## Sat Nov 16 01:51:49 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin16/MMS_1_bin.74.fa -m mmseqs --itype genome -o MMS_1_bin.74 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_1_bin.74 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS1_k127_1003738_4	272844.PAB0190	1.314e-16	82.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
MMS1_k127_1003738_1	1041930.Mtc_1754	9.991e-49	183.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
MMS1_k127_1003738_3	579137.Metvu_0186	2.972e-23	102.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,23QZQ@183939|Methanococci	183939|Methanococci	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	eif1a	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
MMS1_k127_1003738_2	1236689.MMALV_03220	2.108e-28	118.0	COG1601@1|root,COG3269@1|root,arCOG01640@2157|Archaea,arCOG01641@2157|Archaea,2XTVZ@28890|Euryarchaeota,3F2N9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
MMS1_k127_1003738_5	1227454.C446_08826	2.905e-07	63.0	COG0582@1|root,arCOG01242@2157|Archaea,2XUNK@28890|Euryarchaeota,23UT9@183963|Halobacteria	183963|Halobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
MMS1_k127_1003738_0	192952.MM_0190	6.71e-68	239.0	COG0210@1|root,arCOG00798@2157|Archaea,2Y7MZ@28890|Euryarchaeota,2NANX@224756|Methanomicrobia	224756|Methanomicrobia	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS1_k127_1071524_0	273116.14324307	3.016e-196	628.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,24226@183967|Thermoplasmata	183967|Thermoplasmata	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS1_k127_1071524_41	1122182.KB903833_gene5326	1.268e-19	98.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,4D8Y3@85008|Micromonosporales	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
MMS1_k127_1071524_33	7668.SPU_014738-tr	7.382e-36	147.0	2CY1N@1|root,2S1C2@2759|Eukaryota,3A4T1@33154|Opisthokonta,3BRGB@33208|Metazoa,3D8WT@33213|Bilateria	33208|Metazoa	S	YHYH protein	-	-	-	-	-	-	-	-	-	-	-	-	YHYH
MMS1_k127_1071524_4	1382306.JNIM01000001_gene2102	9.059e-136	440.0	COG1063@1|root,COG1063@2|Bacteria,2G7RW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
MMS1_k127_1071524_23	1500301.JQMF01000024_gene2043	4.036e-50	185.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2VG87@28211|Alphaproteobacteria,4BNHK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
MMS1_k127_1071524_28	399549.Msed_1442	2.828e-45	173.0	COG0500@1|root,arCOG02702@2157|Archaea,2XREM@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Nitro_FeMo-Co
MMS1_k127_1071524_9	351607.Acel_0150	6.598e-91	310.0	COG1575@1|root,COG1575@2|Bacteria,2GJBS@201174|Actinobacteria,4ESBC@85013|Frankiales	201174|Actinobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS1_k127_1071524_11	397948.Cmaq_1702	2.834e-85	297.0	COG0025@1|root,arCOG01961@2157|Archaea	2157|Archaea	P	COG0025 NhaP-type Na H and K H antiporters	kef1	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
MMS1_k127_1071524_18	573063.Metin_1432	3.378e-58	219.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,23QBC@183939|Methanococci	183939|Methanococci	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMS1_k127_1071524_44	339860.Msp_0589	3.42e-16	86.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,23P4V@183925|Methanobacteria	183925|Methanobacteria	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMS1_k127_1071524_53	490899.DKAM_1126	8.491e-06	57.0	arCOG05924@1|root,arCOG05924@2157|Archaea,2XRA9@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1071524_52	416348.Hlac_1587	7.525e-06	49.0	arCOG06415@1|root,arCOG06415@2157|Archaea	2157|Archaea	L	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	zf-HIT
MMS1_k127_1071524_21	387631.Asulf_01800	3.146e-51	187.0	COG0377@1|root,arCOG01554@2157|Archaea,2XTP1@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the complex I 20 kDa subunit family	nuoB	-	1.5.98.3,1.6.5.3	ko:K00331,ko:K22159	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Oxidored_q6
MMS1_k127_1071524_49	648996.Theam_0733	1.801e-09	63.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	ndhJ	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044464,GO:0045333,GO:0050136,GO:0055114,GO:0071944	1.6.5.3	ko:K00332,ko:K05581,ko:K13378	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhJ	Complex1_30kDa,Complex1_49kDa
MMS1_k127_1071524_7	387631.Asulf_01802	3.139e-97	330.0	COG0649@1|root,arCOG01548@2157|Archaea,2XTWF@28890|Euryarchaeota,245Y0@183980|Archaeoglobi	28890|Euryarchaeota	C	NADH ubiquinone oxidoreductase 49 kD subunit 7	nuoCD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
MMS1_k127_1071524_22	637905.SVI_1638	1.462e-50	192.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,2Q8MW@267890|Shewanellaceae	1236|Gammaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
MMS1_k127_1071524_45	266117.Rxyl_1197	3.647e-16	83.0	COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CQRQ@84995|Rubrobacteria	84995|Rubrobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
MMS1_k127_1071524_19	1408813.AYMG01000036_gene3291	1.168e-57	222.0	COG1009@1|root,COG1009@2|Bacteria,4NEBM@976|Bacteroidetes,1IQ9D@117747|Sphingobacteriia	976|Bacteroidetes	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
MMS1_k127_1071524_20	696369.KI912183_gene843	1.987e-54	208.0	COG1007@1|root,COG1007@2|Bacteria,1TR55@1239|Firmicutes,25ED8@186801|Clostridia,25ZY3@186807|Peptococcaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
MMS1_k127_1071524_54	415426.Hbut_0776	1.248e-05	50.0	COG4830@1|root,arCOG04305@2157|Archaea,2XQSV@28889|Crenarchaeota	28889|Crenarchaeota	J	Ribosomal protein S26e	rps26e	-	-	ko:K02976	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S26e
MMS1_k127_1071524_55	1343739.PAP_09655	0.0002481	49.0	COG1992@1|root,arCOG00021@2157|Archaea,2XT4Y@28890|Euryarchaeota,243AG@183968|Thermococci	183968|Thermococci	H	Thiamine-phosphate synthase	-	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,Terminase_5,ThiP_synth
MMS1_k127_1071524_1	273075.Ta0776	1.033e-161	519.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,241PE@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMS1_k127_1071524_3	269797.Mbar_A1642	6.353e-149	491.0	COG1796@1|root,arCOG00305@2157|Archaea,2XT14@28890|Euryarchaeota,2N90T@224756|Methanomicrobia	224756|Methanomicrobia	L	Helix-hairpin-helix domain	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMS1_k127_1071524_6	573064.Mefer_0206	6.63e-102	342.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS1_k127_1071524_32	420247.Msm_0640	2.54e-36	151.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,23NQY@183925|Methanobacteria	183925|Methanobacteria	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS1_k127_1071524_31	933801.Ahos_1018	1.507e-39	157.0	COG1226@1|root,arCOG01958@2157|Archaea	2157|Archaea	P	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
MMS1_k127_1071524_14	273075.Ta0027	1.365e-78	272.0	COG0656@1|root,arCOG01619@2157|Archaea	2157|Archaea	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	yafB	-	1.1.1.346	ko:K06222	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
MMS1_k127_1071524_56	653948.CCA16492	0.0004217	42.0	KOG0594@1|root,KOG0594@2759|Eukaryota	2759|Eukaryota	G	cyclin-dependent protein serine/threonine kinase activity	CDKB	GO:0000003,GO:0000082,GO:0000086,GO:0000278,GO:0000307,GO:0000902,GO:0003006,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004693,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006275,GO:0006325,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007049,GO:0007154,GO:0007165,GO:0007275,GO:0007346,GO:0008150,GO:0008152,GO:0008284,GO:0009058,GO:0009059,GO:0009653,GO:0009719,GO:0009725,GO:0009755,GO:0009790,GO:0009791,GO:0009793,GO:0009826,GO:0009888,GO:0009889,GO:0009934,GO:0009987,GO:0010016,GO:0010033,GO:0010103,GO:0010154,GO:0010374,GO:0010376,GO:0010389,GO:0010440,GO:0010444,GO:0010468,GO:0010556,GO:0010564,GO:0016043,GO:0016049,GO:0016301,GO:0016310,GO:0016569,GO:0016570,GO:0016572,GO:0016740,GO:0016772,GO:0016773,GO:0019219,GO:0019222,GO:0019538,GO:0022402,GO:0022414,GO:0022603,GO:0023052,GO:0030154,GO:0030332,GO:0031323,GO:0031326,GO:0032501,GO:0032502,GO:0032870,GO:0032875,GO:0032989,GO:0032991,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0042023,GO:0042127,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0044770,GO:0044772,GO:0044786,GO:0044839,GO:0044843,GO:0046483,GO:0046777,GO:0048316,GO:0048366,GO:0048367,GO:0048509,GO:0048518,GO:0048522,GO:0048589,GO:0048608,GO:0048646,GO:0048731,GO:0048825,GO:0048827,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051239,GO:0051276,GO:0051716,GO:0051726,GO:0060255,GO:0060560,GO:0061458,GO:0061695,GO:0065007,GO:0070887,GO:0071310,GO:0071495,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090329,GO:0090558,GO:0090626,GO:0090627,GO:0090698,GO:0097472,GO:0099402,GO:0140096,GO:1901360,GO:1901564,GO:1901576,GO:1901987,GO:1901990,GO:1902494,GO:1902554,GO:1902749,GO:1902806,GO:1902911,GO:1903047,GO:1990234,GO:2000026,GO:2000037,GO:2000112	2.7.11.22,2.7.11.23	ko:K02087,ko:K02206,ko:K07760	ko04068,ko04110,ko04114,ko04115,ko04151,ko04218,ko04540,ko04914,ko04934,ko05161,ko05162,ko05165,ko05168,ko05169,ko05200,ko05203,ko05215,ko05222,ko05226,map04068,map04110,map04114,map04115,map04151,map04218,map04540,map04914,map04934,map05161,map05162,map05165,map05168,map05169,map05200,map05203,map05215,map05222,map05226	M00692,M00693	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko03032,ko03036,ko04147	-	-	-	Pkinase
MMS1_k127_1071524_13	1408473.JHXO01000005_gene1726	2.695e-81	274.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,2FN7E@200643|Bacteroidia	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
MMS1_k127_1071524_10	930945.SiRe_0966	1.586e-86	300.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRH0@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1071524_47	1459636.NTE_03059	1.481e-14	74.0	arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1071524_5	273116.14325565	1.676e-103	351.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,241NG@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMS1_k127_1071524_2	273116.14325562	6.537e-152	495.0	COG0591@1|root,arCOG01316@2157|Archaea,2Y79Y@28890|Euryarchaeota,241YE@183967|Thermoplasmata	183967|Thermoplasmata	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	-
MMS1_k127_1071524_48	273116.14325563	2.328e-13	72.0	arCOG03694@1|root,arCOG03694@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
MMS1_k127_1071524_30	1071679.BG57_27065	6.61e-41	168.0	COG0438@1|root,COG0438@2|Bacteria,1MWSZ@1224|Proteobacteria,2VN89@28216|Betaproteobacteria,1K6BI@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMS1_k127_1071524_8	273075.Ta0147	1.713e-91	314.0	COG3408@1|root,arCOG03287@2157|Archaea,2XU8W@28890|Euryarchaeota	28890|Euryarchaeota	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
MMS1_k127_1071524_51	1121434.AULY01000006_gene875	4.376e-06	55.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2MAZS@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMS1_k127_1071524_50	714943.Mucpa_7167	4.54e-07	63.0	COG1208@1|root,COG3420@1|root,COG5184@1|root,COG5492@1|root,COG1208@2|Bacteria,COG3420@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,4NMRB@976|Bacteroidetes,1ITFX@117747|Sphingobacteriia	976|Bacteroidetes	P	Protein of unknown function (DUF3494)	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494,Flg_new
MMS1_k127_1071524_12	1536774.H70357_22890	6.923e-85	293.0	COG3214@1|root,COG3214@2|Bacteria,1UYQ5@1239|Firmicutes,4HE15@91061|Bacilli,26U3N@186822|Paenibacillaceae	91061|Bacilli	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS1_k127_1071524_40	105422.BBPM01000097_gene5227	1.787e-21	102.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria,2NIDX@228398|Streptacidiphilus	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
MMS1_k127_1071524_17	1121085.AUCI01000006_gene1440	1.447e-59	214.0	COG2132@1|root,COG2132@2|Bacteria,1TS46@1239|Firmicutes,4ITAE@91061|Bacilli,1ZG10@1386|Bacillus	91061|Bacilli	Q	Domain of unknown function (DUF4396)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4396
MMS1_k127_1071524_36	1321778.HMPREF1982_01883	1.057e-30	125.0	COG0537@1|root,COG1443@1|root,COG0537@2|Bacteria,COG1443@2|Bacteria,1V41D@1239|Firmicutes,24P77@186801|Clostridia	186801|Clostridia	I	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_7,NUDIX
MMS1_k127_1071524_26	485913.Krac_1995	5.301e-46	171.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS1_k127_1071524_27	1123073.KB899242_gene1305	1.24e-45	171.0	COG5646@1|root,COG5646@2|Bacteria,1QB2A@1224|Proteobacteria,1T6JI@1236|Gammaproteobacteria,1X7N4@135614|Xanthomonadales	135614|Xanthomonadales	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS1_k127_1071524_35	1101195.Meth11DRAFT_0268	8.238e-32	128.0	COG5646@1|root,COG5646@2|Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DUF1801
MMS1_k127_1071524_57	1459636.NTE_00654	0.0007889	49.0	arCOG08773@1|root,arCOG08773@2157|Archaea,41SNY@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1071524_39	386456.JQKN01000001_gene1755	1.668e-24	108.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,23PKF@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
MMS1_k127_1071524_58	573064.Mefer_0690	0.000877	44.0	COG0255@1|root,arCOG00785@2157|Archaea,2XZUQ@28890|Euryarchaeota,23R8P@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMS1_k127_1071524_34	1054217.TALC_01329	6.924e-32	133.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,241P0@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMS1_k127_1071524_43	579137.Metvu_0227	4.696e-17	91.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,23QU0@183939|Methanococci	183939|Methanococci	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMS1_k127_1071524_38	273063.STK_04260	5.433e-30	123.0	COG0185@1|root,arCOG04099@2157|Archaea,2XQBR@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMS1_k127_1071524_16	523850.TON_0069	2.037e-69	242.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,242MT@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
MMS1_k127_1071524_46	374847.Kcr_1489	2.274e-15	79.0	COG0089@1|root,arCOG04072@2157|Archaea	2157|Archaea	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMS1_k127_1071524_29	358396.C445_11267	8.681e-42	164.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,23SFS@183963|Halobacteria	183963|Halobacteria	J	Forms part of the polypeptide exit tunnel	rpl4lp	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMS1_k127_1071524_15	1220534.B655_1960	7.781e-77	268.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,23NMA@183925|Methanobacteria	183925|Methanobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMS1_k127_1071524_25	604354.TSIB_1186	3.353e-46	171.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,242MQ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMS1_k127_1071524_24	439481.Aboo_1245	1.847e-48	188.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,3F2IZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMS1_k127_1071524_37	523845.AQXV01000025_gene1487	1.307e-30	124.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,23QZN@183939|Methanococci	183939|Methanococci	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMS1_k127_1071524_42	105422.BBPM01000006_gene5926	1.272e-17	95.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2NFQM@228398|Streptacidiphilus	201174|Actinobacteria	M	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,HemolysinCabind,Lactonase,TIG
MMS1_k127_1126226_1	70601.3257745	2.578e-67	244.0	COG0436@1|root,arCOG01131@2157|Archaea,2XVXM@28890|Euryarchaeota,243JD@183968|Thermococci	183968|Thermococci	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMS1_k127_1126226_2	868131.MSWAN_1046	1.375e-62	222.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,23NZ0@183925|Methanobacteria	183925|Methanobacteria	S	metal-binding-domain 4Fe-4S-binding-domain containing ABC transporter	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMS1_k127_1126226_3	387631.Asulf_02191	8.376e-37	147.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,246P3@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS1_k127_1126226_0	415426.Hbut_0783	2.856e-103	340.0	COG1156@1|root,arCOG00865@2157|Archaea,2XPKW@28889|Crenarchaeota	28889|Crenarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_1141933_39	304371.MCP_2297	8.943e-07	55.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2N9X3@224756|Methanomicrobia	224756|Methanomicrobia	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
MMS1_k127_1141933_24	573064.Mefer_1462	7.442e-35	141.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,23QQD@183939|Methanococci	183939|Methanococci	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
MMS1_k127_1141933_40	1227276.HMPREF9148_01196	1.83e-06	58.0	COG1266@1|root,COG1266@2|Bacteria,4NMMK@976|Bacteroidetes	976|Bacteroidetes	S	CAAX amino terminal protease family	sagE	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
MMS1_k127_1141933_38	673860.AciM339_0485	2.775e-07	53.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,3F2VM@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMS1_k127_1141933_23	579137.Metvu_0875	9.418e-36	140.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,23R14@183939|Methanococci	183939|Methanococci	J	Functions by promoting the formation of the first peptide bond	eif5a	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMS1_k127_1141933_5	573063.Metin_0058	2.042e-99	335.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS1_k127_1141933_4	573063.Metin_0058	2.865e-100	337.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,23QJU@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS1_k127_1141933_34	742817.HMPREF9449_02107	1.532e-15	88.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM
