## Fri Nov 15 20:54:55 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin16/MMS_1_bin.47.fa -m mmseqs --itype genome -o MMS_1_bin.47 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_1_bin.47 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS1_k127_100376_3	1265505.ATUG01000001_gene4413	1.89e-86	292.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_100376_2	1499967.BAYZ01000013_gene6463	4.128e-101	337.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red
MMS1_k127_100376_4	1479237.JMLY01000001_gene1472	3.567e-66	244.0	COG2199@1|root,COG3322@1|root,COG3322@2|Bacteria,COG3706@2|Bacteria,1R8M0@1224|Proteobacteria,1S0A3@1236|Gammaproteobacteria,46D99@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GGDEF
MMS1_k127_100376_5	1196322.A370_04802	3.939e-46	169.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,36JYV@31979|Clostridiaceae	186801|Clostridia	C	Desulfoferrodoxin ferrous iron-binding	dfx	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016721,GO:0019430,GO:0022900,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
MMS1_k127_100376_0	697303.Thewi_2495	3.633e-158	514.0	COG0249@1|root,COG0249@2|Bacteria,1UVM0@1239|Firmicutes,24ETT@186801|Clostridia	186801|Clostridia	L	PFAM DNA mismatch repair protein MutS	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
MMS1_k127_100376_1	697303.Thewi_2496	1.048e-134	439.0	COG0249@1|root,COG0249@2|Bacteria,1UYBJ@1239|Firmicutes,249T9@186801|Clostridia,42HQ4@68295|Thermoanaerobacterales	186801|Clostridia	L	SMART DNA mismatch repair protein MutS, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
MMS1_k127_1006891_6	1123274.KB899409_gene627	3.373e-32	128.0	COG4109@1|root,COG4109@2|Bacteria,2J8TR@203691|Spirochaetes	203691|Spirochaetes	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_N
MMS1_k127_1006891_3	1480694.DC28_04205	1.436e-79	267.0	COG1905@1|root,COG1905@2|Bacteria,2J7IH@203691|Spirochaetes	203691|Spirochaetes	C	Respiratory-chain NADH dehydrogenase 24 Kd subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
MMS1_k127_1006891_5	744872.Spica_2776	1.164e-43	166.0	COG0642@1|root,COG2205@2|Bacteria,2J8FP@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
MMS1_k127_1006891_4	573413.Spirs_3689	1.824e-46	170.0	COG3411@1|root,COG3411@2|Bacteria,2J7XQ@203691|Spirochaetes	203691|Spirochaetes	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS1_k127_1006891_0	1307761.L21SP2_0275	1.101e-291	904.0	COG1894@1|root,COG1894@2|Bacteria,2J5MT@203691|Spirochaetes	203691|Spirochaetes	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
MMS1_k127_1006891_1	889378.Spiaf_2409	3.047e-276	859.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6WY@203691|Spirochaetes	203691|Spirochaetes	C	Iron only hydrogenase large subunit, C-terminal domain	hymC	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,NADH-G_4Fe-4S_3
MMS1_k127_1006891_8	572544.Ilyop_1464	8.885e-11	70.0	COG0664@1|root,COG0664@2|Bacteria,37ARW@32066|Fusobacteria	32066|Fusobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS1_k127_1006891_2	665571.STHERM_c00340	1.695e-172	552.0	COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS1_k127_1006891_7	158189.SpiBuddy_1228	1.147e-30	127.0	COG0703@1|root,COG0703@2|Bacteria,2J7UD@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
MMS1_k127_1007257_2	1536775.H70737_05195	3.918e-21	94.0	COG1653@1|root,COG1653@2|Bacteria,1TR5P@1239|Firmicutes,4HAFJ@91061|Bacilli,26S5W@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1
MMS1_k127_1007257_0	1195236.CTER_1206	5.036e-114	375.0	COG0395@1|root,COG0395@2|Bacteria,1TS9S@1239|Firmicutes,24BF3@186801|Clostridia	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_1007257_1	1195236.CTER_1207	2.795e-109	360.0	COG4209@1|root,COG4209@2|Bacteria,1TT63@1239|Firmicutes,25C4W@186801|Clostridia,3WSB3@541000|Ruminococcaceae	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_100821_0	1382359.JIAL01000001_gene240	1.2e-48	182.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_100821_1	573413.Spirs_2984	7.961e-34	134.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	trxM1	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.8,5.3.4.1	ko:K01829,ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
MMS1_k127_100821_2	545694.TREPR_3767	8.492e-08	63.0	2920H@1|root,2ZPJT@2|Bacteria,2J5PN@203691|Spirochaetes	203691|Spirochaetes	S	Pilus assembly protein PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
MMS1_k127_1015638_0	1232453.BAIF02000013_gene3259	1.6e-128	421.0	COG3507@1|root,COG3507@2|Bacteria,1TR04@1239|Firmicutes,24ATC@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Glyco_hydro_43
MMS1_k127_1018410_0	573413.Spirs_0950	0.0	2209.0	COG0086@1|root,COG0086@2|Bacteria,2J5S7@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS1_k127_1018410_1	1123274.KB899411_gene3119	2.835e-206	645.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS1_k127_1021814_0	573413.Spirs_0095	3.431e-72	253.0	COG0515@1|root,COG0515@2|Bacteria,2J6N6@203691|Spirochaetes	203691|Spirochaetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMS1_k127_1021814_2	1167006.UWK_02681	1.467e-09	65.0	COG1716@1|root,COG2200@1|root,COG1716@2|Bacteria,COG2200@2|Bacteria,1R86G@1224|Proteobacteria,42ZP9@68525|delta/epsilon subdivisions,2WV3X@28221|Deltaproteobacteria,2MN95@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA
MMS1_k127_1021814_1	290399.Arth_2805	6.428e-53	199.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,1W80Q@1268|Micrococcaceae	201174|Actinobacteria	E	Succinyl-diaminopimelate desuccinylase	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS1_k127_10306_0	889378.Spiaf_2336	1.199e-68	244.0	COG0210@1|root,COG0210@2|Bacteria,2J7FY@203691|Spirochaetes	203691|Spirochaetes	L	Participates in both transcription termination and antitermination	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C
MMS1_k127_10306_2	1242864.D187_009536	0.0002602	51.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42Z45@68525|delta/epsilon subdivisions,2WTWB@28221|Deltaproteobacteria,2YW9J@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4
MMS1_k127_10306_1	1278073.MYSTI_03895	5.429e-40	162.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42SA7@68525|delta/epsilon subdivisions,2WNRU@28221|Deltaproteobacteria,2YU91@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
MMS1_k127_1033120_1	1304284.L21TH_0716	3.971e-102	346.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_1033120_0	331678.Cphamn1_2464	7.977e-231	736.0	COG0370@1|root,COG0370@2|Bacteria,1FDFB@1090|Chlorobi	1090|Chlorobi	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
MMS1_k127_1037371_5	1307761.L21SP2_0842	2.343e-33	132.0	COG0745@1|root,COG0745@2|Bacteria	1307761.L21SP2_0842|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1037371_4	1307761.L21SP2_0841	2.582e-44	174.0	COG3920@1|root,COG3920@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2
MMS1_k127_1037371_2	1307761.L21SP2_3480	1.201e-89	331.0	COG0457@1|root,COG0457@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1037371_3	555088.DealDRAFT_2219	4.078e-59	216.0	COG1015@1|root,COG1015@2|Bacteria,1UJAM@1239|Firmicutes,25EZP@186801|Clostridia	186801|Clostridia	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
MMS1_k127_1037371_0	338966.Ppro_1408	9.158e-166	544.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RGKE@1224|Proteobacteria,42QA9@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF,GAF_2,Guanylate_cyc,HATPase_c,HD_5,HisKA,dCache_1
MMS1_k127_1037371_1	1511.CLOST_0496	1.586e-115	389.0	COG0834@1|root,COG3437@1|root,COG0834@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	2.7.13.3,2.7.7.65,4.6.1.1	ko:K01768,ko:K02030,ko:K03415,ko:K07777,ko:K18967	ko00230,ko02020,ko02025,ko02030,ko04113,ko04213,map00230,map02020,map02025,map02030,map04113,map04213	M00236,M00478,M00506,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022,ko02035	3.A.1.3,9.B.34.1.1	-	-	CheW,GGDEF,PAS_3,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_1043138_18	744872.Spica_2016	1.465e-15	78.0	COG2127@1|root,COG2127@2|Bacteria,2J8RX@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
MMS1_k127_1043138_15	742818.HMPREF9451_00333	3.614e-22	98.0	COG2983@1|root,COG2983@2|Bacteria	2|Bacteria	S	Putative zinc- or iron-chelating domain	ycgN	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMS1_k127_1043138_1	744872.Spica_1315	4.408e-128	434.0	COG0457@1|root,COG3391@1|root,COG0457@2|Bacteria,COG3391@2|Bacteria,2J5QG@203691|Spirochaetes	203691|Spirochaetes	S	NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL,TPR_11
MMS1_k127_1043138_7	889378.Spiaf_1932	1.22e-50	188.0	COG0457@1|root,COG0457@2|Bacteria,2J6BA@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
MMS1_k127_1043138_4	573413.Spirs_3174	1.069e-83	284.0	COG0496@1|root,COG0496@2|Bacteria,2J7HR@203691|Spirochaetes	203691|Spirochaetes	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
MMS1_k127_1043138_2	573413.Spirs_3175	5.36e-108	362.0	COG0153@1|root,COG0153@2|Bacteria,2J58W@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GHMP kinase family	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
MMS1_k127_1043138_12	573413.Spirs_3178	1.159e-30	122.0	COG0254@1|root,COG0254@2|Bacteria,2J93Z@203691|Spirochaetes	203691|Spirochaetes	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
MMS1_k127_1043138_0	1123274.KB899431_gene3287	5.601e-223	706.0	COG1158@1|root,COG1158@2|Bacteria,2J5BW@203691|Spirochaetes	203691|Spirochaetes	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
MMS1_k127_1043138_9	930169.B5T_03102	4.041e-38	148.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1XJYU@135619|Oceanospirillales	135619|Oceanospirillales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
MMS1_k127_1043138_11	889378.Spiaf_1939	9.041e-33	131.0	COG1664@1|root,COG1664@2|Bacteria,2J85N@203691|Spirochaetes	203691|Spirochaetes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS1_k127_1043138_13	1480694.DC28_03070	2.872e-23	102.0	COG2114@1|root,COG2114@2|Bacteria,2JAV7@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1043138_5	1307761.L21SP2_1376	1.739e-82	280.0	COG0745@1|root,COG0745@2|Bacteria,2J7JA@203691|Spirochaetes	203691|Spirochaetes	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS1_k127_1043138_8	1123274.KB899431_gene3281	2.337e-40	151.0	COG0776@1|root,COG0776@2|Bacteria,2J7PW@203691|Spirochaetes	203691|Spirochaetes	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K04764,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS1_k127_1043138_17	1307761.L21SP2_1373	1.333e-16	83.0	COG0268@1|root,COG0268@2|Bacteria	2|Bacteria	J	rRNA binding	rpsT	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
MMS1_k127_1043138_16	744872.Spica_1612	2.005e-20	91.0	2ERI0@1|root,33J3G@2|Bacteria,2J8XU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1043138_3	573413.Spirs_3187	3.315e-98	329.0	COG1774@1|root,COG1774@2|Bacteria,2J5RE@203691|Spirochaetes	203691|Spirochaetes	S	PFAM PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
MMS1_k127_1043138_14	1123274.KB899431_gene3278	1.385e-22	103.0	COG1728@1|root,COG1728@2|Bacteria,2J8M6@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF327)	-	-	-	ko:K09770	-	-	-	-	ko00000	-	-	-	DUF327
MMS1_k127_1043138_10	1123274.KB899431_gene3277	5.027e-38	147.0	COG1664@1|root,COG1664@2|Bacteria,2J82J@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS1_k127_1043138_6	754027.HMPREF9554_02837	9.878e-80	278.0	COG0739@1|root,COG0739@2|Bacteria,2J5SN@203691|Spirochaetes	203691|Spirochaetes	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS1_k127_1044623_1	1536773.R70331_07490	1.402e-27	120.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V4UB@1239|Firmicutes,4HDDC@91061|Bacilli,274DF@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1044623_0	397287.C807_00562	1.815e-151	494.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,27IA2@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1044623_2	1196095.GAPWK_1905	3.143e-23	111.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1RNTS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015591,GO:0015749,GO:0015750,GO:0015752,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034219,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	iAF1260.b3750,iAPECO1_1312.APECO1_2713,iB21_1397.B21_03581,iBWG_1329.BWG_3441,iE2348C_1286.E2348C_4060,iEC042_1314.EC042_4137,iEC55989_1330.EC55989_4225,iECABU_c1320.ECABU_c42350,iECBD_1354.ECBD_4280,iECB_1328.ECB_03636,iECDH10B_1368.ECDH10B_3938,iECDH1ME8569_1439.ECDH1ME8569_3638,iECED1_1282.ECED1_4440,iECH74115_1262.ECH74115_5186,iECIAI1_1343.ECIAI1_3934,iECNA114_1301.ECNA114_3899,iECO103_1326.ECO103_4407,iECO111_1330.ECO111_4584,iECO26_1355.ECO26_4828,iECOK1_1307.ECOK1_4199,iECS88_1305.ECS88_4172,iECSE_1348.ECSE_4040,iECSF_1327.ECSF_3598,iECSP_1301.ECSP_4800,iECUMN_1333.ECUMN_4280,iECs_1301.ECs4692,iEcDH1_1363.EcDH1_4217,iEcE24377_1341.EcE24377A_4266,iEcHS_1320.EcHS_A3966,iEcSMS35_1347.EcSMS35_4118,iEcolC_1368.EcolC_4244,iJO1366.b3750,iJR904.b3750,iLF82_1304.LF82_1817,iNRG857_1313.NRG857_18675,iUMN146_1321.UM146_18940,iUMNK88_1353.UMNK88_4562,iUTI89_1310.UTI89_C4305,iY75_1357.Y75_RS18320,ic_1306.c4678	BPD_transp_2
MMS1_k127_1048547_2	1499967.BAYZ01000181_gene4497	3.354e-29	122.0	COG0169@1|root,COG0169@2|Bacteria,2NPR3@2323|unclassified Bacteria	2|Bacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS1_k127_1048547_1	720554.Clocl_3226	8.509e-62	221.0	COG0778@1|root,COG0778@2|Bacteria,1V3YJ@1239|Firmicutes,24BKH@186801|Clostridia,3WJMB@541000|Ruminococcaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
MMS1_k127_1048547_0	573413.Spirs_4181	3.725e-138	445.0	COG0656@1|root,COG0656@2|Bacteria,2J5XV@203691|Spirochaetes	203691|Spirochaetes	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_1055088_1	243365.CV_3435	5.48e-39	152.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,2VJ1T@28216|Betaproteobacteria,2KRGF@206351|Neisseriales	206351|Neisseriales	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	-	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
MMS1_k127_1055088_2	1187851.A33M_4061	9.495e-21	96.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2V8YG@28211|Alphaproteobacteria,3FECF@34008|Rhodovulum	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
MMS1_k127_1055088_0	1480694.DC28_08300	7.079e-108	372.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_1057512_2	742733.HMPREF9469_00781	1.127e-156	506.0	COG1653@1|root,COG1653@2|Bacteria,1VTX8@1239|Firmicutes,24ZPV@186801|Clostridia,223EJ@1506553|Lachnoclostridium	2|Bacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
MMS1_k127_1057512_0	573413.Spirs_0807	2.5e-323	1005.0	COG1652@1|root,COG1912@1|root,COG2365@1|root,COG1652@2|Bacteria,COG1912@2|Bacteria,COG2365@2|Bacteria,2J5VK@203691|Spirochaetes	203691|Spirochaetes	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SAM_adeno_trans,Y_phosphatase3
MMS1_k127_1057512_1	521460.Athe_0165	8.406e-194	619.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,42HNP@68295|Thermoanaerobacterales	186801|Clostridia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1,3.2.1.10	ko:K01176,ko:K01182	ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973	-	R00801,R01718,R01791,R02108,R02112,R06199,R11262	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
MMS1_k127_1057512_3	1121004.ATVC01000014_gene2031	4.068e-48	177.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria	1224|Proteobacteria	T	Adenylate cyclase	cyaG2	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,NTP_transf_9
MMS1_k127_1057545_0	1304284.L21TH_1288	5.071e-91	309.0	COG0524@1|root,COG1522@1|root,COG0524@2|Bacteria,COG1522@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,36F1Z@31979|Clostridiaceae	186801|Clostridia	G	hmm pf00294	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
MMS1_k127_1057545_1	906968.Trebr_2579	4.857e-08	64.0	2ANEW@1|root,31DDI@2|Bacteria,2JAAF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1062565_0	448385.sce1392	2.598e-48	185.0	COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,43837@68525|delta/epsilon subdivisions,2X3D5@28221|Deltaproteobacteria,2YVHN@29|Myxococcales	28221|Deltaproteobacteria	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
MMS1_k127_1062565_1	698758.AXY_05880	6.075e-24	111.0	COG1714@1|root,COG1714@2|Bacteria,1UWM8@1239|Firmicutes,4HBNM@91061|Bacilli	91061|Bacilli	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
MMS1_k127_1062565_2	391625.PPSIR1_29343	4.05e-05	53.0	COG5523@1|root,COG5523@2|Bacteria,1PVR8@1224|Proteobacteria,434AQ@68525|delta/epsilon subdivisions,2WZ03@28221|Deltaproteobacteria,2Z11H@29|Myxococcales	28221|Deltaproteobacteria	J	Uncharacterised protein family (UPF0259)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1064807_0	1307761.L21SP2_0435	4.638e-171	551.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
MMS1_k127_1065202_10	1123274.KB899412_gene1392	7.008e-44	166.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	pdhR	-	-	ko:K05799,ko:K13637	-	-	-	-	ko00000,ko03000	-	-	-	FCD,FadR_C,GntR
MMS1_k127_1065202_4	1123274.KB899411_gene3079	1.234e-184	580.0	COG0057@1|root,COG0057@2|Bacteria,2J6YR@203691|Spirochaetes	203691|Spirochaetes	C	glyceraldehyde-3-phosphate dehydrogenase, type II	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
MMS1_k127_1065202_3	573413.Spirs_0989	1.3e-189	599.0	COG0126@1|root,COG0126@2|Bacteria,2J6Y0@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglycerate kinase	-	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS1_k127_1065202_8	1123274.KB899412_gene1393	9.098e-115	376.0	COG3959@1|root,COG3959@2|Bacteria,2J7TK@203691|Spirochaetes	203691|Spirochaetes	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS1_k127_1065202_9	573413.Spirs_2991	1.276e-113	374.0	COG3958@1|root,COG3958@2|Bacteria,2J64Y@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS1_k127_1065202_5	1123274.KB899411_gene3081	6.684e-151	488.0	COG3875@1|root,COG3875@2|Bacteria,2J6AY@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
MMS1_k127_1065202_2	158190.SpiGrapes_1363	5.907e-212	666.0	COG0281@1|root,COG0281@2|Bacteria,2J5DN@203691|Spirochaetes	203691|Spirochaetes	C	Malic enzyme, NAD binding domain	mdh	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
MMS1_k127_1065202_1	574087.Acear_0203	6.391e-216	703.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TQJM@1239|Firmicutes,24CFC@186801|Clostridia	186801|Clostridia	C	TIGRFAM glycerol-3-phosphate dehydrogenase, anaerobic, C subunit	glpC	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
MMS1_k127_1065202_7	1123274.KB899412_gene1397	2.381e-121	394.0	COG3718@1|root,COG3718@2|Bacteria,2J83A@203691|Spirochaetes	203691|Spirochaetes	G	PFAM KduI IolB family	-	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
MMS1_k127_1065202_0	1116375.VEJY3_08625	9.231e-292	907.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,1RQ39@1236|Gammaproteobacteria,1XT2G@135623|Vibrionales	135623|Vibrionales	E	Belongs to the TPP enzyme family	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS1_k127_1065202_6	1123274.KB899412_gene1399	1.537e-145	466.0	COG1082@1|root,COG1082@2|Bacteria,2J6VN@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Xylose isomerase-like TIM barrel	-	-	4.2.1.44	ko:K03335	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R02782,R05659	RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
MMS1_k127_1066600_1	1278309.KB907101_gene799	4.991e-82	278.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,1RNSF@1236|Gammaproteobacteria,1XIKR@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS1_k127_1066600_0	717231.Flexsi_0168	2.567e-215	676.0	COG0499@1|root,COG0499@2|Bacteria,2GEPA@200930|Deferribacteres	200930|Deferribacteres	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMS1_k127_1066600_2	1121405.dsmv_1385	2.853e-26	120.0	COG5652@1|root,COG5652@2|Bacteria,1R7IX@1224|Proteobacteria	1224|Proteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III,VanZ
MMS1_k127_106673_2	227377.CBU_1458	6.331e-81	278.0	COG1373@1|root,COG1373@2|Bacteria,1NQGE@1224|Proteobacteria,1SS26@1236|Gammaproteobacteria,1JGAX@118969|Legionellales	118969|Legionellales	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4143
MMS1_k127_106673_0	1205680.CAKO01000029_gene5250	2.018e-220	713.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2JPN7@204441|Rhodospirillales	204441|Rhodospirillales	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
MMS1_k127_106673_1	698758.AXY_05220	1.537e-144	471.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,4HEHY@91061|Bacilli	91061|Bacilli	V	Na -driven multidrug efflux pump	mepA	-	-	ko:K18908	-	M00705	-	-	ko00000,ko00002,ko01504,ko02000	2.A.66.1.13	-	-	MatE
MMS1_k127_106673_3	1123511.KB905842_gene1674	1.179e-11	71.0	COG1846@1|root,COG1846@2|Bacteria,1VERP@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_1070639_0	379066.GAU_0235	3.246e-133	436.0	COG0154@1|root,COG0154@2|Bacteria,1ZT8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
MMS1_k127_1070639_2	1123274.KB899416_gene2555	2.852e-91	321.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HAMP,HATPase_c,HisKA,PAS,dCache_3
MMS1_k127_1070639_3	551789.ATVJ01000001_gene1447	1.539e-63	226.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,43WHK@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1070639_1	1237149.C900_00776	5.748e-96	331.0	COG4452@1|root,COG4452@2|Bacteria,4NGKY@976|Bacteroidetes,47NWS@768503|Cytophagia	976|Bacteroidetes	V	Inner membrane protein CreD	creD	-	-	ko:K06143	-	-	-	-	ko00000	-	-	-	CreD
MMS1_k127_1073451_1	744872.Spica_1497	5.542e-21	104.0	COG3118@1|root,COG3118@2|Bacteria,2J76D@203691|Spirochaetes	203691|Spirochaetes	O	belongs to the thioredoxin family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1073451_0	573413.Spirs_2452	0.0	1139.0	COG0178@1|root,COG0178@2|Bacteria,2J5BN@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
MMS1_k127_1078359_5	720554.Clocl_2091	2.636e-07	57.0	2E5V7@1|root,330JA@2|Bacteria,1VFNT@1239|Firmicutes,24RD2@186801|Clostridia,3WM1B@541000|Ruminococcaceae	186801|Clostridia	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
MMS1_k127_1078359_4	1408310.JHUW01000007_gene572	1.574e-10	72.0	28RJ8@1|root,32TGW@2|Bacteria,4P018@976|Bacteroidetes,2G095@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1078359_8	1122939.ATUD01000003_gene3306	1.484e-05	53.0	COG0681@1|root,COG0681@2|Bacteria,2HF4W@201174|Actinobacteria,4CTUY@84995|Rubrobacteria	84995|Rubrobacteria	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
MMS1_k127_1078359_7	749222.Nitsa_1710	1.06e-05	57.0	COG1216@1|root,COG1216@2|Bacteria,1N5RX@1224|Proteobacteria,42SF0@68525|delta/epsilon subdivisions,2YRNI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
MMS1_k127_1078359_1	368408.Tpen_1400	2.156e-51	196.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPS7@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS1_k127_1078359_2	247490.KSU1_C0427	4.455e-49	185.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS1_k127_1078359_0	177439.DP2372	8.949e-105	350.0	COG1041@1|root,COG1041@2|Bacteria	2|Bacteria	L	tRNA (guanine-N2-)-methyltransferase activity	rumA	-	-	-	-	-	-	-	-	-	-	-	UPF0020
MMS1_k127_1078359_3	1192034.CAP_6018	4.697e-24	104.0	COG3644@1|root,COG3644@2|Bacteria,1RK12@1224|Proteobacteria,436NH@68525|delta/epsilon subdivisions,2X1AB@28221|Deltaproteobacteria,2Z1B2@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2239)	-	-	-	ko:K09965	-	-	-	-	ko00000	-	-	-	DUF2239
MMS1_k127_1080771_2	1256908.HMPREF0373_03454	5.125e-41	154.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5,5.1.99.1	ko:K01759,ko:K05606,ko:K08234	ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02530,R02765,R09979	RC00004,RC00740,RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
MMS1_k127_1080771_1	1256908.HMPREF0373_01934	1.019e-44	184.0	COG2340@1|root,COG2340@2|Bacteria,1VSZA@1239|Firmicutes,24Y3F@186801|Clostridia	186801|Clostridia	S	Cysteine-rich secretory protein family	-	-	-	ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	-
MMS1_k127_1080771_0	903818.KI912268_gene2359	5.621e-146	471.0	COG1063@1|root,COG1063@2|Bacteria,3Y3WP@57723|Acidobacteria	57723|Acidobacteria	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA
MMS1_k127_1080771_3	1117108.PAALTS15_20178	4.234e-21	100.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TYUA@1239|Firmicutes,4HDKK@91061|Bacilli,26QYP@186822|Paenibacillaceae	91061|Bacilli	T	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1081556_0	1123274.KB899421_gene1743	9.621e-103	339.0	COG0217@1|root,COG0217@2|Bacteria,2J634@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
MMS1_k127_1081556_2	744872.Spica_1340	4.414e-53	191.0	COG0817@1|root,COG0817@2|Bacteria,2J754@203691|Spirochaetes	203691|Spirochaetes	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
MMS1_k127_1081556_3	1410609.JHVB01000001_gene2294	7.454e-45	169.0	COG0632@1|root,COG0632@2|Bacteria,2J6FC@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
MMS1_k127_1081556_1	1539298.JO41_06010	1.027e-61	215.0	COG2255@1|root,COG2255@2|Bacteria,2J5IU@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
MMS1_k127_1082187_0	889378.Spiaf_1472	7.334e-176	572.0	COG3605@1|root,COG3605@2|Bacteria,2JBCF@203691|Spirochaetes	203691|Spirochaetes	T	GAF domain	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
MMS1_k127_1082187_1	545694.TREPR_0178	2.549e-51	186.0	COG0714@1|root,COG0714@2|Bacteria,2J5SG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_1082637_2	1163408.UU9_14035	4.119e-07	54.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,1X3GG@135614|Xanthomonadales	135614|Xanthomonadales	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
MMS1_k127_1082637_0	744872.Spica_1005	3.027e-30	128.0	2C73B@1|root,330Z7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS1_k127_1082637_1	754027.HMPREF9554_01106	1.067e-08	64.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1086819_2	511437.Lbuc_1850	1.167e-19	92.0	COG2207@1|root,COG2207@2|Bacteria,1V28B@1239|Firmicutes,4HDPB@91061|Bacilli,3F6WX@33958|Lactobacillaceae	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
MMS1_k127_1086819_1	573413.Spirs_0081	7.126e-40	154.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	yisX	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
MMS1_k127_1086819_0	1565129.JSFF01000004_gene3221	6.402e-86	299.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2QA5T@267890|Shewanellaceae	1236|Gammaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
MMS1_k127_1091993_0	1144319.PMI16_04926	2.251e-34	135.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VRBV@28216|Betaproteobacteria,478XB@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K14979	ko02020,map02020	M00663	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
MMS1_k127_1091993_1	589865.DaAHT2_2549	8.244e-09	66.0	COG5581@1|root,COG5581@2|Bacteria	2|Bacteria	M	regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed	pilZ	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
MMS1_k127_1095514_2	177439.DP0462	3.166e-09	59.0	COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,42MQF@68525|delta/epsilon subdivisions,2WIUE@28221|Deltaproteobacteria,2MJ68@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
MMS1_k127_1095514_0	158190.SpiGrapes_2655	1.382e-230	726.0	COG0488@1|root,COG0488@2|Bacteria,2JA3A@203691|Spirochaetes	203691|Spirochaetes	S	ATPase component of ABC transporters with duplicated ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
MMS1_k127_1095514_1	926569.ANT_28670	2.78e-122	405.0	COG1252@1|root,COG1252@2|Bacteria,2G5SS@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS1_k127_1095514_3	1123371.ATXH01000001_gene1273	5.795e-07	59.0	COG2204@1|root,COG2204@2|Bacteria,2GIFH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Magnesium chelatase, subunit ChlI	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_1096490_0	935948.KE386494_gene118	1.362e-62	224.0	COG2972@1|root,COG2972@2|Bacteria,1TR81@1239|Firmicutes,24CKZ@186801|Clostridia,42FVI@68295|Thermoanaerobacterales	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
MMS1_k127_1096490_1	935948.KE386494_gene117	2.767e-31	137.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UNEQ@1239|Firmicutes,24E34@186801|Clostridia,42HWE@68295|Thermoanaerobacterales	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_1096787_0	1321815.HMPREF9193_00590	1.457e-25	111.0	COG0142@1|root,COG0142@2|Bacteria,2J673@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.30,2.5.1.90	ko:K00805,ko:K02523,ko:K13787,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365,M00366	R01658,R02003,R02061,R09247,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS1_k127_1097106_1	931276.Cspa_c25260	1.186e-67	239.0	COG2206@1|root,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,36USB@31979|Clostridiaceae	186801|Clostridia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HD,HD_5,dCache_1
MMS1_k127_1097106_0	381764.Fnod_0551	5.517e-80	282.0	COG0477@1|root,COG2814@2|Bacteria,2GDPA@200918|Thermotogae	200918|Thermotogae	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1102785_1	459495.SPLC1_S051590	1.893e-43	174.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1G3VK@1117|Cyanobacteria,1HA0X@1150|Oscillatoriales	1117|Cyanobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Guanylate_cyc
MMS1_k127_1102785_2	1038867.AXAY01000023_gene4587	5.627e-19	95.0	COG0596@1|root,COG0596@2|Bacteria,1R3U1@1224|Proteobacteria,2TVFV@28211|Alphaproteobacteria,3JQPU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
MMS1_k127_1102785_0	1307761.L21SP2_0412	9.847e-125	411.0	COG0454@1|root,COG0456@2|Bacteria,2J7A2@203691|Spirochaetes	203691|Spirochaetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_110586_0	243231.GSU1290	3.073e-145	470.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,43S4S@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Signal transducing histidine kinase homodimeric	cheA34H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
MMS1_k127_110586_1	573413.Spirs_1823	1.85e-71	246.0	COG2201@1|root,COG2201@2|Bacteria,2J6I0@203691|Spirochaetes	203691|Spirochaetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB-2	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1108324_2	1123511.KB905874_gene17	1.116e-85	290.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,4H5HG@909932|Negativicutes	909932|Negativicutes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_1108324_0	357808.RoseRS_2134	0.0	1306.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GAC0@200795|Chloroflexi,376BQ@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
MMS1_k127_1108324_1	382245.ASA_2318	1.011e-136	451.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RUEK@1236|Gammaproteobacteria,1Y6FA@135624|Aeromonadales	135624|Aeromonadales	C	BFD-like [2Fe-2S] binding domain	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
MMS1_k127_1108324_4	1121459.AQXE01000002_gene1363	5.638e-42	172.0	COG3075@1|root,COG3075@2|Bacteria,1MU3K@1224|Proteobacteria,42Q09@68525|delta/epsilon subdivisions,2WKE0@28221|Deltaproteobacteria,2M7WY@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Glycerol-3-phosphate dehydrogenase, anaerobic, B subunit	-	-	1.1.5.3	ko:K00112	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
MMS1_k127_1108324_3	1211814.CAPG01000003_gene123	5.621e-51	193.0	COG0247@1|root,COG0247@2|Bacteria,1TQJM@1239|Firmicutes,4HV6E@91061|Bacilli,1ZF5N@1386|Bacillus	91061|Bacilli	C	4Fe-4S dicluster domain	-	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
MMS1_k127_1109223_3	931276.Cspa_c35110	1.569e-43	161.0	COG3123@1|root,COG3123@2|Bacteria,1VBF3@1239|Firmicutes,24JI0@186801|Clostridia,36K51@31979|Clostridiaceae	186801|Clostridia	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
MMS1_k127_1109223_0	1499967.BAYZ01000076_gene754	7.268e-114	378.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
MMS1_k127_1109223_1	1120971.AUCA01000009_gene2000	2.034e-76	265.0	COG0412@1|root,COG0412@2|Bacteria,1UZRU@1239|Firmicutes,4HEHA@91061|Bacilli,2785N@186823|Alicyclobacillaceae	91061|Bacilli	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS1_k127_1109223_2	1034943.BN1094_01632	4.269e-55	204.0	COG2324@1|root,COG2324@2|Bacteria,1RA24@1224|Proteobacteria,1SXPG@1236|Gammaproteobacteria,1JCME@118969|Legionellales	118969|Legionellales	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
MMS1_k127_1109223_4	1250232.JQNJ01000001_gene2262	2.144e-39	151.0	arCOG06733@1|root,313GU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1109463_2	1123519.PSJM300_13790	7.889e-07	50.0	arCOG05276@1|root,3195F@2|Bacteria,1RHZA@1224|Proteobacteria,1S86B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1109463_0	1122919.KB905551_gene1793	3.335e-100	353.0	2DB7A@1|root,2Z7KK@2|Bacteria,1TZSZ@1239|Firmicutes,4HFM6@91061|Bacilli,27775@186822|Paenibacillaceae	91061|Bacilli	S	Glycosyl hydrolase family 115	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_115
MMS1_k127_1109463_1	760011.Spico_0869	3.439e-15	80.0	COG1653@1|root,COG1653@2|Bacteria,2JA1G@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_1110507_5	13035.Dacsa_1483	4.234e-17	82.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
MMS1_k127_1110507_0	1307761.L21SP2_2602	1.586e-303	944.0	COG3808@1|root,COG3808@2|Bacteria,2J6RD@203691|Spirochaetes	203691|Spirochaetes	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMS1_k127_1110507_4	1307761.L21SP2_2601	6.743e-94	314.0	28JYD@1|root,2Z9NN@2|Bacteria	1307761.L21SP2_2601|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1110507_3	86416.Clopa_0443	7.48e-111	373.0	COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,25B1W@186801|Clostridia,36W7P@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
MMS1_k127_1110507_1	1122599.AUGR01000022_gene1630	1.373e-228	736.0	COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,1XQ5I@135619|Oceanospirillales	135619|Oceanospirillales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMS1_k127_1110507_2	1396418.BATQ01000054_gene8	1.08e-119	403.0	2DBRE@1|root,2ZAK7@2|Bacteria,46TZ4@74201|Verrucomicrobia,2ITNY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1110666_0	517417.Cpar_1626	1.087e-112	371.0	COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1FDRX@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM nitrogenase cofactor biosynthesis protein NifB	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Nitro_FeMo-Co,Radical_SAM
MMS1_k127_1110666_1	1121403.AUCV01000044_gene56	4.574e-50	182.0	COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,42MPD@68525|delta/epsilon subdivisions,2WJ05@28221|Deltaproteobacteria,2MJ48@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
MMS1_k127_1119004_0	889378.Spiaf_2854	5.473e-159	508.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
MMS1_k127_1119004_2	889378.Spiaf_2822	8.769e-111	366.0	COG0330@1|root,COG0330@2|Bacteria,2J5YQ@203691|Spirochaetes	203691|Spirochaetes	O	SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
MMS1_k127_1119004_1	889378.Spiaf_2821	5.324e-114	375.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
MMS1_k127_1119004_4	573413.Spirs_0082	9.321e-20	95.0	COG1585@1|root,COG1585@2|Bacteria,2J89B@203691|Spirochaetes	203691|Spirochaetes	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
MMS1_k127_1119004_3	869209.Tresu_0357	1.141e-29	121.0	COG1739@1|root,COG1739@2|Bacteria,2J7AS@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0029, Impact, N-terminal	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF1949,UPF0029
MMS1_k127_1120499_1	350688.Clos_2456	1.188e-67	237.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36F5I@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, LacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
MMS1_k127_1120499_0	1449126.JQKL01000060_gene1860	8.69e-133	434.0	COG0167@1|root,COG0167@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,26BIN@186813|unclassified Clostridiales	186801|Clostridia	F	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4
MMS1_k127_1120499_2	1267003.KB911418_gene900	9.45e-09	62.0	2DC1F@1|root,2ZCE5@2|Bacteria,1VGS5@1239|Firmicutes,4IFRG@91061|Bacilli,3F6VB@33958|Lactobacillaceae	91061|Bacilli	S	Protein of unknown function (DUF2877)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2877
MMS1_k127_1126203_0	1128421.JAGA01000002_gene1484	2.392e-160	517.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1126203_2	1224318.DT73_15980	7.304e-38	151.0	COG3752@1|root,COG3752@2|Bacteria,1MYN3@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
MMS1_k127_1126203_1	1250278.JQNQ01000001_gene1290	5.325e-139	448.0	COG0667@1|root,COG0667@2|Bacteria,4NHA1@976|Bacteroidetes,1HZQF@117743|Flavobacteriia	976|Bacteroidetes	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_1127412_0	1123274.KB899408_gene3912	2.722e-76	268.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
MMS1_k127_1132434_1	888727.HMPREF9092_1421	3.927e-62	219.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WCDT@538999|Clostridiales incertae sedis	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.30,3.6.3.31	ko:K02010,ko:K11072	ko02010,map02010	M00190,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11.1	-	-	ABC_tran,TOBE_2
MMS1_k127_1132434_0	866546.EPY53251	1.384e-94	317.0	COG0106@1|root,KOG3055@2759|Eukaryota,39RKQ@33154|Opisthokonta,3NVJU@4751|Fungi,3QM1R@4890|Ascomycota	4751|Fungi	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	HIS6	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMS1_k127_1132434_2	1410613.JNKF01000012_gene1364	1.741e-17	93.0	COG1409@1|root,COG1409@2|Bacteria,4P92R@976|Bacteroidetes,2FZZH@200643|Bacteroidia	976|Bacteroidetes	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
MMS1_k127_1134968_1	536232.CLM_0771	1.011e-44	168.0	COG0664@1|root,COG0664@2|Bacteria,1V5MZ@1239|Firmicutes,24AQS@186801|Clostridia,36G37@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, Crp Fnr family(	-	-	-	ko:K21562	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_1134968_3	1191299.AJYX01000102_gene2445	6.758e-20	93.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1SAJ2@1236|Gammaproteobacteria,1XXUY@135623|Vibrionales	135623|Vibrionales	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
MMS1_k127_1134968_2	158189.SpiBuddy_1686	1.104e-26	118.0	COG2461@1|root,COG2461@2|Bacteria,2JA8V@203691|Spirochaetes	203691|Spirochaetes	S	PAS domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	PAS_10
MMS1_k127_1134968_0	744872.Spica_0995	1.054e-126	415.0	COG2461@1|root,COG2461@2|Bacteria,2J7GM@203691|Spirochaetes	203691|Spirochaetes	S	PAS domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
MMS1_k127_1136112_1	318586.Pden_2561	4.202e-85	293.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,2PWUQ@265|Paracoccus	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1136112_2	484770.UFO1_0686	1.797e-55	198.0	COG0655@1|root,COG0655@2|Bacteria,1VCYD@1239|Firmicutes	1239|Firmicutes	S	Nadph-dependent fmn reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_1136112_0	1480694.DC28_13205	2.156e-92	311.0	28I7A@1|root,2Z8A6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1136112_3	1196322.A370_03907	9.454e-07	51.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,24K4J@186801|Clostridia,36JND@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
MMS1_k127_1136516_0	665571.STHERM_c08280	8.214e-118	390.0	COG1070@1|root,COG1070@2|Bacteria,2J5PS@203691|Spirochaetes	203691|Spirochaetes	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
MMS1_k127_1143560_0	744872.Spica_2023	3.848e-142	473.0	COG0841@1|root,COG0841@2|Bacteria,2J6SF@203691|Spirochaetes	203691|Spirochaetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_115657_0	521045.Kole_1073	3.377e-158	507.0	COG1653@1|root,COG1653@2|Bacteria,2GCPM@200918|Thermotogae	200918|Thermotogae	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_115657_1	316274.Haur_1151	4.809e-100	336.0	COG1175@1|root,COG1175@2|Bacteria,2G8BY@200795|Chloroflexi,3773P@32061|Chloroflexia	32061|Chloroflexia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_115657_2	365044.Pnap_0230	2.349e-19	91.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VICF@28216|Betaproteobacteria,4AJ5Y@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K17246	ko02010,map02010	M00207,M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.40	-	-	BPD_transp_1
MMS1_k127_1159899_2	573413.Spirs_0898	2.665e-66	244.0	COG1538@1|root,COG1538@2|Bacteria,2J6ZZ@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
MMS1_k127_1159899_1	573413.Spirs_0037	8.282e-74	259.0	COG0845@1|root,COG0845@2|Bacteria,2J6DV@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mtrC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
MMS1_k127_1159899_0	573413.Spirs_0038	0.0	1194.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	acrB	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
MMS1_k127_1159899_3	665571.STHERM_c21680	2.055e-29	119.0	2EAU9@1|root,334VX@2|Bacteria,2J8CD@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1163566_0	665571.STHERM_c09400	5.282e-81	274.0	COG0811@1|root,COG0811@2|Bacteria,2J700@203691|Spirochaetes	203691|Spirochaetes	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
MMS1_k127_1163566_3	665571.STHERM_c09390	1.554e-28	120.0	COG0848@1|root,COG0848@2|Bacteria,2J82R@203691|Spirochaetes	203691|Spirochaetes	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
MMS1_k127_1163566_1	665571.STHERM_c18720	7.775e-59	211.0	COG0546@1|root,COG0546@2|Bacteria,2J7JD@203691|Spirochaetes	203691|Spirochaetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS1_k127_1163566_4	744872.Spica_2110	1.109e-14	77.0	COG1196@1|root,COG1196@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
MMS1_k127_1167442_1	1122927.KB895414_gene5403	4.415e-119	411.0	COG2207@1|root,COG2207@2|Bacteria,1UZWN@1239|Firmicutes,4HTAK@91061|Bacilli,26SKH@186822|Paenibacillaceae	91061|Bacilli	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,dCache_1
MMS1_k127_1167442_0	1395587.P364_0100955	3.537e-157	506.0	COG1653@1|root,COG1653@2|Bacteria,1TR5P@1239|Firmicutes,4HAFJ@91061|Bacilli,26S5W@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1
MMS1_k127_1168366_6	403833.Pmob_1605	3.756e-50	190.0	COG0679@1|root,COG0679@2|Bacteria	2|Bacteria	S	auxin-activated signaling pathway	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
MMS1_k127_1168366_5	545695.TREAZ_3106	8.861e-70	247.0	COG0524@1|root,COG0524@2|Bacteria,2J6UQ@203691|Spirochaetes	203691|Spirochaetes	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS1_k127_1168366_2	760011.Spico_1644	7.745e-134	436.0	COG1879@1|root,COG1879@2|Bacteria,2J800@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1168366_1	158190.SpiGrapes_2639	6.257e-134	440.0	COG1172@1|root,COG1172@2|Bacteria,2J7N5@203691|Spirochaetes	203691|Spirochaetes	G	COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_1168366_0	158189.SpiBuddy_2502	9.471e-224	704.0	COG1129@1|root,COG1129@2|Bacteria,2J64A@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1168366_4	744872.Spica_2148	2.297e-72	255.0	COG1879@1|root,COG1879@2|Bacteria,2JAXM@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding protein-like domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1168366_3	744872.Spica_2147	4.881e-117	391.0	COG2972@1|root,COG2972@2|Bacteria,2J6ZX@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
MMS1_k127_1168366_8	357809.Cphy_2008	3.034e-10	68.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,21XTZ@1506553|Lachnoclostridium	186801|Clostridia	T	signal transduction protein with a C-terminal ATPase domain	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
MMS1_k127_1168366_7	1449063.JMLS01000004_gene2753	1.193e-31	134.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,26T2X@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1171134_1	1191523.MROS_2214	3.378e-24	112.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,TonB_dep_Rec
MMS1_k127_1171134_0	926559.JoomaDRAFT_0353	2.47e-40	162.0	COG3712@1|root,COG3712@2|Bacteria,4NRYT@976|Bacteroidetes,1I3PA@117743|Flavobacteriia	976|Bacteroidetes	PT	Fe2 -dicitrate sensor, membrane component	-	-	-	-	-	-	-	-	-	-	-	-	DUF4974,FecR
MMS1_k127_1171134_2	1121904.ARBP01000014_gene106	1.802e-07	53.0	COG1595@1|root,COG1595@2|Bacteria,4NRYN@976|Bacteroidetes,47XMB@768503|Cytophagia	976|Bacteroidetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
MMS1_k127_1172258_2	1122609.AUGT01000006_gene1497	2.724e-08	61.0	COG5012@1|root,COG5012@2|Bacteria,2I2EI@201174|Actinobacteria	201174|Actinobacteria	S	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
MMS1_k127_1172258_3	582744.Msip34_1185	4.554e-05	55.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,2VI8Z@28216|Betaproteobacteria,2KKYQ@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
MMS1_k127_1172258_0	1307761.L21SP2_2678	0.0	1071.0	COG0841@1|root,COG0841@2|Bacteria,2J9MF@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_1172258_1	666685.R2APBS1_0144	8.854e-76	272.0	COG0477@1|root,COG2814@2|Bacteria,1PJVW@1224|Proteobacteria,1RTG0@1236|Gammaproteobacteria,1X80K@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMS1_k127_1174728_1	1307761.L21SP2_2615	5.034e-49	185.0	COG1609@1|root,COG1609@2|Bacteria,2J7IG@203691|Spirochaetes	203691|Spirochaetes	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1174728_3	1173028.ANKO01000018_gene1202	1.171e-17	97.0	COG2931@1|root,COG5276@1|root,COG2931@2|Bacteria,COG5276@2|Bacteria,1G3QU@1117|Cyanobacteria,1HAPS@1150|Oscillatoriales	1117|Cyanobacteria	Q	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PPC,Peptidase_C11
MMS1_k127_1174728_2	401526.TcarDRAFT_0900	2.164e-18	92.0	COG0778@1|root,COG0778@2|Bacteria,1V4ZI@1239|Firmicutes,4H4BY@909932|Negativicutes	909932|Negativicutes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_1174728_0	1121904.ARBP01000016_gene5188	4.229e-51	189.0	COG0566@1|root,COG0566@2|Bacteria,4NFH3@976|Bacteroidetes,47QCV@768503|Cytophagia	976|Bacteroidetes	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
MMS1_k127_1175638_1	1123274.KB899410_gene3513	5.829e-30	121.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,HTH_34,MarR,MarR_2
MMS1_k127_1175638_0	1480694.DC28_13270	3.74e-139	476.0	COG4258@1|root,COG4258@2|Bacteria	2|Bacteria	I	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_1175638_2	1121904.ARBP01000002_gene6770	3.25e-14	83.0	COG2834@1|root,COG2834@2|Bacteria,4NIT5@976|Bacteroidetes	976|Bacteroidetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_1180853_0	744872.Spica_0822	4.986e-208	651.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
MMS1_k127_1180853_2	744872.Spica_1870	1.231e-36	143.0	COG4273@1|root,COG4273@2|Bacteria	2|Bacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
MMS1_k127_1180853_3	1123274.KB899427_gene3312	2.249e-21	95.0	COG0526@1|root,COG0526@2|Bacteria,2J91P@203691|Spirochaetes	203691|Spirochaetes	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
MMS1_k127_1180853_1	573413.Spirs_0840	7.479e-87	294.0	COG1653@1|root,COG1653@2|Bacteria,2J7XP@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
MMS1_k127_1185352_0	742723.HMPREF9477_00082	1.855e-210	667.0	COG0079@1|root,COG1213@1|root,COG0079@2|Bacteria,COG1213@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,27JCI@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,NTP_transf_3
MMS1_k127_1185352_1	1125699.HMPREF9194_00995	2.64e-83	310.0	COG0706@1|root,COG3119@1|root,COG0706@2|Bacteria,COG3119@2|Bacteria,2J5BD@203691|Spirochaetes	203691|Spirochaetes	PU	Membrane protein insertase, YidC Oxa1 family	-	-	-	-	-	-	-	-	-	-	-	-	60KD_IMP
MMS1_k127_1185352_2	1124982.MSI_24750	8.998e-82	286.0	COG1887@1|root,COG1887@2|Bacteria,2J5FC@203691|Spirochaetes	203691|Spirochaetes	M	CDP-glycerol poly(glycerophosphate) glycerophosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyphos_transf
MMS1_k127_118551_0	1123274.KB899425_gene2744	1.206e-97	330.0	COG2342@1|root,COG2342@2|Bacteria,2J77P@203691|Spirochaetes	203691|Spirochaetes	G	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
MMS1_k127_118551_1	649349.Lbys_2113	9.896e-39	150.0	COG3040@1|root,COG3040@2|Bacteria,4NNFA@976|Bacteroidetes,47QWX@768503|Cytophagia	976|Bacteroidetes	M	Lipocalin / cytosolic fatty-acid binding protein family	blc	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
MMS1_k127_1186241_0	889378.Spiaf_0164	3.748e-155	494.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1186241_1	1449126.JQKL01000057_gene2258	8.074e-43	160.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2692N@186813|unclassified Clostridiales	186801|Clostridia	S	Thioesterase superfamily	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS1_k127_1186241_3	392500.Swoo_2079	1.326e-18	96.0	COG0834@1|root,COG0834@2|Bacteria,1MYFU@1224|Proteobacteria,1SC6B@1236|Gammaproteobacteria,2QBSU@267890|Shewanellaceae	1236|Gammaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_1186241_2	1123274.KB899409_gene566	1.54e-32	130.0	COG1120@1|root,COG1120@2|Bacteria	2|Bacteria	HP	ATPase activity	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
MMS1_k127_1191157_1	573413.Spirs_1389	9.251e-25	109.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS1_k127_1191157_0	573413.Spirs_1386	1.18e-234	747.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,2J6YZ@203691|Spirochaetes	203691|Spirochaetes	C	Selenate reductase YgfK	gltD	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
MMS1_k127_1192124_2	1183377.Py04_1236	1.228e-82	286.0	COG3839@1|root,arCOG00177@2157|Archaea,2XTU1@28890|Euryarchaeota,24302@183968|Thermococci	183968|Thermococci	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02062	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	ABC_tran
MMS1_k127_1192124_0	158190.SpiGrapes_3053	7.934e-125	419.0	COG1178@1|root,COG1178@2|Bacteria,2J5F7@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter (Permease)	-	-	-	ko:K02063	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	BPD_transp_1
MMS1_k127_1192124_1	1343739.PAP_00880	7.933e-96	329.0	COG4143@1|root,arCOG00226@2157|Archaea,2XT44@28890|Euryarchaeota,24311@183968|Thermococci	183968|Thermococci	H	ABC-type thiamine transport system, periplasmic component	-	-	-	ko:K02064	ko02010,map02010	M00191	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.19	-	-	SBP_bac_6
MMS1_k127_1192124_3	744872.Spica_0661	7.636e-18	90.0	2ANXJ@1|root,31DYA@2|Bacteria,2JB64@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1192124_5	1577887.JSYG01000019_gene1754	1.506e-05	49.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,2JBSR@204037|Dickeya	1236|Gammaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
MMS1_k127_1192910_0	573413.Spirs_3914	1.241e-40	154.0	COG1762@1|root,COG1762@2|Bacteria,2J7FM@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
MMS1_k127_1192910_1	1499967.BAYZ01000028_gene1340	6.275e-28	117.0	COG3339@1|root,COG3339@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
MMS1_k127_1192910_2	526222.Desal_3126	6.561e-18	85.0	COG0642@1|root,COG2205@2|Bacteria,1QDTH@1224|Proteobacteria,435M2@68525|delta/epsilon subdivisions,2WZZN@28221|Deltaproteobacteria,2M973@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
MMS1_k127_1196867_0	439235.Dalk_4497	4.832e-52	195.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,42U8Q@68525|delta/epsilon subdivisions,2X5AX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS1_k127_1199244_0	931276.Cspa_c21640	1.663e-114	383.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_1199244_1	889378.Spiaf_0775	7.978e-112	377.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
MMS1_k127_1199244_2	1121447.JONL01000008_gene3495	1.056e-55	204.0	COG4623@1|root,COG4623@2|Bacteria,1QUFW@1224|Proteobacteria	1224|Proteobacteria	M	carbon-oxygen lyase activity, acting on polysaccharides	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1199244_3	1291050.JAGE01000002_gene3544	1.399e-30	127.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,1UJG0@1239|Firmicutes,25G8Z@186801|Clostridia	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
MMS1_k127_120337_1	694431.DESACE_06365	8.58e-06	54.0	COG0457@1|root,COG0457@2|Bacteria	694431.DESACE_06365|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_120337_0	315730.BcerKBAB4_2760	6.471e-12	72.0	2BTC8@1|root,32NI0@2|Bacteria,1V5S5@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_120337_2	397288.C806_01908	0.0009538	45.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,27JB0@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Alpha amylase, N-terminal ig-like domain	tvaI	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,Alpha-amylase_N
MMS1_k127_120428_5	748727.CLJU_c01440	1.032e-09	64.0	COG2768@1|root,COG2768@2|Bacteria,1VET2@1239|Firmicutes,24QUH@186801|Clostridia,36MIM@31979|Clostridiaceae	186801|Clostridia	C	Ferredoxin	fdxA	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_120428_3	1429916.X566_03935	1.617e-67	241.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VF5U@28211|Alphaproteobacteria,3JXA1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS1_k127_120428_2	266264.Rmet_4576	1.41e-83	287.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2W114@28216|Betaproteobacteria,1KFFY@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS1_k127_120428_0	1128421.JAGA01000002_gene834	1.707e-122	404.0	COG4608@1|root,COG4608@2|Bacteria,2NP9Y@2323|unclassified Bacteria	2|Bacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS1_k127_120428_1	1469245.JFBG01000027_gene1472	1.016e-103	347.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,1SMBI@1236|Gammaproteobacteria,1X2WV@135613|Chromatiales	1236|Gammaproteobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	3.6.3.24	ko:K02031,ko:K15583,ko:K15587	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00440	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS1_k127_120428_4	1297865.APJD01000009_gene2851	1.282e-27	126.0	COG0747@1|root,COG0747@2|Bacteria,1PFW6@1224|Proteobacteria,2U1GT@28211|Alphaproteobacteria,3JUHW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Peptide ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS1_k127_1205270_2	1304866.K413DRAFT_4287	3.482e-35	136.0	COG0221@1|root,COG0221@2|Bacteria,1V8EF@1239|Firmicutes,24JN0@186801|Clostridia,36JWH@31979|Clostridiaceae	186801|Clostridia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	-
MMS1_k127_1205270_5	999415.HMPREF9943_00837	4.097e-09	66.0	2A35S@1|root,2ZBW6@2|Bacteria,1V1KJ@1239|Firmicutes,3VRN7@526524|Erysipelotrichia	526524|Erysipelotrichia	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
MMS1_k127_1205270_1	1168034.FH5T_16440	5.144e-41	158.0	COG1390@1|root,COG1390@2|Bacteria,4NTEY@976|Bacteroidetes,2G2KK@200643|Bacteroidia	976|Bacteroidetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_B,vATP-synt_E
MMS1_k127_1205270_3	1313304.CALK_1287	9.599e-27	120.0	COG1527@1|root,COG1527@2|Bacteria	2|Bacteria	C	subunit (C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	DUF2764,vATP-synt_AC39
MMS1_k127_1205270_0	1235803.C825_04854	7.339e-271	844.0	COG1155@1|root,COG1155@2|Bacteria,4NIB6@976|Bacteroidetes,2FMQ6@200643|Bacteroidia,22WQG@171551|Porphyromonadaceae	976|Bacteroidetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS1_k127_1205270_4	1313304.CALK_1285	3.998e-09	60.0	COG1156@1|root,COG1156@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_1205752_1	1385511.N783_14210	8.741e-06	49.0	COG1670@1|root,COG1670@2|Bacteria,1V485@1239|Firmicutes,4IK0P@91061|Bacilli,2YBJ0@289201|Pontibacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_1205752_0	866895.HBHAL_2624	1.022e-09	61.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
MMS1_k127_1206257_0	1457250.BBMO01000001_gene1581	2.414e-05	55.0	COG3291@1|root,arCOG02526@1|root,arCOG03499@1|root,arCOG02508@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,arCOG03499@2157|Archaea,2XUY6@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,PKD,Pilin_N,SdrD_B
MMS1_k127_1210377_1	1480694.DC28_05890	2.935e-80	279.0	COG0534@1|root,COG0534@2|Bacteria,2J7HX@203691|Spirochaetes	203691|Spirochaetes	V	PFAM multi antimicrobial extrusion protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_1210377_2	1274374.CBLK010000020_gene2846	2.588e-35	145.0	COG1917@1|root,COG2169@1|root,COG1917@2|Bacteria,COG2169@2|Bacteria,1V44Y@1239|Firmicutes,4HN01@91061|Bacilli,26TE2@186822|Paenibacillaceae	91061|Bacilli	F	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
MMS1_k127_1210377_0	1122194.AUHU01000004_gene1230	1.818e-122	400.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,1RMIK@1236|Gammaproteobacteria,468NA@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1210523_0	622312.ROSEINA2194_02447	3.598e-35	136.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21,Fer4_6,Fer4_7
MMS1_k127_1210523_2	255470.cbdbA1081	5.759e-34	134.0	COG0735@1|root,COG0735@2|Bacteria,2GAU1@200795|Chloroflexi,34DHB@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
MMS1_k127_1210523_1	1123274.KB899409_gene569	3.646e-34	135.0	COG0500@1|root,COG2226@2|Bacteria,2J8V8@203691|Spirochaetes	203691|Spirochaetes	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_1211191_0	933262.AXAM01000015_gene101	7.228e-189	595.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,2MIBC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMS1_k127_1211191_1	1121448.DGI_1057	3.491e-17	87.0	2E1K2@1|root,32WXJ@2|Bacteria,1N3MI@1224|Proteobacteria,42UCI@68525|delta/epsilon subdivisions,2WR06@28221|Deltaproteobacteria,2MDKX@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1211191_2	882.DVU_1180	3.259e-13	71.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria,2MD55@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM ThiamineS	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
MMS1_k127_1212539_1	545694.TREPR_1397	1.621e-89	305.0	COG4796@1|root,COG4796@2|Bacteria,2J6K9@203691|Spirochaetes	203691|Spirochaetes	U	Bacterial type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin
MMS1_k127_1212539_0	1123274.KB899436_gene1288	3.222e-150	501.0	COG2804@1|root,COG2804@2|Bacteria,2J5A6@203691|Spirochaetes	203691|Spirochaetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE
MMS1_k127_1212539_2	545694.TREPR_1395	2.311e-28	126.0	COG1459@1|root,COG1459@2|Bacteria,2J7Y9@203691|Spirochaetes	203691|Spirochaetes	U	Bacterial type II secretion system protein F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
MMS1_k127_1212846_6	1121396.KB893066_gene1590	1.167e-21	95.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2MQ1R@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
MMS1_k127_1212846_3	1121396.KB893066_gene1589	5.719e-50	181.0	COG0589@1|root,COG0589@2|Bacteria,1PEB7@1224|Proteobacteria,42XVC@68525|delta/epsilon subdivisions,2WSNF@28221|Deltaproteobacteria,2MMDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS1_k127_1212846_4	694430.Natoc_3739	1.385e-28	125.0	COG0508@1|root,arCOG01706@2157|Archaea,2XUGY@28890|Euryarchaeota,23V33@183963|Halobacteria	183963|Halobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
MMS1_k127_1212846_5	1506583.JQJY01000007_gene4109	8.507e-24	115.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZ3N@117743|Flavobacteriia,2NXGC@237|Flavobacterium	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_1212846_0	1250005.PHEL85_0181	4.845e-176	559.0	COG1234@1|root,COG1262@1|root,COG1234@2|Bacteria,COG1262@2|Bacteria,4NGWF@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566,Lactamase_B_2
MMS1_k127_1212846_2	1415774.U728_959	3.37e-86	298.0	COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,24AQ9@186801|Clostridia,36E26@31979|Clostridiaceae	186801|Clostridia	S	N-methylation of lysine residues in flagellin K00599	-	-	-	ko:K18475	-	-	-	-	ko00000,ko01000,ko02035	-	-	-	CxxCxxCC
MMS1_k127_1212846_1	926550.CLDAP_34260	5.236e-93	319.0	COG0477@1|root,COG2814@2|Bacteria,2G96S@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_1215023_2	1121104.AQXH01000001_gene919	2.156e-26	113.0	COG0775@1|root,COG0775@2|Bacteria,4NMPF@976|Bacteroidetes,1IZ9C@117747|Sphingobacteriia	976|Bacteroidetes	F	Phosphorylase superfamily	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS1_k127_1215023_1	1307761.L21SP2_2893	3.598e-50	183.0	COG0663@1|root,COG0663@2|Bacteria,2J7Q4@203691|Spirochaetes	203691|Spirochaetes	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
MMS1_k127_1215023_0	383372.Rcas_4167	4.157e-115	377.0	COG0366@1|root,COG0366@2|Bacteria,2G7K6@200795|Chloroflexi,374W8@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.1,3.2.1.20,5.4.99.16	ko:K01187,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R01557,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077,RC01816	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Malt_amylase_C
MMS1_k127_1215285_0	1121121.KB894286_gene2501	2.72e-33	135.0	COG0317@1|root,COG0317@2|Bacteria,1VC5K@1239|Firmicutes,4HKVH@91061|Bacilli,26YMH@186822|Paenibacillaceae	91061|Bacilli	KT	COG0317 Guanosine polyphosphate pyrophosphohydrolases synthetases	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
MMS1_k127_1215285_1	484022.Fphi_0614	7.9e-20	89.0	COG2184@1|root,COG2184@2|Bacteria,1R72A@1224|Proteobacteria,1T0D0@1236|Gammaproteobacteria,463JR@72273|Thiotrichales	72273|Thiotrichales	D	Fic/DOC family	-	-	-	ko:K04095	-	-	-	-	ko00000,ko03036	-	-	-	Fic
MMS1_k127_1216618_0	742738.HMPREF9460_02585	1.045e-99	350.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,2682T@186813|unclassified Clostridiales	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
MMS1_k127_122037_1	545694.TREPR_1266	7.434e-36	137.0	COG2025@1|root,COG2025@2|Bacteria,2J5XR@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS1_k127_122037_0	545694.TREPR_1267	8.926e-173	559.0	COG1960@1|root,COG1960@2|Bacteria,2J5X1@203691|Spirochaetes	203691|Spirochaetes	C	Acyl-CoA dehydrogenase, C-terminal domain	fadE	-	-	ko:K15980	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
MMS1_k127_122037_2	1463856.JOHY01000003_gene5109	5.866e-23	102.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_1222102_0	338963.Pcar_1103	1.852e-210	662.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,43TE2@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM AAA ATPase central domain protein	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
MMS1_k127_1222102_5	573413.Spirs_0875	2.839e-28	121.0	2E1WK@1|root,3307R@2|Bacteria,2JBFS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1222102_4	1415775.U729_1444	2.202e-30	128.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
MMS1_k127_1222102_3	1499967.BAYZ01000145_gene6207	2.482e-60	216.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
MMS1_k127_1222102_2	1499967.BAYZ01000145_gene6204	5.413e-84	282.0	COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
MMS1_k127_1222102_1	869213.JCM21142_93862	7.084e-91	303.0	COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,47KHN@768503|Cytophagia	976|Bacteroidetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
MMS1_k127_1226910_6	1232437.KL662015_gene1241	1.479e-49	180.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WMWW@28221|Deltaproteobacteria,2MMSG@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9
MMS1_k127_1226910_1	573413.Spirs_3051	6.004e-150	488.0	COG2925@1|root,COG2925@2|Bacteria,2J9WH@203691|Spirochaetes	203691|Spirochaetes	L	Exonuclease C-terminal	-	-	3.1.11.1	ko:K01141	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_X-T_C,RNase_T
MMS1_k127_1226910_0	509191.AEDB02000002_gene1213	7.947e-165	525.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,24BGZ@186801|Clostridia,3WJAE@541000|Ruminococcaceae	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17,Fer4_9
MMS1_k127_1226910_3	1565314.OA34_03985	4.732e-86	291.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2YMND@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS1_k127_1226910_5	457398.HMPREF0326_01309	4.942e-57	211.0	COG0679@1|root,COG0679@2|Bacteria,1QKS6@1224|Proteobacteria,435R5@68525|delta/epsilon subdivisions,2X05P@28221|Deltaproteobacteria,2MAPN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Auxin Efflux Carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	-
MMS1_k127_1226910_4	1121439.dsat_1065	1.693e-59	216.0	COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,42TIX@68525|delta/epsilon subdivisions,2WP2M@28221|Deltaproteobacteria,2MAUW@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	AraC protein, arabinose-binding	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
MMS1_k127_1226910_2	1265505.ATUG01000001_gene3178	1.687e-86	297.0	COG0697@1|root,COG0697@2|Bacteria,1PX5W@1224|Proteobacteria,42MGR@68525|delta/epsilon subdivisions,2WJSI@28221|Deltaproteobacteria,2MI95@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1226910_7	679926.Mpet_1119	1.086e-36	141.0	COG3943@1|root,arCOG04956@2157|Archaea,2Y2SY@28890|Euryarchaeota	28890|Euryarchaeota	S	Virulence protein RhuM family	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_RhuM
MMS1_k127_1227008_0	33035.JPJF01000035_gene3475	1.162e-171	548.0	COG3345@1|root,COG3345@2|Bacteria,1TSZB@1239|Firmicutes,247VV@186801|Clostridia	186801|Clostridia	G	alpha-galactosidase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
MMS1_k127_1227008_1	180332.JTGN01000006_gene3324	1.312e-155	510.0	COG2972@1|root,COG2972@2|Bacteria,1UQDY@1239|Firmicutes,249HG@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
MMS1_k127_1227008_2	180332.JTGN01000006_gene3323	2.919e-96	337.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQES@1239|Firmicutes,24C3N@186801|Clostridia	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_1227008_3	742733.HMPREF9469_00782	7.263e-84	290.0	COG1653@1|root,COG1653@2|Bacteria,1VTX8@1239|Firmicutes,24ZPV@186801|Clostridia,223EJ@1506553|Lachnoclostridium	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1230605_0	1449063.JMLS01000001_gene4342	1.577e-142	460.0	COG1132@1|root,COG1132@2|Bacteria,1TSY4@1239|Firmicutes,4HAJQ@91061|Bacilli,26R59@186822|Paenibacillaceae	91061|Bacilli	V	ABC-type multidrug transport system, ATPase and permease	lmrA	-	3.6.3.44	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	M00700	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.123,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_1230605_1	1329516.JPST01000061_gene1699	1.383e-66	231.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HBSC@91061|Bacilli,27B8Q@186824|Thermoactinomycetaceae	91061|Bacilli	T	Transcriptional regulatory protein, C terminal	mprA3	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1231456_1	518766.Rmar_1323	3.805e-15	79.0	COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes	976|Bacteroidetes	T	Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	rsbW	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
MMS1_k127_1231456_0	316274.Haur_2871	3.187e-131	425.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi,374WQ@32061|Chloroflexia	32061|Chloroflexia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS1_k127_1232424_3	526218.Sterm_2722	3.21e-19	93.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT,DUF4442,YiiD_C
MMS1_k127_1232424_2	469617.FUAG_02586	6.64e-22	101.0	COG0664@1|root,COG0664@2|Bacteria,37APU@32066|Fusobacteria	32066|Fusobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS1_k127_1232424_0	526222.Desal_1439	4.075e-148	492.0	COG2984@1|root,COG3852@1|root,COG2984@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42YXK@68525|delta/epsilon subdivisions,2WTKM@28221|Deltaproteobacteria,2MH9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4
MMS1_k127_1232930_0	272562.CA_C2936	1.507e-50	189.0	COG0596@1|root,COG0596@2|Bacteria,1U3PB@1239|Firmicutes,24DR6@186801|Clostridia,36GJI@31979|Clostridiaceae	186801|Clostridia	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
MMS1_k127_1232930_2	1131812.JQMS01000001_gene735	2.489e-07	60.0	COG1345@1|root,COG3386@1|root,COG1345@2|Bacteria,COG3386@2|Bacteria,4NM9F@976|Bacteroidetes,1I33Y@117743|Flavobacteriia,2P0DI@237|Flavobacterium	976|Bacteroidetes	GN	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5008,DUF5122,DUF5124
MMS1_k127_1232930_1	1121889.AUDM01000003_gene2406	5.966e-08	62.0	COG3386@1|root,COG4886@1|root,COG3386@2|Bacteria,COG4886@2|Bacteria,4PKPT@976|Bacteroidetes,1IKDI@117743|Flavobacteriia,2P0DY@237|Flavobacterium	976|Bacteroidetes	G	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
MMS1_k127_1235965_9	1033740.CAEW01000004_gene999	1.543e-13	76.0	COG1846@1|root,COG1846@2|Bacteria,1V6EE@1239|Firmicutes,4HJ8T@91061|Bacilli,26FCW@186818|Planococcaceae	91061|Bacilli	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR
MMS1_k127_1235965_7	1121895.Q765_01355	8.178e-29	119.0	2DM4Z@1|root,31R64@2|Bacteria,4NRZQ@976|Bacteroidetes,1I3K5@117743|Flavobacteriia	976|Bacteroidetes	S	DoxX family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,DoxX_2
MMS1_k127_1235965_4	768706.Desor_2594	1.439e-59	208.0	COG3576@1|root,COG3576@2|Bacteria,1V4U5@1239|Firmicutes,24SBM@186801|Clostridia,262YF@186807|Peptococcaceae	186801|Clostridia	S	PFAM pyridoxamine 5'-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
MMS1_k127_1235965_5	1042163.BRLA_c031890	8.644e-54	196.0	COG1182@1|root,COG1182@2|Bacteria,1UZBY@1239|Firmicutes,4HB1Z@91061|Bacilli,275U4@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
MMS1_k127_1235965_8	696281.Desru_3025	1.012e-21	99.0	COG1846@1|root,COG1846@2|Bacteria,1VBQ9@1239|Firmicutes,24P4Y@186801|Clostridia,262VI@186807|Peptococcaceae	186801|Clostridia	K	PFAM MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS1_k127_1235965_3	941449.dsx2_0434	4.965e-65	234.0	COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,43A41@68525|delta/epsilon subdivisions,2X28V@28221|Deltaproteobacteria,2M82D@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM AraC-type transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
MMS1_k127_1235965_6	573413.Spirs_4177	1.158e-44	166.0	COG4925@1|root,COG4925@2|Bacteria,2J7XU@203691|Spirochaetes	203691|Spirochaetes	I	sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1235965_0	768706.Desor_2581	1.876e-214	670.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,2645A@186807|Peptococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
MMS1_k127_1235965_2	1235790.C805_03681	3.412e-122	398.0	COG5434@1|root,COG5434@2|Bacteria,1TQXN@1239|Firmicutes,24APX@186801|Clostridia,25WIA@186806|Eubacteriaceae	186801|Clostridia	M	Protein of unknown function (DUF3737)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3737
MMS1_k127_1235965_1	411474.COPEUT_00602	1.571e-176	561.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia	186801|Clostridia	E	Aminotransferase, class I	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_1236823_3	665571.STHERM_c14190	1.139e-10	69.0	COG1309@1|root,COG1309@2|Bacteria,2J95Q@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1236823_2	83406.HDN1F_37500	9.571e-32	129.0	COG1832@1|root,COG1832@2|Bacteria	2|Bacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
MMS1_k127_1236823_0	1536775.H70737_17135	1.813e-102	347.0	COG3214@1|root,COG3214@2|Bacteria,1TSHT@1239|Firmicutes,4HCCE@91061|Bacilli,26TSW@186822|Paenibacillaceae	91061|Bacilli	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
MMS1_k127_1236823_1	1123274.KB899415_gene2449	4.94e-74	261.0	COG0840@1|root,COG4192@1|root,COG0840@2|Bacteria,COG4192@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K03406,ko:K05875,ko:K07647	ko02020,ko02030,map02020,map02030	M00455	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	4HB_MCP_1,GGDEF,HAMP,HATPase_c,HisKA,MCPsignal,Response_reg,dCache_1,sCache_2
MMS1_k127_12384_7	1123274.KB899418_gene2308	1.271e-31	129.0	COG5005@1|root,COG5005@2|Bacteria	2|Bacteria	S	Phage virion morphogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Phage_tail_S
MMS1_k127_12384_2	1123274.KB899418_gene2311	1.484e-130	422.0	COG4397@1|root,COG4397@2|Bacteria,2J9NF@203691|Spirochaetes	203691|Spirochaetes	S	Mu-like prophage major head subunit gpT	-	-	-	-	-	-	-	-	-	-	-	-	Mu-like_gpT
MMS1_k127_12384_3	1123274.KB899418_gene2312	5.237e-77	269.0	COG4388@1|root,COG4388@2|Bacteria,2JABT@203691|Spirochaetes	203691|Spirochaetes	S	Mu-like prophage I protein	-	-	-	-	-	-	-	-	-	-	-	-	Mu-like_Pro
MMS1_k127_12384_5	1123274.KB899418_gene2314	7.367e-40	154.0	COG4382@1|root,COG4382@2|Bacteria,2JB7S@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF1018)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1018
MMS1_k127_12384_4	1123274.KB899434_gene2046	1.85e-60	214.0	28NH3@1|root,2ZBJ1@2|Bacteria,2JAE7@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF3164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3164
MMS1_k127_12384_1	1123274.KB899418_gene2316	4.487e-132	430.0	COG3267@1|root,COG3267@2|Bacteria,2JA6F@203691|Spirochaetes	203691|Spirochaetes	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
MMS1_k127_12384_0	1123274.KB899418_gene2317	6.781e-157	513.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Mu-transpos_C,rve
MMS1_k127_12384_6	1123274.KB899418_gene2318	5.49e-32	137.0	28HDR@1|root,2Z7QA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3102
MMS1_k127_12384_10	1123274.KB899418_gene2319	1.671e-15	80.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR,Rrf2
MMS1_k127_12384_12	1235800.C819_00522	1.56e-10	69.0	COG1396@1|root,COG1396@2|Bacteria,1VEU8@1239|Firmicutes,24QN0@186801|Clostridia,27QIN@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
MMS1_k127_1238423_0	744872.Spica_1963	7.184e-64	229.0	COG2199@1|root,COG3706@2|Bacteria,2J8FW@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,Response_reg
MMS1_k127_1238423_1	573413.Spirs_1324	1.043e-58	210.0	COG0742@1|root,COG0742@2|Bacteria,2J7B5@203691|Spirochaetes	203691|Spirochaetes	L	RNA methyltransferase, RsmD family	yhhF	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
MMS1_k127_1238423_2	1313292.BCO_0052700	3.973e-32	139.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
MMS1_k127_1238470_7	661478.OP10G_1753	1.455e-32	135.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	3.2.1.73	ko:K01216	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_16
MMS1_k127_1238470_8	1115803.HMPREF1129_2964	1.855e-26	127.0	COG0726@1|root,COG0726@2|Bacteria,2IC87@201174|Actinobacteria,4D5BR@85005|Actinomycetales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
MMS1_k127_1238470_9	1408823.AXUS01000006_gene73	3.148e-09	62.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,25TPZ@186804|Peptostreptococcaceae	186801|Clostridia	T	STAS domain	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
MMS1_k127_1238470_4	1480694.DC28_07825	3.99e-66	245.0	COG2208@1|root,COG2208@2|Bacteria,2JAMR@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
MMS1_k127_1238470_5	646529.Desaci_3402	1.157e-59	227.0	COG0426@1|root,COG0745@1|root,COG2199@1|root,COG0426@2|Bacteria,COG0745@2|Bacteria,COG2199@2|Bacteria,1V80E@1239|Firmicutes,24EX9@186801|Clostridia	186801|Clostridia	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_1238470_1	646529.Desaci_3401	9.006e-159	535.0	COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1
MMS1_k127_1238470_0	632292.Calhy_2486	9.263e-192	627.0	COG0457@1|root,COG0457@2|Bacteria,1TSH7@1239|Firmicutes,248J1@186801|Clostridia	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1238470_6	278957.ABEA03000213_gene3791	5.005e-58	217.0	COG0524@1|root,COG0524@2|Bacteria,46TT7@74201|Verrucomicrobia,3K7V3@414999|Opitutae	414999|Opitutae	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
MMS1_k127_1238470_2	1293054.HSACCH_02508	2.478e-109	364.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,3WBH0@53433|Halanaerobiales	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
MMS1_k127_1238470_3	1042377.AFPJ01000037_gene2868	1.579e-102	337.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,4650X@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	GO:0003674,GO:0003824,GO:0004844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS1_k127_1247279_1	335543.Sfum_0958	5.062e-19	92.0	COG3919@1|root,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,42U1R@68525|delta/epsilon subdivisions,2X2JR@28221|Deltaproteobacteria,2MS8F@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1247279_0	335543.Sfum_0956	6.249e-87	295.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
MMS1_k127_1247279_2	390989.JOEG01000014_gene3143	4.065e-13	79.0	COG0500@1|root,COG2226@2|Bacteria,2IGXK@201174|Actinobacteria,4DI27@85008|Micromonosporales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_125054_3	1267535.KB906767_gene2909	4.134e-07	59.0	COG1309@1|root,COG1309@2|Bacteria,3Y4GK@57723|Acidobacteria,2JP48@204432|Acidobacteriia	204432|Acidobacteriia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_125054_0	573413.Spirs_1638	1.291e-159	516.0	COG1129@1|root,COG1129@2|Bacteria,2JA37@203691|Spirochaetes	203691|Spirochaetes	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_125054_1	1123274.KB899413_gene780	1.239e-71	251.0	COG1349@1|root,COG1349@2|Bacteria,2JAE3@203691|Spirochaetes	203691|Spirochaetes	K	DeoR C terminal sensor domain	-	-	-	ko:K22103	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
MMS1_k127_125054_2	573413.Spirs_1636	8.997e-62	216.0	COG4213@1|root,COG4213@2|Bacteria,2J5TP@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
MMS1_k127_1250600_5	1007103.AFHW01000010_gene6110	3.28e-11	64.0	COG0583@1|root,COG0583@2|Bacteria,1TST3@1239|Firmicutes,4HDBC@91061|Bacilli,26TJF@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1250600_0	1443125.Z962_08970	8.534e-139	457.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1250600_1	1027292.HMPREF9372_1155	5.98e-58	213.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26EGR@186818|Planococcaceae	91061|Bacilli	G	COG1172 Ribose xylose arabinose galactoside ABC-type transport systems, permease components	rbsC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_1250600_2	397287.C807_03244	7.348e-37	152.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,27II3@186928|unclassified Lachnospiraceae	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
MMS1_k127_1250600_3	1027292.HMPREF9372_1154	2.029e-21	106.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,4HCSN@91061|Bacilli,26CZH@186818|Planococcaceae	91061|Bacilli	G	Periplasmic binding protein domain	rbsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1250600_4	1306990.BARG01000031_gene3455	1.798e-15	84.0	2DVYA@1|root,33XPC@2|Bacteria,2IACR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1251190_0	187272.Mlg_2345	6.462e-221	701.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1WWRV@135613|Chromatiales	135613|Chromatiales	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
MMS1_k127_1251190_2	1237149.C900_03114	4.723e-67	237.0	COG1218@1|root,COG1218@2|Bacteria,4NFHY@976|Bacteroidetes,47PAU@768503|Cytophagia	976|Bacteroidetes	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
MMS1_k127_1251190_1	626887.J057_18155	4.642e-127	412.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,1RNAD@1236|Gammaproteobacteria,464C9@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes	cysD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_1303	PAPS_reduct
MMS1_k127_1251190_3	1121396.KB892990_gene4510	6.656e-60	222.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MNE6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sterol-sensing domain of SREBP cleavage-activation	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_1254560_10	7091.BGIBMGA012527-TA	7.767e-27	118.0	COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta,3BACQ@33208|Metazoa,3CSEJ@33213|Bilateria,41TKY@6656|Arthropoda,3SQU6@50557|Insecta,444KA@7088|Lepidoptera	33208|Metazoa	Q	short chain dehydrogenase	-	-	1.1.1.300	ko:K11153	ko00830,ko01100,map00830,map01100	-	R08379,R08383	RC00649	ko00000,ko00001,ko01000	-	-	-	adh_short
MMS1_k127_1254560_13	983917.RGE_34140	7.183e-08	65.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,1KK8S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulator, Crp Fnr family	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
MMS1_k127_1254560_12	237368.SCABRO_00465	1.151e-10	74.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_1254560_6	1151119.KB895488_gene1042	6.476e-46	175.0	2E8YV@1|root,3338H@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1254560_7	1265505.ATUG01000002_gene1501	1.141e-35	138.0	COG3370@1|root,COG3370@2|Bacteria,1N27G@1224|Proteobacteria,42TID@68525|delta/epsilon subdivisions,2X5QM@28221|Deltaproteobacteria,2MM1R@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS1_k127_1254560_3	1294265.JCM21738_4920	8.839e-77	260.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,1ZDT7@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
MMS1_k127_1254560_2	1123274.KB899410_gene3410	4.356e-119	389.0	COG3384@1|root,COG3384@2|Bacteria,2JA2G@203691|Spirochaetes	203691|Spirochaetes	S	Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B	-	-	-	-	-	-	-	-	-	-	-	-	LigB
MMS1_k127_1254560_8	395493.BegalDRAFT_1227	8.825e-34	143.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,1RNUW@1236|Gammaproteobacteria,463EF@72273|Thiotrichales	1224|Proteobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
MMS1_k127_1254560_5	1120970.AUBZ01000013_gene1826	8.542e-51	188.0	2DBP0@1|root,2ZA6P@2|Bacteria,1NXFM@1224|Proteobacteria,1SQNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1254560_9	1307761.L21SP2_0791	1.013e-31	142.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	aml1	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,CBM_25,CBM_35,CHB_HEX_C_1,fn3
MMS1_k127_1254560_1	1123228.AUIH01000001_gene1297	7.527e-148	487.0	COG0366@1|root,COG1874@1|root,COG0366@2|Bacteria,COG1874@2|Bacteria,1R8CV@1224|Proteobacteria,1S0MI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glycosyl hydrolase family 14	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_14
MMS1_k127_1254560_4	889378.Spiaf_0512	1.413e-69	250.0	COG1609@1|root,COG1609@2|Bacteria,2J7R5@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1254560_11	1307761.L21SP2_0791	9.317e-27	128.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	aml1	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CBM26,CBM53,CBM_25,CBM_35,CHB_HEX_C_1,fn3
MMS1_k127_1254560_0	1200567.JNKD01000014_gene933	8.068e-196	634.0	COG0366@1|root,COG1523@1|root,COG0366@2|Bacteria,COG1523@2|Bacteria,1MVQA@1224|Proteobacteria,1RPA4@1236|Gammaproteobacteria,1Y562@135624|Aeromonadales	135624|Aeromonadales	G	Aamy_C	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,PKD
MMS1_k127_1255330_2	402881.Plav_1591	2.002e-18	89.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,1JNRV@119043|Rhodobiaceae	28211|Alphaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
MMS1_k127_1255330_0	744872.Spica_0853	2.131e-274	859.0	COG0480@1|root,COG0480@2|Bacteria,2J5D3@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_1255330_1	573413.Spirs_2536	2.22e-172	556.0	COG0480@1|root,COG0480@2|Bacteria,2J5YJ@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_1255391_3	1031288.AXAA01000019_gene1066	1.935e-21	94.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,36DGP@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS1_k127_1255391_2	411468.CLOSCI_00801	3.893e-53	194.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,220S6@1506553|Lachnoclostridium	186801|Clostridia	G	COG COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
MMS1_k127_1255391_0	1280390.CBQR020000164_gene4355	1.358e-207	655.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,4HVE0@91061|Bacilli,271P8@186822|Paenibacillaceae	91061|Bacilli	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS1_k127_1255391_1	1294142.CINTURNW_0640	3.922e-202	642.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_1257301_0	1385511.N783_18655	2.482e-95	321.0	COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,4HBEF@91061|Bacilli,2YAFJ@289201|Pontibacillus	91061|Bacilli	U	ABC transporter	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1257301_1	1480694.DC28_15315	4.325e-86	300.0	COG1940@1|root,COG1940@2|Bacteria,2J8MA@203691|Spirochaetes	203691|Spirochaetes	GK	ROK family	xylR-1	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
MMS1_k127_1257780_1	665571.STHERM_c09210	1.412e-87	297.0	COG1360@1|root,COG1360@2|Bacteria,2J68Q@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar motor protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
MMS1_k127_1257780_2	1480694.DC28_02375	1.502e-64	224.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
MMS1_k127_1257780_9	1125699.HMPREF9194_00946	1.611e-09	61.0	COG1291@1|root,COG1291@2|Bacteria,2J5HT@203691|Spirochaetes	203691|Spirochaetes	N	MotA TolQ ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
MMS1_k127_1257780_6	889378.Spiaf_2096	3.818e-23	99.0	COG1582@1|root,COG1582@2|Bacteria,2J8UC@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar protein FlbD	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
MMS1_k127_1257780_0	1123274.KB899413_gene847	1.848e-222	696.0	COG1749@1|root,COG1749@2|Bacteria,2J5H4@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook protein flgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
MMS1_k127_1257780_4	744872.Spica_1538	8.833e-44	163.0	COG1843@1|root,COG1843@2|Bacteria,2J806@203691|Spirochaetes	203691|Spirochaetes	N	flagellar hook	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgD
MMS1_k127_1257780_8	869209.Tresu_1555	3.56e-10	72.0	COG3144@1|root,COG3144@2|Bacteria,2J88U@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-length control protein	fliK	-	-	ko:K02384,ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
MMS1_k127_1257780_3	768704.Desmer_2155	1.676e-59	212.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,24UEG@186801|Clostridia,262DI@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
MMS1_k127_1257780_7	755731.Clo1100_3373	6.502e-12	72.0	2AHJF@1|root,317X5@2|Bacteria,1W3CX@1239|Firmicutes,2564T@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1257780_5	1123242.JH636434_gene3850	2.957e-24	112.0	2DWIV@1|root,340JE@2|Bacteria,2J38D@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1259399_3	1480694.DC28_07920	6.853e-34	137.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding,DUF2442
MMS1_k127_1259399_1	573413.Spirs_0094	1.368e-94	320.0	COG0639@1|root,COG0639@2|Bacteria,2J6GE@203691|Spirochaetes	203691|Spirochaetes	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
MMS1_k127_1259399_0	1123274.KB899407_gene384	6.101e-144	477.0	COG0515@1|root,COG0515@2|Bacteria,2J6N6@203691|Spirochaetes	203691|Spirochaetes	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMS1_k127_1259399_2	889378.Spiaf_2847	1.421e-50	190.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,RDD,Yop-YscD_cpl
MMS1_k127_1259399_4	889378.Spiaf_2848	6.96e-30	127.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2,zinc_ribbon_2
MMS1_k127_1260733_2	1307761.L21SP2_3395	1.845e-66	228.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	ycjP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1260733_0	857293.CAAU_1117	4.685e-187	600.0	COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,24AB0@186801|Clostridia,36FBK@31979|Clostridiaceae	186801|Clostridia	G	Sucrose phosphorylase	-	-	2.4.1.329,2.4.1.7	ko:K00690,ko:K21350	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
MMS1_k127_1260733_1	665571.STHERM_c00340	2.976e-174	557.0	COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS1_k127_1260733_3	1294142.CINTURNW_1177	5.253e-41	162.0	COG2199@1|root,COG2199@2|Bacteria,1TT99@1239|Firmicutes,24CR1@186801|Clostridia,36KG9@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM
MMS1_k127_1262910_0	710421.Mycch_3631	1.549e-08	64.0	COG1309@1|root,COG1309@2|Bacteria,2H131@201174|Actinobacteria,232TI@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1262910_1	44251.PDUR_22120	0.0001233	46.0	COG1335@1|root,COG1335@2|Bacteria,1V7B8@1239|Firmicutes,4HJEA@91061|Bacilli,26WTP@186822|Paenibacillaceae	91061|Bacilli	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS1_k127_1263667_0	1196323.ALKF01000177_gene1073	1.946e-249	785.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26QYB@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	yfiC	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_1263667_1	941824.TCEL_00959	4.183e-33	129.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_1266360_3	74547.PMT_1811	3.877e-12	78.0	COG0457@1|root,COG0457@2|Bacteria,1G36K@1117|Cyanobacteria	1117|Cyanobacteria	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8
MMS1_k127_1266360_1	665571.STHERM_c06950	1.992e-38	150.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	-	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding,DUF2442
MMS1_k127_1266360_2	1217705.F900_02972	1.112e-14	82.0	COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,1S3GK@1236|Gammaproteobacteria,3NJ8C@468|Moraxellaceae	1236|Gammaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
MMS1_k127_1266360_0	161156.JQKW01000006_gene1070	3.668e-63	230.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
MMS1_k127_1267641_5	880073.Calab_0504	2.153e-16	81.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS1_k127_1267641_4	452471.Aasi_0854	2.514e-20	96.0	COG0790@1|root,COG0790@2|Bacteria,4NMCC@976|Bacteroidetes,47QS2@768503|Cytophagia	976|Bacteroidetes	KLT	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Pkinase,Sel1,Tox-ODYAM1,U-box
MMS1_k127_1267641_0	1123274.KB899409_gene500	6.088e-171	544.0	COG1454@1|root,COG1454@2|Bacteria,2J72Q@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS1_k127_1267641_2	352165.HMPREF7215_1596	3.254e-50	186.0	COG0613@1|root,COG0613@2|Bacteria,3TB0X@508458|Synergistetes	508458|Synergistetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
MMS1_k127_1267641_1	1297570.MESS4_310054	1.16e-80	285.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43P3N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	ugpC	-	3.6.3.20	ko:K05816	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1.3	-	-	ABC_tran,TOBE_2
MMS1_k127_1267641_3	335541.Swol_2477	1.589e-24	105.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia,42KTQ@68298|Syntrophomonadaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
MMS1_k127_1268681_0	1249627.D779_2629	5.234e-142	467.0	COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,1RNZU@1236|Gammaproteobacteria,1WXEZ@135613|Chromatiales	135613|Chromatiales	K	PFAM Ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
MMS1_k127_1269404_2	1304885.AUEY01000047_gene84	2.852e-58	209.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1269404_1	357809.Cphy_1698	2.801e-161	516.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia	186801|Clostridia	P	Arsenite-activated ATPase (ArsA)	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
MMS1_k127_1269404_0	357809.Cphy_1697	9.805e-171	544.0	COG0003@1|root,COG0071@1|root,COG0003@2|Bacteria,COG0071@2|Bacteria,1UKBM@1239|Firmicutes,24AYR@186801|Clostridia	186801|Clostridia	P	Arsenite-activated ATPase (ArsA)	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
MMS1_k127_1269404_3	1469948.JPNB01000001_gene829	9.489e-39	150.0	COG1846@1|root,COG1846@2|Bacteria,1VBBG@1239|Firmicutes,24N9X@186801|Clostridia,36JD4@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR
MMS1_k127_1269404_4	1108045.GORHZ_150_00010	1.649e-32	131.0	arCOG07533@1|root,2ZF5I@2|Bacteria,2IMPX@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
MMS1_k127_1272176_2	941824.TCEL_01595	7.826e-14	74.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,36FRE@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
MMS1_k127_1272176_1	649639.Bcell_3171	2.628e-39	160.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HGGE@91061|Bacilli,1ZF4B@1386|Bacillus	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1272176_0	1414720.CBYM010000012_gene2555	5.818e-72	254.0	COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,249GM@186801|Clostridia,36DK1@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
MMS1_k127_1275697_1	1333507.AUTQ01000069_gene2165	2.525e-58	215.0	COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,1T257@1236|Gammaproteobacteria,2Q0EY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,DUF3369,HD,HD_5,Response_reg
MMS1_k127_1275697_0	1167006.UWK_00502	4.723e-281	874.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2MI51@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1259	ILVD_EDD
MMS1_k127_1278820_6	1329516.JPST01000014_gene577	2.514e-07	55.0	2C3VR@1|root,2Z9AE@2|Bacteria,1UZNB@1239|Firmicutes,4HJP2@91061|Bacilli,27BWZ@186824|Thermoactinomycetaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1278820_1	1304284.L21TH_0215	6.81e-177	563.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,36E9A@31979|Clostridiaceae	186801|Clostridia	E	lysine 2,3-aminomutase YodO family protein	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
MMS1_k127_1278820_2	28115.HR11_03500	1.019e-142	460.0	COG0604@1|root,COG0604@2|Bacteria,4NE6Y@976|Bacteroidetes,2FRBA@200643|Bacteroidia,22XG0@171551|Porphyromonadaceae	976|Bacteroidetes	C	Dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	ADH_zinc_N
MMS1_k127_1278820_5	1157490.EL26_10425	2.306e-90	306.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,4HASC@91061|Bacilli,2792V@186823|Alicyclobacillaceae	91061|Bacilli	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
MMS1_k127_1278820_4	944480.ATUV01000001_gene603	2.114e-101	336.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,42R4B@68525|delta/epsilon subdivisions,2WMZN@28221|Deltaproteobacteria,2M734@213113|Desulfurellales	28221|Deltaproteobacteria	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
MMS1_k127_1278820_3	1210884.HG799463_gene10153	4.128e-115	379.0	COG1788@1|root,COG1788@2|Bacteria	2|Bacteria	I	CoA-transferase activity	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
MMS1_k127_1278820_0	706587.Desti_1824	8.901e-180	571.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42NVU@68525|delta/epsilon subdivisions,2WMH6@28221|Deltaproteobacteria,2MRNF@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.111,5.4.3.8	ko:K01845,ko:K07257,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,CTP_transf_3
MMS1_k127_1279014_1	933262.AXAM01000046_gene123	4.918e-216	685.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
MMS1_k127_1279014_4	1123252.ATZF01000012_gene3744	5.077e-145	475.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,27BEJ@186824|Thermoactinomycetaceae	91061|Bacilli	J	GatB domain	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
MMS1_k127_1279014_3	665571.STHERM_c22200	8.39e-151	489.0	COG0154@1|root,COG0154@2|Bacteria,2J58P@203691|Spirochaetes	203691|Spirochaetes	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
MMS1_k127_1279014_5	1123274.KB899411_gene3028	4.145e-21	95.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
MMS1_k127_1279014_2	880073.Calab_2883	1.692e-182	582.0	COG0493@1|root,COG0493@2|Bacteria,2NNUI@2323|unclassified Bacteria	2|Bacteria	E	Flavin containing amine oxidoreductase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
MMS1_k127_1279014_0	1123274.KB899424_gene2967	0.0	1286.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2J5WW@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
MMS1_k127_1281458_0	1123277.KB893173_gene1828	1.443e-84	287.0	COG4948@1|root,COG4948@2|Bacteria,4NFHR@976|Bacteroidetes,47KJ8@768503|Cytophagia	976|Bacteroidetes	M	PFAM Mandelate racemase muconate lactonizing	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS1_k127_1281458_1	742733.HMPREF9469_03722	3.926e-54	201.0	COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C5A@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_1281458_2	749414.SBI_07732	7.635e-35	139.0	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
MMS1_k127_1284811_3	706587.Desti_0884	5.234e-48	185.0	COG0523@1|root,COG0523@2|Bacteria	2|Bacteria	P	cobalamin synthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMS1_k127_1284811_1	158190.SpiGrapes_2634	2.117e-66	244.0	COG0642@1|root,COG2205@2|Bacteria,2J7ZP@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_1284811_2	255470.cbdbA1032	1.712e-59	213.0	COG0745@1|root,COG0745@2|Bacteria,2G6JT@200795|Chloroflexi,34CJN@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1284811_4	868595.Desca_2408	2.881e-39	154.0	COG3212@1|root,COG3212@2|Bacteria,1VJGF@1239|Firmicutes,24RQ9@186801|Clostridia,262RI@186807|Peptococcaceae	186801|Clostridia	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1284811_6	224325.AF_0190	9.216e-23	104.0	COG2010@1|root,arCOG06111@2157|Archaea,2XXGW@28890|Euryarchaeota,2469C@183980|Archaeoglobi	183980|Archaeoglobi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
MMS1_k127_1284811_0	1123274.KB899421_gene1802	2.336e-166	535.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
MMS1_k127_1284811_5	754027.HMPREF9554_02059	1.216e-29	124.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
MMS1_k127_1285511_0	309799.DICTH_1964	4.977e-116	382.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_1285511_1	886293.Sinac_2614	7.957e-32	128.0	COG1721@1|root,COG1721@2|Bacteria,2IY59@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_1286662_0	1121918.ARWE01000001_gene1660	7.452e-62	220.0	COG0454@1|root,COG4191@1|root,COG0456@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,BKACE,GAF,GAF_2,GGDEF,HATPase_c,PAS_3,PAS_4,PAS_9,dCache_1
MMS1_k127_1286662_1	1294142.CINTURNW_1944	1.303e-38	151.0	COG0693@1|root,COG0693@2|Bacteria,1V5HS@1239|Firmicutes,24KRV@186801|Clostridia	186801|Clostridia	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
MMS1_k127_1286662_2	869209.Tresu_1565	2.271e-16	83.0	COG0681@1|root,COG0681@2|Bacteria,2J6RU@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB-2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
MMS1_k127_1286856_3	536232.CLM_0597	3.12e-69	244.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,36DXS@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
MMS1_k127_1286856_0	1321815.HMPREF9193_01778	1.85e-201	636.0	COG0282@1|root,COG0282@2|Bacteria,2J57M@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
MMS1_k127_1286856_5	573413.Spirs_2243	3.925e-60	213.0	COG0693@1|root,COG0693@2|Bacteria,2J8IJ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM DJ-1 family protein	thiJ	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
MMS1_k127_1286856_4	1121468.AUBR01000006_gene385	2.669e-65	232.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,42FXU@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
MMS1_k127_1286856_2	573413.Spirs_3800	1.677e-152	501.0	COG0513@1|root,COG0513@2|Bacteria,2J5U7@203691|Spirochaetes	203691|Spirochaetes	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
MMS1_k127_1286856_1	744872.Spica_1199	2.454e-199	639.0	COG1154@1|root,COG1154@2|Bacteria,2J5NP@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
MMS1_k127_1286856_6	158190.SpiGrapes_3233	3.336e-13	70.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
MMS1_k127_1287598_0	665571.STHERM_c14690	3.975e-193	609.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	GH43_C,Glyco_hydro_43
MMS1_k127_1287598_1	1121926.AXWO01000008_gene2926	7.083e-191	608.0	COG3534@1|root,COG3534@2|Bacteria,2GMAK@201174|Actinobacteria	201174|Actinobacteria	G	alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
MMS1_k127_1288271_1	869213.JCM21142_3824	1.844e-51	184.0	COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,47QE4@768503|Cytophagia	976|Bacteroidetes	J	TIGRFAM endoribonuclease L-PSP	ridA	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
MMS1_k127_1288271_0	1123274.KB899407_gene322	9.026e-173	556.0	COG1492@1|root,COG1492@2|Bacteria,2J70P@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiA,GATase_3
MMS1_k127_1288271_2	262724.TT_P0019	4.984e-05	51.0	COG1270@1|root,COG1270@2|Bacteria,1WJQ2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
MMS1_k127_1293769_2	913865.DOT_6228	5.402e-37	152.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,261S1@186807|Peptococcaceae	186801|Clostridia	T	Membrane-associated sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	DegV,HATPase_c,HisKA,Hpt,Reg_prop,Response_reg,dCache_1
MMS1_k127_1293769_1	907348.TresaDRAFT_0779	1.724e-51	192.0	COG1385@1|root,COG1385@2|Bacteria,2J81V@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
MMS1_k127_1293769_0	665571.STHERM_c01850	2.4e-70	245.0	COG0159@1|root,COG0159@2|Bacteria,2J6HT@203691|Spirochaetes	203691|Spirochaetes	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
MMS1_k127_1294134_1	545694.TREPR_1758	1.31e-36	142.0	COG0130@1|root,COG0130@2|Bacteria,2J7Q2@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
MMS1_k127_1294134_2	1480694.DC28_02025	4.194e-30	123.0	COG0858@1|root,COG0858@2|Bacteria	2|Bacteria	J	rRNA processing	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
MMS1_k127_1294134_0	1480694.DC28_02030	9.661e-161	512.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
MMS1_k127_1302212_3	28072.Nos7524_0233	1.106e-09	62.0	COG4453@1|root,COG4453@2|Bacteria,1GB3G@1117|Cyanobacteria,1HPD0@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF1778)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
MMS1_k127_1302212_0	118168.MC7420_4196	7.061e-42	159.0	COG0454@1|root,COG0456@2|Bacteria,1G7AI@1117|Cyanobacteria,1HHFX@1150|Oscillatoriales	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
MMS1_k127_1302212_1	1173027.Mic7113_4479	4.848e-19	88.0	COG1724@1|root,COG1724@2|Bacteria,1G92Z@1117|Cyanobacteria,1HG5T@1150|Oscillatoriales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
MMS1_k127_1302212_2	1173027.Mic7113_4478	3.4e-16	81.0	COG1598@1|root,COG1598@2|Bacteria,1G9GK@1117|Cyanobacteria,1HDFJ@1150|Oscillatoriales	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
MMS1_k127_1306007_1	545695.TREAZ_0914	4.12e-61	220.0	2EY48@1|root,33UVP@2|Bacteria,2J5KT@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar filament outer layer protein FlaA	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
MMS1_k127_1306007_0	573413.Spirs_2586	2.031e-94	315.0	2EY48@1|root,33RD4@2|Bacteria,2J65N@203691|Spirochaetes	203691|Spirochaetes	N	flagellar filament outer layer protein	-	-	-	-	-	-	-	-	-	-	-	-	FlaA
MMS1_k127_1306007_2	1480694.DC28_02705	3.845e-11	66.0	COG0664@1|root,COG4191@1|root,COG0664@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	hoxI	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	EAL,FliG_C,HATPase_c,HisKA,cNMP_binding
MMS1_k127_1306506_1	926550.CLDAP_40150	5.612e-169	549.0	COG1164@1|root,COG1164@2|Bacteria,2G5UV@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
MMS1_k127_1306506_2	441769.ABFU01000045_gene3112	9.116e-114	371.0	COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,4HA3H@91061|Bacilli,1ZCKZ@1386|Bacillus	91061|Bacilli	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
MMS1_k127_1306506_5	768704.Desmer_3203	1.021e-50	196.0	COG2199@1|root,COG2199@2|Bacteria,1TT99@1239|Firmicutes,24CR1@186801|Clostridia,265B6@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM
MMS1_k127_1306506_10	889378.Spiaf_0238	0.0009222	42.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1306506_3	1480694.DC28_04130	1.007e-65	230.0	COG1272@1|root,COG1272@2|Bacteria,2J5IS@203691|Spirochaetes	203691|Spirochaetes	S	channel protein, hemolysin III family	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
MMS1_k127_1306506_9	877455.Metbo_2145	7.332e-16	81.0	COG1917@1|root,arCOG02992@2157|Archaea,2XZHW@28890|Euryarchaeota	28890|Euryarchaeota	G	PFAM Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_1306506_0	177437.HRM2_40600	5.992e-251	789.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria,2MHVG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2834	Prismane
MMS1_k127_1306506_6	1307761.L21SP2_0513	9.484e-49	182.0	COG0664@1|root,COG0664@2|Bacteria,2J6BZ@203691|Spirochaetes	203691|Spirochaetes	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_1306506_7	744872.Spica_2862	4.596e-42	164.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Glucosaminidase,NLPC_P60,Peptidase_M15_4,SLH
MMS1_k127_1306506_4	1144319.PMI16_03071	1.485e-53	191.0	COG3832@1|root,COG3832@2|Bacteria,1RDAM@1224|Proteobacteria,2VT05@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS1_k127_1306506_8	522772.Dacet_0404	5.438e-19	91.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
MMS1_k127_1308621_3	1417296.U879_03685	4.179e-36	143.0	COG0500@1|root,COG2226@2|Bacteria,1R41W@1224|Proteobacteria,2UJDA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_1308621_1	744872.Spica_1887	7.884e-85	296.0	COG0477@1|root,COG2814@2|Bacteria,2JAJU@203691|Spirochaetes	203691|Spirochaetes	EGP	Major Facilitator Superfamily	-	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1
MMS1_k127_1308621_0	1552123.EP57_14700	1.207e-102	338.0	COG1028@1|root,COG1028@2|Bacteria,1V2UZ@1239|Firmicutes,4HGT2@91061|Bacilli,26MU3@186820|Listeriaceae	91061|Bacilli	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_1308621_2	1321815.HMPREF9193_01628	4.033e-53	190.0	COG2703@1|root,COG2703@2|Bacteria,2J7CC@203691|Spirochaetes	203691|Spirochaetes	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
MMS1_k127_1308621_5	555088.DealDRAFT_2640	5.755e-10	66.0	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia,42KGN@68298|Syntrophomonadaceae	186801|Clostridia	N	PFAM flagellar motor switch protein FliG	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
MMS1_k127_1308621_4	1417296.U879_02280	9.832e-14	73.0	COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_39710	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1308964_0	572544.Ilyop_1591	2.001e-90	306.0	COG1149@1|root,COG1149@2|Bacteria,379V4@32066|Fusobacteria	32066|Fusobacteria	C	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
MMS1_k127_1308964_1	572544.Ilyop_1590	2.729e-89	303.0	COG1149@1|root,COG1149@2|Bacteria,37895@32066|Fusobacteria	32066|Fusobacteria	C	NUBPL iron-transfer P-loop NTPase	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
MMS1_k127_1308964_4	1347392.CCEZ01000016_gene2874	2.503e-19	92.0	COG1433@1|root,COG1433@2|Bacteria,1VFDZ@1239|Firmicutes,24R8N@186801|Clostridia,36JS1@31979|Clostridiaceae	186801|Clostridia	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
MMS1_k127_1308964_5	1304284.L21TH_1712	3.038e-13	72.0	2B25P@1|root,31UNY@2|Bacteria,1URPP@1239|Firmicutes,24UZ1@186801|Clostridia,36P1Y@31979|Clostridiaceae	186801|Clostridia	S	Family of unknown function (DUF5320)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5320
MMS1_k127_1308964_2	1408439.JHXW01000011_gene183	7.664e-39	148.0	COG1342@1|root,COG1433@1|root,COG1342@2|Bacteria,COG1433@2|Bacteria,37AEX@32066|Fusobacteria	32066|Fusobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
MMS1_k127_1308964_7	545694.TREPR_2693	1.979e-06	57.0	COG1413@1|root,COG1413@2|Bacteria,2J61J@203691|Spirochaetes	203691|Spirochaetes	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
MMS1_k127_1308964_3	1121423.JONT01000001_gene1888	3.554e-38	146.0	COG1917@1|root,COG1917@2|Bacteria,1VDBA@1239|Firmicutes,24NXM@186801|Clostridia,262NC@186807|Peptococcaceae	186801|Clostridia	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_1308964_6	1033743.CAES01000090_gene4108	1.509e-09	59.0	COG5002@1|root,COG5002@2|Bacteria,1UJ5U@1239|Firmicutes,4HG8M@91061|Bacilli,26S07@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
MMS1_k127_1310395_4	1499967.BAYZ01000028_gene1254	6.373e-06	49.0	COG2055@1|root,COG2055@2|Bacteria,2NQ9A@2323|unclassified Bacteria	2|Bacteria	C	Malate/L-lactate dehydrogenase	comC	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
MMS1_k127_1310395_3	1499967.BAYZ01000028_gene1254	5.602e-08	57.0	COG2055@1|root,COG2055@2|Bacteria,2NQ9A@2323|unclassified Bacteria	2|Bacteria	C	Malate/L-lactate dehydrogenase	comC	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
MMS1_k127_1310395_0	158189.SpiBuddy_0717	1.109e-55	203.0	COG1802@1|root,COG1802@2|Bacteria,2JAV6@203691|Spirochaetes	203691|Spirochaetes	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_1310395_1	1499967.BAYZ01000088_gene5119	1.106e-38	162.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_1310395_2	665571.STHERM_c06440	1.503e-13	75.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	ycjO	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02025,ko:K02026,ko:K10118,ko:K10233,ko:K15771,ko:K17316	ko02010,map02010	M00196,M00201,M00207,M00491,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.24,3.A.1.1.28,3.A.1.1.30,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
MMS1_k127_1311873_1	1123274.KB899430_gene1682	6.503e-162	521.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
MMS1_k127_1311873_3	469616.FMAG_01016	5.327e-30	130.0	COG0517@1|root,COG1762@1|root,COG0517@2|Bacteria,COG1762@2|Bacteria,379JW@32066|Fusobacteria	32066|Fusobacteria	GT	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	CBS,PTS_EIIA_2
MMS1_k127_1311873_0	1480694.DC28_15420	3.314e-165	529.0	COG1055@1|root,COG1055@2|Bacteria,2J6QU@203691|Spirochaetes	203691|Spirochaetes	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,Na_sulph_symp
MMS1_k127_1311873_2	158190.SpiGrapes_2035	2.864e-54	199.0	28P0Q@1|root,2ZBX8@2|Bacteria,2JATM@203691|Spirochaetes	203691|Spirochaetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1314976_4	573413.Spirs_3012	5.144e-20	93.0	COG4149@1|root,COG4149@2|Bacteria,2J7X7@203691|Spirochaetes	203691|Spirochaetes	P	COG4149 ABC-type molybdate transport system, permease component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
MMS1_k127_1314976_1	573413.Spirs_3011	7.448e-71	248.0	COG0725@1|root,COG0725@2|Bacteria,2J716@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
MMS1_k127_1314976_2	744872.Spica_1571	4.516e-36	143.0	COG0716@1|root,COG0716@2|Bacteria,2J9HA@203691|Spirochaetes	203691|Spirochaetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1314976_3	1123274.KB899426_gene2832	1.378e-23	109.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	GO:0000166,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0017076,GO:0019219,GO:0019222,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0046983,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_1314976_0	665571.STHERM_c15820	1.896e-96	327.0	COG0337@1|root,COG0337@2|Bacteria,2J69J@203691|Spirochaetes	203691|Spirochaetes	H	3-dehydroquinate synthase	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
MMS1_k127_1315935_3	573413.Spirs_1542	5.09e-19	88.0	COG1543@1|root,COG1543@2|Bacteria,2J628@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
MMS1_k127_1315935_2	744872.Spica_1689	2.583e-42	159.0	COG2001@1|root,COG2001@2|Bacteria,2J7XS@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
MMS1_k127_1315935_0	1124982.MSI_17470	9.82e-113	372.0	COG0275@1|root,COG0275@2|Bacteria,2J6DH@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
MMS1_k127_1315935_4	754027.HMPREF9554_00196	2.126e-10	64.0	2BPMB@1|root,32IEC@2|Bacteria,2J8ZG@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein, FtsL	-	-	-	-	-	-	-	-	-	-	-	-	DivIC,FtsL
MMS1_k127_1315935_1	869209.Tresu_1596	4.239e-66	235.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS1_k127_1315953_3	91464.S7335_4842	1.835e-10	64.0	COG1296@1|root,COG1296@2|Bacteria,1GA6Q@1117|Cyanobacteria	1117|Cyanobacteria	E	branched-chain amino acid permease (azaleucine resistance)	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
MMS1_k127_1315953_2	177437.HRM2_12580	1.748e-18	92.0	COG4392@1|root,COG4392@2|Bacteria,1NAPF@1224|Proteobacteria,432FK@68525|delta/epsilon subdivisions,2WXDN@28221|Deltaproteobacteria,2MME1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
MMS1_k127_1315953_4	1380394.JADL01000002_gene1746	4.766e-10	70.0	COG1262@1|root,COG2114@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,2JS16@204441|Rhodospirillales	204441|Rhodospirillales	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
MMS1_k127_1315953_1	642492.Clole_1909	4.535e-45	171.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_1315953_0	1307761.L21SP2_0997	1.918e-95	328.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1317211_1	665571.STHERM_c00320	0.0001684	50.0	COG0204@1|root,COG0204@2|Bacteria,2JAJG@203691|Spirochaetes	203691|Spirochaetes	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
MMS1_k127_1317211_0	1033810.HLPCO_002490	9.37e-57	207.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
MMS1_k127_1317831_0	744872.Spica_2164	2.292e-123	401.0	COG2855@1|root,COG2855@2|Bacteria,2J8M8@203691|Spirochaetes	203691|Spirochaetes	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
MMS1_k127_1317831_4	1047013.AQSP01000138_gene1035	2.304e-31	140.0	COG1032@1|root,COG1032@2|Bacteria,2NQU0@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
MMS1_k127_1317831_2	177437.HRM2_03930	1.249e-72	248.0	COG1959@1|root,COG1959@2|Bacteria,1RB8I@1224|Proteobacteria,42WH7@68525|delta/epsilon subdivisions,2WSHY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS1_k127_1317831_3	641107.CDLVIII_2092	8.363e-35	136.0	COG3576@1|root,COG3576@2|Bacteria,1V3UU@1239|Firmicutes,25DNR@186801|Clostridia,36UDK@31979|Clostridiaceae	186801|Clostridia	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
MMS1_k127_1317831_1	1307761.L21SP2_0625	8.967e-110	362.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	azoB	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
MMS1_k127_1317831_5	1480694.DC28_12045	6.694e-16	80.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	rmaA	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_1321561_6	1341151.ASZU01000004_gene167	1.832e-14	76.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,4HJDZ@91061|Bacilli,27C6M@186824|Thermoactinomycetaceae	91061|Bacilli	S	SdpI/YhfL protein family	yvaZ	GO:0008150,GO:0009636,GO:0042221,GO:0050896	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
MMS1_k127_1321561_3	1341151.ASZU01000004_gene166	2.431e-27	113.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,4HKWM@91061|Bacilli,27CET@186824|Thermoactinomycetaceae	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	sdpR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS1_k127_1321561_2	744872.Spica_2826	8.283e-69	241.0	COG0566@1|root,COG0566@2|Bacteria,2J748@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
MMS1_k127_1321561_0	1499967.BAYZ01000122_gene3362	1.416e-224	709.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iYL1228.KPN_03016	HMGL-like,LeuA_dimer
MMS1_k127_1321561_1	1231241.Mc24_08724	3.682e-136	441.0	COG0473@1|root,COG0473@2|Bacteria,2GCZJ@200918|Thermotogae	200918|Thermotogae	H	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73	ko:K00052,ko:K07246	ko00290,ko00630,ko00650,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00630,map00650,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00215,R00994,R01751,R02545,R04426,R06180,R10052	RC00084,RC00105,RC00417,RC00594,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS1_k127_1321561_4	43989.cce_5145	1.642e-20	98.0	COG1848@1|root,COG1848@2|Bacteria,1G797@1117|Cyanobacteria,3KI68@43988|Cyanothece	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS1_k127_1324255_2	543526.Htur_0918	4.283e-16	85.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,23SKJ@183963|Halobacteria	183963|Halobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	hbd1	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS1_k127_1324255_3	1155714.KB891988_gene1659	1.642e-08	58.0	COG0236@1|root,COG0236@2|Bacteria,2IQ43@201174|Actinobacteria	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
MMS1_k127_1324255_0	246194.CHY_1355	6.731e-68	246.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,42EVW@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_1324255_1	646529.Desaci_2605	2.466e-33	142.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,26019@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_1325010_0	1128421.JAGA01000002_gene784	4.148e-143	465.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
MMS1_k127_1325010_3	1307761.L21SP2_0011	5.868e-42	157.0	COG0509@1|root,COG0509@2|Bacteria,2J8D7@203691|Spirochaetes	203691|Spirochaetes	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS1_k127_1325010_1	744872.Spica_2357	1.644e-106	356.0	COG0404@1|root,COG0404@2|Bacteria,2J6B1@203691|Spirochaetes	203691|Spirochaetes	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
MMS1_k127_1325010_2	443144.GM21_0880	7.426e-92	314.0	COG0642@1|root,COG2205@2|Bacteria,1R7QH@1224|Proteobacteria,42PSC@68525|delta/epsilon subdivisions,2WKFW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
MMS1_k127_1325010_4	869209.Tresu_2533	1.591e-25	110.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
MMS1_k127_1325976_8	204669.Acid345_4577	1.243e-06	56.0	COG1566@1|root,COG1566@2|Bacteria,3Y6U1@57723|Acidobacteria,2JKUF@204432|Acidobacteriia	204432|Acidobacteriia	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
MMS1_k127_1325976_5	1321778.HMPREF1982_02248	3.489e-24	110.0	COG1309@1|root,COG1309@2|Bacteria,1V3YX@1239|Firmicutes,24Q7E@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1325976_4	9913.ENSBTAP00000006933	9.446e-37	151.0	COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta,3BACQ@33208|Metazoa,3CSEJ@33213|Bilateria,481SB@7711|Chordata,495Q4@7742|Vertebrata,3J5ED@40674|Mammalia,4J08P@91561|Cetartiodactyla	33208|Metazoa	Q	retinol dehydrogenase 14	RDH14	GO:0001523,GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006066,GO:0006629,GO:0006720,GO:0006721,GO:0008106,GO:0008150,GO:0008152,GO:0009987,GO:0010817,GO:0012505,GO:0016020,GO:0016101,GO:0016491,GO:0016614,GO:0016616,GO:0031984,GO:0034308,GO:0034754,GO:0042175,GO:0042445,GO:0042572,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0052650,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0098827,GO:1901615	1.1.1.300,3.1.3.5	ko:K01081,ko:K11161,ko:K11162	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	adh_short
MMS1_k127_1325976_2	1112204.GPOL_c47830	3.516e-90	312.0	COG0438@1|root,COG0438@2|Bacteria,2I7GS@201174|Actinobacteria,4GG64@85026|Gordoniaceae	201174|Actinobacteria	M	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
MMS1_k127_1325976_0	1108045.GORHZ_075_00200	7.121e-132	434.0	COG5361@1|root,COG5361@2|Bacteria,2HES3@201174|Actinobacteria,4GH56@85026|Gordoniaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1214)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214
MMS1_k127_1325976_3	880070.Cycma_1547	3.471e-83	286.0	COG0702@1|root,COG0702@2|Bacteria,4NJCW@976|Bacteroidetes,47Q5P@768503|Cytophagia	976|Bacteroidetes	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
