## Wed Feb 18 01:40:27 2026 ## emapper-2.1.13 ## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/MMS2_bin.46.fa -m mmseqs --output MMS2_bin.46 --output_dir /data/result/bins/wyx/eggqs50+/MMS2_bin.46 --itype genome --cpu 8 --override ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs MMS2_k127_1013757_0 1123261.AXDW01000006_gene2475 6.044e-93 316.0 COG0330@1|root,COG0330@2|Bacteria,1P392@1224|Proteobacteria,1RN26@1236|Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could regulate a protease hflC2 - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 MMS2_k127_1013757_1 1218075.BAYA01000005_gene2084 8.936e-51 194.0 COG0330@1|root,COG0330@2|Bacteria,1P8QE@1224|Proteobacteria,2W8C5@28216|Betaproteobacteria,1K3Z9@119060|Burkholderiaceae 28216|Betaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 MMS2_k127_1013757_2 205918.Psyr_5081 1.927e-11 72.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RQHN@1236|Gammaproteobacteria,1Z5TQ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria P P-type ATPase cadA - - - - - - - - - - - E1-E2_ATPase,Hydrolase MMS2_k127_1013935_1 1265502.KB905939_gene2402 4.491e-177 556.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VJXA@28216|Betaproteobacteria,4AB8B@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM amidohydrolase 2 - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 MMS2_k127_1013935_2 1265502.KB905939_gene2403 5.515e-119 387.0 COG1024@1|root,COG1024@2|Bacteria,1MWYZ@1224|Proteobacteria,2VJYU@28216|Betaproteobacteria,4AB6X@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.155 ko:K20036 ko00920,map00920 - R10936 RC00004,RC03306,RC03307 ko00000,ko00001,ko01000 - - - ECH_1 MMS2_k127_1013935_0 1158292.JPOE01000005_gene177 2.767e-212 681.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria,1KJUM@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme fcs - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding MMS2_k127_101895_0 713586.KB900536_gene2886 5.659e-231 722.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales 135613|Chromatiales T SMART Nucleotide binding protein, PINc - - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH MMS2_k127_101895_4 983917.RGE_08940 5.224e-62 221.0 COG1670@1|root,COG1670@2|Bacteria,1RKKE@1224|Proteobacteria,2VWB1@28216|Betaproteobacteria 28216|Betaproteobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 MMS2_k127_101895_2 396588.Tgr7_0823 2.028e-119 394.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales 135613|Chromatiales S AI-2E family transporter - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport MMS2_k127_101895_5 396588.Tgr7_0822 4.15e-32 130.0 2D186@1|root,32TA3@2|Bacteria,1N5ZE@1224|Proteobacteria,1S92Y@1236|Gammaproteobacteria,1WYYH@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_101895_3 1266908.AQPB01000046_gene2010 1.307e-98 344.0 COG0518@1|root,COG0518@2|Bacteria,1MYXC@1224|Proteobacteria,1SJVW@1236|Gammaproteobacteria 1236|Gammaproteobacteria F GMP synthase (glutamine-hydrolyzing) activity - - - - - - - - - - - - - MMS2_k127_101895_1 713586.KB900536_gene2882 1.048e-148 476.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WX6I@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_1030954_12 398527.Bphyt_1796 9.957e-64 222.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,1K1Y3@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA MMS2_k127_1030954_11 396588.Tgr7_0826 1.649e-69 241.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 MMS2_k127_1030954_4 519989.ECTPHS_00110 1.621e-135 436.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS MMS2_k127_1030954_14 713586.KB900536_gene2890 6.442e-45 177.0 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,1RZVF@1236|Gammaproteobacteria,1WXBS@135613|Chromatiales 135613|Chromatiales M NlpB/DapX lipoprotein - - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 MMS2_k127_1030954_8 713586.KB900536_gene2891 1.987e-98 327.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1X0P8@135613|Chromatiales 135613|Chromatiales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 MMS2_k127_1030954_18 768671.ThimaDRAFT_4422 7.177e-15 83.0 COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales 135613|Chromatiales L PFAM Transposase IS200 like - - - - - - - - - - - - HTH_23,Y1_Tnp MMS2_k127_1030954_16 1288826.MSNKSG1_14282 1.372e-27 116.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,4686H@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve MMS2_k127_1030954_19 393595.ABO_2081 2.621e-11 68.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1XI3W@135619|Oceanospirillales 135619|Oceanospirillales L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve MMS2_k127_1030954_20 644801.Psest_3412 4.593e-06 55.0 COG2963@1|root,COG2963@2|Bacteria,1MZ5C@1224|Proteobacteria,1S9KN@1236|Gammaproteobacteria,1Z37Y@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG2963 Transposase and inactivated derivatives - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 MMS2_k127_1030954_6 519989.ECTPHS_00120 1.459e-105 355.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales 135613|Chromatiales S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 MMS2_k127_1030954_13 1266909.AUAG01000019_gene423 2.551e-56 201.0 COG0720@1|root,COG0720@2|Bacteria,1PNDM@1224|Proteobacteria,1S7ZW@1236|Gammaproteobacteria,1WZ30@135613|Chromatiales 135613|Chromatiales H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS MMS2_k127_1030954_0 713586.KB900536_gene2894 1.241e-288 897.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales 135613|Chromatiales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C MMS2_k127_1030954_5 713586.KB900536_gene2895 4.88e-111 366.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt MMS2_k127_1030954_17 713586.KB900536_gene2896 1.232e-18 89.0 COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,1WYU7@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S MMS2_k127_1030954_9 713586.KB900536_gene2897 1.033e-79 267.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,1WXZP@135613|Chromatiales 135613|Chromatiales C PFAM Rubrerythrin - - - - - - - - - - - - Rubrerythrin MMS2_k127_1030954_1 713586.KB900536_gene2898 1.223e-245 764.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG MMS2_k127_1030954_10 2340.JV46_02690 6.518e-78 269.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1J9N9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 MMS2_k127_1030954_7 1121028.ARQE01000003_gene458 6.103e-102 349.0 COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,2PK7U@255475|Aurantimonadaceae 28211|Alphaproteobacteria S Phenazine biosynthesis-like protein - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF MMS2_k127_1030954_2 713586.KB900536_gene2913 5.719e-204 647.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales 135613|Chromatiales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C MMS2_k127_1030954_3 519989.ECTPHS_00150 1.38e-173 562.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales 135613|Chromatiales P CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 MMS2_k127_1030954_15 396588.Tgr7_0843 4.436e-39 149.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales 135613|Chromatiales S Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm MMS2_k127_1058937_0 1380394.JADL01000013_gene638 2.804e-112 377.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JVJ2@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 MMS2_k127_1058937_1 675635.Psed_6475 1.066e-58 211.0 COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4EAZ4@85010|Pseudonocardiales 201174|Actinobacteria C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 MMS2_k127_1058937_2 257310.BB0390 1.422e-29 123.0 COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VSFQ@28216|Betaproteobacteria,3T46Z@506|Alcaligenaceae 28216|Betaproteobacteria C CO dehydrogenase flavoprotein C-terminal domain - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 MMS2_k127_1086487_2 349521.HCH_06858 3.154e-203 647.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1XNU9@135619|Oceanospirillales 135619|Oceanospirillales H also known as acetolactate synthase large subunit - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N MMS2_k127_1086487_17 519989.ECTPHS_03734 1.659e-09 64.0 COG3978@1|root,COG3978@2|Bacteria 2|Bacteria S acetolactate synthase activity ilvM GO:0003674,GO:0003824,GO:0003984,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.2.1.6 ko:K01653,ko:K11258 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5 MMS2_k127_1086487_9 1158292.JPOE01000005_gene831 1.699e-84 300.0 COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,2WHCX@28216|Betaproteobacteria 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS,dCache_1 MMS2_k127_1086487_4 1158182.KB905022_gene1149 1.109e-186 610.0 COG0515@1|root,COG1639@1|root,COG0515@2|Bacteria,COG1639@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1X2AP@135613|Chromatiales 135613|Chromatiales T Protein tyrosine kinase - - - - - - - - - - - - GAF,HDOD,Pkinase MMS2_k127_1086487_13 713587.THITH_02020 4.799e-54 200.0 COG3751@1|root,COG3751@2|Bacteria,1RD3H@1224|Proteobacteria,1S40I@1236|Gammaproteobacteria,1WZ4N@135613|Chromatiales 135613|Chromatiales O 2OG-Fe(II) oxygenase superfamily - - - ko:K07394 - - - - ko00000 - - - 2OG-FeII_Oxy_3 MMS2_k127_1086487_10 1234364.AMSF01000025_gene3679 1.767e-80 271.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1X514@135614|Xanthomonadales 135614|Xanthomonadales S carbonic - - - - - - - - - - - - Hexapep MMS2_k127_1086487_12 1121271.AUCM01000005_gene781 1.639e-68 235.0 COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,2UC9I@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_1086487_16 1380387.JADM01000012_gene1478 1.202e-43 168.0 COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,1S6CS@1236|Gammaproteobacteria,1XKFJ@135619|Oceanospirillales 135619|Oceanospirillales C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB MMS2_k127_1086487_7 1392838.AWNM01000096_gene3075 7.819e-135 451.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,2VICI@28216|Betaproteobacteria,3T28G@506|Alcaligenaceae 28216|Betaproteobacteria K COG3284 Transcriptional activator of acetoin glycerol metabolism acoR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat MMS2_k127_1086487_0 471223.GWCH70_3145 1.59e-282 873.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,1WES5@129337|Geobacillus 91061|Bacilli C Belongs to the aldehyde dehydrogenase family acoD - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh MMS2_k127_1086487_3 454957.IA64_16300 1.037e-188 595.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1X4TA@135614|Xanthomonadales 135614|Xanthomonadales S alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS2_k127_1086487_15 1157708.KB907450_gene5183 5.384e-53 206.0 COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,2VSRW@28216|Betaproteobacteria,4AEPF@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF779) - - - ko:K09959 - - - - ko00000 - - - DUF779 MMS2_k127_1086487_6 765910.MARPU_00500 4.596e-170 544.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales 135613|Chromatiales E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N MMS2_k127_1086487_8 1382356.JQMP01000004_gene534 1.791e-94 324.0 COG0793@1|root,COG0793@2|Bacteria,2G6A8@200795|Chloroflexi,27Y0X@189775|Thermomicrobia 189775|Thermomicrobia M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,Peptidase_S41 MMS2_k127_1086487_5 396588.Tgr7_2759 7.752e-172 546.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C MMS2_k127_1086487_14 765910.MARPU_00870 3.831e-53 190.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,1WYGS@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H MMS2_k127_1086487_1 396588.Tgr7_2757 7.377e-221 692.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P MMS2_k127_1086487_11 765910.MARPU_00860 8.618e-71 243.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1WX7S@135613|Chromatiales 135613|Chromatiales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin MMS2_k127_1106298_2 519989.ECTPHS_09428 8.245e-83 297.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales 135613|Chromatiales M PFAM AsmA family protein - - - ko:K07289 - - - - ko00000 - - - AsmA MMS2_k127_1106298_1 870187.Thini_2985 9.697e-127 416.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,4625H@72273|Thiotrichales 72273|Thiotrichales S protein conserved in bacteria (DUF2333) - - - - - - - - - - - - DUF2333 MMS2_k127_1106298_4 713586.KB900536_gene1759 3.502e-22 101.0 COG0394@1|root,COG0394@2|Bacteria 2|Bacteria T Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - 1.20.4.1,2.8.4.2 ko:K03741,ko:K18701 - - - - ko00000,ko01000 - - - LMWPc MMS2_k127_1106298_3 1266909.AUAG01000029_gene1079 6.842e-47 175.0 COG0695@1|root,COG0695@2|Bacteria,1N0IY@1224|Proteobacteria,1SA4G@1236|Gammaproteobacteria,1X11H@135613|Chromatiales 135613|Chromatiales O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 MMS2_k127_1106298_0 1523503.JPMY01000017_gene2890 7.135e-129 416.0 COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,1RPYB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ycaQ - - ko:K09927 - - - - ko00000 - - - HTH_42 MMS2_k127_1110266_3 519989.ECTPHS_12983 3.116e-115 375.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine - - 2.4.2.28,2.4.2.44 ko:K00772,ko:K19696 ko00270,ko01100,map00270,map01100 M00034 R01402,R09668 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 MMS2_k127_1110266_9 765914.ThisiDRAFT_0456 1.799e-61 222.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1WWQX@135613|Chromatiales 135613|Chromatiales F phosphoribosyltransferase - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran MMS2_k127_1110266_8 1255043.TVNIR_1605 4.324e-67 230.0 COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,1SE6E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DsrE/DsrF-like family - - - - - - - - - - - - DrsE,DrsE_2 MMS2_k127_1110266_6 1123393.KB891332_gene2711 1.375e-85 309.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,1KRYA@119069|Hydrogenophilales 119069|Hydrogenophilales S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin MMS2_k127_1110266_0 1454004.AW11_01109 1.646e-140 456.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2VJCC@28216|Betaproteobacteria 28216|Betaproteobacteria M mechanosensitive ion channel ynaI - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel MMS2_k127_1110266_1 396588.Tgr7_1754 8.507e-140 452.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales 135613|Chromatiales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 MMS2_k127_1110266_7 94122.Shewana3_0540 5.185e-83 287.0 28M05@1|root,2ZB16@2|Bacteria,1QVZ0@1224|Proteobacteria,1T2NG@1236|Gammaproteobacteria,2QEST@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - YkuI_C MMS2_k127_1110266_5 395494.Galf_2854 3.857e-97 326.0 COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria 28216|Betaproteobacteria H PFAM UbiA prenyltransferase - - - - - - - - - - - - UbiA MMS2_k127_1110266_4 395494.Galf_2858 2.49e-111 377.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VJS8@28216|Betaproteobacteria 28216|Betaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 MMS2_k127_1110266_2 522306.CAP2UW1_1472 5.404e-139 477.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2VI37@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - ALO,FAD_binding_4 MMS2_k127_1110266_10 472759.Nhal_2172 1.738e-28 119.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,1S25V@1236|Gammaproteobacteria,1WZZS@135613|Chromatiales 135613|Chromatiales S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short MMS2_k127_111656_0 519989.ECTPHS_04708 2.387e-57 203.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,1RM9W@1236|Gammaproteobacteria,1WVYU@135613|Chromatiales 135613|Chromatiales N ATPase FliI YscN family - - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab MMS2_k127_111656_2 587753.EY04_07755 1.334e-12 73.0 COG2882@1|root,COG2882@2|Bacteria 2|Bacteria N bacterial-type flagellum organization fliJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02413 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliJ MMS2_k127_111656_3 640081.Dsui_1751 6.738e-11 74.0 COG3144@1|root,COG3144@2|Bacteria,1N7XT@1224|Proteobacteria,2VU2D@28216|Betaproteobacteria,2KX55@206389|Rhodocyclales 206389|Rhodocyclales N Flagellar hook-length control protein FliK - - - ko:K02414 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook MMS2_k127_111656_1 1249627.D779_2925 3.88e-20 101.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWT2@135613|Chromatiales 1236|Gammaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CZB,HAMP,MCPsignal,NIT,TarH MMS2_k127_1116578_7 519989.ECTPHS_02571 1.674e-28 119.0 COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,1S5K2@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 MMS2_k127_1116578_6 1163408.UU9_02873 7.93e-48 191.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1X6WU@135614|Xanthomonadales 135614|Xanthomonadales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 MMS2_k127_1116578_2 396588.Tgr7_0574 9.457e-160 511.0 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,1WXN5@135613|Chromatiales 135613|Chromatiales K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 MMS2_k127_1116578_0 396588.Tgr7_0575 6.281e-202 639.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,1WX7Y@135613|Chromatiales 135613|Chromatiales HJ Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - - - - - - - - - - ATP-grasp_3,RLAN,RimK MMS2_k127_1116578_5 1288826.MSNKSG1_04646 3.134e-75 259.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,466RY@72275|Alteromonadaceae 1236|Gammaproteobacteria S VIT family - - - - - - - - - - - - VIT1 MMS2_k127_1116578_3 637390.AFOH01000106_gene133 2.33e-116 388.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily ydgK - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 MMS2_k127_1116578_4 1279038.KB907340_gene1563 5.471e-90 307.0 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,2TW57@28211|Alphaproteobacteria,2JSI4@204441|Rhodospirillales 204441|Rhodospirillales S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE MMS2_k127_1116578_1 177437.HRM2_28390 1.174e-162 518.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,42MTV@68525|delta/epsilon subdivisions,2WKVP@28221|Deltaproteobacteria,2MMZI@213118|Desulfobacterales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF853) - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 MMS2_k127_1130937_8 314278.NB231_03962 4.422e-127 431.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1WX8M@135613|Chromatiales 135613|Chromatiales NU Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC MMS2_k127_1130937_20 267608.RSp1287 4.096e-24 109.0 COG4968@1|root,COG4968@2|Bacteria,1MZUI@1224|Proteobacteria,2VVCM@28216|Betaproteobacteria,1K7UZ@119060|Burkholderiaceae 28216|Betaproteobacteria NU Type IV minor pilin ComP, DNA uptake sequence receptor - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl MMS2_k127_1130937_6 1395516.PMO01_23235 6.041e-153 489.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024 LYTB MMS2_k127_1130937_19 1397528.Q671_10880 1.662e-31 128.0 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria,1XKIV@135619|Oceanospirillales 135619|Oceanospirillales O Peptidyl-prolyl cis-trans fkpB - 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C MMS2_k127_1130937_9 1234364.AMSF01000007_gene469 4.556e-113 368.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1X457@135614|Xanthomonadales 135614|Xanthomonadales O C-terminal domain of 1-Cys peroxiredoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA MMS2_k127_1130937_13 396588.Tgr7_3056 4.151e-64 228.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1X0SA@135613|Chromatiales 135613|Chromatiales D Cellulose biosynthesis protein BcsQ - - - - - - - - - - - - AAA_31 MMS2_k127_1130937_2 396588.Tgr7_3057 8.032e-253 794.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding MMS2_k127_1130937_17 396588.Tgr7_3058 3.091e-36 141.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria 1224|Proteobacteria I Acyl-CoA hydrolase yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT MMS2_k127_1130937_16 29581.BW37_04046 3.456e-41 161.0 COG1309@1|root,COG1309@2|Bacteria,1RCC8@1224|Proteobacteria 1224|Proteobacteria K PFAM regulatory protein TetR - - - - - - - - - - - - TetR_N MMS2_k127_1130937_1 1123073.KB899241_gene1957 6.002e-256 813.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1X333@135614|Xanthomonadales 135614|Xanthomonadales I converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974 MMS2_k127_1130937_0 187272.Mlg_2126 2.043e-276 873.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ACBP,ECH_1 MMS2_k127_1130937_4 1384054.N790_00645 1.201e-171 546.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X32A@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N MMS2_k127_1130937_3 522306.CAP2UW1_3331 3.115e-222 704.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1KQ8E@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C MMS2_k127_1130937_18 713586.KB900536_gene1883 1.878e-34 138.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria 1224|Proteobacteria I Acyl-CoA hydrolase yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT MMS2_k127_1130937_10 211165.AJLN01000078_gene413 9.403e-100 342.0 COG2067@1|root,COG2067@2|Bacteria,1GBW9@1117|Cyanobacteria,1JJ8V@1189|Stigonemataceae 1117|Cyanobacteria I Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X MMS2_k127_1130937_11 1123261.AXDW01000002_gene1562 1.118e-99 338.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1X33P@135614|Xanthomonadales 135614|Xanthomonadales C Quinone oxidoreductase - - - - - - - - - - - - ADH_N,ADH_zinc_N MMS2_k127_1130937_14 391615.ABSJ01000035_gene994 1.921e-54 198.0 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,1JB4Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - DUF4124,SLT MMS2_k127_1130937_12 396588.Tgr7_0265 4.718e-90 304.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,1SZRM@1236|Gammaproteobacteria,1WWZE@135613|Chromatiales 135613|Chromatiales S Molybdopterin binding - - - - - - - - - - - - MoCF_biosynth MMS2_k127_1130937_15 717773.Thicy_0028 3.09e-44 169.0 29D2R@1|root,3000T@2|Bacteria,1RG31@1224|Proteobacteria,1SNCY@1236|Gammaproteobacteria,462C0@72273|Thiotrichales 72273|Thiotrichales - - - - - ko:K06910 - - - - ko00000 - - - - MMS2_k127_1130937_5 765913.ThidrDRAFT_1695 2.249e-169 536.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,1RNFF@1236|Gammaproteobacteria,1WXJM@135613|Chromatiales 135613|Chromatiales G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp - 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase MMS2_k127_1130937_7 765914.ThisiDRAFT_2758 6.749e-151 487.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK MMS2_k127_1151525_4 1033802.SSPSH_000074 4.388e-52 188.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - ko:K05524 - - - - ko00000 - - - DUF1971,DUF3470,Fer4 MMS2_k127_1151525_1 519989.ECTPHS_12398 0.0 1131.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales 135613|Chromatiales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V MMS2_k127_1151525_5 634499.EpC_27950 8.071e-52 190.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,3X651@551|Erwinia 1236|Gammaproteobacteria S Belongs to the CinA family ygaD GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA MMS2_k127_1151525_8 713587.THITH_06165 1.47e-25 117.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1WZ3C@135613|Chromatiales 135613|Chromatiales J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase MMS2_k127_1151525_3 713586.KB900536_gene30 1.276e-187 590.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1WW13@135613|Chromatiales 135613|Chromatiales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA MMS2_k127_1151525_7 305900.GV64_15915 7.768e-26 112.0 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1XM17@135619|Oceanospirillales 135619|Oceanospirillales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX MMS2_k127_1151525_0 396588.Tgr7_1289 0.0 1210.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD MMS2_k127_1151525_2 396588.Tgr7_1290 3.073e-199 627.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales 135613|Chromatiales E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 MMS2_k127_1151525_9 1335757.SPICUR_04060 1.036e-22 101.0 COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria 1224|Proteobacteria J Could accelerate the degradation of some genes transcripts potentially through selective RNA binding csrA - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA MMS2_k127_1151525_10 1247024.JRLH01000006_gene2694 7.082e-05 53.0 2DR0Q@1|root,339PT@2|Bacteria,1NM26@1224|Proteobacteria,1SJC7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1151525_6 765914.ThisiDRAFT_1638 1.291e-42 162.0 COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,1RY54@1236|Gammaproteobacteria,1WWFU@135613|Chromatiales 135613|Chromatiales O peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase MMS2_k127_1152522_2 396588.Tgr7_0981 6.35e-290 895.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales 135613|Chromatiales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 MMS2_k127_1152522_11 1123401.JHYQ01000005_gene288 1.768e-78 267.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,460FZ@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ MMS2_k127_1152522_22 765910.MARPU_08360 1.242e-21 98.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1WYSK@135613|Chromatiales 135613|Chromatiales J CRS1_YhbY - - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY MMS2_k127_1152522_12 396588.Tgr7_0978 6.914e-74 254.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N MMS2_k127_1152522_0 713586.KB900536_gene3035 0.0 1705.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales 135613|Chromatiales EF Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS MMS2_k127_1152522_3 243233.MCA1853 3.522e-185 586.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XERV@135618|Methylococcales 135618|Methylococcales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase MMS2_k127_1152522_7 396588.Tgr7_0974 1.597e-122 398.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N MMS2_k127_1152522_21 90814.KL370891_gene556 3.864e-42 162.0 COG1416@1|root,COG1416@2|Bacteria,1N0U1@1224|Proteobacteria,1SGKY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE MMS2_k127_1152522_4 1158146.KB907122_gene498 1.054e-181 576.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1WWEM@135613|Chromatiales 135613|Chromatiales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG MMS2_k127_1152522_1 713586.KB900536_gene3031 0.0 1044.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 MMS2_k127_1152522_16 713586.KB900536_gene3030 7.019e-58 207.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales 135613|Chromatiales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE MMS2_k127_1152522_8 519989.ECTPHS_06962 3.489e-122 401.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg MMS2_k127_1152522_9 713586.KB900536_gene3028 2.657e-95 322.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales 135613|Chromatiales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase MMS2_k127_1152522_5 396588.Tgr7_0968 5.088e-164 533.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N MMS2_k127_1152522_15 713586.KB900536_gene3026 3.868e-64 223.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,1WYAR@135613|Chromatiales 135613|Chromatiales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR MMS2_k127_1152522_24 1437882.AZRU01000037_gene4367 5.288e-19 91.0 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,1SCTT@1236|Gammaproteobacteria,1YG1W@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0030674,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042221,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0045229,GO:0046677,GO:0050896,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0060090,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA MMS2_k127_1152522_23 713587.THITH_13160 4.927e-21 101.0 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1WZ6P@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0125 (RnfH) family - - - ko:K09801 - - - - ko00000 - - - Ub-RnfH MMS2_k127_1152522_17 472759.Nhal_0885 2.473e-57 206.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1WY06@135613|Chromatiales 135613|Chromatiales I Cyclase dehydrase - - - - - - - - - - - - Polyketide_cyc MMS2_k127_1152522_6 519989.ECTPHS_06927 4.392e-156 505.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF MMS2_k127_1152522_13 713586.KB900536_gene3021 1.584e-68 239.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales 135613|Chromatiales O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB MMS2_k127_1152522_10 1123279.ATUS01000001_gene682 9.319e-94 313.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1J4T2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 ko:K02342,ko:K14159 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_H,RNase_T MMS2_k127_1152522_20 1150621.SMUL_1032 1.083e-43 167.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,42QQY@68525|delta/epsilon subdivisions,2YRUS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E LysE type translocator - - - - - - - - - - - - LysE MMS2_k127_1152522_14 1123401.JHYQ01000027_gene3114 1.751e-68 236.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,460RH@72273|Thiotrichales 72273|Thiotrichales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H MMS2_k127_1152522_19 396588.Tgr7_0954 6.045e-49 186.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 MMS2_k127_1152522_18 713586.KB900536_gene3005 2.753e-53 198.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1WXD7@135613|Chromatiales 135613|Chromatiales M lytic transglycosylase - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT MMS2_k127_1194492_23 396588.Tgr7_1283 7.796e-09 57.0 COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1WYG0@135613|Chromatiales 135613|Chromatiales N Host attachment protein - - - - - - - - - - - - Host_attach MMS2_k127_1194492_15 1237149.C900_01127 1.024e-42 162.0 COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,47R7I@768503|Cytophagia 976|Bacteroidetes T PFAM Phosphoglycerate mutase sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 MMS2_k127_1194492_1 713586.KB900536_gene1551 5.286e-250 783.0 COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,1RMGK@1236|Gammaproteobacteria,1WWHA@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine - - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS2_k127_1194492_19 314278.NB231_00345 4.926e-25 110.0 2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,1S9DD@1236|Gammaproteobacteria,1WYZ8@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF1992) - - - - - - - - - - - - DUF1992 MMS2_k127_1194492_7 1232410.KI421412_gene177 5.738e-119 388.0 COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,42YTV@68525|delta/epsilon subdivisions,2WTY1@28221|Deltaproteobacteria,43TGH@69541|Desulfuromonadales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - ko:K13775 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short MMS2_k127_1194492_3 713586.KB900536_gene165 1.077e-157 508.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr MMS2_k127_1194492_6 519989.ECTPHS_08418 1.521e-127 412.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria 1236|Gammaproteobacteria L 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 MMS2_k127_1194492_4 396588.Tgr7_1100 2.824e-154 498.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1WX3I@135613|Chromatiales 135613|Chromatiales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS2_k127_1194492_17 187272.Mlg_1351 1.003e-32 134.0 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1WZIU@135613|Chromatiales 135613|Chromatiales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS MMS2_k127_1194492_12 349124.Hhal_0031 5.073e-84 291.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales 135613|Chromatiales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ MMS2_k127_1194492_16 579405.Dd703_2783 8.357e-41 164.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,2JCYU@204037|Dickeya 1236|Gammaproteobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N MMS2_k127_1194492_10 930169.B5T_01539 3.598e-91 317.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XHGU@135619|Oceanospirillales 135619|Oceanospirillales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 MMS2_k127_1194492_13 1122201.AUAZ01000003_gene2010 3.363e-69 242.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,466PY@72275|Alteromonadaceae 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm MMS2_k127_1194492_22 105559.Nwat_0675 7.358e-13 74.0 COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1WYXD@135613|Chromatiales 135613|Chromatiales NU Domain of unknown function (DUF4845) - - - - - - - - - - - - DUF4845 MMS2_k127_1194492_9 519989.ECTPHS_08368 5.623e-95 319.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1WXAU@135613|Chromatiales 135613|Chromatiales U Belongs to the peptidase S26 family - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 MMS2_k127_1194492_0 519989.ECTPHS_08363 6.871e-316 975.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales 135613|Chromatiales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C MMS2_k127_1194492_20 519989.ECTPHS_08353 2.002e-24 104.0 COG3118@1|root,COG3118@2|Bacteria,1NIQX@1224|Proteobacteria 1224|Proteobacteria O Glutaredoxin-like domain (DUF836) - - - - - - - - - - - - DUF836 MMS2_k127_1194492_14 765914.ThisiDRAFT_1137 1.092e-47 183.0 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales 135613|Chromatiales T PFAM MucB RseB - - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C MMS2_k127_1194492_18 765914.ThisiDRAFT_1138 3.222e-27 118.0 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SGPC@1236|Gammaproteobacteria,1WYNC@135613|Chromatiales 135613|Chromatiales T PFAM Anti sigma-E protein RseA - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N MMS2_k127_1194492_11 396588.Tgr7_1083 8.056e-91 302.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1WXBZ@135613|Chromatiales 135613|Chromatiales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 MMS2_k127_1194492_2 870187.Thini_0638 2.18e-229 723.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,46098@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C MMS2_k127_1194492_8 472759.Nhal_2649 3.449e-98 330.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WYU5@135613|Chromatiales 135613|Chromatiales P PFAM Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese MMS2_k127_1194492_21 1232683.ADIMK_2539 1.554e-16 92.0 COG0680@1|root,COG0680@2|Bacteria 2|Bacteria C spore germination hoxW - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI MMS2_k127_1194492_5 743299.Acife_1821 2.626e-135 437.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria,2NCF3@225057|Acidithiobacillales 225057|Acidithiobacillales C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases MMS2_k127_1201023_0 2340.JV46_04780 8.734e-145 469.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD MMS2_k127_1201023_3 243159.AFE_3098 7.065e-09 63.0 2C6PQ@1|root,2ZN4I@2|Bacteria,1PAJA@1224|Proteobacteria,1SWBC@1236|Gammaproteobacteria,2NDYY@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_1201023_2 349124.Hhal_0173 6.744e-95 342.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF MMS2_k127_1201023_1 1304883.KI912532_gene2702 3.671e-117 384.0 COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,2WEGM@28216|Betaproteobacteria,2KZV8@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD_5 MMS2_k127_1214338_3 1396418.BATQ01000142_gene3264 1.508e-05 51.0 2DG6B@1|root,2ZUQ3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS2_k127_1214338_0 1288826.MSNKSG1_14037 1.81e-78 273.0 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,1RNSM@1236|Gammaproteobacteria,466Y1@72275|Alteromonadaceae 1236|Gammaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily pagO - - - - - - - - - - - EamA MMS2_k127_1214338_1 225937.HP15_2741 1.77e-76 267.0 COG4977@1|root,COG4977@2|Bacteria,1MXZQ@1224|Proteobacteria,1RQM6@1236|Gammaproteobacteria,4695Z@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2207 AraC-type DNA-binding domain-containing proteins tetD - - ko:K07506 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18,HTH_AraC MMS2_k127_1214338_2 1255043.TVNIR_0941 2.105e-14 75.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S5IM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B MMS2_k127_1224898_11 1288826.MSNKSG1_13962 1.044e-138 447.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,464KF@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed - - - - - - - - - - - - Thiolase_C,Thiolase_N MMS2_k127_1224898_34 1397528.Q671_07770 2.505e-15 89.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RSEV@1236|Gammaproteobacteria,1XNUC@135619|Oceanospirillales 135619|Oceanospirillales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N MMS2_k127_1224898_3 1288826.MSNKSG1_13967 3.766e-212 670.0 COG0624@1|root,COG0624@2|Bacteria,1MW2W@1224|Proteobacteria,1S1T9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 MMS2_k127_1224898_26 1122201.AUAZ01000018_gene1711 1.41e-75 263.0 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,1S35C@1236|Gammaproteobacteria,46DH3@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit - - - - - - - - - - - - CoA_trans MMS2_k127_1224898_17 1288826.MSNKSG1_13977 6.713e-110 359.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,4644U@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit atoD - 2.8.3.5,2.8.3.8,2.8.3.9 ko:K01028,ko:K01034 ko00072,ko00280,ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00627,map00640,map00650,map01100,map01120,map02020 - R00410,R01179,R01359,R01365,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans MMS2_k127_1224898_12 1121940.AUDZ01000005_gene2050 4.46e-133 430.0 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,1RPHN@1236|Gammaproteobacteria,1XH7H@135619|Oceanospirillales 135619|Oceanospirillales K Transcriptional regulator, LysR - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_1224898_13 570967.JMLV01000003_gene2099 6.576e-121 394.0 COG1176@1|root,COG1176@2|Bacteria,1MVFG@1224|Proteobacteria,2TSSR@28211|Alphaproteobacteria,2JQC0@204441|Rhodospirillales 204441|Rhodospirillales E Binding-protein-dependent transport system inner membrane component - - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 MMS2_k127_1224898_16 384765.SIAM614_06753 2.152e-115 377.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2VF9H@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type spermidine putrescine transport system, permease component II - - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 MMS2_k127_1224898_4 1089552.KI911559_gene1042 1.107e-181 575.0 COG0687@1|root,COG0687@2|Bacteria,1Q2AN@1224|Proteobacteria,2U1XB@28211|Alphaproteobacteria,2JPMA@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding protein - - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 MMS2_k127_1224898_10 1089552.KI911559_gene1041 1.131e-139 454.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JRK4@204441|Rhodospirillales 204441|Rhodospirillales E TOBE domain - - - - - - - - - - - - ABC_tran,TOBE_2 MMS2_k127_1224898_7 1121943.KB899994_gene1083 1.894e-153 495.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1S070@1236|Gammaproteobacteria 1236|Gammaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl MMS2_k127_1224898_29 270374.MELB17_10403 7.108e-51 187.0 COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,1S5WM@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Translation Initiation Inhibitor YjgF Family yoaB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Ribonuc_L-PSP MMS2_k127_1224898_9 768066.HELO_2879 2.025e-141 455.0 COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,1RNFV@1236|Gammaproteobacteria,1XIU1@135619|Oceanospirillales 135619|Oceanospirillales E ornithine cyclodeaminase - - 1.5.1.49,4.3.1.12 ko:K01750,ko:K19742 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671,R01246,R01249 RC00135,RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall MMS2_k127_1224898_30 358220.C380_15430 2.147e-47 191.0 COG2199@1|root,COG3706@2|Bacteria,1MVME@1224|Proteobacteria,2WEF3@28216|Betaproteobacteria,4ADFW@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF MMS2_k127_1224898_24 1234364.AMSF01000087_gene2795 1.064e-91 304.0 COG0586@1|root,COG0586@2|Bacteria,1RGII@1224|Proteobacteria,1S844@1236|Gammaproteobacteria,1XCVR@135614|Xanthomonadales 135614|Xanthomonadales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc MMS2_k127_1224898_22 158500.BV97_03786 4.307e-100 334.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,2K0DM@204457|Sphingomonadales 28211|Alphaproteobacteria Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - - - - - - - - - - DUF2437,FAA_hydrolase MMS2_k127_1224898_28 75379.Tint_2859 3.111e-56 200.0 COG3431@1|root,COG3431@2|Bacteria,1N7CX@1224|Proteobacteria,2WFFX@28216|Betaproteobacteria 28216|Betaproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE MMS2_k127_1224898_0 630626.EBL_c25860 8.865e-273 853.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPN9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains ybiT GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0050896 - - - - - - - - - - ABC_tran,ABC_tran_Xtn MMS2_k127_1224898_33 565045.NOR51B_2137 4.299e-24 104.0 COG2827@1|root,COG2827@2|Bacteria 2|Bacteria L Endonuclease containing a URI domain yhbQ GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07461 - - - - ko00000 - - - GIY-YIG MMS2_k127_1224898_18 637390.AFOH01000110_gene2860 8.169e-110 368.0 COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,1RNTS@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057,ko:K10440 ko02010,map02010 M00212,M00221 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 MMS2_k127_1224898_21 637390.AFOH01000110_gene2859 6.528e-101 334.0 COG1129@1|root,COG1129@2|Bacteria,1MVNR@1224|Proteobacteria,1RY9K@1236|Gammaproteobacteria 1236|Gammaproteobacteria G (ABC) transporter - - 3.6.3.17 ko:K02056,ko:K10544,ko:K10545 ko02010,map02010 M00215,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.4 - - ABC_tran MMS2_k127_1224898_25 637390.AFOH01000110_gene2858 4.58e-86 294.0 COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,1RPBV@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Periplasmic rbsB - - ko:K10439,ko:K10549 ko02010,ko02030,map02010,map02030 M00212,M00217 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.6 - - Peripla_BP_4 MMS2_k127_1224898_27 349163.Acry_2877 1.236e-72 263.0 COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2UA3V@28211|Alphaproteobacteria,2JWUT@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB MMS2_k127_1224898_23 1408419.JHYG01000005_gene477 5.361e-97 327.0 COG1609@1|root,COG1609@2|Bacteria,1MU1G@1224|Proteobacteria,2U5RR@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 MMS2_k127_1224898_2 396588.Tgr7_0903 5.558e-225 705.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1WW9J@135613|Chromatiales 135613|Chromatiales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt MMS2_k127_1224898_8 396588.Tgr7_0902 1.176e-144 469.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales 135613|Chromatiales E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His MMS2_k127_1224898_35 1453503.AU05_24370 4.171e-13 72.0 COG3242@1|root,COG3242@2|Bacteria,1N9FC@1224|Proteobacteria,1SEP6@1236|Gammaproteobacteria,1YK34@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2065) - - - ko:K09937 - - - - ko00000 - - - DUF2065 MMS2_k127_1224898_20 396588.Tgr7_0900 1.721e-101 340.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1WW0U@135613|Chromatiales 135613|Chromatiales O HflC and HflK could regulate a protease - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 MMS2_k127_1224898_15 765914.ThisiDRAFT_0367 1.033e-117 391.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1WWWJ@135613|Chromatiales 135613|Chromatiales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N MMS2_k127_1224898_5 1122201.AUAZ01000021_gene3194 8.653e-160 514.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,464MZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 MMS2_k127_1224898_32 305900.GV64_03905 5.084e-35 136.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1XKET@135619|Oceanospirillales 135619|Oceanospirillales J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq MMS2_k127_1224898_19 396588.Tgr7_0896 8.129e-109 387.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1WWI0@135613|Chromatiales 135613|Chromatiales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT MMS2_k127_1224898_1 713586.KB900536_gene2956 3.644e-242 764.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1WWKZ@135613|Chromatiales 135613|Chromatiales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C MMS2_k127_1224898_14 396588.Tgr7_0894 8.315e-118 392.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales 135613|Chromatiales M Cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM MMS2_k127_1224898_31 500637.PROVRUST_06521 6.548e-47 174.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,3Z7J9@586|Providencia 1236|Gammaproteobacteria S Hydrolase, P-loop family yjeE GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K06925 - - - - ko00000,ko03016 - - - TsaE MMS2_k127_1224898_6 765910.MARPU_07205 3.395e-154 503.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N MMS2_k127_1242697_4 927677.ALVU02000008_gene20 1.898e-23 111.0 COG0037@1|root,COG0037@2|Bacteria 2|Bacteria D tRNA processing tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,Condensation,TilS,TilS_C MMS2_k127_1242697_3 83406.HDN1F_11040 1.468e-64 233.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1SYQK@1236|Gammaproteobacteria,1JAPP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase MMS2_k127_1242697_0 396588.Tgr7_2159 2.974e-214 677.0 COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,1SMP4@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity - - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V MMS2_k127_1242697_1 396588.Tgr7_2160 3.274e-191 603.0 COG0667@1|root,COG0667@2|Bacteria,1RK6Z@1224|Proteobacteria,1SKN5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red MMS2_k127_1242697_2 396588.Tgr7_2162 6.554e-119 388.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales 135613|Chromatiales BQ PFAM histone deacetylase superfamily - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl MMS2_k127_1322742_1 765914.ThisiDRAFT_2078 5.8e-166 532.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales 135613|Chromatiales U sulphate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp MMS2_k127_1322742_0 1297742.A176_05808 4.904e-302 936.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2Z30F@29|Myxococcales 28221|Deltaproteobacteria I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C MMS2_k127_1322742_2 396588.Tgr7_1510 8.746e-83 280.0 COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,1RYXQ@1236|Gammaproteobacteria,1WX88@135613|Chromatiales 135613|Chromatiales K GntR family - - - - - - - - - - - - FCD,GntR MMS2_k127_1322742_3 998674.ATTE01000001_gene1109 6.233e-49 177.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,46076@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase MMS2_k127_1325898_8 713586.KB900536_gene1733 1.56e-28 115.0 COG1522@1|root,COG1522@2|Bacteria,1RG35@1224|Proteobacteria,1S484@1236|Gammaproteobacteria,1X0PR@135613|Chromatiales 135613|Chromatiales K M protein trans-acting positive regulator (MGA) HTH domain - - - - - - - - - - - - AsnC_trans_reg,HTH_24 MMS2_k127_1325898_4 349521.HCH_01388 1.047e-101 335.0 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1XJGU@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate - - 4.1.99.12 ko:K02858 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R07281 RC01792,RC01815 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase MMS2_k127_1325898_9 246200.SPO0268 2.065e-10 65.0 COG0054@1|root,COG0054@2|Bacteria,1RHCZ@1224|Proteobacteria,2U5EC@28211|Alphaproteobacteria,4NBYE@97050|Ruegeria 28211|Alphaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH2 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase MMS2_k127_1325898_1 1408418.JNJH01000024_gene36 3.469e-126 413.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,2JRX6@204441|Rhodospirillales 204441|Rhodospirillales F Inosine-uridine preferring nucleoside hydrolase - - 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro MMS2_k127_1325898_0 380394.Lferr_1067 3.151e-144 471.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh MMS2_k127_1325898_2 426114.THI_2723 3.259e-122 409.0 COG2303@1|root,COG2303@2|Bacteria 2|Bacteria E choline dehydrogenase activity - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 MMS2_k127_1325898_7 1380387.JADM01000004_gene2862 6.384e-30 121.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XM5A@135619|Oceanospirillales 135619|Oceanospirillales K cold-shock protein cspG - - ko:K03704 - - - - ko00000,ko03000 - - - CSD MMS2_k127_1325898_10 1234364.AMSF01000005_gene799 7.396e-05 53.0 COG3678@1|root,COG3678@2|Bacteria,1RBDH@1224|Proteobacteria,1SXBX@1236|Gammaproteobacteria,1X898@135614|Xanthomonadales 135614|Xanthomonadales NPTU LTXXQ motif family protein - - - - - - - - - - - - LTXXQ MMS2_k127_1325898_6 1283284.AZUK01000001_gene2345 4.485e-85 287.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMW7@1236|Gammaproteobacteria,1Y5HW@135624|Aeromonadales 135624|Aeromonadales K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain cpxR - - ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C MMS2_k127_1325898_3 265072.Mfla_0715 4.157e-108 367.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1N17V@1224|Proteobacteria,2WEJE@28216|Betaproteobacteria,2KNQG@206350|Nitrosomonadales 206350|Nitrosomonadales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA MMS2_k127_1325898_5 1123279.ATUS01000002_gene17 9.468e-87 291.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1J4WH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0514 Superfamily II DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind MMS2_k127_1326868_1 420662.Mpe_A0313 4.026e-52 192.0 COG1131@1|root,COG1131@2|Bacteria,1MY19@1224|Proteobacteria,2VJ5R@28216|Betaproteobacteria 28216|Betaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_1326868_2 443143.GM18_1315 2.08e-44 183.0 2AEFS@1|root,314AU@2|Bacteria,1RKTV@1224|Proteobacteria,42YDD@68525|delta/epsilon subdivisions,2WUI4@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1326868_0 572477.Alvin_0800 1.591e-65 229.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase MMS2_k127_1336426_6 95619.PM1_0206095 3.174e-48 174.0 COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,1S7S7@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 MMS2_k127_1336426_3 1156919.QWC_10931 1.281e-59 213.0 COG1280@1|root,COG1280@2|Bacteria,1REQX@1224|Proteobacteria,2VSUF@28216|Betaproteobacteria,3T7MI@506|Alcaligenaceae 28216|Betaproteobacteria E Lysine transporter LysE - - - - - - - - - - - - LysE MMS2_k127_1336426_2 519989.ECTPHS_09418 4.104e-67 232.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1WY7V@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC MMS2_k127_1336426_9 713586.KB900536_gene1761 1.719e-25 108.0 COG1977@1|root,COG1977@2|Bacteria,1NHG7@1224|Proteobacteria,1TK6F@1236|Gammaproteobacteria,1WZUM@135613|Chromatiales 135613|Chromatiales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS MMS2_k127_1336426_5 396588.Tgr7_2952 1.379e-55 198.0 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1WYCE@135613|Chromatiales 135613|Chromatiales H PFAM molybdopterin biosynthesis MoaE - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE MMS2_k127_1336426_0 396588.Tgr7_2956 1.718e-127 414.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1WX0B@135613|Chromatiales 135613|Chromatiales O heat shock protein DnaJ - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C MMS2_k127_1336426_4 396588.Tgr7_2957 5.923e-59 207.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1WYTK@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 MMS2_k127_1336426_8 187272.Mlg_2431 2.6e-30 126.0 2E35S@1|root,32Y5P@2|Bacteria,1N6WS@1224|Proteobacteria,1SD5T@1236|Gammaproteobacteria,1X269@135613|Chromatiales 135613|Chromatiales S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 MMS2_k127_1336426_1 713586.KB900536_gene1767 9.893e-103 342.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales 135613|Chromatiales S PFAM YicC-like - - - - - - - - - - - - DUF1732,YicC_N MMS2_k127_1336426_7 377629.TERTU_0176 1.943e-34 133.