MMS1_k127_1141933_1	608538.HTH_1466	3.403e-159	521.0	COG1793@1|root,COG1793@2|Bacteria,2G4Q6@200783|Aquificae	200783|Aquificae	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMS1_k127_1141933_25	1131266.ARWQ01000014_gene97	3.456e-32	127.0	arCOG06790@1|root,arCOG06790@2157|Archaea,41T7J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
MMS1_k127_1141933_15	634497.HAH_4247	1.695e-56	212.0	COG3177@1|root,arCOG03110@2157|Archaea,2XUN8@28890|Euryarchaeota,23THX@183963|Halobacteria	183963|Halobacteria	K	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N
MMS1_k127_1141933_12	710686.Mycsm_06185	6.592e-63	249.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,23EVE@1762|Mycobacteriaceae	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS1_k127_1141933_11	439481.Aboo_1161	3.923e-64	228.0	COG1208@1|root,arCOG00666@2157|Archaea,2XUA6@28890|Euryarchaeota,3F2XH@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	Nucleotidyl transferase	graD	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
MMS1_k127_1141933_32	742765.HMPREF9457_00322	6.095e-21	102.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,27UYR@189330|Dorea	186801|Clostridia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
MMS1_k127_1141933_13	742817.HMPREF9449_02799	4.919e-60	218.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,2FSS3@200643|Bacteroidia,22XZG@171551|Porphyromonadaceae	976|Bacteroidetes	E	Arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS1_k127_1141933_29	926550.CLDAP_20380	1.447e-24	107.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi	200795|Chloroflexi	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMS1_k127_1141933_43	420247.Msm_0199	7.388e-05	50.0	COG1412@1|root,arCOG04312@2157|Archaea,2XZ0Z@28890|Euryarchaeota,23PRW@183925|Methanobacteria	183925|Methanobacteria	V	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
MMS1_k127_1141933_19	647113.Metok_0226	5.179e-46	173.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,23Q1F@183939|Methanococci	183939|Methanococci	K	RNA binding S1 domain protein	-	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
MMS1_k127_1141933_36	224325.AF_1116	4.577e-11	64.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,246H5@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
MMS1_k127_1141933_22	1163730.FFONT_1027	5.504e-39	154.0	COG1047@1|root,arCOG00980@2157|Archaea,2XQ07@28889|Crenarchaeota	28889|Crenarchaeota	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
MMS1_k127_1141933_3	1131266.ARWQ01000001_gene1192	1.898e-119	404.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMS1_k127_1141933_18	439235.Dalk_1960	1.287e-51	190.0	COG2220@1|root,COG2220@2|Bacteria,1QB9E@1224|Proteobacteria,42N7W@68525|delta/epsilon subdivisions,2WNMC@28221|Deltaproteobacteria,2MKW3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
MMS1_k127_1141933_20	593117.TGAM_0904	5.134e-40	159.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,242SR@183968|Thermococci	183968|Thermococci	J	Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMS1_k127_1141933_45	926562.Oweho_2253	0.0008155	51.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Gram_pos_anchor
MMS1_k127_1141933_10	700598.Niako_0694	2.754e-68	251.0	COG0457@1|root,COG1222@1|root,COG0457@2|Bacteria,COG1222@2|Bacteria,4NGR6@976|Bacteroidetes,1IWHT@117747|Sphingobacteriia	976|Bacteroidetes	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA,TPR_19,TPR_8
MMS1_k127_1141933_30	555079.Toce_0936	6.215e-23	103.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia,42H5V@68295|Thermoanaerobacterales	186801|Clostridia	L	Reverse transcriptase-like	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
MMS1_k127_1141933_41	351160.RRC93	1.025e-05	51.0	arCOG01059@1|root,arCOG01059@2157|Archaea,2Y0H1@28890|Euryarchaeota,2N9Y0@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1141933_42	351160.LRC552	1.065e-05	58.0	COG4745@1|root,arCOG00562@2157|Archaea	2157|Archaea	O	membrane-bound mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS1_k127_1141933_16	634498.mru_0522	9.261e-56	212.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,23NT6@183925|Methanobacteria	183925|Methanobacteria	U	secretion system protein	gspE	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS1_k127_1141933_0	1056495.Calag_0990	1.23e-217	689.0	COG1053@1|root,arCOG00571@2157|Archaea,2XPP3@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS1_k127_1141933_9	1056495.Calag_0993	1.409e-73	260.0	COG0479@1|root,arCOG00962@2157|Archaea,2XQDR@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
MMS1_k127_1141933_2	1121091.AUMP01000002_gene2230	2.937e-136	447.0	COG0114@1|root,COG0114@2|Bacteria,1UHPH@1239|Firmicutes,4HA6P@91061|Bacilli	91061|Bacilli	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS1_k127_1141933_8	593117.TGAM_1638	4.946e-78	276.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,242QW@183968|Thermococci	183968|Thermococci	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMS1_k127_1141933_44	215358.XP_010744647.1	0.0003329	49.0	COG1730@1|root,KOG3048@2759|Eukaryota,3A49T@33154|Opisthokonta,3BPBF@33208|Metazoa,3D6IC@33213|Bilateria,48903@7711|Chordata,496IG@7742|Vertebrata,4A2UP@7898|Actinopterygii	33208|Metazoa	O	prefoldin	PFDN5	GO:0001654,GO:0003674,GO:0003712,GO:0003714,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0007275,GO:0007423,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0016272,GO:0019219,GO:0019222,GO:0023051,GO:0023057,GO:0030111,GO:0030178,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032501,GO:0032502,GO:0032991,GO:0043010,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048513,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060041,GO:0060255,GO:0060828,GO:0065007,GO:0080090,GO:0090090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMS1_k127_1141933_26	673860.AciM339_0029	4.25e-32	133.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,3F2QF@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMS1_k127_1141933_6	555079.Toce_0364	1.371e-82	282.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42EWQ@68295|Thermoanaerobacterales	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	mtaP	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS1_k127_1141933_33	985053.VMUT_1610	5.832e-16	90.0	COG1361@1|root,arCOG02089@2157|Archaea,2XRI8@28889|Crenarchaeota	28889|Crenarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1141933_35	1437425.CSEC_2423	6.666e-14	83.0	COG0842@1|root,COG0842@2|Bacteria,2JGI3@204428|Chlamydiae	204428|Chlamydiae	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS1_k127_1141933_7	693661.Arcve_1732	3.387e-78	272.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota	28890|Euryarchaeota	E	COG1131 ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS1_k127_1141933_28	69014.TK1732	2.179e-26	120.0	COG0463@1|root,arCOG00894@2157|Archaea,2XUJ6@28890|Euryarchaeota,242XZ@183968|Thermococci	183968|Thermococci	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_1141933_27	573063.Metin_1389	2.893e-31	129.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,23QNQ@183939|Methanococci	183939|Methanococci	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS1_k127_1141933_17	926562.Oweho_3543	9.822e-55	197.0	COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia,2PAX6@246874|Cryomorphaceae	976|Bacteroidetes	I	NUDIX domain	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
MMS1_k127_1141933_14	877455.Metbo_0198	2.73e-57	214.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,23NUP@183925|Methanobacteria	183925|Methanobacteria	J	Diphthamide	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMS1_k127_1141933_31	263820.PTO0113	4.236e-22	103.0	COG0500@1|root,arCOG01793@2157|Archaea,2Y1JK@28890|Euryarchaeota,242DW@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS1_k127_1141933_21	1122611.KB903967_gene5168	1.021e-39	152.0	COG0590@1|root,COG0590@2|Bacteria,2INAI@201174|Actinobacteria,4EQ39@85012|Streptosporangiales	201174|Actinobacteria	FJ	MafB19-like deaminase	-	-	-	-	-	-	-	-	-	-	-	-	dCMP_cyt_deam_1
MMS1_k127_138107_11	456442.Mboo_0667	1.257e-21	101.0	COG1047@1|root,arCOG00981@2157|Archaea,2XXFW@28890|Euryarchaeota,2NAZY@224756|Methanomicrobia	224756|Methanomicrobia	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
MMS1_k127_138107_15	1519464.HY22_07990	3.186e-09	68.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS19835	UbiA
MMS1_k127_138107_6	420246.GTNG_2145	1.422e-35	148.0	COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,4HAR9@91061|Bacilli,1WEYV@129337|Geobacillus	91061|Bacilli	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS1_k127_138107_7	376686.Fjoh_1467	2.879e-29	126.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,1HX52@117743|Flavobacteriia,2NSMT@237|Flavobacterium	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS1_k127_138107_4	387631.Asulf_00693	1.167e-59	217.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,245Q7@183980|Archaeoglobi	183980|Archaeoglobi	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMS1_k127_138107_9	529709.PYCH_07400	3.127e-23	112.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS1_k127_138107_2	572546.Arcpr_0988	6.112e-86	291.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota	28890|Euryarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	pcrB	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMS1_k127_138107_10	13689.BV96_02863	6.199e-23	110.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,2K23Q@204457|Sphingomonadales	204457|Sphingomonadales	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
MMS1_k127_138107_19	1121936.AUHI01000011_gene1041	8.109e-05	53.0	COG0506@1|root,COG0506@2|Bacteria,1TQV3@1239|Firmicutes,4HAC1@91061|Bacilli	91061|Bacilli	E	Proline dehydrogenase	fadM	GO:0000166,GO:0003674,GO:0003824,GO:0004657,GO:0005488,GO:0006082,GO:0006520,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
MMS1_k127_138107_5	426368.MmarC7_1638	1.141e-46	184.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,23Q6G@183939|Methanococci	183939|Methanococci	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMS1_k127_138107_8	656024.FsymDg_4426	4.683e-26	110.0	COG1162@1|root,COG1162@2|Bacteria,2GU32@201174|Actinobacteria,4EWKA@85013|Frankiales	201174|Actinobacteria	S	RNHCP domain	-	-	-	-	-	-	-	-	-	-	-	-	RNHCP
MMS1_k127_138107_17	273063.STK_08870	3.43e-07	64.0	arCOG07351@1|root,arCOG07351@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_138107_12	330779.Saci_1051	2.138e-21	109.0	COG1215@1|root,arCOG01391@2157|Archaea,2XQ2X@28889|Crenarchaeota	28889|Crenarchaeota	M	Glycosyl transferase family 21	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Glyco_tranf_2_3,Glyco_trans_2_3
MMS1_k127_138107_16	1230457.C476_13278	1.693e-07	59.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,23WV5@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
MMS1_k127_138107_13	273063.STK_21890	4.607e-19	91.0	COG1308@1|root,arCOG04061@2157|Archaea,2XQTU@28889|Crenarchaeota	28889|Crenarchaeota	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
MMS1_k127_138107_18	1132509.C447_06351	1.957e-06	55.0	COG1591@1|root,arCOG00919@2157|Archaea,2XTHF@28890|Euryarchaeota,23TR3@183963|Halobacteria	183963|Halobacteria	L	A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products	hjc	-	3.1.22.4	ko:K03552	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Hjc
MMS1_k127_138107_1	397948.Cmaq_0169	1.887e-106	362.0	COG0358@1|root,arCOG04281@2157|Archaea,2XPXM@28889|Crenarchaeota	28889|Crenarchaeota	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMS1_k127_138107_0	565033.GACE_1190	2.018e-197	633.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,246NI@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
MMS1_k127_138107_3	330779.Saci_0282	6.62e-78	269.0	COG0730@1|root,arCOG02050@2157|Archaea,2XPPX@28889|Crenarchaeota	28889|Crenarchaeota	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	DUF1634,TauE
MMS1_k127_138107_14	1056495.Calag_0018	1.701e-13	75.0	COG4272@1|root,arCOG05396@2157|Archaea,2XS2W@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF1634)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
MMS1_k127_145406_16	868131.MSWAN_1046	2.58e-62	221.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,23NZ0@183925|Methanobacteria	183925|Methanobacteria	S	metal-binding-domain 4Fe-4S-binding-domain containing ABC transporter	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMS1_k127_145406_23	387631.Asulf_02191	2.521e-35	143.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,246P3@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS1_k127_145406_4	644281.MFS40622_0006	1.956e-188	600.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,23Q5U@183939|Methanococci	183939|Methanococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS1_k127_145406_1	1408322.JHYK01000009_gene2307	5.124e-215	682.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,27IS3@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS1_k127_145406_39	439481.Aboo_1263	2.573e-13	75.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y1TB@28890|Euryarchaeota,3F3EN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMS1_k127_145406_33	565033.GACE_1733	8.676e-22	108.0	COG1527@1|root,arCOG02459@2157|Archaea,2XTK5@28890|Euryarchaeota,24612@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMS1_k127_145406_38	263820.PTO0494	1.593e-14	75.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y1B9@28890|Euryarchaeota,242DV@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS1_k127_145406_19	273075.Ta0008	6.02e-52	205.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,241UP@183967|Thermoplasmata	183967|Thermoplasmata	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS1_k127_145406_36	1123405.AUMM01000016_gene2486	3.115e-19	99.0	COG2933@1|root,COG2933@2|Bacteria,1UZA9@1239|Firmicutes,4HDIN@91061|Bacilli	91061|Bacilli	J	Sam-dependent methyltransferase	ygdE	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMS1_k127_145406_51	644281.MFS40622_0104	4.319e-05	48.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,23R9F@183939|Methanococci	183939|Methanococci	L	PFAM Transcription factor CBF NF-Y	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
MMS1_k127_145406_17	1321814.HMPREF9089_01160	3.072e-59	220.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,25UQG@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
MMS1_k127_145406_25	1894.JOER01000051_gene5426	5.191e-34	153.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Lactonase,TIG
MMS1_k127_145406_32	1123073.KB899241_gene1867	3.774e-22	114.0	COG3391@1|root,COG3391@2|Bacteria,1R7H9@1224|Proteobacteria,1SGRP@1236|Gammaproteobacteria,1X57E@135614|Xanthomonadales	135614|Xanthomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS1_k127_145406_46	272557.APE_2379a	3.43e-07	53.0	COG2075@1|root,arCOG01950@2157|Archaea,2XREK@28889|Crenarchaeota	28889|Crenarchaeota	J	Binds to the 23S rRNA	rpl24e	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMS1_k127_145406_40	523850.TON_0953	5.886e-13	72.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,244JE@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMS1_k127_145406_27	195522.BD01_0617	4.333e-33	135.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2444W@183968|Thermococci	183968|Thermococci	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMS1_k127_145406_0	224719.Abm4_0357	4.947e-242	767.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,23NSP@183925|Methanobacteria	183925|Methanobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_145406_20	529709.PYCH_03950	4.007e-48	181.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,242SU@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMS1_k127_145406_21	70601.3257969	1.446e-42	160.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,243D7@183968|Thermococci	183968|Thermococci	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMS1_k127_145406_35	456320.Mvol_1025	6.485e-20	93.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,23R1G@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
MMS1_k127_145406_7	537007.BLAHAN_04834	6.626e-123	407.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3XYME@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score 8.87	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
MMS1_k127_145406_9	877455.Metbo_2336	4.747e-107	357.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,23NWZ@183925|Methanobacteria	183925|Methanobacteria	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS1_k127_145406_10	572546.Arcpr_0357	1.857e-106	353.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2461M@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS1_k127_145406_29	768679.TTX_0012	2.052e-31	125.0	COG0051@1|root,arCOG01758@2157|Archaea,2XQTY@28889|Crenarchaeota	28889|Crenarchaeota	J	Involved in the binding of tRNA to the ribosomes	rps10	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMS1_k127_145406_5	693661.Arcve_1067	7.846e-181	574.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,246VQ@183980|Archaeoglobi	183980|Archaeoglobi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMS1_k127_145406_48	1280685.AUKC01000052_gene1351	4.926e-07	57.0	28V22@1|root,2ZH5I@2|Bacteria,1UR6V@1239|Firmicutes,2590N@186801|Clostridia,4BZDJ@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_145406_28	339860.Msp_1154	4.893e-32	134.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,23P2G@183925|Methanobacteria	183925|Methanobacteria	S	PFAM Peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_145406_2	374847.Kcr_0231	8.706e-210	684.0	COG0495@1|root,arCOG00809@2157|Archaea	2157|Archaea	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMS1_k127_145406_26	767817.Desgi_1547	5.655e-34	145.0	COG0438@1|root,COG0438@2|Bacteria,1UYSU@1239|Firmicutes	1239|Firmicutes	M	PFAM Glycosyl transferase, group 1	-	-	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_145406_12	69014.TK0549	5.599e-84	300.0	COG2192@1|root,arCOG01188@2157|Archaea,2XVCE@28890|Euryarchaeota,242ZR@183968|Thermococci	183968|Thermococci	O	carbamoyl transferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