MMS1_k127_1325976_6	1123274.KB899414_gene3704	8.987e-23	105.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
MMS1_k127_1325976_1	439235.Dalk_3452	1.906e-90	308.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS1_k127_1325976_7	1123274.KB899420_gene4085	1.995e-22	97.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS1_k127_1327201_0	665571.STHERM_c10010	9.737e-193	608.0	COG0516@1|root,COG0516@2|Bacteria,2J5K7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
MMS1_k127_1327201_1	1307761.L21SP2_1842	1.674e-93	312.0	COG0519@1|root,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
MMS1_k127_1328807_0	1454004.AW11_00465	2.789e-12	80.0	COG2208@1|root,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,2VTSU@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	Sigma factor PP2C-like phosphatases	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,PAS_9,SpoIIE,cNMP_binding,dCache_1,dCache_2,sCache_2
MMS1_k127_1328875_4	522772.Dacet_0977	1.373e-82	284.0	COG0488@1|root,COG0488@2|Bacteria,2GF1Z@200930|Deferribacteres	200930|Deferribacteres	S	ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
MMS1_k127_1328875_8	573413.Spirs_2916	6.85e-43	173.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	7TMR-DISM_7TM,MCPsignal
MMS1_k127_1328875_0	1123274.KB899412_gene1471	3.725e-216	697.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J6N2@203691|Spirochaetes	203691|Spirochaetes	NT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
MMS1_k127_1328875_6	1307761.L21SP2_2540	2.315e-58	209.0	COG0835@1|root,COG0835@2|Bacteria,2J7NS@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_1328875_3	1123274.KB899412_gene1472	1.231e-83	286.0	COG1352@1|root,COG1352@2|Bacteria,2J7GX@203691|Spirochaetes	203691|Spirochaetes	NT	CheR methyltransferase, SAM binding domain	cheR-1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
MMS1_k127_1328875_1	1123274.KB899412_gene1473	2.1e-125	411.0	COG2201@1|root,COG2201@2|Bacteria	2|Bacteria	NT	protein-glutamate methylesterase activity	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1328875_7	1307761.L21SP2_2531	4.388e-52	188.0	COG1871@1|root,COG1871@2|Bacteria	2|Bacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
MMS1_k127_1328875_10	1307761.L21SP2_2530	4.522e-34	135.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	EAL,GAF_2,Hpt,PAS_9,Response_reg
MMS1_k127_1328875_5	665571.STHERM_c20940	1.941e-77	267.0	2EYA0@1|root,33RIG@2|Bacteria,2J6Q4@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1328875_2	573413.Spirs_2239	1.89e-96	319.0	COG0572@1|root,COG0572@2|Bacteria,2J6XC@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
MMS1_k127_1328875_9	717231.Flexsi_2211	3.998e-39	155.0	COG1434@1|root,COG1434@2|Bacteria,2GFV3@200930|Deferribacteres	200930|Deferribacteres	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
MMS1_k127_1328875_12	5722.XP_001315948.1	2.958e-13	74.0	COG0666@1|root,KOG4177@2759|Eukaryota	5722.XP_001315948.1|-	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1329673_0	1195236.CTER_1118	2.112e-265	839.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia	186801|Clostridia	G	hydrolase, family 65, central catalytic	-	-	2.4.1.8	ko:K00691	ko00500,ko01100,map00500,map01100	-	R01555	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
MMS1_k127_1329673_1	1227352.C173_29071	6.712e-30	128.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,4HCXP@91061|Bacilli,275ME@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.279	ko:K18783	-	-	R09941	RC00049	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
MMS1_k127_1330586_0	1304875.JAFZ01000002_gene288	1.317e-116	391.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,3TCA0@508458|Synergistetes	508458|Synergistetes	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LssY_C,PAP2,SNARE_assoc
MMS1_k127_1330586_4	572544.Ilyop_0776	2.657e-06	52.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
MMS1_k127_1330586_2	945713.IALB_3030	7.138e-37	143.0	COG3439@1|root,COG3439@2|Bacteria	2|Bacteria	D	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
MMS1_k127_1330586_3	1321815.HMPREF9193_00428	7.618e-11	68.0	COG5341@1|root,COG5341@2|Bacteria,2J8UX@203691|Spirochaetes	203691|Spirochaetes	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
MMS1_k127_1330586_1	868595.Desca_2408	1.131e-46	177.0	COG3212@1|root,COG3212@2|Bacteria,1VJGF@1239|Firmicutes,24RQ9@186801|Clostridia,262RI@186807|Peptococcaceae	186801|Clostridia	S	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1330586_5	479433.Caci_1777	0.0004742	44.0	COG0672@1|root,COG2822@1|root,COG0672@2|Bacteria,COG2822@2|Bacteria,2GJ22@201174|Actinobacteria	201174|Actinobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1,Peptidase_M75
MMS1_k127_1330664_2	1499683.CCFF01000017_gene2025	9.776e-57	207.0	COG0500@1|root,COG0500@2|Bacteria,1UZQD@1239|Firmicutes,24H3J@186801|Clostridia,36W61@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_1330664_0	1040982.AXAL01000002_gene5741	1.124e-147	474.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,43NWW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	NAD(P)H-binding	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
MMS1_k127_1330664_7	883114.HMPREF9709_01653	3.741e-25	108.0	COG1416@1|root,COG1416@2|Bacteria,1VEYT@1239|Firmicutes,24RMH@186801|Clostridia	186801|Clostridia	S	PFAM DsrE DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
MMS1_k127_1330664_6	857087.Metme_4453	5.066e-31	125.0	COG1708@1|root,COG1708@2|Bacteria,1NBM4@1224|Proteobacteria,1SCHR@1236|Gammaproteobacteria,1XFXB@135618|Methylococcales	135618|Methylococcales	L	PFAM Nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
MMS1_k127_1330664_3	867845.KI911784_gene2060	2.961e-44	165.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTase_sub_bind
MMS1_k127_1330664_1	1499683.CCFF01000014_gene4080	8.819e-91	312.0	COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,36EGS@31979|Clostridiaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMS1_k127_1330664_5	1211817.CCAT010000042_gene3246	2.704e-32	128.0	COG0454@1|root,COG0454@2|Bacteria,1V48Y@1239|Firmicutes,24HTW@186801|Clostridia,36IWS@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
MMS1_k127_1330664_4	573413.Spirs_1788	1.138e-40	154.0	COG1109@1|root,COG1109@2|Bacteria,2J5GY@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS1_k127_1331984_1	1308866.J416_10456	3.201e-33	136.0	COG1082@1|root,COG1082@2|Bacteria,1U81K@1239|Firmicutes,4HD3C@91061|Bacilli	91061|Bacilli	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMS1_k127_1331984_0	760011.Spico_0866	2.792e-215	689.0	COG4225@1|root,COG4225@2|Bacteria,2JA2C@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG4225 unsaturated glucuronyl hydrolase involved in regulation of surface properties and related protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
MMS1_k127_1334307_1	443143.GM18_1557	2.786e-32	147.0	COG3391@1|root,COG3637@1|root,COG4447@1|root,COG4886@1|root,COG3391@2|Bacteria,COG3637@2|Bacteria,COG4447@2|Bacteria,COG4886@2|Bacteria,1QXK5@1224|Proteobacteria	1224|Proteobacteria	M	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1334307_0	391598.FBBAL38_08809	1.678e-64	237.0	COG1470@1|root,COG2133@1|root,COG2304@1|root,COG2706@1|root,COG3209@1|root,COG3291@1|root,COG3420@1|root,COG4733@1|root,COG5279@1|root,COG1470@2|Bacteria,COG2133@2|Bacteria,COG2304@2|Bacteria,COG2706@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,COG5279@2|Bacteria,4P2UU@976|Bacteroidetes,1HYAX@117743|Flavobacteriia	976|Bacteroidetes	DZ	TIGRFAM Bacterial surface protein 26-residue repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Cadherin,DUF285,TIG,TSP_3
MMS1_k127_1337623_1	1307761.L21SP2_0399	4.522e-139	453.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1337623_2	491952.Mar181_0143	4.545e-35	142.0	COG1309@1|root,COG1309@2|Bacteria,1NMHE@1224|Proteobacteria	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1337623_0	1122919.KB905551_gene1751	7.627e-254	797.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli,26QA6@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1337751_2	1307761.L21SP2_3084	1.929e-125	421.0	COG0488@1|root,COG0488@2|Bacteria,2J5VJ@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0488 ATPase components of ABC transporter with duplicated ATPase domains	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
MMS1_k127_1337751_0	1123274.KB899408_gene3795	1.08e-264	826.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,2J6JA@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	1.12.1.3,1.17.99.7,1.6.5.3	ko:K00336,ko:K18332,ko:K22015	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS1_k127_1337751_1	1123274.KB899408_gene3796	5.476e-253	792.0	COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,2J5W1@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
MMS1_k127_1338280_0	1541960.KQ78_00626	2.753e-95	329.0	COG4753@1|root,COG4753@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
MMS1_k127_1338280_1	1122947.FR7_0896	2.84e-30	124.0	COG2221@1|root,COG2221@2|Bacteria,1VBGQ@1239|Firmicutes,4H8VA@909932|Negativicutes	909932|Negativicutes	C	TIGRFAM C_GCAxxG_C_C family protein	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
MMS1_k127_1338280_3	945713.IALB_2487	1.788e-28	124.0	COG2091@1|root,COG2091@2|Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	hetI	-	2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
MMS1_k127_1338280_2	1007103.AFHW01000010_gene6064	4.85e-30	130.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HCH3@91061|Bacilli,26VPR@186822|Paenibacillaceae	91061|Bacilli	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS1_k127_1340515_3	906968.Trebr_0582	4.048e-12	67.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1340515_2	545694.TREPR_0664	3.576e-16	89.0	290XW@1|root,2ZNJN@2|Bacteria,2J6SW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1340515_1	545694.TREPR_3510	6.196e-43	166.0	COG5497@1|root,COG5497@2|Bacteria,2J7E8@203691|Spirochaetes	203691|Spirochaetes	S	Predicted secreted protein (DUF2259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2259
MMS1_k127_1340515_0	443143.GM18_2774	6.956e-205	653.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,43TSA@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
MMS1_k127_134314_0	1265505.ATUG01000001_gene4653	1.779e-82	299.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_134314_1	545694.TREPR_0550	2.75e-41	169.0	2DH0R@1|root,2ZXZV@2|Bacteria,2JBJ7@203691|Spirochaetes	203691|Spirochaetes	S	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS1_k127_1345787_4	1123274.KB899414_gene3736	1.401e-16	87.0	2ADW4@1|root,32XTR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
MMS1_k127_1345787_1	1307761.L21SP2_1401	1.176e-91	310.0	COG1092@1|root,COG1092@2|Bacteria,2J5I4@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.191,2.1.1.264	ko:K06969,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
MMS1_k127_1345787_0	1408424.JHYI01000003_gene3928	2.852e-125	414.0	COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,4HCBS@91061|Bacilli,1ZQ31@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	msmE	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_1347296_4	1219031.BBJR01000028_gene158	5.188e-05	48.0	COG1280@1|root,COG1280@2|Bacteria,1RET0@1224|Proteobacteria,2WFM1@28216|Betaproteobacteria,4AJC7@80864|Comamonadaceae	28216|Betaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
MMS1_k127_1347296_0	324057.Pjdr2_4197	2.1e-134	434.0	2C4GI@1|root,33S07@2|Bacteria,1VU4E@1239|Firmicutes,4HU5Q@91061|Bacilli,26U64@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1861)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1861
MMS1_k127_1347296_2	1480694.DC28_15105	1.651e-111	366.0	COG0395@1|root,COG0395@2|Bacteria,2J64K@203691|Spirochaetes	2|Bacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1347296_1	1480694.DC28_15110	8.433e-120	395.0	COG1175@1|root,COG1175@2|Bacteria,2J5N6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17245	ko02010,map02010	M00601	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.40	-	-	-
MMS1_k127_1347296_3	1480694.DC28_15115	4.758e-16	79.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
MMS1_k127_1347638_0	658187.LDG_6875	5.48e-110	368.0	COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,1RY7N@1236|Gammaproteobacteria,1JFUN@118969|Legionellales	118969|Legionellales	S	FIST_C	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
MMS1_k127_1347638_1	395494.Galf_1869	6.205e-67	241.0	COG0715@1|root,COG0834@1|root,COG2199@1|root,COG3290@1|root,COG0715@2|Bacteria,COG0834@2|Bacteria,COG2199@2|Bacteria,COG3290@2|Bacteria,1RGCV@1224|Proteobacteria,2VK9Q@28216|Betaproteobacteria,44WPJ@713636|Nitrosomonadales	28216|Betaproteobacteria	T	SMART GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,PAS_9,SnoaL_3
MMS1_k127_1348138_2	1449063.JMLS01000004_gene2751	7.774e-05	45.0	COG1879@1|root,COG1879@2|Bacteria,1TPWA@1239|Firmicutes,4IPVE@91061|Bacilli,2764Q@186822|Paenibacillaceae	91061|Bacilli	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1348138_1	771875.Ferpe_1842	8.5e-16	89.0	COG1609@1|root,COG1609@2|Bacteria,2GC06@200918|Thermotogae	200918|Thermotogae	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1348138_0	926550.CLDAP_17920	9.058e-38	143.0	COG0656@1|root,COG0656@2|Bacteria,2G6NH@200795|Chloroflexi	200795|Chloroflexi	S	Aldo/keto reductase family	-	-	1.1.1.2	ko:K00002	ko00010,ko00040,ko00561,ko00930,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00561,map00930,map01100,map01110,map01120,map01130,map01220	M00014	R00746,R01041,R01481,R05231	RC00087,RC00088,RC00099,RC00108	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Aldo_ket_red
MMS1_k127_1349766_0	321332.CYB_0250	2.495e-119	395.0	COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria,1GZ02@1129|Synechococcus	1117|Cyanobacteria	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
MMS1_k127_1349766_1	1321779.HMPREF1984_00013	5.71e-44	170.0	COG0561@1|root,COG0561@2|Bacteria,378IE@32066|Fusobacteria	32066|Fusobacteria	S	Cof-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
MMS1_k127_1350759_1	1197906.CAJQ02000011_gene621	6.97e-09	68.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TV9W@28211|Alphaproteobacteria,3JWYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
MMS1_k127_1350759_0	984262.SGRA_3671	2.533e-53	199.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IQYT@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_1352835_0	765420.OSCT_2131	4.82e-233	735.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	tanA	-	-	-	-	-	-	-	-	-	-	-	COesterase,Esterase,Peptidase_S9
MMS1_k127_1352835_1	1128111.HMPREF0870_01326	8.589e-55	199.0	COG4099@1|root,COG4099@2|Bacteria,1V3AJ@1239|Firmicutes,4H24G@909932|Negativicutes	909932|Negativicutes	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Sel1
MMS1_k127_1352835_2	1280706.AUJE01000028_gene1446	7.226e-09	61.0	COG0790@1|root,COG4099@1|root,COG0790@2|Bacteria,COG4099@2|Bacteria,1V3AJ@1239|Firmicutes,4H24G@909932|Negativicutes	909932|Negativicutes	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Sel1
MMS1_k127_1353687_0	573413.Spirs_0213	3.725e-264	822.0	COG0696@1|root,COG0696@2|Bacteria,2J5QJ@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,iPGM_N
MMS1_k127_1353687_1	1123274.KB899407_gene222	6.057e-06	49.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
MMS1_k127_1356489_3	293826.Amet_4278	6.905e-31	127.0	COG1051@1|root,COG1051@2|Bacteria,1V7HB@1239|Firmicutes,25EBY@186801|Clostridia,36UJV@31979|Clostridiaceae	186801|Clostridia	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
MMS1_k127_1356489_4	1007096.BAGW01000018_gene744	1.123e-09	61.0	COG4333@1|root,COG4333@2|Bacteria,1V8CT@1239|Firmicutes,24K6U@186801|Clostridia,2N71V@216572|Oscillospiraceae	186801|Clostridia	S	Protein of unknown function (DUF1643)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1643
MMS1_k127_1356489_2	1121930.AQXG01000006_gene774	9.148e-33	130.0	COG4333@1|root,COG4333@2|Bacteria,4NW3C@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1643)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1643
MMS1_k127_1356489_1	526222.Desal_2279	1.337e-35	147.0	COG0834@1|root,COG0834@2|Bacteria,1MZ9S@1224|Proteobacteria,42TJX@68525|delta/epsilon subdivisions,2WR4Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_1356489_0	1408473.JHXO01000011_gene3002	4.024e-48	179.0	COG0546@1|root,COG0546@2|Bacteria,4NRB4@976|Bacteroidetes,2FTCK@200643|Bacteroidia	976|Bacteroidetes	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_1357080_3	1218103.CIN01S_01_00630	2.297e-17	83.0	COG3129@1|root,COG3129@2|Bacteria,4NF3Z@976|Bacteroidetes,1HWRU@117743|Flavobacteriia,3ZNQX@59732|Chryseobacterium	976|Bacteroidetes	J	Specifically methylates the adenine in position 1618 of 23S rRNA	rlmF	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052907,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.181	ko:K06970	-	-	R07232	RC00003,RC00335	ko00000,ko01000,ko03009	-	-	-	Methyltransf_10
MMS1_k127_1357080_5	1090320.KB900605_gene3383	7.601e-05	50.0	COG1983@1|root,COG1983@2|Bacteria,1RHXA@1224|Proteobacteria,2UA9Z@28211|Alphaproteobacteria,2K54F@204457|Sphingomonadales	204457|Sphingomonadales	KT	PspC domain	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
MMS1_k127_1357080_2	1250232.JQNJ01000001_gene348	3.357e-29	132.0	COG0627@1|root,COG0627@2|Bacteria,4NIU8@976|Bacteroidetes,1I1H5@117743|Flavobacteriia	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
MMS1_k127_1357080_4	1123326.JFBL01000006_gene950	6.484e-05	54.0	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42U0X@68525|delta/epsilon subdivisions,2YPSD@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Transcriptional regulator	arsR	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
MMS1_k127_1357080_1	1403313.AXBR01000009_gene842	2.891e-49	184.0	COG0454@1|root,COG0456@2|Bacteria,1V37I@1239|Firmicutes,4HGJH@91061|Bacilli,1ZIKD@1386|Bacillus	91061|Bacilli	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_1357080_0	338963.Pcar_1336	4.536e-116	400.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42PCY@68525|delta/epsilon subdivisions,2WJCR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Chemotaxis sensory transducer	-	-	-	ko:K03406,ko:K13487	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Cache_3-Cache_2,HAMP,MCPsignal
MMS1_k127_1360227_0	221027.JO40_06550	4.229e-58	220.0	2DPMC@1|root,332N2@2|Bacteria,2J7ED@203691|Spirochaetes	203691|Spirochaetes	S	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,fn3
MMS1_k127_1361545_0	867845.KI911784_gene693	6.83e-161	515.0	COG4214@1|root,COG4214@2|Bacteria,2G8H9@200795|Chloroflexi,376ZS@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
MMS1_k127_1361545_1	1031288.AXAA01000003_gene1730	6.358e-20	90.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
MMS1_k127_136685_1	1226325.HMPREF1548_03012	7.063e-66	237.0	COG2972@1|root,COG2972@2|Bacteria,1UW4A@1239|Firmicutes,24ZJ7@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
MMS1_k127_136685_0	1226325.HMPREF1548_03013	6.529e-95	330.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,36DSG@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_1367131_0	573413.Spirs_2414	8.295e-114	370.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2J5C7@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Asn_synthase,GATase,GMP_synt_C,NAD_synthase
MMS1_k127_1367131_1	1235792.C808_04540	3.468e-38	150.0	COG0395@1|root,COG0395@2|Bacteria,1TQTW@1239|Firmicutes,2485X@186801|Clostridia,27NEQ@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1367366_2	665571.STHERM_c13090	9.23e-87	293.0	COG0020@1|root,COG0020@2|Bacteria,2J5Y6@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
MMS1_k127_1367366_4	1124982.MSI_19630	9.108e-45	173.0	COG0575@1|root,COG0575@2|Bacteria,2JBF6@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
MMS1_k127_1367366_1	744872.Spica_1420	4.354e-112	373.0	COG0743@1|root,COG0743@2|Bacteria,2J5M4@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
MMS1_k127_1367366_0	744872.Spica_1421	4.116e-129	426.0	COG0750@1|root,COG0750@2|Bacteria,2J616@203691|Spirochaetes	203691|Spirochaetes	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
MMS1_k127_1367366_3	573413.Spirs_2872	8.22e-57	221.0	COG2319@1|root,COG2319@2|Bacteria,2JBCI@203691|Spirochaetes	203691|Spirochaetes	S	WD40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1369823_4	572544.Ilyop_0397	3.741e-26	108.0	COG1004@1|root,COG1004@2|Bacteria,379NW@32066|Fusobacteria	32066|Fusobacteria	C	Psort location Cytoplasmic, score	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
MMS1_k127_1369823_1	1121865.OMW_00925	5.946e-140	449.0	COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,4H9R0@91061|Bacilli,4B0GS@81852|Enterococcaceae	91061|Bacilli	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS1_k127_1369823_3	1480694.DC28_12780	2.904e-73	252.0	COG1898@1|root,COG1898@2|Bacteria,2J65Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
MMS1_k127_1369823_2	573413.Spirs_0681	6.802e-108	358.0	COG1091@1|root,COG1091@2|Bacteria,2J5U8@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
MMS1_k127_1369823_0	744872.Spica_1328	3.177e-171	546.0	COG1088@1|root,COG1088@2|Bacteria,2J5ND@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
MMS1_k127_1369823_5	459349.CLOAM0646	4.753e-13	72.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	-	-	1.14.12.17	ko:K02639,ko:K05916	ko00195,ko05132,map00195,map05132	-	-	-	ko00000,ko00001,ko00194,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
MMS1_k127_1374285_0	1123274.KB899412_gene1535	2.167e-248	777.0	COG1061@1|root,COG1061@2|Bacteria,2J6EB@203691|Spirochaetes	203691|Spirochaetes	L	DNA or RNA helicase of superfamily II	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
MMS1_k127_1374285_1	1123274.KB899412_gene1534	2.012e-46	184.0	2F2R9@1|root,33VMJ@2|Bacteria,2J5DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
MMS1_k127_1374422_0	1307761.L21SP2_0391	3.422e-194	627.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1376255_1	1410630.JNKP01000005_gene662	3.484e-89	300.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,27IU7@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Class II Aldolase and Adducin N-terminal domain	araD	-	5.1.3.4	ko:K03077	ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120	M00550	R05850	RC01479	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
MMS1_k127_1376255_0	1123277.KB893195_gene5699	1.351e-216	681.0	COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,47J96@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the conversion of L-arabinose to L-ribulose	araA	-	5.3.1.4	ko:K01804	ko00040,ko01100,map00040,map01100	-	R01761	RC00516	ko00000,ko00001,ko01000	-	-	-	Arabinose_Iso_C,Arabinose_Isome
MMS1_k127_1376255_2	748449.Halha_1744	4.254e-68	244.0	COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,24ARJ@186801|Clostridia,3WBV1@53433|Halanaerobiales	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
MMS1_k127_1376255_3	1131462.DCF50_p1459	5.241e-52	199.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,265FD@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	2.7.7.65	ko:K02488,ko:K18967,ko:K21022	ko02020,ko02025,ko04112,map02020,map02025,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02022	9.B.34.1.1	-	-	GGDEF,PAS_9
MMS1_k127_1376255_5	926561.KB900623_gene863	3.426e-14	80.0	COG1309@1|root,COG1309@2|Bacteria,1VKSB@1239|Firmicutes,24UVW@186801|Clostridia,3WC4E@53433|Halanaerobiales	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1376255_4	1123035.ARLA01000028_gene2608	9.945e-31	138.0	COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia,4C3KZ@83612|Psychroflexus	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
MMS1_k127_1380637_0	1122621.ATZA01000029_gene2744	7.907e-131	423.0	COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,1IP4A@117747|Sphingobacteriia	976|Bacteroidetes	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_1380637_2	1195236.CTER_1899	7.559e-26	114.0	COG1309@1|root,COG1309@2|Bacteria,1U9UE@1239|Firmicutes,24F64@186801|Clostridia,3WKXU@541000|Ruminococcaceae	186801|Clostridia	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
MMS1_k127_1380637_1	1230342.CTM_11765	4.192e-52	190.0	COG0431@1|root,COG0655@1|root,COG0431@2|Bacteria,COG0655@2|Bacteria,1UYCI@1239|Firmicutes,24DA4@186801|Clostridia,36G6H@31979|Clostridiaceae	186801|Clostridia	S	COG0655 Multimeric flavodoxin WrbA	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
MMS1_k127_1382205_11	1128398.Curi_c29360	0.0005671	49.0	COG1633@1|root,COG1633@2|Bacteria,1VAB8@1239|Firmicutes,24SM6@186801|Clostridia,26BPH@186813|unclassified Clostridiales	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS1_k127_1382205_10	1394176.AWUO01000001_gene1412	7.549e-05	48.0	COG0355@1|root,COG0355@2|Bacteria,2HZPJ@201174|Actinobacteria,4D16F@85004|Bifidobacteriales	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
MMS1_k127_1382205_1	986075.CathTA2_2807	6.437e-213	670.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,4HAT6@91061|Bacilli	91061|Bacilli	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSB619.SA_RS10965	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_1382205_4	706587.Desti_3706	5.697e-39	156.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MQDF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
MMS1_k127_1382205_2	414684.RC1_2243	3.699e-185	602.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2JQN1@204441|Rhodospirillales	204441|Rhodospirillales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
MMS1_k127_1382205_9	568703.LGG_01180	3.22e-11	70.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,4HKFW@91061|Bacilli,3F5TZ@33958|Lactobacillaceae	91061|Bacilli	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
MMS1_k127_1382205_8	880073.Calab_0235	1.444e-14	79.0	COG0711@1|root,COG0711@2|Bacteria,2NPWH@2323|unclassified Bacteria	2|Bacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
MMS1_k127_1382205_7	626522.GCWU000325_01107	3.247e-16	80.0	COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,2FTSZ@200643|Bacteroidia,1WDJI@1283313|Alloprevotella	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
MMS1_k127_1382205_5	880073.Calab_0237	2.288e-37	151.0	COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
MMS1_k127_1382205_6	158189.SpiBuddy_2012	1.559e-33	142.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Beta_helix,Big_2,DUF3494,W_rich_C
MMS1_k127_1382205_3	1123274.KB899422_gene107	2.9e-57	208.0	COG0565@1|root,COG0565@2|Bacteria,2J6NV@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
MMS1_k127_1382205_0	525897.Dbac_3209	7.595e-319	994.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,2M8WP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	iAF987.Gmet_3512	Aldedh,Pro_dh
MMS1_k127_1385326_1	1385935.N836_04355	4.079e-42	166.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
MMS1_k127_1385326_0	1279015.KB908468_gene411	2.505e-128	424.0	COG1119@1|root,COG1119@2|Bacteria,1MVVM@1224|Proteobacteria,1RMXK@1236|Gammaproteobacteria,1Y54G@135624|Aeromonadales	135624|Aeromonadales	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K05776	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	ABC_tran
MMS1_k127_1385326_2	1245471.PCA10_56190	1.69e-29	128.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RX6D@1236|Gammaproteobacteria,1YIHE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
MMS1_k127_1389475_0	573413.Spirs_1944	4.983e-63	227.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD,HAD_2,Hydrolase,Hydrolase_like
MMS1_k127_1389475_1	665571.STHERM_c10720	2.474e-37	147.0	2FG0B@1|root,347X1@2|Bacteria,2J8HA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1389801_0	1429046.RR21198_1603	8.664e-160	542.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4FVN8@85025|Nocardiaceae	201174|Actinobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
MMS1_k127_1391175_1	877418.ATWV01000001_gene1563	3.962e-49	179.0	COG0756@1|root,COG0756@2|Bacteria,2J7JH@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
MMS1_k127_1391175_0	889378.Spiaf_1535	4.025e-182	578.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
MMS1_k127_1392742_4	1232447.BAHW02000024_gene1608	1.1e-11	67.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,268WP@186813|unclassified Clostridiales	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS1_k127_1392742_1	264732.Moth_1706	8.761e-123	400.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS1_k127_1392742_0	1385935.N836_25065	1.52e-195	619.0	COG2873@1|root,COG2873@2|Bacteria,1G4EH@1117|Cyanobacteria,1H9KG@1150|Oscillatoriales	1117|Cyanobacteria	E	Cys/Met metabolism PLP-dependent enzyme	met17	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
MMS1_k127_1392742_5	401526.TcarDRAFT_0501	5.658e-10	64.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,4H5BR@909932|Negativicutes	909932|Negativicutes	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
MMS1_k127_1392742_3	744872.Spica_1851	1.902e-54	214.0	COG2208@1|root,COG2208@2|Bacteria,2JAMR@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
MMS1_k127_1392742_6	56110.Oscil6304_2557	8.544e-05	47.0	COG2172@1|root,COG2172@2|Bacteria,1G5Z9@1117|Cyanobacteria,1HAVW@1150|Oscillatoriales	1117|Cyanobacteria	T	Anti-Sigma regulatory factor (Ser Thr protein kinase)	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
MMS1_k127_1392742_2	391009.Tmel_1637	2.487e-86	296.0	COG3568@1|root,COG3568@2|Bacteria,2GDR7@200918|Thermotogae	200918|Thermotogae	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1393796_0	186497.PF0729	1.216e-46	183.0	COG1145@1|root,COG1456@1|root,arCOG00958@2157|Archaea,arCOG06909@2157|Archaea	2157|Archaea	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,Fer4,PAPS_reduct
MMS1_k127_1394594_4	63737.Npun_R2272	4.935e-09	59.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1HJ09@1161|Nostocales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,PAS_3,PAS_4,Pkinase
MMS1_k127_1394594_3	994573.T472_0209175	9.735e-51	186.0	COG0348@1|root,COG0348@2|Bacteria,1UHUA@1239|Firmicutes	1239|Firmicutes	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
MMS1_k127_1394594_2	1307761.L21SP2_3409	1.819e-71	248.0	COG1762@1|root,COG1762@2|Bacteria,2J5KE@203691|Spirochaetes	203691|Spirochaetes	G	DNA-binding protein PTS system, IIA component	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
MMS1_k127_1394594_0	240015.ACP_3079	2.84e-102	342.0	COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria,2JKXN@204432|Acidobacteriia	204432|Acidobacteriia	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
MMS1_k127_1394594_1	1343739.PAP_03295	4.194e-75	263.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y246@28890|Euryarchaeota,244HM@183968|Thermococci	183968|Thermococci	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7
MMS1_k127_1394594_5	572544.Ilyop_1582	1.737e-08	55.0	COG1053@1|root,COG1053@2|Bacteria,379QD@32066|Fusobacteria	32066|Fusobacteria	C	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FMN_bind
MMS1_k127_1400171_1	760011.Spico_0097	1.619e-86	298.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1400171_0	760011.Spico_0098	3.652e-207	655.0	COG1129@1|root,COG1129@2|Bacteria	2|Bacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1400171_2	760011.Spico_0099	1.179e-36	146.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_1400988_0	1469948.JPNB01000002_gene3602	1.05e-210	666.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1400988_1	760011.Spico_1628	5.168e-125	409.0	COG1172@1|root,COG1172@2|Bacteria,2J5WZ@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_1400988_2	1195236.CTER_1319	7.237e-36	141.0	COG1879@1|root,COG1879@2|Bacteria,1TQ95@1239|Firmicutes,24AX7@186801|Clostridia,3WMWE@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1405287_0	1307761.L21SP2_3301	3.499e-232	728.0	COG0504@1|root,COG0504@2|Bacteria,2J5AB@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMS1_k127_140632_2	324925.Ppha_2513	3.991e-10	60.0	arCOG06916@1|root,30456@2|Bacteria,1FF5T@1090|Chlorobi	1090|Chlorobi	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
MMS1_k127_140632_1	203119.Cthe_2991	4.873e-30	126.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3WJYC@541000|Ruminococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	enr	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
MMS1_k127_1406779_1	760568.Desku_2912	1.547e-17	87.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,262BX@186807|Peptococcaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
MMS1_k127_1406779_0	1123274.KB899422_gene70	9.06e-219	689.0	COG1022@1|root,COG1022@2|Bacteria,2J65F@203691|Spirochaetes	203691|Spirochaetes	I	Long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
MMS1_k127_1406985_4	96561.Dole_1771	8.349e-06	55.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMS1_k127_1406985_3	177437.HRM2_02050	1.4e-21	102.0	2B831@1|root,321AX@2|Bacteria,1RIGM@1224|Proteobacteria,42WHA@68525|delta/epsilon subdivisions,2WSHZ@28221|Deltaproteobacteria,2MKZH@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1406985_0	177437.HRM2_02030	2.034e-115	391.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2MISX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS1_k127_1406985_1	1499967.BAYZ01000013_gene6425	5.377e-81	276.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	2.7.1.15,4.1.2.4	ko:K00852,ko:K01619	ko00030,map00030	-	R01051,R01066,R02750	RC00002,RC00017,RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
MMS1_k127_1406985_2	313628.LNTAR_21300	2.456e-69	243.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1407396_2	760011.Spico_0151	1.87e-40	155.0	2CMS6@1|root,339SN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
MMS1_k127_1407396_0	180332.JTGN01000001_gene5320	2.505e-83	297.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TV2J@1239|Firmicutes,249HW@186801|Clostridia	186801|Clostridia	T	Response regulator receiver domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_1407396_1	697281.Mahau_2734	5.253e-72	255.0	COG2972@1|root,COG2972@2|Bacteria,1TRKI@1239|Firmicutes,24B7C@186801|Clostridia,42HV9@68295|Thermoanaerobacterales	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
MMS1_k127_1407396_3	1209989.TepiRe1_0522	3.496e-30	130.0	COG1129@1|root,COG1129@2|Bacteria,1TR82@1239|Firmicutes,24AFZ@186801|Clostridia,42I00@68295|Thermoanaerobacterales	186801|Clostridia	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1412033_0	1250232.JQNJ01000001_gene2135	4.894e-165	524.0	COG1064@1|root,COG1064@2|Bacteria,4NTXE@976|Bacteroidetes,1IJWX@117743|Flavobacteriia	976|Bacteroidetes	S	Alanine dehydrogenase/PNT, C-terminal domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_1412033_1	1206101.AZXC01000019_gene1469	6.204e-27	116.0	2DM8J@1|root,32695@2|Bacteria,2I561@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1412033_2	1123263.AUKY01000062_gene2321	8.56e-14	73.0	COG2045@1|root,COG2045@2|Bacteria,1V56I@1239|Firmicutes,3VQIF@526524|Erysipelotrichia	526524|Erysipelotrichia	H	2-phosphosulpholactate phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	2-ph_phosp
MMS1_k127_1412123_0	744872.Spica_1633	1.049e-104	347.0	COG1181@1|root,COG1181@2|Bacteria,2J5KK@203691|Spirochaetes	203691|Spirochaetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4
MMS1_k127_1412123_3	1124982.MSI_20060	3.428e-45	168.0	COG0500@1|root,COG1861@1|root,COG0500@2|Bacteria,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
MMS1_k127_1412123_4	1123274.KB899412_gene1456	3.844e-43	173.0	COG2227@1|root,COG2227@2|Bacteria,2JBIU@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase domain	ubiG	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS1_k127_1412123_2	1123274.KB899412_gene1455	3.543e-56	207.0	COG1861@1|root,COG1861@2|Bacteria,2J58C@203691|Spirochaetes	203691|Spirochaetes	M	spore coat polysaccharide biosynthesis protein	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3,Methyltransf_23
MMS1_k127_1412123_1	1123274.KB899412_gene1454	1.721e-91	311.0	COG1216@1|root,COG1216@2|Bacteria,2J6ET@203691|Spirochaetes	203691|Spirochaetes	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1412534_0	889378.Spiaf_0914	5.511e-297	928.0	28HY3@1|root,2Z83I@2|Bacteria	2|Bacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
MMS1_k127_1421181_1	1408473.JHXO01000007_gene899	3.47e-140	459.0	COG0527@1|root,COG0527@2|Bacteria,4PKFA@976|Bacteroidetes,2G3F2@200643|Bacteroidia	976|Bacteroidetes	E	Amino acid kinase family	-	-	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
MMS1_k127_1421181_3	1499683.CCFF01000013_gene352	3.668e-47	179.0	COG1011@1|root,COG1011@2|Bacteria,1TRQ6@1239|Firmicutes,25B04@186801|Clostridia,36WB0@31979|Clostridiaceae	186801|Clostridia	S	HAD superfamily (Subfamily IA) hydrolase, TIGR02254	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_1421181_2	1123278.KB893488_gene6087	1.038e-54	200.0	COG2135@1|root,COG2135@2|Bacteria,4NI3T@976|Bacteroidetes,47XPZ@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the SOS response-associated peptidase family	yoqW	-	-	-	-	-	-	-	-	-	-	-	SRAP
MMS1_k127_1421181_0	1125863.JAFN01000001_gene2492	2.877e-190	602.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2WJMT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3169	PEPCK_ATP
MMS1_k127_1425827_0	102129.Lepto7375DRAFT_5463	8.794e-142	471.0	28MJK@1|root,2ZAW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1425827_1	588596.U9U9X2	1.494e-29	132.0	COG0790@1|root,KOG1550@2759|Eukaryota,38DA9@33154|Opisthokonta	33154|Opisthokonta	MOT	fungal-type cell wall polysaccharide biosynthetic process	CHS4	GO:0000003,GO:0000131,GO:0000271,GO:0003006,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005628,GO:0005933,GO:0005935,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006030,GO:0006031,GO:0006037,GO:0006038,GO:0006040,GO:0006807,GO:0007049,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009272,GO:0009653,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0017144,GO:0019953,GO:0022402,GO:0022413,GO:0022414,GO:0030154,GO:0030234,GO:0030427,GO:0030435,GO:0030437,GO:0032502,GO:0032505,GO:0033692,GO:0034221,GO:0034293,GO:0034637,GO:0034645,GO:0042546,GO:0042763,GO:0042764,GO:0043085,GO:0043170,GO:0043934,GO:0043935,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044464,GO:0044703,GO:0046349,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0050790,GO:0051278,GO:0051321,GO:0051704,GO:0065007,GO:0065009,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:0071966,GO:0098772,GO:1901071,GO:1901073,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903046	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
MMS1_k127_1425827_2	1173027.Mic7113_2673	2.333e-09	64.0	COG2114@1|root,COG2202@1|root,COG3437@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,1GQRR@1117|Cyanobacteria,1H9GQ@1150|Oscillatoriales	1117|Cyanobacteria	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,PAS_9,Response_reg
MMS1_k127_1425881_3	1122927.KB895418_gene2866	4.809e-13	71.0	COG1011@1|root,COG1011@2|Bacteria,1V3M1@1239|Firmicutes,4IUEQ@91061|Bacilli,26XHU@186822|Paenibacillaceae	91061|Bacilli	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMS1_k127_1425881_2	1123274.KB899410_gene3412	4.446e-31	125.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	ytfH	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS1_k127_1425881_0	573413.Spirs_3881	3.638e-83	285.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	ytfG	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.6.5.2	ko:K19267	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10,NmrA
MMS1_k127_1425881_1	1125701.HMPREF1221_01361	8.212e-36	144.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
MMS1_k127_14290_0	573061.Clocel_3640	1.223e-193	612.0	COG1501@1|root,COG1501@2|Bacteria,1UJ1V@1239|Firmicutes,24AVU@186801|Clostridia,36HI8@31979|Clostridiaceae	186801|Clostridia	G	Alpha galactosidase A	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase_2
MMS1_k127_14290_4	573413.Spirs_4284	1.353e-35	142.0	COG0140@1|root,COG0140@2|Bacteria	2|Bacteria	E	phosphoribosyl-ATP diphosphatase activity	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.6.1.31,5.3.1.16	ko:K01523,ko:K01814,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04640	RC00002,RC00945,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860	PRA-CH,PRA-PH
MMS1_k127_14290_2	59374.Fisuc_1150	1.385e-107	358.0	COG0418@1|root,COG0418@2|Bacteria	2|Bacteria	F	dihydroorotase activity	pyrC	GO:0003674,GO:0003824,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS1_k127_14290_3	46234.ANA_C20394	1.397e-65	236.0	COG0515@1|root,COG5263@1|root,COG0515@2|Bacteria,COG5263@2|Bacteria,1G1AI@1117|Cyanobacteria,1HKZW@1161|Nostocales	1117|Cyanobacteria	KLT	PFAM KWG Leptospira	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
MMS1_k127_14290_1	1480694.DC28_09125	3.691e-188	602.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
MMS1_k127_1429209_4	889378.Spiaf_2061	4.786e-71	260.0	COG2206@1|root,COG2206@2|Bacteria,2JAC9@203691|Spirochaetes	203691|Spirochaetes	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1429209_1	598467.BrE312_2859	9.526e-181	569.0	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,1S1RV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	3.7.1.18	ko:K20765	-	-	-	-	ko00000,ko01000	-	-	-	ECH_1
MMS1_k127_1429209_5	1042156.CXIVA_02310	2.065e-49	188.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24HPS@186801|Clostridia,36KGZ@31979|Clostridiaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1429209_2	768710.DesyoDRAFT_1780	5.165e-155	512.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260JR@186807|Peptococcaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
MMS1_k127_1429209_3	1461579.CCNK01000039_gene1856	6.757e-80	273.0	COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,1S3TR@1236|Gammaproteobacteria,1YAUC@135625|Pasteurellales	135625|Pasteurellales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS1_k127_1429209_0	1461579.CCNK01000039_gene1854	7.407e-183	575.0	COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,1S1RV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	3.7.1.18	ko:K20765	-	-	-	-	ko00000,ko01000	-	-	-	ECH_1
MMS1_k127_1429209_6	1117319.PSPO_19436	0.0009127	49.0	COG0840@1|root,COG0840@2|Bacteria,1NS95@1224|Proteobacteria,1SJJS@1236|Gammaproteobacteria,2Q410@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	NT	Nitrate and nitrite sensing	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,NIT
MMS1_k127_1430226_4	640511.BC1002_1052	1.931e-09	60.0	COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,2VJWG@28216|Betaproteobacteria,1K0M8@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_1430226_2	105425.BBPL01000014_gene2744	3.094e-59	216.0	COG0583@1|root,COG0583@2|Bacteria,2GMDN@201174|Actinobacteria,2NGMX@228398|Streptacidiphilus	201174|Actinobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1430226_3	573413.Spirs_1962	3.612e-46	170.0	COG3328@1|root,COG3328@2|Bacteria,2J57X@203691|Spirochaetes	203691|Spirochaetes	L	PFAM Transposase, Mutator family	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
MMS1_k127_1430226_0	573413.Spirs_4305	0.0	1062.0	COG0188@1|root,COG0188@2|Bacteria,2J5NK@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS1_k127_1430226_1	744872.Spica_2869	2.712e-96	318.0	COG0187@1|root,COG0187@2|Bacteria,2J67M@203691|Spirochaetes	203691|Spirochaetes	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS1_k127_1430532_5	476272.RUMHYD_03634	5.841e-08	56.0	2DVG6@1|root,33VR8@2|Bacteria,1VWC9@1239|Firmicutes,2510P@186801|Clostridia,3Y1S5@572511|Blautia	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_1430532_2	589865.DaAHT2_0317	6.802e-48	177.0	29WJN@1|root,30I61@2|Bacteria,1NR09@1224|Proteobacteria,42ZE7@68525|delta/epsilon subdivisions,2WURB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1430532_3	931276.Cspa_c31440	6.824e-40	158.0	COG1145@1|root,COG1145@2|Bacteria,1UI80@1239|Firmicutes,25ED6@186801|Clostridia,36UKW@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9,Flavodoxin_5
MMS1_k127_1430532_4	1185876.BN8_00568	2.519e-14	81.0	COG1309@1|root,COG1309@2|Bacteria,4NNNT@976|Bacteroidetes,47SG0@768503|Cytophagia	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1430532_0	658088.HMPREF0987_02568	1.049e-311	971.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,27J28@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolase family 3 C-terminal domain	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1430532_1	1414720.CBYM010000014_gene2773	2.229e-115	374.0	COG4608@1|root,COG4608@2|Bacteria,1V0JP@1239|Firmicutes,24DNW@186801|Clostridia,36QK6@31979|Clostridiaceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS1_k127_1434273_5	545694.TREPR_2564	4.206e-26	109.0	COG4974@1|root,COG4974@2|Bacteria,2J5UZ@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMS1_k127_1434273_3	906968.Trebr_0959	1.9e-74	256.0	COG5405@1|root,COG5405@2|Bacteria,2J608@203691|Spirochaetes	203691|Spirochaetes	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
MMS1_k127_1434273_0	889378.Spiaf_2109	4.629e-195	620.0	COG1220@1|root,COG1220@2|Bacteria,2J68E@203691|Spirochaetes	203691|Spirochaetes	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
MMS1_k127_1434273_4	665571.STHERM_c09070	1.171e-47	174.0	COG1815@1|root,COG1815@2|Bacteria,2J804@203691|Spirochaetes	203691|Spirochaetes	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
MMS1_k127_1434273_2	665571.STHERM_c09080	1.022e-76	258.0	COG1558@1|root,COG1558@2|Bacteria,2J7Q7@203691|Spirochaetes	203691|Spirochaetes	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
MMS1_k127_1434273_6	1123274.KB899413_gene856	1.745e-19	91.0	COG1677@1|root,COG1677@2|Bacteria,2J8B3@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-basal body complex protein	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
MMS1_k127_1434273_1	665571.STHERM_c09100	4.474e-184	589.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
MMS1_k127_1434626_0	760011.Spico_1658	1.495e-169	541.0	COG1129@1|root,COG1129@2|Bacteria,2J6Z7@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
MMS1_k127_1434626_1	158189.SpiBuddy_2230	4.455e-108	357.0	COG1172@1|root,COG1172@2|Bacteria,2J826@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K10560	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
MMS1_k127_1436019_1	96561.Dole_2289	3.578e-42	158.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMS1_k127_1436019_5	292459.STH3142	1.072e-24	108.0	COG4231@1|root,COG4231@2|Bacteria,1VIY6@1239|Firmicutes,24PDQ@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_1436019_4	889378.Spiaf_2043	8.157e-32	132.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K03577	-	M00647	-	-	ko00000,ko00002,ko03000	-	-	-	TetR_C_6,TetR_N
MMS1_k127_1436019_3	395493.BegalDRAFT_2956	1.341e-34	141.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,1RSEU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the phosphoglycerate mutase family	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5997	His_Phos_1
MMS1_k127_1436019_2	1280686.AUKE01000024_gene1575	1.121e-37	160.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,4BY1A@830|Butyrivibrio	186801|Clostridia	F	Amidohydrolase family	mtaD	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS1_k127_1436019_0	889378.Spiaf_2605	1.036e-284	889.0	COG1523@1|root,COG1523@2|Bacteria,2J61K@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
MMS1_k127_1436046_1	926562.Oweho_0545	1.713e-94	321.0	COG0612@1|root,COG0612@2|Bacteria,4NDXM@976|Bacteroidetes,1HYCC@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS1_k127_1436046_0	1121451.DESAM_20123	4.825e-170	541.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,42MH1@68525|delta/epsilon subdivisions,2WJD7@28221|Deltaproteobacteria,2MAWC@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Na+-transporting oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
MMS1_k127_1436046_2	1449050.JNLE01000003_gene2262	1.84e-36	147.0	COG1018@1|root,COG1018@2|Bacteria,1TREA@1239|Firmicutes,24IQR@186801|Clostridia,36IU7@31979|Clostridiaceae	186801|Clostridia	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1436095_3	1307761.L21SP2_3247	3.906e-91	310.0	COG0604@1|root,COG0604@2|Bacteria,2JB5M@203691|Spirochaetes	203691|Spirochaetes	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_1436095_1	177437.HRM2_38930	5.972e-123	422.0	COG0784@1|root,COG2984@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MHWA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Response_reg
MMS1_k127_1436095_7	290402.Cbei_2157	8.667e-35	137.0	COG0346@1|root,COG0346@2|Bacteria,1VD8Q@1239|Firmicutes,24JY7@186801|Clostridia,36K1K@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
MMS1_k127_1436095_8	530564.Psta_1453	2.045e-18	93.0	COG2188@1|root,COG2188@2|Bacteria,2J45T@203682|Planctomycetes	203682|Planctomycetes	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
MMS1_k127_1436095_6	907348.TresaDRAFT_0190	1.024e-40	168.0	COG0642@1|root,COG2205@2|Bacteria,2J63U@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_1436095_5	158190.SpiGrapes_2920	5.045e-61	218.0	COG0745@1|root,COG0745@2|Bacteria,2J7CF@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1436095_4	880073.Calab_0506	1.919e-67	243.0	COG0845@1|root,COG0845@2|Bacteria,2NQN5@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
MMS1_k127_1436095_0	945713.IALB_0217	6.248e-145	476.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
MMS1_k127_1436836_0	517418.Ctha_1030	1.728e-161	516.0	COG2710@1|root,COG2710@2|Bacteria,1FDCK@1090|Chlorobi	1090|Chlorobi	H	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
MMS1_k127_1436836_1	290512.Paes_1631	1.252e-21	95.0	COG2710@1|root,COG2710@2|Bacteria,1FDJS@1090|Chlorobi	1090|Chlorobi	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	-	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
MMS1_k127_1439551_4	1480694.DC28_02325	1.914e-19	89.0	COG1766@1|root,COG1766@2|Bacteria,2J5KB@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar M-ring protein	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
MMS1_k127_1439551_1	1307761.L21SP2_1176	2.646e-172	545.0	COG1536@1|root,COG1536@2|Bacteria,2J5CI@203691|Spirochaetes	203691|Spirochaetes	N	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
MMS1_k127_1439551_2	1307761.L21SP2_1178	5.447e-92	311.0	COG1317@1|root,COG1317@2|Bacteria,2J5KZ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
MMS1_k127_1439551_0	744872.Spica_1667	2.786e-176	562.0	COG1157@1|root,COG1157@2|Bacteria,2J5IJ@203691|Spirochaetes	203691|Spirochaetes	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_1439551_5	273068.TTE1438	0.0006797	48.0	COG2882@1|root,COG2882@2|Bacteria,1VHRK@1239|Firmicutes,24UCS@186801|Clostridia,42H95@68295|Thermoanaerobacterales	186801|Clostridia	N	TIGRFAM flagellar export	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
MMS1_k127_1439551_3	573413.Spirs_1567	8.953e-46	172.0	COG3334@1|root,COG3334@2|Bacteria,2J66F@203691|Spirochaetes	203691|Spirochaetes	S	PFAM MgtE intracellular	flbB	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	-
MMS1_k127_143966_0	1094980.Mpsy_0445	1.862e-111	377.0	COG2195@1|root,arCOG05229@2157|Archaea,2Y380@28890|Euryarchaeota,2NAGH@224756|Methanomicrobia	224756|Methanomicrobia	E	Peptidase family M20/M25/M40	-	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M20
MMS1_k127_143966_2	290397.Adeh_0483	9.716e-74	267.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,437VH@68525|delta/epsilon subdivisions,2X354@28221|Deltaproteobacteria,2YUAY@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
MMS1_k127_143966_3	1280692.AUJL01000001_gene167	3.466e-36	142.0	2C5N5@1|root,32Y15@2|Bacteria,1VEIC@1239|Firmicutes,24I2X@186801|Clostridia,36VBS@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_143966_1	1307761.L21SP2_2588	4.811e-79	273.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS1_k127_1442646_2	573413.Spirs_4037	4.002e-83	285.0	COG1692@1|root,COG1692@2|Bacteria,2J6ZK@203691|Spirochaetes	203691|Spirochaetes	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
MMS1_k127_1442646_0	744872.Spica_2766	6.018e-144	465.0	COG2201@1|root,COG2201@2|Bacteria,2J62V@203691|Spirochaetes	203691|Spirochaetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1442646_1	1307761.L21SP2_3302	2.208e-114	375.0	COG1352@1|root,COG1352@2|Bacteria,2J5XY@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
MMS1_k127_1442646_5	1047013.AQSP01000132_gene1732	3.656e-11	71.0	COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
MMS1_k127_1442646_4	1480694.DC28_08650	8.743e-16	84.0	28XQQ@1|root,2ZJMD@2|Bacteria,2J8Q3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LptC
MMS1_k127_1442646_3	545695.TREAZ_1874	6.125e-37	147.0	COG1934@1|root,COG1934@2|Bacteria,2J7U8@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
MMS1_k127_1442646_6	243275.TDE_0644	8.455e-07	51.0	COG1137@1|root,COG1137@2|Bacteria,2J5CM@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
MMS1_k127_1443098_5	1480694.DC28_14355	1.21e-82	278.0	COG0087@1|root,COG0087@2|Bacteria,2J633@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMS1_k127_1443098_4	573413.Spirs_0956	1.073e-92	308.0	COG0088@1|root,COG0088@2|Bacteria,2J5NS@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMS1_k127_1443098_21	573413.Spirs_0957	8.758e-29	118.0	COG0089@1|root,COG0089@2|Bacteria,2J85B@203691|Spirochaetes	203691|Spirochaetes	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMS1_k127_1443098_2	1307761.L21SP2_0880	2.229e-130	420.0	COG0090@1|root,COG0090@2|Bacteria,2J5G3@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
MMS1_k127_1443098_16	889378.Spiaf_0558	4.363e-43	158.0	COG0185@1|root,COG0185@2|Bacteria,2J8DX@203691|Spirochaetes	203691|Spirochaetes	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMS1_k127_1443098_15	573413.Spirs_0960	5.083e-45	165.0	COG0091@1|root,COG0091@2|Bacteria,2J7KV@203691|Spirochaetes	203691|Spirochaetes	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMS1_k127_1443098_3	1123274.KB899411_gene3107	3.331e-106	348.0	COG0092@1|root,COG0092@2|Bacteria,2J5AK@203691|Spirochaetes	203691|Spirochaetes	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMS1_k127_1443098_11	1480694.DC28_14320	9.996e-61	211.0	COG0197@1|root,COG0197@2|Bacteria,2J7H3@203691|Spirochaetes	203691|Spirochaetes	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS1_k127_1443098_24	1313294.BPA_0101300	6.982e-15	76.0	COG0255@1|root,COG0255@2|Bacteria,2J96Q@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMS1_k127_1443098_19	744872.Spica_0394	5.569e-30	121.0	COG0186@1|root,COG0186@2|Bacteria,2J8JX@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMS1_k127_1443098_12	1480694.DC28_14305	4.768e-56	198.0	COG0093@1|root,COG0093@2|Bacteria,2J7N1@203691|Spirochaetes	203691|Spirochaetes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMS1_k127_1443098_18	744872.Spica_0396	1.885e-37	144.0	COG0198@1|root,COG0198@2|Bacteria,2J809@203691|Spirochaetes	203691|Spirochaetes	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
MMS1_k127_1443098_6	545695.TREAZ_2663	2.264e-82	277.0	COG0094@1|root,COG0094@2|Bacteria,2J5DT@203691|Spirochaetes	203691|Spirochaetes	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMS1_k127_1443098_20	573413.Spirs_0968	3.55e-29	116.0	COG0199@1|root,COG0199@2|Bacteria,2J8U1@203691|Spirochaetes	203691|Spirochaetes	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMS1_k127_1443098_9	1480694.DC28_14290	3.091e-63	218.0	COG0096@1|root,COG0096@2|Bacteria,2J7SM@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMS1_k127_1443098_7	1480694.DC28_14285	6.707e-75	255.0	COG0097@1|root,COG0097@2|Bacteria,2J7WB@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMS1_k127_1443098_17	1123274.KB899411_gene3097	7.633e-39	147.0	COG0256@1|root,COG0256@2|Bacteria,2J7YP@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
MMS1_k127_1443098_8	1480694.DC28_14275	2.022e-70	241.0	COG0098@1|root,COG0098@2|Bacteria,2J60F@203691|Spirochaetes	203691|Spirochaetes	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMS1_k127_1443098_22	665571.STHERM_c05140	9.446e-18	85.0	COG1841@1|root,COG1841@2|Bacteria,2J9BZ@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L30p/L7e	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMS1_k127_1443098_14	596324.TREVI0001_1853	3.785e-47	173.0	COG0200@1|root,COG0200@2|Bacteria,2J7ZW@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMS1_k127_1443098_0	1123274.KB899411_gene3093	3.943e-194	614.0	COG0201@1|root,COG0201@2|Bacteria,2J5BH@203691|Spirochaetes	203691|Spirochaetes	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
MMS1_k127_1443098_23	760011.Spico_1695	3.219e-15	75.0	COG0257@1|root,COG0257@2|Bacteria,2J989@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
MMS1_k127_1443098_13	744872.Spica_0407	1.317e-54	193.0	COG0099@1|root,COG0099@2|Bacteria,2J7QU@203691|Spirochaetes	203691|Spirochaetes	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMS1_k127_1443098_10	906968.Trebr_2272	1.847e-61	213.0	COG0100@1|root,COG0100@2|Bacteria,2J7BP@203691|Spirochaetes	203691|Spirochaetes	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS1_k127_1443098_1	573413.Spirs_0980	5.656e-161	512.0	COG0202@1|root,COG0202@2|Bacteria,2J58K@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
MMS1_k127_1444874_1	658086.HMPREF0994_03662	4.483e-72	249.0	COG3408@1|root,COG3408@2|Bacteria,1UDA2@1239|Firmicutes,24A9K@186801|Clostridia,27REM@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_1444874_0	1382359.JIAL01000001_gene240	7.172e-106	355.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1446044_6	1122951.ATUE01000006_gene1345	1.696e-06	50.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,3NIEZ@468|Moraxellaceae	1236|Gammaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMS1_k127_1446044_2	1123274.KB899425_gene2746	2.343e-72	247.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
MMS1_k127_1446044_3	326424.FRAAL2583	4.059e-32	133.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
MMS1_k127_1446044_0	398512.JQKC01000020_gene4070	7.918e-82	279.0	COG0483@1|root,COG0483@2|Bacteria,1TR4E@1239|Firmicutes,24KJZ@186801|Clostridia,3WM19@541000|Ruminococcaceae	186801|Clostridia	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
MMS1_k127_1446044_4	1122990.BAJH01000006_gene1062	8.05e-29	116.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
MMS1_k127_1446044_1	1410668.JNKC01000017_gene2765	3.321e-75	262.0	COG2207@1|root,COG2207@2|Bacteria,1TQDS@1239|Firmicutes,24907@186801|Clostridia,36ENI@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, arac family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_1446267_0	332101.JIBU02000002_gene4610	8.199e-78	272.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,36FEA@31979|Clostridiaceae	186801|Clostridia	C	nitroreductase	sagB	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_1446267_2	246194.CHY_0595	3.165e-26	116.0	COG0655@1|root,COG0655@2|Bacteria,1W6V4@1239|Firmicutes,25NF0@186801|Clostridia,42IKR@68295|Thermoanaerobacterales	186801|Clostridia	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_1446267_1	1173023.KE650771_gene598	8.18e-28	125.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1JK6S@1189|Stigonemataceae	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
MMS1_k127_1449460_1	1132441.KI519455_gene3683	1.164e-87	297.0	COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,1W9AJ@1268|Micrococcaceae	201174|Actinobacteria	C	oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1449460_0	1499967.BAYZ01000190_gene3814	3.975e-142	458.0	COG1882@1|root,COG1882@2|Bacteria	2|Bacteria	C	formate C-acetyltransferase activity	ybiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
MMS1_k127_1450030_1	1123274.KB899418_gene2333	1.024e-90	305.0	COG4383@1|root,COG4383@2|Bacteria	2|Bacteria	L	Mu-like prophage protein gp29	gp29	-	-	-	-	-	-	-	-	-	-	-	DUF935
MMS1_k127_1450030_0	1123274.KB899418_gene2334	6.314e-114	376.0	COG4373@1|root,COG4373@2|Bacteria,2J9X9@203691|Spirochaetes	2|Bacteria	S	Mu-like prophage FluMu protein gp28	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
MMS1_k127_1450086_2	1149133.ppKF707_4242	2.853e-21	95.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,1RP80@1236|Gammaproteobacteria,1YHFR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	ydiF	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016043,GO:0016740,GO:0016782,GO:0019752,GO:0022607,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840	2.8.3.1,2.8.3.8	ko:K01026,ko:K19709	ko00620,ko00627,ko00640,ko00643,ko00650,ko01100,ko01120,map00620,map00627,map00640,map00643,map00650,map01100,map01120	-	R00928,R01179,R01359,R01449,R05508,R07832	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
MMS1_k127_1450086_0	1304284.L21TH_1977	2.586e-197	623.0	COG2610@1|root,COG2610@2|Bacteria,1TQJ6@1239|Firmicutes,24839@186801|Clostridia,36DCD@31979|Clostridiaceae	186801|Clostridia	EG	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	GntP_permease,Na_H_antiporter
MMS1_k127_1450086_1	207954.MED92_01771	1.352e-33	134.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1XH77@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_1450345_6	1121920.AUAU01000024_gene2355	9.231e-64	242.0	COG0074@1|root,COG0074@2|Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	2.3.3.8,6.2.1.5	ko:K01902,ko:K15230,ko:K15233	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00352,R00405,R01322,R02404	RC00004,RC00014,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0306	Citrate_synt,CoA_binding,Ligase_CoA,Succ_CoA_lig
MMS1_k127_1450345_5	1218084.BBJK01000089_gene5913	1.037e-67	246.0	COG0045@1|root,COG0045@2|Bacteria,1PYM0@1224|Proteobacteria,2W8VT@28216|Betaproteobacteria,1K6TP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	ATP citrate lyase citrate-binding	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_2,Citrate_bind
MMS1_k127_1450345_9	768671.ThimaDRAFT_3756	1.403e-05	53.0	COG4372@1|root,COG4372@2|Bacteria,1RIXK@1224|Proteobacteria,1SARF@1236|Gammaproteobacteria,1WZ5Q@135613|Chromatiales	135613|Chromatiales	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1450345_1	1123274.KB899406_gene1128	1.504e-151	486.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMS1_k127_1450345_0	573413.Spirs_3446	1.064e-152	490.0	COG0842@1|root,COG0842@2|Bacteria,2JA86@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMS1_k127_1450345_3	1123274.KB899406_gene1130	2.344e-113	370.0	COG1131@1|root,COG1131@2|Bacteria,2J7KJ@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_1450345_2	573413.Spirs_3444	1.018e-116	383.0	COG1131@1|root,COG1131@2|Bacteria,2JA8P@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_1450345_8	1121904.ARBP01000025_gene6061	3.043e-37	152.0	COG0845@1|root,COG0845@2|Bacteria,4NGVX@976|Bacteroidetes,47JCQ@768503|Cytophagia	976|Bacteroidetes	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
MMS1_k127_1450345_4	573413.Spirs_3442	5.763e-77	273.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS1_k127_1450345_7	573413.Spirs_3441	1.068e-49	183.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
MMS1_k127_1451126_2	1123274.KB899415_gene2540	1.961e-25	122.0	COG2199@1|root,COG2199@2|Bacteria	2|Bacteria	T	diguanylate cyclase activity	-	-	2.7.7.65	ko:K02065,ko:K21023	ko02010,ko02025,map02010,map02025	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.27	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,HlyD_D23,PAS_9,Response_reg
MMS1_k127_1451126_1	1123274.KB899415_gene2541	3.681e-52	194.0	COG1355@1|root,COG1355@2|Bacteria,2J7WY@203691|Spirochaetes	203691|Spirochaetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMS1_k127_1451126_0	1123274.KB899415_gene2542	3.587e-129	431.0	COG2604@1|root,COG2604@2|Bacteria,2J5FD@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
MMS1_k127_1453045_3	386456.JQKN01000016_gene919	3.73e-16	80.0	COG1309@1|root,arCOG02648@2157|Archaea,2XYP9@28890|Euryarchaeota,23PMJ@183925|Methanobacteria	183925|Methanobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1453045_0	1094508.Tsac_2240	3.618e-141	451.0	COG1348@1|root,COG1348@2|Bacteria,1TPXR@1239|Firmicutes,247KJ@186801|Clostridia,42FGN@68295|Thermoanaerobacterales	186801|Clostridia	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02400	Fer4_NifH
MMS1_k127_1453045_2	880072.Desac_0351	4.376e-44	162.0	COG0347@1|root,COG0347@2|Bacteria,1RIX2@1224|Proteobacteria,42SFQ@68525|delta/epsilon subdivisions,2WPG3@28221|Deltaproteobacteria,2MRTZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
MMS1_k127_1453045_1	573413.Spirs_3006	1.169e-46	171.0	COG0347@1|root,COG0347@2|Bacteria,2J8HK@203691|Spirochaetes	203691|Spirochaetes	K	nitrogen regulatory protein P-II	-	-	-	ko:K02590	-	-	-	-	ko00000	-	-	-	P-II
MMS1_k127_1453045_4	118168.MC7420_2852	0.0001945	46.0	COG2710@1|root,COG2710@2|Bacteria,1G296@1117|Cyanobacteria,1H93A@1150|Oscillatoriales	1117|Cyanobacteria	C	Nitrogenase molybdenum-iron protein, alpha	-	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
MMS1_k127_1454172_2	658655.HMPREF0988_02766	1.782e-67	244.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UNTF@1239|Firmicutes,248YN@186801|Clostridia,27M1Y@186928|unclassified Lachnospiraceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
MMS1_k127_1454172_1	324602.Caur_0360	4.434e-173	553.0	COG2723@1|root,COG2723@2|Bacteria,2G5QE@200795|Chloroflexi,3774T@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
MMS1_k127_1454172_0	1122919.KB905569_gene2971	4.435e-238	748.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,4HBDB@91061|Bacilli,26TD5@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
MMS1_k127_1454172_3	658655.HMPREF0988_02759	3.96e-20	92.0	COG0657@1|root,COG0657@2|Bacteria,1TP1H@1239|Firmicutes,24D7F@186801|Clostridia,27TY4@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
MMS1_k127_1454172_5	935837.JAEK01000013_gene4916	2.948e-10	64.0	COG0657@1|root,COG0657@2|Bacteria,1V212@1239|Firmicutes,4IQCI@91061|Bacilli,1ZRIR@1386|Bacillus	91061|Bacilli	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1454172_4	1307436.PBF_23859	1.995e-14	81.0	COG1309@1|root,COG1309@2|Bacteria,1UW6C@1239|Firmicutes,4I43F@91061|Bacilli,1ZCG2@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1455361_1	658659.HMPREF0983_00297	1.528e-22	99.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,3VNWI@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
MMS1_k127_1455361_0	748449.Halha_0439	2.021e-115	380.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WAI0@53433|Halanaerobiales	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS1_k127_1455361_2	1134413.ANNK01000156_gene3632	1.514e-06	58.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_3_3
MMS1_k127_1456246_2	1443125.Z962_03165	6.107e-20	98.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC4@186801|Clostridia,36WT9@31979|Clostridiaceae	186801|Clostridia	EH	Amino-transferase class IV	ilvE2	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS1_k127_1456246_0	1307761.L21SP2_2631	2.915e-138	450.0	COG1820@1|root,COG1820@2|Bacteria,2J5F5@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS1_k127_1456246_1	1480694.DC28_09525	3.541e-114	373.0	COG1653@1|root,COG1653@2|Bacteria,2J5W6@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_145648_0	573413.Spirs_1232	1.574e-152	507.0	COG0383@1|root,COG0383@2|Bacteria,2J78B@203691|Spirochaetes	203691|Spirochaetes	G	family 38 N-terminal domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
MMS1_k127_145648_2	1410650.JHWL01000036_gene645	4.972e-114	388.0	COG0613@1|root,COG0613@2|Bacteria,1UGGC@1239|Firmicutes,24DXT@186801|Clostridia,4BY5A@830|Butyrivibrio	186801|Clostridia	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_145648_1	324057.Pjdr2_3723	6.128e-138	459.0	COG0747@1|root,COG0747@2|Bacteria,1TXR4@1239|Firmicutes,4I6SP@91061|Bacilli,26UR3@186822|Paenibacillaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS1_k127_145648_3	1408424.JHYI01000014_gene1253	1.246e-105	351.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HATR@91061|Bacilli,1ZCAV@1386|Bacillus	91061|Bacilli	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	appB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0022857,GO:0051179,GO:0051234,GO:0055085	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS1_k127_1461902_3	573413.Spirs_3353	1.36e-46	173.0	COG0280@1|root,COG0280@2|Bacteria,2J9KM@203691|Spirochaetes	203691|Spirochaetes	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
MMS1_k127_1461902_2	1307761.L21SP2_0955	2.885e-109	364.0	COG3426@1|root,COG3426@2|Bacteria	2|Bacteria	C	butyrate kinase activity	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase,PTA_PTB
MMS1_k127_1461902_1	1307761.L21SP2_0954	9.419e-136	442.0	COG0436@1|root,COG0436@2|Bacteria,2J6QM@203691|Spirochaetes	203691|Spirochaetes	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_1461902_4	862965.PARA_05160	2.067e-41	160.0	COG2964@1|root,COG2964@2|Bacteria,1MU5K@1224|Proteobacteria,1RPDQ@1236|Gammaproteobacteria,1Y72V@135625|Pasteurellales	135625|Pasteurellales	S	protein conserved in bacteria	Z012_00570	-	-	-	-	-	-	-	-	-	-	-	HTH_22,PAS_6
MMS1_k127_1461902_5	545694.TREPR_3806	2.046e-14	82.0	2F1GG@1|root,33UH1@2|Bacteria,2J7U4@203691|Spirochaetes	203691|Spirochaetes	S	(Type IV) pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
MMS1_k127_1461902_6	744872.Spica_1336	8.042e-13	78.0	2AMQG@1|root,31CKP@2|Bacteria,2J7X3@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1461902_0	1033810.HLPCO_000985	1.126e-143	468.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csdA	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMS1_k127_1462886_1	1499967.BAYZ01000184_gene4608	2.227e-115	389.0	COG0477@1|root,COG1413@1|root,COG1413@2|Bacteria,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	DNA_alkylation,HEAT_2,MFS_1,cNMP_binding
MMS1_k127_1462886_0	177439.DP0462	3.783e-157	507.0	COG2199@1|root,COG3706@2|Bacteria,1N9PI@1224|Proteobacteria,42MQF@68525|delta/epsilon subdivisions,2WIUE@28221|Deltaproteobacteria,2MJ68@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
MMS1_k127_1462954_1	1121101.HMPREF1532_00976	4.87e-142	458.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FN74@200643|Bacteroidia,4AKXQ@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
MMS1_k127_1462954_2	1121859.KB890756_gene1411	1.604e-132	431.0	COG0673@1|root,COG0673@2|Bacteria,4NG0T@976|Bacteroidetes	976|Bacteroidetes	S	Pfam Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
MMS1_k127_1462954_3	1121101.HMPREF1532_00975	5.024e-77	271.0	COG5012@1|root,COG5012@2|Bacteria,4NK9D@976|Bacteroidetes,2FQBD@200643|Bacteroidia,4AMD4@815|Bacteroidaceae	976|Bacteroidetes	E	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
MMS1_k127_1462954_0	1380600.AUYN01000003_gene250	1.053e-159	514.0	COG1322@1|root,COG1322@2|Bacteria	2|Bacteria	S	DNA recombination	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
MMS1_k127_1462954_4	65093.PCC7418_0942	1.593e-54	201.0	COG2197@1|root,COG2197@2|Bacteria,1G33W@1117|Cyanobacteria	1117|Cyanobacteria	KT	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_1462954_5	266117.Rxyl_1551	4.267e-32	136.0	COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4CU1W@84995|Rubrobacteria	84995|Rubrobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
MMS1_k127_1464822_6	1173028.ANKO01000158_gene4530	1.287e-19	91.0	2EWB0@1|root,33PPQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1464822_1	1191523.MROS_0615	4.651e-169	541.0	COG0001@1|root,COG0001@2|Bacteria	2|Bacteria	H	glutamate-1-semialdehyde 2,1-aminomutase activity	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSB619.SA_RS08395,iUMNK88_1353.UMNK88_158	Aminotran_3
MMS1_k127_1464822_4	387092.NIS_1776	1.246e-74	263.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,43B09@68525|delta/epsilon subdivisions,2YMJI@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1464822_3	439235.Dalk_3856	8.722e-136	441.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
MMS1_k127_1464822_2	246194.CHY_1210	1.186e-137	444.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,42EWI@68295|Thermoanaerobacterales	186801|Clostridia	H	Delta-aminolevulinic acid dehydratase	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS15750	ALAD
MMS1_k127_1464822_0	667014.Thein_0362	1.86e-193	609.0	COG0535@1|root,COG0535@2|Bacteria,2GGXI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS1_k127_1464822_5	1123371.ATXH01000018_gene1410	6.16e-45	171.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GH4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
MMS1_k127_1466635_0	610130.Closa_1434	1.34e-141	460.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,21XVZ@1506553|Lachnoclostridium	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_1466635_1	1226325.HMPREF1548_06814	1.033e-121	412.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,36GKI@31979|Clostridiaceae	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_1466635_2	1122919.KB905572_gene3602	6.468e-89	301.0	COG0395@1|root,COG0395@2|Bacteria,1U0R6@1239|Firmicutes,4HBVR@91061|Bacilli,26S5T@186822|Paenibacillaceae	91061|Bacilli	G	ABC-type sugar transport system, permease component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1466635_3	1298598.JCM21714_2293	1.646e-43	160.0	COG1175@1|root,COG1175@2|Bacteria,1TQX5@1239|Firmicutes,4HHM3@91061|Bacilli	91061|Bacilli	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1469926_4	1047013.AQSP01000105_gene1448	1.029e-06	52.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
MMS1_k127_1469926_2	1047013.AQSP01000105_gene1449	1.982e-16	81.0	COG3668@1|root,COG3668@2|Bacteria	2|Bacteria	D	Plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
MMS1_k127_1469926_1	56110.Oscil6304_5139	5.906e-47	191.0	COG4974@1|root,COG4974@2|Bacteria,1G7AU@1117|Cyanobacteria,1HHKG@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
MMS1_k127_1469926_0	889378.Spiaf_1768	1.585e-151	495.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS1_k127_1469926_3	877418.ATWV01000007_gene2331	5.816e-13	81.0	COG1233@1|root,COG1233@2|Bacteria,2J694@203691|Spirochaetes	203691|Spirochaetes	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
MMS1_k127_1476832_1	1289135.A966_05488	3.404e-30	131.0	COG1994@1|root,COG1994@2|Bacteria,2J7KI@203691|Spirochaetes	203691|Spirochaetes	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS1_k127_1476832_0	1031288.AXAA01000031_gene111	2.532e-74	265.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,36E2S@31979|Clostridiaceae	186801|Clostridia	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS1_k127_1476832_2	1203606.HMPREF1526_01584	3.519e-19	100.0	2AFBR@1|root,315B7@2|Bacteria,1VBIP@1239|Firmicutes,24DJU@186801|Clostridia,36GH2@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1479361_4	1123274.KB899406_gene1142	8.38e-53	199.0	COG0840@1|root,COG4624@1|root,COG0840@2|Bacteria,COG4624@2|Bacteria,2J5UI@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,MCPsignal
MMS1_k127_1479361_2	545694.TREPR_1265	1.821e-116	380.0	COG2086@1|root,COG2086@2|Bacteria,2J6CP@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein	etfB	-	1.3.1.108	ko:K03521,ko:K22431	-	-	-	-	ko00000,ko01000	-	-	-	ETF
MMS1_k127_1479361_1	545694.TREPR_1266	3.22e-135	438.0	COG2025@1|root,COG2025@2|Bacteria,2J5XR@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS1_k127_1479361_0	545694.TREPR_1267	1.538e-232	732.0	COG1960@1|root,COG1960@2|Bacteria,2J5X1@203691|Spirochaetes	203691|Spirochaetes	C	Acyl-CoA dehydrogenase, C-terminal domain	fadE	-	-	ko:K15980	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
MMS1_k127_1479361_3	1278307.KB907002_gene417	1.474e-59	212.0	COG0834@1|root,COG0834@2|Bacteria,1RJVV@1224|Proteobacteria,1SBD1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_1488267_2	1280692.AUJL01000008_gene2386	2.72e-05	47.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,36EA6@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
MMS1_k127_1488267_1	1480694.DC28_15190	8.711e-63	224.0	COG0569@1|root,COG0569@2|Bacteria,2J7SR@203691|Spirochaetes	203691|Spirochaetes	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
MMS1_k127_1488267_0	1480694.DC28_15195	2.252e-108	366.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	ntpJ	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMS1_k127_1490637_2	744872.Spica_0617	1.594e-187	593.0	COG2233@1|root,COG2233@2|Bacteria,2J5WY@203691|Spirochaetes	203691|Spirochaetes	F	Uracil permease	-	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
MMS1_k127_1490637_4	1499967.BAYZ01000182_gene4423	3.82e-73	256.0	COG1319@1|root,COG1319@2|Bacteria,2NQ9S@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS1_k127_1490637_5	511051.CSE_07190	8.441e-57	201.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	coxS	-	1.2.5.3,1.3.99.16,1.3.99.8,1.5.99.14,1.5.99.4	ko:K03518,ko:K07302,ko:K13483,ko:K16879,ko:K19186,ko:K19819,ko:K20172	ko00230,ko00365,ko00760,ko01100,ko01120,map00230,map00365,map00760,map01100,map01120	M00546,M00810,M00811	R01768,R02103,R02860,R02987,R07514,R07946,R11168,R11179	RC00143,RC00589,RC01856,RC01860,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0374c	Fer2,Fer2_2
MMS1_k127_1490637_0	511051.CSE_07200	0.0	1086.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS1_k127_1490637_3	1449126.JQKL01000016_gene2875	1.786e-145	477.0	COG0074@1|root,COG0074@2|Bacteria,1UJ4F@1239|Firmicutes,24AQG@186801|Clostridia	186801|Clostridia	C	Succinyl-CoA synthetase, alpha subunit	-	-	-	ko:K02381	-	-	-	-	ko00000	-	-	-	CoA_binding,DUF1116,Ligase_CoA
MMS1_k127_1490637_1	158189.SpiBuddy_2606	1.151e-197	627.0	COG0074@1|root,COG0074@2|Bacteria,2J9PD@203691|Spirochaetes	203691|Spirochaetes	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,DUF1116,Ligase_CoA
MMS1_k127_1492823_1	388413.ALPR1_07940	8.52e-71	249.0	COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,47PDQ@768503|Cytophagia	976|Bacteroidetes	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1492823_0	1511.CLOST_2539	1.53e-92	314.0	COG0384@1|root,COG0384@2|Bacteria,1TSV5@1239|Firmicutes,25D2E@186801|Clostridia,25S59@186804|Peptostreptococcaceae	186801|Clostridia	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
MMS1_k127_1492823_2	877418.ATWV01000002_gene1101	1.986e-30	124.0	COG1406@1|root,COG1406@2|Bacteria,2J8FY@203691|Spirochaetes	203691|Spirochaetes	N	CheC-like family	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
MMS1_k127_150061_0	1232437.KL661982_gene3739	5.08e-56	222.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,42QAQ@68525|delta/epsilon subdivisions,2WJQN@28221|Deltaproteobacteria,2MJ4A@213118|Desulfobacterales	1224|Proteobacteria	K	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3'	malT	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE,TPR_19,TPR_4,TPR_8
MMS1_k127_150061_3	1232437.KL661982_gene3740	2.726e-05	49.0	2DNVA@1|root,32ZBE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_150061_1	272559.BF9343_1708	1.197e-26	120.0	COG1149@1|root,COG1149@2|Bacteria,4PM3E@976|Bacteroidetes,2G0AI@200643|Bacteroidia,4ATBJ@815|Bacteroidaceae	976|Bacteroidetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_150061_2	1449050.JNLE01000003_gene2356	9.746e-22	104.0	COG0596@1|root,COG0596@2|Bacteria,1UYIN@1239|Firmicutes,25BVF@186801|Clostridia,36WN9@31979|Clostridiaceae	186801|Clostridia	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS1_k127_1505673_1	1313304.CALK_1970	4.802e-95	317.0	COG0825@1|root,COG0825@2|Bacteria	2|Bacteria	I	malonyl-CoA biosynthetic process	accA	GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN678.accA,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197	ACCA
MMS1_k127_1505673_0	1313304.CALK_1971	3.788e-182	575.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria	2|Bacteria	C	pyruvate	oadA	-	2.1.3.1,2.3.1.12,4.1.1.3,6.4.1.1,6.4.1.7	ko:K00627,ko:K01571,ko:K01960,ko:K02160,ko:K03416,ko:K20140	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00307,M00376,M00620	R00209,R00217,R00344,R00353,R00742,R00930,R02569	RC00004,RC00040,RC00097,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	iJN746.PP_5346	Biotin_lipoyl,HMGL-like,PYC_OADA
MMS1_k127_1508141_0	338969.Rfer_3395	1.201e-57	217.0	COG0457@1|root,COG2202@1|root,COG5001@1|root,COG0457@2|Bacteria,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
MMS1_k127_1508436_1	865861.AZSU01000001_gene346	1.152e-152	490.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	mglA	-	3.6.3.17	ko:K10542	ko02010,map02010	M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.3	-	-	ABC_tran
MMS1_k127_1508436_2	1125699.HMPREF9194_01698	6.658e-121	397.0	COG1879@1|root,COG1879@2|Bacteria,2J6MC@203691|Spirochaetes	203691|Spirochaetes	G	COG1879 ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439,ko:K10540,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00214,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	Peripla_BP_4
MMS1_k127_1508436_3	404380.Gbem_0788	2.729e-66	237.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42QZK@68525|delta/epsilon subdivisions,2WMZB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
MMS1_k127_1508436_4	765912.Thimo_0508	1.375e-57	209.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
MMS1_k127_1508436_0	313628.LNTAR_09144	2.094e-295	939.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_1508436_5	768671.ThimaDRAFT_3756	3.603e-09	64.0	COG4372@1|root,COG4372@2|Bacteria,1RIXK@1224|Proteobacteria,1SARF@1236|Gammaproteobacteria,1WZ5Q@135613|Chromatiales	135613|Chromatiales	S	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1508827_1	877418.ATWV01000003_gene612	4.11e-29	122.0	2EZ7M@1|root,33SDH@2|Bacteria,2J5HE@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1508827_0	469381.Dpep_0412	6.189e-145	465.0	COG1932@1|root,COG1932@2|Bacteria,3TC29@508458|Synergistetes	508458|Synergistetes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMS1_k127_1509058_2	398767.Glov_2934	2.422e-17	94.0	COG5002@1|root,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07642,ko:K18143	ko01501,ko02020,map01501,map02020	M00450,M00645,M00646,M00648,M00649,M00655	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_1509058_1	857293.CAAU_0944	8.403e-52	190.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,36FTB@31979|Clostridiaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	ko:K02483,ko:K18344	ko01502,ko02020,map01502,map02020	M00651,M00656	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1509058_0	889378.Spiaf_1079	2.116e-118	388.0	COG1198@1|root,COG1198@2|Bacteria,2J5B4@203691|Spirochaetes	203691|Spirochaetes	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
MMS1_k127_1509329_0	1307761.L21SP2_2737	1.487e-26	119.0	COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg,dCache_1
MMS1_k127_1509427_0	1480694.DC28_11720	3.588e-117	385.0	COG0167@1|root,COG0167@2|Bacteria,2J610@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,DHO_dh,FAD_binding_6
MMS1_k127_1509427_1	889378.Spiaf_1351	2.195e-49	183.0	COG0543@1|root,COG0543@2|Bacteria,2J8C6@203691|Spirochaetes	203691|Spirochaetes	C	dihydroorotate dehydrogenase	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
MMS1_k127_1510227_0	1279009.ADICEAN_03539	6.734e-112	372.0	COG0389@1|root,COG0389@2|Bacteria,4NF1Y@976|Bacteroidetes,47JB9@768503|Cytophagia	976|Bacteroidetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
MMS1_k127_1515336_0	1235802.C823_03726	3.893e-262	831.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,25YH0@186806|Eubacteriaceae	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_1515809_0	1196323.ALKF01000205_gene4114	4.405e-149	483.0	COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae	91061|Bacilli	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
MMS1_k127_1522629_1	1307761.L21SP2_1717	2.39e-102	346.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_1522629_7	221027.JO40_00800	6.816e-19	87.0	COG0267@1|root,COG0267@2|Bacteria,2J8UW@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
MMS1_k127_1522629_8	158189.SpiBuddy_2863	4.423e-12	69.0	COG0690@1|root,COG0690@2|Bacteria,2J9CX@203691|Spirochaetes	203691|Spirochaetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
MMS1_k127_1522629_3	1123274.KB899411_gene3124	1.489e-80	271.0	COG0250@1|root,COG0250@2|Bacteria,2J7FV@203691|Spirochaetes	203691|Spirochaetes	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
MMS1_k127_1522629_4	665571.STHERM_c04860	2.652e-66	228.0	COG0080@1|root,COG0080@2|Bacteria,2J7BU@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS1_k127_1522629_2	889378.Spiaf_0545	7.875e-100	329.0	COG0081@1|root,COG0081@2|Bacteria,2J5HN@203691|Spirochaetes	203691|Spirochaetes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMS1_k127_1522629_5	1307761.L21SP2_2706	1.552e-46	173.0	COG0244@1|root,COG0244@2|Bacteria,2J74F@203691|Spirochaetes	203691|Spirochaetes	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMS1_k127_1522629_6	1273103.NM10_08224	5.376e-43	160.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,4H4X8@909932|Negativicutes	909932|Negativicutes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
MMS1_k127_1522629_0	889378.Spiaf_0548	9.395e-112	365.0	COG0085@1|root,COG0085@2|Bacteria,2J5JV@203691|Spirochaetes	203691|Spirochaetes	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS1_k127_1523694_2	177437.HRM2_37770	5.31e-41	155.0	COG4120@1|root,COG4120@2|Bacteria,1MXGE@1224|Proteobacteria,42P9P@68525|delta/epsilon subdivisions,2WJPI@28221|Deltaproteobacteria,2MJS5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01989,ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind,BPD_transp_2
MMS1_k127_1523694_0	1307761.L21SP2_2674	9.398e-117	385.0	COG2984@1|root,COG2984@2|Bacteria,2J62D@203691|Spirochaetes	203691|Spirochaetes	S	PFAM ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
MMS1_k127_1523694_1	1254432.SCE1572_41035	1.853e-55	216.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2Z0N9@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
MMS1_k127_1523694_3	536227.CcarbDRAFT_0066	3.343e-09	67.0	COG2197@1|root,COG2197@2|Bacteria,1V0AE@1239|Firmicutes,25K0Z@186801|Clostridia,36NYJ@31979|Clostridiaceae	186801|Clostridia	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
MMS1_k127_1524526_1	1480694.DC28_02420	3.536e-53	195.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
MMS1_k127_1524526_0	573413.Spirs_1580	2.049e-70	246.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
MMS1_k127_1524763_1	1120966.AUBU01000013_gene454	3.382e-43	166.0	28PQP@1|root,2ZCCM@2|Bacteria,4NSQ2@976|Bacteroidetes,47SHE@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
MMS1_k127_1524763_0	1536774.H70357_04815	8.223e-56	201.0	COG0664@1|root,COG0664@2|Bacteria,1V2E0@1239|Firmicutes,4HG8V@91061|Bacilli,26RP4@186822|Paenibacillaceae	91061|Bacilli	T	Cyclic nucleotide-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_1524763_2	1449050.JNLE01000003_gene2829	1.898e-12	68.0	COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia,36IKR@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_1529942_0	889378.Spiaf_1858	6.967e-61	222.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_1529942_1	1298920.KI911353_gene2958	2.473e-25	107.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,220M5@1506553|Lachnoclostridium	186801|Clostridia	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GGDEF,HD,HD_5,PAS_3,Response_reg
MMS1_k127_1529981_2	573413.Spirs_3998	5.21e-32	129.0	COG2201@1|root,COG2201@2|Bacteria	2|Bacteria	NT	protein-glutamate methylesterase activity	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1529981_0	278963.ATWD01000002_gene333	2.255e-93	317.0	COG2201@1|root,COG2201@2|Bacteria,3Y35K@57723|Acidobacteria,2JJ3B@204432|Acidobacteriia	204432|Acidobacteriia	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1529981_1	439235.Dalk_1135	1.797e-37	148.0	COG0840@1|root,COG1293@1|root,COG0840@2|Bacteria,COG1293@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MHVE@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	helical bimodular (HBM) domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HBM,MCPsignal,dCache_1
MMS1_k127_1530442_2	1123274.KB899420_gene4089	2.187e-140	449.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
MMS1_k127_1530442_1	573413.Spirs_0720	5.282e-142	456.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K15771,ko:K17235,ko:K17238,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00207,M00491,M00599,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34,3.A.1.1.38	-	-	BPD_transp_1
MMS1_k127_1530442_0	1123274.KB899420_gene4091	3.137e-189	601.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
MMS1_k127_1530442_3	573413.Spirs_0718	3.095e-98	328.0	COG1737@1|root,COG1737@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
MMS1_k127_1531129_1	1313172.YM304_32550	6.5e-190	605.0	COG0366@1|root,COG0366@2|Bacteria,2GNEC@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase, catalytic domain	gtfA	-	2.4.1.7	ko:K00690	ko00500,map00500	-	R00803	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF1964
MMS1_k127_1531129_3	1321778.HMPREF1982_02521	2.849e-80	276.0	COG0683@1|root,COG0683@2|Bacteria,1TQ31@1239|Firmicutes,24E2W@186801|Clostridia	186801|Clostridia	E	leucine binding	-	-	-	-	-	-	-	-	-	-	-	-	APS_kinase
MMS1_k127_1531129_6	1279009.ADICEAN_02877	1.254e-09	67.0	COG1309@1|root,COG1309@2|Bacteria,4NMR8@976|Bacteroidetes,47PFA@768503|Cytophagia	976|Bacteroidetes	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
MMS1_k127_1531129_2	1196324.A374_17079	2.208e-91	313.0	COG5505@1|root,COG5505@2|Bacteria,1TSC8@1239|Firmicutes,4HBJU@91061|Bacilli	91061|Bacilli	S	integral membrane protein	yjcL	-	-	-	-	-	-	-	-	-	-	-	DUF819
MMS1_k127_1531129_0	1196324.A374_17084	1.32e-190	606.0	COG0076@1|root,COG0076@2|Bacteria,1TPVX@1239|Firmicutes,4HENF@91061|Bacilli	91061|Bacilli	E	Belongs to the group II decarboxylase family	gadB	-	4.1.1.15,4.1.2.27	ko:K01580,ko:K01634	ko00250,ko00410,ko00430,ko00600,ko00650,ko01100,ko01110,ko01120,ko02024,ko04071,ko04727,ko04940,map00250,map00410,map00430,map00600,map00650,map01100,map01110,map01120,map02024,map04071,map04727,map04940	M00027,M00100	R00261,R00489,R01682,R02464,R02466,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
MMS1_k127_1531129_4	443143.GM18_3554	2.11e-14	77.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
MMS1_k127_1531129_5	296591.Bpro_0013	8.283e-14	72.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,2VSZV@28216|Betaproteobacteria,4AEWP@80864|Comamonadaceae	28216|Betaproteobacteria	E	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	2.3.1.30	ko:K00640,ko:K07062	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	PIN
MMS1_k127_1531486_1	56107.Cylst_1289	2.946e-130	440.0	COG4097@1|root,COG5126@1|root,COG4097@2|Bacteria,COG5126@2|Bacteria,1G2G1@1117|Cyanobacteria,1HKUB@1161|Nostocales	1117|Cyanobacteria	P	FAD-binding domain	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,EF-hand_8,FAD_binding_8,Ferric_reduct,NAD_binding_1,NAD_binding_6
MMS1_k127_1531486_0	706587.Desti_1206	2.018e-149	483.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2MQXU@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
MMS1_k127_1531486_2	573413.Spirs_3870	5.728e-52	192.0	COG0584@1|root,COG0584@2|Bacteria,2J689@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
MMS1_k127_1531486_3	1117108.PAALTS15_04758	2.365e-09	61.0	2EPTA@1|root,33HDU@2|Bacteria,1UWBW@1239|Firmicutes,4I7NT@91061|Bacilli,26X43@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1532733_2	762984.HMPREF9445_02499	5.716e-123	403.0	COG2401@1|root,COG2401@2|Bacteria,4PAP9@976|Bacteroidetes,2FXE4@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1532733_3	67352.JODS01000018_gene5707	4.23e-47	176.0	COG0223@1|root,COG0223@2|Bacteria,2ICJZ@201174|Actinobacteria	201174|Actinobacteria	J	Formyl transferase	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_N
MMS1_k127_1532733_4	1322246.BN4_12624	9.201e-39	159.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,439Y8@68525|delta/epsilon subdivisions,2X058@28221|Deltaproteobacteria,2MAKN@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_1532733_0	1229485.AMYV01000031_gene1919	2.44e-176	565.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RP0M@1236|Gammaproteobacteria,1J5MD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	uxaA	GO:0003674,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046872,GO:0046914,GO:0071704,GO:0072329,GO:1901575	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_3836	GD_AH_C,SAF
MMS1_k127_1532733_1	1218086.BBNB01000001_gene3421	8.56e-173	554.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,1RQX5@1236|Gammaproteobacteria,3WX96@544|Citrobacter	1236|Gammaproteobacteria	G	Mannitol dehydrogenase Rossmann domain	uxaB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.57,1.1.1.58	ko:K00040,ko:K00041	ko00040,ko01100,map00040,map01100	M00061,M00631	R02454,R02555	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c17480	Mannitol_dh,Mannitol_dh_C
MMS1_k127_1532918_3	66692.ABC0564	4.455e-05	53.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,1ZBG8@1386|Bacillus	91061|Bacilli	E	COG0747 ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS1_k127_1532918_4	658086.HMPREF0994_03256	0.0004277	49.0	2A7F2@1|root,30WCJ@2|Bacteria,1USK8@1239|Firmicutes,24ZCK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
MMS1_k127_1532918_0	938293.CAJU020000009_gene1260	4.385e-28	130.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,22I7F@1570339|Peptoniphilaceae	186801|Clostridia	C	FAD binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
MMS1_k127_1532918_2	1469948.JPNB01000001_gene1598	1.338e-05	58.0	COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,36E6A@31979|Clostridiaceae	186801|Clostridia	C	-hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4,Fer4_6
MMS1_k127_1532918_1	658655.HMPREF0988_02073	9.856e-22	98.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1TS6T@1239|Firmicutes,247QK@186801|Clostridia,27KA7@186928|unclassified Lachnospiraceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
MMS1_k127_1533697_7	1089439.KB902272_gene2367	6.391e-38	145.0	COG0778@1|root,COG0778@2|Bacteria,1NSGS@1224|Proteobacteria	1224|Proteobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
MMS1_k127_1533697_8	216594.MMAR_0118	2.169e-24	110.0	COG1309@1|root,COG1309@2|Bacteria,2IHJQ@201174|Actinobacteria,23BMM@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
MMS1_k127_1533697_3	1047013.AQSP01000139_gene2345	4.256e-127	415.0	COG0731@1|root,COG0731@2|Bacteria,2NPIJ@2323|unclassified Bacteria	2|Bacteria	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
MMS1_k127_1533697_5	515635.Dtur_0425	2.036e-65	233.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
MMS1_k127_1533697_2	279010.BL01781	1.981e-134	435.0	COG2040@1|root,COG2040@2|Bacteria,1UHQ5@1239|Firmicutes,4HAS6@91061|Bacilli,1ZC9Q@1386|Bacillus	91061|Bacilli	H	homocysteine	mmuM	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
MMS1_k127_1533697_0	720554.Clocl_3357	0.0	1523.0	COG0493@1|root,COG4624@1|root,COG0493@2|Bacteria,COG4624@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WHYH@541000|Ruminococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
MMS1_k127_1533697_1	1469948.JPNB01000001_gene2371	1.124e-156	499.0	28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,247QF@186801|Clostridia,36EPD@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1533697_4	357809.Cphy_1561	1.891e-65	231.0	COG2186@1|root,COG2186@2|Bacteria,1V5E3@1239|Firmicutes,25BEZ@186801|Clostridia	186801|Clostridia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K03603	-	-	-	-	ko00000,ko03000	-	-	-	GntR
MMS1_k127_1538299_0	913865.DOT_1263	6.788e-118	390.0	COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,2604C@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
MMS1_k127_1538299_1	641107.CDLVIII_5284	9.941e-107	355.0	COG0524@1|root,COG0524@2|Bacteria,1UIWH@1239|Firmicutes,24DTM@186801|Clostridia,36GFR@31979|Clostridiaceae	186801|Clostridia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
MMS1_k127_1538299_2	1173264.KI913949_gene1836	0.0001244	53.0	COG0457@1|root,COG0457@2|Bacteria,1G5VM@1117|Cyanobacteria,1HE7X@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
MMS1_k127_1539717_2	1321778.HMPREF1982_01977	1.703e-59	228.0	COG0457@1|root,COG2199@1|root,COG2203@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,26B8I@186813|unclassified Clostridiales	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,TPR_12,TPR_8
MMS1_k127_1539717_1	706587.Desti_2516	4.843e-64	228.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2MQMZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
MMS1_k127_1539717_3	641491.DND132_1759	4.998e-34	135.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria,2MBWV@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
MMS1_k127_1539717_0	573413.Spirs_3680	7.233e-163	539.0	COG0726@1|root,COG0726@2|Bacteria,2J5Y1@203691|Spirochaetes	203691|Spirochaetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Polysacc_deac_1
MMS1_k127_1542491_0	1123274.KB899408_gene3975	4.046e-183	581.0	COG0438@1|root,COG0438@2|Bacteria,2J6VH@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS1_k127_1542491_1	665571.STHERM_c16620	1.306e-18	92.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.270	ko:K21369	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMS1_k127_1544541_0	545694.TREPR_0173	2.515e-137	448.0	COG2195@1|root,COG2195@2|Bacteria,2J59I@203691|Spirochaetes	203691|Spirochaetes	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
MMS1_k127_1545369_1	573413.Spirs_2277	2.805e-23	110.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF389,FecR
MMS1_k127_1545369_0	744872.Spica_1168	1.429e-176	561.0	COG0166@1|root,COG0166@2|Bacteria,2J5I6@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
MMS1_k127_1549382_2	1121405.dsmv_2608	1.799e-140	455.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	-	-	2.5.1.76,4.2.3.1	ko:K01733,ko:K15527	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
MMS1_k127_1549382_6	1304874.JAFY01000002_gene832	4.577e-66	234.0	COG0834@1|root,COG0834@2|Bacteria,3TC80@508458|Synergistetes	508458|Synergistetes	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_1549382_10	177439.DP0670	2.725e-22	100.0	2CGNP@1|root,32S4A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1549382_3	484770.UFO1_1351	1.231e-112	381.0	COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,4H2AD@909932|Negativicutes	909932|Negativicutes	C	FAD dependent oxidoreductase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
MMS1_k127_1549382_9	1322246.BN4_12420	3.016e-38	164.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2M9XW@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,GGDEF,PAS,PAS_3,PAS_9,dCache_1
MMS1_k127_1549382_5	1294142.CINTURNW_1520	1.884e-73	251.0	COG1309@1|root,COG1309@2|Bacteria,1UYIP@1239|Firmicutes,249K5@186801|Clostridia,36F7M@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
MMS1_k127_1549382_7	1121459.AQXE01000002_gene1245	6.766e-43	180.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2M9XW@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS,PAS_3,PAS_4
MMS1_k127_1549382_1	1280692.AUJL01000016_gene1093	2.519e-319	984.0	COG4716@1|root,COG4716@2|Bacteria,1TQZ6@1239|Firmicutes,248TZ@186801|Clostridia,36EKY@31979|Clostridiaceae	186801|Clostridia	S	Myosin-crossreactive antigen	-	-	4.2.1.53	ko:K10254	-	-	-	-	ko00000,ko01000	-	-	-	MCRA
MMS1_k127_1549382_4	1031288.AXAA01000009_gene722	6.142e-103	339.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,36E69@31979|Clostridiaceae	186801|Clostridia	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
MMS1_k127_1549382_0	1230342.CTM_06806	0.0	1418.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36FQY@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
MMS1_k127_1549382_8	1408422.JHYF01000013_gene589	3.411e-41	155.0	COG0375@1|root,COG0375@2|Bacteria,1V8EK@1239|Firmicutes,25CVT@186801|Clostridia,36JK2@31979|Clostridiaceae	186801|Clostridia	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
MMS1_k127_1549382_11	1408287.AXUR01000025_gene18	4.927e-16	84.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS1_k127_1549382_12	331113.SNE_A19410	6.634e-09	59.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
MMS1_k127_1549413_0	1123274.KB899421_gene1756	7.39e-198	628.0	COG0195@1|root,COG0195@2|Bacteria,2J624@203691|Spirochaetes	203691|Spirochaetes	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1,zf-ribbon_3
MMS1_k127_1549413_1	573413.Spirs_2028	0.0001255	52.0	COG0532@1|root,COG0532@2|Bacteria,2J692@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
MMS1_k127_1552397_0	1333998.M2A_0940	4.127e-113	388.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,4BP86@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
MMS1_k127_1552397_1	1480694.DC28_10070	9.728e-05	45.0	COG0537@1|root,COG0537@2|Bacteria,2J92I@203691|Spirochaetes	203691|Spirochaetes	FG	histidine triad	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMS1_k127_1552917_0	1123274.KB899436_gene1284	1.174e-78	298.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
MMS1_k127_1554918_1	665571.STHERM_c10760	4.752e-48	176.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMS1_k127_1554918_0	1123274.KB899421_gene1815	3.061e-94	318.0	COG1235@1|root,COG1235@2|Bacteria,2J5C5@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMS1_k127_1554918_2	1307761.L21SP2_1769	3.431e-15	82.0	COG1559@1|root,COG1559@2|Bacteria,2J5V4@203691|Spirochaetes	203691|Spirochaetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
MMS1_k127_1555506_0	439235.Dalk_0107	1.932e-119	396.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MJ3D@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
MMS1_k127_1555506_3	767817.Desgi_1018	2.268e-05	54.0	COG1309@1|root,COG1309@2|Bacteria,1V4IA@1239|Firmicutes,247XZ@186801|Clostridia,264ZE@186807|Peptococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1555506_2	1121346.KB899812_gene2094	2.013e-08	63.0	COG1309@1|root,COG1309@2|Bacteria,1TYNZ@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator, TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1555506_1	1232410.KI421422_gene1975	1.118e-97	327.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42MZJ@68525|delta/epsilon subdivisions,2WJK1@28221|Deltaproteobacteria,43UGJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMS1_k127_1557150_2	1123274.KB899410_gene3384	4.581e-100	330.0	COG3968@1|root,COG3968@2|Bacteria,2J5PV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
MMS1_k127_1557150_3	744872.Spica_1647	8.708e-52	184.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
MMS1_k127_1557150_1	665571.STHERM_c13220	8.53e-188	597.0	COG0004@1|root,COG0004@2|Bacteria,2J5W4@203691|Spirochaetes	203691|Spirochaetes	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
MMS1_k127_1557150_0	1480694.DC28_00890	8.761e-193	615.0	COG3604@1|root,COG3604@2|Bacteria,2J5TK@203691|Spirochaetes	203691|Spirochaetes	KT	Fis Family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
MMS1_k127_1557150_4	1121335.Clst_0940	7.89e-39	155.0	COG3884@1|root,COG3884@2|Bacteria,1TRH5@1239|Firmicutes,24G5K@186801|Clostridia,3WRWN@541000|Ruminococcaceae	186801|Clostridia	I	Acyl-ACP thioesterase	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Acyl-ACP_TE
MMS1_k127_1557150_5	1319815.HMPREF0202_01844	3.357e-33	132.0	COG0778@1|root,COG0778@2|Bacteria,37B30@32066|Fusobacteria	32066|Fusobacteria	C	Psort location Cytoplasmic, score 8.96	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
MMS1_k127_1560784_2	28229.ND2E_2236	2.054e-20	99.0	2BXSN@1|root,32R1X@2|Bacteria,1MYVK@1224|Proteobacteria,1S821@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4243)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4243
MMS1_k127_1560784_1	1163409.UUA_00600	9.796e-27	111.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1X2ZJ@135614|Xanthomonadales	135614|Xanthomonadales	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
MMS1_k127_1560784_0	1304284.L21TH_1732	1.333e-76	265.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,36DQZ@31979|Clostridiaceae	186801|Clostridia	J	metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
MMS1_k127_1561378_0	1121396.KB893063_gene1200	3.054e-128	432.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_1561637_0	768710.DesyoDRAFT_3513	0.0	1118.0	COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,260RF@186807|Peptococcaceae	186801|Clostridia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
MMS1_k127_1562268_3	1267534.KB906754_gene3521	1.111e-20	97.0	COG2267@1|root,COG2267@2|Bacteria,3Y77N@57723|Acidobacteria,2JMKZ@204432|Acidobacteriia	204432|Acidobacteriia	I	Serine aminopeptidase, S33	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
MMS1_k127_1562268_2	1167006.UWK_01589	3.668e-29	131.0	COG2199@1|root,COG3437@1|root,COG3437@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	GGDEF,Protoglobin
MMS1_k127_1562268_0	1408473.JHXO01000002_gene4012	6.247e-130	421.0	COG2207@1|root,COG2207@2|Bacteria,4NDYY@976|Bacteroidetes,2FNFA@200643|Bacteroidia	976|Bacteroidetes	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_1562268_1	1196322.A370_04658	6.852e-119	392.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,36EQY@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
MMS1_k127_1562268_4	1282887.AUJG01000029_gene369	8.717e-07	57.0	2EEWJ@1|root,338PW@2|Bacteria,1VXEU@1239|Firmicutes,252HB@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
MMS1_k127_1562268_5	47716.JOFH01000043_gene4049	2.218e-06	51.0	COG2227@1|root,COG2227@2|Bacteria,2GMAR@201174|Actinobacteria	201174|Actinobacteria	H	methyltransferase	-	-	-	ko:K06219	-	-	-	-	ko00000	-	-	-	Methyltransf_25,Methyltransf_31
MMS1_k127_1562542_5	1479237.JMLY01000001_gene1043	2e-09	64.0	COG0642@1|root,COG0834@1|root,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,4667H@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07646,ko:K07679	ko02020,ko05133,map02020,map05133	M00454,M00477	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_1562542_1	1487923.DP73_12155	1.476e-76	269.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,264PV@186807|Peptococcaceae	186801|Clostridia	KT	Response regulator receiver domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,PAS_3,Response_reg
MMS1_k127_1562542_3	889378.Spiaf_1164	1.099e-26	112.0	COG1534@1|root,COG1534@2|Bacteria,2J8BU@203691|Spirochaetes	203691|Spirochaetes	J	PFAM CRS1 YhbY (CRM) domain	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
MMS1_k127_1562542_0	545694.TREPR_2477	8.049e-84	281.0	COG2131@1|root,COG2131@2|Bacteria,2J6UR@203691|Spirochaetes	203691|Spirochaetes	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMS1_k127_1562542_6	877411.JMMA01000002_gene1491	4.765e-06	50.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WGDE@541000|Ruminococcaceae	186801|Clostridia	NU	type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
MMS1_k127_1562542_2	269798.CHU_1240	1.148e-28	129.0	COG0726@1|root,COG3405@1|root,COG0726@2|Bacteria,COG3405@2|Bacteria,4NIN5@976|Bacteroidetes,47MQ6@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolases family 8	-	-	3.2.1.156	ko:K15531	-	-	-	-	ko00000,ko01000	-	GH8	-	CBM9_1,Glyco_hydro_8
MMS1_k127_1562542_4	485918.Cpin_5748	6.845e-14	74.0	COG0726@1|root,COG0726@2|Bacteria,4NE92@976|Bacteroidetes,1IUV7@117747|Sphingobacteriia	976|Bacteroidetes	G	Cellulase N-terminal ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9
MMS1_k127_156259_0	1463825.JNXC01000040_gene5232	2.987e-157	520.0	COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,2GK1D@201174|Actinobacteria,4EABX@85010|Pseudonocardiales	201174|Actinobacteria	M	Insecticide toxin TcdB middle/N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,SpvB,TcdB_toxin_midN
MMS1_k127_1562995_1	573413.Spirs_2070	6.33e-222	714.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2J5YW@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
MMS1_k127_1562995_3	573413.Spirs_3224	3.572e-81	289.0	COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,2J7IJ@203691|Spirochaetes	203691|Spirochaetes	M	HAD-superfamily hydrolase, subfamily IIB	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Hydrolase_3
MMS1_k127_1562995_4	1168034.FH5T_17195	3.673e-52	188.0	COG2050@1|root,COG2050@2|Bacteria,4NRF7@976|Bacteroidetes,2G31E@200643|Bacteroidia	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
MMS1_k127_1562995_6	1358423.N180_03250	7.895e-32	130.0	COG1846@1|root,COG1846@2|Bacteria,4NQNI@976|Bacteroidetes,1IYN2@117747|Sphingobacteriia	976|Bacteroidetes	K	Transcriptional regulator, MarR	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,MarR,MarR_2
MMS1_k127_1562995_2	1121011.AUCB01000013_gene184	2.482e-211	668.0	COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,1HX2V@117743|Flavobacteriia,23FZK@178469|Arenibacter	976|Bacteroidetes	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMS1_k127_1562995_0	1121904.ARBP01000005_gene4787	3.377e-294	909.0	COG2987@1|root,COG2987@2|Bacteria,4NF2P@976|Bacteroidetes,47K5S@768503|Cytophagia	976|Bacteroidetes	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMS1_k127_1562995_5	1392498.JQLH01000001_gene618	2.47e-33	132.0	COG1228@1|root,COG1228@2|Bacteria,4NE6C@976|Bacteroidetes,1HYME@117743|Flavobacteriia,2PG8T@252356|Maribacter	976|Bacteroidetes	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
MMS1_k127_1562995_7	1121904.ARBP01000005_gene4769	3.688e-31	124.0	COG1228@1|root,COG1228@2|Bacteria,4NE6C@976|Bacteroidetes,47K5F@768503|Cytophagia	976|Bacteroidetes	Q	PFAM Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
MMS1_k127_1563558_4	158190.SpiGrapes_0333	0.0005123	43.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	ko:K18555	-	M00729	-	-	ko00000,ko00002,ko01504	-	-	-	Pentapeptide,Pentapeptide_4
MMS1_k127_1563558_1	158190.SpiGrapes_0332	2.208e-45	171.0	COG0491@1|root,COG0491@2|Bacteria,2J7B4@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_1563558_0	906968.Trebr_1302	8.319e-86	294.0	COG0564@1|root,COG0564@2|Bacteria,2J63B@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil	rluD_1	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
MMS1_k127_1563558_3	1125725.HMPREF1325_1571	1.884e-12	74.0	290S3@1|root,34CB1@2|Bacteria,2JBFT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1563558_2	1033733.CAEK01000004_gene1236	2.11e-40	154.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,22H6P@1570339|Peptoniphilaceae	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
MMS1_k127_1564385_3	1219084.AP014508_gene193	5.315e-51	188.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_1564385_4	1219084.AP014508_gene193	3.198e-48	180.0	COG1802@1|root,COG1802@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_1564385_0	748727.CLJU_c28170	7.208e-211	664.0	COG4948@1|root,COG4948@2|Bacteria,1TUWS@1239|Firmicutes,249BH@186801|Clostridia	186801|Clostridia	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS1_k127_1564385_2	1166948.JPZL01000002_gene1748	2.222e-73	259.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
MMS1_k127_1564385_1	158189.SpiBuddy_0722	5.287e-176	565.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
MMS1_k127_1564385_5	742740.HMPREF9474_03393	2.196e-22	99.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24DKH@186801|Clostridia,2204C@1506553|Lachnoclostridium	186801|Clostridia	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_1564928_0	269799.Gmet_2424	3.094e-122	410.0	COG0840@1|root,COG3850@1|root,COG0840@2|Bacteria,COG3850@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,CZB,HAMP,MCPsignal,dCache_1
MMS1_k127_1564928_1	909663.KI867150_gene1123	5.537e-62	225.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,42UVY@68525|delta/epsilon subdivisions,2WR44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
MMS1_k127_1565285_6	1123274.KB899410_gene3557	1.277e-62	227.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
MMS1_k127_1565285_5	391009.Tmel_1735	1.664e-83	289.0	COG0601@1|root,COG0601@2|Bacteria,2GBX3@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS1_k127_1565285_9	1262449.CP6013_0490	4.967e-37	145.0	COG0789@1|root,COG0789@2|Bacteria,1V4UR@1239|Firmicutes,24PV4@186801|Clostridia,36SBE@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
MMS1_k127_1565285_2	886293.Sinac_4372	1.964e-124	413.0	COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
MMS1_k127_1565285_8	1511.CLOST_1319	4.87e-40	152.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia	186801|Clostridia	V	MATE efflux family protein	mepA1	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_1565285_10	1511.CLOST_1320	1.845e-31	128.0	COG1846@1|root,COG1846@2|Bacteria,1VEFZ@1239|Firmicutes,24MSB@186801|Clostridia,25TFF@186804|Peptostreptococcaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS1_k127_1565285_4	573413.Spirs_0365	8.956e-94	327.0	COG0488@1|root,COG0488@2|Bacteria,2J6I5@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
MMS1_k127_1565285_7	1191523.MROS_2196	5.663e-46	181.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1565285_12	1163617.SCD_n00872	1.969e-19	101.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,2VHWT@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	Major facilitator Superfamily	hcaT	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
MMS1_k127_1565285_3	1123228.AUIH01000013_gene211	1.483e-103	349.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
MMS1_k127_1565285_13	332101.JIBU02000014_gene2474	1.229e-15	81.0	COG1695@1|root,COG1695@2|Bacteria,1UYVX@1239|Firmicutes,25B6J@186801|Clostridia,36WCN@31979|Clostridiaceae	186801|Clostridia	K	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
MMS1_k127_1565285_1	1480694.DC28_11525	6.695e-126	410.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS1_k127_1565285_0	1480694.DC28_11520	7.811e-135	435.0	COG1131@1|root,COG1131@2|Bacteria,2JAJ1@203691|Spirochaetes	203691|Spirochaetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_1565285_11	1036674.A28LD_1539	1.897e-26	111.0	COG2267@1|root,COG2267@2|Bacteria,1MZG8@1224|Proteobacteria,1RMW1@1236|Gammaproteobacteria,2QGIN@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
MMS1_k127_1566419_1	865861.AZSU01000001_gene347	3.826e-126	410.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
MMS1_k127_1566419_0	573413.Spirs_2990	1.913e-171	542.0	COG0673@1|root,COG0673@2|Bacteria,2J6J2@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG0673 dehydrogenase and related protein	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1566419_2	1123274.KB899412_gene1396	1.368e-116	384.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1569332_3	1304885.AUEY01000021_gene3451	4.969e-133	433.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,42NDC@68525|delta/epsilon subdivisions,2WJTX@28221|Deltaproteobacteria,2MHVM@213118|Desulfobacterales	28221|Deltaproteobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_1569332_1	1304885.AUEY01000021_gene3450	7.021e-216	685.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria,2MK34@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS1_k127_1569332_0	158189.SpiBuddy_0759	2.026e-266	839.0	COG3533@1|root,COG3533@2|Bacteria,2J76E@203691|Spirochaetes	203691|Spirochaetes	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
MMS1_k127_1569332_4	158189.SpiBuddy_0760	2.528e-130	422.0	COG0395@1|root,COG0395@2|Bacteria,2J7M9@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter (Permease)	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1569332_2	158189.SpiBuddy_0761	2.489e-145	464.0	COG1175@1|root,COG1175@2|Bacteria,2JAFT@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1571629_1	1123274.KB899407_gene222	3.891e-72	263.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
MMS1_k127_1571629_0	1123274.KB899407_gene223	5.103e-148	480.0	COG2114@1|root,COG2203@1|root,COG3829@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	prsK	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_31,CHASE2,GAF_2,GAF_3,Guanylate_cyc,HATPase_c,PAS_4,PAS_9
MMS1_k127_1573947_2	1121289.JHVL01000016_gene708	6.075e-38	145.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,36EF3@31979|Clostridiaceae	186801|Clostridia	P	ABC-type spermidine putrescine transport system, permease component I	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
MMS1_k127_1573947_1	1121324.CLIT_4c00940	8.064e-85	293.0	COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia	186801|Clostridia	P	Abc transporter, permease protein	potC	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
MMS1_k127_1573947_0	1121289.JHVL01000016_gene706	9.818e-111	366.0	COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,36DK4@31979|Clostridiaceae	186801|Clostridia	P	Spermidine putrescine-binding periplasmic protein	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1,SBP_bac_6,SBP_bac_8
MMS1_k127_1574093_3	390236.BafPKo_0324	1.99e-31	136.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	lysM	-	-	-	-	-	-	-	-	-	-	-	LysM
MMS1_k127_1574093_4	906968.Trebr_0558	5.194e-25	117.0	COG0136@1|root,335ZB@2|Bacteria,2J86M@203691|Spirochaetes	203691|Spirochaetes	E	LPP20 lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
MMS1_k127_1574093_1	880073.Calab_2901	1.266e-89	312.0	COG3014@1|root,COG3014@2|Bacteria,2NRCQ@2323|unclassified Bacteria	2|Bacteria	S	protein conserved in bacteria	-	-	-	ko:K09859	-	-	-	-	ko00000	-	-	-	-
MMS1_k127_1574093_2	880073.Calab_2900	1.394e-58	209.0	COG3417@1|root,COG3417@2|Bacteria,2NQZZ@2323|unclassified Bacteria	2|Bacteria	M	Peptidoglycan-synthase activator LpoB	lpoB	GO:0000270,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0019899,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043085,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044093,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	-	ko:K07337,ko:K21008	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	LpoB
MMS1_k127_1574093_0	1321774.HMPREF9108_01237	8.275e-135	437.0	COG0058@1|root,COG0058@2|Bacteria,378HK@32066|Fusobacteria	32066|Fusobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
MMS1_k127_1574849_1	1480694.DC28_10790	1.145e-05	50.0	COG0457@1|root,COG2357@1|root,COG0457@2|Bacteria,COG2357@2|Bacteria,2J6E1@203691|Spirochaetes	203691|Spirochaetes	S	RelA SpoT domain protein	-	-	2.7.6.5	ko:K07816	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	RelA_SpoT,TPR_1,TPR_16,TPR_2,TPR_8