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,2PNAR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J 3' exoribonuclease family, domain 2 rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C MMS2_k127_1380262_3 395961.Cyan7425_1964 7.834e-45 168.0 COG2071@1|root,COG2071@2|Bacteria,1G5CB@1117|Cyanobacteria 1117|Cyanobacteria S PFAM Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 MMS2_k127_1380262_2 1120792.JAFV01000001_gene2633 2.584e-159 515.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,36ZCT@31993|Methylocystaceae 28211|Alphaproteobacteria C Iron-containing alcohol dehydrogenase mdh1 - 1.1.1.1,1.1.1.61 ko:K00001,ko:K00043 ko00010,ko00071,ko00350,ko00625,ko00626,ko00650,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00010,map00071,map00350,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220 - R00623,R00754,R01644,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH MMS2_k127_1380262_1 526227.Mesil_3300 3.427e-194 617.0 COG1012@1|root,COG1012@2|Bacteria,1WK1N@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS2_k127_1380262_0 42256.RradSPS_2751 4.921e-226 705.0 COG0174@1|root,COG0174@2|Bacteria,2GM3K@201174|Actinobacteria,4CPBS@84995|Rubrobacteria 84995|Rubrobacteria E PFAM glutamine synthetase catalytic region - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C MMS2_k127_1411607_3 189753.AXAS01000010_gene7423 2.299e-38 145.0 COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,2TU0H@28211|Alphaproteobacteria,3JUEJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD MMS2_k127_1411607_2 1205680.CAKO01000002_gene2296 9.184e-56 198.0 COG0454@1|root,COG0456@2|Bacteria,1N506@1224|Proteobacteria,2TWEW@28211|Alphaproteobacteria,2JUWU@204441|Rhodospirillales 204441|Rhodospirillales K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_1411607_1 1205680.CAKO01000002_gene2297 1.253e-67 245.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U63R@28211|Alphaproteobacteria,2JSDE@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity - - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 MMS2_k127_1411607_0 1163617.SCD_n02853 2.444e-157 508.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK MMS2_k127_1411607_4 1415630.U771_24980 8.227e-16 85.0 COG3795@1|root,COG3795@2|Bacteria,1MZ5E@1224|Proteobacteria,1SYEJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII MMS2_k127_1415065_4 395493.BegalDRAFT_0491 3.721e-15 81.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,4623J@72273|Thiotrichales 72273|Thiotrichales C formate dehydrogenase - - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB MMS2_k127_1415065_2 472759.Nhal_1618 5.65e-110 357.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RRAN@1236|Gammaproteobacteria,1X04F@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_7 MMS2_k127_1415065_0 2340.JV46_19080 0.0 1438.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1J8A6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding MMS2_k127_1415065_5 1219076.N646_0566 0.0008684 44.0 2EH97@1|root,33B11@2|Bacteria,1NHPA@1224|Proteobacteria,1SGUW@1236|Gammaproteobacteria,1XYW7@135623|Vibrionales 135623|Vibrionales S TIGRFAM formate dehydrogenase region TAT target - - - - - - - - - - - - TAT_signal MMS2_k127_1415065_3 1123400.KB904768_gene3406 4.452e-56 205.0 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,462Q6@72273|Thiotrichales 72273|Thiotrichales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del MMS2_k127_1415065_1 713587.THITH_02125 1.221e-124 415.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4,Fer4_10,Fer4_6,Fer4_7 MMS2_k127_1417868_6 1485545.JQLW01000010_gene1663 1.264e-37 149.0 COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria 1224|Proteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 MMS2_k127_1417868_7 743299.Acife_0760 2.43e-08 59.0 COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,1RZ28@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG1225 Peroxiredoxin - - - - - - - - - - - - AhpC-TSA MMS2_k127_1417868_5 396595.TK90_1869 4.432e-41 160.0 COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,1RMES@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Transcriptional regulator modE - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1 MMS2_k127_1417868_2 768671.ThimaDRAFT_4061 2.74e-135 456.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N MMS2_k127_1417868_1 765912.Thimo_3283 5.772e-168 536.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 MMS2_k127_1417868_3 396588.Tgr7_2463 1.694e-103 343.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1WWRN@135613|Chromatiales 135613|Chromatiales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N MMS2_k127_1417868_0 713586.KB900536_gene1253 1.525e-286 891.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales 135613|Chromatiales E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 MMS2_k127_1417868_4 1232410.KI421413_gene484 1.417e-42 158.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,437CT@68525|delta/epsilon subdivisions,2XA0U@28221|Deltaproteobacteria,43VKC@69541|Desulfuromonadales 28221|Deltaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX MMS2_k127_147667_14 713586.KB900536_gene1031 7.098e-118 394.0 COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,1RMGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes lplA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0017118,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_4078,iE2348C_1286.E2348C_4684,iECDH10B_1368.ECDH10B_4544,iECDH1ME8569_1439.ECDH1ME8569_4242,iEcDH1_1363.EcDH1_3612,iJO1366.b4386,iSDY_1059.SDY_4647,iY75_1357.Y75_RS22890 BPL_LplA_LipB,Lip_prot_lig_C MMS2_k127_147667_4 396588.Tgr7_2207 7.537e-209 653.0 COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,1SKHD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SMART Elongator protein 3 MiaB NifB - - - ko:K09711 - - - - ko00000 - - - Radical_SAM MMS2_k127_147667_24 396588.Tgr7_2208 7.459e-81 271.0 COG0509@1|root,COG0509@2|Bacteria,1RKRS@1224|Proteobacteria,1T0BR@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein - - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H MMS2_k127_147667_32 396588.Tgr7_2209 4.92e-66 227.0 COG2044@1|root,COG2044@2|Bacteria,1N7MM@1224|Proteobacteria,1SCQA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DsrE/DsrF-like family - - - ko:K07092 - - - - ko00000 - - - DrsE MMS2_k127_147667_23 545264.KB898753_gene1740 2.029e-81 272.0 COG0509@1|root,COG0509@2|Bacteria,1NUDG@1224|Proteobacteria,1SNQA@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glycine cleavage - - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H MMS2_k127_147667_6 396588.Tgr7_2211 7.731e-187 585.0 COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,1SBBX@1236|Gammaproteobacteria,1X060@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG MMS2_k127_147667_15 765914.ThisiDRAFT_1535 4.259e-115 374.0 COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,1SHQ0@1236|Gammaproteobacteria,1WZZ0@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390,ko:K16887 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_17,Fer4_8 MMS2_k127_147667_30 519989.ECTPHS_10846 6.97e-71 254.0 arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,1SNV0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_147667_3 396588.Tgr7_2214 9.644e-210 654.0 COG0446@1|root,COG1148@1|root,COG0446@2|Bacteria,COG1148@2|Bacteria,1R882@1224|Proteobacteria,1SAD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2 MMS2_k127_147667_2 1158762.KB898048_gene661 1.656e-289 891.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,1SJXJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG MMS2_k127_147667_11 396588.Tgr7_2216 1.357e-147 467.0 COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,1SMDU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_8 MMS2_k127_147667_39 396588.Tgr7_2218 9.979e-41 154.0 COG0607@1|root,COG0607@2|Bacteria,1QMXA@1224|Proteobacteria,1S6DI@1236|Gammaproteobacteria,1X2DB@135613|Chromatiales 135613|Chromatiales P PFAM Rhodanese-like - - - - - - - - - - - - Rhodanese MMS2_k127_147667_44 396588.Tgr7_2219 5.806e-33 130.0 2CARZ@1|root,2ZDWQ@2|Bacteria,1P7T2@1224|Proteobacteria,1STXE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_147667_22 519989.ECTPHS_10806 1.989e-89 314.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales 135613|Chromatiales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 MMS2_k127_147667_45 1123514.KB905899_gene555 5.285e-31 126.0 COG2010@1|root,COG2010@2|Bacteria,1N91W@1224|Proteobacteria,1SD5N@1236|Gammaproteobacteria,461B4@72273|Thiotrichales 72273|Thiotrichales C Cytochrome c - - - ko:K17223 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - Cytochrom_C,Cytochrome_CBB3 MMS2_k127_147667_36 519989.ECTPHS_10801 1.137e-44 167.0 COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,1S2ZH@1236|Gammaproteobacteria,1WXZY@135613|Chromatiales 135613|Chromatiales S Sulfur oxidation protein SoxY - - - ko:K17226 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxY MMS2_k127_147667_43 519989.ECTPHS_10796 7.626e-34 133.0 COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,1SCTJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Sulphur oxidation protein SoxZ soxZ - - ko:K17227 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - SoxZ MMS2_k127_147667_18 1415754.JQMK01000013_gene117 2.543e-105 350.0 COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,1RS6A@1236|Gammaproteobacteria,469SU@72275|Alteromonadaceae 1236|Gammaproteobacteria C C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the intermediary formation of conspicuous sulfur globules inside of the cells soxA - 1.8.2.2 ko:K17222,ko:K19713 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - - MMS2_k127_147667_27 519989.ECTPHS_00490 3.181e-75 267.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,1RS25@1236|Gammaproteobacteria,1WXAZ@135613|Chromatiales 135613|Chromatiales T EAL domain - - - - - - - - - - - - EAL,HDOD MMS2_k127_147667_0 269482.Bcep1808_0605 0.0 1172.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae 28216|Betaproteobacteria C Malic enzyme maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic MMS2_k127_147667_21 1304885.AUEY01000020_gene3483 8.864e-95 317.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,42MZB@68525|delta/epsilon subdivisions,2WKV4@28221|Deltaproteobacteria,2MJJK@213118|Desulfobacterales 28221|Deltaproteobacteria P Integral membrane protein TerC family - - - - - - - - - - - - TerC MMS2_k127_147667_12 998674.ATTE01000001_gene2810 6.674e-145 474.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,1RSMW@1236|Gammaproteobacteria,4628N@72273|Thiotrichales 72273|Thiotrichales S Sulphur transport - - - - - - - - - - - - Sulf_transp MMS2_k127_147667_17 287.DR97_961 3.687e-108 353.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1YCVM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC MMS2_k127_147667_20 713586.KB900536_gene1043 1.247e-97 325.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WW37@135613|Chromatiales 135613|Chromatiales O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM MMS2_k127_147667_42 396588.Tgr7_2227 3.897e-36 149.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales 135613|Chromatiales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri,YfiO MMS2_k127_147667_41 765914.ThisiDRAFT_2251 1.098e-37 152.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1WYG6@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA MMS2_k127_147667_13 396588.Tgr7_2229 4.65e-134 441.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales 135613|Chromatiales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N MMS2_k127_147667_46 555778.Hneap_0535 7.135e-21 104.0 COG3064@1|root,COG3064@2|Bacteria,1NDEI@1224|Proteobacteria,1T2B3@1236|Gammaproteobacteria,1X2R6@135613|Chromatiales 135613|Chromatiales M PFAM Tol-Pal system TolA - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - TonB_2 MMS2_k127_147667_40 1279019.ARQK01000054_gene192 3.291e-40 154.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1X279@135613|Chromatiales 135613|Chromatiales U Biopolymer transport protein ExbD/TolR - - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD MMS2_k127_147667_26 323261.Noc_0142 2.948e-77 264.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB MMS2_k127_147667_37 572477.Alvin_0951 2.583e-42 159.0 COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1WYUJ@135613|Chromatiales 135613|Chromatiales S Tol-Pal system-associated acyl-CoA thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 MMS2_k127_147667_8 640081.Dsui_2360 8.911e-163 524.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Sigma54_activat MMS2_k127_147667_19 1123368.AUIS01000005_gene447 1.68e-99 343.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales 225057|Acidithiobacillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA MMS2_k127_147667_7 396588.Tgr7_2234 4.436e-170 541.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N MMS2_k127_147667_31 396588.Tgr7_2235 4.836e-67 235.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N MMS2_k127_147667_34 519989.ECTPHS_02159 1.452e-57 204.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales 135613|Chromatiales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC MMS2_k127_147667_16 519989.ECTPHS_02154 1.043e-113 371.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales 135613|Chromatiales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg MMS2_k127_147667_28 396588.Tgr7_2238 3.346e-74 255.0 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,1WZS4@135613|Chromatiales 135613|Chromatiales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_6 MMS2_k127_147667_38 519989.ECTPHS_02149 2.073e-41 159.0 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,1S20Q@1236|Gammaproteobacteria,1WY8G@135613|Chromatiales 135613|Chromatiales L pfam nudix - - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX MMS2_k127_147667_1 713586.KB900536_gene1057 7.6e-322 991.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales 135613|Chromatiales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon MMS2_k127_147667_9 1033802.SSPSH_002212 5.41e-160 516.0 COG4267@1|root,COG4267@2|Bacteria,1MUQN@1224|Proteobacteria,1RP96@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane pelG - - ko:K21012 ko02025,map02025 - - - ko00000,ko00001 - - - PelG MMS2_k127_147667_5 378806.STAUR_3669 3.197e-192 621.0 COG0438@1|root,COG0438@2|Bacteria,1MVEG@1224|Proteobacteria,42Q1K@68525|delta/epsilon subdivisions,2WJ1U@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Domain of unknown function (DUF3492) - - - ko:K21011 ko02025,map02025 - - - ko00000,ko00001,ko01003 - GT4 - DUF3492,Glycos_transf_1 MMS2_k127_147667_33 301.JNHE01000045_gene3819 4.217e-60 220.0 COG1413@1|root,COG1413@2|Bacteria,1QTUR@1224|Proteobacteria,1S7VI@1236|Gammaproteobacteria,1YFRM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C lyase activity pelE - - ko:K21010 ko02025,map02025 - - - ko00000,ko00001 - - - - MMS2_k127_147667_25 287.DR97_4875 8.17e-78 277.0 COG2203@1|root,COG2203@2|Bacteria,1PB4M@1224|Proteobacteria,1S5S4@1236|Gammaproteobacteria,1YECA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T PelD GGDEF domain pelD - - ko:K21009 ko02025,map02025 - - - ko00000,ko00001 - - - GAF_3,PelD_GGDEF MMS2_k127_147667_35 1033802.SSPSH_002216 5.356e-52 189.0 COG5616@1|root,COG5616@2|Bacteria,1N092@1224|Proteobacteria,1RMRI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - ko:K21008 ko02025,map02025 - - - ko00000,ko00001 - - - - MMS2_k127_147667_29 378806.STAUR_3672 3.444e-73 281.0 COG0457@1|root,COG0457@2|Bacteria,1MWAQ@1224|Proteobacteria 1224|Proteobacteria NU Tetratricopeptide repeat pelB - - ko:K21007 ko02025,map02025 - - - ko00000,ko00001 - - - TPR_15,TPR_19 MMS2_k127_147667_10 1033802.SSPSH_002218 3.058e-152 497.0 COG3868@1|root,COG3868@2|Bacteria,1MXYK@1224|Proteobacteria,1RMK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Glycoside-hydrolase family GH114 pelA - - ko:K21006 ko02025,map02025 - - - ko00000,ko00001 - - - Glyco_hydro_114 MMS2_k127_1484042_5 555778.Hneap_0567 1.986e-47 176.0 COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,1QTY9@1224|Proteobacteria,1S0UZ@1236|Gammaproteobacteria,1X02Y@135613|Chromatiales 135613|Chromatiales M NHL repeat - - - - - - - - - - - - NHL MMS2_k127_1484042_3 743721.Psesu_2691 4.014e-84 306.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X3Q4@135614|Xanthomonadales 135614|Xanthomonadales T GGDEF domain - - - - - - - - - - - - CHASE,EAL,GGDEF MMS2_k127_1484042_0 713586.KB900536_gene345 0.0 2601.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran MMS2_k127_1484042_4 1168067.JAGP01000001_gene2126 9.419e-56 204.0 COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,1S7MT@1236|Gammaproteobacteria,462U1@72273|Thiotrichales 72273|Thiotrichales K Putative FMN-binding domain - - - - - - - - - - - - FMN_bind_2 MMS2_k127_1484042_1 1249627.D779_3628 1.434e-105 354.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_4 MMS2_k127_1484042_2 234267.Acid_1799 1.551e-89 302.0 COG0384@1|root,COG0384@2|Bacteria,3Y7JN@57723|Acidobacteria 57723|Acidobacteria S PFAM Phenazine biosynthesis PhzC PhzF protein - - - - - - - - - - - - PhzC-PhzF MMS2_k127_1485220_4 713586.KB900536_gene1264 2.853e-86 291.0 COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutamine amidotransferase egtC - - - - - - - - - - - GATase_4 MMS2_k127_1485220_3 765914.ThisiDRAFT_2326 6.707e-109 357.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1WVZG@135613|Chromatiales 135613|Chromatiales T phosphate regulon transcriptional regulatory protein PhoB - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C MMS2_k127_1485220_1 519989.ECTPHS_12943 1.318e-141 462.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,1RN0F@1236|Gammaproteobacteria,1WWCF@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 MMS2_k127_1485220_0 713586.KB900536_gene1259 8.009e-166 536.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales 135613|Chromatiales FP Belongs to the GppA Ppx family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA MMS2_k127_1485220_5 1122185.N792_05770 1.768e-53 193.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1X6M0@135614|Xanthomonadales 135614|Xanthomonadales S LemA family - - - - - - - - - - - - LemA MMS2_k127_1485220_2 1121448.DGI_3104 1.599e-115 389.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 MMS2_k127_1521579_41 1123368.AUIS01000024_gene944 6.521e-07 58.0 COG3170@1|root,COG3170@2|Bacteria,1QDEM@1224|Proteobacteria,1S884@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF1207) - - - - - - - - - - - - DUF1207 MMS2_k127_1521579_3 1116472.MGMO_137c00030 2.314e-229 719.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1XDV5@135618|Methylococcales 135618|Methylococcales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon MMS2_k127_1521579_9 765913.ThidrDRAFT_3168 2.225e-173 548.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales 135613|Chromatiales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 MMS2_k127_1521579_13 1454004.AW11_02544 2.409e-153 492.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,1KQ7Y@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Zinc-binding dehydrogenase - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS2_k127_1521579_31 292.DM42_5379 5.488e-87 292.0 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2VMVW@28216|Betaproteobacteria,1K3NI@119060|Burkholderiaceae 28216|Betaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N MMS2_k127_1521579_6 338963.Pcar_0817 5.423e-197 620.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43T7M@69541|Desulfuromonadales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD MMS2_k127_1521579_21 338963.Pcar_0816 1.147e-120 391.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WJE9@28221|Deltaproteobacteria,43TKW@69541|Desulfuromonadales 28221|Deltaproteobacteria P ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_1521579_10 338963.Pcar_0815 2.451e-164 527.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,43TSN@69541|Desulfuromonadales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 MMS2_k127_1521579_8 338963.Pcar_0814 1.031e-175 563.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,43UH2@69541|Desulfuromonadales 28221|Deltaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP MMS2_k127_1521579_37 946483.Cenrod_0706 5.958e-34 139.0 COG1309@1|root,COG1309@2|Bacteria,1NPF5@1224|Proteobacteria,2WFXG@28216|Betaproteobacteria 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS2_k127_1521579_38 555778.Hneap_1972 1.602e-26 118.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales 135613|Chromatiales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC MMS2_k127_1521579_34 396588.Tgr7_1235 1.573e-46 177.0 COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,1WZ46@135613|Chromatiales 135613|Chromatiales S PFAM electron transport protein SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC MMS2_k127_1521579_39 1123392.AQWL01000002_gene1938 1.182e-25 113.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,1KT10@119069|Hydrogenophilales 119069|Hydrogenophilales CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA,Redoxin MMS2_k127_1521579_26 349163.Acry_0356 7.414e-103 341.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2JQ6B@204441|Rhodospirillales 204441|Rhodospirillales E COG0410 ABC-type branched-chain amino acid transport systems, ATPase component - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS2_k127_1521579_27 1437824.BN940_11411 9.659e-102 352.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,3T22A@506|Alcaligenaceae 28216|Betaproteobacteria E ABC-type branched-chain amino acid transport systems ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS2_k127_1521579_17 75379.Tint_3189 2.11e-127 429.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2W1KD@28216|Betaproteobacteria,1KP99@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_1521579_16 1408418.JNJH01000037_gene501 4.337e-135 436.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_1521579_11 349163.Acry_0360 6.811e-157 503.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,2JQNJ@204441|Rhodospirillales 204441|Rhodospirillales E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS2_k127_1521579_12 555778.Hneap_0137 1.03e-154 497.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,1WXY2@135613|Chromatiales 135613|Chromatiales P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA MMS2_k127_1521579_15 1159870.KB907784_gene295 9.553e-147 477.0 COG1226@1|root,COG1226@2|Bacteria,1R3QQ@1224|Proteobacteria,2VJM4@28216|Betaproteobacteria,3T2ZS@506|Alcaligenaceae 28216|Betaproteobacteria P potassium channel kch - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_N MMS2_k127_1521579_7 314278.NB231_01554 3.59e-190 609.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1WWB4@135613|Chromatiales 135613|Chromatiales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 MMS2_k127_1521579_5 713586.KB900536_gene646 1.475e-208 687.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales 135613|Chromatiales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 MMS2_k127_1521579_20 396588.Tgr7_1850 2.31e-123 411.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,1WYFQ@135613|Chromatiales 135613|Chromatiales S A domain family that is part of the cupin metalloenzyme superfamily. - - 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 MMS2_k127_1521579_36 748247.AZKH_2890 5.921e-37 150.0 COG1376@1|root,COG2153@1|root,COG1376@2|Bacteria,COG2153@2|Bacteria,1RHBG@1224|Proteobacteria,2VQT7@28216|Betaproteobacteria,2KWDI@206389|Rhodocyclales 206389|Rhodocyclales S ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD MMS2_k127_1521579_33 1116472.MGMO_30c00080 3.321e-56 208.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S3VR@1236|Gammaproteobacteria,1XDX1@135618|Methylococcales 135618|Methylococcales O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 MMS2_k127_1521579_42 243159.AFE_0104 1.357e-06 52.0 2AQ9E@1|root,31FFA@2|Bacteria,1QCYY@1224|Proteobacteria,1T8T2@1236|Gammaproteobacteria,2NDDG@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_1521579_19 396588.Tgr7_1236 1.293e-123 405.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS MMS2_k127_1521579_28 870187.Thini_0330 4.624e-101 338.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,460DD@72273|Thiotrichales 72273|Thiotrichales I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase MMS2_k127_1521579_25 713586.KB900536_gene85 2.394e-106 354.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales 135613|Chromatiales J Elongation factor P--(R)-beta-lysine ligase - - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 MMS2_k127_1521579_29 396588.Tgr7_1232 7.93e-99 342.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1WX8C@135613|Chromatiales 135613|Chromatiales J Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C MMS2_k127_1521579_18 1384054.N790_06905 1.208e-125 411.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1X3RU@135614|Xanthomonadales 135614|Xanthomonadales E lysine 2,3-aminomutase - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM MMS2_k127_1521579_24 396588.Tgr7_1230 2.743e-107 370.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1X1SU@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_1521579_4 396588.Tgr7_1229 2.556e-225 718.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales 135613|Chromatiales T PFAM EAL domain - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg MMS2_k127_1521579_22 396588.Tgr7_2118 1.02e-117 386.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 MMS2_k127_1521579_0 396588.Tgr7_2119 0.0 1097.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV MMS2_k127_1521579_14 396588.Tgr7_2120 2.686e-153 490.0 COG0560@1|root,COG0560@2|Bacteria,1R6HK@1224|Proteobacteria,1S00M@1236|Gammaproteobacteria 1236|Gammaproteobacteria E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD MMS2_k127_1521579_1 396588.Tgr7_2123 0.0 1063.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim MMS2_k127_1521579_30 396588.Tgr7_0932 2.011e-95 320.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,1RNGA@1236|Gammaproteobacteria,1WX4Y@135613|Chromatiales 135613|Chromatiales G Protein of unknown function (DUF455) - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF455 MMS2_k127_1521579_32 713586.KB900536_gene930 7.282e-84 288.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales 135613|Chromatiales O PFAM Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin MMS2_k127_1521579_40 1219035.NT2_08_01360 3.163e-10 63.0 COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales 204457|Sphingomonadales L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom MMS2_k127_1521579_23 396588.Tgr7_1005 8.301e-114 374.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N MMS2_k127_1521579_35 519989.ECTPHS_07252 7.817e-42 158.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1WYHM@135613|Chromatiales 135613|Chromatiales J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA MMS2_k127_1521579_2 396588.Tgr7_1003 1.79e-315 984.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc MMS2_k127_1569285_1 1195246.AGRI_01655 2.315e-92 307.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,465EE@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N MMS2_k127_1569285_3 1502851.FG93_01729 2.616e-43 163.0 COG1522@1|root,COG1522@2|Bacteria,1RI7R@1224|Proteobacteria,2U9CC@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator dadR - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type MMS2_k127_1569285_2 1395571.TMS3_0106305 4.405e-76 262.0 COG1296@1|root,COG1296@2|Bacteria,1MVGN@1224|Proteobacteria,1S85J@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Branched-chain amino acid permease - - - - - - - - - - - - AzlC MMS2_k127_1569285_4 1395571.TMS3_0106300 2.319e-23 112.0 COG4392@1|root,COG4392@2|Bacteria,1NH6U@1224|Proteobacteria,1SGUY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S branched-chain amino acid - - - - - - - - - - - - AzlD MMS2_k127_1569285_0 1207063.P24_05702 2.413e-247 772.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,2JQQU@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS2_k127_1577905_1 713586.KB900536_gene1489 2.262e-54 203.0 COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1WZMR@135613|Chromatiales 135613|Chromatiales V Membrane protein required for beta-lactamase induction - - - ko:K03807 - - - - ko00000 - - - AmpE,CobD_Cbib MMS2_k127_1577905_0 765910.MARPU_14515 1.735e-71 257.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales 135613|Chromatiales V PFAM N-acetylmuramoyl-L-alanine amidase family 2 - - 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 MMS2_k127_1577905_2 396588.Tgr7_0629 4.219e-24 105.0 COG0526@1|root,COG0526@2|Bacteria,1NC9Q@1224|Proteobacteria,1T0R2@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Thioredoxin MMS2_k127_1577905_3 1049564.TevJSym_al00300 4.927e-06 49.0 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,1J4E1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 MMS2_k127_1578404_3 396588.Tgr7_2273 5.392e-58 205.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1WY5P@135613|Chromatiales 135613|Chromatiales J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase MMS2_k127_1578404_2 713586.KB900536_gene1093 6.188e-63 223.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales 135613|Chromatiales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf MMS2_k127_1578404_0 1255043.TVNIR_3408 1.11e-209 666.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 MMS2_k127_1578404_1 519989.ECTPHS_02991 7.806e-121 428.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 MMS2_k127_1610002_11 555778.Hneap_0164 6.157e-08 55.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt MMS2_k127_1610002_12 224911.27350827 0.0001222 46.0 2F0SV@1|root,33TUX@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS2_k127_1610002_4 748247.AZKH_1521 6.928e-101 342.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,2KUUB@206389|Rhodocyclales 206389|Rhodocyclales V Biotin-lipoyl like - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 MMS2_k127_1610002_2 1123393.KB891326_gene224 7.027e-188 602.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2VJGS@28216|Betaproteobacteria,1KRP0@119069|Hydrogenophilales 119069|Hydrogenophilales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS2_k127_1610002_3 637390.AFOH01000107_gene142 6.657e-119 394.0 COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,1T7WD@1236|Gammaproteobacteria,2NBZU@225057|Acidithiobacillales 225057|Acidithiobacillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS2_k127_1610002_6 396588.Tgr7_3187 9.232e-79 269.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1WY9P@135613|Chromatiales 135613|Chromatiales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin MMS2_k127_1610002_9 713586.KB900536_gene1922 3.087e-31 125.0 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 MMS2_k127_1610002_0 713586.KB900536_gene1923 0.0 1009.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS MMS2_k127_1610002_7 765911.Thivi_4151 1.843e-57 201.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP MMS2_k127_1610002_1 519989.ECTPHS_11727 2.492e-268 842.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1WW2Y@135613|Chromatiales 135613|Chromatiales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge MMS2_k127_1610002_8 1123368.AUIS01000007_gene2671 8.08e-35 138.0 COG1416@1|root,COG1416@2|Bacteria,1RBQX@1224|Proteobacteria,1SDBN@1236|Gammaproteobacteria,2NDS4@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE MMS2_k127_1610002_5 713586.KB900536_gene1928 1.423e-88 297.0 COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,1RRYH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 MMS2_k127_1610002_10 1385517.N800_09740 5.155e-15 78.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1X4VN@135614|Xanthomonadales 135614|Xanthomonadales D Reduces the stability of FtsZ polymers in the presence of ATP zapE - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase MMS2_k127_1610557_8 1114856.C496_21277 2.613e-07 62.0 COG2897@1|root,arCOG02019@2157|Archaea,2XT2C@28890|Euryarchaeota,23THW@183963|Halobacteria 183963|Halobacteria P COG2897 Rhodanese-related sulfurtransferase sseA2 - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese MMS2_k127_1610557_5 155864.EDL933_3086 2.826e-16 91.0 COG2391@1|root,COG2391@2|Bacteria,1MWWP@1224|Proteobacteria,1RR58@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Inner membrane protein PRK11099 yeeE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07112 - - - - ko00000 - - - Sulf_transp MMS2_k127_1610557_6 941639.BCO26_1303 1.028e-15 83.0 COG2391@1|root,COG2391@2|Bacteria,1TS24@1239|Firmicutes,4HCX1@91061|Bacilli,1ZS0U@1386|Bacillus 91061|Bacilli S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp MMS2_k127_1610557_0 713586.KB900536_gene2159 1.613e-112 378.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat MMS2_k127_1610557_1 713586.KB900536_gene537 5.059e-110 372.0 COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,1S5D2@1236|Gammaproteobacteria,1WYVS@135613|Chromatiales 135613|Chromatiales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA MMS2_k127_1610557_3 713586.KB900536_gene536 1.047e-55 205.0 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,1SEYJ@1236|Gammaproteobacteria,1X2JC@135613|Chromatiales 135613|Chromatiales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd MMS2_k127_1610557_10 1111728.ATYS01000002_gene1901 0.0006157 48.0 2DRC0@1|root,33B61@2|Bacteria,1NHS4@1224|Proteobacteria,1SGUR@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1610557_2 1335757.SPICUR_09465 3.671e-92 315.0 28JFR@1|root,2Z99N@2|Bacteria,1R7C5@1224|Proteobacteria,1RZYU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_164332_4 396588.Tgr7_1564 4.104e-37 147.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C MMS2_k127_164332_3 519989.ECTPHS_05841 1.679e-47 174.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1WY2Q@135613|Chromatiales 135613|Chromatiales K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB MMS2_k127_164332_2 998674.ATTE01000001_gene1512 3.407e-66 230.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,460J0@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase MMS2_k127_164332_0 1123401.JHYQ01000007_gene538 7.256e-200 644.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQZD@1236|Gammaproteobacteria,462XH@72273|Thiotrichales 72273|Thiotrichales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,sCache_3_3 MMS2_k127_164332_1 713586.KB900536_gene981 7.06e-166 535.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat MMS2_k127_1648920_3 555778.Hneap_1927 2.053e-235 743.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWES@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C MMS2_k127_1648920_9 1163617.SCD_n00990 2.106e-179 571.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2VH8N@28216|Betaproteobacteria 28216|Betaproteobacteria S HI0933 family - - - ko:K07007 - - - - ko00000 - - - HI0933_like MMS2_k127_1648920_18 1288826.MSNKSG1_07263 2.368e-76 258.0 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,1RPGA@1236|Gammaproteobacteria,466YU@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG1522 Transcriptional regulators lrp_2 - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 MMS2_k127_1648920_1 243159.AFE_1989 2.681e-258 809.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,2NCNJ@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer MMS2_k127_1648920_23 1162668.LFE_1241 2.922e-57 213.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GGDEF,NMT1,PAS_9,SBP_bac_3,dCache_1 MMS2_k127_1648920_28 1397527.Q670_05175 7.494e-38 151.0 290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,1S3RZ@1236|Gammaproteobacteria,1XKS8@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - MMS2_k127_1648920_20 1439940.BAY1663_01376 5.366e-75 256.0 COG3791@1|root,COG3791@2|Bacteria,1RD31@1224|Proteobacteria,1S42C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alanine acetyltransferase - - - - - - - - - - - - GFA MMS2_k127_1648920_26 290315.Clim_0505 1.169e-44 167.0 COG0824@1|root,COG0824@2|Bacteria 2|Bacteria IQ Thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - Acyl-ACP_TE MMS2_k127_1648920_21 670292.JH26_11090 5.184e-73 257.0 COG3246@1|root,COG3246@2|Bacteria,1MXEF@1224|Proteobacteria,2U387@28211|Alphaproteobacteria,1JTSS@119045|Methylobacteriaceae 28211|Alphaproteobacteria S beta-keto acid cleavage enzyme - - - - - - - - - - - - BKACE MMS2_k127_1648920_7 388051.AUFE01000021_gene137 6.645e-197 622.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VJJ6@28216|Betaproteobacteria,1K0AP@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 MMS2_k127_1648920_0 713587.THITH_16310 0.0 1876.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans MMS2_k127_1648920_13 396588.Tgr7_1324 1.687e-127 426.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WXMA@135613|Chromatiales 135613|Chromatiales T Chemotaxis sensory transducer - - - ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3 MMS2_k127_1648920_10 637390.AFOH01000081_gene2592 2.172e-147 490.0 COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RX09@1236|Gammaproteobacteria,2NDV0@225057|Acidithiobacillales 225057|Acidithiobacillales T diguanylate cyclase - - - - - - - - - - - - GGDEF,HDOD,Response_reg MMS2_k127_1648920_27 1161401.ASJA01000013_gene731 2.924e-42 162.0 2BY1R@1|root,349MM@2|Bacteria,1P29N@1224|Proteobacteria 1224|Proteobacteria S Haem-NO-binding - - - - - - - - - - - - HNOB MMS2_k127_1648920_22 1121106.JQKB01000064_gene5376 8.491e-67 245.0 COG0642@1|root,COG2199@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JQVJ@204441|Rhodospirillales 204441|Rhodospirillales T transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,Response_reg MMS2_k127_1648920_30 1541065.JRFE01000014_gene1303 2.663e-26 120.0 COG0745@1|root,COG0745@2|Bacteria,1G6W5@1117|Cyanobacteria,3VK3N@52604|Pleurocapsales 1117|Cyanobacteria KT PFAM Response regulator receiver domain - - - - - - - - - - - - Response_reg MMS2_k127_1648920_17 251229.Chro_5134 3.81e-78 288.0 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VIJ3@52604|Pleurocapsales 1117|Cyanobacteria T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_3,PAS_9 MMS2_k127_1648920_19 637390.AFOH01000130_gene1970 2.814e-75 258.0 COG2265@1|root,COG2265@2|Bacteria,1QV4X@1224|Proteobacteria,1S273@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family tpm - 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT MMS2_k127_1648920_31 1043493.BBLU01000003_gene2295 7.077e-07 60.0 2DE6A@1|root,2ZKP8@2|Bacteria,2HA4U@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS2_k127_1648920_16 1123257.AUFV01000001_gene1896 9.474e-105 350.0 COG0039@1|root,COG0039@2|Bacteria 2|Bacteria C L-malate dehydrogenase activity - - 1.1.1.27,1.1.1.37 ko:K00016,ko:K00024 ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R00703,R01000,R03104,R07136 RC00031,RC00044 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N MMS2_k127_1648920_33 1160718.SU9_01195 1.963e-05 56.0 COG0515@1|root,COG0515@2|Bacteria,2I3AC@201174|Actinobacteria 201174|Actinobacteria KLT Protein of unknown function (DUF4232) - - - - - - - - - - - - DUF4232 MMS2_k127_1648920_25 1286631.X805_11670 4.893e-45 171.0 COG1279@1|root,COG1279@2|Bacteria,1RD6B@1224|Proteobacteria,2VIHT@28216|Betaproteobacteria,1KKTS@119065|unclassified Burkholderiales 28216|Betaproteobacteria S LysE type translocator argO - - ko:K06895 - - - - ko00000,ko02000 2.A.75.1 - - LysE MMS2_k127_1648920_24 1492922.GY26_03400 1.433e-49 183.0 COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,1S5RX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DinB MMS2_k127_1648920_4 426114.THI_0061 5.075e-230 725.0 COG1249@1|root,COG1249@2|Bacteria,1MXQ3@1224|Proteobacteria,2VK4G@28216|Betaproteobacteria,1KN2Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria C L-lysine 6-monooxygenase (NADPH-requiring) - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim MMS2_k127_1648920_8 572477.Alvin_1837 2.604e-189 614.0 COG2010@1|root,COG2010@2|Bacteria,1NG71@1224|Proteobacteria,1RNZA@1236|Gammaproteobacteria,1WXHK@135613|Chromatiales 135613|Chromatiales C Cytochrome c - - - - - - - - - - - - - MMS2_k127_1648920_6 1120956.JHZK01000016_gene2203 1.77e-203 649.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2U4S4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 MMS2_k127_1648920_12 1304275.C41B8_05253 2.932e-142 472.0 COG1653@1|root,COG1653@2|Bacteria,1MUYE@1224|Proteobacteria,1RRFK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G ABC-type sugar transport system periplasmic component gtsA - - ko:K17315 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - SBP_bac_1,SBP_bac_8 MMS2_k127_1648920_15 1304275.C41B8_05258 5.058e-117 385.0 COG1175@1|root,COG1175@2|Bacteria,1MU84@1224|Proteobacteria,1S0D0@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1175 ABC-type sugar transport systems, permease components gtsB - - ko:K17316 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 MMS2_k127_1648920_14 1121939.L861_09500 6.19e-124 403.0 COG0395@1|root,COG0395@2|Bacteria,1MUT9@1224|Proteobacteria,1RZHT@1236|Gammaproteobacteria,1XHVR@135619|Oceanospirillales 135619|Oceanospirillales P PFAM binding-protein-dependent transport systems inner membrane component gtsC - - ko:K17317 ko02010,map02010 M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.24,3.A.1.1.30 - - BPD_transp_1 MMS2_k127_1648920_11 279714.FuraDRAFT_2615 7.616e-147 474.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria,2KSQS@206351|Neisseriales 206351|Neisseriales P TOBE domain - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE MMS2_k127_1648920_29 1255043.TVNIR_0201 1.153e-33 138.0 2E25Q@1|root,32XCG@2|Bacteria,1N1B8@1224|Proteobacteria,1S963@1236|Gammaproteobacteria,1WZ2N@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_1648920_2 1238190.AMQY01000014_gene1091 3.415e-239 765.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_9 MMS2_k127_1648920_32 1323663.AROI01000020_gene723 1.281e-05 53.0 COG0835@1|root,COG0835@2|Bacteria 2|Bacteria NT chemotaxis wspB - - ko:K03408,ko:K06598,ko:K13488 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035 - - - CheW MMS2_k127_1648920_5 396588.Tgr7_2900 2.276e-220 696.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg MMS2_k127_1664012_1 1417296.U879_05810 8.559e-142 458.0 COG0226@1|root,COG0226@2|Bacteria,1R9S4@1224|Proteobacteria,2UQQY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 MMS2_k127_1664012_7 1123368.AUIS01000010_gene2351 3.843e-62 220.0 COG0603@1|root,COG0603@2|Bacteria,1QCWR@1224|Proteobacteria,1T8QJ@1236|Gammaproteobacteria,2ND9J@225057|Acidithiobacillales 225057|Acidithiobacillales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC MMS2_k127_1664012_10 396588.Tgr7_2928 7.28e-24 104.0 294IN@1|root,2ZRY8@2|Bacteria,1P4SV@1224|Proteobacteria,1SUNI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1664012_5 1249627.D779_3899 6.112e-74 250.0 COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,1S64W@1236|Gammaproteobacteria,1WYAU@135613|Chromatiales 135613|Chromatiales O TIGRFAM Thioredoxin - - 1.8.1.8 ko:K03672 - - - - ko00000,ko01000,ko03110 - - - Thioredoxin MMS2_k127_1664012_4 713587.THITH_17040 1.157e-82 278.0 COG1628@1|root,COG1628@2|Bacteria,1RK51@1224|Proteobacteria,1T19V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF99 - - - ko:K09120 - - - - ko00000 - - - DUF99 MMS2_k127_1664012_2 1158762.KB898041_gene1245 2.076e-127 426.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1WWEH@135613|Chromatiales 135613|Chromatiales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core MMS2_k127_1664012_0 426114.THI_3252 1.157e-173 568.0 COG2199@1|root,COG2200@1|root,COG2200@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - CBS,GGDEF,PAS_9 MMS2_k127_1664012_6 118163.Ple7327_3771 1.776e-67 239.0 COG2203@1|root,COG2203@2|Bacteria,1GC2M@1117|Cyanobacteria 1117|Cyanobacteria T PFAM GAF domain - - - - - - - - - - - - GAF,GAF_2 MMS2_k127_1664012_3 1122139.KB907862_gene645 1.21e-108 379.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,1SKKE@1236|Gammaproteobacteria,1XS11@135619|Oceanospirillales 135619|Oceanospirillales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL MMS2_k127_1664012_9 1304275.C41B8_11628 3.88e-28 121.0 COG4731@1|root,COG4731@2|Bacteria,1QDFH@1224|Proteobacteria,1SF5X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 MMS2_k127_1664012_8 1415754.JQMK01000002_gene3046 1.066e-45 168.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,1S04N@1236|Gammaproteobacteria,46AEI@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - GAF_2,GGDEF,PAS_3,PAS_4 MMS2_k127_1672206_6 713586.KB900536_gene2508 2.499e-112 369.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 MMS2_k127_1672206_3 519989.ECTPHS_02124 6.803e-174 558.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales 135613|Chromatiales J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd MMS2_k127_1672206_1 426114.THI_3217 3.605e-240 756.0 COG4986@1|root,COG4986@2|Bacteria,1MV85@1224|Proteobacteria,2VHUU@28216|Betaproteobacteria,1KN4X@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 MMS2_k127_1672206_4 75379.Tint_2674 1.274e-171 549.0 COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria,1MUDV@1224|Proteobacteria,2VHKA@28216|Betaproteobacteria,1KN0F@119065|unclassified Burkholderiales 28216|Betaproteobacteria P C-terminal AAA-associated domain - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - AAA_assoc_C,ABC_tran MMS2_k127_1672206_10 1521187.JPIM01000060_gene2907 6.658e-79 279.0 COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi 200795|Chloroflexi C Pyridine nucleotide-disulphide oxidoreductase dimerisation region - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim MMS2_k127_1672206_9 396588.Tgr7_0698 1.456e-98 363.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1WX4U@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - DUF3391,HD_5 MMS2_k127_1672206_7 261292.Nit79A3_2661 8.7e-109 363.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2VMHH@28216|Betaproteobacteria,372QR@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM cation efflux protein czcD - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux,ZT_dimer MMS2_k127_1672206_13 522373.Smlt3382 2.218e-50 182.0 COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,1S60C@1236|Gammaproteobacteria,1X7HP@135614|Xanthomonadales 135614|Xanthomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase MMS2_k127_1672206_2 396588.Tgr7_0572 3.678e-180 573.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales 135613|Chromatiales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 MMS2_k127_1672206_16 1163409.UUA_10086 1.562e-27 121.0 COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,1S8TD@1236|Gammaproteobacteria,1X7HX@135614|Xanthomonadales 135614|Xanthomonadales P PFAM small multidrug resistance protein sugE - - ko:K11741 - - - - ko00000,ko02000 2.A.7.1 - - Multi_Drug_Res MMS2_k127_1672206_11 555778.Hneap_1510 1.019e-63 220.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1WYEZ@135613|Chromatiales 135613|Chromatiales E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase MMS2_k127_1672206_12 1283300.ATXB01000001_gene2303 1.353e-51 196.0 COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,1S6K8@1236|Gammaproteobacteria,1XEV4@135618|Methylococcales 135618|Methylococcales D Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization minC - - ko:K03610 - - - - ko00000,ko03036,ko04812 - - - MinC_C,MinC_N MMS2_k127_1672206_5 1124991.MU9_2091 2.812e-131 424.0 COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the ParA family minD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007059,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051782,GO:0060187,GO:0065007,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA MMS2_k127_1672206_20 545264.KB898756_gene1674 2.543e-20 102.0 COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,1SC8W@1236|Gammaproteobacteria,1WZ7H@135613|Chromatiales 135613|Chromatiales D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE MMS2_k127_1672206_19 396588.Tgr7_2533 4.544e-21 95.0 295VU@1|root,2ZT6U@2|Bacteria,1P5Q8@1224|Proteobacteria,1SU2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1672206_14 314278.NB231_01469 2.254e-42 173.0 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria,1RSAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1672206_17 713587.THITH_10250 9.254e-24 103.0 2E3CN@1|root,32YBX@2|Bacteria,1N716@1224|Proteobacteria,1SEFN@1236|Gammaproteobacteria,1WYWS@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_1672206_15 713586.KB900536_gene1429 1.964e-39 152.0 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,1S91G@1236|Gammaproteobacteria,1WZ1N@135613|Chromatiales 135613|Chromatiales T Belongs to the BolA IbaG family - - - ko:K05527 - - - - ko00000,ko03000 - - - BolA MMS2_k127_1672206_18 498211.CJA_1626 2.415e-23 105.0 2E4UA@1|root,32ZNM@2|Bacteria,1NAZR@1224|Proteobacteria,1SC82@1236|Gammaproteobacteria,1FHQY@10|Cellvibrio 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_1672206_8 519989.ECTPHS_02726 1.221e-102 340.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1WVVE@135613|Chromatiales 135613|Chromatiales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A MMS2_k127_1672206_0 396588.Tgr7_2778 0.0 2014.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 MMS2_k127_1672206_21 75379.Tint_2839 1.498e-12 79.0 COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,2VN8D@28216|Betaproteobacteria,1KNXK@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Gram-negative porin - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03285 - - - - ko00000 1.B.1 - - Porin_4 MMS2_k127_1734517_15 395493.BegalDRAFT_2995 1.797e-31 128.0 2A8YE@1|root,30Y24@2|Bacteria,1QBAG@1224|Proteobacteria,1T6V4@1236|Gammaproteobacteria,463E0@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - MMS2_k127_1734517_4 870187.Thini_2861 7.96e-209 661.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,4603K@72273|Thiotrichales 72273|Thiotrichales O magnesium chelatase - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C MMS2_k127_1734517_18 519989.ECTPHS_04114 1.369e-20 95.0 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria yqiC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09806 - - - - ko00000 - - - BMFP MMS2_k127_1734517_12 519989.ECTPHS_04104 3.735e-56 199.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WY86@135613|Chromatiales 135613|Chromatiales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II MMS2_k127_1734517_3 555778.Hneap_2356 6.275e-210 661.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales 135613|Chromatiales U Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp MMS2_k127_1734517_11 85643.Tmz1t_0166 1.619e-59 214.0 COG1123@1|root,COG1123@2|Bacteria,1QVC6@1224|Proteobacteria,2WGPQ@28216|Betaproteobacteria,2KYI3@206389|Rhodocyclales 206389|Rhodocyclales P ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran MMS2_k127_1734517_9 1158146.KB907123_gene764 1.746e-107 357.0 COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1WW8S@135613|Chromatiales 135613|Chromatiales S PFAM conserved - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 MMS2_k127_1734517_10 1123368.AUIS01000014_gene2288 1.478e-63 220.0 COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,2NCUY@225057|Acidithiobacillales 225057|Acidithiobacillales T low molecular weight - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc MMS2_k127_1734517_2 1217720.ALOX01000027_gene3650 7.515e-214 672.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,2TV05@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Involved in arsenical resistance. Thought to form the channel of an arsenite pump arsB - - ko:K03893 - - - - ko00000,ko02000 2.A.45.1,3.A.4.1 - - ArsB,CitMHS MMS2_k127_1734517_14 396588.Tgr7_1925 6.199e-34 135.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,1SAI5@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5,LMWPc MMS2_k127_1734517_16 292415.Tbd_1429 1.871e-29 118.0 COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,2VWXC@28216|Betaproteobacteria 28216|Betaproteobacteria CO Thioredoxin domain - - - - - - - - - - - - Thioredoxin_3 MMS2_k127_1734517_5 1249627.D779_2579 1.406e-156 498.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria,1WX27@135613|Chromatiales 135613|Chromatiales S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 MMS2_k127_1734517_13 671143.DAMO_1123 8.985e-43 161.0 COG0394@1|root,COG0394@2|Bacteria,2NPGV@2323|unclassified Bacteria 2|Bacteria T Low molecular weight phosphatase family arsC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc MMS2_k127_1734517_6 1158146.KB907123_gene765 9.277e-140 452.0 COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1WX1H@135613|Chromatiales 135613|Chromatiales E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth MMS2_k127_1734517_1 396588.Tgr7_3124 2.552e-261 818.