6216 3.788e-165 532.0 COG0004@1|root,COG0004@2|Bacteria,2GKWU@201174|Actinobacteria 201174|Actinobacteria P Ammonium Transporter Family - - - - - - - - - - - - Ammonium_transp MMS1_k127_45462_8 452652.KSE_23320 9.485e-44 161.0 COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,2M3NY@2063|Kitasatospora 201174|Actinobacteria K Nitrogen regulatory protein P-II glnB GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II MMS1_k127_45462_12 1312954.KI914868_gene112 6.84e-05 53.0 2CNM1@1|root,32SHB@2|Bacteria,2GKWT@201174|Actinobacteria 201174|Actinobacteria S Nuclease-related domain - - - - - - - - - - - - NERD MMS1_k127_45462_6 351607.Acel_0075 5.381e-80 274.0 COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4ERI8@85013|Frankiales 201174|Actinobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 MMS1_k127_45462_0 1121877.JQKF01000006_gene910 4.28e-301 932.0 COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CMVI@84992|Acidimicrobiia 84992|Acidimicrobiia O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 MMS1_k127_45462_9 525909.Afer_1961 1.553e-36 145.0 COG0576@1|root,COG0576@2|Bacteria,2HGAI@201174|Actinobacteria,4CN9N@84992|Acidimicrobiia 84992|Acidimicrobiia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE MMS1_k127_45462_4 1146883.BLASA_4678 1.112e-97 330.0 COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4ERZT@85013|Frankiales 201174|Actinobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG MMS1_k127_45462_10 525909.Afer_1963 6.195e-32 132.0 COG0789@1|root,COG0789@2|Bacteria,2GR1T@201174|Actinobacteria,4CN4Z@84992|Acidimicrobiia 84992|Acidimicrobiia K helix_turn_helix, mercury resistance - - - ko:K13640 - - - - ko00000,ko03000 - - - MerR_1 MMS1_k127_45462_2 1121877.JQKF01000006_gene914 5.405e-170 546.0 COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CMTX@84992|Acidimicrobiia 84992|Acidimicrobiia O C-terminal, D2-small domain, of ClpB protein clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N MMS1_k127_485475_0 118173.KB235914_gene2725 7.976e-40 150.0 COG4679@1|root,COG4679@2|Bacteria,1G6N5@1117|Cyanobacteria,1HC3R@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 MMS1_k127_485475_2 1122194.AUHU01000003_gene2268 8.014e-27 113.0 COG1396@1|root,COG1396@2|Bacteria,1P0VP@1224|Proteobacteria,1SSAM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - - MMS1_k127_485475_1 103690.17134415 5.814e-27 118.0 COG4226@1|root,COG4226@2|Bacteria,1G90M@1117|Cyanobacteria,1HU6K@1161|Nostocales 1117|Cyanobacteria S HicB family hicB - - - - - - - - - - - HicB MMS1_k127_485475_4 472759.Nhal_3031 1.155e-15 79.0 2CT64@1|root,32SSN@2|Bacteria,1N7H4@1224|Proteobacteria,1SEH7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HicA toxin of bacterial toxin-antitoxin, - - - - - - - - - - - - HicA_toxin MMS1_k127_485475_3 237368.SCABRO_03655 1.901e-19 91.0 COG3668@1|root,COG3668@2|Bacteria,2J4NM@203682|Planctomycetes 203682|Planctomycetes S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin MMS1_k127_485475_5 1379270.AUXF01000005_gene317 4.28e-11 75.0 COG5492@1|root,COG5492@2|Bacteria,1ZUA8@142182|Gemmatimonadetes 142182|Gemmatimonadetes N Bacterial Ig-like domain 2 - - - - - - - - - - - - Big_2 MMS1_k127_502513_0 290397.Adeh_1021 4.839e-62 229.0 COG3239@1|root,COG3239@2|Bacteria,1PP7Y@1224|Proteobacteria,43525@68525|delta/epsilon subdivisions,2X94I@28221|Deltaproteobacteria,2Z1VN@29|Myxococcales 28221|Deltaproteobacteria I fatty acid desaturase - - 1.14.19.3 ko:K00508 ko00591,ko01100,map00591,map01100 - R07063 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase MMS1_k127_502513_1 1313172.YM304_34610 5.52e-23 104.0 COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria 201174|Actinobacteria K Cold shock protein - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD MMS1_k127_564083_34 298653.Franean1_5677 2.403e-17 82.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4EVHQ@85013|Frankiales 201174|Actinobacteria L Transposase, IS605 OrfB family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon MMS1_k127_564083_10 196162.Noca_3275 1.429e-76 270.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4DV63@85009|Propionibacteriales 201174|Actinobacteria L Helix-turn-helix domain - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon MMS1_k127_564083_32 926550.CLDAP_13020 1.096e-18 92.0 COG0169@1|root,COG0454@1|root,COG0169@2|Bacteria,COG0456@2|Bacteria,2G6FG@200795|Chloroflexi 200795|Chloroflexi E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_dh_N MMS1_k127_564083_30 670292.JH26_09595 1.618e-36 149.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,1JTPR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF4096 MMS1_k127_564083_24 1111479.AXAR01000010_gene2593 1.725e-46 177.0 COG1999@1|root,COG1999@2|Bacteria,1W0ZX@1239|Firmicutes 1239|Firmicutes S SCO1/SenC - - - - - - - - - - - - SCO1-SenC MMS1_k127_564083_28 1123258.AQXZ01000010_gene3650 8.42e-40 156.0 COG0671@1|root,COG0671@2|Bacteria,2GNBT@201174|Actinobacteria 201174|Actinobacteria I Membrane-associated phospholipid phosphatase - - 3.6.1.27 ko:K06153,ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 MMS1_k127_564083_16 1283299.AUKG01000001_gene2313 6.924e-64 233.0 COG1055@1|root,COG1055@2|Bacteria 2|Bacteria P arsenite transmembrane transporter activity arsB - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - ArsB MMS1_k127_564083_27 58123.JOFJ01000028_gene2818 2.246e-40 155.0 2A18G@1|root,30PEU@2|Bacteria,2IGED@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_564083_29 926567.TheveDRAFT_1573 8.729e-37 154.0 COG0106@1|root,COG0106@2|Bacteria,3TAX8@508458|Synergistetes 508458|Synergistetes E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth MMS1_k127_564083_33 1378168.N510_01457 2.124e-17 85.0 COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes 1239|Firmicutes S protein, YerC YecD - - - - - - - - - - - - Trp_repressor MMS1_k127_564083_20 1442599.JAAN01000024_gene1926 1.384e-50 190.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1X4SF@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C MMS1_k127_564083_12 1433126.BN938_1490 3.065e-74 262.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,2FMY9@200643|Bacteroidia,22UPS@171550|Rikenellaceae 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh MMS1_k127_564083_26 1380347.JNII01000008_gene4174 3.522e-41 172.0 COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4ESDH@85013|Frankiales 201174|Actinobacteria E Imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD MMS1_k127_564083_31 1120985.AUMI01000017_gene2665 1.09e-35 147.0 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,4H3NT@909932|Negativicutes 909932|Negativicutes E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase MMS1_k127_564083_11 1307436.PBF_08593 1.691e-76 266.0 COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,4HAAM@91061|Bacilli,1ZAUX@1386|Bacillus 91061|Bacilli E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS14115 His_biosynth MMS1_k127_564083_22 1123267.JONN01000001_gene1187 6.132e-48 177.0 COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria,2K56R@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH MMS1_k127_564083_9 1449353.JQMQ01000005_gene1720 2.619e-95 325.0 COG1840@1|root,COG1840@2|Bacteria,2HN57@201174|Actinobacteria,2NHAS@228398|Streptacidiphilus 201174|Actinobacteria P Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_6 MMS1_k127_564083_6 1121877.JQKF01000018_gene2549 2.126e-125 422.0 COG1178@1|root,COG1178@2|Bacteria,2HFVM@201174|Actinobacteria,4CP3M@84992|Acidimicrobiia 84992|Acidimicrobiia U Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 MMS1_k127_564083_13 1128421.JAGA01000002_gene423 8.172e-70 254.0 COG3842@1|root,COG3842@2|Bacteria,2NPAF@2323|unclassified Bacteria 2|Bacteria E ATPases associated with a variety of cellular activities potA - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 MMS1_k127_564083_14 1449355.JQNR01000004_gene1668 9.922e-67 236.0 COG4280@1|root,COG4280@2|Bacteria,2GN58@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - UPF0016 MMS1_k127_564083_8 935863.AWZR01000004_gene697 1.607e-111 365.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X5FC@135614|Xanthomonadales 135614|Xanthomonadales S Extradiol ring-cleavage dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB MMS1_k127_564083_7 1382306.JNIM01000001_gene1328 2.202e-122 405.0 COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi 200795|Chloroflexi C Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N MMS1_k127_564083_3 1237500.ANBA01000015_gene2234 2.519e-151 488.0 COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4EGFJ@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase MMS1_k127_564083_1 345341.KUTG_08193 6.153e-215 695.0 COG2274@1|root,COG2274@2|Bacteria,2I2QC@201174|Actinobacteria,4EE39@85010|Pseudonocardiales 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 MMS1_k127_564083_0 1449976.KALB_3115 5.469e-218 692.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DXBD@85010|Pseudonocardiales 201174|Actinobacteria V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran MMS1_k127_564083_23 1525715.IX54_13325 3.364e-47 177.0 COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,2TRS7@28211|Alphaproteobacteria,2PVWX@265|Paracoccus 28211|Alphaproteobacteria F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase MMS1_k127_564083_15 679197.HMPREF9336_03315 1.103e-66 230.0 COG0590@1|root,COG0590@2|Bacteria,2IFH2@201174|Actinobacteria 201174|Actinobacteria FJ deaminase codA - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 MMS1_k127_564083_17 298654.FraEuI1c_3779 7.082e-61 217.0 COG0503@1|root,COG0503@2|Bacteria,2H50R@201174|Actinobacteria 201174|Actinobacteria F Phosphoribosyl transferase domain - - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran MMS1_k127_564083_5 1121877.JQKF01000011_gene366 2.722e-128 428.0 COG1457@1|root,COG1457@2|Bacteria,2GJ6B@201174|Actinobacteria,4CNGD@84992|Acidimicrobiia 84992|Acidimicrobiia U Permease for cytosine/purines, uracil, thiamine, allantoin - - - - - - - - - - - - Transp_cyt_pur MMS1_k127_564083_25 1120936.KB907209_gene1795 1.137e-45 188.0 COG0747@1|root,COG0747@2|Bacteria,2GJ4B@201174|Actinobacteria,4EMZ3@85012|Streptosporangiales 201174|Actinobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS1_k127_564083_21 222534.KB893671_gene3118 1.854e-50 194.0 COG0477@1|root,COG0477@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_564083_35 756067.MicvaDRAFT_4327 6.92e-10 67.0 COG4300@1|root,COG4300@2|Bacteria,1G4E3@1117|Cyanobacteria,1HAVV@1150|Oscillatoriales 1117|Cyanobacteria P PFAM Cadmium resistance transporter - - - - - - - - - - - - Cad MMS1_k127_564083_18 324602.Caur_1249 1.018e-53 202.0 COG1171@1|root,COG1171@2|Bacteria,2G6ME@200795|Chloroflexi,3776A@32061|Chloroflexia 32061|Chloroflexia E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS1_k127_564083_4 33876.JNXY01000006_gene1147 1.447e-135 447.0 COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4DCEF@85008|Micromonosporales 201174|Actinobacteria E Glycine D-amino acid oxidases (deaminating) - - - - - - - - - - - - DAO MMS1_k127_564083_2 351607.Acel_1287 1.038e-196 625.0 COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4ERWH@85013|Frankiales 201174|Actinobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family tpa - - - - - - - - - - - Aminotran_3 MMS1_k127_564083_19 1122247.C731_1260 7.624e-51 188.0 COG1522@1|root,COG1522@2|Bacteria,2GP1P@201174|Actinobacteria,234U6@1762|Mycobacteriaceae 201174|Actinobacteria K AsnC family asnC - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type MMS1_k127_564083_36 1394178.AWOO02000087_gene933 8.969e-07 51.