MMS1_k127_1574849_0	537007.BLAHAN_04166	5.121e-112	373.0	COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3XZFW@572511|Blautia	186801|Clostridia	G	Galactokinase galactose-binding signature	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
MMS1_k127_1575180_4	269797.Mbar_A1603	4.144e-58	216.0	COG0644@1|root,arCOG00570@2157|Archaea,2Y2Q7@28890|Euryarchaeota,2NAKJ@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1603	FAD_binding_3
MMS1_k127_1575180_1	642492.Clole_1703	5.891e-116	378.0	COG0822@1|root,COG0822@2|Bacteria,1TQEQ@1239|Firmicutes,248ID@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	NifU_N
MMS1_k127_1575180_0	877414.ATWA01000009_gene2491	1.97e-164	522.0	2C4R5@1|root,2Z7JK@2|Bacteria,1TQIE@1239|Firmicutes,24879@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	GGGtGRT
MMS1_k127_1575180_2	889378.Spiaf_2291	1.36e-94	318.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	metR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016597,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03576	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1575180_3	889378.Spiaf_2186	4.416e-60	219.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
MMS1_k127_1575180_6	1410609.JHVB01000001_gene2004	3.844e-09	68.0	2AM4M@1|root,31BYU@2|Bacteria,2J5QA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1575180_5	1125701.HMPREF1221_00605	1.967e-25	119.0	COG2849@1|root,COG2849@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
MMS1_k127_1575592_3	665571.STHERM_c11120	6.985e-61	220.0	COG0795@1|root,COG0795@2|Bacteria,2J5F9@203691|Spirochaetes	203691|Spirochaetes	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
MMS1_k127_1575592_2	889378.Spiaf_1532	1.91e-90	310.0	COG0795@1|root,COG0795@2|Bacteria,2J64B@203691|Spirochaetes	203691|Spirochaetes	S	Permease, YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
MMS1_k127_1575592_0	665571.STHERM_c11100	6.356e-154	499.0	COG0343@1|root,COG0343@2|Bacteria,2J5U0@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
MMS1_k127_1575592_1	1123274.KB899421_gene1768	1.61e-148	486.0	COG0728@1|root,COG0728@2|Bacteria,2J697@203691|Spirochaetes	203691|Spirochaetes	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
MMS1_k127_1575592_4	889378.Spiaf_1529	4.199e-22	107.0	COG1413@1|root,COG1413@2|Bacteria,2J5WK@203691|Spirochaetes	203691|Spirochaetes	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
MMS1_k127_1576513_1	1379281.AVAG01000032_gene115	2.209e-119	386.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gpgS	-	2.4.1.266,2.4.1.268	ko:K13693,ko:K21349	-	-	-	-	ko00000,ko01000,ko01003	-	GT81	-	Glycos_transf_2
MMS1_k127_1576513_0	1123274.KB899433_gene1330	1.089e-138	452.0	COG0624@1|root,COG0624@2|Bacteria,2J96T@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
MMS1_k127_1576513_2	889378.Spiaf_2436	9.289e-76	260.0	COG0205@1|root,COG0205@2|Bacteria,2J6KH@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
MMS1_k127_1577094_3	314287.GB2207_06683	1.937e-71	258.0	COG0443@1|root,COG0443@2|Bacteria,1MXBT@1224|Proteobacteria,1RN4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the heat shock protein 70 family	yegD	-	-	ko:K04046	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
MMS1_k127_1577094_1	333138.LQ50_14040	3.978e-136	449.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1ZAXK@1386|Bacillus	91061|Bacilli	C	Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively	-	-	-	ko:K22187	ko00040,map00040	-	R11768	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS1_k127_1577094_2	1449126.JQKL01000008_gene261	7.612e-75	261.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia,269QW@186813|unclassified Clostridiales	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1577094_0	889378.Spiaf_0914	2.43e-174	556.0	28HY3@1|root,2Z83I@2|Bacteria	2|Bacteria	S	phosphoenolpyruvate carboxykinase (diphosphate) activity	-	-	4.1.1.38	ko:K20370	ko00620,ko01100,map00620,map01100	-	R00346	RC02741	ko00000,ko00001,ko01000	-	-	-	-
MMS1_k127_1578109_0	1168065.DOK_09601	7.592e-137	441.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RPXG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1578109_3	103733.JNYO01000003_gene8290	3.58e-12	77.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4E6Q9@85010|Pseudonocardiales	201174|Actinobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS1_k127_1578109_1	1320556.AVBP01000013_gene1769	1.02e-95	337.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,2TV1I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS1_k127_1578109_2	358823.DF19_15755	9.027e-18	91.0	COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_1579848_3	1536775.H70737_15980	1.273e-62	233.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,26T2X@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1579848_1	665571.STHERM_c08230	3.705e-85	289.0	COG1349@1|root,COG1349@2|Bacteria,2J5H8@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, DeoR family	-	-	-	ko:K02081,ko:K02436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
MMS1_k127_1579848_0	338966.Ppro_2601	2.617e-211	676.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,43UFT@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
MMS1_k127_1579848_4	313606.M23134_02603	1.325e-44	168.0	COG1846@1|root,COG1846@2|Bacteria,4NQUD@976|Bacteroidetes,47QAI@768503|Cytophagia	976|Bacteroidetes	K	PFAM MarR family	ohrR	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS1_k127_1579848_2	1168034.FH5T_14800	1.004e-65	228.0	COG0386@1|root,COG0386@2|Bacteria,4NM6G@976|Bacteroidetes,2FTA9@200643|Bacteroidia	976|Bacteroidetes	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
MMS1_k127_1579848_5	1321778.HMPREF1982_01692	4.931e-25	109.0	COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia,26CPT@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix, Deoxyribose operon repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
MMS1_k127_1580892_1	443254.Marpi_0374	5.131e-05	46.0	COG0540@1|root,COG1781@1|root,COG0540@2|Bacteria,COG1781@2|Bacteria,2GCQ9@200918|Thermotogae	200918|Thermotogae	F	aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI,PyrI_C
MMS1_k127_1580892_0	243275.TDE_2699	3.438e-64	237.0	COG4372@1|root,COG4372@2|Bacteria,2J5RI@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Borrelia P83 100 protein	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P83
MMS1_k127_1581928_0	103733.JNYO01000008_gene5719	2.209e-50	185.0	COG4832@1|root,COG4832@2|Bacteria,2GN4K@201174|Actinobacteria,4E0H0@85010|Pseudonocardiales	201174|Actinobacteria	K	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
MMS1_k127_1581928_2	1294142.CINTURNW_2411	1.208e-42	166.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1TTBP@1239|Firmicutes,25B7Q@186801|Clostridia,36WJD@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
MMS1_k127_1581928_3	573413.Spirs_3350	2.137e-13	77.0	28X9U@1|root,2ZJ7V@2|Bacteria,2J87S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1581928_1	113395.AXAI01000001_gene3354	9.959e-50	190.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2U33D@28211|Alphaproteobacteria,3JVSE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_1581981_0	1301100.HG529418_gene3010	1.334e-111	373.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,36E4X@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
MMS1_k127_1581981_1	177437.HRM2_39050	6.395e-93	312.0	COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,43AFS@68525|delta/epsilon subdivisions,2X5VJ@28221|Deltaproteobacteria,2MHR9@213118|Desulfobacterales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1582163_2	1235803.C825_04912	1.089e-22	99.0	COG1979@1|root,COG1979@2|Bacteria,4NF1D@976|Bacteroidetes,2FPAW@200643|Bacteroidia,22W7C@171551|Porphyromonadaceae	976|Bacteroidetes	C	alcohol dehydrogenase	yqhD	-	-	ko:K08325	ko00640,map00640	-	R02528	RC00739	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS1_k127_1582163_1	744872.Spica_0134	7.861e-119	387.0	COG0543@1|root,COG0543@2|Bacteria,2J5SH@203691|Spirochaetes	203691|Spirochaetes	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
MMS1_k127_1582163_0	522772.Dacet_0223	3.997e-225	706.0	COG0493@1|root,COG0493@2|Bacteria,2GF1T@200930|Deferribacteres	200930|Deferribacteres	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS1_k127_1582570_1	545694.TREPR_0765	2.234e-50	192.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_1582570_0	1218074.BAXZ01000030_gene4971	4.316e-135	438.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2VI2X@28216|Betaproteobacteria,1K2JP@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
MMS1_k127_1583322_7	573413.Spirs_3655	2.876e-25	111.0	COG4109@1|root,COG4109@2|Bacteria,2J8FH@203691|Spirochaetes	203691|Spirochaetes	K	PFAM DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
MMS1_k127_1583322_1	1268237.G114_07354	1.229e-147	487.0	COG1164@1|root,COG1164@2|Bacteria,1MUYZ@1224|Proteobacteria,1RYXN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Peptidase family M3	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
MMS1_k127_1583322_5	1121405.dsmv_2220	1.106e-63	230.0	COG0042@1|root,COG0042@2|Bacteria,1QDJE@1224|Proteobacteria,42PCR@68525|delta/epsilon subdivisions,2WKBH@28221|Deltaproteobacteria,2MJ5C@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
MMS1_k127_1583322_2	744872.Spica_0367	4.112e-140	453.0	COG4864@1|root,COG4864@2|Bacteria,2J6J6@203691|Spirochaetes	203691|Spirochaetes	S	SigmaW regulon antibacterial	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
MMS1_k127_1583322_3	744872.Spica_0366	4.089e-114	384.0	COG1030@1|root,COG1030@2|Bacteria,2J57R@203691|Spirochaetes	203691|Spirochaetes	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
MMS1_k127_1583322_6	1096546.WYO_1441	2.552e-54	199.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,1JR4K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	PFAM Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
MMS1_k127_1583322_0	401526.TcarDRAFT_2377	3.439e-202	636.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,4H22X@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
MMS1_k127_1583322_4	1304880.JAGB01000002_gene1798	6.609e-76	266.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
MMS1_k127_1587981_0	744872.Spica_0095	6.291e-53	191.0	COG1373@1|root,COG1373@2|Bacteria,2J5MK@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1587981_2	698758.AXY_22860	5.062e-08	56.0	COG1120@1|root,COG1472@1|root,COG1120@2|Bacteria,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1587981_1	882.DVU_0721	4.802e-52	195.0	COG2202@1|root,COG2984@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N6Y@68525|delta/epsilon subdivisions,2WJVA@28221|Deltaproteobacteria,2M8BT@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,NMT1,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1,sCache_2
MMS1_k127_1592042_1	573413.Spirs_2278	1.165e-80	276.0	COG0324@1|root,COG0324@2|Bacteria,2J6T2@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
MMS1_k127_1592042_4	1307761.L21SP2_2419	1.315e-07	56.0	COG1758@1|root,COG1758@2|Bacteria,2JBF9@203691|Spirochaetes	203691|Spirochaetes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
MMS1_k127_1592042_3	889378.Spiaf_2426	5.432e-62	218.0	COG1102@1|root,COG1102@2|Bacteria,2J5P9@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMS1_k127_1592042_2	1480694.DC28_14470	5.764e-80	277.0	COG1561@1|root,COG1561@2|Bacteria,2J76C@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TIGR00255 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
MMS1_k127_1592042_0	596324.TREVI0001_2032	1.596e-157	514.0	COG0773@1|root,COG0773@2|Bacteria,2J5DC@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS1_k127_1593079_0	429009.Adeg_0336	5.075e-233	737.0	COG1614@1|root,COG1614@2|Bacteria,1TSWZ@1239|Firmicutes,248Y2@186801|Clostridia,42EW2@68295|Thermoanaerobacterales	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase complex beta subunit	cdhC	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
MMS1_k127_1593079_1	237368.SCABRO_03345	3.322e-94	320.0	COG1456@1|root,COG1456@2|Bacteria,2J2CN@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,FeS
MMS1_k127_1593550_0	1121447.JONL01000002_gene1988	3.878e-95	323.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X6YR@28221|Deltaproteobacteria,2MH8N@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg,dCache_1
MMS1_k127_1593550_1	1307761.L21SP2_1993	1.811e-61	221.0	2FKMC@1|root,34C8B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1593734_1	573413.Spirs_1347	9.171e-66	229.0	COG2186@1|root,COG2186@2|Bacteria,2J7JW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
MMS1_k127_1593734_0	573413.Spirs_1177	8.728e-108	356.0	COG0524@1|root,COG0524@2|Bacteria,2J6EF@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS1_k127_1593734_3	796620.VIBC2010_17939	3.094e-24	111.0	COG1011@1|root,COG1011@2|Bacteria,1N5XB@1224|Proteobacteria	1224|Proteobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMS1_k127_1593734_5	1408321.JNJD01000007_gene464	1.812e-18	86.0	2BAPB@1|root,32448@2|Bacteria,1UQGX@1239|Firmicutes,24TXP@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1593734_4	204669.Acid345_2504	6.691e-24	114.0	2BMBJ@1|root,32FVP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1593734_2	536232.CLM_0950	1.206e-33	130.0	COG0346@1|root,COG0346@2|Bacteria,1V235@1239|Firmicutes,24G5W@186801|Clostridia,36IEP@31979|Clostridiaceae	186801|Clostridia	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS1_k127_1594305_3	525257.HMPREF0204_11785	1.056e-07	61.0	COG1680@1|root,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,1I7KQ@117743|Flavobacteriia,3ZUB6@59732|Chryseobacterium	976|Bacteroidetes	V	Outer membrane protein SusF_SusE	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,SusF_SusE,TPR_2
MMS1_k127_1594305_1	649638.Trad_1838	1.163e-134	452.0	COG0747@1|root,COG0747@2|Bacteria,1WMAS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS1_k127_1594305_2	489825.LYNGBM3L_28080	7.183e-121	415.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
MMS1_k127_1594305_0	1121939.L861_12725	4.8e-209	670.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XI40@135619|Oceanospirillales	135619|Oceanospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,CHASE5,EAL,GGDEF,PAS_9
MMS1_k127_1594511_1	642492.Clole_3465	4.043e-64	224.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia	186801|Clostridia	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
MMS1_k127_1594511_4	1040982.AXAL01000039_gene129	4.046e-14	80.0	COG0572@1|root,COG0572@2|Bacteria,1Q7X4@1224|Proteobacteria,2VE2Q@28211|Alphaproteobacteria,43QN3@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	uridine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1594511_0	42256.RradSPS_0358	4.036e-135	462.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
MMS1_k127_1594511_6	329726.AM1_6084	4.649e-05	48.0	2DNVA@1|root,32ZBE@2|Bacteria,1GFXX@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1594511_2	573413.Spirs_0076	1.323e-55	207.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
MMS1_k127_1594511_5	568703.LGG_00132	6.479e-10	63.0	COG2159@1|root,COG2159@2|Bacteria,1TRAY@1239|Firmicutes,4HFH2@91061|Bacilli,3F485@33958|Lactobacillaceae	91061|Bacilli	S	Amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
MMS1_k127_1594654_0	158190.SpiGrapes_1238	3.939e-111	364.0	COG1351@1|root,COG1351@2|Bacteria,2J68R@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
MMS1_k127_1594654_1	1480694.DC28_08580	4.146e-60	235.0	COG0457@1|root,COG0457@2|Bacteria,2J58Z@203691|Spirochaetes	203691|Spirochaetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
MMS1_k127_1594841_1	1121430.JMLG01000012_gene1975	1.802e-114	383.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,2601M@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
MMS1_k127_1594841_0	1307437.J139_00650	5.84e-139	467.0	COG5001@1|root,COG5001@2|Bacteria,1MUNI@1224|Proteobacteria,1RRUX@1236|Gammaproteobacteria,2Q0PF@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,EAL,GGDEF,Response_reg
MMS1_k127_1594841_2	404589.Anae109_0959	9.76e-46	178.0	COG2208@1|root,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2Z380@29|Myxococcales	28221|Deltaproteobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2
MMS1_k127_1596340_1	1235800.C819_03165	1.34e-141	460.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,27J28@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolase family 3 C-terminal domain	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1596340_3	936140.AEOT01000020_gene1655	5.424e-64	229.0	COG0657@1|root,COG0657@2|Bacteria,1UZ7B@1239|Firmicutes	1239|Firmicutes	I	Hydrolase, alpha beta domain protein	mlhB	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
MMS1_k127_1596340_2	1226325.HMPREF1548_02393	1.755e-129	432.0	COG2972@1|root,COG2972@2|Bacteria,1UXY6@1239|Firmicutes,24CN6@186801|Clostridia,36FUW@31979|Clostridiaceae	1239|Firmicutes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,His_kinase
MMS1_k127_1596340_4	357809.Cphy_0661	1.68e-35	148.0	COG0657@1|root,COG0657@2|Bacteria,1U1GT@1239|Firmicutes,24E51@186801|Clostridia	186801|Clostridia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
MMS1_k127_1596340_0	1226325.HMPREF1548_02390	7.012e-143	468.0	COG1653@1|root,COG1653@2|Bacteria,1TSF4@1239|Firmicutes,24DIH@186801|Clostridia,36HEB@31979|Clostridiaceae	186801|Clostridia	G	PFAM Bacterial extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
MMS1_k127_1596363_1	744872.Spica_2483	1.197e-44	168.0	2EJFP@1|root,33D6N@2|Bacteria,2J5TW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
MMS1_k127_1596363_2	1123274.KB899427_gene3314	7.712e-15	75.0	2EH2E@1|root,32KRT@2|Bacteria,2J916@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1596363_0	1480694.DC28_10780	1.648e-95	317.0	COG0012@1|root,COG0012@2|Bacteria,2J5RK@203691|Spirochaetes	203691|Spirochaetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
MMS1_k127_1596771_1	1235792.C808_02078	1.399e-85	288.0	COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,24F6M@186801|Clostridia,27K2I@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Putative esterase	-	-	-	ko:K03930	-	-	-	-	ko00000,ko01000	-	CE1	-	Esterase
MMS1_k127_1596771_2	744872.Spica_0624	7.624e-84	289.0	COG1609@1|root,COG1609@2|Bacteria,2J7IG@203691|Spirochaetes	203691|Spirochaetes	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1596771_0	158190.SpiGrapes_1543	2.165e-117	387.0	COG1653@1|root,COG1653@2|Bacteria,2J682@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding	-	-	-	ko:K02027,ko:K17241	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_1598241_1	744872.Spica_1545	7.242e-86	291.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2J5NQ@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
MMS1_k127_1598241_2	1123511.KB905858_gene3833	8.488e-27	123.0	COG0697@1|root,COG0697@2|Bacteria,1UR2H@1239|Firmicutes,4H46C@909932|Negativicutes	909932|Negativicutes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1598241_0	649747.HMPREF0083_05618	2.178e-120	400.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,4HB2U@91061|Bacilli,26S1F@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
MMS1_k127_1600372_5	1307761.L21SP2_0280	2.596e-13	78.0	2F2R9@1|root,33VMJ@2|Bacteria,2J5DF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
MMS1_k127_1600372_2	1123274.KB899412_gene1417	4.435e-143	462.0	COG0502@1|root,COG0502@2|Bacteria,2J61V@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
MMS1_k127_1600372_0	1219375.CM002139_gene331	3.301e-198	625.0	COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales	135614|Xanthomonadales	G	Belongs to the xylose isomerase family	xylA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	-
MMS1_k127_1600372_1	760011.Spico_0155	6.978e-179	575.0	COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_1600372_4	1307761.L21SP2_2527	3.603e-81	278.0	COG4977@1|root,COG4977@2|Bacteria,2J7K1@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
MMS1_k127_1600372_3	1480694.DC28_13335	2.016e-132	431.0	COG4213@1|root,COG4213@2|Bacteria,2J5TP@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
MMS1_k127_1600662_0	573413.Spirs_4114	3.726e-134	443.0	COG4166@1|root,COG4166@2|Bacteria,2J5KU@203691|Spirochaetes	203691|Spirochaetes	E	Bacterial extracellular solute-binding proteins, family 5	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
MMS1_k127_1601177_5	324057.Pjdr2_1991	3.507e-74	260.0	COG1653@1|root,COG1653@2|Bacteria,1TPBS@1239|Firmicutes,4IPRZ@91061|Bacilli,26UKJ@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_1601177_4	1034769.KB910518_gene733	7.596e-86	293.0	COG1175@1|root,COG1175@2|Bacteria,1V0RN@1239|Firmicutes,4IQN5@91061|Bacilli,276FW@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1601177_3	1122917.KB899670_gene4271	1.348e-97	329.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,4HCEH@91061|Bacilli,26VP8@186822|Paenibacillaceae	91061|Bacilli	G	Sugar permease	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1601177_1	1034769.KB910518_gene736	9.21e-162	516.0	COG1331@1|root,COG1331@2|Bacteria,1TQ83@1239|Firmicutes,4HEH5@91061|Bacilli,26S2R@186822|Paenibacillaceae	91061|Bacilli	O	Glycosyl hydrolase	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
MMS1_k127_1601177_0	749414.SBI_01868	5.252e-204	647.0	COG3507@1|root,COG3507@2|Bacteria,2GIW3@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
MMS1_k127_1601177_2	1430440.MGMSRv2_0174	3.997e-147	482.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JPBA@204441|Rhodospirillales	204441|Rhodospirillales	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
MMS1_k127_1601886_0	889378.Spiaf_2452	1.593e-99	342.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,2J5PG@203691|Spirochaetes	203691|Spirochaetes	M	Protein conserved in bacteria	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
MMS1_k127_1618023_0	1284352.AOIG01000011_gene1394	2.959e-61	219.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,4HCEH@91061|Bacilli,274NW@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1618023_1	324057.Pjdr2_1481	5.404e-35	145.0	COG3408@1|root,COG3408@2|Bacteria,1UZDK@1239|Firmicutes,4HF3P@91061|Bacilli,275FP@186822|Paenibacillaceae	91061|Bacilli	G	Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_1623465_1	1278307.KB906974_gene1806	5.656e-69	246.0	COG0642@1|root,COG0834@1|root,COG4251@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QIRM@267894|Psychromonadaceae	1236|Gammaproteobacteria	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	CHASE,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_1623465_0	631362.Thi970DRAFT_04082	1.44e-129	424.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1WWBN@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS1_k127_1623465_2	572544.Ilyop_1526	2.435e-13	72.0	COG0025@1|root,COG1762@1|root,COG0025@2|Bacteria,COG1762@2|Bacteria,37CPG@32066|Fusobacteria	32066|Fusobacteria	GPT	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
MMS1_k127_16236_0	156889.Mmc1_2227	8.726e-130	437.0	COG1220@1|root,COG2202@1|root,COG2203@1|root,COG5001@1|root,COG1220@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9,Response_reg
MMS1_k127_1633089_4	1008457.BAEX01000010_gene1542	2.548e-14	73.0	COG3040@1|root,COG3040@2|Bacteria,4NNFA@976|Bacteroidetes,1I2GH@117743|Flavobacteriia,47I2N@76831|Myroides	976|Bacteroidetes	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
MMS1_k127_1633089_3	1282876.BAOK01000001_gene2769	5.1e-21	102.0	COG2207@1|root,COG2207@2|Bacteria,1N70D@1224|Proteobacteria,2U1QA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_1633089_0	1233950.IW22_05750	2.745e-85	287.0	COG1305@1|root,COG1305@2|Bacteria,4NFI4@976|Bacteroidetes,1HZ26@117743|Flavobacteriia,3ZT90@59732|Chryseobacterium	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
MMS1_k127_1633089_2	1195236.CTER_2871	2.182e-42	171.0	COG4908@1|root,COG4908@2|Bacteria,1TS0H@1239|Firmicutes,24B0M@186801|Clostridia,3WSFR@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Condensation,DUF1298
MMS1_k127_1633089_1	1242864.D187_008565	1.844e-73	254.0	COG3967@1|root,COG3967@2|Bacteria,1QSYJ@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
MMS1_k127_1633089_5	1384049.CD29_15215	1.874e-13	76.0	COG0454@1|root,COG0456@2|Bacteria,1V1RG@1239|Firmicutes,4HFN7@91061|Bacilli,3IY3P@400634|Lysinibacillus	91061|Bacilli	K	GNAT family acetyltransferase	paiA	GO:0003674,GO:0003824,GO:0004145,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0043937,GO:0043939,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0050793,GO:0051093,GO:0065007	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS1_k127_1633122_0	1321779.HMPREF1984_00911	3.665e-51	185.0	COG1373@1|root,COG1373@2|Bacteria,37BX2@32066|Fusobacteria	32066|Fusobacteria	S	K03657 DNA helicase II ATP-dependent DNA helicase PcrA	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1633122_2	1210045.ALNP01000002_gene3967	1.137e-29	137.0	COG0642@1|root,COG1609@1|root,COG2207@1|root,COG1609@2|Bacteria,COG2205@2|Bacteria,COG2207@2|Bacteria,2ICPA@201174|Actinobacteria	201174|Actinobacteria	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Peripla_BP_3,Response_reg
MMS1_k127_1633122_1	1265503.KB905161_gene3352	2.267e-32	145.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1T4AZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
MMS1_k127_1635357_1	1480694.DC28_13025	3.646e-120	392.0	COG0329@1|root,COG0329@2|Bacteria,2J5J6@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS1_k127_1635357_2	665571.STHERM_c08680	2.031e-76	264.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
MMS1_k127_1635357_0	1480694.DC28_13015	1.125e-132	430.0	COG0280@1|root,COG0280@2|Bacteria,2J5DS@203691|Spirochaetes	203691|Spirochaetes	C	phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
MMS1_k127_1635357_3	665571.STHERM_c08700	2.82e-72	251.0	COG0287@1|root,COG0287@2|Bacteria	2|Bacteria	E	prephenate dehydrogenase (NADP+) activity	tyrA	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
MMS1_k127_1635357_4	573413.Spirs_1514	4.629e-28	117.0	COG1664@1|root,COG1664@2|Bacteria,2J861@203691|Spirochaetes	203691|Spirochaetes	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS1_k127_1635357_5	1410609.JHVB01000001_gene2182	1.145e-11	68.0	COG0457@1|root,COG0457@2|Bacteria,2J7IN@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
MMS1_k127_1640055_3	246194.CHY_1870	7.071e-18	87.0	COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia,42GT3@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_1640055_0	1265505.ATUG01000001_gene4799	1.268e-74	276.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42YYK@68525|delta/epsilon subdivisions,2WTQV@28221|Deltaproteobacteria,2MMV7@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Cache_2	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal,dCache_2
MMS1_k127_1640055_1	906968.Trebr_1490	7.045e-71	265.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
MMS1_k127_1640055_2	545694.TREPR_1654	3.926e-46	175.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
MMS1_k127_1641251_3	883.DvMF_2543	1.438e-14	79.0	COG0745@1|root,COG0745@2|Bacteria,1PDU9@1224|Proteobacteria,43EXZ@68525|delta/epsilon subdivisions,2X2IY@28221|Deltaproteobacteria,2MD8C@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS1_k127_1641251_2	880073.Calab_3540	1.029e-28	119.0	COG2204@1|root,COG2204@2|Bacteria,2NRGX@2323|unclassified Bacteria	2|Bacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA,PAS_3,Response_reg
MMS1_k127_1641251_1	332101.JIBU02000014_gene2411	1.05e-87	301.0	COG0618@1|root,COG0618@2|Bacteria,1UKBY@1239|Firmicutes,24EAR@186801|Clostridia,36DMS@31979|Clostridiaceae	186801|Clostridia	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
MMS1_k127_1641251_0	315749.Bcer98_2490	1.029e-88	301.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,4HA4D@91061|Bacilli,1ZB63@1386|Bacillus	91061|Bacilli	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	rbgA	GO:0003674,GO:0003824,GO:0003924,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022613,GO:0042254,GO:0044085,GO:0071840	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
MMS1_k127_1642645_2	573413.Spirs_1389	2.409e-81	276.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS1_k127_1642645_4	926566.Terro_0849	1.735e-56	200.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria	57723|Acidobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS1_k127_1642645_3	298386.PBPRA1939	1.092e-75	263.0	COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,1T26M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Xanthine dehydrogenase	xdhB	GO:0000166,GO:0003674,GO:0003824,GO:0004854,GO:0005488,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009114,GO:0009987,GO:0016491,GO:0016725,GO:0016726,GO:0019439,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046100,GO:0046113,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071949,GO:0072521,GO:0072523,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575	1.17.1.4,1.3.99.8	ko:K13479,ko:K16878	ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120	M00546	R01768,R02103,R02987	RC00143,RC01856	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_2444,iNRG857_1313.NRG857_14070,iS_1188.S3069	CO_deh_flav_C,FAD_binding_5
MMS1_k127_1642645_5	1080067.BAZH01000029_gene1694	4.384e-39	157.0	COG1319@1|root,COG1319@2|Bacteria,1Q59D@1224|Proteobacteria,1RZFY@1236|Gammaproteobacteria,3WVUB@544|Citrobacter	1236|Gammaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	ygfM	-	-	ko:K12529	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS1_k127_1642645_0	573413.Spirs_1394	0.0	1206.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2JA0V@203691|Spirochaetes	203691|Spirochaetes	C	xanthine dehydrogenase, a b hammerhead	-	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
MMS1_k127_1642645_1	1304885.AUEY01000001_gene3145	2.729e-127	423.0	COG1262@1|root,COG1262@2|Bacteria,1R6GS@1224|Proteobacteria,42R3Z@68525|delta/epsilon subdivisions,2WN4D@28221|Deltaproteobacteria,2MJKG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
MMS1_k127_1642645_6	158189.SpiBuddy_0682	3.743e-34	136.0	COG0716@1|root,COG0716@2|Bacteria,2JAHG@203691|Spirochaetes	203691|Spirochaetes	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1642756_1	889378.Spiaf_1825	7.285e-120	394.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
MMS1_k127_1642756_2	642492.Clole_1937	2.454e-63	221.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
MMS1_k127_1642756_0	871968.DESME_06715	3.914e-130	439.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,261B2@186807|Peptococcaceae	186801|Clostridia	KL	DNA helicase, Rad3	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
MMS1_k127_1643858_2	1499967.BAYZ01000090_gene4959	1.161e-90	303.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K00167,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
MMS1_k127_1643858_0	1499967.BAYZ01000090_gene4960	8.447e-174	555.0	COG1249@1|root,COG1249@2|Bacteria,2NNTI@2323|unclassified Bacteria	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS1_k127_1643858_1	760011.Spico_1653	1.042e-132	436.0	COG0508@1|root,COG0508@2|Bacteria,2J686@203691|Spirochaetes	203691|Spirochaetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS1_k127_164535_1	665571.STHERM_c05260	1.257e-70	248.0	COG0606@1|root,COG0606@2|Bacteria,2J59R@203691|Spirochaetes	203691|Spirochaetes	O	magnesium chelatase	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
MMS1_k127_164535_2	877418.ATWV01000018_gene1332	1.458e-51	187.0	COG0328@1|root,COG0328@2|Bacteria,2J7Y2@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
MMS1_k127_164535_3	1307761.L21SP2_1266	6.201e-41	157.0	COG2176@1|root,COG2176@2|Bacteria,2JBJN@203691|Spirochaetes	203691|Spirochaetes	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
MMS1_k127_164535_0	1307761.L21SP2_1264	5.633e-75	258.0	COG1109@1|root,COG1109@2|Bacteria,2J5QI@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	cpsG	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS1_k127_1647934_0	1307761.L21SP2_2078	5.538e-197	625.0	COG3666@1|root,COG3666@2|Bacteria,2J98U@203691|Spirochaetes	203691|Spirochaetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
MMS1_k127_1650775_1	1031288.AXAA01000002_gene1409	2.956e-198	632.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
MMS1_k127_1650775_0	1121403.AUCV01000001_gene734	1.133e-206	651.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2MHP6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase, FAD NAD(P)-binding domain, pyridine nucleotide-disulfide oxidoreductase dimerization region, FAD-dependent pyridine nucleotide-disulfide oxidoreductase	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS1_k127_1650775_2	1121403.AUCV01000001_gene735	2.522e-69	238.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2MN1G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS1_k127_165228_0	573413.Spirs_4053	1.01e-109	375.0	COG5000@1|root,COG5000@2|Bacteria,2J753@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_1652892_3	1274374.CBLK010000079_gene3984	1.318e-85	289.0	COG2972@1|root,COG2972@2|Bacteria,1TQZM@1239|Firmicutes,4I6FM@91061|Bacilli,26STD@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
MMS1_k127_1652892_0	1274374.CBLK010000079_gene3985	7.269e-157	511.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TPDP@1239|Firmicutes,4I6S7@91061|Bacilli,26UNB@186822|Paenibacillaceae	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_1652892_1	657322.FPR_25250	1.593e-92	314.0	2DBRG@1|root,2ZAKM@2|Bacteria,1UQ8F@1239|Firmicutes,24CHJ@186801|Clostridia,3WN9M@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1652892_2	742738.HMPREF9460_02608	5.98e-88	298.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,267YM@186813|unclassified Clostridiales	186801|Clostridia	H	Bacterial lipoate protein ligase C-terminus	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
MMS1_k127_1653053_1	1536773.R70331_07055	2.096e-58	206.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,26UYP@186822|Paenibacillaceae	91061|Bacilli	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_1653053_2	1536773.R70331_07060	4.6e-53	199.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H9Y3@91061|Bacilli,26VZC@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_1653053_3	632292.Calhy_2345	3.809e-42	170.0	COG1609@1|root,COG1609@2|Bacteria,1UZFZ@1239|Firmicutes,24H13@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1653053_0	632292.Calhy_2344	1.9e-63	231.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes,24PGN@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_165349_3	866536.Belba_3129	4.792e-10	65.0	COG1309@1|root,COG1309@2|Bacteria,4NHIJ@976|Bacteroidetes,47K37@768503|Cytophagia	976|Bacteroidetes	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_165349_2	545694.TREPR_0549	5.543e-75	264.0	COG0845@1|root,COG0845@2|Bacteria,2J88F@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
MMS1_k127_165349_0	545694.TREPR_0547	9.637e-269	859.0	COG0841@1|root,COG0841@2|Bacteria,2J6SF@203691|Spirochaetes	203691|Spirochaetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_165349_1	1094980.Mpsy_0332	1.616e-169	540.0	COG0019@1|root,arCOG02268@2157|Archaea,2XYK2@28890|Euryarchaeota,2N9RB@224756|Methanomicrobia	224756|Methanomicrobia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2177	Orn_Arg_deC_N,Orn_DAP_Arg_deC
MMS1_k127_1655959_0	1123274.KB899424_gene2999	7.013e-40	166.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1657447_1	1121440.AUMA01000010_gene363	3.075e-26	115.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKYI@28221|Deltaproteobacteria,2MA7Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	response regulator, receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
MMS1_k127_1657447_2	1144313.PMI10_01364	6.11e-19	99.0	COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NI8Z@976|Bacteroidetes,1HZHS@117743|Flavobacteriia,2NTF0@237|Flavobacterium	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_12,TPR_7,TPR_8
MMS1_k127_1657447_3	1123274.KB899423_gene1612	1.359e-13	79.0	COG3275@1|root,COG3275@2|Bacteria,2JAV0@203691|Spirochaetes	203691|Spirochaetes	T	ECF-type riboflavin transporter, S component	-	-	-	ko:K16923	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.28	-	-	ECF-ribofla_trS,ECF_trnsprt
MMS1_k127_1657447_0	1123274.KB899433_gene1338	4.45e-76	258.0	COG2316@1|root,COG2316@2|Bacteria,2J7SZ@203691|Spirochaetes	203691|Spirochaetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
MMS1_k127_1658864_2	292563.Cyast_0752	5.801e-41	165.0	COG3188@1|root,COG3188@2|Bacteria,1G1BM@1117|Cyanobacteria	1117|Cyanobacteria	NU	COGs COG3188 P pilus assembly protein porin PapC	-	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	Usher
MMS1_k127_1658864_1	1480694.DC28_13530	5.53e-45	175.0	COG5430@1|root,COG5430@2|Bacteria	2|Bacteria	S	Spore Coat Protein U domain	-	-	-	-	-	-	-	-	-	-	-	-	SCPU
MMS1_k127_1658864_0	1168034.FH5T_06895	2.886e-47	173.0	COG0820@1|root,COG0820@2|Bacteria,4NFH5@976|Bacteroidetes,2FPJH@200643|Bacteroidia	976|Bacteroidetes	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
MMS1_k127_1658890_0	1313304.CALK_1971	1.85e-98	330.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria	2|Bacteria	C	pyruvate	oadA	-	2.1.3.1,2.3.1.12,4.1.1.3,6.4.1.1,6.4.1.7	ko:K00627,ko:K01571,ko:K01960,ko:K02160,ko:K03416,ko:K20140	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00307,M00376,M00620	R00209,R00217,R00344,R00353,R00742,R00930,R02569	RC00004,RC00040,RC00097,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	iJN746.PP_5346	Biotin_lipoyl,HMGL-like,PYC_OADA
MMS1_k127_1658890_1	941449.dsx2_0990	3.026e-26	113.0	2BIEA@1|root,32CKM@2|Bacteria,1PZIM@1224|Proteobacteria,435ZZ@68525|delta/epsilon subdivisions,2X0HF@28221|Deltaproteobacteria,2MCBW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
MMS1_k127_1661031_1	1499967.BAYZ01000041_gene2336	5.827e-35	136.0	COG1811@1|root,COG1811@2|Bacteria,2NPEK@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF554)	ydfK	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
MMS1_k127_1661031_2	666686.B1NLA3E_22065	1.34e-34	138.0	COG3697@1|root,COG3697@2|Bacteria,1VB3E@1239|Firmicutes,4HMN1@91061|Bacilli	91061|Bacilli	HI	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)	citX	-	2.7.7.61	ko:K05964	ko02020,map02020	-	R10706	-	ko00000,ko00001,ko01000	-	-	-	CitX
MMS1_k127_1661031_0	243275.TDE_0690	6.814e-82	284.0	COG0482@1|root,COG0482@2|Bacteria,2J6BI@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
MMS1_k127_1663611_1	744872.Spica_0727	2.02e-41	154.0	COG0395@1|root,COG0395@2|Bacteria,2J65P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10190	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	BPD_transp_1
MMS1_k127_1663611_0	1121346.KB899822_gene2907	1.002e-224	718.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,4HARI@91061|Bacilli,26SRJ@186822|Paenibacillaceae	91061|Bacilli	G	beta-galactosidase	lacA	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
MMS1_k127_1663611_2	635013.TherJR_1645	3.38e-33	132.0	COG0494@1|root,COG0494@2|Bacteria,1V6ET@1239|Firmicutes,25EBI@186801|Clostridia,267A9@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
MMS1_k127_1663611_3	497965.Cyan7822_2028	7.621e-16	82.0	COG0840@1|root,COG0840@2|Bacteria,1GEWT@1117|Cyanobacteria,3KJ4U@43988|Cyanothece	1117|Cyanobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1666467_3	889378.Spiaf_1779	2.171e-40	153.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_1666467_1	158190.SpiGrapes_2916	4.211e-57	221.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2J5MA@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
MMS1_k127_1666467_0	1307761.L21SP2_0315	2.358e-57	216.0	COG4591@1|root,COG4591@2|Bacteria,2J6KF@203691|Spirochaetes	203691|Spirochaetes	M	ABC transporter permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_1666467_2	1307761.L21SP2_0316	1.762e-45	176.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_1666467_4	1307761.L21SP2_0317	2.059e-27	120.0	2DNEA@1|root,32X2Y@2|Bacteria,2J767@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1669125_1	889378.Spiaf_0993	7.977e-48	176.0	COG0500@1|root,COG2226@2|Bacteria,2J9BW@203691|Spirochaetes	203691|Spirochaetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS1_k127_1669125_0	1322246.BN4_20209	1.388e-62	223.0	COG0745@1|root,COG0745@2|Bacteria,1Q2S0@1224|Proteobacteria,42S32@68525|delta/epsilon subdivisions,2X627@28221|Deltaproteobacteria,2MH17@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1669125_3	864051.BurJ1DRAFT_3822	4.665e-42	171.0	COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MUAK@1224|Proteobacteria,2VIS3@28216|Betaproteobacteria,1KJD7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_1669125_2	398512.JQKC01000006_gene791	1.385e-44	173.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,3WIYS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
MMS1_k127_1671976_2	82654.Pse7367_2389	0.0001178	46.0	COG0484@1|root,COG0484@2|Bacteria,1G5UK@1117|Cyanobacteria,1H9H6@1150|Oscillatoriales	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_2
MMS1_k127_1671976_1	1307761.L21SP2_2347	8.009e-49	180.0	2C5UX@1|root,33TSC@2|Bacteria,2J5VA@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1671976_0	889378.Spiaf_0162	4.782e-74	260.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
MMS1_k127_1673214_3	1307761.L21SP2_0776	4.095e-22	112.0	COG2703@1|root,COG2703@2|Bacteria,2J7CC@203691|Spirochaetes	203691|Spirochaetes	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
MMS1_k127_1673214_0	1307761.L21SP2_0775	7.333e-71	263.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406,ko:K07216	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,Hemerythrin,MCPsignal,dCache_1
MMS1_k127_1673214_1	742733.HMPREF9469_03784	1.39e-64	230.0	COG0395@1|root,COG0395@2|Bacteria,1TT5G@1239|Firmicutes,249MU@186801|Clostridia,222DE@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17236	ko02010,map02010	M00602	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.34	-	-	BPD_transp_1
MMS1_k127_1673214_2	1122147.AUEH01000005_gene876	1.831e-58	213.0	COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,4HCD0@91061|Bacilli,3F464@33958|Lactobacillaceae	91061|Bacilli	P	ABC-type sugar transport systems, permease components	-	-	-	ko:K10121	-	M00197	-	-	ko00000,ko00002,ko02000	3.A.1.1.20	-	-	BPD_transp_1
MMS1_k127_1673928_1	722419.PH505_dm00030	1.734e-08	63.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2Q1JG@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_9,dCache_1
MMS1_k127_1673928_0	744872.Spica_1646	7.062e-231	726.0	COG3968@1|root,COG3968@2|Bacteria,2J5PV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
MMS1_k127_1683149_1	484770.UFO1_1323	1.123e-25	113.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4H43P@909932|Negativicutes	909932|Negativicutes	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_1683149_0	180332.JTGN01000003_gene2142	2.141e-118	388.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_1686185_2	1094508.Tsac_2301	9.926e-95	323.0	COG3387@1|root,COG3387@2|Bacteria,1TR12@1239|Firmicutes,248Q3@186801|Clostridia	186801|Clostridia	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
MMS1_k127_1686185_0	1380763.BG53_01350	7.577e-189	616.0	COG1501@1|root,COG3387@1|root,COG1501@2|Bacteria,COG3387@2|Bacteria,1TR8N@1239|Firmicutes,4HB1D@91061|Bacilli,26V14@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolases family 31	-	-	-	-	-	-	-	-	-	-	-	-	Gal_mutarotas_2,Glyco_hydro_31
MMS1_k127_1686185_1	1385511.N783_18665	1.614e-132	434.0	COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,4H9MG@91061|Bacilli,2YBH4@289201|Pontibacillus	91061|Bacilli	G	Sugar ABC transporter substrate-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_1686185_3	683837.lse_0157	2.533e-88	299.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,26J9V@186820|Listeriaceae	91061|Bacilli	P	ABC transporter (permease)	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1686185_4	1385511.N783_18655	8.498e-48	174.0	COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,4HBEF@91061|Bacilli,2YAFJ@289201|Pontibacillus	91061|Bacilli	U	ABC transporter	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1686544_0	1480694.DC28_06740	1.227e-107	351.0	COG1117@1|root,COG1117@2|Bacteria,2J6DF@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS1_k127_1686544_1	1307761.L21SP2_0914	1.508e-52	193.0	COG0704@1|root,COG0704@2|Bacteria,2J8BS@203691|Spirochaetes	203691|Spirochaetes	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
MMS1_k127_1686544_2	362418.IW19_11755	0.0001139	55.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia,2NTCP@237|Flavobacterium	976|Bacteroidetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
MMS1_k127_1687245_3	1123274.KB899409_gene477	9.598e-31	129.0	2EUFF@1|root,33MXQ@2|Bacteria,2J8XM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	LPP20
MMS1_k127_1687245_1	1123274.KB899410_gene3387	5.503e-49	190.0	COG3712@1|root,COG3712@2|Bacteria	2|Bacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	DUF4974,FecR
MMS1_k127_1687245_2	1499967.BAYZ01000076_gene841	1.317e-43	171.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
MMS1_k127_1687245_0	1307761.L21SP2_2976	3.993e-64	222.0	COG0012@1|root,COG0012@2|Bacteria,2J5RK@203691|Spirochaetes	203691|Spirochaetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
MMS1_k127_1689320_1	484770.UFO1_1322	6.398e-148	479.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,4H2YS@909932|Negativicutes	909932|Negativicutes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
MMS1_k127_1689320_2	484770.UFO1_1323	4.889e-90	301.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4H43P@909932|Negativicutes	909932|Negativicutes	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_1689320_0	484770.UFO1_1324	6.054e-172	550.0	COG1653@1|root,COG1653@2|Bacteria,1TPX9@1239|Firmicutes,4H3SU@909932|Negativicutes	909932|Negativicutes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_1689320_3	887325.HMPREF0381_0746	4.642e-11	66.0	COG1879@1|root,COG1879@2|Bacteria,1V0B8@1239|Firmicutes,25BI8@186801|Clostridia,1HUGH@1164882|Lachnoanaerobaculum	186801|Clostridia	G	Periplasmic binding protein-like domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1692340_1	218284.CCDN010000001_gene500	1.256e-24	111.0	COG3173@1|root,COG3173@2|Bacteria,1VIJ4@1239|Firmicutes,4HQI2@91061|Bacilli,1ZQ71@1386|Bacillus	91061|Bacilli	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMS1_k127_1692340_0	1120705.FG95_01036	1.46e-30	128.0	COG1073@1|root,COG1073@2|Bacteria,1R2CS@1224|Proteobacteria,2TZHJ@28211|Alphaproteobacteria,2KBAC@204457|Sphingomonadales	204457|Sphingomonadales	S	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1699058_0	935836.JAEL01000012_gene5097	8.568e-33	137.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2BS@1239|Firmicutes,4IT2U@91061|Bacilli,1ZGS3@1386|Bacillus	91061|Bacilli	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1699058_1	189425.PGRAT_13610	1.191e-17	85.0	COG2972@1|root,COG2972@2|Bacteria,1UCQF@1239|Firmicutes,4HEAY@91061|Bacilli,26QNI@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase
MMS1_k127_1700002_0	1265505.ATUG01000002_gene2236	1.54e-88	307.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2MIVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
MMS1_k127_1700002_1	926549.KI421517_gene2581	3.716e-33	135.0	COG2996@1|root,COG2996@2|Bacteria,4NGS6@976|Bacteroidetes,47KDR@768503|Cytophagia	976|Bacteroidetes	S	S1 domain	yitL	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
MMS1_k127_1701598_1	641107.CDLVIII_2917	6.183e-129	418.0	COG1028@1|root,COG1028@2|Bacteria,1TRQB@1239|Firmicutes,24NWD@186801|Clostridia,36H3G@31979|Clostridiaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_1701598_2	641107.CDLVIII_2916	8.52e-77	261.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
MMS1_k127_1701598_0	1123274.KB899406_gene1079	9.842e-130	419.0	COG3588@1|root,COG3588@2|Bacteria,2J75R@203691|Spirochaetes	203691|Spirochaetes	G	fructose-bisphosphate aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
MMS1_k127_1701598_3	744872.Spica_1005	1.184e-41	163.0	2C73B@1|root,330Z7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS1_k127_1703036_0	857087.Metme_1847	2.129e-79	269.0	COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,1RPM8@1236|Gammaproteobacteria,1XGYB@135618|Methylococcales	135618|Methylococcales	U	PFAM Multiple antibiotic resistance (MarC)-related	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS1_k127_1703767_1	555500.I215_15275	1.101e-12	81.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia	976|Bacteroidetes	K	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
MMS1_k127_1703767_0	1123274.KB899436_gene1284	3.374e-16	85.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
MMS1_k127_1704685_1	665571.STHERM_c05940	7.202e-62	216.0	COG0787@1|root,COG0787@2|Bacteria,2J5JY@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
MMS1_k127_1704685_3	671143.DAMO_0814	2.125e-27	115.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
MMS1_k127_1704685_5	889378.Spiaf_0395	8.382e-11	65.0	2EC1X@1|root,33GB5@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
MMS1_k127_1704685_4	1191523.MROS_0533	1.284e-15	81.0	COG0792@1|root,COG0792@2|Bacteria	2|Bacteria	L	nuclease activity	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
MMS1_k127_1704685_0	1128421.JAGA01000002_gene732	3.312e-157	512.0	COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria	2|Bacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K06400,ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
MMS1_k127_1704685_2	697281.Mahau_0843	6.117e-37	150.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,42FQZ@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
MMS1_k127_1709585_1	1307761.L21SP2_2683	3.92e-90	312.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1,MFS_2,PTS_EIIA_1
MMS1_k127_1709585_2	880071.Fleli_2187	1.595e-89	301.0	COG0177@1|root,COG0177@2|Bacteria,4NFF3@976|Bacteroidetes,47JCH@768503|Cytophagia	976|Bacteroidetes	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
MMS1_k127_1709585_6	1511.CLOST_0022	8.66e-20	96.0	COG1309@1|root,COG1309@2|Bacteria,1V8M2@1239|Firmicutes,25AZQ@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1709585_3	1480694.DC28_12565	7.242e-86	291.0	COG1108@1|root,COG1108@2|Bacteria,2J6GM@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1108 ABC-type Mn2 Zn2 transport systems permease components	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
MMS1_k127_1709585_0	1307761.L21SP2_2459	3.276e-112	368.0	COG1121@1|root,COG1121@2|Bacteria,2J6HR@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter	znuC	-	-	ko:K09817,ko:K11607,ko:K11710	ko02010,map02010	M00242,M00317,M00319	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5,3.A.1.15.7,3.A.1.15.9	-	-	ABC_tran
MMS1_k127_1709585_5	926569.ANT_20960	3.656e-50	190.0	COG0803@1|root,COG0803@2|Bacteria,2G6XK@200795|Chloroflexi	200795|Chloroflexi	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
MMS1_k127_1709585_4	1449050.JNLE01000003_gene2483	2.608e-55	201.0	COG1309@1|root,COG1309@2|Bacteria,1VKSB@1239|Firmicutes,24TVD@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1709585_7	1410609.JHVB01000010_gene2417	0.000945	43.0	COG2199@1|root,COG3706@2|Bacteria,2J5A2@203691|Spirochaetes	203691|Spirochaetes	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_1710712_3	1303518.CCALI_01446	6.858e-09	67.0	COG5616@1|root,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	bamA	-	-	ko:K03765,ko:K07277	-	-	-	-	ko00000,ko02000,ko03000,ko03029	1.B.33	-	-	Bac_surface_Ag,CsgG,POTRA,VCBS
MMS1_k127_1710712_1	1033810.HLPCO_001911	1.3e-62	225.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1710712_0	573413.Spirs_3959	9.865e-102	348.0	2A76W@1|root,30W2Y@2|Bacteria,2JADI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1710712_2	1307761.L21SP2_3386	6.09e-28	119.0	COG1472@1|root,COG1472@2|Bacteria,2J60D@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1711460_5	243231.GSU0516	2.898e-11	73.0	COG1082@1|root,COG1082@2|Bacteria,1RGEK@1224|Proteobacteria,42S9K@68525|delta/epsilon subdivisions,2WNFH@28221|Deltaproteobacteria,43TC8@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMS1_k127_1711460_0	313628.LNTAR_10606	9.329e-159	512.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
MMS1_k127_1711460_2	929556.Solca_3505	2.107e-94	323.0	COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,1INTU@117747|Sphingobacteriia	976|Bacteroidetes	J	PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
MMS1_k127_1711460_3	177437.HRM2_20440	4.431e-64	233.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42NWQ@68525|delta/epsilon subdivisions,2WM5R@28221|Deltaproteobacteria,2MJ8Y@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,PAS,PAS_4
MMS1_k127_1711460_1	889378.Spiaf_2412	3.545e-136	442.0	COG2357@1|root,COG2357@2|Bacteria	2|Bacteria	S	guanosine tetraphosphate metabolic process	-	-	2.7.6.5	ko:K00951,ko:K07816	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	RelA_SpoT
MMS1_k127_1711460_4	1123242.JH636434_gene3630	2.5e-22	108.0	COG0164@1|root,COG0164@2|Bacteria,2J4X4@203682|Planctomycetes	203682|Planctomycetes	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1711695_1	572547.Amico_1496	8.363e-10	60.0	COG1132@1|root,COG1132@2|Bacteria,3TAG9@508458|Synergistetes	508458|Synergistetes	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
MMS1_k127_1711695_0	177437.HRM2_24170	2.156e-88	309.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG4564@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4564@2|Bacteria,1RCM9@1224|Proteobacteria,42PJE@68525|delta/epsilon subdivisions,2WKQ8@28221|Deltaproteobacteria,2MPRP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Cache_2	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg,dCache_2
MMS1_k127_1712376_2	1280668.ATVT01000005_gene1937	7.438e-09	57.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TT52@1239|Firmicutes,249A9@186801|Clostridia,4BZKF@830|Butyrivibrio	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_1712376_0	743719.PaelaDRAFT_1264	9.632e-135	449.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,4HBSD@91061|Bacilli,274CP@186822|Paenibacillaceae	91061|Bacilli	T	Cache domain	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
MMS1_k127_1712376_1	324057.Pjdr2_5330	1.698e-61	222.0	COG1879@1|root,COG1879@2|Bacteria,1TPWA@1239|Firmicutes,4IPVE@91061|Bacilli,2764Q@186822|Paenibacillaceae	91061|Bacilli	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1712518_9	305900.GV64_19445	3.817e-71	249.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_1712518_21	261292.Nit79A3_3497	4.075e-07	55.0	2DRAI@1|root,33AYP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1712518_5	373994.Riv7116_3206	1.458e-122	407.0	COG0534@1|root,COG0534@2|Bacteria,1G2M4@1117|Cyanobacteria,1HQ3N@1161|Nostocales	1117|Cyanobacteria	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
MMS1_k127_1712518_14	1123274.KB899427_gene3350	3.957e-47	173.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
MMS1_k127_1712518_12	1123274.KB899427_gene3351	4.836e-55	197.0	COG0589@1|root,COG0589@2|Bacteria,2J7EV@203691|Spirochaetes	203691|Spirochaetes	T	universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS1_k127_1712518_8	760011.Spico_0755	3.412e-76	260.0	COG1394@1|root,COG1394@2|Bacteria,2J5V1@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS1_k127_1712518_0	573413.Spirs_3107	1.161e-244	762.0	COG1156@1|root,COG1156@2|Bacteria,2J5SP@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_1712518_2	1232410.KI421413_gene553	1.118e-223	708.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,42NKK@68525|delta/epsilon subdivisions,2WIQQ@28221|Deltaproteobacteria,43UIJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS1_k127_1712518_19	158190.SpiGrapes_0739	7.887e-12	73.0	COG1390@1|root,COG1390@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
MMS1_k127_1712518_16	760011.Spico_0759	3.087e-31	125.0	COG1436@1|root,COG1436@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMS1_k127_1712518_18	760011.Spico_0760	2.812e-26	111.0	COG0636@1|root,COG0636@2|Bacteria,2J8ME@203691|Spirochaetes	203691|Spirochaetes	P	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS1_k127_1712518_3	158190.SpiGrapes_0742	2.02e-169	559.0	COG1269@1|root,COG1269@2|Bacteria,2J6DX@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS1_k127_1712518_11	158189.SpiBuddy_1143	1.032e-61	227.0	COG1527@1|root,COG1527@2|Bacteria,2JADK@203691|Spirochaetes	203691|Spirochaetes	C	PFAM ATP synthase (C AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMS1_k127_1712518_10	561231.Pecwa_1287	1.154e-63	228.0	28PCP@1|root,2ZC4Z@2|Bacteria,1R9YH@1224|Proteobacteria,1S2ZC@1236|Gammaproteobacteria,1MQW6@122277|Pectobacterium	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1712518_22	1487953.JMKF01000053_gene1718	6.976e-05	50.0	COG1487@1|root,COG1487@2|Bacteria,1G6K5@1117|Cyanobacteria,1HC63@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
MMS1_k127_1712518_1	671143.DAMO_2383	3.55e-239	747.0	COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufB	sufB	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078	UPF0051
MMS1_k127_1712518_7	471874.PROSTU_02287	2.036e-97	328.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,3Z8I7@586|Providencia	1236|Gammaproteobacteria	O	COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710	ABC_tran
MMS1_k127_1712518_13	661478.OP10G_0547	4.764e-50	194.0	COG0719@1|root,COG0719@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
MMS1_k127_1712518_4	1278073.MYSTI_01204	2.463e-147	476.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PJT@68525|delta/epsilon subdivisions,2WKPW@28221|Deltaproteobacteria,2YXCR@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS1_k127_1712518_15	1038869.AXAN01000012_gene6394	2.271e-46	171.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ3A@28216|Betaproteobacteria,1K7JP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMS1_k127_1712518_20	1128421.JAGA01000002_gene1798	5.321e-11	68.0	COG2151@1|root,COG2151@2|Bacteria,2NPUI@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF59	yitW	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
MMS1_k127_1712518_6	1265505.ATUG01000003_gene788	1.061e-117	392.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_1712518_17	1265505.ATUG01000001_gene4499	1.513e-27	117.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_1713526_1	889378.Spiaf_0601	1.74e-36	145.0	COG1536@1|root,COG1536@2|Bacteria,2J6EK@203691|Spirochaetes	203691|Spirochaetes	N	flagellar motor switch protein	fliG-1	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
MMS1_k127_1713526_0	1123274.KB899429_gene2872	1.041e-243	761.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS1_k127_171409_4	742733.HMPREF9469_01098	4.59e-19	99.0	COG1879@1|root,COG1879@2|Bacteria,1UJV6@1239|Firmicutes,25FAT@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
MMS1_k127_171409_3	887325.HMPREF0381_2750	6.632e-38	155.0	COG1172@1|root,COG1172@2|Bacteria,1TRVC@1239|Firmicutes,24DSG@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_171409_0	319795.Dgeo_2783	2.275e-263	842.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_171409_2	743722.Sph21_4324	1.78e-118	401.0	COG2272@1|root,COG2272@2|Bacteria,4NI40@976|Bacteroidetes	976|Bacteroidetes	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
MMS1_k127_171409_1	861454.HMPREF9099_00198	1.228e-156	516.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,27I89@186928|unclassified Lachnospiraceae	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
MMS1_k127_171409_5	1499684.CCNP01000018_gene1308	1.455e-14	82.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TS6T@1239|Firmicutes,247QK@186801|Clostridia,36IQ0@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
MMS1_k127_1720047_0	1313304.CALK_2444	9.742e-241	749.0	28I0T@1|root,2Z85H@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4914
MMS1_k127_1720047_1	1280696.ATVY01000009_gene3100	0.000404	47.0	COG1846@1|root,COG1846@2|Bacteria,1V6UN@1239|Firmicutes,24JGS@186801|Clostridia,4BZ6S@830|Butyrivibrio	186801|Clostridia	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR
MMS1_k127_1723424_3	1173028.ANKO01000078_gene3903	2.46e-28	133.0	COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales	1117|Cyanobacteria	KLT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,PAS_3,Pkinase,Response_reg
MMS1_k127_1723424_0	1265505.ATUG01000001_gene3051	3.66e-123	422.0	COG2203@1|root,COG2984@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WMWW@28221|Deltaproteobacteria,2MMSG@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9
MMS1_k127_1723424_2	744872.Spica_0151	3.533e-44	176.0	COG4585@1|root,COG4585@2|Bacteria,2J7E5@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
MMS1_k127_1723424_1	889378.Spiaf_0950	2.209e-62	222.0	COG2197@1|root,COG2197@2|Bacteria,2J7CS@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_1724220_0	1122915.AUGY01000088_gene5267	2.509e-231	735.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,4HARI@91061|Bacilli,26U20@186822|Paenibacillaceae	91061|Bacilli	G	Cellulase (glycosyl hydrolase family 5)	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42M
MMS1_k127_1724220_1	1449050.JNLE01000003_gene1981	1.414e-198	628.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,36EF9@31979|Clostridiaceae	186801|Clostridia	G	Beta-galactosidase trimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
MMS1_k127_1724220_2	1232437.KL661971_gene4895	8.589e-09	59.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,42Q8R@68525|delta/epsilon subdivisions,2WMDK@28221|Deltaproteobacteria,2MJEG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
MMS1_k127_1725153_3	1121939.L861_03715	2.829e-06	55.0	COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,1T1XV@1236|Gammaproteobacteria,1XJ40@135619|Oceanospirillales	135619|Oceanospirillales	T	Histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,sCache_2
MMS1_k127_1725153_2	1279009.ADICEAN_01036	4.17e-33	135.0	COG1309@1|root,COG1309@2|Bacteria,4NFR4@976|Bacteroidetes,47RPA@768503|Cytophagia	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_10,TetR_N
MMS1_k127_1725153_1	573413.Spirs_4033	4.56e-71	266.0	COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
MMS1_k127_1725153_0	44251.PDUR_26900	4.873e-74	252.0	COG2249@1|root,COG2249@2|Bacteria,1U3MF@1239|Firmicutes,4HCM7@91061|Bacilli,26TZS@186822|Paenibacillaceae	91061|Bacilli	S	NADPH dehydrogenase	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
MMS1_k127_1725818_2	889378.Spiaf_0277	2.013e-08	64.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_1725818_1	1307761.L21SP2_2912	4.954e-36	155.0	COG0840@1|root,COG0840@2|Bacteria,2JADS@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_1725818_0	573413.Spirs_0492	4.653e-70	250.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_1725818_3	744872.Spica_0846	3.293e-07	58.0	COG0840@1|root,COG0840@2|Bacteria,2J7YR@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_1726032_2	573413.Spirs_0602	1.004e-15	76.0	COG1592@1|root,COG1592@2|Bacteria,2J5MR@203691|Spirochaetes	203691|Spirochaetes	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS1_k127_1726032_0	1307761.L21SP2_2131	9.94e-126	408.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	ABM,Rhodanese,STAS,Sulfate_transp
MMS1_k127_1726032_1	1307761.L21SP2_2132	1.363e-72	253.0	COG4939@1|root,COG4939@2|Bacteria,2JAT3@203691|Spirochaetes	203691|Spirochaetes	S	FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
MMS1_k127_1728118_1	665571.STHERM_c13430	4.603e-74	259.0	COG0079@1|root,COG0079@2|Bacteria,2J8KB@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9,4.1.1.81	ko:K00817,ko:K04720	ko00340,ko00350,ko00360,ko00400,ko00401,ko00860,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243,R06530	RC00006,RC00517,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_1728118_3	744872.Spica_1886	1.047e-47	176.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS1_k127_1728118_0	573413.Spirs_0929	0.0	1170.0	COG0542@1|root,COG0542@2|Bacteria,2J57C@203691|Spirochaetes	203691|Spirochaetes	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
MMS1_k127_1728118_2	1499967.BAYZ01000075_gene2071	1.28e-62	230.0	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS-HPr
MMS1_k127_1729483_1	886379.AEWI01000053_gene2675	5.126e-54	191.0	COG3118@1|root,COG3118@2|Bacteria,4NQNX@976|Bacteroidetes,2FSPP@200643|Bacteroidia,3XK5P@558415|Marinilabiliaceae	976|Bacteroidetes	O	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
MMS1_k127_1729483_0	1123274.KB899426_gene2816	1.819e-171	550.0	COG0165@1|root,COG0165@2|Bacteria,2J5FG@203691|Spirochaetes	203691|Spirochaetes	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
MMS1_k127_1729483_2	889378.Spiaf_0991	0.0001561	53.0	COG1520@1|root,COG4254@1|root,COG1520@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Big_3_2,FecR,LysM,PQQ_2
MMS1_k127_1731159_2	1249627.D779_2455	6.43e-28	119.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWY7@135613|Chromatiales	135613|Chromatiales	NT	Signal transducing histidine kinase, homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
MMS1_k127_1731159_1	177437.HRM2_34380	3.519e-36	143.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,43AFQ@68525|delta/epsilon subdivisions,2X5VI@28221|Deltaproteobacteria,2MJRP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_1731159_0	439235.Dalk_2351	1.914e-84	296.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MINP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HBM,MCPsignal,dCache_1
MMS1_k127_173413_2	748727.CLJU_c20200	6.868e-15	78.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae	186801|Clostridia	KQ	Sigma54 specific transcriptional regulator, Fis family	aorR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
MMS1_k127_173413_0	1511.CLOST_0827	0.0	1011.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
MMS1_k127_173413_1	1511.CLOST_0826	1.502e-42	158.0	COG1977@1|root,COG1977@2|Bacteria,1VFFW@1239|Firmicutes,24VXP@186801|Clostridia	186801|Clostridia	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
MMS1_k127_173413_3	536227.CcarbDRAFT_3472	6.263e-13	73.0	COG1977@1|root,COG1977@2|Bacteria,1VIST@1239|Firmicutes,24QYP@186801|Clostridia,36NC4@31979|Clostridiaceae	186801|Clostridia	H	ThiS family	moaD	-	-	-	-	-	-	-	-	-	-	-	ThiS
MMS1_k127_1734674_0	744872.Spica_0958	2.273e-221	701.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J5F4@203691|Spirochaetes	203691|Spirochaetes	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
MMS1_k127_1736440_1	889378.Spiaf_1858	5.185e-78	271.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_1736440_0	706587.Desti_3270	1.105e-108	381.0	COG2202@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_1737781_0	926561.KB900617_gene1607	1.369e-114	375.0	COG5520@1|root,COG5520@2|Bacteria,1TS99@1239|Firmicutes,249YD@186801|Clostridia,3WBKD@53433|Halanaerobiales	186801|Clostridia	M	Glycosyl hydrolase family 30 beta sandwich domain	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	F5_F8_type_C,Glyco_hydro_30,Glyco_hydro_30C
MMS1_k127_1737781_1	665571.STHERM_c13860	4.746e-66	238.0	COG1609@1|root,COG1609@2|Bacteria,2J7A9@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1738624_5	1480694.DC28_00415	8.377e-14	78.0	COG1269@1|root,COG1269@2|Bacteria,2J594@203691|Spirochaetes	203691|Spirochaetes	C	V-type ATP synthase, subunit I	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS1_k127_1738624_2	221027.JO40_10775	1.707e-72	249.0	COG1394@1|root,COG1394@2|Bacteria,2J59S@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS1_k127_1738624_1	744872.Spica_1502	7.127e-237	737.0	COG1156@1|root,COG1156@2|Bacteria,2J574@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_1738624_0	545695.TREAZ_0100	1.092e-285	886.0	COG1155@1|root,COG1155@2|Bacteria,2J59J@203691|Spirochaetes	203691|Spirochaetes	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS1_k127_1738624_4	744872.Spica_1504	5.335e-23	106.0	2EBXS@1|root,335X4@2|Bacteria,2J86W@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2764
MMS1_k127_1738624_3	573413.Spirs_2461	4.841e-25	109.0	COG1390@1|root,COG1390@2|Bacteria,2J7I5@203691|Spirochaetes	203691|Spirochaetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	DivIVA,vATP-synt_E
MMS1_k127_1739919_2	314285.KT71_17656	2.178e-51	187.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,1RRXR@1236|Gammaproteobacteria,1JAET@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1739919_1	889378.Spiaf_1044	3.248e-53	207.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,Hemerythrin,MCPsignal,dCache_1
MMS1_k127_1739919_4	679926.Mpet_1128	2.762e-09	70.0	COG0642@1|root,arCOG06712@1|root,arCOG06192@2157|Archaea,arCOG06193@2157|Archaea,arCOG06712@2157|Archaea,2XWN9@28890|Euryarchaeota,2NANJ@224756|Methanomicrobia	2157|Archaea	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_1739919_0	573413.Spirs_3391	6.548e-56	217.0	COG2197@1|root,COG3290@1|root,COG2197@2|Bacteria,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.1.1.80,2.7.11.1,2.7.13.3,3.1.1.61,3.1.3.3	ko:K07315,ko:K07701,ko:K12132,ko:K13924	ko02020,ko02030,map02020,map02030	M00488,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_7,GGDEF,GerE,HATPase_c,PAS,PAS_3,PAS_4,PAS_9
MMS1_k127_1739919_3	1121335.Clst_2176	4.368e-19	90.0	COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
MMS1_k127_1740609_0	471856.Jden_0472	2.613e-204	650.0	COG1472@1|root,COG1472@2|Bacteria,2GQQR@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolase family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1740751_2	665571.STHERM_c08280	4.358e-17	84.0	COG1070@1|root,COG1070@2|Bacteria,2J5PS@203691|Spirochaetes	203691|Spirochaetes	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
MMS1_k127_1740751_1	1178825.ALIH01000004_gene2790	2.902e-44	162.0	COG3254@1|root,COG3254@2|Bacteria,4NSEM@976|Bacteroidetes,1I4MI@117743|Flavobacteriia	976|Bacteroidetes	G	Involved in the anomeric conversion of L-rhamnose	rhaU	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
MMS1_k127_1740751_0	158190.SpiGrapes_2585	5.374e-112	371.0	COG1172@1|root,COG1172@2|Bacteria,2J84S@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K10561	ko02010,map02010	M00212,M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.9	-	-	BPD_transp_2
MMS1_k127_1740751_3	1437448.AZRT01000032_gene2574	1.637e-09	60.0	COG1172@1|root,COG1172@2|Bacteria,1MWN4@1224|Proteobacteria,2TV3R@28211|Alphaproteobacteria,1J3S0@118882|Brucellaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	rhaP	-	-	ko:K10556,ko:K10560	ko02010,ko02024,map02010,map02024	M00219,M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.8,3.A.1.2.9	-	-	BPD_transp_2
MMS1_k127_1741255_7	1401067.HMPREF0872_05470	5.622e-05	48.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,4H4VJ@909932|Negativicutes	909932|Negativicutes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS1_k127_1741255_2	459349.CLOAM1161	1.391e-103	347.0	COG0482@1|root,COG0482@2|Bacteria,2NNPW@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
MMS1_k127_1741255_6	660470.Theba_1561	5.525e-18	94.0	COG0834@1|root,COG2199@1|root,COG2202@1|root,COG3437@1|root,COG0834@2|Bacteria,COG2199@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,2GE0F@200918|Thermotogae	200918|Thermotogae	T	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,SBP_bac_3
MMS1_k127_1741255_4	573413.Spirs_0092	1.024e-58	214.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS1_k127_1741255_5	525897.Dbac_2830	1.1e-52	199.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42Y7R@68525|delta/epsilon subdivisions,2WUPP@28221|Deltaproteobacteria,2MHD5@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
MMS1_k127_1741255_3	380703.AHA_3588	2.017e-79	279.0	COG2937@1|root,COG2937@2|Bacteria,1QTSP@1224|Proteobacteria,1T1FV@1236|Gammaproteobacteria,1Y43K@135624|Aeromonadales	135624|Aeromonadales	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
MMS1_k127_1741255_0	1292035.H476_0628	6.712e-181	572.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia	186801|Clostridia	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS1_k127_1741255_1	1307761.L21SP2_3086	6.948e-124	404.0	COG0395@1|root,COG0395@2|Bacteria,2J5I1@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1741632_4	316067.Geob_2265	0.0001024	46.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_1741632_1	243231.GSU0683	1.025e-105	369.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,CZB,HAMP,MCPsignal,dCache_1
MMS1_k127_1741632_3	580327.Tthe_2127	1.506e-24	116.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,42G7T@68295|Thermoanaerobacterales	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
MMS1_k127_1741632_0	243231.GSU3418	7.174e-150	487.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,42NMK@68525|delta/epsilon subdivisions,2WK6K@28221|Deltaproteobacteria,43TU9@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_1741632_2	1121441.AUCX01000010_gene112	4.952e-56	220.0	COG4191@1|root,COG4936@1|root,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM1A@28221|Deltaproteobacteria,2MAT9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3,sCache_2
MMS1_k127_1743178_2	573413.Spirs_2076	8.198e-25	112.0	COG0457@1|root,COG0457@2|Bacteria,2J7G0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
MMS1_k127_1743178_4	228405.HNE_0478	2.14e-06	54.0	2DEJE@1|root,2ZN82@2|Bacteria,1PB33@1224|Proteobacteria,2UY1B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1743178_1	573413.Spirs_2077	1.145e-79	275.0	COG1579@1|root,COG1579@2|Bacteria,2J6JN@203691|Spirochaetes	203691|Spirochaetes	S	Zn-ribbon protein, possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
MMS1_k127_1743178_0	1123274.KB899421_gene1809	1.791e-240	760.0	COG0568@1|root,COG0568@2|Bacteria,2J59P@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_1743178_3	573413.Spirs_2079	4.233e-16	82.0	COG0358@1|root,COG0358@2|Bacteria,2J5MX@203691|Spirochaetes	203691|Spirochaetes	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
MMS1_k127_174743_0	1202532.FF52_20647	2.187e-119	399.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes,1HYHN@117743|Flavobacteriia,2NVGY@237|Flavobacterium	976|Bacteroidetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS1_k127_174743_1	243275.TDE_0205	7.257e-104	349.0	COG2114@1|root,COG2114@2|Bacteria,2J6YU@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	2TM,Guanylate_cyc
MMS1_k127_1750189_9	1090318.ATTI01000001_gene510	6.202e-06	54.0	2BVGP@1|root,32QVG@2|Bacteria,1MYPP@1224|Proteobacteria,2UA2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1750189_0	1123274.KB899409_gene549	0.0	1278.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,2JA0V@203691|Spirochaetes	203691|Spirochaetes	C	xanthine dehydrogenase, a b hammerhead	-	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
MMS1_k127_1750189_7	1524467.IV04_04690	2.926e-28	124.0	COG1319@1|root,COG1319@2|Bacteria,1Q59D@1224|Proteobacteria,1RZFY@1236|Gammaproteobacteria,400JS@613|Serratia	1236|Gammaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	ygfM	-	-	ko:K12529	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS1_k127_1750189_5	573413.Spirs_1391	3.772e-76	267.0	COG1319@1|root,COG1319@2|Bacteria,2J80S@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	coxM	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS1_k127_1750189_6	573413.Spirs_1390	4.83e-64	222.0	COG2080@1|root,COG2080@2|Bacteria,2J812@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	coxS	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS1_k127_1750189_2	1123274.KB899409_gene554	7.191e-257	812.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS1_k127_1750189_3	1499967.BAYZ01000188_gene3895	2.571e-209	655.0	COG0624@1|root,COG0624@2|Bacteria,2NNX2@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS1_k127_1750189_4	1123274.KB899409_gene556	7.797e-194	614.0	COG0402@1|root,COG0402@2|Bacteria,2J5A0@203691|Spirochaetes	203691|Spirochaetes	F	selenium metabolism protein SsnA	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
MMS1_k127_1750189_1	362663.ECP_2872	0.0	1156.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,3XNXA@561|Escherichia	1236|Gammaproteobacteria	C	Could be an iron-sulfur flavoprotein with NADPH O(2) oxidoreductase activity	ygfK	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0055114	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
MMS1_k127_1757052_3	1307761.L21SP2_2815	5.099e-55	196.0	COG1846@1|root,COG1846@2|Bacteria,2J79K@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS1_k127_1757052_2	1304284.L21TH_1355	3.638e-85	299.0	COG0454@1|root,COG0498@1|root,COG0456@2|Bacteria,COG0498@2|Bacteria,1V644@1239|Firmicutes,24J18@186801|Clostridia	186801|Clostridia	EK	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,PALP
MMS1_k127_1757052_4	889378.Spiaf_1445	1.682e-13	75.0	COG0828@1|root,COG0828@2|Bacteria,2J8QT@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
MMS1_k127_1757052_1	889378.Spiaf_0682	2.831e-103	346.0	COG1609@1|root,COG1609@2|Bacteria,2J6QG@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529,ko:K03435	-	-	-	-	ko00000,ko03000	-	-	-	LacI
MMS1_k127_1757052_0	596151.DesfrDRAFT_0728	5.766e-194	629.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WJ6F@28221|Deltaproteobacteria,2MG23@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PEP-utilising enzyme, N-terminal	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2
MMS1_k127_175727_4	313612.L8106_16134	3.47e-08	58.0	COG5266@1|root,COG5266@2|Bacteria,1G83Z@1117|Cyanobacteria,1HC3V@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM Nickel transport complex, NikM subunit, transmembrane	-	-	-	ko:K16915	ko02010,map02010	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	CarboxypepD_reg
MMS1_k127_175727_1	767817.Desgi_0732	2.135e-49	186.0	28I7C@1|root,2Z8A8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_175727_2	941824.TCEL_01573	2.456e-47	181.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia,36FN5@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator DeoR family	-	-	-	ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
MMS1_k127_175727_0	56780.SYN_00476	1.35e-121	404.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
MMS1_k127_175727_3	332101.JIBU02000012_gene859	4.91e-41	158.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
MMS1_k127_1757316_0	545695.TREAZ_0275	1.916e-71	255.0	COG2265@1|root,COG2265@2|Bacteria,2J5Y7@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	ygcA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
MMS1_k127_1757316_1	1449063.JMLS01000002_gene1345	1.135e-20	104.0	COG1520@1|root,COG5184@1|root,COG5492@1|root,COG1520@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1V9TE@1239|Firmicutes,4HJ03@91061|Bacilli,26ZCQ@186822|Paenibacillaceae	91061|Bacilli	G	PQQ-like domain	yxaL	-	-	-	-	-	-	-	-	-	-	-	Big_2,PQQ,PQQ_2,PQQ_3,SLH
MMS1_k127_1758788_1	986075.CathTA2_0169	2.109e-51	192.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,4HA1G@91061|Bacilli	91061|Bacilli	G	COG0366 Glycosidases	malL	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
MMS1_k127_1758788_0	1423321.AS29_03065	1.058e-93	317.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,4HAW3@91061|Bacilli,1ZDHS@1386|Bacillus	91061|Bacilli	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
MMS1_k127_1760278_0	1307761.L21SP2_1499	7.633e-74	263.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_1760278_1	903814.ELI_1690	2.409e-10	65.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,25V6C@186806|Eubacteriaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
MMS1_k127_1763890_2	574376.BAMA_06730	5.008e-34	138.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,4HBP5@91061|Bacilli,1ZC85@1386|Bacillus	91061|Bacilli	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3372,PUD
MMS1_k127_1763890_0	1123274.KB899423_gene1651	6.433e-121	409.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_1763890_1	398512.JQKC01000005_gene5566	1.346e-46	184.0	COG2360@1|root,COG2360@2|Bacteria	2|Bacteria	O	leucyltransferase activity	aat	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
MMS1_k127_1765986_0	868595.Desca_2531	9.083e-195	623.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,25ZXQ@186807|Peptococcaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
MMS1_k127_176676_1	1304874.JAFY01000005_gene1174	1.093e-40	151.0	COG0019@1|root,COG0019@2|Bacteria,3TA7F@508458|Synergistetes	508458|Synergistetes	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
MMS1_k127_176676_0	243275.TDE_1941	1.094e-41	172.0	29WTR@1|root,30IF4@2|Bacteria,2J6NC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1770047_1	929558.SMGD1_1761	2.066e-30	128.0	COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42UYY@68525|delta/epsilon subdivisions	1224|Proteobacteria	PT	Diguanylate cyclase, possibly nitrate nitrite or cation sensing (GGDEF HAMP linker domain, Hemerythrin HHE domain)	-	-	2.7.7.65	ko:K21088	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,Hemerythrin,NIT,PilJ,dCache_3
MMS1_k127_1770047_2	573413.Spirs_3349	9.61e-27	114.0	2E4SV@1|root,32ZM7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
MMS1_k127_1770047_0	247633.GP2143_16501	4.176e-203	642.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1J4D3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2699	PALP,Thr_dehydrat_C
MMS1_k127_1771020_0	373903.Hore_11000	1.039e-81	278.0	COG1235@1|root,COG1235@2|Bacteria,1V2ET@1239|Firmicutes,24E1K@186801|Clostridia,3WA8A@53433|Halanaerobiales	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
MMS1_k127_1771020_1	1123274.KB899418_gene2366	2.218e-31	124.0	COG0227@1|root,COG0227@2|Bacteria,2J99Q@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
MMS1_k127_177283_2	1123274.KB899411_gene3235	6.997e-89	297.0	COG1653@1|root,COG1653@2|Bacteria,2J7XP@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
MMS1_k127_177283_0	1123274.KB899411_gene3236	4.811e-113	373.0	COG1175@1|root,COG1175@2|Bacteria,2J7QQ@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
MMS1_k127_177283_1	1123274.KB899411_gene3237	2.113e-104	349.0	COG0395@1|root,COG0395@2|Bacteria,2J8NE@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
MMS1_k127_177283_3	1123274.KB899427_gene3313	2.017e-44	163.0	COG0640@1|root,COG0640@2|Bacteria,2JAK1@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
MMS1_k127_1773444_0	177437.HRM2_43440	1.858e-187	600.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MIPD@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
MMS1_k127_1773444_1	1391646.AVSU01000056_gene1309	9.476e-72	250.0	COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,25QN6@186804|Peptostreptococcaceae	186801|Clostridia	D	Anion-transporting ATPase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
MMS1_k127_1776469_2	1423724.BAMM01000010_gene1181	6.938e-07	56.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes	1239|Firmicutes	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
MMS1_k127_1776469_1	742817.HMPREF9449_01756	1.685e-37	150.0	COG1404@1|root,COG4870@1|root,COG1404@2|Bacteria,COG4870@2|Bacteria,4NQK4@976|Bacteroidetes,2FV4Q@200643|Bacteroidia	976|Bacteroidetes	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
MMS1_k127_1776469_0	1307761.L21SP2_3165	3.17e-56	205.0	COG5464@1|root,COG5464@2|Bacteria,2J8ZJ@203691|Spirochaetes	203691|Spirochaetes	S	PD-(D/E)XK nuclease family transposase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
MMS1_k127_1776942_0	335543.Sfum_2177	2.623e-60	231.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2WKJ1@28221|Deltaproteobacteria,2MRBJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
MMS1_k127_1776942_2	574087.Acear_1485	1.128e-42	177.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_3_3
MMS1_k127_1776942_1	1191523.MROS_2123	4.85e-54	207.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
MMS1_k127_1777578_0	573413.Spirs_1817	8.413e-262	820.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
MMS1_k127_1780483_0	1307761.L21SP2_2078	3.327e-88	297.0	COG3666@1|root,COG3666@2|Bacteria,2J98U@203691|Spirochaetes	203691|Spirochaetes	L	COG3666 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
MMS1_k127_1780483_2	509190.Cseg_0779	2.741e-13	71.0	COG4221@1|root,COG4221@2|Bacteria,1QVR1@1224|Proteobacteria,2TXH2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_1780483_1	316273.XCV0060	7.619e-81	273.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1XCAQ@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_1780723_4	1480694.DC28_14590	4.058e-31	137.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
MMS1_k127_1780723_0	889378.Spiaf_2857	1.672e-171	544.0	COG0082@1|root,COG0082@2|Bacteria,2J5CX@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
MMS1_k127_1780723_1	36331.EPrPI00000014187	1.818e-48	184.0	COG3752@1|root,KOG4650@2759|Eukaryota,1MJ17@121069|Pythiales	121069|Pythiales	S	Protein of unknown function (DUF1295)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
MMS1_k127_1780723_3	573413.Spirs_2330	3.114e-31	124.0	COG0724@1|root,COG0724@2|Bacteria,2J8UF@203691|Spirochaetes	203691|Spirochaetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
MMS1_k127_1780723_2	1163671.JAGI01000002_gene2230	2.358e-43	164.0	COG3467@1|root,COG3467@2|Bacteria,1V7MR@1239|Firmicutes,25B09@186801|Clostridia,36W93@31979|Clostridiaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
MMS1_k127_1780723_5	573413.Spirs_4146	6.485e-20	93.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria	2|Bacteria	T	EAL domain	yjcC	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
MMS1_k127_1781265_3	545694.TREPR_3513	5.848e-40	151.0	COG0347@1|root,COG0347@2|Bacteria,2J7M4@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
MMS1_k127_1781265_1	338966.Ppro_3249	4.169e-153	494.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42ZDZ@68525|delta/epsilon subdivisions,2WTXC@28221|Deltaproteobacteria,43TRQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PFAM Rh family protein ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS1_k127_1781265_2	471854.Dfer_4580	7.718e-152	516.0	COG0553@1|root,COG0553@2|Bacteria,4NG6P@976|Bacteroidetes,47JVA@768503|Cytophagia	976|Bacteroidetes	L	PFAM Helicase conserved C-terminal domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
MMS1_k127_1781265_0	1304885.AUEY01000050_gene1198	1.715e-223	702.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2MINJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMS1_k127_1782466_3	1280666.ATVS01000009_gene1192	4.979e-30	121.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,4BWYB@830|Butyrivibrio	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
MMS1_k127_1782466_2	1123274.KB899411_gene3131	7.888e-32	128.0	2C3HB@1|root,333QE@2|Bacteria,2J8P5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1782466_4	744872.Spica_0882	4.932e-15	81.0	2BHG9@1|root,2ZJEX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1782466_0	665571.STHERM_c01900	7.225e-94	321.0	COG2304@1|root,COG2304@2|Bacteria,2J5Y4@203691|Spirochaetes	203691|Spirochaetes	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
MMS1_k127_1782466_1	889378.Spiaf_1413	2.42e-34	132.0	COG1028@1|root,COG1028@2|Bacteria	889378.Spiaf_1413|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
MMS1_k127_178409_1	550540.Fbal_2564	1.595e-70	248.0	COG1092@1|root,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,1RN8N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
MMS1_k127_178409_0	877420.ATVW01000006_gene564	2.275e-115	376.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,27IAG@186928|unclassified Lachnospiraceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
MMS1_k127_1785335_3	717231.Flexsi_1329	1.098e-32	134.0	COG1335@1|root,COG1335@2|Bacteria,2GFP3@200930|Deferribacteres	200930|Deferribacteres	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS1_k127_1785335_0	589865.DaAHT2_1680	3.448e-112	372.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2MHVY@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1785335_2	1128398.Curi_c08420	1.012e-36	149.0	COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,24AQJ@186801|Clostridia,268X9@186813|unclassified Clostridiales	186801|Clostridia	NT	Methyltransferase, chemotaxis proteins	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
MMS1_k127_1785335_1	1232437.KL662014_gene1293	2.025e-44	170.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MINP@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HBM,MCPsignal
MMS1_k127_1785669_0	572544.Ilyop_1582	5.551e-147	477.0	COG1053@1|root,COG1053@2|Bacteria,379QD@32066|Fusobacteria	32066|Fusobacteria	C	HI0933-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FMN_bind
MMS1_k127_1785669_2	1033810.HLPCO_000750	2.898e-82	282.0	COG4176@1|root,COG4176@2|Bacteria	2|Bacteria	P	choline transport	proW	-	-	ko:K02001,ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
MMS1_k127_1785669_1	485916.Dtox_0515	2.953e-122	404.0	COG4175@1|root,COG4175@2|Bacteria,1UHNE@1239|Firmicutes,25EJ1@186801|Clostridia,260VY@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM glycine betaine L-proline	opuAA	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran,CBS
MMS1_k127_1785669_3	526222.Desal_0817	1.254e-59	213.0	COG2113@1|root,COG2113@2|Bacteria,1R5CU@1224|Proteobacteria,42Q8G@68525|delta/epsilon subdivisions,2WKJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Substrate-binding region of ABC-type glycine betaine transport system	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
MMS1_k127_1785848_1	886379.AEWI01000026_gene415	1.04e-12	70.0	COG1127@1|root,COG1127@2|Bacteria,4NETG@976|Bacteroidetes,2FM5W@200643|Bacteroidia,3XJCG@558415|Marinilabiliaceae	976|Bacteroidetes	Q	ATPases associated with a variety of cellular activities	metN	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
MMS1_k127_1785848_0	573413.Spirs_1735	3.008e-73	256.0	COG0767@1|root,COG0767@2|Bacteria,2J7BX@203691|Spirochaetes	203691|Spirochaetes	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
MMS1_k127_1790156_4	926550.CLDAP_00570	1.06e-11	68.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG3829@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5000@2|Bacteria,2G7J9@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg
MMS1_k127_1790156_5	1536770.R50345_03685	8.293e-09	61.0	COG0823@1|root,COG0823@2|Bacteria,1VRCB@1239|Firmicutes,4HTBY@91061|Bacilli,26UZ0@186822|Paenibacillaceae	91061|Bacilli	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
MMS1_k127_1790156_0	573413.Spirs_3388	2.781e-115	378.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_1790156_1	573061.Clocel_0927	1.284e-106	353.0	COG1028@1|root,COG1028@2|Bacteria,1TSJI@1239|Firmicutes,24EFJ@186801|Clostridia,36H1H@31979|Clostridiaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
MMS1_k127_1790156_3	478749.BRYFOR_08931	1.467e-74	256.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,24F5H@186801|Clostridia	1239|Firmicutes	K	Psort location Cytoplasmic, score 9.98	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_1790156_2	1121333.JMLH01000060_gene1443	2.325e-90	308.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,3VPYK@526524|Erysipelotrichia	526524|Erysipelotrichia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMS1_k127_1791778_1	1123248.KB893314_gene3516	1.667e-40	157.0	COG0581@1|root,COG0581@2|Bacteria,4NGBA@976|Bacteroidetes,1IPR0@117747|Sphingobacteriia	976|Bacteroidetes	P	Phosphate transport system permease protein	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS1_k127_1791778_0	667014.Thein_1293	3.73e-48	177.0	COG0573@1|root,COG0573@2|Bacteria,2GHGV@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS1_k127_1792664_2	592316.Pat9b_1837	6.466e-18	91.0	2AFQE@1|root,315S9@2|Bacteria,1RHHZ@1224|Proteobacteria,1S7HB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1792664_0	431943.CKL_1121	8.737e-87	295.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,36DKI@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS1_k127_1792664_1	331869.BAL199_10230	1.108e-43	169.0	COG0834@1|root,COG0834@2|Bacteria,1PWW3@1224|Proteobacteria,2UJKH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_1794101_1	545694.TREPR_2469	3.944e-16	83.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_1794101_0	869209.Tresu_2066	3.339e-42	167.0	COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,2J72G@203691|Spirochaetes	203691|Spirochaetes	M	LysM domain M23 M37 peptidase domain protein	lysM	-	-	ko:K06194	-	-	-	-	ko00000	1.A.34.1.2	-	-	Amidase_3,LysM,Peptidase_M23
MMS1_k127_1794993_1	1307761.L21SP2_0473	4.268e-48	198.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_1794993_0	489825.LYNGBM3L_42570	7.709e-78	271.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H9WN@1150|Oscillatoriales	1117|Cyanobacteria	T	7TM diverse intracellular signalling	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
MMS1_k127_1803364_1	760011.Spico_1458	3.535e-08	57.0	COG0584@1|root,COG0584@2|Bacteria,2J6RW@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
MMS1_k127_1803364_0	744872.Spica_2503	1.511e-21	109.0	2CAZD@1|root,342TQ@2|Bacteria,2J9GV@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1805093_0	573413.Spirs_2268	3.889e-255	806.0	COG0465@1|root,COG0465@2|Bacteria,2J58Y@203691|Spirochaetes	203691|Spirochaetes	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
MMS1_k127_1805093_1	1267535.KB906767_gene2433	2.88e-130	432.0	COG0550@1|root,COG0550@2|Bacteria,3Y343@57723|Acidobacteria,2JHPW@204432|Acidobacteriia	204432|Acidobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS1_k127_1805343_2	1307761.L21SP2_0498	2.295e-73	249.0	COG0362@1|root,COG0362@2|Bacteria,2J661@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
MMS1_k127_1805343_1	1307761.L21SP2_0499	1.273e-77	268.0	COG1349@1|root,COG1349@2|Bacteria,2J87G@203691|Spirochaetes	203691|Spirochaetes	K	DeoR C terminal sensor domain	-	-	-	ko:K02081	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
MMS1_k127_1805343_0	1168289.AJKI01000036_gene3416	1.219e-181	573.0	COG0524@1|root,COG0524@2|Bacteria,4NH8K@976|Bacteroidetes,2FM8P@200643|Bacteroidia,3XIZT@558415|Marinilabiliaceae	976|Bacteroidetes	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
MMS1_k127_1805343_4	1117958.PE143B_0128510	4.022e-64	222.0	2E1WY@1|root,308BX@2|Bacteria,1NXHA@1224|Proteobacteria,1SQKP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1805343_3	1123401.JHYQ01000003_gene2172	1.012e-69	239.0	COG4637@1|root,COG4637@2|Bacteria,1RFHJ@1224|Proteobacteria,1SZIS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
MMS1_k127_1806199_0	994573.T472_0218930	3.168e-101	339.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,36G47@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_1806415_0	1499967.BAYZ01000173_gene5786	4.376e-158	517.0	COG0574@1|root,COG0574@2|Bacteria,2NQKM@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
MMS1_k127_1807954_0	1480694.DC28_09080	8.204e-150	484.0	COG1022@1|root,COG1022@2|Bacteria,2J9S5@203691|Spirochaetes	203691|Spirochaetes	I	Long-chain acyl-CoA synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
MMS1_k127_181051_3	523845.AQXV01000036_gene497	5.728e-52	192.0	COG4121@1|root,arCOG00120@2157|Archaea,2XV6C@28890|Euryarchaeota,23QF0@183939|Methanococci	183939|Methanococci	S	S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_30
MMS1_k127_181051_0	1158338.JNLJ01000001_gene1027	6.241e-89	305.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G3S5@200783|Aquificae	200783|Aquificae	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
MMS1_k127_181051_2	748727.CLJU_c22080	5.012e-52	191.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,36GCB@31979|Clostridiaceae	186801|Clostridia	H	riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
MMS1_k127_181051_1	795359.TOPB45_0960	8.383e-67	236.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GHPG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
MMS1_k127_1810941_6	573413.Spirs_0898	1.506e-33	136.0	COG1538@1|root,COG1538@2|Bacteria,2J6ZZ@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
MMS1_k127_1810941_5	1095769.CAHF01000023_gene465	1.356e-37	151.0	COG2382@1|root,COG2382@2|Bacteria,1QWH3@1224|Proteobacteria,2WGZS@28216|Betaproteobacteria	28216|Betaproteobacteria	P	esterase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1810941_4	1128398.Curi_c05130	1.017e-46	182.0	COG0454@1|root,COG0456@2|Bacteria,1TS4G@1239|Firmicutes,25DBT@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS1_k127_1810941_7	760192.Halhy_4887	1.957e-30	124.0	COG4319@1|root,COG4319@2|Bacteria,4NSIN@976|Bacteroidetes	976|Bacteroidetes	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
MMS1_k127_1810941_8	1347086.CCBA010000007_gene4536	3.818e-16	87.0	COG1073@1|root,COG1073@2|Bacteria,1V3T7@1239|Firmicutes,4HH6G@91061|Bacilli,1ZD5P@1386|Bacillus	91061|Bacilli	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1810941_2	1121334.KB911070_gene1427	3.923e-171	543.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,2482X@186801|Clostridia,3WHCQ@541000|Ruminococcaceae	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
MMS1_k127_1810941_1	1121334.KB911070_gene1428	9.655e-206	646.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,24XS9@186801|Clostridia,3WGFE@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
MMS1_k127_1810941_0	1121334.KB911070_gene1429	1.304e-275	853.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
MMS1_k127_1810941_3	1232447.BAHW02000027_gene1813	6.779e-67	235.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,249ZI@186801|Clostridia	186801|Clostridia	G	COG COG1879 ABC-type sugar transport system, periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_181242_3	1123009.AUID01000016_gene60	1.122e-47	174.0	2EG7Z@1|root,339ZT@2|Bacteria,1VNA0@1239|Firmicutes,24FGJ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_181242_1	903818.KI912268_gene956	9.628e-108	356.0	COG0280@1|root,COG0280@2|Bacteria,3Y4QI@57723|Acidobacteria	57723|Acidobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
MMS1_k127_181242_0	1449126.JQKL01000002_gene1569	6.505e-138	446.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,26A52@186813|unclassified Clostridiales	186801|Clostridia	C	Acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
MMS1_k127_181242_2	1042156.CXIVA_09280	1.473e-86	304.0	COG2271@1|root,COG2271@2|Bacteria,1UYAA@1239|Firmicutes,24X2M@186801|Clostridia	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1815962_0	1218173.BALCAV_0202005	8.38e-125	409.0	COG0673@1|root,COG0673@2|Bacteria,1TNYR@1239|Firmicutes,4HAZU@91061|Bacilli,1ZCPS@1386|Bacillus	91061|Bacilli	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1817001_4	906968.Trebr_2506	2.932e-25	112.0	28R06@1|root,2ZDEW@2|Bacteria,2JASI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1817001_5	1268622.AVS7_03286	2.495e-09	68.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,4AC4K@80864|Comamonadaceae	28216|Betaproteobacteria	K	response regulator	vsrC	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_1817001_0	313603.FB2170_12286	6.688e-249	776.0	COG0059@1|root,COG0059@2|Bacteria,4NFYV@976|Bacteroidetes,1HYM2@117743|Flavobacteriia,2PGMX@252356|Maribacter	976|Bacteroidetes	EH	Acetohydroxy acid isomeroreductase, catalytic domain	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
MMS1_k127_1817001_2	1449050.JNLE01000003_gene241	1.538e-47	174.0	COG2172@1|root,COG2172@2|Bacteria,1V6YP@1239|Firmicutes,24JJ0@186801|Clostridia,36JQQ@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase-like ATPase domain	RsbW	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
MMS1_k127_1817001_1	398512.JQKC01000016_gene2856	2.497e-131	432.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,3WGD2@541000|Ruminococcaceae	186801|Clostridia	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
MMS1_k127_1817001_3	573413.Spirs_0337	3.916e-43	161.0	COG1378@1|root,COG1378@2|Bacteria,2J92Z@203691|Spirochaetes	203691|Spirochaetes	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMS1_k127_1823427_6	889378.Spiaf_1277	5.624e-40	156.0	COG4284@1|root,COG4284@2|Bacteria,2J6J4@203691|Spirochaetes	203691|Spirochaetes	G	UTP--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGP
MMS1_k127_1823427_2	1307761.L21SP2_2633	1.704e-60	226.0	COG1940@1|root,COG1940@2|Bacteria,2J5IZ@203691|Spirochaetes	203691|Spirochaetes	K	pfam rok	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
MMS1_k127_1823427_0	1480694.DC28_09655	1.044e-163	524.0	COG0205@1|root,COG0205@2|Bacteria,2J7BI@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
MMS1_k127_1823427_5	344747.PM8797T_00699	3.242e-41	162.0	COG2120@1|root,COG2120@2|Bacteria,2IYPC@203682|Planctomycetes	203682|Planctomycetes	S	LmbE homologs	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
MMS1_k127_1823427_1	1480694.DC28_09665	2.374e-111	368.0	COG2222@1|root,COG2222@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
MMS1_k127_1823427_8	665571.STHERM_c13190	3.664e-19	89.0	COG0360@1|root,COG0360@2|Bacteria,2J88X@203691|Spirochaetes	203691|Spirochaetes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
MMS1_k127_1823427_4	573413.Spirs_2878	4.277e-44	164.0	COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
MMS1_k127_1823427_7	545695.TREAZ_0630	7.812e-31	123.0	COG0238@1|root,COG0238@2|Bacteria,2J8ZY@203691|Spirochaetes	203691|Spirochaetes	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
MMS1_k127_1823427_9	1123274.KB899412_gene1510	1.822e-11	70.0	2DZ40@1|root,34CCA@2|Bacteria,2J8AY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
MMS1_k127_1823427_3	744872.Spica_1425	1.561e-44	168.0	COG0359@1|root,COG0359@2|Bacteria,2J6J9@203691|Spirochaetes	203691|Spirochaetes	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
MMS1_k127_1823735_0	665571.STHERM_c09420	9.737e-203	641.0	COG0119@1|root,COG0119@2|Bacteria,2J6AF@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
MMS1_k127_1826497_0	744872.Spica_0696	7.504e-73	260.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria,2JAA0@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Response_reg,SpoIIE
MMS1_k127_1826497_1	573413.Spirs_1615	9.852e-60	222.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
MMS1_k127_1826497_2	580331.Thit_1844	1.25e-51	205.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1V2NQ@1239|Firmicutes,25KP2@186801|Clostridia,42I7M@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMS1_k127_182779_2	273121.WS1004	5.494e-72	262.0	COG0155@1|root,COG0425@1|root,COG0155@2|Bacteria,COG0425@2|Bacteria,1MVVB@1224|Proteobacteria,42Q77@68525|delta/epsilon subdivisions,2YMR9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	Sulfite reductase beta subunit (hemoprotein)	-	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr,TusA
MMS1_k127_182779_1	1195236.CTER_3123	3.897e-145	476.0	COG0175@1|root,COG0175@2|Bacteria,1U1VN@1239|Firmicutes,248Y9@186801|Clostridia,3WJJK@541000|Ruminococcaceae	186801|Clostridia	EH	PFAM Phosphoadenosine phosphosulfate reductase	cysD	-	1.8.4.10,1.8.4.8,2.7.7.4	ko:K00390,ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R02021,R04929	RC00007,RC02809,RC02862,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
MMS1_k127_182779_0	1195236.CTER_3122	4.486e-236	743.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1TQXK@1239|Firmicutes,25EK3@186801|Clostridia,3WISI@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D3
MMS1_k127_182779_3	756499.Desde_1305	1.708e-31	127.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,260CU@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase
MMS1_k127_1831602_1	665571.STHERM_c01840	2.266e-186	589.0	COG0133@1|root,COG0133@2|Bacteria,2J5J8@203691|Spirochaetes	203691|Spirochaetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS1_k127_1831602_5	1480694.DC28_10225	2.17e-141	463.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2J5XH@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the	trpF	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
MMS1_k127_1831602_0	1480694.DC28_10220	9.456e-205	649.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,2J59H@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,Glycos_trans_3N,Glycos_transf_3
MMS1_k127_1831602_2	889378.Spiaf_2551	5.445e-186	593.0	COG0147@1|root,COG0147@2|Bacteria,2J5PF@203691|Spirochaetes	203691|Spirochaetes	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
MMS1_k127_1831602_9	1232683.ADIMK_0673	2.364e-39	149.0	COG3323@1|root,COG3323@2|Bacteria,1MZF5@1224|Proteobacteria,1S8WV@1236|Gammaproteobacteria,467S4@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K11022	ko05134,map05134	-	-	-	ko00000,ko00001,ko02042	-	-	-	-
MMS1_k127_1831602_7	1123274.KB899407_gene165	1.162e-70	250.0	COG1281@1|root,COG1281@2|Bacteria,2J58S@203691|Spirochaetes	203691|Spirochaetes	O	COGs COG1281 Disulfide bond chaperones of the HSP33 family	-	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
MMS1_k127_1831602_6	1121405.dsmv_1473	5.38e-100	350.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MPPV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
MMS1_k127_1831602_3	335543.Sfum_3244	1.771e-177	566.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMS1_k127_1831602_4	880073.Calab_2356	3.127e-152	508.0	COG0574@1|root,COG0574@2|Bacteria,2NQHP@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
MMS1_k127_1831602_8	1319815.HMPREF0202_00211	5.041e-55	200.0	COG0622@1|root,COG0622@2|Bacteria,379XS@32066|Fusobacteria	32066|Fusobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
MMS1_k127_1831983_1	1123274.KB899409_gene441	1.43e-102	351.0	COG4232@1|root,COG4232@2|Bacteria,2JAQC@203691|Spirochaetes	203691|Spirochaetes	CO	Disulphide bond corrector protein DsbC	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
MMS1_k127_1831983_0	1168289.AJKI01000056_gene3058	2.767e-113	382.0	COG0840@1|root,COG0840@2|Bacteria,4NIJR@976|Bacteroidetes	976|Bacteroidetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE3,HAMP,MCPsignal
MMS1_k127_1832306_0	889378.Spiaf_1044	9.24e-61	230.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,Hemerythrin,MCPsignal,dCache_1
MMS1_k127_1832572_0	1123274.KB899428_gene1832	0.0	1223.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J5JP@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS1_k127_1832572_1	573413.Spirs_1718	4.443e-253	791.0	COG0488@1|root,COG0488@2|Bacteria,2J5P1@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
MMS1_k127_1833627_0	243231.GSU0545	1.736e-15	82.0	COG0697@1|root,COG0697@2|Bacteria,1N024@1224|Proteobacteria,42NW9@68525|delta/epsilon subdivisions,2WJEJ@28221|Deltaproteobacteria,43UB5@69541|Desulfuromonadales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1833627_1	1128421.JAGA01000002_gene171	1.949e-12	80.0	COG3428@1|root,COG3428@2|Bacteria,2NS34@2323|unclassified Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	PASTA,bPH_2
MMS1_k127_1833627_2	57918.XP_004294393.1	3.261e-05	50.0	KOG2390@1|root,KOG2390@2759|Eukaryota,37P0P@33090|Viridiplantae,3G7V2@35493|Streptophyta,4JKKE@91835|fabids	35493|Streptophyta	S	Rab3 GTPase-activating protein catalytic	-	-	-	ko:K18270	-	-	-	-	ko00000,ko04131,ko04147	-	-	-	BSD,Rab3-GTPase_cat
MMS1_k127_1836258_0	1121335.Clst_1342	1.591e-186	595.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,3WP93@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_1836258_1	243233.MCA2479	1.581e-146	475.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1XE74@135618|Methylococcales	135618|Methylococcales	C	decarboxylase, beta subunit	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
MMS1_k127_1836258_2	634498.mru_0095	3.458e-54	198.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y6XE@28890|Euryarchaeota,23PT0@183925|Methanobacteria	183925|Methanobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
MMS1_k127_1837742_0	1287116.X734_10190	2.532e-08	66.0	COG5497@1|root,COG5497@2|Bacteria,1RCFU@1224|Proteobacteria,2U57W@28211|Alphaproteobacteria,43HBZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	secreted protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2259
MMS1_k127_1838759_3	1229276.DI53_3247	2.935e-06	51.0	COG1595@1|root,COG1595@2|Bacteria,4NN4K@976|Bacteroidetes,1IT6N@117747|Sphingobacteriia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	fecI	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
MMS1_k127_1838759_2	760192.Halhy_4719	1.56e-43	168.0	COG1409@1|root,COG1409@2|Bacteria,4NMZ0@976|Bacteroidetes,1IZFW@117747|Sphingobacteriia	976|Bacteroidetes	S	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos,Metallophos_2
MMS1_k127_1838759_1	1408422.JHYF01000010_gene3323	2.773e-67	235.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia,36HGP@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS1_k127_1838759_0	1123274.KB899430_gene1685	8.44e-83	279.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS1_k127_183946_0	889378.Spiaf_0706	1.834e-83	291.0	COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,2J7X4@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator sugar kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR,ROK
MMS1_k127_183946_3	869213.JCM21142_134805	1.042e-46	178.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
MMS1_k127_183946_2	1348635.BBJY01000003_gene3894	1.832e-60	213.0	COG1335@1|root,COG1335@2|Bacteria,1REQ3@1224|Proteobacteria,1SAXP@1236|Gammaproteobacteria,1XWGQ@135623|Vibrionales	135623|Vibrionales	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS1_k127_183946_1	646529.Desaci_1485	4.014e-67	234.0	COG0778@1|root,COG0778@2|Bacteria,1V9VR@1239|Firmicutes,24Q35@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_183946_4	113355.CM001775_gene2564	5.814e-37	142.0	COG4679@1|root,COG4679@2|Bacteria,1GDRR@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
MMS1_k127_183946_5	869209.Tresu_0786	3.014e-22	98.0	COG1396@1|root,COG1396@2|Bacteria,2J99Y@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
MMS1_k127_1842029_0	889378.Spiaf_1341	2.422e-83	300.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K11021	-	-	-	-	ko00000,ko02042	-	-	-	RHS_repeat
MMS1_k127_1842955_1	1196028.ALEF01000016_gene2686	1.506e-05	47.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4HAQD@91061|Bacilli,4C56K@84406|Virgibacillus	91061|Bacilli	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
MMS1_k127_1842955_0	573413.Spirs_3789	2.751e-62	223.0	COG1876@1|root,COG1876@2|Bacteria,2J72U@203691|Spirochaetes	203691|Spirochaetes	M	Carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
MMS1_k127_1842955_2	926550.CLDAP_07830	0.0004054	48.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
MMS1_k127_1843219_4	502025.Hoch_5143	1.328e-06	51.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,Phosphonate-bd,Response_reg
MMS1_k127_1843219_1	1121413.JMKT01000008_gene1138	1.601e-169	546.0	COG0318@1|root,COG0318@2|Bacteria,1QVGC@1224|Proteobacteria,43BUA@68525|delta/epsilon subdivisions	1224|Proteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding
MMS1_k127_1843219_0	1123274.KB899406_gene1191	9.329e-191	609.0	COG4231@1|root,COG4231@2|Bacteria,2J5C0@203691|Spirochaetes	203691|Spirochaetes	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C
MMS1_k127_1843219_2	545695.TREAZ_3595	5.621e-61	215.0	COG1014@1|root,COG1014@2|Bacteria,2J7I3@203691|Spirochaetes	203691|Spirochaetes	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
MMS1_k127_1843219_3	771875.Ferpe_0345	8.728e-17	84.0	COG0280@1|root,COG0280@2|Bacteria,2GC4Q@200918|Thermotogae	200918|Thermotogae	C	PFAM Phosphate acetyl butaryl transferase	-	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
MMS1_k127_1843741_2	857293.CAAU_1576	6.092e-32	128.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,36F7D@31979|Clostridiaceae	186801|Clostridia	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
MMS1_k127_1843741_1	1341151.ASZU01000008_gene1402	2.236e-90	303.0	COG5012@1|root,COG5012@2|Bacteria,1UJB2@1239|Firmicutes,4HBJ7@91061|Bacilli,27B4I@186824|Thermoactinomycetaceae	91061|Bacilli	S	Dimerisation domain of d-ornithine 4,5-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,OAM_dimer
MMS1_k127_1843741_0	561177.ANHYDRO_01105	3.427e-147	478.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,22GK8@1570339|Peptoniphilaceae	186801|Clostridia	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_1845963_0	573413.Spirs_0856	8.982e-107	353.0	COG0514@1|root,COG0514@2|Bacteria,2J602@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
MMS1_k127_1848415_4	589865.DaAHT2_0221	2.487e-19	103.0	COG2172@1|root,COG2208@1|root,COG5002@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG5002@2|Bacteria,1PGCN@1224|Proteobacteria,42ZJ2@68525|delta/epsilon subdivisions,2WUYN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Stage II sporulation E family protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
MMS1_k127_1848415_0	573370.DMR_29870	1.579e-118	406.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MG79@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	SMART chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,HBM,MCPsignal
MMS1_k127_1848415_2	1049564.TevJSym_aa01000	1.917e-32	138.0	COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,1S26J@1236|Gammaproteobacteria,1J6PS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NT	Two component signalling adaptor domain	cheW-2	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_1848415_5	1321815.HMPREF9193_00821	0.0003054	47.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
MMS1_k127_1848415_1	941449.dsx2_1856	5.694e-91	311.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2M8VE@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_1848415_3	889378.Spiaf_1868	1.294e-19	91.0	COG1352@1|root,COG1352@2|Bacteria,2J7GX@203691|Spirochaetes	203691|Spirochaetes	NT	CheR methyltransferase, SAM binding domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
MMS1_k127_184903_2	1250005.PHEL85_3096	4.617e-32	130.0	COG0454@1|root,COG0456@2|Bacteria,4NTYJ@976|Bacteroidetes,1I49X@117743|Flavobacteriia,3VXAY@52959|Polaribacter	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
MMS1_k127_184903_1	586413.CCDL010000001_gene444	4.326e-40	154.0	COG1670@1|root,COG1670@2|Bacteria,1V1EW@1239|Firmicutes,4HFJJ@91061|Bacilli,23KRW@182709|Oceanobacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
MMS1_k127_184903_3	656024.FsymDg_4095	2.191e-11	70.0	COG0454@1|root,COG0454@2|Bacteria,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4ESJ5@85013|Frankiales	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
MMS1_k127_184903_5	7739.XP_002585923.1	2.632e-05	56.0	KOG1217@1|root,KOG3544@1|root,KOG4297@1|root,KOG1217@2759|Eukaryota,KOG3544@2759|Eukaryota,KOG4297@2759|Eukaryota,38DGH@33154|Opisthokonta,3BA28@33208|Metazoa,3CSUY@33213|Bilateria,4858V@7711|Chordata	33208|Metazoa	W	biological adhesion	COL6A6	GO:0005575,GO:0005576,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030198,GO:0031012,GO:0032991,GO:0043062,GO:0043933,GO:0044085,GO:0044421,GO:0051259,GO:0051291,GO:0065003,GO:0070206,GO:0070208,GO:0071840	-	ko:K06236,ko:K06238,ko:K19720	ko04151,ko04510,ko04512,ko04611,ko04926,ko04933,ko04974,ko05146,ko05165,map04151,map04510,map04512,map04611,map04926,map04933,map04974,map05146,map05165	-	-	-	ko00000,ko00001,ko00536,ko04147,ko04516	-	-	-	Collagen,Kunitz_BPTI,VWA
MMS1_k127_184903_0	573413.Spirs_0663	9.938e-84	278.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
MMS1_k127_184903_4	1307761.L21SP2_1533	1.528e-10	64.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS1_k127_1850453_0	1121403.AUCV01000017_gene4460	4.597e-88	293.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2WNT4@28221|Deltaproteobacteria,2MPWK@213118|Desulfobacterales	28221|Deltaproteobacteria	O	C-terminal domain of 1-Cys peroxiredoxin	prx-2	-	1.11.1.15	ko:K03386,ko:K20011	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
MMS1_k127_1850453_1	82996.sch_18660	1.287e-75	271.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RMQ0@1236|Gammaproteobacteria,401RE@613|Serratia	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	2.6.1.103	ko:K05825,ko:K16423	ko00261,ko00300,ko01055,ko01100,ko01130,ko01210,map00261,map00300,map01055,map01100,map01130,map01210	-	R01939,R06626,R06634	RC00006,RC01104	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,GntR
MMS1_k127_1853539_0	573413.Spirs_2051	2.533e-163	521.0	COG0468@1|root,COG0468@2|Bacteria,2J5G5@203691|Spirochaetes	203691|Spirochaetes	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
MMS1_k127_1853539_1	37659.JNLN01000001_gene1526	1.919e-10	64.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
MMS1_k127_1855490_0	1168034.FH5T_08755	1.354e-188	595.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,2FM0N@200643|Bacteroidia	976|Bacteroidetes	E	8-amino-7-oxononanoate synthase	kbl	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_1855490_3	1223544.GSI01S_06_00280	8.487e-10	66.0	COG3247@1|root,COG3247@2|Bacteria,2H3AT@201174|Actinobacteria,4GEAD@85026|Gordoniaceae	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
MMS1_k127_1855490_1	1123274.KB899409_gene620	1.024e-90	310.0	COG2203@1|root,COG2208@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3850@2|Bacteria,2J5K8@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
MMS1_k127_1859165_2	1123308.KB904550_gene460	0.0001924	46.0	COG0444@1|root,COG0444@2|Bacteria,1VUQ6@1239|Firmicutes,4HU7K@91061|Bacilli	91061|Bacilli	EP	abc transporter atp-binding protein	nikD	-	3.6.3.24	ko:K15587	ko02010,map02010	M00440	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5	-	-	ABC_tran
MMS1_k127_1859165_0	573413.Spirs_1733	7.117e-74	261.0	COG1463@1|root,COG1463@2|Bacteria,2J7MR@203691|Spirochaetes	203691|Spirochaetes	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
MMS1_k127_1859165_1	744872.Spica_2753	3.262e-08	63.0	COG0457@1|root,COG0457@2|Bacteria,2J8XX@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_8
MMS1_k127_1860850_0	573413.Spirs_4004	1.278e-284	884.0	COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes	203691|Spirochaetes	L	DNA topoisomerase	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS1_k127_1860850_1	1480694.DC28_14615	6.767e-204	645.0	COG0188@1|root,COG0188@2|Bacteria,2J5Y9@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the type II topoisomerase GyrA ParC subunit family	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