MMS1_k127_145406_14	1499967.BAYZ01000090_gene4943	5.989e-76	267.0	COG0535@1|root,COG0535@2|Bacteria,2NPKA@2323|unclassified Bacteria	2|Bacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
MMS1_k127_145406_44	436229.JOEH01000005_gene2967	8.287e-09	70.0	COG2755@1|root,COG3209@1|root,COG4372@1|root,COG2755@2|Bacteria,COG3209@2|Bacteria,COG4372@2|Bacteria,2GMBB@201174|Actinobacteria,2NGBE@228398|Streptacidiphilus	201174|Actinobacteria	M	Laminin G domain	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,PT-HINT,RHS_repeat,SCP1201-deam
MMS1_k127_145406_49	714943.Mucpa_3747	5.179e-06	60.0	COG4733@1|root,COG4733@2|Bacteria,4NTXR@976|Bacteroidetes,1IZ2D@117747|Sphingobacteriia	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3
MMS1_k127_145406_47	938709.AUSH02000051_gene305	4.164e-07	64.0	COG1361@1|root,COG2911@1|root,COG4886@1|root,COG1361@2|Bacteria,COG2911@2|Bacteria,COG4886@2|Bacteria,4NJQ1@976|Bacteroidetes	976|Bacteroidetes	O	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,CHU_C,Laminin_G_3
MMS1_k127_145406_45	938709.AUSH02000045_gene357	1.823e-07	65.0	COG1361@1|root,COG1506@1|root,COG2304@1|root,COG2374@1|root,COG3209@1|root,COG3391@1|root,COG4886@1|root,COG5184@1|root,COG1361@2|Bacteria,COG1506@2|Bacteria,COG2304@2|Bacteria,COG2374@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	rapB1	-	1.14.17.3,3.2.1.8	ko:K00504,ko:K01181,ko:K06889,ko:K07004,ko:K12548	-	-	-	-	ko00000,ko01000	-	-	-	CHU_C,DUF11
MMS1_k127_145406_34	714943.Mucpa_3747	5.478e-21	110.0	COG4733@1|root,COG4733@2|Bacteria,4NTXR@976|Bacteroidetes,1IZ2D@117747|Sphingobacteriia	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3
MMS1_k127_145406_37	1163730.FFONT_0232	3.414e-15	79.0	COG4818@1|root,arCOG04344@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_145406_11	926692.AZYG01000007_gene1350	1.214e-102	348.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,3WB5Z@53433|Halanaerobiales	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
MMS1_k127_145406_8	580332.Slit_2088	1.007e-107	357.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,44V90@713636|Nitrosomonadales	28216|Betaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
MMS1_k127_145406_6	1121382.JQKG01000001_gene2289	5.322e-148	480.0	COG0821@1|root,COG0821@2|Bacteria,1WJ94@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
MMS1_k127_145406_24	1322246.BN4_11754	1.017e-34	144.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,42MJI@68525|delta/epsilon subdivisions,2WJQP@28221|Deltaproteobacteria,2M88E@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM 6-phosphogluconate dehydrogenase NAD-binding	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2620	6PGD,NAD_binding_2
MMS1_k127_145406_43	1006006.Mcup_0139	3.113e-09	69.0	COG0432@1|root,arCOG04214@2157|Archaea,2XQYP@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
MMS1_k127_145406_22	439481.Aboo_0717	2.281e-35	150.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y719@28890|Euryarchaeota,3F34W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_145406_30	1123386.AUIW01000001_gene324	2.231e-30	124.0	COG1694@1|root,COG1694@2|Bacteria,1WK7E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
MMS1_k127_145406_3	342949.PNA2_1084	4.347e-208	666.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,245CQ@183968|Thermococci	183968|Thermococci	O	Belongs to the peptidase S16 family	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
MMS1_k127_145406_13	404589.Anae109_2770	2.366e-83	290.0	COG1697@1|root,COG1697@2|Bacteria,1NBFJ@1224|Proteobacteria,4314R@68525|delta/epsilon subdivisions,2WWNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
MMS1_k127_145406_18	515635.Dtur_0683	4.773e-53	194.0	COG0177@1|root,COG0177@2|Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
MMS1_k127_145406_31	1227454.C446_13059	4.26e-24	117.0	COG3379@1|root,arCOG01377@2157|Archaea,2XUWW@28890|Euryarchaeota,23RZ5@183963|Halobacteria	183963|Halobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
MMS1_k127_145406_42	868131.MSWAN_1524	3.547e-12	78.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUSA@28890|Euryarchaeota,23P0M@183925|Methanobacteria	183925|Methanobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_145406_52	709032.Sulku_1116	0.0003573	48.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
MMS1_k127_145406_41	444157.Tneu_1766	6.346e-13	75.0	COG1430@1|root,arCOG03115@2157|Archaea	2157|Archaea	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
MMS1_k127_145406_15	273116.14324437	3.708e-74	252.0	COG0450@1|root,arCOG00312@2157|Archaea,2XYCY@28890|Euryarchaeota,242AV@183967|Thermoplasmata	183967|Thermoplasmata	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
MMS1_k127_145406_50	399550.Smar_1027	8.741e-06	49.0	COG1588@1|root,arCOG00784@2157|Archaea,2XR9D@28889|Crenarchaeota	28889|Crenarchaeota	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp1	-	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
MMS1_k127_1524865_3	358681.BBR47_29370	7.984e-24	113.0	COG0726@1|root,COG0726@2|Bacteria,1VVZW@1239|Firmicutes,4HW15@91061|Bacilli	2|Bacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1,tRNA-Thr_ED
MMS1_k127_1524865_0	903818.KI912268_gene1215	4.763e-63	233.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	nodC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006082,GO:0006807,GO:0007155,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016757,GO:0016758,GO:0019752,GO:0022607,GO:0022610,GO:0030198,GO:0030203,GO:0030212,GO:0030213,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0042710,GO:0043062,GO:0043170,GO:0043436,GO:0044010,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0045226,GO:0046379,GO:0046394,GO:0050501,GO:0051704,GO:0071704,GO:0071840,GO:0071944,GO:0085029,GO:0090605,GO:0090609,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510	2.4.1.212	ko:K00752,ko:K14666	-	M00664	-	-	ko00000,ko00002,ko01000,ko01003,ko02000	4.D.1.1.10,4.D.1.1.4,4.D.1.1.5	GT2	-	Chitin_synth_2,Glyco_tranf_2_3,Glycos_transf_2,PilZ
MMS1_k127_1524865_7	1333998.M2A_0843	0.0004518	52.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,4BQXA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	MA20_31615	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS1_k127_1524865_1	399549.Msed_0871	1.097e-37	144.0	COG3189@1|root,arCOG06027@2157|Archaea,2XS3W@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
MMS1_k127_1524865_6	660470.Theba_2355	1.499e-06	62.0	COG3266@1|root,COG4870@1|root,COG3266@2|Bacteria,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.1.26.12,3.2.1.8	ko:K01181,ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	DUF349,Peptidase_C1
MMS1_k127_1524865_4	1006006.Mcup_1989	3.563e-17	88.0	COG1890@1|root,arCOG04186@2157|Archaea,2XPNX@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
MMS1_k127_1524865_2	1343739.PAP_03805	1.508e-32	132.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,243T7@183968|Thermococci	183968|Thermococci	J	structural constituent of ribosome	rps15	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMS1_k127_1524865_5	1453505.JASY01000003_gene1934	2.844e-12	81.0	COG3266@1|root,COG3866@1|root,COG3266@2|Bacteria,COG3866@2|Bacteria,4PN6U@976|Bacteroidetes,1IKRR@117743|Flavobacteriia,2P0VU@237|Flavobacterium	976|Bacteroidetes	G	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,DUF4990
MMS1_k127_1536550_25	985053.VMUT_0965	6.421e-15	78.0	COG1727@1|root,arCOG00780@2157|Archaea,2XQV1@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18,Ribosomal_L27A
MMS1_k127_1536550_21	374847.Kcr_1587	2.68e-24	110.0	COG0102@1|root,arCOG04242@2157|Archaea	2157|Archaea	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS1_k127_1536550_19	1071085.KK033115_gene2410	2.138e-26	115.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,23VBN@183963|Halobacteria	183963|Halobacteria	J	Belongs to the universal ribosomal protein uS9 family	rps9p	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS1_k127_1536550_20	1202768.JROF01000009_gene585	2.551e-24	103.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,23WQQ@183963|Halobacteria	183963|Halobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMS1_k127_1536550_14	439481.Aboo_1302	1.453e-64	228.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,3F2J8@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS1_k127_1536550_2	401526.TcarDRAFT_1926	3.288e-151	492.0	COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,4H2FJ@909932|Negativicutes	909932|Negativicutes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS1_k127_1536550_3	868131.MSWAN_1861	9.491e-148	492.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,23NN9@183925|Methanobacteria	183925|Methanobacteria	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
MMS1_k127_1536550_33	273075.Ta0062	0.0003659	52.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2427H@183967|Thermoplasmata	183967|Thermoplasmata	S	Presenilin, signal peptide peptidase, family	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMS1_k127_1536550_28	926550.CLDAP_01000	1.783e-11	76.0	COG3572@1|root,COG3572@2|Bacteria	2|Bacteria	H	ergothioneine biosynthetic process	-	-	6.3.2.2	ko:K01919,ko:K06048	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
MMS1_k127_1536550_16	273075.Ta1097	3.385e-48	179.0	COG3374@1|root,arCOG04349@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF981)	-	-	-	ko:K08980	-	-	-	-	ko00000	-	-	-	DUF981
MMS1_k127_1536550_6	439481.Aboo_0917	1.694e-104	354.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,3F2HD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS1_k127_1536550_9	386456.JQKN01000002_gene2869	9.336e-82	285.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,23NP9@183925|Methanobacteria	183925|Methanobacteria	S	C-terminal region of MMR_HSR1 domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
MMS1_k127_1536550_5	339860.Msp_0124	3.043e-108	367.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,23NUS@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMS1_k127_1536550_30	641143.HMPREF9331_02419	1.973e-06	58.0	COG1621@1|root,COG2133@1|root,COG1621@2|Bacteria,COG2133@2|Bacteria,4NEYI@976|Bacteroidetes,1HYGZ@117743|Flavobacteriia,1EQQY@1016|Capnocytophaga	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 32 family	-	-	3.2.1.80	ko:K03332	ko00051,map00051	-	R00879	-	ko00000,ko00001,ko01000	-	-	-	DUF4980,Glyco_hydro_32C,Glyco_hydro_32N
MMS1_k127_1536550_32	604354.TSIB_1817	3.781e-06	49.0	arCOG06624@1|root,arCOG06624@2157|Archaea,2Y56V@28890|Euryarchaeota,244UF@183968|Thermococci	183968|Thermococci	-	-	rpl41e	-	-	ko:K02928	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
MMS1_k127_1536550_23	4896.SPAP27G11.07c.1	5.948e-18	93.0	COG3642@1|root,KOG3087@2759|Eukaryota,38E5H@33154|Opisthokonta,3NVEV@4751|Fungi,3QMMM@4890|Ascomycota,3MDY3@451866|Taphrinomycotina	4751|Fungi	H	BUD32 protein kinase	BUD32	GO:0000003,GO:0000166,GO:0000278,GO:0000281,GO:0000282,GO:0000408,GO:0000722,GO:0000723,GO:0000910,GO:0002949,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006312,GO:0006355,GO:0006357,GO:0006396,GO:0006399,GO:0006400,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007049,GO:0007163,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009653,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0016301,GO:0016310,GO:0016462,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0019538,GO:0019954,GO:0022402,GO:0030010,GO:0030154,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032200,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043934,GO:0043936,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051276,GO:0051301,GO:0060249,GO:0060255,GO:0061640,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902680,GO:1903047,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	APH,Kdo,Pkinase
MMS1_k127_1536550_12	673860.AciM339_0381	8.19e-80	276.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,3F2H7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	LT	Protein kinase domain	kae1	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234,2.7.11.1	ko:K08851,ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,Pkinase,RIO1
MMS1_k127_1536550_7	351160.RRC219	3.144e-102	345.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
MMS1_k127_1536550_27	1288079.AUKN01000019_gene2766	1.478e-12	73.0	2E6DR@1|root,3311A@2|Bacteria,2IKTW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1536550_31	1131266.ARWQ01000001_gene1164	3.151e-06	52.0	COG2012@1|root,arCOG04258@2157|Archaea,41SU8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMS1_k127_1536550_4	573064.Mefer_1262	5.327e-133	440.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,23Q3N@183939|Methanococci	183939|Methanococci	K	Belongs to the RNA polymerase beta chain family	rpoB2	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
MMS1_k127_1536550_1	1042877.GQS_03950	1.404e-196	630.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,24327@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS1_k127_1536550_0	1183377.Py04_1439	5.913e-247	788.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,242YY@183968|Thermococci	183968|Thermococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS1_k127_1536550_11	644281.MFS40622_1660	3.998e-81	282.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,23Q5X@183939|Methanococci	183939|Methanococci	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
MMS1_k127_1536550_24	386456.JQKN01000002_gene2402	4.548e-17	82.0	COG1958@1|root,arCOG00998@2157|Archaea,2XZTF@28890|Euryarchaeota,23P7B@183925|Methanobacteria	183925|Methanobacteria	K	Belongs to the snRNP Sm proteins family	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS1_k127_1536550_22	273116.14324887	2.882e-22	101.0	COG0393@1|root,arCOG02287@2157|Archaea,2XYRF@28890|Euryarchaeota,2429W@183967|Thermoplasmata	183967|Thermoplasmata	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
MMS1_k127_1536550_17	1041930.Mtc_1209	3.236e-35	138.0	COG0393@1|root,arCOG02287@2157|Archaea,2XYRF@28890|Euryarchaeota,2NAUZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
MMS1_k127_1536550_15	273057.SSO1810	1.263e-49	193.0	COG0577@1|root,arCOG02312@2157|Archaea,2XQ0N@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_1536550_26	930945.SiRe_1329	4.036e-13	81.0	COG1361@1|root,arCOG02089@2157|Archaea	2157|Archaea	M	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1536550_13	484019.THA_432	2.366e-68	239.0	COG1136@1|root,COG1136@2|Bacteria,2GCNV@200918|Thermotogae	200918|Thermotogae	P	PFAM ABC transporter	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS1_k127_1536550_8	273075.Ta0228	1.907e-84	287.0	COG0412@1|root,arCOG01659@2157|Archaea,2Y6XB@28890|Euryarchaeota,2422E@183967|Thermoplasmata	183967|Thermoplasmata	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS1_k127_1536550_10	221288.JH992901_gene3104	2.412e-81	281.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,1JH5Z@1189|Stigonemataceae	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
MMS1_k127_1536550_18	1443122.Z958_01730	7.532e-29	120.0	COG1051@1|root,COG1051@2|Bacteria,1V5NQ@1239|Firmicutes,24PPQ@186801|Clostridia,36K3B@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_1536550_29	592028.GCWU000321_00517	2.064e-08	58.0	COG0125@1|root,COG0125@2|Bacteria,1V2D5@1239|Firmicutes,4H45J@909932|Negativicutes	909932|Negativicutes	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS1_k127_1760742_11	745718.JADT01000019_gene1519	2.084e-31	131.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
MMS1_k127_1760742_19	1278307.KB906982_gene3959	7.59e-11	73.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
MMS1_k127_1760742_21	467661.RKLH11_646	0.0001491	49.0	2DX1G@1|root,342Z1@2|Bacteria,1NYIP@1224|Proteobacteria,2USYV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1760742_4	374847.Kcr_1200	1.115e-121	404.0	COG0017@1|root,arCOG00406@2157|Archaea	2157|Archaea	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12,6.1.1.23	ko:K09759,ko:K22503	ko00970,map00970	M00359,M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS1_k127_1760742_9	273116.14324226	7.061e-45	169.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,241R4@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMS1_k127_1760742_12	36080.S2J0Q3	4.96e-31	131.0	COG0494@1|root,2S254@2759|Eukaryota,39ZYW@33154|Opisthokonta,3P53K@4751|Fungi,1GU9K@112252|Fungi incertae sedis	4751|Fungi	L	NUDIX domain	-	-	3.6.1.55,3.6.1.56	ko:K03574,ko:K17816	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
MMS1_k127_1760742_6	694427.Palpr_0601	5.118e-63	218.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia,22WQ9@171551|Porphyromonadaceae	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS1_k127_1760742_2	671065.MetMK1DRAFT_00005910	6.117e-136	449.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XQ4R@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS1_k127_1760742_7	1519464.HY22_08455	1.276e-53	194.0	COG0225@1|root,COG0225@2|Bacteria,1FE4X@1090|Chlorobi	1090|Chlorobi	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS1_k127_1760742_20	448385.sce0493	3.22e-06	57.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
MMS1_k127_1760742_10	1444712.BN1013_00717	2.246e-44	167.0	COG1986@1|root,COG1986@2|Bacteria	2|Bacteria	F	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