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales 135613|Chromatiales E Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N MMS2_k127_1734517_17 519989.ECTPHS_04159 4.058e-25 108.0 COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria,1WZKP@135613|Chromatiales 135613|Chromatiales S YcgL domain - - - ko:K09902 - - - - ko00000 - - - YcgL MMS2_k127_1734517_8 555778.Hneap_1587 9.099e-118 387.0 COG2197@1|root,COG2199@1|root,COG2197@2|Bacteria,COG3706@2|Bacteria,1R0WG@1224|Proteobacteria 1224|Proteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg MMS2_k127_1734517_0 555778.Hneap_1586 0.0 1467.0 COG0642@1|root,COG0745@1|root,COG1457@1|root,COG0745@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RRGT@1236|Gammaproteobacteria,1X2AB@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,Response_reg MMS2_k127_1734517_7 667014.Thein_1141 2.917e-122 400.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component urtA - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 MMS2_k127_177653_11 225937.HP15_1101 6.047e-07 52.0 COG2963@1|root,COG2963@2|Bacteria,1RKC9@1224|Proteobacteria,1S7IU@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 MMS2_k127_177653_0 1123399.AQVE01000004_gene2661 0.0 1749.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,45ZSY@72273|Thiotrichales 72273|Thiotrichales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 MMS2_k127_177653_6 396588.Tgr7_1991 1.985e-77 267.0 COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria,1WXEC@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.102,3.1.3.104 ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD_2 MMS2_k127_177653_4 1089550.ATTH01000001_gene1616 3.846e-150 482.0 COG1064@1|root,COG1064@2|Bacteria,4NFGP@976|Bacteroidetes,1FJFX@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K00001,ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS2_k127_177653_3 349163.Acry_2362 2.04e-159 512.0 COG0477@1|root,COG0477@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1 MMS2_k127_177653_7 572477.Alvin_1194 7.004e-67 237.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1WY36@135613|Chromatiales 135613|Chromatiales E PFAM lipolytic protein G-D-S-L family - - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 MMS2_k127_177653_5 568706.BN118_2126 1.292e-80 274.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,3T3FU@506|Alcaligenaceae 28216|Betaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis ATPase component lolD - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_177653_2 519989.ECTPHS_03592 1.266e-231 743.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales 135613|Chromatiales Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX MMS2_k127_177653_1 519989.ECTPHS_03587 9.772e-268 842.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WW1G@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS MMS2_k127_177653_9 765910.MARPU_07885 1.662e-37 157.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXCR@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS_9 MMS2_k127_1819885_2 396588.Tgr7_3205 2.937e-119 387.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt MMS2_k127_1819885_3 765914.ThisiDRAFT_2487 1.195e-44 164.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1WYVV@135613|Chromatiales 135613|Chromatiales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p MMS2_k127_1819885_4 203122.Sde_1009 6.793e-40 149.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,467SE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 MMS2_k127_1819885_1 765914.ThisiDRAFT_1305 2.295e-154 497.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales 135613|Chromatiales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 MMS2_k127_1819885_0 396588.Tgr7_3209 1.064e-162 519.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA MMS2_k127_1848381_10 765913.ThidrDRAFT_4285 2.582e-50 190.0 COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,1S6X5@1236|Gammaproteobacteria,1WY5W@135613|Chromatiales 135613|Chromatiales O PFAM NifZ - - - ko:K02597 - - - - ko00000 - - - NifZ MMS2_k127_1848381_13 1485544.JQKP01000001_gene982 7.258e-28 121.0 2E67S@1|root,330W8@2|Bacteria,1NA3E@1224|Proteobacteria,2VX71@28216|Betaproteobacteria,44WGB@713636|Nitrosomonadales 28216|Betaproteobacteria S Nitrogen fixation protein NifW nifW - - ko:K02595 - - - - ko00000 - - - NifW MMS2_k127_1848381_12 159087.Daro_1396 1.543e-40 157.0 COG0457@1|root,COG0457@2|Bacteria,1R714@1224|Proteobacteria,2VRZB@28216|Betaproteobacteria,2KXAR@206389|Rhodocyclales 206389|Rhodocyclales S Tetratricopeptide repeat - - - - - - - - - - - - - MMS2_k127_1848381_5 1485544.JQKP01000001_gene984 6.634e-102 337.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VMGF@28216|Betaproteobacteria,44WCG@713636|Nitrosomonadales 28216|Betaproteobacteria E Bacterial transferase hexapeptide (six repeats) nifP - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N MMS2_k127_1848381_1 519989.ECTPHS_05200 2.989e-158 507.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RRGA@1236|Gammaproteobacteria,1WX0C@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like MMS2_k127_1848381_4 1163617.SCD_n01056 1.559e-110 378.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria 28216|Betaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE MMS2_k127_1848381_6 765910.MARPU_09730 2.745e-89 301.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1WWGA@135613|Chromatiales 135613|Chromatiales P TIGRFAM Molybdate ABC transporter - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 MMS2_k127_1848381_9 686578.AFFX01000003_gene94 6.005e-69 254.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter, periplasmic molybdate-binding protein modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 MMS2_k127_1848381_8 765910.MARPU_09720 6.275e-70 247.0 COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,1RMES@1236|Gammaproteobacteria,1WXRR@135613|Chromatiales 135613|Chromatiales H Transcriptional regulator, ModE family - - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1,TOBE MMS2_k127_1848381_0 572477.Alvin_1401 1.716e-220 687.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWHG@135613|Chromatiales 135613|Chromatiales H Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 MMS2_k127_1848381_2 1122201.AUAZ01000022_gene3106 4.654e-143 458.0 COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,464R9@72275|Alteromonadaceae 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters nifU - - ko:K04488,ko:K13819 - - - - ko00000 - - - Fer2_BFD,NifU,NifU_N MMS2_k127_1848381_11 580332.Slit_0804 9.564e-45 164.0 COG0316@1|root,COG0316@2|Bacteria,1MZTE@1224|Proteobacteria,2VUJT@28216|Betaproteobacteria,44WGU@713636|Nitrosomonadales 28216|Betaproteobacteria S Iron-sulphur cluster biosynthesis - - - - - - - - - - - - Fe-S_biosyn MMS2_k127_1848381_3 269796.Rru_A2267 1.102e-113 387.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TSQX@28211|Alphaproteobacteria,2JQXH@204441|Rhodospirillales 204441|Rhodospirillales C Electron transfer flavoprotein domain fixA - - ko:K03521 - - - - ko00000 - - - ETF MMS2_k127_1848381_7 743299.Acife_1620 4.7e-83 280.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,1RMK7@1236|Gammaproteobacteria,2NDFX@225057|Acidithiobacillales 225057|Acidithiobacillales C Electron transfer flavoprotein, alpha subunit - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha MMS2_k127_1851537_1 1158292.JPOE01000002_gene3463 1.464e-54 192.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,1KKAE@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome bd terminal oxidase subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II MMS2_k127_1851537_0 426114.THI_0014 1.155e-241 756.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,1KJDA@119065|unclassified Burkholderiales 28216|Betaproteobacteria C cytochrome bd ubiquinol oxidase subunit I cydA1 - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I MMS2_k127_1910005_1 1417296.U879_06635 5.924e-117 380.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria 28211|Alphaproteobacteria P P-type ATPase' - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase MMS2_k127_1910005_3 1317124.DW2_00260 4.679e-60 210.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2UAEV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 MMS2_k127_1910005_5 743299.Acife_0697 1.899e-26 109.0 COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,1SGGE@1236|Gammaproteobacteria,2NDE2@225057|Acidithiobacillales 225057|Acidithiobacillales C PFAM Heavy metal transport detoxification protein - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA MMS2_k127_1910005_4 243159.AFE_2449 2.769e-34 133.0 COG0695@1|root,COG0695@2|Bacteria,1N38H@1224|Proteobacteria,1T0UZ@1236|Gammaproteobacteria,2NE0T@225057|Acidithiobacillales 225057|Acidithiobacillales O Glutaredoxin - - - - - - - - - - - - Glutaredoxin MMS2_k127_1910005_2 1158292.JPOE01000002_gene2019 1.639e-68 244.0 COG3794@1|root,COG3794@2|Bacteria,1R2S7@1224|Proteobacteria 1224|Proteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - MMS2_k127_1910005_6 504728.K649_01100 1.571e-06 55.0 COG3462@1|root,COG3462@2|Bacteria,1WKI9@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Short C-terminal domain - - - ko:K08982 - - - - ko00000 - - - SHOCT MMS2_k127_1910005_0 1317124.DW2_14600 4.894e-122 403.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2XN2W@285107|Thioclava 28211|Alphaproteobacteria E Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system ugpC GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264,GO:1901505 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 MMS2_k127_1940630_1 1121939.L861_14915 6.846e-141 453.0 COG2207@1|root,COG3449@1|root,COG2207@2|Bacteria,COG3449@2|Bacteria,1MWTF@1224|Proteobacteria,1RMKE@1236|Gammaproteobacteria,1XKHR@135619|Oceanospirillales 135619|Oceanospirillales K Bacterial transcription activator, effector binding domain - - - ko:K13652 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 MMS2_k127_1940630_4 511.JT27_13250 1.294e-71 248.0 COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,2VKQS@28216|Betaproteobacteria,3T3YQ@506|Alcaligenaceae 28216|Betaproteobacteria S NADPH-dependent FMN reductase - - - ko:K19784 - - - - ko00000 - - - FMN_red MMS2_k127_1940630_0 596153.Alide_2475 2.174e-146 478.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,4AB4T@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the pirin family yhhW_1 - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C MMS2_k127_1940630_3 82995.CR62_11420 1.929e-76 280.0 COG0583@1|root,COG0583@2|Bacteria,1MXDQ@1224|Proteobacteria,1RPBS@1236|Gammaproteobacteria,4012P@613|Serratia 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_1940630_2 1123366.TH3_09445 1.327e-92 316.0 COG0500@1|root,COG0500@2|Bacteria,1QVF3@1224|Proteobacteria,2TYAA@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 MMS2_k127_1940630_5 1392838.AWNM01000070_gene1184 1.254e-14 74.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VHDN@28216|Betaproteobacteria,3T4BJ@506|Alcaligenaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - DJ-1_PfpI,HTH_18 MMS2_k127_1942672_7 1122194.AUHU01000002_gene2664 1.461e-76 260.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,464WQ@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG0412 Dienelactone hydrolase and related enzymes yghX - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH MMS2_k127_1942672_9 1211815.CBYP010000020_gene1824 1.77e-74 259.0 COG0657@1|root,COG0657@2|Bacteria,2I2KK@201174|Actinobacteria 201174|Actinobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,Abhydrolase_6,Peptidase_S9 MMS2_k127_1942672_4 338969.Rfer_0277 4.935e-124 404.0 COG0702@1|root,COG0702@2|Bacteria,1MW44@1224|Proteobacteria,2VM5Q@28216|Betaproteobacteria,4AF0N@80864|Comamonadaceae 28216|Betaproteobacteria GM NmrA-like family - - 1.6.5.2 ko:K19267 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - NAD_binding_10,NmrA MMS2_k127_1942672_10 987059.RBXJA2T_04868 8.248e-57 200.0 COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2VSXJ@28216|Betaproteobacteria,1KMGI@119065|unclassified Burkholderiales 28216|Betaproteobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR MMS2_k127_1942672_3 1165841.SULAR_03053 8.774e-138 443.0 COG2191@1|root,COG2191@2|Bacteria,1NX7R@1224|Proteobacteria,430UJ@68525|delta/epsilon subdivisions 1224|Proteobacteria C FmdE, Molybdenum formylmethanofuran dehydrogenase operon - - - - - - - - - - - - FmdE MMS2_k127_1942672_2 1396858.Q666_03000 1.455e-150 484.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,1RQSE@1236|Gammaproteobacteria,46661@72275|Alteromonadaceae 1236|Gammaproteobacteria V ABC-type multidrug transport system, permease component yhhJ - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 MMS2_k127_1942672_0 626887.J057_17560 0.0 1215.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,1T1GD@1236|Gammaproteobacteria,465Q1@72275|Alteromonadaceae 1236|Gammaproteobacteria V ABC-type multidrug transport system, ATPase component - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran MMS2_k127_1942672_5 283699.D172_0578 1.14e-102 344.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,1T2MP@1236|Gammaproteobacteria,2Q26A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V Biotin-lipoyl like - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 MMS2_k127_1942672_1 795666.MW7_0549 9.212e-239 750.0 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,2VHSM@28216|Betaproteobacteria,1KIDV@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family rosB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N MMS2_k127_1942672_8 379731.PST_2698 2.265e-76 261.0 COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S42B@1236|Gammaproteobacteria,1Z1MN@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 MMS2_k127_1942672_11 674977.VMC_00060 1.467e-48 190.0 COG2890@1|root,COG2890@2|Bacteria 2|Bacteria J protein-(glutamine-N5) methyltransferase activity - - - - - - - - - - - - Methyltransf_25,Methyltransf_32 MMS2_k127_1942672_6 258594.RPA2722 1.321e-83 282.0 COG1051@1|root,COG1051@2|Bacteria,1RH0I@1224|Proteobacteria,2UB84@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Hydrolase of X-linked nucleoside diphosphate N terminal - - - - - - - - - - - - NUDIX,Nudix_N MMS2_k127_1942672_12 62928.azo2304 9.867e-38 146.0 COG0789@1|root,COG0789@2|Bacteria,1MWN0@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator mta_1 - - ko:K19591,ko:K21744 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR_1,TipAS MMS2_k127_1950997_1 1234364.AMSF01000024_gene3846 1.18e-17 84.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1X72K@135614|Xanthomonadales 135614|Xanthomonadales S YGGT family - - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT MMS2_k127_1950997_2 1384054.N790_07735 2.685e-13 79.0 2DP15@1|root,3303T@2|Bacteria,1N7NN@1224|Proteobacteria,1S90P@1236|Gammaproteobacteria,1X82G@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4426) - - - - - - - - - - - - DUF4426 MMS2_k127_1950997_0 1123073.KB899241_gene1754 1.077e-100 331.0 COG0614@1|root,COG0614@2|Bacteria,1PK1A@1224|Proteobacteria,1RRDK@1236|Gammaproteobacteria,1X3UZ@135614|Xanthomonadales 135614|Xanthomonadales P ABC transporter substrate-binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 MMS2_k127_1955101_3 999541.bgla_2g09190 5.817e-17 81.0 COG0346@1|root,COG0346@2|Bacteria,1MUBT@1224|Proteobacteria,2W9SY@28216|Betaproteobacteria,1K62I@119060|Burkholderiaceae 28216|Betaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase MMS2_k127_1955101_1 663610.JQKO01000004_gene2796 3.739e-37 149.0 COG2845@1|root,COG2845@2|Bacteria,1R4X7@1224|Proteobacteria,2U5AU@28211|Alphaproteobacteria,3NASZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF459) - - - ko:K09795 - - - - ko00000 - - - DUF459 MMS2_k127_1955101_0 1333998.M2A_2226 5.843e-155 503.0 COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2TRD1@28211|Alphaproteobacteria,4BRR5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M MBOAT, membrane-bound O-acyltransferase family algI - - - - - - - - - - - MBOAT MMS2_k127_1955101_2 648757.Rvan_3294 2.876e-33 134.0 COG2928@1|root,COG2928@2|Bacteria,1PZ1I@1224|Proteobacteria,2V734@28211|Alphaproteobacteria,3N8W5@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 MMS2_k127_196846_1 1283300.ATXB01000001_gene1198 6.764e-192 610.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1XEPE@135618|Methylococcales 135618|Methylococcales L DNA photolyase - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 MMS2_k127_196846_3 555778.Hneap_2226 5.737e-48 177.0 COG2033@1|root,COG2033@2|Bacteria,1N615@1224|Proteobacteria,1SBN9@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Desulfoferrodoxin - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrodox MMS2_k127_196846_4 391626.OAN307_c38260 1.499e-23 108.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2TSHG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S unusual protein kinase - - - - - - - - - - - - ABC1 MMS2_k127_196846_2 305700.B447_11947 2.942e-88 308.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,2VMKW@28216|Betaproteobacteria,2KYIB@206389|Rhodocyclales 206389|Rhodocyclales S ABC1 family - - - - - - - - - - - - ABC1 MMS2_k127_196846_0 1304275.C41B8_17431 8.957e-218 692.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1S04I@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Heavy metal translocating P-type atpase - - - - - - - - - - - - E1-E2_ATPase,Hemerythrin,Hydrolase MMS2_k127_1988670_3 768671.ThimaDRAFT_2505 2.878e-86 291.0 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RP6J@1236|Gammaproteobacteria,1X2FB@135613|Chromatiales 135613|Chromatiales Q Isochorismatase family - - - - - - - - - - - - Isochorismatase MMS2_k127_1988670_5 644966.Tmar_1828 9.584e-54 200.0 COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,3WCKK@538999|Clostridiales incertae sedis 186801|Clostridia S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 MMS2_k127_1988670_4 1089552.KI911559_gene2091 9.864e-79 267.0 COG3470@1|root,COG3470@2|Bacteria,1RA2Z@1224|Proteobacteria,2U8J6@28211|Alphaproteobacteria,2JSTQ@204441|Rhodospirillales 204441|Rhodospirillales P protein probably involved in high-affinity Fe2 transport - - - ko:K07230 - - - - ko00000,ko02000 2.A.108.2.10,2.A.108.2.4,2.A.108.2.9 - - Iron_transport MMS2_k127_1988670_0 1089552.KI911559_gene2092 2.338e-184 589.0 COG0348@1|root,COG0348@2|Bacteria,1N605@1224|Proteobacteria,2U33K@28211|Alphaproteobacteria,2JSEW@204441|Rhodospirillales 204441|Rhodospirillales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4_5 MMS2_k127_1988670_2 1089552.KI911559_gene2093 3.707e-110 362.0 COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2TU8Z@28211|Alphaproteobacteria,2JRT0@204441|Rhodospirillales 204441|Rhodospirillales P Iron permease FTR1 family - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 MMS2_k127_1988670_6 1089552.KI911559_gene2094 6.815e-35 138.0 COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,2UFK9@28211|Alphaproteobacteria,2JUAG@204441|Rhodospirillales 204441|Rhodospirillales S Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 MMS2_k127_1988670_1 1279019.ARQK01000040_gene364 1.562e-131 425.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1WWM6@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate MMS2_k127_1988670_7 1380394.JADL01000008_gene3675 1.04e-19 94.0 COG3420@1|root,COG3420@2|Bacteria,1R5QH@1224|Proteobacteria,2U3Y9@28211|Alphaproteobacteria,2JSRP@204441|Rhodospirillales 204441|Rhodospirillales P Parallel beta-helix repeats - - - - - - - - - - - - Beta_helix MMS2_k127_2023733_2 926566.Terro_0915 4.788e-15 83.0 2CGTC@1|root,331SF@2|Bacteria,3Y7P6@57723|Acidobacteria,2JMRK@204432|Acidobacteriia 204432|Acidobacteriia S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 MMS2_k127_2023733_1 1207076.ALAT01000022_gene9 8.25e-93 312.0 COG2186@1|root,COG2186@2|Bacteria,1R8M2@1224|Proteobacteria,1RZIJ@1236|Gammaproteobacteria,1Z114@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K COG2186 Transcriptional regulators glcC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K05799,ko:K11474 - - - - ko00000,ko03000 - - - FCD,GntR MMS2_k127_2023733_0 1301098.PKB_5685 1.945e-232 725.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Fad linked oxidase glcD GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750 FAD-oxidase_C,FAD_binding_4 MMS2_k127_2023815_12 870187.Thini_2193 2.196e-22 99.0 COG0633@1|root,COG1018@1|root,COG0633@2|Bacteria,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1RRXH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C oxidoreductase, FAD - - - - - - - - - - - - FAD_binding_6,Fer2,NAD_binding_1 MMS2_k127_2023815_1 870187.Thini_2192 5.239e-294 911.0 COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,1RP1I@1236|Gammaproteobacteria,461KI@72273|Thiotrichales 72273|Thiotrichales P Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane MMS2_k127_2023815_0 765911.Thivi_1686 0.0 1080.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,1RMBA@1236|Gammaproteobacteria,1WWZR@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation metE - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_1,Meth_synt_2 MMS2_k127_2023815_3 765911.Thivi_1685 8.129e-107 354.0 COG0583@1|root,COG0583@2|Bacteria,1MUIX@1224|Proteobacteria,1RRF3@1236|Gammaproteobacteria,1WXTB@135613|Chromatiales 135613|Chromatiales K LysR family - - - ko:K03576 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate MMS2_k127_2023815_15 999411.HMPREF1092_01340 4.095e-08 60.0 COG1846@1|root,COG1846@2|Bacteria,1V6EE@1239|Firmicutes,24KTN@186801|Clostridia,36HZU@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - ko:K15973 - - - - ko00000,ko03000 - - - MarR MMS2_k127_2023815_10 926550.CLDAP_30490 2.843e-35 141.0 COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi 200795|Chloroflexi S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 MMS2_k127_2023815_11 1430440.MGMSRv2_0382 4.331e-35 150.0 COG1296@1|root,COG1296@2|Bacteria,1P6U3@1224|Proteobacteria,2V9EK@28211|Alphaproteobacteria,2JU7Y@204441|Rhodospirillales 204441|Rhodospirillales E AzlC protein - - - - - - - - - - - - AzlC MMS2_k127_2023815_9 1265502.KB905955_gene465 2.376e-46 188.0 COG0500@1|root,COG1396@1|root,COG0500@2|Bacteria,COG1396@2|Bacteria,1MXWB@1224|Proteobacteria,2WFBC@28216|Betaproteobacteria,4AG4E@80864|Comamonadaceae 28216|Betaproteobacteria K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 MMS2_k127_2023815_14 187272.Mlg_1202 2.105e-11 74.0 COG3218@1|root,COG3218@2|Bacteria,1NNSH@1224|Proteobacteria 1224|Proteobacteria S transport system auxiliary component - - - ko:K18480 - M00669 - - ko00000,ko00002,ko02000 3.A.1.27.1 - - ABC_trans_aux MMS2_k127_2023815_8 748247.AZKH_p0369 1.029e-53 200.0 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2VJHA@28216|Betaproteobacteria,2KWAS@206389|Rhodocyclales 28216|Betaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD MMS2_k127_2023815_7 187272.Mlg_1204 4.685e-76 274.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S2T9@1236|Gammaproteobacteria,1WY3B@135613|Chromatiales 135613|Chromatiales P PFAM ABC transporter related - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran MMS2_k127_2023815_5 472759.Nhal_0469 6.273e-98 331.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1WXIV@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 MMS2_k127_2023815_6 1122603.ATVI01000005_gene3528 2.022e-92 313.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RXZ5@1236|Gammaproteobacteria,1X4RH@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator rbcR - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2023815_2 870187.Thini_3645 2.953e-253 786.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,4601D@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase MMS2_k127_2023815_4 519989.ECTPHS_11100 8.892e-106 346.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales 135613|Chromatiales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C MMS2_k127_2023815_13 1408418.JNJH01000007_gene1384 3.999e-13 70.0 COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,2JTIA@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_2031449_1 95619.PM1_0227460 1.031e-88 298.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,1RQP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2031449_2 240292.Ava_0113 5.637e-56 202.0 COG0637@1|root,COG0637@2|Bacteria,1G7W5@1117|Cyanobacteria 1117|Cyanobacteria S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 MMS2_k127_2031449_0 69395.JQLZ01000001_gene3245 1.54e-132 430.0 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2TU9J@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2040198_5 555778.Hneap_0797 8.86e-117 379.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,1RR1E@1236|Gammaproteobacteria,1WW97@135613|Chromatiales 135613|Chromatiales S TIGRFAM Urea carboxylase-associated protein 1 - - - ko:K09967 - - - - ko00000 - - - DUF1989 MMS2_k127_2040198_2 555778.Hneap_0796 1.06e-130 419.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,1WY7K@135613|Chromatiales 135613|Chromatiales S TIGRFAM Urea carboxylase-associated protein 2 - - - ko:K09967 - - - - ko00000 - - - DUF1989 MMS2_k127_2040198_7 1168067.JAGP01000001_gene1682 9.293e-112 368.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria 1236|Gammaproteobacteria P (ABC) transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran MMS2_k127_2040198_8 686340.Metal_0583 6.934e-107 353.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,1RQ0A@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 MMS2_k127_2040198_1 1158292.JPOE01000005_gene1363 2.731e-131 426.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2VNH6@28216|Betaproteobacteria,1KMUX@119065|unclassified Burkholderiales 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051,ko:K15553 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - NMT1 MMS2_k127_2040198_0 187272.Mlg_1152 2.467e-143 470.0 COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,1RQXQ@1236|Gammaproteobacteria,1WWUC@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal MMS2_k127_2040198_12 1026882.MAMP_02086 7.533e-91 308.0 COG0697@1|root,COG0697@2|Bacteria,1R6CU@1224|Proteobacteria,1SZQJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_2040198_9 1288826.MSNKSG1_02038 2.515e-106 352.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1SZJQ@1236|Gammaproteobacteria,467NX@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2040198_16 635013.TherJR_0913 1.389e-64 228.0 COG0518@1|root,COG0518@2|Bacteria,1UAH0@1239|Firmicutes,24DR4@186801|Clostridia,261SI@186807|Peptococcaceae 186801|Clostridia F PFAM Glutamine amidotransferase class-I - - - - - - - - - - - - GATase MMS2_k127_2040198_15 426114.THI_3654 3.525e-73 259.0 COG0697@1|root,COG0697@2|Bacteria,1RBFV@1224|Proteobacteria,2VQEZ@28216|Betaproteobacteria 28216|Betaproteobacteria EG of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA MMS2_k127_2040198_17 1437882.AZRU01000027_gene823 4.549e-37 158.0 294MD@1|root,2ZS0U@2|Bacteria,1RE2W@1224|Proteobacteria,1SZS7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2040198_3 1168067.JAGP01000001_gene592 1.525e-125 409.0 COG0491@1|root,COG0491@2|Bacteria,1PHBX@1224|Proteobacteria,1S357@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metallo-beta-lactamase superfamily - - 3.1.1.81 ko:K13075 ko02024,map02024 - R08970 RC00713 ko00000,ko00001,ko01000 - - - Lactamase_B MMS2_k127_2040198_14 1166948.JPZL01000004_gene140 1.462e-82 288.0 COG1028@1|root,COG1028@2|Bacteria,1R48C@1224|Proteobacteria,1SPF8@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 MMS2_k127_2040198_13 1301098.PKB_2171 3.654e-86 289.0 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,1RU8R@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Amidases related to nicotinamidase - - - - - - - - - - - - Isochorismatase MMS2_k127_2040198_6 1301098.PKB_2172 2.601e-115 376.0 COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,1SITE@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase MMS2_k127_2040198_10 426114.THI_3653 5.19e-99 328.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1KNH5@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ KR domain - - 1.1.1.100,1.1.1.47,1.1.1.69,1.3.1.28 ko:K00034,ko:K00046,ko:K00059,ko:K00216 ko00030,ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01120,map01130,map01200,map01212 M00083,M00572 R01505,R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00066,RC00117,RC00534 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 MMS2_k127_2040198_4 1158292.JPOE01000005_gene1376 1.268e-118 392.0 COG3239@1|root,COG3239@2|Bacteria,1P79B@1224|Proteobacteria,2W0MI@28216|Betaproteobacteria 28216|Betaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase MMS2_k127_2040198_11 426114.THI_3650 7.766e-99 333.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2VNH6@28216|Betaproteobacteria,1KMUX@119065|unclassified Burkholderiales 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051,ko:K15553 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - NMT1 MMS2_k127_2054422_8 713586.KB900536_gene3091 3.561e-54 197.0 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1WXZ8@135613|Chromatiales 135613|Chromatiales FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam MMS2_k127_2054422_3 1005048.CFU_1533 6.733e-196 616.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VHH9@28216|Betaproteobacteria,474CW@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red MMS2_k127_2054422_0 396588.Tgr7_1036 3.166e-297 917.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase MMS2_k127_2054422_1 396588.Tgr7_1035 1.991e-254 792.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH MMS2_k127_2054422_4 396588.Tgr7_1034 6.038e-146 477.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1WWPS@135613|Chromatiales 135613|Chromatiales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 MMS2_k127_2054422_6 1183438.GKIL_2979 1.397e-100 334.0 COG0637@1|root,COG0637@2|Bacteria,1G2T2@1117|Cyanobacteria 1117|Cyanobacteria S TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - - - - - - - - - - - HAD_2 MMS2_k127_2054422_7 396588.Tgr7_1032 5.041e-58 222.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1WXYW@135613|Chromatiales 135613|Chromatiales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR MMS2_k127_2054422_5 582744.Msip34_1144 3.722e-105 351.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KM5R@206350|Nitrosomonadales 206350|Nitrosomonadales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c MMS2_k127_2054422_2 472759.Nhal_2695 2.267e-253 788.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C MMS2_k127_2062101_9 713586.KB900536_gene1264 1.144e-29 118.0 COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutamine amidotransferase egtC - - - - - - - - - - - GATase_4 MMS2_k127_2062101_0 1234364.AMSF01000015_gene3343 2.815e-197 627.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1X3KT@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase MMS2_k127_2062101_4 1288298.rosmuc_02465 7.298e-59 210.0 COG0454@1|root,COG0456@2|Bacteria,1QUWI@1224|Proteobacteria,2TXQV@28211|Alphaproteobacteria,46PX7@74030|Roseovarius 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2062101_10 472759.Nhal_2885 1.405e-09 61.0 COG1670@1|root,COG1670@2|Bacteria 2|Bacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins natSF - 2.3.1.102,2.3.1.128 ko:K03789,ko:K03790,ko:K03896 ko00310,ko01120,map00310,map01120 - R03168 RC00004,RC00865 ko00000,ko00001,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_3 MMS2_k127_2062101_3 1163617.SCD_n02330 1.653e-66 231.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2VSHT@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF924 MMS2_k127_2062101_1 1255043.TVNIR_2188 2.001e-157 507.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WXP9@135613|Chromatiales 135613|Chromatiales M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS MMS2_k127_2062101_7 1158292.JPOE01000002_gene3294 8.681e-46 171.0 COG3193@1|root,COG3193@2|Bacteria,1REZG@1224|Proteobacteria,2VUGP@28216|Betaproteobacteria 28216|Betaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading MMS2_k127_2062101_6 519989.ECTPHS_08958 1.597e-47 175.0 2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria,1WYGK@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF1841) - - - - - - - - - - - - DUF1841 MMS2_k127_2062101_5 396588.Tgr7_2643 5.076e-56 204.0 2DX2X@1|root,32V2M@2|Bacteria,1MZZC@1224|Proteobacteria,1S4WN@1236|Gammaproteobacteria,1WYAX@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_2062101_2 765912.Thimo_2637 3.925e-80 269.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,1RRM7@1236|Gammaproteobacteria,1X23M@135613|Chromatiales 135613|Chromatiales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 MMS2_k127_2062101_8 309807.SRU_0869 1.072e-41 160.0 2CBKC@1|root,32RTJ@2|Bacteria,4NTE7@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - MMS2_k127_2080702_2 396588.Tgr7_0658 2.354e-22 96.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family csgA - - - - - - - - - - - adh_short MMS2_k127_2080702_0 1123368.AUIS01000023_gene933 9.318e-141 480.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales 225057|Acidithiobacillales T Diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GGDEF,PAS,PAS_4 MMS2_k127_2080702_1 1158762.KB898039_gene1809 1.809e-112 396.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXQS@135613|Chromatiales 135613|Chromatiales T Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_4,PAS_9 MMS2_k127_2080702_3 1260251.SPISAL_07775 1.183e-05 49.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK MMS2_k127_2128824_2 290315.Clim_1279 6.865e-84 291.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity hrtA - - ko:K02003,ko:K09814 ko02010,map02010 M00257,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 - - ABC_tran MMS2_k127_2128824_1 290315.Clim_1280 2.738e-148 482.0 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - MacB_PCD MMS2_k127_2128824_3 290315.Clim_1281 1.141e-52 200.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 MMS2_k127_2128824_0 555778.Hneap_2282 0.0 1188.0 COG0834@1|root,COG2206@1|root,COG3437@1|root,COG0834@2|Bacteria,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,1RM9C@1236|Gammaproteobacteria,1WZW2@135613|Chromatiales 135613|Chromatiales T HD domain - - - - - - - - - - - - GAF,GAF_2,HD_5 MMS2_k127_2133850_0 649638.Trad_2292 3.057e-232 732.0 COG2407@1|root,COG2407@2|Bacteria,1WKXP@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - - MMS2_k127_2133850_1 937777.Deipe_1361 3.196e-207 661.0 COG1070@1|root,COG1070@2|Bacteria,1WITI@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N MMS2_k127_2133850_5 570967.JMLV01000002_gene1822 1.391e-40 172.0 COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2U5II@28211|Alphaproteobacteria,2JS58@204441|Rhodospirillales 204441|Rhodospirillales S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom MMS2_k127_2133850_2 713586.KB900536_gene2019 1.108e-186 604.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria,1WXT5@135613|Chromatiales 135613|Chromatiales C LUD domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom MMS2_k127_2133850_3 935840.JAEQ01000007_gene3828 6.152e-114 376.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,43JAC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG MMS2_k127_2133850_4 870187.Thini_2219 3.346e-74 255.0 COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,1S8DJ@1236|Gammaproteobacteria,463PP@72273|Thiotrichales 72273|Thiotrichales O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C,GST_N MMS2_k127_2133850_6 592316.Pat9b_1837 9.648e-20 94.0 2AFQE@1|root,315S9@2|Bacteria,1RHHZ@1224|Proteobacteria,1S7HB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2147296_5 713586.KB900536_gene76 1.732e-133 436.0 COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales 135613|Chromatiales EGP Major facilitator superfamily - - - ko:K05820 - - - - ko00000,ko02000 2.A.1.27 - - MFS_1_like MMS2_k127_2147296_7 29495.EA26_01170 2.1e-69 246.0 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1XSBI@135623|Vibrionales 135623|Vibrionales H Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ MMS2_k127_2147296_4 396588.Tgr7_1241 1.684e-193 611.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales 135613|Chromatiales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt MMS2_k127_2147296_0 555778.Hneap_1179 3.136e-246 775.0 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria,1WWXJ@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2,ABC_tran MMS2_k127_2147296_10 426114.THI_0897 2.297e-43 172.0 COG1651@1|root,COG1651@2|Bacteria,1NEFD@1224|Proteobacteria,2VKFR@28216|Betaproteobacteria 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbG - - ko:K03805 - - - - ko00000,ko03110 - - - Thioredoxin_2 MMS2_k127_2147296_2 1385517.N800_04575 1.506e-205 646.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1X3V0@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family vipA - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N MMS2_k127_2147296_3 1158762.KB898038_gene1964 1.358e-193 609.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales 135613|Chromatiales M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd MMS2_k127_2147296_12 396588.Tgr7_0223 1.339e-17 89.0 COG1716@1|root,COG1716@2|Bacteria,1QZZ7@1224|Proteobacteria,1T4CF@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Forkhead associated domain - - - - - - - - - - - - FHA MMS2_k127_2147296_6 748280.NH8B_3704 8.578e-112 373.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2VJET@28216|Betaproteobacteria,2KQU0@206351|Neisseriales 206351|Neisseriales M Glycosyltransferase Family 4 - - - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1 MMS2_k127_2147296_11 156889.Mmc1_3365 2.505e-34 141.0 COG2932@1|root,COG2932@2|Bacteria,1N97M@1224|Proteobacteria,2UF88@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_3,Peptidase_S24 MMS2_k127_2147296_13 202952.BBLI01000008_gene828 4.561e-09 58.0 2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2147296_14 1216007.AOPM01000086_gene856 1.257e-08 60.0 2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria,1SHSY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2147296_1 396588.Tgr7_1579 4.742e-227 711.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1WW94@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c MMS2_k127_2147296_8 396588.Tgr7_1565 3.593e-68 235.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales 135613|Chromatiales I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA MMS2_k127_2147296_9 1049564.TevJSym_ad00720 1.428e-46 173.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1J5B5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C MMS2_k127_2175486_15 1026882.MAMP_01441 1.009e-63 224.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,460ER@72273|Thiotrichales 72273|Thiotrichales T Chemotaxis protein - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg MMS2_k127_2175486_12 396588.Tgr7_2694 1.844e-79 280.0 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1WXU4@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD MMS2_k127_2175486_23 519989.ECTPHS_04573 1.543e-21 107.0 COG3144@1|root,COG3144@2|Bacteria,1MV22@1224|Proteobacteria 1224|Proteobacteria N flagellar hook-length control protein FliK - - - - - - - - - - - - Flg_hook MMS2_k127_2175486_21 396588.Tgr7_1350 6.683e-27 117.0 COG2257@1|root,COG2257@2|Bacteria,1N7F1@1224|Proteobacteria,1SCWV@1236|Gammaproteobacteria,1WYU0@135613|Chromatiales 135613|Chromatiales S cytoplasmic domain of flagellar protein - - - ko:K04061 - - - - ko00000,ko02044 - - - Bac_export_2 MMS2_k127_2175486_25 396588.Tgr7_1349 6.586e-05 51.0 2ER47@1|root,33IPS@2|Bacteria,1NHAY@1224|Proteobacteria,1SH4T@1236|Gammaproteobacteria 1236|Gammaproteobacteria S chemotaxis, protein - - - - - - - - - - - - DUF2802 MMS2_k127_2175486_17 396588.Tgr7_1347 2.257e-54 194.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1SYDF@1236|Gammaproteobacteria,1WXZ3@135613|Chromatiales 135613|Chromatiales NT PFAM CheW domain protein - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW MMS2_k127_2175486_19 187272.Mlg_0991 9.07e-41 159.0 COG0835@1|root,COG0835@2|Bacteria,1MYHY@1224|Proteobacteria,1S2TC@1236|Gammaproteobacteria,1X10Q@135613|Chromatiales 135613|Chromatiales NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW MMS2_k127_2175486_6 748658.KB907317_gene295 3.165e-99 333.0 COG1192@1|root,COG1192@2|Bacteria,1MWSE@1224|Proteobacteria,1RQ3X@1236|Gammaproteobacteria,1WXRP@135613|Chromatiales 135613|Chromatiales D PFAM Cobyrinic acid a,c-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 MMS2_k127_2175486_14 396588.Tgr7_1344 8.579e-73 261.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1S294@1236|Gammaproteobacteria,1WWE9@135613|Chromatiales 135613|Chromatiales N PFAM OmpA MotB domain protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA MMS2_k127_2175486_8 1357272.AVEO02000177_gene3041 7.555e-95 316.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNWB@1236|Gammaproteobacteria,1Z61F@136849|Pseudomonas syringae group 1236|Gammaproteobacteria N MotA/TolQ/ExbB proton channel family motC - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB MMS2_k127_2175486_3 396588.Tgr7_1342 4.387e-127 415.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1WWSE@135613|Chromatiales 135613|Chromatiales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg MMS2_k127_2175486_1 1429851.X548_08170 2.928e-168 551.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3YM@135614|Xanthomonadales 135614|Xanthomonadales NT chemotaxis protein cheA2 - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt MMS2_k127_2175486_13 396588.Tgr7_1340 7.303e-76 262.0 COG3143@1|root,COG3143@2|Bacteria,1NIV6@1224|Proteobacteria,1RNG2@1236|Gammaproteobacteria,1WWSX@135613|Chromatiales 135613|Chromatiales NT Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) - - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ MMS2_k127_2175486_16 545264.KB898745_gene1115 2.184e-61 214.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,1S47I@1236|Gammaproteobacteria,1WYA4@135613|Chromatiales 135613|Chromatiales KT response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg MMS2_k127_2175486_10 396588.Tgr7_1338 4.16e-88 298.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1WXKN@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 MMS2_k127_2175486_5 396588.Tgr7_1337 6.051e-116 382.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,1RMZ2@1236|Gammaproteobacteria,1WWDH@135613|Chromatiales 135613|Chromatiales D Belongs to the ParA family - - - ko:K04562 - - - - ko00000,ko02035 - - - CbiA,ParA MMS2_k127_2175486_7 396588.Tgr7_1336 1.512e-98 336.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1WXF1@135613|Chromatiales 135613|Chromatiales N PFAM GTP-binding signal recognition particle SRP54 G- domain - - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 MMS2_k127_2175486_0 396588.Tgr7_1335 4.801e-310 963.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1WVWU@135613|Chromatiales 135613|Chromatiales N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP MMS2_k127_2175486_4 396588.Tgr7_1334 1.082e-116 386.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,1WW1K@135613|Chromatiales 135613|Chromatiales N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 MMS2_k127_2175486_11 396588.Tgr7_1333 1.022e-81 279.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1WWVK@135613|Chromatiales 135613|Chromatiales N Role in flagellar biosynthesis - - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 MMS2_k127_2175486_22 396588.Tgr7_1332 4.276e-26 110.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,1SCBG@1236|Gammaproteobacteria,1WYWJ@135613|Chromatiales 135613|Chromatiales NU Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 MMS2_k127_2175486_9 754476.Q7A_2938 7.533e-91 308.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,1RMYH@1236|Gammaproteobacteria,46081@72273|Thiotrichales 72273|Thiotrichales N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP MMS2_k127_2175486_24 519989.ECTPHS_04678 1.096e-20 101.0 COG3190@1|root,COG3190@2|Bacteria 2|Bacteria N flagellar fliO - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO MMS2_k127_2175486_18 396588.Tgr7_1329 1.321e-45 169.0 COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,1S5YE@1236|Gammaproteobacteria,1WZ2M@135613|Chromatiales 135613|Chromatiales N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation - - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C MMS2_k127_2175486_2 396588.Tgr7_1328 4.885e-149 477.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1WWMX@135613|Chromatiales 135613|Chromatiales N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation - - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C MMS2_k127_2175486_20 1415778.JQMM01000001_gene1350 3.63e-32 132.0 COG1580@1|root,COG1580@2|Bacteria,1N2N9@1224|Proteobacteria,1SAF0@1236|Gammaproteobacteria,1J6I3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL MMS2_k127_2225012_2 580332.Slit_1379 4.115e-12 67.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Appr-1-p processing domain protein ymdB - - - - - - - - - - - Macro MMS2_k127_2225012_1 360910.BAV2948 3.753e-69 243.0 COG3271@1|root,COG3271@2|Bacteria,1RE7B@1224|Proteobacteria,2W3ZZ@28216|Betaproteobacteria,3T7DY@506|Alcaligenaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - Peptidase_C39_2 MMS2_k127_2225012_0 879212.DespoDRAFT_01066 1.912e-108 358.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,42NHY@68525|delta/epsilon subdivisions,2WKAP@28221|Deltaproteobacteria,2MK6K@213118|Desulfobacterales 28221|Deltaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase ghr - 1.1.1.31,1.1.1.60,1.1.1.79 ko:K00020,ko:K00042,ko:K18121 ko00280,ko00630,ko00650,ko01100,ko01120,ko01200,map00280,map00630,map00650,map01100,map01120,map01200 - R00465,R01745,R01747,R05066,R09281 RC00042,RC00087,RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 MMS2_k127_2244553_2 748658.KB907318_gene984 1.579e-13 79.0 COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1SFI0@1236|Gammaproteobacteria,1WY1U@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 MMS2_k127_2244553_0 396588.Tgr7_1407 1.076e-256 813.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H MMS2_k127_2244553_1 713586.KB900536_gene634 7.129e-162 525.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales 135613|Chromatiales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH MMS2_k127_22456_1 318167.Sfri_0051 7.988e-50 179.0 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,1RYH6@1236|Gammaproteobacteria,2Q8N4@267890|Shewanellaceae 1236|Gammaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ MMS2_k127_22456_0 2340.JV46_12870 7.589e-110 369.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,1JB29@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like MMS2_k127_22456_2 366394.Smed_5497 2.049e-39 152.0 28NIR@1|root,2ZBK2@2|Bacteria,1RAAF@1224|Proteobacteria,2U5XR@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_226091_3 1266914.ATUK01000010_gene1264 4.739e-29 120.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn MMS2_k127_226091_0 596151.DesfrDRAFT_0728 1.207e-290 917.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WJ6F@28221|Deltaproteobacteria,2MG23@213115|Desulfovibrionales 28221|Deltaproteobacteria G PEP-utilising enzyme, N-terminal - - 2.7.1.202,2.7.3.9 ko:K02768,ko:K08483,ko:K11183 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2 MMS2_k127_226091_1 522306.CAP2UW1_2060 6.944e-84 288.0 COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,2VPIP@28216|Betaproteobacteria 28216|Betaproteobacteria H belongs to the carbohydrate kinase PfkB family fruK - 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB MMS2_k127_226091_2 1051632.TPY_2419 1.048e-29 121.0 COG1299@1|root,COG1445@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,1TPKU@1239|Firmicutes,248V6@186801|Clostridia 186801|Clostridia G Phosphotransferase System fruA - 2.7.1.202 ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIC,PTS_IIB MMS2_k127_2296903_10 316056.RPC_0776 7.301e-34 133.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2U0HE@28211|Alphaproteobacteria,3JUPV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E LysE type translocator MA20_06410 - - - - - - - - - - - LysE MMS2_k127_2296903_5 323850.Shew_3211 1.573e-88 296.0 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,2QB3U@267890|Shewanellaceae 1236|Gammaproteobacteria O Glutathione S-transferase, C-terminal domain gst5 - 2.5.1.18 ko:K00799,ko:K11209 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 MMS2_k127_2296903_8 614083.AWQR01000048_gene3227 4.172e-45 168.0 COG0454@1|root,COG0456@2|Bacteria,1RIU4@1224|Proteobacteria,2W38U@28216|Betaproteobacteria 28216|Betaproteobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2296903_3 1390370.O203_02205 1.241e-93 311.0 COG1280@1|root,COG1280@2|Bacteria,1RJK2@1224|Proteobacteria,1S7S6@1236|Gammaproteobacteria,1YFX4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE MMS2_k127_2296903_1 1286631.X805_27950 1.311e-196 621.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,1KISX@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Tryptophanyl-tRNA synthetase trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF1508,tRNA-synt_1b MMS2_k127_2296903_7 67281.JNZZ01000059_gene599 1.193e-63 229.0 COG0596@1|root,COG0596@2|Bacteria,2HD4C@201174|Actinobacteria,419YT@629295|Streptomyces griseus group 201174|Actinobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6 MMS2_k127_2296903_0 1112212.JH584235_gene3079 4.31e-294 906.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2TQYS@28211|Alphaproteobacteria,2K0X0@204457|Sphingomonadales 204457|Sphingomonadales C acetyl-CoA hydrolase - - 2.8.3.18 ko:K18118 ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R10343 RC00012,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro MMS2_k127_2296903_6 66869.JNXG01000010_gene584 3.059e-71 244.0 COG2258@1|root,COG2258@2|Bacteria,2GMBE@201174|Actinobacteria,41CA4@629295|Streptomyces griseus group 201174|Actinobacteria S MOSC domain - - - - - - - - - - - - MOSC MMS2_k127_2296903_4 768671.ThimaDRAFT_0347 2.306e-90 306.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1WWTZ@135613|Chromatiales 135613|Chromatiales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 MMS2_k127_2296903_2 1123256.KB907926_gene893 4.139e-97 327.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales 135614|Xanthomonadales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK MMS2_k127_2296903_9 396588.Tgr7_1372 9.671e-45 168.0 2CCMG@1|root,33UCX@2|Bacteria,1NUGG@1224|Proteobacteria,1SNT7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Glycos_transf_N MMS2_k127_2298559_13 889378.Spiaf_1317 2.177e-05 48.0 COG2199@1|root,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GAF,GGDEF,PAS,PAS_4,PAS_8,PAS_9,Response_reg MMS2_k127_2298559_10 29581.BW37_04677 5.511e-15 79.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472RR@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM EAL domain, GGDEF domain - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_4,PAS_9 MMS2_k127_2298559_6 395493.BegalDRAFT_3254 5.143e-51 194.0 COG0742@1|root,COG0742@2|Bacteria,1MX8Z@1224|Proteobacteria,1RMIB@1236|Gammaproteobacteria,460MG@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the guanosine in position 1516 of 16S rRNA rsmJ - 2.1.1.242 ko:K15984 - - - - ko00000,ko01000,ko03009 - - - SAM_MT MMS2_k127_2298559_9 1266914.ATUK01000013_gene1720 1.722e-34 135.0 2E0T4@1|root,32WAV@2|Bacteria,1N19Z@1224|Proteobacteria,1SBDA@1236|Gammaproteobacteria,1WZ0Q@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_2298559_5 765914.ThisiDRAFT_0397 6.449e-57 205.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1WXZ5@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0234 family - - - ko:K09767 - - - - ko00000 - - - DUF520 MMS2_k127_2298559_8 1128421.JAGA01000001_gene2006 1.501e-34 136.0 COG2363@1|root,COG2363@2|Bacteria,2NRMS@2323|unclassified Bacteria 2|Bacteria S Protein of unknown function (DUF423) ywdK - - - - - - - - - - - DUF423 MMS2_k127_2298559_7 713586.KB900536_gene105 9.608e-39 148.0 COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,1S5UP@1236|Gammaproteobacteria,1X1RY@135613|Chromatiales 135613|Chromatiales P Frataxin-like domain cyaY - - ko:K06202 - - - - ko00000 - - - Frataxin_Cyay MMS2_k127_2298559_4 998674.ATTE01000001_gene1725 3.982e-73 256.0 COG0639@1|root,COG0639@2|Bacteria,1N106@1224|Proteobacteria,1S9QJ@1236|Gammaproteobacteria,462QI@72273|Thiotrichales 72273|Thiotrichales T Calcineurin-like phosphoesterase - - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos MMS2_k127_2298559_2 1207063.P24_15911 3.138e-124 412.