MMS1_k127_1861415_0	744872.Spica_1520	1.462e-121	404.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
MMS1_k127_1861415_2	1123274.KB899413_gene829	3.843e-12	70.0	29A3I@1|root,2ZX4S@2|Bacteria,2J8Z8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1861415_1	1499683.CCFF01000017_gene2897	1.351e-49	180.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,36DJ7@31979|Clostridiaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS1_k127_1866154_0	744872.Spica_0779	2.206e-42	173.0	2F10I@1|root,33U21@2|Bacteria,2J5K0@203691|Spirochaetes	203691|Spirochaetes	S	Family of unknown function (DUF5312)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
MMS1_k127_1871411_0	1307761.L21SP2_2290	2.113e-111	376.0	COG1032@1|root,COG1032@2|Bacteria,2J66V@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4080,Radical_SAM
MMS1_k127_1871411_1	545695.TREAZ_0479	1.71e-24	103.0	COG0809@1|root,COG0809@2|Bacteria,2J5HY@203691|Spirochaetes	203691|Spirochaetes	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMS1_k127_1871681_3	871968.DESME_06030	3.781e-06	49.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,260XY@186807|Peptococcaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMS1_k127_1871681_1	1168034.FH5T_19385	1.455e-89	312.0	COG2271@1|root,COG2271@2|Bacteria,4NF82@976|Bacteroidetes	976|Bacteroidetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1871681_0	1121403.AUCV01000013_gene3920	7.121e-120	402.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MID@68525|delta/epsilon subdivisions,2WJYT@28221|Deltaproteobacteria,2MMWN@213118|Desulfobacterales	28221|Deltaproteobacteria	EK	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
MMS1_k127_1871681_2	1122621.ATZA01000039_gene2637	6.439e-46	170.0	COG2114@1|root,COG4191@1|root,COG2114@2|Bacteria,COG4191@2|Bacteria,4NEVN@976|Bacteroidetes,1IS6A@117747|Sphingobacteriia	976|Bacteroidetes	T	PFAM Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,Reg_prop,Response_reg,Y_Y_Y
MMS1_k127_1872881_0	1123274.KB899452_gene2704	8.208e-71	249.0	COG0697@1|root,COG0697@2|Bacteria,2JAAC@203691|Spirochaetes	203691|Spirochaetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1874766_4	1158294.JOMI01000003_gene2333	1.647e-63	225.0	COG0637@1|root,COG0637@2|Bacteria,4NP99@976|Bacteroidetes,2FMC0@200643|Bacteroidia	976|Bacteroidetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMS1_k127_1874766_0	420246.GTNG_0403	1.885e-175	561.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,4H9VV@91061|Bacilli,1WFNE@129337|Geobacillus	91061|Bacilli	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1874766_3	641107.CDLVIII_2883	1.214e-64	227.0	COG1309@1|root,COG1309@2|Bacteria,1VJ93@1239|Firmicutes,24IHU@186801|Clostridia,36MXQ@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1874766_1	485913.Krac_2243	5.158e-79	275.0	COG2378@1|root,COG2378@2|Bacteria	2|Bacteria	K	regulation of single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
MMS1_k127_1874766_2	246197.MXAN_4991	9.693e-78	268.0	COG0596@1|root,COG0596@2|Bacteria,1R4N4@1224|Proteobacteria,434SV@68525|delta/epsilon subdivisions,2WZ3Y@28221|Deltaproteobacteria,2Z19T@29|Myxococcales	28221|Deltaproteobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
MMS1_k127_1875013_4	398767.Glov_3572	6.228e-16	79.0	COG1487@1|root,COG1487@2|Bacteria,1N44Q@1224|Proteobacteria,42UNG@68525|delta/epsilon subdivisions,2WRVS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS1_k127_1875013_1	536227.CcarbDRAFT_3240	6.509e-183	583.0	COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,36DFN@31979|Clostridiaceae	186801|Clostridia	G	glucuronate isomerase	uxaC	-	5.3.1.12	ko:K01812	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	UxaC
MMS1_k127_1875013_3	665571.STHERM_c04590	1.55e-90	305.0	COG1028@1|root,COG1028@2|Bacteria,2JA2I@203691|Spirochaetes	203691|Spirochaetes	C	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS1_k127_1875013_2	1168289.AJKI01000036_gene3415	1.086e-176	565.0	COG3875@1|root,COG3875@2|Bacteria,4NI4Z@976|Bacteroidetes,2FQM8@200643|Bacteroidia,3XJV1@558415|Marinilabiliaceae	976|Bacteroidetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
MMS1_k127_1875013_0	1307761.L21SP2_0498	7.399e-221	691.0	COG0362@1|root,COG0362@2|Bacteria,2J661@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
MMS1_k127_1876320_4	383372.Rcas_2912	7.168e-06	48.0	COG0714@1|root,COG0714@2|Bacteria,2G8BI@200795|Chloroflexi,377XH@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_1876320_3	357808.RoseRS_3183	1.059e-66	244.0	COG1721@1|root,COG1721@2|Bacteria,2G7JJ@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_1876320_0	935837.JAEK01000010_gene12	1.561e-148	480.0	COG1680@1|root,COG1680@2|Bacteria,1U828@1239|Firmicutes,4HA0Q@91061|Bacilli,1ZBJ0@1386|Bacillus	91061|Bacilli	V	Belongs to the UPF0214 family	ybbE	-	3.4.16.4	ko:K21469	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase,Peptidase_M6
MMS1_k127_1876320_1	1307761.L21SP2_3465	2.214e-146	472.0	COG0667@1|root,COG0667@2|Bacteria,2J6C3@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Aldo keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
MMS1_k127_1876320_2	717606.PaecuDRAFT_1789	3.263e-79	272.0	COG0789@1|root,COG0789@2|Bacteria,1TS6Z@1239|Firmicutes,4HCVW@91061|Bacilli,26S0U@186822|Paenibacillaceae	91061|Bacilli	K	MerR family transcriptional regulator	mta	-	-	ko:K21743	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1,TipAS
MMS1_k127_1876763_2	760011.Spico_0596	8.411e-31	127.0	COG0130@1|root,COG0130@2|Bacteria,2J7Q2@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
MMS1_k127_1876763_1	1123274.KB899421_gene1762	3.688e-31	124.0	COG0184@1|root,COG0184@2|Bacteria,2J91K@203691|Spirochaetes	203691|Spirochaetes	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
MMS1_k127_1876763_0	1307761.L21SP2_1809	6.052e-114	376.0	COG1185@1|root,COG1185@2|Bacteria,2J5BU@203691|Spirochaetes	203691|Spirochaetes	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
MMS1_k127_1877831_0	1539298.JO41_07265	8.557e-256	839.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
MMS1_k127_1878793_3	1123288.SOV_1c03730	8.932e-52	189.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4H1UN@909932|Negativicutes	909932|Negativicutes	EGP	Transporter major facilitator family protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_1878793_7	290402.Cbei_3916	1.611e-12	74.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,36E4X@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_1878793_8	562743.JH976434_gene1833	2.885e-08	56.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
MMS1_k127_1878793_6	545695.TREAZ_2219	3.894e-28	116.0	COG1396@1|root,COG1396@2|Bacteria,2JASW@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1878793_0	1392489.JPOL01000002_gene2656	5.862e-163	526.0	COG3550@1|root,COG3550@2|Bacteria,4NFYY@976|Bacteroidetes,1HXAI@117743|Flavobacteriia,2XJUT@283735|Leeuwenhoekiella	976|Bacteroidetes	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
MMS1_k127_1878793_1	573413.Spirs_3338	4.071e-154	491.0	COG0667@1|root,COG0667@2|Bacteria,2J8MY@203691|Spirochaetes	203691|Spirochaetes	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_1878793_2	768706.Desor_1825	8.608e-149	473.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,263XK@186807|Peptococcaceae	186801|Clostridia	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_1878793_5	1304865.JAGF01000001_gene31	1.482e-31	129.0	COG1472@1|root,COG1472@2|Bacteria,2GQQR@201174|Actinobacteria,4F1SA@85016|Cellulomonadaceae	201174|Actinobacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_1878793_4	744872.Spica_0095	4.397e-36	141.0	COG1373@1|root,COG1373@2|Bacteria,2J5MK@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_1879609_0	643867.Ftrac_3140	1.033e-51	188.0	COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,47JC5@768503|Cytophagia	976|Bacteroidetes	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
MMS1_k127_1879609_2	744872.Spica_1489	3.289e-09	65.0	28YH3@1|root,2ZKB9@2|Bacteria,2J8G8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1879609_1	1480694.DC28_00445	2.271e-40	153.0	2EET3@1|root,338KM@2|Bacteria,2J87J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1879609_3	1480694.DC28_11670	3.735e-06	52.0	28UIX@1|root,2ZGPI@2|Bacteria,2JB2W@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1883506_1	675814.VIC_003443	6.542e-25	120.0	COG4191@1|root,COG4564@1|root,COG4191@2|Bacteria,COG4564@2|Bacteria,1RCM9@1224|Proteobacteria,1RN52@1236|Gammaproteobacteria,1XTD4@135623|Vibrionales	135623|Vibrionales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,dCache_2
MMS1_k127_1883506_0	484770.UFO1_2046	8.815e-99	332.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,4H5RJ@909932|Negativicutes	909932|Negativicutes	G	PFAM Periplasmic binding protein domain	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
MMS1_k127_1884167_2	573413.Spirs_3153	8.418e-75	255.0	COG0162@1|root,COG0162@2|Bacteria,2J5ZS@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
MMS1_k127_1884167_0	221027.JO40_05415	3.348e-228	714.0	COG0423@1|root,COG0423@2|Bacteria,2J57N@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMS1_k127_1884167_1	573413.Spirs_3155	1.393e-207	655.0	COG0008@1|root,COG0008@2|Bacteria,2J5M7@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
MMS1_k127_1884167_3	485916.Dtox_1577	5.11e-34	142.0	COG2199@1|root,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,249J7@186801|Clostridia,261UM@186807|Peptococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
MMS1_k127_1887108_1	246194.CHY_0732	1.03e-218	686.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,42EM7@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
MMS1_k127_1887108_0	903818.KI912268_gene1122	7.265e-304	955.0	COG3383@1|root,COG3383@2|Bacteria,3Y2KP@57723|Acidobacteria	57723|Acidobacteria	C	Formate dehydrogenase, alpha subunit	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS1_k127_1887108_3	86416.Clopa_0275	6.706e-36	144.0	2E19M@1|root,32WPW@2|Bacteria,1VCY5@1239|Firmicutes,24I3Z@186801|Clostridia,36IZS@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1887108_2	889378.Spiaf_1165	1.501e-68	258.0	COG2199@1|root,COG2199@2|Bacteria,2J8G2@203691|Spirochaetes	203691|Spirochaetes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_1888957_1	907348.TresaDRAFT_1103	1.029e-70	263.0	COG0457@1|root,COG0457@2|Bacteria,2J5SR@203691|Spirochaetes	203691|Spirochaetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_6,TPR_8
MMS1_k127_1888957_0	158190.SpiGrapes_0358	6.835e-162	514.0	COG0057@1|root,COG0057@2|Bacteria,2J5AD@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
MMS1_k127_1888957_2	573413.Spirs_2444	5.267e-63	220.0	COG0126@1|root,COG0126@2|Bacteria,2J68Y@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS1_k127_1889847_3	1123274.KB899406_gene1156	2.885e-154	495.0	COG1172@1|root,COG1172@2|Bacteria,2J78F@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_1889847_4	1125725.HMPREF1325_0478	2.697e-150	484.0	COG1172@1|root,COG1172@2|Bacteria,2J781@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_1889847_0	1125725.HMPREF1325_0477	1.139e-239	749.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
MMS1_k127_1889847_1	1123274.KB899406_gene1153	2.29e-166	527.0	COG1879@1|root,COG1879@2|Bacteria,2J6JD@203691|Spirochaetes	203691|Spirochaetes	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
MMS1_k127_1889847_2	158190.SpiGrapes_2790	4.708e-165	534.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J60C@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1894795_0	1232410.KI421421_gene3691	0.0	1776.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,43BKE@68525|delta/epsilon subdivisions,2X6YE@28221|Deltaproteobacteria,43S2W@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Biotin carboxylase C-terminal domain	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
MMS1_k127_1894795_1	936053.I1BXE1	1.697e-50	183.0	COG4702@1|root,2S03S@2759|Eukaryota,3A2EM@33154|Opisthokonta,3P3CR@4751|Fungi,1GU87@112252|Fungi incertae sedis	4751|Fungi	S	Haem-degrading	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006620,GO:0006810,GO:0006886,GO:0006996,GO:0007029,GO:0008104,GO:0008150,GO:0009987,GO:0010256,GO:0015031,GO:0015833,GO:0016043,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0061024,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071840,GO:0072379,GO:0072380,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0090158	-	-	-	-	-	-	-	-	-	-	Haem_degrading
MMS1_k127_1894795_2	1214065.BAGV01000031_gene790	8.631e-27	111.0	COG4628@1|root,COG4628@2|Bacteria,1N7DG@1224|Proteobacteria,1SCBE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	conserved protein	-	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	VF530
MMS1_k127_1894795_3	622312.ROSEINA2194_04061	0.0005446	45.0	COG0583@1|root,COG0583@2|Bacteria,1V1ND@1239|Firmicutes,25C6Z@186801|Clostridia	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1899352_0	665571.STHERM_c01160	5.988e-94	334.0	COG0643@1|root,COG0643@2|Bacteria,2J9VU@203691|Spirochaetes	203691|Spirochaetes	NT	Signal transducing histidine kinase, homodimeric domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
MMS1_k127_1900037_1	742740.HMPREF9474_04268	8.666e-61	215.0	COG1879@1|root,COG1879@2|Bacteria,1TQ95@1239|Firmicutes,24AX7@186801|Clostridia,21Y69@1506553|Lachnoclostridium	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_1900037_0	485918.Cpin_6614	1.445e-90	305.0	COG1418@1|root,COG1418@2|Bacteria,4NEZY@976|Bacteroidetes,1IR7H@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMS1_k127_1900037_3	477974.Daud_0138	2.336e-12	74.0	COG2199@1|root,COG2206@1|root,COG3290@1|root,COG3829@1|root,COG4936@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4936@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,267B5@186807|Peptococcaceae	186801|Clostridia	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9
MMS1_k127_1900489_1	1265505.ATUG01000002_gene1530	1.938e-112	368.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MID@68525|delta/epsilon subdivisions,2WJYT@28221|Deltaproteobacteria,2MISG@213118|Desulfobacterales	28221|Deltaproteobacteria	EK	PFAM aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
MMS1_k127_1900489_2	1121396.KB893105_gene1816	4.845e-104	346.0	COG0697@1|root,COG0697@2|Bacteria,1PYYX@1224|Proteobacteria,435M7@68525|delta/epsilon subdivisions,2X002@28221|Deltaproteobacteria,2MMU4@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_1900489_3	1117318.PRUB_09164	6.069e-27	122.0	COG2706@1|root,COG4676@1|root,COG2706@2|Bacteria,COG4676@2|Bacteria,1MYHN@1224|Proteobacteria,1S7IE@1236|Gammaproteobacteria,2Q4PF@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1900489_4	1410624.JNKK01000018_gene2016	4.663e-22	107.0	2EAEX@1|root,334ID@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1900489_0	1121403.AUCV01000013_gene3898	2.969e-113	381.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_1901254_4	573413.Spirs_3827	5.534e-30	121.0	COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
MMS1_k127_1901254_2	545694.TREPR_3794	9.946e-48	179.0	COG0357@1|root,COG0357@2|Bacteria,2J72Y@203691|Spirochaetes	203691|Spirochaetes	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
MMS1_k127_1901254_0	665571.STHERM_c02920	2.061e-252	793.0	COG0445@1|root,COG0445@2|Bacteria,2J5A1@203691|Spirochaetes	203691|Spirochaetes	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
MMS1_k127_1901254_1	1123274.KB899410_gene3459	5.34e-138	452.0	COG0486@1|root,COG0486@2|Bacteria,2J5GU@203691|Spirochaetes	203691|Spirochaetes	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
MMS1_k127_1901254_3	158190.SpiGrapes_2492	1.582e-43	164.0	COG0584@1|root,COG0584@2|Bacteria,2J6RW@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
MMS1_k127_1901828_1	1117318.PRUB_05786	5.312e-17	83.0	COG1051@1|root,COG1051@2|Bacteria,1NA5A@1224|Proteobacteria,1SFGB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_1901828_0	517418.Ctha_1907	2.355e-218	706.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	pqqL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS1_k127_1902416_3	1307761.L21SP2_2777	3.263e-12	75.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	5.99.1.3	ko:K02470,ko:K03833	-	-	-	-	ko00000,ko01000,ko03012,ko03032,ko03400	-	-	-	HATPase_c,HTH_20
MMS1_k127_1902416_1	580340.Tlie_0017	1.34e-34	138.0	COG0701@1|root,COG0701@2|Bacteria,3TBTB@508458|Synergistetes	508458|Synergistetes	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1902416_0	580340.Tlie_0018	2.933e-37	152.0	COG0701@1|root,COG0701@2|Bacteria,3TBKV@508458|Synergistetes	508458|Synergistetes	S	Predicted permease	-	-	-	-	-	-	-	-	-	-	-	-	ArsP_1
MMS1_k127_1902416_2	913865.DOT_5174	1.029e-22	102.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
MMS1_k127_1902416_4	665571.STHERM_c17700	2.28e-06	51.0	COG0508@1|root,COG0508@2|Bacteria,2J5U3@203691|Spirochaetes	203691|Spirochaetes	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
MMS1_k127_1909929_1	530564.Psta_3290	4.405e-15	83.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
MMS1_k127_1909929_0	935837.JAEK01000066_gene3962	3.367e-242	773.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,4HBKW@91061|Bacilli,1ZCQ6@1386|Bacillus	91061|Bacilli	G	Glycosyl hydrolases family 2	-	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_1911271_3	1499968.TCA2_5157	0.0001273	45.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V4UB@1239|Firmicutes,4HDDC@91061|Bacilli,26QY9@186822|Paenibacillaceae	91061|Bacilli	T	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_1911271_0	744872.Spica_2245	3.276e-57	203.0	COG4154@1|root,COG4154@2|Bacteria,2J8CF@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the RbsD FucU family	-	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
MMS1_k127_1911271_2	665956.HMPREF1032_00802	5.284e-30	124.0	COG0346@1|root,COG0346@2|Bacteria,1V7XP@1239|Firmicutes,24KYI@186801|Clostridia,3WKCC@541000|Ruminococcaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
MMS1_k127_1911271_1	158190.SpiGrapes_3252	2.818e-37	143.0	COG0667@1|root,COG0667@2|Bacteria,2J6C3@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Aldo keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
MMS1_k127_1911338_5	1047013.AQSP01000113_gene743	9.018e-13	70.0	COG3225@1|root,COG3225@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
MMS1_k127_1911338_1	1047013.AQSP01000113_gene744	2.312e-75	262.0	COG1277@1|root,COG1277@2|Bacteria,2NPGK@2323|unclassified Bacteria	2|Bacteria	S	ABC-2 family transporter protein	gldF	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux
MMS1_k127_1911338_0	933262.AXAM01000016_gene190	1.632e-99	336.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2MI4N@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_1911338_2	1094508.Tsac_2397	4.887e-26	110.0	COG0526@1|root,COG0526@2|Bacteria,1VFUD@1239|Firmicutes,24R4Y@186801|Clostridia,42GTW@68295|Thermoanaerobacterales	186801|Clostridia	CO	PFAM Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
MMS1_k127_1911338_3	1291050.JAGE01000001_gene1602	1.198e-22	101.0	2C1T4@1|root,336EA@2|Bacteria,1VVT5@1239|Firmicutes,24J1U@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1911338_4	697303.Thewi_2496	7.995e-18	88.0	COG0249@1|root,COG0249@2|Bacteria,1UYBJ@1239|Firmicutes,249T9@186801|Clostridia,42HQ4@68295|Thermoanaerobacterales	186801|Clostridia	L	SMART DNA mismatch repair protein MutS, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
MMS1_k127_1913361_1	1123274.KB899417_gene2082	3.995e-118	384.0	COG1175@1|root,COG1175@2|Bacteria,2J82P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1913361_2	1480694.DC28_13725	1.299e-96	330.0	COG0395@1|root,COG0395@2|Bacteria,2JA2J@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1913361_0	1178825.ALIH01000006_gene1427	1.792e-157	514.0	COG1387@1|root,COG1387@2|Bacteria,4PFQB@976|Bacteroidetes,1I844@117743|Flavobacteriia	976|Bacteroidetes	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1913361_4	1450525.JATV01000001_gene2460	2.138e-28	120.0	COG2731@1|root,COG2731@2|Bacteria,4NTHU@976|Bacteroidetes,1IMH6@117743|Flavobacteriia,2P0BF@237|Flavobacterium	976|Bacteroidetes	G	Domain of unknown function (DUF386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
MMS1_k127_1913361_3	158190.SpiGrapes_2320	1.899e-83	295.0	COG2211@1|root,COG2211@2|Bacteria,2J6VC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter	-	-	-	ko:K11104,ko:K16209,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
MMS1_k127_1914318_0	906968.Trebr_0890	7.947e-159	507.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS1_k127_19152_0	1480694.DC28_11050	4.573e-106	362.0	COG1078@1|root,COG1078@2|Bacteria,2J64T@203691|Spirochaetes	203691|Spirochaetes	S	HD superfamily phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
MMS1_k127_19152_1	889378.Spiaf_2647	1.26e-74	254.0	COG2172@1|root,COG2172@2|Bacteria,2J5HH@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS
MMS1_k127_1915231_3	887327.HMPREF0476_1242	7.271e-40	167.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KQCT@206351|Neisseriales	206351|Neisseriales	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
MMS1_k127_1915231_1	744872.Spica_2332	1.369e-76	269.0	COG2815@1|root,COG2815@2|Bacteria,2J5J2@203691|Spirochaetes	203691|Spirochaetes	S	Pasta domain protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
MMS1_k127_1915231_0	573413.Spirs_1655	3.566e-85	292.0	COG0223@1|root,COG0223@2|Bacteria,2J621@203691|Spirochaetes	203691|Spirochaetes	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
MMS1_k127_1915231_2	744872.Spica_2334	6.423e-48	176.0	COG0242@1|root,COG0242@2|Bacteria,2J7X0@203691|Spirochaetes	203691|Spirochaetes	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
MMS1_k127_1915231_4	1089548.KI783301_gene1693	2.989e-29	121.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes	1239|Firmicutes	T	Histidine kinase	baeS	-	2.7.13.3	ko:K07642,ko:K10681	ko02020,map02020	M00450,M00468,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_1919873_2	81824.XP_001743354.1	2.343e-06	51.0	COG0385@1|root,KOG4821@2759|Eukaryota,38RUU@33154|Opisthokonta	33154|Opisthokonta	S	Solute carrier family 10, member 7	SLC10A7	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
MMS1_k127_1919873_0	929506.CbC4_1716	1.791e-49	183.0	COG1309@1|root,COG1309@2|Bacteria,1VG3M@1239|Firmicutes,25BA9@186801|Clostridia,36IYT@31979|Clostridiaceae	186801|Clostridia	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
MMS1_k127_1919873_1	457421.CBFG_02194	5.231e-13	77.0	COG0583@1|root,COG0583@2|Bacteria,1UQYS@1239|Firmicutes,24F8K@186801|Clostridia,26A38@186813|unclassified Clostridiales	186801|Clostridia	K	LysR substrate binding domain	-	-	-	ko:K11921	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1923437_2	545695.TREAZ_0907	1.3e-38	149.0	COG0770@1|root,COG0770@2|Bacteria,2J5GH@203691|Spirochaetes	203691|Spirochaetes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS1_k127_1923437_0	573413.Spirs_1548	2.708e-145	469.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
MMS1_k127_1923437_1	1307761.L21SP2_1159	1.932e-104	351.0	COG0772@1|root,COG0772@2|Bacteria,2J58T@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
MMS1_k127_1923450_2	449447.MAE_15960	1.852e-17	89.0	COG0484@1|root,COG0484@2|Bacteria,1G0V5@1117|Cyanobacteria	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	dnaJ3	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
MMS1_k127_1923450_0	744872.Spica_0660	2.234e-258	805.0	COG0205@1|root,COG0205@2|Bacteria,2J60A@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135	2.7.1.90	ko:K00895	ko00010,ko00030,ko00051,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map01100,map01110,map01120,map01130	-	R00764,R02073	RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
MMS1_k127_1923450_1	880073.Calab_0028	4.321e-90	306.0	COG0153@1|root,COG0153@2|Bacteria,2NNYM@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_N,GalKase_gal_bdg
MMS1_k127_1924928_0	1123274.KB899411_gene3178	4.36e-80	278.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_1924928_1	1380763.BG53_02360	1.447e-28	119.0	COG1653@1|root,COG1653@2|Bacteria,1UY8X@1239|Firmicutes,4HT5T@91061|Bacilli,26RVV@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
MMS1_k127_1931078_2	660470.Theba_2139	3.134e-68	247.0	COG1668@1|root,COG1668@2|Bacteria	2|Bacteria	CP	transmembrane transport	natB	-	-	ko:K01992,ko:K09696	ko02010,ko02020,map02010,map02020	M00253,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.115	-	iYO844.BSU02760	ABC2_membrane_2,ABC2_membrane_3,Abi
MMS1_k127_1931078_1	521045.Kole_1193	1.854e-72	252.0	COG4555@1|root,COG4555@2|Bacteria,2GDTQ@200918|Thermotogae	200918|Thermotogae	CP	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
MMS1_k127_1931078_0	945713.IALB_1037	7.183e-233	735.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria	2|Bacteria	E	Formiminotransferase domain	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
MMS1_k127_1931078_3	1307761.L21SP2_0492	2.22e-67	254.0	COG0840@1|root,COG0840@2|Bacteria	1307761.L21SP2_0492|-	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	-
MMS1_k127_1931078_4	1266914.ATUK01000013_gene1969	4.831e-08	64.0	COG0642@1|root,COG2206@1|root,COG2205@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria,1X2BG@135613|Chromatiales	135613|Chromatiales	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PAS_4
MMS1_k127_1931535_1	1480694.DC28_12695	1.781e-24	110.0	COG1596@1|root,COG1596@2|Bacteria,2J6A1@203691|Spirochaetes	203691|Spirochaetes	M	export protein	-	-	-	-	-	-	-	-	-	-	-	-	SLBB
MMS1_k127_1931535_0	906968.Trebr_0929	3.801e-34	145.0	COG3206@1|root,COG3206@2|Bacteria,2J5HM@203691|Spirochaetes	203691|Spirochaetes	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
MMS1_k127_1931652_0	526218.Sterm_0122	5.401e-125	415.0	COG3119@1|root,COG3119@2|Bacteria,378TS@32066|Fusobacteria	32066|Fusobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS1_k127_1931652_5	469616.FMAG_00504	7.354e-74	268.0	COG4692@1|root,COG4692@2|Bacteria,37CVM@32066|Fusobacteria	32066|Fusobacteria	G	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
MMS1_k127_1931652_4	935837.JAEK01000006_gene4236	1.991e-76	266.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,4HCEH@91061|Bacilli,1ZCMK@1386|Bacillus	91061|Bacilli	G	COG0395 ABC-type sugar transport system, permease component	amyC1	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1931652_3	935837.JAEK01000006_gene4235	1.057e-81	282.0	COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,4HCFJ@91061|Bacilli,1ZDIC@1386|Bacillus	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	amyD1	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1931652_2	935836.JAEL01000054_gene4860	1.038e-109	368.0	COG1653@1|root,COG1653@2|Bacteria,1TQHT@1239|Firmicutes,4HAH2@91061|Bacilli,1ZD76@1386|Bacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
MMS1_k127_1931652_1	1122214.AQWH01000002_gene4159	1.554e-116	387.0	COG0673@1|root,COG0673@2|Bacteria,1PHFG@1224|Proteobacteria,2V8DX@28211|Alphaproteobacteria,2PMAY@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_1931652_6	573413.Spirs_0641	2.293e-23	111.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	VVA0761	-	-	ko:K14057	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1932630_4	1123248.KB893314_gene3516	5.797e-30	121.0	COG0581@1|root,COG0581@2|Bacteria,4NGBA@976|Bacteroidetes,1IPR0@117747|Sphingobacteriia	976|Bacteroidetes	P	Phosphate transport system permease protein	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS1_k127_1932630_1	1122973.KB904239_gene519	6.452e-91	307.0	COG1117@1|root,COG1117@2|Bacteria,4NFAB@976|Bacteroidetes,2FMN7@200643|Bacteroidia,22XA4@171551|Porphyromonadaceae	976|Bacteroidetes	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS1_k127_1932630_2	324602.Caur_1278	3.562e-42	162.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	ntcA	-	-	ko:K01420,ko:K10716,ko:K10914,ko:K16922	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko01002,ko02000,ko03000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_1932630_6	1444712.BN1013_00882	4.07e-14	81.0	COG0526@1|root,COG0526@2|Bacteria,2JFZU@204428|Chlamydiae	204428|Chlamydiae	CO	Thioredoxin-like	dsbH	-	5.3.4.1	ko:K01829	-	-	-	-	ko00000,ko01000	-	-	-	Thioredoxin_2,Thioredoxin_7
MMS1_k127_1932630_0	1328313.DS2_15549	2.456e-165	530.0	COG0235@1|root,COG0235@2|Bacteria,1QR17@1224|Proteobacteria,1RTT2@1236|Gammaproteobacteria,46CAK@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
MMS1_k127_1932630_3	350058.Mvan_1927	6.724e-41	157.0	COG1309@1|root,COG1309@2|Bacteria,2GNHX@201174|Actinobacteria,239H6@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1934645_2	1123009.AUID01000009_gene488	7.279e-41	155.0	COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,249SD@186801|Clostridia,268FR@186813|unclassified Clostridiales	186801|Clostridia	C	Nitroreductase family	-	-	1.5.1.38	ko:K19285	ko00740,ko01100,map00740,map01100	-	R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
MMS1_k127_1934645_4	342949.PNA2_1074	3.002e-18	98.0	COG0840@1|root,arCOG02320@2157|Archaea,2XTG0@28890|Euryarchaeota,2436R@183968|Thermococci	183968|Thermococci	N	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_1934645_0	1321778.HMPREF1982_02407	4.081e-133	430.0	COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,248NF@186801|Clostridia	186801|Clostridia	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_1934645_5	1385420.FRA_35c07920	6.28e-11	68.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,460RN@72273|Thiotrichales	72273|Thiotrichales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
MMS1_k127_1934645_3	1007103.AFHW01000017_gene5760	4.654e-36	141.0	COG0454@1|root,COG0454@2|Bacteria,1W6JE@1239|Firmicutes,4I02D@91061|Bacilli,277JX@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
MMS1_k127_1934645_1	1307761.L21SP2_0594	9.745e-117	383.0	COG2217@1|root,COG2217@2|Bacteria,2J5T8@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS1_k127_1936229_3	573413.Spirs_1060	3.575e-64	232.0	COG4585@1|root,COG4585@2|Bacteria,2J6X4@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HisKA_3
MMS1_k127_1936229_4	573413.Spirs_1061	3.474e-61	218.0	COG2197@1|root,COG2197@2|Bacteria,2JAGN@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_1936229_0	158190.SpiGrapes_1840	1.198e-198	628.0	COG1653@1|root,COG1653@2|Bacteria,2JA5C@203691|Spirochaetes	203691|Spirochaetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_1936229_1	573413.Spirs_1063	3.539e-133	431.0	COG1175@1|root,COG1175@2|Bacteria,2J9TQ@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1936229_2	1307761.L21SP2_3395	2.888e-105	350.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	ycjP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_1938693_0	223926.28806900	7.396e-05	53.0	COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,1T1XV@1236|Gammaproteobacteria,1XUBC@135623|Vibrionales	135623|Vibrionales	T	Signal transduction histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,sCache_2
MMS1_k127_1939764_0	316067.Geob_0091	9.33e-109	363.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MB3@68525|delta/epsilon subdivisions,2WJHZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	DUF4172,Fic
MMS1_k127_1939764_1	102125.Xen7305DRAFT_00036690	1.131e-07	57.0	COG1669@1|root,COG1669@2|Bacteria,1G804@1117|Cyanobacteria,3VN2B@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
MMS1_k127_1945105_0	1511.CLOST_0198	3.916e-141	451.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia	186801|Clostridia	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
MMS1_k127_1945105_2	889378.Spiaf_1044	3.261e-38	162.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,Hemerythrin,MCPsignal,dCache_1
MMS1_k127_1947328_0	1499967.BAYZ01000155_gene652	4.749e-55	204.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	pfkB	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS1_k127_1947381_1	158189.SpiBuddy_1977	5.269e-32	126.0	COG0211@1|root,COG0211@2|Bacteria,2J967@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
MMS1_k127_1947381_3	545694.TREPR_3449	9.402e-14	77.0	COG2868@1|root,COG2868@2|Bacteria,2J8JE@203691|Spirochaetes	203691|Spirochaetes	J	Pfam:Peptidase_C108	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
MMS1_k127_1947381_2	869209.Tresu_0891	5.071e-29	118.0	COG0261@1|root,COG0261@2|Bacteria,2J7PP@203691|Spirochaetes	203691|Spirochaetes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
MMS1_k127_1947381_0	1123274.KB899415_gene2416	2.626e-91	305.0	COG0018@1|root,COG0018@2|Bacteria,2J5EP@203691|Spirochaetes	203691|Spirochaetes	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMS1_k127_1953702_0	1125701.HMPREF1221_01361	2.348e-87	329.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
MMS1_k127_1953702_2	1125701.HMPREF1221_01362	7.538e-23	107.0	28X12@1|root,2ZIZV@2|Bacteria,2J7JF@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1953702_1	665571.STHERM_c00580	2.248e-33	139.0	2FHV9@1|root,349NF@2|Bacteria,2J69K@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1955931_8	744872.Spica_1224	0.0009522	42.0	COG0726@1|root,COG0726@2|Bacteria,2J5Y1@203691|Spirochaetes	203691|Spirochaetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Polysacc_deac_1
MMS1_k127_1955931_4	744872.Spica_0452	1.141e-39	151.0	COG1516@1|root,COG1516@2|Bacteria,2J7XT@203691|Spirochaetes	203691|Spirochaetes	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
MMS1_k127_1955931_1	1313293.BAN_0060400	2.343e-225	727.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2J5FM@203691|Spirochaetes	203691|Spirochaetes	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
MMS1_k127_1955931_5	545695.TREAZ_2240	4.883e-39	152.0	COG0237@1|root,COG0237@2|Bacteria,2J810@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
MMS1_k127_1955931_7	744872.Spica_0448	8.793e-14	81.0	COG3087@1|root,COG3087@2|Bacteria,2J8S5@203691|Spirochaetes	203691|Spirochaetes	D	PFAM Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
MMS1_k127_1955931_3	158189.SpiBuddy_0494	5.999e-55	201.0	COG1309@1|root,COG1309@2|Bacteria,2JB6R@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1955931_0	293826.Amet_3747	2.812e-230	721.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36DRC@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS1_k127_1955931_2	293826.Amet_3748	6.048e-144	463.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS1_k127_1955931_6	293826.Amet_3749	2.829e-27	113.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36EI7@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS1_k127_1957618_2	357808.RoseRS_3186	7.68e-11	73.0	2ECS5@1|root,336PT@2|Bacteria,2G96H@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
MMS1_k127_1957618_0	1216932.CM240_2620	7.658e-27	112.0	COG4627@1|root,COG4627@2|Bacteria,1VACW@1239|Firmicutes,24NCH@186801|Clostridia,36NEC@31979|Clostridiaceae	186801|Clostridia	S	Stress responsive A B barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
MMS1_k127_1957618_1	1410668.JNKC01000001_gene1766	3.431e-24	104.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24CFW@186801|Clostridia,36VPS@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS1_k127_1962392_1	869209.Tresu_2121	2.259e-72	250.0	COG1136@1|root,COG1136@2|Bacteria,2J6WT@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
MMS1_k127_1962392_0	573413.Spirs_1923	7.955e-92	317.0	COG4591@1|root,COG4591@2|Bacteria,2J5D9@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
MMS1_k127_1962584_0	744872.Spica_2453	2.046e-131	425.0	COG4209@1|root,COG4209@2|Bacteria,2J7PR@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_1962584_1	744872.Spica_2452	3.13e-117	383.0	COG0395@1|root,COG0395@2|Bacteria,2J6GQ@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_1962584_2	931276.Cspa_c16530	4.684e-44	163.0	COG2755@1|root,COG2755@2|Bacteria,1V2SC@1239|Firmicutes,24H62@186801|Clostridia,36JBP@31979|Clostridiaceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
MMS1_k127_1964205_0	177439.DP1976	1.857e-154	500.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MMZW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the DEAD box helicase family	dbpA	-	3.6.4.13	ko:K05591	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DEAD,DbpA,Helicase_C
MMS1_k127_1964205_1	573413.Spirs_3388	7.032e-90	304.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_1964205_4	525367.HMPREF0556_10232	7.9e-14	81.0	COG1309@1|root,COG1309@2|Bacteria,1VM8R@1239|Firmicutes,4HRXE@91061|Bacilli	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_1964205_3	1227352.C173_20591	1.095e-32	139.0	COG4977@1|root,COG4977@2|Bacteria,1UJPF@1239|Firmicutes	1239|Firmicutes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_1964205_2	756499.Desde_1483	9.022e-50	183.0	COG1670@1|root,COG1670@2|Bacteria,1VDNG@1239|Firmicutes,24HSI@186801|Clostridia	186801|Clostridia	J	Acetyltransferases including N-acetylases of ribosomal proteins	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
MMS1_k127_1967203_3	598659.NAMH_0408	2.135e-17	83.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,42S7E@68525|delta/epsilon subdivisions,2YP7T@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	Q	2-keto-4-pentenoate hydratase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
MMS1_k127_1967203_2	1307761.L21SP2_2524	4.027e-105	355.0	COG1609@1|root,COG1609@2|Bacteria,2J8A6@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K02103	-	-	-	-	ko00000,ko03000	-	-	-	GntR,Peripla_BP_3
MMS1_k127_1967203_1	926560.KE387023_gene1910	1.538e-166	538.0	COG3507@1|root,COG3507@2|Bacteria,1WM4Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Glycosyl hydrolases family 43	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
MMS1_k127_1967203_0	1480694.DC28_13715	2.071e-183	584.0	COG1653@1|root,COG1653@2|Bacteria,2J84C@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding protein, family 1	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1
MMS1_k127_1967203_4	1480694.DC28_13720	1.528e-07	55.0	COG1175@1|root,COG1175@2|Bacteria,2J82P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_1969225_0	1307761.L21SP2_0225	2.639e-92	308.0	COG0205@1|root,COG0205@2|Bacteria,2J6KH@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
MMS1_k127_1969225_1	1123274.KB899432_gene2943	3.993e-50	188.0	COG0598@1|root,COG0598@2|Bacteria,2J6SS@203691|Spirochaetes	203691|Spirochaetes	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMS1_k127_1972920_2	1123274.KB899430_gene1690	5.429e-21	93.0	COG0828@1|root,COG0828@2|Bacteria,2J8QT@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
MMS1_k127_1972920_1	545694.TREPR_0999	7.346e-58	213.0	COG0739@1|root,COG0739@2|Bacteria,2J7J7@203691|Spirochaetes	203691|Spirochaetes	M	M23 M37 peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS1_k127_1972920_0	573413.Spirs_2141	1.731e-107	359.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
MMS1_k127_1979786_5	443143.GM18_0333	0.0003874	48.0	COG0457@1|root,COG0457@2|Bacteria	443143.GM18_0333|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1979786_1	1123274.KB899421_gene1805	1.417e-183	580.0	COG1077@1|root,COG1077@2|Bacteria,2J59M@203691|Spirochaetes	203691|Spirochaetes	D	cell shape determining protein, MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
MMS1_k127_1979786_3	744872.Spica_1388	1.33e-64	231.0	COG1792@1|root,COG1792@2|Bacteria,2J77U@203691|Spirochaetes	203691|Spirochaetes	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
MMS1_k127_1979786_4	1125725.HMPREF1325_0409	1.485e-16	86.0	COG2891@1|root,COG2891@2|Bacteria,2J89Q@203691|Spirochaetes	203691|Spirochaetes	M	Rod shape-determining protein (MreD)	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
MMS1_k127_1979786_0	1123274.KB899421_gene1802	6.011e-214	682.0	COG0768@1|root,COG0768@2|Bacteria,2J595@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
MMS1_k127_1979786_2	744872.Spica_1385	6.092e-119	396.0	COG0772@1|root,COG0772@2|Bacteria,2J62H@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the SEDS family. MrdB RodA subfamily	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
MMS1_k127_1980373_0	632335.Calkr_2234	1.071e-120	406.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
MMS1_k127_1980411_2	1480694.DC28_13275	5.289e-18	86.0	arCOG15062@1|root,32Y8D@2|Bacteria,2J908@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PQ-loop
MMS1_k127_1980411_1	1121481.AUAS01000008_gene2948	1.863e-21	105.0	COG1983@1|root,COG1983@2|Bacteria,4NR1R@976|Bacteroidetes,47QQE@768503|Cytophagia	976|Bacteroidetes	KT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
MMS1_k127_1980411_3	1123277.KB893187_gene2725	9.236e-09	65.0	COG1983@1|root,COG1983@2|Bacteria,4NS0M@976|Bacteroidetes,47QMV@768503|Cytophagia	976|Bacteroidetes	KT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
MMS1_k127_1980411_0	1307761.L21SP2_2920	3.328e-107	357.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
MMS1_k127_1983683_2	269799.Gmet_2750	2.679e-06	51.0	COG0407@1|root,COG0407@2|Bacteria,1R8VY@1224|Proteobacteria,42QM1@68525|delta/epsilon subdivisions,2WMMS@28221|Deltaproteobacteria,43VCU@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
MMS1_k127_1983683_1	269799.Gmet_2749	1.608e-40	157.0	2BWMW@1|root,32QZS@2|Bacteria,1N0VJ@1224|Proteobacteria,42TTU@68525|delta/epsilon subdivisions,2WQ5I@28221|Deltaproteobacteria,43VX0@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
MMS1_k127_1983683_0	1265505.ATUG01000003_gene743	8.454e-94	327.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42YTN@68525|delta/epsilon subdivisions,2WUPY@28221|Deltaproteobacteria,2MMZM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
MMS1_k127_1986879_3	390989.JOEG01000008_gene1466	0.0009651	49.0	COG4402@1|root,COG4402@2|Bacteria,2I90K@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
MMS1_k127_1986879_1	889378.Spiaf_1006	9.519e-29	115.0	COG3344@1|root,COG3344@2|Bacteria,2J9NB@203691|Spirochaetes	203691|Spirochaetes	H	Group II intron, maturase-specific	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
MMS1_k127_1986879_0	1121396.KB893104_gene1793	6.862e-40	150.0	COG2944@1|root,COG2944@2|Bacteria,1PT1V@1224|Proteobacteria,43EF1@68525|delta/epsilon subdivisions,2X9EA@28221|Deltaproteobacteria,2MP5W@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS1_k127_1986879_2	1121396.KB893104_gene1792	8.191e-21	94.0	COG4737@1|root,COG4737@2|Bacteria,1NAIM@1224|Proteobacteria,42WQ7@68525|delta/epsilon subdivisions,2WS7M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	RelE toxin of RelE / RelB toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	RelE
MMS1_k127_1987288_1	889378.Spiaf_2077	1.312e-17	88.0	COG0443@1|root,COG0443@2|Bacteria	2|Bacteria	O	unfolded protein binding	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70,Peptidase_C14,Pkinase
MMS1_k127_1987288_2	395961.Cyan7425_1520	1.643e-08	65.0	COG0484@1|root,COG0484@2|Bacteria,1G5UK@1117|Cyanobacteria	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_2
MMS1_k127_1987288_0	273068.TTE1417	1.227e-32	142.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,42END@68295|Thermoanaerobacterales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
MMS1_k127_1987913_0	338969.Rfer_2016	7.672e-157	532.0	COG3452@1|root,COG5001@1|root,COG3452@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GAF_2,GGDEF,PAS_4,PAS_8,PAS_9
MMS1_k127_1987913_1	639282.DEFDS_P182	8.095e-06	54.0	COG0835@1|root,COG0835@2|Bacteria,2GF44@200930|Deferribacteres	200930|Deferribacteres	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_1993766_1	665571.STHERM_c10350	9.406e-80	273.0	COG0157@1|root,COG0157@2|Bacteria,2J93N@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767,ko:K03813	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
MMS1_k127_1993766_0	1307761.L21SP2_1446	3.559e-186	595.0	COG0029@1|root,COG0029@2|Bacteria,2JBD7@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS1_k127_1993766_2	545695.TREAZ_3501	1.793e-49	188.0	COG1947@1|root,COG1947@2|Bacteria,2J7N4@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS1_k127_1993766_4	1480694.DC28_01185	3.962e-37	141.0	COG2088@1|root,COG2088@2|Bacteria,2J7XR@203691|Spirochaetes	203691|Spirochaetes	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
MMS1_k127_1993766_3	1480694.DC28_01175	3.31e-49	182.0	COG1825@1|root,COG1825@2|Bacteria,2J75H@203691|Spirochaetes	203691|Spirochaetes	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
MMS1_k127_1993766_5	1321784.HMPREF1987_02052	1.217e-10	63.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,25RBW@186804|Peptostreptococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
MMS1_k127_1993949_0	748224.HMPREF9436_00908	1.498e-179	568.0	COG0562@1|root,COG0562@2|Bacteria,1TQB9@1239|Firmicutes,249BR@186801|Clostridia,3WHCZ@541000|Ruminococcaceae	186801|Clostridia	M	UDP-galactopyranose mutase	glf	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
MMS1_k127_1993949_1	335541.Swol_2476	9.489e-155	496.0	COG1840@1|root,COG1840@2|Bacteria,1UYVQ@1239|Firmicutes,25C4Y@186801|Clostridia	186801|Clostridia	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
MMS1_k127_1993949_2	335541.Swol_2477	3.942e-137	451.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia,42KTQ@68298|Syntrophomonadaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
MMS1_k127_1994848_5	641491.DND132_3038	6.197e-06	57.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,439Y8@68525|delta/epsilon subdivisions,2X058@28221|Deltaproteobacteria,2MAKN@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_1994848_3	1283300.ATXB01000001_gene1382	2.992e-60	213.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1XF3U@135618|Methylococcales	135618|Methylococcales	S	PFAM Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
MMS1_k127_1994848_4	641107.CDLVIII_2131	1.959e-15	78.0	2DMP1@1|root,32SS8@2|Bacteria,1VFZZ@1239|Firmicutes,24G0S@186801|Clostridia,36I58@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3237)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
MMS1_k127_1994848_0	1307761.L21SP2_1484	2.437e-181	581.0	COG3639@1|root,COG3639@2|Bacteria,2J6TW@203691|Spirochaetes	203691|Spirochaetes	U	ABC transporter (Permease)	-	-	-	ko:K02042	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	BPD_transp_1
MMS1_k127_1994848_1	1307761.L21SP2_1483	5.757e-119	387.0	COG3638@1|root,COG3638@2|Bacteria,2J6UW@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system	phnC	-	3.6.3.28	ko:K02041	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.9	-	-	ABC_tran
MMS1_k127_1994848_2	1307761.L21SP2_1482	4.683e-117	383.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
MMS1_k127_1996172_2	1265505.ATUG01000001_gene4040	1.563e-138	464.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2MIVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_2
MMS1_k127_1996172_1	1408422.JHYF01000006_gene1227	8.391e-156	503.0	COG2235@1|root,COG2235@2|Bacteria,1TQWS@1239|Firmicutes,249V9@186801|Clostridia,36DPX@31979|Clostridiaceae	186801|Clostridia	E	Arginine dihydrolase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
MMS1_k127_1996172_0	1307761.L21SP2_1013	1.129e-173	548.0	COG0078@1|root,COG0078@2|Bacteria,2J5RT@203691|Spirochaetes	203691|Spirochaetes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS1_k127_1996405_1	573413.Spirs_1536	7.344e-56	199.0	2E1YA@1|root,32X70@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1996405_0	1123274.KB899413_gene882	3.566e-151	497.0	COG0497@1|root,COG0497@2|Bacteria,2J5E5@203691|Spirochaetes	203691|Spirochaetes	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
MMS1_k127_1996405_2	889378.Spiaf_2131	5.321e-35	136.0	COG0061@1|root,COG0061@2|Bacteria,2J5BE@203691|Spirochaetes	203691|Spirochaetes	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMS1_k127_1997947_1	1292035.H476_2085	3.664e-19	89.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,25SWH@186804|Peptostreptococcaceae	186801|Clostridia	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
MMS1_k127_1997947_0	111781.Lepto7376_0505	7.379e-185	590.0	COG2304@1|root,COG2304@2|Bacteria,1G3PE@1117|Cyanobacteria,1H7T7@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF3520)	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
MMS1_k127_1999315_7	1499683.CCFF01000012_gene1261	1.284e-27	117.0	COG3250@1|root,COG3250@2|Bacteria,1TSMY@1239|Firmicutes,24B54@186801|Clostridia,36H96@31979|Clostridiaceae	186801|Clostridia	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
MMS1_k127_1999315_1	247633.GP2143_14556	2.524e-189	608.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3,PA14
MMS1_k127_1999315_0	596324.TREVI0001_2172	1.119e-195	619.0	COG2211@1|root,COG2211@2|Bacteria,2J5SZ@203691|Spirochaetes	203691|Spirochaetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1999315_5	649747.HMPREF0083_04527	1.534e-37	153.0	COG0583@1|root,COG0583@2|Bacteria,1TSDV@1239|Firmicutes,4HCM6@91061|Bacilli,26RU2@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	lysR2	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_1999315_6	598467.BrE312_0272	1.071e-27	121.0	COG0730@1|root,COG0730@2|Bacteria,1RAG9@1224|Proteobacteria,1S2RX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
MMS1_k127_1999315_3	717231.Flexsi_1886	1.257e-103	346.0	COG0604@1|root,COG0604@2|Bacteria,2GEK3@200930|Deferribacteres	200930|Deferribacteres	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_1999315_2	1121396.KB893072_gene1224	5.816e-133	427.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,42N2E@68525|delta/epsilon subdivisions,2WJFV@28221|Deltaproteobacteria,2MIP6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24,DUF4339
MMS1_k127_1999315_4	583355.Caka_1597	3.63e-70	254.0	COG0668@1|root,COG0668@2|Bacteria,46UFI@74201|Verrucomicrobia,3K8BZ@414999|Opitutae	414999|Opitutae	M	mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMS1_k127_2001985_8	221288.JH992901_gene4177	3.315e-09	59.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2001985_4	485913.Krac_7418	9.925e-80	270.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
MMS1_k127_2001985_0	1042156.CXIVA_07000	9.898e-217	692.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36FQY@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer2_4,Fer4_20,Fer4_7,NADH-G_4Fe-4S_3,Pyr_redox_2
MMS1_k127_2001985_5	1304865.JAGF01000001_gene2244	1.06e-45	172.0	COG1145@1|root,COG1894@1|root,COG1145@2|Bacteria,COG1894@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	napG	-	1.4.1.13,1.4.1.14,1.6.5.3	ko:K00265,ko:K00335,ko:K02573	ko00190,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00190,map00250,map00910,map01100,map01110,map01120,map01130,map01230	M00144	R00093,R00114,R00248,R11945	RC00006,RC00010,RC00061,RC02799	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_16,Fer4_4,Fer4_7,Glu_synthase,NADH_4Fe-4S
MMS1_k127_2001985_3	1256908.HMPREF0373_03456	2.555e-114	383.0	COG2271@1|root,COG2271@2|Bacteria,1VR8X@1239|Firmicutes	1239|Firmicutes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2001985_1	1304865.JAGF01000001_gene2243	1.62e-202	642.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
MMS1_k127_2001985_2	742738.HMPREF9460_02585	1.265e-127	431.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,2682T@186813|unclassified Clostridiales	186801|Clostridia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
MMS1_k127_2001985_6	1123075.AUDP01000025_gene379	1.226e-43	179.0	COG2972@1|root,COG2972@2|Bacteria,1U0TK@1239|Firmicutes,25KJU@186801|Clostridia,3WPTI@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
MMS1_k127_2001985_7	936596.HMPREF1495_2052	2.758e-22	101.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,1HV49@1164882|Lachnoanaerobaculum	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_20020_3	1122947.FR7_0752	5.005e-51	190.0	COG0010@1|root,COG0010@2|Bacteria,1V45X@1239|Firmicutes	1239|Firmicutes	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS1_k127_20020_1	937777.Deipe_3118	1.4e-73	272.0	COG3424@1|root,COG3424@2|Bacteria	2|Bacteria	Q	synthase	bcsA	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
MMS1_k127_20020_4	243230.DR_A0327	8.684e-27	127.0	COG2227@1|root,COG2227@2|Bacteria,1WMID@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_20020_2	96561.Dole_2097	2.552e-66	236.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS1_k127_20020_0	694431.DESACE_07255	2.121e-77	269.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2M6R4@213113|Desulfurellales	28221|Deltaproteobacteria	C	Cytochrome bd terminal oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
MMS1_k127_2009886_1	929713.NIASO_15090	1.903e-10	71.0	COG2207@1|root,COG2207@2|Bacteria,4NMFW@976|Bacteroidetes,1IWAF@117747|Sphingobacteriia	976|Bacteroidetes	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
MMS1_k127_2009886_0	1304885.AUEY01000011_gene1735	0.0	1238.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MIP0@213118|Desulfobacterales	68525|delta/epsilon subdivisions	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
MMS1_k127_2010994_0	1042156.CXIVA_24790	2.851e-104	342.0	28K30@1|root,2Z9SA@2|Bacteria,1TQKJ@1239|Firmicutes,24DSI@186801|Clostridia,36H5U@31979|Clostridiaceae	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2010994_1	889378.Spiaf_1327	3.312e-55	215.0	2CH87@1|root,2ZAVC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2012667_3	1492738.FEM21_11630	8.728e-56	198.0	COG0363@1|root,COG0363@2|Bacteria,4PB68@976|Bacteroidetes,1ICNY@117743|Flavobacteriia,2NTX7@237|Flavobacterium	976|Bacteroidetes	G	glucosamine-6-phosphate deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2012667_1	573413.Spirs_3035	1.417e-106	349.0	COG0641@1|root,COG0641@2|Bacteria,2J5BT@203691|Spirochaetes	203691|Spirochaetes	C	COGs COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM,SEC-C,SPASM
MMS1_k127_2012667_2	573413.Spirs_3035	2.913e-86	289.0	COG0641@1|root,COG0641@2|Bacteria,2J5BT@203691|Spirochaetes	203691|Spirochaetes	C	COGs COG0641 Arylsulfatase regulator (Fe-S oxidoreductase)	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM,SEC-C,SPASM
MMS1_k127_2012667_4	518766.Rmar_0907	6.941e-40	150.0	COG1993@1|root,COG1993@2|Bacteria,4NX2K@976|Bacteroidetes	976|Bacteroidetes	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
MMS1_k127_2012667_5	744872.Spica_2476	1.618e-27	115.0	COG0239@1|root,COG0239@2|Bacteria,2J90T@203691|Spirochaetes	203691|Spirochaetes	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
MMS1_k127_2012667_0	1307761.L21SP2_3463	1.575e-163	523.0	COG0438@1|root,COG0438@2|Bacteria,2JAA1@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_2012734_1	1123274.KB899436_gene1284	2.554e-09	69.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
MMS1_k127_2015961_0	889378.Spiaf_2722	2.063e-154	498.0	COG1875@1|root,COG1875@2|Bacteria,2J769@203691|Spirochaetes	203691|Spirochaetes	T	PIN domain	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
MMS1_k127_2015961_1	288000.BBta_0986	5.011e-38	152.0	COG1073@1|root,COG1073@2|Bacteria,1MYHF@1224|Proteobacteria,2UUQV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
MMS1_k127_2015961_2	62928.azo2622	4.465e-16	81.0	COG2199@1|root,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,2WEF3@28216|Betaproteobacteria,2KZV3@206389|Rhodocyclales	206389|Rhodocyclales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_2019508_2	1410625.JHWK01000002_gene593	1.684e-57	205.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,27IMY@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Phosphoglucose isomerase	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
MMS1_k127_2019508_5	1232437.KL662006_gene4430	7.257e-27	120.0	COG0619@1|root,COG0619@2|Bacteria,1Q039@1224|Proteobacteria,42RI8@68525|delta/epsilon subdivisions,2WNSV@28221|Deltaproteobacteria,2MK1S@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Cobalt transport protein	-	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
MMS1_k127_2019508_0	1089553.Tph_c21020	2.45e-86	292.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,42F22@68295|Thermoanaerobacterales	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16784,ko:K16786	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
MMS1_k127_2019508_3	177437.HRM2_26930	1.431e-48	179.0	COG1268@1|root,COG1268@2|Bacteria,1RH78@1224|Proteobacteria,42RTB@68525|delta/epsilon subdivisions,2WNS7@28221|Deltaproteobacteria,2MK04@213118|Desulfobacterales	28221|Deltaproteobacteria	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
MMS1_k127_2019508_1	1232437.KL662006_gene4433	4.816e-60	219.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2MIAS@213118|Desulfobacterales	28221|Deltaproteobacteria	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
MMS1_k127_2019508_4	1094980.Mpsy_1159	6.285e-40	164.0	COG4809@1|root,arCOG03369@2157|Archaea,2Y2IY@28890|Euryarchaeota,2NAH3@224756|Methanomicrobia	224756|Methanomicrobia	G	ADP-specific Phosphofructokinase/Glucokinase conserved region	-	-	2.7.1.146,2.7.1.147	ko:K00918	ko00010,ko00030,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00680,map01100,map01110,map01120,map01130,map01200	M00001	R05805,R09084,R09085,R09086	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ADP_PFK_GK
MMS1_k127_2021178_0	935948.KE386495_gene1905	8.655e-250	788.0	COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,42FH7@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Glycoside hydrolase, clan GH-D	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
MMS1_k127_2021178_1	1540257.JQMW01000013_gene1059	1.051e-74	263.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,24D5Y@186801|Clostridia,36E83@31979|Clostridiaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_2021178_3	1095750.HMPREF9970_1577	2.047e-49	194.0	COG1653@1|root,COG1653@2|Bacteria,1TS2P@1239|Firmicutes,24EIW@186801|Clostridia,1HW8H@1164882|Lachnoanaerobaculum	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_2021178_2	216816.GS08_00685	4.414e-71	252.0	COG1175@1|root,COG1175@2|Bacteria,2GKJI@201174|Actinobacteria,4D0JI@85004|Bifidobacteriales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_2022633_1	744872.Spica_1166	4.83e-22	103.0	COG1315@1|root,COG1315@2|Bacteria,2J6E5@203691|Spirochaetes	203691|Spirochaetes	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
MMS1_k127_2022633_2	1280390.CBQR020000063_gene1309	1.32e-05	56.0	COG2197@1|root,COG2197@2|Bacteria,1V2GV@1239|Firmicutes,4HGV4@91061|Bacilli,26XHG@186822|Paenibacillaceae	91061|Bacilli	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GerE,PocR
MMS1_k127_2022633_0	906968.Trebr_2506	1.252e-26	115.0	28R06@1|root,2ZDEW@2|Bacteria,2JASI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2029520_5	665571.STHERM_c20950	1.371e-31	137.0	COG0840@1|root,COG0840@2|Bacteria,2J7RU@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_2029520_4	768704.Desmer_3136	1.034e-63	233.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,24ANY@186801|Clostridia,26317@186807|Peptococcaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_2029520_1	1461579.CCNK01000039_gene1844	9.256e-122	395.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,1RRUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	quinone reductase	cdhC	-	-	-	-	-	-	-	-	-	-	-	BKACE
MMS1_k127_2029520_0	598467.BrE312_2857	9.728e-142	460.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_2029520_2	332101.JIBU02000001_gene4331	4.029e-96	323.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,36G1A@31979|Clostridiaceae	186801|Clostridia	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
MMS1_k127_2029520_3	457421.CBFG_01311	6.958e-64	225.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,26A52@186813|unclassified Clostridiales	186801|Clostridia	C	Acetokinase family	-	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
MMS1_k127_2031533_0	1123400.KB904772_gene3332	1.169e-24	116.0	COG0500@1|root,COG0500@2|Bacteria,1MVFJ@1224|Proteobacteria,1RY0W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2033664_0	1123274.KB899418_gene2295	2.917e-78	275.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
MMS1_k127_2033963_3	621372.ACIH01000217_gene1072	1.227e-42	170.0	COG2972@1|root,COG2972@2|Bacteria,1TQZM@1239|Firmicutes,4I6FM@91061|Bacilli,26STD@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
MMS1_k127_2033963_0	621372.ACIH01000217_gene1073	1.191e-167	537.0	COG1653@1|root,COG1653@2|Bacteria,1TQ6X@1239|Firmicutes,4HD0Z@91061|Bacilli,274JY@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_2033963_2	1122918.KB907267_gene59	1.233e-130	423.0	COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,4HFEK@91061|Bacilli,26QVA@186822|Paenibacillaceae	91061|Bacilli	G	COG1175 ABC-type sugar transport systems, permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2033963_1	1274374.CBLK010000079_gene3981	1.869e-131	427.0	COG0395@1|root,COG0395@2|Bacteria,1TPIF@1239|Firmicutes,4HBYY@91061|Bacilli,274ND@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter ATP-binding protein	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2033963_4	1028801.RG1141_PA13860	6.463e-09	58.0	COG4225@1|root,COG4225@2|Bacteria,1NQTS@1224|Proteobacteria,2U2ZS@28211|Alphaproteobacteria,4BBAC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
MMS1_k127_2035482_1	946483.Cenrod_1629	1.799e-20	94.0	COG1653@1|root,COG1653@2|Bacteria,1N98V@1224|Proteobacteria,2VTEQ@28216|Betaproteobacteria,4AG2I@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K10117	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	SBP_bac_1
MMS1_k127_2035482_0	1123274.KB899410_gene3573	1.5e-110	393.0	COG0457@1|root,COG0457@2|Bacteria,2J5XG@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
MMS1_k127_2035671_5	1121904.ARBP01000010_gene2323	0.0002429	52.0	COG0457@1|root,COG1462@1|root,COG0457@2|Bacteria,COG1462@2|Bacteria	2|Bacteria	M	curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
MMS1_k127_2035671_1	748247.AZKH_4153	9.976e-142	462.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVW1@206389|Rhodocyclales	206389|Rhodocyclales	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
MMS1_k127_2035671_3	1195236.CTER_0200	2.248e-44	163.0	COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia	186801|Clostridia	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
MMS1_k127_2035671_0	644282.Deba_1148	5.992e-158	509.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS1_k127_2035671_2	1313304.CALK_2313	4.064e-134	437.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	ldhA	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_2035671_4	1216932.CM240_3303	1.9e-09	67.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia,36GZE@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_2037002_10	316067.Geob_2332	1.041e-36	152.0	COG4191@1|root,COG4564@1|root,COG4191@2|Bacteria,COG4564@2|Bacteria,1R5Q1@1224|Proteobacteria,42RPW@68525|delta/epsilon subdivisions,2WK10@28221|Deltaproteobacteria,43UCM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Cache domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_2
MMS1_k127_2037002_5	1280668.ATVT01000005_gene1910	6.644e-96	327.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,4BX2Y@830|Butyrivibrio	186801|Clostridia	E	Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_2037002_8	1123274.KB899425_gene2764	1.436e-66	233.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	vsrD	-	-	ko:K02282,ko:K07689	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	GerE,Response_reg
MMS1_k127_2037002_1	1123274.KB899425_gene2763	9.168e-246	793.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,2J5JI@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Reg_prop,Y_Y_Y
MMS1_k127_2037002_3	1123274.KB899425_gene2769	6.612e-152	488.0	COG3181@1|root,COG3181@2|Bacteria,2J7TJ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
MMS1_k127_2037002_9	1499967.BAYZ01000050_gene2800	6.686e-39	152.0	2E96H@1|root,333F3@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
MMS1_k127_2037002_0	1123274.KB899425_gene2771	1.712e-252	786.0	COG3333@1|root,COG3333@2|Bacteria,2J70X@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
MMS1_k127_2037002_6	1499967.BAYZ01000050_gene2805	1.403e-93	320.0	COG3053@1|root,COG3053@2|Bacteria,2NQHQ@2323|unclassified Bacteria	2|Bacteria	H	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase	citC	-	6.2.1.22	ko:K01910	ko02020,map02020	-	R04449	RC00012,RC00039	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Citrate_ly_lig
MMS1_k127_2037002_11	1123274.KB899425_gene2766	5.737e-30	121.0	COG3052@1|root,COG3052@2|Bacteria,2J91N@203691|Spirochaetes	203691|Spirochaetes	C	Covalent carrier of the coenzyme of citrate lyase	citD	-	-	ko:K01646	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001	-	-	-	ACP
MMS1_k127_2037002_4	748727.CLJU_c30480	5.094e-131	427.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,36E49@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS12480	HpcH_HpaI,Malate_synthase
MMS1_k127_2037002_2	1123274.KB899425_gene2768	2.184e-245	766.0	COG3051@1|root,COG3051@2|Bacteria,2J5CP@203691|Spirochaetes	203691|Spirochaetes	H	Citrate (pro-3S)-lyase alpha chain	citF	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
MMS1_k127_2037002_7	941824.TCEL_00887	2.354e-70	247.0	COG1767@1|root,COG1767@2|Bacteria,1TQGQ@1239|Firmicutes,24BQH@186801|Clostridia,36GCU@31979|Clostridiaceae	186801|Clostridia	H	ATP:dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG,CitX
MMS1_k127_2038789_1	1122927.KB895415_gene4390	7.698e-36	141.0	COG1051@1|root,COG3981@1|root,COG1051@2|Bacteria,COG3981@2|Bacteria,1V1C4@1239|Firmicutes,4HG6C@91061|Bacilli,26XIE@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
MMS1_k127_2038789_2	1410625.JHWK01000002_gene134	2.549e-16	83.0	COG3153@1|root,COG3153@2|Bacteria,1VZZ4@1239|Firmicutes,24RJR@186801|Clostridia	186801|Clostridia	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2038789_0	635013.TherJR_1300	1.346e-183	599.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,260CF@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
MMS1_k127_2040031_1	452637.Oter_2681	2.883e-53	192.0	COG0066@1|root,COG0066@2|Bacteria,46U20@74201|Verrucomicrobia,3K7RN@414999|Opitutae	414999|Opitutae	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMS1_k127_2040031_0	583355.Caka_2810	5.982e-223	698.0	COG0065@1|root,COG0065@2|Bacteria,46SUM@74201|Verrucomicrobia,3K7KT@414999|Opitutae	414999|Opitutae	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
MMS1_k127_2040031_2	1295642.H839_16918	2.129e-25	109.0	COG1846@1|root,COG1846@2|Bacteria,1VA2C@1239|Firmicutes,4HMFU@91061|Bacilli	91061|Bacilli	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR,MarR_2
MMS1_k127_2046273_3	573413.Spirs_1916	4.51e-45	181.0	COG1729@1|root,COG1729@2|Bacteria,2J6ZY@203691|Spirochaetes	203691|Spirochaetes	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2046273_2	573413.Spirs_2763	4.908e-51	193.0	COG0791@1|root,COG4642@1|root,COG0791@2|Bacteria,COG4642@2|Bacteria,2J68J@203691|Spirochaetes	203691|Spirochaetes	M	NlpC P60 family	-	-	-	ko:K13695,ko:K19303	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
MMS1_k127_2046273_0	573413.Spirs_1915	2.631e-174	568.0	COG1449@1|root,COG1449@2|Bacteria,2J5C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
MMS1_k127_2046273_1	1123274.KB899415_gene2523	8.043e-92	309.0	COG2878@1|root,COG2878@2|Bacteria,2J5VT@203691|Spirochaetes	203691|Spirochaetes	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_9
MMS1_k127_2046273_4	1123274.KB899415_gene2522	1.584e-42	158.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
MMS1_k127_2050324_0	1235792.C808_03549	7.464e-131	439.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,24ECR@186801|Clostridia	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_2050994_0	1286631.X805_39240	2.188e-122	400.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2VHRA@28216|Betaproteobacteria,1KKB9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_2050994_1	1041138.KB890221_gene1040	1.407e-94	319.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria,4BARC@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K02057,ko:K10440,ko:K17206,ko:K17214	ko02010,map02010	M00212,M00221,M00591,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.15,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_2052064_0	1123274.KB899436_gene1284	4.153e-183	617.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
MMS1_k127_2056553_1	1056512.D515_04289	5.163e-109	366.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,1XT2Z@135623|Vibrionales	135623|Vibrionales	E	COG1448 Aspartate tyrosine aromatic aminotransferase	-	-	2.6.1.1	ko:K00813	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_2056553_2	1123228.AUIH01000003_gene908	9.928e-63	228.0	COG0697@1|root,COG0697@2|Bacteria,1RI87@1224|Proteobacteria,1S4HT@1236|Gammaproteobacteria,1XJNZ@135619|Oceanospirillales	135619|Oceanospirillales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2056553_3	1123228.AUIH01000003_gene907	1.742e-48	178.0	COG1522@1|root,COG1522@2|Bacteria,1RISV@1224|Proteobacteria,1S78M@1236|Gammaproteobacteria,1XRE8@135619|Oceanospirillales	135619|Oceanospirillales	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMS1_k127_2056553_0	1380370.JIBA01000011_gene3209	1.408e-150	484.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,4FJWJ@85021|Intrasporangiaceae	201174|Actinobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.156,4.2.1.42	ko:K20023	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS1_k127_2056553_4	999411.HMPREF1092_00683	1.134e-27	122.0	COG0583@1|root,COG0583@2|Bacteria,1V1ND@1239|Firmicutes,25C6Z@186801|Clostridia,36WQK@31979|Clostridiaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2057714_4	760011.Spico_1662	4.164e-15	80.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,2J7G6@203691|Spirochaetes	203691|Spirochaetes	K	SMART Helix-turn-helix, AraC type, DNA binding domain	-	-	-	ko:K02854,ko:K02855	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
MMS1_k127_2057714_0	931276.Cspa_c48360	1.403e-137	446.0	COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,247RB@186801|Clostridia,36ENV@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the dehydration of D-mannonate	uxuA	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
MMS1_k127_2057714_1	479434.Sthe_2697	2.093e-79	272.0	COG1656@1|root,COG1977@1|root,COG1656@2|Bacteria,COG1977@2|Bacteria,2G6GZ@200795|Chloroflexi,27Y8I@189775|Thermomicrobia	189775|Thermomicrobia	H	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
MMS1_k127_2057714_3	1480694.DC28_11645	3.523e-44	171.0	COG1639@1|root,COG1639@2|Bacteria	2|Bacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_2057714_5	309799.DICTH_1958	0.0002779	53.0	COG0834@1|root,COG2203@1|root,COG3437@1|root,COG0834@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	2.7.13.3	ko:K02030,ko:K13040	ko02020,map02020	M00236,M00514	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022	3.A.1.3	-	-	EAL,GAF_2,GGDEF,HATPase_c,HD,HD_5,HisKA,PAS_3,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_2057714_2	926550.CLDAP_30590	1.73e-46	172.0	COG1575@1|root,COG1575@2|Bacteria,2G5ZC@200795|Chloroflexi	200795|Chloroflexi	H	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS1_k127_2058188_1	1123274.KB899409_gene535	2.577e-58	217.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_2058188_0	268407.PWYN_24095	6.871e-78	267.0	COG1476@1|root,COG1476@2|Bacteria,1VS87@1239|Firmicutes	1239|Firmicutes	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
MMS1_k127_2059501_8	640081.Dsui_0096	9.054e-08	64.0	COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2VM8I@28216|Betaproteobacteria,2KV4E@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_2059501_6	1318628.MARLIPOL_14710	2.966e-49	185.0	COG0834@1|root,COG0834@2|Bacteria,1N4DM@1224|Proteobacteria,1SYZY@1236|Gammaproteobacteria,468U7@72275|Alteromonadaceae	1236|Gammaproteobacteria	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_2059501_5	246194.CHY_1374	2.589e-65	227.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,42FEX@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
MMS1_k127_2059501_4	1123009.AUID01000006_gene1003	5.863e-78	271.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,2685W@186813|unclassified Clostridiales	186801|Clostridia	C	Fumarate hydratase (Fumerase)	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
MMS1_k127_2059501_3	744872.Spica_1191	7.864e-122	398.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	alaXM	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS1_k127_2059501_7	1111728.ATYS01000003_gene1866	2.819e-35	138.0	2CDKX@1|root,32RXZ@2|Bacteria,1RKGY@1224|Proteobacteria,1S80A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4387)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4387
MMS1_k127_2059501_1	349966.DJ58_2099	1.117e-181	579.0	COG1574@1|root,COG1574@2|Bacteria,1QDPJ@1224|Proteobacteria,1RT2W@1236|Gammaproteobacteria,41EZX@629|Yersinia	1236|Gammaproteobacteria	S	to DNA for 3-methylaspartate ammonia-lyase, glutamate mutase, complete cds of Bacteria UniRef RepID O66146_CITAM	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
MMS1_k127_2059501_0	1124991.MU9_1023	8.316e-186	590.0	COG3799@1|root,COG3799@2|Bacteria,1MW90@1224|Proteobacteria,1RRUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Methylaspartate ammonia-lyase	-	-	4.3.1.2	ko:K04835	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R03696	RC00979	ko00000,ko00001,ko00002,ko01000	-	-	-	MAAL_C,MAAL_N
MMS1_k127_2059501_2	1057002.KB905370_gene2208	9.428e-147	470.0	COG4865@1|root,COG4865@2|Bacteria,1PCBW@1224|Proteobacteria,2V8HU@28211|Alphaproteobacteria,4BIZR@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Methylaspartate mutase E chain (MutE)	-	-	-	-	-	-	-	-	-	-	-	-	Met_asp_mut_E
MMS1_k127_206346_1	443254.Marpi_0643	2.705e-66	239.0	COG0477@1|root,COG2814@2|Bacteria,2GC8X@200918|Thermotogae	200918|Thermotogae	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_206346_0	1540257.JQMW01000013_gene1253	3.611e-115	384.0	COG0477@1|root,COG2814@2|Bacteria,1TSR2@1239|Firmicutes,24803@186801|Clostridia,36E86@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_206346_2	1121459.AQXE01000005_gene1587	1.027e-41	163.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,439Y8@68525|delta/epsilon subdivisions,2X058@28221|Deltaproteobacteria,2MAKN@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_2063490_5	1211814.CAPG01000090_gene4116	1.439e-19	93.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H9SP@91061|Bacilli,1ZAPS@1386|Bacillus	91061|Bacilli	P	COG2217 Cation transport ATPase	cadA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS1_k127_2063490_2	1307761.L21SP2_0593	9.635e-46	168.0	COG0640@1|root,COG0640@2|Bacteria,2J8I1@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
MMS1_k127_2063490_6	335541.Swol_2487	2.698e-19	94.0	2ESSZ@1|root,33KBC@2|Bacteria,1VPF4@1239|Firmicutes,2531D@186801|Clostridia	186801|Clostridia	S	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
MMS1_k127_2063490_0	1232437.KL662010_gene1643	4.769e-116	382.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N5U@68525|delta/epsilon subdivisions,2WKV2@28221|Deltaproteobacteria,2MJK4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	FecCD transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
MMS1_k127_2063490_1	871968.DESME_04035	8.854e-74	257.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,264S1@186807|Peptococcaceae	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
MMS1_k127_2063490_3	871968.DESME_04040	1.047e-38	153.0	COG0614@1|root,COG0614@2|Bacteria,1TQ11@1239|Firmicutes,2482R@186801|Clostridia	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS1_k127_2065893_2	665571.STHERM_c13140	3.664e-11	64.0	COG0305@1|root,COG0305@2|Bacteria,2J590@203691|Spirochaetes	203691|Spirochaetes	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
MMS1_k127_2065893_0	1123274.KB899412_gene1513	1.533e-19	91.0	2AMU2@1|root,31CQK@2|Bacteria,2J8GC@203691|Spirochaetes	203691|Spirochaetes	S	Late competence development protein ComFB	-	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
MMS1_k127_2068023_0	572479.Hprae_1356	2.543e-114	383.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia	186801|Clostridia	V	Mate efflux family protein	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_2068023_1	573413.Spirs_3795	2.824e-30	128.0	COG4254@1|root,COG4254@2|Bacteria,2J6X7@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
MMS1_k127_2068023_2	1480694.DC28_13380	2.478e-18	98.0	28UTT@1|root,2ZGXY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2068414_1	1125725.HMPREF1325_1788	1.329e-14	83.0	COG2604@1|root,COG2604@2|Bacteria,2J5F2@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
MMS1_k127_2068414_0	744872.Spica_0806	1.001e-248	775.0	COG0481@1|root,COG0481@2|Bacteria,2J5V8@203691|Spirochaetes	203691|Spirochaetes	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
MMS1_k127_2069549_3	760011.Spico_1658	1.899e-23	102.0	COG1129@1|root,COG1129@2|Bacteria,2J6Z7@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
MMS1_k127_2069549_0	158189.SpiBuddy_2232	1.035e-136	443.0	COG1879@1|root,COG1879@2|Bacteria,2J7XC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM rhamnose ABC transporter, rhamnose-binding	-	-	-	ko:K10559	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	Peripla_BP_4
MMS1_k127_2069549_2	97139.C824_01614	2.311e-40	158.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24CGG@186801|Clostridia,36VGI@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
MMS1_k127_2069549_1	665571.STHERM_c08300	7.979e-51	196.0	COG2972@1|root,COG2972@2|Bacteria,2J80B@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
MMS1_k127_2070906_2	146922.JOFU01000003_gene6980	2.606e-16	86.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
MMS1_k127_2070906_1	1313265.JNIE01000008_gene95	1.832e-39	166.0	COG2199@1|root,COG2770@1|root,COG2770@2|Bacteria,COG3706@2|Bacteria,2G439@200783|Aquificae	200783|Aquificae	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Lactamase_B
MMS1_k127_2070906_0	1121033.AUCF01000023_gene24	5.205e-46	175.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2TTUP@28211|Alphaproteobacteria,2JRGM@204441|Rhodospirillales	204441|Rhodospirillales	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
MMS1_k127_2072893_3	765420.OSCT_2305	5.895e-52	191.0	COG0366@1|root,COG0366@2|Bacteria,2G7QC@200795|Chloroflexi,376X0@32061|Chloroflexia	32061|Chloroflexia	G	SMART alpha amylase, catalytic sub domain	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
MMS1_k127_2072893_1	1480694.DC28_12370	9.457e-72	254.0	COG1609@1|root,COG1609@2|Bacteria,2J63Y@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_2072893_2	573413.Spirs_2325	2.033e-63	224.0	COG0637@1|root,COG0637@2|Bacteria,2J814@203691|Spirochaetes	203691|Spirochaetes	F	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	HAD_2,dCMP_cyt_deam_1
MMS1_k127_2072893_0	933262.AXAM01000099_gene209	1.893e-75	283.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	3.2.1.1,3.2.1.20	ko:K01176,ko:K01187	ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973	-	R00028,R00801,R00802,R02108,R02112,R06087,R06088,R11262	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH13,GH31	-	Alpha-amylase,Alpha-amylase_N
MMS1_k127_2072893_4	517417.Cpar_2020	5.319e-36	140.0	COG0370@1|root,COG0370@2|Bacteria,1FDFB@1090|Chlorobi	1090|Chlorobi	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
MMS1_k127_2073438_1	573413.Spirs_2939	1.906e-124	407.0	COG0709@1|root,COG0709@2|Bacteria,2J6VU@203691|Spirochaetes	203691|Spirochaetes	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
MMS1_k127_2073438_3	697303.Thewi_2712	7.558e-95	325.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,42F7T@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM aminotransferase class V	csd2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMS1_k127_2073438_0	1114922.CIFAM_10_02800	3.12e-139	462.0	COG1975@1|root,COG3608@1|root,COG1975@2|Bacteria,COG3608@2|Bacteria,1MWFN@1224|Proteobacteria,1T1CW@1236|Gammaproteobacteria,3WX64@544|Citrobacter	1236|Gammaproteobacteria	O	XdhC and CoxI family	yqeB	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
MMS1_k127_2073438_2	1121918.ARWE01000001_gene2110	6.778e-95	318.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria,43S5K@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
MMS1_k127_2073438_4	926692.AZYG01000091_gene1747	1.352e-61	219.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,3WBPE@53433|Halanaerobiales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
MMS1_k127_2073438_5	1499967.BAYZ01000161_gene394	4.14e-42	167.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	gtsA	-	3.6.3.30,3.6.3.55	ko:K02010,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112	ko02010,map02010	M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran,TOBE_2
MMS1_k127_2073438_6	702450.CUW_0975	4e-17	84.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes	1239|Firmicutes	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
MMS1_k127_2073815_0	545694.TREPR_3811	3.783e-83	286.0	COG0618@1|root,COG0618@2|Bacteria,2J6GG@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
MMS1_k127_2073815_2	1123274.KB899417_gene2162	1.849e-18	90.0	29BJG@1|root,2ZG2E@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2073815_1	665571.STHERM_c05810	6.975e-65	229.0	COG0466@1|root,COG0466@2|Bacteria,2J71Y@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS1_k127_2083389_0	1232429.CBLL010000049_gene1881	6.416e-08	63.0	COG1670@1|root,COG1670@2|Bacteria,2IRHX@201174|Actinobacteria,1W9UM@1268|Micrococcaceae	201174|Actinobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,GNAT_acetyltran
MMS1_k127_2084518_2	889378.Spiaf_2668	1.591e-32	128.0	COG1925@1|root,COG1925@2|Bacteria,2J8AV@203691|Spirochaetes	203691|Spirochaetes	G	phosphocarrier protein HPr	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
MMS1_k127_2084518_0	744872.Spica_2577	1.056e-139	452.0	COG1493@1|root,COG1493@2|Bacteria,2J5JA@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
MMS1_k127_2084518_3	1123274.KB899414_gene3660	4.299e-23	102.0	COG1544@1|root,COG1544@2|Bacteria,2J9DI@203691|Spirochaetes	203691|Spirochaetes	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
MMS1_k127_2084518_1	1480694.DC28_08635	1.013e-74	257.0	COG1508@1|root,COG1508@2|Bacteria,2J5KV@203691|Spirochaetes	203691|Spirochaetes	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
MMS1_k127_2084756_0	585.DR95_2835	1.591e-111	372.0	COG4573@1|root,COG4573@2|Bacteria,1MW3Q@1224|Proteobacteria,1RQAU@1236|Gammaproteobacteria,3Z0UW@583|Proteus	1236|Gammaproteobacteria	G	Tagatose 6 phosphate kinase	kbaZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K16371	ko00052,ko01100,map00052,map01100	-	R01069	RC00438,RC00439	ko00000,ko00001	-	-	iECIAI1_1343.ECIAI1_3280	Tagatose_6_P_K
MMS1_k127_2084756_2	1123511.KB905866_gene3760	3.916e-76	267.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4H3HG@909932|Negativicutes	909932|Negativicutes	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_2084756_1	1122962.AULH01000008_gene2176	6.802e-110	373.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2TR7P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylulose kinase	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
MMS1_k127_2085288_2	293826.Amet_3749	1.928e-78	265.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36EI7@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS1_k127_2085288_1	1408422.JHYF01000011_gene3423	4.805e-226	713.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,36DQ7@31979|Clostridiaceae	186801|Clostridia	C	L-lactate permease	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
MMS1_k127_2085288_0	207559.Dde_3604	7.285e-229	732.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,42M5I@68525|delta/epsilon subdivisions,2WK8Y@28221|Deltaproteobacteria,2M91E@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
MMS1_k127_2086076_1	573413.Spirs_1247	5.044e-84	295.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_2086076_2	573413.Spirs_1248	3.284e-77	277.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	CP_0512	-	-	ko:K02003,ko:K09808	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran,FtsX,MacB_PCD
MMS1_k127_2086076_0	573413.Spirs_1249	1.345e-92	309.0	COG1136@1|root,COG1136@2|Bacteria,2J6R3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_2086076_3	537011.PREVCOP_05357	1.239e-16	93.0	COG0845@1|root,COG0845@2|Bacteria,4NDUH@976|Bacteroidetes,2FM9Q@200643|Bacteroidia	976|Bacteroidetes	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
MMS1_k127_2087769_0	573413.Spirs_2049	3.619e-53	201.0	COG0457@1|root,COG0457@2|Bacteria,2J5D0@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_2
MMS1_k127_2088400_0	647113.Metok_0336	5.88e-117	398.0	COG0651@1|root,arCOG01537@2157|Archaea,2Y85B@28890|Euryarchaeota,23RIC@183939|Methanococci	183939|Methanococci	C	PFAM NADH Ubiquinone plastoquinone	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
MMS1_k127_2088400_1	526218.Sterm_2148	8.668e-72	246.0	COG0634@1|root,COG0634@2|Bacteria,3795B@32066|Fusobacteria	32066|Fusobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
MMS1_k127_2088874_0	744872.Spica_0475	2.105e-86	288.0	COG2172@1|root,COG2172@2|Bacteria,2J5HH@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS
MMS1_k127_2088874_5	744872.Spica_1093	3.924e-11	68.0	COG1366@1|root,COG1366@2|Bacteria,2J7R1@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
MMS1_k127_2088874_2	1480694.DC28_08440	8.903e-37	149.0	COG0517@1|root,COG2208@1|root,COG0517@2|Bacteria,COG2208@2|Bacteria,2J846@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
MMS1_k127_2088874_3	1480694.DC28_08440	1.064e-36	147.0	COG0517@1|root,COG2208@1|root,COG0517@2|Bacteria,COG2208@2|Bacteria,2J846@203691|Spirochaetes	203691|Spirochaetes	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
MMS1_k127_2088874_1	1480694.DC28_14815	4.097e-69	239.0	COG0118@1|root,COG0118@2|Bacteria,2J7EY@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
MMS1_k127_2088874_4	1123274.KB899415_gene2506	5.034e-34	133.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMS1_k127_2089277_2	592026.GCWU0000282_002322	3.511e-36	145.0	COG0395@1|root,COG0395@2|Bacteria,1UYHV@1239|Firmicutes,25C4Q@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_2089277_0	610130.Closa_2388	2.602e-84	289.0	COG1175@1|root,COG1175@2|Bacteria,1TQB1@1239|Firmicutes,25C4P@186801|Clostridia,2247S@1506553|Lachnoclostridium	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_2089277_1	610130.Closa_2326	2.893e-49	192.0	COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia,223Y9@1506553|Lachnoclostridium	186801|Clostridia	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
MMS1_k127_2090125_1	177439.DP2557	1.678e-37	152.0	2EVII@1|root,33NYR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2090125_0	1089550.ATTH01000001_gene2193	3.591e-124	432.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_11,AAA_12,AAA_13,AAA_15,AAA_23,DUF3732,SMC_N
MMS1_k127_2090125_2	177439.DP2559	1.222e-28	121.0	2AJFK@1|root,31A1X@2|Bacteria,1Q4QD@1224|Proteobacteria,4326M@68525|delta/epsilon subdivisions,2WYIU@28221|Deltaproteobacteria,2MP3H@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2090324_2	545695.TREAZ_1691	1.161e-37	149.0	2F99J@1|root,341KP@2|Bacteria,2J8F2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2090324_1	696281.Desru_1437	1.568e-69	244.0	2C388@1|root,30ZIR@2|Bacteria,1V245@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2090324_0	744872.Spica_2157	1.204e-103	345.0	COG0697@1|root,COG0697@2|Bacteria,2J5WD@203691|Spirochaetes	203691|Spirochaetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2093830_3	880073.Calab_3243	7.252e-46	181.0	COG2199@1|root,COG3706@2|Bacteria,2NPCY@2323|unclassified Bacteria	2|Bacteria	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,PAS,Response_reg
MMS1_k127_2093830_0	158190.SpiGrapes_2240	9.383e-198	646.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_2093830_1	158190.SpiGrapes_2239	1.058e-63	227.0	COG2834@1|root,COG2834@2|Bacteria,2JBH0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_2093830_4	573413.Spirs_1831	3.883e-31	132.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
MMS1_k127_2094630_1	1167006.UWK_03527	4.808e-54	196.0	COG1468@1|root,COG1468@2|Bacteria,1MX2S@1224|Proteobacteria,42R51@68525|delta/epsilon subdivisions,2WMQZ@28221|Deltaproteobacteria,2MJGE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function DUF83	cas4	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
MMS1_k127_2094630_0	573413.Spirs_1074	7.071e-151	483.0	COG1518@1|root,COG1518@2|Bacteria,2J69B@203691|Spirochaetes	203691|Spirochaetes	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
MMS1_k127_2094630_2	352165.HMPREF7215_1801	2.949e-25	107.0	COG1343@1|root,COG1343@2|Bacteria,3TBB1@508458|Synergistetes	508458|Synergistetes	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas2	-	-	-	-	-	-	-	-	-	-	-	CRISPR_Cas2
MMS1_k127_2095069_8	1307761.L21SP2_3163	2.181e-10	63.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
MMS1_k127_2095069_4	290317.Cpha266_2156	6.817e-50	182.0	COG2606@1|root,COG2606@2|Bacteria,1FF1M@1090|Chlorobi	1090|Chlorobi	S	PFAM YbaK prolyl-tRNA synthetase associated region	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
MMS1_k127_2095069_6	911239.CF149_02229	3.182e-15	80.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_2095069_3	237368.SCABRO_02484	5.208e-52	201.0	COG0642@1|root,COG2205@2|Bacteria	237368.SCABRO_02484|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2095069_0	909663.KI867150_gene1288	6.824e-122	409.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria,2MQVK@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS1_k127_2095069_5	1123274.KB899407_gene217	3.09e-20	101.0	COG1333@1|root,COG1333@2|Bacteria,2JAVY@203691|Spirochaetes	203691|Spirochaetes	O	ResB-like family	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
MMS1_k127_2095069_2	545694.TREPR_3192	1.131e-82	282.0	COG0755@1|root,COG0755@2|Bacteria,2JADE@203691|Spirochaetes	203691|Spirochaetes	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
MMS1_k127_2095069_1	1250006.JHZZ01000001_gene1817	2.088e-85	292.0	COG0727@1|root,COG0727@2|Bacteria,4P0AN@976|Bacteroidetes,1IMAQ@117743|Flavobacteriia,3VVHF@52959|Polaribacter	976|Bacteroidetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
MMS1_k127_2096534_7	1123274.KB899421_gene1792	7.143e-69	244.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_2096534_5	573413.Spirs_2063	4.63e-114	377.0	COG2972@1|root,COG2972@2|Bacteria,2J59G@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
MMS1_k127_2096534_4	573413.Spirs_2064	4.674e-139	460.0	COG1129@1|root,COG1129@2|Bacteria	2|Bacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10441,ko:K17214	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_2096534_6	573413.Spirs_2065	1.553e-103	347.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_2096534_0	1123274.KB899421_gene1796	6.062e-235	735.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_2096534_2	1123274.KB899421_gene1797	1.957e-163	519.0	COG1172@1|root,COG1172@2|Bacteria,2J5G1@203691|Spirochaetes	203691|Spirochaetes	U	transport system permease	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_2096534_3	573413.Spirs_2068	2.584e-148	474.0	COG1879@1|root,COG1879@2|Bacteria,2J64F@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_2096534_9	1123274.KB899408_gene3765	1.018e-20	96.0	2A6AD@1|root,30V31@2|Bacteria,2J9E0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF2992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2992
MMS1_k127_2096534_8	702450.CUW_0751	3.815e-57	213.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
MMS1_k127_2096534_1	889378.Spiaf_0924	1.484e-176	568.0	COG1022@1|root,COG1022@2|Bacteria,2J6MK@203691|Spirochaetes	203691|Spirochaetes	I	AMP-binding enzyme	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
MMS1_k127_2104782_0	573413.Spirs_0212	3.714e-95	320.0	COG0053@1|root,COG0053@2|Bacteria,2J6IT@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMS1_k127_2104782_3	232346.JHQL01000001_gene2732	4.177e-38	147.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1XMBN@135619|Oceanospirillales	135619|Oceanospirillales	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
MMS1_k127_2104782_5	744872.Spica_0858	4.099e-21	93.0	COG4231@1|root,COG4231@2|Bacteria,2JBJT@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_2104782_1	760011.Spico_1336	5.208e-94	318.0	COG2269@1|root,COG2269@2|Bacteria,2J61T@203691|Spirochaetes	203691|Spirochaetes	J	synthetase (class II)	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
MMS1_k127_2104782_2	573413.Spirs_3666	7.059e-70	242.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
MMS1_k127_2104782_4	1123274.KB899426_gene2783	1.98e-22	100.0	COG2813@1|root,COG2813@2|Bacteria,2J7DS@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	MTS
MMS1_k127_2105047_5	573413.Spirs_0879	1.069e-55	203.0	COG0013@1|root,COG0013@2|Bacteria,2J75I@203691|Spirochaetes	203691|Spirochaetes	J	alanyl tRNA synthetase	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS1_k127_2105047_6	1307761.L21SP2_2536	6.112e-39	149.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HATPase_c,Hpt,Response_reg
MMS1_k127_2105047_3	1395513.P343_04010	5.458e-91	306.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,4H9SW@91061|Bacilli,26PIU@186821|Sporolactobacillaceae	91061|Bacilli	H	N-terminal domain of lipoyl synthase of Radical_SAM family	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMS1_k127_2105047_7	1307761.L21SP2_2614	7.345e-14	72.0	COG0320@1|root,COG0320@2|Bacteria,2J6R8@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMS1_k127_2105047_0	1151292.QEW_4289	1.243e-247	769.0	COG5276@1|root,COG5276@2|Bacteria,1UUVN@1239|Firmicutes,24CXH@186801|Clostridia	186801|Clostridia	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
MMS1_k127_2105047_1	1279009.ADICEAN_03140	4.047e-139	459.0	COG0366@1|root,COG0366@2|Bacteria,4NEXF@976|Bacteroidetes,47MR6@768503|Cytophagia	976|Bacteroidetes	G	PFAM Alpha amylase, catalytic	-	GO:0000272,GO:0000287,GO:0001871,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005575,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0016020,GO:0016052,GO:0016160,GO:0016787,GO:0016798,GO:0019867,GO:0030246,GO:0030247,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046872,GO:0071704,GO:1901575,GO:2001070	3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54	ko:K01176,ko:K01208	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R03122,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,BACON
MMS1_k127_2105047_8	1343739.PAP_00225	6.645e-12	70.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,2434U@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2105047_4	877420.ATVW01000006_gene562	5.154e-86	291.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,27ITF@186928|unclassified Lachnospiraceae	186801|Clostridia	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_2105047_2	411463.EUBVEN_02039	4.305e-114	376.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,25ZS9@186806|Eubacteriaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
MMS1_k127_2105752_4	521045.Kole_1123	1.995e-18	86.0	COG0446@1|root,COG0446@2|Bacteria,2GC6J@200918|Thermotogae	200918|Thermotogae	S	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS1_k127_2105752_3	744872.Spica_1284	2.341e-89	305.0	COG2348@1|root,COG2348@2|Bacteria,2J58H@203691|Spirochaetes	203691|Spirochaetes	V	Methicillin resistance protein	femA	-	-	-	-	-	-	-	-	-	-	-	FemAB
MMS1_k127_2105752_0	573413.Spirs_2889	0.0	1012.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2J699@203691|Spirochaetes	203691|Spirochaetes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS1_k127_2105752_1	665571.STHERM_c16310	5.621e-128	419.0	COG0330@1|root,COG0330@2|Bacteria,2J5A8@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
MMS1_k127_2105752_2	665571.STHERM_c16320	1.816e-105	352.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	203691|Spirochaetes	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
MMS1_k127_2105780_6	1121448.DGI_2996	3.361e-16	81.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,1NDC7@1224|Proteobacteria,42V4C@68525|delta/epsilon subdivisions,2WRS8@28221|Deltaproteobacteria,2M89T@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	transporter antisigma-factor antagonist STAS	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS,STAS_2
MMS1_k127_2105780_0	583355.Caka_2311	8.255e-203	640.0	COG0015@1|root,COG0015@2|Bacteria,46U88@74201|Verrucomicrobia,3K7I7@414999|Opitutae	414999|Opitutae	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMS1_k127_2105780_2	1123514.KB905899_gene1510	6.067e-57	208.0	COG0388@1|root,COG0388@2|Bacteria,1MXBR@1224|Proteobacteria,1RQ4Z@1236|Gammaproteobacteria,460HR@72273|Thiotrichales	72273|Thiotrichales	S	Carbon-nitrogen hydrolase	-	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
MMS1_k127_2105780_1	926569.ANT_25080	3.125e-121	398.0	COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_2105780_4	431943.CKL_0356	1.516e-25	108.0	COG3708@1|root,COG3708@2|Bacteria,1VFMZ@1239|Firmicutes,24RKD@186801|Clostridia,36N5Y@31979|Clostridiaceae	186801|Clostridia	K	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Cass2,Zn_ribbon_2
MMS1_k127_2105780_3	572479.Hprae_1377	5.459e-29	123.0	COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia	186801|Clostridia	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
MMS1_k127_2106445_1	1408473.JHXO01000003_gene2549	2.381e-25	113.0	29HWC@1|root,304TF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
MMS1_k127_2106445_0	1480694.DC28_06910	1.472e-31	130.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	grdR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_2106445_2	1233950.IW22_24410	1.563e-12	74.0	2AKCX@1|root,31B42@2|Bacteria,4P1TT@976|Bacteroidetes,1IHFI@117743|Flavobacteriia,3ZU5G@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2106445_3	1121459.AQXE01000008_gene885	1.125e-05	51.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M7RA@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_2106505_2	931626.Awo_c23190	1.401e-15	82.0	COG1309@1|root,COG1309@2|Bacteria,1V3YX@1239|Firmicutes,24Q7E@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_2106505_3	457424.BFAG_02246	1.077e-10	69.0	COG0477@1|root,COG2814@2|Bacteria,4NG27@976|Bacteroidetes,2FNG3@200643|Bacteroidia,4ANGP@815|Bacteroidaceae	976|Bacteroidetes	EGP	the major facilitator superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
MMS1_k127_2106505_0	1408473.JHXO01000008_gene2724	8.559e-104	351.0	COG0477@1|root,COG2814@2|Bacteria,4NG27@976|Bacteroidetes,2FNG3@200643|Bacteroidia	976|Bacteroidetes	P	major facilitator superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
MMS1_k127_2106505_1	1121123.AUAO01000001_gene926	1.586e-32	132.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,2KFMT@204458|Caulobacterales	204458|Caulobacterales	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_D23
MMS1_k127_2109180_2	1123274.KB899410_gene3575	1.945e-86	299.0	COG0836@1|root,COG0836@2|Bacteria,2J6ST@203691|Spirochaetes	203691|Spirochaetes	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
MMS1_k127_2109180_1	1294142.CINTURNW_4080	1.432e-183	591.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36EQ0@31979|Clostridiaceae	186801|Clostridia	E	peptidase M24	pepQ	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
MMS1_k127_2109180_3	1408473.JHXO01000006_gene1346	8.669e-65	234.0	COG0697@1|root,COG0697@2|Bacteria,4NH9M@976|Bacteroidetes,2FPTW@200643|Bacteroidia	976|Bacteroidetes	EG	membrane	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2109180_0	1307761.L21SP2_0801	0.0	1365.0	COG0060@1|root,COG0060@2|Bacteria,2J57V@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
MMS1_k127_2111074_1	278957.ABEA03000213_gene3791	9.443e-57	213.0	COG0524@1|root,COG0524@2|Bacteria,46TT7@74201|Verrucomicrobia,3K7V3@414999|Opitutae	414999|Opitutae	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
MMS1_k127_2111074_0	545694.TREPR_0681	9.109e-201	647.0	COG0475@1|root,COG1762@1|root,COG0475@2|Bacteria,COG1762@2|Bacteria,2J603@203691|Spirochaetes	203691|Spirochaetes	GPT	PFAM Sodium hydrogen exchanger family	napA-1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
MMS1_k127_2111074_2	1285586.H131_18932	6.688e-37	151.0	2AFC0@1|root,2ZNDE@2|Bacteria,1V3B9@1239|Firmicutes,4HG84@91061|Bacilli,3IX7K@400634|Lysinibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2113651_0	1307761.L21SP2_2149	1.738e-128	421.0	COG0738@1|root,COG0738@2|Bacteria,2J6KA@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2113651_3	93220.LV28_07535	2.024e-42	165.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,1K2MC@119060|Burkholderiaceae	28216|Betaproteobacteria	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
MMS1_k127_2113651_2	1244869.H261_09824	1.61e-53	196.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,2JR2U@204441|Rhodospirillales	204441|Rhodospirillales	P	COG4149 ABC-type molybdate transport system, permease component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
MMS1_k127_2113651_1	1265505.ATUG01000003_gene553	8.891e-56	202.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,42NN3@68525|delta/epsilon subdivisions,2WJZP@28221|Deltaproteobacteria,2MJAW@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
MMS1_k127_2113651_5	1122917.KB899682_gene3788	2.782e-07	59.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1TRV5@1239|Firmicutes,4HV5T@91061|Bacilli,26QSJ@186822|Paenibacillaceae	91061|Bacilli	T	Histidine Phosphotransfer domain	rpfC	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
MMS1_k127_2113651_4	933262.AXAM01000005_gene2468	4.519e-20	93.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_9,Response_reg
MMS1_k127_2114554_1	926569.ANT_17740	1.186e-49	185.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2G9GZ@200795|Chloroflexi	200795|Chloroflexi	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2
MMS1_k127_2114554_5	1122931.AUAE01000003_gene273	1.775e-24	110.0	COG4109@1|root,COG4109@2|Bacteria,4NTA0@976|Bacteroidetes,2FTZ6@200643|Bacteroidia,22YI5@171551|Porphyromonadaceae	976|Bacteroidetes	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
MMS1_k127_2114554_0	644282.Deba_1522	9.738e-57	207.0	COG0613@1|root,COG0613@2|Bacteria,1N68X@1224|Proteobacteria,42TYN@68525|delta/epsilon subdivisions,2WR34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PHP-associated	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP_C
MMS1_k127_2114554_4	584708.Apau_1783	4.257e-31	132.0	COG3290@1|root,COG3290@2|Bacteria,3TB0F@508458|Synergistetes	508458|Synergistetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
MMS1_k127_2114554_3	644282.Deba_1520	2.076e-41	155.0	COG3411@1|root,COG3411@2|Bacteria,1N1N9@1224|Proteobacteria,42U7G@68525|delta/epsilon subdivisions,2WQFG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS1_k127_2114554_2	177437.HRM2_16600	2.38e-43	162.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2MJ8N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.2,1.6.5.3	ko:K00124,ko:K00335,ko:K00355,ko:K18331	ko00130,ko00190,ko00630,ko00680,ko01100,ko01110,ko01120,ko01200,ko05200,ko05225,ko05418,map00130,map00190,map00630,map00680,map01100,map01110,map01120,map01200,map05200,map05225,map05418	M00144	R00519,R02964,R03643,R03816,R11945	RC00061,RC00819,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
MMS1_k127_2117066_2	1408287.AXUR01000018_gene501	2.084e-44	164.0	COG1028@1|root,COG1028@2|Bacteria,379JC@32066|Fusobacteria	32066|Fusobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
MMS1_k127_2117066_3	1163671.JAGI01000002_gene970	1.902e-43	161.0	COG3257@1|root,COG3257@2|Bacteria,1V6Z0@1239|Firmicutes,24K39@186801|Clostridia,36NXN@31979|Clostridiaceae	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_2117066_1	588581.Cpap_2789	9.58e-72	248.0	28JAU@1|root,2Z95P@2|Bacteria,1UPNR@1239|Firmicutes,25HK6@186801|Clostridia	186801|Clostridia	S	Mpv17 / PMP22 family	-	-	-	-	-	-	-	-	-	-	-	-	Mpv17_PMP22
MMS1_k127_2117066_0	1511.CLOST_0201	2.123e-127	414.0	COG0655@1|root,COG0655@2|Bacteria,1TQ8D@1239|Firmicutes,25CAN@186801|Clostridia	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_2117066_4	1123009.AUID01000016_gene60	1.884e-05	48.0	2EG7Z@1|root,339ZT@2|Bacteria,1VNA0@1239|Firmicutes,24FGJ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2121393_2	744872.Spica_0727	1.975e-66	233.0	COG0395@1|root,COG0395@2|Bacteria,2J65P@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10190	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	BPD_transp_1
MMS1_k127_2121393_1	744872.Spica_0726	2.811e-142	456.0	COG1175@1|root,COG1175@2|Bacteria,2J5N6@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10189	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	BPD_transp_1
MMS1_k127_2121393_0	744872.Spica_0725	1.908e-202	638.0	COG1653@1|root,COG1653@2|Bacteria,2J5ZH@203691|Spirochaetes	203691|Spirochaetes	G	solute-binding protein	-	-	-	ko:K10188	ko02010,map02010	M00199	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.4	-	-	SBP_bac_8
MMS1_k127_2122251_1	338966.Ppro_1609	3.9e-34	136.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,43UNN@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_2122251_0	573413.Spirs_2919	1.172e-61	215.0	COG2201@1|root,COG2201@2|Bacteria,2J7EW@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	cheY-3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
MMS1_k127_2122251_3	1304885.AUEY01000021_gene3467	3.362e-25	117.0	COG0745@1|root,COG0745@2|Bacteria,1N0XC@1224|Proteobacteria,42TRF@68525|delta/epsilon subdivisions,2WQDP@28221|Deltaproteobacteria,2MKTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
MMS1_k127_2122251_4	583355.Caka_0179	1.139e-17	87.0	COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,46TXM@74201|Verrucomicrobia,3K83U@414999|Opitutae	414999|Opitutae	NT	ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
MMS1_k127_2122251_5	1121104.AQXH01000001_gene1852	3.367e-08	59.0	COG2198@1|root,COG2198@2|Bacteria,4NVZN@976|Bacteroidetes,1IU8E@117747|Sphingobacteriia	976|Bacteroidetes	T	(Hpt) domain	-	-	-	-	-	-	-	-	-	-	-	-	Hpt
MMS1_k127_2122251_2	1410609.JHVB01000011_gene1632	3.848e-28	117.0	COG1716@1|root,COG1716@2|Bacteria,2J7PU@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG1716 FOG FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
MMS1_k127_2123388_12	1499967.BAYZ01000013_gene6426	2.312e-19	93.0	COG2188@1|root,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
MMS1_k127_2123388_6	1499967.BAYZ01000012_gene2485	4.14e-40	150.0	COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria	2|Bacteria	CQ	COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
MMS1_k127_2123388_1	1499967.BAYZ01000012_gene2484	2.233e-100	331.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	BMC
MMS1_k127_2123388_7	1499967.BAYZ01000012_gene2485	6.802e-39	147.0	COG4577@1|root,COG4577@2|Bacteria,2NRBW@2323|unclassified Bacteria	2|Bacteria	CQ	COGs COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein	-	-	-	ko:K04027	-	-	-	-	ko00000	-	-	-	BMC
MMS1_k127_2123388_8	1499967.BAYZ01000013_gene6419	4.628e-32	127.0	COG4576@1|root,COG4576@2|Bacteria,2NRNV@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	-	-	-	ko:K04028,ko:K08697	-	-	-	-	ko00000	-	-	-	EutN_CcmL
MMS1_k127_2123388_10	1499967.BAYZ01000013_gene6420	3.186e-25	111.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
MMS1_k127_2123388_0	1499967.BAYZ01000013_gene6421	1.907e-202	640.0	COG1012@1|root,COG1012@2|Bacteria,2NQI9@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde dehydrogenase family	eutE	GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.87	ko:K04021,ko:K13922	ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120	-	R00228,R09097	RC00004,RC00184,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS1_k127_2123388_9	1499967.BAYZ01000013_gene6422	8.703e-29	117.0	COG4576@1|root,COG4576@2|Bacteria,2NRYU@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
MMS1_k127_2123388_11	1499967.BAYZ01000013_gene6423	1.016e-21	98.0	COG4576@1|root,COG4576@2|Bacteria,2NS06@2323|unclassified Bacteria	2|Bacteria	CQ	Ethanolamine utilisation protein EutN/carboxysome	eutN	GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
MMS1_k127_2123388_3	1499967.BAYZ01000013_gene6424	1.024e-69	241.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
MMS1_k127_2123388_2	1499967.BAYZ01000013_gene6425	1.531e-91	308.0	COG0274@1|root,COG0274@2|Bacteria,2NP8Z@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	2.7.1.15,4.1.2.4	ko:K00852,ko:K01619	ko00030,map00030	-	R01051,R01066,R02750	RC00002,RC00017,RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
MMS1_k127_2123388_4	862908.BMS_0316	3.032e-64	230.0	COG2017@1|root,COG2017@2|Bacteria,1MVR4@1224|Proteobacteria,42USW@68525|delta/epsilon subdivisions,2MU55@213481|Bdellovibrionales,2WSX3@28221|Deltaproteobacteria	213481|Bdellovibrionales	G	Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
MMS1_k127_2123388_5	313628.LNTAR_21300	6.164e-45	167.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_2127891_0	278963.ATWD01000001_gene3714	1.782e-152	492.0	COG1415@1|root,COG1415@2|Bacteria,3Y6D2@57723|Acidobacteria,2JKZS@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
MMS1_k127_2127891_3	1033734.CAET01000016_gene4055	1.922e-55	204.0	COG2207@1|root,COG2207@2|Bacteria,1UZ8Y@1239|Firmicutes,4HJDY@91061|Bacilli,1ZFHE@1386|Bacillus	91061|Bacilli	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
MMS1_k127_2127891_1	376686.Fjoh_3114	7.959e-152	493.0	COG5434@1|root,COG5434@2|Bacteria,4NICS@976|Bacteroidetes,1I05A@117743|Flavobacteriia,2NU3J@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
MMS1_k127_2127891_5	697281.Mahau_1203	5.735e-05	51.0	2CI1K@1|root,2ZCW7@2|Bacteria,1W2BN@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2127891_2	349521.HCH_03519	1.712e-68	241.0	COG0834@1|root,COG0834@2|Bacteria,1RBXC@1224|Proteobacteria,1S528@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Amino acid ABC transporter substrate-binding protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_2127891_4	1536773.R70331_17750	3.914e-32	133.0	COG1653@1|root,COG1653@2|Bacteria,1TPBS@1239|Firmicutes,4IPRZ@91061|Bacilli,26UKJ@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_2128374_2	573413.Spirs_2062	1.123e-65	231.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J60C@203691|Spirochaetes	2|Bacteria	K	COGs COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_2128374_0	1218084.BBJK01000133_gene7182	4.326e-68	241.0	COG0780@1|root,COG2904@1|root,COG0780@2|Bacteria,COG2904@2|Bacteria,1MW0M@1224|Proteobacteria,2VINU@28216|Betaproteobacteria,1K0W9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF,QueF_N
MMS1_k127_2128374_1	357276.EL88_04140	1.771e-67	236.0	COG0603@1|root,COG0603@2|Bacteria,4NGCY@976|Bacteroidetes,2FM6W@200643|Bacteroidia,4AN1K@815|Bacteroidaceae	976|Bacteroidetes	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS1_k127_2128374_3	203119.Cthe_3107	3.162e-17	86.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,3WIJ6@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMS1_k127_2136393_2	906968.Trebr_1979	3.783e-09	68.0	2EMQ9@1|root,33FCS@2|Bacteria	2|Bacteria	S	Bacterial SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
MMS1_k127_2136393_1	1399115.U719_08225	9.852e-19	92.0	COG1670@1|root,COG1670@2|Bacteria,1V2C6@1239|Firmicutes,4HG3C@91061|Bacilli	91061|Bacilli	J	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
MMS1_k127_2136393_0	1123226.KB899279_gene2419	7.143e-27	117.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1V1RQ@1239|Firmicutes,4HJFX@91061|Bacilli,274E5@186822|Paenibacillaceae	91061|Bacilli	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
MMS1_k127_2141081_3	1385511.N783_00055	3.828e-73	268.0	COG2199@1|root,COG3706@2|Bacteria,1V4ZC@1239|Firmicutes,4HJTT@91061|Bacilli,2YBX5@289201|Pontibacillus	91061|Bacilli	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GGDEF
MMS1_k127_2141081_0	1195236.CTER_2861	2.123e-293	921.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,3WNNX@541000|Ruminococcaceae	186801|Clostridia	O	ATP-dependent protease La (LON) substrate-binding domain	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS1_k127_2141081_5	944479.JQLX01000013_gene1452	5.828e-39	159.0	COG2199@1|root,COG2199@2|Bacteria,1P82T@1224|Proteobacteria	1224|Proteobacteria	T	ggdef domain	-	-	2.7.7.65	ko:K20955	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,HAMP,PAS,dCache_1
MMS1_k127_2141081_1	158189.SpiBuddy_1610	3.352e-97	334.0	COG2223@1|root,COG2223@2|Bacteria,2J78Y@203691|Spirochaetes	203691|Spirochaetes	P	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2141081_4	387093.SUN_0951	5.812e-56	200.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2YPC4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
MMS1_k127_2141081_2	1487923.DP73_17540	7.091e-75	271.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia	186801|Clostridia	K	transcription activator, effector binding	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
MMS1_k127_2143782_2	573413.Spirs_2617	0.0004185	44.0	COG3359@1|root,COG3359@2|Bacteria,2J801@203691|Spirochaetes	203691|Spirochaetes	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
MMS1_k127_2143782_0	221027.JO40_11300	1.013e-173	557.0	COG0297@1|root,COG0297@2|Bacteria,2J5B0@203691|Spirochaetes	203691|Spirochaetes	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
MMS1_k127_2143782_1	754027.HMPREF9554_02167	1.863e-19	92.0	COG3393@1|root,COG3393@2|Bacteria,2J84J@203691|Spirochaetes	203691|Spirochaetes	S	Acetyltransferase GNAT family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
MMS1_k127_2144872_3	573413.Spirs_3694	1.048e-48	188.0	COG3568@1|root,COG3568@2|Bacteria,2J7FP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Endonuclease Exonuclease phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
MMS1_k127_2144872_1	1480694.DC28_04635	6.95e-88	294.0	COG0740@1|root,COG0740@2|Bacteria,2J78H@203691|Spirochaetes	203691|Spirochaetes	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP-2	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
MMS1_k127_2144872_0	1480694.DC28_04640	8.658e-99	330.0	COG1159@1|root,COG1159@2|Bacteria,2J671@203691|Spirochaetes	203691|Spirochaetes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
MMS1_k127_2144872_2	866895.HBHAL_1355	4.817e-57	208.0	COG2035@1|root,COG2035@2|Bacteria,1UYD5@1239|Firmicutes,4HBE3@91061|Bacilli,3NEJU@45667|Halobacillus	91061|Bacilli	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
MMS1_k127_2144872_4	573413.Spirs_0396	4.447e-36	140.0	COG1848@1|root,COG1848@2|Bacteria,2J7R7@203691|Spirochaetes	203691|Spirochaetes	S	SPTR PIN domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_3
MMS1_k127_2151209_1	545694.TREPR_3000	1.192e-144	466.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10542,ko:K10545,ko:K10548,ko:K17215	ko02010,map02010	M00214,M00215,M00216,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.3,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
MMS1_k127_2151209_0	1123274.KB899414_gene3675	2.637e-159	511.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
MMS1_k127_2151209_2	526224.Bmur_0380	2.257e-99	336.0	COG2008@1|root,COG2008@2|Bacteria,2J5XX@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
MMS1_k127_2151209_3	795359.TOPB45_0986	5.335e-97	332.0	COG0460@1|root,COG0460@2|Bacteria,2GH5Y@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
MMS1_k127_2151209_4	1121439.dsat_2216	0.0003087	50.0	COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HATPase_c_2,HisKA_2,PAS_9,dCache_2
MMS1_k127_2152898_0	1480694.DC28_07855	2.515e-60	220.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	aglR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
MMS1_k127_2152898_1	768066.HELO_1651	7.111e-16	81.0	COG3015@1|root,COG3187@1|root,COG3015@2|Bacteria,COG3187@2|Bacteria,1N9XV@1224|Proteobacteria,1S4T0@1236|Gammaproteobacteria,1XQDA@135619|Oceanospirillales	135619|Oceanospirillales	O	META domain	-	-	-	ko:K09914	-	-	-	-	ko00000	-	-	-	META,NlpE,NlpE_C,YscW
MMS1_k127_2154424_4	1408813.AYMG01000001_gene3364	2.95e-25	111.0	COG0583@1|root,COG0583@2|Bacteria,4NGZ5@976|Bacteroidetes,1IWWD@117747|Sphingobacteriia	976|Bacteroidetes	K	LysR substrate binding domain	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2154424_3	195103.CPF_2928	9.151e-37	141.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,36JKZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561
MMS1_k127_2154424_2	1408437.JNJN01000026_gene701	7.607e-45	167.0	COG4702@1|root,COG4702@2|Bacteria,1VBQP@1239|Firmicutes,24PFD@186801|Clostridia	186801|Clostridia	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
MMS1_k127_2154424_1	1009370.ALO_15252	3.776e-70	247.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes	909932|Negativicutes	IQ	reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_2154424_0	1499967.BAYZ01000179_gene4628	8.696e-156	501.0	COG4231@1|root,COG4231@2|Bacteria,2NP25@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
MMS1_k127_2155776_1	1307761.L21SP2_2345	1.203e-109	369.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J6C2@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C
MMS1_k127_2155776_3	889378.Spiaf_0165	1.003e-78	273.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2155776_0	889378.Spiaf_0164	9.987e-279	871.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2155776_4	517417.Cpar_0476	5.318e-16	91.0	COG0457@1|root,COG0457@2|Bacteria	517417.Cpar_0476|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2155776_2	889378.Spiaf_0091	1.003e-107	359.0	COG1306@1|root,COG1306@2|Bacteria,2J5BQ@203691|Spirochaetes	203691|Spirochaetes	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
MMS1_k127_2155870_2	1121403.AUCV01000067_gene2184	3.962e-35	139.0	COG4902@1|root,COG4902@2|Bacteria,1N5X3@1224|Proteobacteria,42TKU@68525|delta/epsilon subdivisions,2WQUZ@28221|Deltaproteobacteria,2MKSQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Possible catecholamine-binding domain present in a variety of eukaryotic proteins.	-	-	-	-	-	-	-	-	-	-	-	-	DOMON