MMS1_k127_1760742_17	1455608.JDTH01000001_gene3009	2.667e-20	100.0	COG0455@1|root,arCOG00589@2157|Archaea,2XT20@28890|Euryarchaeota,23SDD@183963|Halobacteria	183963|Halobacteria	D	COG0455 ATPases involved in chromosome partitioning	-	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,ParA
MMS1_k127_1760742_15	1229909.NSED_09745	8.956e-25	119.0	COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Sodium hydrogen exchanger	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger
MMS1_k127_1760742_14	339860.Msp_1545	1.138e-25	114.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,23P23@183925|Methanobacteria	183925|Methanobacteria	Q	Lysine methyltransferase	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMS1_k127_1760742_3	1459636.NTE_02652	3.674e-130	427.0	COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS1_k127_1760742_5	1122602.ATXP01000004_gene1865	2.931e-73	254.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,1W7E7@1268|Micrococcaceae	201174|Actinobacteria	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
MMS1_k127_1760742_18	1122212.AULO01000006_gene1669	4.238e-17	94.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XINT@135619|Oceanospirillales	135619|Oceanospirillales	O	COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
MMS1_k127_1760742_0	436308.Nmar_0495	4.813e-188	598.0	COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
MMS1_k127_1760742_22	1293048.CBMB010000004_gene1658	0.0001851	48.0	COG1992@1|root,arCOG00021@2157|Archaea,2XTP7@28890|Euryarchaeota,23SNG@183963|Halobacteria	183963|Halobacteria	H	Transcriptional regulator	thiN2	-	-	ko:K22206	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,ThiP_synth
MMS1_k127_1760742_13	1041930.Mtc_1646	4.932e-27	119.0	COG1018@1|root,arCOG02200@2157|Archaea,2XVD3@28890|Euryarchaeota,2N9JH@224756|Methanomicrobia	224756|Methanomicrobia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
MMS1_k127_1760742_1	1229909.NSED_05490	4.059e-175	578.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS1_k127_1760742_8	743525.TSC_c17890	1.021e-48	178.0	COG1225@1|root,COG1225@2|Bacteria,1WI9E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS1_k127_1760742_16	572544.Ilyop_0960	8.577e-22	100.0	COG0494@1|root,COG0494@2|Bacteria,378TQ@32066|Fusobacteria	32066|Fusobacteria	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
MMS1_k127_1916119_4	68223.JNZY01000025_gene6261	8.815e-28	133.0	COG2931@1|root,COG3055@1|root,COG2931@2|Bacteria,COG3055@2|Bacteria,2GTWD@201174|Actinobacteria	201174|Actinobacteria	Q	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1916119_5	146922.JOFU01000073_gene7911	4.822e-27	130.0	COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria	201174|Actinobacteria	KLT	PQQ enzyme repeat	-	-	1.1.2.6,2.7.11.1	ko:K05889,ko:K12132	-	-	R03136	-	ko00000,ko01000,ko01001	-	-	-	PQQ,PQQ_2,PQQ_3,Pkinase
MMS1_k127_1916119_1	1459636.NTE_03097	1.859e-58	218.0	arCOG03664@1|root,arCOG03664@2157|Archaea	2157|Archaea	S	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3
MMS1_k127_1916119_2	868131.MSWAN_0004	1.243e-55	202.0	COG1704@1|root,arCOG04574@2157|Archaea,2XXB9@28890|Euryarchaeota,23PHV@183925|Methanobacteria	183925|Methanobacteria	S	PFAM LemA	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
MMS1_k127_1916119_0	269799.Gmet_1156	3.734e-60	218.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,43T22@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
MMS1_k127_1916119_7	647113.Metok_1431	2.335e-19	97.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,23QRU@183939|Methanococci	183939|Methanococci	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS1_k127_1916119_6	593750.Metfor_2881	1.984e-19	91.0	arCOG12677@1|root,arCOG12677@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_1916119_8	745411.B3C1_00435	8.532e-19	95.0	COG0421@1|root,COG0421@2|Bacteria,1N1PJ@1224|Proteobacteria,1SY8T@1236|Gammaproteobacteria,1JA5K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
MMS1_k127_1916119_3	710686.Mycsm_04737	1.147e-50	204.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2366T@1762|Mycobacteriaceae	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Lactonase
MMS1_k127_193924_1	1459636.NTE_01283	5.67e-179	590.0	COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS1_k127_193924_6	118163.Ple7327_0843	4.054e-29	123.0	COG0494@1|root,COG0494@2|Bacteria,1G60V@1117|Cyanobacteria,3VMGD@52604|Pleurocapsales	1117|Cyanobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_193924_7	5865.XP_001608752.1	7.152e-17	91.0	KOG4760@1|root,KOG4760@2759|Eukaryota,3YANB@5794|Apicomplexa,3KBXF@422676|Aconoidasida,3Z3W1@5863|Piroplasmida	422676|Aconoidasida	S	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K17815	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exo5
MMS1_k127_193924_9	596319.STAWA0001_1439	3.129e-13	78.0	COG0546@1|root,COG0546@2|Bacteria,1V60J@1239|Firmicutes,4HI7Y@91061|Bacilli,4GZ0A@90964|Staphylococcaceae	1239|Firmicutes	S	HAD hydrolase, family IA, variant 1	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
MMS1_k127_193924_10	397948.Cmaq_1239	6.988e-11	67.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
MMS1_k127_193924_0	1048834.TC41_0926	3.634e-309	973.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4HB5N@91061|Bacilli,2793N@186823|Alicyclobacillaceae	91061|Bacilli	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043937,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0050789,GO:0050793,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS06730	Aconitase,Aconitase_C
MMS1_k127_193924_3	102125.Xen7305DRAFT_00052760	1.016e-108	367.0	COG0579@1|root,COG0579@2|Bacteria,1G4FU@1117|Cyanobacteria,3VITJ@52604|Pleurocapsales	1117|Cyanobacteria	C	Malate:quinone oxidoreductase (Mqo)	mqo	-	1.1.5.4	ko:K00116	ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00360,R00361,R01257	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Mqo
MMS1_k127_193924_5	1041930.Mtc_2021	8.811e-51	193.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2N96D@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS1_k127_193924_4	869210.Marky_1069	2.585e-106	357.0	COG0372@1|root,COG0372@2|Bacteria,1WI65@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS1_k127_193924_2	330779.Saci_2375	2.55e-150	484.0	COG0538@1|root,arCOG01164@2157|Archaea,2XPUT@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM isocitrate dehydrogenase, NADP-dependent	idh	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS1_k127_193924_12	1094980.Mpsy_2452	4.095e-08	58.0	COG2026@1|root,arCOG02414@2157|Archaea,2Y1DC@28890|Euryarchaeota	28890|Euryarchaeota	K	TIGRFAM addiction module toxin, RelE StbE family	-	-	-	ko:K19158	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ParE_toxin
MMS1_k127_193924_8	1033733.CAEK01000003_gene1188	3.05e-13	77.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,22HF7@1570339|Peptoniphilaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
MMS1_k127_193924_11	304371.MCP_0887	8.766e-11	72.0	arCOG04442@1|root,arCOG04442@2157|Archaea,2XTSV@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
MMS1_k127_202578_15	1151117.AJLF01000003_gene617	9.37e-07	60.0	arCOG03415@1|root,arCOG03415@2157|Archaea,2XY91@28890|Euryarchaeota,243PM@183968|Thermococci	183968|Thermococci	S	Protein of unknown function (DUF2666)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2666
MMS1_k127_202578_13	273116.14325711	2.269e-11	66.0	arCOG05337@1|root,arCOG05337@2157|Archaea,2Y4WJ@28890|Euryarchaeota,242BU@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_202578_17	572478.Vdis_2400	0.0001562	45.0	COG1552@1|root,arCOG04049@2157|Archaea,2XRHJ@28889|Crenarchaeota	28889|Crenarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMS1_k127_202578_7	536233.CLO_1693	4.292e-24	116.0	COG3316@1|root,COG3677@1|root,COG3316@2|Bacteria,COG3677@2|Bacteria,1UY3S@1239|Firmicutes,25G7P@186801|Clostridia,36U7K@31979|Clostridiaceae	1239|Firmicutes	L	hmm pf00665	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240,Zn_Tnp_IS1
MMS1_k127_202578_16	1125700.HMPREF9195_00405	1.035e-05	55.0	COG4741@1|root,COG4741@2|Bacteria,2J8ES@203691|Spirochaetes	203691|Spirochaetes	F	COGs COG4741 secreted endonuclease distantly related to Holliday junction resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Endonuc_Holl
MMS1_k127_202578_0	647113.Metok_0524	1.859e-261	823.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23QF3@183939|Methanococci	183939|Methanococci	O	Cell division protein 48, CDC48, domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
MMS1_k127_202578_9	573063.Metin_0130	1.258e-20	96.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,23R2F@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMS1_k127_202578_2	647113.Metok_0259	2.71e-114	380.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,23QPD@183939|Methanococci	183939|Methanococci	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
MMS1_k127_202578_10	591019.Shell_0985	8.504e-19	98.0	COG2404@1|root,arCOG00423@2157|Archaea,2XQ5M@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM DHHA1 domain	-	-	-	ko:K07097	-	-	-	-	ko00000	-	-	-	DHHA1
MMS1_k127_202578_8	673860.AciM339_1236	1.003e-22	106.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,3F2NS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	K homology RNA-binding domain	dim2	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
MMS1_k127_202578_1	70601.3257993	3.298e-130	434.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,242PK@183968|Thermococci	183968|Thermococci	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMS1_k127_202578_18	1265503.KB905161_gene3034	0.0008264	43.0	COG0348@1|root,COG1145@1|root,COG0348@2|Bacteria,COG1145@2|Bacteria,1N09Y@1224|Proteobacteria,1S4EB@1236|Gammaproteobacteria,2Q72C@267889|Colwelliaceae	1236|Gammaproteobacteria	C	4Fe-4S dicluster domain	napF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0044424,GO:0044464,GO:0050896	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_7,Fer4_9
MMS1_k127_202578_14	273063.STK_03200	8.88e-11	74.0	COG0433@1|root,arCOG00286@2157|Archaea,2XQKU@28889|Crenarchaeota	28889|Crenarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMS1_k127_202578_3	1343739.PAP_00410	1.463e-92	323.0	COG4962@1|root,arCOG01819@2157|Archaea,2Y8F5@28890|Euryarchaeota,242XB@183968|Thermococci	183968|Thermococci	U	type II secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Intein_splicing,LAGLIDADG_3,T2SSE
MMS1_k127_202578_5	693661.Arcve_1306	9.731e-46	181.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2463A@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMS1_k127_202578_4	1151117.AJLF01000001_gene1738	1.68e-54	202.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,242WN@183968|Thermococci	183968|Thermococci	J	Met-10+ like-protein	-	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS1_k127_202578_19	1265505.ATUG01000002_gene2770	0.0008573	46.0	COG4231@1|root,COG4231@2|Bacteria,1N6WI@1224|Proteobacteria,42V3I@68525|delta/epsilon subdivisions,2WRKA@28221|Deltaproteobacteria,2MKZT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_202578_11	573063.Metin_1010	1.637e-16	82.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,23R5H@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
MMS1_k127_202578_12	337075.U4LUU2	2.505e-16	89.0	COG0244@1|root,KOG0815@2759|Eukaryota,38BU8@33154|Opisthokonta,3NWY4@4751|Fungi,3QMME@4890|Ascomycota	4751|Fungi	J	Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl- transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome	RPP0	GO:0000027,GO:0002181,GO:0002182,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030684,GO:0030686,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02941	ko03010,map03010	M00177	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s,Ribosomal_L10
MMS1_k127_202578_6	246969.TAM4_949	1.781e-37	149.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,242ZJ@183968|Thermococci	183968|Thermococci	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMS1_k127_2129032_27	1123508.JH636443_gene5018	2.492e-17	87.0	COG3324@1|root,COG3324@2|Bacteria,2J3W8@203682|Planctomycetes	203682|Planctomycetes	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
MMS1_k127_2129032_31	931627.MycrhDRAFT_0974	2.763e-13	83.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,PMT_2
MMS1_k127_2129032_22	572478.Vdis_0837	4.908e-38	157.0	COG1215@1|root,arCOG01389@2157|Archaea,2XR9F@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.336	ko:K19003	ko00561,ko01100,map00561,map01100	-	R02689	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glyco_tranf_2_3
MMS1_k127_2129032_10	1131269.AQVV01000007_gene1068	3.242e-76	261.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	yagB	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
MMS1_k127_2129032_24	273063.STK_05500	9.964e-34	145.0	COG1524@1|root,arCOG01378@2157|Archaea,2XQRC@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
MMS1_k127_2129032_26	521011.Mpal_1797	3.002e-27	118.0	COG2020@1|root,arCOG03580@2157|Archaea,2XXQD@28890|Euryarchaeota	28890|Euryarchaeota	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
MMS1_k127_2129032_29	439481.Aboo_1149	7.313e-15	82.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,3F2MW@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	NMD3 family	nmd3	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMS1_k127_2129032_17	604354.TSIB_1800	8.286e-47	189.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,243BT@183968|Thermococci	183968|Thermococci	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS1_k127_2129032_25	1220534.B655_0962	5.736e-32	139.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,23NZ5@183925|Methanobacteria	183925|Methanobacteria	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS1_k127_2129032_5	243232.MJ_1332	1.845e-100	340.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,23Q3F@183939|Methanococci	183939|Methanococci	J	GTP-binding protein HSR1-related	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
MMS1_k127_2129032_14	1151119.KB895493_gene1475	2.78e-50	186.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_2129032_28	868131.MSWAN_1947	3.616e-16	90.0	COG2064@1|root,arCOG01811@2157|Archaea,2Y71N@28890|Euryarchaeota,23P0K@183925|Methanobacteria	183925|Methanobacteria	N	Type II secretion system	gspF2	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS1_k127_2129032_32	1183377.Py04_1104	1.193e-12	80.0	COG2064@1|root,arCOG01812@2157|Archaea,2Y671@28890|Euryarchaeota,242WY@183968|Thermococci	183968|Thermococci	N	Type II secretion system (T2SS), protein F	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS1_k127_2129032_15	1123368.AUIS01000003_gene1806	1.458e-49	183.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,LUD_dom,SnoaL_3,SnoaL_4
MMS1_k127_2129032_30	273057.SSO0687	1.491e-13	81.0	COG1361@1|root,arCOG02089@2157|Archaea,2XSSJ@28889|Crenarchaeota	28889|Crenarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2129032_12	273063.STK_09040	2.155e-53	205.0	COG0577@1|root,arCOG02312@2157|Archaea,2XQ0N@28889|Crenarchaeota	28889|Crenarchaeota	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS1_k127_2129032_9	1123405.AUMM01000004_gene701	1.729e-76	265.0	COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,4HA59@91061|Bacilli,26NC6@186821|Sporolactobacillaceae	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS1_k127_2129032_6	273068.TTE0549	6.196e-99	336.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,42EVW@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the thiolase family	thlA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS1_k127_2129032_19	591001.Acfer_0549	6.143e-46	175.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4H217@909932|Negativicutes	909932|Negativicutes	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMS1_k127_2129032_20	990073.ATHU01000001_gene1564	1.22e-44	168.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2YN9C@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
MMS1_k127_2129032_8	1210884.HG799467_gene13470	9.996e-77	272.0	COG1960@1|root,COG1960@2|Bacteria,2IXMD@203682|Planctomycetes	2|Bacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS1_k127_2129032_38	1006006.Mcup_1522	1.308e-06	57.0	COG3427@1|root,arCOG01927@2157|Archaea,2XRD9@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
MMS1_k127_2129032_0	273063.STK_21720	1.349e-226	717.0	COG0129@1|root,arCOG04045@2157|Archaea,2XPQI@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
MMS1_k127_2129032_3	273116.14324383	1.777e-149	483.0	COG4948@1|root,arCOG01168@2157|Archaea,2XTSG@28890|Euryarchaeota,24211@183967|Thermoplasmata	183967|Thermoplasmata	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0003674,GO:0003824,GO:0008869,GO:0016829,GO:0016835,GO:0016836,GO:0047929	4.2.1.140	ko:K05308	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00308,M00309,M00633	R01538,R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS1_k127_2129032_21	273116.14325490	4.066e-43	169.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,241UJ@183967|Thermoplasmata	183967|Thermoplasmata	E	lyase activity	-	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0008150,GO:0008152,GO:0008674,GO:0008675,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	4.1.2.51,4.3.3.7	ko:K01714,ko:K18127	ko00030,ko00052,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00052,map00261,map00300,map01100,map01110,map01120,map01130,map01200,map01230	M00016,M00309,M00525,M00526,M00527	R08570,R10147,R10616	RC00307,RC00435,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS1_k127_2129032_1	273075.Ta0809	2.303e-216	681.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,24237@183967|Thermoplasmata	183967|Thermoplasmata	C	NADP-dependent dehydrogenase of the nED (non- phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D- glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3- phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006081,GO:0006082,GO:0006090,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009255,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016620,GO:0016903,GO:0019637,GO:0019682,GO:0019752,GO:0022607,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0043796,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0061678,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901575	1.2.1.89	ko:K18128	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R10615	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS1_k127_2129032_7	351160.RCIX1128	3.343e-83	288.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.140,1.1.1.359,1.1.1.360	ko:K00068,ko:K18124,ko:K18125	ko00030,ko00051,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00051,map00052,map01100,map01110,map01130,map01200	-	R01096,R05607,R07147,R08544	RC00066,RC00085	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