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2TSRR@28211|Alphaproteobacteria,2JPT5@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus MMS2_k127_2298559_0 519989.ECTPHS_03387 2.244e-162 523.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,1RNFI@1236|Gammaproteobacteria,1X2F6@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3663,Peptidase_M17 MMS2_k127_2298559_1 713586.KB900536_gene753 5.191e-132 428.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_2298559_3 765912.Thimo_2102 1.815e-109 359.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales 135613|Chromatiales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane MMS2_k127_2306834_1 75379.Tint_1236 2.46e-65 238.0 COG0840@1|root,COG0840@2|Bacteria,1NCMF@1224|Proteobacteria,2VJC0@28216|Betaproteobacteria,1KM2B@119065|unclassified Burkholderiales 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal MMS2_k127_2306834_2 580332.Slit_1590 2.866e-53 189.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2VSDT@28216|Betaproteobacteria,44VZ9@713636|Nitrosomonadales 28216|Betaproteobacteria T cheY-homologous receiver domain cheY2 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg MMS2_k127_2306834_3 1001585.MDS_4529 6.981e-14 80.0 COG1366@1|root,COG1366@2|Bacteria,1N8B6@1224|Proteobacteria,1SDVH@1236|Gammaproteobacteria,1YJN0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T STAS domain - - - - - - - - - - - - STAS_2 MMS2_k127_2306834_0 580332.Slit_1588 5.977e-85 293.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,44W69@713636|Nitrosomonadales 28216|Betaproteobacteria T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt MMS2_k127_2309404_1 1234364.AMSF01000075_gene1936 9.354e-246 764.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt MMS2_k127_2309404_2 666685.R2APBS1_3346 5.111e-90 301.0 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X5UH@135614|Xanthomonadales 135614|Xanthomonadales S mRNA catabolic process - - - - - - - - - - - - - MMS2_k127_2309404_0 666685.R2APBS1_3345 0.0 1025.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1X2XN@135614|Xanthomonadales 135614|Xanthomonadales M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase MMS2_k127_2318321_7 243159.AFE_1861 1.156e-41 161.0 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1SAUS@1236|Gammaproteobacteria,2ND7I@225057|Acidithiobacillales 225057|Acidithiobacillales H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a MMS2_k127_2318321_4 713586.KB900536_gene187 3.203e-80 278.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1WW4C@135613|Chromatiales 135613|Chromatiales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase MMS2_k127_2318321_1 1038869.AXAN01000081_gene2941 1.467e-118 399.0 COG1215@1|root,COG1215@2|Bacteria,1MXXV@1224|Proteobacteria,2VZ3D@28216|Betaproteobacteria,1K61T@119060|Burkholderiaceae 28216|Betaproteobacteria M Chitin synthase - - - ko:K14666 - M00664 - - ko00000,ko00002,ko01000,ko01003 - GT2 - Glycos_transf_2 MMS2_k127_2318321_5 396588.Tgr7_1076 1.208e-52 187.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1WYPB@135613|Chromatiales 135613|Chromatiales FG PFAM Histidine triad (HIT) protein - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT MMS2_k127_2318321_3 519989.ECTPHS_10306 6.48e-84 282.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales 135613|Chromatiales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 MMS2_k127_2318321_6 396588.Tgr7_1074 2.425e-45 166.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1WYVE@135613|Chromatiales 135613|Chromatiales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd MMS2_k127_2318321_0 396588.Tgr7_1073 1.974e-168 545.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales 135613|Chromatiales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 MMS2_k127_2318321_2 1304275.C41B8_00305 5.69e-96 324.0 COG0683@1|root,COG0683@2|Bacteria,1QENW@1224|Proteobacteria,1S1AM@1236|Gammaproteobacteria 1236|Gammaproteobacteria E branched-chain amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS2_k127_2335951_6 391008.Smal_1643 2.066e-10 65.0 2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria,1X7KN@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - MMS2_k127_2335951_2 713586.KB900536_gene303 2.293e-133 444.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1WXIP@135613|Chromatiales 135613|Chromatiales E Belongs to the agmatine deiminase family aguA - - - - - - - - - - - PAD_porph MMS2_k127_2335951_1 396588.Tgr7_1361 5.228e-141 469.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1WW9P@135613|Chromatiales 135613|Chromatiales S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase MMS2_k127_2335951_4 396588.Tgr7_1360 3.522e-68 238.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria,1WX67@135613|Chromatiales 135613|Chromatiales K cyclic nucleotide-binding - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding MMS2_k127_2335951_5 748247.AZKH_0931 6.53e-21 94.0 2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,2KX8R@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 MMS2_k127_2335951_0 472759.Nhal_1366 0.0 1553.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1X0D0@135613|Chromatiales 135613|Chromatiales CEH 'glutamate synthase - - - - - - - - - - - - Pyr_redox_2 MMS2_k127_2335951_3 1120963.KB894498_gene2367 2.668e-132 428.0 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,1RMFD@1236|Gammaproteobacteria,2Q04Q@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2338110_12 1304275.C41B8_01380 1.31e-111 368.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Methylmalonate-semialdehyde dehydrogenase mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_04670 Aldedh MMS2_k127_2338110_11 1122919.KB905601_gene4392 5.59e-113 379.0 COG3718@1|root,COG3718@2|Bacteria,1TR6M@1239|Firmicutes,4HCDY@91061|Bacilli,26UTN@186822|Paenibacillaceae 91061|Bacilli G KduI/IolB family iolB - 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08503 RC00541 ko00000,ko00001,ko01000 - - - KduI MMS2_k127_2338110_0 1178482.BJB45_04900 7.904e-269 841.0 COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,1RQ39@1236|Gammaproteobacteria,1XHSA@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the TPP enzyme family iolD - 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08603 RC02331 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N MMS2_k127_2338110_1 716541.ECL_03802 1.219e-265 832.0 COG0524@1|root,COG3892@1|root,COG0524@2|Bacteria,COG3892@2|Bacteria,1MV6I@1224|Proteobacteria,1RQGH@1236|Gammaproteobacteria,3X2ZS@547|Enterobacter 1236|Gammaproteobacteria G Uncharacterized protein conserved in bacteria (DUF2090) iolC - 2.7.1.92 ko:K03338 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DUF2090,KduI,PfkB MMS2_k127_2338110_7 1225184.ALXE01000029_gene1607 6.695e-126 410.0 COG1082@1|root,COG1082@2|Bacteria,1MW1Z@1224|Proteobacteria,1RZT0@1236|Gammaproteobacteria 1236|Gammaproteobacteria G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N MMS2_k127_2338110_10 634500.EbC_42810 2.729e-118 390.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1RSE0@1236|Gammaproteobacteria,3X7SE@551|Erwinia 1236|Gammaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold iolG - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS2_k127_2338110_5 349163.Acry_2318 9.588e-133 438.0 COG1879@1|root,COG1879@2|Bacteria,1MV17@1224|Proteobacteria,2TUE4@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Periplasmic binding protein LacI transcriptional regulator - - - ko:K02058 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 MMS2_k127_2338110_3 349163.Acry_2317 5.121e-163 521.0 COG1172@1|root,COG1172@2|Bacteria,1MUDF@1224|Proteobacteria,2TS7T@28211|Alphaproteobacteria,2JV6Z@204441|Rhodospirillales 204441|Rhodospirillales G Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 MMS2_k127_2338110_6 349163.Acry_2316 8.644e-131 423.0 COG1129@1|root,COG1129@2|Bacteria,1MW4I@1224|Proteobacteria,2TY4S@28211|Alphaproteobacteria,2JQ71@204441|Rhodospirillales 204441|Rhodospirillales G ATPases associated with a variety of cellular activities - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran MMS2_k127_2338110_16 1304275.C41B8_07837 2.323e-88 300.0 COG1737@1|root,COG1737@2|Bacteria,1MW2B@1224|Proteobacteria,1RNDZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_6,SIS MMS2_k127_2338110_4 1127673.GLIP_1283 8.371e-160 512.0 COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,1RMIK@1236|Gammaproteobacteria,468NA@72275|Alteromonadaceae 1236|Gammaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS2_k127_2338110_9 1208321.D104_13905 3.267e-122 400.0 COG1082@1|root,COG1082@2|Bacteria,1MUQ0@1224|Proteobacteria,1RRXZ@1236|Gammaproteobacteria,1XHB2@135619|Oceanospirillales 135619|Oceanospirillales G Xylose isomerase - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 MMS2_k127_2338110_2 396588.Tgr7_1709 5.188e-239 756.0 COG0835@1|root,COG0835@2|Bacteria,1QVCF@1224|Proteobacteria,1RYBW@1236|Gammaproteobacteria,1X0HK@135613|Chromatiales 135613|Chromatiales NT PFAM CheW domain protein - - - - - - - - - - - - - MMS2_k127_2338110_19 1279015.KB908458_gene2601 1.458e-68 253.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,HAMP,MCPsignal,dCache_1 MMS2_k127_2338110_20 1144319.PMI16_04748 3.468e-38 147.0 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,474U5@75682|Oxalobacteraceae 28216|Betaproteobacteria S MazG-like family - - - - - - - - - - - - MazG-like MMS2_k127_2338110_14 1408419.JHYG01000007_gene2882 6.373e-108 359.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JPVQ@204441|Rhodospirillales 204441|Rhodospirillales E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 MMS2_k127_2338110_13 1397528.Q671_07075 4.516e-109 360.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type spermidine putrescine transport system, permease component I - - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 MMS2_k127_2338110_18 1121943.KB899992_gene2234 3.02e-72 257.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,1XI6A@135619|Oceanospirillales 135619|Oceanospirillales E ABC transporter permease - - - ko:K11070,ko:K11074 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - BPD_transp_1 MMS2_k127_2338110_8 1304275.C41B8_08165 1.306e-122 403.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Required for the activity of the bacterial periplasmic transport system of putrescine - - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_6,SBP_bac_8 MMS2_k127_2338110_15 331869.BAL199_09800 6.644e-96 327.0 COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,2TVMQ@28211|Alphaproteobacteria,4BQ62@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase MMS2_k127_2338110_21 1006004.GBAG_1896 1.764e-08 59.0 COG0604@1|root,COG0604@2|Bacteria,1MXCV@1224|Proteobacteria,1S0AH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 MMS2_k127_2338110_17 1380358.JADJ01000004_gene1945 3.322e-79 273.0 COG0604@1|root,COG0604@2|Bacteria,1MXCV@1224|Proteobacteria,1S0AH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 MMS2_k127_2351809_0 395493.BegalDRAFT_2668 5.921e-151 483.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RNJJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET Belongs to the bacterial solute-binding protein 3 family aapJ - - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 MMS2_k127_2351809_2 1448139.AI20_12910 7.627e-140 455.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,1RN6V@1236|Gammaproteobacteria,1Y3GE@135624|Aeromonadales 135624|Aeromonadales E Binding-protein-dependent transport system inner membrane component - - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 MMS2_k127_2351809_1 399739.Pmen_3558 4.383e-146 471.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,1RPJR@1236|Gammaproteobacteria,1YD04@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component yhdY GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02029,ko:K09971,ko:K10002,ko:K10037 ko02010,ko02020,map02010,map02020 M00227,M00230,M00232,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.2,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 MMS2_k127_2351809_3 384765.SIAM614_13333 1.092e-125 407.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type polar amino acid transport system ATPase component glnQ - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran MMS2_k127_2389960_1 1123368.AUIS01000026_gene1449 1.084e-46 179.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,2NBZC@225057|Acidithiobacillales 225057|Acidithiobacillales JKL Belongs to the DEAD box helicase family - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C MMS2_k127_2389960_0 1249627.D779_1691 6.374e-227 722.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1WWF4@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn MMS2_k127_2389960_2 1123368.AUIS01000006_gene602 3.19e-38 151.0 COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,1S6K2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S CBS domain - - - - - - - - - - - - CBS MMS2_k127_2389960_3 1333856.L686_10260 1.344e-10 63.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,1S74W@1236|Gammaproteobacteria,1Z0DY@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E transporter LysE - - - - - - - - - - - - LysE MMS2_k127_243562_3 1367847.JCM7686_0120 1.686e-07 54.0 COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,2U9KV@28211|Alphaproteobacteria,2PYIR@265|Paracoccus 28211|Alphaproteobacteria S Flavodoxin-like fold - - 1.6.5.2 ko:K00355 ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - Flavodoxin_2 MMS2_k127_243562_2 1380387.JADM01000001_gene131 1.876e-46 173.0 COG0662@1|root,COG0662@2|Bacteria,1RE65@1224|Proteobacteria,1S5FG@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Cupin - - - - - - - - - - - - Cupin_2 MMS2_k127_243562_1 1323663.AROI01000008_gene2610 5.355e-84 293.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1SN8D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red MMS2_k127_243562_0 1123354.AUDR01000002_gene1527 2.427e-105 355.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,1KTBY@119069|Hydrogenophilales 119069|Hydrogenophilales S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 MMS2_k127_2472445_14 1397528.Q671_11375 1.082e-28 116.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,1XHQ1@135619|Oceanospirillales 135619|Oceanospirillales S NAD(P)-dependent - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N MMS2_k127_2472445_15 1205910.B005_1954 1.068e-12 74.0 COG0693@1|root,COG0693@2|Bacteria,2GMFW@201174|Actinobacteria 201174|Actinobacteria Q PFAM ThiJ PfpI domain protein nonF - - - - - - - - - - - DJ-1_PfpI MMS2_k127_2472445_5 1437882.AZRU01000032_gene27 7.253e-86 292.0 COG0693@1|root,COG0693@2|Bacteria,1MVTT@1224|Proteobacteria,1RPVK@1236|Gammaproteobacteria,1YEWI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI MMS2_k127_2472445_10 1158760.AQXP01000020_gene49 3.336e-68 237.0 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,1WYTG@135613|Chromatiales 135613|Chromatiales S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 MMS2_k127_2472445_4 28258.KP05_09255 1.487e-118 394.0 COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,1RZC8@1236|Gammaproteobacteria,1XN43@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyltransferase Family 4 - - - ko:K14335 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 MMS2_k127_2472445_8 1388763.O165_000175 2.31e-75 261.0 COG3233@1|root,COG3233@2|Bacteria,1RIED@1224|Proteobacteria,1S5KC@1236|Gammaproteobacteria,1YYCP@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2334) - - - ko:K06986 - - - - ko00000 - - - DUF2334 MMS2_k127_2472445_6 1123368.AUIS01000005_gene366 9.758e-86 301.0 COG0392@1|root,COG0392@2|Bacteria,1R959@1224|Proteobacteria,1S56U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein - - - - - - - - - - - - LPG_synthase_TM MMS2_k127_2472445_12 981369.JQMJ01000004_gene764 2.588e-53 202.0 COG1309@1|root,COG1309@2|Bacteria,2IFAN@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N MMS2_k127_2472445_9 279714.FuraDRAFT_3506 2.825e-73 251.0 COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria,2KRTA@206351|Neisseriales 206351|Neisseriales Q Isochorismatase family - - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase MMS2_k127_2472445_2 1123393.KB891326_gene76 4.384e-171 550.0 COG1488@1|root,COG1488@2|Bacteria,1PNWY@1224|Proteobacteria,2W9DN@28216|Betaproteobacteria,1KS4Z@119069|Hydrogenophilales 119069|Hydrogenophilales H Nicotinate phosphoribosyltransferase (NAPRTase) family - - - - - - - - - - - - NAPRTase MMS2_k127_2472445_0 243159.AFE_3158 0.0 1088.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,2NCH1@225057|Acidithiobacillales 225057|Acidithiobacillales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HSP90 MMS2_k127_2472445_13 1449357.JQLK01000001_gene700 9.807e-52 200.0 COG2199@1|root,COG3706@2|Bacteria,1WIYY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T TIGRFAM diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - GGDEF MMS2_k127_2472445_11 869210.Marky_0294 2.247e-65 228.0 COG4665@1|root,COG4665@2|Bacteria,1WJCH@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q TRAP-type mannitol chloroaromatic compound transport system small permease component - - - - - - - - - - - - DctQ MMS2_k127_2472445_1 518766.Rmar_2648 4.497e-179 571.0 COG4664@1|root,COG4664@2|Bacteria,4PM5T@976|Bacteroidetes,1FIK6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM MMS2_k127_2472445_3 262724.TT_C1790 1.498e-139 456.0 COG4663@1|root,COG4663@2|Bacteria,1WJ6R@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal MMS2_k127_2476095_3 323261.Noc_2056 4.567e-38 150.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Pfam SNARE associated Golgi protein VV0785 - - - - - - - - - - - SNARE_assoc MMS2_k127_2476095_0 580332.Slit_0395 3.773e-197 637.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,44V6S@713636|Nitrosomonadales 28216|Betaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N MMS2_k127_2476095_2 743722.Sph21_4276 3.061e-131 436.0 COG0362@1|root,COG0362@2|Bacteria,4NG05@976|Bacteroidetes,1IPZC@117747|Sphingobacteriia 976|Bacteroidetes G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 MMS2_k127_2476095_1 637389.Acaty_c2144 1.262e-138 457.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,2NC30@225057|Acidithiobacillales 225057|Acidithiobacillales M Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 MMS2_k127_2491514_2 1049564.TevJSym_af00170 3.248e-142 466.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1J571@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345 SBP_bac_3,SLT MMS2_k127_2491514_1 1500890.JQNL01000001_gene3593 6.909e-196 626.0 2BXCB@1|root,2Z8QU@2|Bacteria,1MZ0I@1224|Proteobacteria,1RRGR@1236|Gammaproteobacteria,1X565@135614|Xanthomonadales 135614|Xanthomonadales M 3HB-oligomer hydrolase (3HBOH) - - 3.1.1.22 ko:K07518 ko00650,map00650 - R00048 RC00037,RC00094 ko00000,ko00001,ko01000 - - - 3HBOH MMS2_k127_2491514_0 1049564.TevJSym_ad01580 0.0 1392.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF MMS2_k127_2491514_4 1207063.P24_10735 1.079e-47 179.0 COG1268@1|root,COG1268@2|Bacteria,1RH78@1224|Proteobacteria,2U9DN@28211|Alphaproteobacteria,2JSZ3@204441|Rhodospirillales 204441|Rhodospirillales S BioY family - - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY MMS2_k127_2491514_3 235985.BBPN01000009_gene3759 1.568e-55 207.0 COG1290@1|root,COG1290@2|Bacteria,2GK58@201174|Actinobacteria,2NI2H@228398|Streptacidiphilus 201174|Actinobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - Cytochrom_B_N_2 MMS2_k127_2491514_5 1449347.JQLN01000007_gene1836 6.975e-45 170.0 COG1290@1|root,COG1290@2|Bacteria,2HG31@201174|Actinobacteria 201174|Actinobacteria C Cytochrome b(N-terminal)/b6/petB - - - - - - - - - - - - Cytochrom_B_N_2 MMS2_k127_2492763_21 1394176.AWUO01000014_gene641 1.44e-07 57.0 2DR0D@1|root,339ND@2|Bacteria,2GXFZ@201174|Actinobacteria,4D1Q4@85004|Bifidobacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS2_k127_2492763_16 713586.KB900536_gene2463 2.817e-40 151.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1WYZ3@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 MMS2_k127_2492763_19 519989.ECTPHS_02094 7.398e-27 109.0 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1WZA6@135613|Chromatiales 135613|Chromatiales J Belongs to the bacterial ribosomal protein bL33 family rpmG - - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 MMS2_k127_2492763_12 395495.Lcho_0023 1.69e-76 269.0 COG5495@1|root,COG5495@2|Bacteria,1RDUW@1224|Proteobacteria,2VRC5@28216|Betaproteobacteria,1KNH6@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Domain of unknown function (DUF2520) - - - - - - - - - - - - DUF2520,F420_oxidored,Rossmann-like MMS2_k127_2492763_2 314278.NB231_13841 2.118e-161 516.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,1RSN1@1236|Gammaproteobacteria,1WVUQ@135613|Chromatiales 135613|Chromatiales I PFAM Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - DDE_Tnp_ISL3,FA_desaturase MMS2_k127_2492763_7 472759.Nhal_0558 7.234e-97 327.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1T1HN@1236|Gammaproteobacteria,1WY5A@135613|Chromatiales 135613|Chromatiales V pfam abc - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_2492763_11 1123400.KB904746_gene1288 1.037e-80 282.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,462CR@72273|Thiotrichales 72273|Thiotrichales S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 MMS2_k127_2492763_6 765914.ThisiDRAFT_1372 5.89e-115 388.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1WX3X@135613|Chromatiales 135613|Chromatiales N PFAM ABC-type uncharacterised transport system - - - - - - - - - - - - ABC_transp_aux MMS2_k127_2492763_18 1283300.ATXB01000001_gene1786 8.978e-29 126.0 2E2KI@1|root,32XPU@2|Bacteria,1RH64@1224|Proteobacteria,1RYC7@1236|Gammaproteobacteria,1XGH6@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 MMS2_k127_2492763_0 686340.Metal_1907 1.224e-197 623.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XDY1@135618|Methylococcales 135618|Methylococcales IQ Belongs to the beta-ketoacyl-ACP synthases family fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt MMS2_k127_2492763_10 1101195.Meth11DRAFT_0932 3.494e-86 289.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2VQ71@28216|Betaproteobacteria,2KM1Q@206350|Nitrosomonadales 206350|Nitrosomonadales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA MMS2_k127_2492763_4 519989.ECTPHS_01604 2.598e-128 438.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo MMS2_k127_2492763_3 338963.Pcar_0024 5.228e-141 469.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2WJ24@28221|Deltaproteobacteria,43UKS@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase MMS2_k127_2492763_1 1255043.TVNIR_2697 2.475e-181 579.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1WWQB@135613|Chromatiales 135613|Chromatiales H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB MMS2_k127_2492763_8 396588.Tgr7_0480 2.367e-93 318.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1WVUX@135613|Chromatiales 135613|Chromatiales M Lipid A biosynthesis lpxL - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans MMS2_k127_2492763_15 1123400.KB904767_gene3433 8.07e-60 218.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M heptosyltransferase rfaQ GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975 Glyco_transf_9 MMS2_k127_2492763_17 1123400.KB904767_gene3433 1.042e-37 144.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M heptosyltransferase rfaQ GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975 Glyco_transf_9 MMS2_k127_2492763_14 279714.FuraDRAFT_0225 4.511e-72 269.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KS1B@206351|Neisseriales 206351|Neisseriales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS2_k127_2492763_9 1121004.ATVC01000001_gene368 4.276e-87 313.0 COG0726@1|root,COG0726@2|Bacteria,1MZFC@1224|Proteobacteria,2VK3N@28216|Betaproteobacteria,2KTS1@206351|Neisseriales 206351|Neisseriales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 MMS2_k127_2492763_13 279714.FuraDRAFT_0227 1.883e-73 262.0 COG0859@1|root,COG0859@2|Bacteria,1PEYZ@1224|Proteobacteria,2VXSS@28216|Betaproteobacteria 28216|Betaproteobacteria H Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 MMS2_k127_2492763_5 279714.FuraDRAFT_0228 7.369e-118 390.0 COG0438@1|root,COG0438@2|Bacteria,1PEZ0@1224|Proteobacteria,2W92V@28216|Betaproteobacteria,2KT86@206351|Neisseriales 206351|Neisseriales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS2_k127_2492763_20 1536769.P40081_34440 1.353e-13 78.0 COG1216@1|root,COG1216@2|Bacteria,1UYRR@1239|Firmicutes,4HEJ1@91061|Bacilli,26TD7@186822|Paenibacillaceae 91061|Bacilli S glycosyl transferase family 2 galnac-T15 - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glyco_transf_7C,Glycos_transf_2 MMS2_k127_2519090_1 1158292.JPOE01000002_gene3740 2.89e-177 560.0 COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2VICA@28216|Betaproteobacteria,1KPA2@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Phage integrase SAM-like domain - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase MMS2_k127_2519090_0 1158292.JPOE01000002_gene3741 1.333e-181 573.0 COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2VMDS@28216|Betaproteobacteria,1KKD9@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase MMS2_k127_2519090_2 1158292.JPOE01000002_gene3742 2.547e-157 501.0 COG4973@1|root,COG4973@2|Bacteria 2|Bacteria D DNA integration - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase MMS2_k127_2519090_3 1112204.GPOL_c47100 8.801e-10 60.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4GAYZ@85026|Gordoniaceae 201174|Actinobacteria IQ AMP-binding enzyme - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C MMS2_k127_2542201_4 932677.PAJ_0084 5.732e-07 51.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,3W099@53335|Pantoea 1236|Gammaproteobacteria H Belongs to the NadC ModD family nadC GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0109 QRPTase_C,QRPTase_N MMS2_k127_2542201_0 396588.Tgr7_2503 1.725e-58 212.0 COG1018@1|root,COG1018@2|Bacteria,1R5FN@1224|Proteobacteria 1224|Proteobacteria C Oxidoreductase FAD-binding domain protein - - - - - - - - - - - - FAD_binding_6,NAD_binding_1 MMS2_k127_2542201_2 519989.ECTPHS_09909 6.702e-47 179.0 2E609@1|root,330PP@2|Bacteria,1NA0P@1224|Proteobacteria,1SCFG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S YfaZ precursor - - - - - - - - - - - - YfaZ MMS2_k127_2542201_1 1123368.AUIS01000010_gene2378 1.338e-47 173.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator yeeY - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2542738_0 713586.KB900536_gene1841 2.179e-318 981.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase MMS2_k127_2542738_1 519989.ECTPHS_11812 5.612e-186 613.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 MMS2_k127_2542738_2 713586.KB900536_gene1843 9.106e-78 262.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 MMS2_k127_2554798_0 314345.SPV1_12617 7.191e-235 736.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria 1224|Proteobacteria HJ Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) rimK - - - - - - - - - - - Dala_Dala_lig_C,RLAN,RimK MMS2_k127_2554798_1 314345.SPV1_12622 8.278e-40 150.0 COG2866@1|root,COG2866@2|Bacteria,1N6CX@1224|Proteobacteria 1224|Proteobacteria E Protein of unknown function (DUF2817) - - - - - - - - - - - - DUF2817 MMS2_k127_2560543_1 765911.Thivi_1570 3.299e-282 867.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales 135613|Chromatiales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N MMS2_k127_2560543_10 572477.Alvin_1366 1.578e-65 227.0 COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,1S3XZ@1236|Gammaproteobacteria,1X23Q@135613|Chromatiales 135613|Chromatiales C PFAM Ribulose bisphosphate carboxylase, small chain - - 4.1.1.39 ko:K01602 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_small MMS2_k127_2560543_4 349124.Hhal_1044 1.089e-151 481.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WWX8@135613|Chromatiales 135613|Chromatiales S ATPase associated with various cellular activities, AAA_5 - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C MMS2_k127_2560543_9 765912.Thimo_3272 3.684e-83 282.0 COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,1WW4H@135613|Chromatiales 135613|Chromatiales J PFAM methyltransferase small - - - - - - - - - - - - MTS,MTS_N MMS2_k127_2560543_0 243233.MCA2754 0.0 1064.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM von Willebrand factor type A - - - - - - - - - - - - VWA MMS2_k127_2560543_11 398767.Glov_0555 3.592e-63 223.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,43ADI@68525|delta/epsilon subdivisions,2WPU6@28221|Deltaproteobacteria,43SN5@69541|Desulfuromonadales 28221|Deltaproteobacteria H Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA MMS2_k127_2560543_13 713586.KB900536_gene914 3.706e-31 130.0 2AE70@1|root,3140Y@2|Bacteria,1RK0Q@1224|Proteobacteria,1S6JU@1236|Gammaproteobacteria,1WYRY@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_2560543_15 375286.mma_1786 1.876e-18 95.0 COG3637@1|root,COG3637@2|Bacteria,1NG4D@1224|Proteobacteria,2W4Y9@28216|Betaproteobacteria,4770Q@75682|Oxalobacteraceae 28216|Betaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - MMS2_k127_2560543_14 675814.VIC_000638 1.43e-25 110.0 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1XXSJ@135623|Vibrionales 135623|Vibrionales C COG2863 Cytochrome c553 - - - - - - - - - - - - Cytochrom_C MMS2_k127_2560543_12 396595.TK90_0527 5.141e-51 186.0 COG5615@1|root,COG5615@2|Bacteria,1RH6D@1224|Proteobacteria,1S6S2@1236|Gammaproteobacteria,1WZE3@135613|Chromatiales 135613|Chromatiales S Copper resistance protein D - - - - - - - - - - - - CopD MMS2_k127_2560543_5 396588.Tgr7_2879 5.271e-130 417.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1WX9I@135613|Chromatiales 135613|Chromatiales G Belongs to the ribulose-phosphate 3-epimerase family - - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim MMS2_k127_2560543_8 713587.THITH_15880 3.218e-89 299.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales 135613|Chromatiales G HAD-superfamily hydrolase, subfamily IA, variant 3 gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 MMS2_k127_2560543_7 290398.Csal_2729 2.307e-114 379.0 COG0583@1|root,COG0583@2|Bacteria,1N4P5@1224|Proteobacteria,1RSQH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K11921 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate MMS2_k127_2560543_2 290398.Csal_2937 1.608e-178 576.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1XI5B@135619|Oceanospirillales 135619|Oceanospirillales V MATE efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE MMS2_k127_2560543_3 103690.17135341 8.023e-163 526.0 COG3408@1|root,COG3408@2|Bacteria,1G2UV@1117|Cyanobacteria,1HRKT@1161|Nostocales 1117|Cyanobacteria G Alkaline and neutral invertase invA - 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 - GH32 - Glyco_hydro_100 MMS2_k127_2560543_6 1205753.A989_19513 1.537e-121 401.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X47D@135614|Xanthomonadales 135614|Xanthomonadales E Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 MMS2_k127_2560543_16 1123401.JHYQ01000014_gene822 2.832e-06 49.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,461ME@72273|Thiotrichales 72273|Thiotrichales V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran MMS2_k127_2578425_0 519989.ECTPHS_02646 1.946e-251 782.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1WXB2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - Aminotran_5,GDC-P MMS2_k127_2578425_3 1158146.KB907131_gene1323 2.38e-43 161.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1WYCK@135613|Chromatiales 135613|Chromatiales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar MMS2_k127_2578425_1 1411123.JQNH01000001_gene1608 1.613e-170 543.0 COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria E cystathionine metC - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP MMS2_k127_2578425_2 1207063.P24_06916 6.379e-65 229.0 COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2U580@28211|Alphaproteobacteria,2JZJC@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_24 MMS2_k127_2578425_4 1266925.JHVX01000006_gene2211 5.575e-31 131.0 COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA MMS2_k127_2581542_0 105559.Nwat_2191 2.74e-213 686.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 MMS2_k127_2581542_13 768671.ThimaDRAFT_1560 2.195e-40 157.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales 135613|Chromatiales S Sterol-binding domain protein - - - ko:K03690 - - - - ko00000 - - - SCP2 MMS2_k127_2581542_14 1415778.JQMM01000001_gene35 2.17e-38 150.0 COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,1S6E9@1236|Gammaproteobacteria,1J6IT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein domain - - - - - - - - - - - - DUF4339,RDD MMS2_k127_2581542_4 1123401.JHYQ01000010_gene2460 1.591e-122 398.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,45ZTM@72273|Thiotrichales 72273|Thiotrichales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran MMS2_k127_2581542_12 545276.KB898729_gene1658 5.089e-55 200.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1WYD9@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 MMS2_k127_2581542_10 1205680.CAKO01000014_gene96 3.299e-65 228.0 COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,2U7T5@28211|Alphaproteobacteria,2JSZ5@204441|Rhodospirillales 204441|Rhodospirillales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 MMS2_k127_2581542_1 396588.Tgr7_0057 7.972e-212 666.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales 135613|Chromatiales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small MMS2_k127_2581542_8 1255043.TVNIR_0084 2.132e-88 294.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome MMS2_k127_2581542_7 396588.Tgr7_0047 1.691e-93 325.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase MMS2_k127_2581542_9 396588.Tgr7_0046 1.089e-72 251.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales 135613|Chromatiales S Protein of unknown function, DUF484 - - - ko:K09921 - - - - ko00000 - - - DUF484 MMS2_k127_2581542_6 247634.GPB2148_273 7.56e-107 353.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1J4UU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase MMS2_k127_2581542_16 292415.Tbd_0574 1.082e-31 128.0 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,1KTCC@119069|Hydrogenophilales 119069|Hydrogenophilales O Sulfurtransferase TusA - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA MMS2_k127_2581542_2 713586.KB900536_gene2176 3.065e-199 627.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales 135613|Chromatiales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC MMS2_k127_2581542_5 1068980.ARVW01000001_gene7362 3.605e-111 364.0 COG2267@1|root,COG2267@2|Bacteria,2IFK6@201174|Actinobacteria,4E4SH@85010|Pseudonocardiales 201174|Actinobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 MMS2_k127_2581542_11 1123377.AUIV01000006_gene1543 3.17e-56 205.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1X4YF@135614|Xanthomonadales 135614|Xanthomonadales S Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 MMS2_k127_2581542_15 396588.Tgr7_1428 5.066e-33 131.0 2EC4Z@1|root,3363S@2|Bacteria,1N9YG@1224|Proteobacteria,1SSSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2581542_17 323261.Noc_0305 7.21e-21 106.0 COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,1SFVY@1236|Gammaproteobacteria,1X1TN@135613|Chromatiales 135613|Chromatiales H Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 MMS2_k127_2581542_3 1163408.UU9_13182 3.56e-187 596.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1X3NI@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N MMS2_k127_2593812_5 396588.Tgr7_0113 1.116e-83 287.0 COG0524@1|root,COG0524@2|Bacteria,1MWX4@1224|Proteobacteria,1RQW6@1236|Gammaproteobacteria,1WWFX@135613|Chromatiales 135613|Chromatiales G PFAM PfkB domain protein - - 2.7.1.3 ko:K00846 ko00051,ko01100,ko01120,map00051,map01100,map01120 - R00866,R03819 RC00002,RC00017,RC00608 ko00000,ko00001,ko01000,ko04147 - - - PfkB MMS2_k127_2593812_8 1158182.KB905020_gene2282 8.374e-05 51.0 298KX@1|root,2ZVRP@2|Bacteria,1P89W@1224|Proteobacteria,1SUU7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2593812_2 314345.SPV1_12415 9.907e-122 404.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria 1224|Proteobacteria M mechanosensitive ion channel aefA - - - - - - - - - - - MS_channel MMS2_k127_2593812_1 765912.Thimo_3101 8.952e-155 501.0 COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,1T2RW@1236|Gammaproteobacteria,1X2P1@135613|Chromatiales 135613|Chromatiales P PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 MMS2_k127_2593812_7 287.DR97_215 1.54e-40 154.0 COG2703@1|root,COG2703@2|Bacteria,1RI40@1224|Proteobacteria,1S60H@1236|Gammaproteobacteria,1YGAC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms - - - ko:K07216 - - - - ko00000 - - - Hemerythrin MMS2_k127_2593812_6 1226994.AMZB01000083_gene301 8.126e-50 182.0 COG2703@1|root,COG2703@2|Bacteria,1RI40@1224|Proteobacteria,1S60H@1236|Gammaproteobacteria,1YGAC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms - - - ko:K07216 - - - - ko00000 - - - Hemerythrin MMS2_k127_2593812_4 1156919.QWC_23440 6.604e-87 291.0 COG1280@1|root,COG1280@2|Bacteria,1R5TV@1224|Proteobacteria,2VQ68@28216|Betaproteobacteria,3T5P1@506|Alcaligenaceae 28216|Betaproteobacteria E threonine efflux protein - - - - - - - - - - - - LysE MMS2_k127_2593812_3 1123401.JHYQ01000029_gene1956 4.439e-113 375.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales 72273|Thiotrichales L Exodeoxyribonuclease III xth xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos MMS2_k127_2593812_0 587753.EY04_04850 2.211e-199 640.0 COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N MMS2_k127_2608877_3 1234364.AMSF01000055_gene1048 1.173e-27 113.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1RZ95@1236|Gammaproteobacteria,1X3T7@135614|Xanthomonadales 135614|Xanthomonadales P transport protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA MMS2_k127_2608877_0 666685.R2APBS1_2955 2.398e-194 614.0 28I3N@1|root,2Z87C@2|Bacteria,1R8BJ@1224|Proteobacteria,1S1F3@1236|Gammaproteobacteria,1X2XC@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 MMS2_k127_2608877_1 1234364.AMSF01000055_gene1046 1.403e-171 540.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1X3M9@135614|Xanthomonadales 135614|Xanthomonadales P Transporter corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC MMS2_k127_2608877_2 1163407.UU7_10102 2.086e-76 261.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1X6SP@135614|Xanthomonadales 135614|Xanthomonadales J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 MMS2_k127_2608877_4 1392838.AWNM01000079_gene2799 2.799e-14 73.0 COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,2VTCX@28216|Betaproteobacteria 28216|Betaproteobacteria S esterase of the alpha beta hydrolase fold - - - ko:K07002 - - - - ko00000 - - - Ser_hydrolase MMS2_k127_2633186_0 414684.RC1_3121 2.208e-93 309.0 COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,2TRS7@28211|Alphaproteobacteria,2JQ2M@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase MMS2_k127_2633186_1 105559.Nwat_2878 4.912e-63 226.0 COG1278@1|root,COG3326@1|root,COG1278@2|Bacteria,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,1SCMX@1236|Gammaproteobacteria,1WZHU@135613|Chromatiales 135613|Chromatiales K Cold-shock protein, DNA-binding - - - - - - - - - - - - CSD,DUF1294 MMS2_k127_2633186_2 311402.Avi_3260 9.689e-40 154.0 COG0454@1|root,COG0456@2|Bacteria,1R4SN@1224|Proteobacteria,2U0VQ@28211|Alphaproteobacteria,4BBQR@82115|Rhizobiaceae 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2633186_3 42565.FP66_00715 1.413e-30 121.0 COG0679@1|root,COG0679@2|Bacteria,1PINE@1224|Proteobacteria,1S1F1@1236|Gammaproteobacteria,1XS4C@135619|Oceanospirillales 135619|Oceanospirillales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans MMS2_k127_2643245_11 404589.Anae109_1572 6.677e-39 155.0 COG3842@1|root,COG3842@2|Bacteria,1RC3N@1224|Proteobacteria,43AKP@68525|delta/epsilon subdivisions,2X60N@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ABC transporter - - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE MMS2_k127_2643245_1 1118153.MOY_08593 2.879e-163 532.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1XHYU@135619|Oceanospirillales 135619|Oceanospirillales G Alpha amylase, catalytic domain - - 2.4.1.7 ko:K00690 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C MMS2_k127_2643245_10 42565.FP66_05570 1.232e-39 149.0 COG2329@1|root,COG2329@2|Bacteria,1N062@1224|Proteobacteria,1SABZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S enzyme involved in biosynthesis of extracellular polysaccharides yqjZ - - - - - - - - - - - ABM MMS2_k127_2643245_2 519989.ECTPHS_05851 5.216e-157 515.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales 135613|Chromatiales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 MMS2_k127_2643245_4 713586.KB900536_gene502 2.911e-87 295.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1WXA6@135613|Chromatiales 135613|Chromatiales H riboflavin synthase, alpha subunit - - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding MMS2_k127_2643245_3 713586.KB900536_gene501 3.708e-146 473.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 MMS2_k127_2643245_6 396588.Tgr7_1558 1.638e-73 250.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1WX91@135613|Chromatiales 135613|Chromatiales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone MMS2_k127_2643245_0 1249627.D779_1804 1.906e-225 704.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT MMS2_k127_2643245_5 396588.Tgr7_1187 3.773e-75 258.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1WY23@135613|Chromatiales 135613|Chromatiales I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB MMS2_k127_2643245_9 118168.MC7420_188 1.156e-49 183.0 COG0645@1|root,COG0645@2|Bacteria,1G714@1117|Cyanobacteria,1HBNN@1150|Oscillatoriales 1117|Cyanobacteria S Cell division protein ZipA - - - - - - - - - - - - AAA_33 MMS2_k127_2643245_12 1117318.PRUB_13081 1.087e-30 124.0 COG5470@1|root,COG5470@2|Bacteria,1PJI3@1224|Proteobacteria,1SY57@1236|Gammaproteobacteria,2Q54J@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 MMS2_k127_2643245_8 296591.Bpro_0144 4.092e-64 221.0 COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,4AEJT@80864|Comamonadaceae 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase MMS2_k127_2643245_13 1034943.BN1094_01655 9.52e-22 102.0 2ERG8@1|root,33J1S@2|Bacteria,1NMXE@1224|Proteobacteria,1SVEJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 MMS2_k127_2643245_7 1232683.ADIMK_0083 2.155e-66 231.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1T40A@1236|Gammaproteobacteria,46AZ2@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS MMS2_k127_2663184_1 1163409.UUA_04978 8.095e-104 342.0 COG0475@1|root,COG0475@2|Bacteria,1QTSD@1224|Proteobacteria,1T1FK@1236|Gammaproteobacteria,1XDAV@135614|Xanthomonadales 135614|Xanthomonadales P Kef-type K transport - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger MMS2_k127_2663184_2 1234364.AMSF01000016_gene1614 2.825e-76 265.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,1X4MM@135614|Xanthomonadales 135614|Xanthomonadales O peptidylprolyl - - 5.2.1.8 ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N MMS2_k127_2663184_0 1500890.JQNL01000001_gene3857 4.952e-231 721.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1X4NT@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N MMS2_k127_2663184_3 1500893.JQNB01000001_gene2341 4.479e-14 74.0 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1T6V1@1236|Gammaproteobacteria,1X87K@135614|Xanthomonadales 135614|Xanthomonadales S SlyX - - - ko:K03745 - - - - ko00000 - - - SlyX MMS2_k127_2663184_4 1123253.AUBD01000001_gene1697 1.291e-09 64.0 COG3122@1|root,COG3122@2|Bacteria,1P4D6@1224|Proteobacteria,1SGUC@1236|Gammaproteobacteria,1X2Y4@135614|Xanthomonadales 135614|Xanthomonadales S Nucleoprotein polynucleotide-associated enzyme - - - ko:K09912 - - - - ko00000 - - - DUF2058 MMS2_k127_267017_0 870187.Thini_0259 4.427e-88 294.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,460EX@72273|Thiotrichales 72273|Thiotrichales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW MMS2_k127_267017_3 870187.Thini_0260 2.73e-44 164.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,461E7@72273|Thiotrichales 72273|Thiotrichales S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA MMS2_k127_267017_2 697282.Mettu_4130 1.333e-51 198.0 COG3259@1|root,COG3259@2|Bacteria,1RFVW@1224|Proteobacteria,1T354@1236|Gammaproteobacteria,1XG2J@135618|Methylococcales 135618|Methylococcales C Nickel-dependent hydrogenase - - - - - - - - - - - - - MMS2_k127_267017_4 697282.Mettu_4131 8.954e-31 128.0 COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,1SCZ7@1236|Gammaproteobacteria,1XGF1@135618|Methylococcales 135618|Methylococcales C Pfam:DUF3457 - - - - - - - - - - - - NiFe-hyd_HybE MMS2_k127_267017_5 1122201.AUAZ01000001_gene2316 4.506e-27 121.0 COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria,1SC8U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Rubredoxin - - - - - - - - - - - - Rubredoxin MMS2_k127_267017_1 1446473.JHWH01000001_gene1084 1.074e-60 215.0 COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2TV0P@28211|Alphaproteobacteria,2PWNK@265|Paracoccus 28211|Alphaproteobacteria C HupH hydrogenase expression protein, C-terminal conserved region hupH - - ko:K03618 - - - - ko00000 - - - HupH_C MMS2_k127_2746571_5 713586.KB900536_gene2968 2.508e-79 270.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,1WXAH@135613|Chromatiales 135613|Chromatiales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind MMS2_k127_2746571_11 396588.Tgr7_0923 1.704e-51 186.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 MMS2_k127_2746571_15 1469245.JFBG01000011_gene842 2.323e-35 135.0 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,1WYXU@135613|Chromatiales 135613|Chromatiales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 MMS2_k127_2746571_12 713586.KB900536_gene2975 1.965e-50 190.0 2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1WXMV@135613|Chromatiales 135613|Chromatiales S membrane - - - - - - - - - - - - DUF2232 MMS2_k127_2746571_8 1255043.TVNIR_3257 8.904e-59 207.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1WYD2@135613|Chromatiales 135613|Chromatiales J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N MMS2_k127_2746571_1 396588.Tgr7_0927 1.247e-220 692.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 MMS2_k127_2746571_4 713586.KB900536_gene2978 2.3e-110 368.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1WWIB@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N MMS2_k127_2746571_3 396588.Tgr7_2203 6.145e-123 408.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1S7EZ@1236|Gammaproteobacteria,1X01B@135613|Chromatiales 135613|Chromatiales I Membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X MMS2_k127_2746571_6 713586.KB900536_gene1027 1.107e-76 267.0 COG3439@1|root,COG3439@2|Bacteria,1MXYT@1224|Proteobacteria,1SAK5@1236|Gammaproteobacteria,1X0WH@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - - MMS2_k127_2746571_10 396588.Tgr7_2169 3.528e-55 198.0 2F8JF@1|root,340Y7@2|Bacteria,1NYW2@1224|Proteobacteria,1SQHY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2746571_7 396588.Tgr7_2168 3.038e-73 259.0 COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria,1SQ47@1236|Gammaproteobacteria 1236|Gammaproteobacteria H PFAM biotin lipoate A B protein ligase - - - - - - - - - - - - BPL_LplA_LipB MMS2_k127_2746571_9 396588.Tgr7_2167 4.984e-57 200.0 2F7T9@1|root,3407E@2|Bacteria,1NYX3@1224|Proteobacteria,1SQI5@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2746571_13 748658.KB907312_gene1267 6.37e-44 162.0 2FIAJ@1|root,34A2Z@2|Bacteria,1P28Q@1224|Proteobacteria,1SSYY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2746571_14 396588.Tgr7_2165 2.472e-42 159.0 2CJFI@1|root,32XF5@2|Bacteria,1N623@1224|Proteobacteria,1SRCG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_2746571_2 396588.Tgr7_2164 4.786e-141 452.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WWX8@135613|Chromatiales 1236|Gammaproteobacteria S ATPase associated with various cellular activities, AAA_5 - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C MMS2_k127_2746571_0 396588.Tgr7_2163 0.0 1113.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria,1X258@135613|Chromatiales 135613|Chromatiales P von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - MMS2_k127_2746571_16 1266908.AQPB01000041_gene1586 1.295e-29 124.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales 135613|Chromatiales BQ PFAM histone deacetylase superfamily - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl MMS2_k127_2747564_3 1158292.JPOE01000002_gene2810 3.942e-288 889.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,1KIZQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C MMS2_k127_2747564_15 358220.C380_15305 1.63e-90 314.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,2WHJC@28216|Betaproteobacteria,4AJYD@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF MMS2_k127_2747564_20 1278309.KB907109_gene3244 1.082e-55 199.0 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,1XKMI@135619|Oceanospirillales 135619|Oceanospirillales CO Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA,Redoxin MMS2_k127_2747564_0 314278.NB231_10293 0.0 2083.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales 135613|Chromatiales E PFAM NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH MMS2_k127_2747564_30 1232683.ADIMK_2907 2.38e-09 63.0 2CEPM@1|root,33NPI@2|Bacteria,1NJ0A@1224|Proteobacteria,1SHN3@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF1127 MMS2_k127_2747564_9 1121939.L861_10740 1.801e-148 474.0 COG0583@1|root,COG0583@2|Bacteria,1PR6U@1224|Proteobacteria,1RQ7J@1236|Gammaproteobacteria,1XKT4@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2747564_24 1322246.BN4_11070 3.532e-46 177.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2M96Q@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 MMS2_k127_2747564_13 1144319.PMI16_03260 1.827e-102 341.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2VI5H@28216|Betaproteobacteria,474JN@75682|Oxalobacteraceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_2747564_5 365044.Pnap_3019 4.362e-208 657.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2VIP0@28216|Betaproteobacteria,4AAXE@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 MMS2_k127_2747564_11 358220.C380_18725 1.583e-138 444.0 COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,4ACUT@80864|Comamonadaceae 28216|Betaproteobacteria E Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety kynA GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase MMS2_k127_2747564_19 1419583.V466_12030 2.183e-56 202.0 COG0454@1|root,COG0454@2|Bacteria,1RD5R@1224|Proteobacteria,1S4R5@1236|Gammaproteobacteria,1YSBG@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K GNAT family - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2747564_26 1415754.JQMK01000002_gene2208 1.191e-37 151.0 COG2105@1|root,COG2105@2|Bacteria,1RHE8@1224|Proteobacteria,1S708@1236|Gammaproteobacteria,46BA8@72275|Alteromonadaceae 1236|Gammaproteobacteria S AIG2-like family - - - - - - - - - - - - AIG2_2,GGACT MMS2_k127_2747564_7 396588.Tgr7_0573 1.429e-153 495.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,1RNDG@1236|Gammaproteobacteria,1WX3F@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase M20A family. ArgE subfamily - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 MMS2_k127_2747564_17 396588.Tgr7_2909 9.626e-75 261.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1X2IQ@135613|Chromatiales 135613|Chromatiales M TIGRFAM TonB family protein - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C MMS2_k127_2747564_18 765914.ThisiDRAFT_2061 2.085e-59 208.