MMS1_k127_2155870_0	1499689.CCNN01000007_gene1278	1.102e-92	306.0	COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,36EFS@31979|Clostridiaceae	186801|Clostridia	C	Rubrerythrin	rbr3A	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005506,GO:0006091,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009266,GO:0009268,GO:0009408,GO:0009409,GO:0009628,GO:0009636,GO:0009651,GO:0009987,GO:0010035,GO:0010446,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0016999,GO:0017001,GO:0017144,GO:0022900,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070417,GO:0070482,GO:0070887,GO:0071214,GO:0071236,GO:0071453,GO:0071467,GO:0071469,GO:0071470,GO:0071472,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:0104004,GO:1901700,GO:1901701,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS1_k127_2155870_1	1121324.CLIT_11c02490	9.622e-86	289.0	COG0436@1|root,COG0436@2|Bacteria,1TRA9@1239|Firmicutes,249X4@186801|Clostridia	186801|Clostridia	E	PFAM aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_2158294_4	1307761.L21SP2_0413	7.671e-107	354.0	COG0331@1|root,COG0331@2|Bacteria,2J5E6@203691|Spirochaetes	203691|Spirochaetes	I	Malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
MMS1_k127_2158294_1	1480694.DC28_06520	3.414e-184	584.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_2158294_6	1307761.L21SP2_0415	1.085e-86	293.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_2158294_2	1307761.L21SP2_0416	5.978e-169	542.0	COG3425@1|root,COG3425@2|Bacteria	2|Bacteria	I	synthase	pksG	-	2.3.3.10	ko:K01641,ko:K15311	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	ACP_syn_III_C,HMG_CoA_synt_C,HMG_CoA_synt_N
MMS1_k127_2158294_7	1307761.L21SP2_0417	1.691e-70	247.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	pksH	-	4.2.1.18	ko:K13766,ko:K15312	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	ECH_1
MMS1_k127_2158294_5	1480694.DC28_06540	2.522e-96	321.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	pksI	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	-	ko:K15313	-	-	-	-	ko00000,ko01008	-	-	-	ECH_1
MMS1_k127_2158294_3	1307761.L21SP2_0419	3.075e-109	359.0	COG1028@1|root,COG1028@2|Bacteria	1307761.L21SP2_0419|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2158294_10	1307761.L21SP2_0420	1.46e-29	119.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpK	-	-	ko:K02078,ko:K15337	-	-	-	-	ko00000,ko00001,ko01008	-	-	-	PP-binding
MMS1_k127_2158294_0	1307761.L21SP2_0421	1.091e-199	629.0	COG0156@1|root,COG0156@2|Bacteria,2J615@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_2158294_9	1307761.L21SP2_0422	2.238e-47	175.0	COG0764@1|root,COG0764@2|Bacteria	2|Bacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
MMS1_k127_2158294_8	1540257.JQMW01000009_gene2836	1.294e-52	197.0	COG2199@1|root,COG2199@2|Bacteria,1V5WD@1239|Firmicutes,249N6@186801|Clostridia,36HFR@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HisKA_7TM,PAS_9
MMS1_k127_2163218_1	545695.TREAZ_0756	1.222e-27	120.0	COG3359@1|root,COG3359@2|Bacteria,2J801@203691|Spirochaetes	203691|Spirochaetes	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
MMS1_k127_2163218_0	573413.Spirs_2618	6.15e-307	957.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,2J5DK@203691|Spirochaetes	203691|Spirochaetes	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
MMS1_k127_2164133_0	1120998.AUFC01000002_gene2709	9.296e-181	580.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia	186801|Clostridia	K	sigma54 specific, transcriptional regulator, Fis family	aorR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
MMS1_k127_2164407_4	573413.Spirs_3787	2.418e-69	246.0	COG2114@1|root,COG2114@2|Bacteria,2J9VX@203691|Spirochaetes	203691|Spirochaetes	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2164407_7	649747.HMPREF0083_02827	1.834e-42	163.0	COG2230@1|root,COG2230@2|Bacteria,1UMJ8@1239|Firmicutes,4HW8V@91061|Bacilli	91061|Bacilli	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS1_k127_2164407_5	545695.TREAZ_0708	2.052e-66	237.0	COG0030@1|root,COG0030@2|Bacteria,2J65T@203691|Spirochaetes	203691|Spirochaetes	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMS1_k127_2164407_11	388413.ALPR1_05295	1.012e-17	97.0	COG0658@1|root,COG0658@2|Bacteria,4NEJH@976|Bacteroidetes,47K9X@768503|Cytophagia	976|Bacteroidetes	S	TIGRFAM ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
MMS1_k127_2164407_6	1123274.KB899409_gene433	8.449e-54	204.0	COG1413@1|root,COG1413@2|Bacteria,2J5TA@203691|Spirochaetes	203691|Spirochaetes	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2164407_14	1168034.FH5T_19795	0.0003464	51.0	COG3209@1|root,COG3209@2|Bacteria,4NWB3@976|Bacteroidetes	976|Bacteroidetes	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2164407_2	889378.Spiaf_2209	1.594e-74	264.0	COG5581@1|root,COG5581@2|Bacteria,2J6AM@203691|Spirochaetes	203691|Spirochaetes	M	Type IV pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
MMS1_k127_2164407_10	573413.Spirs_1504	3.957e-23	107.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	3.4.11.19	ko:K01266,ko:K07052	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abi
MMS1_k127_2164407_9	158190.SpiGrapes_1288	4.93e-29	121.0	2DRM1@1|root,33C8J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2164407_8	158190.SpiGrapes_1290	3.387e-34	134.0	COG3877@1|root,COG3877@2|Bacteria,2JB25@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
MMS1_k127_2164407_3	573413.Spirs_1013	8.046e-73	256.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
MMS1_k127_2164407_0	1410653.JHVC01000006_gene220	1.259e-244	772.0	COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia,36E9Y@31979|Clostridiaceae	186801|Clostridia	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3	fbp	-	3.1.3.11	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_2
MMS1_k127_2164407_13	754027.HMPREF9554_00727	4.66e-09	69.0	COG0797@1|root,COG0797@2|Bacteria,2J7K2@203691|Spirochaetes	203691|Spirochaetes	M	Sporulation and cell division repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
MMS1_k127_2164407_12	1123274.KB899409_gene604	3.814e-10	73.0	COG0797@1|root,COG0797@2|Bacteria	2|Bacteria	M	peptidoglycan binding	ydjM	-	-	-	-	-	-	-	-	-	-	-	DPBB_1,LysM,SPOR
MMS1_k127_2164407_1	906968.Trebr_1756	4.889e-113	373.0	COG1086@1|root,COG1086@2|Bacteria,2J5C2@203691|Spirochaetes	203691|Spirochaetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,CoA_binding_3,Polysacc_synt_2
MMS1_k127_216742_2	665571.STHERM_c04740	1.047e-35	138.0	COG0426@1|root,COG0426@2|Bacteria,2J589@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5,Lactamase_B
MMS1_k127_216742_0	573413.Spirs_0020	3.673e-73	251.0	COG0426@1|root,COG0426@2|Bacteria,2J589@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5,Lactamase_B
MMS1_k127_216742_1	645991.Sgly_2352	1.952e-67	241.0	COG1456@1|root,COG1456@2|Bacteria,1TPYJ@1239|Firmicutes,2588C@186801|Clostridia,2601E@186807|Peptococcaceae	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
MMS1_k127_2168847_0	698758.AXY_22860	1.097e-132	429.0	COG1120@1|root,COG1472@1|root,COG1120@2|Bacteria,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2168847_2	1499685.CCFJ01000012_gene1794	2.479e-89	299.0	28NMC@1|root,2ZBMX@2|Bacteria,1V1DV@1239|Firmicutes,4HTUB@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
MMS1_k127_2168847_1	397288.C806_03344	2.471e-127	416.0	COG0463@1|root,COG0463@2|Bacteria,1TT6C@1239|Firmicutes,248F2@186801|Clostridia,27JTS@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Glycosyl transferase family 2	kfoC_2	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_2168847_3	1120947.ATUX01000007_gene1027	6.387e-26	112.0	COG1472@1|root,COG1472@2|Bacteria,2GQQR@201174|Actinobacteria,4D4U9@85005|Actinomycetales	201174|Actinobacteria	G	Glycosyl hydrolase family 3 N-terminal domain protein	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2169515_0	530564.Psta_3290	2.562e-65	240.0	COG5316@1|root,COG5316@2|Bacteria,2IY3B@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
MMS1_k127_2169515_1	1122975.AQVC01000010_gene1563	4.813e-43	163.0	COG1033@1|root,COG1033@2|Bacteria,4NKHV@976|Bacteroidetes,2FNS1@200643|Bacteroidia,22XXF@171551|Porphyromonadaceae	976|Bacteroidetes	S	Patched family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_2171108_0	156889.Mmc1_2999	1.516e-61	220.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	CP_0258	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
MMS1_k127_2171108_2	161156.JQKW01000010_gene317	3.122e-15	78.0	COG0840@1|root,COG0840@2|Bacteria,2GHNV@200940|Thermodesulfobacteria	2|Bacteria	NT	Four helix bundle sensory module for signal transduction	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_2
MMS1_k127_2171516_0	1265503.KB905173_gene4180	9.513e-46	175.0	COG0834@1|root,COG0834@2|Bacteria,1NCKT@1224|Proteobacteria,1SD6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_2171516_1	1265503.KB905173_gene4180	1.764e-41	162.0	COG0834@1|root,COG0834@2|Bacteria,1NCKT@1224|Proteobacteria,1SD6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_2171516_2	1123366.TH3_19064	1.059e-33	136.0	COG0834@1|root,COG0834@2|Bacteria,1RCKU@1224|Proteobacteria,2U6QD@28211|Alphaproteobacteria,2JTW2@204441|Rhodospirillales	204441|Rhodospirillales	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_2172131_1	1307761.L21SP2_1968	7.754e-145	464.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	MA20_22595	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
MMS1_k127_2172131_0	452637.Oter_1863	7.64e-156	501.0	COG0563@1|root,COG0563@2|Bacteria,46SW4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
MMS1_k127_2172131_2	635013.TherJR_0639	2.432e-62	226.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,2634Y@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
MMS1_k127_2172131_3	1122135.KB893171_gene2062	2.044e-30	122.0	COG1279@1|root,COG1279@2|Bacteria,1RD6B@1224|Proteobacteria,2U583@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1279 Lysine efflux permease	argO	-	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
MMS1_k127_2172955_4	573370.DMR_27210	7.812e-74	254.0	COG2197@1|root,COG2197@2|Bacteria,1R116@1224|Proteobacteria	1224|Proteobacteria	KT	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	MEDS
MMS1_k127_2172955_2	1121451.DESAM_20883	5.11e-114	391.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_2172955_0	889378.Spiaf_0166	8.877e-283	893.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J6C2@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C
MMS1_k127_2172955_3	889378.Spiaf_0165	9.177e-76	264.0	2F0EQ@1|root,33THS@2|Bacteria,2J5ZQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2172955_1	1307761.L21SP2_2342	6.438e-136	442.0	2EZDZ@1|root,33SJ6@2|Bacteria,2J6M2@203691|Spirochaetes	203691|Spirochaetes	S	Cytoplasmic filament protein A	cfpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2174_1	435591.BDI_3385	1.024e-58	216.0	COG2755@1|root,COG2755@2|Bacteria,4NFN6@976|Bacteroidetes,2FKZ2@200643|Bacteroidia,22W3N@171551|Porphyromonadaceae	976|Bacteroidetes	E	GSCFA family	-	-	-	-	-	-	-	-	-	-	-	-	GSCFA
MMS1_k127_2174_0	1480694.DC28_14925	5.082e-157	507.0	COG2239@1|root,COG2239@2|Bacteria,2J5VW@203691|Spirochaetes	203691|Spirochaetes	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
MMS1_k127_2174_2	314723.BH0598	1.735e-56	203.0	COG0812@1|root,COG0812@2|Bacteria,2J5SE@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
MMS1_k127_2174257_0	744872.Spica_0010	6.768e-128	413.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
MMS1_k127_2174257_1	744872.Spica_1127	7.427e-128	416.0	COG1344@1|root,COG1344@2|Bacteria,2J5NR@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
MMS1_k127_2174257_2	1304888.ATWF01000002_gene373	7.015e-06	52.0	COG1334@1|root,COG1334@2|Bacteria,2GG1A@200930|Deferribacteres	200930|Deferribacteres	N	FlaG protein	-	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
MMS1_k127_2174509_1	1123274.KB899432_gene2929	1.092e-57	207.0	COG0569@1|root,COG0569@2|Bacteria,2J72B@203691|Spirochaetes	203691|Spirochaetes	C	domain protein	tkrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
MMS1_k127_2174509_0	573413.Spirs_3978	4.798e-144	476.0	COG0168@1|root,COG0168@2|Bacteria,2J5NF@203691|Spirochaetes	203691|Spirochaetes	P	Potassium uptake protein, TrkH family	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMS1_k127_2174570_2	177437.HRM2_01520	5.737e-15	79.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,42MFS@68525|delta/epsilon subdivisions,2WJPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Fumarate lyase	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS1_k127_2174570_1	1304874.JAFY01000002_gene972	9.787e-141	457.0	COG0486@1|root,COG0486@2|Bacteria,3TA5Q@508458|Synergistetes	508458|Synergistetes	S	small GTP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
MMS1_k127_2174570_0	877418.ATWV01000001_gene1556	1.325e-177	564.0	COG0104@1|root,COG0104@2|Bacteria,2J6B6@203691|Spirochaetes	203691|Spirochaetes	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMS1_k127_2174570_3	1027273.GZ77_13630	3.921e-10	63.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,1SCSV@1236|Gammaproteobacteria,1XMJS@135619|Oceanospirillales	135619|Oceanospirillales	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
MMS1_k127_2183492_3	1547445.LO80_00820	0.0008714	46.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,1S61Y@1236|Gammaproteobacteria,46187@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
MMS1_k127_2183492_1	744872.Spica_0296	7.905e-166	565.0	COG0642@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,Hpt,Reg_prop,Response_reg,Y_Y_Y
MMS1_k127_2183492_0	1132442.KB889752_gene451	3.827e-210	676.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,4HCXR@91061|Bacilli,1ZRHZ@1386|Bacillus	91061|Bacilli	G	Glycosyl hydrolases family 2, TIM barrel domain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_2183492_2	1235835.C814_01347	2.313e-164	527.0	COG2211@1|root,COG2211@2|Bacteria,1TRYR@1239|Firmicutes,25C8G@186801|Clostridia,3WIZ4@541000|Ruminococcaceae	186801|Clostridia	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
MMS1_k127_2185391_0	545694.TREPR_1652	8.34e-150	484.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,2J5CT@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD
MMS1_k127_2185391_2	1499967.BAYZ01000194_gene3126	1.213e-23	102.0	COG4627@1|root,COG4627@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
MMS1_k127_2185391_1	889378.Spiaf_1720	6.898e-73	250.0	COG0522@1|root,COG0522@2|Bacteria,2J6UK@203691|Spirochaetes	203691|Spirochaetes	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMS1_k127_2188325_2	1121403.AUCV01000017_gene4504	1.407e-06	53.0	COG1309@1|root,COG1309@2|Bacteria,1RJH4@1224|Proteobacteria,42T42@68525|delta/epsilon subdivisions,2WPEX@28221|Deltaproteobacteria,2MKVB@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_2188325_0	1123242.JH636434_gene3396	8.299e-57	207.0	COG4221@1|root,COG4221@2|Bacteria,2IYGT@203682|Planctomycetes	203682|Planctomycetes	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_2188325_1	1123024.AUII01000024_gene204	1.564e-50	190.0	COG2084@1|root,COG2084@2|Bacteria,2GTGE@201174|Actinobacteria,4E7CY@85010|Pseudonocardiales	201174|Actinobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
MMS1_k127_2188325_3	411463.EUBVEN_01638	0.0006993	48.0	COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,248J7@186801|Clostridia,25UQS@186806|Eubacteriaceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
MMS1_k127_2189007_1	555079.Toce_1178	1.123e-61	227.0	COG2006@1|root,COG2768@1|root,COG2006@2|Bacteria,COG2768@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,42F8W@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
MMS1_k127_2189007_0	1121396.KB893059_gene2821	5.143e-112	377.0	COG3437@1|root,COG3437@2|Bacteria,1NTDW@1224|Proteobacteria,42N8P@68525|delta/epsilon subdivisions,2WKW9@28221|Deltaproteobacteria,2MIEQ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
MMS1_k127_2189007_2	1125725.HMPREF1325_0701	2.664e-32	126.0	COG0231@1|root,COG0231@2|Bacteria,2J69Z@203691|Spirochaetes	203691|Spirochaetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
MMS1_k127_2189686_1	744872.Spica_0849	1.373e-103	342.0	COG0568@1|root,COG0568@2|Bacteria,2J7R0@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086,ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_2189686_0	906968.Trebr_1828	1.13e-147	474.0	COG0533@1|root,COG0533@2|Bacteria,2J5WG@203691|Spirochaetes	203691|Spirochaetes	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
MMS1_k127_2189686_2	573413.Spirs_1797	1.698e-52	193.0	COG0455@1|root,COG0455@2|Bacteria,2J79I@203691|Spirochaetes	203691|Spirochaetes	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	ylxH-3	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA
MMS1_k127_2197289_1	1307761.L21SP2_2102	8.578e-93	308.0	COG0480@1|root,COG0480@2|Bacteria,2J5YJ@203691|Spirochaetes	203691|Spirochaetes	J	translation elongation factor	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_2197289_4	765913.ThidrDRAFT_4496	8.117e-42	169.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria,1WW1I@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
MMS1_k127_2197289_0	264732.Moth_1122	4.912e-185	589.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,42HUS@68295|Thermoanaerobacterales	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS1_k127_2197289_2	1410609.JHVB01000001_gene1803	5.231e-75	258.0	COG0220@1|root,COG0220@2|Bacteria,2J5YX@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
MMS1_k127_2197289_3	889378.Spiaf_0205	2.072e-44	173.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
MMS1_k127_2203604_0	293826.Amet_3665	1.75e-155	502.0	COG4187@1|root,COG4187@2|Bacteria,1TQQ7@1239|Firmicutes,249CV@186801|Clostridia,36EX1@31979|Clostridiaceae	186801|Clostridia	E	Peptidase family M20/M25/M40	rocB	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M20
MMS1_k127_2203604_1	935836.JAEL01000079_gene108	4.797e-82	280.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,4HB6V@91061|Bacilli,1ZB50@1386|Bacillus	91061|Bacilli	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short,adh_short_C2
MMS1_k127_2203604_2	138119.DSY2491	8.504e-74	257.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,261F6@186807|Peptococcaceae	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS1_k127_2211576_1	545694.TREPR_1659	8.016e-69	246.0	COG2201@1|root,COG2201@2|Bacteria,2J6JE@203691|Spirochaetes	203691|Spirochaetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
MMS1_k127_2211576_2	877418.ATWV01000008_gene693	3.858e-40	166.0	COG1352@1|root,COG1352@2|Bacteria,2J6YI@203691|Spirochaetes	203691|Spirochaetes	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
MMS1_k127_2211576_0	877418.ATWV01000009_gene342	1.645e-106	365.0	COG0643@1|root,COG0643@2|Bacteria,2J5GK@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
MMS1_k127_2219226_6	1196323.ALKF01000124_gene4690	2.414e-06	60.0	COG3547@1|root,COG3547@2|Bacteria,1TP4A@1239|Firmicutes,4HDAB@91061|Bacilli,26R4G@186822|Paenibacillaceae	91061|Bacilli	L	Transposase, IS116	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
MMS1_k127_2219226_5	1500281.JQKZ01000009_gene3094	5.263e-07	51.0	COG0010@1|root,COG0010@2|Bacteria,4NJ0J@976|Bacteroidetes,1HZS4@117743|Flavobacteriia,3ZNT8@59732|Chryseobacterium	976|Bacteroidetes	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS1_k127_2219226_1	1304885.AUEY01000023_gene2673	5.687e-52	194.0	COG0583@1|root,COG0583@2|Bacteria,1MV0E@1224|Proteobacteria,42SGR@68525|delta/epsilon subdivisions,2WPDS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2219226_0	1317122.ATO12_01050	3.135e-59	208.0	COG0607@1|root,COG0607@2|Bacteria,4NPEU@976|Bacteroidetes,1I2CS@117743|Flavobacteriia,2YJGG@290174|Aquimarina	976|Bacteroidetes	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
MMS1_k127_2219226_3	386456.JQKN01000005_gene452	2.835e-22	100.0	arCOG02240@1|root,arCOG02240@2157|Archaea	2157|Archaea	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase,Tautomerase_2
MMS1_k127_2219226_4	641491.DND132_2294	4.68e-12	70.0	COG0583@1|root,COG0583@2|Bacteria,1MV0E@1224|Proteobacteria,42SGR@68525|delta/epsilon subdivisions,2WPDS@28221|Deltaproteobacteria,2MBMQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2223873_1	1541065.JRFE01000022_gene4051	4.046e-54	194.0	COG1045@1|root,COG1045@2|Bacteria,1G5AN@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Bacterial transferase hexapeptide (three repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
MMS1_k127_2223873_2	1112216.JH594425_gene1919	2.09e-12	78.0	2FHE9@1|root,3498E@2|Bacteria,1NZTA@1224|Proteobacteria,2UU5Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMS1_k127_2223873_0	588581.Cpap_4106	1.052e-192	624.0	COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia	186801|Clostridia	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	ko:K13611	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
MMS1_k127_2225608_1	573413.Spirs_2455	1.293e-51	185.0	COG0636@1|root,COG0636@2|Bacteria,2J7GW@203691|Spirochaetes	203691|Spirochaetes	C	ATP synthase subunit K	atpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS1_k127_2225608_0	1123274.KB899419_gene1959	5.084e-93	313.0	COG1269@1|root,COG1269@2|Bacteria,2J594@203691|Spirochaetes	203691|Spirochaetes	C	V-type ATP synthase, subunit I	atpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS1_k127_2232089_5	40041.SZO_15130	4.785e-06	48.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli,1M90B@119603|Streptococcus dysgalactiae group	91061|Bacilli	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015608,GO:0015611,GO:0015749,GO:0015750,GO:0015752,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043211,GO:0043492,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_2232089_3	1041138.KB890221_gene1040	6.488e-94	317.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria,4BARC@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Ribose xylose arabinose galactoside ABC-type transport systems, permease components	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944	-	ko:K02057,ko:K10440,ko:K17206,ko:K17214	ko02010,map02010	M00212,M00221,M00591,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.15,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_2232089_1	33035.JPJF01000024_gene3204	3.652e-138	446.0	COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,24FFY@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_2232089_0	1116375.VEJY3_08610	3.349e-182	572.0	COG1082@1|root,COG1082@2|Bacteria,1MW1Z@1224|Proteobacteria,1RZT0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
MMS1_k127_2232089_4	1353537.TP2_15325	7.049e-36	138.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
MMS1_k127_2232089_2	1116375.VEJY3_08685	1.153e-96	323.0	COG4130@1|root,COG4130@2|Bacteria,1PC6C@1224|Proteobacteria,1RQDK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	isomerase	iolI	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
MMS1_k127_2232782_6	1541959.KQ51_00678	6.955e-26	113.0	COG2199@1|root,COG2199@2|Bacteria,3WUQV@544448|Tenericutes	544448|Tenericutes	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_2232782_7	1207063.P24_03725	1.865e-20	96.0	COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2UBRH@28211|Alphaproteobacteria,2JU0I@204441|Rhodospirillales	204441|Rhodospirillales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS1_k127_2232782_5	1194972.MVAC_10367	2.684e-53	192.0	COG3832@1|root,COG3832@2|Bacteria,2IH2T@201174|Actinobacteria,238V6@1762|Mycobacteriaceae	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS1_k127_2232782_4	1347369.CCAD010000094_gene2221	2.7e-78	263.0	2C3KP@1|root,2Z802@2|Bacteria,1TQD1@1239|Firmicutes,4HBGA@91061|Bacilli,1ZC7G@1386|Bacillus	91061|Bacilli	S	Phage tail protein	yjhE	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2232782_8	234267.Acid_0571	1.717e-18	89.0	COG0346@1|root,COG0346@2|Bacteria,3Y85T@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS1_k127_2232782_3	158189.SpiBuddy_0763	3.215e-128	417.0	COG2207@1|root,COG2207@2|Bacteria,2JB9A@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2232782_0	158189.SpiBuddy_0762	3.539e-224	701.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_2232782_1	1499967.BAYZ01000026_gene1614	4.148e-143	465.0	COG2268@1|root,COG2268@2|Bacteria,2NPBZ@2323|unclassified Bacteria	2|Bacteria	S	prohibitin homologues	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
MMS1_k127_2232782_2	1499967.BAYZ01000026_gene1615	5.582e-132	434.0	COG2268@1|root,COG2268@2|Bacteria,2NPBZ@2323|unclassified Bacteria	2|Bacteria	S	prohibitin homologues	yuaG	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
MMS1_k127_2233785_0	1515615.HQ41_02785	3.634e-13	78.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Gram_pos_anchor,Peptidase_M73
MMS1_k127_2234246_1	574087.Acear_0362	3.019e-53	198.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WAC6@53433|Halanaerobiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_7,Fer4_9,NQRA_SLBB,RnfC_N
MMS1_k127_2234246_0	574087.Acear_0363	4.951e-111	368.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3WA9X@53433|Halanaerobiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
MMS1_k127_2234246_2	1408417.JHYB01000003_gene281	2.657e-26	115.0	COG2869@1|root,COG2869@2|Bacteria	2|Bacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
MMS1_k127_2237028_0	768704.Desmer_2936	1.688e-142	455.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,260KD@186807|Peptococcaceae	186801|Clostridia	C	Biotin and Thiamin Synthesis associated	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
MMS1_k127_2237028_1	293826.Amet_1570	1.134e-16	80.0	COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,36HFJ@31979|Clostridiaceae	186801|Clostridia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
MMS1_k127_2237683_0	744872.Spica_1248	7.589e-82	277.0	COG0448@1|root,COG0448@2|Bacteria,2J5UB@203691|Spirochaetes	203691|Spirochaetes	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS1_k127_2237683_3	754027.HMPREF9554_00051	7.358e-13	74.0	2FBAD@1|root,343GE@2|Bacteria,2J7WU@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2237683_1	545695.TREAZ_0640	3.138e-31	128.0	COG1051@1|root,COG1051@2|Bacteria,2J8CP@203691|Spirochaetes	203691|Spirochaetes	F	PFAM NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4
MMS1_k127_2238738_4	56780.SYN_02377	1.666e-12	68.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MS9E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
MMS1_k127_2238738_0	545694.TREPR_2813	1.686e-273	861.0	COG0542@1|root,COG0542@2|Bacteria,2J6BU@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
MMS1_k127_2238738_2	1313301.AUGC01000004_gene2290	1.799e-75	261.0	COG2360@1|root,COG2360@2|Bacteria,4NG3A@976|Bacteroidetes	976|Bacteroidetes	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
MMS1_k127_2238738_1	886379.AEWI01000005_gene908	5.196e-113	382.0	COG0827@1|root,COG0827@2|Bacteria,4NM4C@976|Bacteroidetes,2FZ51@200643|Bacteroidia,3XKR4@558415|Marinilabiliaceae	976|Bacteroidetes	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
MMS1_k127_2238738_3	870967.VIS19158_09527	3.865e-26	121.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1XUTA@135623|Vibrionales	135623|Vibrionales	S	membrane	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
MMS1_k127_2240017_0	545695.TREAZ_3555	3.775e-130	437.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
MMS1_k127_2242424_0	1047013.AQSP01000125_gene2610	6.43e-116	388.0	COG4584@1|root,COG4584@2|Bacteria	2|Bacteria	L	PFAM Integrase catalytic	tnpA	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,rve
MMS1_k127_2242424_2	1410653.JHVC01000001_gene1888	1.222e-60	216.0	COG0500@1|root,COG2226@2|Bacteria,1UW06@1239|Firmicutes,25EJR@186801|Clostridia,36UUH@31979|Clostridiaceae	186801|Clostridia	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_31
MMS1_k127_2242424_1	1121904.ARBP01000003_gene6219	2.779e-84	287.0	COG1131@1|root,COG1131@2|Bacteria,4NFRV@976|Bacteroidetes,47N9E@768503|Cytophagia	976|Bacteroidetes	V	ABC-type multidrug transport system ATPase component	cbiO	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_2242424_4	1121904.ARBP01000003_gene6218	7.832e-22	106.0	2E4AF@1|root,30WV9@2|Bacteria,4NW70@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2242424_3	1270196.JCKI01000001_gene4140	2.472e-36	140.0	COG1725@1|root,COG1725@2|Bacteria,4NT1X@976|Bacteroidetes,1IT33@117747|Sphingobacteriia	976|Bacteroidetes	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR
MMS1_k127_2243256_0	573413.Spirs_2747	1.437e-88	300.0	COG5012@1|root,COG5012@2|Bacteria,2JBHI@203691|Spirochaetes	203691|Spirochaetes	S	Dimethylamine corrinoid protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
MMS1_k127_2243256_1	931276.Cspa_c22730	5.999e-55	201.0	COG0730@1|root,COG0730@2|Bacteria,1UCVY@1239|Firmicutes,24BST@186801|Clostridia,36RJG@31979|Clostridiaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS1_k127_2243256_2	545696.HOLDEFILI_00187	4.066e-20	94.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
MMS1_k127_2243880_3	933262.AXAM01000088_gene303	4.931e-58	205.0	COG4636@1|root,COG4636@2|Bacteria,1R58B@1224|Proteobacteria,42S3V@68525|delta/epsilon subdivisions,2WN8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
MMS1_k127_2243880_0	1123274.KB899415_gene2508	5.24e-117	389.0	COG0301@1|root,COG0301@2|Bacteria,2J64Z@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
MMS1_k127_2243880_4	573413.Spirs_1898	2.551e-24	103.0	COG2331@1|root,COG2331@2|Bacteria,2J904@203691|Spirochaetes	203691|Spirochaetes	S	FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
MMS1_k127_2243880_2	933262.AXAM01000088_gene303	2.499e-64	228.0	COG4636@1|root,COG4636@2|Bacteria,1R58B@1224|Proteobacteria,42S3V@68525|delta/epsilon subdivisions,2WN8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
MMS1_k127_2243880_1	665571.STHERM_c15890	1.034e-79	269.0	COG0107@1|root,COG0107@2|Bacteria,2J6FB@203691|Spirochaetes	203691|Spirochaetes	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMS1_k127_2245348_2	1449050.JNLE01000003_gene1602	1.051e-65	232.0	COG0348@1|root,COG0348@2|Bacteria,1V66G@1239|Firmicutes,25IKG@186801|Clostridia,36IJF@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_9
MMS1_k127_2245348_7	1345697.M493_02125	3.05e-09	68.0	COG2197@1|root,COG4936@1|root,COG2197@2|Bacteria,COG4936@2|Bacteria,1V2GV@1239|Firmicutes,4HGV4@91061|Bacilli,1WEVC@129337|Geobacillus	91061|Bacilli	K	Sensory domain found in PocR	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GerE,PocR
MMS1_k127_2245348_3	1123274.KB899408_gene3947	1.645e-63	232.0	COG1014@1|root,COG1014@2|Bacteria,2J8M0@203691|Spirochaetes	203691|Spirochaetes	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMS1_k127_2245348_1	1123274.KB899408_gene3946	2.55e-125	404.0	COG1013@1|root,COG1013@2|Bacteria,2J6R4@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase beta subunit	-	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00175,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS1_k127_2245348_0	573413.Spirs_0610	3.247e-150	482.0	COG0674@1|root,COG0674@2|Bacteria,2J65R@203691|Spirochaetes	203691|Spirochaetes	C	oxidoreductase, alpha subunit	porA6	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00174,ko:K00186	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMS1_k127_2245348_6	877418.ATWV01000009_gene366	9.367e-22	96.0	COG1146@1|root,COG1146@2|Bacteria,2J9EV@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S binding domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7
MMS1_k127_2245348_5	221027.JO40_08835	1.231e-42	161.0	COG1671@1|root,COG1671@2|Bacteria,2J84V@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
MMS1_k127_2245348_4	933262.AXAM01000043_gene1195	2.721e-43	164.0	COG1482@1|root,COG1482@2|Bacteria,1MUD8@1224|Proteobacteria,42QR1@68525|delta/epsilon subdivisions,2WU24@28221|Deltaproteobacteria,2MMJP@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphomannose isomerase type I	-	-	5.3.1.8,5.4.2.8	ko:K01809,ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818,R01819	RC00376,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
MMS1_k127_2245733_2	1123274.KB899427_gene3350	1.769e-41	157.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
MMS1_k127_2245733_0	926569.ANT_22700	1.632e-226	717.0	COG1132@1|root,COG1132@2|Bacteria,2G7KA@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2245733_1	926569.ANT_22690	7.356e-193	618.0	COG1132@1|root,COG1132@2|Bacteria,2G7KM@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2247921_2	562743.JH976434_gene1337	1.088e-44	164.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H9VK@91061|Bacilli	91061|Bacilli	G	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	xylG	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
MMS1_k127_2247921_0	553973.CLOHYLEM_05717	2.355e-107	359.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,21XJ5@1506553|Lachnoclostridium	186801|Clostridia	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	rbsA	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
MMS1_k127_2247921_1	1041138.KB890221_gene1039	1.588e-75	263.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TW5I@28211|Alphaproteobacteria,4BIEQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein-like domain	MA20_14320	-	-	ko:K10439,ko:K17202,ko:K17205,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00590,M00591,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.11,3.A.1.2.13,3.A.1.2.15,3.A.1.2.16,3.A.1.2.19	-	-	Peripla_BP_4
MMS1_k127_2248036_1	1379698.RBG1_1C00001G0558	4.556e-16	94.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Calx-beta,FG-GAP,VCBS
MMS1_k127_2248036_0	1123274.KB899436_gene1281	1.506e-162	570.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
MMS1_k127_2251230_2	545695.TREAZ_2863	3.467e-30	137.0	COG1196@1|root,COG1196@2|Bacteria,2J663@203691|Spirochaetes	203691|Spirochaetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2251230_1	573413.Spirs_0913	1.061e-43	164.0	COG3216@1|root,COG3216@2|Bacteria,2J82S@203691|Spirochaetes	203691|Spirochaetes	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2062
MMS1_k127_2251230_0	1313304.CALK_2274	8.139e-100	342.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_2252118_14	573370.DMR_02070	9.421e-36	141.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg,sCache_2
MMS1_k127_2252118_3	342113.DM82_2082	4.362e-127	417.0	COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,2VGZ5@28216|Betaproteobacteria,1K2JW@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
MMS1_k127_2252118_8	1499967.BAYZ01000075_gene2071	4.189e-75	271.0	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS-HPr
MMS1_k127_2252118_11	1480694.DC28_14035	9.98e-43	165.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	nnrR	-	-	ko:K01420,ko:K21564	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_2252118_1	1347392.CCEZ01000008_gene2145	6.999e-144	467.0	COG1840@1|root,COG1840@2|Bacteria,1TYKR@1239|Firmicutes,249E2@186801|Clostridia,36G38@31979|Clostridiaceae	186801|Clostridia	P	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,SBP_bac_6
MMS1_k127_2252118_5	469616.FMAG_00137	2.133e-120	389.0	COG0378@1|root,COG0378@2|Bacteria,379PF@32066|Fusobacteria	32066|Fusobacteria	KO	CobW P47K family protein	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMS1_k127_2252118_2	1321779.HMPREF1984_01613	9.64e-131	427.0	COG1136@1|root,COG1136@2|Bacteria,379EK@32066|Fusobacteria	32066|Fusobacteria	V	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
MMS1_k127_2252118_6	1392491.JIAE01000001_gene1818	4.214e-108	362.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,3WJ5B@541000|Ruminococcaceae	186801|Clostridia	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
MMS1_k127_2252118_13	522772.Dacet_0091	4.352e-36	138.0	2CG49@1|root,32Y3Y@2|Bacteria,2GG2B@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2252118_12	1189619.pgond44_10231	4.177e-39	153.0	COG0526@1|root,COG0526@2|Bacteria,4NNU2@976|Bacteroidetes,1I22P@117743|Flavobacteriia,4C3SX@83612|Psychroflexus	976|Bacteroidetes	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
MMS1_k127_2252118_10	1124780.ANNU01000061_gene915	2.618e-44	170.0	COG3022@1|root,COG3022@2|Bacteria,4NFP2@976|Bacteroidetes,47Q7T@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the UPF0246 family	-	-	-	ko:K09861	-	-	-	-	ko00000	-	-	-	H2O2_YaaD
MMS1_k127_2252118_0	1307761.L21SP2_2126	9.005e-182	579.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	surE2	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid,F5_F8_type_C,FIVAR,Flg_new,Glyco_hydro_20,Glyco_hydro_20b,Mob_Pre
MMS1_k127_2252118_9	1178482.BJB45_04520	3.349e-55	198.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1XJUJ@135619|Oceanospirillales	135619|Oceanospirillales	O	Peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMS1_k127_2252118_4	1121085.AUCI01000005_gene959	4.647e-122	398.0	COG0667@1|root,COG0667@2|Bacteria,1TPIY@1239|Firmicutes,4HA4Q@91061|Bacilli,1ZCES@1386|Bacillus	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_2252118_16	639282.DEFDS_1397	5.677e-10	65.0	2ACFS@1|root,3121E@2|Bacteria,2GGNV@200930|Deferribacteres	200930|Deferribacteres	S	Domain of unknown function (DUF3783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3783
MMS1_k127_2252118_15	1120934.KB894409_gene6576	1.371e-26	116.0	COG0789@1|root,COG0789@2|Bacteria,2IFX0@201174|Actinobacteria,4E4TZ@85010|Pseudonocardiales	201174|Actinobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
MMS1_k127_2252118_7	1487921.DP68_02565	1.213e-99	334.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia,36UIW@31979|Clostridiaceae	186801|Clostridia	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_2252118_17	443144.GM21_2085	4.404e-06	50.0	2DGFU@1|root,2ZVU3@2|Bacteria,1P4ND@1224|Proteobacteria,433P8@68525|delta/epsilon subdivisions,2WY4U@28221|Deltaproteobacteria,43VV6@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2252864_2	632518.Calow_1944	1.98e-91	308.0	COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,24GF6@186801|Clostridia,42JBH@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2252864_1	632518.Calow_1943	3.243e-103	343.0	COG0395@1|root,COG0395@2|Bacteria,1UXK1@1239|Firmicutes,24XN6@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2252864_0	1047013.AQSP01000142_gene240	4.953e-185	591.0	COG3533@1|root,COG3533@2|Bacteria,2NNW0@2323|unclassified Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	F5_F8_type_C,Glyco_hydro_127
MMS1_k127_2256465_1	1123274.KB899424_gene3004	3.113e-14	79.0	COG0457@1|root,COG0457@2|Bacteria,2J7SI@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_7,TPR_8
MMS1_k127_2256465_0	1307761.L21SP2_1647	1.588e-50	200.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
MMS1_k127_2256982_2	545243.BAEV01000010_gene1107	1.1e-41	164.0	COG0142@1|root,COG0142@2|Bacteria,1TR0U@1239|Firmicutes,24AW3@186801|Clostridia,36DFW@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	hepT1	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS1_k127_2256982_1	1303518.CCALI_01625	1.71e-55	202.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	M1-798	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5,Rhodanese
MMS1_k127_2256982_0	118168.MC7420_1241	2.96e-80	278.0	COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H9WN@1150|Oscillatoriales	1117|Cyanobacteria	T	7TM diverse intracellular signalling	-	-	-	ko:K19694	-	-	-	-	ko00000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
MMS1_k127_2257477_2	1144275.COCOR_01696	9.187e-68	238.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2Z30B@29|Myxococcales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS1_k127_2257477_0	1444711.CCJF01000005_gene497	2.035e-120	405.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,2JGVC@204428|Chlamydiae	204428|Chlamydiae	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
MMS1_k127_2257477_1	880073.Calab_0385	2.064e-96	330.0	COG0642@1|root,COG2205@2|Bacteria,2NR04@2323|unclassified Bacteria	2|Bacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_2260244_0	744872.Spica_2556	2.904e-176	574.0	COG1413@1|root,COG2211@1|root,COG1413@2|Bacteria,COG2211@2|Bacteria,2J9QA@203691|Spirochaetes	203691|Spirochaetes	CG	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
MMS1_k127_2260244_1	665571.STHERM_c08610	2.956e-38	149.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
MMS1_k127_2260244_2	469617.FUAG_00027	1.179e-18	89.0	COG1959@1|root,COG1959@2|Bacteria,37A40@32066|Fusobacteria	32066|Fusobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS1_k127_2261213_0	589865.DaAHT2_1058	0.0	1068.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,42NYT@68525|delta/epsilon subdivisions,2WKSF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
MMS1_k127_2261213_1	1121403.AUCV01000002_gene593	2.999e-48	177.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,42SD7@68525|delta/epsilon subdivisions,2WPI5@28221|Deltaproteobacteria,2MIP3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
MMS1_k127_2262585_1	1536772.R70723_30965	1.088e-17	88.0	COG1846@1|root,COG1846@2|Bacteria,1V8EW@1239|Firmicutes,4HMWY@91061|Bacilli,26WXY@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
MMS1_k127_2262585_2	1392489.JPOL01000002_gene2786	2.562e-17	95.0	COG1538@1|root,COG1538@2|Bacteria,4NDZ6@976|Bacteroidetes,1HY4E@117743|Flavobacteriia,2XJP2@283735|Leeuwenhoekiella	976|Bacteroidetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS1_k127_2262585_0	1321778.HMPREF1982_02832	1.403e-192	613.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,267M1@186813|unclassified Clostridiales	186801|Clostridia	V	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2263894_0	1123274.KB899433_gene1333	2.881e-99	344.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_2263894_1	1307761.L21SP2_2621	5.108e-37	153.0	COG0210@1|root,COG0210@2|Bacteria,2J7FY@203691|Spirochaetes	203691|Spirochaetes	L	Participates in both transcription termination and antitermination	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C
MMS1_k127_2264191_0	771875.Ferpe_0822	3.268e-77	267.0	COG0111@1|root,COG0111@2|Bacteria,2GCKK@200918|Thermotogae	200918|Thermotogae	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_2264191_1	1129374.AJE_10909	1.628e-70	261.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,4664A@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
MMS1_k127_2264397_1	889378.Spiaf_1825	4.808e-139	453.0	COG0317@1|root,COG0317@2|Bacteria,2J5JE@203691|Spirochaetes	203691|Spirochaetes	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
MMS1_k127_2264397_6	665571.STHERM_c19290	3.219e-56	206.0	COG2890@1|root,COG2890@2|Bacteria,2J7VJ@203691|Spirochaetes	203691|Spirochaetes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMS1_k127_2264397_0	906968.Trebr_2115	5.503e-150	482.0	COG0216@1|root,COG0216@2|Bacteria,2J5KY@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
MMS1_k127_2264397_4	1123274.KB899427_gene3294	1.088e-58	210.0	COG0705@1|root,COG0705@2|Bacteria,2J7J3@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	ko:K02441	-	-	-	-	ko00000	-	-	-	Rhomboid
MMS1_k127_2264397_7	518766.Rmar_1355	2.303e-49	180.0	COG0394@1|root,COG0394@2|Bacteria,4NNQZ@976|Bacteroidetes,1FJBF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Low molecular weight phosphatase family	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
MMS1_k127_2264397_3	1410632.JHWW01000009_gene2521	1.383e-73	258.0	COG3001@1|root,COG3001@2|Bacteria,1U79A@1239|Firmicutes,248MR@186801|Clostridia,27IIA@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Fructosamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Fructosamin_kin
MMS1_k127_2264397_2	1105031.HMPREF1141_3197	7.84e-110	378.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,36FRE@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
MMS1_k127_2264397_5	1105031.HMPREF1141_3196	1.655e-58	222.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,36DSG@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_2267611_3	33035.JPJF01000032_gene2202	4.617e-20	98.0	COG0204@1|root,COG0204@2|Bacteria,1V9P5@1239|Firmicutes,24K2Z@186801|Clostridia	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
MMS1_k127_2267611_0	1499967.BAYZ01000136_gene20	4.201e-109	383.0	COG1033@1|root,COG1033@2|Bacteria,2NQ2I@2323|unclassified Bacteria	2|Bacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_2267611_2	1168034.FH5T_20985	1.992e-24	112.0	COG2430@1|root,COG2430@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF432
MMS1_k127_2267611_1	1168034.FH5T_20990	1.988e-73	256.0	COG0668@1|root,COG0668@2|Bacteria,4NEPW@976|Bacteroidetes,2G3EE@200643|Bacteroidia	2|Bacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
MMS1_k127_2268454_3	1480694.DC28_10860	1.715e-74	259.0	COG0037@1|root,COG0037@2|Bacteria,2J61I@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the TtcA family	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
MMS1_k127_2268454_7	768706.Desor_3522	3.232e-52	195.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia,264TH@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
MMS1_k127_2268454_2	573413.Spirs_2319	1.043e-75	261.0	COG1272@1|root,COG1272@2|Bacteria,2J5IS@203691|Spirochaetes	203691|Spirochaetes	S	channel protein, hemolysin III family	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
MMS1_k127_2268454_4	768706.Desor_0746	8.536e-67	234.0	COG0494@1|root,COG0494@2|Bacteria,1V6SF@1239|Firmicutes,24HCG@186801|Clostridia,261VE@186807|Peptococcaceae	186801|Clostridia	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_2268454_9	755178.Cyan10605_1644	4.531e-38	149.0	COG1943@1|root,COG1943@2|Bacteria,1G5Z6@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
MMS1_k127_2268454_5	221027.JO40_07500	2.333e-66	233.0	COG0846@1|root,COG0846@2|Bacteria,2J6BW@203691|Spirochaetes	203691|Spirochaetes	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
MMS1_k127_2268454_10	1283300.ATXB01000001_gene53	7.053e-32	134.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEM2@135618|Methylococcales	135618|Methylococcales	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg
MMS1_k127_2268454_1	158190.SpiGrapes_2045	8.807e-127	413.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_2268454_8	382464.ABSI01000011_gene2907	2.062e-48	182.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	pspA	GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141	-	ko:K03969	-	-	-	-	ko00000	-	-	-	LRAT,PspA_IM30
MMS1_k127_2268454_12	760011.Spico_0138	7.404e-16	82.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspB	-	-	ko:K03970,ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF4097,PspB,PspC
MMS1_k127_2268454_6	158189.SpiBuddy_2935	6.318e-57	206.0	COG1842@1|root,COG1842@2|Bacteria,2J5MH@203691|Spirochaetes	203691|Spirochaetes	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
MMS1_k127_2268454_11	760011.Spico_0138	3.876e-23	104.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspB	-	-	ko:K03970,ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF4097,PspB,PspC
MMS1_k127_2268454_0	1131462.DCF50_p701	1.397e-239	759.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,2618K@186807|Peptococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
MMS1_k127_2268454_13	1398491.P613_04860	3.192e-10	69.0	2ER2S@1|root,33IND@2|Bacteria,2J99N@203691|Spirochaetes	203691|Spirochaetes	S	Borrelia membrane protein P13	-	-	-	-	-	-	-	-	-	-	-	-	Borrelia_P13
MMS1_k127_2268454_14	316067.Geob_1811	1.371e-05	55.0	2F788@1|root,33ZPH@2|Bacteria,1NZCH@1224|Proteobacteria,430NT@68525|delta/epsilon subdivisions,2WVSK@28221|Deltaproteobacteria,43VB2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4410)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4410
MMS1_k127_2269676_1	1307761.L21SP2_2450	1.237e-147	476.0	COG0641@1|root,COG0641@2|Bacteria,2JB1P@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12
MMS1_k127_2269676_0	1307761.L21SP2_2449	1.311e-192	609.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS1_k127_2269676_2	1307761.L21SP2_2902	2.182e-36	142.0	COG0775@1|root,COG0775@2|Bacteria,2J6KX@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.30,3.2.2.9	ko:K01243,ko:K18284	ko00130,ko00270,ko01100,ko01110,ko01230,map00130,map00270,map01100,map01110,map01230	M00034,M00609	R00194,R01401,R10668	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS1_k127_2270514_3	1307761.L21SP2_3499	7.92e-05	51.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
MMS1_k127_2270514_2	906968.Trebr_2415	1.601e-22	100.0	COG0718@1|root,COG0718@2|Bacteria,2J90U@203691|Spirochaetes	203691|Spirochaetes	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
MMS1_k127_2270514_0	573413.Spirs_0086	1.541e-71	246.0	COG0353@1|root,COG0353@2|Bacteria,2J74I@203691|Spirochaetes	203691|Spirochaetes	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
MMS1_k127_2270514_1	1480694.DC28_08870	1.344e-57	202.0	COG3408@1|root,COG3408@2|Bacteria,2J5J1@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Trehalase	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
MMS1_k127_2271760_1	2423.NA23_0202445	2.725e-85	293.0	COG1653@1|root,COG1653@2|Bacteria,2GCBJ@200918|Thermotogae	200918|Thermotogae	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
MMS1_k127_2271760_0	660470.Theba_0946	1.507e-86	294.0	COG1175@1|root,COG1175@2|Bacteria,2GCBN@200918|Thermotogae	200918|Thermotogae	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
MMS1_k127_2271760_2	660470.Theba_0947	1.747e-79	279.0	COG0395@1|root,COG0395@2|Bacteria,2GCNX@200918|Thermotogae	200918|Thermotogae	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
MMS1_k127_2271760_3	1449063.JMLS01000004_gene2758	7.404e-45	173.0	2EPTA@1|root,33HDU@2|Bacteria,1UWBW@1239|Firmicutes,4I7NT@91061|Bacilli,26X43@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2275812_0	573413.Spirs_0492	3.505e-79	281.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_2275812_1	1469948.JPNB01000002_gene3442	3.183e-20	93.0	2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia,36MNV@31979|Clostridiaceae	186801|Clostridia	S	TSCPD domain	-	-	-	-	-	-	-	-	-	-	-	-	TSCPD
MMS1_k127_2275812_2	751945.Theos_0271	5.181e-15	85.0	COG1470@1|root,COG3895@1|root,COG1470@2|Bacteria,COG3895@2|Bacteria,1WIA5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384,PEGA
MMS1_k127_2277665_1	1123274.KB899427_gene3350	5.438e-09	59.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
MMS1_k127_2277665_0	1168289.AJKI01000040_gene3238	3.603e-156	509.0	COG3525@1|root,COG3537@1|root,COG3525@2|Bacteria,COG3537@2|Bacteria,4NE08@976|Bacteroidetes,2FNAR@200643|Bacteroidia,3XJV8@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolase family 20, domain 2	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX_C_1,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b,PA14
MMS1_k127_2277665_2	1280686.AUKE01000007_gene1780	0.0002094	51.0	COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24AFS@186801|Clostridia,4BYC6@830|Butyrivibrio	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
MMS1_k127_2281565_3	879212.DespoDRAFT_02676	1.151e-11	68.0	COG2849@1|root,COG2849@2|Bacteria,1RFCJ@1224|Proteobacteria,42RFQ@68525|delta/epsilon subdivisions,2WNEJ@28221|Deltaproteobacteria,2MN3V@213118|Desulfobacterales	28221|Deltaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2281565_2	573413.Spirs_4101	8.985e-85	290.0	COG1893@1|root,COG1893@2|Bacteria,2J93U@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
MMS1_k127_2281565_0	906968.Trebr_1915	2.953e-180	571.0	COG2152@1|root,COG2152@2|Bacteria,2J6XM@203691|Spirochaetes	203691|Spirochaetes	G	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose	-	-	2.4.1.281	ko:K16212	-	-	R09943	RC00049	ko00000,ko01000	-	-	-	Glyco_hydro_130
MMS1_k127_2281565_1	1168034.FH5T_02000	1.04e-85	297.0	COG2942@1|root,COG2942@2|Bacteria,4NEH7@976|Bacteroidetes,2FM9N@200643|Bacteroidia	976|Bacteroidetes	G	Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man)	bfce	-	5.1.3.11	ko:K16213	-	-	R01445,R10810	RC00289	ko00000,ko01000	-	-	-	GlcNAc_2-epim
MMS1_k127_2281785_0	1123274.KB899433_gene1351	9.576e-276	859.0	COG0441@1|root,COG0441@2|Bacteria,2J5ID@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
MMS1_k127_2282289_1	329726.AM1_1104	3.864e-19	101.0	COG0840@1|root,COG0840@2|Bacteria,1G245@1117|Cyanobacteria	1117|Cyanobacteria	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	GAF,HAMP,MCPsignal
MMS1_k127_2282289_0	1121396.KB892921_gene66	3.484e-69	252.0	COG2202@1|root,COG3275@1|root,COG4191@1|root,COG4936@1|root,COG2202@2|Bacteria,COG3275@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WKCD@28221|Deltaproteobacteria,2MPM3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,sCache_2
MMS1_k127_2282467_0	357809.Cphy_2042	9.386e-60	218.0	COG2378@1|root,COG2378@2|Bacteria,1V5QT@1239|Firmicutes,24EKM@186801|Clostridia	186801|Clostridia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
MMS1_k127_2282467_3	1034769.KB910518_gene5137	5.152e-14	77.0	COG0251@1|root,COG0251@2|Bacteria,1V76U@1239|Firmicutes,4HM2M@91061|Bacilli,26XV2@186822|Paenibacillaceae	91061|Bacilli	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
MMS1_k127_2282467_1	377629.TERTU_3762	1.049e-51	190.0	COG1280@1|root,COG1280@2|Bacteria,1RAI3@1224|Proteobacteria,1S2GP@1236|Gammaproteobacteria,2PPBR@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
MMS1_k127_2282467_2	573061.Clocel_2267	3.539e-27	113.0	COG1082@1|root,COG1082@2|Bacteria,1UIRS@1239|Firmicutes,25EQK@186801|Clostridia,36J8P@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2282467_4	195103.CPF_0983	6.291e-10	61.0	COG1082@1|root,COG1082@2|Bacteria,1UIRS@1239|Firmicutes,25EQK@186801|Clostridia,36J8P@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2286751_1	1045858.Bint_1486	3.752e-11	71.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	tar8	-	-	ko:K03406,ko:K03776	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HATPase_c,dCache_1
MMS1_k127_2286751_0	1089551.KE386572_gene3425	5.306e-21	96.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,4BSCN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	2'-5' RNA ligase superfamily	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS1_k127_228688_1	1265505.ATUG01000002_gene1043	2.73e-15	84.0	2C4IE@1|root,30ERP@2|Bacteria,1RG2Q@1224|Proteobacteria,42S4W@68525|delta/epsilon subdivisions,2WND7@28221|Deltaproteobacteria,2MN1X@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_228688_0	1232437.KL661988_gene228	8.647e-27	123.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42N3Y@68525|delta/epsilon subdivisions,2WJFS@28221|Deltaproteobacteria,2MJEA@213118|Desulfobacterales	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
MMS1_k127_2290848_2	1480694.DC28_12045	3.587e-12	68.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	rmaA	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_2290848_3	316274.Haur_2360	4.287e-08	59.0	2DN0I@1|root,32UR2@2|Bacteria,2G8Y2@200795|Chloroflexi,375Q5@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
MMS1_k127_2290848_0	1408473.JHXO01000001_gene1976	2.603e-60	222.0	COG0666@1|root,COG1835@1|root,COG0666@2|Bacteria,COG1835@2|Bacteria,4NIVR@976|Bacteroidetes,2FN9F@200643|Bacteroidia	976|Bacteroidetes	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
MMS1_k127_2290848_1	573413.Spirs_0075	1.634e-28	123.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	4.1.1.52	ko:K22213	-	-	-	-	ko00000,ko01000	-	-	-	Amidohydro_2
MMS1_k127_2296661_3	586413.CCDL010000001_gene508	3.17e-11	65.0	COG0477@1|root,COG2814@2|Bacteria,1UYJQ@1239|Firmicutes,4HCAW@91061|Bacilli,23NBC@182709|Oceanobacillus	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2296661_2	338963.Pcar_2569	2.55e-29	122.0	COG2984@1|root,COG2984@2|Bacteria,1R84M@1224|Proteobacteria,42PKD@68525|delta/epsilon subdivisions,2WMBV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
MMS1_k127_2296661_0	1121403.AUCV01000044_gene54	1.91e-33	135.0	COG2984@1|root,COG2984@2|Bacteria,1R84M@1224|Proteobacteria,42PKD@68525|delta/epsilon subdivisions,2WMBV@28221|Deltaproteobacteria,2MJYP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
MMS1_k127_2296661_1	1265505.ATUG01000001_gene4499	2.652e-33	139.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_2298831_0	748449.Halha_1924	1.399e-26	128.0	COG1305@1|root,COG1305@2|Bacteria,1VSWF@1239|Firmicutes,25AR7@186801|Clostridia,3WB60@53433|Halanaerobiales	186801|Clostridia	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
MMS1_k127_229886_1	744872.Spica_2854	2.849e-68	245.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
MMS1_k127_229886_0	744872.Spica_2854	6.603e-91	325.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
MMS1_k127_229886_3	744872.Spica_2853	7.258e-19	99.0	29XQJ@1|root,30JG9@2|Bacteria,2J89K@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_229886_2	935836.JAEL01000037_gene4277	7.529e-42	159.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,4HA0T@91061|Bacilli,1ZDJ1@1386|Bacillus	91061|Bacilli	S	COG0714 MoxR-like ATPases	yeaC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_2300292_4	1343739.PAP_07515	4.412e-08	64.0	arCOG09492@1|root,arCOG09492@2157|Archaea,2Y3AH@28890|Euryarchaeota,244X9@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2300292_2	208444.JNYY01000014_gene4323	6.482e-85	288.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4DZ0W@85010|Pseudonocardiales	201174|Actinobacteria	E	Branched-chain amino acid transport	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
MMS1_k127_2300292_1	1123274.KB899407_gene160	9.183e-115	374.0	COG0411@1|root,COG0411@2|Bacteria,2J67E@203691|Spirochaetes	203691|Spirochaetes	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
MMS1_k127_2300292_0	522772.Dacet_0894	5.222e-151	487.0	COG4177@1|root,COG4177@2|Bacteria,2GF8X@200930|Deferribacteres	200930|Deferribacteres	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
MMS1_k127_2300292_3	1123274.KB899407_gene162	1.032e-21	96.0	COG0559@1|root,COG0559@2|Bacteria,2J64W@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
MMS1_k127_2301085_3	158190.SpiGrapes_2090	1.457e-44	165.0	COG2208@1|root,COG2208@2|Bacteria,2J6CG@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
MMS1_k127_2301085_1	158190.SpiGrapes_2089	5.068e-142	469.0	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,2J73J@203691|Spirochaetes	203691|Spirochaetes	C	PAS PAC sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,PAS_8
MMS1_k127_2301085_4	158190.SpiGrapes_2088	5.147e-15	77.0	COG1905@1|root,COG1905@2|Bacteria,2J9FS@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
MMS1_k127_2301085_0	1480694.DC28_04965	0.0	1258.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2J5QM@203691|Spirochaetes	203691|Spirochaetes	C	alcohol dehydrogenase	-	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
MMS1_k127_2301085_2	158190.SpiGrapes_2087	7.745e-65	228.0	COG2344@1|root,COG2344@2|Bacteria,2J67B@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
MMS1_k127_2304331_3	1185653.A1A1_08134	0.0001808	48.0	COG3340@1|root,COG3340@2|Bacteria,1V6ZV@1239|Firmicutes,4HJCZ@91061|Bacilli,26FRK@186818|Planococcaceae	91061|Bacilli	E	Peptidase family S51	pepE	-	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
MMS1_k127_2304331_0	1232453.BAIF02000135_gene1598	7.686e-97	330.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
MMS1_k127_2304331_2	1144664.F973_01659	3.473e-23	100.0	COG1724@1|root,COG1724@2|Bacteria,1R11S@1224|Proteobacteria,1T4TC@1236|Gammaproteobacteria,3NPHU@468|Moraxellaceae	1236|Gammaproteobacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2304331_1	1094491.BBbe_08360	3.259e-26	111.0	COG4226@1|root,COG4226@2|Bacteria,1MZE7@1224|Proteobacteria,2V533@28211|Alphaproteobacteria,48U3X@772|Bartonellaceae	28211|Alphaproteobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
MMS1_k127_231_2	553973.CLOHYLEM_06239	4.116e-05	48.0	COG0438@1|root,COG0438@2|Bacteria,1V6F6@1239|Firmicutes,25BBF@186801|Clostridia	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_231_0	665571.STHERM_c15870	3.109e-98	332.0	COG1104@1|root,COG1104@2|Bacteria,2J5VR@203691|Spirochaetes	203691|Spirochaetes	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMS1_k127_231133_5	871968.DESME_04040	9.277e-05	45.0	COG0614@1|root,COG0614@2|Bacteria,1TQ11@1239|Firmicutes,2482R@186801|Clostridia	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS1_k127_231133_1	335541.Swol_2485	1.165e-57	210.0	COG1571@1|root,COG1571@2|Bacteria,1V2YE@1239|Firmicutes,24N2W@186801|Clostridia	186801|Clostridia	S	tRNA wobble cytosine modification	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_231133_0	767817.Desgi_0736	5.221e-79	273.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,2602Q@186807|Peptococcaceae	186801|Clostridia	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
MMS1_k127_231133_3	941449.dsx2_0696	2.439e-18	94.0	COG0619@1|root,COG0619@2|Bacteria,1RJIT@1224|Proteobacteria,42RU5@68525|delta/epsilon subdivisions,2WNB7@28221|Deltaproteobacteria,2MA26@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
MMS1_k127_231133_2	880073.Calab_3678	1.158e-41	160.0	COG0310@1|root,COG0310@2|Bacteria	2|Bacteria	P	cobalt ion transport	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
MMS1_k127_231133_4	767817.Desgi_0733	9.106e-05	46.0	COG5266@1|root,COG5266@2|Bacteria	2|Bacteria	P	PFAM Nickel transport complex, NikM subunit, transmembrane	-	-	-	ko:K16915	ko02010,map02010	M00246	-	-	ko00000,ko00001,ko00002,ko02000	-	-	-	DUF4198
MMS1_k127_2313344_0	1313421.JHBV01000035_gene2533	1.364e-62	228.0	COG1413@1|root,COG1413@2|Bacteria,4NG91@976|Bacteroidetes,1IVVN@117747|Sphingobacteriia	976|Bacteroidetes	C	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
MMS1_k127_2313344_1	485918.Cpin_4130	1.439e-19	93.0	2E02K@1|root,32VRJ@2|Bacteria,4NWXG@976|Bacteroidetes,1IYZ6@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2313846_6	523850.TON_0678	2.883e-08	59.0	COG0079@1|root,arCOG04273@2157|Archaea,2XV1E@28890|Euryarchaeota,243HB@183968|Thermococci	183968|Thermococci	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_2313846_4	1123274.KB899413_gene784	5.661e-42	160.0	COG2087@1|root,COG2087@2|Bacteria	2|Bacteria	H	cobinamide kinase activity	cobU	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568	2.7.1.156,2.7.7.62,6.3.5.10	ko:K02231,ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R05225,R06558	RC00002,RC00010,RC00428,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165	CobU
MMS1_k127_2313846_1	555079.Toce_0158	3.199e-98	332.0	COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia,42EKS@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
MMS1_k127_2313846_2	1123274.KB899413_gene785	2.27e-53	197.0	COG0368@1|root,COG0368@2|Bacteria,2J8ZE@203691|Spirochaetes	203691|Spirochaetes	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
MMS1_k127_2313846_5	580340.Tlie_0146	1.504e-27	119.0	COG0406@1|root,COG0406@2|Bacteria,3TAZ5@508458|Synergistetes	2|Bacteria	G	phosphoglycerate mutase family	gpmB	-	3.1.3.3,3.1.3.73,5.4.2.12	ko:K02226,ko:K15634,ko:K15640,ko:K22305	ko00010,ko00260,ko00680,ko00860,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00122	R00582,R01518,R04594,R11173	RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
MMS1_k127_2313846_3	1487921.DP68_09430	1.768e-45	166.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24J8R@186801|Clostridia,36JJG@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
MMS1_k127_2313846_0	331678.Cphamn1_1145	1.069e-121	404.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	int	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
MMS1_k127_2317395_4	690850.Desaf_0736	3.972e-14	74.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2M9N9@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	epsL	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
MMS1_k127_2317395_0	1396141.BATP01000036_gene3854	5.146e-129	420.0	COG0673@1|root,COG0673@2|Bacteria,46SAE@74201|Verrucomicrobia,2IU1W@203494|Verrucomicrobiae	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
MMS1_k127_2317395_2	1123248.KB893325_gene1213	2.164e-67	232.0	COG0110@1|root,COG0110@2|Bacteria,4NNPH@976|Bacteroidetes,1IX8P@117747|Sphingobacteriia	976|Bacteroidetes	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
MMS1_k127_2317395_1	404380.Gbem_1067	1.444e-125	411.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMS1_k127_2317395_3	906968.Trebr_0930	1.173e-54	204.0	COG1596@1|root,COG1596@2|Bacteria,2J6A1@203691|Spirochaetes	203691|Spirochaetes	M	export protein	-	-	-	-	-	-	-	-	-	-	-	-	SLBB
MMS1_k127_231778_1	754027.HMPREF9554_01435	6.022e-61	225.0	2CK99@1|root,3464J@2|Bacteria,2J60S@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_231778_0	573413.Spirs_2625	0.0	1136.0	COG0653@1|root,COG0653@2|Bacteria,2J5UR@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
MMS1_k127_231778_2	1121129.KB903371_gene257	2.867e-22	99.0	COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,2FME3@200643|Bacteroidia,22X07@171551|Porphyromonadaceae	976|Bacteroidetes	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS1_k127_231906_0	744872.Spica_1832	1.141e-128	421.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS1_k127_231906_1	665571.STHERM_c19490	3.539e-85	292.0	COG0341@1|root,COG0341@2|Bacteria,2J5N7@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS1_k127_231906_3	1111454.HMPREF1250_1377	0.0008722	51.0	COG0726@1|root,COG0726@2|Bacteria,1V62B@1239|Firmicutes,4H4CD@909932|Negativicutes	909932|Negativicutes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
MMS1_k127_231906_2	1123371.ATXH01000002_gene398	3.901e-32	130.0	COG0382@1|root,COG0761@1|root,COG0382@2|Bacteria,COG0761@2|Bacteria,2GH35@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
MMS1_k127_2319308_4	871963.Desdi_1436	0.0004736	42.0	COG2161@1|root,COG2161@2|Bacteria,1VA5D@1239|Firmicutes,24MBY@186801|Clostridia,262FI@186807|Peptococcaceae	186801|Clostridia	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
MMS1_k127_2319308_3	744872.Spica_1414	3.975e-45	170.0	COG0424@1|root,COG0424@2|Bacteria,2J7EA@203691|Spirochaetes	203691|Spirochaetes	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
MMS1_k127_2319308_0	906968.Trebr_1420	5.375e-133	428.0	COG0052@1|root,COG0052@2|Bacteria,2J5GZ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS1_k127_2319308_1	1123274.KB899412_gene1521	9.427e-95	317.0	COG0264@1|root,COG0264@2|Bacteria,2J58B@203691|Spirochaetes	203691|Spirochaetes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
MMS1_k127_2319308_2	1307761.L21SP2_1327	8.683e-69	239.0	COG0233@1|root,COG0233@2|Bacteria,2J6PZ@203691|Spirochaetes	203691|Spirochaetes	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
MMS1_k127_232320_3	545694.TREPR_1387	9.185e-25	113.0	2BS8T@1|root,32MAB@2|Bacteria,2J9GY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_232320_1	1123274.KB899436_gene1290	1.729e-55	198.0	COG2165@1|root,COG2165@2|Bacteria,2J7Y8@203691|Spirochaetes	203691|Spirochaetes	NU	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
MMS1_k127_232320_2	1123274.KB899436_gene1296	4.938e-46	179.0	2ANKW@1|root,31DK4@2|Bacteria,2JAP9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_232320_0	545695.TREAZ_2385	1.224e-57	209.0	2F1GG@1|root,33UH1@2|Bacteria,2J7U4@203691|Spirochaetes	203691|Spirochaetes	S	(Type IV) pilus assembly	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
MMS1_k127_2325599_4	1307761.L21SP2_2246	9.99e-27	115.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4242,Guanylate_cyc,HTH_18
MMS1_k127_2325599_5	1123009.AUID01000040_gene2313	2.986e-20	95.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2692N@186813|unclassified Clostridiales	186801|Clostridia	S	Thioesterase superfamily	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS1_k127_2325599_7	1504981.KO116_3033	1.653e-07	61.0	2DPXP@1|root,333U7@2|Bacteria,1N6PZ@1224|Proteobacteria,1SRDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2325599_0	1410653.JHVC01000002_gene4251	2.076e-259	811.0	COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,36DJY@31979|Clostridiaceae	186801|Clostridia	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
MMS1_k127_2325599_3	1304885.AUEY01000083_gene2533	1.486e-51	193.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,42STV@68525|delta/epsilon subdivisions,2WKKA@28221|Deltaproteobacteria,2MJB6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tellurite resistance protein TerB	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
MMS1_k127_2325599_1	632335.Calkr_0503	4.294e-82	283.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,42F4R@68295|Thermoanaerobacterales	186801|Clostridia	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
MMS1_k127_2325599_2	1408473.JHXO01000001_gene2133	1.441e-78	268.0	COG1853@1|root,COG1853@2|Bacteria,4NF4H@976|Bacteroidetes,2FMUN@200643|Bacteroidia	976|Bacteroidetes	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMS1_k127_2325599_6	1500281.JQKZ01000002_gene1572	3.181e-10	67.0	COG0500@1|root,COG2226@2|Bacteria,4NJTP@976|Bacteroidetes	976|Bacteroidetes	Q	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25,Methyltransf_31
MMS1_k127_233241_0	537013.CLOSTMETH_01912	9.402e-188	619.0	COG1538@1|root,COG3250@1|root,COG1538@2|Bacteria,COG3250@2|Bacteria,1V1D9@1239|Firmicutes,24H7I@186801|Clostridia	2|Bacteria	G	Psort location	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,FIVAR,Glyco_hydro_106,Glyco_hydro_2_N,OEP
MMS1_k127_233241_1	649639.Bcell_0289	3.552e-94	322.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,4HC8H@91061|Bacilli,1ZRCU@1386|Bacillus	91061|Bacilli	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_2334607_0	1480694.DC28_03525	3.908e-286	886.0	COG0459@1|root,COG0459@2|Bacteria,2J5CK@203691|Spirochaetes	203691|Spirochaetes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
MMS1_k127_2334607_2	573413.Spirs_3239	1.242e-18	88.0	28WXW@1|root,2ZIX0@2|Bacteria,2J96G@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2334607_1	573413.Spirs_3238	2.566e-25	109.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
MMS1_k127_2334607_3	889378.Spiaf_0202	6.154e-09	58.0	COG0342@1|root,COG0342@2|Bacteria,2J5UV@203691|Spirochaetes	203691|Spirochaetes	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS1_k127_2336452_0	1307761.L21SP2_1356	1.104e-160	512.0	COG0443@1|root,COG0443@2|Bacteria,2J5I0@203691|Spirochaetes	203691|Spirochaetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS1_k127_2336452_1	221027.JO40_02590	3.226e-132	431.0	COG0484@1|root,COG0484@2|Bacteria,2J614@203691|Spirochaetes	203691|Spirochaetes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMS1_k127_2336525_2	1027292.HMPREF9372_1236	1.946e-09	61.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,4HEK5@91061|Bacilli	91061|Bacilli	S	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_31
MMS1_k127_2336525_0	1121405.dsmv_3814	1.233e-225	711.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,42N5Y@68525|delta/epsilon subdivisions,2WJMT@28221|Deltaproteobacteria,2MMV2@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3169	PEPCK_ATP
MMS1_k127_2336525_1	1408287.AXUR01000021_gene373	7.308e-25	107.0	COG0583@1|root,COG0583@2|Bacteria,37A8K@32066|Fusobacteria	32066|Fusobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2337326_1	889378.Spiaf_0957	4.839e-06	50.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_2337326_0	889378.Spiaf_0956	2.591e-146	497.0	COG1033@1|root,COG1033@2|Bacteria	2|Bacteria	S	growth of symbiont in host cell	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_2338718_3	1307761.L21SP2_1940	1.053e-10	66.0	COG3209@1|root,COG3209@2|Bacteria,2J6SP@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
MMS1_k127_2338718_0	697303.Thewi_2109	4.997e-35	146.0	COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,42G1G@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
MMS1_k127_2338718_1	1089553.Tph_c14160	1.793e-24	113.0	COG2801@1|root,COG2801@2|Bacteria,1TQH6@1239|Firmicutes,249ZV@186801|Clostridia,42G1G@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,Mu-transpos_C,rve
MMS1_k127_2338718_2	1198232.CYCME_0548	9.14e-15	85.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,460IE@72273|Thiotrichales	72273|Thiotrichales	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
MMS1_k127_2339182_5	1121405.dsmv_2611	5.533e-11	75.0	COG0603@1|root,COG1402@1|root,COG0603@2|Bacteria,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2X9RQ@28221|Deltaproteobacteria,2MPA0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
MMS1_k127_2339182_3	1219084.AP014508_gene687	2.379e-56	210.0	COG1181@1|root,COG1181@2|Bacteria,2GBZA@200918|Thermotogae	200918|Thermotogae	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Methyltransf_25
MMS1_k127_2339182_2	1448860.BBJO01000014_gene1200	7.742e-63	239.0	COG1501@1|root,arCOG03663@2157|Archaea,2XV49@28890|Euryarchaeota,23V0G@183963|Halobacteria	183963|Halobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
MMS1_k127_2339182_0	247639.MGP2080_08836	1.289e-136	446.0	COG2020@1|root,COG2020@2|Bacteria,1NFH1@1224|Proteobacteria,1SDM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Ergosterol biosynthesis ERG4/ERG24 family	-	-	1.3.1.21,1.3.1.71	ko:K00213,ko:K00223	ko00100,ko01100,ko01110,ko01130,map00100,map01100,map01110,map01130	M00101,M00102	R01451,R01456,R05641,R07487,R07492	RC00138,RC00237	ko00000,ko00001,ko00002,ko01000	-	-	-	ERG4_ERG24
MMS1_k127_2339182_1	247639.MGP2080_08831	5.273e-68	241.0	COG0300@1|root,COG0300@2|Bacteria,1RBH6@1224|Proteobacteria,1S7XU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_2339182_4	563040.Saut_0397	9.117e-12	75.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42MS0@68525|delta/epsilon subdivisions,2YMTX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Diguanylate cyclase phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
MMS1_k127_2341343_0	1249627.D779_2678	4.067e-77	278.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RZ2Z@1236|Gammaproteobacteria,1X2BY@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS
MMS1_k127_2341343_1	1120953.AUBH01000002_gene1503	5.06e-09	63.0	2DE4K@1|root,32U2K@2|Bacteria,1MZYA@1224|Proteobacteria,1SBBH@1236|Gammaproteobacteria,46977@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2342120_0	158189.SpiBuddy_1517	1.922e-145	465.0	COG1175@1|root,COG1175@2|Bacteria,2J7PS@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2343261_1	1232410.KI421412_gene42	1.008e-28	127.0	COG0697@1|root,COG0697@2|Bacteria,1RE85@1224|Proteobacteria,42RRX@68525|delta/epsilon subdivisions,2WNMU@28221|Deltaproteobacteria,43ST0@69541|Desulfuromonadales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2343261_0	1120998.AUFC01000022_gene407	7.607e-45	167.0	COG1609@1|root,COG1609@2|Bacteria,1UW2T@1239|Firmicutes,25KQ0@186801|Clostridia,3WDPY@538999|Clostridiales incertae sedis	186801|Clostridia	K	Periplasmic binding protein-like domain	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	Peripla_BP_3
MMS1_k127_2344553_0	1156844.KB891811_gene4266	8.994e-108	357.0	COG3507@1|root,COG3507@2|Bacteria,2GNEY@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C,Glyco_hydr_30_2,Glyco_hydro_43,RicinB_lectin_2
MMS1_k127_2344553_1	1160721.RBI_II00456	1.469e-18	94.0	COG2207@1|root,COG2207@2|Bacteria,1V5PX@1239|Firmicutes,24INB@186801|Clostridia,3WHVW@541000|Ruminococcaceae	186801|Clostridia	K	transcriptional regulator AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
MMS1_k127_2344553_2	1045854.WKK_03590	5.684e-05	46.0	COG2249@1|root,COG2249@2|Bacteria,1VE0G@1239|Firmicutes,4HMHX@91061|Bacilli,4AY2H@81850|Leuconostocaceae	91061|Bacilli	C	NADPH-quinone reductase (modulator of drug activity B)	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
MMS1_k127_2344763_0	7213.XP_004528015.1	4.473e-09	72.0	2D8GD@1|root,2TA48@2759|Eukaryota,3AJS4@33154|Opisthokonta,3BZQQ@33208|Metazoa,3DGE8@33213|Bilateria,429IP@6656|Arthropoda,3SRMT@50557|Insecta	33208|Metazoa	S	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2
MMS1_k127_2344763_1	109760.SPPG_08219T0	1.685e-05	60.0	29BDQ@1|root,2RIGR@2759|Eukaryota,39XEG@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CD36,DUF642,TSP_1
MMS1_k127_2344763_3	1392498.JQLH01000001_gene1505	0.0001515	57.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,4PI47@976|Bacteroidetes,1IM97@117743|Flavobacteriia,2PI57@252356|Maribacter	976|Bacteroidetes	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,PKD
MMS1_k127_2344763_2	1123274.KB899436_gene1284	0.0001424	52.0	COG2911@1|root,COG3209@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K09800,ko:K11021,ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001,ko02000,ko02042	-	-	-	RHS_repeat
MMS1_k127_2345223_1	889378.Spiaf_0451	1.037e-59	218.0	COG4953@1|root,COG4953@2|Bacteria,2J606@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
MMS1_k127_2345223_0	1307761.L21SP2_1004	3.178e-145	486.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
MMS1_k127_2348006_0	1121396.KB893093_gene4426	5.459e-86	316.0	COG0642@1|root,COG0834@1|root,COG5002@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg,dCache_1
MMS1_k127_2358761_1	1304865.JAGF01000001_gene965	4.11e-22	99.0	2EG8Z@1|root,33A0S@2|Bacteria,2I8BH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2358761_0	889378.Spiaf_2336	8.712e-113	390.0	COG0210@1|root,COG0210@2|Bacteria,2J7FY@203691|Spirochaetes	203691|Spirochaetes	L	Participates in both transcription termination and antitermination	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,UvrD-helicase,UvrD_C
MMS1_k127_2359687_1	633149.Bresu_1756	1.167e-11	74.0	2E7B7@1|root,331UM@2|Bacteria,1NB58@1224|Proteobacteria,2UHAV@28211|Alphaproteobacteria,2KJYK@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2359687_0	1307761.L21SP2_1576	2.52e-131	428.0	COG1619@1|root,COG1619@2|Bacteria,2J6NW@203691|Spirochaetes	203691|Spirochaetes	V	LD-carboxypeptidase	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
MMS1_k127_2359861_1	350688.Clos_0883	5.058e-23	102.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36FU2@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_2359861_2	555779.Dthio_PD0436	1.096e-08	61.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,42Q61@68525|delta/epsilon subdivisions,2WM4W@28221|Deltaproteobacteria,2MG0J@213115|Desulfovibrionales	555779.Dthio_PD0436|-	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2359861_0	1304880.JAGB01000001_gene979	4.527e-75	263.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	ccpA	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_2363501_7	585394.RHOM_12265	1.447e-22	99.0	COG0079@1|root,COG1213@1|root,COG0079@2|Bacteria,COG1213@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,NTP_transf_3
MMS1_k127_2363501_9	452637.Oter_1832	5.591e-08	64.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
MMS1_k127_2363501_6	1499967.BAYZ01000033_gene1108	1.147e-32	130.0	COG3877@1|root,COG3877@2|Bacteria,2NRW8@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
MMS1_k127_2363501_8	1265505.ATUG01000001_gene4253	7.053e-18	95.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43DIC@68525|delta/epsilon subdivisions,2X8Q0@28221|Deltaproteobacteria,2MNS5@213118|Desulfobacterales	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,HATPase_c,HWE_HK,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
MMS1_k127_2363501_5	877455.Metbo_1144	1.955e-36	151.0	COG0784@1|root,arCOG06712@1|root,arCOG06537@2157|Archaea,arCOG06712@2157|Archaea,2XWYJ@28890|Euryarchaeota	28890|Euryarchaeota	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4,PAS_9,PadR,Response_reg
MMS1_k127_2363501_3	1173022.Cri9333_3812	6.241e-50	205.0	COG2203@1|root,COG3920@1|root,COG2203@2|Bacteria,COG3920@2|Bacteria,1GPXH@1117|Cyanobacteria,1HHTQ@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	ETR1	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_3,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9
MMS1_k127_2363501_2	1121918.ARWE01000001_gene2752	1.192e-91	337.0	COG0834@1|root,COG2202@1|root,COG4191@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_2363501_1	545696.HOLDEFILI_04150	4.109e-128	413.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,3VP6F@526524|Erysipelotrichia	526524|Erysipelotrichia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
MMS1_k127_2363501_0	469616.FMAG_01342	9.806e-141	452.0	COG3717@1|root,COG3717@2|Bacteria,379H6@32066|Fusobacteria	32066|Fusobacteria	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
MMS1_k127_2363501_4	1163671.JAGI01000002_gene1375	9.82e-46	173.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,36G86@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
MMS1_k127_2367668_2	243275.TDE_1929	1.915e-19	98.0	COG4942@1|root,COG4942@2|Bacteria,2J7HM@203691|Spirochaetes	203691|Spirochaetes	D	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS1_k127_2367668_1	744872.Spica_1043	1.557e-30	134.0	2C8R1@1|root,2ZG03@2|Bacteria,2J6QN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2367668_0	906968.Trebr_1664	3.745e-43	161.0	COG0295@1|root,COG0295@2|Bacteria,2J80W@203691|Spirochaetes	203691|Spirochaetes	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
MMS1_k127_2371117_0	1230342.CTM_23934	3.74e-69	242.0	COG0500@1|root,COG0500@2|Bacteria,1V1KE@1239|Firmicutes,24CG3@186801|Clostridia,36E66@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_2371117_1	189426.PODO_17060	1.104e-43	169.0	COG3393@1|root,COG3393@2|Bacteria,1UFJG@1239|Firmicutes,4HGNR@91061|Bacilli,26RE3@186822|Paenibacillaceae	91061|Bacilli	S	GNAT acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_10,Acetyltransf_9,GNAT_acetyltran
MMS1_k127_2372801_2	744872.Spica_1970	6.334e-60	213.0	COG0608@1|root,COG0608@2|Bacteria,2J5KW@203691|Spirochaetes	203691|Spirochaetes	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
MMS1_k127_2372801_1	744872.Spica_1971	7.679e-159	511.0	COG0213@1|root,COG0213@2|Bacteria,2J607@203691|Spirochaetes	203691|Spirochaetes	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
MMS1_k127_2372801_3	889378.Spiaf_1440	1.625e-17	93.0	COG1381@1|root,COG1381@2|Bacteria	2|Bacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
MMS1_k127_2372801_0	1123274.KB899430_gene1685	5.303e-293	912.0	COG0466@1|root,COG0466@2|Bacteria,2J5CV@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS1_k127_2375739_0	694427.Palpr_0623	5.866e-76	259.0	COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,2FR3B@200643|Bacteroidia	976|Bacteroidetes	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Glyco_hydro_127,Thioredox_DsbH
MMS1_k127_2375739_1	59374.Fisuc_0026	6.85e-43	173.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS1_k127_2384865_0	1410668.JNKC01000001_gene1766	1.956e-63	222.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24CFW@186801|Clostridia,36VPS@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS1_k127_2384865_2	1304885.AUEY01000007_gene1334	1.921e-49	187.0	COG0716@1|root,COG1149@1|root,COG0716@2|Bacteria,COG1149@2|Bacteria,1NFA5@1224|Proteobacteria,42WN8@68525|delta/epsilon subdivisions,2WRNS@28221|Deltaproteobacteria,2MNUP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Flavodoxin_5
MMS1_k127_2384865_1	1537917.JU82_04265	2.301e-62	222.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QAG@68525|delta/epsilon subdivisions,2YNQV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
MMS1_k127_2385224_3	926550.CLDAP_05920	1.206e-05	47.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
MMS1_k127_2385224_2	926550.CLDAP_05930	6.401e-76	261.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,cNMP_binding
MMS1_k127_2385224_0	926550.CLDAP_06400	9.709e-238	754.0	COG3383@1|root,COG3383@2|Bacteria,2GBH3@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS1_k127_2385224_1	1189620.AJXL01000130_gene1665	1.569e-128	425.0	COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1HWWU@117743|Flavobacteriia,2NTA6@237|Flavobacterium	976|Bacteroidetes	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Glyco_hydro_127,Thioredox_DsbH
MMS1_k127_2385611_1	1123274.KB899408_gene3855	1.491e-14	79.0	COG2940@1|root,COG2940@2|Bacteria	2|Bacteria	K	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
MMS1_k127_2385611_0	573413.Spirs_2346	2.045e-46	192.0	COG0457@1|root,COG1474@1|root,COG0457@2|Bacteria,COG1474@2|Bacteria,2J6N3@203691|Spirochaetes	203691|Spirochaetes	LO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2386591_0	1274374.CBLK010000055_gene95	5.976e-130	421.0	COG3458@1|root,COG3458@2|Bacteria,1TS02@1239|Firmicutes,4HD4X@91061|Bacilli,276XC@186822|Paenibacillaceae	91061|Bacilli	Q	Acetyl xylan esterase (AXE1)	axe1	-	3.1.1.41	ko:K01060	ko00311,ko01130,map00311,map01130	-	R03062	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	AXE1
MMS1_k127_2386591_4	338963.Pcar_2615	1.373e-08	65.0	COG4286@1|root,COG4286@2|Bacteria,1N2H3@1224|Proteobacteria,42U4B@68525|delta/epsilon subdivisions,2WQEU@28221|Deltaproteobacteria,43T4S@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0160)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0160
MMS1_k127_2386591_2	1158602.I590_01636	7.618e-30	122.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,4HJMF@91061|Bacilli,4B344@81852|Enterococcaceae	91061|Bacilli	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
MMS1_k127_2386591_1	744872.Spica_0048	4.002e-42	170.0	COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,2J6XS@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,sCache_2
MMS1_k127_2388380_1	1480694.DC28_09335	6.938e-19	87.0	COG0583@1|root,COG0583@2|Bacteria,2JAVK@203691|Spirochaetes	203691|Spirochaetes	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2388380_0	545693.BMQ_2707	6.46e-52	200.0	COG2084@1|root,COG2084@2|Bacteria,1VS8P@1239|Firmicutes,4HTTT@91061|Bacilli,1ZFJJ@1386|Bacillus	91061|Bacilli	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	yfjR	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
MMS1_k127_2388380_2	96561.Dole_1325	4.462e-09	68.0	2AJQY@1|root,31ACW@2|Bacteria,1Q5CW@1224|Proteobacteria,4311R@68525|delta/epsilon subdivisions,2WWI4@28221|Deltaproteobacteria,2MP0K@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2390749_1	526222.Desal_1546	3.633e-23	99.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42PEN@68525|delta/epsilon subdivisions,2WJ9F@28221|Deltaproteobacteria,2M9B5@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
MMS1_k127_2390749_0	1121405.dsmv_0754	8.148e-111	362.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NUE@68525|delta/epsilon subdivisions,2WJYH@28221|Deltaproteobacteria,2MI0A@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
MMS1_k127_2393145_0	1121396.KB893066_gene1590	4.283e-104	341.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria,2MQ1R@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
MMS1_k127_2393145_2	573413.Spirs_1950	5.459e-26	124.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHB_HEX_C_1,CHU_C,Calx-beta,DUF4082,Flg_new,LRR_5,SLH
MMS1_k127_2393145_1	585394.RHOM_02165	1.305e-98	346.0	COG5164@1|root,COG5434@1|root,COG5164@2|Bacteria,COG5434@2|Bacteria,1TSA5@1239|Firmicutes,24B0W@186801|Clostridia	186801|Clostridia	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2396364_1	1317118.ATO8_08326	5.947e-49	193.0	COG2244@1|root,COG2244@2|Bacteria,1PHY1@1224|Proteobacteria,2UQ94@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2396364_0	1026882.MAMP_00840	1.365e-89	310.0	COG0438@1|root,COG0438@2|Bacteria,1P8MT@1224|Proteobacteria,1S8IY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS1_k127_2403339_2	298654.FraEuI1c_4073	1.745e-26	114.0	COG1028@1|root,COG1028@2|Bacteria,2GM3R@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
MMS1_k127_2403339_3	1123321.KB905821_gene4159	2.556e-17	93.0	COG1522@1|root,COG1522@2|Bacteria,2GKP4@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS1_k127_2403339_1	1122621.ATZA01000023_gene4222	1.096e-74	265.0	2C6HI@1|root,2Z8N7@2|Bacteria	1122621.ATZA01000023_gene4222|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2403339_0	877415.JNJQ01000005_gene1285	3.299e-82	280.0	COG1028@1|root,COG1028@2|Bacteria,1TRYD@1239|Firmicutes,3VQ2H@526524|Erysipelotrichia	526524|Erysipelotrichia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS1_k127_2403339_6	1122970.AUHC01000001_gene886	0.0001392	50.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria,2K46C@204457|Sphingomonadales	204457|Sphingomonadales	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
MMS1_k127_2403339_4	1408304.JAHA01000004_gene980	1.055e-12	69.0	COG2207@1|root,COG2207@2|Bacteria,1TR15@1239|Firmicutes,24BPT@186801|Clostridia,4BXW1@830|Butyrivibrio	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_2408477_3	1048983.EL17_14150	1.539e-26	113.0	COG4636@1|root,COG4636@2|Bacteria,4NNM9@976|Bacteroidetes,47Q0X@768503|Cytophagia	976|Bacteroidetes	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
MMS1_k127_2408477_1	227086.JGI_V11_47453	1.034e-58	219.0	COG1577@1|root,KOG1511@2759|Eukaryota	2759|Eukaryota	I	mevalonate kinase activity	mvk-1	GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006066,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006694,GO:0006695,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016126,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653	2.7.1.36,5.4.2.12	ko:K00869,ko:K15633	ko00010,ko00260,ko00680,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04146,map00010,map00260,map00680,map00900,map01100,map01110,map01120,map01130,map01200,map01230,map04146	M00001,M00002,M00003,M00095	R01518,R02245	RC00002,RC00017,RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS1_k127_2408477_0	224325.AF_0075	2.016e-73	262.0	COG0608@1|root,arCOG00427@2157|Archaea,2Y2ZU@28890|Euryarchaeota,246X7@183980|Archaeoglobi	183980|Archaeoglobi	L	phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2408477_2	1499967.BAYZ01000038_gene2275	2.537e-56	207.0	COG1349@1|root,COG1349@2|Bacteria,2NPT7@2323|unclassified Bacteria	2|Bacteria	K	DeoR C terminal sensor domain	repA	-	-	ko:K02081,ko:K02444,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
MMS1_k127_2408477_4	443254.Marpi_1107	4.45e-20	93.0	COG1653@1|root,COG1653@2|Bacteria,2GCBJ@200918|Thermotogae	200918|Thermotogae	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
MMS1_k127_2416305_7	1125699.HMPREF9194_01866	5.078e-12	72.0	COG0457@1|root,COG0457@2|Bacteria,2J780@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
MMS1_k127_2416305_5	1232453.BAIF02000087_gene287	1.51e-45	172.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,26968@186813|unclassified Clostridiales	186801|Clostridia	H	Probable molybdopterin binding domain	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
MMS1_k127_2416305_4	1131462.DCF50_p1642	1.547e-50	185.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,261ZC@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
MMS1_k127_2416305_2	742818.HMPREF9451_01438	6.105e-92	314.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4CUGB@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
MMS1_k127_2416305_1	572544.Ilyop_1427	6.1e-165	530.0	COG2211@1|root,COG2211@2|Bacteria,3783P@32066|Fusobacteria	32066|Fusobacteria	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
MMS1_k127_2416305_0	573413.Spirs_2249	3.49e-177	574.0	COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
MMS1_k127_2416305_3	665571.STHERM_c20410	1.297e-74	262.0	COG1638@1|root,COG1638@2|Bacteria,2J5PX@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
MMS1_k127_2416305_6	1307761.L21SP2_1275	1.476e-13	73.0	COG5660@1|root,2Z7TM@2|Bacteria,2JBFN@203691|Spirochaetes	203691|Spirochaetes	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
MMS1_k127_2418223_0	573413.Spirs_1518	3.63e-42	166.0	2DRY6@1|root,33DN5@2|Bacteria,2JB74@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2418223_1	545695.TREAZ_1177	5.275e-19	96.0	2F5EV@1|root,33Y0K@2|Bacteria,2J7SP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2424114_5	642492.Clole_2843	1.374e-12	74.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
MMS1_k127_2424114_0	665571.STHERM_c06850	2.368e-137	445.0	COG0722@1|root,COG0722@2|Bacteria,2J6I9@203691|Spirochaetes	203691|Spirochaetes	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS1_k127_2424114_2	573413.Spirs_0240	1.666e-75	272.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SLT
MMS1_k127_2424114_3	929556.Solca_2612	5.206e-47	175.0	COG0727@1|root,COG0727@2|Bacteria,4NJH9@976|Bacteroidetes,1ITJ5@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
MMS1_k127_2424114_4	439235.Dalk_3405	3.176e-42	156.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2WP2B@28221|Deltaproteobacteria,2MK4J@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897	PRA-CH,PRA-PH
MMS1_k127_2424114_1	1123274.KB899412_gene1505	2.635e-98	329.0	COG4284@1|root,COG4284@2|Bacteria,2J6J4@203691|Spirochaetes	203691|Spirochaetes	G	UTP--glucose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UDPGP
MMS1_k127_2429396_1	903818.KI912268_gene2895	1.243e-162	552.0	2F5K5@1|root,33Y5A@2|Bacteria	903818.KI912268_gene2895|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2429396_0	1391647.AVSV01000013_gene2762	7.263e-171	544.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	thlA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_2429396_3	903818.KI912268_gene3342	3.416e-77	269.0	COG1788@1|root,COG1788@2|Bacteria	2|Bacteria	I	CoA-transferase activity	atoD	-	2.8.3.8,2.8.3.9	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
MMS1_k127_2429396_2	903818.KI912268_gene3343	6.26e-89	299.0	COG2057@1|root,COG2057@2|Bacteria,3Y3EC@57723|Acidobacteria	57723|Acidobacteria	I	Coenzyme A transferase	-	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
MMS1_k127_2430716_8	1123274.KB899415_gene2522	1.155e-47	173.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
MMS1_k127_2430716_5	1123274.KB899415_gene2521	5.558e-81	274.0	COG4660@1|root,COG4660@2|Bacteria,2J58U@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rsxE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
MMS1_k127_2430716_9	1123274.KB899415_gene2520	1.535e-36	146.0	COG4659@1|root,COG4659@2|Bacteria	2|Bacteria	C	FMN binding	rnfG	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009279,GO:0016020,GO:0016491,GO:0016651,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0055114,GO:0071944	-	ko:K03612,ko:K03613,ko:K21559	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind
MMS1_k127_2430716_2	573413.Spirs_1910	1.969e-127	415.0	COG4658@1|root,COG4658@2|Bacteria,2J639@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
MMS1_k127_2430716_1	1123274.KB899415_gene2518	1.857e-159	514.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
MMS1_k127_2430716_6	545695.TREAZ_0286	3.613e-64	231.0	COG0564@1|root,COG0564@2|Bacteria,2J7HP@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the pseudouridine synthase RluA family	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
MMS1_k127_2430716_3	1121403.AUCV01000050_gene2095	9.018e-102	340.0	COG1302@1|root,COG1302@2|Bacteria	2|Bacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
MMS1_k127_2430716_7	1307761.L21SP2_0814	1.832e-56	211.0	COG0457@1|root,COG0457@2|Bacteria,2J6MJ@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF1570
MMS1_k127_2430716_4	1307761.L21SP2_0813	8.66e-91	312.0	COG0617@1|root,COG0617@2|Bacteria,2J5VH@203691|Spirochaetes	203691|Spirochaetes	H	Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
MMS1_k127_2430716_0	1480694.DC28_14775	2.86e-169	541.0	COG0124@1|root,COG0124@2|Bacteria,2J5DX@203691|Spirochaetes	203691|Spirochaetes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMS1_k127_2432234_2	401526.TcarDRAFT_1150	5.08e-100	328.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4H2F6@909932|Negativicutes	909932|Negativicutes	E	PFAM Peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
MMS1_k127_2432234_1	1304885.AUEY01000002_gene321	5.988e-125	406.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,2MI3X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
MMS1_k127_2432234_0	203122.Sde_1318	3.336e-311	960.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,465S2@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Cellobiose phosphorylase	ndvB	-	2.4.1.20,2.4.1.321	ko:K00702,ko:K13688,ko:K18786	ko00500,ko01100,map00500,map01100	-	R00952,R10832	RC00049,RC00397	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
MMS1_k127_2436186_4	665571.STHERM_c11560	5.123e-57	201.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
MMS1_k127_2436186_5	463191.SSEG_08034	1.902e-51	188.0	COG1309@1|root,COG1309@2|Bacteria,2HX7D@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_C_6,TetR_N
MMS1_k127_2436186_0	640513.Entas_2488	4.669e-136	440.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,3X374@547|Enterobacter	1236|Gammaproteobacteria	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
MMS1_k127_2436186_1	439235.Dalk_2032	1.653e-99	337.0	COG2267@1|root,COG2267@2|Bacteria,1QYAK@1224|Proteobacteria,43ECK@68525|delta/epsilon subdivisions,2WVYY@28221|Deltaproteobacteria,2MPDV@213118|Desulfobacterales	1224|Proteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
MMS1_k127_2436186_2	1449126.JQKL01000008_gene229	3.862e-82	282.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1V06C@1239|Firmicutes,24GWM@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2436186_10	1507.HMPREF0262_02168	1.185e-15	83.0	COG1846@1|root,COG1846@2|Bacteria,1V56Y@1239|Firmicutes,24CBI@186801|Clostridia,36N27@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS1_k127_2436186_3	1123008.KB905694_gene1591	1.681e-64	227.0	COG2077@1|root,COG2077@2|Bacteria,4NNGR@976|Bacteroidetes,2FSI3@200643|Bacteroidia,22XVV@171551|Porphyromonadaceae	976|Bacteroidetes	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
MMS1_k127_2436186_7	1086011.HJ01_01377	8.504e-27	114.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia,2NWVD@237|Flavobacterium	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
MMS1_k127_2436186_9	525897.Dbac_2126	4.939e-16	88.0	COG0834@1|root,COG0834@2|Bacteria,1PC78@1224|Proteobacteria,437TK@68525|delta/epsilon subdivisions,2X32W@28221|Deltaproteobacteria,2MDF6@213115|Desulfovibrionales	28221|Deltaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_2436186_8	335543.Sfum_2905	3.06e-20	96.0	2E69N@1|root,32VUZ@2|Bacteria,1N7CR@1224|Proteobacteria,42VYJ@68525|delta/epsilon subdivisions,2WRCJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2437072_0	1231241.Mc24_00759	2.548e-139	455.0	COG1653@1|root,COG1653@2|Bacteria,2GDD7@200918|Thermotogae	200918|Thermotogae	G	extracellular solute-binding protein, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_2437072_1	717606.PaecuDRAFT_2301	1.646e-38	155.0	COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,4HE9A@91061|Bacilli,26TMS@186822|Paenibacillaceae	91061|Bacilli	K	LacI family transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_2442031_0	1304284.L21TH_0417	5.319e-116	387.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_2442031_1	400668.Mmwyl1_1400	3.681e-08	56.0	COG2161@1|root,COG2161@2|Bacteria,1N8QY@1224|Proteobacteria,1SFWC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
MMS1_k127_2443773_0	1121459.AQXE01000008_gene885	1.483e-109	370.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M7RA@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_2443773_1	158190.SpiGrapes_2592	1.878e-103	339.0	COG1028@1|root,COG1028@2|Bacteria,2J6IK@203691|Spirochaetes	203691|Spirochaetes	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
MMS1_k127_2449663_0	573413.Spirs_0240	8.918e-51	188.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SLT
MMS1_k127_2449663_1	573413.Spirs_0339	2.274e-42	160.0	COG0477@1|root,COG2814@2|Bacteria,2JA5Q@203691|Spirochaetes	203691|Spirochaetes	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
MMS1_k127_2449663_2	1321778.HMPREF1982_01729	3.259e-05	46.0	COG0477@1|root,COG2814@2|Bacteria,1TQDU@1239|Firmicutes,25ESY@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2454845_0	1121289.JHVL01000005_gene1036	2.602e-170	540.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia,36FWB@31979|Clostridiaceae	186801|Clostridia	S	Dihydrodipicolinate reductase, N-terminus	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
MMS1_k127_2455504_4	1120970.AUBZ01000012_gene1967	6.369e-42	158.0	COG3007@1|root,COG3007@2|Bacteria,1MWCQ@1224|Proteobacteria,1RPPP@1236|Gammaproteobacteria,4657U@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)	fabV	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050343,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
MMS1_k127_2455504_3	889378.Spiaf_2215	6.256e-61	214.0	COG0764@1|root,COG0764@2|Bacteria,2J7PK@203691|Spirochaetes	203691|Spirochaetes	I	dehydratase	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
MMS1_k127_2455504_0	635013.TherJR_2071	1.596e-152	492.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_2455504_2	889378.Spiaf_0248	5.835e-74	256.0	COG1028@1|root,COG1028@2|Bacteria,2J6CJ@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_2455504_1	665571.STHERM_c00840	1.912e-103	345.0	COG0332@1|root,COG0332@2|Bacteria,2J6DC@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
MMS1_k127_2455504_5	572544.Ilyop_0636	5.674e-05	51.0	COG0746@1|root,COG0746@2|Bacteria,37AYE@32066|Fusobacteria	32066|Fusobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
MMS1_k127_2456067_4	466088.CL42_12145	3.167e-19	92.0	COG1011@1|root,COG1011@2|Bacteria,1MVF8@1224|Proteobacteria,1T28K@1236|Gammaproteobacteria,3NMDW@468|Moraxellaceae	1236|Gammaproteobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS1_k127_2456067_2	768706.Desor_2155	7.935e-51	192.0	COG1595@1|root,COG1595@2|Bacteria,1TSCX@1239|Firmicutes,24CVD@186801|Clostridia,264W3@186807|Peptococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
MMS1_k127_2456067_6	1322246.BN4_20513	2.801e-09	62.0	2AHVV@1|root,3188M@2|Bacteria,1PZZ2@1224|Proteobacteria,4369I@68525|delta/epsilon subdivisions,2X9GY@28221|Deltaproteobacteria,2MDEU@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2456067_3	1232410.KI421428_gene1020	2.899e-30	129.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,42RAQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	HAD-superfamily hydrolase, subfamily IIA	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
MMS1_k127_2456067_0	1122917.KB899666_gene3405	4.433e-65	235.0	COG0412@1|root,COG0412@2|Bacteria,1TQQS@1239|Firmicutes,4HGK4@91061|Bacilli,26SWC@186822|Paenibacillaceae	1239|Firmicutes	Q	Abhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_7,BAAT_C
MMS1_k127_2456067_1	484770.UFO1_3957	8.775e-54	196.0	COG1670@1|root,COG1670@2|Bacteria,1UVS3@1239|Firmicutes,4H647@909932|Negativicutes	909932|Negativicutes	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
MMS1_k127_2456067_5	768704.Desmer_4369	1.174e-18	93.0	COG2208@1|root,COG4191@1|root,COG2208@2|Bacteria,COG4191@2|Bacteria,1TWCW@1239|Firmicutes,25A37@186801|Clostridia,26428@186807|Peptococcaceae	186801|Clostridia	KT	stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
MMS1_k127_2456426_2	1121403.AUCV01000084_gene3377	4.215e-12	73.0	COG1305@1|root,COG1305@2|Bacteria,1Q712@1224|Proteobacteria,433SV@68525|delta/epsilon subdivisions,2WYAY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
MMS1_k127_2456426_1	573413.Spirs_0331	5.148e-140	458.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
MMS1_k127_2456426_0	322710.Avin_28310	0.0	1083.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,1RPG4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Isocitrate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
MMS1_k127_2456495_3	1168034.FH5T_05340	1.427e-79	274.0	COG1284@1|root,COG1284@2|Bacteria,4NG9F@976|Bacteroidetes,2FP2N@200643|Bacteroidia	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
MMS1_k127_2456495_1	862515.HMPREF0658_1901	1.255e-120	392.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS1_k127_2456495_4	1499967.BAYZ01000073_gene2019	1.122e-74	262.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_2456495_5	211165.AJLN01000100_gene4106	8.917e-44	166.0	COG0500@1|root,COG2226@2|Bacteria,1G79M@1117|Cyanobacteria,1JM23@1189|Stigonemataceae	1117|Cyanobacteria	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS1_k127_2456495_7	269799.Gmet_1931	4.554e-30	125.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS1_k127_2456495_0	498761.HM1_1803	3.424e-151	490.0	COG1271@1|root,COG1271@2|Bacteria,1TRH4@1239|Firmicutes,24D51@186801|Clostridia	186801|Clostridia	C	oxidase, subunit	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
MMS1_k127_2456495_2	635013.TherJR_0853	9.782e-97	326.0	COG1294@1|root,COG1294@2|Bacteria,1TRYV@1239|Firmicutes,24CPA@186801|Clostridia,261EQ@186807|Peptococcaceae	186801|Clostridia	C	oxidase, subunit II	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
MMS1_k127_2456495_6	316274.Haur_2448	3.763e-36	141.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
MMS1_k127_2456926_2	1265505.ATUG01000001_gene4498	1.986e-48	178.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42S9W@68525|delta/epsilon subdivisions,2WNX4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8
MMS1_k127_2456926_0	1321778.HMPREF1982_01145	2.679e-130	432.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,268HT@186813|unclassified Clostridiales	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS1_k127_2456926_1	1304284.L21TH_0721	1.369e-66	243.0	COG0312@1|root,COG0312@2|Bacteria,1V3G5@1239|Firmicutes,249ZM@186801|Clostridia,36DH9@31979|Clostridiaceae	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS1_k127_2459291_3	84531.JMTZ01000168_gene725	3.801e-08	58.0	290G0@1|root,2ZN55@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2459291_0	573413.Spirs_4144	8.953e-190	604.0	COG1785@1|root,COG1785@2|Bacteria,2J67K@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the alkaline phosphatase family	phoB	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
MMS1_k127_2459291_1	584708.Apau_1730	1.011e-126	416.0	COG5438@1|root,COG5438@2|Bacteria,3TA8P@508458|Synergistetes	508458|Synergistetes	S	PFAM YibE F family protein	-	-	-	-	-	-	-	-	-	-	-	-	YibE_F
MMS1_k127_2459291_2	1211817.CCAT010000045_gene2975	2.374e-51	187.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,36FWR@31979|Clostridiaceae	186801|Clostridia	I	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
MMS1_k127_2461130_1	1117315.AHCA01000001_gene1922	3.494e-05	56.0	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,2PZUK@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	G	COG3325 Chitinase	chiA	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	CBM_5_12,ChitinaseA_N,Glyco_hydro_18,REJ
MMS1_k127_2461130_0	484770.UFO1_0686	5.364e-16	80.0	COG0655@1|root,COG0655@2|Bacteria,1VCYD@1239|Firmicutes	1239|Firmicutes	S	Nadph-dependent fmn reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_2461448_5	414684.RC1_0158	4.913e-39	159.0	COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,2TU95@28211|Alphaproteobacteria,2JY85@204441|Rhodospirillales	204441|Rhodospirillales	NU	Outer membrane usher protein	-	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	Usher
MMS1_k127_2461448_2	1480694.DC28_13540	2.395e-45	173.0	COG3121@1|root,COG3121@2|Bacteria,2JATE@203691|Spirochaetes	203691|Spirochaetes	NU	Pili and flagellar-assembly chaperone, PapD N-terminal domain	-	-	-	ko:K07346	-	-	-	-	ko00000,ko02035,ko02044,ko03110	-	-	-	PapD_N
MMS1_k127_2461448_6	1480694.DC28_13545	2.676e-36	143.0	2EPCM@1|root,33GZA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2461448_0	880073.Calab_2933	2.084e-143	468.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_2461448_1	596152.DesU5LDRAFT_1906	1.427e-117	391.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NJ4@68525|delta/epsilon subdivisions,2WJXN@28221|Deltaproteobacteria,2M84T@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM UMUC domain protein DNA-repair protein	umuC	-	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4113,IMS,IMS_C,IMS_HHH
MMS1_k127_2461448_4	748280.NH8B_1668	6.44e-43	160.0	COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,2VU86@28216|Betaproteobacteria,2KS0A@206351|Neisseriales	206351|Neisseriales	L	Belongs to the peptidase S24 family	-	-	-	ko:K03503	-	-	-	-	ko00000,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
MMS1_k127_2461448_3	56780.SYN_03005	3.19e-44	166.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,42R47@68525|delta/epsilon subdivisions,2WNUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Membrane protein, UPF0126 and UPF0126 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
MMS1_k127_2462669_1	318167.Sfri_0340	2.427e-73	254.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,2QAPB@267890|Shewanellaceae	1236|Gammaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabF2	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_2462669_2	59374.Fisuc_3001	2.603e-24	109.0	COG4706@1|root,COG4706@2|Bacteria	2|Bacteria	I	dehydratase	fabZ2	-	-	-	-	-	-	-	-	-	-	-	FabA
MMS1_k127_2462669_0	94122.Shewana3_0326	2.354e-166	532.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RQH7@1236|Gammaproteobacteria,2Q9QY@267890|Shewanellaceae	1236|Gammaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabF1	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_2462669_3	553207.HMPREF0299_5538	9.244e-05	52.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,22JV7@1653|Corynebacteriaceae	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
MMS1_k127_2466539_3	649747.HMPREF0083_05285	4.96e-22	104.0	COG2217@1|root,COG2217@2|Bacteria,1VJJE@1239|Firmicutes,4HM5J@91061|Bacilli	91061|Bacilli	P	Heavy metal translocating P-type atpase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2466539_0	1132441.KI519454_gene113	1.176e-101	347.0	COG0842@1|root,COG0842@2|Bacteria,2GMXR@201174|Actinobacteria,1W8DM@1268|Micrococcaceae	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
MMS1_k127_2466539_1	1312954.KI914863_gene2330	1.281e-76	268.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
MMS1_k127_2466539_2	1120917.AQXM01000056_gene739	3.026e-48	174.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,1W7YN@1268|Micrococcaceae	201174|Actinobacteria	V	ABC transporter	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
MMS1_k127_2466762_1	1480694.DC28_01765	3.781e-22	98.0	COG4401@1|root,COG4401@2|Bacteria,2J8DE@203691|Spirochaetes	203691|Spirochaetes	E	chorismate mutase	aroH	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
MMS1_k127_2466762_0	1123371.ATXH01000021_gene1119	8.99e-87	304.0	COG0297@1|root,COG0297@2|Bacteria,2GI6I@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	Starch synthase catalytic domain	-	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
MMS1_k127_2467615_3	1042156.CXIVA_11210	2.464e-83	282.0	COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,36H12@31979|Clostridiaceae	186801|Clostridia	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
MMS1_k127_2467615_5	1042156.CXIVA_11220	2.258e-31	126.0	COG1146@1|root,COG1146@2|Bacteria,1VETY@1239|Firmicutes,25E51@186801|Clostridia,36NCT@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
MMS1_k127_2467615_0	994573.T472_0206530	5.241e-168	534.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36EW0@31979|Clostridiaceae	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMS1_k127_2467615_1	536227.CcarbDRAFT_2465	1.167e-142	455.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,36DRF@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS1_k127_2467615_2	742738.HMPREF9460_03467	5.18e-92	307.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,26BJB@186813|unclassified Clostridiales	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMS1_k127_2467615_4	319795.Dgeo_2783	8.748e-52	189.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_2468530_1	1304885.AUEY01000021_gene3472	7.749e-54	204.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria,2MIK0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
MMS1_k127_2468530_0	572544.Ilyop_1610	1.142e-174	554.0	COG0604@1|root,COG0604@2|Bacteria,37AVI@32066|Fusobacteria	32066|Fusobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
MMS1_k127_2468530_2	748224.HMPREF9436_00482	8.03e-07	51.0	COG0657@1|root,COG0657@2|Bacteria,1TP1H@1239|Firmicutes,24D7F@186801|Clostridia,3WIPT@541000|Ruminococcaceae	186801|Clostridia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
MMS1_k127_2470915_1	1033743.CAES01000046_gene327	2.133e-15	84.0	2CKD9@1|root,333BQ@2|Bacteria,1VIGZ@1239|Firmicutes,4HQNF@91061|Bacilli,26RC6@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2470915_0	68170.KL590548_gene3352	1.444e-37	153.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4DZ0A@85010|Pseudonocardiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
MMS1_k127_2473274_0	1480694.DC28_14875	1.261e-79	276.0	COG0454@1|root,COG0456@2|Bacteria,2J7A2@203691|Spirochaetes	203691|Spirochaetes	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_2473274_1	717606.PaecuDRAFT_0083	2.284e-41	161.0	COG0491@1|root,COG0491@2|Bacteria,1V2XF@1239|Firmicutes	1239|Firmicutes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_2473274_2	861208.AGROH133_02911	1.053e-09	69.0	COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2TR4M@28211|Alphaproteobacteria,4B7BX@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
MMS1_k127_2475_0	138119.DSY4732	6.027e-239	747.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,266YR@186807|Peptococcaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
MMS1_k127_2475_1	1121468.AUBR01000024_gene3045	1.12e-77	264.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,42FSM@68295|Thermoanaerobacterales	186801|Clostridia	I	dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS1_k127_2476082_1	933115.GPDM_01760	4.009e-111	369.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,4HATK@91061|Bacilli,26E2M@186818|Planococcaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabHB	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
MMS1_k127_2476082_3	227377.CBU_0818	1.891e-25	114.0	COG1309@1|root,COG1309@2|Bacteria,1QIJW@1224|Proteobacteria,1SDIA@1236|Gammaproteobacteria,1JE9Y@118969|Legionellales	118969|Legionellales	K	transcriptional regulator, TetR family	yxaF	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
MMS1_k127_2476082_0	1307761.L21SP2_0425	1.639e-153	496.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_2476082_4	1280676.AUJO01000003_gene138	2.22e-10	69.0	COG2091@1|root,COG2091@2|Bacteria,1VEYZ@1239|Firmicutes,24RQ3@186801|Clostridia,4BZSC@830|Butyrivibrio	186801|Clostridia	H	4'-phosphopantetheinyl transferase superfamily	sfp	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
MMS1_k127_2476082_2	1123274.KB899411_gene3193	2.903e-49	179.0	COG2236@1|root,COG2236@2|Bacteria,2JAE0@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
MMS1_k127_2476817_1	665571.STHERM_c18910	3.388e-32	128.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
MMS1_k127_2476817_0	573413.Spirs_0275	2.917e-203	644.0	COG0077@1|root,COG2876@1|root,COG0077@2|Bacteria,COG2876@2|Bacteria,2J644@203691|Spirochaetes	203691|Spirochaetes	H	PFAM DAHP synthetase I KDSA	pheA	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,DAHP_synth_1,PDT
MMS1_k127_2480657_2	59374.Fisuc_2714	5.763e-54	194.0	COG0440@1|root,COG0440@2|Bacteria	2|Bacteria	E	acetolactate synthase activity	hom	-	1.1.1.3,2.2.1.6	ko:K00003,ko:K01653	ko00260,ko00270,ko00290,ko00300,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00270,map00290,map00300,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230	M00017,M00018,M00019,M00570	R00006,R00014,R00226,R01773,R01775,R03050,R04672,R04673,R08648	RC00027,RC00087,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C,Homoserine_dh,MFS_1,NAD_binding_3
MMS1_k127_2480657_0	1480694.DC28_00510	1.214e-270	842.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS1_k127_2480657_1	203119.Cthe_0322	3.821e-84	288.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,3WG7U@541000|Ruminococcaceae	186801|Clostridia	G	Hydrolase Family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
MMS1_k127_2480804_1	1499967.BAYZ01000005_gene5440	2.262e-91	306.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
MMS1_k127_2480804_2	1499967.BAYZ01000005_gene5439	2.24e-87	292.0	COG1410@1|root,COG1410@2|Bacteria	2|Bacteria	E	methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
MMS1_k127_2480804_3	1499967.BAYZ01000005_gene5438	2.279e-86	301.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
MMS1_k127_2480804_0	324602.Caur_1297	1.352e-118	393.0	COG0477@1|root,COG2814@2|Bacteria,2G6UA@200795|Chloroflexi	200795|Chloroflexi	EGP	TIGRFAM drug resistance transporter, Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
MMS1_k127_2480804_4	589924.Ferp_1748	2.658e-22	102.0	COG0633@1|root,COG3894@1|root,arCOG02035@2157|Archaea,arCOG02842@2157|Archaea,2XVBE@28890|Euryarchaeota,246NQ@183980|Archaeoglobi	183980|Archaeoglobi	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
MMS1_k127_2482952_5	1121396.KB893079_gene825	1.886e-53	202.0	COG1032@1|root,COG1032@2|Bacteria,1PDZR@1224|Proteobacteria,42M73@68525|delta/epsilon subdivisions,2WK6Y@28221|Deltaproteobacteria,2MKQE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS1_k127_2482952_6	313606.M23134_01670	3.885e-26	112.0	2DR5T@1|root,33AAK@2|Bacteria,4NYW7@976|Bacteroidetes,47T3U@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
MMS1_k127_2482952_0	292459.STH2847	2.266e-108	361.0	COG0596@1|root,COG0596@2|Bacteria,1UJB0@1239|Firmicutes,25F07@186801|Clostridia	186801|Clostridia	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
MMS1_k127_2482952_4	443254.Marpi_1265	7.113e-54	205.0	COG1309@1|root,COG1309@2|Bacteria,2GD9U@200918|Thermotogae	200918|Thermotogae	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_2482952_1	1469948.JPNB01000001_gene817	2.234e-105	349.0	COG0561@1|root,COG0561@2|Bacteria,1UYFN@1239|Firmicutes,249JT@186801|Clostridia,36GUP@31979|Clostridiaceae	186801|Clostridia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
MMS1_k127_2482952_2	1265505.ATUG01000001_gene4149	2.574e-99	333.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2MI9X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS1_k127_2482952_3	868131.MSWAN_1006	2.992e-57	203.0	COG0262@1|root,arCOG01490@2157|Archaea,2XZSN@28890|Euryarchaeota	28890|Euryarchaeota	H	Bifunctional deaminase-reductase	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