MMS1_k127_2129032_11	690850.Desaf_2039	2.119e-59	212.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,42SY1@68525|delta/epsilon subdivisions,2WPQ7@28221|Deltaproteobacteria,2MCAN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
MMS1_k127_2129032_2	869213.JCM21142_72607	1.42e-169	550.0	COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,47MRU@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolases family 15	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
MMS1_k127_2129032_4	263820.PTO1483	8.91e-129	424.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
MMS1_k127_2129032_40	1552123.EP57_10195	3.355e-05	52.0	COG0454@1|root,COG0456@2|Bacteria,1VBQ6@1239|Firmicutes,4HM63@91061|Bacilli,26IVD@186820|Listeriaceae	91061|Bacilli	K	GNAT family	yhhY	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS1_k127_2129032_13	368407.Memar_0905	5.991e-51	183.0	arCOG03001@1|root,arCOG03001@2157|Archaea,2Y6YJ@28890|Euryarchaeota,2NATB@224756|Methanomicrobia	224756|Methanomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS1_k127_2129032_18	977880.RALTA_B2107	5.92e-46	175.0	COG1073@1|root,COG1073@2|Bacteria,1NXZW@1224|Proteobacteria,2VNFH@28216|Betaproteobacteria,1K2U8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterised protein family (UPF0227)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4,Peptidase_S9
MMS1_k127_2129032_16	1047013.AQSP01000120_gene965	5.338e-48	177.0	COG3476@1|root,COG3476@2|Bacteria,2NQ7D@2323|unclassified Bacteria	2|Bacteria	T	TspO/MBR family	tspO	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
MMS1_k127_2129032_33	111780.Sta7437_1007	7.246e-11	70.0	COG0494@1|root,COG0494@2|Bacteria,1G60V@1117|Cyanobacteria,3VMGD@52604|Pleurocapsales	1117|Cyanobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_2129032_36	596152.DesU5LDRAFT_2681	1.65e-08	59.0	2DN97@1|root,32W7A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2129032_34	1069080.KB913028_gene217	2.22e-10	62.0	2DREN@1|root,33BEG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2195751_0	1070319.CAGGBEG34_250010	3.152e-269	854.0	COG0286@1|root,COG0286@2|Bacteria,1MXPV@1224|Proteobacteria	1224|Proteobacteria	L	type I restriction-modification system, methyltransferase subunit	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N_2,Methylase_S,N6_Mtase
MMS1_k127_2195751_9	1151117.AJLF01000001_gene1000	4.567e-88	310.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,243CX@183968|Thermococci	183968|Thermococci	L	ERCC4 domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,Helicase_C
MMS1_k127_2195751_25	933801.Ahos_1018	4.504e-38	153.0	COG1226@1|root,arCOG01958@2157|Archaea	2157|Archaea	P	COG1226 Kef-type K transport systems	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
MMS1_k127_2195751_19	525909.Afer_0227	3.307e-49	186.0	arCOG03842@1|root,30WW9@2|Bacteria,2IDJ1@201174|Actinobacteria,4CNKU@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Domain of unknown function (DUF929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF929
MMS1_k127_2195751_36	1121017.AUFG01000017_gene2498	3.937e-18	89.0	COG4243@1|root,COG4243@2|Bacteria,2HGRN@201174|Actinobacteria,4FGUP@85021|Intrasporangiaceae	201174|Actinobacteria	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
MMS1_k127_2195751_31	419665.Maeo_0138	5.196e-29	124.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23QUW@183939|Methanococci	183939|Methanococci	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMS1_k127_2195751_10	269797.Mbar_A2765	1.028e-78	275.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
MMS1_k127_2195751_27	387631.Asulf_00439	5.476e-32	136.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2463R@183980|Archaeoglobi	183980|Archaeoglobi	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMS1_k127_2195751_34	926561.KB900620_gene2882	5.338e-21	98.0	COG0537@1|root,COG0537@2|Bacteria,1VB6J@1239|Firmicutes,24JZG@186801|Clostridia,3WASW@53433|Halanaerobiales	186801|Clostridia	FG	HIT domain	-	-	-	-	-	-	-	-	-	-	-	-	HIT
MMS1_k127_2195751_39	368408.Tpen_1787	2.777e-13	83.0	COG1750@1|root,arCOG01937@2157|Archaea,2XQAW@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM Lon protease (S16) C-terminal proteolytic domain	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
MMS1_k127_2195751_6	667014.Thein_1193	3.555e-121	402.0	COG1379@1|root,COG1379@2|Bacteria,2GH9W@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2195751_18	1499967.BAYZ01000147_gene697	3.32e-53	192.0	COG1839@1|root,COG1839@2|Bacteria,2NPAQ@2323|unclassified Bacteria	2|Bacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
MMS1_k127_2195751_32	604354.TSIB_1199	2.467e-28	116.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,244BC@183968|Thermococci	183968|Thermococci	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMS1_k127_2195751_48	1121945.ATXS01000003_gene1473	1.675e-05	50.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota,23WQZ@183963|Halobacteria	183963|Halobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS1_k127_2195751_23	1151117.AJLF01000001_gene1719	3.352e-40	158.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,242VW@183968|Thermococci	183968|Thermococci	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
MMS1_k127_2195751_40	555779.Dthio_PD0591	1.098e-12	79.0	COG3173@1|root,COG3173@2|Bacteria,1R8W5@1224|Proteobacteria,42PZM@68525|delta/epsilon subdivisions,2WM50@28221|Deltaproteobacteria,2M8EG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMS1_k127_2195751_29	33876.JNXY01000038_gene8104	2.289e-31	133.0	COG0483@1|root,COG0483@2|Bacteria,2H8ZM@201174|Actinobacteria	201174|Actinobacteria	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
MMS1_k127_2195751_2	436114.SYO3AOP1_0527	5.924e-145	473.0	COG0507@1|root,COG2378@1|root,COG0507@2|Bacteria,COG2378@2|Bacteria	2|Bacteria	K	regulation of single-species biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	Herpes_Helicase,PIF1,UvrD_C_2,WYL
MMS1_k127_2195751_41	1379858.N508_00796	3.221e-12	77.0	COG2510@1|root,COG2510@2|Bacteria	2|Bacteria	EG	membrane	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
MMS1_k127_2195751_15	983917.RGE_32140	1.048e-58	217.0	COG1680@1|root,COG1680@2|Bacteria,1RBWE@1224|Proteobacteria,2W0TX@28216|Betaproteobacteria	28216|Betaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2195751_12	263820.PTO0981	1.336e-77	272.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,241MH@183967|Thermoplasmata	183967|Thermoplasmata	E	Metallopeptidase family M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMS1_k127_2195751_45	218284.CCDN010000002_gene2657	2.558e-06	56.0	COG0494@1|root,COG0494@2|Bacteria,1TYWW@1239|Firmicutes,4I82X@91061|Bacilli,1ZH73@1386|Bacillus	91061|Bacilli	L	NUDIX domain	-	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
MMS1_k127_2195751_7	351160.RRC440	3.209e-109	366.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2NADJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF650	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMS1_k127_2195751_43	565033.GACE_0609	2.029e-11	73.0	COG1407@1|root,arCOG01150@2157|Archaea,2XWNG@28890|Euryarchaeota,24684@183980|Archaeoglobi	183980|Archaeoglobi	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos_2
MMS1_k127_2195751_26	868131.MSWAN_0692	3.362e-32	139.0	COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the peptidase M50B family	-	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
MMS1_k127_2195751_51	1177154.Y5S_02572	0.0009866	50.0	COG0433@1|root,COG0433@2|Bacteria,1NRBN@1224|Proteobacteria,1RU1X@1236|Gammaproteobacteria,1XIPD@135619|Oceanospirillales	135619|Oceanospirillales	D	Domain of unknown function DUF87	-	-	-	ko:K19175	-	-	-	-	ko00000,ko02048	-	-	-	DUF87
MMS1_k127_2195751_37	573064.Mefer_0741	5.02e-17	88.0	COG2178@1|root,arCOG04318@2157|Archaea,2XXNP@28890|Euryarchaeota,23QXW@183939|Methanococci	183939|Methanococci	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
MMS1_k127_2195751_21	642492.Clole_3334	1.48e-46	179.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia	186801|Clostridia	L	8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
MMS1_k127_2195751_8	391623.TERMP_00298	8.677e-92	320.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,242X6@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMS1_k127_2195751_22	273063.STK_12650	1.07e-43	169.0	COG1498@1|root,arCOG01923@2157|Archaea,2XPYC@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMS1_k127_2195751_47	330779.Saci_1329	6.696e-06	52.0	COG0721@1|root,arCOG02726@2157|Archaea,2XSFS@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
MMS1_k127_2195751_11	330779.Saci_1330	9.349e-78	278.0	COG0154@1|root,arCOG01717@2157|Archaea,2XPYP@28889|Crenarchaeota	28889|Crenarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
MMS1_k127_2195751_13	1236689.MMALV_14410	2.281e-72	260.0	COG0064@1|root,arCOG01718@2157|Archaea,2XSV3@28890|Euryarchaeota	28890|Euryarchaeota	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
MMS1_k127_2195751_1	224325.AF_2316	2.889e-175	570.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,245R2@183980|Archaeoglobi	183980|Archaeoglobi	L	Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMS1_k127_2195751_38	351160.RCIX2297	1.678e-15	89.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
MMS1_k127_2195751_35	521011.Mpal_1663	1.431e-18	94.0	COG0467@1|root,arCOG01174@2157|Archaea,2XV95@28890|Euryarchaeota,2N9UG@224756|Methanomicrobia	224756|Methanomicrobia	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
MMS1_k127_2195751_16	647113.Metok_1481	7.536e-58	209.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,23QQ7@183939|Methanococci	183939|Methanococci	K	SMART helix-turn-helix domain protein	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS1_k127_2195751_50	273075.Ta0053	0.0006215	44.0	COG2167@1|root,arCOG04177@2157|Archaea,2Y6WV@28890|Euryarchaeota,241X6@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	-	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMS1_k127_2195751_46	1054217.TALC_00908	5.463e-06	53.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,241XG@183967|Thermoplasmata	183967|Thermoplasmata	S	DNA binding	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
MMS1_k127_2195751_24	579137.Metvu_0351	1.047e-38	148.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,23QVX@183939|Methanococci	183939|Methanococci	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMS1_k127_2195751_17	1365176.N186_03470	1.524e-54	207.0	COG1078@1|root,arCOG04430@2157|Archaea,2XQ25@28889|Crenarchaeota	28889|Crenarchaeota	S	SMART metal-dependent phosphohydrolase, HD region	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMS1_k127_2195751_5	1343739.PAP_07045	3.778e-122	414.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,24339@183968|Thermococci	183968|Thermococci	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMS1_k127_2195751_30	69014.TK2211	3e-30	139.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,242NP@183968|Thermococci	183968|Thermococci	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
MMS1_k127_2195751_44	1236689.MMALV_00680	1.52e-09	60.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y6XW@28890|Euryarchaeota,3F2UA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMS1_k127_2195751_28	1196083.SALWKB12_0746	1.434e-31	129.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,2KR5B@206351|Neisseriales	206351|Neisseriales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
MMS1_k127_2195751_4	1121396.KB893101_gene475	1.687e-122	400.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,42PY3@68525|delta/epsilon subdivisions,2WV23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	-	-	-	-	-	-	-	-	-	-	Thymidylat_synt
MMS1_k127_2195751_3	1410632.JHWW01000011_gene2362	9.448e-132	434.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,27I79@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS1_k127_2195751_33	693661.Arcve_0508	7.045e-23	105.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,245WA@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
MMS1_k127_2195751_14	342949.PNA2_1012	4.557e-71	250.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,242ZG@183968|Thermococci	183968|Thermococci	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS1_k127_2195751_42	579137.Metvu_1545	8.457e-12	69.0	COG1460@1|root,arCOG01016@2157|Archaea,2XXZX@28890|Euryarchaeota,23R3J@183939|Methanococci	183939|Methanococci	K	PFAM RNA polymerase Rpb4	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMS1_k127_2195751_20	70601.3258258	1.318e-48	180.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,242KI@183968|Thermococci	183968|Thermococci	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMS1_k127_2195751_49	374847.Kcr_1592	0.0004585	44.0	COG2139@1|root,arCOG04129@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMS1_k127_2330703_9	710686.Mycsm_04737	1.696e-31	144.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2366T@1762|Mycobacteriaceae	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Lactonase
MMS1_k127_2330703_2	644966.Tmar_0111	5.562e-105	351.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WCH9@538999|Clostridiales incertae sedis	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS1_k127_2330703_7	981369.JQMJ01000001_gene6686	1.923e-39	171.0	COG2373@1|root,COG3391@1|root,COG2373@2|Bacteria,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2NFQM@228398|Streptacidiphilus	201174|Actinobacteria	M	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
MMS1_k127_2330703_3	386456.JQKN01000002_gene2774	7.916e-76	267.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
MMS1_k127_2330703_12	153721.MYP_51	1.507e-18	102.0	COG3405@1|root,COG3866@1|root,COG3405@2|Bacteria,COG3866@2|Bacteria,4PKQF@976|Bacteroidetes,47S4W@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl hydrolases family 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573,Glyco_hydro_8
MMS1_k127_2330703_16	402626.Rpic_3640	1.721e-16	97.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria,1KAIY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
MMS1_k127_2330703_20	1450525.JATV01000017_gene2759	7.92e-05	59.0	COG2911@1|root,COG3209@1|root,COG3595@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3595@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia,2NSCF@237|Flavobacterium	976|Bacteroidetes	M	SprB repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3,SprB
MMS1_k127_2330703_15	397948.Cmaq_1472	9.458e-18	93.0	COG0463@1|root,arCOG01381@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_2330703_4	985053.VMUT_1064	6.268e-69	251.0	COG3119@1|root,arCOG02787@2157|Archaea,2XS3H@28889|Crenarchaeota	28889|Crenarchaeota	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
MMS1_k127_2330703_18	1121373.KB903664_gene2701	2.025e-08	62.0	COG0500@1|root,COG2226@2|Bacteria,4P1XY@976|Bacteroidetes,47U6N@768503|Cytophagia	976|Bacteroidetes	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS1_k127_2330703_1	273116.14325139	1.619e-109	362.0	COG1088@1|root,arCOG01371@2157|Archaea,2XUZX@28890|Euryarchaeota,2421T@183967|Thermoplasmata	183967|Thermoplasmata	M	Polysaccharide biosynthesis protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
MMS1_k127_2330703_19	319795.Dgeo_2654	3.144e-06	59.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	pglH	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006464,GO:0006486,GO:0006487,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.4.1.187,2.4.1.292	ko:K05946,ko:K16701,ko:K17249	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26,GT4	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMS1_k127_2330703_0	1123366.TH3_00400	3.451e-112	374.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TVTA@28211|Alphaproteobacteria,2JR9T@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
MMS1_k127_2330703_17	1123366.TH3_00405	4.143e-16	83.0	2BWTW@1|root,315N7@2|Bacteria,1RABY@1224|Proteobacteria,2U5VH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2330703_11	273057.SSO1621	9.341e-22	108.0	COG0438@1|root,arCOG01411@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	DUF1972,Glyco_transf_4,Glycos_transf_1
MMS1_k127_2330703_14	263820.PTO0296	2.954e-18	95.0	COG0500@1|root,arCOG01400@2157|Archaea,2Y0KF@28890|Euryarchaeota,242C5@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
MMS1_k127_2330703_5	272562.CA_C0536	1.262e-61	220.0	COG3967@1|root,COG3967@2|Bacteria,1VA08@1239|Firmicutes,24II3@186801|Clostridia,36J69@31979|Clostridiaceae	186801|Clostridia	M	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
MMS1_k127_2330703_6	529709.PYCH_17800	7.422e-43	164.0	arCOG05472@1|root,arCOG05472@2157|Archaea,2XZ9X@28890|Euryarchaeota,243YC@183968|Thermococci	183968|Thermococci	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2330703_8	1459636.NTE_00421	1.054e-34	134.0	COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