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4EFMP@85012|Streptosporangiales 201174|Actinobacteria C Aldehyde dehydrogenase family - - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_589874_30 1313172.YM304_09890 1.043e-12 74.0 COG0584@1|root,COG0584@2|Bacteria 2|Bacteria C glycerophosphodiester phosphodiesterase activity - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD MMS1_k127_589874_13 1313172.YM304_09910 1.785e-91 307.0 COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4CMXI@84992|Acidimicrobiia 84992|Acidimicrobiia C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF MMS1_k127_589874_11 1313172.YM304_09920 4.791e-98 330.0 COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4CMXZ@84992|Acidimicrobiia 84992|Acidimicrobiia C Electron transfer flavoprotein domain etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha MMS1_k127_589874_8 479433.Caci_7839 3.335e-118 396.0 COG0477@1|root,COG0477@2|Bacteria,2IBIG@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS1_k127_589874_22 396014.BF93_11205 2.898e-53 195.0 COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4FD4E@85020|Dermabacteraceae 201174|Actinobacteria BDLTU Phosphatidylinositol - - - - - - - - - - - - - MMS1_k127_589874_26 1121877.JQKF01000069_gene1260 3.531e-31 131.0 298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4CN9I@84992|Acidimicrobiia 84992|Acidimicrobiia S Protein of unknown function (DUF3090) - - - - - - - - - - - - DUF3090 MMS1_k127_589874_19 1313172.YM304_10000 1.321e-65 230.0 COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4CNCR@84992|Acidimicrobiia 84992|Acidimicrobiia G Histidine phosphatase superfamily (branch 1) - - - - - - - - - - - - His_Phos_1 MMS1_k127_589874_6 1229780.BN381_310078 3.032e-146 471.0 COG1035@1|root,COG1146@1|root,COG1035@2|Bacteria,COG1146@2|Bacteria,2GRHK@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term - - 1.12.98.1 ko:K00441 ko00680,ko01100,ko01120,map00680,map01100,map01120 - R03025 RC02628 ko00000,ko00001,ko01000 - - - Fer4_9,FrhB_FdhB_C,FrhB_FdhB_N MMS1_k127_589874_21 1229780.BN381_80351 1.272e-53 199.0 COG0266@1|root,COG0266@2|Bacteria,2H39J@201174|Actinobacteria 201174|Actinobacteria L formamidopyrimidine-DNA glycosylase - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS MMS1_k127_589874_24 1121877.JQKF01000001_gene1375 3.562e-42 162.0 COG0586@1|root,COG0586@2|Bacteria,2GN43@201174|Actinobacteria,4CNM9@84992|Acidimicrobiia 84992|Acidimicrobiia S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc MMS1_k127_589874_23 656024.FsymDg_1291 6.138e-49 179.0 COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4ESII@85013|Frankiales 201174|Actinobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcp GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA MMS1_k127_589874_10 543632.JOJL01000041_gene1968 1.752e-107 361.0 COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4D8GJ@85008|Micromonosporales 201174|Actinobacteria L DEAD DEAH box helicase - - - - - - - - - - - - DEAD,Helicase_C MMS1_k127_589874_18 1246448.ANAZ01000040_gene483 1.882e-67 248.0 COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4EGBS@85012|Streptosporangiales 201174|Actinobacteria S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L MMS1_k127_589874_12 298654.FraEuI1c_4031 1.384e-93 333.0 COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4ERV6@85013|Frankiales 201174|Actinobacteria P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp MMS1_k127_589874_0 103733.JNYO01000021_gene6765 0.0 1099.0 COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DY9U@85010|Pseudonocardiales 201174|Actinobacteria C aconitate hydratase acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C MMS1_k127_589874_3 1229780.BN381_680005 1.615e-204 651.0 COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,3UW91@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d MMS1_k127_589874_9 1394178.AWOO02000017_gene6792 1.704e-110 372.0 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4EN8T@85012|Streptosporangiales 201174|Actinobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS1_k127_589874_15 471852.Tcur_2359 6.541e-79 281.0 COG1216@1|root,COG1216@2|Bacteria,2I176@201174|Actinobacteria,4EM9E@85012|Streptosporangiales 201174|Actinobacteria S Glycosyl transferase family 21 - - - - - - - - - - - - Glycos_transf_2 MMS1_k127_589874_28 222534.KB893716_gene1804 3.443e-15 79.0 COG0535@1|root,COG0535@2|Bacteria,2GQQT@201174|Actinobacteria,4ETI8@85013|Frankiales 201174|Actinobacteria S Mycofactocin system - - - - - - - - - - - - - MMS1_k127_589874_5 1229780.BN381_250081 8.458e-163 522.0 COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria 201174|Actinobacteria C Radical SAM pqqE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_12,Radical_SAM,SPASM MMS1_k127_589874_4 1380347.JNII01000007_gene88 1.96e-170 551.0 COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4ES98@85013|Frankiales 201174|Actinobacteria C Conserved region in glutamate synthase - - 1.1.2.3,1.1.3.15 ko:K00101,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00196,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FMN_dh MMS1_k127_589874_16 994479.GL877879_gene5203 5.102e-70 246.0 COG1028@1|root,COG1028@2|Bacteria,2ICJK@201174|Actinobacteria,4E3I3@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 MMS1_k127_589874_1 525368.HMPREF0591_5352 8.933e-220 691.0 COG0446@1|root,COG0446@2|Bacteria,2IB5R@201174|Actinobacteria,23756@1762|Mycobacteriaceae 201174|Actinobacteria S but shows high identity with sulfide-quinone reductase from chlorobium tepidum - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS1_k127_589874_27 446466.Cfla_0362 9.599e-22 100.0 COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,4F1HU@85016|Cellulomonadaceae 201174|Actinobacteria S Metal-sensitive transcriptional repressor csoR - - - - - - - - - - - Trns_repr_metal MMS1_k127_589874_2 1906.SFRA_07800 3.02e-210 671.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,2H7WY@201174|Actinobacteria 201174|Actinobacteria P oxidoreductase cdr - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,Rhodanese MMS1_k127_589874_20 1313172.YM304_36240 1.456e-59 214.0 COG2227@1|root,COG2227@2|Bacteria,2I6J5@201174|Actinobacteria 201174|Actinobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 MMS1_k127_589874_17 543632.JOJL01000061_gene2315 1.329e-67 251.0 COG4987@1|root,COG4987@2|Bacteria,2H79B@201174|Actinobacteria,4DAZ1@85008|Micromonosporales 201174|Actinobacteria CO ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC cydC - - ko:K16012 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran MMS1_k127_589874_14 591159.ACEZ01000134_gene2353 7.958e-82 291.0 COG4987@1|root,COG4988@1|root,COG4987@2|Bacteria,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria 201174|Actinobacteria V ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD cydD - - ko:K16013,ko:K16014 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran MMS1_k127_589874_7 525909.Afer_0524 7.204e-126 412.0 COG1294@1|root,COG1294@2|Bacteria,2GMFV@201174|Actinobacteria 201174|Actinobacteria C cytochrome D ubiquinol oxidase subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II MMS1_k127_589874_25 525909.Afer_0525 7.945e-41 155.0 COG1271@1|root,COG1271@2|Bacteria,2GJE4@201174|Actinobacteria,4CNUJ@84992|Acidimicrobiia 84992|Acidimicrobiia C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I MMS1_k127_606812_20 1382306.JNIM01000001_gene3011 1.21e-21 98.0 COG1042@1|root,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi 200795|Chloroflexi C PFAM CoA-binding domain protein - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig MMS1_k127_606812_18 469371.Tbis_1272 1.079e-23 107.0 COG1725@1|root,COG1725@2|Bacteria,2IHTD@201174|Actinobacteria,4E5RN@85010|Pseudonocardiales 201174|Actinobacteria K Transcriptional regulator - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR MMS1_k127_606812_17 1348338.ADILRU_0895 4.4e-24 106.0 COG1813@1|root,COG1813@2|Bacteria 2|Bacteria K peptidyl-tyrosine sulfation - - - - - - - - - - - - HTH_3,HTH_31 MMS1_k127_606812_3 1134912.AJTV01000011_gene2501 4.078e-137 447.