MMS1_k127_2484028_3	373994.Riv7116_0153	3.311e-48	181.0	COG0517@1|root,COG2199@1|root,COG0517@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS,GAF,GGDEF,HAMP,PAS_3,PAS_4,PAS_9,dCache_1
MMS1_k127_2484028_4	359.CN09_02425	8.088e-35	138.0	COG1846@1|root,COG1846@2|Bacteria,1RI74@1224|Proteobacteria,2UAPB@28211|Alphaproteobacteria,4BFWH@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_2484028_2	216591.BCAM1751	3.418e-54	196.0	COG1335@1|root,COG1335@2|Bacteria,1QK2B@1224|Proteobacteria,2VQN5@28216|Betaproteobacteria,1K3WV@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS1_k127_2484028_1	1304275.C41B8_14045	5.471e-70	252.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2484028_0	744872.Spica_1845	1.288e-209	670.0	COG0737@1|root,COG0737@2|Bacteria,2J5ZK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
MMS1_k127_2484028_5	1174528.JH992898_gene1550	1.881e-17	94.0	COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1JI55@1189|Stigonemataceae	1117|Cyanobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	htrA	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMS1_k127_2486029_0	986075.CathTA2_1322	1.081e-75	271.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4HE36@91061|Bacilli	91061|Bacilli	G	C4-dicarboxylate ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
MMS1_k127_2486029_3	1288298.rosmuc_04042	1.375e-18	97.0	COG4663@1|root,COG4663@2|Bacteria,1PJG3@1224|Proteobacteria,2VBBI@28211|Alphaproteobacteria,46RDS@74030|Roseovarius	28211|Alphaproteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
MMS1_k127_2486029_2	1256908.HMPREF0373_00333	2.412e-51	189.0	COG0778@1|root,COG0778@2|Bacteria,1VDE9@1239|Firmicutes,24QEX@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_2486029_1	158190.SpiGrapes_0250	1.445e-58	219.0	COG4097@1|root,COG4097@2|Bacteria,2JAX7@203691|Spirochaetes	203691|Spirochaetes	P	Oxidoreductase, NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
MMS1_k127_2487837_1	86416.Clopa_3997	7.687e-86	301.0	COG1621@1|root,COG1621@2|Bacteria,1VRC9@1239|Firmicutes,24XS0@186801|Clostridia,36QY1@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolases family 32 C terminal	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32C,Glyco_hydro_32N
MMS1_k127_2487837_2	709991.Odosp_2767	4.65e-29	121.0	COG0824@1|root,COG0824@2|Bacteria,4NSJR@976|Bacteroidetes,2FS2E@200643|Bacteroidia,22Y6W@171551|Porphyromonadaceae	976|Bacteroidetes	S	acyl-CoA thioester hydrolase, YbgC YbaW family	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
MMS1_k127_2487837_0	1192034.CAP_6017	5.247e-166	531.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,42RYP@68525|delta/epsilon subdivisions,2WNDE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the amidase family	gatA3	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
MMS1_k127_2495665_2	1499967.BAYZ01000184_gene4583	3.354e-81	273.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_2495665_0	1499967.BAYZ01000184_gene4582	5.975e-146	467.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
MMS1_k127_2495665_1	1499967.BAYZ01000184_gene4581	1.297e-124	404.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2495665_4	573413.Spirs_1365	4.029e-45	171.0	COG1011@1|root,COG1011@2|Bacteria,2J7J2@203691|Spirochaetes	203691|Spirochaetes	E	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_2495665_3	1410668.JNKC01000002_gene2150	2.473e-65	233.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24BBP@186801|Clostridia,36HNT@31979|Clostridiaceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_2497677_1	573413.Spirs_0555	8.026e-101	347.0	COG3845@1|root,COG3845@2|Bacteria,2J6DN@203691|Spirochaetes	203691|Spirochaetes	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
MMS1_k127_2497677_2	573413.Spirs_0556	3.793e-92	314.0	COG1744@1|root,COG1744@2|Bacteria,2J572@203691|Spirochaetes	203691|Spirochaetes	S	Basic membrane protein	tpn38b	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
MMS1_k127_2497677_0	744872.Spica_0275	1.062e-162	521.0	COG0462@1|root,COG0462@2|Bacteria,2J5IY@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the ribose-phosphate pyrophosphokinase family	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
MMS1_k127_2497677_3	1123274.KB899408_gene3888	0.0006689	46.0	COG1070@1|root,COG1070@2|Bacteria,2J7TG@203691|Spirochaetes	203691|Spirochaetes	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_2497778_0	1304885.AUEY01000087_gene94	1.057e-61	224.0	COG2199@1|root,COG3706@2|Bacteria,1RERI@1224|Proteobacteria,42S3X@68525|delta/epsilon subdivisions,2WNF2@28221|Deltaproteobacteria,2MNCH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2982	GGDEF
MMS1_k127_2497778_1	292459.STH2021	1.638e-36	153.0	COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,249KP@186801|Clostridia	186801|Clostridia	V	beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,Cu_amine_oxidN1,DUF3471
MMS1_k127_2499848_1	1304284.L21TH_0213	3.627e-41	168.0	COG1193@1|root,COG1193@2|Bacteria,1TSBW@1239|Firmicutes,24814@186801|Clostridia,36FV5@31979|Clostridiaceae	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
MMS1_k127_2499848_0	273068.TTE0726	1.724e-133	434.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,42I4U@68295|Thermoanaerobacterales	186801|Clostridia	F	D-Lysine 5,6-aminomutase alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
MMS1_k127_2502854_4	1123279.ATUS01000005_gene3233	6.085e-35	143.0	COG1865@1|root,COG1865@2|Bacteria,1RJXU@1224|Proteobacteria,1SBM6@1236|Gammaproteobacteria,1J7A0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Adenosylcobinamide amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CbiZ
MMS1_k127_2502854_2	485916.Dtox_0537	2.86e-74	257.0	COG2020@1|root,COG2020@2|Bacteria,1V0PB@1239|Firmicutes,25CSA@186801|Clostridia	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2502854_0	879212.DespoDRAFT_02546	3.828e-146	472.0	COG1373@1|root,COG1373@2|Bacteria,1R9U4@1224|Proteobacteria,42ZPX@68525|delta/epsilon subdivisions,2WV2B@28221|Deltaproteobacteria,2MND9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
MMS1_k127_2502854_1	349521.HCH_02824	2.064e-77	266.0	COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria,1S5FF@1236|Gammaproteobacteria,1XK9F@135619|Oceanospirillales	135619|Oceanospirillales	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_2502854_5	930169.B5T_00309	2.658e-26	109.0	COG1942@1|root,COG1942@2|Bacteria,1RDK8@1224|Proteobacteria,1S4BI@1236|Gammaproteobacteria,1XK8M@135619|Oceanospirillales	135619|Oceanospirillales	S	Tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_2
MMS1_k127_2502854_6	1196322.A370_00376	7.779e-12	66.0	2EG7C@1|root,339Z9@2|Bacteria,1W3NP@1239|Firmicutes,254RI@186801|Clostridia,36TM6@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2502854_3	889378.Spiaf_1779	1.571e-54	195.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_2506297_1	1123274.KB899419_gene1918	1.984e-37	149.0	COG2199@1|root,COG3706@2|Bacteria,2J8YI@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2506297_0	573413.Spirs_2541	1.029e-54	201.0	2F8HF@1|root,340W9@2|Bacteria,2J5EY@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_251278_1	665571.STHERM_c14890	1.86e-59	213.0	COG1249@1|root,COG1249@2|Bacteria,2J7JJ@203691|Spirochaetes	203691|Spirochaetes	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS1_k127_251278_0	545694.TREPR_1182	4.643e-119	399.0	COG0514@1|root,COG0514@2|Bacteria,2J5BY@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
MMS1_k127_2515142_4	744872.Spica_1200	1.67e-58	207.0	COG0294@1|root,COG0294@2|Bacteria,2J6FQ@203691|Spirochaetes	203691|Spirochaetes	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMS1_k127_2515142_0	1307761.L21SP2_2416	2.633e-85	291.0	COG1624@1|root,COG1624@2|Bacteria,2J5ZB@203691|Spirochaetes	203691|Spirochaetes	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
MMS1_k127_2515142_2	573413.Spirs_1648	9.661e-74	259.0	COG4856@1|root,COG4856@2|Bacteria,2J5XW@203691|Spirochaetes	203691|Spirochaetes	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
MMS1_k127_2515142_1	1307761.L21SP2_2413	3.097e-82	282.0	COG1655@1|root,COG1655@2|Bacteria,2J5GN@203691|Spirochaetes	203691|Spirochaetes	S	protein conserved in bacteria	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225
MMS1_k127_2515142_3	1307761.L21SP2_2412	7.703e-72	250.0	COG0101@1|root,COG0101@2|Bacteria,2J65Z@203691|Spirochaetes	203691|Spirochaetes	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMS1_k127_2517709_2	1280666.ATVS01000005_gene2375	0.0004414	48.0	COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24SVC@186801|Clostridia,4C20D@830|Butyrivibrio	186801|Clostridia	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMS1_k127_2517709_0	1122223.KB890700_gene1975	1.549e-97	329.0	COG0009@1|root,COG0009@2|Bacteria,1WJN4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
MMS1_k127_2517709_1	351160.RCIX1713	1.816e-37	156.0	arCOG05183@1|root,arCOG05183@2157|Archaea,2Y7NI@28890|Euryarchaeota,2NAMV@224756|Methanomicrobia	224756|Methanomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS,PAS_9,PocR
MMS1_k127_2521641_1	338963.Pcar_1174	1.324e-05	50.0	COG1366@1|root,COG2199@1|root,COG1366@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42UVA@68525|delta/epsilon subdivisions,2X619@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_2521641_0	1047013.AQSP01000100_gene587	1.003e-92	319.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_2527184_3	1121396.KB893063_gene1200	9.268e-31	133.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_2527184_1	1121403.AUCV01000044_gene54	1.121e-77	272.0	COG2984@1|root,COG2984@2|Bacteria,1R84M@1224|Proteobacteria,42PKD@68525|delta/epsilon subdivisions,2WMBV@28221|Deltaproteobacteria,2MJYP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
MMS1_k127_2527184_2	395493.BegalDRAFT_2636	2.17e-72	252.0	COG1335@1|root,COG1335@2|Bacteria,1RCGZ@1224|Proteobacteria,1SPB0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2527184_0	398720.MED217_02010	4.044e-81	291.0	COG1305@1|root,COG1305@2|Bacteria,4NF37@976|Bacteroidetes,1IIST@117743|Flavobacteriia	976|Bacteroidetes	E	Protein of unknown function (DUF2569)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2569,DUF3857,Transglut_core
MMS1_k127_2528033_0	1278307.KB906994_gene2888	1.481e-39	151.0	COG0834@1|root,COG0834@2|Bacteria,1RJ5A@1224|Proteobacteria,1S6WZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Amino acid ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_2528033_1	1499967.BAYZ01000184_gene4608	5.248e-32	133.0	COG0477@1|root,COG1413@1|root,COG1413@2|Bacteria,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	DNA_alkylation,HEAT_2,MFS_1,cNMP_binding
MMS1_k127_2529042_4	926561.KB900617_gene1705	1.093e-08	59.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,3WAQ6@53433|Halanaerobiales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS1_k127_2529042_3	411467.BACCAP_00109	1.785e-99	336.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,267UR@186813|unclassified Clostridiales	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMS1_k127_2529042_1	1313304.CALK_2039	4.019e-147	471.0	COG0379@1|root,COG0379@2|Bacteria	2|Bacteria	H	quinolinate synthetase A activity	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
MMS1_k127_2529042_2	1541960.KQ78_00620	5.805e-136	440.0	COG4211@1|root,COG4211@2|Bacteria,3WV53@544448|Tenericutes	544448|Tenericutes	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
MMS1_k127_2529042_0	1541960.KQ78_00621	1.1e-150	483.0	COG1129@1|root,COG1129@2|Bacteria,3WSXT@544448|Tenericutes	544448|Tenericutes	G	ABC transporter	xylG	-	3.6.3.17	ko:K02056,ko:K10548	ko02010,map02010	M00216,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.5	-	-	ABC_tran
MMS1_k127_2529286_1	1499684.CCNP01000023_gene3287	5.937e-41	163.0	COG0084@1|root,COG0084@2|Bacteria,1V29B@1239|Firmicutes,247TV@186801|Clostridia,36E0Q@31979|Clostridiaceae	186801|Clostridia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
MMS1_k127_2529286_0	1047013.AQSP01000048_gene2216	5.122e-55	201.0	COG3279@1|root,COG3279@2|Bacteria,2NRAD@2323|unclassified Bacteria	2|Bacteria	KT	LytTr DNA-binding domain	coxC	GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007	-	ko:K02477,ko:K07705,ko:K21696	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022,ko03000	-	-	-	LytTR,MHYT,Response_reg
MMS1_k127_2529286_2	1121898.Q766_00725	2.647e-33	145.0	COG2972@1|root,COG2972@2|Bacteria,4NIER@976|Bacteroidetes,1IIPA@117743|Flavobacteriia	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
MMS1_k127_2531394_2	1200792.AKYF01000018_gene5769	2.219e-15	76.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HBSC@91061|Bacilli,26S4H@186822|Paenibacillaceae	91061|Bacilli	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	mprA3	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_2531394_0	1501230.ET33_29445	5.413e-74	262.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4IS5F@91061|Bacilli,2772D@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	sasA	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMS1_k127_2531394_1	1304885.AUEY01000022_gene3379	2.316e-72	254.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2MHKM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent DNA helicase, RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,UvrD-helicase,UvrD_C
MMS1_k127_2536702_0	428125.CLOLEP_00889	1.087e-82	285.0	COG5026@1|root,COG5026@2|Bacteria,1TRWA@1239|Firmicutes,24BV4@186801|Clostridia	186801|Clostridia	G	PFAM hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
MMS1_k127_2537243_0	1125699.HMPREF9194_01817	6.572e-140	456.0	COG1593@1|root,COG1593@2|Bacteria,2J73D@203691|Spirochaetes	203691|Spirochaetes	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
MMS1_k127_2537243_3	367336.OM2255_04780	1.006e-10	68.0	COG3090@1|root,COG3090@2|Bacteria,1RE57@1224|Proteobacteria,2U7GP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
MMS1_k127_2537243_1	158190.SpiGrapes_2645	7.708e-109	361.0	COG1638@1|root,COG1638@2|Bacteria,2J7YC@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
MMS1_k127_2537243_2	573413.Spirs_1347	2.694e-26	110.0	COG2186@1|root,COG2186@2|Bacteria,2J7JW@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
MMS1_k127_2537601_1	118161.KB235922_gene1584	2.362e-30	123.0	COG1670@1|root,COG1670@2|Bacteria,1GRPA@1117|Cyanobacteria,3VN9Y@52604|Pleurocapsales	1117|Cyanobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2537601_2	221288.JH992901_gene1179	1.158e-14	77.0	COG1670@1|root,COG1670@2|Bacteria,1G8RY@1117|Cyanobacteria	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
MMS1_k127_2537601_3	1380384.JADN01000004_gene2372	5.347e-10	74.0	COG2374@1|root,COG4085@1|root,COG2374@2|Bacteria,COG4085@2|Bacteria,4NIB0@976|Bacteroidetes,1HWVQ@117743|Flavobacteriia	976|Bacteroidetes	F	endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	DUF5017,LTD
MMS1_k127_2537601_0	1174528.JH992898_gene4471	2.36e-162	551.0	COG2374@1|root,COG2931@1|root,COG2374@2|Bacteria,COG2931@2|Bacteria,1GHDU@1117|Cyanobacteria,1JKFU@1189|Stigonemataceae	1117|Cyanobacteria	Q	Lamin Tail Domain	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Calx-beta,Exo_endo_phos,HemolysinCabind,LTD
MMS1_k127_253957_1	545694.TREPR_2465	6.712e-71	254.0	COG0535@1|root,COG0535@2|Bacteria,2J6HP@203691|Spirochaetes	203691|Spirochaetes	S	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
MMS1_k127_253957_0	545694.TREPR_2466	1.493e-116	387.0	COG1570@1|root,COG1570@2|Bacteria,2J5ED@203691|Spirochaetes	203691|Spirochaetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
MMS1_k127_253957_3	1236959.BAMT01000002_gene2270	0.0005687	47.0	COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,2KN7U@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
MMS1_k127_253957_2	937774.TEQUI_0062	1.887e-28	117.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,3T4GB@506|Alcaligenaceae	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
MMS1_k127_2541959_1	573413.Spirs_1821	6.401e-45	169.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,2J6N2@203691|Spirochaetes	203691|Spirochaetes	NT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	cheA-1	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
MMS1_k127_2541959_2	882.DVU_1431	1.062e-06	55.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	2.4.1.187	ko:K03409,ko:K05946	ko02030,ko05111,map02030,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02035	-	GT26	-	ANTAR,Glyco_tran_WecB,HATPase_c_2,PAS_3,STAS,STAS_2
MMS1_k127_2541959_0	1123274.KB899415_gene2434	4.656e-118	398.0	COG0265@1|root,COG0265@2|Bacteria,2J5SD@203691|Spirochaetes	203691|Spirochaetes	O	Trypsin domain PDZ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMS1_k127_2542458_2	1307761.L21SP2_3111	7.099e-137	479.0	COG3210@1|root,COG3210@2|Bacteria,2JBDG@203691|Spirochaetes	203691|Spirochaetes	U	domain, Protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	-
MMS1_k127_2542458_0	526218.Sterm_1664	5.248e-214	668.0	COG0078@1|root,COG0078@2|Bacteria,37BG2@32066|Fusobacteria	32066|Fusobacteria	E	Belongs to the ATCase OTCase family	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
MMS1_k127_2542458_1	1487923.DP73_03275	1.643e-138	447.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,264F3@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS1_k127_2542458_3	521011.Mpal_0492	1.083e-76	264.0	COG1584@1|root,arCOG03176@2157|Archaea,2XWNC@28890|Euryarchaeota,2N9MY@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMS1_k127_2542458_8	1121468.AUBR01000039_gene1935	5.796e-18	86.0	COG4636@1|root,COG4636@2|Bacteria,1V46Z@1239|Firmicutes,24I1U@186801|Clostridia	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
MMS1_k127_2542458_6	1216932.CM240_3074	2.021e-26	120.0	COG1600@1|root,COG1600@2|Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
MMS1_k127_2542458_7	1499967.BAYZ01000097_gene4370	5.722e-20	96.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	HTH_27,MarR,MarR_2
MMS1_k127_2542458_5	1349785.BAUG01000004_gene379	3.885e-34	145.0	COG3146@1|root,COG3146@2|Bacteria,4NI7H@976|Bacteroidetes,1I0KW@117743|Flavobacteriia	976|Bacteroidetes	S	8-amino-7-oxononanoate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
MMS1_k127_2542458_9	996306.SSUR61_0623	8.044e-16	83.0	COG0454@1|root,COG0456@2|Bacteria,1V6P2@1239|Firmicutes,4HIWN@91061|Bacilli,1WTGP@1307|Streptococcus suis	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS1_k127_2542458_4	1123277.KB893172_gene964	8.668e-51	196.0	COG2207@1|root,COG2207@2|Bacteria,4NIIK@976|Bacteroidetes,47MA0@768503|Cytophagia	976|Bacteroidetes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_2547365_2	744872.Spica_0239	7.485e-55	197.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
MMS1_k127_2547365_1	889378.Spiaf_2778	3.373e-62	221.0	COG0793@1|root,COG0793@2|Bacteria,2J5QD@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the peptidase S41A family	ctp	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
MMS1_k127_2547365_0	1123274.KB899407_gene346	2.781e-138	449.0	COG0455@1|root,COG0455@2|Bacteria,2J5K5@203691|Spirochaetes	203691|Spirochaetes	D	ATP-binding protein	ylxH-2	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA,ParA
MMS1_k127_2547365_3	744872.Spica_0243	1.964e-29	118.0	COG0682@1|root,COG0682@2|Bacteria,2J58I@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
MMS1_k127_2547692_1	879305.HMPREF9290_0192	0.0008483	42.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,22GA4@1570339|Peptoniphilaceae	186801|Clostridia	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
MMS1_k127_2547692_0	1196322.A370_01188	1.152e-100	352.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,HisKA_7TM,PAS_3,PocR,dCache_1
MMS1_k127_2551698_2	1125863.JAFN01000001_gene2784	5.754e-06	49.0	COG1396@1|root,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,43AXU@68525|delta/epsilon subdivisions,2X6C0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
MMS1_k127_2551698_0	1124982.MSI_22500	1.622e-213	670.0	COG0065@1|root,COG0065@2|Bacteria,2J5AM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
MMS1_k127_2551698_1	720554.Clocl_2901	1.194e-72	248.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,3WIGV@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMS1_k127_2554645_0	760192.Halhy_5549	1.008e-64	227.0	COG2207@1|root,COG2207@2|Bacteria,4NEHD@976|Bacteroidetes,1IQHR@117747|Sphingobacteriia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_2555167_1	331113.SNE_A04330	1.138e-39	153.0	COG1373@1|root,COG1373@2|Bacteria,2JGKT@204428|Chlamydiae	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_2555167_3	991.IW20_19600	2.775e-20	93.0	291T4@1|root,2ZPD1@2|Bacteria,4P70Y@976|Bacteroidetes,1IDV1@117743|Flavobacteriia,2NZA3@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF3781)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3781
MMS1_k127_2555167_4	391623.TERMP_01526	1.713e-06	59.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,2434U@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2555167_0	1449063.JMLS01000049_gene3786	4.903e-125	409.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,4HB61@91061|Bacilli,271HG@186822|Paenibacillaceae	91061|Bacilli	EF	N-terminal domain of ribose phosphate pyrophosphokinase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyl_synth,Pribosyltran_N
MMS1_k127_2555167_2	221288.JH992901_gene3312	3.3e-36	139.0	2DNRM@1|root,32YT2@2|Bacteria,1G8M2@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
MMS1_k127_2566053_1	555779.Dthio_PD0968	3.167e-65	235.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria,2MG10@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
MMS1_k127_2566053_0	744872.Spica_0065	1.119e-165	531.0	2BXG3@1|root,2Z82R@2|Bacteria,2J6D3@203691|Spirochaetes	203691|Spirochaetes	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
MMS1_k127_2566279_0	1123274.KB899414_gene3732	0.0	1063.0	COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_2566279_1	1307761.L21SP2_3270	5.677e-76	262.0	COG0467@1|root,COG0467@2|Bacteria,2J5KM@203691|Spirochaetes	203691|Spirochaetes	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25,ATPase
MMS1_k127_2566279_2	1353529.M899_3332	4.111e-16	79.0	COG4807@1|root,COG4807@2|Bacteria,1RD33@1224|Proteobacteria,42UNP@68525|delta/epsilon subdivisions,2MUFN@213481|Bdellovibrionales,2WQ4E@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Protein of unknown function (DUF1456)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1456
MMS1_k127_2568112_2	1348663.KCH_11390	2.275e-66	230.0	COG1028@1|root,COG1028@2|Bacteria,2GWHQ@201174|Actinobacteria,2M4FF@2063|Kitasatospora	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_2568112_3	864565.HMPREF0379_0989	7.473e-43	162.0	COG1695@1|root,COG1695@2|Bacteria,1V4KT@1239|Firmicutes,24954@186801|Clostridia	186801|Clostridia	K	PFAM Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
MMS1_k127_2568112_0	1209989.TepiRe1_0818	3.265e-155	507.0	COG0655@1|root,COG3255@1|root,COG0655@2|Bacteria,COG3255@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,42GK8@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_2568112_1	665571.STHERM_c01870	1.152e-70	251.0	2EVQY@1|root,33P4X@2|Bacteria,2J6X8@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2568112_4	880073.Calab_3479	2.576e-36	140.0	COG3118@1|root,COG3118@2|Bacteria,2NPNZ@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMS1_k127_2568112_6	906968.Trebr_0560	0.0001454	46.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
MMS1_k127_2568869_1	1122917.KB899686_gene3267	2.117e-64	235.0	COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,4HB5X@91061|Bacilli,26RVA@186822|Paenibacillaceae	91061|Bacilli	G	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate	rhaB	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_2568869_0	1131730.BAVI_18372	3.342e-298	923.0	COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,4HB1E@91061|Bacilli,1ZE63@1386|Bacillus	91061|Bacilli	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	fucI	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
MMS1_k127_2568869_2	1168034.FH5T_00935	6.103e-45	175.0	COG2207@1|root,COG2207@2|Bacteria,4NHZP@976|Bacteroidetes,2G12F@200643|Bacteroidia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18,HTH_AraC
MMS1_k127_2568869_3	869209.Tresu_2418	3.208e-30	130.0	COG0745@1|root,COG0745@2|Bacteria,2J6F9@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS1_k127_2573258_2	1487953.JMKF01000013_gene6278	0.0001058	55.0	COG3049@1|root,COG3049@2|Bacteria	2|Bacteria	M	Linear amide C-N hydrolases, choloylglycine hydrolase family	-	-	3.5.1.24	ko:K01442	ko00120,ko00121,ko01100,map00120,map00121,map01100	-	R02797,R03975,R03977,R04486,R04487,R05835	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	AAT,CBAH
MMS1_k127_2573258_1	545694.TREPR_1265	9.46e-83	284.0	COG2086@1|root,COG2086@2|Bacteria,2J6CP@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein	etfB	-	1.3.1.108	ko:K03521,ko:K22431	-	-	-	-	ko00000,ko01000	-	-	-	ETF
MMS1_k127_2573258_0	545694.TREPR_1266	9.201e-86	293.0	COG2025@1|root,COG2025@2|Bacteria,2J5XR@203691|Spirochaetes	203691|Spirochaetes	C	Electron transfer flavoprotein, alpha subunit	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS1_k127_2574145_2	1480694.DC28_10070	1.159e-32	128.0	COG0537@1|root,COG0537@2|Bacteria,2J92I@203691|Spirochaetes	203691|Spirochaetes	FG	histidine triad	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMS1_k127_2574145_3	1345695.CLSA_c37380	6.938e-10	68.0	COG2340@1|root,COG5263@1|root,COG2340@2|Bacteria,COG5263@2|Bacteria,1V6GZ@1239|Firmicutes,24I20@186801|Clostridia,36VHI@31979|Clostridiaceae	186801|Clostridia	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CW_binding_1
MMS1_k127_2574145_0	631362.Thi970DRAFT_01365	1.836e-151	497.0	COG0426@1|root,COG2199@1|root,COG0426@2|Bacteria,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1WXES@135613|Chromatiales	135613|Chromatiales	CT	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_2574145_1	1123274.KB899421_gene1737	2.023e-78	272.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_acc,DAGK_cat
MMS1_k127_2575309_0	1129794.C427_1018	2.576e-35	153.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RN52@1236|Gammaproteobacteria,4659D@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG0642 Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
MMS1_k127_2575309_1	1307761.L21SP2_0193	2.805e-30	122.0	COG0629@1|root,COG0629@2|Bacteria,2J86A@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
MMS1_k127_2578182_3	1480694.DC28_09110	1.503e-38	159.0	COG1721@1|root,COG1721@2|Bacteria,2J8BC@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_2578182_0	1307761.L21SP2_0021	2.582e-109	364.0	COG0714@1|root,COG0714@2|Bacteria,2J65W@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_2578182_2	646529.Desaci_2528	2.677e-46	178.0	COG0500@1|root,COG2226@2|Bacteria,1V6G6@1239|Firmicutes,24H8Z@186801|Clostridia,26359@186807|Peptococcaceae	186801|Clostridia	H	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS1_k127_2578182_1	644282.Deba_1109	8.876e-69	242.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42S0M@68525|delta/epsilon subdivisions,2WNYE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	yheT	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6
MMS1_k127_2579950_0	1121012.AUKX01000034_gene644	1.013e-106	352.0	COG3007@1|root,COG3007@2|Bacteria,4NFV8@976|Bacteroidetes,1HZGS@117743|Flavobacteriia,23G2U@178469|Arenibacter	976|Bacteroidetes	I	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	fabV	-	1.3.1.44,1.3.1.9	ko:K00209	ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212	M00083	R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase
MMS1_k127_2579950_1	158189.SpiBuddy_2870	1.337e-42	163.0	COG1309@1|root,COG1309@2|Bacteria,2J7BQ@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_2579950_2	179408.Osc7112_4430	3.409e-22	98.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GD97@1117|Cyanobacteria,1HEHM@1150|Oscillatoriales	1117|Cyanobacteria	KLT	SMART Serine threonine-protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,HATPase_c,HisKA,Pkinase,Response_reg
MMS1_k127_2581622_2	573413.Spirs_0100	5.709e-12	66.0	COG1435@1|root,COG1435@2|Bacteria,2J6SK@203691|Spirochaetes	203691|Spirochaetes	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
MMS1_k127_2581622_0	573413.Spirs_0300	3.261e-161	514.0	COG1816@1|root,COG1816@2|Bacteria,2J9QW@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
MMS1_k127_2581622_1	744872.Spica_1085	7.161e-123	420.0	COG0666@1|root,COG0666@2|Bacteria,2J5FX@203691|Spirochaetes	203691|Spirochaetes	S	Ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
MMS1_k127_2583919_2	1123274.KB899414_gene3687	4.346e-48	176.0	COG1533@1|root,COG1533@2|Bacteria,2J9M1@203691|Spirochaetes	203691|Spirochaetes	L	DNA photolyase activity	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS1_k127_2583919_1	889378.Spiaf_2505	8.81e-59	211.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	plsC	-	2.3.1.51,2.7.4.25	ko:K00655,ko:K00945	ko00240,ko00561,ko00564,ko01100,ko01110,map00240,map00561,map00564,map01100,map01110	M00052,M00089	R00158,R00512,R01665,R02241,R09381	RC00002,RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
MMS1_k127_2583919_0	1168034.FH5T_14100	4.391e-155	501.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	bamJ	-	-	-	-	-	-	-	-	-	-	iSB619.SA_RS10050	Aminotran_1_2
MMS1_k127_2583919_3	596324.TREVI0001_1737	3.516e-06	55.0	2AMMC@1|root,31CHE@2|Bacteria,2J7BZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2585765_5	926692.AZYG01000056_gene452	8.843e-07	53.0	COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2585765_3	240302.BN982_02453	6.739e-77	275.0	COG1653@1|root,COG1653@2|Bacteria,1UY3R@1239|Firmicutes,4HECM@91061|Bacilli,3ND5H@45667|Halobacillus	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10240	ko02010,map02010	M00206	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.23	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_2585765_2	1304865.JAGF01000001_gene1501	6.538e-101	331.0	COG1335@1|root,COG1335@2|Bacteria,2I9AW@201174|Actinobacteria	201174|Actinobacteria	Q	isochorismatase hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS1_k127_2585765_4	1244869.H261_01776	3.014e-32	134.0	COG1802@1|root,COG1802@2|Bacteria,1N7NH@1224|Proteobacteria,2UFDV@28211|Alphaproteobacteria,2JU2H@204441|Rhodospirillales	204441|Rhodospirillales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_2585765_0	309799.DICTH_0380	6.593e-174	566.0	COG3533@1|root,COG3533@2|Bacteria	2|Bacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
MMS1_k127_2585765_1	1511.CLOST_1319	3.557e-149	478.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia	186801|Clostridia	V	MATE efflux family protein	mepA1	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_2588425_1	1123274.KB899419_gene1942	6.716e-21	102.0	2FJEQ@1|root,34B4E@2|Bacteria,2J8EB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2588425_0	744872.Spica_0294	2.11e-174	556.0	COG1022@1|root,COG1022@2|Bacteria,2J59B@203691|Spirochaetes	203691|Spirochaetes	I	COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming)	faa1	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
MMS1_k127_2591213_0	665571.STHERM_c18560	1.557e-148	486.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
MMS1_k127_2591213_2	484770.UFO1_4458	8.968e-05	50.0	COG2197@1|root,COG2197@2|Bacteria,1V1S2@1239|Firmicutes,4H44A@909932|Negativicutes	909932|Negativicutes	KT	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_2593359_0	667014.Thein_1040	1.514e-132	432.0	COG0840@1|root,COG2768@1|root,COG4624@1|root,COG0840@2|Bacteria,COG2768@2|Bacteria,COG4624@2|Bacteria	2|Bacteria	C	iron-sulfur cluster assembly	-	-	1.12.7.2	ko:K00533,ko:K03616	-	-	R00019	-	ko00000,ko01000	-	-	-	FeS,Fe_hyd_SSU,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_7,MCPsignal
MMS1_k127_2593359_1	272123.Anacy_5616	2.248e-40	165.0	COG2199@1|root,COG3447@1|root,COG3447@2|Bacteria,COG3706@2|Bacteria,1G3NI@1117|Cyanobacteria,1HMYF@1161|Nostocales	1117|Cyanobacteria	T	COGs COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
MMS1_k127_2593625_4	1120953.AUBH01000006_gene2609	0.0008962	48.0	COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria,466UV@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	COG1846 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_2593625_1	722419.PH505_bt00160	3.623e-78	276.0	2C2CS@1|root,2Z7SK@2|Bacteria,1NCSN@1224|Proteobacteria,1RS0D@1236|Gammaproteobacteria,2Q13N@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3754)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3754
MMS1_k127_2593625_3	1150474.JQJI01000001_gene1907	1.54e-62	220.0	COG0311@1|root,COG0311@2|Bacteria,2GCYX@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
MMS1_k127_2593625_0	665571.STHERM_c17110	5.412e-145	465.0	COG0214@1|root,COG0214@2|Bacteria,2J5SI@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
MMS1_k127_2593625_2	518766.Rmar_2433	1.089e-66	235.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,1FJP0@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	B12 binding domain	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
MMS1_k127_2599067_2	573413.Spirs_1456	1.412e-29	124.0	COG4758@1|root,COG4758@2|Bacteria,2JB2D@203691|Spirochaetes	203691|Spirochaetes	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
MMS1_k127_2599067_0	1307761.L21SP2_2528	1.266e-88	304.0	COG0840@1|root,COG0840@2|Bacteria,2J9PB@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,HBM,MCPsignal
MMS1_k127_2599067_3	1123274.KB899418_gene2336	4.199e-10	61.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	fur	-	-	ko:K03711,ko:K09825,ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
MMS1_k127_2605140_2	1123274.KB899411_gene3171	0.0002425	44.0	COG1538@1|root,COG1538@2|Bacteria,2J6ZZ@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
MMS1_k127_2605140_1	573413.Spirs_0899	9.121e-123	403.0	COG0845@1|root,COG0845@2|Bacteria,2J5BM@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
MMS1_k127_2605140_0	573413.Spirs_0900	5.086e-155	496.0	COG0841@1|root,COG0841@2|Bacteria,2J5MZ@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_2615090_2	439235.Dalk_4326	5.801e-68	242.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42QMQ@68525|delta/epsilon subdivisions,2WN4S@28221|Deltaproteobacteria,2MJWK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GGDEF
MMS1_k127_2615090_0	1123274.KB899406_gene1019	4.713e-110	382.0	COG0815@1|root,COG0815@2|Bacteria,2J60T@203691|Spirochaetes	203691|Spirochaetes	M	Transfers the fatty acyl group on membrane lipoproteins	cutE	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
MMS1_k127_2615090_1	158190.SpiGrapes_3172	6.764e-79	272.0	COG2081@1|root,COG2081@2|Bacteria,2J83X@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM flavoprotein, HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
MMS1_k127_2619147_2	1267535.KB906767_gene2918	1.471e-18	90.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_2619147_0	1195236.CTER_4676	6.628e-56	205.0	COG0655@1|root,COG0655@2|Bacteria,1UI36@1239|Firmicutes,247R8@186801|Clostridia,3WM3V@541000|Ruminococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_2619147_1	1123242.JH636435_gene1555	1.313e-46	173.0	COG4099@1|root,COG4099@2|Bacteria,2IZGT@203682|Planctomycetes	203682|Planctomycetes	P	Phospholipase/Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Peptidase_S9
MMS1_k127_2619452_2	1123274.KB899415_gene2498	7.807e-85	285.0	COG0571@1|root,COG0571@2|Bacteria,2J6UI@203691|Spirochaetes	203691|Spirochaetes	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
MMS1_k127_2619452_0	1123274.KB899415_gene2499	5.194e-140	459.0	COG0617@1|root,COG1418@1|root,COG0617@2|Bacteria,COG1418@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
MMS1_k127_2619452_1	545694.TREPR_0296	5.577e-132	425.0	COG1344@1|root,COG1344@2|Bacteria,2J5TJ@203691|Spirochaetes	203691|Spirochaetes	N	Component of the core of the flagella	flaB3	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
MMS1_k127_2619452_3	573413.Spirs_1940	2.501e-50	185.0	COG1564@1|root,COG1564@2|Bacteria,2J7RD@203691|Spirochaetes	203691|Spirochaetes	H	Thiamin pyrophosphokinase, catalytic domain	-	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
MMS1_k127_2619452_4	1480694.DC28_01790	3.019e-19	97.0	297HH@1|root,2ZUQS@2|Bacteria,2JBB5@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5312
MMS1_k127_2619477_0	1480694.DC28_02105	6.899e-202	651.0	28IBY@1|root,2Z8EC@2|Bacteria	2|Bacteria	S	Glycosyl hydrolases related to GH101 family, GH129	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_129
MMS1_k127_2619477_1	1265505.ATUG01000002_gene1814	4.158e-84	285.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43DIC@68525|delta/epsilon subdivisions,2X8Q0@28221|Deltaproteobacteria,2MNS5@213118|Desulfobacterales	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,HATPase_c,HWE_HK,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
MMS1_k127_2620252_0	768670.Calni_1003	2.264e-184	588.0	COG0513@1|root,COG0513@2|Bacteria,2GENS@200930|Deferribacteres	200930|Deferribacteres	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMS1_k127_2620252_1	573413.Spirs_2285	8.906e-20	91.0	2EMZY@1|root,33FN4@2|Bacteria,2J8Y2@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2620252_2	264198.Reut_A0906	2.559e-17	91.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,1K0JS@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Peptidase M48	htpX_2	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
MMS1_k127_2620904_4	1123274.KB899409_gene607	1.722e-72	250.0	COG1086@1|root,COG1086@2|Bacteria,2J5C2@203691|Spirochaetes	203691|Spirochaetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,CoA_binding_3,Polysacc_synt_2
MMS1_k127_2620904_2	573413.Spirs_1331	2.519e-137	447.0	COG0399@1|root,COG0399@2|Bacteria,2J62G@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMS1_k127_2620904_3	545694.TREPR_2358	3.749e-116	401.0	COG1529@1|root,COG1529@2|Bacteria,2J59A@203691|Spirochaetes	203691|Spirochaetes	C	Aldehyde oxidase and xanthine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS1_k127_2620904_6	545694.TREPR_2359	2.095e-33	136.0	COG2080@1|root,COG2080@2|Bacteria,2J7WE@203691|Spirochaetes	203691|Spirochaetes	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS1_k127_2620904_5	573413.Spirs_1328	2.531e-43	170.0	COG1319@1|root,COG1319@2|Bacteria,2J8FR@203691|Spirochaetes	203691|Spirochaetes	C	FAD binding domain in molybdopterin dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_5
MMS1_k127_2620904_0	889378.Spiaf_2225	0.0	1272.0	COG0587@1|root,COG0587@2|Bacteria,2J5B5@203691|Spirochaetes	203691|Spirochaetes	L	DNA-directed DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
MMS1_k127_2620904_7	869209.Tresu_0468	2.875e-21	100.0	COG0762@1|root,COG0762@2|Bacteria,2J8K1@203691|Spirochaetes	203691|Spirochaetes	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
MMS1_k127_2620904_1	665571.STHERM_c08070	1.371e-203	654.0	COG1200@1|root,COG1200@2|Bacteria,2J5ET@203691|Spirochaetes	203691|Spirochaetes	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
MMS1_k127_2620904_8	744872.Spica_1963	2.426e-15	83.0	COG2199@1|root,COG3706@2|Bacteria,2J8FW@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,Response_reg
MMS1_k127_2623474_0	746697.Aeqsu_1960	4.198e-126	420.0	COG0477@1|root,COG0477@2|Bacteria,4PP02@976|Bacteroidetes,1IKCQ@117743|Flavobacteriia	976|Bacteroidetes	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_262482_7	509635.N824_11775	1.446e-11	66.0	COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,1INTU@117747|Sphingobacteriia	976|Bacteroidetes	J	PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
MMS1_k127_262482_2	403833.Pmob_0062	8.295e-100	333.0	COG4658@1|root,COG4658@2|Bacteria,2GC98@200918|Thermotogae	200918|Thermotogae	C	Belongs to the NqrB RnfD family	-	-	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
MMS1_k127_262482_6	403833.Pmob_0063	2.387e-46	174.0	COG2869@1|root,COG2869@2|Bacteria,2GCZN@200918|Thermotogae	200918|Thermotogae	C	PFAM FMN-binding domain	-	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
MMS1_k127_262482_4	665571.STHERM_c03140	2.972e-89	298.0	COG1347@1|root,COG1347@2|Bacteria,2J9XJ@203691|Spirochaetes	203691|Spirochaetes	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
MMS1_k127_262482_3	1480694.DC28_05180	8.091e-91	302.0	COG2209@1|root,COG2209@2|Bacteria,2J9VZ@203691|Spirochaetes	203691|Spirochaetes	U	Rnf-Nqr subunit, membrane protein	-	-	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
MMS1_k127_262482_1	1307761.L21SP2_2188	8.467e-145	467.0	COG2871@1|root,COG2871@2|Bacteria,2J8WH@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
MMS1_k127_262482_5	665571.STHERM_c03170	1.928e-48	177.0	2B4IF@1|root,31XAC@2|Bacteria,2JAJT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_262482_0	1121403.AUCV01000001_gene736	2.111e-283	878.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,42PYN@68525|delta/epsilon subdivisions,2WS4X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS1_k127_2626707_1	1191523.MROS_2776	5.013e-17	81.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
MMS1_k127_2626707_0	1122927.KB895414_gene5406	9.653e-159	516.0	COG1653@1|root,COG1653@2|Bacteria,1TR5P@1239|Firmicutes,4HAFJ@91061|Bacilli,26S5W@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1
MMS1_k127_2627723_1	573413.Spirs_4089	4.731e-27	122.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_8
MMS1_k127_2627723_0	760011.Spico_0114	8.558e-87	295.0	COG0169@1|root,COG0169@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS1_k127_2629042_1	326298.Suden_0106	3.597e-75	263.0	COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1R4H0@1224|Proteobacteria	1224|Proteobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,NIT,PAS_9
MMS1_k127_2629042_0	56780.SYN_02583	2.773e-138	452.0	COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,42N2B@68525|delta/epsilon subdivisions,2WJS9@28221|Deltaproteobacteria,2MQ4E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
MMS1_k127_2629042_2	768706.Desor_3593	5.447e-47	180.0	COG0716@1|root,COG1145@1|root,COG0716@2|Bacteria,COG1145@2|Bacteria,1TRYM@1239|Firmicutes,247NM@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Flavodoxin_3,Flavodoxin_5
MMS1_k127_2629042_4	1122917.KB899677_gene45	9.293e-22	102.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_2629042_3	1408423.JHYA01000015_gene585	7.61e-25	112.0	COG5423@1|root,COG5423@2|Bacteria,1V8BX@1239|Firmicutes,4H4FI@909932|Negativicutes	909932|Negativicutes	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
MMS1_k127_2630076_2	889378.Spiaf_0957	1.725e-22	102.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_2630076_0	1480694.DC28_01480	2.843e-66	229.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_2632305_0	1121904.ARBP01000004_gene1127	2.026e-83	288.0	COG1407@1|root,COG1407@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
MMS1_k127_2633356_6	1121459.AQXE01000007_gene566	6.64e-23	102.0	COG0840@1|root,COG2703@1|root,COG0840@2|Bacteria,COG2703@2|Bacteria,1RBB1@1224|Proteobacteria,42RNA@68525|delta/epsilon subdivisions,2WNGN@28221|Deltaproteobacteria,2MGVG@213115|Desulfovibrionales	28221|Deltaproteobacteria	NPT	PFAM chemotaxis	-	-	-	ko:K03406,ko:K07216	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Hemerythrin,MCPsignal,PilJ
MMS1_k127_2633356_1	665571.STHERM_c17930	1.125e-116	384.0	COG1732@1|root,COG1732@2|Bacteria	2|Bacteria	M	glycine betaine transport	yehZ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0033554,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0104004	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	iE2348C_1286.E2348C_2278,iEC55989_1330.EC55989_2381,iECIAI39_1322.ECIAI39_0865,iECO103_1326.ECO103_2607,iECSE_1348.ECSE_2399	OpuAC
MMS1_k127_2633356_2	552811.Dehly_0908	2.421e-74	266.0	COG1174@1|root,COG1174@2|Bacteria,2G914@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
MMS1_k127_2633356_0	660470.Theba_2466	3.573e-120	395.0	COG1125@1|root,COG2239@1|root,COG1125@2|Bacteria,COG2239@2|Bacteria,2GC0I@200918|Thermotogae	2|Bacteria	E	Glycine betaine L-proline transport ATP binding subunit	yehX	GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337	3.6.3.32	ko:K02000,ko:K05847	ko02010,map02010	M00208,M00209	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	iECED1_1282.ECED1_2573,iEcE24377_1341.EcE24377A_2418,iPC815.YPO1198,iSB619.SA_RS12845	ABC_tran,CBS,MgtE_N,PRC
MMS1_k127_2633356_3	768066.HELO_2369	4.023e-62	224.0	COG1174@1|root,COG1174@2|Bacteria,1MX8D@1224|Proteobacteria,1RSDR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	permease	yehW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	iEC042_1314.EC042_2361,iECUMN_1333.ECUMN_2462	BPD_transp_1
MMS1_k127_2633356_5	908937.Prede_0707	2.388e-27	112.0	COG1773@1|root,COG1773@2|Bacteria	2|Bacteria	C	rubredoxin	rubR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
MMS1_k127_2633356_4	1123274.KB899423_gene1611	3.927e-36	138.0	COG0426@1|root,COG0426@2|Bacteria,2J589@203691|Spirochaetes	203691|Spirochaetes	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5,Lactamase_B
MMS1_k127_2639521_1	665571.STHERM_c14770	2.957e-62	220.0	COG3534@1|root,COG3534@2|Bacteria,2J6R9@203691|Spirochaetes	203691|Spirochaetes	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
MMS1_k127_2639521_0	1232410.KI421424_gene1698	2.252e-96	329.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
MMS1_k127_2642229_0	1089548.KI783301_gene1776	1.587e-06	62.0	COG3210@1|root,COG3507@1|root,COG4733@1|root,COG5184@1|root,COG3210@2|Bacteria,COG3507@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,1VW0A@1239|Firmicutes,4HWE6@91061|Bacilli,3WFP4@539002|Bacillales incertae sedis	2|Bacteria	DZ	S-layer homology domain	Tnr	-	3.2.1.8	ko:K01181,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	SLH
MMS1_k127_2643896_0	1123274.KB899412_gene1442	3.859e-200	639.0	COG1001@1|root,COG1001@2|Bacteria,2J5Y3@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
MMS1_k127_2643896_2	1307761.L21SP2_1839	4.753e-182	578.0	COG2252@1|root,COG2252@2|Bacteria,2J59V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Xanthine uracil vitamin C permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
MMS1_k127_2643896_3	1265505.ATUG01000002_gene2169	1.333e-155	503.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,42QHI@68525|delta/epsilon subdivisions,2WM6P@28221|Deltaproteobacteria,2MHXU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
MMS1_k127_2643896_1	1265505.ATUG01000002_gene2168	6.533e-191	610.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2MIER@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
MMS1_k127_2646824_7	744872.Spica_2300	2.606e-43	175.0	COG0785@1|root,COG0785@2|Bacteria,2JA8R@203691|Spirochaetes	203691|Spirochaetes	O	Cytochrome C biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2646824_5	573413.Spirs_2660	8.988e-95	328.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS1_k127_2646824_0	573413.Spirs_3302	3.194e-178	563.0	COG0834@1|root,COG0834@2|Bacteria,2J7H4@203691|Spirochaetes	203691|Spirochaetes	ET	PFAM Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
MMS1_k127_2646824_1	1123274.KB899406_gene1263	6.151e-174	554.0	COG4597@1|root,COG4597@2|Bacteria,2JACY@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
MMS1_k127_2646824_2	573413.Spirs_3304	1.702e-173	550.0	COG0765@1|root,COG0765@2|Bacteria,2JAED@203691|Spirochaetes	203691|Spirochaetes	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K09971	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
MMS1_k127_2646824_4	573413.Spirs_3305	1.739e-139	447.0	COG1126@1|root,COG1126@2|Bacteria,2J9M9@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type polar amino acid transport system ATPase component	-	-	-	ko:K09972	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
MMS1_k127_2646824_3	158189.SpiBuddy_0415	2.112e-156	505.0	COG2865@1|root,COG2865@2|Bacteria	2|Bacteria	-	-	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
MMS1_k127_2646824_6	1121904.ARBP01000002_gene7178	3.986e-45	179.0	COG0642@1|root,COG2205@2|Bacteria,4NN26@976|Bacteroidetes,47U6C@768503|Cytophagia	976|Bacteroidetes	T	7TM diverse intracellular signalling	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
MMS1_k127_2647580_5	237368.SCABRO_03345	6.708e-48	176.0	COG1456@1|root,COG1456@2|Bacteria,2J2CN@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,FeS
MMS1_k127_2647580_0	247490.KSU1_D0223	9.424e-144	476.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,2J2QB@203682|Planctomycetes	203682|Planctomycetes	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
MMS1_k127_2647580_4	269797.Mbar_A0201	1.091e-48	183.0	COG3640@1|root,arCOG00587@2157|Archaea,2XT61@28890|Euryarchaeota,2N9QI@224756|Methanomicrobia	224756|Methanomicrobia	D	AAA domain	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	AAA_31,CbiA
MMS1_k127_2647580_1	247490.KSU1_D0221	3.703e-94	318.0	COG2069@1|root,COG2069@2|Bacteria,2J2KV@203682|Planctomycetes	203682|Planctomycetes	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
MMS1_k127_2647580_2	574087.Acear_1299	9.486e-60	216.0	COG1410@1|root,COG1410@2|Bacteria,1VRVS@1239|Firmicutes,25EJA@186801|Clostridia	186801|Clostridia	E	PFAM dihydropteroate synthase, DHPS	acsE	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMS1_k127_2647580_6	768710.DesyoDRAFT_4437	1.813e-23	111.0	COG1456@1|root,COG1456@2|Bacteria,1UIEM@1239|Firmicutes,25EJY@186801|Clostridia,267AU@186807|Peptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
MMS1_k127_2647580_3	1279009.ADICEAN_02603	5.845e-57	209.0	COG0657@1|root,COG0657@2|Bacteria,4NM58@976|Bacteroidetes,47SS2@768503|Cytophagia	976|Bacteroidetes	I	Steryl acetyl hydrolase	-	-	3.1.1.83	ko:K01066,ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
MMS1_k127_2650403_1	1123274.KB899419_gene1990	3.697e-06	53.0	28RYI@1|root,2ZED6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2650403_0	1123274.KB899419_gene1989	6.521e-126	415.0	COG0621@1|root,COG0621@2|Bacteria,2J5GF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
MMS1_k127_2651274_8	1121904.ARBP01000002_gene6770	4.929e-14	82.0	COG2834@1|root,COG2834@2|Bacteria,4NIT5@976|Bacteroidetes	976|Bacteroidetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_2651274_1	1480694.DC28_13270	1.175e-129	448.0	COG4258@1|root,COG4258@2|Bacteria	2|Bacteria	I	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_2651274_5	1123274.KB899410_gene3513	4.458e-28	116.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,HTH_34,MarR,MarR_2
MMS1_k127_2651274_3	720554.Clocl_2722	1.656e-52	190.0	COG1014@1|root,COG1014@2|Bacteria,1TRFJ@1239|Firmicutes,24A29@186801|Clostridia,3WHD7@541000|Ruminococcaceae	186801|Clostridia	C	oxidoreductase, gamma subunit	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMS1_k127_2651274_6	903814.ELI_0278	1.979e-26	111.0	COG1144@1|root,COG1144@2|Bacteria,1VEPH@1239|Firmicutes,24S1F@186801|Clostridia	186801|Clostridia	C	oxidoreductase, delta subunit	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
MMS1_k127_2651274_0	720554.Clocl_2720	5.649e-142	460.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WIBC@541000|Ruminococcaceae	186801|Clostridia	C	ferredoxin oxidoreductase	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMS1_k127_2651274_2	720554.Clocl_2719	9.817e-121	396.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,3WHQF@541000|Ruminococcaceae	186801|Clostridia	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS1_k127_2651274_4	37659.JNLN01000001_gene1530	3.575e-38	151.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,36IAW@31979|Clostridiaceae	186801|Clostridia	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_2651274_7	1304284.L21TH_1924	2.162e-15	77.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae	186801|Clostridia	K	aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMS1_k127_2654253_0	1307761.L21SP2_2809	1.738e-128	421.0	COG3345@1|root,COG3345@2|Bacteria,2J68S@203691|Spirochaetes	203691|Spirochaetes	G	alpha-galactosidase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
MMS1_k127_265784_2	1449050.JNLE01000003_gene766	9.854e-43	158.0	COG1209@1|root,COG1209@2|Bacteria,1TPR2@1239|Firmicutes,2490F@186801|Clostridia,36FMD@31979|Clostridiaceae	186801|Clostridia	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
MMS1_k127_265784_3	665571.STHERM_c17060	2.607e-23	101.0	2EH48@1|root,33AW7@2|Bacteria,2J921@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_265784_1	373903.Hore_15680	2.137e-49	184.0	COG1073@1|root,COG1073@2|Bacteria,1V2C5@1239|Firmicutes,25EB6@186801|Clostridia	186801|Clostridia	P	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5,Rhodanese
MMS1_k127_265784_0	153721.MYP_3053	5.636e-50	194.0	COG0443@1|root,COG0443@2|Bacteria,4NHX7@976|Bacteroidetes,47M2C@768503|Cytophagia	976|Bacteroidetes	O	Hsp70 protein	-	-	-	ko:K04046	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
MMS1_k127_2660224_2	1121396.KB892902_gene2263	1.694e-51	185.0	COG3576@1|root,COG3576@2|Bacteria,1RHHE@1224|Proteobacteria,42T17@68525|delta/epsilon subdivisions,2WP3T@28221|Deltaproteobacteria,2MKBZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
MMS1_k127_2660224_1	1128398.Curi_c06830	1.046e-76	274.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,268TT@186813|unclassified Clostridiales	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS1_k127_2660224_0	1031288.AXAA01000008_gene1317	4.281e-139	450.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae	186801|Clostridia	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS1_k127_2661705_4	1121403.AUCV01000016_gene4398	1.597e-11	66.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,42SXG@68525|delta/epsilon subdivisions,2WP6Y@28221|Deltaproteobacteria,2MNMK@213118|Desulfobacterales	28221|Deltaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C,PAP2,SNARE_assoc
MMS1_k127_2661705_0	1232453.BAIF02000003_gene1370	1.883e-55	208.0	COG3835@1|root,COG3835@2|Bacteria,1UYBM@1239|Firmicutes,249BJ@186801|Clostridia,26BED@186813|unclassified Clostridiales	186801|Clostridia	KT	Putative sugar diacid recognition	-	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	Diacid_rec,HTH_30
MMS1_k127_2661705_1	889378.Spiaf_1722	2.616e-53	200.0	COG0679@1|root,COG0679@2|Bacteria,2J8BY@203691|Spirochaetes	203691|Spirochaetes	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
MMS1_k127_2661705_2	573413.Spirs_2558	2.838e-44	163.0	COG2164@1|root,COG2164@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
MMS1_k127_2661705_3	1226322.HMPREF1545_03350	9.402e-28	114.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24DKH@186801|Clostridia,2N77F@216572|Oscillospiraceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_2661795_2	1395513.P343_13500	2.733e-56	207.0	COG0454@1|root,COG0456@2|Bacteria,1UY6B@1239|Firmicutes,4H9WT@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
MMS1_k127_2661795_3	1123073.KB899241_gene3082	1.358e-44	176.0	COG2706@1|root,COG2706@2|Bacteria,1MUKZ@1224|Proteobacteria,1RPBK@1236|Gammaproteobacteria,1X39T@135614|Xanthomonadales	135614|Xanthomonadales	G	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS1_k127_2661795_0	1121289.JHVL01000008_gene1234	1.154e-64	228.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae	186801|Clostridia	K	GntR domain protein	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
MMS1_k127_2661795_1	525897.Dbac_2256	2.366e-57	207.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,1MU6Y@1224|Proteobacteria,42M5I@68525|delta/epsilon subdivisions,2WK8Y@28221|Deltaproteobacteria,2M91E@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8
MMS1_k127_2670607_4	573413.Spirs_1871	1.192e-36	141.0	COG0541@1|root,COG0541@2|Bacteria,2J5MF@203691|Spirochaetes	203691|Spirochaetes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS1_k127_2670607_5	1480694.DC28_01870	1.958e-33	131.0	COG0228@1|root,COG0228@2|Bacteria,2J8AD@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
MMS1_k127_2670607_6	1123274.KB899415_gene2482	2.903e-33	129.0	COG1837@1|root,COG1837@2|Bacteria,2J92T@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the UPF0109 family	yhbY	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
MMS1_k127_2670607_3	665571.STHERM_c10550	1.506e-38	152.0	COG0806@1|root,COG0806@2|Bacteria,2J73Y@203691|Spirochaetes	203691|Spirochaetes	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
MMS1_k127_2670607_0	1123274.KB899415_gene2484	6.867e-101	334.0	COG0336@1|root,COG0336@2|Bacteria,2J5KR@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
MMS1_k127_2670607_2	158190.SpiGrapes_0495	9.301e-50	179.0	COG0335@1|root,COG0335@2|Bacteria,2J825@203691|Spirochaetes	203691|Spirochaetes	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
MMS1_k127_2670607_1	545695.TREAZ_2472	3.241e-98	333.0	COG2206@1|root,COG2206@2|Bacteria,2J6GF@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
MMS1_k127_2670607_7	545694.TREPR_3161	2.525e-21	96.0	COG0792@1|root,COG0792@2|Bacteria,2J8CV@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
MMS1_k127_2672500_0	243090.RB5776	1.367e-59	218.0	COG0673@1|root,COG0673@2|Bacteria,2J216@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_2680522_5	1121289.JHVL01000005_gene1036	9.08e-45	162.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia,36FWB@31979|Clostridiaceae	186801|Clostridia	S	Dihydrodipicolinate reductase, N-terminus	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
MMS1_k127_2680522_6	1121289.JHVL01000005_gene1035	3.864e-40	151.0	2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia,36KEX@31979|Clostridiaceae	186801|Clostridia	-	-	ortA	GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	2.3.1.263	ko:K21399	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS1_k127_2680522_1	865861.AZSU01000003_gene1921	1.459e-222	698.0	COG0031@1|root,COG0031@2|Bacteria,1UI2J@1239|Firmicutes,25EB5@186801|Clostridia,36UJ3@31979|Clostridiaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.3.1.263	ko:K21400	-	-	-	-	ko00000,ko01000	-	-	-	PALP
MMS1_k127_2680522_4	865861.AZSU01000003_gene1920	1.45e-45	167.0	2DMJP@1|root,32S0N@2|Bacteria,1V766@1239|Firmicutes,24K8E@186801|Clostridia,36K7I@31979|Clostridiaceae	186801|Clostridia	S	D-ornithine 4,5-aminomutase alpha-subunit	oraS	-	5.4.3.5	ko:K17899	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	OAM_alpha
MMS1_k127_2680522_0	865861.AZSU01000003_gene1919	0.0	1182.0	COG5012@1|root,COG5012@2|Bacteria,1UHX7@1239|Firmicutes,25E66@186801|Clostridia,36GMH@31979|Clostridiaceae	186801|Clostridia	S	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	oraE	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
MMS1_k127_2680522_2	1304284.L21TH_0534	2.957e-166	532.0	COG0145@1|root,COG0145@2|Bacteria,1UK65@1239|Firmicutes,25FMC@186801|Clostridia,36V63@31979|Clostridiaceae	186801|Clostridia	EQ	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
MMS1_k127_2680522_7	1140002.I570_00703	9.963e-07	51.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,4I8J9@91061|Bacilli,4B2RG@81852|Enterococcaceae	91061|Bacilli	D	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
MMS1_k127_2680522_3	1307761.L21SP2_1019	7.78e-147	481.0	COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,2JA1N@203691|Spirochaetes	203691|Spirochaetes	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
MMS1_k127_2691529_1	698758.AXY_17970	1.255e-89	298.0	COG5297@1|root,COG5297@2|Bacteria,1UMTG@1239|Firmicutes,4ITZS@91061|Bacilli	91061|Bacilli	G	Protein of unknown function (DUF1593)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1593
MMS1_k127_2691529_0	1226325.HMPREF1548_03315	2.262e-270	850.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia	186801|Clostridia	G	hydrolase, family 3	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2691529_2	1158601.I585_00187	3.132e-16	78.0	COG0346@1|root,COG0346@2|Bacteria,1V235@1239|Firmicutes,4ICQE@91061|Bacilli,4B3EM@81852|Enterococcaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS1_k127_2694001_2	545695.TREAZ_2381	2.598e-59	223.0	COG0457@1|root,COG0457@2|Bacteria,2J8BT@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
MMS1_k127_2694001_1	573413.Spirs_2612	1.173e-130	423.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS1_k127_2694001_0	1123274.KB899419_gene1876	4.348e-153	501.0	COG1472@1|root,COG1472@2|Bacteria,2J5CS@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
MMS1_k127_2694001_3	573413.Spirs_2614	8.592e-08	59.0	COG3393@1|root,COG3393@2|Bacteria,2J84J@203691|Spirochaetes	203691|Spirochaetes	S	Acetyltransferase GNAT family	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_10,FR47
MMS1_k127_269597_1	717231.Flexsi_1986	7.685e-111	383.0	COG1022@1|root,COG1022@2|Bacteria,2GETY@200930|Deferribacteres	200930|Deferribacteres	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
MMS1_k127_269597_0	573413.Spirs_3200	4.144e-131	456.0	COG1196@1|root,COG1196@2|Bacteria,2J5RV@203691|Spirochaetes	203691|Spirochaetes	D	PFAM secretion protein HlyD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Apolipoprotein,HTH_38
MMS1_k127_2696631_0	658088.HMPREF0987_02568	6.393e-173	550.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,27J28@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Glycosyl hydrolase family 3 C-terminal domain	bglB	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2696631_1	500632.CLONEX_03122	9.615e-40	153.0	COG0789@1|root,COG0789@2|Bacteria,1V3QI@1239|Firmicutes,25B3D@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
MMS1_k127_2696766_3	545694.TREPR_0450	1.63e-128	420.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
MMS1_k127_2696766_7	1499968.TCA2_0498	1.045e-44	180.0	COG0737@1|root,COG0737@2|Bacteria,1TQCW@1239|Firmicutes,4HAUC@91061|Bacilli,26TF3@186822|Paenibacillaceae	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	yunD	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
MMS1_k127_2696766_4	1307761.L21SP2_0129	2.13e-122	404.0	COG0111@1|root,COG0111@2|Bacteria,2J6NN@203691|Spirochaetes	203691|Spirochaetes	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_2696766_0	573413.Spirs_0312	2.129e-265	828.0	COG0173@1|root,COG0173@2|Bacteria,2J5KG@203691|Spirochaetes	203691|Spirochaetes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
MMS1_k127_2696766_6	522772.Dacet_2905	2.762e-58	213.0	COG4866@1|root,COG4866@2|Bacteria,2GF8M@200930|Deferribacteres	200930|Deferribacteres	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
MMS1_k127_2696766_5	398512.JQKC01000001_gene2133	5.093e-62	219.0	COG0500@1|root,COG2226@2|Bacteria,1V3ZN@1239|Firmicutes,24HME@186801|Clostridia,3WJ6C@541000|Ruminococcaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_2696766_1	425400.LS65_02705	4.747e-162	519.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2YM81@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Cysteine desulfurase	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMS1_k127_2696766_2	1242969.ATCC51562_106	5.565e-133	430.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2YMXY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	iscU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
MMS1_k127_2696766_8	573413.Spirs_0284	9.488e-32	128.0	COG1253@1|root,COG1253@2|Bacteria,2J7S9@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
MMS1_k127_2697045_1	158190.SpiGrapes_1545	2.061e-81	275.0	COG0395@1|root,COG0395@2|Bacteria,2J7XG@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K17243	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	BPD_transp_1
MMS1_k127_2697045_0	744872.Spica_0621	1.191e-102	341.0	COG1175@1|root,COG1175@2|Bacteria,2J5Q4@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10118,ko:K17242	ko02010,map02010	M00196,M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28,3.A.1.1.39	-	-	BPD_transp_1
MMS1_k127_2697045_2	744872.Spica_0620	4.299e-23	102.0	COG1653@1|root,COG1653@2|Bacteria,2J682@203691|Spirochaetes	203691|Spirochaetes	G	extracellular solute-binding	-	-	-	ko:K02027,ko:K17241	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_269779_2	754476.Q7A_1425	0.0001147	45.0	COG0438@1|root,COG0438@2|Bacteria,1PGR8@1224|Proteobacteria,1RXHT@1236|Gammaproteobacteria,4639C@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS1_k127_269779_0	402777.KB235903_gene1044	9.075e-102	342.0	COG1215@1|root,COG1215@2|Bacteria,1GQPQ@1117|Cyanobacteria,1H9XR@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
MMS1_k127_269779_1	179408.Osc7112_4438	1.987e-77	261.0	COG1045@1|root,COG1045@2|Bacteria,1G2II@1117|Cyanobacteria,1H8WT@1150|Oscillatoriales	1117|Cyanobacteria	E	serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
MMS1_k127_2703093_0	665571.STHERM_c07710	7.806e-87	304.0	COG1345@1|root,COG1345@2|Bacteria,2J6CW@203691|Spirochaetes	203691|Spirochaetes	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliD_C,FliD_N
MMS1_k127_2706267_0	1449050.JNLE01000003_gene2005	1.963e-176	569.0	COG3408@1|root,COG3408@2|Bacteria,1UDA2@1239|Firmicutes,24A9K@186801|Clostridia,36QSF@31979|Clostridiaceae	186801|Clostridia	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_2706267_1	1226325.HMPREF1548_02387	7.65e-150	490.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYH7@1239|Firmicutes,249E3@186801|Clostridia,36GAE@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_2706267_3	1226325.HMPREF1548_02388	2.49e-122	398.0	COG0395@1|root,COG0395@2|Bacteria,1TPHS@1239|Firmicutes,24AJG@186801|Clostridia,36EG2@31979|Clostridiaceae	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_2706267_2	658086.HMPREF0994_05639	2.687e-126	410.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia,27JEE@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_2706383_5	1123274.KB899413_gene867	2.343e-37	148.0	COG1589@1|root,COG1589@2|Bacteria,2J70E@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
MMS1_k127_2706383_0	1123274.KB899413_gene866	3.707e-154	497.0	COG0849@1|root,COG0849@2|Bacteria,2J5UK@203691|Spirochaetes	203691|Spirochaetes	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
MMS1_k127_2706383_1	744872.Spica_1681	9.787e-141	457.0	COG0206@1|root,COG0206@2|Bacteria,2J5EQ@203691|Spirochaetes	203691|Spirochaetes	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS1_k127_2706383_2	1480694.DC28_02275	4.171e-98	328.0	COG4974@1|root,COG4974@2|Bacteria,2J7GT@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMS1_k127_2706383_6	869209.Tresu_1590	4.321e-27	120.0	COG0457@1|root,COG0457@2|Bacteria,2J7BD@203691|Spirochaetes	203691|Spirochaetes	S	TPR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_6,TPR_8
MMS1_k127_2706383_3	596324.TREVI0001_0398	5.169e-65	235.0	COG0758@1|root,COG0758@2|Bacteria,2J6UM@203691|Spirochaetes	203691|Spirochaetes	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
MMS1_k127_2706383_4	665571.STHERM_c09040	8.927e-50	189.0	COG4974@1|root,COG4974@2|Bacteria,2J5UZ@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMS1_k127_2706817_1	941824.TCEL_00481	5.547e-74	254.0	COG0436@1|root,COG0436@2|Bacteria,1TRA9@1239|Firmicutes,249X4@186801|Clostridia,36GQW@31979|Clostridiaceae	186801|Clostridia	E	Alanine-glyoxylate amino-transferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_2706817_0	1307761.L21SP2_0395	6.85e-77	269.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
MMS1_k127_2706817_2	1121403.AUCV01000013_gene3925	2.753e-58	211.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,42PMZ@68525|delta/epsilon subdivisions,2WMF7@28221|Deltaproteobacteria,2MJ13@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
MMS1_k127_2706817_3	1121403.AUCV01000013_gene3924	8.925e-47	171.0	COG1148@1|root,COG1148@2|Bacteria,1NZF6@1224|Proteobacteria,430SV@68525|delta/epsilon subdivisions,2WVQS@28221|Deltaproteobacteria,2MNRW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NIL	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
MMS1_k127_2706817_4	309799.DICTH_0569	1.204e-06	51.0	COG1900@1|root,COG1900@2|Bacteria	2|Bacteria	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
MMS1_k127_2711436_0	1499967.BAYZ01000009_gene5391	9.55e-233	742.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA_PrkA,PrkA
MMS1_k127_2711765_2	1122130.AUHN01000009_gene656	1.211e-86	292.0	COG1472@1|root,COG1472@2|Bacteria,2GQQR@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolase family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2711765_1	1168034.FH5T_04370	1.154e-120	403.0	COG0657@1|root,COG0657@2|Bacteria,4NKCZ@976|Bacteroidetes	976|Bacteroidetes	I	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
MMS1_k127_2711765_0	478749.BRYFOR_07057	2.914e-215	677.0	COG3534@1|root,COG3534@2|Bacteria,1TPJ0@1239|Firmicutes,25EH6@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
MMS1_k127_2717803_9	1319815.HMPREF0202_00718	8.401e-09	60.0	COG1309@1|root,COG1309@2|Bacteria,37AV5@32066|Fusobacteria	32066|Fusobacteria	K	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
MMS1_k127_2717803_4	158189.SpiBuddy_0672	2.595e-72	255.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
MMS1_k127_2717803_1	1121918.ARWE01000001_gene3106	7.457e-216	698.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,42N7P@68525|delta/epsilon subdivisions,2WMCJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
MMS1_k127_2717803_3	1121451.DESAM_22867	2.821e-118	399.0	COG2202@1|root,COG2984@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WKCD@28221|Deltaproteobacteria,2M8VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,PocR,sCache_2
MMS1_k127_2717803_0	767817.Desgi_2880	0.0	1350.0	COG1201@1|root,COG1201@2|Bacteria,1UHYQ@1239|Firmicutes,25E79@186801|Clostridia,263PU@186807|Peptococcaceae	186801|Clostridia	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS1_k127_2717803_5	5722.XP_001582824.1	1.407e-29	132.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	ko:K15502,ko:K15503	-	-	-	-	ko00000,ko01009,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5,DUF3447
MMS1_k127_2717803_2	1121918.ARWE01000001_gene751	8.859e-146	468.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS1_k127_2717803_7	795666.MW7_1313	1.45e-14	75.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,1K10F@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS1_k127_2717803_6	1270193.JARP01000006_gene1674	9.953e-23	102.0	COG3119@1|root,COG3119@2|Bacteria,4NEPB@976|Bacteroidetes,1HYHN@117743|Flavobacteriia,2NVGY@237|Flavobacterium	976|Bacteroidetes	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS1_k127_2722849_2	1047013.AQSP01000094_gene25	4.322e-07	59.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	tgl	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
MMS1_k127_2722849_1	1304888.ATWF01000002_gene59	8.648e-14	85.0	COG1404@1|root,COG5184@1|root,COG1404@2|Bacteria,COG5184@2|Bacteria,2GGNW@200930|Deferribacteres	200930|Deferribacteres	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMS1_k127_2722849_0	573413.Spirs_3971	1.101e-210	659.0	COG0673@1|root,COG0673@2|Bacteria,2J6QZ@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
MMS1_k127_2724479_0	521045.Kole_0588	2.459e-60	216.0	COG1363@1|root,COG1363@2|Bacteria,2GCQ0@200918|Thermotogae	200918|Thermotogae	C	PFAM peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
MMS1_k127_2724479_1	1414720.CBYM010000001_gene881	1.132e-29	120.0	COG1363@1|root,COG1363@2|Bacteria,1TQ86@1239|Firmicutes,25CDF@186801|Clostridia,36DEF@31979|Clostridiaceae	186801|Clostridia	G	PFAM peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
MMS1_k127_2724504_3	889378.Spiaf_1094	3.022e-37	152.0	28SPJ@1|root,2ZEZR@2|Bacteria,2JB08@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2724504_1	237368.SCABRO_03369	2.537e-57	216.0	COG0038@1|root,COG0038@2|Bacteria	2|Bacteria	P	chloride channel	clcB	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS1_k127_2724504_4	906968.Trebr_0988	7.341e-24	103.0	2FK3B@1|root,34BRF@2|Bacteria,2J8AH@203691|Spirochaetes	203691|Spirochaetes	S	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
MMS1_k127_2724504_0	665571.STHERM_c12470	3.555e-146	470.0	COG1186@1|root,COG1186@2|Bacteria,2J5QR@203691|Spirochaetes	203691|Spirochaetes	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
MMS1_k127_2724504_2	573413.Spirs_1919	6.992e-40	151.0	COG2201@1|root,COG2201@2|Bacteria	2|Bacteria	NT	protein-glutamate methylesterase activity	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
MMS1_k127_2724504_5	665571.STHERM_c12460	1.277e-06	60.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,CBM9_1,CarboxypepD_reg,DUF11,DUF4384,NPCBM_assoc,PA14,PEGA
MMS1_k127_2731648_0	933262.AXAM01000003_gene2808	1.868e-96	334.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578,ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
MMS1_k127_2731648_1	1120953.AUBH01000002_gene1522	5.082e-68	252.0	COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,466MR@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_2731648_2	748449.Halha_2075	2.277e-23	104.0	COG2996@1|root,COG2996@2|Bacteria,1TQ1Z@1239|Firmicutes,2498C@186801|Clostridia,3WBRI@53433|Halanaerobiales	186801|Clostridia	S	Ribosomal protein S1-like RNA-binding domain	cvfB	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1,S1_2
MMS1_k127_2732649_1	431943.CKL_2326	1.622e-41	163.0	COG1145@1|root,COG1145@2|Bacteria,1UI80@1239|Firmicutes,25EEM@186801|Clostridia,36UN6@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_2732649_0	1319815.HMPREF0202_02010	1.407e-146	474.0	COG1929@1|root,COG1929@2|Bacteria,379HN@32066|Fusobacteria	32066|Fusobacteria	G	Belongs to the glycerate kinase type-1 family	-	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
MMS1_k127_2733551_0	889378.Spiaf_2471	2.689e-102	346.0	COG1574@1|root,COG1574@2|Bacteria,2J7D4@203691|Spirochaetes	203691|Spirochaetes	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
MMS1_k127_2733551_1	1536775.H70737_25955	1.165e-11	78.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HGB5@91061|Bacilli,26RSX@186822|Paenibacillaceae	91061|Bacilli	T	Heme response regulator HssR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_2736122_1	1123274.KB899409_gene428	1.212e-24	106.0	COG0457@1|root,COG0457@2|Bacteria,2J7IN@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
MMS1_k127_2736122_0	744872.Spica_1151	5.632e-107	366.0	COG0621@1|root,COG0621@2|Bacteria,2J5SB@203691|Spirochaetes	203691|Spirochaetes	J	Radical SAM methylthiotransferase, MiaB RimO family	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
MMS1_k127_2736122_2	573413.Spirs_1518	3.23e-05	51.0	2DRY6@1|root,33DN5@2|Bacteria,2JB74@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2736846_3	1121335.Clst_2002	3.023e-26	116.0	COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia,3WRHJ@541000|Ruminococcaceae	186801|Clostridia	K	HAD-hyrolase-like	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_2736846_0	614083.AWQR01000009_gene534	9.519e-171	543.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2VNI2@28216|Betaproteobacteria,4A9Y0@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_2736846_1	1396418.BATQ01000106_gene5353	2.108e-161	521.0	28HX6@1|root,2Z82X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2736846_2	760011.Spico_1552	1.523e-38	151.0	COG2081@1|root,COG2081@2|Bacteria,2J83X@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM flavoprotein, HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
MMS1_k127_2741343_2	1232437.KL661963_gene3387	1.183e-59	214.0	COG2197@1|root,COG2203@1|root,COG2197@2|Bacteria,COG2203@2|Bacteria,1Q9SD@1224|Proteobacteria,42NUX@68525|delta/epsilon subdivisions,2WM09@28221|Deltaproteobacteria,2MJ9D@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
MMS1_k127_2741343_4	1396418.BATQ01000168_gene1827	5.418e-49	189.0	COG0523@1|root,COG0523@2|Bacteria,46URF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SRP54-type protein, GTPase domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
MMS1_k127_2741343_3	1304880.JAGB01000002_gene1909	7.411e-51	194.0	COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia	186801|Clostridia	K	CobW P47K family protein	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
MMS1_k127_2741343_0	373903.Hore_15330	5.768e-175	559.0	COG0407@1|root,COG0526@1|root,COG0407@2|Bacteria,COG0526@2|Bacteria,1UYXW@1239|Firmicutes,25DH8@186801|Clostridia,3WAYR@53433|Halanaerobiales	186801|Clostridia	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	Thioredoxin_3,URO-D
MMS1_k127_2741343_1	720554.Clocl_0781	3.416e-117	390.0	COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,1U23Q@1239|Firmicutes,24CZ9@186801|Clostridia,3WIZZ@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_18,HTH_AraC,PocR
MMS1_k127_2741343_5	1232453.BAIF02000062_gene1859	3.02e-48	177.0	COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
MMS1_k127_2742741_8	243231.GSU1614	5.206e-21	99.0	COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2X9YF@28221|Deltaproteobacteria,43V09@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
MMS1_k127_2742741_1	595460.RRSWK_03299	4.396e-175	559.0	COG1282@1|root,COG1282@2|Bacteria,2IYIA@203682|Planctomycetes	203682|Planctomycetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
MMS1_k127_2742741_7	1004785.AMBLS11_17835	6.459e-35	135.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,1S9UK@1236|Gammaproteobacteria,4682B@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	NAD NADP transhydrogenase alpha subunit	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
MMS1_k127_2742741_4	497964.CfE428DRAFT_1191	5.088e-123	404.0	COG3288@1|root,COG3288@2|Bacteria,46SFW@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
MMS1_k127_2742741_5	118168.MC7420_6076	3.362e-119	387.0	COG0647@1|root,COG0647@2|Bacteria,1GCWQ@1117|Cyanobacteria,1HEEW@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the HAD-like hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
MMS1_k127_2742741_9	573413.Spirs_3139	9.512e-08	63.0	2BVQY@1|root,2ZNAN@2|Bacteria,2JAY1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2742741_6	1279009.ADICEAN_00119	1.556e-72	256.0	COG0524@1|root,COG0524@2|Bacteria,4NGFK@976|Bacteroidetes,47VAC@768503|Cytophagia	976|Bacteroidetes	G	pfkB family carbohydrate kinase	ydjH_1	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS1_k127_2742741_3	998088.B565_0761	4.584e-173	548.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1Y462@135624|Aeromonadales	135624|Aeromonadales	G	aldolase	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
MMS1_k127_2742741_0	573413.Spirs_4110	2.059e-201	643.0	COG1132@1|root,COG1132@2|Bacteria,2J5E3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2742741_2	573413.Spirs_4111	4.84e-174	566.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2742804_0	573413.Spirs_2009	1.307e-53	192.0	COG0691@1|root,COG0691@2|Bacteria,2J78Q@203691|Spirochaetes	203691|Spirochaetes	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
MMS1_k127_2742804_2	596324.TREVI0001_1907	3.128e-43	168.0	COG0681@1|root,COG0681@2|Bacteria,2J7DH@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB_1	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
MMS1_k127_2742804_1	1231377.C426_1194	7.239e-51	190.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4HA60@91061|Bacilli,1YB8F@1357|Lactococcus	91061|Bacilli	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
MMS1_k127_2745747_3	411902.CLOBOL_07057	1.543e-72	256.0	COG3250@1|root,COG3250@2|Bacteria,1W77V@1239|Firmicutes,25J0P@186801|Clostridia,222YU@1506553|Lachnoclostridium	186801|Clostridia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
MMS1_k127_2745747_1	665956.HMPREF1032_01204	3.751e-100	336.0	COG0395@1|root,COG0395@2|Bacteria,1TSU8@1239|Firmicutes,24CJQ@186801|Clostridia,3WN2R@541000|Ruminococcaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_2745747_0	665956.HMPREF1032_01203	1.038e-105	352.0	COG1175@1|root,COG1175@2|Bacteria,1UZPG@1239|Firmicutes,249YU@186801|Clostridia,3WNWI@541000|Ruminococcaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_2745747_2	665956.HMPREF1032_01200	3.851e-98	329.0	COG1653@1|root,COG1653@2|Bacteria,1TT43@1239|Firmicutes,24E31@186801|Clostridia,3WRSU@541000|Ruminococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_2750586_0	326423.RBAM_032060	4.922e-75	261.0	COG1132@1|root,COG1132@2|Bacteria,1TSY4@1239|Firmicutes,4HAJQ@91061|Bacilli,1ZCBG@1386|Bacillus	91061|Bacilli	V	ABC transporter	lmrA	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702	3.6.3.44	ko:K02021,ko:K18104	ko01501,ko02010,map01501,map02010	M00700	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.123,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2750586_3	1487923.DP73_17405	3.121e-51	194.0	COG1595@1|root,COG1595@2|Bacteria,1TSCX@1239|Firmicutes,24CVD@186801|Clostridia,265HS@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
MMS1_k127_2750586_2	1499967.BAYZ01000188_gene3884	9.552e-55	196.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
MMS1_k127_2750586_4	526218.Sterm_0525	1.064e-25	111.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	yhfA	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
MMS1_k127_2750586_1	292564.Cyagr_0222	2.335e-67	259.0	2BWQ7@1|root,33XD9@2|Bacteria,1GDXX@1117|Cyanobacteria,22RVZ@167375|Cyanobium	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2750586_5	398512.JQKC01000008_gene824	1.056e-13	72.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,3WHQS@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator, GntR family	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
MMS1_k127_2753840_0	1123274.KB899414_gene3753	1.564e-191	610.0	COG1132@1|root,COG1132@2|Bacteria,2J5W8@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS1_k127_2753840_1	177437.HRM2_40990	4.3e-107	353.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2MIF2@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
MMS1_k127_2753840_5	877418.ATWV01000002_gene1076	9.871e-52	207.0	COG0840@1|root,COG0840@2|Bacteria,2JAF6@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_2753840_2	1121947.AUHK01000001_gene722	1.361e-84	291.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,22GEB@1570339|Peptoniphilaceae	186801|Clostridia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
MMS1_k127_2753840_4	243231.GSU2387	3.474e-61	218.0	COG5012@1|root,COG5012@2|Bacteria,1RBM2@1224|Proteobacteria,42QTX@68525|delta/epsilon subdivisions,2WMRE@28221|Deltaproteobacteria,43VQ0@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	B12 binding domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
MMS1_k127_2753840_3	644968.DFW101_1547	4.66e-68	242.0	COG0407@1|root,COG0407@2|Bacteria,1R8VY@1224|Proteobacteria,42QM1@68525|delta/epsilon subdivisions,2WMMS@28221|Deltaproteobacteria,2MBBK@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
MMS1_k127_2755400_5	189425.PGRAT_06705	1.101e-25	111.0	COG2220@1|root,COG2220@2|Bacteria,1TSSV@1239|Firmicutes,4HCSS@91061|Bacilli,26U52@186822|Paenibacillaceae	91061|Bacilli	S	Zn-dependent hydrolases of the beta-lactamase fold	yddR	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
MMS1_k127_2755400_0	1280390.CBQR020000100_gene2320	3.661e-100	336.0	COG0604@1|root,COG0604@2|Bacteria,1TSWF@1239|Firmicutes,4HANV@91061|Bacilli,274FR@186822|Paenibacillaceae	91061|Bacilli	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
MMS1_k127_2755400_6	700598.Niako_2516	3.291e-11	70.0	arCOG09454@1|root,30G4A@2|Bacteria,4NPSB@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2755400_2	398512.JQKC01000027_gene3903	2.393e-68	237.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,24EY6@186801|Clostridia,3WJPF@541000|Ruminococcaceae	186801|Clostridia	Q	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2755400_7	269798.CHU_3295	0.0005102	43.0	COG0500@1|root,COG2226@2|Bacteria,4P3Q0@976|Bacteroidetes,47UWN@768503|Cytophagia	976|Bacteroidetes	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2755400_3	1408473.JHXO01000008_gene2600	4.022e-63	225.0	2EG78@1|root,339Z5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2755400_1	1210908.HSB1_29500	1.098e-78	280.0	COG1621@1|root,arCOG08134@2157|Archaea,2XUXA@28890|Euryarchaeota,23UA6@183963|Halobacteria	183963|Halobacteria	G	COG1621 Beta-fructosidases (levanase invertase)	scrB	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	DUF4960,Glyco_hydro_32C,Glyco_hydro_32N
MMS1_k127_2755400_4	316274.Haur_1152	4.046e-63	222.0	COG0395@1|root,COG0395@2|Bacteria,2G6JM@200795|Chloroflexi,37760@32061|Chloroflexia	200795|Chloroflexi	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_2760154_0	316067.Geob_1139	3.635e-06	50.0	COG0593@1|root,COG1943@1|root,COG0593@2|Bacteria,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42RDM@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	Chromosomal replication initiator, DnaA	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Bac_DnaA_C,Y1_Tnp
MMS1_k127_2767305_0	411902.CLOBOL_07057	3.732e-100	344.0	COG3250@1|root,COG3250@2|Bacteria,1W77V@1239|Firmicutes,25J0P@186801|Clostridia,222YU@1506553|Lachnoclostridium	186801|Clostridia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
MMS1_k127_2771921_0	177437.HRM2_38950	9.847e-135	445.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MPY1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
MMS1_k127_2771921_1	382464.ABSI01000009_gene3973	2.006e-125	420.0	COG0685@1|root,COG0685@2|Bacteria,46TD1@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
MMS1_k127_2771921_3	1480694.DC28_09370	1.072e-75	256.0	COG1803@1|root,COG1803@2|Bacteria,2J8X0@203691|Spirochaetes	203691|Spirochaetes	G	methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
MMS1_k127_2771921_4	744872.Spica_0276	3e-57	215.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMS1_k127_2771921_2	1265505.ATUG01000002_gene1530	8.29e-88	295.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MID@68525|delta/epsilon subdivisions,2WJYT@28221|Deltaproteobacteria,2MISG@213118|Desulfobacterales	28221|Deltaproteobacteria	EK	PFAM aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
MMS1_k127_277551_4	744872.Spica_0444	2.974e-47	174.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
MMS1_k127_277551_2	1307761.L21SP2_0622	2.475e-55	198.0	COG3012@1|root,COG3012@2|Bacteria,2J7G8@203691|Spirochaetes	203691|Spirochaetes	U	SEC-C domain protein	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
MMS1_k127_277551_0	1121405.dsmv_0513	1.063e-98	333.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2WMFU@28221|Deltaproteobacteria,2MIVK@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Phosphotransferase enzyme family	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
MMS1_k127_277551_1	517417.Cpar_1029	3.1e-72	267.0	COG0507@1|root,COG0507@2|Bacteria,1FEU3@1090|Chlorobi	1090|Chlorobi	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
MMS1_k127_277551_5	909663.KI867150_gene132	1.739e-40	169.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJ30@28221|Deltaproteobacteria,2MQZ8@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	UvrD/REP helicase N-terminal domain	recB	-	3.1.11.5,3.6.4.12	ko:K03582,ko:K16898	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS1_k127_277551_3	1049564.TevJSym_am00280	3.399e-51	205.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1J5BI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS1_k127_2776653_2	573413.Spirs_0730	4.525e-10	63.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
MMS1_k127_2776653_3	573413.Spirs_0730	3.775e-07	54.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
MMS1_k127_2776653_1	1123274.KB899432_gene2938	1.63e-23	105.0	COG1917@1|root,COG1917@2|Bacteria,2JB5G@203691|Spirochaetes	203691|Spirochaetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_2776653_0	1259795.ARJK01000002_gene253	2.051e-158	508.0	COG0021@1|root,COG0021@2|Bacteria,1VS6Q@1239|Firmicutes,24YYA@186801|Clostridia,42I0G@68295|Thermoanaerobacterales	186801|Clostridia	G	Transketolase, central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N
MMS1_k127_2777412_4	665571.STHERM_c20030	1.419e-52	190.0	COG0002@1|root,COG0002@2|Bacteria,2J637@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS1_k127_2777412_2	665571.STHERM_c20040	1.394e-68	241.0	COG0548@1|root,COG0548@2|Bacteria,2J6RN@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
MMS1_k127_2777412_1	665571.STHERM_c20050	2.099e-131	432.0	COG4992@1|root,COG4992@2|Bacteria,2J5X2@203691|Spirochaetes	203691|Spirochaetes	E	PFAM aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS1_k127_2777412_0	1480694.DC28_03485	7.621e-196	618.0	COG0137@1|root,COG0137@2|Bacteria,2J5QQ@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
MMS1_k127_2777412_3	1307761.L21SP2_3341	1.764e-68	246.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMS1_k127_2777412_5	202952.BBLI01000033_gene2349	1.84e-14	76.0	COG0583@1|root,COG0583@2|Bacteria,1MWUP@1224|Proteobacteria,1RNIC@1236|Gammaproteobacteria,3NIIV@468|Moraxellaceae	1236|Gammaproteobacteria	K	LysR substrate binding domain	argP	-	-	ko:K05596	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	HTH_1,LysR_substrate
MMS1_k127_2781038_2	1192034.CAP_1562	1.279e-22	101.0	COG4269@1|root,COG4269@2|Bacteria	2|Bacteria	T	membrane	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF898
MMS1_k127_2781038_1	1307761.L21SP2_3368	6.704e-40	151.0	2E3B3@1|root,32XJU@2|Bacteria	2|Bacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
MMS1_k127_2781038_0	1307761.L21SP2_1005	4.204e-101	344.0	COG4953@1|root,COG4953@2|Bacteria,2J606@203691|Spirochaetes	203691|Spirochaetes	M	Penicillin-binding Protein	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
MMS1_k127_2784476_0	760192.Halhy_2654	3.63e-99	327.0	COG0364@1|root,COG0364@2|Bacteria,4NE59@976|Bacteroidetes,1IQZ7@117747|Sphingobacteriia	976|Bacteroidetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
MMS1_k127_2784476_3	1123008.KB905694_gene1739	1.039e-67	238.0	COG0363@1|root,COG0363@2|Bacteria,4NGB9@976|Bacteroidetes,2FNZF@200643|Bacteroidia,22XT3@171551|Porphyromonadaceae	976|Bacteroidetes	G	6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
MMS1_k127_2784476_1	1123274.KB899418_gene2236	1.974e-95	338.0	COG0840@1|root,COG0840@2|Bacteria,2J7VQ@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp-4	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
MMS1_k127_2784476_2	1123274.KB899418_gene2236	4.902e-90	318.0	COG0840@1|root,COG0840@2|Bacteria,2J7VQ@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp-4	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
MMS1_k127_2784817_1	879305.HMPREF9290_1393	1.051e-38	148.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,22GAJ@1570339|Peptoniphilaceae	186801|Clostridia	L	DEAD2 domain protein	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
MMS1_k127_2784817_0	665571.STHERM_c02560	2.925e-98	331.0	COG2017@1|root,COG2017@2|Bacteria,2J5MM@203691|Spirochaetes	203691|Spirochaetes	G	Converts alpha-aldose to the beta-anomer	galM	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
MMS1_k127_2784817_2	293826.Amet_3108	3.546e-38	149.0	COG0599@1|root,COG0599@2|Bacteria,1VD58@1239|Firmicutes,24Q09@186801|Clostridia	186801|Clostridia	S	protein, gamma-carboxymuconolactone decarboxylase subunit like protein	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMS1_k127_2785416_0	768670.Calni_1002	1.078e-26	111.0	COG2078@1|root,COG2078@2|Bacteria,2GFGW@200930|Deferribacteres	200930|Deferribacteres	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMS1_k127_2787429_4	1249480.B649_03600	3.538e-05	47.0	COG3210@1|root,COG3210@2|Bacteria,1MXIP@1224|Proteobacteria,42NZJ@68525|delta/epsilon subdivisions,2YT09@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	haemagglutination activity domain	-	-	-	-	-	-	-	-	-	-	-	-	Glug,Haemagg_act
MMS1_k127_2787429_0	889378.Spiaf_0471	6.355e-247	777.0	COG2114@1|root,COG3850@1|root,COG2114@2|Bacteria,COG3850@2|Bacteria,2J5GP@203691|Spirochaetes	203691|Spirochaetes	T	guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
MMS1_k127_2787429_2	906968.Trebr_0025	1.486e-117	412.0	COG4254@1|root,COG4254@2|Bacteria,2J6MW@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
MMS1_k127_2787429_3	889378.Spiaf_0473	1.504e-50	194.0	293BT@1|root,2ZQUE@2|Bacteria,2J5IN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2787429_1	443254.Marpi_0461	1.195e-171	552.0	COG0018@1|root,COG0018@2|Bacteria,2GC9N@200918|Thermotogae	200918|Thermotogae	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMS1_k127_2789338_0	1128421.JAGA01000002_gene1484	1.035e-160	518.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_2789338_1	190486.XAC1207	1.795e-09	67.0	COG2207@1|root,COG2207@2|Bacteria,1NB9W@1224|Proteobacteria,1SYVA@1236|Gammaproteobacteria,1XCT0@135614|Xanthomonadales	135614|Xanthomonadales	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PAS_4
MMS1_k127_2790008_1	1219049.SP5_067_00290	1.486e-06	59.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K1BB@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	dctB	-	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
MMS1_k127_2790008_0	1123366.TH3_09410	1.486e-10	65.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2JQE0@204441|Rhodospirillales	204441|Rhodospirillales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
MMS1_k127_2790107_5	1121459.AQXE01000003_gene1112	1.569e-22	98.0	COG0642@1|root,COG2202@1|root,COG5000@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1N6GE@1224|Proteobacteria,43D2R@68525|delta/epsilon subdivisions,2WUT1@28221|Deltaproteobacteria,2M913@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS_4,PAS_9
MMS1_k127_2790107_3	573413.Spirs_1682	2.013e-37	147.0	COG2716@1|root,COG2716@2|Bacteria,2JAIX@203691|Spirochaetes	203691|Spirochaetes	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
MMS1_k127_2790107_2	1280689.AUJC01000001_gene2057	5.014e-61	219.0	COG0730@1|root,COG0730@2|Bacteria,1UY5F@1239|Firmicutes,24AJU@186801|Clostridia,36G95@31979|Clostridiaceae	186801|Clostridia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS1_k127_2790107_0	550540.Fbal_0153	5.372e-176	556.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060	ADH_N,ADH_zinc_N
MMS1_k127_2790107_1	930169.B5T_03144	3.335e-158	510.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RRI0@1236|Gammaproteobacteria,1XI9I@135619|Oceanospirillales	135619|Oceanospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2790107_6	449447.MAE_45070	0.0006856	52.0	COG5542@1|root,COG5542@2|Bacteria,1G3SR@1117|Cyanobacteria	1117|Cyanobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
MMS1_k127_2790107_4	880074.BARVI_01605	1.366e-23	102.0	COG0463@1|root,COG0463@2|Bacteria,4NGGM@976|Bacteroidetes,2FMW6@200643|Bacteroidia,22XG6@171551|Porphyromonadaceae	976|Bacteroidetes	M	Glycosyltransferase	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
MMS1_k127_2792505_1	573413.Spirs_0315	2.269e-77	264.0	COG0313@1|root,COG0313@2|Bacteria,2J5DW@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
MMS1_k127_2792505_3	1123274.KB899407_gene188	3.528e-29	119.0	2DFDU@1|root,2ZRHI@2|Bacteria,2J8SZ@203691|Spirochaetes	203691|Spirochaetes	S	factor, FlgM	-	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
MMS1_k127_2792505_5	574375.BAGA_18585	2.043e-20	104.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,4HAPA@91061|Bacilli,1ZBBG@1386|Bacillus	91061|Bacilli	C	alcohol dehydrogenase	adhB	-	1.1.1.1,1.1.1.202	ko:K00001,ko:K00086	ko00010,ko00071,ko00350,ko00561,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00561,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R02377,R03119,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS1_k127_2792505_2	573413.Spirs_0318	4.186e-63	225.0	COG0566@1|root,COG0566@2|Bacteria,2J6AD@203691|Spirochaetes	203691|Spirochaetes	J	RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
MMS1_k127_2792505_4	573413.Spirs_0319	5.276e-28	114.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	nrdH	-	-	ko:K03676,ko:K06191	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
MMS1_k127_2792505_0	573413.Spirs_0320	1.302e-137	444.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_2794777_0	1480694.DC28_11115	1.073e-61	219.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
MMS1_k127_2794777_1	1123274.KB899424_gene3005	1.956e-61	217.0	COG0457@1|root,COG0457@2|Bacteria,2J5PC@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
MMS1_k127_2796690_2	215803.DB30_0583	6.291e-34	132.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,42P3H@68525|delta/epsilon subdivisions,2WK0J@28221|Deltaproteobacteria,2YZJT@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMS1_k127_2796690_1	326298.Suden_1702	1.348e-75	266.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2YNE2@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_2796690_0	1121447.JONL01000003_gene3191	1.861e-96	331.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,42WA6@68525|delta/epsilon subdivisions,2WRYV@28221|Deltaproteobacteria,2MD0F@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,SPASM
MMS1_k127_279932_0	1274374.CBLK010000070_gene1204	6.27e-322	1015.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HB2V@91061|Bacilli,26SFU@186822|Paenibacillaceae	1239|Firmicutes	G	Alpha-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
MMS1_k127_279932_1	373903.Hore_15010	4.044e-10	64.0	COG0694@1|root,COG0694@2|Bacteria,1W2CV@1239|Firmicutes	1239|Firmicutes	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
MMS1_k127_2802547_1	933262.AXAM01000016_gene187	3.789e-29	126.0	28V7D@1|root,2ZHAI@2|Bacteria,1RA29@1224|Proteobacteria,42R9H@68525|delta/epsilon subdivisions,2WN1D@28221|Deltaproteobacteria,2MJN2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
MMS1_k127_2802547_0	177437.HRM2_32590	3.203e-147	489.0	COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,42N95@68525|delta/epsilon subdivisions,2WJ0N@28221|Deltaproteobacteria,2MIKM@213118|Desulfobacterales	28221|Deltaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
MMS1_k127_2803857_1	906968.Trebr_1495	1.907e-15	84.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW	-	-	ko:K02659,ko:K03408,ko:K03415,ko:K11524	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	CheW
MMS1_k127_2803857_0	1499967.BAYZ01000009_gene5374	1.811e-39	154.0	COG0642@1|root,COG2205@2|Bacteria	1499967.BAYZ01000009_gene5374|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2804325_1	196367.JNFG01000199_gene3491	2.364e-36	151.0	COG2202@1|root,COG3829@1|root,COG4585@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,2VJV5@28216|Betaproteobacteria,1K5TA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9
MMS1_k127_2804325_0	641491.DND132_3038	1.893e-66	253.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,439Y8@68525|delta/epsilon subdivisions,2X058@28221|Deltaproteobacteria,2MAKN@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_2806227_0	1265505.ATUG01000002_gene1813	3.045e-90	305.0	COG2207@1|root,COG2207@2|Bacteria,1MUEM@1224|Proteobacteria,42QJA@68525|delta/epsilon subdivisions,2WJXP@28221|Deltaproteobacteria,2MPXP@213118|Desulfobacterales	28221|Deltaproteobacteria	K	AraC-type transcriptional regulator N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
MMS1_k127_2806227_1	1122176.KB903540_gene112	1.033e-22	104.0	COG0597@1|root,COG0597@2|Bacteria,4NNP3@976|Bacteroidetes,1ISWW@117747|Sphingobacteriia	976|Bacteroidetes	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	-	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
MMS1_k127_2806227_2	290402.Cbei_3047	7.688e-20	93.0	COG2207@1|root,COG3664@1|root,COG2207@2|Bacteria,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,36GCA@31979|Clostridiaceae	186801|Clostridia	K	family 39	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Glyco_hydro_39,HTH_18
MMS1_k127_2806227_3	1536774.H70357_08015	4.093e-14	72.0	COG2207@1|root,COG3664@1|root,COG2207@2|Bacteria,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,4HE9D@91061|Bacilli,26U5K@186822|Paenibacillaceae	91061|Bacilli	K	Glycosyl hydrolases family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	AraC_binding,Cupin_2,Glyco_hydro_39,HTH_18
MMS1_k127_2812362_0	1499967.BAYZ01000009_gene5394	1.931e-255	793.0	COG2766@1|root,COG2766@2|Bacteria	2|Bacteria	T	protein kinase activity	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
MMS1_k127_2812362_2	1232410.KI421414_gene2923	1.169e-153	494.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,42PDK@68525|delta/epsilon subdivisions,2WJKJ@28221|Deltaproteobacteria,43SCC@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF444)	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
MMS1_k127_2812362_1	933262.AXAM01000038_gene916	4.638e-177	569.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,2MI2N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SpoVR like protein	spoVR	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
MMS1_k127_2818733_1	1307761.L21SP2_3097	3.412e-76	262.0	COG1428@1|root,COG1428@2|Bacteria,2JAVV@203691|Spirochaetes	203691|Spirochaetes	F	Deoxynucleoside kinase	dck	-	2.7.1.74	ko:K00893	ko00230,ko00240,ko01100,map00230,map00240,map01100	-	R00185,R01666	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	dNK
MMS1_k127_2818733_2	880073.Calab_1912	6.104e-61	217.0	COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMS1_k127_2818733_4	1121403.AUCV01000001_gene707	1.218e-12	74.0	28RHF@1|root,2ZDWF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2818733_0	889378.Spiaf_2492	3.083e-133	440.0	COG1554@1|root,COG1554@2|Bacteria,2J6TA@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.64,5.4.2.6	ko:K01838,ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727,R02728,R11310	RC00049,RC00408	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
MMS1_k127_282467_0	158190.SpiGrapes_2787	1.853e-261	810.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10441,ko:K10542,ko:K10548,ko:K17215	ko02010,map02010	M00212,M00214,M00216,M00221,M00593	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.5	-	-	ABC_tran
MMS1_k127_282467_3	158189.SpiBuddy_2443	1.647e-159	509.0	COG1172@1|root,COG1172@2|Bacteria,2J781@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_282467_2	158190.SpiGrapes_2789	4.793e-173	548.0	COG1172@1|root,COG1172@2|Bacteria,2J78F@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_282467_1	573413.Spirs_1120	7.832e-183	578.0	COG1373@1|root,COG1373@2|Bacteria,2J5MK@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_282467_4	573413.Spirs_3569	1.644e-36	141.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	bta	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin,TraF
MMS1_k127_282467_6	573413.Spirs_0418	6.113e-05	49.0	COG3177@1|root,COG3177@2|Bacteria,2J7GE@203691|Spirochaetes	203691|Spirochaetes	S	Fic DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
MMS1_k127_282467_5	1121396.KB893054_gene2397	1.963e-31	124.0	COG1373@1|root,COG1373@2|Bacteria,1R65E@1224|Proteobacteria,42MT1@68525|delta/epsilon subdivisions,2WMV3@28221|Deltaproteobacteria,2MJXC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14
MMS1_k127_282565_0	1313304.CALK_1969	1.075e-112	369.0	COG0777@1|root,COG0777@2|Bacteria	2|Bacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
MMS1_k127_2829205_1	1382315.JPOI01000001_gene1582	2.967e-149	478.0	COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,4HBX5@91061|Bacilli,1WFG6@129337|Geobacillus	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
MMS1_k127_2829205_0	994573.T472_0219380	8.772e-177	565.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36FU2@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_2829205_5	886293.Sinac_5801	4.969e-65	233.0	COG2207@1|root,COG2207@2|Bacteria,2J1T9@203682|Planctomycetes	203682|Planctomycetes	K	PFAM AraC-type transcriptional regulator N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	AraC_N,HTH_18
MMS1_k127_2829205_4	267377.MMP0486	2.039e-77	261.0	COG1917@1|root,arCOG03444@2157|Archaea,2XWV3@28890|Euryarchaeota,23QV2@183939|Methanococci	183939|Methanococci	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_2829205_3	86416.Clopa_2708	1.562e-101	336.0	COG0599@1|root,COG0599@2|Bacteria,1TQGP@1239|Firmicutes,24BPS@186801|Clostridia,36GUB@31979|Clostridiaceae	186801|Clostridia	S	PFAM Carboxymuconolactone decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
MMS1_k127_2829205_2	573413.Spirs_4181	3.624e-146	467.0	COG0656@1|root,COG0656@2|Bacteria,2J5XV@203691|Spirochaetes	203691|Spirochaetes	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_2831353_1	744872.Spica_0622	1.841e-17	83.0	COG0395@1|root,COG0395@2|Bacteria,2J7XG@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K17243	ko02010,map02010	M00207,M00600	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.39	-	-	BPD_transp_1
MMS1_k127_2831353_0	290402.Cbei_4655	0.0	1020.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,36HWU@31979|Clostridiaceae	186801|Clostridia	G	Domain of unknown function (DUF5110)	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
MMS1_k127_283231_4	573413.Spirs_0325	2.934e-73	261.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_283231_6	536233.CLO_1766	2.687e-69	241.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,36DI6@31979|Clostridiaceae	186801|Clostridia	K	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS1_k127_283231_9	591167.Sfla_0364	2.243e-17	83.0	COG0656@1|root,COG0656@2|Bacteria,2GJQ7@201174|Actinobacteria	201174|Actinobacteria	K	aldo keto reductase	dkgA	-	1.1.1.346	ko:K06221	-	-	R08878	RC00089	ko00000,ko01000	-	-	-	Aldo_ket_red
MMS1_k127_283231_1	1307761.L21SP2_1468	6.385e-154	504.0	COG2211@1|root,COG2211@2|Bacteria,2J6P4@203691|Spirochaetes	203691|Spirochaetes	G	transporter	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
MMS1_k127_283231_3	1307761.L21SP2_1467	8.763e-88	303.0	COG0204@1|root,COG0204@2|Bacteria,2J90V@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_283231_7	665571.STHERM_c20960	3.843e-61	234.0	COG2207@1|root,COG2207@2|Bacteria,2J6IS@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18
MMS1_k127_283231_8	293826.Amet_3785	2.846e-27	117.0	2CPN3@1|root,32SJG@2|Bacteria,1VASE@1239|Firmicutes,24KG6@186801|Clostridia,36P47@31979|Clostridiaceae	186801|Clostridia	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
MMS1_k127_283231_0	293826.Amet_3786	2.722e-215	674.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,36G8D@31979|Clostridiaceae	186801|Clostridia	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
MMS1_k127_283231_5	1408422.JHYF01000012_gene3221	1.788e-72	248.0	COG3090@1|root,COG3090@2|Bacteria,1V1US@1239|Firmicutes,24G5M@186801|Clostridia,36P79@31979|Clostridiaceae	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
MMS1_k127_283231_2	742733.HMPREF9469_02239	6.95e-135	437.0	COG1638@1|root,COG1638@2|Bacteria,1TSSW@1239|Firmicutes,24DW9@186801|Clostridia,21Z6U@1506553|Lachnoclostridium	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP,TAT_signal
MMS1_k127_28350_3	1499967.BAYZ01000062_gene6034	0.0004512	44.0	COG2703@1|root,COG2703@2|Bacteria	2|Bacteria	P	oxygen carrier activity	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
MMS1_k127_28350_0	35841.BT1A1_0889	8.181e-126	412.0	COG0463@1|root,COG0463@2|Bacteria,1VVRP@1239|Firmicutes,4HVYS@91061|Bacilli,1ZS2C@1386|Bacillus	91061|Bacilli	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_28350_2	1116375.VEJY3_22251	4.842e-09	61.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1XVI1@135623|Vibrionales	135623|Vibrionales	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_28350_1	574087.Acear_0937	8.006e-57	210.0	COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia,3WB2V@53433|Halanaerobiales	186801|Clostridia	T	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
MMS1_k127_2835529_0	1480694.DC28_09930	1.647e-62	227.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_2843422_3	760568.Desku_0115	7.329e-37	147.0	COG1120@1|root,COG1120@2|Bacteria,1V1ZY@1239|Firmicutes,24G59@186801|Clostridia,261RI@186807|Peptococcaceae	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
MMS1_k127_2843422_1	573413.Spirs_1375	1.989e-119	393.0	COG0609@1|root,COG0609@2|Bacteria,2J6AK@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
MMS1_k127_2843422_0	1123274.KB899409_gene568	1.873e-159	512.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FMN_bind,Peripla_BP_2
MMS1_k127_2843422_2	1123274.KB899409_gene569	4.24e-44	165.0	COG0500@1|root,COG2226@2|Bacteria,2J8V8@203691|Spirochaetes	203691|Spirochaetes	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_284343_3	158189.SpiBuddy_2773	1.214e-12	72.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS1_k127_284343_2	158190.SpiGrapes_2219	2.805e-52	188.0	COG1725@1|root,COG1725@2|Bacteria,2J9B8@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
MMS1_k127_284343_1	158190.SpiGrapes_2216	5.677e-139	453.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_284343_0	573413.Spirs_3823	4.383e-236	756.0	COG1674@1|root,COG1674@2|Bacteria,2J63D@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
MMS1_k127_2843483_3	352165.HMPREF7215_0048	5.631e-06	58.0	COG3276@1|root,COG3276@2|Bacteria,3TA35@508458|Synergistetes	508458|Synergistetes	J	Elongation factor SelB winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
MMS1_k127_2843483_2	744872.Spica_1482	1.546e-18	94.0	290DX@1|root,32INT@2|Bacteria,2J83J@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2843483_0	1123274.KB899424_gene3007	5.554e-112	370.0	COG1475@1|root,COG1475@2|Bacteria,2J6CV@203691|Spirochaetes	203691|Spirochaetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2843483_1	596324.TREVI0001_0554	3.202e-19	88.0	COG2129@1|root,COG2129@2|Bacteria,2J5J9@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
MMS1_k127_284396_0	1307761.L21SP2_0924	2.252e-134	441.0	COG0527@1|root,COG0527@2|Bacteria,2J6FK@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
MMS1_k127_284396_1	158190.SpiGrapes_1360	4.405e-15	83.0	COG2872@1|root,COG2872@2|Bacteria,2JBG6@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS1_k127_284515_2	1307761.L21SP2_2898	2.319e-93	313.0	COG0304@1|root,COG0304@2|Bacteria,2J5H7@203691|Spirochaetes	203691|Spirochaetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_284515_5	714943.Mucpa_5898	6.665e-36	142.0	COG2318@1|root,COG2318@2|Bacteria,4NP63@976|Bacteroidetes,1ISD5@117747|Sphingobacteriia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
MMS1_k127_284515_0	1304888.ATWF01000001_gene584	8.894e-241	751.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS1_k127_284515_1	1304888.ATWF01000001_gene583	1.988e-168	537.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS1_k127_284515_6	1280944.HY17_09205	1.229e-35	143.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria,43XHM@69657|Hyphomonadaceae	28211|Alphaproteobacteria	EH	COG0512 Anthranilate para-aminobenzoate synthases component II	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
MMS1_k127_284515_3	1443125.Z962_03170	2.049e-69	252.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,36DMY@31979|Clostridiaceae	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind
MMS1_k127_284515_4	1123274.KB899409_gene576	3.729e-59	222.0	COG2972@1|root,COG2972@2|Bacteria,2J9TH@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
MMS1_k127_2845459_4	1869.MB27_09740	5.258e-07	52.0	COG1472@1|root,COG1472@2|Bacteria,2GJ5H@201174|Actinobacteria	201174|Actinobacteria	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	F5_F8_type_C,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2845459_3	525257.HMPREF0204_13405	1.4e-25	115.0	COG2207@1|root,COG2207@2|Bacteria,4NEU2@976|Bacteroidetes,1I00W@117743|Flavobacteriia,3ZRCS@59732|Chryseobacterium	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_2845459_0	1480694.DC28_09330	2.2e-266	841.0	COG1472@1|root,COG1472@2|Bacteria,2J6UN@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2845459_2	1121859.KB890755_gene1158	3.867e-113	382.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes	976|Bacteroidetes	P	Arylsulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS1_k127_2845459_1	1304880.JAGB01000002_gene1606	2.61e-120	396.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,247Z9@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS1_k127_2848799_0	573413.Spirs_1868	2.567e-209	675.0	COG1196@1|root,COG1196@2|Bacteria,2J57J@203691|Spirochaetes	203691|Spirochaetes	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
MMS1_k127_2849571_0	1307761.L21SP2_1614	8.881e-138	447.0	COG0141@1|root,COG0141@2|Bacteria,2J5QF@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
MMS1_k127_2849571_1	1123274.KB899422_gene74	7.822e-72	252.0	COG0285@1|root,COG0285@2|Bacteria,2J5CZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM folylpolyglutamate synthase dihydrofolate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS1_k127_2852139_0	545694.TREPR_2339	1.762e-113	377.0	COG0539@1|root,COG0539@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
MMS1_k127_2852139_1	889378.Spiaf_1517	3.309e-74	256.0	COG1187@1|root,COG1187@2|Bacteria,2J5AJ@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
MMS1_k127_2852139_2	1125699.HMPREF9194_01311	1.052e-65	228.0	COG1386@1|root,COG1386@2|Bacteria,2J75V@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMS1_k127_2852139_3	889378.Spiaf_1519	5.171e-18	85.0	COG1354@1|root,COG1354@2|Bacteria,2J5RF@203691|Spirochaetes	203691|Spirochaetes	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMS1_k127_2852412_6	1385935.N836_11090	8.86e-06	48.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
MMS1_k127_2852412_0	331678.Cphamn1_1369	1.641e-95	316.0	COG0288@1|root,COG0288@2|Bacteria,1FERE@1090|Chlorobi	1090|Chlorobi	H	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
MMS1_k127_2852412_4	1033743.CAES01000002_gene1763	6.332e-38	151.0	COG0500@1|root,COG2226@2|Bacteria,1VTX9@1239|Firmicutes,4HV5M@91061|Bacilli,26WF3@186822|Paenibacillaceae	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS1_k127_2852412_2	485913.Krac_8408	8.273e-42	158.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_2852412_1	754027.HMPREF9554_02870	2.472e-54	213.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
MMS1_k127_2852412_3	268407.PWYN_16620	4.986e-40	153.0	COG3279@1|root,COG3279@2|Bacteria,1VA36@1239|Firmicutes,4HNQ6@91061|Bacilli,26XMD@186822|Paenibacillaceae	91061|Bacilli	KT	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	LytTR
MMS1_k127_2852412_7	641107.CDLVIII_5948	0.0001392	50.0	2DV62@1|root,305S2@2|Bacteria,1TYK0@1239|Firmicutes,24RXH@186801|Clostridia,36MU8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2852412_5	1280686.AUKE01000004_gene171	3.616e-06	57.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,24ERK@186801|Clostridia,4BYUY@830|Butyrivibrio	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
MMS1_k127_2855119_0	443254.Marpi_0633	4.674e-07	62.0	COG5276@1|root,COG5276@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,He_PIG,LVIVD,Laminin_G_3,Reprolysin_4,TSP_3
MMS1_k127_2862998_0	573413.Spirs_1187	4.976e-134	458.0	COG0642@1|root,COG0784@1|root,COG3292@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HATPase_c,HisKA,HisKA_3,Hpt,Reg_prop,Response_reg,Y_Y_Y
MMS1_k127_2867757_1	744872.Spica_0879	1.248e-55	203.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM,MHYT,PAS,PAS_3,PAS_4,PAS_9,dCache_1,dCache_3
MMS1_k127_2867757_0	573413.Spirs_2081	5.238e-74	256.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
MMS1_k127_2871375_0	1150474.JQJI01000022_gene666	1.126e-147	480.0	COG0446@1|root,COG0446@2|Bacteria,2GC6J@200918|Thermotogae	200918|Thermotogae	S	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS1_k127_2871375_3	1112204.GPOL_c42030	7.137e-05	51.0	COG1846@1|root,COG1846@2|Bacteria,2GTV5@201174|Actinobacteria,4GEMD@85026|Gordoniaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_2871375_2	573413.Spirs_2389	3.934e-23	102.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2,ROK,RadC
MMS1_k127_2871375_1	1414720.CBYM010000012_gene2551	4.961e-124	405.0	COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia,36F70@31979|Clostridiaceae	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_2871988_0	573413.Spirs_2850	9.502e-188	602.0	COG0243@1|root,COG0243@2|Bacteria,2J9ZG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.3	ko:K07306	ko00920,map00920	-	R09501	RC02555	ko00000,ko00001,ko01000,ko02000	5.A.3.3	-	-	Molybdopterin,Molydop_binding,Nitrate_red_del
MMS1_k127_2871988_2	1265505.ATUG01000001_gene4499	1.94e-147	486.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_2871988_1	1480694.DC28_03640	5.188e-160	516.0	COG0469@1|root,COG0469@2|Bacteria,2J5VE@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
MMS1_k127_287704_2	1121396.KB893062_gene2776	2.603e-76	261.0	COG4650@1|root,COG4650@2|Bacteria,1MX6U@1224|Proteobacteria,42NHB@68525|delta/epsilon subdivisions,2WKUB@28221|Deltaproteobacteria,2MMWE@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Regulator of RNA terminal phosphate cyclase	rtcR	-	-	ko:K14414	-	-	-	-	ko00000,ko03000	-	-	-	RtcR,Sigma54_activat
MMS1_k127_287704_1	941449.dsx2_1503	1.06e-115	380.0	COG4650@1|root,COG4650@2|Bacteria,1MX6U@1224|Proteobacteria,42NHB@68525|delta/epsilon subdivisions,2WKUB@28221|Deltaproteobacteria,2MEAN@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	Regulator of RNA terminal phosphate cyclase	rtcR	-	-	ko:K14414	-	-	-	-	ko00000,ko03000	-	-	-	RtcR,Sigma54_activat
MMS1_k127_287704_0	313606.M23134_06133	0.0	1234.0	COG1413@1|root,COG1413@2|Bacteria,4NG91@976|Bacteroidetes	976|Bacteroidetes	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
MMS1_k127_2884_0	588581.Cpap_1722	5.052e-111	368.0	COG1181@1|root,COG1181@2|Bacteria,1UJ6D@1239|Firmicutes,25EWC@186801|Clostridia	186801|Clostridia	M	Mur ligase middle domain protein	cphA	-	6.3.2.2,6.3.2.29,6.3.2.30	ko:K01919,ko:K03802	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
MMS1_k127_2884_2	765420.OSCT_0967	6.559e-55	198.0	COG1045@1|root,COG1045@2|Bacteria,2G6DI@200795|Chloroflexi,374UH@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM serine O-acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
MMS1_k127_2884_1	246194.CHY_1707	1.339e-59	209.0	COG0716@1|root,COG0716@2|Bacteria,1V465@1239|Firmicutes,24DQZ@186801|Clostridia,42FJH@68295|Thermoanaerobacterales	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