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria,1WXZR@135613|Chromatiales 135613|Chromatiales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese MMS2_k127_2747564_12 1380387.JADM01000004_gene2958 3.472e-132 428.0 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,1RMTI@1236|Gammaproteobacteria,1XI2Z@135619|Oceanospirillales 135619|Oceanospirillales O Glutathione S-transferase - - 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 MMS2_k127_2747564_28 1395571.TMS3_0112650 4.692e-33 134.0 COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane yqjF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K15977 - - - - ko00000 - - - DoxX MMS2_k127_2747564_22 1121090.KB894694_gene2159 9.319e-48 177.0 COG1917@1|root,COG1917@2|Bacteria,1V719@1239|Firmicutes,4HIPQ@91061|Bacilli,1ZGMT@1386|Bacillus 91061|Bacilli S Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant ectC - 4.2.1.108 ko:K06720 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06979 RC01729 ko00000,ko00001,ko00002,ko01000 - - - Ectoine_synth MMS2_k127_2747564_6 1033743.CAES01000011_gene4273 8.422e-165 538.0 COG0160@1|root,COG0160@2|Bacteria,1TRUG@1239|Firmicutes,4HBUU@91061|Bacilli,26QMY@186822|Paenibacillaceae 91061|Bacilli E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family ectB - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 MMS2_k127_2747564_25 472759.Nhal_2708 4.021e-46 175.0 COG0454@1|root,COG0456@2|Bacteria,1RHB7@1224|Proteobacteria,1S3TD@1236|Gammaproteobacteria,1WZ5V@135613|Chromatiales 135613|Chromatiales K L-2,4-diaminobutyric acid acetyltransferase - - 2.3.1.178 ko:K06718 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06978 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 MMS2_k127_2747564_23 1249627.D779_3015 5.182e-47 177.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria,1WZMS@135613|Chromatiales 135613|Chromatiales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 MMS2_k127_2747564_16 870187.Thini_2280 2.655e-78 266.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,1T2WV@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_11,Fer4_4 MMS2_k127_2747564_2 187272.Mlg_1297 0.0 1043.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde ferredoxin oxidoreductase ydhV GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N MMS2_k127_2747564_8 870187.Thini_2282 1.006e-150 490.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,461X5@72273|Thiotrichales 72273|Thiotrichales S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 MMS2_k127_2747564_29 1100720.ALKN01000044_gene1998 1.066e-13 81.0 COG2104@1|root,COG2104@2|Bacteria,1N9VX@1224|Proteobacteria,2VVYE@28216|Betaproteobacteria,4AFRB@80864|Comamonadaceae 28216|Betaproteobacteria H PFAM thiamineS protein - - - - - - - - - - - - ThiS,Ub-Mut7C MMS2_k127_2747564_21 1121448.DGI_3496 1.401e-53 219.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,42PJK@68525|delta/epsilon subdivisions,2WMCS@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core MMS2_k127_2747564_10 1249627.D779_0958 1.507e-143 485.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1WWR8@135613|Chromatiales 135613|Chromatiales S PFAM Bacterial domain of - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 MMS2_k127_2747564_1 870187.Thini_1347 0.0 1632.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,461RZ@72273|Thiotrichales 72273|Thiotrichales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core MMS2_k127_2747564_4 395493.BegalDRAFT_2644 1.3e-235 740.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,46043@72273|Thiotrichales 72273|Thiotrichales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 MMS2_k127_2747564_14 768671.ThimaDRAFT_1217 2.536e-100 337.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1WXDA@135613|Chromatiales 135613|Chromatiales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E MMS2_k127_2766282_6 1101192.KB910516_gene3739 1.411e-11 69.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,1JV4E@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX MMS2_k127_2766282_0 666685.R2APBS1_2355 6.351e-168 537.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,1RPAT@1236|Gammaproteobacteria,1X5NI@135614|Xanthomonadales 135614|Xanthomonadales EGP Major facilitator superfamily ynfM - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1,Sugar_tr MMS2_k127_2766282_5 153948.NAL212_2253 5.44e-43 162.0 COG3795@1|root,COG3795@2|Bacteria,1N32U@1224|Proteobacteria,2VWKN@28216|Betaproteobacteria 28216|Betaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII MMS2_k127_2766282_2 1097668.BYI23_A015020 1.661e-68 237.0 COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VS3X@28216|Betaproteobacteria,1KH9H@119060|Burkholderiaceae 28216|Betaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase MMS2_k127_2766282_4 342113.DM82_6119 4.924e-58 205.0 COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2VSH3@28216|Betaproteobacteria,1K72M@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM DGPFAETKE family protein - - - - - - - - - - - - YCII MMS2_k127_2766282_1 748280.NH8B_0901 6.408e-75 255.0 COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,2KT22@206351|Neisseriales 206351|Neisseriales S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt MMS2_k127_2766282_3 479434.Sthe_2955 1.662e-67 233.0 COG4941@1|root,COG4941@2|Bacteria,2G84R@200795|Chloroflexi 200795|Chloroflexi K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 MMS2_k127_2784087_41 1265313.HRUBRA_01520 4.732e-47 170.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1J5IF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - ko:K01663,ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iYL1228.KPN_02481 His_biosynth MMS2_k127_2784087_37 497321.C664_04737 1.11e-57 204.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,2KWD3@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH MMS2_k127_2784087_43 765910.MARPU_00345 8.833e-44 163.0 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1WYHH@135613|Chromatiales 135613|Chromatiales E phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH MMS2_k127_2784087_50 1122604.JONR01000010_gene3840 4.938e-12 72.0 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1X840@135614|Xanthomonadales 135614|Xanthomonadales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 MMS2_k127_2784087_48 1158756.AQXQ01000011_gene532 1.474e-24 109.0 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1WZ88@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 MMS2_k127_2784087_29 765914.ThisiDRAFT_0559 4.247e-91 308.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC MMS2_k127_2784087_3 396588.Tgr7_0222 8.572e-233 731.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1WVY6@135613|Chromatiales 135613|Chromatiales G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N MMS2_k127_2784087_44 637390.AFOH01000001_gene908 6.131e-42 162.0 COG3038@1|root,COG3038@2|Bacteria 2|Bacteria C cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB MMS2_k127_2784087_13 349163.Acry_0648 2.602e-161 523.0 COG0531@1|root,COG0531@2|Bacteria,1NQTH@1224|Proteobacteria,2TUFW@28211|Alphaproteobacteria,2JRZT@204441|Rhodospirillales 204441|Rhodospirillales E Amino acid permease - - - - - - - - - - - - AA_permease,AA_permease_2 MMS2_k127_2784087_11 472759.Nhal_0232 3.271e-166 535.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1WWMQ@135613|Chromatiales 135613|Chromatiales C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS2_k127_2784087_26 305900.GV64_09590 2.274e-104 361.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,1XI6A@135619|Oceanospirillales 135619|Oceanospirillales E ABC transporter permease - - - ko:K11070,ko:K11074 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - - BPD_transp_1 MMS2_k127_2784087_22 1384056.N787_01035 4.289e-119 406.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,1X4Y3@135614|Xanthomonadales 135614|Xanthomonadales E ABC-type spermidine putrescine transport system, permease component I potH - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 MMS2_k127_2784087_17 395493.BegalDRAFT_0292 1.13e-145 473.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RNPX@1236|Gammaproteobacteria,45ZWX@72273|Thiotrichales 72273|Thiotrichales P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - - ko:K11076 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - ABC_tran,TOBE_2 MMS2_k127_2784087_18 745411.B3C1_03265 1.281e-135 441.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1J4HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Required for the activity of the bacterial periplasmic transport system of putrescine potF1 - - ko:K11073 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - SBP_bac_8 MMS2_k127_2784087_7 1437882.AZRU01000001_gene2114 3.124e-205 655.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1YET7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family spuC - 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 - R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 MMS2_k127_2784087_5 395493.BegalDRAFT_2999 1.121e-212 668.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,461WQ@72273|Thiotrichales 72273|Thiotrichales E Glutamine synthetase, catalytic domain - - - - - - - - - - - - Gln-synt_C MMS2_k127_2784087_28 269482.Bcep1808_3079 1.768e-94 315.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VQ7R@28216|Betaproteobacteria,1KGX0@119060|Burkholderiaceae 28216|Betaproteobacteria S Pfam Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 MMS2_k127_2784087_15 42565.FP66_10105 1.901e-154 500.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XHZD@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamine synthetase family - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C MMS2_k127_2784087_14 1121004.ATVC01000019_gene1846 5.29e-155 502.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2VIFN@28216|Betaproteobacteria,2KPQZ@206351|Neisseriales 206351|Neisseriales E FAD dependent oxidoreductase ordL - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO MMS2_k127_2784087_42 1434929.X946_1903 3.209e-44 166.0 COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,2VV7K@28216|Betaproteobacteria,1KHF4@119060|Burkholderiaceae 28216|Betaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase MMS2_k127_2784087_33 1163617.SCD_n00294 2.143e-65 226.0 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2VRA3@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase MMS2_k127_2784087_35 794903.OPIT5_13235 3.924e-64 225.0 COG0645@1|root,COG0645@2|Bacteria 2|Bacteria S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33 MMS2_k127_2784087_19 1304275.C41B8_18592 1.862e-132 437.0 COG0477@1|root,COG2814@2|Bacteria,1QUD1@1224|Proteobacteria,1RQ0V@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 MMS2_k127_2784087_38 999541.bgla_2g17310 5.903e-53 192.0 COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,2VUD7@28216|Betaproteobacteria,1KASE@119060|Burkholderiaceae 28216|Betaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2784087_25 1231391.AMZF01000019_gene2019 3.995e-107 353.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,3T2P4@506|Alcaligenaceae 1224|Proteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf MMS2_k127_2784087_45 1210884.HG799463_gene9610 4.51e-37 144.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2784087_16 870187.Thini_1164 2.177e-147 480.0 COG2270@1|root,COG2270@2|Bacteria,1MWXB@1224|Proteobacteria,1S03J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 MMS2_k127_2784087_49 1121116.KB894765_gene951 6.21e-21 99.0 29YIQ@1|root,30KDU@2|Bacteria,1Q0IY@1224|Proteobacteria,2W5DA@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative bacterial sensory transduction regulator - - - - - - - - - - - - YbjN MMS2_k127_2784087_0 519989.ECTPHS_12545 0.0 1126.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig MMS2_k127_2784087_24 1255043.TVNIR_2914 1.838e-107 356.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WXNB@135613|Chromatiales 135613|Chromatiales BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl MMS2_k127_2784087_31 408672.NBCG_01059 1.511e-80 283.0 COG2962@1|root,COG2962@2|Bacteria,2GKCP@201174|Actinobacteria,4DN8G@85009|Propionibacteriales 201174|Actinobacteria S EamA-like transporter family rarD - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA MMS2_k127_2784087_40 757424.Hsero_3172 4.736e-48 180.0 COG0563@1|root,COG0563@2|Bacteria,1N0HQ@1224|Proteobacteria,2VRGV@28216|Betaproteobacteria 28216|Betaproteobacteria F COG0563 Adenylate kinase and related kinases - - - - - - - - - - - - - MMS2_k127_2784087_30 748658.KB907312_gene1416 1.715e-86 295.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,1S37E@1236|Gammaproteobacteria,1WWWB@135613|Chromatiales 135613|Chromatiales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA MMS2_k127_2784087_12 1049564.TevJSym_cl00010 4.23e-165 533.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1,Thioredoxin_4 MMS2_k127_2784087_51 1123237.Salmuc_03298 8.388e-06 56.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg MMS2_k127_2784087_39 1198232.CYCME_0186 2.911e-49 183.0 COG3663@1|root,COG3663@2|Bacteria,1RAVZ@1224|Proteobacteria,1S2GN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells mug - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG MMS2_k127_2784087_2 519989.ECTPHS_05430 1.813e-236 740.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales 135613|Chromatiales C FAD linked oxidase - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 MMS2_k127_2784087_20 1123368.AUIS01000005_gene484 1.924e-127 422.0 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,2NC9T@225057|Acidithiobacillales 225057|Acidithiobacillales C FAD binding domain glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 MMS2_k127_2784087_8 1123368.AUIS01000005_gene483 5.903e-188 595.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales 225057|Acidithiobacillales C 4Fe-4S dicluster domain glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 MMS2_k127_2784087_9 1265505.ATUG01000003_gene790 2.034e-175 568.0 COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,43CS0@68525|delta/epsilon subdivisions,2X7ZM@28221|Deltaproteobacteria,2MNZV@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF MMS2_k127_2784087_36 349521.HCH_00228 8.136e-59 207.0 COG0454@1|root,COG0456@2|Bacteria,1QU0C@1224|Proteobacteria,1S503@1236|Gammaproteobacteria,1XKTZ@135619|Oceanospirillales 135619|Oceanospirillales K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_2784087_47 426114.THI_0822 1.627e-30 126.0 COG4968@1|root,COG4968@2|Bacteria,1N31J@1224|Proteobacteria,2W36P@28216|Betaproteobacteria,1KNSV@119065|unclassified Burkholderiales 28216|Betaproteobacteria U Prokaryotic N-terminal methylation motif - - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl MMS2_k127_2784087_23 1085623.GNIT_0161 1.653e-116 409.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,MASE3,PAS_4,PAS_8,PAS_9,SBP_bac_3 MMS2_k127_2784087_10 640511.BC1002_3545 1.797e-167 534.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1K4SR@119060|Burkholderiaceae 28216|Betaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K02346,ko:K03502 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH MMS2_k127_2784087_32 338969.Rfer_1387 1.342e-78 267.0 COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,2VQSG@28216|Betaproteobacteria,4AEAD@80864|Comamonadaceae 28216|Betaproteobacteria S Flavodoxin-like fold - - - - - - - - - - - - Flavodoxin_2 MMS2_k127_2784087_21 1168067.JAGP01000001_gene1968 1.577e-125 409.0 COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,1RSF8@1236|Gammaproteobacteria,46155@72273|Thiotrichales 72273|Thiotrichales EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_2784087_27 706587.Desti_2020 1.547e-96 322.0 COG1028@1|root,COG1028@2|Bacteria,1MUAY@1224|Proteobacteria,42NIM@68525|delta/epsilon subdivisions,2WMK8@28221|Deltaproteobacteria,2MR0R@213462|Syntrophobacterales 28221|Deltaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 MMS2_k127_2784087_46 396588.Tgr7_1283 4.345e-36 141.0 COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1WYG0@135613|Chromatiales 135613|Chromatiales N Host attachment protein - - - - - - - - - - - - Host_attach MMS2_k127_2784087_1 396588.Tgr7_0259 8.521e-299 936.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C MMS2_k127_2784087_52 591157.SSLG_02679 0.0001484 47.0 2A23H@1|root,30QDR@2|Bacteria,2GPZM@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - MMS2_k127_2784087_4 1499686.BN1079_02375 1.494e-230 724.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.54,1.2.1.99 ko:K09472,ko:K12254 ko00330,ko01100,map00330,map01100 M00136 R02549,R03177,R07417,R07418 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS2_k127_2784087_34 1192124.LIG30_3796 2.543e-65 228.0 COG0662@1|root,COG1476@1|root,COG0662@2|Bacteria,COG1476@2|Bacteria,1QTWE@1224|Proteobacteria,2VQIT@28216|Betaproteobacteria,1K47B@119060|Burkholderiaceae 28216|Betaproteobacteria K Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 MMS2_k127_2784087_6 251229.Chro_2778 1.369e-206 651.0 COG0161@1|root,COG0161@2|Bacteria,1G1QE@1117|Cyanobacteria,3VJI9@52604|Pleurocapsales 1117|Cyanobacteria H Aminotransferase class-III bioA - 2.6.1.18,2.6.1.62 ko:K00822,ko:K00833 ko00280,ko00410,ko00640,ko00780,ko01100,map00280,map00410,map00640,map00780,map01100 M00123,M00573,M00577 R00907,R03231,R04187 RC00006,RC00008,RC00062,RC00160,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 MMS2_k127_2861448_21 1041147.AUFB01000006_gene2349 8.313e-70 238.0 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2U7B2@28211|Alphaproteobacteria,4BDRS@82115|Rhizobiaceae 28211|Alphaproteobacteria K transcriptional putR - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type MMS2_k127_2861448_24 396588.Tgr7_2161 1.43e-58 220.0 COG2206@1|root,COG2206@2|Bacteria,1MWDU@1224|Proteobacteria,1S7D9@1236|Gammaproteobacteria,1X108@135613|Chromatiales 135613|Chromatiales T HD domain - - - - - - - - - - - - HD_5 MMS2_k127_2861448_3 243159.AFE_2799 9.241e-187 595.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria,2NC9W@225057|Acidithiobacillales 225057|Acidithiobacillales K AraC type - - 3.2.2.21 ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD MMS2_k127_2861448_26 483219.LILAB_20735 2.207e-55 209.0 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,42TN9@68525|delta/epsilon subdivisions,2WRG0@28221|Deltaproteobacteria,2Z0S2@29|Myxococcales 28221|Deltaproteobacteria H Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N MMS2_k127_2861448_33 1123242.JH636438_gene5722 1.483e-29 121.0 COG4994@1|root,COG4994@2|Bacteria 2|Bacteria K Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - DUF4440 MMS2_k127_2861448_7 1005048.CFU_1248 1.391e-146 478.0 COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,2VMD4@28216|Betaproteobacteria,475P8@75682|Oxalobacteraceae 28216|Betaproteobacteria EGP Major facilitator superfamily - - - ko:K08169 - - - - ko00000,ko02000 2.A.1.3.17 - - MFS_1 MMS2_k127_2861448_16 196367.JNFG01000020_gene4680 1.844e-112 366.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria,1K5MN@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short,adh_short_C2 MMS2_k127_2861448_5 82996.sch_13175 4.005e-152 486.0 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,1RPUF@1236|Gammaproteobacteria,400X6@613|Serratia 1236|Gammaproteobacteria K Transcriptional regulator nodD2 - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2861448_35 596151.DesfrDRAFT_3396 7.952e-06 49.0 COG1335@1|root,COG1335@2|Bacteria,1MV0W@1224|Proteobacteria,42ZI3@68525|delta/epsilon subdivisions,2WV4G@28221|Deltaproteobacteria,2MF66@213115|Desulfovibrionales 28221|Deltaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase MMS2_k127_2861448_6 402626.Rpic_3819 1.317e-150 493.0 COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2VMKZ@28216|Betaproteobacteria,1KGUB@119060|Burkholderiaceae 28216|Betaproteobacteria EGP PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 MMS2_k127_2861448_25 1123257.AUFV01000010_gene3322 7.102e-56 208.0 2CVTP@1|root,32SY9@2|Bacteria,1N209@1224|Proteobacteria,1S8YX@1236|Gammaproteobacteria,1X7EG@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1203) - - - - - - - - - - - - DUF1203 MMS2_k127_2861448_19 1121127.JAFA01000021_gene8014 9.861e-88 307.0 COG0640@1|root,COG0640@2|Bacteria,1MWCW@1224|Proteobacteria,2VP44@28216|Betaproteobacteria,1K3EY@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 MMS2_k127_2861448_4 864069.MicloDRAFT_00016540 1.314e-169 538.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,1JT1V@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM aldo keto reductase - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red MMS2_k127_2861448_10 1304275.C41B8_18211 4.886e-133 432.0 COG2113@1|root,COG2113@2|Bacteria,1MVIG@1224|Proteobacteria,1RRNK@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glycine, betaine - - - ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC MMS2_k127_2861448_27 1380394.JADL01000004_gene6002 7.858e-54 196.0 COG1309@1|root,COG1309@2|Bacteria,1MX72@1224|Proteobacteria,2U5RY@28211|Alphaproteobacteria,2JSWJ@204441|Rhodospirillales 204441|Rhodospirillales K Repressor involved in choline regulation of the bet genes betI - - ko:K02167 - - - - ko00000,ko03000 - - - TetR_C_6,TetR_N MMS2_k127_2861448_1 1238182.C882_0162 7.085e-218 695.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPZI@204441|Rhodospirillales 204441|Rhodospirillales C belongs to the aldehyde dehydrogenase family betB - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS2_k127_2861448_0 717785.HYPMC_1874 4.877e-244 767.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3N6B8@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N MMS2_k127_2861448_13 1144275.COCOR_03133 6.959e-121 396.0 COG0583@1|root,COG0583@2|Bacteria,1MU4C@1224|Proteobacteria,437SW@68525|delta/epsilon subdivisions,2X322@28221|Deltaproteobacteria,2YTZU@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2861448_9 543728.Vapar_4753 5.734e-143 472.0 COG0477@1|root,COG2814@2|Bacteria,1MVVW@1224|Proteobacteria,2VIUY@28216|Betaproteobacteria,4ABAI@80864|Comamonadaceae 28216|Betaproteobacteria EGP PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1,Sugar_tr MMS2_k127_2861448_12 438753.AZC_2181 1.515e-122 399.0 COG0583@1|root,COG0583@2|Bacteria,1NUAB@1224|Proteobacteria,2TUCY@28211|Alphaproteobacteria,3EZXI@335928|Xanthobacteraceae 28211|Alphaproteobacteria K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_2861448_28 439375.Oant_0421 3.26e-44 165.0 COG1380@1|root,COG1380@2|Bacteria,1N79K@1224|Proteobacteria,2UC4Y@28211|Alphaproteobacteria,1J306@118882|Brucellaceae 28211|Alphaproteobacteria S LrgA family - - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA MMS2_k127_2861448_18 288000.BBta_7210 6.864e-100 331.0 COG1346@1|root,COG1346@2|Bacteria,1MXJR@1224|Proteobacteria,2VGCP@28211|Alphaproteobacteria,3K6IW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - LrgB MMS2_k127_2861448_32 224914.BMEI1597 1.77e-35 139.0 COG1380@1|root,COG1380@2|Bacteria,1N79K@1224|Proteobacteria,2UC4Y@28211|Alphaproteobacteria,1J306@118882|Brucellaceae 28211|Alphaproteobacteria S LrgA family - - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA MMS2_k127_2861448_23 1437448.AZRT01000029_gene2450 1.834e-69 243.0 COG1346@1|root,COG1346@2|Bacteria,1MXJR@1224|Proteobacteria,2VGCP@28211|Alphaproteobacteria,1J1QX@118882|Brucellaceae 28211|Alphaproteobacteria M LrgB-like family - - - - - - - - - - - - LrgB MMS2_k127_2861448_17 1174504.AJTN02000207_gene3329 5.162e-104 361.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,1ZBA4@1386|Bacillus 91061|Bacilli E Belongs to the ABC transporter superfamily - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY MMS2_k127_2861448_15 867903.ThesuDRAFT_01077 3e-113 385.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WCYH@538999|Clostridiales incertae sedis 186801|Clostridia EP Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY MMS2_k127_2861448_8 1380394.JADL01000003_gene5175 1.028e-144 466.0 COG2421@1|root,COG2421@2|Bacteria,1MXKY@1224|Proteobacteria,2TSVA@28211|Alphaproteobacteria,2JR7H@204441|Rhodospirillales 204441|Rhodospirillales C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA MMS2_k127_2861448_2 1116369.KB890024_gene4841 9.761e-211 685.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,43IIH@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 MMS2_k127_2861448_11 1123366.TH3_19277 2.012e-124 407.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,2JRDS@204441|Rhodospirillales 204441|Rhodospirillales P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS2_k127_2861448_14 1353537.TP2_04890 1.958e-115 378.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TTEV@28211|Alphaproteobacteria,2XM4V@285107|Thioclava 28211|Alphaproteobacteria U N-terminal TM domain of oligopeptide transport permease C - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N MMS2_k127_2861448_36 1123519.PSJM300_10000 0.0007427 42.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,1S3XS@1236|Gammaproteobacteria,1Z2Q8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E threonine efflux protein - - - - - - - - - - - - LysE MMS2_k127_2861448_34 582744.Msip34_2581 2.589e-06 59.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,2KMED@206350|Nitrosomonadales 206350|Nitrosomonadales M TIGRFAM TonB family - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C MMS2_k127_2861448_29 1288494.EBAPG3_1600 6.649e-41 157.0 COG0848@1|root,COG0848@2|Bacteria,1RHHU@1224|Proteobacteria,2VVGZ@28216|Betaproteobacteria,3739A@32003|Nitrosomonadales 28216|Betaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD MMS2_k127_2861448_22 261292.Nit79A3_3225 1.091e-69 242.0 COG0811@1|root,COG0811@2|Bacteria,1RCVA@1224|Proteobacteria,2VT3Q@28216|Betaproteobacteria,372KZ@32003|Nitrosomonadales 28216|Betaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB MMS2_k127_2861448_20 706587.Desti_3351 1.03e-75 264.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,42SPM@68525|delta/epsilon subdivisions,2WMYY@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIGRFAM channel protein, hemolysin III family - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII MMS2_k127_2861448_30 396588.Tgr7_1062 9.963e-41 156.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,1S9FV@1236|Gammaproteobacteria,1WYWP@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0225 family - - - ko:K09858 - - - - ko00000 - - - SEC-C MMS2_k127_2861448_31 555778.Hneap_1706 2.65e-38 145.0 COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,1SAV8@1236|Gammaproteobacteria,1WZPV@135613|Chromatiales 135613|Chromatiales S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP MMS2_k127_2931076_0 1163407.UU7_08768 2.874e-128 415.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1X4XZ@135614|Xanthomonadales 135614|Xanthomonadales M mechanosensitive ion channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix MMS2_k127_2931076_1 666685.R2APBS1_3457 6.003e-121 391.0 COG0308@1|root,COG1277@1|root,COG0308@2|Bacteria,COG1277@2|Bacteria,1PTWJ@1224|Proteobacteria,1RZH5@1236|Gammaproteobacteria,1X55X@135614|Xanthomonadales 135614|Xanthomonadales E Peptidase family M1 domain - - - - - - - - - - - - ABC2_membrane_2,Peptidase_M1 MMS2_k127_3020496_2 765698.Mesci_2885 4.669e-128 412.0 COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,2TU3Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the iron ascorbate-dependent oxidoreductase family - - - - - - - - - - - - 2OG-FeII_Oxy,DIOX_N MMS2_k127_3020496_1 926560.KE387026_gene4262 3.842e-147 482.0 COG0402@1|root,COG0402@2|Bacteria 2|Bacteria F S-adenosylhomocysteine deaminase activity codA GO:0003674,GO:0003824,GO:0004131,GO:0005488,GO:0005506,GO:0005515,GO:0006139,GO:0006206,GO:0006208,GO:0006209,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019439,GO:0019858,GO:0034641,GO:0035888,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.4.1,3.5.4.21 ko:K01485,ko:K03365 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_0343,iEcSMS35_1347.EcSMS35_0368 Amidohydro_3 MMS2_k127_3020496_0 1163408.UU9_03692 3.471e-157 499.0 COG2866@1|root,COG2866@2|Bacteria,1MYRD@1224|Proteobacteria,1T1MH@1236|Gammaproteobacteria,1X3C7@135614|Xanthomonadales 135614|Xanthomonadales E Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA,DUF2817 MMS2_k127_3020496_3 582899.Hden_0082 1.765e-26 116.0 28IUB@1|root,2Z8T2@2|Bacteria,1N0PJ@1224|Proteobacteria,2U3CJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - 1.14.13.238 ko:K22344 - - - - ko00000,ko01000 - - - - MMS2_k127_3028448_6 243233.MCA1677 3.555e-47 171.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales 135618|Methylococcales F TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N MMS2_k127_3028448_2 713586.KB900536_gene2052 1.345e-135 442.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales 135613|Chromatiales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer MMS2_k127_3028448_7 1177181.T9A_00727 1.626e-26 110.0 COG0425@1|root,COG0425@2|Bacteria 2|Bacteria O sulfur carrier activity tusA - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA MMS2_k127_3028448_1 1283300.ATXB01000002_gene2659 1.264e-180 570.0 COG0482@1|root,COG0482@2|Bacteria,1QV6H@1224|Proteobacteria,1RQSV@1236|Gammaproteobacteria,1XH1D@135618|Methylococcales 135618|Methylococcales J Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - - MMS2_k127_3028448_8 472759.Nhal_3158 3.328e-18 88.0 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria,1X297@135613|Chromatiales 135613|Chromatiales H ThiS family - - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS MMS2_k127_3028448_3 396588.Tgr7_3236 1.24e-131 426.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1WW65@135613|Chromatiales 135613|Chromatiales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG MMS2_k127_3028448_4 396588.Tgr7_3237 1.619e-86 298.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1WY2P@135613|Chromatiales 135613|Chromatiales J catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 MMS2_k127_3028448_5 396588.Tgr7_0094 3.627e-70 256.0 COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1WW0P@135613|Chromatiales 135613|Chromatiales T TIGRFAM Diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF MMS2_k127_3028448_0 396588.Tgr7_0177 0.0 1066.0 COG0438@1|root,COG0438@2|Bacteria,1QZ01@1224|Proteobacteria,1RZJA@1236|Gammaproteobacteria,1X05E@135613|Chromatiales 135613|Chromatiales M sucrose synthase - - 2.4.1.13 ko:K00695 ko00500,ko01100,map00500,map01100 - R00806 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000,ko01003 - GT4 - Glycos_transf_1,Sucrose_synth MMS2_k127_3070922_18 1335757.SPICUR_06670 4.702e-15 86.0 COG4160@1|root,COG4160@2|Bacteria,1QV6B@1224|Proteobacteria,1RNC2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P (ABC) transporter occM1 - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 MMS2_k127_3070922_12 207954.MED92_09131 2.161e-74 256.0 COG4215@1|root,COG4215@2|Bacteria,1MY2N@1224|Proteobacteria,1SYC9@1236|Gammaproteobacteria,1XRJI@135619|Oceanospirillales 135619|Oceanospirillales P (ABC) transporter - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 MMS2_k127_3070922_7 743720.Psefu_0570 4.115e-97 324.0 COG0834@1|root,COG0834@2|Bacteria,1MXIA@1224|Proteobacteria,1RPXK@1236|Gammaproteobacteria,1YWUV@136845|Pseudomonas putida group 1236|Gammaproteobacteria ET PFAM Extracellular solute-binding protein, family 3 artJ - - ko:K02030,ko:K09996,ko:K10014,ko:K10022 ko02010,map02010 M00226,M00229,M00235,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.1,3.A.1.3.11,3.A.1.3.3 - - SBP_bac_3 MMS2_k127_3070922_3 1357279.N018_24805 8.482e-112 367.0 COG4598@1|root,COG4598@2|Bacteria,1QTS2@1224|Proteobacteria,1RQYN@1236|Gammaproteobacteria,1Z57M@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E ABC transporter, ATP-binding protein HA62_27665 - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran MMS2_k127_3070922_9 713586.KB900536_gene1722 1.682e-90 311.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria 1236|Gammaproteobacteria P 3'(2'),5'-bisphosphate nucleotidase cysQ GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - iAPECO1_1312.APECO1_2172,iE2348C_1286.E2348C_4545,iEC042_1314.EC042_4695,iEC55989_1330.EC55989_4774,iECABU_c1320.ECABU_c47840,iECIAI1_1343.ECIAI1_4448,iECIAI39_1322.ECIAI39_4686,iECO103_1326.ECO103_5013,iECO111_1330.ECO111_5101,iECO26_1355.ECO26_5384,iECOK1_1307.ECOK1_4735,iECP_1309.ECP_4468,iECSE_1348.ECSE_4520,iECSF_1327.ECSF_4108,iECUMN_1333.ECUMN_4751,iECW_1372.ECW_m4578,iEKO11_1354.EKO11_4094,iEcE24377_1341.EcE24377A_4785,iEcHS_1320.EcHS_A4468,iEcSMS35_1347.EcSMS35_4694,iLF82_1304.LF82_0422,iNRG857_1313.NRG857_21455,iSBO_1134.SBO_4229,iSDY_1059.SDY_4385,iSSON_1240.SSON_4399,iSbBS512_1146.SbBS512_E4758,iUMN146_1321.UM146_21355,iUTI89_1310.UTI89_C4823,iWFL_1372.ECW_m4578,ic_1306.c5313 Inositol_P MMS2_k127_3070922_10 396588.Tgr7_2931 2.288e-75 259.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1WXW6@135613|Chromatiales 135613|Chromatiales L PFAM NUDIX hydrolase nudE - - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX MMS2_k127_3070922_16 1049564.TevJSym_ac02000 1.374e-29 122.0 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1J6AD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808 FolB MMS2_k127_3070922_14 1318628.MARLIPOL_09716 2.034e-65 238.0 COG1234@1|root,COG1234@2|Bacteria,1R8CF@1224|Proteobacteria,1SF11@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Beta-lactamase - - - - - - - - - - - - Lactamase_B_2 MMS2_k127_3070922_20 572477.Alvin_1898 1.102e-06 59.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1WYQM@135613|Chromatiales 135613|Chromatiales H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK MMS2_k127_3070922_13 1304275.C41B8_01305 6.061e-73 255.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RPGM@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ reductase folM GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0055114,GO:0071172 1.5.1.3,1.5.1.33,1.5.1.50 ko:K03793,ko:K13938 ko00670,ko00790,ko01100,map00670,map00790,map01100 - R00936,R00939,R11019 RC00109,RC03327 ko00000,ko00001,ko01000 - - iECUMN_1333.ECUMN_1894 adh_short,adh_short_C2 MMS2_k127_3070922_4 396588.Tgr7_0329 4.38e-110 369.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales 135613|Chromatiales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 MMS2_k127_3070922_5 1026882.MAMP_01550 1.63e-102 339.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,4600I@72273|Thiotrichales 72273|Thiotrichales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA MMS2_k127_3070922_17 1116472.MGMO_17c00090 2.57e-27 121.0 COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,1S59S@1236|Gammaproteobacteria,1XFTG@135618|Methylococcales 135618|Methylococcales S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 MMS2_k127_3070922_8 1116472.MGMO_17c00080 3.435e-92 311.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1XF0D@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 MMS2_k127_3070922_19 666685.R2APBS1_2068 3.093e-13 75.0 COG5572@1|root,COG5572@2|Bacteria,1PCZH@1224|Proteobacteria,1S9EN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein - - - - - - - - - - - - DUF2282 MMS2_k127_3070922_11 1042163.BRLA_c020000 5.905e-75 263.0 COG0697@1|root,COG0697@2|Bacteria,1TRH8@1239|Firmicutes,4HFDU@91061|Bacilli,26QGQ@186822|Paenibacillaceae 91061|Bacilli EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_3070922_2 1158150.KB906241_gene1030 2.376e-151 487.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales 135613|Chromatiales H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase MMS2_k127_3070922_6 519989.ECTPHS_13492 4.006e-97 319.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 MMS2_k127_3070922_1 713586.KB900536_gene2412 1.364e-164 528.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM MMS2_k127_3070922_15 396588.Tgr7_0269 1.279e-40 168.0 COG3288@1|root,COG3288@2|Bacteria,1N0TD@1224|Proteobacteria,1SA8D@1236|Gammaproteobacteria,1X1J6@135613|Chromatiales 135613|Chromatiales C 4TM region of pyridine nucleotide transhydrogenase, mitoch - - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB_4TM MMS2_k127_3070922_0 1255043.TVNIR_3552 6.677e-220 689.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB MMS2_k127_3073423_2 321327.CYA_1541 8.506e-05 49.0 COG0664@1|root,COG0664@2|Bacteria,1G5XZ@1117|Cyanobacteria,1H00M@1129|Synechococcus 1117|Cyanobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases cysR - - - - - - - - - - - HTH_Crp_2,PAS,cNMP_binding MMS2_k127_3073423_1 555778.Hneap_0972 6.939e-153 484.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1WXCM@135613|Chromatiales 135613|Chromatiales S PFAM Polyphosphate kinase 2 - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 MMS2_k127_3073423_0 555778.Hneap_0971 2.584e-247 782.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6 ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase MMS2_k127_3099781_11 631362.Thi970DRAFT_04738 7.752e-42 160.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1WXJP@135613|Chromatiales 135613|Chromatiales M PFAM glycosyl transferase family 39 - - - - - - - - - - - - PMT_2 MMS2_k127_3099781_10 1163617.SCD_n01748 6.823e-48 183.0 COG0671@1|root,COG0671@2|Bacteria,1NAJ7@1224|Proteobacteria,2VX11@28216|Betaproteobacteria 28216|Betaproteobacteria I Acid phosphatase homologues - - - - - - - - - - - - PAP2 MMS2_k127_3099781_1 105559.Nwat_1588 1.018e-117 393.0 COG0477@1|root,COG0477@2|Bacteria,1QTUM@1224|Proteobacteria,1T1HT@1236|Gammaproteobacteria,1WW5Z@135613|Chromatiales 135613|Chromatiales EGP PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr MMS2_k127_3099781_14 314278.NB231_06960 8.245e-29 126.0 COG2761@1|root,COG2761@2|Bacteria 2|Bacteria Q protein disulfide oxidoreductase activity - - - - - - - - - - - - DSBA MMS2_k127_3099781_16 314345.SPV1_14174 1.056e-15 81.0 2CEDU@1|root,333S9@2|Bacteria,1NCM4@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4156) - - - - - - - - - - - - DUF4156 MMS2_k127_3099781_15 1049564.TevJSym_be00330 3.397e-27 120.0 COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria,1RQR9@1236|Gammaproteobacteria,1J6IN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S outer membrane lipoprotein - - - - - - - - - - - - Rick_17kDa_Anti MMS2_k127_3099781_20 314278.NB231_00560 4.166e-05 50.0 2DCHX@1|root,2ZE7T@2|Bacteria,1PBCP@1224|Proteobacteria,1SU6U@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3099781_4 1122604.JONR01000014_gene208 2.055e-87 304.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C MMS2_k127_3099781_2 314278.NB231_00570 2.252e-107 365.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,1X2PT@135613|Chromatiales 135613|Chromatiales T GHKL domain - - - - - - - - - - - - HATPase_c MMS2_k127_3099781_18 675817.VDA_002217 2.268e-05 54.0 2C5Z0@1|root,32Z72@2|Bacteria,1NCMK@1224|Proteobacteria,1SENZ@1236|Gammaproteobacteria,1XX9G@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - MMS2_k127_3099781_7 926550.CLDAP_06540 5.715e-54 201.0 COG1985@1|root,COG1985@2|Bacteria 2|Bacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate - - - - - - - - - - - - RibD_C MMS2_k127_3099781_13 1123368.AUIS01000018_gene713 2.942e-30 126.0 COG0607@1|root,COG0607@2|Bacteria,1RKAQ@1224|Proteobacteria,1SFYV@1236|Gammaproteobacteria,2NCYT@225057|Acidithiobacillales 225057|Acidithiobacillales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese MMS2_k127_3099781_3 748247.AZKH_1688 4.081e-104 349.0 COG2837@1|root,COG2837@2|Bacteria,1MWDD@1224|Proteobacteria,2VKMS@28216|Betaproteobacteria 28216|Betaproteobacteria C Dyp-type peroxidase family dyp - - ko:K07223 - - - - ko00000 - - - Dyp_perox MMS2_k127_3099781_5 523791.Kkor_0588 2.99e-69 252.0 COG2829@1|root,COG2829@2|Bacteria,1PC8I@1224|Proteobacteria,1RMJH@1236|Gammaproteobacteria,1XHTX@135619|Oceanospirillales 135619|Oceanospirillales M Phospholipase pldA - 3.1.1.32,3.1.1.4 ko:K01058 ko00564,ko00565,ko00590,ko00591,ko00592,ko01100,ko01110,map00564,map00565,map00590,map00591,map00592,map01100,map01110 - R01315,R01316,R01317,R02053,R02054,R04034,R07064,R07379,R07387,R07859,R07860 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko01000 - - - PLA1 MMS2_k127_3099781_8 1397284.AYMN01000117_gene4043 4.507e-52 194.0 COG0346@1|root,COG0346@2|Bacteria,1RGVH@1224|Proteobacteria,1S6CP@1236|Gammaproteobacteria,403G8@613|Serratia 1236|Gammaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase yycE - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Glyoxalase MMS2_k127_3099781_9 204773.HEAR0065 3.503e-50 184.0 COG2050@1|root,COG2050@2|Bacteria,1QU0P@1224|Proteobacteria,2VTB0@28216|Betaproteobacteria,4775A@75682|Oxalobacteraceae 28216|Betaproteobacteria Q Putative thioesterase (yiiD_Cterm) - - - - - - - - - - - - YiiD_C MMS2_k127_3099781_0 1333856.L686_08185 5.12e-127 414.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1Z063@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases ppsC - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 MMS2_k127_3099781_6 1168067.JAGP01000001_gene1681 4.133e-66 227.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1SBAP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP MMS2_k127_3099781_12 1123487.KB892857_gene2318 2.182e-38 153.0 COG2353@1|root,COG2353@2|Bacteria,1N3P9@1224|Proteobacteria,2VSMB@28216|Betaproteobacteria,2KZ87@206389|Rhodocyclales 206389|Rhodocyclales S YceI-like domain - - - - - - - - - - - - YceI MMS2_k127_3099781_19 349124.Hhal_0073 3.68e-05 49.0 COG1495@1|root,COG1495@2|Bacteria 2|Bacteria O protein disulfide oxidoreductase activity dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB MMS2_k127_3106165_7 765913.ThidrDRAFT_0972 3.357e-58 211.0 COG3233@1|root,COG3233@2|Bacteria,1R97C@1224|Proteobacteria,1RQCC@1236|Gammaproteobacteria,1WWWG@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2334) - - - ko:K06986 - - - - ko00000 - - - DUF2334 MMS2_k127_3106165_4 1249627.D779_0139 3.673e-88 305.0 COG0438@1|root,COG0438@2|Bacteria,1NMB5@1224|Proteobacteria,1RYZ0@1236|Gammaproteobacteria,1WW25@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS2_k127_3106165_2 1000565.METUNv1_02201 5.294e-139 471.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,PAS,PAS_4 MMS2_k127_3106165_8 1123367.C666_15480 2.933e-37 152.0 COG3194@1|root,COG3194@2|Bacteria,1RH5G@1224|Proteobacteria,2VT31@28216|Betaproteobacteria,2KWU3@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source allA - 4.3.2.3 ko:K01483 ko00230,ko01100,map00230,map01100 - R00776 RC00153,RC00379 ko00000,ko00001,ko01000 - - - Ureidogly_lyase MMS2_k127_3106165_3 1396858.Q666_01365 4.365e-127 416.0 COG4266@1|root,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,1RR90@1236|Gammaproteobacteria,469CD@72275|Alteromonadaceae 1236|Gammaproteobacteria F Allantoicase repeat alc - 3.5.3.4 ko:K01477 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02422 RC00379,RC00712 ko00000,ko00001,ko00002,ko01000 - - - Allantoicase MMS2_k127_3106165_0 1403819.BATR01000162_gene5363 1.075e-151 497.0 COG0726@1|root,COG0726@2|Bacteria 2|Bacteria G polysaccharide deacetylase cda1 - 3.5.1.41,3.5.2.5 ko:K01452,ko:K16842 ko00230,ko00520,ko01100,ko01120,map00230,map00520,map01100,map01120 M00546 R02333,R02425 RC00166,RC00300,RC00680 ko00000,ko00001,ko00002,ko01000 - - - Polysacc_deac_1 MMS2_k127_3106165_5 768066.HELO_1596 4.208e-85 289.0 COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,1RQXU@1236|Gammaproteobacteria,1XJPJ@135619|Oceanospirillales 135619|Oceanospirillales E Racemase - - 5.1.99.3 ko:K16841 ko00230,ko01120,map00230,map01120 - R03925 RC01027 ko00000,ko00001,ko01000 - - - Asp_Glu_race MMS2_k127_3106165_6 216142.LT40_04525 8.209e-64 226.0 COG1802@1|root,COG1802@2|Bacteria,1R96W@1224|Proteobacteria,1S4ZM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - FCD,GntR MMS2_k127_3106165_1 1408418.JNJH01000030_gene2357 1.459e-139 449.0 COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,2TRTH@28211|Alphaproteobacteria,2JQFW@204441|Rhodospirillales 204441|Rhodospirillales FH Permease for cytosine/purines, uracil, thiamine, allantoin - - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur MMS2_k127_3108011_0 713586.KB900536_gene1821 2.885e-74 260.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 MMS2_k127_3108011_1 323261.Noc_3048 1.888e-26 114.0 COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1X1FG@135613|Chromatiales 135613|Chromatiales S Integral membrane protein (DUF2244) - - - - - - - - - - - - DUF2244 MMS2_k127_3113713_12 1157708.KB907454_gene2917 1.588e-75 263.0 COG3391@1|root,COG3391@2|Bacteria,1R25C@1224|Proteobacteria,2WIAZ@28216|Betaproteobacteria 28216|Betaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - - MMS2_k127_3113713_10 1120999.JONM01000002_gene725 1.043e-81 281.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VIEQ@28216|Betaproteobacteria,2KQQI@206351|Neisseriales 206351|Neisseriales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_3113713_6 859657.RPSI07_3285 7.844e-129 421.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,1K09X@119060|Burkholderiaceae 28216|Betaproteobacteria E Methylenetetrahydrofolate reductase metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR MMS2_k127_3113713_0 243233.MCA0138 2.073e-253 788.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1XDX9@135618|Methylococcales 135618|Methylococcales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD MMS2_k127_3113713_1 1026882.MAMP_01739 2.186e-206 648.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,45ZZ4@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N MMS2_k127_3113713_15 1248232.BANQ01000020_gene144 2.472e-26 113.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1Y0TC@135623|Vibrionales 135623|Vibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - - - - - - - - - - Oxidored_q4 MMS2_k127_3113713_11 314292.VAS14_05773 9.137e-77 264.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1XZZ9@135623|Vibrionales 135623|Vibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - - - - - - - - - - - Oxidored_q6 MMS2_k127_3113713_3 338963.Pcar_0206 5.687e-176 578.0 COG0377@1|root,COG0649@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,43S0B@69541|Desulfuromonadales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoBCD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K13378,ko:K13380 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,Oxidored_q6 MMS2_k127_3113713_14 314292.VAS14_05783 3.98e-46 171.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1Y268@135623|Vibrionales 135623|Vibrionales C Thioredoxin-like [2Fe-2S] ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx MMS2_k127_3113713_5 1248232.BANQ01000020_gene140 2.178e-169 549.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1XVQD@135623|Vibrionales 135623|Vibrionales C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S,SLBB MMS2_k127_3113713_4 314292.VAS14_05793 9.323e-173 569.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1Y0KI@135623|Vibrionales 135623|Vibrionales C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - - - - - - - - - - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3 MMS2_k127_3113713_8 1248232.BANQ01000020_gene138 1.157e-125 442.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1Y08F@135623|Vibrionales 135623|Vibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - - - - - - - - - - - NADHdh MMS2_k127_3113713_13 1248232.BANQ01000020_gene137 1.79e-72 248.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1Y0GZ@135623|Vibrionales 135623|Vibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - - - - - - - - - - - Fer4 MMS2_k127_3113713_16 1109445.AGSX01000195_gene523 4.248e-20 98.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1Z2IN@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C NADH ubiquinone oxidoreductase subunit nuoJ GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821 Oxidored_q3 MMS2_k127_3113713_17 314292.VAS14_05813 1.126e-16 87.0 COG0713@1|root,COG0713@2|Bacteria,1NJIE@1224|Proteobacteria,1TJC5@1236|Gammaproteobacteria,1Y0ZV@135623|Vibrionales 135623|Vibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - - - - - - - - - - - Oxidored_q2 MMS2_k127_3113713_2 637390.AFOH01000106_gene121 5.942e-199 643.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,2NCNU@225057|Acidithiobacillales 225057|Acidithiobacillales CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N MMS2_k127_3113713_7 314292.VAS14_05823 7.157e-127 422.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1Y25N@135623|Vibrionales 135623|Vibrionales C Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M MMS2_k127_3113713_9 314292.VAS14_05828 2.027e-104 357.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1XZZD@135623|Vibrionales 135623|Vibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - - - - - - - - - - - Proton_antipo_M MMS2_k127_3116124_3 472759.Nhal_0217 3.514e-123 428.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1WWU1@135613|Chromatiales 135613|Chromatiales S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB MMS2_k127_3116124_5 765911.Thivi_0099 9.783e-92 309.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase MMS2_k127_3116124_4 713586.KB900536_gene2942 5.612e-100 332.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf MMS2_k127_3116124_6 396588.Tgr7_0880 3.047e-88 297.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1X2ET@135613|Chromatiales 135613|Chromatiales F Deoxynucleoside kinase - - - - - - - - - - - - dNK MMS2_k127_3116124_10 1122194.AUHU01000004_gene1236 8.811e-57 202.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,467BR@72275|Alteromonadaceae 1236|Gammaproteobacteria H COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase folK GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131 HPPK MMS2_k127_3116124_0 519989.ECTPHS_00310 3.152e-179 572.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales 135613|Chromatiales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C MMS2_k127_3116124_15 1408444.JHYC01000008_gene1427 0.0001477 46.0 2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3116124_13 390989.JOEG01000004_gene3744 4.656e-26 113.0 2E4H1@1|root,319UY@2|Bacteria,2HU4U@201174|Actinobacteria,4DKV1@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - MMS2_k127_3116124_2 1123229.AUBC01000005_gene756 3.106e-127 419.0 COG0738@1|root,COG0738@2|Bacteria,1NEH4@1224|Proteobacteria,2UH8A@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - - MMS2_k127_3116124_1 177437.HRM2_33900 1.997e-133 437.0 COG0477@1|root,COG2814@2|Bacteria,1PEB2@1224|Proteobacteria,42RHX@68525|delta/epsilon subdivisions,2WNGH@28221|Deltaproteobacteria,2MJYW@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1 MMS2_k127_3116124_12 396595.TK90_2048 1.966e-35 138.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales 135613|Chromatiales J Belongs to the HSP15 family - - - ko:K04762 - - - - ko00000,ko03110 - - - S4 MMS2_k127_3116124_8 396588.Tgr7_0885 2.711e-71 254.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1S6AG@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 MMS2_k127_3116124_7 713586.KB900536_gene2947 4.078e-74 260.0 COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,1S3X1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050664,GO:0051287,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 - ko:K06955 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 MMS2_k127_3116124_9 1279017.AQYJ01000022_gene2731 2.561e-60 216.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,46785@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0260 family ycgN - - ko:K09160 - - - - ko00000 - - - CxxCxxCC MMS2_k127_3116124_11 396588.Tgr7_0870 5.576e-56 207.0 COG1519@1|root,COG1519@2|Bacteria,1NY0P@1224|Proteobacteria,1SPRR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - - MMS2_k127_3116124_14 558884.JRGM01000135_gene1195 4.872e-05 46.0 COG0748@1|root,COG0748@2|Bacteria,1REH2@1224|Proteobacteria,1S83M@1236|Gammaproteobacteria,1Y5M4@135624|Aeromonadales 135624|Aeromonadales P Pfam:Pyridox_oxidase - - - ko:K07226 - - - - ko00000 - - - Putative_PNPOx MMS2_k127_3134979_1 1234364.AMSF01000088_gene2763 6.372e-110 361.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1X4VN@135614|Xanthomonadales 135614|Xanthomonadales D Reduces the stability of FtsZ polymers in the presence of ATP zapE - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase MMS2_k127_3134979_0 396588.Tgr7_3178 4.281e-165 540.0 COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,1X04N@135613|Chromatiales 135613|Chromatiales G PFAM Pyruvate kinase barrel - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK MMS2_k127_3134979_2 396588.Tgr7_3177 1.398e-30 133.0 COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria 1224|Proteobacteria S PFAM CHAD domain containing protein - - - - - - - - - - - - CHAD MMS2_k127_3135730_20 1003200.AXXA_15317 0.0001207 47.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKCY@28216|Betaproteobacteria,3T3CF@506|Alcaligenaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC MMS2_k127_3135730_9 1131814.JAFO01000001_gene3989 7.646e-110 371.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,3F14T@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Malate/L-lactate dehydrogenase - - 1.1.1.338 ko:K16844 ko00270,ko01120,map00270,map01120 - R07137 RC00031 ko00000,ko00001,ko01000 - - - Ldh_2 MMS2_k127_3135730_8 563192.HMPREF0179_00430 1.12e-112 371.