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,2TVQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM HipA domain protein - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C MMS1_k127_606812_24 1191299.AJYX01000024_gene2778 2.666e-08 55.0 2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS1_k127_606812_11 1463895.JODA01000003_gene901 2.643e-38 166.0 COG3391@1|root,COG3767@1|root,COG5492@1|root,COG3391@2|Bacteria,COG3767@2|Bacteria,COG5492@2|Bacteria,2GK45@201174|Actinobacteria 201174|Actinobacteria M 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Big_3_5,Cytochrom_D1,Lactonase MMS1_k127_606812_26 1121373.KB903631_gene616 0.0001419 54.0 COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40 MMS1_k127_606812_0 525909.Afer_1871 2.213e-216 705.0 COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4CMW1@84992|Acidimicrobiia 84992|Acidimicrobiia S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 MMS1_k127_606812_25 525909.Afer_1872 1.181e-05 58.0 COG2268@1|root,COG2268@2|Bacteria,2I6VU@201174|Actinobacteria,4CN97@84992|Acidimicrobiia 84992|Acidimicrobiia S Band 7 protein - - - - - - - - - - - - - MMS1_k127_606812_12 1112204.GPOL_c33450 9.808e-36 150.0 COG3480@1|root,COG3480@2|Bacteria,2GJDD@201174|Actinobacteria,4GBJW@85026|Gordoniaceae 201174|Actinobacteria T Domain present in PSD-95, Dlg, and ZO-1/2. lon - - ko:K07177 ko02024,map02024 - - - ko00000,ko00001,ko01002 - - - Lon_C,PDZ_2 MMS1_k127_606812_19 525909.Afer_1896 1.202e-21 107.0 COG1413@1|root,COG1413@2|Bacteria,2HA0J@201174|Actinobacteria,4CNCY@84992|Acidimicrobiia 84992|Acidimicrobiia C PBS lyase HEAT-like repeat - - - - - - - - - - - - HEAT_2 MMS1_k127_606812_6 1313172.YM304_09040 7.388e-68 243.0 COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CMUQ@84992|Acidimicrobiia 201174|Actinobacteria D Cell division protein FtsA mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl MMS1_k127_606812_23 1306174.JODP01000006_gene3413 2.201e-08 66.0 COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria 201174|Actinobacteria S protein, coenzyme F420 biosynthesis associated - - - - - - - - - - - - Zincin_2 MMS1_k127_606812_22 485913.Krac_0016 1.796e-08 60.0 COG3293@1|root,COG3293@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 MMS1_k127_606812_13 196162.Noca_3275 4.846e-31 128.0 COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4DV63@85009|Propionibacteriales 201174|Actinobacteria L Helix-turn-helix domain - - - ko:K07496 - - - - ko00000 - - - HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon MMS1_k127_606812_15 1449355.JQNR01000004_gene1881 1.709e-27 117.0 COG3370@1|root,COG3370@2|Bacteria,2GS08@201174|Actinobacteria 201174|Actinobacteria O peroxiredoxin activity - - - - - - - - - - - - DrsE MMS1_k127_606812_8 1280944.HY17_11540 9.583e-59 210.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,43WEP@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysC - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,DUF2061,GTP_EFTU,GTP_EFTU_D2 MMS1_k127_606812_14 1121448.DGI_4038 5.622e-28 125.0 COG3551@1|root,COG3551@2|Bacteria,1RB2G@1224|Proteobacteria,42UMV@68525|delta/epsilon subdivisions,2WR43@28221|Deltaproteobacteria,2MDHR@213115|Desulfovibrionales 28221|Deltaproteobacteria J Sulfotransferase family - - - - - - - - - - - - - MMS1_k127_606812_5 931627.MycrhDRAFT_4679 1.79e-93 322.0 COG3174@1|root,COG3174@2|Bacteria,2I9JX@201174|Actinobacteria,236IQ@1762|Mycobacteriaceae 201174|Actinobacteria S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC MMS1_k127_606812_21 298655.KI912266_gene6084 9.01e-11 71.0 COG5401@1|root,COG5401@2|Bacteria,2H4HT@201174|Actinobacteria 201174|Actinobacteria S Immunoglobulin-like domain of bacterial spore germination - - - - - - - - - - - - Germane,Gmad2 MMS1_k127_606812_10 1906.SFRA_26615 3.14e-44 164.0 COG1553@1|root,COG1553@2|Bacteria,2IRB2@201174|Actinobacteria 201174|Actinobacteria P DsrE/DsrF-like family - - - ko:K06039 - - - - ko00000 - - - DrsE MMS1_k127_606812_1 1449069.JMLO01000035_gene2669 3.051e-194 627.0 COG0038@1|root,COG0038@2|Bacteria,2GPPN@201174|Actinobacteria,4FZU3@85025|Nocardiaceae 201174|Actinobacteria P Voltage gated chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC MMS1_k127_606812_7 204773.HEAR1081 2.914e-59 213.0 COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria,474I0@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 MMS1_k127_606812_16 390989.JOEG01000013_gene2527 1.562e-24 111.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity gstF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - AHSA1,GST_C,GST_N_3 MMS1_k127_606812_4 1306174.JODP01000022_gene19 4.82e-101 344.0 COG4934@1|root,COG4934@2|Bacteria,2IB5Q@201174|Actinobacteria 201174|Actinobacteria O collagen metabolic process - - - - - - - - - - - - - MMS1_k127_606812_9 1048339.KB913029_gene1680 3.749e-57 202.0 COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,4ET2T@85013|Frankiales 201174|Actinobacteria T low molecular weight arsC - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - HTH_5,LMWPc MMS1_k127_606812_2 1146883.BLASA_3638 3.547e-165 526.0 COG0798@1|root,COG0798@2|Bacteria,2GJ4H@201174|Actinobacteria 201174|Actinobacteria P arsenical-resistance protein arsB - 1.20.4.1 ko:K03325,ko:K03741 - - - - ko00000,ko01000,ko02000 2.A.59 - - SBF MMS1_k127_609347_14 649638.Trad_2669 8.165e-36 140.0 COG0641@1|root,COG3012@1|root,COG0641@2|Bacteria,COG3012@2|Bacteria 2|Bacteria C radical SAM aslB GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:1901564 - ko:K06871,ko:K09858 - - - - ko00000 - - - Fer4_12,PRiA4_ORF3,Radical_SAM,SEC-C,SPASM MMS1_k127_609347_5 1121372.AULK01000016_gene480 9.331e-134 435.0 COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4FKQE@85023|Microbacteriaceae 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS1_k127_609347_2 105422.BBPM01000001_gene4705 8.552e-157 503.0 COG0673@1|root,COG0673@2|Bacteria,2GK0F@201174|Actinobacteria,2NEU0@228398|Streptacidiphilus 201174|Actinobacteria E Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS1_k127_609347_11 1246995.AFR_20730 2.537e-94 321.0 COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4DBT5@85008|Micromonosporales 201174|Actinobacteria S Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) iolG - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS1_k127_609347_13 1449353.JQMQ01000005_gene4947 1.757e-63 226.0 COG2188@1|root,COG2188@2|Bacteria,2GJZ1@201174|Actinobacteria,2NMEB@228398|Streptacidiphilus 201174|Actinobacteria K UTRA - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA MMS1_k127_609347_6 543632.JOJL01000004_gene4034 2.409e-128 419.0 COG1082@1|root,COG1082@2|Bacteria,2GK1S@201174|Actinobacteria 201174|Actinobacteria G Xylose isomerase domain protein TIM barrel - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N MMS1_k127_609347_12 529884.Rhola_00013320 9.769e-69 247.0 COG1879@1|root,COG1879@2|Bacteria,2GKIJ@201174|Actinobacteria,4FNHH@85023|Microbacteriaceae 201174|Actinobacteria G Periplasmic binding protein domain - - - ko:K02058 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 MMS1_k127_609347_10 749414.SBI_09523 2.942e-95 323.0 COG1172@1|root,COG1172@2|Bacteria,2GM9E@201174|Actinobacteria 201174|Actinobacteria G Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 MMS1_k127_609347_8 67356.KL575651_gene5489 1.805e-103 344.0 COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria 201174|Actinobacteria G ABC transporter - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran MMS1_k127_609347_4 1121924.ATWH01000016_gene3005 1.316e-138 447.0 COG0524@1|root,COG0524@2|Bacteria,2GM3N@201174|Actinobacteria,4FM32@85023|Microbacteriaceae 201174|Actinobacteria G pfkB family carbohydrate kinase iolC - 2.7.1.92 ko:K03338 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB MMS1_k127_609347_7 33876.JNXY01000016_gene6913 4.936e-110 363.0 COG1830@1|root,COG1830@2|Bacteria,2GKTN@201174|Actinobacteria,4DBMP@85008|Micromonosporales 201174|Actinobacteria G deoxyribose-phosphate aldolase - - - - - - - - - - - - - MMS1_k127_609347_9 1246995.AFR_20695 1.834e-103 345.0 COG3718@1|root,COG3718@2|Bacteria,2GM8S@201174|Actinobacteria,4DC1Q@85008|Micromonosporales 201174|Actinobacteria G KduI/IolB family iolB - 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08503 RC00541 ko00000,ko00001,ko01000 - - - KduI MMS1_k127_609347_0 33876.JNXY01000016_gene6911 2.857e-276 865.0 COG3962@1|root,COG3962@2|Bacteria,2GMCJ@201174|Actinobacteria,4D98S@85008|Micromonosporales 201174|Actinobacteria E Belongs to the TPP enzyme family iolD - 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08603 RC02331 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N MMS1_k127_609347_1 543632.JOJL01000039_gene1647 6.142e-238 747.0 COG1012@1|root,COG1012@2|Bacteria,2GJI2@201174|Actinobacteria,4D8Q2@85008|Micromonosporales 201174|Actinobacteria C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_609347_3 351607.Acel_1810 6.872e-147 469.0 COG1082@1|root,COG1082@2|Bacteria,2GMU1@201174|Actinobacteria,4EUHF@85013|Frankiales 201174|Actinobacteria G PFAM Xylose isomerase domain protein TIM barrel iolH - - ko:K06605 - - - - ko00000 - - - AP_endonuc_2 MMS1_k127_609347_15 105425.BBPL01000001_gene6150 9.591e-29 118.0 COG0477@1|root,COG0477@2|Bacteria,2I2QX@201174|Actinobacteria,2NKFT@228398|Streptacidiphilus 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,TRI12 MMS1_k127_683476_0 1245475.ANAE01000203_gene2207 7.223e-58 227.0 COG1372@1|root,COG1372@2|Bacteria,2I1EI@201174|Actinobacteria,4EN37@85012|Streptosporangiales 201174|Actinobacteria L N-acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - Amidase_2 MMS1_k127_683476_2 1206720.BAFQ01000164_gene4290 2.019e-07 62.0 COG1216@1|root,COG1216@2|Bacteria,2HHDG@201174|Actinobacteria,4FXTX@85025|Nocardiaceae 201174|Actinobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - - MMS1_k127_683476_1 1268072.PSAB_20490 1.684e-31 137.0 2AUEM@1|root,31K2N@2|Bacteria,1UPSN@1239|Firmicutes,4IVA4@91061|Bacilli,26WJ8@186822|Paenibacillaceae 91061|Bacilli S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 MMS1_k127_70565_4 1122609.AUGT01000001_gene2841 1.55e-118 391.0 COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria 201174|Actinobacteria NU twitching motility protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE MMS1_k127_70565_23 991905.SL003B_0334 3.42e-14 82.0 COG4923@1|root,COG4923@2|Bacteria,1MY1R@1224|Proteobacteria,2U4CU@28211|Alphaproteobacteria,4BSE3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF429) - - - - - - - - - - - - DUF429 MMS1_k127_70565_14 1157638.KB892165_gene3607 3.4e-64 228.0 COG1989@1|root,COG1989@2|Bacteria,2IDFY@201174|Actinobacteria 201174|Actinobacteria NOU Bacterial Peptidase A24 N-terminal domain - - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 MMS1_k127_70565_22 479431.Namu_0205 1.574e-19 105.0 2C4J7@1|root,33WAI@2|Bacteria,2HB21@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_70565_0 350058.Mvan_1968 1.273e-197 650.0 COG0476@1|root,COG0476@2|Bacteria,2HQ2F@201174|Actinobacteria,234X5@1762|Mycobacteriaceae 201174|Actinobacteria H involved in biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD) moeY GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0061503,GO:0061504,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - - - - - - - - - - Nitroreductase,ThiF MMS1_k127_70565_3 1150599.MPHLEI_09569 2.415e-150 503.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,233TE@1762|Mycobacteriaceae 201174|Actinobacteria T GGDEF domain - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009165,GO:0009166,GO:0009187,GO:0009190,GO:0009214,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0052621,GO:0055086,GO:0071111,GO:0071704,GO:0071944,GO:0090407,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 - - - - - - - - - - EAL,GAF,GAF_2,GGDEF MMS1_k127_70565_21 292459.STH1699 1.091e-26 120.0 COG2202@1|root,COG5001@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9 MMS1_k127_70565_10 1279019.ARQK01000042_gene2036 6.808e-78 280.0 COG0642@1|root,COG2206@1|root,COG2205@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T domain protein - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_4,PAS_9 MMS1_k127_70565_2 1121877.JQKF01000037_gene1807 2.878e-158 524.