MMS1_k127_289416_6	1480694.DC28_03960	8.671e-43	170.0	2FEHN@1|root,346H5@2|Bacteria,2J8A9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_289416_12	1321815.HMPREF9193_01338	7.628e-08	59.0	28WTD@1|root,2ZISW@2|Bacteria,2J93F@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_289416_10	744872.Spica_2373	4.959e-33	132.0	COG1734@1|root,COG1734@2|Bacteria,2J7Y1@203691|Spirochaetes	203691|Spirochaetes	T	Prokaryotic dksA traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
MMS1_k127_289416_9	573413.Spirs_0463	1.274e-37	142.0	COG0361@1|root,COG0361@2|Bacteria,2J8JW@203691|Spirochaetes	203691|Spirochaetes	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
MMS1_k127_289416_11	221027.JO40_09040	4.553e-25	111.0	COG2840@1|root,COG2840@2|Bacteria,2J57A@203691|Spirochaetes	203691|Spirochaetes	S	Smr domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Smr
MMS1_k127_289416_4	1480694.DC28_03990	1.375e-57	225.0	COG0457@1|root,346MI@2|Bacteria,2JAUI@203691|Spirochaetes	203691|Spirochaetes	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
MMS1_k127_289416_8	889378.Spiaf_2532	1.02e-38	152.0	COG0457@1|root,COG0457@2|Bacteria,2J8PR@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
MMS1_k127_289416_5	1480694.DC28_04000	4.079e-48	186.0	COG2304@1|root,COG2304@2|Bacteria,2J5I2@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_2,VWA,VWA_2
MMS1_k127_289416_3	1307761.L21SP2_2835	1.448e-93	317.0	COG2304@1|root,COG2304@2|Bacteria,2J6JM@203691|Spirochaetes	203691|Spirochaetes	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
MMS1_k127_289416_2	1123274.KB899408_gene3777	1.836e-106	353.0	COG1721@1|root,COG1721@2|Bacteria,2J6XP@203691|Spirochaetes	203691|Spirochaetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_289416_0	665571.STHERM_c16810	2.997e-135	437.0	COG0714@1|root,COG0714@2|Bacteria,2J5VG@203691|Spirochaetes	203691|Spirochaetes	S	ATPase family associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_289416_1	1480694.DC28_04025	2.338e-126	418.0	COG1364@1|root,COG1364@2|Bacteria,2J5IC@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
MMS1_k127_292463_0	907348.TresaDRAFT_0534	9.128e-31	126.0	COG0643@1|root,COG0643@2|Bacteria,2J5GK@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
MMS1_k127_294454_0	595460.RRSWK_06237	4.654e-143	458.0	COG1087@1|root,COG1087@2|Bacteria,2IY22@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS1_k127_297126_1	713586.KB900536_gene423	1.6e-39	156.0	COG2199@1|root,COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,PAS_9
MMS1_k127_297126_3	765910.MARPU_10690	3.512e-23	106.0	2DD27@1|root,2ZG7S@2|Bacteria,1RCU2@1224|Proteobacteria,1S2AJ@1236|Gammaproteobacteria,1WY0D@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_297126_2	1123288.SOV_5c02340	1.168e-28	120.0	2AD7J@1|root,312WH@2|Bacteria,1V9CY@1239|Firmicutes,4H7NJ@909932|Negativicutes	909932|Negativicutes	S	Domain of unknown function (DUF1987)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1987
MMS1_k127_297126_0	1487923.DP73_18685	6.892e-60	220.0	COG2208@1|root,COG4191@1|root,COG2208@2|Bacteria,COG4191@2|Bacteria,1TWCW@1239|Firmicutes,25A37@186801|Clostridia,26428@186807|Peptococcaceae	186801|Clostridia	KT	stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE,dCache_1
MMS1_k127_29899_1	907348.TresaDRAFT_0939	3.534e-23	103.0	COG1609@1|root,COG2207@1|root,COG1609@2|Bacteria,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K02529,ko:K03604	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,GntR,HTH_18,LacI,Peripla_BP_3
MMS1_k127_29899_0	744872.Spica_2456	1.967e-210	666.0	COG3507@1|root,COG3507@2|Bacteria,2J6J0@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
MMS1_k127_29899_2	1122921.KB898186_gene4921	1.93e-20	96.0	COG1917@1|root,COG1917@2|Bacteria,1TXTP@1239|Firmicutes,4I6VZ@91061|Bacilli,26Z64@186822|Paenibacillaceae	91061|Bacilli	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_299259_1	1125725.HMPREF1325_1198	9.449e-14	76.0	COG2604@1|root,COG2604@2|Bacteria,2J5AX@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
MMS1_k127_299259_3	1307761.L21SP2_1211	0.0009685	48.0	COG2604@1|root,COG2604@2|Bacteria,2J5P0@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
MMS1_k127_299259_2	1408422.JHYF01000004_gene1665	0.0003208	52.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GGDEF,HD,PAS,Response_reg
MMS1_k127_299259_0	889378.Spiaf_1434	1.008e-14	85.0	2FFB7@1|root,3478X@2|Bacteria,2J8CB@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_300322_1	373903.Hore_01800	2.152e-64	228.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3WB8V@53433|Halanaerobiales	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
MMS1_k127_300322_2	573413.Spirs_0476	2.697e-64	224.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
MMS1_k127_300322_0	1480694.DC28_06800	1.532e-94	317.0	COG1136@1|root,COG1136@2|Bacteria,2J5PI@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_300322_3	744872.Spica_1881	3.474e-52	190.0	COG4636@1|root,COG4636@2|Bacteria,2J8R4@203691|Spirochaetes	203691|Spirochaetes	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
MMS1_k127_300322_6	869209.Tresu_1564	1.592e-07	62.0	28ZP2@1|root,2ZME7@2|Bacteria,2J94H@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_300322_4	906968.Trebr_0926	1.653e-40	153.0	COG2834@1|root,COG2834@2|Bacteria,2J5TZ@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_301510_1	573413.Spirs_2929	2.543e-40	158.0	COG1181@1|root,COG1181@2|Bacteria,2J5KK@203691|Spirochaetes	203691|Spirochaetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,ATP-grasp_4
MMS1_k127_301510_0	573413.Spirs_2928	2.861e-62	226.0	COG0860@1|root,COG0860@2|Bacteria,2J5PE@203691|Spirochaetes	203691|Spirochaetes	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Cu_amine_oxidN1
MMS1_k127_305696_1	1122983.BAJY01000020_gene1141	9.586e-12	74.0	2F6UD@1|root,33ZAH@2|Bacteria,4P45U@976|Bacteroidetes,2FYYM@200643|Bacteroidia	976|Bacteroidetes	S	SprT-like family	-	-	-	-	-	-	-	-	-	-	-	-	SprT-like
MMS1_k127_305696_0	622637.KE124774_gene1166	3.565e-93	316.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2TW3X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
MMS1_k127_306874_0	33035.JPJF01000086_gene922	5.304e-206	668.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,3XYPB@572511|Blautia	186801|Clostridia	G	Psort location Cytoplasmic, score 9.98	tvaI	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Alpha-amylase_C,Alpha-amylase_N
MMS1_k127_307078_4	1122947.FR7_1207	6.107e-06	49.0	COG4191@1|root,COG4191@2|Bacteria,1UYQH@1239|Firmicutes	1239|Firmicutes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_307078_2	1230342.CTM_15708	3.181e-12	67.0	COG4191@1|root,COG4191@2|Bacteria,1V2NQ@1239|Firmicutes,24CX8@186801|Clostridia,36E32@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
MMS1_k127_307078_0	1230342.CTM_15723	2.648e-24	115.0	COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1UDQ5@1239|Firmicutes,25AZX@186801|Clostridia,36G08@31979|Clostridiaceae	186801|Clostridia	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,Response_reg
MMS1_k127_307078_1	1304885.AUEY01000033_gene1920	3.239e-16	83.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,42R7R@68525|delta/epsilon subdivisions,2WMT0@28221|Deltaproteobacteria,2MJMX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HATPase_c,HisKA,PAS,Response_reg
MMS1_k127_308112_1	545694.TREPR_2855	1.089e-38	145.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
MMS1_k127_308112_3	889378.Spiaf_2090	1.465e-13	79.0	COG3190@1|root,COG3190@2|Bacteria,2J8HN@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
MMS1_k127_308112_0	744872.Spica_1529	5.541e-94	317.0	COG1338@1|root,COG1338@2|Bacteria,2J5S9@203691|Spirochaetes	203691|Spirochaetes	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
MMS1_k127_308112_2	665571.STHERM_c09270	1.827e-21	96.0	COG1987@1|root,COG1987@2|Bacteria,2J93G@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
MMS1_k127_308112_4	573413.Spirs_1580	1.536e-06	51.0	COG1684@1|root,COG1684@2|Bacteria,2J6DD@203691|Spirochaetes	203691|Spirochaetes	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
MMS1_k127_310653_1	1307761.L21SP2_2117	5.356e-104	341.0	COG0568@1|root,COG0568@2|Bacteria,2J71G@203691|Spirochaetes	203691|Spirochaetes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_310653_2	1265505.ATUG01000001_gene3592	2.998e-101	341.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria,2MIH3@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glycos_transf_1
MMS1_k127_310653_0	744872.Spica_1029	2.268e-116	382.0	COG1109@1|root,COG1109@2|Bacteria,2J5QI@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	cpsG	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS1_k127_316343_5	720554.Clocl_2857	2.771e-70	256.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,3WHEV@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
MMS1_k127_316343_6	439235.Dalk_3987	2.313e-13	81.0	COG0778@1|root,COG1148@1|root,COG0778@2|Bacteria,COG1148@2|Bacteria,1NCVT@1224|Proteobacteria,42Y7G@68525|delta/epsilon subdivisions,2WUEJ@28221|Deltaproteobacteria,2MMPD@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_316343_2	744872.Spica_2026	1.3e-125	413.0	COG0539@1|root,COG0539@2|Bacteria,2J5FY@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
MMS1_k127_316343_4	1121396.KB893024_gene3907	3.336e-86	289.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2WNP9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMS1_k127_316343_1	1121396.KB893024_gene3911	6.006e-127	413.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2MKTN@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMS1_k127_316343_0	1121396.KB893024_gene3909	1.339e-160	521.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria,2MJ5H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
MMS1_k127_316343_3	1121396.KB893024_gene3908	5.298e-114	371.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MJ2V@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_317141_0	686340.Metal_0314	1.06e-46	180.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1XEXP@135618|Methylococcales	135618|Methylococcales	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
MMS1_k127_317141_1	525897.Dbac_2905	6.794e-29	123.0	COG2197@1|root,COG2197@2|Bacteria,1MXI3@1224|Proteobacteria,42WHD@68525|delta/epsilon subdivisions,2WSDG@28221|Deltaproteobacteria,2MDDQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
MMS1_k127_318116_6	1313304.CALK_1284	1.471e-32	132.0	COG1394@1|root,COG1394@2|Bacteria	2|Bacteria	C	ATPase activity, coupled to transmembrane movement of substances	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS1_k127_318116_0	1121094.KB894649_gene1312	6.973e-72	265.0	COG1269@1|root,COG1269@2|Bacteria,4NGJ9@976|Bacteroidetes,2FMC6@200643|Bacteroidia,4AKR6@815|Bacteroidaceae	976|Bacteroidetes	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS1_k127_318116_2	1313304.CALK_1282	4.894e-48	177.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS1_k127_318116_7	545694.TREPR_1145	1.181e-20	97.0	COG1762@1|root,COG1762@2|Bacteria,2J7SC@203691|Spirochaetes	203691|Spirochaetes	GT	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
MMS1_k127_318116_3	926692.AZYG01000040_gene1527	1.648e-47	179.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes	1239|Firmicutes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
MMS1_k127_318116_4	642492.Clole_2890	2.439e-47	171.0	COG0346@1|root,COG0346@2|Bacteria,1VC53@1239|Firmicutes,24ICT@186801|Clostridia	186801|Clostridia	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
MMS1_k127_318116_1	1121403.AUCV01000003_gene1666	4.506e-68	237.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	wcfH	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
MMS1_k127_318116_5	1033810.HLPCO_000740	3.611e-45	169.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS1_k127_319850_3	411902.CLOBOL_02144	4.092e-54	199.0	COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia,21YJJ@1506553|Lachnoclostridium	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	rhaB	-	2.7.1.5,2.7.1.51	ko:K00848,ko:K00879	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014,R03241	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_319850_4	392500.Swoo_0809	3.363e-41	160.0	COG0834@1|root,COG0834@2|Bacteria,1PE4A@1224|Proteobacteria,1S3KG@1236|Gammaproteobacteria,2QC42@267890|Shewanellaceae	1236|Gammaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_319850_0	1304880.JAGB01000001_gene538	4.059e-205	645.0	COG1063@1|root,COG1063@2|Bacteria,1TQ60@1239|Firmicutes,248JR@186801|Clostridia	186801|Clostridia	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_319850_1	1511.CLOST_2434	1.286e-166	539.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia	186801|Clostridia	T	Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	DUF3369,HD,HD_5,Response_reg
MMS1_k127_319850_2	1469948.JPNB01000001_gene2008	9.379e-70	243.0	COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria,1V2NQ@1239|Firmicutes,24CX8@186801|Clostridia,36E32@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
MMS1_k127_320148_4	269797.Mbar_A3306	3.692e-137	450.0	COG0477@1|root,arCOG00143@2157|Archaea,2XUTR@28890|Euryarchaeota,2N94Q@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_320148_7	1500257.JQNM01000003_gene5415	2.412e-107	355.0	COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,2U1Y8@28211|Alphaproteobacteria,4BIS4@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
MMS1_k127_320148_8	1410608.JNKX01000001_gene1672	4.617e-90	305.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	csn	-	3.2.1.132	ko:K01233	ko00520,ko01100,map00520,map01100	-	R02833	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_46
MMS1_k127_320148_5	871968.DESME_02565	1.058e-129	430.0	COG1409@1|root,COG1409@2|Bacteria,1VDYM@1239|Firmicutes,24GDB@186801|Clostridia,262VZ@186807|Peptococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
MMS1_k127_320148_1	573413.Spirs_1783	2.834e-195	614.0	COG1840@1|root,COG1840@2|Bacteria,2J600@203691|Spirochaetes	203691|Spirochaetes	P	ABC-type Fe3 transport system, periplasmic component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_8
MMS1_k127_320148_0	573413.Spirs_1784	0.0	1020.0	COG1178@1|root,COG1178@2|Bacteria,2J5J4@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
MMS1_k127_320148_2	1123274.KB899415_gene2399	8.646e-189	594.0	COG3842@1|root,COG3842@2|Bacteria,2J58Q@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010,ko:K10112	ko02010,map02010	M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10	-	-	ABC_tran,TOBE_2
MMS1_k127_320148_9	573413.Spirs_1786	2.896e-81	276.0	COG0745@1|root,COG0745@2|Bacteria,2J7CK@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07657,ko:K07658,ko:K18941	ko02020,map02020	M00434,M00716,M00717	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_320148_3	1123274.KB899415_gene2401	1.039e-142	472.0	COG5002@1|root,COG5002@2|Bacteria,2J5SU@203691|Spirochaetes	203691|Spirochaetes	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_8
MMS1_k127_320148_6	1123274.KB899415_gene2402	2.051e-128	420.0	COG1109@1|root,COG1109@2|Bacteria,2J5GY@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS1_k127_321675_4	926561.KB900617_gene1206	1.789e-09	70.0	COG0840@1|root,COG0840@2|Bacteria,1VASW@1239|Firmicutes,24NGG@186801|Clostridia,3WB4B@53433|Halanaerobiales	186801|Clostridia	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_321675_1	565034.BHWA1_00488	7.715e-43	160.0	COG0745@1|root,COG0745@2|Bacteria,2J89I@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
MMS1_k127_321675_0	926561.KB900617_gene1203	4.139e-145	483.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WB3C@53433|Halanaerobiales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric domain	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
MMS1_k127_321675_2	1387312.BAUS01000012_gene2178	2.571e-37	147.0	COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,2VJ1T@28216|Betaproteobacteria,2KKB1@206350|Nitrosomonadales	206350|Nitrosomonadales	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
MMS1_k127_321675_3	330214.NIDE2365	9.841e-26	112.0	COG1352@1|root,COG1352@2|Bacteria,3J0XI@40117|Nitrospirae	2|Bacteria	NT	Chemotaxis protein methyltransferase	cheR	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
MMS1_k127_322771_1	1286632.P278_00800	7.21e-80	271.0	COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,1HY2W@117743|Flavobacteriia	976|Bacteroidetes	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
MMS1_k127_322771_0	573413.Spirs_0492	4.669e-84	302.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_323285_0	1121405.dsmv_0428	5.267e-163	524.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MHKF@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS1_k127_323285_6	158190.SpiGrapes_2371	1.486e-23	106.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS1_k127_323285_2	1121918.ARWE01000001_gene3055	1.236e-45	174.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,43S55@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
MMS1_k127_323285_3	877418.ATWV01000002_gene1074	1.231e-42	164.0	COG3762@1|root,COG3762@2|Bacteria,2J6T4@203691|Spirochaetes	203691|Spirochaetes	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
MMS1_k127_323285_1	243275.TDE_0955	4.951e-75	258.0	COG1704@1|root,COG1704@2|Bacteria,2J65U@203691|Spirochaetes	203691|Spirochaetes	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
MMS1_k127_323285_4	2423.NA23_0207295	1.352e-39	156.0	COG1814@1|root,COG1814@2|Bacteria,2GDXP@200918|Thermotogae	200918|Thermotogae	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
MMS1_k127_323285_5	326298.Suden_0739	1.373e-27	119.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS1_k127_324121_1	665571.STHERM_c09520	3.294e-77	279.0	2EWYA@1|root,33Q9N@2|Bacteria,2J5N1@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_324121_0	665571.STHERM_c09530	5e-324	1047.0	COG2208@1|root,COG2208@2|Bacteria,2J5MN@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,SpoIIE
MMS1_k127_326716_4	1123405.AUMM01000016_gene2494	1.956e-07	54.0	COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,4H9Q0@91061|Bacilli	91061|Bacilli	T	Signal transduction histidine kinase regulating citrate malate metabolism	-	-	2.7.13.3	ko:K02476,ko:K11614	ko02020,map02020	M00490	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,PAS,SPOB_a,sCache_3_2
MMS1_k127_326716_2	1449126.JQKL01000008_gene273	1.242e-106	364.0	COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,247YE@186801|Clostridia,26AHG@186813|unclassified Clostridiales	186801|Clostridia	T	Single cache domain 3	citS	-	2.7.13.3	ko:K11691	ko02020,map02020	M00489	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,PAS,PAS_4,SPOB_a,sCache_3_2
MMS1_k127_326716_3	1122947.FR7_3774	1.737e-50	187.0	COG4565@1|root,COG4565@2|Bacteria,1V49R@1239|Firmicutes,4H72X@909932|Negativicutes	909932|Negativicutes	KT	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS1_k127_326716_0	545695.TREAZ_2725	3.129e-249	776.0	COG0281@1|root,COG0281@2|Bacteria,2J5DN@203691|Spirochaetes	203691|Spirochaetes	C	Malic enzyme, NAD binding domain	mdh	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
MMS1_k127_326716_1	941449.dsx2_0616	1.347e-165	530.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2M81W@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
MMS1_k127_326914_0	1124982.MSI_05830	2.532e-52	208.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp2	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_3_3
MMS1_k127_327541_0	180332.JTGN01000020_gene1253	5.358e-185	587.0	COG1653@1|root,COG1653@2|Bacteria,1TRMK@1239|Firmicutes,24BMJ@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027,ko:K10117	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	SBP_bac_8
MMS1_k127_327541_1	97139.C824_01462	6.349e-129	433.0	COG2972@1|root,COG2972@2|Bacteria,1TS61@1239|Firmicutes,247ZZ@186801|Clostridia,36GPR@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
MMS1_k127_327541_2	180332.JTGN01000020_gene1255	6.727e-67	239.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24FGY@186801|Clostridia	186801|Clostridia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_329021_2	1123274.KB899406_gene1182	2.082e-42	158.0	COG2202@1|root,COG3437@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,2JBG1@203691|Spirochaetes	203691|Spirochaetes	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD,PAS_3,PAS_9
MMS1_k127_329021_0	1123274.KB899408_gene3813	5.994e-66	247.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_329021_1	351348.Maqu_3846	1.38e-48	188.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1T44N@1236|Gammaproteobacteria,46D75@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_330220_2	742725.HMPREF9450_01609	8.73e-46	173.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,4P295@976|Bacteroidetes,2G1PF@200643|Bacteroidia,22U63@171550|Rikenellaceae	976|Bacteroidetes	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
MMS1_k127_330220_0	1150600.ADIARSV_0900	2.524e-94	326.0	COG0651@1|root,COG0651@2|Bacteria,4P1B6@976|Bacteroidetes	976|Bacteroidetes	CP	Proton-conducting membrane transporter	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
MMS1_k127_330220_3	1433126.BN938_1563	5.115e-28	122.0	COG4237@1|root,COG4237@2|Bacteria,4P642@976|Bacteroidetes,2G25J@200643|Bacteroidia,22UED@171550|Rikenellaceae	976|Bacteroidetes	C	Hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS1_k127_330220_1	1150600.ADIARSV_0898	5.96e-79	273.0	COG0650@1|root,COG0650@2|Bacteria,4P2YM@976|Bacteroidetes	976|Bacteroidetes	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
MMS1_k127_330336_4	1340434.AXVA01000011_gene3202	1.151e-40	158.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,4HI6C@91061|Bacilli,1ZDPW@1386|Bacillus	91061|Bacilli	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
MMS1_k127_330336_1	926560.KE387025_gene4044	1.396e-99	334.0	2C1EG@1|root,2Z7MZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_330336_2	1111479.AXAR01000019_gene1330	6.907e-49	183.0	COG1280@1|root,COG1280@2|Bacteria,1TSNA@1239|Firmicutes,4HGU9@91061|Bacilli	91061|Bacilli	E	Transporter LysE	lysE1	-	-	-	-	-	-	-	-	-	-	-	LysE
MMS1_k127_330336_5	525257.HMPREF0204_14343	8.747e-33	137.0	COG2207@1|root,COG2207@2|Bacteria,4NRXC@976|Bacteroidetes,1I60V@117743|Flavobacteriia	976|Bacteroidetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
MMS1_k127_330336_0	744872.Spica_0491	4.873e-130	424.0	COG0240@1|root,COG0240@2|Bacteria,2J68Z@203691|Spirochaetes	203691|Spirochaetes	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
MMS1_k127_330336_3	596324.TREVI0001_2326	5.665e-47	174.0	COG0105@1|root,COG0105@2|Bacteria,2J7SQ@203691|Spirochaetes	203691|Spirochaetes	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMS1_k127_335212_0	545694.TREPR_3604	9.523e-265	829.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2J5ZA@203691|Spirochaetes	203691|Spirochaetes	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
MMS1_k127_335220_3	1122918.KB907289_gene4409	2.631e-86	288.0	COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,4HAAG@91061|Bacilli	91061|Bacilli	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21,3.2.1.52	ko:K01207,ko:K05349	ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501	M00628	R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko00002,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_335220_0	1480694.DC28_09330	4.396e-249	792.0	COG1472@1|root,COG1472@2|Bacteria,2J6UN@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_335220_2	1480694.DC28_09325	6.733e-138	460.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
MMS1_k127_335220_5	1121011.AUCB01000007_gene1372	8.094e-25	118.0	COG2207@1|root,COG2207@2|Bacteria,4NIJV@976|Bacteroidetes,1HZK0@117743|Flavobacteriia	976|Bacteroidetes	K	AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_335220_1	411901.BACCAC_03592	8.431e-169	546.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,2FMAW@200643|Bacteroidia,4AK8N@815|Bacteroidaceae	976|Bacteroidetes	P	COG COG3119 Arylsulfatase A and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
MMS1_k127_335220_4	1480694.DC28_09330	1.648e-64	228.0	COG1472@1|root,COG1472@2|Bacteria,2J6UN@203691|Spirochaetes	203691|Spirochaetes	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
MMS1_k127_339663_4	370438.PTH_0970	3.684e-11	66.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,2625C@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
MMS1_k127_339663_1	1168034.FH5T_12760	2.123e-99	340.0	COG0373@1|root,COG0373@2|Bacteria,4NFTY@976|Bacteroidetes,2FT24@200643|Bacteroidia	976|Bacteroidetes	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS1_k127_339663_2	1408473.JHXO01000009_gene3275	4.781e-94	317.0	COG0181@1|root,COG0181@2|Bacteria,4NHH4@976|Bacteroidetes,2FSI0@200643|Bacteroidia	976|Bacteroidetes	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Porphobil_deam,Porphobil_deamC
MMS1_k127_339663_3	1089553.Tph_c02260	4.224e-13	78.0	COG1309@1|root,COG1309@2|Bacteria,1TRSH@1239|Firmicutes,25BTA@186801|Clostridia	186801|Clostridia	K	YsiA-like protein, C-terminal region	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
MMS1_k127_339663_0	1121396.KB893101_gene525	1.267e-108	360.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MISA@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
MMS1_k127_344721_0	1121451.DESAM_20647	1.893e-91	312.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42YXK@68525|delta/epsilon subdivisions,2X7YZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMS1_k127_344721_1	1322246.BN4_12505	1.848e-35	139.0	COG2199@1|root,COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,43EHM@68525|delta/epsilon subdivisions,2X8EA@28221|Deltaproteobacteria,2MHH2@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_9
MMS1_k127_345032_1	1301100.HG529268_gene607	8.87e-82	278.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,36E47@31979|Clostridiaceae	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
MMS1_k127_345032_0	573413.Spirs_1712	1.551e-175	569.0	COG1199@1|root,COG1199@2|Bacteria,2J626@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2,RadC,ResIII
MMS1_k127_350502_4	1506994.JNLQ01000001_gene92	4.774e-08	55.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQES@1239|Firmicutes,24C3N@186801|Clostridia,4BYVG@830|Butyrivibrio	186801|Clostridia	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC,Response_reg
MMS1_k127_350502_1	1506994.JNLQ01000001_gene91	4.133e-141	460.0	COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,4C24V@830|Butyrivibrio	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_350502_2	1226325.HMPREF1548_03015	2.872e-124	404.0	COG1175@1|root,COG1175@2|Bacteria,1VSHG@1239|Firmicutes,24GUI@186801|Clostridia,36Q9T@31979|Clostridiaceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_350502_3	1226325.HMPREF1548_03016	5.986e-113	370.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A3D@186801|Clostridia,36WPE@31979|Clostridiaceae	186801|Clostridia	P	transport system permease	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_350502_0	665571.STHERM_c14770	5.157e-198	620.0	COG3534@1|root,COG3534@2|Bacteria,2J6R9@203691|Spirochaetes	203691|Spirochaetes	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
MMS1_k127_350617_1	1033991.RLEG12_03150	9.921e-34	134.0	COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2TWSD@28211|Alphaproteobacteria,4B81J@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Alpha-L-arabinofuranosidase C-terminus	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
MMS1_k127_350617_0	903814.ELI_0552	1.797e-43	177.0	COG2207@1|root,COG2207@2|Bacteria,1V029@1239|Firmicutes,24GJ2@186801|Clostridia	186801|Clostridia	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,dCache_1
MMS1_k127_354451_1	1123274.KB899408_gene3813	7.666e-90	318.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_354451_0	862908.BMS_2689	1.547e-233	746.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
MMS1_k127_354451_2	675817.VDA_001139	0.0001147	45.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1RRE9@1236|Gammaproteobacteria,1XTMG@135623|Vibrionales	135623|Vibrionales	E	Histidinol phosphatase and related hydrolases of the PHP family	-	GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006928,GO:0008150,GO:0008270,GO:0009987,GO:0016787,GO:0016788,GO:0040011,GO:0042578,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
MMS1_k127_360221_1	1480694.DC28_02110	3.997e-73	253.0	COG0745@1|root,COG0745@2|Bacteria,2J7CK@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07658,ko:K18941	ko02020,map02020	M00434,M00716,M00717	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_360221_2	1480694.DC28_02115	5.333e-51	198.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA
MMS1_k127_360221_3	525904.Tter_0808	2.035e-49	185.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
MMS1_k127_360221_4	573413.Spirs_0490	1.094e-44	168.0	2C7TX@1|root,33VWG@2|Bacteria,2J836@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_360221_0	313628.LNTAR_01582	6.232e-103	341.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2,Thioredoxin
MMS1_k127_361982_4	641491.DND132_1509	1.788e-14	83.0	28IZT@1|root,2Z8X3@2|Bacteria,1R4RF@1224|Proteobacteria,42QV2@68525|delta/epsilon subdivisions,2WMYU@28221|Deltaproteobacteria,2MA9F@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_361982_0	545695.TREAZ_1421	3.948e-124	406.0	COG0618@1|root,COG0618@2|Bacteria,2J7S6@203691|Spirochaetes	203691|Spirochaetes	S	DHH superfamily protein, subfamily 1	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
MMS1_k127_361982_3	43989.cce_3596	2.369e-66	239.0	COG1051@1|root,COG1194@1|root,COG1051@2|Bacteria,COG1194@2|Bacteria,1G7MC@1117|Cyanobacteria,3KH3E@43988|Cyanothece	1117|Cyanobacteria	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
MMS1_k127_361982_1	439235.Dalk_3760	6.762e-104	351.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2WKG6@28221|Deltaproteobacteria,2MMSM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
MMS1_k127_361982_2	573413.Spirs_0320	1.373e-84	298.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_363871_4	1123274.KB899429_gene2872	1.803e-47	172.0	COG0013@1|root,COG0013@2|Bacteria,2J5G2@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS1_k127_363871_0	744872.Spica_1434	3.96e-151	486.0	COG0457@1|root,COG0457@2|Bacteria,2J5I5@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
MMS1_k127_363871_5	1123274.KB899429_gene2869	1.954e-25	109.0	291RI@1|root,2ZPBI@2|Bacteria,2J8IP@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_363871_3	1480694.DC28_11895	2.17e-58	209.0	COG0131@1|root,COG0131@2|Bacteria,2J6ZQ@203691|Spirochaetes	203691|Spirochaetes	E	imidazoleglycerol-phosphate dehydratase	hisB	-	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase_like,IGPD
MMS1_k127_363871_2	1123274.KB899429_gene2867	7.816e-78	265.0	COG0040@1|root,COG0040@2|Bacteria,2J8TS@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
MMS1_k127_363871_1	573413.Spirs_3140	3.21e-89	306.0	COG3705@1|root,COG3705@2|Bacteria,2JB3U@203691|Spirochaetes	203691|Spirochaetes	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
MMS1_k127_363871_6	445987.BVAVS116_0642	2.573e-08	58.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	ratA	-	3.5.1.28	ko:K01448,ko:K01449	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,DUF823,DUF824,LysM
MMS1_k127_366657_3	1219084.AP014508_gene1051	1.456e-21	97.0	COG0111@1|root,COG0111@2|Bacteria,2GCKK@200918|Thermotogae	200918|Thermotogae	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_366657_1	572544.Ilyop_0916	3.698e-89	307.0	COG1454@1|root,COG1454@2|Bacteria,3792I@32066|Fusobacteria	32066|Fusobacteria	C	PFAM Iron-containing alcohol dehydrogenase	fucO	-	1.1.1.77	ko:K00048	ko00630,ko00640,ko01120,map00630,map00640,map01120	-	R01781,R02257	RC00087,RC00099	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS1_k127_366657_2	889378.Spiaf_2393	8.546e-25	109.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
MMS1_k127_366657_0	338963.Pcar_0561	2.166e-133	441.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,43T92@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMS1_k127_366715_4	1167006.UWK_00694	1.66e-93	339.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
MMS1_k127_366715_8	1047013.AQSP01000139_gene2367	2.491e-30	125.0	COG1959@1|root,COG1959@2|Bacteria,2NPZX@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator	cymR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
MMS1_k127_366715_5	857293.CAAU_1774	1.065e-60	227.0	COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,36WRU@31979|Clostridiaceae	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
MMS1_k127_366715_10	1122222.AXWR01000039_gene665	1.651e-18	98.0	COG0845@1|root,COG0845@2|Bacteria,1WJ9T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23,OEP
MMS1_k127_366715_3	665571.STHERM_c19340	1.667e-106	351.0	COG1136@1|root,COG1136@2|Bacteria,2J6R3@203691|Spirochaetes	203691|Spirochaetes	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_366715_2	665571.STHERM_c19330	2.852e-110	370.0	COG0577@1|root,COG0577@2|Bacteria,2J66A@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_366715_1	665571.STHERM_c19320	3.292e-129	428.0	COG0577@1|root,COG0577@2|Bacteria,2J66A@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_366715_6	744872.Spica_0872	2.419e-50	201.0	COG2208@1|root,COG2208@2|Bacteria,2J6MM@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	SpoIIE
MMS1_k127_366715_7	889378.Spiaf_2590	1.426e-34	144.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_3,HlyD_D23
MMS1_k127_366715_0	889378.Spiaf_2589	2.781e-261	839.0	COG0841@1|root,COG0841@2|Bacteria,2J5HW@203691|Spirochaetes	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	ACR_tran,MMPL
MMS1_k127_366715_11	1410609.JHVB01000001_gene1697	0.0001244	53.0	COG1538@1|root,COG1538@2|Bacteria,2J5YA@203691|Spirochaetes	203691|Spirochaetes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS1_k127_367132_1	760011.Spico_0285	1.948e-60	216.0	COG0584@1|root,COG0584@2|Bacteria,2J689@203691|Spirochaetes	203691|Spirochaetes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
MMS1_k127_367132_2	378806.STAUR_0321	5.762e-56	200.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,42RVP@68525|delta/epsilon subdivisions,2WNCX@28221|Deltaproteobacteria,2YW7D@29|Myxococcales	28221|Deltaproteobacteria	S	Appr-1'-p processing enzyme	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
MMS1_k127_367132_0	1125699.HMPREF9194_01427	1.899e-70	244.0	COG2344@1|root,COG2344@2|Bacteria,2J67B@203691|Spirochaetes	203691|Spirochaetes	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
MMS1_k127_373357_1	882.DVU_2677	8.777e-79	280.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42TAJ@68525|delta/epsilon subdivisions,2WPXQ@28221|Deltaproteobacteria,2M903@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
MMS1_k127_373357_4	1307761.L21SP2_2305	2.939e-30	122.0	COG1342@1|root,COG1342@2|Bacteria	2|Bacteria	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134,Nitro_FeMo-Co
MMS1_k127_373357_2	1321778.HMPREF1982_02657	1.282e-77	270.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia	186801|Clostridia	S	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4,Peptidase_S9
MMS1_k127_373357_3	1262449.CP6013_0556	1.595e-59	216.0	COG2227@1|root,COG2227@2|Bacteria,1UXZZ@1239|Firmicutes,24BIT@186801|Clostridia,36EZ4@31979|Clostridiaceae	186801|Clostridia	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_373357_0	1226325.HMPREF1548_04618	1.5e-189	601.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,247VA@186801|Clostridia,36VSN@31979|Clostridiaceae	186801|Clostridia	G	MFS/sugar transport protein	lacS	-	-	ko:K03292,ko:K11104,ko:K16209	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
MMS1_k127_373357_5	1123517.JOMR01000001_gene1613	3.389e-19	93.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,GAF,GAF_2,Guanylate_cyc,HAMP,PAS_9,dCache_1
MMS1_k127_374588_3	387093.SUN_1857	2.352e-69	257.0	COG0784@1|root,COG2202@1|root,COG3287@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3287@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2YTEC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Two-component sensor histidine kinase response regulator	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,HATPase_c,HisKA,Response_reg
MMS1_k127_374588_2	1123274.KB899411_gene3208	3.997e-73	253.0	COG3271@1|root,COG3271@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	Peptidase_C39,Peptidase_C39_2,Peptidase_C70
MMS1_k127_374588_7	1144312.PMI09_00540	1.075e-06	57.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,4BBYI@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
MMS1_k127_374588_4	1121447.JONL01000006_gene6	8.394e-44	166.0	COG4191@1|root,COG4936@1|root,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2M9UV@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
MMS1_k127_374588_6	382245.ASA_4325	7.673e-16	84.0	COG1670@1|root,COG1670@2|Bacteria,1NEA7@1224|Proteobacteria,1SEG2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_374588_0	1499967.BAYZ01000095_gene4058	9.011e-148	474.0	COG0132@1|root,COG0132@2|Bacteria	2|Bacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.21,6.3.2.3,6.3.3.3	ko:K00857,ko:K01920,ko:K01935	ko00240,ko00270,ko00480,ko00780,ko00983,ko01100,map00240,map00270,map00480,map00780,map00983,map01100	M00118,M00123,M00573,M00577	R00497,R01567,R02099,R03182,R08233,R10994	RC00002,RC00017,RC00096,RC00141,RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,TK
MMS1_k127_374588_5	1280941.HY2_13405	8.472e-41	171.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,43X38@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP
MMS1_k127_374588_8	317619.ANKN01000077_gene2332	2.814e-06	55.0	2DCDW@1|root,2ZDSQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_374588_1	1265505.ATUG01000001_gene4499	4.506e-119	392.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_379126_0	573413.Spirs_1805	2.109e-115	380.0	COG0536@1|root,COG0536@2|Bacteria,2J5QY@203691|Spirochaetes	203691|Spirochaetes	C	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1,Radical_SAM
MMS1_k127_379126_1	290434.BG0806	4.178e-44	167.0	COG1057@1|root,COG1057@2|Bacteria,2J65I@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
MMS1_k127_379126_2	525367.HMPREF0556_12320	4.061e-23	108.0	COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,4HHRY@91061|Bacilli,26K25@186820|Listeriaceae	91061|Bacilli	H	HD superfamily hydrolase involved in NAD metabolism	yqeK	-	-	-	-	-	-	-	-	-	-	-	HD
MMS1_k127_379126_3	1321815.HMPREF9193_01060	2.652e-18	89.0	COG1316@1|root,COG1316@2|Bacteria,2J57I@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
MMS1_k127_380342_1	523794.Lebu_0188	9.883e-37	147.0	COG3044@1|root,COG3044@2|Bacteria,3784Y@32066|Fusobacteria	32066|Fusobacteria	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
MMS1_k127_380342_2	1245469.S58_20530	1.067e-32	138.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,2TQRM@28211|Alphaproteobacteria,3JSWG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_02360	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS1_k127_380342_0	1408473.JHXO01000006_gene1317	1.868e-81	278.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
MMS1_k127_381606_2	1121335.Clst_2143	2.123e-41	169.0	COG2972@1|root,COG2972@2|Bacteria,1UCQF@1239|Firmicutes,24EY1@186801|Clostridia	186801|Clostridia	T	signal transduction protein with a C-terminal ATPase domain	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
MMS1_k127_381606_3	1121104.AQXH01000001_gene1539	3.241e-30	122.0	COG3860@1|root,COG3860@2|Bacteria,4NX7R@976|Bacteroidetes	976|Bacteroidetes	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_381606_0	756499.Desde_1731	1.553e-93	311.0	COG0655@1|root,COG0655@2|Bacteria,1TRKM@1239|Firmicutes,24AD6@186801|Clostridia,262P5@186807|Peptococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_381606_1	646529.Desaci_2572	6.196e-63	221.0	COG1309@1|root,COG1309@2|Bacteria,1V1M7@1239|Firmicutes,24TPF@186801|Clostridia,263DA@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_382854_1	1480694.DC28_15120	4.163e-113	374.0	COG1609@1|root,COG1609@2|Bacteria,2J87T@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
MMS1_k127_382854_0	1480694.DC28_15115	3.944e-165	527.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
MMS1_k127_384700_2	1122986.KB908320_gene1529	8.807e-49	189.0	COG0252@1|root,COG0252@2|Bacteria,4NE2Z@976|Bacteroidetes,2FM3E@200643|Bacteroidia	976|Bacteroidetes	EJ	L-asparaginase, type I	ansA	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMS1_k127_384700_3	1480694.DC28_11515	2.299e-30	134.0	COG3325@1|root,COG3325@2|Bacteria	2|Bacteria	G	chitin binding	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,DUF4849
MMS1_k127_384700_0	1385935.N836_13755	9.616e-185	588.0	COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM tRNA synthetases class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS1_k127_384700_1	983917.RGE_09620	2.47e-107	362.0	COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,2VJFD@28216|Betaproteobacteria,1KMHQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ferric reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_8,Ferric_reduct,NAD_binding_1
MMS1_k127_385917_1	744872.Spica_1963	1.718e-46	176.0	COG2199@1|root,COG3706@2|Bacteria,2J8FW@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,Response_reg
MMS1_k127_385917_0	709991.Odosp_3277	5.67e-116	386.0	COG1143@1|root,COG4624@1|root,COG1143@2|Bacteria,COG4624@2|Bacteria,4NGF4@976|Bacteroidetes,2FPND@200643|Bacteroidia,22WV7@171551|Porphyromonadaceae	976|Bacteroidetes	C	Hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4
MMS1_k127_390847_0	491952.Mar181_0905	2.819e-307	975.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales	135619|Oceanospirillales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,MHYT,PAS,PAS_4,PAS_9,SBP_bac_3,dCache_1
MMS1_k127_390847_1	1173029.JH980292_gene1451	7.729e-51	208.0	COG0642@1|root,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	GAF,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1
MMS1_k127_39233_0	906968.Trebr_0432	3.63e-31	129.0	COG0438@1|root,COG0438@2|Bacteria,2J60X@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_39233_1	744872.Spica_1194	1.158e-27	128.0	2FJ33@1|root,34ATE@2|Bacteria,2J862@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_39233_2	1259795.ARJK01000005_gene1308	4.16e-14	86.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1UNZB@1239|Firmicutes,24SMW@186801|Clostridia	186801|Clostridia	T	diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GGDEF
MMS1_k127_398577_1	1123274.KB899412_gene1434	8.577e-191	610.0	COG1529@1|root,COG1529@2|Bacteria,2J727@203691|Spirochaetes	203691|Spirochaetes	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
MMS1_k127_398577_0	1322246.BN4_11180	1.456e-205	650.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,42M4U@68525|delta/epsilon subdivisions,2WJAG@28221|Deltaproteobacteria,2MGSA@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Permease family	-	-	-	ko:K03458,ko:K16345	-	-	-	-	ko00000,ko02000	2.A.40,2.A.40.4.2	-	-	Xan_ur_permease
MMS1_k127_398577_2	1116369.KB890024_gene4870	1.183e-16	86.0	COG4977@1|root,COG4977@2|Bacteria,1R2DC@1224|Proteobacteria,2TZI8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
MMS1_k127_400222_0	1321778.HMPREF1982_00750	3.2e-233	735.0	COG1164@1|root,COG1164@2|Bacteria,1TQ5W@1239|Firmicutes,25CE1@186801|Clostridia,26CHZ@186813|unclassified Clostridiales	186801|Clostridia	E	Peptidase family M3	pepF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
MMS1_k127_400222_3	443144.GM21_3084	5.009e-12	77.0	COG2067@1|root,COG2067@2|Bacteria,1RFDS@1224|Proteobacteria,42UMQ@68525|delta/epsilon subdivisions,2WQY1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
MMS1_k127_400222_2	1121374.KB891586_gene2496	8.321e-135	451.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	OU	Signal peptide peptidase	sppA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMS1_k127_400222_1	765869.BDW_10090	1.783e-229	724.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2MTH2@213481|Bdellovibrionales,2WIIV@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	aconitate hydratase	aco	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMS1_k127_402252_4	573413.Spirs_1581	3.593e-68	235.0	COG1377@1|root,COG1377@2|Bacteria,2J5EU@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
MMS1_k127_402252_0	573413.Spirs_1582	2.259e-300	935.0	COG1298@1|root,COG1298@2|Bacteria,2J57F@203691|Spirochaetes	203691|Spirochaetes	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
MMS1_k127_402252_3	744872.Spica_1524	2.517e-121	401.0	COG1419@1|root,COG1419@2|Bacteria,2J5TV@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein FlhF	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
MMS1_k127_402252_1	744872.Spica_1523	5.097e-128	415.0	COG0455@1|root,COG0455@2|Bacteria,2J5B7@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the ParA family	fleN	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,ParA
MMS1_k127_402252_2	1123274.KB899413_gene831	9.258e-122	395.0	COG1191@1|root,COG1191@2|Bacteria,2J5RA@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS1_k127_402252_5	665571.STHERM_c09350	6.95e-05	46.0	COG1315@1|root,COG1315@2|Bacteria,2J5S8@203691|Spirochaetes	203691|Spirochaetes	L	COGs COG1315 polymerase most protein contain PALM domain HD hydrolase domain and Zn-ribbon domain	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA,Jag_N
MMS1_k127_402892_0	180332.JTGN01000004_gene2518	3.023e-152	496.0	COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia	186801|Clostridia	G	Alpha-L-rhamnosidase N-terminal domain protein	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
MMS1_k127_402892_1	1121396.KB893024_gene3911	4.275e-121	396.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2MKTN@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMS1_k127_402892_2	158190.SpiGrapes_2297	6.076e-17	86.0	COG2964@1|root,COG2964@2|Bacteria	2|Bacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_22,PAS_6
MMS1_k127_403935_1	555779.Dthio_PD1991	1.096e-06	54.0	COG4423@1|root,COG4423@2|Bacteria,1NDG1@1224|Proteobacteria	1224|Proteobacteria	S	Transcription factor	-	-	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
MMS1_k127_403935_0	158190.SpiGrapes_2293	2.236e-138	447.0	COG0514@1|root,COG0514@2|Bacteria,2J602@203691|Spirochaetes	203691|Spirochaetes	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
MMS1_k127_404672_0	1480694.DC28_01270	1.545e-272	852.0	COG0458@1|root,COG0458@2|Bacteria,2J6A8@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS1_k127_408565_0	264462.Bd1089	1.432e-13	81.0	2DFE2@1|root,2ZRIA@2|Bacteria,1PBDC@1224|Proteobacteria,432DY@68525|delta/epsilon subdivisions,2MUGE@213481|Bdellovibrionales,2WY55@28221|Deltaproteobacteria	213481|Bdellovibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_408565_1	1392487.JIAD01000001_gene1656	2.829e-06	53.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,25V16@186806|Eubacteriaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	ydfH_4	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_412857_1	906968.Trebr_0131	1.562e-132	433.0	COG1879@1|root,COG1879@2|Bacteria,2J5Z1@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10540	ko02010,ko02030,map02010,map02030	M00214	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.3	-	-	Peripla_BP_4
MMS1_k127_412857_0	484770.UFO1_2753	9.99e-190	608.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H2EG@909932|Negativicutes	909932|Negativicutes	G	ABC transporter	mglA	-	3.6.3.17	ko:K10542	ko02010,map02010	M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.3	-	-	ABC_tran
MMS1_k127_412857_2	1125699.HMPREF9194_01728	1.572e-131	427.0	COG1172@1|root,COG1172@2|Bacteria,2JBGR@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10541,ko:K17214	ko02010,map02010	M00214,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.3	-	-	BPD_transp_2
MMS1_k127_413173_1	357808.RoseRS_3483	7.47e-20	95.0	2DN0I@1|root,32UR2@2|Bacteria,2G8Y2@200795|Chloroflexi,375Q5@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4405
MMS1_k127_413173_0	557599.MKAN_01425	1.166e-69	248.0	COG3250@1|root,COG3250@2|Bacteria,2I952@201174|Actinobacteria,23C33@1762|Mycobacteriaceae	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
MMS1_k127_413173_2	946077.W5A_11651	1.36e-12	76.0	COG2968@1|root,COG2968@2|Bacteria,4NPHH@976|Bacteroidetes,1I26H@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
MMS1_k127_41374_1	1125701.HMPREF1221_00946	7.136e-90	306.0	2AN2V@1|root,31D0F@2|Bacteria,2J9FW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
MMS1_k127_41374_2	202952.BBLI01000005_gene556	2.983e-11	72.0	290UI@1|root,2ZNGI@2|Bacteria,1QSJH@1224|Proteobacteria,1RW1K@1236|Gammaproteobacteria,3NK0J@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_41374_0	1279009.ADICEAN_00942	1.952e-156	511.0	COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,47KYC@768503|Cytophagia	976|Bacteroidetes	M	penicillin-binding protein 1C	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
MMS1_k127_415196_4	1123274.KB899416_gene2585	1.267e-15	79.0	2DQZ2@1|root,339GP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_415196_5	1123274.KB899416_gene2585	2.361e-10	63.0	2DQZ2@1|root,339GP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_415196_3	889378.Spiaf_2310	2.154e-22	102.0	298IC@1|root,2ZVPA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_415196_2	1278307.KB906982_gene3982	1.837e-27	122.0	COG0834@1|root,COG0834@2|Bacteria,1REJ0@1224|Proteobacteria,1S7S1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_415196_1	526225.Gobs_2291	4.811e-40	154.0	COG4702@1|root,COG4702@2|Bacteria,2IFGG@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0303 family	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
MMS1_k127_415196_0	760011.Spico_0105	4.735e-91	306.0	COG1882@1|root,COG1882@2|Bacteria,2J6MA@203691|Spirochaetes	203691|Spirochaetes	H	formate C-acetyltransferase	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
MMS1_k127_418179_2	748727.CLJU_c39000	5.567e-34	136.0	COG1846@1|root,COG1846@2|Bacteria,1V3PS@1239|Firmicutes,24I6N@186801|Clostridia,36IX9@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS1_k127_418179_1	1211817.CCAT010000048_gene2592	7.51e-39	152.0	COG0454@1|root,COG0456@2|Bacteria,1VCVY@1239|Firmicutes,25B31@186801|Clostridia,36W7C@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_418179_0	1304880.JAGB01000002_gene1606	5.542e-90	303.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,247Z9@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS1_k127_423152_3	1449126.JQKL01000002_gene1674	1.544e-85	287.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,268UM@186813|unclassified Clostridiales	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_423152_0	1449126.JQKL01000002_gene1675	3.505e-243	759.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,26845@186813|unclassified Clostridiales	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
MMS1_k127_423152_1	1449126.JQKL01000002_gene1676	7.604e-156	499.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,267P3@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	tmpC	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
MMS1_k127_423152_2	404589.Anae109_0951	5.151e-87	295.0	COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,42NKQ@68525|delta/epsilon subdivisions,2WJVF@28221|Deltaproteobacteria,2YX5T@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
MMS1_k127_423265_3	324057.Pjdr2_5023	9.401e-40	154.0	2DM0V@1|root,318CA@2|Bacteria,1V7T1@1239|Firmicutes,4I7YW@91061|Bacilli,26Y87@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_423265_2	1347392.CCEZ01000049_gene1451	6.326e-52	190.0	2CYTA@1|root,32T4T@2|Bacteria,1VCWS@1239|Firmicutes,24JBX@186801|Clostridia,36H2Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
MMS1_k127_423265_4	1499967.BAYZ01000028_gene1229	9e-31	130.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_423265_1	1286171.EAL2_c17070	4.507e-87	293.0	arCOG13338@1|root,2ZA1I@2|Bacteria,1V5GH@1239|Firmicutes,2488N@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF5058
MMS1_k127_423265_0	1286171.EAL2_c17060	6.669e-88	297.0	arCOG13339@1|root,2ZBXW@2|Bacteria,1V1KG@1239|Firmicutes,24MP4@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_423265_5	1286171.EAL2_808p04780	3.822e-18	86.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,25VU9@186806|Eubacteriaceae	186801|Clostridia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
MMS1_k127_424662_1	1480694.DC28_14870	3.217e-78	263.0	COG0525@1|root,COG0525@2|Bacteria,2J659@203691|Spirochaetes	203691|Spirochaetes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
MMS1_k127_424662_2	906968.Trebr_2139	2.472e-27	115.0	COG1186@1|root,COG1186@2|Bacteria,2J8DU@203691|Spirochaetes	203691|Spirochaetes	J	PFAM Class I peptide chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
MMS1_k127_424662_0	443143.GM18_0728	9.411e-279	868.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ABC transporter related	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
MMS1_k127_425133_2	59374.Fisuc_3002	7.774e-55	203.0	COG0304@1|root,COG0304@2|Bacteria	2|Bacteria	I	3-oxoacyl-[acyl-carrier-protein] synthase activity	fabF2	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_425133_6	1265503.KB905166_gene858	7.611e-06	55.0	2CBA7@1|root,32Y47@2|Bacteria,1NBW1@1224|Proteobacteria,1SF21@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3261)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3261
MMS1_k127_425133_1	59374.Fisuc_3003	1.42e-102	362.0	COG4258@1|root,COG4258@2|Bacteria	2|Bacteria	I	3-demethylubiquinone-9 3-O-methyltransferase activity	VP0886	-	-	-	-	-	-	-	-	-	-	-	MMPL
MMS1_k127_425133_5	1123261.AXDW01000003_gene1780	2.896e-12	75.0	COG2834@1|root,COG2834@2|Bacteria,1N9W4@1224|Proteobacteria,1SCRF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA
MMS1_k127_425133_3	1316936.K678_16961	3.06e-40	153.0	COG0824@1|root,COG0824@2|Bacteria,1RH6W@1224|Proteobacteria,2UADR@28211|Alphaproteobacteria,2JT3M@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
MMS1_k127_425133_0	59374.Fisuc_3006	6.637e-212	669.0	COG2986@1|root,COG2986@2|Bacteria	2|Bacteria	E	ammonia-lyase activity	hutH	GO:0003674,GO:0003824,GO:0016829,GO:0016840,GO:0016841,GO:0016853,GO:0016866,GO:0016869,GO:0050368	4.3.1.23,4.3.1.24,4.3.1.3,5.4.3.6	ko:K01745,ko:K10774,ko:K10775,ko:K21181	ko00340,ko00350,ko00360,ko00940,ko01059,ko01100,ko01110,ko01130,map00340,map00350,map00360,map00940,map01059,map01100,map01110,map01130	M00039,M00045,M00137,M00350,M00827,M00828	R00697,R00737,R01168,R11366	RC00361,RC00366	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMS1_k127_425133_4	59374.Fisuc_3007	1.54e-32	130.0	COG4261@1|root,COG4261@2|Bacteria	2|Bacteria	M	Acyltransferase	ycdQ	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Lip_A_acyltrans
MMS1_k127_4302_0	945713.IALB_2455	1.604e-48	188.0	COG2348@1|root,COG2348@2|Bacteria	2|Bacteria	V	transferase activity, transferring amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB
MMS1_k127_430456_0	889378.Spiaf_0513	8.737e-161	519.0	COG1288@1|root,COG1288@2|Bacteria,2J88I@203691|Spirochaetes	203691|Spirochaetes	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
MMS1_k127_430456_1	1089547.KB913013_gene2826	9.281e-32	130.0	COG0624@1|root,COG0624@2|Bacteria,4NEHJ@976|Bacteroidetes,47MC5@768503|Cytophagia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS1_k127_431010_3	1417230.AYOT01000225_gene123	1.06e-18	92.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
MMS1_k127_431010_1	243275.TDE_2292	4.037e-53	191.0	COG0245@1|root,COG0245@2|Bacteria,2J7UY@203691|Spirochaetes	203691|Spirochaetes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
MMS1_k127_431010_2	573413.Spirs_4117	2.787e-42	163.0	COG1211@1|root,COG1211@2|Bacteria,2J6JT@203691|Spirochaetes	203691|Spirochaetes	I	Belongs to the IspD TarI cytidylyltransferase family. IspD subfamily	ispD	-	2.7.7.60,4.6.1.12	ko:K00991,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
MMS1_k127_431010_0	1123274.KB899414_gene3722	6.315e-63	220.0	COG1329@1|root,COG1329@2|Bacteria,2J7TP@203691|Spirochaetes	203691|Spirochaetes	K	Transcription factor	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
MMS1_k127_431010_4	1417230.AYOT01000223_gene841	1.515e-10	66.0	COG1580@1|root,COG1580@2|Bacteria,2J7MX@203691|Spirochaetes	203691|Spirochaetes	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
MMS1_k127_43103_14	1265503.KB905169_gene243	3.941e-06	55.0	COG0834@1|root,COG0834@2|Bacteria,1PDWE@1224|Proteobacteria,1TBKJ@1236|Gammaproteobacteria,2Q8DI@267889|Colwelliaceae	1236|Gammaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_43103_12	1499967.BAYZ01000150_gene1719	2.397e-49	183.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	ppaX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K13292	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_43103_6	443254.Marpi_0484	3.418e-97	323.0	COG1028@1|root,COG1028@2|Bacteria,2GCDH@200918|Thermotogae	200918|Thermotogae	IQ	Short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS1_k127_43103_0	1307761.L21SP2_1975	8.54e-199	627.0	COG0427@1|root,COG0427@2|Bacteria,2J67X@203691|Spirochaetes	203691|Spirochaetes	C	the current gene model (or a revised gene model) may contain a frame shift	-	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
MMS1_k127_43103_2	1116375.VEJY3_17606	1.436e-149	483.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XSMR@135623|Vibrionales	135623|Vibrionales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_43103_11	403833.Pmob_0504	2.13e-55	203.0	COG0596@1|root,COG4177@1|root,COG0596@2|Bacteria,COG4177@2|Bacteria,2GC2F@200918|Thermotogae	200918|Thermotogae	EI	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Abhydrolase_1,BPD_transp_2
MMS1_k127_43103_7	443254.Marpi_1265	4.761e-83	289.0	COG1309@1|root,COG1309@2|Bacteria,2GD9U@200918|Thermotogae	200918|Thermotogae	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_43103_3	1307761.L21SP2_1979	1.723e-136	442.0	COG0332@1|root,COG0332@2|Bacteria	2|Bacteria	I	beta-ketoacyl-acyl-carrier-protein synthase III activity	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
MMS1_k127_43103_8	1307761.L21SP2_2681	4.917e-82	281.0	COG2267@1|root,COG2267@2|Bacteria,2J987@203691|Spirochaetes	203691|Spirochaetes	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_43103_9	1307761.L21SP2_1978	8.734e-79	271.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K02167	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_6,TetR_N
MMS1_k127_43103_13	1307761.L21SP2_1978	1.25e-20	96.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K02167	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_6,TetR_N
MMS1_k127_43103_1	1307761.L21SP2_1973	8.464e-166	526.0	COG0332@1|root,COG0332@2|Bacteria	2|Bacteria	I	beta-ketoacyl-acyl-carrier-protein synthase III activity	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
MMS1_k127_43103_5	1307761.L21SP2_1972	2.507e-98	326.0	COG0410@1|root,COG0410@2|Bacteria,2J5VQ@203691|Spirochaetes	203691|Spirochaetes	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
MMS1_k127_43103_4	1307761.L21SP2_1971	5.209e-99	328.0	COG0411@1|root,COG0411@2|Bacteria,2J67E@203691|Spirochaetes	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
MMS1_k127_43103_10	403833.Pmob_0512	2.048e-69	241.0	COG4177@1|root,COG4177@2|Bacteria,2GC02@200918|Thermotogae	200918|Thermotogae	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
MMS1_k127_432210_4	264732.Moth_1888	7.624e-21	93.0	COG3383@1|root,COG3383@2|Bacteria,1TTC3@1239|Firmicutes,24BAV@186801|Clostridia,42I2T@68295|Thermoanaerobacterales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	-	1.17.1.11	ko:K22338	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4,Fer4_21,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
MMS1_k127_432210_0	443144.GM21_2804	5.385e-228	721.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	bamH	-	1.6.5.3	ko:K00124,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_2080	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
MMS1_k127_432210_3	926561.KB900620_gene3055	3.515e-41	156.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,3WBPU@53433|Halanaerobiales	186801|Clostridia	C	PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit	-	-	1.12.1.3,1.6.5.3	ko:K00334,ko:K18330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
MMS1_k127_432210_2	574087.Acear_0984	8.204e-48	177.0	COG0437@1|root,COG0437@2|Bacteria,1UJ6Q@1239|Firmicutes,25EWT@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_11
MMS1_k127_432210_1	909663.KI867150_gene97	4.281e-76	260.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MQ8Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
MMS1_k127_435644_0	313612.L8106_09111	8.857e-88	304.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1HHU4@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HAMP,HATPase_c,HisKA,PAS,PAS_2,PAS_3,PAS_4,PAS_9,PHY,Response_reg,dCache_1
MMS1_k127_439010_0	1122947.FR7_3339	1.313e-70	244.0	COG1878@1|root,COG1878@2|Bacteria,1TSXB@1239|Firmicutes,4H6DM@909932|Negativicutes	909932|Negativicutes	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
MMS1_k127_439010_1	1499689.CCNN01000006_gene521	5.457e-30	127.0	COG0454@1|root,COG0456@2|Bacteria,1VDKW@1239|Firmicutes,24HZW@186801|Clostridia,36JBB@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_442312_1	1480694.DC28_03315	9.735e-119	408.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_442312_0	632292.Calhy_0067	2.503e-151	492.0	COG1653@1|root,COG1653@2|Bacteria,1TT6U@1239|Firmicutes,24EY7@186801|Clostridia,42IQ1@68295|Thermoanaerobacterales	186801|Clostridia	G	extracellular solute-binding	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
MMS1_k127_442312_2	632292.Calhy_0068	9.554e-94	316.0	COG1175@1|root,COG1175@2|Bacteria,1UYC1@1239|Firmicutes,24BBJ@186801|Clostridia,42IDF@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_442312_3	632292.Calhy_0069	1.05e-88	301.0	COG0395@1|root,COG0395@2|Bacteria,1UZ88@1239|Firmicutes,24AP6@186801|Clostridia	186801|Clostridia	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_442312_4	472759.Nhal_1987	1.99e-30	126.0	COG0610@1|root,COG2852@1|root,COG0610@2|Bacteria,COG2852@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1WXDN@135613|Chromatiales	135613|Chromatiales	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
MMS1_k127_442312_5	102129.Lepto7375DRAFT_2986	8.944e-30	120.0	2EMA9@1|root,33EZA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_443646_1	1123274.KB899407_gene206	2.182e-57	206.0	COG0705@1|root,COG0705@2|Bacteria,2J7HV@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
MMS1_k127_443646_3	665571.STHERM_c21740	1.473e-20	100.0	2FBC5@1|root,343I0@2|Bacteria,2J6WZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_443646_0	862908.BMS_1903	1.39e-157	504.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2MSP2@213481|Bdellovibrionales,2WJ42@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
MMS1_k127_443646_2	862908.BMS_1902	8.795e-27	112.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2MSSX@213481|Bdellovibrionales,2WJ7V@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
MMS1_k127_443769_0	1123312.KB904579_gene544	5.014e-06	58.0	COG1388@1|root,COG3209@1|root,COG3210@1|root,COG1388@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1TR8F@1239|Firmicutes,4HBZE@91061|Bacilli	91061|Bacilli	M	COG3209 Rhs family protein	wapA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0004549,GO:0006139,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016078,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	RHS_repeat
MMS1_k127_447409_6	469604.HMPREF0946_00201	2.658e-48	188.0	COG4394@1|root,COG4394@2|Bacteria,3795P@32066|Fusobacteria	32066|Fusobacteria	S	Uncharacterized protein conserved in bacteria (DUF2331)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2331
MMS1_k127_447409_0	158190.SpiGrapes_1601	0.0	1013.0	COG1501@1|root,COG1501@2|Bacteria,2J722@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
MMS1_k127_447409_2	158190.SpiGrapes_1602	8.577e-129	419.0	COG0395@1|root,COG0395@2|Bacteria,2J786@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_447409_3	158190.SpiGrapes_1603	1.604e-120	394.0	COG1175@1|root,COG1175@2|Bacteria,2J7SD@203691|Spirochaetes	203691|Spirochaetes	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_447409_1	158190.SpiGrapes_1604	5.037e-190	601.0	COG1653@1|root,COG1653@2|Bacteria,2J82N@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
MMS1_k127_447409_4	158190.SpiGrapes_1605	8.1e-119	392.0	COG1609@1|root,COG1609@2|Bacteria,2JA9V@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
MMS1_k127_447409_5	335543.Sfum_2837	4.328e-61	234.0	COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,42QA2@68525|delta/epsilon subdivisions,2X7QC@28221|Deltaproteobacteria,2MQRX@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS_9
MMS1_k127_450390_2	545694.TREPR_1918	1.332e-10	66.0	28UHW@1|root,2ZGNJ@2|Bacteria,2J8AR@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
MMS1_k127_450390_0	665571.STHERM_c07620	2.323e-241	760.0	COG1256@1|root,COG1256@2|Bacteria,2J5TQ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein, FlgK	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,Flg_bbr_C
MMS1_k127_450390_1	1307761.L21SP2_1229	5.906e-64	226.0	COG1344@1|root,COG1344@2|Bacteria,2J6BJ@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar hook-associated protein 3	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_IN,Flagellin_N
MMS1_k127_450543_4	158189.SpiBuddy_1090	2.272e-41	165.0	COG2256@1|root,COG2256@2|Bacteria,2J604@203691|Spirochaetes	203691|Spirochaetes	L	COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
MMS1_k127_450543_5	1449336.JQLO01000001_gene344	1.289e-06	52.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_450543_1	1123274.KB899417_gene2166	1.811e-130	431.0	COG0544@1|root,COG0544@2|Bacteria,2J5FS@203691|Spirochaetes	203691|Spirochaetes	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
MMS1_k127_450543_3	1480694.DC28_07025	6.158e-97	321.0	COG0740@1|root,COG0740@2|Bacteria,2J5VY@203691|Spirochaetes	203691|Spirochaetes	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
MMS1_k127_450543_0	1123274.KB899417_gene2164	2.358e-200	631.0	COG1219@1|root,COG1219@2|Bacteria,2J5FF@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
MMS1_k127_450543_2	573413.Spirs_1293	2.903e-97	328.0	COG0466@1|root,COG0466@2|Bacteria,2J71Y@203691|Spirochaetes	203691|Spirochaetes	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS1_k127_450883_2	1280671.AUJH01000011_gene3303	2.44e-130	420.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,4BY42@830|Butyrivibrio	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS1_k127_450883_1	926569.ANT_06650	2.676e-159	512.0	COG1173@1|root,COG1173@2|Bacteria,2G648@200795|Chloroflexi	200795|Chloroflexi	P	COGs COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_450883_0	1414720.CBYM010000014_gene2772	1.263e-170	540.0	COG0444@1|root,COG0444@2|Bacteria,1UYM7@1239|Firmicutes,249WA@186801|Clostridia,36QW8@31979|Clostridiaceae	186801|Clostridia	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS1_k127_450883_3	1499684.CCNP01000019_gene2123	4.381e-30	121.0	COG4608@1|root,COG4608@2|Bacteria,1V0JP@1239|Firmicutes,24DNW@186801|Clostridia,36QK6@31979|Clostridiaceae	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS1_k127_453197_8	158190.SpiGrapes_1024	4.75e-50	185.0	COG0745@1|root,COG0745@2|Bacteria,2J63S@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_453197_3	744872.Spica_0495	6.588e-139	449.0	COG0180@1|root,COG0180@2|Bacteria,2J68U@203691|Spirochaetes	203691|Spirochaetes	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS1_k127_453197_2	1307761.L21SP2_1963	8.618e-188	603.0	COG1109@1|root,COG1109@2|Bacteria,2J6Q6@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	femD	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_III
MMS1_k127_453197_4	889378.Spiaf_1797	3.25e-132	432.0	COG2089@1|root,COG2089@2|Bacteria,2J662@203691|Spirochaetes	203691|Spirochaetes	M	Sialic acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
MMS1_k127_453197_1	1307761.L21SP2_2214	1.718e-196	620.0	COG0172@1|root,COG0172@2|Bacteria,2J5EM@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMS1_k127_453197_6	526226.Gbro_0288	1.509e-65	228.0	2EXKQ@1|root,33QWN@2|Bacteria,2IG8N@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2781)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2781
MMS1_k127_453197_7	349521.HCH_01196	1.082e-53	198.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_453197_0	744872.Spica_0722	2.126e-218	694.0	COG1164@1|root,COG1164@2|Bacteria,2J5JT@203691|Spirochaetes	203691|Spirochaetes	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
MMS1_k127_453197_5	1123274.KB899417_gene2159	3.294e-67	235.0	COG0127@1|root,COG0127@2|Bacteria,2J7BY@203691|Spirochaetes	203691|Spirochaetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS1_k127_453197_9	665571.STHERM_c05770	2.053e-19	98.0	2AMT3@1|root,31CPK@2|Bacteria,2J8CQ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_454674_0	1480694.DC28_12080	6.028e-47	187.0	COG0681@1|root,COG0681@2|Bacteria,2J6RU@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the peptidase S26 family	lepB-2	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
MMS1_k127_456869_0	1123274.KB899412_gene1498	9.404e-107	357.0	COG0771@1|root,COG0771@2|Bacteria,2J5IW@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS1_k127_456869_1	1487921.DP68_07075	6.628e-82	283.0	COG1387@1|root,COG1387@2|Bacteria,1TQQX@1239|Firmicutes,247MM@186801|Clostridia,36GKW@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
MMS1_k127_458564_3	1123372.AUIT01000018_gene1412	3.815e-18	92.0	COG0840@1|root,COG0840@2|Bacteria,2GHSJ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	NT	EAL-domain associated signalling protein domain	-	-	-	-	-	-	-	-	-	-	-	-	MCPsignal,dCache_1
MMS1_k127_458564_4	666685.R2APBS1_0223	0.000458	54.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1SG73@1236|Gammaproteobacteria,1X5NU@135614|Xanthomonadales	135614|Xanthomonadales	M	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,Calx-beta,He_PIG
MMS1_k127_458564_1	1307761.L21SP2_0440	9.691e-39	165.0	2C0A1@1|root,33WBM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_458564_0	1307761.L21SP2_0435	9.77e-168	546.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
MMS1_k127_458564_2	491952.Mar181_1750	3.987e-22	100.0	COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,1RMZ7@1236|Gammaproteobacteria,1XJDP@135619|Oceanospirillales	135619|Oceanospirillales	J	synthase	truC	-	5.4.99.26	ko:K06175	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_2
MMS1_k127_461748_0	313595.P700755_000965	1.566e-146	492.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia,4C2EY@83612|Psychroflexus	976|Bacteroidetes	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_462134_1	1123518.ARWI01000001_gene565	4.487e-44	166.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,1RN4N@1236|Gammaproteobacteria,460VZ@72273|Thiotrichales	72273|Thiotrichales	J	RNA pseudouridylate synthase	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
MMS1_k127_462134_0	658086.HMPREF0994_02775	1.042e-248	781.0	COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,27IXD@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Domain of unknown function (DUF3362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
MMS1_k127_470918_0	469616.FMAG_01467	2.702e-136	443.0	COG0151@1|root,COG0151@2|Bacteria,378PI@32066|Fusobacteria	32066|Fusobacteria	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMS1_k127_470918_3	469616.FMAG_01465	2.673e-52	192.0	COG0299@1|root,COG0299@2|Bacteria,379YW@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
MMS1_k127_470918_1	526218.Sterm_2110	1.562e-129	421.0	COG0150@1|root,COG0150@2|Bacteria,378FU@32066|Fusobacteria	32066|Fusobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS1_k127_470918_2	1499689.CCNN01000007_gene1237	2.686e-54	193.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,36ECS@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMS1_k127_471033_1	1348635.BBJY01000020_gene2758	1.308e-158	505.0	COG4225@1|root,COG4225@2|Bacteria,1NQTS@1224|Proteobacteria,1RRKB@1236|Gammaproteobacteria,1Y02R@135623|Vibrionales	135623|Vibrionales	S	Glycosyl Hydrolase Family 88	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
MMS1_k127_471033_0	760011.Spico_1734	5.26e-206	661.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_49N,Hepar_II_III,Hepar_II_III_N
MMS1_k127_471033_2	1121335.Clst_1342	9.205e-37	144.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,3WP93@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_471783_0	1307761.L21SP2_3397	1.739e-300	940.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890,ko:K06878	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,RNA_ligase,tRNA_bind
MMS1_k127_472829_0	179408.Osc7112_3588	1.019e-183	603.0	COG0001@1|root,COG0236@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0236@2|Bacteria,COG3321@2|Bacteria,1G25N@1117|Cyanobacteria,1HA4D@1150|Oscillatoriales	1117|Cyanobacteria	HQ	Acyl transferase domain in polyketide synthase (PKS) enzymes.	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
MMS1_k127_477727_5	439235.Dalk_1515	2.828e-31	126.0	COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2WIPH@28221|Deltaproteobacteria,2MHW8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	cofactor biosynthesis protein NifB	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Nitro_FeMo-Co,Radical_SAM
MMS1_k127_477727_3	290315.Clim_0677	3.335e-39	148.0	COG3411@1|root,COG3411@2|Bacteria,1FE2Q@1090|Chlorobi	1090|Chlorobi	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_477727_1	340177.Cag_1229	5.831e-80	280.0	COG0119@1|root,COG0119@2|Bacteria,1FD80@1090|Chlorobi	1090|Chlorobi	H	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
MMS1_k127_477727_0	517418.Ctha_1655	2.415e-171	552.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria,1FDE4@1090|Chlorobi	1090|Chlorobi	KT	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
MMS1_k127_477727_6	1123008.KB905694_gene1653	6.636e-31	127.0	COG0454@1|root,COG0456@2|Bacteria,4NTGT@976|Bacteroidetes,2FUEM@200643|Bacteroidia,22YGW@171551|Porphyromonadaceae	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_477727_2	1307761.L21SP2_3315	8.278e-40	150.0	COG3093@1|root,COG3093@2|Bacteria,2J910@203691|Spirochaetes	203691|Spirochaetes	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
MMS1_k127_477727_4	1307761.L21SP2_3314	1.436e-36	138.0	COG3549@1|root,COG3549@2|Bacteria	2|Bacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
MMS1_k127_479475_1	610130.Closa_2711	7.062e-12	65.0	COG1592@1|root,COG1592@2|Bacteria	2|Bacteria	C	Rubrerythrin	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin,Rubrerythrin
MMS1_k127_479475_0	158190.SpiGrapes_1030	1.727e-55	198.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4_7
MMS1_k127_479475_2	1414720.CBYM010000006_gene1272	1.484e-05	57.0	COG2199@1|root,COG2199@2|Bacteria,1VQTU@1239|Firmicutes,24D8M@186801|Clostridia,36GZE@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_490176_1	1298920.KI911353_gene973	3.105e-15	81.0	COG1653@1|root,COG1653@2|Bacteria,1TPBS@1239|Firmicutes,24K16@186801|Clostridia,22139@1506553|Lachnoclostridium	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_490176_0	1121335.Clst_0845	1.821e-43	171.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia	186801|Clostridia	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_490176_2	1403819.BATR01000002_gene103	5.876e-11	71.0	COG1413@1|root,COG2010@1|root,COG2133@1|root,COG3828@1|root,COG1413@2|Bacteria,COG2010@2|Bacteria,COG2133@2|Bacteria,COG3828@2|Bacteria,46UMZ@74201|Verrucomicrobia,2IV99@203494|Verrucomicrobiae	203494|Verrucomicrobiae	CG	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,ThuA
MMS1_k127_493019_1	180332.JTGN01000006_gene3313	1.513e-43	169.0	COG0395@1|root,COG0395@2|Bacteria,1TPRC@1239|Firmicutes,24CFT@186801|Clostridia	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_493019_0	877421.AUJT01000027_gene3480	7.821e-99	327.0	COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,24ADV@186801|Clostridia,27S04@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_493059_1	1307761.L21SP2_2920	9.825e-49	177.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2J6HE@203691|Spirochaetes	203691|Spirochaetes	F	Orotidine 5''-phosphate decarboxylase	pyrF	-	2.4.2.10,4.1.1.23	ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
MMS1_k127_493059_0	1123274.KB899426_gene2785	4.4e-99	336.0	COG3264@1|root,COG3264@2|Bacteria	2|Bacteria	M	cellular water homeostasis	kefA	-	-	ko:K05802,ko:K22051	-	-	-	-	ko00000,ko02000	1.A.23.1.1,1.A.23.1.2,1.A.23.1.3	-	-	DEP,MS_channel,cNMP_binding
MMS1_k127_493059_2	573413.Spirs_3667	7.478e-36	149.0	COG2813@1|root,COG2813@2|Bacteria,2J7DS@203691|Spirochaetes	203691|Spirochaetes	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	-	-	-	-	-	-	-	-	-	MTS
MMS1_k127_493146_1	1123053.AUDG01000042_gene935	1.627e-42	168.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Esterase_phd
MMS1_k127_493146_0	1444309.JAQG01000061_gene1181	4.131e-46	173.0	COG3271@1|root,COG3271@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2
MMS1_k127_493146_2	1122138.AQUZ01000007_gene3050	3.194e-19	89.0	COG0500@1|root,COG2226@2|Bacteria,2II6W@201174|Actinobacteria,4DVHR@85009|Propionibacteriales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
MMS1_k127_502583_0	479433.Caci_2238	1.424e-58	210.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_502583_1	1254432.SCE1572_03365	7.526e-46	178.0	COG0596@1|root,COG0596@2|Bacteria,1R2SJ@1224|Proteobacteria	1224|Proteobacteria	S	Alpha/beta hydrolase family	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
MMS1_k127_50619_0	1120953.AUBH01000004_gene3171	1.02e-64	248.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,4646N@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Methyl-accepting chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Cache_3-Cache_2,HAMP,MCPsignal,NIT,PAS_3,PAS_8,PAS_9
MMS1_k127_50619_2	588581.Cpap_1720	1.833e-23	105.0	COG0640@1|root,COG0640@2|Bacteria,1VJC2@1239|Firmicutes,24RH4@186801|Clostridia,3WMPX@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS1_k127_50619_1	588581.Cpap_1721	5.977e-39	156.0	COG2918@1|root,COG2918@2|Bacteria,1TPGX@1239|Firmicutes,25ER3@186801|Clostridia,3WHCA@541000|Ruminococcaceae	186801|Clostridia	H	Glutamate-cysteine ligase	gshF	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase,RimK
MMS1_k127_510289_7	401526.TcarDRAFT_2308	2.034e-40	155.0	COG1853@1|root,COG1853@2|Bacteria,1V4IU@1239|Firmicutes,4H4KQ@909932|Negativicutes	909932|Negativicutes	S	PFAM flavin reductase domain protein FMN-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMS1_k127_510289_6	158190.SpiGrapes_1396	3.426e-44	173.0	COG1647@1|root,COG1647@2|Bacteria	2|Bacteria	M	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
MMS1_k127_510289_2	545695.TREAZ_2335	1.997e-102	342.0	COG1313@1|root,COG1313@2|Bacteria,2J68B@203691|Spirochaetes	203691|Spirochaetes	C	Radical SAM domain protein	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMS1_k127_510289_3	158190.SpiGrapes_2766	2.043e-89	300.0	COG0528@1|root,COG0528@2|Bacteria,2J5H9@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS1_k127_510289_4	1123274.KB899410_gene3539	7.799e-63	223.0	COG2834@1|root,COG2834@2|Bacteria,2J7JX@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Outer membrane lipoprotein carrier protein LolA	-	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
MMS1_k127_510289_5	1123274.KB899410_gene3540	1.351e-51	197.0	COG1426@1|root,COG1426@2|Bacteria,2J61E@203691|Spirochaetes	203691|Spirochaetes	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
MMS1_k127_510289_1	665571.STHERM_c21230	2.183e-141	462.0	COG0621@1|root,COG0621@2|Bacteria,2J5PM@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
MMS1_k127_510289_0	1480694.DC28_10065	6.646e-223	711.0	COG0210@1|root,COG0210@2|Bacteria,2J5EW@203691|Spirochaetes	203691|Spirochaetes	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
MMS1_k127_510289_8	760011.Spico_1193	2.634e-30	129.0	COG0001@1|root,COG0001@2|Bacteria,2J60V@203691|Spirochaetes	203691|Spirochaetes	H	glutamate-1-semialdehyde 2,1-aminomutase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_510289_10	573413.Spirs_3755	4.317e-09	61.0	294UB@1|root,2ZS7H@2|Bacteria,2J8RW@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_510289_9	744872.Spica_0467	3.62e-18	84.0	COG0102@1|root,COG0102@2|Bacteria,2J7C1@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS1_k127_511225_2	319224.Sputcn32_0525	1.929e-40	158.0	2F1ZG@1|root,33UYS@2|Bacteria,1NVAI@1224|Proteobacteria,1SN5R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_511225_0	1121472.AQWN01000001_gene215	6.113e-92	312.0	COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,261PN@186807|Peptococcaceae	186801|Clostridia	L	Domain of unknown function (DUF1848)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1848
MMS1_k127_511225_1	1307761.L21SP2_0117	1.422e-67	238.0	COG3694@1|root,COG3694@2|Bacteria,2J7M7@203691|Spirochaetes	203691|Spirochaetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
MMS1_k127_512881_3	573413.Spirs_0468	1.139e-14	77.0	COG0513@1|root,COG0724@1|root,COG0513@2|Bacteria,COG0724@2|Bacteria,2J7A1@203691|Spirochaetes	203691|Spirochaetes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA
MMS1_k127_512881_0	744872.Spica_0276	6.227e-86	300.0	COG2885@1|root,COG2885@2|Bacteria,2J6IG@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	tpn50	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMS1_k127_512881_2	406124.ACPC01000049_gene106	8.47e-17	84.0	COG4405@1|root,COG4405@2|Bacteria,1VDG5@1239|Firmicutes,4HM8P@91061|Bacilli,1ZKFH@1386|Bacillus	91061|Bacilli	S	ASCH	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
MMS1_k127_512881_1	1121439.dsat_1374	1.426e-36	144.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,2MBI8@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
MMS1_k127_512881_4	869213.JCM21142_52162	3.289e-12	72.0	2EFH0@1|root,3399K@2|Bacteria,4NU4T@976|Bacteroidetes	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
MMS1_k127_515233_3	1499967.BAYZ01000069_gene1868	7.658e-27	112.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_515233_0	1499967.BAYZ01000069_gene1867	3.093e-102	341.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K10118,ko:K15771	ko02010,map02010	M00196,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2,3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_515233_1	1499967.BAYZ01000069_gene1866	6.507e-83	289.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_515233_2	1007103.AFHW01000174_gene2475	4.138e-38	160.0	COG5002@1|root,COG5002@2|Bacteria,1UJ5U@1239|Firmicutes,4HG8M@91061|Bacilli,26S07@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA
MMS1_k127_516891_1	573413.Spirs_4056	9.001e-57	206.0	COG1466@1|root,COG1466@2|Bacteria,2J6PN@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
MMS1_k127_516891_0	573413.Spirs_4068	9.047e-191	611.0	COG0322@1|root,COG0322@2|Bacteria,2J69M@203691|Spirochaetes	203691|Spirochaetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
MMS1_k127_518135_2	1320556.AVBP01000011_gene3420	2.337e-08	61.0	COG3447@1|root,COG5001@1|root,COG3447@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TV0G@28211|Alphaproteobacteria,43RVC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_7,PAS_9,dCache_1
MMS1_k127_518135_0	744872.Spica_2498	2.888e-254	797.0	COG2759@1|root,COG2759@2|Bacteria,2J5JZ@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMS1_k127_518135_1	521045.Kole_1123	2.786e-143	465.0	COG0446@1|root,COG0446@2|Bacteria,2GC6J@200918|Thermotogae	200918|Thermotogae	S	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS1_k127_523503_3	665571.STHERM_c11590	8.232e-11	73.0	COG0840@1|root,COG0840@2|Bacteria,2J7RU@203691|Spirochaetes	203691|Spirochaetes	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
MMS1_k127_523503_1	744872.Spica_1655	3.597e-84	291.0	COG2188@1|root,COG2188@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
MMS1_k127_523503_2	1124991.MU9_1020	1.417e-54	194.0	COG2185@1|root,COG2185@2|Bacteria,1RB2M@1224|Proteobacteria,1S2GQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
MMS1_k127_523503_0	1080067.BAZH01000008_gene136	5.928e-113	380.0	COG0849@1|root,COG0849@2|Bacteria,1R40M@1224|Proteobacteria,1RQJ8@1236|Gammaproteobacteria,3WW03@544|Citrobacter	1236|Gammaproteobacteria	D	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
MMS1_k127_524955_3	935948.KE386494_gene930	1.116e-08	60.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,42EQ6@68295|Thermoanaerobacterales	186801|Clostridia	G	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	mglA	-	3.6.3.17	ko:K10542	ko02010,map02010	M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.3	-	-	ABC_tran
MMS1_k127_524955_0	1541960.KQ78_00622	3.35e-143	461.0	COG1879@1|root,COG1879@2|Bacteria,3WUNB@544448|Tenericutes	544448|Tenericutes	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
MMS1_k127_524955_1	1541960.KQ78_00623	4.12e-107	357.0	COG1879@1|root,COG1879@2|Bacteria,3WUR4@544448|Tenericutes	544448|Tenericutes	G	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
MMS1_k127_524955_2	1541960.KQ78_00624	1.207e-15	79.0	COG2972@1|root,COG2972@2|Bacteria,3WUD4@544448|Tenericutes	544448|Tenericutes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase,dCache_1
MMS1_k127_525729_0	1307761.L21SP2_2764	2.725e-220	697.0	COG2217@1|root,COG2217@2|Bacteria,2J60R@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	zntA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS1_k127_526936_0	744872.Spica_1169	2.253e-80	291.0	COG0840@1|root,COG0840@2|Bacteria,2J7VQ@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	mcp-4	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
MMS1_k127_527512_0	573413.Spirs_0987	4.18e-198	623.0	COG0281@1|root,COG0281@2|Bacteria,2J5DN@203691|Spirochaetes	203691|Spirochaetes	C	Malic enzyme, NAD binding domain	mdh	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
MMS1_k127_527512_4	1293054.HSACCH_02195	2.638e-50	186.0	COG1392@1|root,COG1392@2|Bacteria,1USDY@1239|Firmicutes,24Z0E@186801|Clostridia	186801|Clostridia	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
MMS1_k127_527512_2	880073.Calab_1870	2.18e-142	459.0	COG0306@1|root,COG0306@2|Bacteria,2NPA2@2323|unclassified Bacteria	2|Bacteria	U	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
MMS1_k127_527512_6	754027.HMPREF9554_00439	3.332e-22	106.0	COG2186@1|root,COG2186@2|Bacteria,2J8F7@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, GntR family	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,FadR_C,GntR
MMS1_k127_527512_1	596324.TREVI0001_2252	1.566e-160	523.0	COG0579@1|root,COG0579@2|Bacteria,2J68X@203691|Spirochaetes	203691|Spirochaetes	S	BFD-like [2Fe-2S] binding domain	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD
MMS1_k127_527512_3	596324.TREVI0001_2253	7.23e-117	384.0	COG0446@1|root,COG0446@2|Bacteria,2J6N8@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulfide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
MMS1_k127_527512_5	556261.HMPREF0240_01346	1.375e-24	106.0	COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,36M34@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1667
MMS1_k127_527512_7	318464.IO99_08095	5.438e-19	91.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
MMS1_k127_529599_4	237368.SCABRO_02488	4.94e-56	203.0	COG1941@1|root,COG1941@2|Bacteria,2IXWB@203682|Planctomycetes	203682|Planctomycetes	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
MMS1_k127_529599_0	880073.Calab_0420	1.412e-136	447.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
MMS1_k127_529599_6	1249480.B649_09590	3.328e-07	58.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2YP5U@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	hydrogenase maturation protease	hydD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
MMS1_k127_529599_3	573413.Spirs_4219	1.05e-70	241.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
MMS1_k127_529599_2	398512.JQKC01000009_gene538	3.828e-99	333.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,3WGZN@541000|Ruminococcaceae	186801|Clostridia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
MMS1_k127_529599_1	1232436.CAPF01000077_gene1086	8.495e-114	377.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4CUKQ@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
MMS1_k127_529599_5	608538.HTH_1813	6.072e-12	68.0	COG0298@1|root,COG0298@2|Bacteria,2G4DR@200783|Aquificae	200783|Aquificae	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
MMS1_k127_531617_2	443152.MDG893_07420	2.225e-86	297.0	COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,1RNIZ@1236|Gammaproteobacteria,4641C@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0246 Mannitol-1-phosphate altronate dehydrogenases	mtlD	-	1.1.1.57,1.1.1.67,2.7.1.17	ko:K00040,ko:K00045,ko:K00854	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014,M00061	R00868,R01639,R02454	RC00002,RC00085,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
MMS1_k127_531617_1	1195236.CTER_1345	2.026e-136	440.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3WIJA@541000|Ruminococcaceae	186801|Clostridia	G	ABC transporter permease protein	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_531617_0	1195236.CTER_1346	2.16e-156	501.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
MMS1_k127_533544_0	573413.Spirs_0088	5.346e-168	537.0	COG2812@1|root,COG2812@2|Bacteria,2J5A9@203691|Spirochaetes	203691|Spirochaetes	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
MMS1_k127_533544_4	1197906.CAJQ02000027_gene1525	4.207e-06	49.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JV1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
MMS1_k127_533544_3	929713.NIASO_06115	1.827e-10	63.0	COG0448@1|root,COG0448@2|Bacteria,4PKFG@976|Bacteroidetes,1IPMM@117747|Sphingobacteriia	976|Bacteroidetes	G	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
MMS1_k127_538816_2	1123326.JFBL01000003_gene1811	2.98e-108	362.0	COG2223@1|root,COG2223@2|Bacteria,1R22H@1224|Proteobacteria,43DDJ@68525|delta/epsilon subdivisions,2YTID@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_538816_4	273121.WS1007	5.005e-17	82.0	COG2104@1|root,COG2104@2|Bacteria,1NHWM@1224|Proteobacteria,434BQ@68525|delta/epsilon subdivisions,2YSIS@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Sulfur transfer protein involved in thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
MMS1_k127_538816_0	331678.Cphamn1_0644	9.431e-133	434.0	COG2873@1|root,COG2873@2|Bacteria,1FDPZ@1090|Chlorobi	2|Bacteria	H	PFAM Cys Met metabolism pyridoxal-phosphate-dependent	metY-3	-	2.5.1.48,2.5.1.49	ko:K01739,ko:K01740	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
MMS1_k127_538816_1	694427.Palpr_1591	4.464e-121	396.0	COG0476@1|root,COG0476@2|Bacteria,4NFUD@976|Bacteroidetes,2FP9M@200643|Bacteroidia,22XNY@171551|Porphyromonadaceae	976|Bacteroidetes	H	COGs COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2	moeZ	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
MMS1_k127_538816_3	694427.Palpr_1594	5.346e-41	155.0	COG1310@1|root,COG1310@2|Bacteria,4NTI0@976|Bacteroidetes,2FU84@200643|Bacteroidia	976|Bacteroidetes	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
MMS1_k127_538816_5	1280674.AUJK01000006_gene1877	4.537e-06	50.0	COG0155@1|root,COG0425@1|root,COG0155@2|Bacteria,COG0425@2|Bacteria,4NENW@976|Bacteroidetes,2FRDD@200643|Bacteroidia	976|Bacteroidetes	OP	Nitrite and sulphite reductase 4Fe-4S domain	sir	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	HEPN,NIR_SIR,NIR_SIR_ferr
MMS1_k127_54474_1	1480694.DC28_09125	2.628e-14	76.0	COG1640@1|root,COG1640@2|Bacteria,2J62I@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
MMS1_k127_54474_0	545695.TREAZ_2522	2.371e-226	718.0	COG0366@1|root,COG0366@2|Bacteria,2J649@203691|Spirochaetes	203691|Spirochaetes	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
MMS1_k127_545604_1	1163409.UUA_13115	1.549e-91	308.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1X5C0@135614|Xanthomonadales	135614|Xanthomonadales	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
MMS1_k127_545604_0	1294142.CINTURNW_4359	4.806e-93	312.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,36DJS@31979|Clostridiaceae	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
MMS1_k127_552808_1	1304880.JAGB01000002_gene2264	6.871e-16	91.0	2DBSS@1|root,2ZATI@2|Bacteria,1V13H@1239|Firmicutes,24D92@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
MMS1_k127_552808_2	573413.Spirs_1477	1.124e-13	77.0	28Y5G@1|root,2ZK0U@2|Bacteria,2JB1C@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_552808_0	665571.STHERM_c17320	7.894e-129	424.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,2J5CJ@203691|Spirochaetes	203691|Spirochaetes	E	Amino-acid N-acetyltransferase	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
MMS1_k127_552808_3	1159870.KB907784_gene2941	1.686e-09	68.0	COG0834@1|root,COG0834@2|Bacteria,1MVMP@1224|Proteobacteria,2WEI7@28216|Betaproteobacteria	28216|Betaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_554446_1	573413.Spirs_3960	3.148e-129	427.0	COG0517@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0618@2|Bacteria,2J6RC@203691|Spirochaetes	203691|Spirochaetes	S	Domain in cystathionine beta-synthase and other proteins.	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1
MMS1_k127_554446_2	1307761.L21SP2_3066	1.752e-107	361.0	COG2309@1|root,COG2309@2|Bacteria,2J7AX@203691|Spirochaetes	203691|Spirochaetes	E	Aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
MMS1_k127_554446_0	573413.Spirs_0285	1.835e-272	852.0	COG0326@1|root,COG0326@2|Bacteria,2J6JQ@203691|Spirochaetes	203691|Spirochaetes	F	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c_3,HSP90
MMS1_k127_554446_3	1480694.DC28_08400	1.407e-94	319.0	COG1253@1|root,COG1253@2|Bacteria,2J7S9@203691|Spirochaetes	203691|Spirochaetes	P	COGs COG1253 Hemolysins and related protein containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
MMS1_k127_564060_2	1307761.L21SP2_2438	6.645e-33	147.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,SpoIIE,dCache_1
MMS1_k127_564060_0	1307761.L21SP2_2546	1.888e-105	369.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_564060_1	243275.TDE_1102	1.399e-35	143.0	COG0457@1|root,COG0457@2|Bacteria,2J86N@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
MMS1_k127_566756_0	96561.Dole_1761	1.894e-278	868.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2MIT4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Elongation factor Tu domain 2	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_566756_2	1307761.L21SP2_1563	6.112e-25	120.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_566756_3	1167006.UWK_01106	3.732e-11	66.0	COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,42RTX@68525|delta/epsilon subdivisions,2WPGC@28221|Deltaproteobacteria,2MJZX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ACT domain	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
MMS1_k127_575821_3	545694.TREPR_0556	2.18e-49	182.0	COG0488@1|root,COG0488@2|Bacteria,2J5AN@203691|Spirochaetes	203691|Spirochaetes	S	ABC transporter, ATP-binding protein	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
MMS1_k127_575821_2	1307761.L21SP2_2204	8.877e-58	221.0	2F4TS@1|root,33XG8@2|Bacteria,2J5NM@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
MMS1_k127_575821_5	1302858.I871_02050	2.497e-24	113.0	COG2885@1|root,COG2885@2|Bacteria,2J5X0@203691|Spirochaetes	203691|Spirochaetes	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
MMS1_k127_575821_0	573413.Spirs_2858	2.131e-107	367.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2J5H1@203691|Spirochaetes	203691|Spirochaetes	M	Transglycosylase	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
MMS1_k127_575821_1	1123274.KB899412_gene1529	4.801e-79	276.0	COG0457@1|root,COG0457@2|Bacteria,2J5XK@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TPR_8
MMS1_k127_575821_4	936140.AEOT01000027_gene1200	6.823e-38	155.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,4HGWM@91061|Bacilli,3F41U@33958|Lactobacillaceae	91061|Bacilli	LU	DNA protecting protein DprA	dprA	GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
MMS1_k127_575821_6	573413.Spirs_2854	6.512e-16	84.0	28VUA@1|root,2ZHVZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_575821_7	221027.JO40_11515	2.793e-14	78.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2J570@203691|Spirochaetes	203691|Spirochaetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
MMS1_k127_578769_0	862908.BMS_0376	8.438e-30	127.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2MU5M@213481|Bdellovibrionales,2WJWT@28221|Deltaproteobacteria	213481|Bdellovibrionales	M	Sugar transferase	-	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
MMS1_k127_578769_1	545695.TREAZ_0666	0.0009127	49.0	2F1XI@1|root,33UX3@2|Bacteria,2J59N@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_585572_0	1280390.CBQR020000054_gene1064	6.144e-155	495.0	COG1653@1|root,COG1653@2|Bacteria,1UY8X@1239|Firmicutes,4HT5T@91061|Bacilli,26RVV@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K10232	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1
MMS1_k127_585572_2	621372.ACIH01000113_gene896	3.868e-107	358.0	COG1175@1|root,COG1175@2|Bacteria,1VTEM@1239|Firmicutes,4HU1Z@91061|Bacilli,26TBH@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
MMS1_k127_585572_1	1274374.CBLK010000003_gene3218	3.883e-120	396.0	COG0395@1|root,COG0395@2|Bacteria,1V1TN@1239|Firmicutes,4HU3Z@91061|Bacilli,26RTQ@186822|Paenibacillaceae	91061|Bacilli	G	Sugar ABC transporter permease	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
MMS1_k127_585572_3	1173024.KI912151_gene2144	6.593e-68	239.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1G0DN@1117|Cyanobacteria,1JIES@1189|Stigonemataceae	1117|Cyanobacteria	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
MMS1_k127_585572_5	31234.CRE17699	1.919e-19	101.0	COG1409@1|root,KOG1378@2759|Eukaryota,38RDT@33154|Opisthokonta,3CGFG@33208|Metazoa,3DXX3@33213|Bilateria,40J5M@6231|Nematoda,1M2GN@119089|Chromadorea,40X1F@6236|Rhabditida	33208|Metazoa	G	Iron/zinc purple acid phosphatase-like protein C	-	-	-	ko:K22390	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_C,Pur_ac_phosph_N
MMS1_k127_585572_4	1123274.KB899416_gene2603	6.46e-51	183.0	COG0406@1|root,COG0406@2|Bacteria,2J97K@203691|Spirochaetes	203691|Spirochaetes	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
MMS1_k127_597128_2	1280664.AUIX01000015_gene2280	1.752e-16	85.0	COG3173@1|root,COG3173@2|Bacteria,1U6NE@1239|Firmicutes,2489R@186801|Clostridia,4BXXB@830|Butyrivibrio	186801|Clostridia	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMS1_k127_597128_3	1033732.CAHI01000006_gene2195	4.287e-07	53.0	COG0180@1|root,COG0180@2|Bacteria,4NETX@976|Bacteroidetes,2FMAT@200643|Bacteroidia,22UVK@171550|Rikenellaceae	976|Bacteroidetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS1_k127_597128_4	1178825.ALIH01000002_gene1015	0.0008198	50.0	COG0454@1|root,COG0456@2|Bacteria,4NH5K@976|Bacteroidetes,1I25M@117743|Flavobacteriia	976|Bacteroidetes	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
MMS1_k127_597128_0	1121904.ARBP01000004_gene802	0.0	1399.0	COG2373@1|root,COG2373@2|Bacteria,4NEW9@976|Bacteroidetes,47MDC@768503|Cytophagia	976|Bacteroidetes	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
MMS1_k127_597128_1	457424.BFAG_00636	2.633e-53	194.0	COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,2FNUH@200643|Bacteroidia,4AMUJ@815|Bacteroidaceae	976|Bacteroidetes	M	COG4953 Membrane carboxypeptidase penicillin-binding protein PbpC	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
MMS1_k127_597363_2	1273538.G159_12030	6.615e-17	83.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,4HA95@91061|Bacilli,26DIJ@186818|Planococcaceae	91061|Bacilli	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1,5.1.1.5	ko:K01775,ko:K20707	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
MMS1_k127_597363_1	1121382.JQKG01000033_gene3119	1.542e-33	141.0	COG3570@1|root,COG3570@2|Bacteria	2|Bacteria	V	aminoglycoside hydroxyurea antibiotic resistance kinase	strB	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
MMS1_k127_597363_0	1307761.L21SP2_1024	2.263e-89	298.0	COG0549@1|root,COG0549@2|Bacteria,2J64E@203691|Spirochaetes	203691|Spirochaetes	E	Belongs to the carbamate kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS1_k127_597848_0	933262.AXAM01000118_gene2901	1.44e-39	167.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,2MHPX@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
MMS1_k127_598480_6	1033737.CAEV01000081_gene14	2.984e-37	149.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,36FB9@31979|Clostridiaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_598480_5	158190.SpiGrapes_2213	3.55e-67	243.0	2EG9W@1|root,33A1P@2|Bacteria,2J9F9@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_598480_4	158189.SpiBuddy_2777	2.414e-83	283.0	COG2834@1|root,COG2834@2|Bacteria,2J7Z0@203691|Spirochaetes	203691|Spirochaetes	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_598480_1	158190.SpiGrapes_2215	6.958e-147	475.0	COG4591@1|root,COG4591@2|Bacteria,2JA02@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_598480_0	158190.SpiGrapes_2216	3.182e-168	537.0	COG4591@1|root,COG4591@2|Bacteria,2J7QZ@203691|Spirochaetes	203691|Spirochaetes	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_598480_3	158189.SpiBuddy_2774	1.483e-106	349.0	COG1136@1|root,COG1136@2|Bacteria,2J7FN@203691|Spirochaetes	203691|Spirochaetes	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_598480_2	158189.SpiBuddy_2773	2.421e-112	368.0	COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes	203691|Spirochaetes	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS1_k127_599334_8	1365176.N186_05280	2.438e-06	49.0	COG0494@1|root,arCOG01074@2157|Archaea,2XS5U@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
MMS1_k127_599334_5	1232410.KI421413_gene869	4.101e-31	133.0	COG1192@1|root,COG1192@2|Bacteria,1QWQB@1224|Proteobacteria,42T6R@68525|delta/epsilon subdivisions,2WP6A@28221|Deltaproteobacteria,43T53@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Involved in chromosome partitioning	pcmW	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_599334_3	1121904.ARBP01000011_gene1433	3.067e-72	251.0	2DBF0@1|root,2Z8VT@2|Bacteria,4NECW@976|Bacteroidetes	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
MMS1_k127_599334_6	744872.Spica_2653	6.46e-24	104.0	COG4496@1|root,COG4496@2|Bacteria,2J8GD@203691|Spirochaetes	203691|Spirochaetes	S	trp operon repressor	-	-	-	ko:K03720	-	-	-	-	ko00000,ko03000	-	-	-	Trp_repressor
MMS1_k127_599334_9	523791.Kkor_1779	0.0007114	47.0	COG2900@1|root,COG2900@2|Bacteria	2|Bacteria	S	Belongs to the SlyX family	slyX	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
MMS1_k127_599334_0	1123274.KB899428_gene1825	9.048e-206	650.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	rrp-2	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_599334_1	1480694.DC28_14145	2.793e-114	380.0	COG5000@1|root,COG5000@2|Bacteria,2J5RG@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
MMS1_k127_599334_4	1307761.L21SP2_0920	1.198e-63	233.0	COG0470@1|root,COG0470@2|Bacteria,2JBGE@203691|Spirochaetes	203691|Spirochaetes	L	DNA polymerase III, delta subunit	-	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
MMS1_k127_599334_7	1304888.ATWF01000001_gene1085	5.374e-08	61.0	COG1286@1|root,COG1286@2|Bacteria,2GFTX@200930|Deferribacteres	200930|Deferribacteres	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
MMS1_k127_599334_2	573413.Spirs_1705	3.639e-87	298.0	COG0707@1|root,COG0707@2|Bacteria,2J5XF@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
MMS1_k127_599966_1	522772.Dacet_0976	1.67e-41	161.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	DnaJ
MMS1_k127_599966_0	1121017.AUFG01000032_gene408	3.067e-135	439.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4FEXR@85021|Intrasporangiaceae	201174|Actinobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMS1_k127_602007_1	1353529.M899_3479	4.357e-50	182.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2MT3K@213481|Bdellovibrionales,2WPHH@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
MMS1_k127_602007_0	1131462.DCF50_p2192	6.96e-90	312.0	COG0286@1|root,COG0286@2|Bacteria,1UMSN@1239|Firmicutes,24856@186801|Clostridia,260P4@186807|Peptococcaceae	186801|Clostridia	V	N-6 DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,N6_Mtase,TaqI_C
MMS1_k127_602918_1	1265505.ATUG01000001_gene4499	2.122e-113	386.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WJBK@28221|Deltaproteobacteria,2MHTB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_602918_5	1340493.JNIF01000004_gene856	9.743e-10	61.0	COG0745@1|root,COG0745@2|Bacteria	1340493.JNIF01000004_gene856|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_602918_2	1125700.HMPREF9195_01534	1.007e-55	198.0	COG1327@1|root,COG1327@2|Bacteria,2J7FW@203691|Spirochaetes	203691|Spirochaetes	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
MMS1_k127_602918_0	596324.TREVI0001_2302	0.0	1033.0	COG1328@1|root,COG1328@2|Bacteria,2J5H0@203691|Spirochaetes	203691|Spirochaetes	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
MMS1_k127_602918_4	1410609.JHVB01000001_gene1792	1.884e-31	130.0	COG0526@1|root,COG0526@2|Bacteria,2J6EG@203691|Spirochaetes	203691|Spirochaetes	CO	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin,NRDD
MMS1_k127_602918_3	742733.HMPREF9469_05609	2.885e-44	167.0	COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,21Z2G@1506553|Lachnoclostridium	186801|Clostridia	O	anaerobic ribonucleoside-triphosphate reductase activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMS1_k127_60391_0	665571.STHERM_c03590	6.351e-131	428.0	COG3044@1|root,COG3044@2|Bacteria	2|Bacteria	S	Predicted ATPase of the ABC class	-	-	-	-	-	-	-	-	-	-	-	-	ABC_ATPase
MMS1_k127_60391_1	1123274.KB899420_gene4054	2.371e-89	303.0	COG1145@1|root,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_60391_2	391295.SSU05_1560	1.111e-07	55.0	COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,4HA5R@91061|Bacilli,1WSFF@1307|Streptococcus suis	91061|Bacilli	G	Melibiase	aga	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
MMS1_k127_603916_1	1191523.MROS_1274	2.704e-32	128.0	COG1393@1|root,COG1393@2|Bacteria	2|Bacteria	P	arsenate reductase (glutaredoxin) activity	arsC1	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC,Glutaredoxin
MMS1_k127_603916_0	573413.Spirs_2246	7.19e-68	240.0	COG1235@1|root,COG1235@2|Bacteria,2JAK8@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMS1_k127_606114_1	867903.ThesuDRAFT_01077	1.259e-101	338.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WCYH@538999|Clostridiales incertae sedis	186801|Clostridia	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS1_k127_606114_2	639282.DEFDS_2066	4.172e-97	325.0	COG1173@1|root,COG1173@2|Bacteria,2GF47@200930|Deferribacteres	2|Bacteria	P	Peptide nickel ABC transporter, permease	dppC	-	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS1_k127_606114_0	207559.Dde_1184	2.014e-110	366.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria,2MG57@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033,ko:K12369	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS1_k127_606114_3	639282.DEFDS_2068	1.623e-50	183.0	COG0747@1|root,COG0747@2|Bacteria,2GEIN@200930|Deferribacteres	2|Bacteria	E	Peptide nickel ABC transporter, substrate-binding protein	dppA	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363	-	ko:K02035,ko:K12368,ko:K19226	ko01503,ko02010,ko02024,ko02030,map01503,map02010,map02024,map02030	M00239,M00324,M00739	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.5	-	iSSON_1240.SSON_3846	SBP_bac_5
MMS1_k127_608278_0	324602.Caur_1156	1.942e-242	762.0	COG0747@1|root,COG0747@2|Bacteria,2G7TA@200795|Chloroflexi,377H7@32061|Chloroflexia	32061|Chloroflexia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS1_k127_608278_3	1208321.D104_11800	1.99e-31	132.0	COG1309@1|root,COG1309@2|Bacteria,1NMHE@1224|Proteobacteria	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_608278_2	573413.Spirs_3424	1.061e-135	439.0	COG1879@1|root,COG1879@2|Bacteria,2J5KN@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Peripla_BP_4
MMS1_k127_608278_1	158189.SpiBuddy_2446	3.711e-181	582.0	COG2972@1|root,COG2972@2|Bacteria,2J59G@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
MMS1_k127_611030_2	158189.SpiBuddy_2605	1.367e-162	514.0	COG1878@1|root,COG1878@2|Bacteria,2JA18@203691|Spirochaetes	203691|Spirochaetes	I	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
MMS1_k127_611030_4	158189.SpiBuddy_2604	1.77e-112	366.0	2ATRB@1|root,31JA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_611030_0	158189.SpiBuddy_2603	8.945e-188	593.0	COG0183@1|root,COG0183@2|Bacteria,2JBB9@203691|Spirochaetes	203691|Spirochaetes	I	Thiolase, C-terminal domain	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_611030_8	744872.Spica_0612	2.12e-39	151.0	COG1545@1|root,COG1545@2|Bacteria,2JAEJ@203691|Spirochaetes	203691|Spirochaetes	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	-
MMS1_k127_611030_7	913865.DOT_3610	2.954e-80	278.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,24DRF@186801|Clostridia,2646E@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_611030_9	1487923.DP73_12470	3.409e-22	98.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,24DRF@186801|Clostridia,2646E@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_611030_5	913865.DOT_3609	5.602e-99	331.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,26193@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_611030_6	1313172.YM304_01530	1.123e-88	303.0	COG1744@1|root,COG1744@2|Bacteria,2IEKS@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	-	-	-	-	-	-	-	-	-	Bmp
MMS1_k127_611030_1	693661.Arcve_0450	1.129e-164	532.0	COG3845@1|root,arCOG00186@2157|Archaea,2XUEG@28890|Euryarchaeota	28890|Euryarchaeota	E	transport systems ATPase components	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
MMS1_k127_611030_3	1384057.CD33_01940	3.843e-137	442.0	COG1680@1|root,COG1680@2|Bacteria,1TR9E@1239|Firmicutes,4HER8@91061|Bacilli,3IWEK@400634|Lysinibacillus	91061|Bacilli	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
MMS1_k127_611133_0	573413.Spirs_3939	5.726e-90	308.0	COG0128@1|root,COG0128@2|Bacteria,2J6P5@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS1_k127_611133_1	642492.Clole_0658	3.85e-10	69.0	COG3210@1|root,COG4733@1|root,COG3210@2|Bacteria,COG4733@2|Bacteria,1TR9M@1239|Firmicutes,24BEI@186801|Clostridia	186801|Clostridia	U	S-layer domain-containing protein	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Flg_new,SLH
MMS1_k127_611871_1	349521.HCH_04161	1.493e-53	196.0	COG0834@1|root,COG0834@2|Bacteria,1RDZV@1224|Proteobacteria,1S4VJ@1236|Gammaproteobacteria,1XKQX@135619|Oceanospirillales	135619|Oceanospirillales	ET	ABC-type amino acid transport signal transduction systems, periplasmic component domain	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
MMS1_k127_611871_0	1165841.SULAR_07920	1.914e-62	231.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43CPN@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,NMT1,dCache_1,dCache_3
MMS1_k127_613695_2	2002.JOEQ01000024_gene118	2.258e-13	71.0	COG4573@1|root,COG4573@2|Bacteria,2IAVH@201174|Actinobacteria	201174|Actinobacteria	G	Tagatose 6 phosphate kinase	-	-	-	ko:K16371	ko00052,ko01100,map00052,map01100	-	R01069	RC00438,RC00439	ko00000,ko00001	-	-	-	Tagatose_6_P_K
MMS1_k127_613695_1	545695.TREAZ_3085	6.488e-59	207.0	COG4154@1|root,COG4154@2|Bacteria,2J8CF@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the RbsD FucU family	-	-	5.1.3.29	ko:K02431	-	-	R10764	RC00563	ko00000,ko01000	-	-	-	RbsD_FucU
MMS1_k127_613695_0	794903.OPIT5_17300	4.372e-93	310.0	COG0656@1|root,COG0656@2|Bacteria,46XFN@74201|Verrucomicrobia,3K9CQ@414999|Opitutae	414999|Opitutae	S	Aldo/keto reductase family	-	-	1.1.1.2	ko:K00002	ko00010,ko00040,ko00561,ko00930,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00561,map00930,map01100,map01110,map01120,map01130,map01220	M00014	R00746,R01041,R01481,R05231	RC00087,RC00088,RC00099,RC00108	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Aldo_ket_red
MMS1_k127_614044_2	573413.Spirs_0325	7.347e-95	312.0	COG0664@1|root,COG0664@2|Bacteria,2J6CX@203691|Spirochaetes	203691|Spirochaetes	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_614044_4	545694.TREPR_0768	5.325e-49	180.0	COG0597@1|root,COG0597@2|Bacteria,2J7QV@203691|Spirochaetes	203691|Spirochaetes	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
MMS1_k127_614044_3	1480694.DC28_09940	1.234e-86	293.0	COG0327@1|root,COG0327@2|Bacteria,2J6QQ@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM dinuclear metal center protein, YbgI SA1388 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
MMS1_k127_614044_0	1123274.KB899407_gene184	2.154e-220	709.0	COG0606@1|root,COG1067@1|root,COG0606@2|Bacteria,COG1067@2|Bacteria,2J6SU@203691|Spirochaetes	203691|Spirochaetes	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
MMS1_k127_614044_1	573413.Spirs_0320	5.518e-116	380.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_615668_0	665571.STHERM_c01070	4.624e-143	470.0	COG2114@1|root,COG2114@2|Bacteria,2J6Q9@203691|Spirochaetes	203691|Spirochaetes	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP,Response_reg
MMS1_k127_615668_2	889378.Spiaf_1312	1.118e-32	133.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_615668_4	889378.Spiaf_2310	1.054e-21	99.0	298IC@1|root,2ZVPA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_615668_3	744872.Spica_1877	8.232e-27	111.0	COG0864@1|root,COG0864@2|Bacteria,2J98M@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	NikR_C
MMS1_k127_615668_1	177437.HRM2_01520	3.227e-113	374.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,42MFS@68525|delta/epsilon subdivisions,2WJPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Fumarate lyase	-	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS1_k127_615798_0	1304880.JAGB01000004_gene1379	6.682e-219	700.0	COG1554@1|root,COG1554@2|Bacteria,1UYXZ@1239|Firmicutes,249HP@186801|Clostridia	186801|Clostridia	G	hydrolase, family 65, central catalytic	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_615798_3	158189.SpiBuddy_1577	4.893e-119	389.0	COG3507@1|root,COG3507@2|Bacteria,2J7GP@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
MMS1_k127_615798_1	158189.SpiBuddy_1515	4.804e-210	663.0	COG1653@1|root,COG1653@2|Bacteria,2J9SB@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_615798_2	158189.SpiBuddy_1516	1.273e-148	472.0	COG0395@1|root,COG0395@2|Bacteria,2J9WE@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_623141_5	933262.AXAM01000080_gene2313	1.142e-76	268.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,42Q61@68525|delta/epsilon subdivisions,2WM4W@28221|Deltaproteobacteria,2MJEU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_623141_7	1122604.JONR01000001_gene1908	3.189e-55	201.0	COG5495@1|root,COG5495@2|Bacteria,1N50Y@1224|Proteobacteria,1SBC4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520
MMS1_k127_623141_3	765869.BDW_13115	2.185e-92	321.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2MSX4@213481|Bdellovibrionales,2WIQK@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
MMS1_k127_623141_4	1410609.JHVB01000005_gene1279	7.057e-89	299.0	COG0414@1|root,COG0414@2|Bacteria,2J6UH@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
MMS1_k127_623141_8	665571.STHERM_c02120	1.027e-53	194.0	COG0452@1|root,COG0452@2|Bacteria,2J5EB@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS1_k127_623141_10	765869.BDW_13125	1.117e-35	149.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2MT56@213481|Bdellovibrionales,2WIR1@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS1_k127_623141_2	945713.IALB_0060	2.916e-101	335.0	COG1521@1|root,COG1521@2|Bacteria	2|Bacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
MMS1_k127_623141_9	857293.CAAU_0954	1.099e-40	153.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,36K0M@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
MMS1_k127_623141_0	573413.Spirs_3433	6.979e-194	632.0	COG0840@1|root,COG1145@1|root,COG4624@1|root,COG0840@2|Bacteria,COG1145@2|Bacteria,COG4624@2|Bacteria,2J5UI@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,MCPsignal
MMS1_k127_623141_6	1307761.L21SP2_2865	4.92e-61	222.0	COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,2J8FW@203691|Spirochaetes	203691|Spirochaetes	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C,GGDEF,Response_reg
MMS1_k127_623141_1	1123371.ATXH01000003_gene1954	2.509e-110	367.0	COG0226@1|root,COG0226@2|Bacteria,2GGVR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS1_k127_623141_11	909663.KI867150_gene309	4.592e-29	123.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WK67@28221|Deltaproteobacteria,2MRPU@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iAF987.Gmet_2702	BPD_transp_1
MMS1_k127_623222_1	1121087.AUCK01000020_gene2098	4.975e-118	392.0	COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,4HA5R@91061|Bacilli,1ZBRR@1386|Bacillus	91061|Bacilli	G	Alpha-galactosidase	aga	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_36C,Glyco_hydro_36N,Melibiase
MMS1_k127_623222_0	926561.KB900617_gene1574	2.567e-137	443.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,3WBDQ@53433|Halanaerobiales	186801|Clostridia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	HTS
MMS1_k127_623222_2	1120973.AQXL01000121_gene107	7.735e-14	72.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,4HHRQ@91061|Bacilli,279R7@186823|Alicyclobacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	glxII	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