MMS1_k127_2330703_10	273075.Ta0067	2.921e-26	120.0	COG1814@1|root,arCOG01096@2157|Archaea,2XWEX@28890|Euryarchaeota,2423V@183967|Thermoplasmata	183967|Thermoplasmata	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
MMS1_k127_2330703_13	511062.GU3_10810	2.223e-18	93.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1Y3UT@135624|Aeromonadales	135624|Aeromonadales	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
MMS1_k127_2377142_0	1459636.NTE_03216	3.664e-192	627.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS1_k127_2377142_10	573370.DMR_06070	1.015e-16	89.0	COG2199@1|root,COG2199@2|Bacteria,1NYG9@1224|Proteobacteria,42U6E@68525|delta/epsilon subdivisions,2WTRT@28221|Deltaproteobacteria,2MANM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Protoglobin	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Protoglobin
MMS1_k127_2377142_5	1392486.JIAF01000004_gene1655	1.526e-35	142.0	COG2096@1|root,COG2096@2|Bacteria,4NFHQ@976|Bacteroidetes,2FQJ0@200643|Bacteroidia	976|Bacteroidetes	S	ATP cob(I)alamin adenosyltransferase	cobO	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
MMS1_k127_2377142_9	1041930.Mtc_0990	6.621e-18	89.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2N9UX@224756|Methanomicrobia	224756|Methanomicrobia	K	Segregation and condensation complex subunit ScpB	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMS1_k127_2377142_8	1041930.Mtc_0991	3.521e-20	99.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2N9X2@224756|Methanomicrobia	224756|Methanomicrobia	L	Segregation and condensation protein ScpA	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMS1_k127_2377142_1	1459636.NTE_03539	6.996e-138	456.0	COG1012@1|root,arCOG01252@2157|Archaea,41T12@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS1_k127_2377142_7	1223410.KN050846_gene1226	9.936e-21	96.0	COG1430@1|root,COG1430@2|Bacteria,4NQ5G@976|Bacteroidetes,1I2TF@117743|Flavobacteriia	976|Bacteroidetes	S	acr, cog1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
MMS1_k127_2377142_4	1094980.Mpsy_0887	5.948e-36	147.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS1_k127_2377142_6	1121129.KB903359_gene2221	1.159e-33	138.0	COG0500@1|root,COG2226@2|Bacteria,4NEDR@976|Bacteroidetes,2FMI3@200643|Bacteroidia,22XH4@171551|Porphyromonadaceae	976|Bacteroidetes	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS1_k127_2377142_12	1041930.Mtc_2034	1.315e-07	59.0	COG1371@1|root,arCOG04055@2157|Archaea,2XXRX@28890|Euryarchaeota,2NA1Z@224756|Methanomicrobia	224756|Methanomicrobia	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
MMS1_k127_2377142_3	263820.PTO1020	2.809e-71	252.0	COG0494@1|root,COG1573@1|root,arCOG00905@2157|Archaea,arCOG01078@2157|Archaea,2XUVI@28890|Euryarchaeota,242GY@183967|Thermoplasmata	183967|Thermoplasmata	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS1_k127_2377142_11	1293047.CBMA010000014_gene833	6.092e-12	72.0	COG0346@1|root,arCOG02708@2157|Archaea,2XYB6@28890|Euryarchaeota,23WDX@183963|Halobacteria	183963|Halobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
MMS1_k127_2377142_2	710686.Mycsm_04737	1.344e-73	281.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,2366T@1762|Mycobacteriaceae	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Lactonase
MMS1_k127_2392066_1	530564.Psta_2038	1.595e-20	103.0	COG1236@1|root,COG1236@2|Bacteria,2IY6Y@203682|Planctomycetes	203682|Planctomycetes	L	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	RMMBL
MMS1_k127_2392066_0	679926.Mpet_2567	3.018e-46	174.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS1_k127_2473300_10	573063.Metin_0253	2.543e-64	235.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,23Q03@183939|Methanococci	183939|Methanococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rad17
MMS1_k127_2473300_7	573063.Metin_1118	5.64e-97	337.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,23QRD@183939|Methanococci	183939|Methanococci	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
MMS1_k127_2473300_8	386456.JQKN01000002_gene2422	3.809e-92	320.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,23NUT@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMS1_k127_2473300_20	1161401.ASJA01000014_gene1068	1.378e-11	67.0	COG2388@1|root,COG2388@2|Bacteria,1N316@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferase	HA62_12640	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
MMS1_k127_2473300_21	386456.JQKN01000015_gene2935	2.336e-06	59.0	COG0681@1|root,arCOG01739@2157|Archaea,2XYEA@28890|Euryarchaeota,23P1Z@183925|Methanobacteria	183925|Methanobacteria	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
MMS1_k127_2473300_6	243232.MJ_1643	2.555e-98	359.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,23Q4M@183939|Methanococci	183939|Methanococci	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS1_k127_2473300_5	243232.MJ_0985	4.243e-101	336.0	COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,23RNE@183939|Methanococci	183939|Methanococci	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS1_k127_2473300_11	1158338.JNLJ01000005_gene1607	2.185e-62	220.0	2BUSS@1|root,32Q45@2|Bacteria	2|Bacteria	L	MjaI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_MjaI
MMS1_k127_2473300_22	592029.DDD_0426	5.983e-05	56.0	COG0433@1|root,COG0433@2|Bacteria,4NF3P@976|Bacteroidetes,1HX0B@117743|Flavobacteriia,3HJGJ@363408|Nonlabens	976|Bacteroidetes	S	Type IV secretion-system coupling protein DNA-binding domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
MMS1_k127_2473300_3	1459636.NTE_02657	4.856e-113	381.0	COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2473300_19	439481.Aboo_0929	1.291e-14	75.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,3F2TZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
MMS1_k127_2473300_13	304371.MCP_0135	3.192e-43	166.0	COG0463@1|root,arCOG01385@2157|Archaea,2Y0V7@28890|Euryarchaeota,2NB3P@224756|Methanomicrobia	224756|Methanomicrobia	M	N-terminal domain of galactosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS1_k127_2473300_0	342949.PNA2_1501	5.88e-211	694.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,242NA@183968|Thermococci	183968|Thermococci	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS1_k127_2473300_9	523850.TON_1557	3.827e-89	309.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,243CJ@183968|Thermococci	183968|Thermococci	J	methylthiotransferase activity	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
MMS1_k127_2473300_4	186497.PF1461	7.154e-111	373.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2439K@183968|Thermococci	183968|Thermococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMS1_k127_2473300_2	243232.MJ_0019	1.518e-128	432.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,23QDW@183939|Methanococci	183939|Methanococci	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
MMS1_k127_2473300_15	1267535.KB906767_gene4264	6.614e-42	162.0	COG2013@1|root,COG2013@2|Bacteria,3Y2XF@57723|Acidobacteria,2JIE5@204432|Acidobacteriia	204432|Acidobacteriia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
MMS1_k127_2473300_16	997350.HMPREF9129_2066	9.095e-27	117.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,22HGQ@1570339|Peptoniphilaceae	186801|Clostridia	L	Hydrolase, NUDIX family	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
MMS1_k127_2473300_18	311424.DhcVS_159	3.572e-22	104.0	COG1451@1|root,COG1451@2|Bacteria,2G7C0@200795|Chloroflexi,34CZ9@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
MMS1_k127_2473300_1	604354.TSIB_0532	8.56e-164	533.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,243N1@183968|Thermococci	183968|Thermococci	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2,Intein_splicing,LAGLIDADG_3
MMS1_k127_2473300_12	999630.TUZN_2170	3.85e-44	167.0	COG0105@1|root,arCOG04313@2157|Archaea,2XQEV@28889|Crenarchaeota	28889|Crenarchaeota	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMS1_k127_2473300_17	1150474.JQJI01000002_gene1102	4.252e-26	111.0	COG2151@1|root,COG2151@2|Bacteria,2GDA3@200918|Thermotogae	200918|Thermotogae	S	metal-sulfur cluster biosynthetic	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS1_k127_2473300_23	797209.ZOD2009_13106	0.0002758	55.0	arCOG02545@1|root,arCOG02545@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,PKD
MMS1_k127_2629032_9	273075.Ta1250m	3.403e-23	105.0	COG1841@1|root,arCOG04086@2157|Archaea,2XWGP@28890|Euryarchaeota,241SM@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl30	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMS1_k127_2629032_15	272844.PAB2138	3.859e-15	80.0	COG0200@1|root,arCOG00779@2157|Archaea,2XWM3@28890|Euryarchaeota,243K6@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl15	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMS1_k127_2629032_5	373903.Hore_17190	2.922e-55	208.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,3WAPF@53433|Halanaerobiales	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_2629032_2	339860.Msp_0281	1.266e-86	302.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
MMS1_k127_2629032_21	153721.MYP_4858	1.352e-05	56.0	COG4733@1|root,COG4733@2|Bacteria,4NTXR@976|Bacteroidetes,47SSC@768503|Cytophagia	976|Bacteroidetes	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Laminin_G_3
MMS1_k127_2629032_11	314285.KT71_05877	7.408e-20	98.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,1MY51@1224|Proteobacteria,1SWNI@1236|Gammaproteobacteria,1J917@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,HAD
MMS1_k127_2629032_17	330779.Saci_1420	2.467e-10	64.0	COG1254@1|root,arCOG01674@2157|Archaea,2XR8S@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM acylphosphatase	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMS1_k127_2629032_18	1094980.Mpsy_2745	7.154e-10	66.0	arCOG05152@1|root,arCOG05152@2157|Archaea,2XZHZ@28890|Euryarchaeota,2N9VI@224756|Methanomicrobia	224756|Methanomicrobia	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,HTH_5
MMS1_k127_2629032_10	1379698.RBG1_1C00001G1490	7.801e-23	105.0	COG0576@1|root,COG0576@2|Bacteria,2NPSS@2323|unclassified Bacteria	2|Bacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMS1_k127_2629032_0	224719.Abm4_1617	5.26e-242	762.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,23NSE@183925|Methanobacteria	183925|Methanobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS1_k127_2629032_3	339860.Msp_1516	1.478e-75	267.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,23NRW@183925|Methanobacteria	183925|Methanobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMS1_k127_2629032_20	195522.BD01_1592	1.359e-08	60.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,244AW@183968|Thermococci	183968|Thermococci	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
MMS1_k127_2629032_13	694440.JOMF01000006_gene409	1.022e-15	84.0	COG0693@1|root,arCOG00769@2157|Archaea,2XTPH@28890|Euryarchaeota,2N9U0@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM intracellular protease, PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
MMS1_k127_2629032_19	1198449.ACAM_1512	1.273e-08	68.0	arCOG03671@1|root,arCOG03671@2157|Archaea	2157|Archaea	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Thermopsin
MMS1_k127_2629032_8	456320.Mvol_0838	4.726e-26	117.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,23QQW@183939|Methanococci	183939|Methanococci	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMS1_k127_2629032_14	5888.CAK59941	3.241e-15	85.0	COG0592@1|root,KOG1636@2759|Eukaryota,3ZBEF@5878|Ciliophora	5878|Ciliophora	L	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand	-	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
MMS1_k127_2629032_16	868131.MSWAN_1780	3.097e-11	67.0	COG1849@1|root,arCOG01224@2157|Archaea,2Y279@28890|Euryarchaeota,23P92@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
MMS1_k127_2629032_6	877455.Metbo_0334	1.107e-52	200.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,23NVN@183925|Methanobacteria	183925|Methanobacteria	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMS1_k127_2629032_12	396588.Tgr7_0574	3.269e-16	88.0	COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales	135613|Chromatiales	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,DUF3335
MMS1_k127_2629032_1	439481.Aboo_0966	5.637e-167	537.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,3F2GK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	tRNA-splicing ligase RtcB	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
MMS1_k127_2629032_4	1042877.GQS_08995	1.183e-59	214.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,24333@183968|Thermococci	183968|Thermococci	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	GO:0000154,GO:0000494,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006325,GO:0006364,GO:0006396,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008213,GO:0008276,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016074,GO:0016569,GO:0016570,GO:0016571,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0022613,GO:0031123,GO:0031126,GO:0031167,GO:0032259,GO:0033967,GO:0034470,GO:0034641,GO:0034660,GO:0034963,GO:0036009,GO:0036211,GO:0042054,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043414,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051276,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140096,GO:0140098,GO:0140102,GO:1901360,GO:1901363,GO:1901564,GO:1990258,GO:1990259	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMS1_k127_2629032_7	700598.Niako_1148	5.163e-42	178.0	COG0784@1|root,COG5002@1|root,COG5278@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,4PKV1@976|Bacteroidetes	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg
MMS1_k127_2642149_37	694429.Pyrfu_0169	1.68e-05	47.0	COG1491@1|root,arCOG04130@2157|Archaea,2XQPC@28889|Crenarchaeota	28889|Crenarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMS1_k127_2642149_34	529709.PYCH_05980	1.576e-07	56.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,244BJ@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMS1_k127_2642149_23	1365176.N186_02405	2.481e-21	97.0	COG2101@1|root,arCOG01764@2157|Archaea,2XQ5U@28889|Crenarchaeota	28889|Crenarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMS1_k127_2642149_10	484019.THA_138	2.184e-60	213.0	COG0503@1|root,COG0503@2|Bacteria,2GCSE@200918|Thermotogae	200918|Thermotogae	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
MMS1_k127_2642149_13	1449080.JQMV01000003_gene233	3.848e-49	183.0	COG0020@1|root,COG0020@2|Bacteria,1WI97@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
MMS1_k127_2642149_21	224719.Abm4_1285	1.441e-26	126.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,23NN7@183925|Methanobacteria	183925|Methanobacteria	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMS1_k127_2642149_33	224324.aq_1542	1.441e-08	66.0	COG0170@1|root,COG0170@2|Bacteria,2G5BD@200783|Aquificae	200783|Aquificae	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2642149_8	717231.Flexsi_0211	1.015e-60	227.0	COG1008@1|root,COG1008@2|Bacteria,2GF24@200930|Deferribacteres	200930|Deferribacteres	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
MMS1_k127_2642149_5	272557.APE_1367	3.857e-102	366.0	COG0464@1|root,arCOG01308@2157|Archaea,2XPXJ@28889|Crenarchaeota	28889|Crenarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
MMS1_k127_2642149_38	1280696.ATVY01000020_gene2916	3.212e-05	55.0	COG0582@1|root,COG0582@2|Bacteria,1VJCV@1239|Firmicutes,24F0P@186801|Clostridia,4BZPW@830|Butyrivibrio	186801|Clostridia	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
MMS1_k127_2642149_11	643648.Slip_1594	7.651e-53	197.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria	2|Bacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS1_k127_2642149_24	243232.MJ_ECL38	1.533e-17	94.0	COG5378@1|root,arCOG02121@2157|Archaea	2157|Archaea	S	PFAM Nucleotide-binding protein, PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_2
MMS1_k127_2642149_9	263820.PTO0291	1.961e-60	229.0	arCOG05334@1|root,arCOG05334@2157|Archaea,2Y3MV@28890|Euryarchaeota,2427R@183967|Thermoplasmata	183967|Thermoplasmata	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2642149_30	946077.W5A_10684	4.169e-11	75.0	2C99D@1|root,2Z7Y8@2|Bacteria,4NFS4@976|Bacteroidetes	976|Bacteroidetes	S	DNA-sulfur modification-associated	-	-	-	-	-	-	-	-	-	-	-	-	DndB
MMS1_k127_2642149_40	195522.BD01_0623	5.988e-05	53.0	COG1694@1|root,arCOG01084@2157|Archaea,2XZ0S@28890|Euryarchaeota,244B1@183968|Thermococci	183968|Thermococci	S	MazG nucleotide pyrophosphohydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	MazG
MMS1_k127_2642149_35	762983.HMPREF9444_01924	2.249e-07	59.0	COG0494@1|root,COG0494@2|Bacteria,1QTT1@1224|Proteobacteria,1T1G5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	NUDIX hydrolase	yfcD	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_2642149_22	1304284.L21TH_0086	3.289e-23	102.0	COG4997@1|root,COG4997@2|Bacteria,1VEG6@1239|Firmicutes,24QRF@186801|Clostridia,36KRV@31979|Clostridiaceae	186801|Clostridia	S	phosphoribosyl-ATP pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF429,MazG-like
MMS1_k127_2642149_27	1250232.JQNJ01000001_gene2880	5.62e-16	82.0	2EG6W@1|root,339YS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ASCH
MMS1_k127_2642149_0	386456.JQKN01000019_gene1316	1.938e-184	596.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,23NSS@183925|Methanobacteria	183925|Methanobacteria	S	Beta-Casp domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B_6,RMMBL
MMS1_k127_2642149_12	647113.Metok_0978	1.085e-52	193.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,23QK3@183939|Methanococci	183939|Methanococci	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMS1_k127_2642149_39	1459636.NTE_01688	4.901e-05	49.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