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4CNHH@84992|Acidimicrobiia 84992|Acidimicrobiia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS MMS1_k127_70565_6 631362.Thi970DRAFT_01365 4.954e-108 371.0 COG0426@1|root,COG2199@1|root,COG0426@2|Bacteria,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1WXES@135613|Chromatiales 135613|Chromatiales CT Diguanylate cyclase - - - - - - - - - - - - GGDEF MMS1_k127_70565_1 1121877.JQKF01000004_gene1141 5.282e-185 589.0 COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CNNJ@84992|Acidimicrobiia 84992|Acidimicrobiia C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic MMS1_k127_70565_13 1038858.AXBA01000013_gene2426 1.657e-64 231.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,3EY51@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Carbon-nitrogen hydrolase MA20_39720 - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase MMS1_k127_70565_16 1120948.KB903224_gene363 1.156e-55 203.0 COG2267@1|root,COG2267@2|Bacteria,2IKTK@201174|Actinobacteria,4EF24@85010|Pseudonocardiales 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6 MMS1_k127_70565_17 452652.KSE_24610 6.187e-42 173.0 COG0457@1|root,COG0457@2|Bacteria,2I6ET@201174|Actinobacteria 201174|Actinobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - MMS1_k127_70565_8 1444712.BN1013_00667 4.387e-89 315.0 COG1960@1|root,COG1960@2|Bacteria 2|Bacteria I acyl-CoA dehydrogenase activity aidB - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M MMS1_k127_70565_15 477641.MODMU_1884 1.16e-59 221.0 COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4ET2I@85013|Frankiales 201174|Actinobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport MMS1_k127_70565_25 1229780.BN381_10298 2.443e-07 58.0 COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,3UXQ8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp MMS1_k127_70565_7 1313172.YM304_28170 4.352e-90 308.0 COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4CMXH@84992|Acidimicrobiia 84992|Acidimicrobiia BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl MMS1_k127_70565_20 1449976.KALB_6902 1.102e-34 146.0 COG0454@1|root,COG1042@1|root,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DYY0@85010|Pseudonocardiales 201174|Actinobacteria CK Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig MMS1_k127_70565_19 1463934.JOCF01000074_gene5956 1.058e-37 153.0 COG3393@1|root,COG3393@2|Bacteria,2GN6B@201174|Actinobacteria 201174|Actinobacteria O PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,FR47 MMS1_k127_70565_5 13689.BV96_02312 6.027e-116 404.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh MMS1_k127_70565_11 397278.JOJN01000002_gene611 2.508e-72 254.0 COG0715@1|root,COG0715@2|Bacteria,2IJ9K@201174|Actinobacteria,4DTZU@85009|Propionibacteriales 201174|Actinobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - - - - - - - - - - NMT1,NMT1_2 MMS1_k127_70565_9 266117.Rxyl_2741 9.058e-82 283.0 COG0252@1|root,COG0252@2|Bacteria,2HUB2@201174|Actinobacteria,4CQAH@84995|Rubrobacteria 84995|Rubrobacteria EJ Asparaginase glutaminase - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase MMS1_k127_70565_12 1288298.rosmuc_04249 6.802e-67 241.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,46P7P@74030|Roseovarius 28211|Alphaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - - - - - - - - - - DUF2437,FAA_hydrolase MMS1_k127_70565_18 219305.MCAG_04530 6.124e-41 157.0 COG4974@1|root,COG4974@2|Bacteria,2I9XB@201174|Actinobacteria,4DD29@85008|Micromonosporales 201174|Actinobacteria L PFAM plasmid pRiA4b ORF-3 family protein - - - - - - - - - - - - PRiA4_ORF3 MMS1_k127_786468_37 58123.JOFJ01000034_gene44 9.032e-40 159.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_8 MMS1_k127_786468_28 1254432.SCE1572_23645 4.329e-65 246.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2YUC3@29|Myxococcales 28221|Deltaproteobacteria T signal transduction histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4,PAS_8,Response_reg MMS1_k127_786468_27 1313172.YM304_38610 5.403e-66 232.0 COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4CNQN@84992|Acidimicrobiia 84992|Acidimicrobiia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C MMS1_k127_786468_38 1121877.JQKF01000015_gene79 1.033e-39 161.0 COG1959@1|root,COG1959@2|Bacteria,2GS0E@201174|Actinobacteria,4CNRF@84992|Acidimicrobiia 84992|Acidimicrobiia K Transcriptional regulator - - - - - - - - - - - - Rrf2 MMS1_k127_786468_7 525909.Afer_1450 1.021e-147 494.0 COG0493@1|root,COG0716@1|root,COG1146@1|root,COG0493@2|Bacteria,COG0716@2|Bacteria,COG1146@2|Bacteria,2GJ0A@201174|Actinobacteria,4CNNR@84992|Acidimicrobiia 84992|Acidimicrobiia C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Pyr_redox_2 MMS1_k127_786468_4 1121877.JQKF01000015_gene80 4.005e-182 584.0 COG0348@1|root,COG0348@2|Bacteria,2HGM0@201174|Actinobacteria,4CNIT@84992|Acidimicrobiia 84992|Acidimicrobiia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 MMS1_k127_786468_35 1382306.JNIM01000001_gene1112 9.779e-48 181.0 COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi 200795|Chloroflexi K Two component transcriptional regulator, LuxR family - - - - - - - - - - - - GerE,Response_reg MMS1_k127_786468_25 196162.Noca_2942 4.606e-73 264.0 COG4585@1|root,COG4585@2|Bacteria,2HESU@201174|Actinobacteria,4DVT5@85009|Propionibacteriales 201174|Actinobacteria T PAS domain - - - - - - - - - - - - HATPase_c,HisKA_3 MMS1_k127_786468_30 644966.Tmar_1356 3.507e-60 216.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,3WDS9@538999|Clostridiales incertae sedis 186801|Clostridia K COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07668,ko:K07775 ko02020,map02020 M00458,M00459 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C MMS1_k127_786468_31 326424.FRAAL4442 3.103e-55 197.0 COG1225@1|root,COG1225@2|Bacteria,2IFB1@201174|Actinobacteria 201174|Actinobacteria O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcpB - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA MMS1_k127_786468_15 1120917.AQXM01000063_gene2031 2.691e-106 367.0 COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,1W7MS@1268|Micrococcaceae 201174|Actinobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS1_k127_786468_9 477641.MODMU_5239 3.442e-137 448.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4ES0E@85013|Frankiales 201174|Actinobacteria C PFAM Transketolase central region pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C MMS1_k127_786468_8 479432.Sros_8974 2.446e-137 446.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4EG6N@85012|Streptosporangiales 201174|Actinobacteria C Dehydrogenase E1 component pdhA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K00166 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh MMS1_k127_786468_22 1894.JOER01000087_gene3452 8.565e-86 299.0 COG0477@1|root,COG0477@2|Bacteria,2GKFJ@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - ko:K08225 - - - - ko00000,ko02000 2.A.1.38 - - MFS_3 MMS1_k127_786468_11 1229780.BN381_430040 1.802e-115 381.0 COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,3UWGK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM MMS1_k127_786468_16 1229780.BN381_210100 3.951e-103 342.0 COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,3UX17@52018|unclassified Actinobacteria (class) 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 MMS1_k127_786468_20 1283299.AUKG01000001_gene3159 1.231e-88 306.0 COG1680@1|root,COG1680@2|Bacteria,2GK3A@201174|Actinobacteria,4CSRU@84995|Rubrobacteria 84995|Rubrobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase MMS1_k127_786468_12 720554.Clocl_0124 1.776e-112 380.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WH8B@541000|Ruminococcaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C MMS1_k127_786468_44 1229780.BN381_100140 3.896e-27 117.0 COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,3UWRZ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N MMS1_k127_786468_47 1121877.JQKF01000007_gene975 9.775e-24 106.0 COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CN8W@84992|Acidimicrobiia 84992|Acidimicrobiia J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 MMS1_k127_786468_36 1229780.BN381_100142 1.824e-45 168.0 COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,3UWQD@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L Single-strand binding protein family ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944,GO:0097159,GO:1901363 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB MMS1_k127_786468_48 1348662.CARG_09500 5.702e-22 99.0 COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,22NGJ@1653|Corynebacteriaceae 201174|Actinobacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 MMS1_k127_786468_19 1229780.BN381_100144 4.981e-93 317.0 COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,3UW6F@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf MMS1_k127_786468_46 1313172.YM304_42670 1.391e-25 111.0 2CQNK@1|root,332VM@2|Bacteria,2HGHQ@201174|Actinobacteria,4CNEW@84992|Acidimicrobiia 84992|Acidimicrobiia S Family of unknown function (DUF5318) - - - - - - - - - - - - DUF5318 MMS1_k127_786468_49 1283283.ATXA01000037_gene2301 4.655e-19 100.0 COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria,4ESIA@85013|Frankiales 201174|Actinobacteria K transcriptional regulator PadR family - - - - - - - - - - - - PadR,Vir_act_alpha_C MMS1_k127_786468_5 1121877.JQKF01000017_gene209 9.614e-181 572.0 COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4CNE8@84992|Acidimicrobiia 84992|Acidimicrobiia I Myo-inositol-1-phosphate synthase ino1 - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth MMS1_k127_786468_41 1035308.AQYY01000001_gene3625 4.925e-35 139.