MMS1_k127_625068_5	439235.Dalk_2532	6.363e-27	112.0	COG1996@1|root,COG1996@2|Bacteria,1QV33@1224|Proteobacteria,43CNA@68525|delta/epsilon subdivisions,2X7VK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_625068_4	1541959.KQ51_00260	4.087e-48	186.0	2E6H4@1|root,3314B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_625068_1	880073.Calab_3217	6.799e-169	554.0	COG1472@1|root,COG1472@2|Bacteria,2NNR4@2323|unclassified Bacteria	2|Bacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
MMS1_k127_625068_3	243090.RB680	1.808e-65	233.0	COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,2J1WF@203682|Planctomycetes	203682|Planctomycetes	K	AraC-like ligand binding domain	-	-	-	ko:K02854	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_18
MMS1_k127_625068_0	385682.AFSL01000072_gene1340	3.693e-177	563.0	COG4806@1|root,COG4806@2|Bacteria,4NHKW@976|Bacteroidetes,2FNVS@200643|Bacteroidia	976|Bacteroidetes	G	Psort location Cytoplasmic, score 8.96	rhaA	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008740,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019299,GO:0019301,GO:0019318,GO:0019320,GO:0019321,GO:0019324,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	5.3.1.14	ko:K01813	ko00051,ko01120,map00051,map01120	-	R02437	RC00434	ko00000,ko00001,ko01000	-	-	-	RhaA
MMS1_k127_625068_2	545695.TREAZ_3442	9.044e-105	351.0	COG3347@1|root,COG3347@2|Bacteria,2J7D3@203691|Spirochaetes	203691|Spirochaetes	IQ	PFAM Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
MMS1_k127_626064_5	886882.PPSC2_p0055	2.891e-14	75.0	COG1896@1|root,COG1896@2|Bacteria	2|Bacteria	S	5'-deoxynucleotidase activity	-	-	-	ko:K07023	-	-	-	-	ko00000	-	-	-	HD_3
MMS1_k127_626064_1	1307761.L21SP2_2408	8.483e-114	374.0	28Q26@1|root,2ZCKA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_626064_2	1268239.PALB_13510	4.952e-86	299.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2Q1AE@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	T	COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
MMS1_k127_626064_0	485916.Dtox_0871	0.0	1180.0	COG0376@1|root,COG0376@2|Bacteria,1TQDA@1239|Firmicutes,24DM7@186801|Clostridia,260RF@186807|Peptococcaceae	186801|Clostridia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
MMS1_k127_626064_4	1307761.L21SP2_3384	7.146e-30	123.0	COG2832@1|root,COG2832@2|Bacteria,2J99C@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF454)	-	-	-	ko:K09790	-	-	-	-	ko00000	-	-	-	DUF454
MMS1_k127_626064_3	1166018.FAES_4361	2.855e-34	136.0	COG0583@1|root,COG0583@2|Bacteria,4NGZ5@976|Bacteroidetes,47JGK@768503|Cytophagia	976|Bacteroidetes	K	Bacterial regulatory helix-turn-helix protein, lysR family	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
MMS1_k127_626536_0	338963.Pcar_1355	6.66e-141	474.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,43STW@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CZB,HAMP,MCPsignal,dCache_1,dCache_3,sCache_2
MMS1_k127_626536_1	1195236.CTER_3388	1.341e-05	53.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WH05@541000|Ruminococcaceae	186801|Clostridia	NT	Signal transducing histidine kinase homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
MMS1_k127_626729_2	744872.Spica_0197	8.42e-35	138.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,2J58N@203691|Spirochaetes	203691|Spirochaetes	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
MMS1_k127_626729_0	573413.Spirs_4298	2.383e-170	545.0	COG1066@1|root,COG1066@2|Bacteria,2J5WN@203691|Spirochaetes	203691|Spirochaetes	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
MMS1_k127_626729_1	889378.Spiaf_2751	1.43e-60	214.0	COG1916@1|root,COG1916@2|Bacteria,2J5K2@203691|Spirochaetes	203691|Spirochaetes	S	Pheromone shutdown protein	traB	-	-	-	-	-	-	-	-	-	-	-	TraB
MMS1_k127_6288_0	717606.PaecuDRAFT_3958	2.361e-67	243.0	COG0477@1|root,COG2814@2|Bacteria,1UYJQ@1239|Firmicutes,4HCAW@91061|Bacilli,277ER@186822|Paenibacillaceae	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_645060_0	1121403.AUCV01000001_gene736	1.946e-188	594.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,42PYN@68525|delta/epsilon subdivisions,2WS4X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS1_k127_645060_1	1485544.JQKP01000001_gene927	5.924e-36	143.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,44V3D@713636|Nitrosomonadales	28216|Betaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS1_k127_645060_2	1260251.SPISAL_00210	1.483e-05	47.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales	135613|Chromatiales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS1_k127_646987_4	1408424.JHYI01000043_gene2884	2.668e-123	402.0	COG3940@1|root,COG3940@2|Bacteria,1TRHI@1239|Firmicutes,4H9PB@91061|Bacilli,1ZAW1@1386|Bacillus	91061|Bacilli	G	Glycosyl hydrolases family 43	abf2	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
MMS1_k127_646987_5	573061.Clocel_1251	2.798e-113	373.0	COG4189@1|root,COG4189@2|Bacteria,1TPGD@1239|Firmicutes,248UW@186801|Clostridia,36EKR@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS1_k127_646987_3	665571.STHERM_c14740	3.383e-135	441.0	COG3507@1|root,COG3507@2|Bacteria,2JAU1@203691|Spirochaetes	203691|Spirochaetes	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
MMS1_k127_646987_1	515635.Dtur_1732	3.483e-181	575.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
MMS1_k127_646987_2	515635.Dtur_1731	4.084e-138	444.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K10109,ko:K10118,ko:K10189,ko:K15771,ko:K17316	ko02010,map02010	M00194,M00196,M00199,M00207,M00491,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22,3.A.1.1.24,3.A.1.1.28,3.A.1.1.30,3.A.1.1.4	-	-	BPD_transp_1,TM_PBP2_N
MMS1_k127_646987_6	515635.Dtur_1730	5.608e-109	360.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_646987_0	1449050.JNLE01000003_gene2852	1.176e-227	723.0	COG3533@1|root,COG3533@2|Bacteria,1TRI1@1239|Firmicutes,248CA@186801|Clostridia,36GVY@31979|Clostridiaceae	186801|Clostridia	N	Glucan endo-1,3-beta-glucosidase K09955	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	DUF4986,Glyco_hydro_127
MMS1_k127_648957_5	1304885.AUEY01000050_gene1187	2.195e-88	315.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_648957_6	665571.STHERM_c20830	5.459e-48	179.0	COG0494@1|root,COG0494@2|Bacteria,2J7P7@203691|Spirochaetes	203691|Spirochaetes	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_648957_4	889378.Spiaf_1666	2.766e-101	341.0	COG1509@1|root,COG1509@2|Bacteria,2J6VS@203691|Spirochaetes	203691|Spirochaetes	C	TIGRFAM KamA family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
MMS1_k127_648957_2	1307761.L21SP2_0293	1.007e-109	363.0	COG1045@1|root,COG1045@2|Bacteria,2J73S@203691|Spirochaetes	203691|Spirochaetes	E	Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
MMS1_k127_648957_0	665571.STHERM_c21330	3.162e-173	563.0	COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,2J6QT@203691|Spirochaetes	203691|Spirochaetes	EGT	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,PTS_EIIA_2
MMS1_k127_648957_3	1540257.JQMW01000011_gene2358	1.111e-105	356.0	COG0477@1|root,COG2814@2|Bacteria,1UZKT@1239|Firmicutes,25EHZ@186801|Clostridia,36HPP@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_648957_1	411477.PARMER_01990	4.233e-153	493.0	COG1760@1|root,COG1760@2|Bacteria,4NENR@976|Bacteroidetes,2FMVE@200643|Bacteroidia,22W9U@171551|Porphyromonadaceae	976|Bacteroidetes	E	Serine dehydratase	sdaA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
MMS1_k127_648957_7	665942.HMPREF1022_02224	4.814e-09	60.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2M9Z3@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_650562_1	312309.VF_0977	3.739e-32	130.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1XXMX@135623|Vibrionales	135623|Vibrionales	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
MMS1_k127_650562_0	521674.Plim_0595	2.897e-61	220.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
MMS1_k127_653743_4	1480694.DC28_10755	3.376e-46	179.0	COG1235@1|root,COG2905@1|root,COG1235@2|Bacteria,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin,Lactamase_B,Lactamase_B_2,cNMP_binding
MMS1_k127_653743_2	1480694.DC28_01000	3.027e-92	311.0	COG1234@1|root,COG1234@2|Bacteria,2J7K3@203691|Spirochaetes	203691|Spirochaetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_653743_1	158190.SpiGrapes_1058	1.039e-191	606.0	COG2509@1|root,COG2509@2|Bacteria,2J6ED@203691|Spirochaetes	203691|Spirochaetes	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	Pyr_redox_2
MMS1_k127_653743_0	1121129.KB903359_gene1916	8.598e-209	662.0	COG4108@1|root,COG4108@2|Bacteria,4NFEZ@976|Bacteroidetes,2FN0A@200643|Bacteroidia,22W67@171551|Porphyromonadaceae	976|Bacteroidetes	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,RF3_C
MMS1_k127_653743_3	1499967.BAYZ01000095_gene4262	4.361e-62	222.0	COG1102@1|root,COG1102@2|Bacteria,2NRB0@2323|unclassified Bacteria	2|Bacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
MMS1_k127_655474_2	1173027.Mic7113_2318	4.984e-14	74.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria,1H8X5@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_655474_0	1123274.KB899414_gene3625	2.851e-279	868.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2J5JF@203691|Spirochaetes	203691|Spirochaetes	C	Oxaloacetate decarboxylase, alpha subunit	oadA	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
MMS1_k127_655474_1	391603.FBALC1_09162	8.654e-162	528.0	COG0612@1|root,COG0612@2|Bacteria,4NDXM@976|Bacteroidetes,1HYCC@117743|Flavobacteriia	976|Bacteroidetes	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS1_k127_656861_4	1033737.CAEV01000074_gene457	3.494e-09	63.0	COG1011@1|root,COG1011@2|Bacteria,1UNJF@1239|Firmicutes,24HG6@186801|Clostridia	186801|Clostridia	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMS1_k127_656861_1	1410650.JHWL01000001_gene1127	2.2e-148	479.0	COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,24806@186801|Clostridia,4BWWU@830|Butyrivibrio	186801|Clostridia	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
MMS1_k127_656861_2	1408422.JHYF01000004_gene1569	2.25e-73	259.0	COG1082@1|root,COG1082@2|Bacteria,1U81K@1239|Firmicutes,2492P@186801|Clostridia,36EQ6@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMS1_k127_656861_0	1396141.BATP01000012_gene2705	1.917e-154	501.0	COG3507@1|root,COG3507@2|Bacteria,46UI1@74201|Verrucomicrobia,2IVMS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
MMS1_k127_656861_3	1121335.Clst_0909	6.083e-31	125.0	COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,24A0R@186801|Clostridia,3WI0S@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the glycosyl hydrolase 28 family	-	-	3.2.1.67	ko:K01213	ko00040,ko01100,map00040,map01100	M00081	R01982,R07413	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_28,Pectate_lyase_3
MMS1_k127_657018_0	1480694.DC28_08505	6.734e-176	567.0	COG2114@1|root,COG2114@2|Bacteria,2J77D@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
MMS1_k127_657018_3	1480694.DC28_08495	9.197e-06	57.0	2A8S1@1|root,30XUQ@2|Bacteria,2JB58@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_657018_1	573413.Spirs_0058	4.551e-51	205.0	COG0840@1|root,COG0840@2|Bacteria,2J5BF@203691|Spirochaetes	203691|Spirochaetes	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_657018_2	351160.RCIX1231	2.959e-07	56.0	COG2202@1|root,arCOG06721@1|root,arCOG06721@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3,PAS_4,PAS_9,PocR
MMS1_k127_657629_0	1168289.AJKI01000030_gene1186	6.205e-129	415.0	COG1509@1|root,COG1509@2|Bacteria,4NJ79@976|Bacteroidetes,2G2FM@200643|Bacteroidia,3XJK2@558415|Marinilabiliaceae	976|Bacteroidetes	E	Lysine-2,3-aminomutase	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
MMS1_k127_657629_1	665571.STHERM_c20960	1.273e-82	299.0	COG2207@1|root,COG2207@2|Bacteria,2J6IS@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18
MMS1_k127_657866_0	350688.Clos_2540	9.373e-115	376.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,36EAA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
MMS1_k127_657866_1	1121324.CLIT_4c00950	4.099e-50	183.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,25QQU@186804|Peptostreptococcaceae	186801|Clostridia	P	ABC transporter permease	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
MMS1_k127_658822_0	889378.Spiaf_1612	1.528e-57	219.0	2F8XC@1|root,34196@2|Bacteria,2J6EN@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_658822_1	573413.Spirs_2422	9.968e-55	198.0	COG0618@1|root,COG0618@2|Bacteria,2J74X@203691|Spirochaetes	203691|Spirochaetes	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
MMS1_k127_663050_2	1123504.JQKD01000040_gene2819	2.212e-84	289.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2VIAK@28216|Betaproteobacteria,4ABRU@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, AraC family	ada	GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,HTH_AraC,Methyltransf_1N
MMS1_k127_663050_0	319795.Dgeo_2821	7.341e-108	364.0	COG1653@1|root,COG1653@2|Bacteria,1WJQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_663050_3	1007103.AFHW01000184_gene731	1.405e-82	284.0	COG1175@1|root,COG1175@2|Bacteria,1V109@1239|Firmicutes,4HC5A@91061|Bacilli,26UKR@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_663050_1	573413.Spirs_3597	1.943e-84	287.0	COG0395@1|root,COG0395@2|Bacteria,2J6HM@203691|Spirochaetes	203691|Spirochaetes	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_665649_0	1144325.PMI22_04724	1.179e-88	312.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
MMS1_k127_665843_1	1499689.CCNN01000007_gene1157	1.796e-24	104.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_665843_0	742735.HMPREF9467_00906	1.471e-68	256.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,21YNA@1506553|Lachnoclostridium	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
MMS1_k127_665843_2	744872.Spica_0938	4.15e-13	70.0	COG1396@1|root,COG1396@2|Bacteria,2J70F@203691|Spirochaetes	203691|Spirochaetes	K	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
MMS1_k127_675157_1	478749.BRYFOR_06085	3.046e-80	276.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_675157_0	1280676.AUJO01000006_gene656	1.377e-104	347.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,4BXZT@830|Butyrivibrio	186801|Clostridia	G	Glycosyl hydrolases family 2, sugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_675894_0	1121405.dsmv_1647	4.136e-277	876.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578,ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
MMS1_k127_677112_1	665571.STHERM_c03720	9.437e-71	253.0	2DM20@1|root,31DN4@2|Bacteria,2J5AS@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_677112_0	889378.Spiaf_1726	6.992e-105	353.0	COG1226@1|root,COG1226@2|Bacteria,2J72E@203691|Spirochaetes	203691|Spirochaetes	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
MMS1_k127_677112_2	889378.Spiaf_1725	3.886e-49	180.0	COG0664@1|root,COG0664@2|Bacteria,2J8WG@203691|Spirochaetes	203691|Spirochaetes	T	Cyclic nucleotide binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS1_k127_677112_3	889378.Spiaf_2799	1.497e-36	143.0	COG0170@1|root,COG0170@2|Bacteria,2J6YY@203691|Spirochaetes	203691|Spirochaetes	I	Phosphatidate cytidylyltransferase	cdsA_1	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_681418_0	1500301.JQMF01000024_gene2020	1.078e-178	573.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_685780_1	1196029.ALIM01000014_gene3424	1.811e-99	331.0	COG1175@1|root,COG1175@2|Bacteria,1TQB1@1239|Firmicutes,4HDV6@91061|Bacilli,1ZQ7T@1386|Bacillus	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	msmF3	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_685780_0	748449.Halha_0112	1.278e-102	342.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A3D@186801|Clostridia,3WBSA@53433|Halanaerobiales	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_685780_2	1382358.JHVN01000015_gene594	2.608e-98	328.0	COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,4HA1G@91061|Bacilli,21VDG@150247|Anoxybacillus	91061|Bacilli	G	Alpha-amylase domain	malL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
MMS1_k127_685814_2	1307761.L21SP2_0778	2.102e-17	94.0	COG0812@1|root,COG0812@2|Bacteria,2J5SE@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
MMS1_k127_685814_0	744872.Spica_0668	1.698e-188	599.0	COG0215@1|root,COG0215@2|Bacteria,2J618@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
MMS1_k127_685814_1	1307761.L21SP2_0780	8.635e-50	183.0	COG1595@1|root,COG1595@2|Bacteria,2J64C@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
MMS1_k127_685814_3	1519439.JPJG01000104_gene1836	0.0004732	49.0	COG5662@1|root,COG5662@2|Bacteria,1UQ3R@1239|Firmicutes,257S0@186801|Clostridia,2N7T4@216572|Oscillospiraceae	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
MMS1_k127_688413_0	700598.Niako_0331	2.142e-228	724.0	COG0448@1|root,COG0448@2|Bacteria,4PKFG@976|Bacteroidetes,1IPMM@117747|Sphingobacteriia	976|Bacteroidetes	G	Domain of unknown function (DUF4954)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4954
MMS1_k127_688413_1	573413.Spirs_4300	2.145e-97	327.0	COG1475@1|root,COG1475@2|Bacteria,2J5S6@203691|Spirochaetes	203691|Spirochaetes	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
MMS1_k127_688413_2	573413.Spirs_4301	5.889e-27	111.0	COG1192@1|root,COG1192@2|Bacteria,2J5VP@203691|Spirochaetes	203691|Spirochaetes	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
MMS1_k127_69044_1	1123274.KB899411_gene3206	4.784e-87	298.0	COG1167@1|root,COG1167@2|Bacteria,2J65M@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
MMS1_k127_69044_0	903818.KI912268_gene924	5.14e-228	731.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
MMS1_k127_691213_2	525897.Dbac_2444	1.473e-46	174.0	COG3090@1|root,COG3090@2|Bacteria,1RJ8K@1224|Proteobacteria,42WJ2@68525|delta/epsilon subdivisions,2WS1S@28221|Deltaproteobacteria,2MCGH@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Tripartite ATP-independent periplasmic transporter DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
MMS1_k127_691213_0	1187851.A33M_1665	1.58e-119	393.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
MMS1_k127_691213_1	1408473.JHXO01000012_gene393	1.518e-64	232.0	COG0598@1|root,COG0598@2|Bacteria,4NGM7@976|Bacteroidetes,2FNKU@200643|Bacteroidia	976|Bacteroidetes	P	CorA-like protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMS1_k127_691213_3	1047013.AQSP01000084_gene767	3.238e-43	175.0	COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria	2|Bacteria	C	acetyl-CoA catabolic process	acsC	-	1.3.1.1,1.3.98.1,2.1.1.245	ko:K00197,ko:K00226,ko:K08941,ko:K17723	ko00240,ko00410,ko00680,ko00720,ko00770,ko01100,ko01120,ko01200,map00240,map00410,map00680,map00720,map00770,map01100,map01120,map01200	M00046,M00051,M00357,M00377,M00422,M00598	R00977,R01414,R01867,R09096,R10219,R10243,R11026	RC00004,RC00051,RC00072,RC00113,RC00123,RC02977	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	CdhD,DHO_dh,FeS,Fer4
MMS1_k127_691213_4	573413.Spirs_1408	5.573e-42	171.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
MMS1_k127_703488_0	945550.VISI1226_03430	1.337e-60	228.0	COG1752@1|root,COG1752@2|Bacteria,1Q0D6@1224|Proteobacteria,1TIWT@1236|Gammaproteobacteria,1XZV6@135623|Vibrionales	135623|Vibrionales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
MMS1_k127_703488_1	1382359.JIAL01000001_gene240	3.341e-35	140.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_705267_0	44251.PDUR_14415	2.356e-281	876.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,4HATB@91061|Bacilli,26WMN@186822|Paenibacillaceae	91061|Bacilli	C	Pyruvate formate lyase-like	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
MMS1_k127_705267_2	760011.Spico_0104	2.829e-87	298.0	COG1180@1|root,COG1180@2|Bacteria,2J7S8@203691|Spirochaetes	203691|Spirochaetes	C	glycyl-radical enzyme activating protein family	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
MMS1_k127_705267_1	760011.Spico_0103	3.208e-108	366.0	2AN8N@1|root,31D6Q@2|Bacteria,2J9UT@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_70662_7	1291050.JAGE01000001_gene2238	9.715e-13	79.0	COG3055@1|root,COG4733@1|root,COG3055@2|Bacteria,COG4733@2|Bacteria,1V5WF@1239|Firmicutes,24H47@186801|Clostridia	186801|Clostridia	N	PFAM Kelch	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Kelch_1
MMS1_k127_70662_5	390236.BafPKo_0254	6.373e-89	321.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_70662_2	1307761.L21SP2_0761	1.613e-140	451.0	COG4209@1|root,COG4209@2|Bacteria,2J5XB@203691|Spirochaetes	203691|Spirochaetes	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_70662_3	877418.ATWV01000024_gene2021	3.657e-112	374.0	COG0395@1|root,COG0395@2|Bacteria,2J79R@203691|Spirochaetes	203691|Spirochaetes	P	Binding-protein-dependent transport system inner membrane	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
MMS1_k127_70662_1	1307761.L21SP2_0764	6.912e-243	761.0	COG1653@1|root,COG1653@2|Bacteria,2J5YT@203691|Spirochaetes	203691|Spirochaetes	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
MMS1_k127_70662_4	1307761.L21SP2_0765	3.703e-109	362.0	COG1609@1|root,COG1609@2|Bacteria,2J7A9@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
MMS1_k127_70662_0	926569.ANT_17590	0.0	1065.0	COG3459@1|root,COG3459@2|Bacteria,2G9NQ@200795|Chloroflexi	200795|Chloroflexi	G	Glycosyltransferase 36 associated	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_70662_6	1408473.JHXO01000004_gene264	9.152e-56	199.0	COG0348@1|root,COG0348@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
MMS1_k127_706713_1	1480694.DC28_13680	9.72e-38	150.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	7TMR-DISM_7TM,MCPsignal
MMS1_k127_706713_0	1265505.ATUG01000001_gene3635	2.333e-48	183.0	COG0834@1|root,COG0834@2|Bacteria,1MZGN@1224|Proteobacteria,42R5K@68525|delta/epsilon subdivisions,2WMY7@28221|Deltaproteobacteria,2MKH9@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_706713_2	1283300.ATXB01000001_gene321	1.034e-07	55.0	COG0531@1|root,COG1762@1|root,COG0531@2|Bacteria,COG1762@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1XE0I@135618|Methylococcales	135618|Methylococcales	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
MMS1_k127_707687_0	744872.Spica_0671	2.15e-159	511.0	COG0664@1|root,COG0664@2|Bacteria,2J5G6@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS1_k127_707687_1	1121004.ATVC01000029_gene86	1.303e-14	83.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,2KQV1@206351|Neisseriales	206351|Neisseriales	O	Psort location Cytoplasmic, score	pcm2	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMS1_k127_707687_2	1121451.DESAM_23180	1.876e-12	67.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2M8SI@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
MMS1_k127_714762_3	1121920.AUAU01000024_gene2355	7.446e-36	143.0	COG0074@1|root,COG0074@2|Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	2.3.3.8,6.2.1.5	ko:K01902,ko:K15230,ko:K15233	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00352,R00405,R01322,R02404	RC00004,RC00014,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0306	Citrate_synt,CoA_binding,Ligase_CoA,Succ_CoA_lig
MMS1_k127_714762_1	1517682.HW49_10325	1.2e-99	331.0	COG1266@1|root,COG1266@2|Bacteria,4NVAP@976|Bacteroidetes,2FX87@200643|Bacteroidia	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
MMS1_k127_714762_2	545695.TREAZ_0434	3.491e-54	199.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	ko:K09017,ko:K10913	ko02020,ko02024,ko05111,map02020,map02024,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	TetR_N
MMS1_k127_714762_0	1307761.L21SP2_0797	7.274e-251	786.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,2J5NQ@203691|Spirochaetes	203691|Spirochaetes	C	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
MMS1_k127_714939_5	1410633.JHWR01000009_gene1857	1.6e-10	64.0	COG1254@1|root,COG1254@2|Bacteria,1VEM9@1239|Firmicutes,24QXB@186801|Clostridia,27PTF@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Acylphosphatase	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMS1_k127_714939_2	889378.Spiaf_0669	5.535e-41	153.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
MMS1_k127_714939_1	1123274.KB899410_gene3549	2.607e-42	162.0	COG0745@1|root,COG0745@2|Bacteria,2J7DK@203691|Spirochaetes	203691|Spirochaetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,Response_reg
MMS1_k127_714939_4	573413.Spirs_3751	6.425e-29	126.0	COG2137@1|root,COG2137@2|Bacteria,2J7QC@203691|Spirochaetes	203691|Spirochaetes	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
MMS1_k127_714939_0	1124982.MSI_16680	2.399e-49	178.0	COG0103@1|root,COG0103@2|Bacteria,2J8A0@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS1_k127_714939_3	243275.TDE_0852	1.334e-39	149.0	COG0102@1|root,COG0102@2|Bacteria,2J7C1@203691|Spirochaetes	203691|Spirochaetes	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS1_k127_715415_1	545694.TREPR_1682	1.316e-48	183.0	COG5660@1|root,32WII@2|Bacteria,2J69Q@203691|Spirochaetes	203691|Spirochaetes	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
MMS1_k127_715415_0	744872.Spica_0444	1.914e-128	418.0	COG1640@1|root,COG1640@2|Bacteria,2J5U4@203691|Spirochaetes	203691|Spirochaetes	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
MMS1_k127_715843_2	293826.Amet_3645	4.935e-31	123.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,36DG7@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
MMS1_k127_715843_0	350688.Clos_0127	2.013e-173	553.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,36DHK@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS1_k127_715843_3	877455.Metbo_1957	1.416e-18	93.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,23P3H@183925|Methanobacteria	183925|Methanobacteria	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS1_k127_715843_1	1307761.L21SP2_1572	9.381e-62	225.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	-	-	5.2.1.8	ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
MMS1_k127_72203_1	926556.Echvi_4034	3.014e-60	213.0	COG0363@1|root,COG0363@2|Bacteria	2|Bacteria	G	glucosamine-6-phosphate deaminase activity	-	-	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
MMS1_k127_72203_0	572544.Ilyop_1526	1.559e-129	430.0	COG0025@1|root,COG1762@1|root,COG0025@2|Bacteria,COG1762@2|Bacteria,37CPG@32066|Fusobacteria	32066|Fusobacteria	GPT	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2
MMS1_k127_726289_6	1265505.ATUG01000002_gene1043	3.625e-21	99.0	2C4IE@1|root,30ERP@2|Bacteria,1RG2Q@1224|Proteobacteria,42S4W@68525|delta/epsilon subdivisions,2WND7@28221|Deltaproteobacteria,2MN1X@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_726289_4	1121434.AULY01000009_gene1987	4.618e-46	182.0	COG0500@1|root,COG2226@2|Bacteria,1RB5H@1224|Proteobacteria,43AXN@68525|delta/epsilon subdivisions,2WMND@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_726289_5	324925.Ppha_0345	3.077e-21	107.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
MMS1_k127_726289_2	765420.OSCT_1501	1.158e-77	269.0	COG0614@1|root,COG0614@2|Bacteria,2G6TS@200795|Chloroflexi,3763Q@32061|Chloroflexia	32061|Chloroflexia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS1_k127_726289_1	316274.Haur_1055	5.733e-97	327.0	COG0609@1|root,COG0609@2|Bacteria,2G6E8@200795|Chloroflexi,376D1@32061|Chloroflexia	32061|Chloroflexia	P	FecCD transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
MMS1_k127_726289_3	765420.OSCT_1503	1.428e-75	269.0	COG1120@1|root,COG1120@2|Bacteria,2G6QS@200795|Chloroflexi,376UB@32061|Chloroflexia	32061|Chloroflexia	P	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
MMS1_k127_726289_7	1254432.SCE1572_16810	4.418e-20	95.0	292FR@1|root,2ZPZX@2|Bacteria,1PBNW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_726289_0	889378.Spiaf_2543	1.056e-187	606.0	COG0449@1|root,COG0449@2|Bacteria,2J587@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMS1_k127_726289_8	1480694.DC28_06105	4.256e-11	66.0	2DP5M@1|root,330MG@2|Bacteria,2JB1B@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_727820_1	573413.Spirs_1576	6.978e-37	151.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,2J5P8@203691|Spirochaetes	203691|Spirochaetes	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FliMN_C
MMS1_k127_727820_0	889378.Spiaf_2092	8.038e-176	555.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
MMS1_k127_727820_2	889378.Spiaf_2093	8.933e-27	115.0	COG1580@1|root,COG1580@2|Bacteria,2J7MX@203691|Spirochaetes	203691|Spirochaetes	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
MMS1_k127_728597_1	1307761.L21SP2_2807	1.014e-159	515.0	COG0786@1|root,COG0786@2|Bacteria,2J7YK@203691|Spirochaetes	203691|Spirochaetes	E	glutamate symporter	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
MMS1_k127_728597_2	1304284.L21TH_1182	2.835e-66	242.0	COG0204@1|root,COG0204@2|Bacteria,1V11X@1239|Firmicutes,24AAK@186801|Clostridia,36NG2@31979|Clostridiaceae	186801|Clostridia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
MMS1_k127_728597_0	1415778.JQMM01000001_gene2193	4.098e-164	526.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RNDU@1236|Gammaproteobacteria,1JA8A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_729393_0	1202532.FF52_06520	4.877e-19	100.0	COG4932@1|root,COG4932@2|Bacteria,4NT1H@976|Bacteroidetes,1I663@117743|Flavobacteriia,2NV9S@237|Flavobacterium	976|Bacteroidetes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_731061_1	348780.NP_4646A	0.0005883	50.0	COG1721@1|root,arCOG02742@2157|Archaea,2XTP9@28890|Euryarchaeota,23S9J@183963|Halobacteria	183963|Halobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
MMS1_k127_731061_0	1499967.BAYZ01000089_gene5037	1.407e-123	404.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_732584_1	1396141.BATP01000001_gene5385	5.977e-54	197.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	cmoA	GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281	2.8.1.10	ko:K03149,ko:K15256	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000,ko03016	-	-	-	Methyltransf_25,Methyltransf_31
MMS1_k127_732584_0	313612.L8106_28776	1.529e-88	302.0	COG0500@1|root,COG0500@2|Bacteria,1G34J@1117|Cyanobacteria,1H9EB@1150|Oscillatoriales	1117|Cyanobacteria	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
MMS1_k127_732981_2	441769.ABFU01000044_gene3426	3.218e-20	94.0	COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,4HNKN@91061|Bacilli,1ZHW0@1386|Bacillus	91061|Bacilli	M	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS07900	DAGK_prokar
MMS1_k127_732981_0	1123274.KB899426_gene2815	6.603e-185	593.0	COG1283@1|root,COG1283@2|Bacteria,2J64N@203691|Spirochaetes	203691|Spirochaetes	P	Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
MMS1_k127_732981_1	340099.Teth39_0462	1.458e-117	386.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,42ETK@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
MMS1_k127_738567_1	589865.DaAHT2_0809	2.734e-91	308.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2MK0I@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS1_k127_738567_2	177439.DP1932	3.048e-63	220.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2WQNR@28221|Deltaproteobacteria,2MJWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
MMS1_k127_738567_0	880071.Fleli_1502	8.36e-98	346.0	COG2885@1|root,COG2885@2|Bacteria,4NEND@976|Bacteroidetes,47KG7@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,PD40
MMS1_k127_741227_1	1232437.KL662010_gene1616	5.565e-133	430.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42QQQ@68525|delta/epsilon subdivisions,2WMBP@28221|Deltaproteobacteria,2MIM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_741227_0	177437.HRM2_06340	9.599e-135	436.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2MHMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
MMS1_k127_743016_0	760011.Spico_0100	5.702e-59	214.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_743016_1	760011.Spico_0099	2.587e-46	171.0	COG1172@1|root,COG1172@2|Bacteria	2|Bacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
MMS1_k127_745690_1	1541960.KQ78_01539	1.363e-54	200.0	COG2249@1|root,COG2249@2|Bacteria	2|Bacteria	K	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
MMS1_k127_745690_2	1408473.JHXO01000004_gene2	1.753e-28	121.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Flavodoxin_2
MMS1_k127_750762_7	573413.Spirs_3253	4.818e-41	156.0	COG1963@1|root,COG1963@2|Bacteria,2J7WX@203691|Spirochaetes	203691|Spirochaetes	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
MMS1_k127_750762_3	1307761.L21SP2_3089	3.419e-91	312.0	COG1940@1|root,COG1940@2|Bacteria,2J7X4@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator sugar kinase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,ROK
MMS1_k127_750762_1	573413.Spirs_2893	2.3e-150	490.0	COG0769@1|root,COG0769@2|Bacteria,2J5HR@203691|Spirochaetes	203691|Spirochaetes	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS1_k127_750762_6	665571.STHERM_c17560	1.577e-41	155.0	COG0720@1|root,COG0720@2|Bacteria,2J80J@203691|Spirochaetes	203691|Spirochaetes	H	6-pyruvoyl tetrahydropterin synthase QueD family protein	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMS1_k127_750762_2	889378.Spiaf_1714	7.476e-131	437.0	COG3392@1|root,COG3392@2|Bacteria,2J5IE@203691|Spirochaetes	203691|Spirochaetes	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
MMS1_k127_750762_5	558884.JRGM01000130_gene155	1.035e-74	264.0	COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,1Y3Y8@135624|Aeromonadales	135624|Aeromonadales	J	Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA	rlmG	-	2.1.1.174	ko:K11391	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	MTS
MMS1_k127_750762_0	1168034.FH5T_10680	3.007e-177	569.0	COG2509@1|root,COG2509@2|Bacteria,4NEUQ@976|Bacteroidetes,2FM1G@200643|Bacteroidia	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,FAD_binding_3,GIDA,HI0933_like,Pyr_redox_2
MMS1_k127_750762_4	1117319.PSPO_20801	3.203e-83	286.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,2Q04I@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
MMS1_k127_751892_1	485915.Dret_1205	5.509e-76	257.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS1_k127_751892_0	1249480.B649_06365	2.536e-139	471.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2YNS1@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
MMS1_k127_751892_2	1449355.JQNR01000005_gene3482	1.243e-23	107.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
MMS1_k127_759872_1	1120983.KB894572_gene3172	7.939e-28	117.0	COG1846@1|root,COG1846@2|Bacteria,1NAPN@1224|Proteobacteria,2UHQX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
MMS1_k127_759872_0	269796.Rru_A2789	2.273e-165	536.0	COG0477@1|root,COG0477@2|Bacteria,1PTG6@1224|Proteobacteria,2U4TK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Universal stress protein family	-	-	-	ko:K08221	-	-	-	-	ko00000,ko02000	2.A.1.32	-	-	MFS_1,Usp
MMS1_k127_759872_2	1207076.ALAT01000186_gene2886	4.853e-12	76.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RY2M@1236|Gammaproteobacteria,1Z2IR@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
MMS1_k127_760550_0	158190.SpiGrapes_1871	0.0	1292.0	COG0495@1|root,COG0495@2|Bacteria,2J5BV@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
MMS1_k127_760550_1	1321815.HMPREF9193_01886	1.28e-21	99.0	COG1639@1|root,COG1639@2|Bacteria,2J5NU@203691|Spirochaetes	203691|Spirochaetes	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HDOD
MMS1_k127_761058_1	658086.HMPREF0994_03320	1.45e-59	212.0	COG0388@1|root,COG0388@2|Bacteria,1UEVX@1239|Firmicutes,25JVF@186801|Clostridia,27MBU@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
MMS1_k127_761058_0	484770.UFO1_3871	3.245e-128	419.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4H4X5@909932|Negativicutes	909932|Negativicutes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.130	ko:K08092	ko00040,ko00053,map00040,map00053	-	R02637,R02639	RC00238	ko00000,ko00001,ko01000	-	-	-	Ldh_2
MMS1_k127_766231_1	1121456.ATVA01000014_gene750	7.735e-14	85.0	COG0642@1|root,COG2205@2|Bacteria,1R2IM@1224|Proteobacteria	1224|Proteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4
MMS1_k127_766231_2	98439.AJLL01000081_gene2514	2.354e-13	83.0	COG4251@1|root,COG5002@1|root,COG4251@2|Bacteria,COG5002@2|Bacteria,1FZYQ@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_9,PHY
MMS1_k127_766231_0	1304885.AUEY01000091_gene1629	3.133e-65	230.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria,2MIK0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,Response_reg
MMS1_k127_767442_1	744872.Spica_1001	5.03e-10	71.0	2BFD2@1|root,3296F@2|Bacteria,2JB82@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_767442_0	1307761.L21SP2_0440	1.97e-50	202.0	2C0A1@1|root,33WBM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_767843_1	889378.Spiaf_0452	1.145e-147	480.0	COG2211@1|root,COG2211@2|Bacteria,2J6TU@203691|Spirochaetes	203691|Spirochaetes	G	Na melibiose symporter-like transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
MMS1_k127_767843_4	443254.Marpi_1805	2.158e-59	214.0	COG1647@1|root,COG1647@2|Bacteria,2GCT5@200918|Thermotogae	200918|Thermotogae	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
MMS1_k127_767843_0	573413.Spirs_1903	1.459e-287	904.0	COG1643@1|root,COG1643@2|Bacteria,2J58M@203691|Spirochaetes	203691|Spirochaetes	L	Helicase	hrpA	-	-	-	-	-	-	-	-	-	-	-	DEAD,HA2,Helicase_C,OB_NTP_bind
MMS1_k127_767843_3	945713.IALB_1689	1.207e-75	267.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	JD73_00815	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS1_k127_767843_2	158190.SpiGrapes_1081	2.177e-93	327.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_774159_4	926550.CLDAP_09270	1.051e-61	219.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
MMS1_k127_774159_3	926569.ANT_00880	2.888e-80	282.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
MMS1_k127_774159_5	1296416.JACB01000001_gene3585	7.64e-30	121.0	COG2315@1|root,COG2315@2|Bacteria,4NS6J@976|Bacteroidetes,1I2YP@117743|Flavobacteriia,2YJJ5@290174|Aquimarina	976|Bacteroidetes	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
MMS1_k127_774159_6	5888.CAK85431	6.94e-14	83.0	COG4642@1|root,KOG0231@2759|Eukaryota	2759|Eukaryota	DZ	MORN repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	IQ,MORN
MMS1_k127_774159_1	573413.Spirs_4133	5.855e-108	363.0	COG0745@1|root,COG0745@2|Bacteria,2J6F9@203691|Spirochaetes	203691|Spirochaetes	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS1_k127_774159_0	573413.Spirs_4132	9.706e-186	606.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,2JBGS@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,NUDIX,PAS_4,Response_reg
MMS1_k127_775070_0	545694.TREPR_2780	1.771e-99	344.0	COG0457@1|root,COG1652@1|root,COG0457@2|Bacteria,COG1652@2|Bacteria,2J7YH@203691|Spirochaetes	203691|Spirochaetes	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_775070_1	1353529.M899_2277	2.85e-19	105.0	COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria	1224|Proteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,CarboxypepD_reg,DUF11,FG-GAP
MMS1_k127_775070_2	525904.Tter_2664	0.0001386	56.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Beta_helix,DUF3747,Laminin_G_3,NosD,PQQ_3
MMS1_k127_787348_0	867845.KI911784_gene694	3.922e-201	636.0	COG1129@1|root,COG1129@2|Bacteria,2G649@200795|Chloroflexi,376BP@32061|Chloroflexia	32061|Chloroflexia	P	ABC transporter	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
MMS1_k127_787348_1	326427.Cagg_2576	5.17e-167	531.0	COG4213@1|root,COG4213@2|Bacteria,2G6C4@200795|Chloroflexi,377C5@32061|Chloroflexia	32061|Chloroflexia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
MMS1_k127_787348_2	1123274.KB899414_gene3678	2.635e-121	398.0	COG4213@1|root,COG4213@2|Bacteria,2J67U@203691|Spirochaetes	203691|Spirochaetes	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10543	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
MMS1_k127_787348_3	573413.Spirs_4073	9.782e-47	179.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,2J68A@203691|Spirochaetes	203691|Spirochaetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_787584_1	1449357.JQLK01000001_gene2163	5.491e-10	72.0	COG2199@1|root,COG3706@2|Bacteria,1WI95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
MMS1_k127_787584_0	545695.TREAZ_0886	6.106e-169	544.0	COG0572@1|root,COG0572@2|Bacteria,2J578@203691|Spirochaetes	203691|Spirochaetes	F	PFAM Phosphoribulokinase Uridine kinase family	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
MMS1_k127_788745_1	697281.Mahau_2741	6.322e-116	383.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia,42I6E@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	Cupin_5,GFO_IDH_MocA,GFO_IDH_MocA_C
MMS1_k127_788745_0	1123075.AUDP01000022_gene3620	8.719e-126	407.0	COG3622@1|root,COG3622@2|Bacteria,1TRQV@1239|Firmicutes,24AGD@186801|Clostridia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
MMS1_k127_788745_2	1123274.KB899416_gene2623	7.642e-19	90.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	nagC	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02565,ko:K15545	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR,ROK
MMS1_k127_79157_4	1123274.KB899419_gene1882	3.577e-11	64.0	COG1551@1|root,COG1551@2|Bacteria,2J8VE@203691|Spirochaetes	203691|Spirochaetes	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
MMS1_k127_79157_0	744872.Spica_1119	3.418e-86	299.0	COG2206@1|root,COG2206@2|Bacteria,2J588@203691|Spirochaetes	203691|Spirochaetes	T	HD domain protein	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5
MMS1_k127_79157_2	760011.Spico_0933	4.472e-46	174.0	COG1214@1|root,COG1214@2|Bacteria,2J80U@203691|Spirochaetes	203691|Spirochaetes	O	Universal bacterial protein YeaZ	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
MMS1_k127_79157_3	906968.Trebr_1550	9.893e-42	159.0	COG0802@1|root,COG0802@2|Bacteria,2J8H4@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family UPF0079, ATPase	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
MMS1_k127_79157_5	545695.TREAZ_0334	9.67e-11	65.0	2C5AY@1|root,2ZK7K@2|Bacteria,2J920@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_79157_1	573413.Spirs_2602	3.543e-77	271.0	COG5581@1|root,COG5581@2|Bacteria	2|Bacteria	M	regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
MMS1_k127_791895_1	1123242.JH636436_gene501	3.452e-100	339.0	COG0330@1|root,COG0330@2|Bacteria,2IY12@203682|Planctomycetes	203682|Planctomycetes	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS1_k127_791895_0	1121396.KB893062_gene2778	1.079e-149	482.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2MHPF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
MMS1_k127_793846_5	452637.Oter_1863	1.715e-17	83.0	COG0563@1|root,COG0563@2|Bacteria,46SW4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
MMS1_k127_793846_1	573413.Spirs_3351	4.704e-190	605.0	COG0280@1|root,COG1396@1|root,COG1917@1|root,COG0280@2|Bacteria,COG1396@2|Bacteria,COG1917@2|Bacteria,2J7CE@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,PTA_PTB
MMS1_k127_793846_6	215803.DB30_0318	3.913e-11	70.0	COG1309@1|root,COG1309@2|Bacteria,1NQ0S@1224|Proteobacteria,43AGR@68525|delta/epsilon subdivisions,2WN8X@28221|Deltaproteobacteria,2YX94@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
MMS1_k127_793846_4	545695.TREAZ_1217	2.037e-46	177.0	2BZW8@1|root,32R5W@2|Bacteria,2J6GZ@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_793846_3	1480694.DC28_00660	6.13e-90	301.0	COG1738@1|root,COG1738@2|Bacteria,2J7JS@203691|Spirochaetes	203691|Spirochaetes	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
MMS1_k127_793846_0	762903.Pedsa_3527	2.239e-259	817.0	COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes,1IPB3@117747|Sphingobacteriia	976|Bacteroidetes	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
MMS1_k127_793846_2	744872.Spica_2841	3.045e-98	331.0	COG2172@1|root,COG2172@2|Bacteria,2J5ZY@203691|Spirochaetes	203691|Spirochaetes	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,cNMP_binding
MMS1_k127_80010_1	1118054.CAGW01000061_gene2393	0.000807	51.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
MMS1_k127_80010_0	1123274.KB899409_gene620	1.886e-90	311.0	COG2203@1|root,COG2208@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,COG3850@2|Bacteria,2J5K8@203691|Spirochaetes	203691|Spirochaetes	KT	Stage II sporulation protein E	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GAF_3,SpoIIE
MMS1_k127_801546_0	935837.JAEK01000016_gene1257	7.9e-195	621.0	COG3250@1|root,COG3250@2|Bacteria,1TS9P@1239|Firmicutes,4HB8A@91061|Bacilli,1ZF35@1386|Bacillus	91061|Bacilli	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106,Glyco_hydro_2_N
MMS1_k127_801546_1	1307761.L21SP2_3095	9.846e-113	371.0	COG2723@1|root,COG2723@2|Bacteria,2J6C8@203691|Spirochaetes	203691|Spirochaetes	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
MMS1_k127_808956_0	203119.Cthe_0554	0.0	1092.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3WGRN@541000|Ruminococcaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
MMS1_k127_814469_1	1307761.L21SP2_1821	4.404e-06	50.0	COG2825@1|root,COG2825@2|Bacteria,2J7PA@203691|Spirochaetes	203691|Spirochaetes	M	Cationic outer membrane protein	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
MMS1_k127_814469_0	1123274.KB899421_gene1753	2.184e-278	875.0	COG0249@1|root,COG0249@2|Bacteria,2J5XM@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMS1_k127_81645_0	42256.RradSPS_0358	1.319e-147	490.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
MMS1_k127_818603_2	537013.CLOSTMETH_01912	1.189e-12	70.0	COG1538@1|root,COG3250@1|root,COG1538@2|Bacteria,COG3250@2|Bacteria,1V1D9@1239|Firmicutes,24H7I@186801|Clostridia	2|Bacteria	G	Psort location	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,FIVAR,Glyco_hydro_106,Glyco_hydro_2_N,OEP
MMS1_k127_818603_0	641112.ACOK01000113_gene2004	1.627e-140	461.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3WGBX@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS1_k127_818603_1	938278.CAJO01000010_gene1757	4.458e-33	143.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4,1.3.99.33	ko:K00239,ko:K17363	ko00020,ko00190,ko00340,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00340,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164,R10330	RC00045,RC00669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
MMS1_k127_820839_6	1265505.ATUG01000002_gene1705	1.097e-29	121.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42TKH@68525|delta/epsilon subdivisions,2WQBD@28221|Deltaproteobacteria,2MKEM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
MMS1_k127_820839_5	926561.KB900621_gene2821	7.588e-41	157.0	COG1309@1|root,COG1309@2|Bacteria,1V5H6@1239|Firmicutes,24ITS@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_820839_2	926692.AZYG01000047_gene2611	6.306e-137	449.0	COG0366@1|root,COG0366@2|Bacteria,1TQFJ@1239|Firmicutes,249Y3@186801|Clostridia	186801|Clostridia	G	Alpha amylase, catalytic domain protein	-	-	3.2.1.133,3.2.1.135,3.2.1.54,3.5.4.33	ko:K01208,ko:K11991	ko00500,ko01100,map00500,map01100	-	R02112,R03122,R10223,R11262	RC00477	ko00000,ko00001,ko01000,ko03016	-	GH13	-	Alpha-amylase,Alpha-amylase_C,DUF1653,Malt_amylase_C
MMS1_k127_820839_1	926561.KB900618_gene186	3.399e-186	600.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,Alpha-amylase_N
MMS1_k127_820839_0	1131462.DCF50_p2284	0.0	1091.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2610Q@186807|Peptococcaceae	186801|Clostridia	C	formate C-acetyltransferase glycine radical	pflB	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
MMS1_k127_820839_4	1120998.AUFC01000021_gene939	3.088e-54	201.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMS1_k127_820839_3	1307761.L21SP2_0986	5.291e-76	260.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091,ko:K05967,ko:K07025	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,NT5C
MMS1_k127_82263_1	1082931.KKY_2754	9.2e-103	339.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,3N64Y@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	ABC transporter	glnQ	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
MMS1_k127_82263_0	1082931.KKY_2753	1.078e-114	376.0	COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,2TRCT@28211|Alphaproteobacteria,3N910@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yxeN	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
MMS1_k127_82263_2	314232.SKA53_12753	1.699e-93	311.0	COG0834@1|root,COG0834@2|Bacteria,1R5B4@1224|Proteobacteria,2U2WD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	ET	COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_82314_2	760011.Spico_0867	2.287e-128	416.0	COG0395@1|root,COG0395@2|Bacteria,2J9WE@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_82314_1	760011.Spico_0868	1.053e-143	461.0	COG1175@1|root,COG1175@2|Bacteria,2J7PS@203691|Spirochaetes	203691|Spirochaetes	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS1_k127_82314_0	158189.SpiBuddy_0830	2.75e-176	563.0	COG1653@1|root,COG1653@2|Bacteria,2JA1G@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
MMS1_k127_82314_3	697281.Mahau_0131	1.709e-17	85.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TT49@1239|Firmicutes,24DUZ@186801|Clostridia	186801|Clostridia	K	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_826094_0	1192034.CAP_7988	3.043e-61	233.0	COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	5TM-5TMR_LYT,Cache_3-Cache_2,HAMP,HATPase_c_2,SpoIIE,dCache_1,dCache_2
MMS1_k127_827325_2	1121335.Clst_1264	1.95e-54	204.0	COG1116@1|root,COG1116@2|Bacteria,1V7QX@1239|Firmicutes,24H9Z@186801|Clostridia	186801|Clostridia	P	Abc transporter	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
MMS1_k127_827325_0	933262.AXAM01000024_gene708	5.308e-63	226.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42SE1@68525|delta/epsilon subdivisions,2WPX3@28221|Deltaproteobacteria,2MKIX@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050,ko:K15552	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	BPD_transp_1
MMS1_k127_827325_1	573413.Spirs_3152	5.917e-58	215.0	COG0715@1|root,COG0715@2|Bacteria,2J793@203691|Spirochaetes	203691|Spirochaetes	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
MMS1_k127_827325_3	545694.TREPR_1653	1.919e-39	148.0	COG0760@1|root,COG0760@2|Bacteria,2J7Z8@203691|Spirochaetes	203691|Spirochaetes	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
MMS1_k127_827325_4	4897.EEB08794	2.951e-11	73.0	COG1227@1|root,KOG4129@2759|Eukaryota,38HGT@33154|Opisthokonta,3P0WK@4751|Fungi,3QR58@4890|Ascomycota,3ME8V@451866|Taphrinomycotina	4751|Fungi	C	Exopolyphosphatase	PPX1	GO:0003674,GO:0003824,GO:0004309,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006112,GO:0006793,GO:0006797,GO:0006798,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0070013,GO:0071704,GO:0071944,GO:1901575	3.6.1.11	ko:K01514	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	DHH,DHHA2
MMS1_k127_829462_0	744872.Spica_1380	2.677e-151	486.0	COG3829@1|root,COG3829@2|Bacteria,2J63K@203691|Spirochaetes	203691|Spirochaetes	KT	Transcriptional regulator containing GAF AAA-type ATPase and DNA binding domains	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
MMS1_k127_829462_1	1123274.KB899421_gene1786	4.351e-135	436.0	COG0539@1|root,COG1098@1|root,COG0539@2|Bacteria,COG1098@2|Bacteria,2J5DZ@203691|Spirochaetes	203691|Spirochaetes	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Cytidylate_kin,S1
MMS1_k127_837101_0	1499967.BAYZ01000067_gene6048	3.437e-128	413.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4336,adh_short
MMS1_k127_837101_3	1166018.FAES_4210	5.435e-17	86.0	2EHH2@1|root,33B8Z@2|Bacteria,4NXJU@976|Bacteroidetes,47TWB@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
MMS1_k127_837101_2	653733.Selin_2005	4.224e-29	124.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
MMS1_k127_837101_1	1042376.AFPK01000043_gene996	7.951e-73	252.0	COG1514@1|root,COG1514@2|Bacteria,4NPIG@976|Bacteroidetes,1I29U@117743|Flavobacteriia	976|Bacteroidetes	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2,AKAP7_NLS
MMS1_k127_837913_2	938709.AUSH02000011_gene1191	8.817e-41	160.0	COG3279@1|root,COG3279@2|Bacteria,4NFWA@976|Bacteroidetes	976|Bacteroidetes	T	Response regulator of the LytR AlgR family	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
MMS1_k127_837913_0	1499967.BAYZ01000139_gene129	2.179e-180	575.0	COG2723@1|root,COG2723@2|Bacteria,2NPRZ@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 1	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
MMS1_k127_837913_1	1536773.R70331_07445	4.733e-43	168.0	COG2207@1|root,COG2207@2|Bacteria,1V4GS@1239|Firmicutes,4I6V3@91061|Bacilli,26V3X@186822|Paenibacillaceae	91061|Bacilli	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
MMS1_k127_837913_4	768710.DesyoDRAFT_1321	3.707e-14	78.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,264FS@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,HATPase_c,His_kinase
MMS1_k127_837913_3	335541.Swol_1622	4.502e-31	132.0	COG2199@1|root,COG3706@2|Bacteria,1TR5R@1239|Firmicutes,24E9M@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,GGDEF
MMS1_k127_838039_2	933262.AXAM01000001_gene329	1.786e-70	251.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42QP2@68525|delta/epsilon subdivisions,2WN62@28221|Deltaproteobacteria,2MJK0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
MMS1_k127_838039_1	273068.TTE0091	2.445e-77	266.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,42FGP@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
MMS1_k127_838039_3	794903.OPIT5_18330	1.736e-43	169.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,46U3Q@74201|Verrucomicrobia,3K83C@414999|Opitutae	414999|Opitutae	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
MMS1_k127_838039_0	1307761.L21SP2_2350	2.846e-184	586.0	COG1486@1|root,COG1486@2|Bacteria,2J688@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Glycoside hydrolase, family 4	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
MMS1_k127_840835_11	1307761.L21SP2_2764	1.698e-20	91.0	COG2217@1|root,COG2217@2|Bacteria,2J60R@203691|Spirochaetes	203691|Spirochaetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	zntA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS1_k127_840835_9	1307761.L21SP2_2763	7.04e-34	132.0	COG1937@1|root,COG1937@2|Bacteria,2J86Q@203691|Spirochaetes	203691|Spirochaetes	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
MMS1_k127_840835_3	572544.Ilyop_0476	7.807e-134	436.0	COG1929@1|root,COG1929@2|Bacteria,379HN@32066|Fusobacteria	32066|Fusobacteria	G	Belongs to the glycerate kinase type-1 family	-	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
MMS1_k127_840835_2	1166948.JPZL01000002_gene1755	4.513e-196	620.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RP0M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate	garD	GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575	4.2.1.42	ko:K01708	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	iECED1_1282.ECED1_3790,iECP_1309.ECP_3218,iLF82_1304.LF82_0803,iNRG857_1313.NRG857_15535	GD_AH_C,SAF
MMS1_k127_840835_1	572480.Arnit_1031	1.806e-200	635.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2YN7A@29547|Epsilonproteobacteria	68525|delta/epsilon subdivisions	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
MMS1_k127_840835_10	1178482.BJB45_03815	9.209e-23	103.0	2EBTI@1|root,335T4@2|Bacteria,1NDHT@1224|Proteobacteria	1224|Proteobacteria	S	Tripartite Tricarboxylate transporter (TTT) small transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	TctB
MMS1_k127_840835_7	1121943.KB899997_gene1867	4.424e-64	223.0	COG3181@1|root,COG3181@2|Bacteria,1R5C8@1224|Proteobacteria,1S1K9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_840835_8	1121939.L861_12610	1.474e-62	220.0	COG3181@1|root,COG3181@2|Bacteria,1R5C8@1224|Proteobacteria,1S1K9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_840835_0	1117379.BABA_00755	1.509e-234	730.0	COG4948@1|root,COG4948@2|Bacteria,1TUWS@1239|Firmicutes,4HCCY@91061|Bacilli,1ZE3M@1386|Bacillus	91061|Bacilli	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	gudD	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS1_k127_840835_4	1123288.SOV_5c03620	9.063e-131	422.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,4H33H@909932|Negativicutes	909932|Negativicutes	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding protein	garR	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
MMS1_k127_840835_5	1410668.JNKC01000001_gene1766	1.762e-101	340.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,24CFW@186801|Clostridia,36VPS@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS1_k127_840835_6	756883.Halar_0319	6.995e-65	234.0	COG0111@1|root,arCOG01754@2157|Archaea	2157|Archaea	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA3	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS1_k127_843948_0	1163671.JAGI01000003_gene392	1.925e-79	273.0	COG1175@1|root,COG1175@2|Bacteria,1VSHG@1239|Firmicutes,24GUI@186801|Clostridia,36Q9T@31979|Clostridiaceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS1_k127_843948_1	1284352.AOIG01000011_gene1396	1.069e-68	248.0	COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,4HCBS@91061|Bacilli,26VM7@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	msmE	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_843948_3	658086.HMPREF0994_03428	2.461e-31	130.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V27N@1239|Firmicutes,24EUU@186801|Clostridia,27NS0@186928|unclassified Lachnospiraceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
MMS1_k127_843948_4	1499968.TCA2_1809	4.975e-15	76.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,4HI3Z@91061|Bacilli,26T2X@186822|Paenibacillaceae	91061|Bacilli	T	COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
MMS1_k127_843948_2	1450694.BTS2_2372	4.439e-51	197.0	COG2972@1|root,COG2972@2|Bacteria,1UY73@1239|Firmicutes,4HD3Y@91061|Bacilli,1ZPX8@1386|Bacillus	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
MMS1_k127_844957_1	316055.RPE_4865	8.735e-139	459.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,3JS80@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Alpha-amylase domain	MA20_23410	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
MMS1_k127_844957_0	1307761.L21SP2_0748	5.4e-177	567.0	COG2939@1|root,COG2939@2|Bacteria	2|Bacteria	E	PFAM Peptidase S10, serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
MMS1_k127_844957_3	158189.SpiBuddy_2762	5.684e-40	160.0	COG2197@1|root,COG2197@2|Bacteria,2J9AC@203691|Spirochaetes	203691|Spirochaetes	KT	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
MMS1_k127_844957_2	879212.DespoDRAFT_00137	3.404e-44	167.0	COG0534@1|root,COG0534@2|Bacteria,1NS6X@1224|Proteobacteria,42PC5@68525|delta/epsilon subdivisions,2X5H4@28221|Deltaproteobacteria,2MKJE@213118|Desulfobacterales	28221|Deltaproteobacteria	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS1_k127_850665_0	394503.Ccel_2511	8.288e-83	291.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,36JG4@31979|Clostridiaceae	186801|Clostridia	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
MMS1_k127_850665_1	1220534.B655_1658	2.613e-73	260.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,23NV3@183925|Methanobacteria	183925|Methanobacteria	E	PFAM Aminotransferase, class I	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS1_k127_850665_2	926566.Terro_3292	2.636e-48	189.0	COG2171@1|root,COG2171@2|Bacteria,3Y2Z3@57723|Acidobacteria,2JIDV@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the transferase hexapeptide repeat family	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_N_2
MMS1_k127_850665_3	546262.NEICINOT_04656	2.412e-09	69.0	COG4390@1|root,COG4390@2|Bacteria,1N0HI@1224|Proteobacteria,2WGAN@28216|Betaproteobacteria,2KRPY@206351|Neisseriales	206351|Neisseriales	L	Uncharacterized protein conserved in bacteria (DUF2322)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2322
MMS1_k127_851406_5	401526.TcarDRAFT_0968	2.213e-49	184.0	COG0247@1|root,COG0247@2|Bacteria,1TQJM@1239|Firmicutes,4H2DH@909932|Negativicutes	909932|Negativicutes	C	Cysteine-rich domain	glpC	-	1.1.5.3	ko:K00113	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
MMS1_k127_851406_2	926569.ANT_03750	5.209e-62	226.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
MMS1_k127_851406_0	926569.ANT_03740	4.199e-71	248.0	COG1116@1|root,COG1116@2|Bacteria,2G8SU@200795|Chloroflexi	200795|Chloroflexi	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
MMS1_k127_851406_1	926569.ANT_03730	4.528e-63	226.0	COG0600@1|root,COG0600@2|Bacteria,2G72A@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
MMS1_k127_851406_3	1045009.AFXQ01000008_gene1834	1.852e-61	218.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,1W7IB@1268|Micrococcaceae	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS1_k127_851406_4	926550.CLDAP_30590	9.443e-61	215.0	COG1575@1|root,COG1575@2|Bacteria,2G5ZC@200795|Chloroflexi	200795|Chloroflexi	H	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS1_k127_852058_5	404589.Anae109_0736	3.153e-05	47.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,42V8V@68525|delta/epsilon subdivisions,2WRKG@28221|Deltaproteobacteria,2Z1JK@29|Myxococcales	28221|Deltaproteobacteria	C	acylphosphatase activity	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMS1_k127_852058_0	889378.Spiaf_0670	4.774e-232	723.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMS1_k127_852058_2	665571.STHERM_c02730	1.377e-167	544.0	COG0442@1|root,COG0442@2|Bacteria,2J5HF@203691|Spirochaetes	203691|Spirochaetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
MMS1_k127_852058_4	1307761.L21SP2_0181	1.856e-43	170.0	COG0454@1|root,COG0456@2|Bacteria,2J74W@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,UPF0158
MMS1_k127_852058_3	889378.Spiaf_0673	9.691e-70	246.0	COG0204@1|root,COG0204@2|Bacteria,2J6GX@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
MMS1_k127_852058_1	573413.Spirs_3744	8.844e-189	605.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS1_k127_852215_0	1499967.BAYZ01000090_gene4959	1.36e-313	970.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2NNT2@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K00167,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
MMS1_k127_852215_1	158189.SpiBuddy_2223	8.247e-149	482.0	COG0613@1|root,COG0613@2|Bacteria,2J6D0@203691|Spirochaetes	203691|Spirochaetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_852215_2	760011.Spico_1649	2.903e-20	98.0	COG1028@1|root,COG1028@2|Bacteria,2J6IK@203691|Spirochaetes	203691|Spirochaetes	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
MMS1_k127_852591_0	744872.Spica_0983	6.478e-108	360.0	COG1181@1|root,COG1181@2|Bacteria,2J611@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
MMS1_k127_852591_4	545694.TREPR_3415	4.179e-37	154.0	2EBXX@1|root,335X9@2|Bacteria,2J6WG@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_852591_1	357808.RoseRS_3736	3.652e-70	252.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,2GBIC@200795|Chloroflexi,3780I@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
MMS1_k127_852591_3	1380390.JIAT01000009_gene1863	3.668e-57	207.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CU2Q@84995|Rubrobacteria	84995|Rubrobacteria	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_852591_5	1480694.DC28_13950	1.167e-21	96.0	COG5566@1|root,COG5566@2|Bacteria,2J8WP@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Mor transcription activator	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_852591_2	509191.AEDB02000073_gene2005	1.908e-58	207.0	COG1609@1|root,COG4191@1|root,COG1609@2|Bacteria,COG4191@2|Bacteria,1UCKT@1239|Firmicutes,24GBZ@186801|Clostridia,3WNR7@541000|Ruminococcaceae	186801|Clostridia	KT	Periplasmic binding protein domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Peripla_BP_3
MMS1_k127_853211_1	906968.Trebr_1691	6.582e-05	50.0	COG0265@1|root,COG0265@2|Bacteria,2J5GT@203691|Spirochaetes	203691|Spirochaetes	O	periplasmic serine protease, Do	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
MMS1_k127_853211_0	1307761.L21SP2_1861	2.447e-87	293.0	COG0024@1|root,COG0024@2|Bacteria,2J5Z7@203691|Spirochaetes	203691|Spirochaetes	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS1_k127_853952_2	349521.HCH_01936	1.973e-38	154.0	COG0834@1|root,COG0834@2|Bacteria,1RDZV@1224|Proteobacteria,1S9M9@1236|Gammaproteobacteria,1XPHY@135619|Oceanospirillales	135619|Oceanospirillales	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_853952_0	1408422.JHYF01000013_gene500	1.356e-116	383.0	COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia,36F1A@31979|Clostridiaceae	186801|Clostridia	S	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_853952_1	1307761.L21SP2_0116	2.564e-69	248.0	COG4587@1|root,COG4587@2|Bacteria,2J8ZR@203691|Spirochaetes	203691|Spirochaetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
MMS1_k127_857857_2	439235.Dalk_0162	7.057e-66	234.0	COG3576@1|root,COG3576@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
MMS1_k127_857857_1	439235.Dalk_0163	5.683e-103	344.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,42R2E@68525|delta/epsilon subdivisions,2WMYN@28221|Deltaproteobacteria,2MJPF@213118|Desulfobacterales	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
MMS1_k127_857857_0	439235.Dalk_0164	0.0	1186.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,42M5J@68525|delta/epsilon subdivisions,2WJAK@28221|Deltaproteobacteria	1224|Proteobacteria	C	formate C-acetyltransferase glycine radical	-	-	-	-	-	-	-	-	-	-	-	-	PFL-like
MMS1_k127_857857_4	318424.EU78_19780	1.719e-15	85.0	COG2186@1|root,COG2186@2|Bacteria,2I90D@201174|Actinobacteria,236Z8@1762|Mycobacteriaceae	201174|Actinobacteria	K	GntR family	mce2R	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043207,GO:0043565,GO:0044403,GO:0044419,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS1_k127_857857_3	1297570.MESS4_60145	9.44e-26	111.0	COG0010@1|root,COG3457@1|root,COG0010@2|Bacteria,COG3457@2|Bacteria,1MW9K@1224|Proteobacteria,2U36W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the arginase family	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,Arginase
MMS1_k127_859803_0	290512.Paes_1630	5.924e-250	778.0	COG2710@1|root,COG2710@2|Bacteria,1FDEX@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM nitrogenase molybdenum-iron protein alpha chain	-	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
MMS1_k127_859803_1	573413.Spirs_3004	7.901e-194	611.0	COG2710@1|root,COG2710@2|Bacteria,2J64D@203691|Spirochaetes	203691|Spirochaetes	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	nifK	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
MMS1_k127_861241_1	1347392.CCEZ01000049_gene1402	1.217e-118	392.0	COG3275@1|root,COG3275@2|Bacteria,1VTXF@1239|Firmicutes,25E5Z@186801|Clostridia,36E2G@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K02478,ko:K07704	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,GAF_3,HATPase_c,His_kinase
MMS1_k127_861241_2	1347392.CCEZ01000049_gene1401	4.121e-53	196.0	COG3279@1|root,COG3279@2|Bacteria,1V14X@1239|Firmicutes,24BG9@186801|Clostridia,36E97@31979|Clostridiaceae	186801|Clostridia	KT	response regulator	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
MMS1_k127_861241_0	1304284.L21TH_2476	2.209e-215	677.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,36EVZ@31979|Clostridiaceae	186801|Clostridia	T	carbon starvation protein CstA	cstA	-	-	-	-	-	-	-	-	-	-	-	CstA,CstA_5TM
MMS1_k127_861241_3	1232683.ADIMK_1380	3.015e-34	138.0	COG2204@1|root,COG2204@2|Bacteria,1PAPS@1224|Proteobacteria,1RSD2@1236|Gammaproteobacteria,469MP@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_863744_0	305900.GV64_19445	3.171e-207	657.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
MMS1_k127_863744_4	1169144.KB911001_gene2723	8.969e-14	81.0	COG4200@1|root,COG4200@2|Bacteria,1UJCS@1239|Firmicutes,4IT5G@91061|Bacilli,1ZRAI@1386|Bacillus	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	ko:K19310	ko02010,map02010	M00747	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.131.1	-	-	ABC2_membrane_4
MMS1_k127_863744_1	1035308.AQYY01000002_gene610	1.217e-74	261.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,253U3@186801|Clostridia,26271@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990,ko:K19309	ko02010,map02010	M00254,M00747	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.131.1	-	-	ABC_tran
MMS1_k127_863744_2	1209989.TepiRe1_0315	8.33e-33	134.0	COG1309@1|root,COG1309@2|Bacteria,1VC66@1239|Firmicutes,25I8N@186801|Clostridia,42IV6@68295|Thermoanaerobacterales	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_863744_3	1123405.AUMM01000003_gene528	9.803e-31	136.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,26NHT@186821|Sporolactobacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like
MMS1_k127_863744_5	880073.Calab_0473	7.358e-13	74.0	COG0745@1|root,COG0745@2|Bacteria,2NQPY@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_863819_7	386456.JQKN01000002_gene2630	4.352e-52	192.0	COG1237@1|root,arCOG00503@2157|Archaea,2XVHM@28890|Euryarchaeota	28890|Euryarchaeota	S	beta-lactamase	-	GO:0003674,GO:0003824,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0042558,GO:0044237,GO:0044249,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901564	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Lactamase_B_2
MMS1_k127_863819_3	635013.TherJR_1901	3.343e-69	246.0	COG0667@1|root,COG2221@1|root,COG0667@2|Bacteria,COG2221@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia,2600R@186807|Peptococcaceae	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
MMS1_k127_863819_5	1122915.AUGY01000079_gene3322	3.973e-56	205.0	COG2227@1|root,COG2227@2|Bacteria,1V9DM@1239|Firmicutes,4IQ8C@91061|Bacilli,2768C@186822|Paenibacillaceae	91061|Bacilli	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_863819_8	744872.Spica_2407	2.237e-45	171.0	COG0454@1|root,COG0456@2|Bacteria,2J8BV@203691|Spirochaetes	203691|Spirochaetes	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_863819_11	1121935.AQXX01000098_gene1640	4.13e-27	121.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_863819_6	525897.Dbac_3075	9.231e-53	196.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,42XB2@68525|delta/epsilon subdivisions,2WT59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_863819_10	931626.Awo_c20780	4.454e-30	126.0	COG1309@1|root,COG1309@2|Bacteria,1VHP8@1239|Firmicutes,25BY0@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_863819_0	340099.Teth39_0204	2.475e-132	433.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,42ENG@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
MMS1_k127_863819_12	913325.N799_11240	1.572e-15	85.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S49E@1236|Gammaproteobacteria,1X380@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMS1_k127_863819_4	1278307.KB906971_gene1501	1.163e-64	229.0	COG0834@1|root,COG0834@2|Bacteria,1RHK1@1224|Proteobacteria,1SZDW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
MMS1_k127_863819_2	1121324.CLIT_2c00700	2.502e-69	241.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding	moeB	-	-	-	-	-	-	-	-	-	-	-	ThiF
MMS1_k127_863819_1	332101.JIBU02000039_gene1687	1.267e-87	295.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,36F1K@31979|Clostridiaceae	186801|Clostridia	S	(AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
MMS1_k127_863819_9	1121459.AQXE01000014_gene375	6.336e-37	143.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria,2M9BC@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
MMS1_k127_865190_1	595460.RRSWK_05522	8.941e-39	159.0	COG1721@1|root,COG1721@2|Bacteria,2IY4D@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_865190_0	292459.STH463	3.27e-108	359.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_872106_5	889378.Spiaf_0293	9.283e-21	93.0	COG4120@1|root,COG4120@2|Bacteria,2J6KD@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
MMS1_k127_872106_4	1307761.L21SP2_2673	8.252e-30	120.0	COG4120@1|root,COG4120@2|Bacteria,2J6KD@203691|Spirochaetes	203691|Spirochaetes	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
MMS1_k127_872106_0	243231.GSU0212	1.553e-111	368.0	COG1101@1|root,COG1101@2|Bacteria,1MVDM@1224|Proteobacteria,42N3W@68525|delta/epsilon subdivisions,2WJD3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ABC transporter related	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
MMS1_k127_872106_2	1056512.D515_01477	1.535e-47	183.0	COG0406@1|root,COG0406@2|Bacteria,1N1NR@1224|Proteobacteria,1SBM5@1236|Gammaproteobacteria,1Y0P4@135623|Vibrionales	135623|Vibrionales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
MMS1_k127_872106_1	1499967.BAYZ01000041_gene2335	3.539e-102	347.0	COG0371@1|root,COG0371@2|Bacteria,2NRET@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
MMS1_k127_872106_3	709991.Odosp_2805	2.19e-46	171.0	COG0174@1|root,COG0174@2|Bacteria,4NHET@976|Bacteroidetes,2FNAX@200643|Bacteroidia,22W4G@171551|Porphyromonadaceae	976|Bacteroidetes	E	Psort location Cytoplasmic, score	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMS1_k127_879844_0	573413.Spirs_1634	1.404e-173	552.0	COG4214@1|root,COG4214@2|Bacteria,2J5AE@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
MMS1_k127_879844_1	1123274.KB899413_gene782	2.648e-60	212.0	COG1129@1|root,COG1129@2|Bacteria,2J5EN@203691|Spirochaetes	203691|Spirochaetes	P	Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K02056,ko:K10545,ko:K10548	ko02010,map02010	M00215,M00216,M00221	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2,3.A.1.2.4,3.A.1.2.5	-	-	ABC_tran
MMS1_k127_880490_0	153721.MYP_397	6.226e-132	449.0	COG3321@1|root,COG3321@2|Bacteria,4PKD5@976|Bacteroidetes,47XYI@768503|Cytophagia	976|Bacteroidetes	Q	PKS_KR	-	-	-	-	-	-	-	-	-	-	-	-	KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
MMS1_k127_880930_2	215803.DB30_2677	7.421e-54	206.0	COG2114@1|root,COG2114@2|Bacteria,1Q3RQ@1224|Proteobacteria,439G1@68525|delta/epsilon subdivisions,2X4RV@28221|Deltaproteobacteria,2YZGG@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
MMS1_k127_880930_1	1480694.DC28_12230	7.466e-69	250.0	COG4585@1|root,COG4585@2|Bacteria,2J7E5@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
MMS1_k127_880930_0	1480694.DC28_12225	1.79e-94	314.0	COG2197@1|root,COG2197@2|Bacteria,2J7CS@203691|Spirochaetes	203691|Spirochaetes	K	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_883815_1	744872.Spica_2615	2.369e-80	285.0	COG0366@1|root,COG0366@2|Bacteria,2J649@203691|Spirochaetes	203691|Spirochaetes	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
MMS1_k127_883815_0	573413.Spirs_0265	2.136e-213	680.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2J65C@203691|Spirochaetes	203691|Spirochaetes	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
MMS1_k127_883815_3	869209.Tresu_0098	4.157e-05	53.0	29Y8R@1|root,30K2G@2|Bacteria,2J85K@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_883815_2	1307761.L21SP2_0034	1.094e-18	94.0	COG1301@1|root,COG1301@2|Bacteria,2J6P3@203691|Spirochaetes	203691|Spirochaetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
MMS1_k127_890847_1	555779.Dthio_PD1190	2.218e-31	133.0	COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,42RVU@68525|delta/epsilon subdivisions,2WNVU@28221|Deltaproteobacteria,2MA7N@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K14347	-	-	-	-	ko00000,ko02000,ko04147	2.A.93.1	-	-	SBF_like
MMS1_k127_890847_3	38727.Pavir.Aa03530.1.p	0.0002458	47.0	COG1245@1|root,KOG0063@2759|Eukaryota,37NH5@33090|Viridiplantae,3GC1Z@35493|Streptophyta,3KXHN@4447|Liliopsida,3IMRT@38820|Poales	35493|Streptophyta	A	4Fe-4S binding domain	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
MMS1_k127_890847_0	585394.RHOM_02165	4.728e-116	387.0	COG5164@1|root,COG5434@1|root,COG5164@2|Bacteria,COG5434@2|Bacteria,1TSA5@1239|Firmicutes,24B0W@186801|Clostridia	186801|Clostridia	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_890847_2	1227360.C176_02423	8.861e-22	101.0	COG0583@1|root,COG0583@2|Bacteria,1TST3@1239|Firmicutes,4HDBC@91061|Bacilli,26FMZ@186818|Planococcaceae	91061|Bacilli	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
MMS1_k127_893798_3	926549.KI421517_gene2880	4.163e-49	179.0	COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes,47P8B@768503|Cytophagia	976|Bacteroidetes	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
MMS1_k127_893798_4	697281.Mahau_0420	1.137e-39	165.0	COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia,42EZ7@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
MMS1_k127_893798_0	456442.Mboo_0759	1.665e-93	319.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,2N915@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMS1_k127_893798_1	935845.JADQ01000007_gene1642	5.153e-62	218.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,4HNJW@91061|Bacilli,2768A@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS1_k127_893798_2	1121920.AUAU01000017_gene1213	9.007e-52	187.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4,LMWPc
MMS1_k127_896136_3	316067.Geob_1146	9.866e-15	75.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,42W91@68525|delta/epsilon subdivisions,2WRAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
MMS1_k127_896136_1	1267534.KB906755_gene4156	1.227e-128	419.0	COG0673@1|root,COG0673@2|Bacteria,3Y6Z2@57723|Acidobacteria,2JMN3@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
MMS1_k127_896136_2	1185876.BN8_02490	1.053e-87	296.0	COG0274@1|root,COG0274@2|Bacteria,4NGE3@976|Bacteroidetes,47NNP@768503|Cytophagia	976|Bacteroidetes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
MMS1_k127_896136_0	1094980.Mpsy_0445	2.195e-136	449.0	COG2195@1|root,arCOG05229@2157|Archaea,2Y380@28890|Euryarchaeota,2NAGH@224756|Methanomicrobia	224756|Methanomicrobia	E	Peptidase family M20/M25/M40	-	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M20
MMS1_k127_90132_1	641107.CDLVIII_2266	4.696e-42	161.0	COG1309@1|root,COG1309@2|Bacteria,1V4J0@1239|Firmicutes,24XDH@186801|Clostridia,36PUZ@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_90132_0	1382304.JNIL01000001_gene648	8.809e-126	414.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,2786J@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF_1	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS1_k127_901377_0	1125701.HMPREF1221_02440	8.327e-127	415.0	COG2890@1|root,COG2890@2|Bacteria,2J6RB@203691|Spirochaetes	203691|Spirochaetes	J	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
MMS1_k127_901377_2	1125725.HMPREF1325_0903	2.264e-36	147.0	2DS2V@1|root,32US7@2|Bacteria,2J85C@203691|Spirochaetes	203691|Spirochaetes	S	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_2
MMS1_k127_901377_1	1125701.HMPREF1221_02442	1.051e-38	154.0	COG0204@1|root,COG0204@2|Bacteria,2J5GX@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
MMS1_k127_902431_1	1123274.KB899421_gene1813	1.723e-23	111.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
MMS1_k127_902431_0	545694.TREPR_2441	5.705e-52	191.0	COG2227@1|root,COG2227@2|Bacteria,2J59U@203691|Spirochaetes	203691|Spirochaetes	H	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_905799_0	1123274.KB899409_gene486	2.317e-204	676.0	COG2373@1|root,COG2373@2|Bacteria,2J5M0@203691|Spirochaetes	203691|Spirochaetes	S	Alpha-2-macroglobulin family	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Big_5,MG1
MMS1_k127_905799_3	889378.Spiaf_2834	9.71e-78	270.0	COG0791@1|root,COG0791@2|Bacteria,2J73P@203691|Spirochaetes	203691|Spirochaetes	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
MMS1_k127_905799_2	1125700.HMPREF9195_01673	2.271e-96	326.0	COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes	203691|Spirochaetes	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
MMS1_k127_905799_4	203124.Tery_1252	2.131e-77	269.0	COG0530@1|root,COG0530@2|Bacteria,1G1Y9@1117|Cyanobacteria,1H7D3@1150|Oscillatoriales	1117|Cyanobacteria	P	K -dependent Na Ca exchanger	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMS1_k127_905799_5	237368.SCABRO_03003	1.556e-63	226.0	COG2935@1|root,COG2935@2|Bacteria,2IZT8@203682|Planctomycetes	203682|Planctomycetes	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
MMS1_k127_905799_1	158189.SpiBuddy_2723	1.499e-111	386.0	COG0826@1|root,COG0826@2|Bacteria,2J667@203691|Spirochaetes	203691|Spirochaetes	O	Peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
MMS1_k127_905799_7	744872.Spica_2854	1.335e-11	74.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,2J681@203691|Spirochaetes	203691|Spirochaetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8,Transglut_core
MMS1_k127_910144_1	1408473.JHXO01000011_gene3075	5.427e-47	175.0	COG0566@1|root,COG0566@2|Bacteria,4NFH3@976|Bacteroidetes,2FSSX@200643|Bacteroidia	976|Bacteroidetes	J	Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
MMS1_k127_910144_0	665571.STHERM_c01010	2.954e-81	279.0	COG1216@1|root,COG1216@2|Bacteria,2J8ZQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_910144_2	521011.Mpal_0512	2.136e-05	56.0	COG1413@1|root,arCOG02966@2157|Archaea	2157|Archaea	C	PBS lyase HEAT domain protein repeat-containing protein	prp	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
MMS1_k127_910961_1	661478.OP10G_1967	3.125e-15	82.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	chbR	-	-	ko:K03490	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,Cupin_2,HTH_18
MMS1_k127_910961_0	1123274.KB899410_gene3492	1.979e-220	713.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes	203691|Spirochaetes	T	Adenylate guanylate cyclase catalytic domain protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
MMS1_k127_911591_0	880073.Calab_0150	5.153e-36	149.0	COG1597@1|root,COG1597@2|Bacteria,2NQYH@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
MMS1_k127_911591_1	269799.Gmet_0363	1.093e-25	115.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,43SI8@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
MMS1_k127_911870_6	1297742.A176_03617	7.001e-08	59.0	COG2114@1|root,COG2114@2|Bacteria,1Q3RQ@1224|Proteobacteria,439G1@68525|delta/epsilon subdivisions,2X4RV@28221|Deltaproteobacteria,2YZGG@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
MMS1_k127_911870_4	443144.GM21_1846	8.252e-44	165.0	COG0778@1|root,COG0778@2|Bacteria,1REJI@1224|Proteobacteria,42RKQ@68525|delta/epsilon subdivisions,2WNPF@28221|Deltaproteobacteria,43UVH@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_911870_1	96561.Dole_0644	8.66e-110	366.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42MFI@68525|delta/epsilon subdivisions,2WKXD@28221|Deltaproteobacteria,2MM6V@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_911870_5	1511.CLOST_0711	3.005e-41	158.0	COG1633@1|root,COG1633@2|Bacteria,1VAXV@1239|Firmicutes,24KX7@186801|Clostridia	186801|Clostridia	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
MMS1_k127_911870_2	478749.BRYFOR_06744	1.366e-82	277.0	COG0778@1|root,COG0778@2|Bacteria,1V4K6@1239|Firmicutes,24B09@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	nfrA2	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_911870_0	589865.DaAHT2_1817	4.22e-151	489.0	COG1373@1|root,COG1373@2|Bacteria,1MWDX@1224|Proteobacteria,42YS5@68525|delta/epsilon subdivisions,2WTZG@28221|Deltaproteobacteria,2MMRX@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
MMS1_k127_911870_3	1278078.G419_20545	6.504e-48	182.0	COG3250@1|root,COG3250@2|Bacteria,2I952@201174|Actinobacteria,4FUJ0@85025|Nocardiaceae	201174|Actinobacteria	G	Protein of unknown function (DUF2804)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2804
MMS1_k127_91196_1	717605.Theco_0458	1.877e-137	447.0	COG1653@1|root,COG1653@2|Bacteria,1U2P7@1239|Firmicutes,4HCY4@91061|Bacilli,26T3M@186822|Paenibacillaceae	91061|Bacilli	G	Sugar ABC transporter substrate-binding protein	msmE3	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_91196_2	985665.HPL003_11055	9.893e-103	342.0	COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,4HCRQ@91061|Bacilli,26U8Z@186822|Paenibacillaceae	91061|Bacilli	P	Permease	msmF1	-	-	ko:K10118	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_91196_4	717605.Theco_0460	3.475e-92	313.0	COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,4HDJN@91061|Bacilli,26SH8@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter permease	-	-	-	ko:K10119	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	BPD_transp_1
MMS1_k127_91196_0	717605.Theco_0462	2.32e-166	534.0	COG5520@1|root,COG5520@2|Bacteria,1TS99@1239|Firmicutes,4HEH6@91061|Bacilli,26STJ@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the glycosyl hydrolase 30 family	srfJ1	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
MMS1_k127_91196_3	1122917.KB899667_gene3572	1.076e-92	308.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,4HAFW@91061|Bacilli,26QC2@186822|Paenibacillaceae	91061|Bacilli	G	beta-galactosidase	lacZ3	-	3.2.1.23	ko:K01190,ko:K12308	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
MMS1_k127_912871_0	158189.SpiBuddy_0713	2.268e-153	492.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
MMS1_k127_912871_2	1391647.AVSV01000011_gene1168	1.871e-26	115.0	COG1309@1|root,COG1309@2|Bacteria,1V9ST@1239|Firmicutes,24RIW@186801|Clostridia,36MZ3@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_912871_1	1043493.BBLU01000007_gene64	2.087e-63	230.0	2ERDU@1|root,33IZE@2|Bacteria,2HDVT@201174|Actinobacteria	201174|Actinobacteria	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
MMS1_k127_912871_3	1397699.JNIS01000001_gene1905	1.387e-14	79.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TSQZ@1239|Firmicutes,4HCYZ@91061|Bacilli,3WF91@539002|Bacillales incertae sedis	91061|Bacilli	P	Metallo-beta-lactamase superfamily	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
MMS1_k127_914128_1	929704.Myrod_2210	1.846e-57	206.0	COG1061@1|root,COG1061@2|Bacteria,4NIHX@976|Bacteroidetes,1HXVR@117743|Flavobacteriia,47IMM@76831|Myroides	976|Bacteroidetes	V	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
MMS1_k127_914128_2	313628.LNTAR_02794	1.492e-31	129.0	28U9I@1|root,2ZGF2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_914128_0	1322246.BN4_11470	1.101e-131	437.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_4,PAS_9,Response_reg,dCache_2
MMS1_k127_91524_4	324057.Pjdr2_1991	4.789e-47	177.0	COG1653@1|root,COG1653@2|Bacteria,1TPBS@1239|Firmicutes,4IPRZ@91061|Bacilli,26UKJ@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter substrate-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_91524_3	1163671.JAGI01000001_gene242	5.642e-106	355.0	COG4225@1|root,COG4225@2|Bacteria,1TS2C@1239|Firmicutes,249FU@186801|Clostridia,36H86@31979|Clostridiaceae	186801|Clostridia	S	PFAM Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
MMS1_k127_91524_2	1449063.JMLS01000011_gene326	1.157e-134	437.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,26RIC@186822|Paenibacillaceae	91061|Bacilli	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS1_k127_91524_0	1449063.JMLS01000011_gene327	1.226e-141	456.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26SF5@186822|Paenibacillaceae	91061|Bacilli	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS1_k127_91524_1	1408424.JHYI01000014_gene1254	1.314e-135	441.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4H9PZ@91061|Bacilli,1ZC9B@1386|Bacillus	91061|Bacilli	EP	COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034,ko:K15582,ko:K16201	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00566	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.2,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
MMS1_k127_920471_1	1304885.AUEY01000091_gene1630	1.718e-157	518.0	COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MITZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3
MMS1_k127_920471_0	1168289.AJKI01000010_gene1545	1.817e-223	728.0	COG0383@1|root,COG0383@2|Bacteria,4NJ12@976|Bacteroidetes,2FNHX@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 38 C-terminal domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,F5_F8_type_C,Glyco_hydro_38,Glyco_hydro_38C
MMS1_k127_920471_2	158190.SpiGrapes_2320	2.013e-50	190.0	COG2211@1|root,COG2211@2|Bacteria,2J6VC@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter	-	-	-	ko:K11104,ko:K16209,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2,2.A.2.1,2.A.2.2	-	-	MFS_2
MMS1_k127_922165_2	1480694.DC28_10295	1.874e-81	293.0	COG0840@1|root,COG0840@2|Bacteria,2J81D@203691|Spirochaetes	203691|Spirochaetes	NT	transmembrane signaling receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_922165_0	889378.Spiaf_2461	2.766e-172	546.0	COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
MMS1_k127_922165_4	744872.Spica_2385	2.348e-43	173.0	COG1653@1|root,COG1653@2|Bacteria,2J5NC@203691|Spirochaetes	203691|Spirochaetes	G	transport	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
MMS1_k127_922165_1	1123274.KB899408_gene3911	4.066e-84	289.0	COG1242@1|root,COG1242@2|Bacteria,2J6Y8@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM radical SAM protein, TIGR01212 family	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
MMS1_k127_922165_5	545695.TREAZ_3455	2.605e-28	120.0	2AMDJ@1|root,31C90@2|Bacteria,2J6DK@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_922165_6	391613.RTM1035_10565	2.214e-07	57.0	COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,2UT6H@28211|Alphaproteobacteria,46R6R@74030|Roseovarius	28211|Alphaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
MMS1_k127_922165_3	744872.Spica_2482	6.08e-50	188.0	COG1600@1|root,COG1600@2|Bacteria,2JAKM@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Fer4_16
MMS1_k127_923646_1	357276.EL88_09790	4.283e-08	66.0	COG0457@1|root,COG0457@2|Bacteria,4NERG@976|Bacteroidetes,2FMK5@200643|Bacteroidia,4AK7T@815|Bacteroidaceae	976|Bacteroidetes	S	COG NOG06393 non supervised orthologous group	batD	-	-	-	-	-	-	-	-	-	-	-	BatD,TPR_2
MMS1_k127_923646_0	595460.RRSWK_02633	6.408e-16	87.0	COG0457@1|root,COG0457@2|Bacteria,2J18X@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_924649_1	316274.Haur_2171	2.015e-54	200.0	COG2197@1|root,COG2197@2|Bacteria,2G6K1@200795|Chloroflexi,376D3@32061|Chloroflexia	32061|Chloroflexia	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
MMS1_k127_924649_3	316274.Haur_2170	8.083e-38	157.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
MMS1_k127_924649_2	744872.Spica_2024	8.419e-42	167.0	COG0845@1|root,COG0845@2|Bacteria,2J88F@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
MMS1_k127_924649_0	545694.TREPR_0547	3.884e-62	228.0	COG0841@1|root,COG0841@2|Bacteria,2J6SF@203691|Spirochaetes	203691|Spirochaetes	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS1_k127_925147_3	1122962.AULH01000008_gene2271	1.481e-09	60.0	COG0169@1|root,COG0169@2|Bacteria,1R48I@1224|Proteobacteria,2TRNZ@28211|Alphaproteobacteria,371C8@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Shikimate dehydrogenase substrate binding domain	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS1_k127_925147_1	1540257.JQMW01000009_gene3836	1.954e-79	274.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,36E2P@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
MMS1_k127_925147_2	1415775.U729_2401	1.291e-52	194.0	COG1349@1|root,COG1349@2|Bacteria,1TNYH@1239|Firmicutes,24BT5@186801|Clostridia,36GFV@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, DeoR	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
MMS1_k127_925147_0	1499967.BAYZ01000190_gene3814	3.986e-236	742.0	COG1882@1|root,COG1882@2|Bacteria	2|Bacteria	C	formate C-acetyltransferase activity	ybiW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
MMS1_k127_926229_1	1450694.BTS2_2429	3.188e-13	78.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,1ZBEA@1386|Bacillus	91061|Bacilli	NT	chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,MCPsignal
MMS1_k127_926229_0	1121422.AUMW01000007_gene3113	1.055e-68	249.0	COG2200@1|root,COG2200@2|Bacteria,1UY3J@1239|Firmicutes,25B36@186801|Clostridia,261A1@186807|Peptococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL
MMS1_k127_929144_0	574087.Acear_0362	1.164e-31	132.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3WAC6@53433|Halanaerobiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_7,Fer4_9,NQRA_SLBB,RnfC_N
MMS1_k127_929144_1	754476.Q7A_1045	1.366e-31	133.0	293CN@1|root,2Z9VJ@2|Bacteria,1MXNG@1224|Proteobacteria,1RZCQ@1236|Gammaproteobacteria,463I1@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_929144_2	1347368.HG964405_gene5999	7.992e-20	100.0	COG0640@1|root,COG0640@2|Bacteria,1UV7X@1239|Firmicutes,4I4FX@91061|Bacilli,1ZKGE@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
MMS1_k127_930676_2	926569.ANT_22730	2.196e-51	195.0	COG0697@1|root,COG0697@2|Bacteria,2G70T@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_930676_0	931276.Cspa_c22720	5.152e-89	300.0	2BGI2@1|root,32AGA@2|Bacteria,1V9HA@1239|Firmicutes,24DJR@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mpv17_PMP22
MMS1_k127_930676_4	1123228.AUIH01000070_gene2644	1.402e-13	79.0	COG1344@1|root,COG1344@2|Bacteria,1MWE0@1224|Proteobacteria,1RYAM@1236|Gammaproteobacteria,1XKJZ@135619|Oceanospirillales	135619|Oceanospirillales	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	-	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
MMS1_k127_930676_1	439235.Dalk_0542	1.362e-77	269.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG4936@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1,sCache_2
MMS1_k127_930676_3	880073.Calab_3134	1.237e-18	87.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,HisKA_2,PAS_3,PAS_4,PAS_9,Response_reg
MMS1_k127_931077_10	573061.Clocel_4218	6.814e-10	60.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae	186801|Clostridia	K	aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMS1_k127_931077_1	1307761.L21SP2_0517	2.936e-100	338.0	COG3675@1|root,COG3675@2|Bacteria	2|Bacteria	I	Lipase (class 3)	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_3
MMS1_k127_931077_0	1392491.JIAE01000001_gene1979	2.155e-135	438.0	COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,3WHKM@541000|Ruminococcaceae	186801|Clostridia	G	Kinase, PfkB family	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
MMS1_k127_931077_2	877418.ATWV01000005_gene2633	4.442e-76	260.0	COG0800@1|root,COG0800@2|Bacteria,2J6B8@203691|Spirochaetes	203691|Spirochaetes	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
MMS1_k127_931077_6	476272.RUMHYD_00696	7.749e-25	113.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,3XZSI@572511|Blautia	186801|Clostridia	K	Psort location Cytoplasmic, score 8.87	kdgR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
MMS1_k127_931077_9	762966.HMPREF9439_01594	2.093e-12	68.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,4PR8Z@995019|Sutterellaceae	28216|Betaproteobacteria	S	Thioesterase-like superfamily	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS1_k127_931077_5	573413.Spirs_3561	3.352e-57	215.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	yihR	GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
MMS1_k127_931077_3	338966.Ppro_2428	4.417e-61	226.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2WM9T@28221|Deltaproteobacteria,43UPQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
MMS1_k127_931077_4	889378.Spiaf_1047	6.206e-59	213.0	COG0204@1|root,COG0204@2|Bacteria,2J9F7@203691|Spirochaetes	203691|Spirochaetes	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
MMS1_k127_931077_7	396588.Tgr7_0876	6.646e-14	73.0	2EIC1@1|root,33C3D@2|Bacteria,1NH77@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_931077_8	639282.DEFDS_1799	8.17e-14	73.0	COG0488@1|root,COG0488@2|Bacteria,2GFC2@200930|Deferribacteres	200930|Deferribacteres	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
MMS1_k127_931492_1	1207063.P24_02111	1.052e-71	255.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,2JPY6@204441|Rhodospirillales	204441|Rhodospirillales	L	COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
MMS1_k127_931492_2	1307761.L21SP2_2730	7.615e-28	115.0	COG0760@1|root,COG0760@2|Bacteria,2J7Z8@203691|Spirochaetes	203691|Spirochaetes	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
MMS1_k127_931492_0	889378.Spiaf_0685	2.496e-156	500.0	COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,2J6PF@203691|Spirochaetes	203691|Spirochaetes	GT	Pts system, fructose-specific	fruA-2	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
MMS1_k127_932694_0	1536770.R50345_21825	2.482e-92	315.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,4HCXP@91061|Bacilli,275ME@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 65 central catalytic domain	-	-	2.4.1.279	ko:K18783	-	-	R09941	RC00049	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
MMS1_k127_932694_1	86416.Clopa_3945	4.085e-78	267.0	COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia,36GZ2@31979|Clostridiaceae	186801|Clostridia	S	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	pgmB	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS1_k127_932694_2	1480694.DC28_03335	4.086e-20	93.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS1_k127_933581_2	545694.TREPR_0145	6.575e-11	68.0	COG0349@1|root,COG0349@2|Bacteria,2J80E@203691|Spirochaetes	203691|Spirochaetes	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
MMS1_k127_933581_0	180332.JTGN01000002_gene5481	2.72e-149	481.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17,Fer4_9
MMS1_k127_933581_1	1414720.CBYM010000020_gene2483	1.11e-44	170.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,24C9U@186801|Clostridia,36H0I@31979|Clostridiaceae	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
MMS1_k127_935681_2	1499968.TCA2_3653	6.612e-05	46.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,26QQ1@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
MMS1_k127_935681_0	452637.Oter_4335	4.36e-140	461.0	COG0685@1|root,COG0685@2|Bacteria,46TD1@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
MMS1_k127_935681_1	177437.HRM2_33880	1.448e-25	111.0	2C5Z2@1|root,32U5Z@2|Bacteria,1N4MT@1224|Proteobacteria,42TX0@68525|delta/epsilon subdivisions,2WQZM@28221|Deltaproteobacteria,2MKYF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
MMS1_k127_936115_2	931626.Awo_c32020	4.712e-21	104.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1V0ZY@1239|Firmicutes,25BQS@186801|Clostridia	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K21701	-	-	-	-	ko00000,ko03000	-	-	-	AraC_binding,HTH_AraC
MMS1_k127_936115_1	1123274.KB899412_gene1435	1.419e-56	202.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	mop	-	1.2.5.3,1.2.99.7,1.3.99.16	ko:K03518,ko:K07302,ko:K07469	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
MMS1_k127_936115_0	1123274.KB899412_gene1434	5.026e-104	344.0	COG1529@1|root,COG1529@2|Bacteria,2J727@203691|Spirochaetes	203691|Spirochaetes	C	aldehyde oxidase and xanthine dehydrogenase a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
MMS1_k127_936785_5	1511.CLOST_1973	2.599e-18	96.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
MMS1_k127_936785_2	596323.HMPREF0554_0379	1.507e-42	163.0	COG1011@1|root,COG1011@2|Bacteria,37A6M@32066|Fusobacteria	32066|Fusobacteria	S	IA, variant 3	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS1_k127_936785_4	1507.HMPREF0262_00919	1.431e-30	132.0	COG3238@1|root,COG3238@2|Bacteria,1VAM8@1239|Firmicutes,25CV0@186801|Clostridia,36X15@31979|Clostridiaceae	186801|Clostridia	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
MMS1_k127_936785_0	445973.CLOBAR_01665	2.222e-49	184.0	COG0664@1|root,COG0664@2|Bacteria,1UEKS@1239|Firmicutes,25CK2@186801|Clostridia,25UMQ@186804|Peptostreptococcaceae	186801|Clostridia	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
MMS1_k127_936785_3	1027273.GZ77_03620	8.475e-34	139.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DA1-like,Guanylate_cyc,HAMP,LIM
MMS1_k127_936785_1	906968.Trebr_0929	6.808e-44	175.0	COG3206@1|root,COG3206@2|Bacteria,2J5HM@203691|Spirochaetes	203691|Spirochaetes	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
MMS1_k127_937114_0	1121403.AUCV01000013_gene3923	4.017e-158	503.0	COG1900@1|root,COG1900@2|Bacteria,1NTA1@1224|Proteobacteria,42Z5S@68525|delta/epsilon subdivisions,2WTIA@28221|Deltaproteobacteria,2MN0J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
MMS1_k127_937114_1	1167006.UWK_01143	2.218e-56	205.0	COG0607@1|root,COG0607@2|Bacteria,1PE42@1224|Proteobacteria,42V5T@68525|delta/epsilon subdivisions,2WSQG@28221|Deltaproteobacteria,2MNFY@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Rhodanese
MMS1_k127_937318_5	573413.Spirs_0396	1.616e-19	89.0	COG1848@1|root,COG1848@2|Bacteria,2J7R7@203691|Spirochaetes	203691|Spirochaetes	S	SPTR PIN domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_3
MMS1_k127_937318_1	573413.Spirs_3699	1.485e-224	706.0	COG1384@1|root,COG1384@2|Bacteria,2J5WX@203691|Spirochaetes	203691|Spirochaetes	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f,tRNA-synt_1g
MMS1_k127_937318_3	573413.Spirs_3724	7.955e-92	317.0	COG4773@1|root,COG4773@2|Bacteria,2JBCN@203691|Spirochaetes	2|Bacteria	P	Receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug
MMS1_k127_937318_2	573413.Spirs_3723	7.641e-98	325.0	COG3026@1|root,COG3026@2|Bacteria,2J61M@203691|Spirochaetes	203691|Spirochaetes	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
MMS1_k127_937318_0	573413.Spirs_3722	3.223e-259	826.0	COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes	203691|Spirochaetes	S	COGs COG1033 exporter of the RND superfamily protein	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
MMS1_k127_937318_4	573413.Spirs_3721	5.266e-52	191.0	COG1309@1|root,COG1309@2|Bacteria,2J95Q@203691|Spirochaetes	203691|Spirochaetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
MMS1_k127_937318_6	717231.Flexsi_1152	8.249e-18	88.0	COG0071@1|root,COG0071@2|Bacteria,2GFNR@200930|Deferribacteres	200930|Deferribacteres	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMS1_k127_942939_0	1129794.C427_2793	2.252e-152	491.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,464WF@72275|Alteromonadaceae	1236|Gammaproteobacteria	JKL	DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
MMS1_k127_942939_3	1307761.L21SP2_2008	2.093e-82	280.0	COG2935@1|root,COG2935@2|Bacteria	2|Bacteria	O	arginyltransferase activity	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C
MMS1_k127_942939_1	1232437.KL661961_gene3046	4.363e-91	309.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions,2WJ2Y@28221|Deltaproteobacteria,2MKZK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS1_k127_942939_2	573061.Clocel_4117	2.137e-89	302.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,36DZN@31979|Clostridiaceae	186801|Clostridia	L	Formamidopyrimidine-DNA glycosylase H2TH domain	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
MMS1_k127_943249_0	1121428.DESHY_150005___1	3.735e-124	410.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,26059@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
MMS1_k127_943249_1	265729.GS18_0215575	6.441e-45	176.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,4HC6U@91061|Bacilli,1ZBJU@1386|Bacillus	91061|Bacilli	E	Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity	mcsB	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
MMS1_k127_943249_2	545695.TREAZ_0014	4.018e-36	143.0	COG4591@1|root,COG4591@2|Bacteria,2J5WV@203691|Spirochaetes	203691|Spirochaetes	M	Permease protein	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
MMS1_k127_94645_1	1125863.JAFN01000001_gene1558	0.0002889	53.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N5C@68525|delta/epsilon subdivisions,2WM18@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg
MMS1_k127_94645_0	1536774.H70357_15905	7.742e-40	158.0	COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,4HDUH@91061|Bacilli,26VE0@186822|Paenibacillaceae	91061|Bacilli	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS1_k127_948249_3	573413.Spirs_2362	3.424e-24	105.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
MMS1_k127_948249_5	1319815.HMPREF0202_00777	2.937e-18	87.0	COG4807@1|root,COG4807@2|Bacteria,379XJ@32066|Fusobacteria	32066|Fusobacteria	S	Protein of unknown function (DUF1456)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1456
MMS1_k127_948249_0	1480694.DC28_11095	2.17e-142	471.0	COG0323@1|root,COG0323@2|Bacteria,2J5XE@203691|Spirochaetes	203691|Spirochaetes	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
MMS1_k127_948249_1	573413.Spirs_2360	8.48e-140	470.0	COG4254@1|root,COG4254@2|Bacteria,2J9KS@203691|Spirochaetes	203691|Spirochaetes	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
MMS1_k127_948249_2	573413.Spirs_2359	4.858e-79	282.0	COG4254@1|root,COG4254@2|Bacteria,2J99I@203691|Spirochaetes	203691|Spirochaetes	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_948249_4	1123274.KB899424_gene2999	7.245e-20	105.0	COG0389@1|root,COG0389@2|Bacteria,2J5NZ@203691|Spirochaetes	203691|Spirochaetes	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_948422_1	1307761.L21SP2_3129	2.522e-55	203.0	COG0472@1|root,COG0472@2|Bacteria,2J69N@203691|Spirochaetes	203691|Spirochaetes	M	Glycosyl transferase, family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
MMS1_k127_948422_0	1125699.HMPREF9194_00982	1.626e-60	226.0	2EQUJ@1|root,33IEB@2|Bacteria,2JBG7@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_948786_1	744872.Spica_0362	4.715e-12	79.0	COG0741@1|root,COG0741@2|Bacteria,2J7A5@203691|Spirochaetes	203691|Spirochaetes	M	transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_6
MMS1_k127_948786_0	1123274.KB899410_gene3462	4.473e-102	345.0	COG0457@1|root,COG0457@2|Bacteria,2J5RJ@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
MMS1_k127_950861_0	237368.SCABRO_02223	2.222e-132	429.0	COG0714@1|root,COG0714@2|Bacteria,2IX23@203682|Planctomycetes	203682|Planctomycetes	S	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_950861_1	237368.SCABRO_01880	9.208e-91	307.0	COG1721@1|root,COG1721@2|Bacteria,2IXT7@203682|Planctomycetes	203682|Planctomycetes	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS1_k127_95157_5	574087.Acear_0364	2.009e-18	88.0	COG2869@1|root,COG2869@2|Bacteria	2|Bacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
MMS1_k127_95157_1	660470.Theba_0831	1.394e-58	209.0	COG1347@1|root,COG1347@2|Bacteria,2GCJ2@200918|Thermotogae	200918|Thermotogae	C	Belongs to the NqrDE RnfAE family	-	-	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
MMS1_k127_95157_0	574087.Acear_0366	6.958e-66	229.0	COG2209@1|root,COG2209@2|Bacteria	2|Bacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
MMS1_k127_95157_3	158189.SpiBuddy_2061	3.856e-26	114.0	COG2871@1|root,COG2871@2|Bacteria,2J8WH@203691|Spirochaetes	203691|Spirochaetes	C	Oxidoreductase FAD-binding domain	-	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
MMS1_k127_95157_2	386456.JQKN01000009_gene1127	5.575e-43	161.0	COG1905@1|root,arCOG04890@2157|Archaea,2XYS3@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
MMS1_k127_95157_4	398512.JQKC01000016_gene2854	2.414e-20	94.0	COG4109@1|root,COG4109@2|Bacteria,1VA3T@1239|Firmicutes,24MQM@186801|Clostridia,3WJAV@541000|Ruminococcaceae	186801|Clostridia	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
MMS1_k127_95157_6	665571.STHERM_c13810	1.39e-05	52.0	COG2172@1|root,COG2524@1|root,COG2172@2|Bacteria,COG2524@2|Bacteria,2J63A@203691|Spirochaetes	203691|Spirochaetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c
MMS1_k127_951677_2	665571.STHERM_c14540	1.213e-56	207.0	COG0569@1|root,COG0569@2|Bacteria,2J59W@203691|Spirochaetes	203691|Spirochaetes	C	Trk system potassium uptake protein TrkA	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
MMS1_k127_951677_1	639282.DEFDS_1538	9.528e-192	612.0	COG0168@1|root,COG0168@2|Bacteria,2GEUM@200930|Deferribacteres	200930|Deferribacteres	P	Cation transport protein	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMS1_k127_951677_0	338963.Pcar_2072	6.576e-231	735.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,43U9J@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	THUMP	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
MMS1_k127_952459_0	1123274.KB899418_gene2305	2.03e-180	576.0	28I3G@1|root,2Z7IH@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2586)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2586
MMS1_k127_952459_3	411483.FAEPRAA2165_03413	9.159e-05	48.0	2EQZZ@1|root,338Z9@2|Bacteria,1VJJW@1239|Firmicutes,24QYR@186801|Clostridia,3WQYT@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_956043_0	573413.Spirs_3660	1.774e-107	369.0	COG1026@1|root,COG1026@2|Bacteria,2J67R@203691|Spirochaetes	203691|Spirochaetes	S	peptidase, M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
MMS1_k127_956876_0	227377.CBU_0930	3.013e-67	237.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,1S9CM@1236|Gammaproteobacteria,1JD7P@118969|Legionellales	118969|Legionellales	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
MMS1_k127_956876_1	1307761.L21SP2_2373	2.156e-26	113.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM_1	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
MMS1_k127_957555_1	1123274.KB899406_gene1148	5.406e-60	220.0	COG1609@1|root,COG1609@2|Bacteria,2J6RM@203691|Spirochaetes	203691|Spirochaetes	K	PFAM Bacterial regulatory proteins, lacI family	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_4
MMS1_k127_957555_0	411461.DORFOR_01281	5.481e-225	708.0	COG1070@1|root,COG1070@2|Bacteria,1TP91@1239|Firmicutes,24A4Z@186801|Clostridia,27UX7@189330|Dorea	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	araB	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
MMS1_k127_960807_4	1480694.DC28_00730	7.96e-69	250.0	2F2JP@1|root,33VGK@2|Bacteria,2J6EC@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_960807_2	1480694.DC28_00735	2.299e-152	493.0	COG1160@1|root,COG1160@2|Bacteria,2J5GG@203691|Spirochaetes	203691|Spirochaetes	I	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
MMS1_k127_960807_1	744872.Spica_2561	1.616e-194	623.0	COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes	203691|Spirochaetes	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
MMS1_k127_960807_7	889378.Spiaf_1973	1.839e-40	161.0	COG5401@1|root,COG5401@2|Bacteria,2J7JQ@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
MMS1_k127_960807_5	573413.Spirs_3212	2.709e-54	198.0	COG1189@1|root,COG1189@2|Bacteria,2J8G3@203691|Spirochaetes	203691|Spirochaetes	J	TIGRFAM hemolysin TlyA family protein	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
MMS1_k127_960807_3	760011.Spico_1688	3.027e-92	311.0	COG1692@1|root,COG1692@2|Bacteria,2J7C4@203691|Spirochaetes	203691|Spirochaetes	S	metallophosphoesterase	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
MMS1_k127_960807_0	744872.Spica_2759	6.607e-227	712.0	COG1418@1|root,COG1418@2|Bacteria,2J5IM@203691|Spirochaetes	203691|Spirochaetes	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
MMS1_k127_960807_8	665571.STHERM_c05230	8.681e-12	78.0	COG3064@1|root,COG3064@2|Bacteria,2J6Q1@203691|Spirochaetes	203691|Spirochaetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_960807_6	545694.TREPR_0713	1.525e-41	172.0	COG3064@1|root,COG3064@2|Bacteria,2J6Q1@203691|Spirochaetes	203691|Spirochaetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_962051_0	870967.VIS19158_14582	4.369e-155	497.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,1S1VG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,HTH_17,SHOCT
MMS1_k127_962051_1	313628.LNTAR_24556	5.795e-80	275.0	COG1996@1|root,COG1996@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_963202_0	1150600.ADIARSV_3160	8.278e-103	343.0	COG3261@1|root,COG3261@2|Bacteria,4P295@976|Bacteroidetes	976|Bacteroidetes	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
MMS1_k127_963202_1	1150600.ADIARSV_3159	5.583e-92	308.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ehrS	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2596	Fer4,Fer4_15,Fer4_7,Oxidored_q6
MMS1_k127_963202_2	904296.HMPREF9124_0048	7.723e-15	84.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,2PT07@265975|Oribacterium	186801|Clostridia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
MMS1_k127_964481_0	69319.XP_008556212.1	4.649e-27	129.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria,41TUY@6656|Arthropoda,3SH8U@50557|Insecta,46GVX@7399|Hymenoptera	33208|Metazoa	M	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,PRANC
MMS1_k127_969635_2	760011.Spico_1061	2.769e-28	118.0	COG5026@1|root,COG5026@2|Bacteria,2J6A7@203691|Spirochaetes	203691|Spirochaetes	G	hexokinase	-	-	2.7.1.1	ko:K00844	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04910,ko04930,ko04973,ko05230,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200,map04066,map04910,map04930,map04973,map05230	M00001,M00549	R00299,R00760,R00867,R01326,R01600,R01786,R01961,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	Hexokinase_1,Hexokinase_2
MMS1_k127_969635_0	1292035.H476_3304	6.538e-59	211.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,25RPM@186804|Peptostreptococcaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
MMS1_k127_969635_3	112098.XP_008614838.1	1.179e-09	70.0	COG0515@1|root,COG0666@1|root,KOG0192@2759|Eukaryota,KOG1187@2759|Eukaryota,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4,LRR_6,Pkinase,Pkinase_Tyr
MMS1_k127_969635_4	1122176.KB903547_gene1124	6.019e-06	58.0	2C5KE@1|root,34BX7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_969635_1	1122599.AUGR01000005_gene1821	1.122e-47	179.0	COG2733@1|root,COG2733@2|Bacteria,1R4JT@1224|Proteobacteria,1RRVB@1236|Gammaproteobacteria,1XJFH@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_972208_3	665571.STHERM_c17700	3.735e-59	214.0	COG0508@1|root,COG0508@2|Bacteria,2J5U3@203691|Spirochaetes	203691|Spirochaetes	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
MMS1_k127_972208_0	1265505.ATUG01000001_gene3215	7.749e-181	585.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS1_k127_972208_1	759914.BP951000_1336	7.357e-70	246.0	COG0053@1|root,COG0053@2|Bacteria,2J6IT@203691|Spirochaetes	203691|Spirochaetes	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
MMS1_k127_972208_7	1385520.N802_11525	0.0006651	43.0	COG0454@1|root,COG0456@2|Bacteria,2INVM@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
MMS1_k127_972208_2	1196322.A370_04803	1.325e-69	241.0	COG0778@1|root,COG0778@2|Bacteria,1V7AA@1239|Firmicutes,25B3R@186801|Clostridia,36W8B@31979|Clostridiaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS1_k127_972208_5	536227.CcarbDRAFT_0486	5.363e-34	135.0	COG1846@1|root,COG1846@2|Bacteria,1VB3Q@1239|Firmicutes,25CPU@186801|Clostridia,36WYX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS1_k127_972208_4	525897.Dbac_0604	5.643e-44	166.0	COG0500@1|root,COG0500@2|Bacteria,1QXX1@1224|Proteobacteria,43CRG@68525|delta/epsilon subdivisions,2X7Z5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_972208_6	626939.HMPREF9443_00336	3.696e-19	91.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
MMS1_k127_976522_2	665571.STHERM_c00420	1.006e-61	222.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	2|Bacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS1_k127_976522_1	573413.Spirs_0140	2.478e-98	323.0	COG1366@1|root,COG1366@2|Bacteria,2J6J8@203691|Spirochaetes	203691|Spirochaetes	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS
MMS1_k127_976522_3	679937.Bcop_0188	4.609e-11	71.0	COG0745@1|root,COG0745@2|Bacteria,4NE77@976|Bacteroidetes,2FMWQ@200643|Bacteroidia,4ATW4@815|Bacteroidaceae	976|Bacteroidetes	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS1_k127_976522_0	573413.Spirs_0147	7.402e-161	511.0	COG0766@1|root,COG0766@2|Bacteria,2J5JB@203691|Spirochaetes	203691|Spirochaetes	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
MMS1_k127_982357_3	1123274.KB899438_gene662	1.351e-13	73.0	COG1018@1|root,COG1018@2|Bacteria	2|Bacteria	C	nitric oxide dioxygenase activity	-	-	1.14.12.17	ko:K02639,ko:K05916	ko00195,ko05132,map00195,map05132	-	-	-	ko00000,ko00001,ko00194,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
MMS1_k127_982357_0	1123274.KB899438_gene663	7.017e-235	731.0	COG0399@1|root,COG0399@2|Bacteria,2J76G@203691|Spirochaetes	203691|Spirochaetes	M	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
MMS1_k127_982357_1	1123274.KB899438_gene664	5.033e-144	459.0	COG1208@1|root,COG1208@2|Bacteria,2J6IF@203691|Spirochaetes	203691|Spirochaetes	M	Glucose-1-phosphate cytidylyltransferase	rfbF	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
MMS1_k127_982357_2	243924.LT42_22410	2.691e-37	143.0	COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,1RMKK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	CDP-glucose 4,6-dehydratase	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
MMS1_k127_990031_2	555779.Dthio_PD3748	1.919e-18	100.0	COG0642@1|root,COG2205@2|Bacteria,1R7R8@1224|Proteobacteria,42NER@68525|delta/epsilon subdivisions,2WUV0@28221|Deltaproteobacteria,2M8RU@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HATPase_c,HisKA,MASE3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
MMS1_k127_990031_1	28072.Nos7524_1845	7.131e-21	108.0	COG0517@1|root,COG0745@1|root,COG2202@1|root,COG3852@1|root,COG5000@1|root,COG0517@2|Bacteria,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3852@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria	1117|Cyanobacteria	T	TIGRFAM PAS domain S-box	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
MMS1_k127_990031_4	456442.Mboo_1426	2.417e-10	68.0	arCOG11331@1|root,arCOG11331@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
MMS1_k127_990031_0	483219.LILAB_16440	7.285e-24	111.0	COG3672@1|root,COG3672@2|Bacteria	2|Bacteria	O	Periplasmic Protein	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Peptidase_C93
MMS1_k127_990031_3	684949.ATTJ01000002_gene16	3.19e-12	66.0	COG1064@1|root,COG1064@2|Bacteria	2|Bacteria	P	alcohol dehydrogenase	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_994037_0	573413.Spirs_2017	1.428e-108	370.0	COG2255@1|root,COG2255@2|Bacteria,2J5IU@203691|Spirochaetes	203691|Spirochaetes	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
## 4791 queries scanned
## Total time (seconds): 266.00074887275696
## Rate: 18.01 q/s