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2M9SI@213115|Desulfovibrionales 28221|Deltaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase catalytic region serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT MMS2_k127_3135730_0 1304275.C41B8_03641 5.26e-219 683.0 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,1RQ9E@1236|Gammaproteobacteria 1236|Gammaproteobacteria G D-galactarate dehydratase / Altronate hydrolase, C terminus - - 4.2.1.7,4.4.1.24 ko:K16846,ko:K16850 ko00040,ko00270,ko01100,map00040,map00270,map01100 M00631 R01540,R07633 RC00543,RC01785 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C MMS2_k127_3135730_18 1304275.C41B8_03646 4.231e-41 153.0 COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria,1SA6E@1236|Gammaproteobacteria 1236|Gammaproteobacteria G SAF - - 4.4.1.24 ko:K16845 ko00270,map00270 - R07633 RC01785 ko00000,ko00001,ko01000 - - - SAF MMS2_k127_3135730_13 1304275.C41B8_03651 6.863e-86 291.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,1RYZ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator GntR family - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA MMS2_k127_3135730_11 105559.Nwat_2718 5.493e-108 360.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1WVZX@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 MMS2_k127_3135730_15 1137799.GZ78_02980 2.298e-84 284.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1XIJW@135619|Oceanospirillales 135619|Oceanospirillales H catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI MMS2_k127_3135730_16 1123504.JQKD01000017_gene1797 1.253e-75 262.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2VN1A@28216|Betaproteobacteria,4ACMX@80864|Comamonadaceae 28216|Betaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos MMS2_k127_3135730_4 1408418.JNJH01000067_gene755 8.432e-128 422.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQAD@204441|Rhodospirillales 204441|Rhodospirillales E TOBE domain - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 MMS2_k127_3135730_6 1408418.JNJH01000067_gene754 1.161e-117 397.0 COG1177@1|root,COG1177@2|Bacteria,1MV4A@1224|Proteobacteria,2TUA3@28211|Alphaproteobacteria,2JSSN@204441|Rhodospirillales 204441|Rhodospirillales E Binding-protein-dependent transport system inner membrane component - - - ko:K02053 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 MMS2_k127_3135730_5 1408418.JNJH01000067_gene753 7.255e-126 408.0 COG4132@1|root,COG4132@2|Bacteria,1NF20@1224|Proteobacteria,2U0S4@28211|Alphaproteobacteria,2JSH8@204441|Rhodospirillales 204441|Rhodospirillales P Binding-protein-dependent transport system inner membrane component - - - ko:K02054 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - BPD_transp_1 MMS2_k127_3135730_1 349163.Acry_0984 3.187e-155 500.0 COG1840@1|root,COG1840@2|Bacteria,1Q13Q@1224|Proteobacteria,2TS7Y@28211|Alphaproteobacteria,2JPB9@204441|Rhodospirillales 204441|Rhodospirillales P COG1840 ABC-type Fe3 transport system, periplasmic component - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_6 MMS2_k127_3135730_14 1123229.AUBC01000003_gene2187 2.489e-85 297.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TUS8@28211|Alphaproteobacteria,3K5Z1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E TOBE domain afuC2 - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 MMS2_k127_3135730_12 1305735.JAFT01000005_gene3823 1.225e-102 346.0 COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2TRY8@28211|Alphaproteobacteria,2PFTJ@252301|Oceanicola 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein afuA - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_11,SBP_bac_6,SBP_bac_8 MMS2_k127_3135730_2 1121028.ARQE01000001_gene3212 1.759e-153 503.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2TVQS@28211|Alphaproteobacteria,2PKJK@255475|Aurantimonadaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 MMS2_k127_3135730_10 1123504.JQKD01000029_gene4169 1.166e-108 368.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VN9D@28216|Betaproteobacteria,4AD5C@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 MMS2_k127_3135730_3 1317124.DW2_14445 7.815e-150 501.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TTMX@28211|Alphaproteobacteria 28211|Alphaproteobacteria G ABC-type sugar transport system periplasmic component - - - ko:K02027,ko:K05813 ko02010,map02010 M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 - - SBP_bac_8 MMS2_k127_3135730_17 1410620.SHLA_25c000890 4.01e-59 216.0 COG0395@1|root,COG1175@1|root,COG0395@2|Bacteria,COG1175@2|Bacteria,1MUWS@1224|Proteobacteria,2U3S9@28211|Alphaproteobacteria,4BN6V@82115|Rhizobiaceae 28211|Alphaproteobacteria G Binding-protein-dependent transport system inner membrane component - - - ko:K02026,ko:K05815,ko:K10119 ko02010,map02010 M00196,M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28,3.A.1.1.3 - - BPD_transp_1 MMS2_k127_3135730_7 1123504.JQKD01000029_gene4166 6.191e-113 387.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2VMF7@28216|Betaproteobacteria,4ACH7@80864|Comamonadaceae 28216|Betaproteobacteria P binding-protein-dependent transport systems inner membrane component ycjP_1 - - ko:K02026,ko:K05815 ko02010,map02010 M00198,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3 - - BPD_transp_1 MMS2_k127_3135730_19 1380367.JIBC01000003_gene3962 2.483e-14 76.0 COG1116@1|root,COG1116@2|Bacteria,1MY5D@1224|Proteobacteria,2TQKX@28211|Alphaproteobacteria,3ZX0P@60136|Sulfitobacter 28211|Alphaproteobacteria P ATPases associated with a variety of cellular activities MA20_40215 - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran MMS2_k127_3156523_2 555778.Hneap_1014 4.269e-96 318.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1WXP4@135613|Chromatiales 135613|Chromatiales P ABC transporter znuC - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran MMS2_k127_3156523_0 555778.Hneap_1013 1.425e-122 409.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,1RPYF@1236|Gammaproteobacteria,1WX5H@135613|Chromatiales 135613|Chromatiales P pfam abc-3 - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 MMS2_k127_3156523_3 748280.NH8B_2921 2.086e-76 261.0 COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2VQ1J@28216|Betaproteobacteria,2KQ41@206351|Neisseriales 206351|Neisseriales C NADH dehydrogenase NAD(P)H nitroreductase - - - ko:K09019 ko00240,ko01100,map00240,map01100 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Nitroreductase MMS2_k127_3156523_1 272134.KB731324_gene1027 2.386e-97 323.0 COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin MMS2_k127_3162011_8 519989.ECTPHS_01144 4.554e-98 329.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales 135613|Chromatiales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A MMS2_k127_3162011_7 396588.Tgr7_0194 7.051e-104 350.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales 135613|Chromatiales S PFAM Peptidoglycan-binding lysin domain - - - - - - - - - - - - LysM MMS2_k127_3162011_9 713586.KB900536_gene2230 1.16e-75 258.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase MMS2_k127_3162011_5 765914.ThisiDRAFT_1249 6.586e-112 370.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales 135613|Chromatiales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N MMS2_k127_3162011_4 870187.Thini_2515 1.816e-127 421.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,460GP@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB MMS2_k127_3162011_11 765914.ThisiDRAFT_2493 1.141e-32 135.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 MMS2_k127_3162011_2 713586.KB900536_gene2226 5.913e-209 676.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 MMS2_k127_3162011_6 765912.Thimo_1242 2.337e-106 360.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat MMS2_k127_3162011_0 396588.Tgr7_0201 1.226e-226 708.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N MMS2_k127_3162011_1 396588.Tgr7_0202 5.352e-220 694.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH MMS2_k127_3162011_3 28152.DJ57_3673 4.07e-164 535.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,41D7Z@629|Yersinia 1236|Gammaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iPC815.YPO3762 TrkH MMS2_k127_3162011_10 713586.KB900536_gene2222 8.764e-38 145.0 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria 1236|Gammaproteobacteria H PFAM Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_23,Methyltransf_25,TehB MMS2_k127_3178623_3 1234364.AMSF01000072_gene1791 5.143e-46 167.0 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria,1T2JB@1236|Gammaproteobacteria,1XD89@135614|Xanthomonadales 135614|Xanthomonadales H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 MMS2_k127_3178623_1 1234364.AMSF01000072_gene1790 2.947e-76 266.0 COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1X70A@135614|Xanthomonadales 135614|Xanthomonadales NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_8 MMS2_k127_3178623_0 1234364.AMSF01000072_gene1789 3.115e-99 330.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria,1X73Y@135614|Xanthomonadales 135614|Xanthomonadales S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short MMS2_k127_3178623_2 666685.R2APBS1_2045 7.975e-61 220.0 COG0859@1|root,COG0859@2|Bacteria,1N2DA@1224|Proteobacteria,1SBNA@1236|Gammaproteobacteria,1X65K@135614|Xanthomonadales 135614|Xanthomonadales M PFAM Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 MMS2_k127_3180976_3 460265.Mnod_2123 4.489e-07 54.0 2E09K@1|root,32VX5@2|Bacteria,1N5Z5@1224|Proteobacteria,2UCIG@28211|Alphaproteobacteria,1JVT4@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3180976_1 460265.Mnod_2124 3.13e-87 307.0 COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2U3I3@28211|Alphaproteobacteria,1JTJR@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PFAM PpiC-type peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3 MMS2_k127_3180976_0 1267005.KB911266_gene1224 7.545e-114 373.0 COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2TTDB@28211|Alphaproteobacteria 28211|Alphaproteobacteria C nitrate reductase, gamma subunit narI - 1.7.5.1 ko:K00374 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Nitrate_red_gam MMS2_k127_3180976_2 1411123.JQNH01000001_gene565 6.995e-25 107.0 COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2U19T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Nitrate reductase, delta subunit narJ - - ko:K00373 ko02020,map02020 - - - ko00000,ko00001 - - - Nitrate_red_del MMS2_k127_3200449_0 713587.THITH_01340 4.75e-90 298.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales 135613|Chromatiales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM MMS2_k127_3200449_1 396588.Tgr7_0335 4.589e-87 303.0 COG4775@1|root,COG4775@2|Bacteria,1N5IS@1224|Proteobacteria,1SB24@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Surface antigen - - - - - - - - - - - - Bac_surface_Ag,POTRA MMS2_k127_3200449_2 396588.Tgr7_0332 3.466e-72 250.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 MMS2_k127_3218059_6 1121918.ARWE01000001_gene1358 9.271e-84 289.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42PDA@68525|delta/epsilon subdivisions,2WKF9@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family namA - - - - - - - - - - - Oxidored_FMN MMS2_k127_3218059_14 380749.HY04AAS1_1072 6.09e-20 95.0 COG3370@1|root,COG3370@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - DrsE MMS2_k127_3218059_7 637389.Acaty_c0966 7.143e-83 282.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,2NCSK@225057|Acidithiobacillales 225057|Acidithiobacillales Q Prolyl oligopeptidase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH,Peptidase_S9 MMS2_k127_3218059_8 243159.AFE_2209 1.324e-55 204.0 COG1309@1|root,COG1309@2|Bacteria,1RGCX@1224|Proteobacteria,1S8SN@1236|Gammaproteobacteria,2NCD9@225057|Acidithiobacillales 225057|Acidithiobacillales K Bacterial transcriptional repressor C-terminal - - - - - - - - - - - - TetR_C_13,TetR_N MMS2_k127_3218059_1 1167006.UWK_00991 0.0 1030.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MIPG@213118|Desulfobacterales 28221|Deltaproteobacteria G phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase MMS2_k127_3218059_4 383372.Rcas_0709 4.056e-121 400.0 COG1052@1|root,COG1052@2|Bacteria,2G6NV@200795|Chloroflexi,377YQ@32061|Chloroflexia 32061|Chloroflexia C PFAM D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region - - 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C MMS2_k127_3218059_5 75379.Tint_0878 5.688e-116 383.0 COG1105@1|root,COG1105@2|Bacteria,1MVNW@1224|Proteobacteria,2VNJ4@28216|Betaproteobacteria,1KNRU@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Belongs to the carbohydrate kinase PfkB family - - 2.7.1.11 ko:K16370 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB MMS2_k127_3218059_9 637389.Acaty_c1143 1.979e-55 198.0 COG2044@1|root,COG2044@2|Bacteria,1NX3P@1224|Proteobacteria,1SP0M@1236|Gammaproteobacteria,2ND09@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF-like family - - - ko:K07092 - - - - ko00000 - - - DrsE MMS2_k127_3218059_13 1245469.S58_14080 3.071e-23 108.0 COG2149@1|root,COG2149@2|Bacteria,1N7T3@1224|Proteobacteria,2UG6T@28211|Alphaproteobacteria,3K1GD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF202) - - - ko:K00389 - - - - ko00000 - - - DUF202 MMS2_k127_3218059_12 1123504.JQKD01000032_gene4499 2.794e-24 109.0 COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,4AF2I@80864|Comamonadaceae 28216|Betaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp MMS2_k127_3218059_11 335543.Sfum_0761 1.524e-32 146.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WNBD@28221|Deltaproteobacteria,2MQQ3@213462|Syntrophobacterales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE MMS2_k127_3218059_2 1234364.AMSF01000016_gene1502 2.727e-237 747.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1X523@135614|Xanthomonadales 135614|Xanthomonadales J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL MMS2_k127_3218059_3 75379.Tint_1440 9.717e-133 456.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VHI7@28216|Betaproteobacteria,1KPGP@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox MMS2_k127_3218059_0 75379.Tint_0437 0.0 1439.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHNJ@28216|Betaproteobacteria,1KPH4@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N MMS2_k127_3218059_10 1440774.Y900_006460 8.8e-36 150.0 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,234C9@1762|Mycobacteriaceae 201174|Actinobacteria G the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells manB GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV MMS2_k127_3218059_15 555778.Hneap_0971 2.462e-10 61.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.6 ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase MMS2_k127_3273240_4 1188256.BASI01000002_gene3129 4.152e-09 58.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,3FCND@34008|Rhodovulum 28211|Alphaproteobacteria O C-terminal, D2-small domain, of ClpB protein clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N MMS2_k127_3273240_3 765912.Thimo_2091 9.735e-34 136.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1WZ35@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a MMS2_k127_3273240_1 395493.BegalDRAFT_1894 1.898e-74 259.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,460JY@72273|Thiotrichales 72273|Thiotrichales O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate - 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N MMS2_k127_3273240_0 228410.NE2219 2.671e-80 280.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,371NN@32003|Nitrosomonadales 28216|Betaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans MMS2_k127_3273240_2 1335757.SPICUR_06550 4.414e-42 156.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales 135613|Chromatiales S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like MMS2_k127_327741_3 1123401.JHYQ01000014_gene822 9.325e-116 385.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,461ME@72273|Thiotrichales 72273|Thiotrichales V AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - ABC_tran MMS2_k127_327741_9 329726.AM1_3889 4.811e-35 152.0 COG2329@1|root,COG2329@2|Bacteria,1G7DQ@1117|Cyanobacteria 1117|Cyanobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM MMS2_k127_327741_6 1123368.AUIS01000003_gene1836 7.517e-50 181.0 2F6JJ@1|root,33Z2G@2|Bacteria,1NY2W@1224|Proteobacteria,1SQ7H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_327741_2 75379.Tint_1443 7.038e-130 424.0 COG4106@1|root,COG4106@2|Bacteria,1QVHH@1224|Proteobacteria,2WGRG@28216|Betaproteobacteria,1KP8M@119065|unclassified Burkholderiales 28216|Betaproteobacteria S O-methyltransferase - - - - - - - - - - - - Methyltransf_25 MMS2_k127_327741_0 395494.Galf_1708 3.844e-190 601.0 COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,44VEC@713636|Nitrosomonadales 28216|Betaproteobacteria F Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate purT - 2.1.2.2 ko:K08289 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp,Epimerase MMS2_k127_327741_8 555778.Hneap_1380 1.185e-35 138.0 COG2329@1|root,COG2329@2|Bacteria,1QCV7@1224|Proteobacteria,1SDHZ@1236|Gammaproteobacteria,1WZBS@135613|Chromatiales 135613|Chromatiales C PFAM Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM MMS2_k127_327741_7 1123393.KB891316_gene1611 9.184e-47 177.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,1KSVU@119069|Hydrogenophilales 119069|Hydrogenophilales T Crp-like helix-turn-helix domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding MMS2_k127_327741_10 570967.JMLV01000014_gene2084 2.089e-33 144.0 2C1AX@1|root,33GUX@2|Bacteria,1MZSH@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - MMS2_k127_327741_1 1123393.KB891316_gene1612 1.217e-148 501.0 COG3637@1|root,COG5338@1|root,COG3637@2|Bacteria,COG5338@2|Bacteria,1PFWT@1224|Proteobacteria 1224|Proteobacteria M Protein conserved in bacteria - - - - - - - - - - - - BBP2_2,OMP_b-brl MMS2_k127_327741_4 1234364.AMSF01000095_gene2567 9.853e-72 247.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,1X4S4@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx MMS2_k127_327741_5 765914.ThisiDRAFT_2452 1.621e-53 195.0 COG1073@1|root,COG1073@2|Bacteria,1QUD5@1224|Proteobacteria,1SNT2@1236|Gammaproteobacteria,1X15I@135613|Chromatiales 135613|Chromatiales S Alpha/beta hydrolase family - - - - - - - - - - - - Hydrolase_4 MMS2_k127_3292253_1 1179778.PMM47T1_12938 1.227e-47 174.0 COG5285@1|root,COG5285@2|Bacteria,1NQ4U@1224|Proteobacteria,1RSHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG5285 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - - - - - - - - - - PhyH MMS2_k127_3292253_0 864069.MicloDRAFT_00023760 4.706e-117 384.0 COG1028@1|root,COG1028@2|Bacteria,1MXE0@1224|Proteobacteria,2U1P2@28211|Alphaproteobacteria,1JYZU@119045|Methylobacteriaceae 28211|Alphaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 MMS2_k127_3299234_10 913325.N799_05150 2.517e-115 381.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1X4BE@135614|Xanthomonadales 135614|Xanthomonadales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK MMS2_k127_3299234_0 400668.Mmwyl1_0114 2.693e-231 730.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,1XIX9@135619|Oceanospirillales 135619|Oceanospirillales E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K12368 ko02010,ko02024,ko02030,map02010,map02024,map02030 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS2_k127_3299234_3 1089439.KB902247_gene1035 8.715e-154 492.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,45ZR0@72273|Thiotrichales 72273|Thiotrichales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 MMS2_k127_3299234_7 1238182.C882_2839 2.583e-133 431.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,2JQSG@204441|Rhodospirillales 204441|Rhodospirillales EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K12370 ko02010,map02010 M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N MMS2_k127_3299234_6 1238182.C882_2840 7.958e-140 471.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales 204441|Rhodospirillales EP Belongs to the ABC transporter superfamily dppD - - ko:K02031,ko:K12371 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS2_k127_3299234_5 1238182.C882_2841 5.096e-141 458.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPE7@204441|Rhodospirillales 204441|Rhodospirillales E Oligopeptide/dipeptide transporter, C-terminal region dppF - - ko:K02032,ko:K12372 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS2_k127_3299234_17 396588.Tgr7_2408 8.761e-63 217.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1WYPN@135613|Chromatiales 135613|Chromatiales C Iron--sulfur cluster insertion protein erpA erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn MMS2_k127_3299234_21 870187.Thini_3479 1.245e-39 151.0 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,461BH@72273|Thiotrichales 72273|Thiotrichales M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin MMS2_k127_3299234_25 396588.Tgr7_2410 1.434e-31 136.0 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,1WZS1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_3299234_2 580332.Slit_2455 4.812e-154 495.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,44V0R@713636|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC MMS2_k127_3299234_8 1122603.ATVI01000007_gene1619 1.22e-131 435.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1X4BH@135614|Xanthomonadales 135614|Xanthomonadales P chloride channel clcA - - - - - - - - - - - Voltage_CLC MMS2_k127_3299234_15 261292.Nit79A3_3146 1.45e-91 334.0 COG0463@1|root,COG1807@1|root,COG2246@1|root,COG0463@2|Bacteria,COG1807@2|Bacteria,COG2246@2|Bacteria,1P6JE@1224|Proteobacteria,2VN72@28216|Betaproteobacteria,371MM@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM Glycosyl transferase, family 2 - - 2.4.1.83 ko:K00721,ko:K00786 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA,PMT_2 MMS2_k127_3299234_16 1458275.AZ34_12770 7.981e-76 263.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2VHU3@28216|Betaproteobacteria,4ACS8@80864|Comamonadaceae 28216|Betaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos,Metallophos_2 MMS2_k127_3299234_19 1304275.C41B8_08040 1.594e-47 178.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Pfam SNARE associated Golgi protein VV0785 - - - - - - - - - - - SNARE_assoc MMS2_k127_3299234_14 396588.Tgr7_1321 4.56e-96 323.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,1RPQ9@1236|Gammaproteobacteria,1WXJC@135613|Chromatiales 135613|Chromatiales N PFAM OmpA MotB domain protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA MMS2_k127_3299234_9 765914.ThisiDRAFT_2583 5.81e-116 379.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,1RNTF@1236|Gammaproteobacteria,1WWG9@135613|Chromatiales 135613|Chromatiales N MotA/TolQ/ExbB proton channel family - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB MMS2_k127_3299234_18 1249627.D779_2474 1.074e-62 233.0 COG1639@1|root,COG1639@2|Bacteria,1R50Z@1224|Proteobacteria,1RVKF@1236|Gammaproteobacteria,1WXMG@135613|Chromatiales 135613|Chromatiales T signal transduction protein - - - - - - - - - - - - HDOD MMS2_k127_3299234_27 1515746.HR45_05145 3.295e-23 104.0 COG0818@1|root,COG0818@2|Bacteria,1PYTG@1224|Proteobacteria,1SEER@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Prokaryotic diacylglycerol kinase - - - - - - - - - - - - DAGK_prokar MMS2_k127_3299234_1 1454004.AW11_02130 1.489e-162 538.0 COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,2VTF9@28216|Betaproteobacteria 28216|Betaproteobacteria I SNARE associated Golgi protein yabI_1 - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - LssY_C,PAP2,SNARE_assoc MMS2_k127_3299234_20 118163.Ple7327_2736 1.222e-43 167.0 COG3709@1|root,COG3709@2|Bacteria 2|Bacteria P Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) phnN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006015,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019634,GO:0019637,GO:0019674,GO:0019693,GO:0033863,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046496,GO:0046835,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.23 ko:K05774 ko00030,map00030 - R06836 RC00002 ko00000,ko00001,ko01000 - - iAF1260.b4094,iB21_1397.B21_03926,iBWG_1329.BWG_3809,iECBD_1354.ECBD_3936,iECB_1328.ECB_03966,iECDH10B_1368.ECDH10B_4285,iECDH1ME8569_1439.ECDH1ME8569_3953,iECD_1391.ECD_03966,iEKO11_1354.EKO11_4224,iEcDH1_1363.EcDH1_3897,iEcolC_1368.EcolC_3932,iJO1366.b4094,iSSON_1240.SSON_4270,iUMNK88_1353.UMNK88_4960,iY75_1357.Y75_RS21315 AAA_18,Guanylate_kin MMS2_k127_3299234_24 570967.JMLV01000015_gene3104 1.99e-32 130.0 COG2188@1|root,COG2188@2|Bacteria,1Q856@1224|Proteobacteria,2TSMX@28211|Alphaproteobacteria,2JSA4@204441|Rhodospirillales 204441|Rhodospirillales K UTRA - - - ko:K02043 - - - - ko00000,ko03000 - - - GntR,UTRA MMS2_k127_3299234_28 941449.dsx2_0055 4.75e-18 93.0 COG2188@1|root,COG2188@2|Bacteria,1Q856@1224|Proteobacteria,42X73@68525|delta/epsilon subdivisions,2WYE4@28221|Deltaproteobacteria,2MDED@213115|Desulfovibrionales 28221|Deltaproteobacteria K UTRA domain - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA MMS2_k127_3299234_22 1123072.AUDH01000014_gene1336 2.065e-34 142.0 COG3709@1|root,COG3709@2|Bacteria,1RK3Z@1224|Proteobacteria,2U616@28211|Alphaproteobacteria,2JSXM@204441|Rhodospirillales 204441|Rhodospirillales P Protein of unknown function (DUF1045) - - - - - - - - - - - - DUF1045 MMS2_k127_3299234_4 870187.Thini_0482 3.213e-147 481.0 COG1100@1|root,COG1100@2|Bacteria,1R1W9@1224|Proteobacteria,1SK3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF697) - - - - - - - - - - - - DUF697,MMR_HSR1 MMS2_k127_3299234_11 1123401.JHYQ01000003_gene2117 2.26e-108 368.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 MMS2_k127_3299234_13 555778.Hneap_0784 1.832e-97 340.0 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,1WX21@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA MMS2_k127_3299234_12 555778.Hneap_0785 1.889e-102 338.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1WW9E@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C MMS2_k127_3299234_26 1123519.PSJM300_04035 2.294e-31 130.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1Z0U1@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N MMS2_k127_3299234_23 743299.Acife_2134 2.376e-33 137.0 2E43T@1|root,32Z04@2|Bacteria,1QXMH@1224|Proteobacteria,1T3F6@1236|Gammaproteobacteria,2ND41@225057|Acidithiobacillales 225057|Acidithiobacillales S Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB MMS2_k127_3304189_2 1282362.AEAC466_08065 5.729e-08 62.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,2KGD7@204458|Caulobacterales 204458|Caulobacterales C Belongs to the complex I subunit 6 family - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 MMS2_k127_3304189_1 234267.Acid_5685 7.679e-66 228.0 COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria 57723|Acidobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_7 MMS2_k127_3304189_0 234267.Acid_5691 2.829e-93 315.0 COG1005@1|root,COG1005@2|Bacteria,3Y3XZ@57723|Acidobacteria 57723|Acidobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh MMS2_k127_3338549_0 1318628.MARLIPOL_06564 3.681e-171 551.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,463YH@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim MMS2_k127_3338549_1 519989.ECTPHS_07336 6.311e-154 495.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1WXGA@135613|Chromatiales 135613|Chromatiales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) - - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS2_k127_336360_2 1260251.SPISAL_03905 1.1e-39 150.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,1RN08@1236|Gammaproteobacteria,1X2PA@135613|Chromatiales 135613|Chromatiales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS2_k127_336360_1 187272.Mlg_1085 8.489e-126 409.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RS1R@1236|Gammaproteobacteria,1X291@135613|Chromatiales 135613|Chromatiales EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS2_k127_336360_0 187272.Mlg_1086 2.712e-173 559.0 COG0747@1|root,COG0747@2|Bacteria,1MXB1@1224|Proteobacteria,1SYV2@1236|Gammaproteobacteria,1X2HF@135613|Chromatiales 135613|Chromatiales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS2_k127_3388973_4 1122194.AUHU01000002_gene2664 1.565e-73 250.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,464WQ@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG0412 Dienelactone hydrolase and related enzymes yghX - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH MMS2_k127_3388973_7 653733.Selin_1986 2.909e-37 145.0 COG2608@1|root,COG2608@2|Bacteria 2|Bacteria P mercury ion transmembrane transporter activity - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA MMS2_k127_3388973_1 765913.ThidrDRAFT_2128 9.809e-116 382.0 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria,1WWHR@135613|Chromatiales 135613|Chromatiales I Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 MMS2_k127_3388973_5 1384054.N790_05190 1.887e-63 226.0 COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,1S4YB@1236|Gammaproteobacteria,1X65Q@135614|Xanthomonadales 135614|Xanthomonadales O Glutathione S-transferase gst1 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_N_2,GST_N_3 MMS2_k127_3388973_0 1232683.ADIMK_0771 2.686e-174 553.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RP71@1236|Gammaproteobacteria,46A5J@72275|Alteromonadaceae 1236|Gammaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.90 ko:K00055 ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220 M00537,M00538 R01763,R02611,R04304,R05282,R05347,R05348 RC00087,RC00116 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N MMS2_k127_3388973_6 1158292.JPOE01000005_gene183 1.833e-46 173.0 COG1846@1|root,COG1846@2|Bacteria,1RFUJ@1224|Proteobacteria,2VURD@28216|Betaproteobacteria,1KMAX@119065|unclassified Burkholderiales 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR MMS2_k127_3388973_2 1265502.KB905939_gene2405 5.758e-114 383.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VIYH@28216|Betaproteobacteria,4AAXH@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 MMS2_k127_3388973_3 1158292.JPOE01000005_gene177 4.578e-86 289.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria,1KJUM@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ AMP-binding enzyme fcs - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding MMS2_k127_3400308_2 1121033.AUCF01000006_gene4073 1.014e-92 307.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,2JPVV@204441|Rhodospirillales 204441|Rhodospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core MMS2_k127_3400308_0 1121033.AUCF01000006_gene4074 9.643e-221 713.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JPPB@204441|Rhodospirillales 204441|Rhodospirillales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 MMS2_k127_3400308_1 1121033.AUCF01000006_gene4075 5.662e-93 314.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TRFC@28211|Alphaproteobacteria,2JQTP@204441|Rhodospirillales 204441|Rhodospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core MMS2_k127_3405746_1 1121931.AUHG01000012_gene2634 4.617e-09 62.0 COG0664@1|root,COG0664@2|Bacteria,4NP9Z@976|Bacteroidetes,1I2N5@117743|Flavobacteriia 976|Bacteroidetes K COGs COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding MMS2_k127_3405746_2 666681.M301_1660 0.0008789 47.0 2FJZ4@1|root,34BMG@2|Bacteria,1P0NJ@1224|Proteobacteria,2W405@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3405746_0 243159.AFE_2454 8.735e-18 89.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,2NC6V@225057|Acidithiobacillales 225057|Acidithiobacillales P Na H antiporter - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger MMS2_k127_3406425_9 997296.PB1_00185 6.622e-13 77.0 COG1216@1|root,COG1216@2|Bacteria,1V31A@1239|Firmicutes,4HGKX@91061|Bacilli,1ZPWN@1386|Bacillus 91061|Bacilli S Glycosyltransferase like family - - - - - - - - - - - - Glycos_transf_2 MMS2_k127_3406425_6 1121035.AUCH01000006_gene751 1.584e-73 262.0 COG0438@1|root,COG0438@2|Bacteria,1REGP@1224|Proteobacteria,2W934@28216|Betaproteobacteria,2KZDA@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4 MMS2_k127_3406425_4 1163617.SCD_n02872 1.975e-91 313.0 COG0859@1|root,COG0859@2|Bacteria,1NEWM@1224|Proteobacteria,2VQ5K@28216|Betaproteobacteria 28216|Betaproteobacteria M family 9 - - - - - - - - - - - - Glyco_transf_9 MMS2_k127_3406425_7 1121004.ATVC01000001_gene364 9.125e-30 137.0 2E7CD@1|root,331VK@2|Bacteria,1N8V8@1224|Proteobacteria,2VXUY@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - Wzy_C MMS2_k127_3406425_5 1304883.KI912532_gene1089 2.107e-83 286.0 COG1216@1|root,COG1216@2|Bacteria,1QU2Q@1224|Proteobacteria,2WGZN@28216|Betaproteobacteria,2KUGZ@206389|Rhodocyclales 206389|Rhodocyclales S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 MMS2_k127_3406425_3 1245471.PCA10_52360 3.164e-110 367.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1YCWB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) rfaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107 Glyco_transf_9 MMS2_k127_3406425_2 1049564.TevJSym_bj00090 3.989e-123 408.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1J4K0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0859 ADP-heptose LPS heptosyltransferase rfaF GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iECH74115_1262.ECH74115_4993,iECSP_1301.ECSP_4617,iECs_1301.ECs4498,iG2583_1286.G2583_4359,iZ_1308.Z5047 Glyco_transf_9 MMS2_k127_3406425_8 396588.Tgr7_0466 1.928e-19 91.0 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales 135613|Chromatiales S Zinc-finger domain - - - - - - - - - - - - zf-CHCC MMS2_k127_3406425_1 713586.KB900536_gene1653 5.841e-160 508.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales 135613|Chromatiales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 MMS2_k127_3406425_0 713586.KB900536_gene1654 0.0 1069.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales 135613|Chromatiales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE MMS2_k127_341169_0 614083.AWQR01000024_gene2210 1.532e-57 208.0 COG2207@1|root,COG2207@2|Bacteria,1RCXI@1224|Proteobacteria,2VS7M@28216|Betaproteobacteria,4AE2X@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - Cupin_2,HTH_18 MMS2_k127_341169_3 666685.R2APBS1_0646 1.667e-30 134.0 COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,1T04B@1236|Gammaproteobacteria,1XCYK@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI MMS2_k127_341169_2 1385517.N800_01210 5.728e-52 192.0 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S9N2@1236|Gammaproteobacteria,1XCN3@135614|Xanthomonadales 135614|Xanthomonadales C Cytochrome B561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB MMS2_k127_341169_1 1168067.JAGP01000001_gene2037 5.698e-54 209.0 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,1S5IM@1236|Gammaproteobacteria,462B9@72273|Thiotrichales 72273|Thiotrichales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B MMS2_k127_3434174_1 358220.C380_05095 1.921e-110 365.0 COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4ADC1@80864|Comamonadaceae 28216|Betaproteobacteria T diguanylate cyclase - - - - - - - - - - - - CZB,EAL,GAF_2,GGDEF,PAS_3,PAS_4,Protoglobin MMS2_k127_3434174_2 1123020.AUIE01000009_gene3889 2.564e-87 293.0 COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,1RP6M@1236|Gammaproteobacteria,1YHEN@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008968,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016866,GO:0016868,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.3.1.28 ko:K03271,ko:K12961 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005,ko03036 - - - SIS_2 MMS2_k127_3434174_0 1123393.KB891316_gene2083 1.681e-188 604.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,2WGY2@28216|Betaproteobacteria,1KSKX@119069|Hydrogenophilales 119069|Hydrogenophilales T 7TM diverse intracellular signalling - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF MMS2_k127_3434174_3 314285.KT71_18421 4.212e-81 279.0 COG3491@1|root,COG3491@2|Bacteria,1MUNT@1224|Proteobacteria,1RQ5X@1236|Gammaproteobacteria,1J9TC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the iron ascorbate-dependent oxidoreductase family - - - - - - - - - - - - 2OG-FeII_Oxy,DIOX_N MMS2_k127_3515437_3 1504672.669787460 4.892e-42 162.0 COG3293@1|root,COG3293@2|Bacteria,1RK9T@1224|Proteobacteria,2WFBS@28216|Betaproteobacteria,4AFNZ@80864|Comamonadaceae 1224|Proteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - - MMS2_k127_3515437_1 477228.YO5_05996 8.195e-176 569.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,1SE0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM transposase IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 MMS2_k127_3515437_2 1504672.669787677 1.637e-53 191.0 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2VSH9@28216|Betaproteobacteria,4AHT7@80864|Comamonadaceae 28216|Betaproteobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 MMS2_k127_3515437_4 1121106.JQKB01000072_gene897 1.54e-18 91.0 COG2963@1|root,COG2963@2|Bacteria,1RKI9@1224|Proteobacteria,2UDYB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 MMS2_k127_3515437_0 107635.AZUO01000005_gene4234 8.899e-197 619.0 COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,3710Z@31993|Methylocystaceae 28211|Alphaproteobacteria L Recombinase - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom MMS2_k127_3536239_0 426114.THI_3248 4.269e-269 841.0 COG3511@1|root,COG3511@2|Bacteria,1MVNS@1224|Proteobacteria,2VMDC@28216|Betaproteobacteria,1KK7X@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Phosphoesterase family - - 3.1.4.3 ko:K01114 ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919 - R01312,R02027,R02052,R03332,R07381 RC00017,RC00425 ko00000,ko00001,ko01000,ko02042 - - - Phosphoesterase MMS2_k127_3536239_1 426114.THI_3247 2.425e-184 588.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VMKA@28216|Betaproteobacteria,1KPB6@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C MMS2_k127_3536239_3 1042375.AFPL01000004_gene599 1.12e-174 575.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RQIN@1236|Gammaproteobacteria,464DB@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system dctB - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,dCache_1 MMS2_k127_3536239_2 765910.MARPU_06335 1.639e-178 572.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWTP@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K10126,ko:K10943 ko02020,ko05111,map02020,map05111 M00504,M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat MMS2_k127_3536239_4 572546.Arcpr_1844 2.906e-117 394.0 COG0683@1|root,COG4885@1|root,arCOG01020@2157|Archaea,arCOG04478@2157|Archaea,2XVWV@28890|Euryarchaeota,245XV@183980|Archaeoglobi 183980|Archaeoglobi E Periplasmic binding protein domain - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS2_k127_3536239_5 1254432.SCE1572_20250 1.645e-92 313.0 COG0559@1|root,COG0683@1|root,COG0559@2|Bacteria,COG0683@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2Z0ZI@29|Myxococcales 28221|Deltaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_3536239_7 1254432.SCE1572_20255 1.311e-87 312.0 COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,42TEH@68525|delta/epsilon subdivisions,2WPV9@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_3536239_8 572546.Arcpr_1847 1.899e-86 299.0 COG0411@1|root,arCOG00926@2157|Archaea,2XU0T@28890|Euryarchaeota,245P6@183980|Archaeoglobi 183980|Archaeoglobi E ABC transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS2_k127_3536239_6 1254432.SCE1572_20265 3.452e-89 306.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2YV0S@29|Myxococcales 28221|Deltaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS2_k127_3546117_0 765911.Thivi_0065 1.924e-84 292.0 COG2199@1|root,COG5000@1|root,COG3706@2|Bacteria,COG5000@2|Bacteria,1MX83@1224|Proteobacteria,1RMRP@1236|Gammaproteobacteria,1X2J7@135613|Chromatiales 135613|Chromatiales T diguanylate cyclase - - - - - - - - - - - - GGDEF MMS2_k127_3546117_2 1226994.AMZB01000126_gene3993 1.799e-29 121.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T1I4@1236|Gammaproteobacteria,1YERR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. cyaA - - - - - - - - - - - GAF,GGDEF MMS2_k127_3546117_1 243159.AFE_3275 6.656e-84 295.0 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,2NC53@225057|Acidithiobacillales 225057|Acidithiobacillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA MMS2_k127_3570432_0 1126627.BAWE01000004_gene3988 7.061e-119 404.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,3JTXA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding MMS2_k127_3570432_1 402626.Rpic_0467 1.349e-52 202.0 COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,2VKZD@28216|Betaproteobacteria,1K71P@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Exonuclease, RNase T and DNA polymerase III - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T MMS2_k127_3571530_4 765914.ThisiDRAFT_2168 1.638e-76 265.0 COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,1RZYE@1236|Gammaproteobacteria,1WW9B@135613|Chromatiales 135613|Chromatiales S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 MMS2_k127_3571530_7 396588.Tgr7_2737 1.307e-43 175.0 COG0607@1|root,COG0607@2|Bacteria,1RKAQ@1224|Proteobacteria,1SC2Q@1236|Gammaproteobacteria,1X1H4@135613|Chromatiales 135613|Chromatiales P Rhodanese-like domain - - - - - - - - - - - - Rhodanese MMS2_k127_3571530_3 396588.Tgr7_2738 2.119e-112 368.0 COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,1RNZ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B MMS2_k127_3571530_0 396588.Tgr7_2744 1.108e-280 879.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH MMS2_k127_3571530_8 1218084.BBJK01000068_gene4978 0.000241 51.0 2ENRC@1|root,33GCJ@2|Bacteria,1NH0I@1224|Proteobacteria,2W5AS@28216|Betaproteobacteria,1KB00@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2591) - - - - - - - - - - - - DUF2591 MMS2_k127_3571530_6 1038869.AXAN01000006_gene960 2.192e-48 196.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2VSIU@28216|Betaproteobacteria,1K4TW@119060|Burkholderiaceae 28216|Betaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE MMS2_k127_3571530_1 519989.ECTPHS_02601 2.745e-157 511.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales 135613|Chromatiales J SAM-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM MMS2_k127_3571530_2 555778.Hneap_0902 5.64e-122 395.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales 135613|Chromatiales M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT MMS2_k127_3571530_5 1123393.KB891316_gene1344 1.49e-68 240.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,1KRFY@119069|Hydrogenophilales 119069|Hydrogenophilales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt MMS2_k127_3573516_4 338963.Pcar_1751 0.0004167 46.0 COG4963@1|root,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria,43SJ6@69541|Desulfuromonadales 28221|Deltaproteobacteria D Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,CBP_BcsQ,Response_reg MMS2_k127_3573516_0 234267.Acid_4160 3.206e-170 544.0 COG4962@1|root,COG4962@2|Bacteria,3Y360@57723|Acidobacteria 57723|Acidobacteria U PFAM type II secretion system protein E - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE MMS2_k127_3573516_1 240015.ACP_1109 3.538e-58 214.0 COG4965@1|root,COG4965@2|Bacteria,3Y4RR@57723|Acidobacteria,2JJ91@204432|Acidobacteriia 204432|Acidobacteriia U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF MMS2_k127_3573516_2 1340493.JNIF01000003_gene3299 1.833e-57 211.0 COG2064@1|root,COG2064@2|Bacteria,3Y4FI@57723|Acidobacteria 57723|Acidobacteria NU type II secretion system - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF MMS2_k127_3573516_3 1267535.KB906767_gene1384 2.69e-22 102.0 COG1430@1|root,COG1430@2|Bacteria 2|Bacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 MMS2_k127_3587031_1 75379.Tint_3047 2.172e-75 260.0 COG0845@1|root,COG0845@2|Bacteria,1REPS@1224|Proteobacteria 1224|Proteobacteria M Efflux transporter, RND family, MFP subunit - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 MMS2_k127_3587031_0 75379.Tint_3048 0.0 1092.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran MMS2_k127_3597778_2 519989.ECTPHS_00060 2.725e-149 477.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N MMS2_k127_3597778_11 1123401.JHYQ01000037_gene1617 9.488e-28 124.0 COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S395@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF2189 MMS2_k127_3597778_6 1249627.D779_1501 1.855e-73 256.0 COG0242@1|root,COG0242@2|Bacteria,1QM3A@1224|Proteobacteria,1RZHN@1236|Gammaproteobacteria,1WX64@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase MMS2_k127_3597778_9 765912.Thimo_2184 5.513e-57 203.0 COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,1S2A4@1236|Gammaproteobacteria,1WXZM@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 MMS2_k127_3597778_5 572477.Alvin_0796 8.33e-89 301.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1WX0I@135613|Chromatiales 135613|Chromatiales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 MMS2_k127_3597778_4 396588.Tgr7_0815 6.054e-125 407.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1WWBW@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 MMS2_k127_3597778_8 765914.ThisiDRAFT_0033 4.075e-66 237.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1WX6S@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO MMS2_k127_3597778_7 396588.Tgr7_0813 1.1e-67 235.0 COG0778@1|root,COG0778@2|Bacteria,1NMNU@1224|Proteobacteria 1224|Proteobacteria C Putative TM nitroreductase - - - - - - - - - - - - Nitroreductase MMS2_k127_3597778_10 1517416.IDAT_12655 2.361e-53 193.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,2QG2A@267893|Idiomarinaceae 1236|Gammaproteobacteria K Belongs to the P(II) protein family glnB GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006808,GO:0008144,GO:0008150,GO:0009889,GO:0010565,GO:0017076,GO:0019216,GO:0019217,GO:0019222,GO:0030234,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042304,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0046890,GO:0050789,GO:0050790,GO:0050794,GO:0062012,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:0097367,GO:0098772,GO:1901265,GO:1901363 - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II MMS2_k127_3597778_0 396588.Tgr7_0811 1.463e-216 683.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase MMS2_k127_3597778_3 1122603.ATVI01000009_gene2574 2.197e-145 465.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1X36R@135614|Xanthomonadales 135614|Xanthomonadales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA MMS2_k127_3597778_1 519989.ECTPHS_01989 1.882e-166 531.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1WW90@135613|Chromatiales 135613|Chromatiales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA MMS2_k127_3597778_13 395494.Galf_0368 1.255e-09 63.0 2EHK0@1|root,33BBV@2|Bacteria,1NGIK@1224|Proteobacteria,2VXN8@28216|Betaproteobacteria,44W3C@713636|Nitrosomonadales 28216|Betaproteobacteria - - - - - ko:K06950 - - - - ko00000 - - - - MMS2_k127_3597778_12 713586.KB900536_gene1353 7.92e-25 110.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 MMS2_k127_360610_0 631454.N177_0056 4.952e-59 206.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,1JNAT@119043|Rhodobiaceae 28211|Alphaproteobacteria P E1-E2 ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase MMS2_k127_360610_1 416348.Hlac_3039 2.374e-51 187.0 arCOG13007@1|root,arCOG13007@2157|Archaea,2XXWB@28890|Euryarchaeota,23WKQ@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - MMS2_k127_360610_2 604331.AUHY01000069_gene2256 4.942e-36 141.0 COG3019@1|root,COG3019@2|Bacteria 2|Bacteria S metal-binding protein - - - - - - - - - - - - DUF411 MMS2_k127_3609542_3 396588.Tgr7_2890 1.87e-147 471.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C MMS2_k127_3609542_1 396588.Tgr7_2889 3.417e-210 655.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase MMS2_k127_3609542_8 765913.ThidrDRAFT_1995 6.325e-22 100.0 2DQ0J@1|root,3348C@2|Bacteria,1NBQ2@1224|Proteobacteria,1SPMC@1236|Gammaproteobacteria,1X1A6@135613|Chromatiales 135613|Chromatiales S Chemoreceptor zinc-binding domain - - - - - - - - - - - - CZB MMS2_k127_3609542_5 519989.ECTPHS_03804 5.589e-137 451.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales 135613|Chromatiales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt MMS2_k127_3609542_4 869210.Marky_0296 1.614e-137 447.0 COG4663@1|root,COG4663@2|Bacteria,1WJ6R@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal MMS2_k127_3609542_7 396588.Tgr7_2885 4.187e-72 246.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1WY0E@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC MMS2_k127_3609542_2 519989.ECTPHS_03794 9.971e-161 522.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1WVW3@135613|Chromatiales 135613|Chromatiales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp MMS2_k127_3609542_6 2340.JV46_22820 1.026e-111 368.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,1J60A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain rbcR - - ko:K21703,ko:K21711 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate MMS2_k127_3609542_0 870187.Thini_1183 2.148e-307 944.0 COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,4604Y@72273|Thiotrichales 72273|Thiotrichales G RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site cbbL - 4.1.1.39 ko:K01601 ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200 M00165,M00166,M00532 R00024,R03140 RC00172,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N MMS2_k127_3621426_7 1335757.SPICUR_07625 2.208e-65 229.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales 135613|Chromatiales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C MMS2_k127_3621426_5 1485544.JQKP01000002_gene1623 3.978e-109 368.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,44V42@713636|Nitrosomonadales 28216|Betaproteobacteria M D-ala D-ala ligase N-terminus ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N MMS2_k127_3621426_8 472759.Nhal_0494 4.675e-52 194.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1X2GI@135613|Chromatiales 135613|Chromatiales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 MMS2_k127_3621426_1 519989.ECTPHS_01899 2.228e-218 687.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA MMS2_k127_3621426_2 396588.Tgr7_0775 4.283e-175 557.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales 135613|Chromatiales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin MMS2_k127_3621426_3 396588.Tgr7_0776 6.302e-153 487.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1WW5R@135613|Chromatiales 135613|Chromatiales M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC MMS2_k127_3621426_10 713586.KB900536_gene1365 2.174e-13 75.0 COG4701@1|root,COG4701@2|Bacteria 2|Bacteria S Protein of unknown function (DUF721) Y3619 - - - - - - - - - - - DUF721 MMS2_k127_3621426_6 519989.ECTPHS_01919 1.065e-79 275.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1WWMP@135613|Chromatiales 135613|Chromatiales M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 MMS2_k127_3621426_0 1286106.MPL1_05679 0.0 1260.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,45ZWT@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW MMS2_k127_3621426_4 1397528.Q671_16000 5.135e-137 447.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1XHHB@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ MMS2_k127_3621426_9 498211.CJA_2917 2.114e-24 106.0 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1FFVK@10|Cellvibrio 1236|Gammaproteobacteria HL Thiamine monophosphate synthase mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 NUDIX,NUDIX_4,TMP-TENI MMS2_k127_3637197_10 390235.PputW619_4797 7.455e-63 234.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1YV7A@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Aminoglycoside phosphotransferase - GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH MMS2_k127_3637197_3 765911.Thivi_0735 2.319e-116 387.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC MMS2_k127_3637197_8 935567.JAES01000023_gene2498 7.325e-70 246.0 COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,1RQ7V@1236|Gammaproteobacteria,1X44X@135614|Xanthomonadales 135614|Xanthomonadales S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 MMS2_k127_3637197_4 1168067.JAGP01000001_gene436 9.981e-105 365.