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N,WHG MMS1_k127_786468_45 1168059.KB899087_gene4324 2.442e-26 113.0 2CWCM@1|root,32SZF@2|Bacteria,1N037@1224|Proteobacteria,2UCWU@28211|Alphaproteobacteria,3F1T6@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4260) - - - - - - - - - - - - DUF4260 MMS1_k127_786468_6 1996.JOFO01000007_gene4526 1.013e-150 491.0 COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4EHGF@85012|Streptosporangiales 201174|Actinobacteria J Probable RNA and SrmB- binding site of polymerase A pcnA - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd MMS1_k127_786468_52 1121877.JQKF01000017_gene202 2.37e-09 70.0 2B0G0@1|root,31STG@2|Bacteria,2HGDS@201174|Actinobacteria,4CNCA@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_786468_21 525909.Afer_0027 2.576e-88 311.0 COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4CN0A@84992|Acidimicrobiia 84992|Acidimicrobiia S Polysaccharide biosynthesis C-terminal domain - - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN MMS1_k127_786468_26 1313172.YM304_42740 2.791e-69 244.0 COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,4CN2K@84992|Acidimicrobiia 84992|Acidimicrobiia S Uncharacterised protein, DegV family COG1307 - - - - - - - - - - - - DegV MMS1_k127_786468_54 1121877.JQKF01000017_gene205 0.0002306 49.0 2BBMV@1|root,3255U@2|Bacteria,2HH3I@201174|Actinobacteria,4CP3I@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_786468_13 365528.KB891230_gene2032 2.902e-112 377.0 COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4ERUM@85013|Frankiales 201174|Actinobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384,ko:K03671 ko00450,ko04621,ko05418,map00450,map04621,map05418 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000,ko03110 - - iNJ661.Rv3913 Pyr_redox_2 MMS1_k127_786468_40 211114.JOEF01000003_gene2827 3.548e-36 140.0 COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4E4EG@85010|Pseudonocardiales 201174|Actinobacteria O Belongs to the thioredoxin family trxC GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0015037,GO:0015038,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016657,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0022900,GO:0030312,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071944,GO:0080007,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin MMS1_k127_786468_42 1121877.JQKF01000017_gene208 5.035e-34 146.0 COG3409@1|root,COG3409@2|Bacteria,2HG9Y@201174|Actinobacteria,4CN8M@84992|Acidimicrobiia 84992|Acidimicrobiia M Putative peptidoglycan binding domain - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - PG_binding_1 MMS1_k127_786468_24 1313172.YM304_42840 1.984e-76 266.0 COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4CMXK@84992|Acidimicrobiia 84992|Acidimicrobiia K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc MMS1_k127_786468_18 525909.Afer_2031 9.104e-98 325.0 COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CMSR@84992|Acidimicrobiia 84992|Acidimicrobiia D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 MMS1_k127_786468_39 1229780.BN381_60003 2.554e-37 148.0 COG0357@1|root,COG0357@2|Bacteria 2|Bacteria J rRNA methyltransferase activity rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB MMS1_k127_786468_33 1121877.JQKF01000017_gene194 3.43e-48 185.0 COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CN3J@84992|Acidimicrobiia 84992|Acidimicrobiia S Putative single-stranded nucleic acids-binding domain - - - ko:K06346 - - - - ko00000 - - - Jag_N,R3H MMS1_k127_786468_32 1121877.JQKF01000017_gene193 1.187e-53 200.0 COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CN42@84992|Acidimicrobiia 84992|Acidimicrobiia U 60Kd inner membrane protein - - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP MMS1_k127_786468_50 1313172.YM304_42890 3.01e-17 87.0 COG0759@1|root,COG0759@2|Bacteria,2HH1R@201174|Actinobacteria,4CP20@84992|Acidimicrobiia 84992|Acidimicrobiia S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic MMS1_k127_786468_53 656024.FsymDg_0004 1.546e-06 54.0 COG0594@1|root,COG0594@2|Bacteria 2|Bacteria J ribonuclease P activity rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 ko:K03536,ko:K08998 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P MMS1_k127_786468_51 471856.Jden_2558 1.632e-13 70.0 COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria 201174|Actinobacteria J Belongs to the bacterial ribosomal protein bL34 family rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 MMS1_k127_786468_17 525909.Afer_0001 1.135e-102 354.0 COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4CMQT@84992|Acidimicrobiia 84992|Acidimicrobiia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N MMS1_k127_786468_23 1313172.YM304_00020 6.261e-81 282.0 COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CN18@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA polymerase III beta subunit dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 MMS1_k127_786468_29 1229780.BN381_100169 1.141e-60 223.0 COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,3UWHW@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N MMS1_k127_786468_2 269800.Tfu_0006 3.246e-225 714.0 COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4EGRF@85012|Streptosporangiales 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim MMS1_k127_786468_0 525909.Afer_0006 4.939e-294 924.0 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CMSQ@84992|Acidimicrobiia 84992|Acidimicrobiia L DNA Topoisomerase IV - - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV MMS1_k127_786468_34 218284.CCDN010000001_gene1426 5.321e-48 179.0 COG2761@1|root,COG2761@2|Bacteria,1TZ1N@1239|Firmicutes,4HEBF@91061|Bacilli,1ZD4M@1386|Bacillus 91061|Bacilli Q dithiol-disulfide isomerase involved in polyketide biosynthesis frnE - 5.3.4.1 ko:K01829 - - - - ko00000,ko01000 - - - DSBA MMS1_k127_786468_10 1229780.BN381_60006 1.77e-116 390.0 COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,3UXF8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C MMS1_k127_786468_14 321955.AAGP01000001_gene3257 3.017e-111 378.0 COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4F8SH@85019|Brevibacteriaceae 201174|Actinobacteria S ATPases associated with a variety of cellular activities ybiT - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn,DLIC MMS1_k127_786468_3 649831.L083_2511 2.047e-191 613.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4D8ZV@85008|Micromonosporales 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran MMS1_k127_786468_1 590998.Celf_1725 4.929e-233 741.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4F0WR@85016|Cellulomonadaceae 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran MMS1_k127_786468_43 290399.Arth_3661 8.649e-30 125.0 COG0071@1|root,COG0071@2|Bacteria,2GQGQ@201174|Actinobacteria 201174|Actinobacteria O Belongs to the small heat shock protein (HSP20) family hspX GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564 - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 MMS1_k127_815179_4 396588.Tgr7_0251 2.748e-94 321.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 MMS1_k127_815179_8 222534.KB893729_gene5670 1.794e-28 118.0 COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4EVQI@85013|Frankiales 201174|Actinobacteria K Transcriptional regulator - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 MMS1_k127_815179_5 1123320.KB889698_gene9299 1.087e-83 303.0 COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria 201174|Actinobacteria E LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK MMS1_k127_815179_1 1313172.YM304_10760 1e-132 435.0 COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4CMR2@84992|Acidimicrobiia 84992|Acidimicrobiia M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase MMS1_k127_815179_3 1229780.BN381_10054 6.339e-126 411.0 COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,3UW6A@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Bacterial fructose-1,6-bisphosphatase, glpX-encoded glpX GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX MMS1_k127_815179_7 1380356.JNIK01000011_gene1767 3.627e-37 146.0 COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria,4ET4E@85013|Frankiales 201174|Actinobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS MMS1_k127_815179_9 1074451.CRL705_211 6.619e-10 70.0 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,4HKHS@91061|Bacilli,3F6I6@33958|Lactobacillaceae 91061|Bacilli C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N MMS1_k127_815179_0 525909.Afer_1795 1.878e-242 768.0 COG0055@1|root,COG0055@2|Bacteria,2GIY6@201174|Actinobacteria,4CMWB@84992|Acidimicrobiia 84992|Acidimicrobiia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N MMS1_k127_815179_6 1229780.BN381_10048 1.241e-62 226.0 COG0224@1|root,COG0224@2|Bacteria,2GJ7Q@201174|Actinobacteria,3UWAU@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt MMS1_k127_815179_2 1121877.JQKF01000003_gene1522 6.555e-130 419.0 COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CMTI@84992|Acidimicrobiia 84992|Acidimicrobiia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N MMS1_k127_846274_0 1121877.JQKF01000003_gene1462 1.117e-237 743.0 COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia 84992|Acidimicrobiia H Dehydratase family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD MMS1_k127_846274_14 1172188.KB911827_gene4376 4.24e-10 67.0 2FDZX@1|root,34604@2|Bacteria,2IN56@201174|Actinobacteria,4FH8N@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_846274_10 1122130.AUHN01000009_gene594 7.611e-49 187.0 COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria 201174|Actinobacteria S Protein of unknown function (DUF3048) C-terminal domain yerB - - - - - - - - - - - DUF3048,DUF3048_C MMS1_k127_846274_2 1229780.BN381_10094 4.18e-172 558.0 COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,3UW72@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey MMS1_k127_846274_1 1229780.BN381_10093 1.705e-177 568.0 COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,3UWA6@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase MMS1_k127_846274_13 710687.KI912270_gene1977 1.138e-21 107.0 COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,239Z5@1762|Mycobacteriaceae 201174|Actinobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln MMS1_k127_846274_11 1313172.YM304_33890 3.972e-48 184.0 COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria 201174|Actinobacteria S Esterase yvaK - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Hydrolase_4 MMS1_k127_846274_9 1282876.BAOK01000001_gene1422 1.609e-55 214.0 COG0477@1|root,COG2814@2|Bacteria,1QTY0@1224|Proteobacteria,2TXVS@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr MMS1_k127_846274_5 1313172.YM304_12640 4.575e-110 362.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4CMRY@84992|Acidimicrobiia 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short MMS1_k127_846274_12 479432.Sros_2780 2.362e-41 173.