MMS1_k127_2642149_15	269797.Mbar_A2493	8.639e-41	173.0	arCOG03981@1|root,arCOG03981@2157|Archaea,2Y4K9@28890|Euryarchaeota,2NB6J@224756|Methanomicrobia	224756|Methanomicrobia	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2642149_25	765177.Desmu_0428	1.616e-16	93.0	COG2244@1|root,arCOG02209@2157|Archaea,2XQQ1@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
MMS1_k127_2642149_17	186497.PF0058	2.661e-31	132.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMS1_k127_2642149_1	944480.ATUV01000002_gene314	1.765e-153	501.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2M6DB@213113|Desulfurellales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
MMS1_k127_2642149_7	933801.Ahos_2186	3.697e-64	224.0	COG0221@1|root,arCOG01711@2157|Archaea,2XQB5@28889|Crenarchaeota	28889|Crenarchaeota	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
MMS1_k127_2642149_14	186497.PF1392	2.155e-42	165.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,243BD@183968|Thermococci	183968|Thermococci	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS1_k127_2642149_3	243232.MJ_0370	2.857e-108	361.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,23Q86@183939|Methanococci	183939|Methanococci	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS1_k127_2642149_6	5932.XP_004029845.1	3.549e-86	297.0	COG0162@1|root,KOG2144@2759|Eukaryota,3ZBI3@5878|Ciliophora	5878|Ciliophora	J	tRNA synthetases class I (W and Y)	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMS1_k127_2642149_41	1158345.JNLL01000001_gene1112	0.0005229	53.0	COG1807@1|root,COG1807@2|Bacteria,2G3ZV@200783|Aquificae	200783|Aquificae	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
MMS1_k127_2642149_20	1278073.MYSTI_01714	5.067e-28	120.0	COG3545@1|root,COG3545@2|Bacteria,1RKTI@1224|Proteobacteria,42TNI@68525|delta/epsilon subdivisions,2X8Y2@28221|Deltaproteobacteria,2Z0ZR@29|Myxococcales	28221|Deltaproteobacteria	S	Serine hydrolase	-	-	-	ko:K07002	-	-	-	-	ko00000	-	-	-	Ser_hydrolase
MMS1_k127_2642149_36	243232.MJ_0514	7.993e-06	53.0	COG1145@1|root,arCOG02179@2157|Archaea,2XW8N@28890|Euryarchaeota,23QDT@183939|Methanococci	183939|Methanococci	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS1_k127_2642149_32	273057.SSO2735	1.436e-09	68.0	COG0288@1|root,arCOG02860@2157|Archaea	2157|Archaea	P	carbonic anhydrase	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
MMS1_k127_2642149_2	273075.Ta0519	3.968e-123	408.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,241ZH@183967|Thermoplasmata	183967|Thermoplasmata	J	asparaginyl-tRNA aminoacylation	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS1_k127_2642149_4	439481.Aboo_0490	2.383e-102	343.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,3F2GZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMS1_k127_2642149_26	647113.Metok_0923	1.814e-16	85.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,23QX1@183939|Methanococci	183939|Methanococci	K	PFAM helix-turn-helix domain protein	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
MMS1_k127_2642149_19	1343739.PAP_03035	4.073e-28	116.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,242K4@183968|Thermococci	183968|Thermococci	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS1_k127_2642149_29	933801.Ahos_1240	1.595e-14	83.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS1_k127_2642149_16	573063.Metin_0698	1.364e-34	139.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,23QJ9@183939|Methanococci	183939|Methanococci	K	SMART RNA polymerase, RpoA D Rpb3-type	rpoD	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
MMS1_k127_2694124_11	1235793.C809_00001	2.941e-10	66.0	2AU0F@1|root,31JKB@2|Bacteria,1V6XX@1239|Firmicutes,24KKM@186801|Clostridia	186801|Clostridia	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2694124_14	6669.EFX60253	3.222e-06	49.0	2DZEY@1|root,2S6ZB@2759|Eukaryota,3A8VS@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2694124_12	3880.AES84212	4.239e-07	52.0	2E30T@1|root,2SA69@2759|Eukaryota,37XUE@33090|Viridiplantae,3GMF3@35493|Streptophyta,4JVFX@91835|fabids	35493|Streptophyta	S	Cell wall-associated hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2694124_13	643473.KB235930_gene540	1.289e-06	51.0	2A7FA@1|root,30WCV@2|Bacteria,1GFDD@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_2694124_2	710686.Mycsm_06185	5.94e-67	262.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,23EVE@1762|Mycobacteriaceae	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS1_k127_2694124_9	1173020.Cha6605_2034	9.746e-14	84.0	COG0433@1|root,COG0433@2|Bacteria,1G1AD@1117|Cyanobacteria	1117|Cyanobacteria	S	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,TrwB_AAD_bind
MMS1_k127_2694124_3	368407.Memar_0638	2.665e-59	216.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS1_k127_2694124_6	263820.PTO1172	2.736e-22	107.0	arCOG03425@1|root,arCOG03425@2157|Archaea	2157|Archaea	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_2694124_7	530564.Psta_2038	5.58e-19	98.0	COG1236@1|root,COG1236@2|Bacteria,2IY6Y@203682|Planctomycetes	203682|Planctomycetes	L	Exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	RMMBL
MMS1_k127_2694124_5	710421.Mycch_1193	3.687e-32	147.0	COG2373@1|root,COG3391@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2GK45@201174|Actinobacteria,2366T@1762|Mycobacteriaceae	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Lactonase
MMS1_k127_2694124_0	644966.Tmar_0111	1.607e-105	351.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WCH9@538999|Clostridiales incertae sedis	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS1_k127_2694124_1	877455.Metbo_0552	1.652e-76	269.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
MMS1_k127_2694124_8	153721.MYP_51	2.248e-15	91.0	COG3405@1|root,COG3866@1|root,COG3405@2|Bacteria,COG3866@2|Bacteria,4PKQF@976|Bacteroidetes,47S4W@768503|Cytophagia	976|Bacteroidetes	M	Glycosyl hydrolases family 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573,Glyco_hydro_8
MMS1_k127_2694124_4	673862.BABL1_1000	4.057e-46	195.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
MMS1_k127_2694124_10	1121373.KB903663_gene1221	5.703e-11	78.0	COG3405@1|root,COG5184@1|root,COG3405@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,CHU_C,DUF3494,Glyco_hydro_8,RCC1,RCC1_2
MMS1_k127_288537_7	79684.XP_005355606.1	2.293e-06	52.0	COG0596@1|root,COG1011@1|root,KOG3085@2759|Eukaryota,KOG4178@2759|Eukaryota,39WAD@33154|Opisthokonta,3BACN@33208|Metazoa,3CVBC@33213|Bilateria,482KF@7711|Chordata,48X7C@7742|Vertebrata,3JCRV@40674|Mammalia,35C45@314146|Euarchontoglires,4PSX8@9989|Rodentia	33208|Metazoa	I	Epoxide hydrolase 2	EPHX2	GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003018,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006633,GO:0006690,GO:0006725,GO:0006793,GO:0006796,GO:0006805,GO:0006810,GO:0006873,GO:0006874,GO:0006875,GO:0006886,GO:0006950,GO:0006952,GO:0006954,GO:0006996,GO:0007031,GO:0007600,GO:0008015,GO:0008104,GO:0008150,GO:0008152,GO:0008217,GO:0008610,GO:0009056,GO:0009058,GO:0009410,GO:0009636,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015031,GO:0015643,GO:0015833,GO:0016043,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0017144,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019369,GO:0019373,GO:0019439,GO:0019725,GO:0019752,GO:0030003,GO:0030258,GO:0031907,GO:0031974,GO:0032501,GO:0032787,GO:0033036,GO:0033365,GO:0033559,GO:0034613,GO:0035150,GO:0035296,GO:0042221,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042759,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0045777,GO:0046272,GO:0046394,GO:0046483,GO:0046839,GO:0046872,GO:0046907,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050801,GO:0050877,GO:0050880,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0070013,GO:0070727,GO:0070887,GO:0071466,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072330,GO:0072503,GO:0072507,GO:0072593,GO:0072594,GO:0072662,GO:0072663,GO:0080090,GO:0090066,GO:0090181,GO:0097176,GO:0097746,GO:0097755,GO:0098771,GO:1900673,GO:1901360,GO:1901361,GO:1901568,GO:1901575,GO:1901576	3.1.3.76,3.3.2.10	ko:K08726,ko:K10089	ko00590,ko00625,ko01100,ko01120,ko04142,ko04145,ko04146,map00590,map00625,map01100,map01120,map04142,map04145,map04146	-	R05842,R07108,R07109,R07110,R07111	RC01477,RC01757	ko00000,ko00001,ko01000,ko01002,ko01009,ko04091,ko04147	-	-	-	Abhydrolase_1,HAD_2
MMS1_k127_288537_2	1048983.EL17_21770	9.625e-49	183.0	COG1305@1|root,COG1305@2|Bacteria,4NPWW@976|Bacteroidetes,47RR7@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
MMS1_k127_288537_3	391623.TERMP_01829	5.407e-34	138.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,243RS@183968|Thermococci	183968|Thermococci	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS1_k127_288537_5	693661.Arcve_0166	3.965e-19	94.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,24673@183980|Archaeoglobi	183980|Archaeoglobi	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036222,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS1_k127_288537_6	866775.HMPREF9243_1429	7.491e-07	59.0	COG2227@1|root,COG2227@2|Bacteria,1V218@1239|Firmicutes,4ISKI@91061|Bacilli,27DWQ@186827|Aerococcaceae	91061|Bacilli	H	Methyltransferase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS1_k127_288537_0	263820.PTO0034	5.812e-74	257.0	COG2253@1|root,arCOG03839@2157|Archaea,2XWPU@28890|Euryarchaeota	28890|Euryarchaeota	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	ko:K09144	-	-	-	-	ko00000	-	-	-	AbiEii
MMS1_k127_288537_1	263820.PTO0033	3.199e-56	202.0	COG5340@1|root,arCOG04793@2157|Archaea,2XVVB@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4
MMS1_k127_288537_4	406327.Mevan_1608	2.619e-29	128.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,23QFU@183939|Methanococci	183939|Methanococci	J	PFAM elongation factor Tu, domain 2 protein	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
MMS1_k127_29112_2	1123371.ATXH01000003_gene1930	2.139e-07	57.0	COG1011@1|root,COG1011@2|Bacteria,2GGQR@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS1_k127_29112_0	706587.Desti_3632	5.536e-21	98.0	COG1443@1|root,COG1443@2|Bacteria,1PYKE@1224|Proteobacteria,437Z8@68525|delta/epsilon subdivisions,2X396@28221|Deltaproteobacteria,2MSGJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	NUDIX domain	-	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
MMS1_k127_29112_1	56110.Oscil6304_1711	6.827e-19	94.0	COG2227@1|root,COG2227@2|Bacteria,1GQ6N@1117|Cyanobacteria	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS1_k127_29112_3	634498.mru_1224	6.845e-05	52.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,23P67@183925|Methanobacteria	183925|Methanobacteria	H	AAA domain	coaE	-	-	-	-	-	-	-	-	-	-	-	AAA_17
MMS1_k127_29112_4	97139.C824_05202	0.0001026	48.0	COG5421@1|root,COG5421@2|Bacteria,1V4M5@1239|Firmicutes,24F9B@186801|Clostridia,36R33@31979|Clostridiaceae	186801|Clostridia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
MMS1_k127_407720_0	1459636.NTE_00289	6.107e-90	310.0	COG3039@1|root,arCOG02751@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
MMS1_k127_490312_1	710421.Mycch_1193	2.012e-64	253.0	COG2373@1|root,COG3391@1|root,COG4932@1|root,COG2373@2|Bacteria,COG3391@2|Bacteria,COG4932@2|Bacteria,2GK45@201174|Actinobacteria,2366T@1762|Mycobacteriaceae	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Lactonase
MMS1_k127_490312_0	710686.Mycsm_06185	4.777e-72	280.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,23EVE@1762|Mycobacteriaceae	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS1_k127_728943_3	710686.Mycsm_06185	6.786e-62	246.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,23EVE@1762|Mycobacteriaceae	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
MMS1_k127_728943_4	1278311.AUAL01000024_gene837	3.858e-14	82.0	COG1192@1|root,COG1192@2|Bacteria,3WTGQ@544448|Tenericutes	544448|Tenericutes	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
MMS1_k127_728943_5	273116.14325504	5.304e-10	61.0	COG5466@1|root,arCOG05278@2157|Archaea,2Y5U3@28890|Euryarchaeota,242H8@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMS1_k127_728943_0	572546.Arcpr_0164	1.505e-203	651.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,246NI@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
MMS1_k127_728943_2	397948.Cmaq_0169	4.089e-105	356.0	COG0358@1|root,arCOG04281@2157|Archaea,2XPXM@28889|Crenarchaeota	28889|Crenarchaeota	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMS1_k127_728943_1	479431.Namu_1550	5.079e-121	394.0	COG0498@1|root,COG0498@2|Bacteria,2GNM0@201174|Actinobacteria,4ERP2@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM Threonine synthase	thrC3	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS1_k127_85296_37	698757.Pogu_0049	8.126e-39	151.0	COG0717@1|root,arCOG04048@2157|Archaea,2XQDF@28889|Crenarchaeota	28889|Crenarchaeota	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
MMS1_k127_85296_73	410358.Mlab_0758	1.929e-05	51.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,2N9Y7@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS1_k127_85296_55	387631.Asulf_01850	1.063e-15	89.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,246AR@183980|Archaeoglobi	183980|Archaeoglobi	J	tRNA intron endonuclease	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
MMS1_k127_85296_54	1382306.JNIM01000001_gene724	4.924e-16	89.0	COG0392@1|root,COG0392@2|Bacteria,2G6EN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
MMS1_k127_85296_38	1220534.B655_1691	6.805e-38	152.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,23NX5@183925|Methanobacteria	183925|Methanobacteria	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
MMS1_k127_85296_13	1343739.PAP_10275	1.058e-106	355.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,242UY@183968|Thermococci	183968|Thermococci	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Intein_splicing,LAGLIDADG_3,Rad51
MMS1_k127_85296_50	406327.Mevan_1343	9.045e-19	95.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,23QC3@183939|Methanococci	183939|Methanococci	S	Integral membrane protein DUF92	-	GO:0005575,GO:0016020	-	-	-	-	-	-	-	-	-	-	DUF92
MMS1_k127_85296_15	436308.Nmar_0248	8.098e-90	305.0	COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS1_k127_85296_56	572478.Vdis_0462	9.519e-15	87.0	COG2244@1|root,arCOG02209@2157|Archaea,2XQBN@28889|Crenarchaeota	28889|Crenarchaeota	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
MMS1_k127_85296_34	439481.Aboo_1150	8.509e-41	160.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,3F2K5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMS1_k127_85296_46	647113.Metok_0533	1.367e-29	127.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,23PZU@183939|Methanococci	183939|Methanococci	J	Translation initiation factor 2	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMS1_k127_85296_69	342949.PNA2_0865	1.023e-09	64.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,244C9@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMS1_k127_85296_64	589924.Ferp_0244	1.469e-11	74.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2467Q@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
MMS1_k127_85296_31	1459636.NTE_02210	2.849e-48	184.0	COG0010@1|root,arCOG01700@2157|Archaea,41T23@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS1_k127_85296_4	2325.TKV_c00090	1.126e-220	702.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,42EPA@68295|Thermoanaerobacterales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS1_k127_85296_3	598659.NAMH_0664	2.944e-230	737.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2YMS4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS1_k127_85296_8	304371.MCP_0129	8.169e-165	551.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2N90P@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS1_k127_85296_75	1054217.TALC_00322	0.00027	48.0	COG1382@1|root,arCOG01342@2157|Archaea,2Y79P@28890|Euryarchaeota,241WC@183967|Thermoplasmata	183967|Thermoplasmata	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMS1_k127_85296_74	4899.EPX73504	0.0002654	48.0	COG1369@1|root,KOG4639@2759|Eukaryota,3A8A9@33154|Opisthokonta,3P7BH@4751|Fungi,3QVRD@4890|Ascomycota,3MD5H@451866|Taphrinomycotina	4751|Fungi	J	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP	POP5	GO:0000172,GO:0000294,GO:0000447,GO:0000460,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006402,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016074,GO:0018065,GO:0018193,GO:0018205,GO:0019222,GO:0019439,GO:0019538,GO:0022613,GO:0030490,GO:0030677,GO:0030681,GO:0031070,GO:0031974,GO:0031981,GO:0032991,GO:0033967,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034963,GO:0034965,GO:0036211,GO:0042254,GO:0042274,GO:0043144,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0051604,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901575,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
MMS1_k127_85296_70	751944.HALDL1_04080	2.371e-08	60.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTJP@28890|Euryarchaeota,23U8X@183963|Halobacteria	183963|Halobacteria	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	rpa2	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	REPA_OB_2,tRNA_anti-codon
MMS1_k127_85296_17	673860.AciM339_0074	6.072e-89	308.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,3F2F9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Beta-Casp domain	epf1	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL
MMS1_k127_85296_41	387631.Asulf_01085	2.09e-34	139.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246Y6@183980|Archaeoglobi	183980|Archaeoglobi	C	CoA binding domain	-	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