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,1RPPS@1236|Gammaproteobacteria,46100@72273|Thiotrichales 72273|Thiotrichales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 MMS2_k127_3637197_7 519989.ECTPHS_04134 4.977e-82 282.0 COG0392@1|root,COG0392@2|Bacteria,1R5YC@1224|Proteobacteria,1S815@1236|Gammaproteobacteria,1WX3Y@135613|Chromatiales 135613|Chromatiales S Lysylphosphatidylglycerol synthase TM region - - - - - - - - - - - - LPG_synthase_TM MMS2_k127_3637197_19 84531.JMTZ01000053_gene1534 1.083e-05 51.0 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1SGAM@1236|Gammaproteobacteria,1X8VN@135614|Xanthomonadales 135614|Xanthomonadales S SlyX slyX - - ko:K03745 - - - - ko00000 - - - SlyX MMS2_k127_3637197_17 396588.Tgr7_3049 6.905e-14 81.0 COG5481@1|root,COG5481@2|Bacteria 2|Bacteria S small protein containing a coiled-coil domain MA20_03740 - - - - - - - - - - - DUF465 MMS2_k127_3637197_6 1121406.JAEX01000005_gene2875 1.124e-86 324.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2M9J5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0547 Asp_Glu_race MMS2_k127_3637197_0 870187.Thini_0921 1.074e-256 808.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,4603G@72273|Thiotrichales 72273|Thiotrichales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C MMS2_k127_3637197_1 765914.ThisiDRAFT_0180 1.085e-232 730.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C MMS2_k127_3637197_16 1158762.KB898041_gene1238 1.322e-18 96.0 298KX@1|root,2ZVRP@2|Bacteria,1P89W@1224|Proteobacteria,1SUU7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3637197_5 396588.Tgr7_2771 6.033e-95 325.0 COG0625@1|root,COG0625@2|Bacteria 2|Bacteria O glutathione transferase activity ligE - 2.5.1.18 ko:K00799,ko:K03675 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000,ko03110 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 MMS2_k127_3637197_9 396588.Tgr7_2770 1.281e-67 236.0 COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,1S68X@1236|Gammaproteobacteria,1WXZT@135613|Chromatiales 135613|Chromatiales S EVE domain - - - - - - - - - - - - EVE MMS2_k127_3637197_12 205922.Pfl01_5438 5.682e-42 162.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1YN50@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family ygfA GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298 5-FTHF_cyc-lig MMS2_k127_3637197_15 765911.Thivi_3388 1.395e-21 101.0 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA MMS2_k127_3637197_18 472759.Nhal_3714 1.971e-06 57.0 2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SX58@1236|Gammaproteobacteria,1WZBH@135613|Chromatiales 135613|Chromatiales S TIGRFAM TIGR02449 family protein - - - ko:K09892 - - - - ko00000,ko03036 - - - - MMS2_k127_3637197_13 1158150.KB906248_gene2267 3.22e-34 134.0 2CFFZ@1|root,34BFH@2|Bacteria,1P1YF@1224|Proteobacteria,1SRW1@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3637197_14 713586.KB900536_gene2595 3.459e-30 130.0 COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0149 family - - - ko:K09895 - - - - ko00000 - - - UPF0149 MMS2_k127_3637197_2 396588.Tgr7_2764 1.439e-206 650.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 MMS2_k127_3637197_11 396588.Tgr7_2763 1.419e-47 177.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales 135613|Chromatiales CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 MMS2_k127_3638548_22 1225184.ALXE01000023_gene1853 8.089e-50 179.0 COG1522@1|root,COG1522@2|Bacteria,1QW36@1224|Proteobacteria,1S2P5@1236|Gammaproteobacteria,3VYGE@53335|Pantoea 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type MMS2_k127_3638548_14 78398.KS43_08470 1.79e-94 314.0 COG1284@1|root,COG1284@2|Bacteria,1RDIV@1224|Proteobacteria,1RSIN@1236|Gammaproteobacteria,1MQK6@122277|Pectobacterium 1236|Gammaproteobacteria S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - YitT_membrane MMS2_k127_3638548_4 1441930.Z042_09525 2.806e-184 592.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,3ZZJG@613|Serratia 1236|Gammaproteobacteria E Catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iJN746.PP_3590 Aminotran_1_2 MMS2_k127_3638548_19 29581.BW37_02458 9.331e-61 214.0 COG0431@1|root,COG0431@2|Bacteria,1N305@1224|Proteobacteria,2VTD8@28216|Betaproteobacteria,477C1@75682|Oxalobacteraceae 28216|Betaproteobacteria C NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red MMS2_k127_3638548_18 555778.Hneap_1517 1.422e-63 224.0 COG0454@1|root,COG0456@2|Bacteria,1RKJA@1224|Proteobacteria,1T1ZP@1236|Gammaproteobacteria,1X1TJ@135613|Chromatiales 135613|Chromatiales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 MMS2_k127_3638548_17 330214.NIDE3617 1.504e-66 231.0 COG3545@1|root,COG3545@2|Bacteria 2|Bacteria S Serine hydrolase - - 1.3.1.75 ko:K07002,ko:K19073 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06272,R06896 RC01376 ko00000,ko00001,ko01000 - - - Ser_hydrolase MMS2_k127_3638548_23 887062.HGR_06136 4.494e-46 169.0 COG3450@1|root,COG3450@2|Bacteria,1N0F7@1224|Proteobacteria,2VU3R@28216|Betaproteobacteria 28216|Betaproteobacteria S enzyme of the cupin superfamily - - - ko:K06995 - - - - ko00000 - - - Cupin_3 MMS2_k127_3638548_15 358220.C380_00200 2.144e-80 271.0 COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2VQN8@28216|Betaproteobacteria,4AE1T@80864|Comamonadaceae 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA MMS2_k127_3638548_0 1123257.AUFV01000008_gene644 5.337e-221 699.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X55C@135614|Xanthomonadales 135614|Xanthomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_4,sCache_3_2 MMS2_k127_3638548_27 1116369.KB890024_gene2909 2.296e-38 156.0 COG0451@1|root,COG0451@2|Bacteria,1MWYB@1224|Proteobacteria,2TSDE@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10 MMS2_k127_3638548_3 1492922.GY26_19945 1.254e-202 633.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RRPI@1236|Gammaproteobacteria 1236|Gammaproteobacteria CE Tartrate dehydrogenase dmlA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0006082,GO:0006108,GO:0008150,GO:0008152,GO:0009027,GO:0009987,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019752,GO:0036094,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046553,GO:0046872,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 - R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_1288 Iso_dh MMS2_k127_3638548_6 1166948.JPZL01000002_gene1413 1.074e-157 501.0 COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,1RP4M@1236|Gammaproteobacteria,1XNFN@135619|Oceanospirillales 135619|Oceanospirillales S Alpha/beta hydrolase family - - 3.8.1.3 ko:K01561 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - Abhydrolase_1 MMS2_k127_3638548_9 290398.Csal_2774 2.625e-130 422.0 COG0583@1|root,COG0583@2|Bacteria,1MVJ7@1224|Proteobacteria,1RMNJ@1236|Gammaproteobacteria,1XP47@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_3638548_13 614083.AWQR01000024_gene2209 8.549e-103 348.0 COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,2VMH0@28216|Betaproteobacteria,4AAMY@80864|Comamonadaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_3638548_16 314345.SPV1_10436 2.612e-75 264.0 COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria 1224|Proteobacteria GM Nad-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase,NAD_binding_10 MMS2_k127_3638548_12 314345.SPV1_10441 5.508e-104 346.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_3638548_20 543728.Vapar_2682 3.365e-54 198.0 COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria,2VM9F@28216|Betaproteobacteria,4ADEU@80864|Comamonadaceae 28216|Betaproteobacteria H ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran MMS2_k127_3638548_21 1101195.Meth11DRAFT_0459 9.327e-54 191.0 COG2824@1|root,COG2824@2|Bacteria,1RGUU@1224|Proteobacteria,2VSKS@28216|Betaproteobacteria,2KMVC@206350|Nitrosomonadales 206350|Nitrosomonadales P PhnA Zinc-Ribbon - - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon MMS2_k127_3638548_8 1123392.AQWL01000001_gene1481 2.798e-147 472.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2W90N@28216|Betaproteobacteria,1KRZ3@119069|Hydrogenophilales 119069|Hydrogenophilales T PAS fold - - - - - - - - - - - - GGDEF,PAS_3 MMS2_k127_3638548_1 1123393.KB891316_gene1603 1.399e-213 679.0 COG0119@1|root,COG0119@2|Bacteria,1NXD6@1224|Proteobacteria 1224|Proteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) - - - - - - - - - - - - - MMS2_k127_3638548_30 395019.Bmul_0107 8.963e-21 103.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,1K6XM@119060|Burkholderiaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N MMS2_k127_3638548_29 1163617.SCD_n02273 7.89e-28 124.0 COG1102@1|root,COG1102@2|Bacteria,1RGPZ@1224|Proteobacteria 1224|Proteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 MMS2_k127_3638548_2 765914.ThisiDRAFT_2246 3.894e-207 659.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 MMS2_k127_3638548_10 1417296.U879_00920 6.487e-109 367.0 COG2132@1|root,COG2132@2|Bacteria,1NXIG@1224|Proteobacteria 1224|Proteobacteria Q Multicopper oxidase - - - - - - - - - - - - - MMS2_k127_3638548_7 1430440.MGMSRv2_1069 2.3e-151 499.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,2U4XR@28211|Alphaproteobacteria,2JW9H@204441|Rhodospirillales 204441|Rhodospirillales C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - 1.2.7.1 ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C MMS2_k127_3638548_5 713587.THITH_06955 3.74e-165 528.0 COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1WXJB@135613|Chromatiales 135613|Chromatiales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C MMS2_k127_3638548_26 1162668.LFE_0044 2.289e-41 162.0 COG1014@1|root,COG1014@2|Bacteria,3J0TG@40117|Nitrospirae 40117|Nitrospirae C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR MMS2_k127_3638548_11 1111732.AZOD01000014_gene1458 2.455e-108 363.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1X48X@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK MMS2_k127_3638548_25 743299.Acife_2273 5.748e-43 166.0 COG1416@1|root,COG1416@2|Bacteria,1N0U1@1224|Proteobacteria,1SGKY@1236|Gammaproteobacteria,2NCV2@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE MMS2_k127_3638548_24 637390.AFOH01000110_gene2868 1.016e-43 165.0 COG1416@1|root,COG1416@2|Bacteria,1RBQX@1224|Proteobacteria,1SDBN@1236|Gammaproteobacteria,2NDS4@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF-like family - - - - - - - - - - - - DrsE MMS2_k127_3638548_28 75379.Tint_0706 7.752e-29 125.0 COG1651@1|root,COG1651@2|Bacteria,1NEFD@1224|Proteobacteria,2VKFR@28216|Betaproteobacteria 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbG - - ko:K03805 - - - - ko00000,ko03110 - - - Thioredoxin_2 MMS2_k127_3644377_0 519989.ECTPHS_07331 0.0 1169.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr MMS2_k127_3644377_1 396588.Tgr7_0080 0.0 1091.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C MMS2_k127_3644377_2 426114.THI_0673 7.633e-132 426.0 COG3448@1|root,COG4175@1|root,COG3448@2|Bacteria,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2VJMH@28216|Betaproteobacteria,1KPG9@119065|unclassified Burkholderiales 28216|Betaproteobacteria E ATPases associated with a variety of cellular activities - - 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran MMS2_k127_3644887_13 396588.Tgr7_2031 4.769e-81 275.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,1RR06@1236|Gammaproteobacteria,1WVZF@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13641 - - - - ko00000,ko03000 - - - HTH_IclR,IclR MMS2_k127_3644887_1 396588.Tgr7_2034 0.0 1198.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RYC8@1236|Gammaproteobacteria,1WX4W@135613|Chromatiales 135613|Chromatiales G Transketolase central region - - - - - - - - - - - - XFP,XFP_N MMS2_k127_3644887_4 396588.Tgr7_2035 2.099e-199 631.0 COG3395@1|root,COG3395@2|Bacteria,1QKU1@1224|Proteobacteria,1TIZB@1236|Gammaproteobacteria,1WXF7@135613|Chromatiales 135613|Chromatiales S Type III effector Hrp-dependent - - - - - - - - - - - - DUF1357_C,DUF1537 MMS2_k127_3644887_2 349163.Acry_2384 2.348e-276 854.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2JR59@204441|Rhodospirillales 204441|Rhodospirillales F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate - GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N MMS2_k127_3644887_17 519989.ECTPHS_03011 1.224e-40 155.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1WYQV@135613|Chromatiales 135613|Chromatiales J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS MMS2_k127_3644887_14 396588.Tgr7_2275 4.531e-66 249.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like MMS2_k127_3644887_5 396588.Tgr7_2276 2.442e-199 631.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1WWUV@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh MMS2_k127_3644887_11 396588.Tgr7_2277 1.1e-104 350.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1WWRB@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta MMS2_k127_3644887_19 519989.ECTPHS_03031 1.789e-23 118.0 COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,1WY80@135613|Chromatiales 135613|Chromatiales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE MMS2_k127_3644887_0 748247.AZKH_1274 0.0 1253.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,2KV8K@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 MMS2_k127_3644887_20 1247649.D560_1985 4.458e-16 84.0 COG3133@1|root,COG3133@2|Bacteria,1RA1D@1224|Proteobacteria,2VVGJ@28216|Betaproteobacteria,3T3TY@506|Alcaligenaceae 28216|Betaproteobacteria M Outer membrane lipoprotein slyB - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti MMS2_k127_3644887_15 519989.ECTPHS_03041 4.187e-48 177.0 COG2888@1|root,COG2888@2|Bacteria,1P9T7@1224|Proteobacteria,1RYIB@1236|Gammaproteobacteria,1WW9G@135613|Chromatiales 135613|Chromatiales J Zinc-ribbon containing domain - - - - - - - - - - - - DUF1451 MMS2_k127_3644887_6 690850.Desaf_1382 2.192e-182 581.0 COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2M8IG@213115|Desulfovibrionales 28221|Deltaproteobacteria M TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase MMS2_k127_3644887_8 713586.KB900536_gene1135 1.15e-131 439.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase MMS2_k127_3644887_10 396588.Tgr7_2289 1.66e-108 358.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales 135613|Chromatiales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC MMS2_k127_3644887_16 1218086.BBNB01000002_gene2748 5.54e-44 166.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,3WXBC@544|Citrobacter 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 MMS2_k127_3644887_7 396588.Tgr7_2291 9.543e-142 458.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales 135613|Chromatiales T PFAM PhoH family protein - - - ko:K06217 - - - - ko00000 - - - PhoH MMS2_k127_3644887_3 396588.Tgr7_2292 4.296e-235 733.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 MMS2_k127_3644887_18 243159.AFE_0408 5.787e-24 106.0 2ADNV@1|root,313DS@2|Bacteria,1QCY9@1224|Proteobacteria,1T8S9@1236|Gammaproteobacteria,2NDC5@225057|Acidithiobacillales 225057|Acidithiobacillales S Protein of unknown function (DUF2892) - - - - - - - - - - - - DUF2892 MMS2_k127_3644887_12 1417296.U879_20590 1.034e-93 311.0 COG1584@1|root,COG1584@2|Bacteria,1N3HP@1224|Proteobacteria,2U670@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GPR1/FUN34/yaaH family - - - ko:K07034 - - - - ko00000 - - - Grp1_Fun34_YaaH MMS2_k127_3644887_9 243231.GSU2350 5.122e-117 386.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans MMS2_k127_365985_1 519989.ECTPHS_03222 3.429e-134 431.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1WWGC@135613|Chromatiales 135613|Chromatiales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt MMS2_k127_365985_0 396588.Tgr7_1832 1.202e-143 467.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WW5M@135613|Chromatiales 135613|Chromatiales EH Anthranilate synthase component I - - 2.6.1.85,4.1.3.27 ko:K01657,ko:K01665 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind MMS2_k127_365985_4 519989.ECTPHS_03227 1.751e-66 239.0 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 MMS2_k127_365985_2 1049564.TevJSym_bc00190 5.939e-98 331.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1J56S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - ko:K07082 - - - - ko00000 - - - YceG MMS2_k127_365985_3 290398.Csal_1606 5.902e-68 241.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XJCZ@135619|Oceanospirillales 135619|Oceanospirillales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin MMS2_k127_365985_5 1122201.AUAZ01000017_gene2914 1.431e-60 223.0 COG0470@1|root,COG0470@2|Bacteria,1R9U1@1224|Proteobacteria,1T1C8@1236|Gammaproteobacteria,46D20@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III, delta subunit holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C MMS2_k127_365985_6 396588.Tgr7_1827 1.107e-46 172.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1WYAQ@135613|Chromatiales 135613|Chromatiales NU PFAM Type IV pilus assembly PilZ - - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ MMS2_k127_3671037_2 1234364.AMSF01000033_gene338 2.482e-46 175.0 2EJ60@1|root,337WG@2|Bacteria,1N9QH@1224|Proteobacteria,1T8TU@1236|Gammaproteobacteria,1X80G@135614|Xanthomonadales 135614|Xanthomonadales S Atypical PilZ domain, cyclic di-GMP receptor - - - - - - - - - - - - PilZ_2 MMS2_k127_3671037_0 666685.R2APBS1_2999 2.721e-222 698.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1X3YG@135614|Xanthomonadales 135614|Xanthomonadales T Fis family transcriptional regulator fleQ - - ko:K10941 ko02020,ko02025,ko05111,map02020,map02025,map05111 - - - ko00000,ko00001,ko03000 - - - FleQ,HTH_8,Sigma54_activat MMS2_k127_3671037_3 1234364.AMSF01000033_gene336 6.11e-42 156.0 COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,1SD52@1236|Gammaproteobacteria,1X7II@135614|Xanthomonadales 135614|Xanthomonadales N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE MMS2_k127_3671037_1 1234364.AMSF01000033_gene335 2.928e-63 220.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,1X4M2@135614|Xanthomonadales 135614|Xanthomonadales N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C MMS2_k127_368188_3 637390.AFOH01000013_gene704 6.448e-71 249.0 290SD@1|root,2ZNEH@2|Bacteria,1P6XW@1224|Proteobacteria,1STK8@1236|Gammaproteobacteria,2NC0Z@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_368188_0 555778.Hneap_1764 7.863e-165 530.0 29IGX@1|root,32MKS@2|Bacteria,1RKR3@1224|Proteobacteria,1S8A0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_368188_2 713586.KB900536_gene1907 1.946e-105 351.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales 135613|Chromatiales H Belongs to the ribF family - - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase MMS2_k127_368188_1 472759.Nhal_0903 7.641e-132 425.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1WXI8@135613|Chromatiales 135613|Chromatiales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS MMS2_k127_3694352_1 519989.ECTPHS_01399 1.454e-139 445.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1WWUE@135613|Chromatiales 135613|Chromatiales J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e MMS2_k127_3694352_0 713586.KB900536_gene2049 1.488e-269 847.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f MMS2_k127_3694352_4 93220.LV28_10905 6.864e-75 258.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria,1K16M@119060|Burkholderiaceae 28216|Betaproteobacteria E D,D-heptose 1,7-bisphosphate phosphatase gmhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase,Hydrolase_like,PNK3P MMS2_k127_3694352_3 754477.Q7C_2194 4.996e-75 269.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,460NX@72273|Thiotrichales 72273|Thiotrichales I Acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase MMS2_k127_3694352_5 396588.Tgr7_3252 4.791e-70 256.0 2F2KZ@1|root,33VHM@2|Bacteria,1NV1E@1224|Proteobacteria,1SN95@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3694352_2 765910.MARPU_14020 1.428e-135 439.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WXQZ@135613|Chromatiales 135613|Chromatiales L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C MMS2_k127_3710140_5 637389.Acaty_c0465 7.983e-119 395.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,2NC6V@225057|Acidithiobacillales 225057|Acidithiobacillales P Na H antiporter - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger MMS2_k127_3710140_0 426114.THI_0525 1.113e-230 720.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,1KIVQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno2 - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N MMS2_k127_3710140_2 743299.Acife_0794 1.013e-150 491.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,2NCMW@225057|Acidithiobacillales 225057|Acidithiobacillales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C MMS2_k127_3710140_3 75379.Tint_0447 3.877e-129 419.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,2VPZ0@28216|Betaproteobacteria 28216|Betaproteobacteria G deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC MMS2_k127_3710140_1 637390.AFOH01000047_gene2002 3.049e-194 618.0 COG1249@1|root,COG1249@2|Bacteria,1QXM8@1224|Proteobacteria,1T3ES@1236|Gammaproteobacteria,2NC9M@225057|Acidithiobacillales 225057|Acidithiobacillales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim MMS2_k127_3710140_4 555778.Hneap_0779 8.669e-128 422.0 COG3174@1|root,COG3174@2|Bacteria,1RA19@1224|Proteobacteria,1S78D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010 MMS2_k127_3710140_6 1123504.JQKD01000032_gene4499 2.735e-21 102.0 COG0589@1|root,COG0589@2|Bacteria,1N02E@1224|Proteobacteria,2VU60@28216|Betaproteobacteria,4AF2I@80864|Comamonadaceae 28216|Betaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp MMS2_k127_3710140_8 1163617.SCD_n01946 0.0001105 50.0 2ENVQ@1|root,33GGS@2|Bacteria,1NGVT@1224|Proteobacteria,2VY6X@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2934) - - - - - - - - - - - - DUF2934 MMS2_k127_3710140_7 1121351.AUAP01000001_gene823 1.142e-05 55.0 COG3471@1|root,COG3471@2|Bacteria,1RKQM@1224|Proteobacteria,2VSYF@28216|Betaproteobacteria,2KRCK@206351|Neisseriales 206351|Neisseriales S Protein of unknown function (DUF541) - - - - - - - - - - - - SIMPL MMS2_k127_3733258_4 1500890.JQNL01000001_gene1725 2.73e-13 70.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1X6GG@135614|Xanthomonadales 135614|Xanthomonadales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC MMS2_k127_3733258_1 765910.MARPU_15790 7.804e-147 471.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales 135613|Chromatiales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas MMS2_k127_3733258_0 396588.Tgr7_0118 8.996e-153 504.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD MMS2_k127_3733258_2 187272.Mlg_2825 1.394e-86 309.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1WW5V@135613|Chromatiales 135613|Chromatiales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N MMS2_k127_3733258_3 472175.EL18_01341 1.389e-70 245.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,43J74@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M Belongs to the ompA family yiaD - - - - - - - - - - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA MMS2_k127_3737146_4 472759.Nhal_2115 1.857e-47 175.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 MMS2_k127_3737146_1 340.xcc-b100_3920 5.547e-74 254.0 COG1247@1|root,COG1247@2|Bacteria,1RDNE@1224|Proteobacteria,1RR6A@1236|Gammaproteobacteria,1X6KZ@135614|Xanthomonadales 135614|Xanthomonadales M acetyltransferase yncA - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Acetyltransf_4 MMS2_k127_3737146_3 1120999.JONM01000001_gene1169 6.987e-61 225.0 COG2329@1|root,COG2329@2|Bacteria,1RAC6@1224|Proteobacteria,2VU6U@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF3291) - - - - - - - - - - - - DUF3291 MMS2_k127_3737146_2 626887.J057_10031 1.338e-70 244.0 COG1396@1|root,COG1396@2|Bacteria,1R4NU@1224|Proteobacteria,1RQG0@1236|Gammaproteobacteria,467PZ@72275|Alteromonadaceae 1236|Gammaproteobacteria K transcriptional ydcN GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - Cupin_2,HTH_3 MMS2_k127_3737146_0 626887.J057_10036 7.708e-170 542.0 COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,1RMD5@1236|Gammaproteobacteria,4660J@72275|Alteromonadaceae 1236|Gammaproteobacteria Q protein involved in benzoate metabolism benE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05782 - - - - ko00000,ko02000 2.A.46.1 - - BenE MMS2_k127_3737146_5 113395.AXAI01000013_gene6784 9.141e-41 154.0 COG1280@1|root,COG1280@2|Bacteria,1MWA1@1224|Proteobacteria,2U0HE@28211|Alphaproteobacteria,3JUPV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E LysE type translocator MA20_06410 - - - - - - - - - - - LysE MMS2_k127_3740801_3 396588.Tgr7_1353 3.527e-245 792.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales 135613|Chromatiales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 MMS2_k127_3740801_9 243159.AFE_2219 1.438e-95 322.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,2NC9N@225057|Acidithiobacillales 225057|Acidithiobacillales G Responsible for synthesis of pseudouridine from uracil - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 MMS2_k127_3740801_11 396588.Tgr7_1355 1.202e-68 238.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,1S3T3@1236|Gammaproteobacteria,1WVZ9@135613|Chromatiales 135613|Chromatiales S subfamily IA, variant 1 - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 MMS2_k127_3740801_7 713586.KB900536_gene297 3.825e-102 345.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1WWM5@135613|Chromatiales 135613|Chromatiales OU PFAM peptidase S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 MMS2_k127_3740801_12 519989.ECTPHS_10391 2.14e-64 240.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,1WX51@135613|Chromatiales 135613|Chromatiales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf MMS2_k127_3740801_0 396588.Tgr7_1916 8.887e-293 908.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA MMS2_k127_3740801_1 396588.Tgr7_1915 5.31e-251 784.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales 135613|Chromatiales I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase - - 6.4.1.1 ko:K01959 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 MMS2_k127_3740801_16 1240350.AMZE01000070_gene4511 2.249e-17 88.0 COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,1RRK3@1236|Gammaproteobacteria,1YWU0@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Uncharacterized ACR, COG1399 yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 MMS2_k127_3740801_15 272624.lpg1391 2.017e-25 106.0 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1JF7R@118969|Legionellales 118969|Legionellales J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p MMS2_k127_3740801_6 713586.KB900536_gene790 3.402e-140 452.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis MMS2_k127_3740801_5 2340.JV46_14790 1.363e-159 523.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360 ACP_syn_III,ACP_syn_III_C MMS2_k127_3740801_13 1123400.KB904758_gene2369 2.816e-64 223.0 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,460U2@72273|Thiotrichales 72273|Thiotrichales S CYTH - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH MMS2_k127_3740801_10 631362.Thi970DRAFT_04587 8.883e-89 301.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales 135613|Chromatiales L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG MMS2_k127_3740801_2 1158762.KB898046_gene506 9.454e-250 784.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N MMS2_k127_3740801_14 396588.Tgr7_1906 8.253e-64 225.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1WXKW@135613|Chromatiales 135613|Chromatiales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf MMS2_k127_3740801_17 1122164.JHWF01000022_gene1710 2.059e-16 82.0 2APXH@1|root,31F27@2|Bacteria,1QCFC@1224|Proteobacteria,1T85P@1236|Gammaproteobacteria,1JGAF@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - MMS2_k127_3740801_4 29581.BW37_03804 1.795e-160 526.0 COG2831@1|root,COG2831@2|Bacteria,1MXF6@1224|Proteobacteria,2VJHW@28216|Betaproteobacteria,473PR@75682|Oxalobacteraceae 28216|Betaproteobacteria U activation secretion protein - - - - - - - - - - - - POTRA_2,POTRA_3,ShlB MMS2_k127_3740801_8 1123368.AUIS01000001_gene1936 5.829e-97 328.0 COG3210@1|root,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,1RNRK@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Large exoproteins involved in heme utilization or adhesion - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,PT-VENN MMS2_k127_374744_2 631362.Thi970DRAFT_00716 3.603e-42 160.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales 135613|Chromatiales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate tsaC - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC MMS2_k127_374744_0 519989.ECTPHS_01134 0.0 1157.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom MMS2_k127_374744_1 713587.THITH_15600 7.372e-57 201.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales 135613|Chromatiales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 MMS2_k127_374744_3 713586.KB900536_gene2232 7.663e-16 79.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales 135613|Chromatiales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A MMS2_k127_3808451_2 1123228.AUIH01000004_gene1085 1.631e-115 378.0 COG1975@1|root,COG1975@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales 135619|Oceanospirillales O XdhC Rossmann domain - - - - - - - - - - - - XdhC_C,XdhC_CoxI MMS2_k127_3808451_8 1123228.AUIH01000004_gene1086 2.217e-59 213.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria 1224|Proteobacteria H MobA-Related Protein - - 1.1.1.328,2.7.7.76 ko:K07141,ko:K19190 ko00760,ko00790,ko01120,map00760,map00790,map01120 - R10131,R10132,R11582 RC03053 ko00000,ko00001,ko01000 - - - NTP_transf_3 MMS2_k127_3808451_4 1123228.AUIH01000004_gene1087 5.88e-107 356.0 COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales 135619|Oceanospirillales O XdhC Rossmann domain - - - - - - - - - - - - XdhC_C,XdhC_CoxI MMS2_k127_3808451_3 1123228.AUIH01000004_gene1088 1.238e-111 373.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,1RZ5Y@1236|Gammaproteobacteria,1XJEQ@135619|Oceanospirillales 135619|Oceanospirillales S COG3552 Protein containing von Willebrand factor type A (vWA) domain - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE MMS2_k127_3808451_1 1123228.AUIH01000004_gene1089 4.484e-122 402.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RZDH@1236|Gammaproteobacteria,1XIX3@135619|Oceanospirillales 135619|Oceanospirillales S ATPase, AAA - - - - - - - - - - - - AAA_5 MMS2_k127_3808451_5 1123401.JHYQ01000009_gene2291 1.703e-96 318.0 COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,1RRB4@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA MMS2_k127_3808451_7 1123228.AUIH01000004_gene1090 2.25e-63 223.0 COG3427@1|root,COG3427@2|Bacteria,1PJ51@1224|Proteobacteria,1SGFU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Carbon monoxide dehydrogenase subunit G (CoxG) - - - - - - - - - - - - COXG MMS2_k127_3808451_0 1123228.AUIH01000004_gene1091 0.0 1352.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1XRUQ@135619|Oceanospirillales 135619|Oceanospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.17.1.4,1.3.99.8 ko:K11177,ko:K16877 ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120 M00546 R01768,R02103,R02987 RC00143,RC01856 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2 MMS2_k127_3808451_6 266265.Bxe_A2145 3.493e-77 267.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ75@28216|Betaproteobacteria,1K322@119060|Burkholderiaceae 28216|Betaproteobacteria C [2Fe-2S] binding domain - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 MMS2_k127_3808451_9 1408164.MOLA814_02456 1.159e-42 159.0 COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VSFQ@28216|Betaproteobacteria 28216|Betaproteobacteria C Dehydrogenase - - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 MMS2_k127_3831531_1 1205680.CAKO01000002_gene2294 8.883e-107 352.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2TRK7@28211|Alphaproteobacteria,2JQ3W@204441|Rhodospirillales 204441|Rhodospirillales K COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR MMS2_k127_3831531_2 195253.Syn6312_1329 5.956e-92 309.0 COG0500@1|root,COG2226@2|Bacteria,1G24H@1117|Cyanobacteria,1H0C4@1129|Synechococcus 1117|Cyanobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 MMS2_k127_3831531_3 667632.KB890217_gene4883 9.779e-40 152.0 COG4154@1|root,COG4154@2|Bacteria,1RFUI@1224|Proteobacteria,2VRUE@28216|Betaproteobacteria,1K4HX@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the RbsD FucU family - - 5.1.3.29 ko:K02431 - - R10764 RC00563 ko00000,ko01000 - - - RbsD_FucU MMS2_k127_3831531_0 1144319.PMI16_01362 4.848e-143 463.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VZC2@28216|Betaproteobacteria,472SP@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red MMS2_k127_3845355_4 1218075.BAYA01000003_gene679 3.277e-47 174.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2VHBH@28216|Betaproteobacteria,1JZWX@119060|Burkholderiaceae 28216|Betaproteobacteria C ubiquinol oxidase subunit cyoA2 - 1.10.3.10 ko:K02297 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX2,COX_ARM MMS2_k127_3845355_1 522306.CAP2UW1_1027 2.48e-59 220.0 COG2206@1|root,COG2206@2|Bacteria,1RGJH@1224|Proteobacteria,2VSRC@28216|Betaproteobacteria 28216|Betaproteobacteria T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD_5 MMS2_k127_3845355_0 765913.ThidrDRAFT_2444 1.366e-141 460.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,1RPX5@1236|Gammaproteobacteria,1WX96@135613|Chromatiales 135613|Chromatiales C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red MMS2_k127_3845355_2 266117.Rxyl_0955 7.434e-50 193.0 COG2095@1|root,COG2095@2|Bacteria,2GMCM@201174|Actinobacteria 201174|Actinobacteria U UPF0056 membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC MMS2_k127_3845355_3 870187.Thini_4142 9.391e-49 177.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,462PQ@72273|Thiotrichales 72273|Thiotrichales CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C MMS2_k127_3877941_2 1234364.AMSF01000024_gene3813 5.269e-94 313.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1X5DD@135614|Xanthomonadales 135614|Xanthomonadales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri MMS2_k127_3877941_0 1234364.AMSF01000024_gene3814 1.423e-135 433.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1X4FR@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM MMS2_k127_3877941_1 1234364.AMSF01000024_gene3815 1.443e-121 393.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1X3TT@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC MMS2_k127_3877941_3 1234364.AMSF01000024_gene3816 7.574e-83 285.0 COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,1RQET@1236|Gammaproteobacteria,1X8E1@135614|Xanthomonadales 135614|Xanthomonadales S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 MMS2_k127_3880808_2 1370122.JHXQ01000001_gene438 7.096e-22 100.0 28VS5@1|root,2ZHU0@2|Bacteria,1P55S@1224|Proteobacteria,2VCM3@28211|Alphaproteobacteria,4B8WA@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_3880808_1 1122603.ATVI01000005_gene3302 8.905e-88 298.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1X41E@135614|Xanthomonadales 135614|Xanthomonadales S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase MMS2_k127_3880808_0 1123257.AUFV01000001_gene1646 0.0 1022.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1X4C5@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N MMS2_k127_3891714_1 1158292.JPOE01000005_gene760 1.44e-127 414.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2VKXA@28216|Betaproteobacteria,1KJET@119065|unclassified Burkholderiales 28216|Betaproteobacteria S 40-residue YVTN family beta-propeller repeat protein - - - - - - - - - - - - Cytochrom_D1,Lactonase MMS2_k127_3891714_0 1158292.JPOE01000002_gene1930 2.686e-150 488.0 COG2755@1|root,COG2755@2|Bacteria,1MXBN@1224|Proteobacteria,2W9TY@28216|Betaproteobacteria,1KNE7@119065|unclassified Burkholderiales 28216|Betaproteobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 MMS2_k127_3891714_2 396588.Tgr7_0100 8.236e-107 349.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC MMS2_k127_3891714_3 596154.Alide2_4122 1.04e-10 68.0 2DMYI@1|root,32UE4@2|Bacteria,1N1WA@1224|Proteobacteria,2WFYE@28216|Betaproteobacteria,4AEVP@80864|Comamonadaceae 28216|Betaproteobacteria S YXWGXW repeat (2 copies) - - - - - - - - - - - - YXWGXW MMS2_k127_392718_12 357804.Ping_3708 1.665e-60 214.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,2QJ8J@267894|Psychromonadaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD MMS2_k127_392718_2 472759.Nhal_3356 1.851e-127 434.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXP0@135613|Chromatiales 135613|Chromatiales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD MMS2_k127_392718_9 472759.Nhal_3355 1.076e-83 302.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1WXIC@135613|Chromatiales 135613|Chromatiales V PFAM ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_392718_4 472759.Nhal_3354 1.997e-114 381.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1WXMI@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3,HlyD_D23 MMS2_k127_392718_14 396588.Tgr7_0644 4.291e-46 169.0 COG4390@1|root,COG4390@2|Bacteria,1N8RK@1224|Proteobacteria,1SH14@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2322) - - - - - - - - - - - - DUF2322 MMS2_k127_392718_7 555778.Hneap_1217 1.068e-100 336.0 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1WZZ8@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase family - - - - - - - - - - - - Inositol_P MMS2_k127_392718_0 1123261.AXDW01000017_gene3126 5.253e-188 604.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RN7X@1236|Gammaproteobacteria,1X3MF@135614|Xanthomonadales 135614|Xanthomonadales I acyl-coa dehydrogenase - - - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M MMS2_k127_392718_8 713586.KB900536_gene1876 4.785e-85 295.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1WVUK@135613|Chromatiales 135613|Chromatiales C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 MMS2_k127_392718_5 426114.THI_0658 4.54e-113 374.0 COG1968@1|root,COG1968@2|Bacteria,1QVHA@1224|Proteobacteria,2VREJ@28216|Betaproteobacteria,1KP5P@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP2 - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA MMS2_k127_392718_6 519989.ECTPHS_09028 2.884e-111 363.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales 135613|Chromatiales L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD MMS2_k127_392718_13 545264.KB898747_gene416 7.697e-59 209.0 2FI57@1|root,349XX@2|Bacteria,1P0BB@1224|Proteobacteria,1SR8E@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_392718_11 243233.MCA2894 1.508e-66 235.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,1XF61@135618|Methylococcales 135618|Methylococcales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 MMS2_k127_392718_1 1116369.KB890024_gene2927 6.883e-139 449.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,43HHC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria V ABC transporter hndI GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_392718_3 1097668.BYI23_B010060 2.429e-121 396.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VJMJ@28216|Betaproteobacteria,1K058@119060|Burkholderiaceae 28216|Betaproteobacteria V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane MMS2_k127_392718_10 595537.Varpa_1465 2.079e-77 264.0 COG1280@1|root,COG1280@2|Bacteria,1R4PK@1224|Proteobacteria,2WFMN@28216|Betaproteobacteria 28216|Betaproteobacteria E Lysine transporter LysE - - - - - - - - - - - - LysE MMS2_k127_3968256_17 1288494.EBAPG3_21390 1.842e-09 60.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2VU0P@28216|Betaproteobacteria,373HX@32003|Nitrosomonadales 28216|Betaproteobacteria U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG MMS2_k127_3968256_8 1255043.TVNIR_3125 3.517e-101 333.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 MMS2_k127_3968256_9 519989.ECTPHS_07047 7.313e-98 325.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa MMS2_k127_3968256_2 713587.THITH_12975 3.481e-254 786.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa MMS2_k127_3968256_11 396588.Tgr7_0990 7.779e-81 275.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, E subunit - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx MMS2_k127_3968256_5 396588.Tgr7_0991 5.893e-241 749.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB MMS2_k127_3968256_0 396588.Tgr7_0992 9.608e-296 928.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 MMS2_k127_3968256_7 1269813.ATUL01000008_gene1511 1.51e-170 542.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh MMS2_k127_3968256_10 1286106.MPL1_06285 7.922e-88 293.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,460DI@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 MMS2_k127_3968256_12 519989.ECTPHS_07082 4.679e-68 244.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales 135613|Chromatiales C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 MMS2_k127_3968256_14 1269813.ATUL01000008_gene1508 3.114e-44 163.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1WYHG@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 MMS2_k127_3968256_1 472759.Nhal_3689 8.545e-280 873.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N MMS2_k127_3968256_4 396588.Tgr7_0998 2.559e-247 771.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M MMS2_k127_3968256_6 396588.Tgr7_0999 6.674e-187 595.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M MMS2_k127_3968256_15 396588.Tgr7_1000 3.764e-31 127.0 2BW9S@1|root,32Z6F@2|Bacteria,1N7ID@1224|Proteobacteria,1SDWS@1236|Gammaproteobacteria,1X22K@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2818) - - - - - - - - - - - - DUF2818 MMS2_k127_3968256_18 1229780.BN381_130143 2.807e-08 57.0 2DREZ@1|root,33BFB@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS2_k127_3968256_13 519989.ECTPHS_07237 3.689e-52 190.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1WY8Z@135613|Chromatiales 135613|Chromatiales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C MMS2_k127_3968256_3 396588.Tgr7_1002 8.101e-250 778.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 MMS2_k127_3968256_16 396588.Tgr7_1003 1.27e-28 124.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc MMS2_k127_4022263_1 519989.ECTPHS_02511 8.047e-115 382.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE MMS2_k127_4022263_0 1304275.C41B8_10288 9.489e-157 520.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase MMS2_k127_4032319_38 314278.NB231_07787 2.86e-41 159.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales 135613|Chromatiales M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L MMS2_k127_4032319_14 713586.KB900536_gene1660 2.425e-132 432.0 COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1WX2Z@135613|Chromatiales 135613|Chromatiales E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc MMS2_k127_4032319_30 396588.Tgr7_2796 4.091e-67 231.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1WY24@135613|Chromatiales 135613|Chromatiales O redox protein, regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC MMS2_k127_4032319_19 396588.Tgr7_2798 6.646e-102 357.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1WW6P@135613|Chromatiales 135613|Chromatiales E Belongs to the TrpC family trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS,PRAI MMS2_k127_4032319_12 713586.KB900536_gene1665 9.352e-136 440.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 MMS2_k127_4032319_21 287.DR97_3602 3.348e-94 312.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1YEPV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria EH Peptidase C26 pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase MMS2_k127_4032319_3 187272.Mlg_2250 1.308e-215 679.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X0KT@135613|Chromatiales 135613|Chromatiales EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind MMS2_k127_4032319_28 290398.Csal_2728 2.863e-80 274.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,1RNFH@1236|Gammaproteobacteria,1XK16@135619|Oceanospirillales 135619|Oceanospirillales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ MMS2_k127_4032319_0 290398.Csal_2727 0.0 1242.0 COG0243@1|root,COG0243@2|Bacteria,1MU6B@1224|Proteobacteria,1RNXW@1236|Gammaproteobacteria,1XIPP@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding MMS2_k127_4032319_2 1380387.JADM01000001_gene471 1.416e-219 693.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1XIBP@135619|Oceanospirillales 135619|Oceanospirillales E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP MMS2_k127_4032319_37 883126.HMPREF9710_04499 9.563e-42 163.0 COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,4747P@75682|Oxalobacteraceae 28216|Betaproteobacteria S DUF218 domain - - - - - - - - - - - - DUF218 MMS2_k127_4032319_6 519989.ECTPHS_09278 2.407e-156 499.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales 135613|Chromatiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM MMS2_k127_4032319_26 187272.Mlg_0179 1.686e-81 280.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1WX46@135613|Chromatiales 135613|Chromatiales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB - 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB MMS2_k127_4032319_41 765914.ThisiDRAFT_1639 2.228e-19 90.0 COG2921@1|root,COG2921@2|Bacteria 2|Bacteria S Belongs to the UPF0250 family ybeD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09158 - - - - ko00000 - - - DUF493 MMS2_k127_4032319_18 396588.Tgr7_2706 2.363e-111 366.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 MMS2_k127_4032319_10 1304275.C41B8_13490 2.158e-150 486.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 MMS2_k127_4032319_33 1049564.TevJSym_ao00690 3.223e-58 211.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1J5ZU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR MMS2_k127_4032319_20 1304275.C41B8_13490 3.437e-95 326.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 MMS2_k127_4032319_32 765914.ThisiDRAFT_1435 1.718e-59 216.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales 135613|Chromatiales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR MMS2_k127_4032319_22 314278.NB231_15853 4.18e-94 335.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1WWUA@135613|Chromatiales 135613|Chromatiales M Lytic murein transglycosylase B - - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 MMS2_k127_4032319_7 765914.ThisiDRAFT_1433 3.259e-152 488.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE MMS2_k127_4032319_4 713586.KB900536_gene2641 3.631e-211 675.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase MMS2_k127_4032319_29 426114.THI_0558 1.694e-79 268.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria,1KJXW@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase MMS2_k127_4032319_25 396588.Tgr7_2713 2.323e-88 300.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales 135613|Chromatiales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid MMS2_k127_4032319_5 396588.Tgr7_2714 4.634e-185 602.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales 135613|Chromatiales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C MMS2_k127_4032319_16 713586.KB900536_gene2637 8.661e-119 396.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1WVWN@135613|Chromatiales 135613|Chromatiales M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N MMS2_k127_4032319_13 713586.KB900536_gene2636 4.559e-135 438.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales 135613|Chromatiales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA MMS2_k127_4032319_23 396588.Tgr7_2718 3.394e-92 325.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales 135613|Chromatiales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD MMS2_k127_4032319_17 396588.Tgr7_2719 1.169e-116 407.0 COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,1T2QT@1236|Gammaproteobacteria,1WWCJ@135613|Chromatiales 135613|Chromatiales H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA MMS2_k127_4032319_35 472759.Nhal_3051 1.169e-52 207.0 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1SYT9@1236|Gammaproteobacteria,1X25R@135613|Chromatiales 135613|Chromatiales G PFAM glucosamine galactosamine-6-phosphate isomerase - - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso MMS2_k127_4032319_27 519989.ECTPHS_02561 7.089e-81 284.0 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1WW69@135613|Chromatiales 135613|Chromatiales G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase MMS2_k127_4032319_31 472759.Nhal_0212 1.039e-64 228.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales 135613|Chromatiales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 MMS2_k127_4032319_39 519989.ECTPHS_03909 7.546e-36 141.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX MMS2_k127_4032319_36 187272.Mlg_0347 2.486e-51 203.0 COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,1S6WA@1236|Gammaproteobacteria,1WXPI@135613|Chromatiales 135613|Chromatiales F phosphoribosyltransferase pyrR - 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran MMS2_k127_4032319_9 1269813.ATUL01000022_gene818 1.8e-150 493.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1WWU0@135613|Chromatiales 135613|Chromatiales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N MMS2_k127_4032319_8 713586.KB900536_gene1704 4.977e-152 491.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,1T03U@1236|Gammaproteobacteria,1WVVC@135613|Chromatiales 135613|Chromatiales F TIGRFAM dihydroorotase, multifunctional complex type - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 MMS2_k127_4032319_15 396588.Tgr7_2915 2.686e-124 421.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind MMS2_k127_4032319_40 1278309.KB907103_gene996 5.642e-25 113.0 COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,1S7CW@1236|Gammaproteobacteria,1XKD0@135619|Oceanospirillales 135619|Oceanospirillales S Pfam Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin MMS2_k127_4032319_11 926550.CLDAP_34700 8.587e-143 465.0 COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi 200795|Chloroflexi E aromatic amino acid beta-eliminating lyase threonine aldolase gly1 - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase MMS2_k127_4032319_34 1346791.M529_09025 9.537e-55 204.0 COG4340@1|root,COG4340@2|Bacteria,1R9YQ@1224|Proteobacteria,2U65P@28211|Alphaproteobacteria,2K52D@204457|Sphingomonadales 204457|Sphingomonadales S 2OG-Fe dioxygenase - - - - - - - - - - - - 2OG-Fe_Oxy_2 MMS2_k127_4032319_24 1279019.ARQK01000012_gene145 6.772e-91 306.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1WY0S@135613|Chromatiales 135613|Chromatiales O PFAM 20S proteasome, A and B subunits - - - ko:K07395 - - - - ko00000 - - - Proteasome MMS2_k127_4032319_1 1123279.ATUS01000002_gene17 4.219e-252 791.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,1J4WH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0514 Superfamily II DNA helicase recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind MMS2_k127_4042431_2 1174528.JH992888_gene278 1.773e-12 67.0 COG1961@1|root,COG1961@2|Bacteria,1G67F@1117|Cyanobacteria 1117|Cyanobacteria L DNA invertase Pin homologs - - - - - - - - - - - - HTH_7,Resolvase MMS2_k127_4042431_0 1174528.JH992888_gene279 1.503e-220 697.0 COG2801@1|root,COG2801@2|Bacteria,1G227@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Integrase core domain - - - - - - - - - - - - rve MMS2_k127_4042431_1 1170562.Cal6303_5633 9.168e-128 423.0 COG3267@1|root,COG3267@2|Bacteria,1GA9E@1117|Cyanobacteria,1HQUR@1161|Nostocales 1117|Cyanobacteria U COGs COG3267 Type II secretory pathway component ExeA - - - - - - - - - - - - AAA_22 MMS2_k127_4083819_4 1388763.O165_003060 1.027e-51 185.0 COG3214@1|root,COG3214@2|Bacteria,1N40B@1224|Proteobacteria,1RPYB@1236|Gammaproteobacteria,1YYG7@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Winged helix DNA-binding domain ycaQ - - ko:K09927 - - - - ko00000 - - - HTH_42 MMS2_k127_4083819_2 614083.AWQR01000010_gene1599 1.157e-66 236.0 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VQID@28216|Betaproteobacteria,4AF7M@80864|Comamonadaceae 28216|Betaproteobacteria S Phospholipase/Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 MMS2_k127_4083819_0 266265.Bxe_B2107 4.295e-112 368.0 COG0329@1|root,COG0329@2|Bacteria,1R45B@1224|Proteobacteria,2VJ5A@28216|Betaproteobacteria,1K4G6@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA2 - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS MMS2_k127_4083819_1 1123368.AUIS01000038_gene38 5.706e-78 267.0 COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,1S3SH@1236|Gammaproteobacteria,2NCU9@225057|Acidithiobacillales 225057|Acidithiobacillales S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran MMS2_k127_4083819_3 448385.sce0906 7.495e-62 217.0 COG0122@1|root,COG0350@1|root,COG0122@2|Bacteria,COG0350@2|Bacteria,1MVF7@1224|Proteobacteria,43ARM@68525|delta/epsilon subdivisions,2X65K@28221|Deltaproteobacteria,2Z392@29|Myxococcales 28221|Deltaproteobacteria L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,HhH-GPD MMS2_k127_4090213_4 1304275.C41B8_00305 1.252e-53 192.0 COG0683@1|root,COG0683@2|Bacteria,1QENW@1224|Proteobacteria,1S1AM@1236|Gammaproteobacteria 1236|Gammaproteobacteria E branched-chain amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS2_k127_4090213_0 1304275.C41B8_00300 2.069e-116 381.