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EGFA@85012|Streptosporangiales 201174|Actinobacteria KLT PASTA pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase MMS1_k127_846274_3 1192034.CAP_4583 2.634e-164 544.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2YU7A@29|Myxococcales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 MMS1_k127_846274_6 1229780.BN381_10079 3.401e-96 329.0 COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,3UW6U@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans MMS1_k127_846274_7 555088.DealDRAFT_0271 2.406e-68 246.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42KYM@68298|Syntrophomonadaceae 186801|Clostridia H Aminotransferase class-V iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 MMS1_k127_846274_4 378806.STAUR_7791 3.091e-138 454.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42MDU@68525|delta/epsilon subdivisions,2WM9V@28221|Deltaproteobacteria,2YUA7@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS1_k127_846274_8 215803.DB30_0464 6.399e-60 223.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions 1224|Proteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_3 MMS1_k127_894343_36 1089545.KB913037_gene8534 6.864e-07 51.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4E1TD@85010|Pseudonocardiales 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_32 MMS1_k127_894343_29 446470.Snas_6348 2.366e-43 165.0 COG2423@1|root,COG2423@2|Bacteria,2IBFC@201174|Actinobacteria 201174|Actinobacteria E Pfam Ornithine cyclodeaminase mu-crystallin - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall MMS1_k127_894343_5 1110697.NCAST_34_01860 1.439e-176 578.0 COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4FUUF@85025|Nocardiaceae 201174|Actinobacteria S MMPL family - - - ko:K06994 - - - - ko00000 - - - MMPL MMS1_k127_894343_26 1394178.AWOO02000021_gene7286 1.05e-46 179.0 COG1309@1|root,COG1309@2|Bacteria,2INZP@201174|Actinobacteria,4EQ7E@85012|Streptosporangiales 201174|Actinobacteria K BetI-type transcriptional repressor, C-terminal - - - - - - - - - - - - TetR_C_6,TetR_N MMS1_k127_894343_16 1279019.ARQK01000042_gene2036 1.881e-72 263.0 COG0642@1|root,COG2206@1|root,COG2205@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T domain protein - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_4,PAS_9 MMS1_k127_894343_14 1380393.JHVP01000006_gene4071 1.536e-80 297.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales 201174|Actinobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF,GAF_2,GAF_3,GGDEF MMS1_k127_894343_10 314345.SPV1_05173 6.705e-101 348.0 COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria 1224|Proteobacteria T ggdef domain - - - - - - - - - - - - GGDEF,PAS_4,PAS_9,dCache_1 MMS1_k127_894343_1 1121017.AUFG01000006_gene1184 2.458e-233 728.0 COG3033@1|root,COG3033@2|Bacteria,2GKH3@201174|Actinobacteria,4FIY8@85021|Intrasporangiaceae 201174|Actinobacteria E Beta-eliminating lyase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase MMS1_k127_894343_33 479434.Sthe_0599 1.055e-28 121.0 COG2318@1|root,COG2318@2|Bacteria,2G98Y@200795|Chloroflexi,27YQK@189775|Thermomicrobia 189775|Thermomicrobia S DinB family - - - - - - - - - - - - DinB MMS1_k127_894343_15 1206726.BAFV01000022_gene1477 9.651e-79 274.0 COG0454@1|root,COG0454@2|Bacteria,2IAEP@201174|Actinobacteria,4G6CI@85025|Nocardiaceae 201174|Actinobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 MMS1_k127_894343_27 1121877.JQKF01000003_gene1472 7.952e-45 173.0 COG0682@1|root,COG0682@2|Bacteria,2HGGR@201174|Actinobacteria,4CNDX@84992|Acidimicrobiia 84992|Acidimicrobiia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - - - - - - - - - - LGT MMS1_k127_894343_32 525246.HMPREF0058_1297 1.947e-29 132.0 COG0791@1|root,COG0791@2|Bacteria,2GIWB@201174|Actinobacteria,4D43E@85005|Actinomycetales 201174|Actinobacteria M NlpC P60 family protein - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60,SH3_3 MMS1_k127_894343_7 1121877.JQKF01000003_gene1497 2.287e-143 462.0 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4CNND@84992|Acidimicrobiia 84992|Acidimicrobiia G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.24,4.1.3.25,4.1.3.34 ko:K01644,ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020 M00346,M00373,M00376 R00237,R00362,R00473,R00934 RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI MMS1_k127_894343_8 351607.Acel_0768 4.147e-139 452.0 COG2042@1|root,COG3376@2|Bacteria,2GJZB@201174|Actinobacteria,4ETVR@85013|Frankiales 201174|Actinobacteria S Belongs to the NiCoT transporter (TC 2.A.52) family nicT - - ko:K07241 - - - - ko00000,ko02000 2.A.52.1 - - NicO MMS1_k127_894343_2 1229780.BN381_210057 4.675e-201 639.0 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,3UX9W@52018|unclassified Actinobacteria (class) 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.1,1.3.8.12 ko:K00248,ko:K14448 ko00071,ko00280,ko00630,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00630,map00650,map01100,map01110,map01120,map01200,map01212 M00373 R01175,R01178,R02661,R03172,R04751,R09293 RC00052,RC00068,RC00076,RC00120,RC00148,RC02483 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_894343_25 1121877.JQKF01000001_gene1300 6.505e-47 172.0 2E3FZ@1|root,31FAR@2|Bacteria,2HGRD@201174|Actinobacteria,4CNTW@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_894343_12 1313172.YM304_14250 8.406e-87 289.0 COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4CMYB@84992|Acidimicrobiia 84992|Acidimicrobiia I MaoC like domain - - - - - - - - - - - - MaoC_dehydratas MMS1_k127_894343_21 743718.Isova_0538 6.012e-53 199.0 COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4F48U@85017|Promicromonosporaceae 201174|Actinobacteria L FES mutY GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD MMS1_k127_894343_30 1127134.NOCYR_2414 1.56e-35 143.0 COG1853@1|root,COG1853@2|Bacteria,2GPJS@201174|Actinobacteria,4G0FZ@85025|Nocardiaceae 201174|Actinobacteria S Flavin reductase like domain - - - ko:K16048 ko00984,ko01100,map00984,map01100 - R09819 RC00236 ko00000,ko00001,ko01000 - - - Flavin_Reduct MMS1_k127_894343_3 1121926.AXWO01000036_gene4009 1.203e-185 621.0 COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4EY6S@85014|Glycomycetales 201174|Actinobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N MMS1_k127_894343_0 1121877.JQKF01000001_gene1306 5.537e-244 764.0 COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4CMQU@84992|Acidimicrobiia 84992|Acidimicrobiia O Uncharacterized protein family (UPF0051) - - - ko:K09014 - - - - ko00000 - - - UPF0051 MMS1_k127_894343_34 1229780.BN381_210073 1.056e-23 106.0 2FF8Q@1|root,3476J@2|Bacteria,2H7PN@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS1_k127_894343_17 749927.AMED_4997 1.503e-71 250.0 COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4E086@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase carnithine racemase echA21 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 MMS1_k127_894343_22 1123389.ATXJ01000013_gene923 3.079e-51 198.0 COG0719@1|root,COG0719@2|Bacteria,1WJ1E@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O TIGRFAM FeS assembly protein SufD - - - ko:K09015 - - - - ko00000 - - - UPF0051 MMS1_k127_894343_35 935863.AWZR01000007_gene352 1.461e-15 82.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SG29@1236|Gammaproteobacteria,1X6VK@135614|Xanthomonadales 135614|Xanthomonadales P Benzene 1,2-dioxygenase bedB - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske MMS1_k127_894343_18 1123269.NX02_24695 3.459e-66 234.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2K0E3@204457|Sphingomonadales 204457|Sphingomonadales O ABC-type transport system involved in Fe-S cluster assembly, ATPase component sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran MMS1_k127_894343_19 1121877.JQKF01000002_gene1746 5.114e-58 218.0 COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4CN74@84992|Acidimicrobiia 84992|Acidimicrobiia K Cell envelope-related transcriptional attenuator domain - - - - - - - - - - - - LytR_cpsA_psr MMS1_k127_894343_24 1121877.JQKF01000001_gene1319 8.034e-49 181.0 COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4CN20@84992|Acidimicrobiia 84992|Acidimicrobiia C NifU-like N terminal domain - - - ko:K04488 - - - - ko00000 - - - NifU_N MMS1_k127_894343_9 383372.Rcas_0306 2.28e-131 437.0 COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi,3766K@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 MMS1_k127_894343_11 525909.Afer_0566 9.554e-97 322.0 COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4CMZ6@84992|Acidimicrobiia 84992|Acidimicrobiia O FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran MMS1_k127_894343_13 1229780.BN381_210088 2.663e-83 282.0 COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,3UXGK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B MMS1_k127_894343_6 1229780.BN381_210093 1.362e-144 467.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,3UXCB@52018|unclassified Actinobacteria (class) 201174|Actinobacteria I Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS1_k127_894343_31 1229780.BN381_210096 3.945e-34 140.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity ycjY GO:0008150,GO:0009987,GO:0051301 - ko:K01990,ko:K06889 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - DLH,Hydrolase_4,Peptidase_S15 MMS1_k127_894343_20 525909.Afer_0711 2.13e-53 194.0 COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria 201174|Actinobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv0414c TMP-TENI MMS1_k127_894343_28 749414.SBI_09481 1.175e-43 164.0 COG1959@1|root,COG1959@2|Bacteria,2INF3@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 MMS1_k127_894343_23 1122609.AUGT01000011_gene3539 8.129e-50 183.0 COG0328@1|root,COG0328@2|Bacteria,2GK53@201174|Actinobacteria,4DR5Z@85009|Propionibacteriales 201174|Actinobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DUF4440,RNase_H MMS1_k127_894343_4 1229780.BN381_210107 1.239e-178 571.0 COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,3UWCV@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim MMS1_k127_911164_41 525909.Afer_0701 1.71e-67 243.0 29BBV@1|root,2ZYA6@2|Bacteria,2ICWN@201174|Actinobacteria,4CNPC@84992|Acidimicrobiia 84992|Acidimicrobiia S Phosphodiester glycosidase - - - - - - - - - - - - NAGPA MMS1_k127_911164_12 1009370.ALO_03081 5.685e-190 619.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4H28C@909932|Negativicutes 909932|Negativicutes L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C MMS1_k127_911164_9 326424.FRAAL1150 5.413e-215 678.