MMS1_k127_85296_10	604354.TSIB_1965	1.588e-121	404.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,242W1@183968|Thermococci	183968|Thermococci	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2,Succ_CoA_lig
MMS1_k127_85296_52	868864.Dester_0334	3.793e-18	97.0	COG0420@1|root,COG0420@2|Bacteria,2G45D@200783|Aquificae	200783|Aquificae	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
MMS1_k127_85296_21	342949.PNA2_0654	5.436e-76	269.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,242PQ@183968|Thermococci	183968|Thermococci	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
MMS1_k127_85296_27	573063.Metin_0119	4.509e-58	212.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,23QCR@183939|Methanococci	183939|Methanococci	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
MMS1_k127_85296_28	572546.Arcpr_0509	1.578e-57	207.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,246RW@183980|Archaeoglobi	183980|Archaeoglobi	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMS1_k127_85296_26	439481.Aboo_0184	2.712e-59	213.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,3F2JN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
MMS1_k127_85296_42	1042877.GQS_05115	4.601e-34	138.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,242IU@183968|Thermococci	183968|Thermococci	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6
MMS1_k127_85296_20	1183377.Py04_1444	1.574e-76	263.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,242PZ@183968|Thermococci	183968|Thermococci	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS1_k127_85296_24	634498.mru_1352	7.423e-61	219.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,23NYE@183925|Methanobacteria	183925|Methanobacteria	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS1_k127_85296_57	342949.PNA2_0520	1.128e-13	73.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,244K8@183968|Thermococci	183968|Thermococci	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMS1_k127_85296_71	436308.Nmar_1592	4.005e-08	59.0	arCOG07348@1|root,arCOG07348@2157|Archaea,41SUQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_85296_72	523841.HFX_0625	6.06e-06	50.0	COG1996@1|root,arCOG04341@2157|Archaea,2XZUD@28890|Euryarchaeota,23XRR@183963|Halobacteria	183963|Halobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
MMS1_k127_85296_44	469378.Ccur_08920	2.958e-30	122.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4CWAM@84998|Coriobacteriia	84998|Coriobacteriia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMS1_k127_85296_23	1237149.C900_04376	2.811e-70	254.0	COG0124@1|root,COG0124@2|Bacteria,4NE8N@976|Bacteroidetes,47KPD@768503|Cytophagia	976|Bacteroidetes	J	tRNA synthetase class II core domain (G, H, P, S and T)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMS1_k127_85296_40	868131.MSWAN_0290	8.326e-37	153.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,23NUG@183925|Methanobacteria	183925|Methanobacteria	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
MMS1_k127_85296_65	1006006.Mcup_0430	1.816e-11	78.0	COG1287@1|root,arCOG02044@2157|Archaea,2XQVE@28889|Crenarchaeota	28889|Crenarchaeota	M	Oligosaccharyl transferase, STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
MMS1_k127_85296_35	224325.AF_0043	1.186e-40	165.0	COG0438@1|root,arCOG01403@2157|Archaea,2XVUJ@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS1_k127_85296_5	391623.TERMP_02050	1.569e-192	616.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,242UA@183968|Thermococci	183968|Thermococci	O	Belongs to the TCP-1 chaperonin family	ths	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS1_k127_85296_51	456320.Mvol_0902	1.775e-18	93.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,23Q7F@183939|Methanococci	183939|Methanococci	F	ATP-AMP transphosphorylase	adkA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
MMS1_k127_85296_62	243232.MJ_0655	6.677e-12	70.0	COG2174@1|root,arCOG04168@2157|Archaea,2Y0IH@28890|Euryarchaeota,23R6M@183939|Methanococci	183939|Methanococci	J	Belongs to the eukaryotic ribosomal protein eL34 family	rpl34e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02915	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34e
MMS1_k127_85296_33	1229909.NSED_01960	1.062e-41	160.0	COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMS1_k127_85296_61	420247.Msm_0733	4.44e-12	68.0	COG2163@1|root,arCOG04167@2157|Archaea,2XYTF@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL14 family	rpl14e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02875	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,Ribosomal_L14e
MMS1_k127_85296_14	387631.Asulf_01728	1.077e-90	317.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,245U4@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos
MMS1_k127_85296_0	589924.Ferp_1250	5.134e-290	927.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,246MU@183980|Archaeoglobi	183980|Archaeoglobi	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
MMS1_k127_85296_12	1056495.Calag_0699	8.643e-109	368.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPMC@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS1_k127_85296_63	573063.Metin_0422	9.105e-12	68.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,23R51@183939|Methanococci	183939|Methanococci	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMS1_k127_85296_47	1123376.AUIU01000012_gene1423	1.354e-28	124.0	COG0084@1|root,COG0535@1|root,COG0084@2|Bacteria,COG0535@2|Bacteria,3J0KM@40117|Nitrospirae	40117|Nitrospirae	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
MMS1_k127_85296_67	351607.Acel_2067	4.779e-11	75.0	arCOG03842@1|root,30WW9@2|Bacteria,2IDJ1@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF929
MMS1_k127_85296_16	273075.Ta0343	1.307e-89	304.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.20	ko:K01784,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
MMS1_k127_85296_68	515635.Dtur_0768	6.132e-11	69.0	COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria	2|Bacteria	P	C-terminal AAA-associated domain	abcT3	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS1_k127_85296_22	515635.Dtur_0768	1.86e-70	246.0	COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria	2|Bacteria	P	C-terminal AAA-associated domain	abcT3	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS1_k127_85296_29	1163730.FFONT_0375	3.839e-55	214.0	COG4986@1|root,arCOG00174@2157|Archaea,2XPPU@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
MMS1_k127_85296_18	868131.MSWAN_1447	4.03e-82	291.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,23NV1@183925|Methanobacteria	183925|Methanobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
MMS1_k127_85296_49	859653.HIMB5_00006800	2.106e-20	94.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,4BQ5Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	ada	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
MMS1_k127_85296_11	671065.MetMK1DRAFT_00025640	3.92e-112	371.0	arCOG06008@1|root,arCOG06008@2157|Archaea,2XRQ9@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_85296_59	386456.JQKN01000008_gene1364	5.588e-13	74.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota	28890|Euryarchaeota	K	Transcriptional regulator	nikR1	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
MMS1_k127_85296_2	592015.HMPREF1705_00165	1.755e-241	766.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes	508458|Synergistetes	G	PFAM glycosyl transferase family 20	-	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
MMS1_k127_85296_9	342949.PNA2_0859	2.446e-151	507.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,242Z2@183968|Thermococci	183968|Thermococci	L	DNA polymerase	pol	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1,Intein_splicing,LAGLIDADG_3
MMS1_k127_85296_25	604354.TSIB_1503	1.784e-59	216.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,242WX@183968|Thermococci	183968|Thermococci	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS1_k127_85296_36	113355.CM001775_gene2881	9.216e-40	153.0	COG1327@1|root,COG1327@2|Bacteria,1G5PE@1117|Cyanobacteria	1117|Cyanobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
MMS1_k127_85296_7	1123386.AUIW01000005_gene1549	2.708e-165	548.0	COG0209@1|root,COG0209@2|Bacteria,1WJ14@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
MMS1_k127_85296_45	351160.RCIX2744	6.663e-30	126.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,2NB98@224756|Methanomicrobia	224756|Methanomicrobia	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
MMS1_k127_85296_58	1229909.NSED_02965	3.665e-13	72.0	arCOG07473@1|root,arCOG07473@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_85296_19	374847.Kcr_1079	2.697e-78	274.0	COG0142@1|root,arCOG01726@2157|Archaea	2157|Archaea	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS1_k127_85296_43	269797.Mbar_A2985	3.251e-31	139.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0668 Small-conductance mechanosensitive channel	mscS1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMS1_k127_85296_60	1123355.JHYO01000001_gene3178	1.993e-12	73.0	COG1051@1|root,COG1051@2|Bacteria,1Q9DG@1224|Proteobacteria,2UK8P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS1_k127_85296_32	1128398.Curi_c15480	2.743e-42	170.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,267UQ@186813|unclassified Clostridiales	186801|Clostridia	S	Peptidase M16 inactive domain	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS1_k127_85296_30	1229909.NSED_08125	8.244e-51	191.0	COG0506@1|root,arCOG06322@2157|Archaea,41SY1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
MMS1_k127_85296_53	281687.CJA19624	2.662e-16	86.0	COG1011@1|root,COG3173@1|root,KOG1469@2759|Eukaryota,KOG3085@2759|Eukaryota,38BWX@33154|Opisthokonta,3BDYX@33208|Metazoa,3CUUN@33213|Bilateria,40FEJ@6231|Nematoda,1KXIP@119089|Chromadorea,40Z2G@6236|Rhabditida	33208|Metazoa	I	Acyl-CoA dehydrogenase, N-terminal domain	ACAD10	GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0031974,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	-	ko:K11729	-	-	-	-	ko00000	-	-	-	APH,Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,HAD_2,Hydrolase
MMS1_k127_85296_6	1131266.ARWQ01000011_gene105	2.487e-185	592.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMS1_k127_85296_39	330779.Saci_1335	7.841e-38	151.0	COG1407@1|root,arCOG01150@2157|Archaea,2XQJG@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
MMS1_k127_85296_1	1365176.N186_06220	4.788e-248	793.0	COG1201@1|root,arCOG00557@2157|Archaea,2XQ43@28889|Crenarchaeota	28889|Crenarchaeota	L	DEAD DEAH box helicase	-	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS1_k127_85296_48	203119.Cthe_1805	1.192e-25	121.0	COG2199@1|root,COG3706@2|Bacteria,1UHZ8@1239|Firmicutes,25E7W@186801|Clostridia,3WGN1@541000|Ruminococcaceae	186801|Clostridia	T	Diguanylate cyclase, GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
MMS1_k127_988529_20	647113.Metok_0824	6.173e-33	133.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,23QZ6@183939|Methanococci	183939|Methanococci	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMS1_k127_988529_23	868131.MSWAN_2343	1.389e-29	134.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,23NP1@183925|Methanobacteria	183925|Methanobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
MMS1_k127_988529_27	391623.TERMP_02121	5.867e-14	86.0	COG1287@1|root,arCOG02044@2157|Archaea,2XU59@28890|Euryarchaeota,242T3@183968|Thermococci	183968|Thermococci	M	Oligosaccharyl transferase, STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
MMS1_k127_988529_16	69014.TK1328	1.199e-38	152.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,2439X@183968|Thermococci	183968|Thermococci	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
MMS1_k127_988529_1	1343739.PAP_05975	4.008e-155	516.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,242TJ@183968|Thermococci	183968|Thermococci	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Topoisom_bac,Toprim,zf-C4_Topoisom
MMS1_k127_988529_28	1487923.DP73_03080	5.232e-12	70.0	COG2510@1|root,COG2510@2|Bacteria,1VFXX@1239|Firmicutes,24NK9@186801|Clostridia,262YK@186807|Peptococcaceae	186801|Clostridia	S	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_988529_31	1048834.TC41_1991	5.607e-07	57.0	COG2510@1|root,COG2510@2|Bacteria,1VFXX@1239|Firmicutes,4HQ8J@91061|Bacilli,27AA2@186823|Alicyclobacillaceae	91061|Bacilli	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS1_k127_988529_7	273116.14324833	2.039e-87	301.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7AD@28890|Euryarchaeota,24212@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_21
MMS1_k127_988529_18	490899.DKAM_0677	4.621e-38	156.0	COG0472@1|root,arCOG03199@2157|Archaea,2XPXP@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
MMS1_k127_988529_29	529709.PYCH_01310	1.94e-08	59.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
MMS1_k127_988529_6	272844.PAB0396	2.01e-96	329.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS1_k127_988529_3	391623.TERMP_01115	1.592e-120	400.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,243GJ@183968|Thermococci	183968|Thermococci	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMS1_k127_988529_19	1450694.BTS2_2929	6.023e-34	143.0	COG2267@1|root,COG2267@2|Bacteria,1TP59@1239|Firmicutes,4HBHV@91061|Bacilli,1ZSJG@1386|Bacillus	91061|Bacilli	I	Ndr family	yugF	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS1_k127_988529_24	289376.THEYE_A0515	7.59e-22	104.0	2DF6R@1|root,32U4T@2|Bacteria	2|Bacteria	L	TaqI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_TaqI
MMS1_k127_988529_11	397288.C806_01411	1.362e-52	196.0	COG2189@1|root,COG2189@2|Bacteria,1UHUQ@1239|Firmicutes,25E35@186801|Clostridia,27KYN@186928|unclassified Lachnospiraceae	186801|Clostridia	L	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS1_k127_988529_8	1459636.NTE_00289	2.295e-78	276.0	COG3039@1|root,arCOG02751@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
MMS1_k127_988529_10	399549.Msed_1011	8.269e-66	234.0	COG1968@1|root,arCOG04761@2157|Archaea,2XRRZ@28889|Crenarchaeota	28889|Crenarchaeota	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMS1_k127_988529_5	523850.TON_1414	5.977e-111	368.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,2433R@183968|Thermococci	183968|Thermococci	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,DNA_pol3_delta2,HTH_3,Intein_splicing,LAGLIDADG_3,Rep_fac_C,RuvB_N
MMS1_k127_988529_9	1209989.TepiRe1_0713	9.646e-78	277.0	COG1109@1|root,COG1109@2|Bacteria,1TS6S@1239|Firmicutes,2491F@186801|Clostridia,42FFK@68295|Thermoanaerobacterales	186801|Clostridia	G	alpha beta alpha domain I	manB	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS1_k127_988529_12	633148.Tagg_1395	1.041e-49	182.0	COG0100@1|root,arCOG04240@2157|Archaea,2XQCR@28889|Crenarchaeota	28889|Crenarchaeota	J	Located on the platform of the 30S subunit	rps11	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS1_k127_988529_17	195522.BD01_2186	2.744e-38	150.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,242UM@183968|Thermococci	183968|Thermococci	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
MMS1_k127_988529_21	272557.APE_1737.1	1.325e-31	130.0	COG0099@1|root,arCOG01722@2157|Archaea,2XQBF@28889|Crenarchaeota	28889|Crenarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMS1_k127_988529_2	1449080.JQMV01000003_gene890	3.086e-147	481.0	COG1190@1|root,COG1190@2|Bacteria,1WI4Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS1_k127_988529_13	1041930.Mtc_1898	1.66e-42	167.0	COG0095@1|root,arCOG01939@2157|Archaea,2XUJ0@28890|Euryarchaeota	28890|Euryarchaeota	H	COG0095 Lipoate-protein ligase A	lpl	GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901681	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS1_k127_988529_32	330779.Saci_2206	0.0001146	49.0	COG0095@1|root,arCOG01939@2157|Archaea,2XS85@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM Biotin lipoate A B protein ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_988529_22	572546.Arcpr_0880	5.435e-30	124.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,24688@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
MMS1_k127_988529_15	243232.MJ_0373	9.883e-41	156.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,23QV5@183939|Methanococci	183939|Methanococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS1_k127_988529_33	693661.Arcve_1550	0.0003748	51.0	COG0640@1|root,arCOG01683@2157|Archaea,2Y0SK@28890|Euryarchaeota,2476X@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS1_k127_988529_25	70601.3257411	6.338e-21	106.0	COG1041@1|root,arCOG00047@2157|Archaea,2Y2EJ@28890|Euryarchaeota,2432J@183968|Thermococci	183968|Thermococci	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
MMS1_k127_988529_30	436308.Nmar_1742	6.915e-08	55.0	arCOG07262@1|root,arCOG07262@2157|Archaea,41T8B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS1_k127_988529_4	933801.Ahos_0089	2.654e-118	404.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS1_k127_988529_0	273063.STK_24350	3.579e-254	797.0	COG0674@1|root,arCOG01606@2157|Archaea	2157|Archaea	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	korA	-	1.2.7.1,1.2.7.11,1.2.7.3	ko:K00169,ko:K00174	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00307,M00374,M00620	R01196,R01197,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS1_k127_988529_14	1121920.AUAU01000017_gene1221	9.126e-42	161.0	COG0605@1|root,COG0605@2|Bacteria	2|Bacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C
MMS1_k127_988529_26	403833.Pmob_1495	5.331e-18	91.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5,NinG
## 663 queries scanned
## Total time (seconds): 51.08681273460388
## Rate: 12.98 q/s