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4ERBR@85013|Frankiales 201174|Actinobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase MMS1_k127_911164_17 469371.Tbis_0624 5.817e-148 478.0 COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4DY36@85010|Pseudonocardiales 201174|Actinobacteria F IMP dehydrogenase GMP reductase guaB3 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - IMPDH MMS1_k127_911164_76 1229780.BN381_130040 5.315e-32 136.0 COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria,3UWZK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L NUDIX domain - - - - - - - - - - - - NUDIX MMS1_k127_911164_7 358823.DF19_18595 1.281e-228 729.0 COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria 201174|Actinobacteria F Drug exporters of the RND superfamily - - - ko:K06994 - - - - ko00000 - - - MMPL MMS1_k127_911164_95 1206741.BAFX01000129_gene2024 6.996e-05 53.0 COG1309@1|root,COG1309@2|Bacteria,2I9S0@201174|Actinobacteria,4G157@85025|Nocardiaceae 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS1_k127_911164_2 1463856.JOHY01000001_gene518 0.0 1092.0 COG2838@1|root,COG2838@2|Bacteria,2GJ1C@201174|Actinobacteria 201174|Actinobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH MMS1_k127_911164_5 525909.Afer_0444 1.074e-256 800.0 COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4CMU0@84992|Acidimicrobiia 84992|Acidimicrobiia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 MMS1_k127_911164_68 525909.Afer_0443 4.665e-42 157.0 COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4CN66@84992|Acidimicrobiia 84992|Acidimicrobiia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 MMS1_k127_911164_55 309801.trd_A0007 2.674e-51 194.0 COG0259@1|root,COG0259@2|Bacteria,2G8DA@200795|Chloroflexi,27Y9H@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) - - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx MMS1_k127_911164_22 1229780.BN381_130036 4.788e-103 350.0 COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,3UWA4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Acetyltransf_1,Peptidase_M22 MMS1_k127_911164_83 471852.Tcur_4262 2.347e-25 112.0 COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4EJP4@85012|Streptosporangiales 201174|Actinobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 MMS1_k127_911164_85 1500259.JQLD01000004_gene1276 1.685e-22 109.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,4BASV@82115|Rhizobiaceae 28211|Alphaproteobacteria O COG1214 Inactive homolog of metal-dependent proteases yeaZ - 2.3.1.234 ko:K01409,ko:K14742 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 MMS1_k127_911164_82 485916.Dtox_3739 1.919e-25 111.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised P-loop hydrolase UPF0079 ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE MMS1_k127_911164_72 290512.Paes_0339 1.826e-39 154.0 COG1573@1|root,COG1573@2|Bacteria,1FDUS@1090|Chlorobi 1090|Chlorobi L TIGRFAM phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG MMS1_k127_911164_28 1313172.YM304_08920 4.573e-88 306.0 COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4CN11@84992|Acidimicrobiia 84992|Acidimicrobiia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N MMS1_k127_911164_86 1313172.YM304_08850 2.852e-21 99.0 COG0736@1|root,COG0736@2|Bacteria,2HGFC@201174|Actinobacteria,4CND0@84992|Acidimicrobiia 84992|Acidimicrobiia I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS MMS1_k127_911164_13 1160718.SU9_16872 5.36e-182 587.0 COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria 201174|Actinobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iNJ661.Rv3436c GATase_6,SIS MMS1_k127_911164_29 519989.ECTPHS_07022 3.425e-87 309.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1WW1H@135613|Chromatiales 135613|Chromatiales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV MMS1_k127_911164_65 1229780.BN381_130024 3.524e-44 165.0 COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,3UWN9@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 MMS1_k127_911164_51 351607.Acel_0341 1.736e-56 201.0 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4ESPF@85013|Frankiales 201174|Actinobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 MMS1_k127_911164_59 471852.Tcur_4288 3.957e-49 186.0 COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4EHNP@85012|Streptosporangiales 201174|Actinobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 MMS1_k127_911164_73 1121877.JQKF01000009_gene522 5.588e-39 148.0 COG0203@1|root,COG0203@2|Bacteria,2IHV2@201174|Actinobacteria,4CN4I@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 MMS1_k127_911164_26 593907.Celgi_0843 2.446e-92 312.0 COG0202@1|root,COG0202@2|Bacteria,2GJJ5@201174|Actinobacteria,4F0UI@85016|Cellulomonadaceae 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L MMS1_k127_911164_31 525909.Afer_0425 1.546e-78 273.0 COG0522@1|root,COG0522@2|Bacteria,2GIRX@201174|Actinobacteria,4CN4S@84992|Acidimicrobiia 84992|Acidimicrobiia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 MMS1_k127_911164_50 36809.MAB_3772c 3.427e-57 203.0 COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,238NX@1762|Mycobacteriaceae 201174|Actinobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 MMS1_k127_911164_57 1229780.BN381_450074 8.475e-50 179.0 COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,3UWMD@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 MMS1_k127_911164_91 908337.HMPREF9257_0112 1.469e-13 70.0 COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,4HR2X@91061|Bacilli,27EZF@186827|Aerococcaceae 91061|Bacilli J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 MMS1_k127_911164_74 525909.Afer_0421 7.634e-35 136.0 COG0361@1|root,COG0361@2|Bacteria,2IQ4B@201174|Actinobacteria,4CNX6@84992|Acidimicrobiia 84992|Acidimicrobiia J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a MMS1_k127_911164_96 345341.KUTG_00558 0.0001064 52.0 COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria,4E6H3@85010|Pseudonocardiales 201174|Actinobacteria S Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Pyridox_ox_2 MMS1_k127_911164_30 351607.Acel_0516 5.689e-79 277.0 COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria,4EXC4@85013|Frankiales 201174|Actinobacteria T histidine kinase, dimerisation and phosphoacceptor region devS GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 ko:K07682 ko02020,map02020 M00482 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3 MMS1_k127_911164_47 1229780.BN381_10300 2.061e-62 222.0 COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,3UX9E@52018|unclassified Actinobacteria (class) 201174|Actinobacteria T helix_turn_helix, Lux Regulon devR GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0009405,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0016020,GO:0018995,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030312,GO:0030430,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032502,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0036293,GO:0043656,GO:0043657,GO:0044174,GO:0044215,GO:0044216,GO:0044217,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0070482,GO:0071944,GO:0072493,GO:0080090,GO:0080134,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1902882,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K02479,ko:K07695 ko02020,map02020 M00482 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg MMS1_k127_911164_25 525909.Afer_0420 2.377e-98 329.0 COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,4CN1I@84992|Acidimicrobiia 84992|Acidimicrobiia J Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 MMS1_k127_911164_48 525909.Afer_0419 6.762e-62 219.0 COG0563@1|root,COG0563@2|Bacteria,2GJ7T@201174|Actinobacteria,4CMZ1@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid MMS1_k127_911164_15 1121877.JQKF01000009_gene529 1.326e-164 527.0 COG0201@1|root,COG0201@2|Bacteria,2GJ26@201174|Actinobacteria,4CMWZ@84992|Acidimicrobiia 84992|Acidimicrobiia U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY MMS1_k127_911164_54 1229780.BN381_450078 1.704e-52 189.0 COG0200@1|root,COG0200@2|Bacteria,2II6M@201174|Actinobacteria,3UWM5@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A MMS1_k127_911164_87 1313172.YM304_08430 1.057e-17 91.0 COG1841@1|root,COG1841@2|Bacteria,2HGDQ@201174|Actinobacteria,4CNC3@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal protein L30p/L7e rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 MMS1_k127_911164_36 1121877.JQKF01000009_gene532 2.161e-71 253.0 COG0098@1|root,COG0098@2|Bacteria,2GJW8@201174|Actinobacteria,4CN34@84992|Acidimicrobiia 84992|Acidimicrobiia J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C MMS1_k127_911164_71 661478.OP10G_0596 1.261e-39 150.0 COG0256@1|root,COG0256@2|Bacteria 2|Bacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p MMS1_k127_911164_43 1313172.YM304_08400 2.717e-66 230.0 COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4CMZ3@84992|Acidimicrobiia 84992|Acidimicrobiia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 MMS1_k127_911164_58 1451189.CFAL_10010 2.987e-49 181.0 COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria,22MWH@1653|Corynebacteriaceae 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 MMS1_k127_911164_80 390989.JOEG01000009_gene1218 1.199e-26 111.0 COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4DG1P@85008|Micromonosporales 201174|Actinobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 MMS1_k127_911164_32 1229780.BN381_450085 4.962e-78 269.0 COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,3UW6C@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C MMS1_k127_911164_93 44454.NF84_20480 8.296e-11 71.0 COG0198@1|root,COG0198@2|Bacteria,2IKP2@201174|Actinobacteria,23A30@1762|Mycobacteriaceae 201174|Actinobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 MMS1_k127_911164_40 525909.Afer_0408 9.566e-68 233.0 COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4CMZN@84992|Acidimicrobiia 84992|Acidimicrobiia J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 MMS1_k127_911164_77 1313172.YM304_08340 1.228e-29 119.0 COG0186@1|root,COG0186@2|Bacteria,2IQ68@201174|Actinobacteria,4CN9S@84992|Acidimicrobiia 84992|Acidimicrobiia J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 MMS1_k127_911164_88 1229780.BN381_450089 1.742e-15 80.0 COG0255@1|root,COG0255@2|Bacteria,2IQ6V@201174|Actinobacteria,3UWTS@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 MMS1_k127_911164_38 1121877.JQKF01000009_gene541 1.951e-69 237.0 COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4CN0S@84992|Acidimicrobiia 84992|Acidimicrobiia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 MMS1_k127_911164_21 1313172.YM304_08310 1.277e-105 351.0 COG0092@1|root,COG0092@2|Bacteria,2GKF1@201174|Actinobacteria,4CMU9@84992|Acidimicrobiia 84992|Acidimicrobiia J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C MMS1_k127_911164_67 1313172.YM304_08300 1.547e-42 164.0 COG0091@1|root,COG0091@2|Bacteria,2IM3J@201174|Actinobacteria,4CNBP@84992|Acidimicrobiia 84992|Acidimicrobiia J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 MMS1_k127_911164_62 1121877.JQKF01000009_gene544 8.113e-47 169.0 COG0185@1|root,COG0185@2|Bacteria,2IKMS@201174|Actinobacteria,4CN5R@84992|Acidimicrobiia 84992|Acidimicrobiia J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 MMS1_k127_911164_18 1229780.BN381_450094 3.689e-134 434.0 COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,3UWDY@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C MMS1_k127_911164_81 1229780.BN381_450095 3.413e-26 110.0 COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,3UWUI@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 MMS1_k127_911164_44 1313172.YM304_08260 7.543e-66 231.0 COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4CN29@84992|Acidimicrobiia 84992|Acidimicrobiia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 MMS1_k127_911164_34 1313172.YM304_08250 9.534e-77 264.0 COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4CMZP@84992|Acidimicrobiia 84992|Acidimicrobiia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 MMS1_k127_911164_66 525909.Afer_0397 3.64e-43 159.0 COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4CN6W@84992|Acidimicrobiia 84992|Acidimicrobiia J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 MMS1_k127_911164_8 525909.Afer_0396 8.487e-217 677.0 COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CMSE@84992|Acidimicrobiia 84992|Acidimicrobiia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 MMS1_k127_911164_3 1121877.JQKF01000009_gene551 0.0 1064.0 COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4CMTM@84992|Acidimicrobiia 84992|Acidimicrobiia J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 MMS1_k127_911164_39 888052.HMPREF9006_1746 7.42e-69 243.0 COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,4D4K3@85005|Actinomycetales 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 MMS1_k127_911164_45 1122138.AQUZ01000015_gene6766 3.481e-65 224.0 COG0048@1|root,COG0048@2|Bacteria,2IHUF@201174|Actinobacteria,4DQR6@85009|Propionibacteriales 201174|Actinobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 MMS1_k127_911164_0 525909.Afer_0392 0.0 1677.0 COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4CMT4@84992|Acidimicrobiia 84992|Acidimicrobiia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 MMS1_k127_911164_1 525909.Afer_0391 0.0 1593.0 COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4CMVP@84992|Acidimicrobiia 84992|Acidimicrobiia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 MMS1_k127_911164_61 106370.Francci3_0572 3.161e-47 173.0 COG0222@1|root,COG0222@2|Bacteria,2IKNW@201174|Actinobacteria,4ESPE@85013|Frankiales 201174|Actinobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N MMS1_k127_911164_63 1313172.YM304_07930 2.316e-45 172.0 COG0244@1|root,COG0244@2|Bacteria,2GM0V@201174|Actinobacteria,4CN6B@84992|Acidimicrobiia 84992|Acidimicrobiia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 MMS1_k127_911164_27 1121877.JQKF01000009_gene558 2.712e-90 304.0 COG0081@1|root,COG0081@2|Bacteria,2GM51@201174|Actinobacteria,4CMU4@84992|Acidimicrobiia 84992|Acidimicrobiia J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 MMS1_k127_911164_53 1121877.JQKF01000009_gene559 2.425e-54 198.0 COG0080@1|root,COG0080@2|Bacteria,2IFCK@201174|Actinobacteria,4CN3H@84992|Acidimicrobiia 84992|Acidimicrobiia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N MMS1_k127_911164_49 1229780.BN381_350058 1.07e-57 207.0 COG0250@1|root,COG0250@2|Bacteria,2GJFW@201174|Actinobacteria,3UWJ1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria K Participates in transcription elongation, termination and antitermination nusG GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - NusG MMS1_k127_911164_89 1229780.BN381_350057 3.872e-14 76.0 COG0690@1|root,COG0690@2|Bacteria 2|Bacteria U P-P-bond-hydrolysis-driven protein transmembrane transporter activity secE GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE MMS1_k127_911164_84 525909.Afer_0383 7.564e-23 99.0 COG0267@1|root,COG0267@2|Bacteria,2HH2Z@201174|Actinobacteria,4CP34@84992|Acidimicrobiia 84992|Acidimicrobiia J Ribosomal protein L33 - - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 MMS1_k127_911164_64 1313172.YM304_07840 1.898e-44 167.0 COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria,4CN6Q@84992|Acidimicrobiia 84992|Acidimicrobiia M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 MMS1_k127_911164_35 525909.Afer_0380 7.213e-74 270.0 2AMJ0@1|root,31CER@2|Bacteria,2I3ZG@201174|Actinobacteria,4CNHF@84992|Acidimicrobiia 84992|Acidimicrobiia - - - - - - - - - - - - - - - MMS1_k127_911164_60 525909.Afer_0379 1.059e-47 175.0 COG1666@1|root,COG1666@2|Bacteria,2IFIU@201174|Actinobacteria,4CN1Y@84992|Acidimicrobiia 84992|Acidimicrobiia S Protein of unknown function (DUF520) - - - ko:K09767 - - - - ko00000 - - - DUF520 MMS1_k127_911164_69 1313172.YM304_05710 3.725e-40 165.0 COG1808@1|root,COG1808@2|Bacteria 2|Bacteria S Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 MMS1_k127_911164_79 1121877.JQKF01000003_gene1563 9.89e-28 118.0 COG2246@1|root,COG2246@2|Bacteria,2HGRJ@201174|Actinobacteria,4CNUB@84992|Acidimicrobiia 84992|Acidimicrobiia S GtrA-like protein - - - - - - - - - - - - GtrA MMS1_k127_911164_24 525909.Afer_1834 1.024e-100 337.0 COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4CMRR@84992|Acidimicrobiia 84992|Acidimicrobiia I Thioesterase-like superfamily - - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 MMS1_k127_911164_90 518766.Rmar_2523 1.051e-13 77.0 COG2318@1|root,COG2318@2|Bacteria,4NNQI@976|Bacteroidetes 976|Bacteroidetes S hydrolase - - - - - - - - - - - - DinB_2 MMS1_k127_911164_11 525909.Afer_1835 8.938e-208 653.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CMS9@84992|Acidimicrobiia 84992|Acidimicrobiia C Citrate synthase, C-terminal domain - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt MMS1_k127_911164_52 404589.Anae109_0527 8.969e-56 215.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42NDS@68525|delta/epsilon subdivisions,2WJDE@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DNA recombination protein RmuC - - - ko:K09760 - - - - ko00000 - - - RmuC MMS1_k127_911164_75 1121877.JQKF01000010_gene689 4.359e-34 139.0 COG0704@1|root,COG0704@2|Bacteria,2HGEH@201174|Actinobacteria,4CNCK@84992|Acidimicrobiia 84992|Acidimicrobiia P PhoU domain - - - ko:K02039 - - - - ko00000 - - - PhoU MMS1_k127_911164_19 443255.SCLAV_1812 7.661e-131 427.0 COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3708c Semialdhyde_dh,Semialdhyde_dhC MMS1_k127_911164_14 1121877.JQKF01000011_gene381 6.393e-173 550.0 COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CMX1@84992|Acidimicrobiia 84992|Acidimicrobiia E ACT domain ask - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 MMS1_k127_911164_78 1463903.JOIZ01000034_gene4512 5.717e-29 124.0 COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria 201174|Actinobacteria O Peptidyl-prolyl cis-trans isomerase fkbP - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C MMS1_k127_911164_42 1229780.BN381_50060 8.441e-67 231.0 COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,3UWKX@52018|unclassified Actinobacteria (class) 201174|Actinobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase MMS1_k127_911164_94 1121877.JQKF01000018_gene2523 1.237e-08 64.0 COG4242@1|root,COG4242@2|Bacteria,2HGPS@201174|Actinobacteria,4CNS6@84992|Acidimicrobiia 84992|Acidimicrobiia E Peptidase family S51 - - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 MMS1_k127_911164_23 1313172.YM304_38120 7.004e-102 338.0 COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4CNMA@84992|Acidimicrobiia 84992|Acidimicrobiia I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N MMS1_k127_911164_4 103733.JNYO01000029_gene804 8.319e-275 863.0 COG2185@1|root,COG2185@2|Bacteria,2I2N3@201174|Actinobacteria,4DZXB@85010|Pseudonocardiales 201174|Actinobacteria I Methylmalonyl-CoA mutase meaA - 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase MMS1_k127_911164_6 525909.Afer_0231 1.861e-256 798.0 COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4CMPB@84992|Acidimicrobiia 84992|Acidimicrobiia I Carboxyl transferase domain - - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans MMS1_k127_911164_56 1229780.BN381_150047 4.788e-51 184.0 COG0346@1|root,COG0346@2|Bacteria,2IIPR@201174|Actinobacteria,3UWVQ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria E Glyoxalase-like domain mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 MMS1_k127_911164_10 1313172.YM304_37120 1.062e-208 664.0 COG0604@1|root,COG0604@2|Bacteria,2GKFF@201174|Actinobacteria,4CMSB@84992|Acidimicrobiia 84992|Acidimicrobiia C Zinc-binding dehydrogenase - - 1.3.1.86 ko:K17829 ko00650,ko01120,ko01130,ko01200,map00650,map01120,map01130,map01200 - R09738 RC00076 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS1_k127_911164_16 1121877.JQKF01000011_gene378 9.653e-159 516.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4CMTP@84992|Acidimicrobiia 84992|Acidimicrobiia I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N MMS1_k127_911164_92 266835.14027353 6.359e-11 72.0 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,43KDI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 MMS1_k127_911164_33 258533.BN977_02065 1.881e-77 269.0 COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria,2362A@1762|Mycobacteriaceae 201174|Actinobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA MMS1_k127_911164_37 1479623.JHEL01000015_gene1375 1.795e-69 242.0 COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4FM54@85023|Microbacteriaceae 201174|Actinobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 MMS1_k127_911164_20 1229780.BN381_150040 7.161e-107 366.0 COG2812@1|root,COG2812@2|Bacteria,2GJKA@201174|Actinobacteria,3UWAK@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 MMS1_k127_911164_70 1122609.AUGT01000005_gene1828 5.35e-40 158.0 2BIFQ@1|root,32CNA@2|Bacteria,2IN70@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - ## 2097 queries scanned ## Total time (seconds): 157.16114354133606 ## Rate: 13.34 q/s