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,1RZ4X@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_4090213_1 859657.RPSI07_mp1339 4.032e-108 359.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VTRH@28216|Betaproteobacteria,1KGDS@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_4090213_2 1304275.C41B8_00290 2.075e-88 309.0 COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,1RR7E@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0411 ABC-type branched-chain amino acid transport systems ATPase component - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS2_k127_4090213_3 666684.AfiDRAFT_3038 1.94e-82 289.0 COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2TSRT@28211|Alphaproteobacteria,3JR1U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS2_k127_4106298_0 1007105.PT7_P058 2.038e-93 313.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2VRW1@28216|Betaproteobacteria,3T1RZ@506|Alcaligenaceae 28216|Betaproteobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal MMS2_k127_4106298_1 1007105.PT7_P057 1.375e-65 233.0 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,2VMZZ@28216|Betaproteobacteria,3T3QV@506|Alcaligenaceae 28216|Betaproteobacteria OU Clp protease - - - - - - - - - - - - CLP_protease MMS2_k127_4106298_2 1007105.PT7_P056 1.374e-62 227.0 COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2VP0D@28216|Betaproteobacteria,3T7PP@506|Alcaligenaceae 28216|Betaproteobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid MMS2_k127_4117698_6 713587.THITH_15670 3.843e-28 114.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales 135613|Chromatiales L Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC MMS2_k127_4117698_8 596154.Alide2_4122 1.08e-15 86.0 2DMYI@1|root,32UE4@2|Bacteria,1N1WA@1224|Proteobacteria,2WFYE@28216|Betaproteobacteria,4AEVP@80864|Comamonadaceae 28216|Betaproteobacteria S YXWGXW repeat (2 copies) - - - - - - - - - - - - YXWGXW MMS2_k127_4117698_5 713587.THITH_06730 9.524e-35 138.0 COG0664@1|root,COG0664@2|Bacteria,1RD80@1224|Proteobacteria,1S4Q2@1236|Gammaproteobacteria,1WY7A@135613|Chromatiales 135613|Chromatiales T PFAM Cyclic nucleotide-binding - - - - - - - - - - - - cNMP_binding MMS2_k127_4117698_1 713586.KB900536_gene2331 3.335e-150 485.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1WXCF@135613|Chromatiales 135613|Chromatiales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein MMS2_k127_4117698_4 1122604.JONR01000009_gene2418 1.916e-77 264.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1X61M@135614|Xanthomonadales 135614|Xanthomonadales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase MMS2_k127_4117698_0 323261.Noc_2994 3.047e-193 614.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1WXCY@135613|Chromatiales 135613|Chromatiales G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV MMS2_k127_4117698_2 396588.Tgr7_0104 1.099e-147 481.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales 135613|Chromatiales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase MMS2_k127_4117698_7 391615.ABSJ01000038_gene406 1.978e-17 90.0 COG2433@1|root,COG2433@2|Bacteria,1N0ZS@1224|Proteobacteria,1SBFE@1236|Gammaproteobacteria,1J6Y2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Pfam Transposase IS66 - - - - - - - - - - - - - MMS2_k127_4117698_3 396588.Tgr7_0108 1.993e-90 302.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1WWYM@135613|Chromatiales 135613|Chromatiales F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran MMS2_k127_4159426_0 396588.Tgr7_2622 5.095e-190 599.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind MMS2_k127_4159426_1 1395571.TMS3_0115055 1.563e-73 255.0 COG4221@1|root,COG4221@2|Bacteria,1NTNU@1224|Proteobacteria,1SD1N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short MMS2_k127_4159426_5 935567.JAES01000010_gene1788 5.865e-25 114.0 2ANQE@1|root,31DQ0@2|Bacteria,1QU29@1224|Proteobacteria,1T1MY@1236|Gammaproteobacteria,1X5ZS@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - DUF3298,DUF4163 MMS2_k127_4159426_2 1380394.JADL01000007_gene4661 1.415e-51 188.0 2DMMP@1|root,32SHG@2|Bacteria,1RM15@1224|Proteobacteria,2UAH7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4159426_3 666684.AfiDRAFT_1910 1.9e-34 140.0 COG0664@1|root,COG0664@2|Bacteria,1NCGM@1224|Proteobacteria,2UDQX@28211|Alphaproteobacteria,3K1NK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Cyclic nucleotide-monophosphate binding domain - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding MMS2_k127_4168807_2 713586.KB900536_gene1489 1.032e-05 50.0 COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1WZMR@135613|Chromatiales 135613|Chromatiales V Membrane protein required for beta-lactamase induction - - - ko:K03807 - - - - ko00000 - - - AmpE,CobD_Cbib MMS2_k127_4168807_1 713586.KB900536_gene1488 3.383e-50 186.0 COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1S69R@1236|Gammaproteobacteria,1WXZH@135613|Chromatiales 135613|Chromatiales G PFAM Phosphoglycerate mutase - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 MMS2_k127_4168807_0 1304883.KI912532_gene2702 2.214e-118 390.0 COG2206@1|root,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,2WEGM@28216|Betaproteobacteria,2KZV8@206389|Rhodocyclales 206389|Rhodocyclales T Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - HD_5 MMS2_k127_4182889_5 561230.PC1_1539 6.612e-14 76.0 2AFQE@1|root,315S9@2|Bacteria,1RHHZ@1224|Proteobacteria,1S7HB@1236|Gammaproteobacteria,1MSAB@122277|Pectobacterium 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4182889_3 102129.Lepto7375DRAFT_1543 2.413e-31 136.0 COG1309@1|root,COG1309@2|Bacteria,1G61G@1117|Cyanobacteria,1HFKG@1150|Oscillatoriales 1117|Cyanobacteria K WHG domain - - - - - - - - - - - - TetR_N,WHG MMS2_k127_4182889_2 1279019.ARQK01000061_gene1847 5.808e-64 241.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWT2@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_3 MMS2_k127_4182889_0 555778.Hneap_0360 2.636e-207 649.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RMKD@1236|Gammaproteobacteria,1WXNH@135613|Chromatiales 135613|Chromatiales P PFAM Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp MMS2_k127_4182889_6 234267.Acid_5809 0.0002601 52.0 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126 - - - - ko00000 - - - Sel1 MMS2_k127_4182889_1 1395571.TMS3_0114530 6.781e-96 323.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1525 DCD,dUTPase MMS2_k127_4182889_4 118163.Ple7327_0628 2.02e-30 124.0 COG0521@1|root,COG0521@2|Bacteria,1G514@1117|Cyanobacteria,3VJSK@52604|Pleurocapsales 1117|Cyanobacteria H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638,ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth MMS2_k127_4195863_8 765912.Thimo_2262 1.039e-28 123.0 COG1394@1|root,COG1394@2|Bacteria,1RJ1P@1224|Proteobacteria,1S75D@1236|Gammaproteobacteria,1WYND@135613|Chromatiales 135613|Chromatiales C ATP synthase subunit D - - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D MMS2_k127_4195863_1 2340.JV46_14280 4.575e-190 604.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab MMS2_k127_4195863_0 2340.JV46_14290 3.825e-217 688.0 COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1S12J@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit - - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn MMS2_k127_4195863_12 765912.Thimo_2265 9.967e-10 69.0 2DXMK@1|root,32V3Q@2|Bacteria,1N6HJ@1224|Proteobacteria,1SB4I@1236|Gammaproteobacteria,1WZ1G@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_4195863_13 765912.Thimo_2266 1.066e-09 67.0 COG1436@1|root,COG1436@2|Bacteria,1NFVS@1224|Proteobacteria,1SF77@1236|Gammaproteobacteria,1WZH0@135613|Chromatiales 135613|Chromatiales C ATP synthase (F/14-kDa) subunit - - - - - - - - - - - - ATP-synt_F MMS2_k127_4195863_10 1249627.D779_2944 6.911e-25 108.0 COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,1SBV1@1236|Gammaproteobacteria,1WZ48@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase proteolipid subunit family - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C MMS2_k127_4195863_4 768671.ThimaDRAFT_4701 1.194e-114 400.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria,1WX8D@135613|Chromatiales 135613|Chromatiales U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I MMS2_k127_4195863_11 1249627.D779_2942 5.524e-14 81.0 2C9YT@1|root,31Z2V@2|Bacteria,1RHIU@1224|Proteobacteria,1S6G3@1236|Gammaproteobacteria,1WYT4@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_4195863_6 713586.KB900536_gene317 8.726e-74 253.0 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1WYQS@135613|Chromatiales 135613|Chromatiales L PFAM NUDIX hydrolase - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX MMS2_k127_4195863_7 519989.ECTPHS_01419 8.592e-65 229.0 COG2365@1|root,COG2365@2|Bacteria,1REIM@1224|Proteobacteria,1S9GV@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Protein tyrosine serine phosphatase - - - - - - - - - - - - DUF442,Y_phosphatase3 MMS2_k127_4195863_5 519989.ECTPHS_01194 4.483e-74 261.0 COG1560@1|root,COG1560@2|Bacteria,1N9ZJ@1224|Proteobacteria,1RRI7@1236|Gammaproteobacteria,1X2ER@135613|Chromatiales 135613|Chromatiales M Bacterial lipid A biosynthesis acyltransferase - - 2.3.1.243 ko:K02560 ko00540,ko01100,map00540,map01100 M00060 R05075 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans MMS2_k127_4195863_2 1449976.KALB_6411 4.719e-129 421.0 COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4E11N@85010|Pseudonocardiales 201174|Actinobacteria S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS2_k127_4195863_3 1163407.UU7_03597 2.702e-128 418.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria,1X47R@135614|Xanthomonadales 135614|Xanthomonadales S Zn-dependent hydrolases including glyoxylases - - - - - - - - - - - - Lactamase_B MMS2_k127_4195863_9 323261.Noc_1573 3.587e-27 115.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 MMS2_k127_4202460_6 204773.HEAR0198 1.41e-12 68.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,473KA@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 MMS2_k127_4202460_2 1163409.UUA_05982 3.4e-115 376.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1X42P@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS MMS2_k127_4202460_4 1163408.UU9_07878 1.124e-63 229.0 COG0560@1|root,COG0560@2|Bacteria,1MWA9@1224|Proteobacteria,1RXX9@1236|Gammaproteobacteria,1X6FX@135614|Xanthomonadales 135614|Xanthomonadales E haloacid dehalogenase-like hydrolase - - 3.1.3.27 ko:K18697 ko00564,map00564 - R02029 RC00017 ko00000,ko00001,ko01000 - - - HAD MMS2_k127_4202460_3 1500890.JQNL01000001_gene1514 2.651e-107 356.0 COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,1Q5AK@1224|Proteobacteria,1S19Z@1236|Gammaproteobacteria,1X5VR@135614|Xanthomonadales 135614|Xanthomonadales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,MarR_2 MMS2_k127_4202460_1 1163409.UUA_05967 1.542e-123 400.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1X3QC@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator clp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0017076,GO:0019001,GO:0019219,GO:0019222,GO:0030551,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032561,GO:0035438,GO:0036094,GO:0043167,GO:0043168,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,HTH_Crp_2,cNMP_binding MMS2_k127_4202460_0 1234364.AMSF01000060_gene964 4.235e-156 500.0 COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1X32W@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine speD - 4.1.1.50 ko:K01611 ko00270,ko00330,ko01100,map00270,map00330,map01100 M00034,M00133 R00178 RC00299 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc MMS2_k127_4202460_5 1234364.AMSF01000060_gene963 5.398e-57 200.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1X4J6@135614|Xanthomonadales 135614|Xanthomonadales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 MMS2_k127_4228794_1 608538.HTH_1637 8.715e-14 76.0 2DNS1@1|root,32YVX@2|Bacteria,2G4CS@200783|Aquificae 200783|Aquificae S Protein of unknown function (DUF2905) - - - - - - - - - - - - DUF2905 MMS2_k127_4228794_0 234267.Acid_0298 9.86e-123 408.0 COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria 57723|Acidobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 MMS2_k127_4228794_2 1340493.JNIF01000003_gene3087 1.036e-07 53.0 COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria 57723|Acidobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C MMS2_k127_4248139_0 391937.NA2_14577 1.155e-94 325.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10111,ko:K10112,ko:K10191 ko02010,map02010 M00194,M00196,M00197,M00199,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.1.4 - - ABC_tran,TOBE_2 MMS2_k127_4248139_1 388739.RSK20926_20177 8.938e-59 216.0 COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TU85@28211|Alphaproteobacteria,2P329@2433|Roseobacter 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 MMS2_k127_4248139_2 536019.Mesop_3399 3.559e-47 183.0 COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2U1YY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1175 ABC-type sugar transport systems permease components - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 MMS2_k127_4253754_6 396588.Tgr7_1488 1.251e-65 229.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1WW3I@135613|Chromatiales 135613|Chromatiales C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488 - - - - ko00000 - - - NifU_N MMS2_k127_4253754_5 545276.KB898728_gene14 3.789e-72 246.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 MMS2_k127_4253754_9 1158165.KB898872_gene756 8.945e-34 137.0 COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria,1WYT2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1249) - - - ko:K09920 - - - - ko00000 - - - DUF1249 MMS2_k127_4253754_1 321332.CYB_2304 1.046e-235 740.0 COG0033@1|root,COG0033@2|Bacteria,1G0ZB@1117|Cyanobacteria,1GZ0J@1129|Synechococcus 1117|Cyanobacteria G Phosphoglucomutase pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV MMS2_k127_4253754_4 1283300.ATXB01000001_gene777 8.441e-86 289.0 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,1RQ3M@1236|Gammaproteobacteria,1XG51@135618|Methylococcales 135618|Methylococcales P Cation efflux family - - - - - - - - - - - - Cation_efflux MMS2_k127_4253754_7 1158760.AQXP01000041_gene1945 1.201e-54 195.0 COG0694@1|root,COG0694@2|Bacteria,1NHWB@1224|Proteobacteria,1SSTK@1236|Gammaproteobacteria 1236|Gammaproteobacteria O NifU-like domain - - - ko:K19168 - - - - ko00000,ko02048 - - - NifU MMS2_k127_4253754_12 472759.Nhal_0711 6.09e-20 95.0 2DTQ5@1|root,33M9A@2|Bacteria,1QVBF@1224|Proteobacteria,1T2B4@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - ko:K19168 - - - - ko00000,ko02048 - - - - MMS2_k127_4253754_13 1049564.TevJSym_bk00030 2.506e-10 64.0 COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH ygfY GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 MMS2_k127_4253754_3 396588.Tgr7_1481 8.006e-130 417.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales 135613|Chromatiales C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 MMS2_k127_4253754_0 713586.KB900536_gene372 1.543e-306 953.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales 135613|Chromatiales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C MMS2_k127_4253754_11 396588.Tgr7_1466 9.75e-22 106.0 COG2142@1|root,COG2142@2|Bacteria 2|Bacteria C succinate dehydrogenase activity sdhD GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017004,GO:0017144,GO:0019752,GO:0020037,GO:0022607,GO:0022900,GO:0032991,GO:0034622,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0065003,GO:0070469,GO:0070470,GO:0071704,GO:0071840,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - e_coli_core.b0722,iAF1260.b0722,iAPECO1_1312.APECO1_1356,iB21_1397.B21_00671,iBWG_1329.BWG_0581,iE2348C_1286.E2348C_0602,iEC042_1314.EC042_0740,iECABU_c1320.ECABU_c07680,iECBD_1354.ECBD_2938,iECB_1328.ECB_00682,iECDH10B_1368.ECDH10B_0789,iECDH1ME8569_1439.ECDH1ME8569_0681,iECD_1391.ECD_00682,iECED1_1282.ECED1_0692,iECIAI1_1343.ECIAI1_0696,iECIAI39_1322.ECIAI39_0680,iECNA114_1301.ECNA114_0658,iECO103_1326.ECO103_0716,iECO111_1330.ECO111_0739,iECO26_1355.ECO26_0783,iECOK1_1307.ECOK1_0722,iECP_1309.ECP_0734,iECS88_1305.ECS88_0748,iECSE_1348.ECSE_0782,iECSF_1327.ECSF_0655,iECUMN_1333.ECUMN_0800,iECW_1372.ECW_m0777,iEKO11_1354.EKO11_3157,iETEC_1333.ETEC_0733,iEcDH1_1363.EcDH1_2913,iEcE24377_1341.EcE24377A_0749,iEcHS_1320.EcHS_A0770,iEcSMS35_1347.EcSMS35_0735,iEcolC_1368.EcolC_2933,iJO1366.b0722,iJR904.b0722,iLF82_1304.LF82_2100,iNRG857_1313.NRG857_03215,iSBO_1134.SBO_0580,iSDY_1059.SDY_0660,iSFV_1184.SFV_0613,iSF_1195.SF0575,iSFxv_1172.SFxv_0634,iSSON_1240.SSON_0673,iS_1188.S0588,iUMN146_1321.UM146_14010,iUMNK88_1353.UMNK88_758,iUTI89_1310.UTI89_C0718,iWFL_1372.ECW_m0777,iY75_1357.Y75_RS03755,ic_1306.c0800 Sdh_cyt MMS2_k127_4253754_10 765910.MARPU_02465 3.573e-28 118.0 COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,1SEBT@1236|Gammaproteobacteria,1WZ6I@135613|Chromatiales 135613|Chromatiales C TIGRFAM Succinate dehydrogenase, cytochrome b556 subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt MMS2_k127_4253754_2 713586.KB900536_gene369 1.692e-132 432.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales 135613|Chromatiales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C MMS2_k127_4253754_8 1123368.AUIS01000024_gene944 1.647e-34 138.0 COG3170@1|root,COG3170@2|Bacteria,1QDEM@1224|Proteobacteria,1S884@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF1207) - - - - - - - - - - - - DUF1207 MMS2_k127_4257169_1 1444309.JAQG01000115_gene3190 8.806e-80 289.0 COG2508@1|root,COG2508@2|Bacteria,1TRDF@1239|Firmicutes,4IUN0@91061|Bacilli,277PB@186822|Paenibacillaceae 91061|Bacilli QT Purine catabolism regulatory protein-like family - - - - - - - - - - - - HTH_30,PucR MMS2_k127_4257169_0 1444309.JAQG01000115_gene3191 1.128e-183 590.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4HD8E@91061|Bacilli,275V4@186822|Paenibacillaceae 91061|Bacilli H Aminotransferase class-III yodT - - - - - - - - - - - Aminotran_3 MMS2_k127_4271160_3 396588.Tgr7_1836 1.165e-106 352.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1WWNS@135613|Chromatiales 135613|Chromatiales I TIGRFAM malonyl CoA-acyl carrier protein transacylase - - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 MMS2_k127_4271160_7 323261.Noc_2598 3.391e-35 137.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1WZ35@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a MMS2_k127_4271160_0 396588.Tgr7_1838 0.0 1201.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N MMS2_k127_4271160_5 396588.Tgr7_1839 3.565e-50 180.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales 135613|Chromatiales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS MMS2_k127_4271160_1 765914.ThisiDRAFT_2393 2.615e-230 719.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1WVYY@135613|Chromatiales 135613|Chromatiales C TIGRFAM isocitrate dehydrogenase, NADP-dependent - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh MMS2_k127_4271160_6 396588.Tgr7_1841 6.518e-48 178.0 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,1X18A@135613|Chromatiales 135613|Chromatiales F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ - - - - - - - - - - - NUDIX MMS2_k127_4271160_2 626887.J057_20085 2.174e-151 495.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,464B7@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans MMS2_k127_4271160_4 1158150.KB906242_gene373 1.256e-54 198.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1WXGQ@135613|Chromatiales 135613|Chromatiales S High frequency lysogenization protein HflD homolog hflD - - ko:K07153 - - - - ko00000 - - - DUF489 MMS2_k127_4281377_25 349163.Acry_0550 9.744e-33 128.0 COG0697@1|root,COG0697@2|Bacteria,1PHRI@1224|Proteobacteria,2TUAQ@28211|Alphaproteobacteria,2JTIA@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_4281377_8 713586.KB900536_gene68 1.518e-166 530.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1WVY0@135613|Chromatiales 135613|Chromatiales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh MMS2_k127_4281377_6 95619.PM1_0209690 6.859e-183 577.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC MMS2_k127_4281377_15 713586.KB900536_gene66 2.18e-108 387.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1WVVA@135613|Chromatiales 135613|Chromatiales NU FimV C-terminal - - - ko:K08086 - - - - ko00000 - - - TPR_19 MMS2_k127_4281377_14 396588.Tgr7_1251 3.507e-112 369.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1WX2M@135613|Chromatiales 135613|Chromatiales J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 MMS2_k127_4281377_20 396588.Tgr7_1252 8.055e-71 245.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1WXEP@135613|Chromatiales 135613|Chromatiales E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI MMS2_k127_4281377_3 713586.KB900536_gene62 3.453e-217 678.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS2_k127_4281377_17 1266914.ATUK01000017_gene612 5.533e-102 347.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1WXGF@135613|Chromatiales 135613|Chromatiales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA MMS2_k127_4281377_10 519989.ECTPHS_11345 8.985e-141 451.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans MMS2_k127_4281377_11 713586.KB900536_gene59 1.828e-122 406.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1WWQD@135613|Chromatiales 135613|Chromatiales H Belongs to the folylpolyglutamate synthase family - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M MMS2_k127_4281377_26 519989.ECTPHS_05380 1.503e-28 123.0 COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1WZEE@135613|Chromatiales 135613|Chromatiales S Sporulation related domain - - - ko:K03749 - - - - ko00000 - - - SPOR MMS2_k127_4281377_23 519989.ECTPHS_05385 1.208e-46 172.0 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1WY7W@135613|Chromatiales 135613|Chromatiales S Colicin V production protein - - - ko:K03558 - - - - ko00000 - - - Colicin_V MMS2_k127_4281377_1 519989.ECTPHS_05390 4.76e-246 767.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,1WWAI@135613|Chromatiales 135613|Chromatiales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran MMS2_k127_4281377_22 1255043.TVNIR_1227 1.254e-54 199.0 COG1376@1|root,COG1376@2|Bacteria,1MYZT@1224|Proteobacteria,1S8PS@1236|Gammaproteobacteria,1WY8E@135613|Chromatiales 135613|Chromatiales S ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD MMS2_k127_4281377_30 351607.Acel_0025 3.819e-09 68.0 COG3391@1|root,COG3391@2|Bacteria,2I1IX@201174|Actinobacteria,4EVVE@85013|Frankiales 2|Bacteria S amine dehydrogenase activity zinT - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - - MMS2_k127_4281377_19 1051632.TPY_3360 1.635e-78 274.0 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - DUF1566,PQQ_2,PQQ_3 MMS2_k127_4281377_5 396588.Tgr7_0930 1.698e-190 602.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP MMS2_k127_4281377_16 519989.ECTPHS_00500 1.813e-102 347.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,1RPKA@1236|Gammaproteobacteria,1WXPP@135613|Chromatiales 135613|Chromatiales G pfam mofrl - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL MMS2_k127_4281377_27 1049564.TevJSym_aa02160 3.053e-26 117.0 2BXIA@1|root,2ZJ26@2|Bacteria,1P6T0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - MMS2_k127_4281377_28 380394.Lferr_1103 8.997e-20 94.0 2AD69@1|root,312V3@2|Bacteria,1QCQN@1224|Proteobacteria,1T8GM@1236|Gammaproteobacteria,2NCU5@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_4281377_18 519989.ECTPHS_00510 5.031e-82 283.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1WX0F@135613|Chromatiales 135613|Chromatiales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 MMS2_k127_4281377_21 396588.Tgr7_0934 1.79e-64 238.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales 135613|Chromatiales O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase MMS2_k127_4281377_7 713586.KB900536_gene2985 1.1e-169 545.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,1X0FN@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX2 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c MMS2_k127_4281377_4 396588.Tgr7_0936 1.065e-213 672.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales 135613|Chromatiales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g MMS2_k127_4281377_12 396588.Tgr7_0937 4.386e-118 388.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1WWX4@135613|Chromatiales 135613|Chromatiales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C MMS2_k127_4281377_33 1454202.PPBDW_140160___1 0.0003352 48.0 2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4281377_32 1122164.JHWF01000022_gene1733 5.352e-07 53.0 2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales 118969|Legionellales - - - - - - - - - - - - - - - MMS2_k127_4281377_9 396588.Tgr7_0938 6.125e-147 478.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales 135613|Chromatiales O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N MMS2_k127_4281377_13 713586.KB900536_gene2993 7.171e-113 373.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales 135613|Chromatiales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease MMS2_k127_4281377_2 519989.ECTPHS_10941 2.572e-229 714.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1WX82@135613|Chromatiales 135613|Chromatiales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX MMS2_k127_4281377_0 396588.Tgr7_0941 0.0 1259.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C MMS2_k127_4281377_24 1268239.PALB_33230 1.17e-35 137.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,2Q2S2@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding MMS2_k127_4309877_7 688245.CtCNB1_4574 1.497e-31 127.0 COG1131@1|root,COG1131@2|Bacteria,1MY19@1224|Proteobacteria,2VJ5R@28216|Betaproteobacteria,4AGR8@80864|Comamonadaceae 28216|Betaproteobacteria P AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_4309877_3 765914.ThisiDRAFT_1983 5.688e-170 543.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX4M@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE MMS2_k127_4309877_0 396588.Tgr7_2917 5.544e-200 627.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE MMS2_k127_4309877_1 396588.Tgr7_2918 3.979e-194 609.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE MMS2_k127_4309877_4 396588.Tgr7_2919 7.953e-83 280.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1WWUW@135613|Chromatiales 135613|Chromatiales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N MMS2_k127_4309877_5 396588.Tgr7_2920 2.118e-81 280.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales 135613|Chromatiales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer MMS2_k127_4309877_6 713586.KB900536_gene1711 3.347e-51 188.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT MMS2_k127_4309877_8 713586.KB900536_gene1712 3.56e-21 106.0 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1WYTV@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 MMS2_k127_4309877_2 765913.ThidrDRAFT_0476 1.646e-171 554.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1X0K4@135613|Chromatiales 135613|Chromatiales P Voltage gated chloride channel - - - - - - - - - - - - Voltage_CLC MMS2_k127_4345402_7 1123401.JHYQ01000023_gene1225 4.025e-109 362.0 COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1T9Q0@1236|Gammaproteobacteria,461SP@72273|Thiotrichales 72273|Thiotrichales H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C MMS2_k127_4345402_9 1185652.USDA257_c19990 2.645e-94 315.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,4BAQU@82115|Rhizobiaceae 28211|Alphaproteobacteria T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C MMS2_k127_4345402_5 1041147.AUFB01000004_gene4841 3.913e-132 437.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,4BC9E@82115|Rhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA MMS2_k127_4345402_1 1159870.KB907784_gene1411 8.238e-161 528.0 COG0715@1|root,COG0715@2|Bacteria,1R3SJ@1224|Proteobacteria,2VMUC@28216|Betaproteobacteria,3T8TC@506|Alcaligenaceae 28216|Betaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 MMS2_k127_4345402_6 1408418.JNJH01000026_gene595 2.696e-123 413.0 COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2TT6U@28211|Alphaproteobacteria,2JZKX@204441|Rhodospirillales 204441|Rhodospirillales P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 MMS2_k127_4345402_4 701347.Entcl_0537 3.557e-132 426.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria 1236|Gammaproteobacteria P (ABC) transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran MMS2_k127_4345402_2 290398.Csal_1426 3.508e-158 505.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1XNV3@135619|Oceanospirillales 135619|Oceanospirillales S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N MMS2_k127_4345402_14 1449347.JQLN01000007_gene1836 4.584e-46 173.0 COG1290@1|root,COG1290@2|Bacteria,2HG31@201174|Actinobacteria 201174|Actinobacteria C Cytochrome b(N-terminal)/b6/petB - - - - - - - - - - - - Cytochrom_B_N_2 MMS2_k127_4345402_12 1051632.TPY_3079 7.019e-59 216.0 COG1290@1|root,COG1290@2|Bacteria 2|Bacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - - - - - - - - - - Cytochrom_B_C MMS2_k127_4345402_8 1144343.PMI41_01560 9.578e-102 339.0 COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2TSDV@28211|Alphaproteobacteria,43I5K@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G pfkB family carbohydrate kinase kdgK GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008673,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB MMS2_k127_4345402_13 1380391.JIAS01000014_gene2195 1.21e-57 210.0 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,2JSJ5@204441|Rhodospirillales 204441|Rhodospirillales G KDPG and KHG aldolase - - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase MMS2_k127_4345402_3 396588.Tgr7_0286 4.893e-133 430.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RS05@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C MMS2_k127_4345402_10 580332.Slit_1371 5.509e-88 303.0 COG0840@1|root,COG0840@2|Bacteria,1R5W9@1224|Proteobacteria,2VKQP@28216|Betaproteobacteria,44V12@713636|Nitrosomonadales 28216|Betaproteobacteria NT SMART chemotaxis sensory transducer - - - - - - - - - - - - CZB,MCPsignal MMS2_k127_4345402_0 1120983.KB894570_gene1553 4.771e-163 525.0 COG0477@1|root,COG2814@2|Bacteria,1PGFQ@1224|Proteobacteria,2VCSD@28211|Alphaproteobacteria,1JQC0@119043|Rhodobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 MMS2_k127_4423628_0 519989.ECTPHS_03577 4.841e-228 726.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales 135613|Chromatiales L Helicase - - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2 MMS2_k127_4423628_1 713586.KB900536_gene638 1.21e-54 203.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1WX9X@135613|Chromatiales 135613|Chromatiales O PFAM Peptidase M22, glycoprotease - - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 MMS2_k127_442601_3 1163617.SCD_n02604 3.479e-231 725.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2VH45@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp MMS2_k127_442601_15 765912.Thimo_3100 3.738e-44 167.0 COG3038@1|root,COG3038@2|Bacteria,1NFHR@1224|Proteobacteria 1224|Proteobacteria C Prokaryotic cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB MMS2_k127_442601_20 713586.KB900536_gene330 1.902e-15 83.0 COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein acetylation - - - - - - - - - - - - - MMS2_k127_442601_13 75379.Tint_1705 4.783e-50 181.0 COG0239@1|root,COG0239@2|Bacteria,1PT8U@1224|Proteobacteria,2VYBD@28216|Betaproteobacteria,1KPBN@119065|unclassified Burkholderiales 28216|Betaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB MMS2_k127_442601_16 1158292.JPOE01000002_gene1517 8.981e-40 149.0 COG1993@1|root,COG1993@2|Bacteria 2|Bacteria T acr, cog1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 MMS2_k127_442601_17 269799.Gmet_0156 2.566e-37 145.0 COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,42U37@68525|delta/epsilon subdivisions,2WQ9M@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function, DUF488 - - - - - - - - - - - - DUF488 MMS2_k127_442601_9 1166948.JPZL01000001_gene3248 4.087e-90 330.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,1XMP7@135619|Oceanospirillales 135619|Oceanospirillales M D-alanyl-D-alanine carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 MMS2_k127_442601_5 1122201.AUAZ01000008_gene484 6.122e-198 625.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,4642I@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2368 Seryl_tRNA_N,tRNA-synt_2b MMS2_k127_442601_4 396588.Tgr7_1551 2.208e-200 632.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,1WW9I@135613|Chromatiales 135613|Chromatiales E PFAM aminotransferase class V - - 2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830,ko:K00839 ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588,R10908 RC00006,RC00008,RC00018,RC03305 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 MMS2_k127_442601_10 1283300.ATXB01000001_gene1280 3.012e-73 258.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XEK0@135618|Methylococcales 135618|Methylococcales O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB MMS2_k127_442601_11 215803.DB30_1753 1.194e-67 243.0 COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,42MF3@68525|delta/epsilon subdivisions,2WJXS@28221|Deltaproteobacteria,2YXMB@29|Myxococcales 28221|Deltaproteobacteria G Class II Aldolase and Adducin N-terminal domain fucA - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II MMS2_k127_442601_1 396588.Tgr7_2024 2.049e-285 893.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 MMS2_k127_442601_18 396588.Tgr7_2025 1.937e-27 130.0 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1WXRX@135613|Chromatiales 135613|Chromatiales D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA - - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C MMS2_k127_442601_19 519989.ECTPHS_05556 1.624e-21 111.0 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1WXRX@135613|Chromatiales 135613|Chromatiales D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA - - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C MMS2_k127_442601_0 396588.Tgr7_2026 0.0 1188.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge MMS2_k127_442601_12 314278.NB231_16133 5.789e-66 228.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales 135613|Chromatiales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF MMS2_k127_442601_7 396588.Tgr7_2028 9.653e-146 475.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1WW9A@135613|Chromatiales 135613|Chromatiales G PFAM carbohydrate kinase - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N MMS2_k127_442601_6 1304275.C41B8_03561 3.834e-194 617.0 COG4948@1|root,COG4948@2|Bacteria,1MVFW@1224|Proteobacteria,1RYMG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the mandelate racemase muconate lactonizing enzyme family - - 4.2.1.81 ko:K22209 - - - - ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N MMS2_k127_442601_14 1033802.SSPSH_000577 1.991e-46 171.0 2DN72@1|root,32VWT@2|Bacteria,1R35M@1224|Proteobacteria,1SV0Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB MMS2_k127_442601_2 1304275.C41B8_03571 2.634e-241 753.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tripartite tricarboxylate transporter TctA - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA,TctB MMS2_k127_442601_8 1304275.C41B8_03576 8.332e-132 424.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,1RSC6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S ABC transporter substrate-binding protein - - - - - - - - - - - - TctC MMS2_k127_4451038_0 243159.AFE_3118 7.702e-186 590.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RQS1@1236|Gammaproteobacteria,2NCAJ@225057|Acidithiobacillales 225057|Acidithiobacillales S PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS2_k127_4451038_3 1123393.KB891316_gene1811 2.781e-26 117.0 COG0425@1|root,COG0425@2|Bacteria,1NDVB@1224|Proteobacteria 1224|Proteobacteria O Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - TusA MMS2_k127_4451038_2 380394.Lferr_2714 1.9e-41 156.0 COG2210@1|root,COG2210@2|Bacteria,1NXM5@1224|Proteobacteria,1SREE@1236|Gammaproteobacteria,2NCZR@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 MMS2_k127_4451038_1 637389.Acaty_c2260 2.132e-97 326.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RM90@1236|Gammaproteobacteria,2NCQ3@225057|Acidithiobacillales 225057|Acidithiobacillales K PAS fold - - - - - - - - - - - - HTH_23,PAS_4,Sigma54_activat MMS2_k127_4485410_30 1123401.JHYQ01000007_gene516 5.127e-57 213.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,4616Y@72273|Thiotrichales 72273|Thiotrichales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI MMS2_k127_4485410_24 396588.Tgr7_2419 3.314e-82 286.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1WXAI@135613|Chromatiales 135613|Chromatiales H Phosphomethylpyrimidine kinase - - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin MMS2_k127_4485410_42 1163408.UU9_07181 1.624e-26 109.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,1SC8Q@1236|Gammaproteobacteria,1X88Q@135614|Xanthomonadales 135614|Xanthomonadales C rubredoxin rubA - - - - - - - - - - - Rubredoxin MMS2_k127_4485410_31 396588.Tgr7_2417 6.241e-48 175.0 290E0@1|root,2ZN3C@2|Bacteria,1P9RQ@1224|Proteobacteria,1SV1G@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4485410_23 713586.KB900536_gene1205 3.079e-83 283.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD MMS2_k127_4485410_28 396588.Tgr7_2415 4.677e-70 243.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales 135613|Chromatiales L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX MMS2_k127_4485410_0 519989.ECTPHS_02359 1.601e-308 963.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales 135613|Chromatiales T Belongs to the PEP-utilizing enzyme family - - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C MMS2_k127_4485410_37 519989.ECTPHS_02364 1.236e-41 159.0 COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,1S8ZA@1236|Gammaproteobacteria,1X1I8@135613|Chromatiales 135613|Chromatiales CO Glutathione peroxidase - - - - - - - - - - - - AhpC-TSA,Redoxin MMS2_k127_4485410_40 56110.Oscil6304_1013 1.192e-31 127.0 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel MMS2_k127_4485410_6 472759.Nhal_0326 2.103e-163 526.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales 135613|Chromatiales P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N MMS2_k127_4485410_5 1122603.ATVI01000006_gene202 1.337e-167 545.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1X33X@135614|Xanthomonadales 135614|Xanthomonadales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C MMS2_k127_4485410_41 396588.Tgr7_0720 2.062e-31 126.0 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1WYUA@135613|Chromatiales 135613|Chromatiales G Phosphotransferase System - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr MMS2_k127_4485410_36 396588.Tgr7_0721 6.15e-42 157.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,1SA62@1236|Gammaproteobacteria,1WYYD@135613|Chromatiales 135613|Chromatiales G system, fructose subfamily IIA component - - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man MMS2_k127_4485410_11 396588.Tgr7_0722 4.568e-125 406.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales 135613|Chromatiales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 MMS2_k127_4485410_22 519989.ECTPHS_01664 3.142e-90 307.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales 135613|Chromatiales T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N MMS2_k127_4485410_32 187272.Mlg_2232 1.237e-45 173.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales 135613|Chromatiales G PTS IIA-like nitrogen-regulatory protein PtsN - - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 MMS2_k127_4485410_35 187272.Mlg_2231 1.736e-42 158.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1WYWY@135613|Chromatiales 135613|Chromatiales J Sigma 54 modulation protein - - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE MMS2_k127_4485410_4 396588.Tgr7_0726 4.12e-185 592.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD MMS2_k127_4485410_17 713586.KB900536_gene1417 1.933e-104 353.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1WW0D@135613|Chromatiales 135613|Chromatiales S PFAM ABC transporter - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C MMS2_k127_4485410_43 396588.Tgr7_0728 9.859e-19 94.0 COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1WYD5@135613|Chromatiales 135613|Chromatiales T Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA,SH3_3 MMS2_k127_4485410_47 1144319.PMI16_01215 4.413e-06 59.0 COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VWU0@28216|Betaproteobacteria,474CV@75682|Oxalobacteraceae 28216|Betaproteobacteria S Lipopolysaccharide-assembly, LptC-related - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC MMS2_k127_4485410_29 396588.Tgr7_0730 5.913e-68 235.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1WY5Q@135613|Chromatiales 135613|Chromatiales S Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 MMS2_k127_4485410_10 519989.ECTPHS_01704 6.814e-145 467.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales 135613|Chromatiales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS MMS2_k127_4485410_13 396588.Tgr7_0732 1.318e-116 383.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales 135613|Chromatiales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex MMS2_k127_4485410_15 713586.KB900536_gene1411 2.742e-107 355.0 COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,1RWCX@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Nad-dependent epimerase dehydratase - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase MMS2_k127_4485410_8 396588.Tgr7_0734 8.099e-157 503.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,1SZ0Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase MMS2_k127_4485410_44 1049564.TevJSym_ag00270 2.448e-17 89.0 COG1801@1|root,COG1801@2|Bacteria,1NJGC@1224|Proteobacteria,1SHUQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - - MMS2_k127_4485410_12 519989.ECTPHS_01719 2.007e-123 401.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales 135613|Chromatiales Q PFAM ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran MMS2_k127_4485410_18 519989.ECTPHS_01724 6.559e-103 351.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE MMS2_k127_4485410_33 519989.ECTPHS_01729 1.629e-45 170.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1WXYG@135613|Chromatiales 135613|Chromatiales Q PFAM Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD MMS2_k127_4485410_38 265072.Mfla_0240 1.215e-34 141.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,2KME2@206350|Nitrosomonadales 206350|Nitrosomonadales Q PFAM toluene tolerance - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC MMS2_k127_4485410_46 349124.Hhal_2116 5.33e-10 64.0 COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1WZDQ@135613|Chromatiales 135613|Chromatiales S NTP binding protein (Contains STAS domain) - - - ko:K07122 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - STAS_2 MMS2_k127_4485410_3 396588.Tgr7_0742 3.751e-206 647.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase MMS2_k127_4485410_21 396588.Tgr7_0743 4.767e-95 317.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG MMS2_k127_4485410_7 713586.KB900536_gene1401 1.622e-162 520.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1WWKJ@135613|Chromatiales 135613|Chromatiales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 MMS2_k127_4485410_1 713586.KB900536_gene1400 7.706e-209 660.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,1WX79@135613|Chromatiales 135613|Chromatiales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh MMS2_k127_4485410_9 477228.YO5_04042 5.665e-145 487.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1YZZW@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 MMS2_k127_4485410_19 396588.Tgr7_0748 2.588e-102 338.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,1RNBU@1236|Gammaproteobacteria,1WY4I@135613|Chromatiales 135613|Chromatiales S NGG1p interacting factor 3 - - - - - - - - - - - - NIF3 MMS2_k127_4485410_27 396588.Tgr7_0752 2.139e-72 252.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1WWWN@135613|Chromatiales 135613|Chromatiales O PFAM Glutathione S-transferase sspA - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_C_2,GST_N_3 MMS2_k127_4485410_34 1335757.SPICUR_07705 2.731e-45 168.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1WYWV@135613|Chromatiales 135613|Chromatiales S Stringent starvation protein B - - - ko:K03600 - - - - ko00000,ko03021 - - - SspB MMS2_k127_4485410_16 1266914.ATUK01000010_gene1171 5.433e-105 348.0 COG2850@1|root,COG2850@2|Bacteria,1RDTN@1224|Proteobacteria,1SDPU@1236|Gammaproteobacteria,1WZM5@135613|Chromatiales 135613|Chromatiales S Cupin-like domain - - - - - - - - - - - - Cupin_8 MMS2_k127_4485410_2 396588.Tgr7_0755 1.244e-208 670.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WXBN@135613|Chromatiales 135613|Chromatiales C PFAM FAD linked oxidase domain protein - - 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 MMS2_k127_4485410_25 1123400.KB904754_gene1034 2.428e-78 266.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,460NU@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 MMS2_k127_4485410_39 713586.KB900536_gene1390 2.21e-32 131.0 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the UPF0102 family yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 MMS2_k127_4485410_14 713586.KB900536_gene1389 5.796e-109 377.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1WX80@135613|Chromatiales 135613|Chromatiales M PFAM LppC - - - ko:K07121 - - - - ko00000 - - - LppC MMS2_k127_4485410_20 713586.KB900536_gene1388 3.195e-102 340.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1WWCD@135613|Chromatiales 135613|Chromatiales H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase MMS2_k127_4485410_26 1158756.AQXQ01000012_gene1578 1.51e-75 263.0 COG4122@1|root,COG4122@2|Bacteria,1RB34@1224|Proteobacteria,1S02F@1236|Gammaproteobacteria,1WXYH@135613|Chromatiales 135613|Chromatiales S PFAM O-methyltransferase, family 3 - - - - - - - - - - - - Methyltransf_3 MMS2_k127_4485410_45 314287.GB2207_11628 2.325e-13 72.0 2DMTH@1|root,32TKP@2|Bacteria,1N4TE@1224|Proteobacteria,1S9K6@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4489512_3 472759.Nhal_3735 5.413e-77 262.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales 135613|Chromatiales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans MMS2_k127_4489512_2 713586.KB900536_gene609 9.961e-140 454.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales 135613|Chromatiales S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like MMS2_k127_4489512_1 768671.ThimaDRAFT_2432 9.479e-169 534.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS2_k127_4489512_0 713586.KB900536_gene612 8.956e-195 621.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma MMS2_k127_4518734_23 83406.HDN1F_07340 1.879e-30 123.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1J5X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase MMS2_k127_4518734_5 545264.KB898754_gene1822 9.287e-167 528.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh MMS2_k127_4518734_14 1242864.D187_009742 1.061e-73 256.0 COG0457@1|root,COG0457@2|Bacteria,1NFTN@1224|Proteobacteria,4329S@68525|delta/epsilon subdivisions 1224|Proteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - MMS2_k127_4518734_27 396588.Tgr7_3150 7.549e-11 70.0 2CJFH@1|root,2ZRS6@2|Bacteria,1P73K@1224|Proteobacteria,1SVKM@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4518734_20 1123368.AUIS01000018_gene728 2.299e-40 154.0 COG0589@1|root,COG0589@2|Bacteria,1N9BR@1224|Proteobacteria,1SFNQ@1236|Gammaproteobacteria,2NDEZ@225057|Acidithiobacillales 225057|Acidithiobacillales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp MMS2_k127_4518734_2 1094715.CM001375_gene135 7.874e-180 576.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1JCET@118969|Legionellales 118969|Legionellales U Sugar (and other) transporter - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 MMS2_k127_4518734_15 243159.AFE_0257 4.116e-71 253.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,2NBXK@225057|Acidithiobacillales 225057|Acidithiobacillales V Secretion protein, HlyD - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_D23 MMS2_k127_4518734_21 1123368.AUIS01000018_gene731 5.402e-33 132.0 COG1846@1|root,COG1846@2|Bacteria,1PC0Q@1224|Proteobacteria,1SXNR@1236|Gammaproteobacteria,2NDAB@225057|Acidithiobacillales 225057|Acidithiobacillales K Transcriptional regulator, MarR - - - ko:K06075 - - - - ko00000,ko03000 - - - MarR_2 MMS2_k127_4518734_25 713586.KB900536_gene1889 6.976e-17 83.0 2C07H@1|root,2ZCWQ@2|Bacteria,1P4TT@1224|Proteobacteria,1SV96@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4518734_3 396588.Tgr7_3071 1.931e-172 547.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1WWVD@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA MMS2_k127_4518734_17 396588.Tgr7_3070 1.702e-51 185.0 2F4VH@1|root,33XHQ@2|Bacteria,1NWSK@1224|Proteobacteria,1SPE7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4518734_19 713586.KB900536_gene1885 4.77e-44 171.0 COG0526@1|root,COG0526@2|Bacteria,1RHPC@1224|Proteobacteria,1S4C9@1236|Gammaproteobacteria,1X2AK@135613|Chromatiales 135613|Chromatiales CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Redoxin MMS2_k127_4518734_24 1165096.ARWF01000001_gene1123 6e-24 108.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,2KN03@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM Cytochrome C - - - - - - - - - - - - Cytochrome_CBB3 MMS2_k127_4518734_16 1123368.AUIS01000023_gene927 1.964e-55 201.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,2NBZ5@225057|Acidithiobacillales 225057|Acidithiobacillales U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC MMS2_k127_4518734_4 380394.Lferr_1405 4.416e-169 564.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NCFF@225057|Acidithiobacillales 225057|Acidithiobacillales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,Protoglobin MMS2_k127_4518734_1 870187.Thini_2806 6.491e-184 587.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,46042@72273|Thiotrichales 72273|Thiotrichales P Na H antiporter - - - - - - - - - - - - CitMHS MMS2_k127_4518734_0 713586.KB900536_gene2041 1.187e-253 796.0 COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXQ0@135613|Chromatiales 135613|Chromatiales P Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C MMS2_k127_4518734_7 396588.Tgr7_3240 2.263e-155 494.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales 135613|Chromatiales C PFAM Phosphoribulokinase uridine kinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK MMS2_k127_4518734_18 396588.Tgr7_3241 5.785e-50 183.0 2C8VW@1|root,347Y3@2|Bacteria,1P23D@1224|Proteobacteria,1SSAK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4518734_10 713586.KB900536_gene2043 1.779e-127 418.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,1WWYY@135613|Chromatiales 135613|Chromatiales S FIST N domain - - - - - - - - - - - - FIST,FIST_C MMS2_k127_4518734_6 626887.J057_03420 4.35e-164 524.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,464XR@72275|Alteromonadaceae 1236|Gammaproteobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) tas GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928 - - - - - - - - - - Aldo_ket_red MMS2_k127_4518734_8 1150474.JQJI01000016_gene561 9.917e-153 493.0 COG0025@1|root,COG0025@2|Bacteria 2|Bacteria P sodium:proton antiporter activity - - - - - - - - - - - - Na_H_Exchanger MMS2_k127_4518734_11 713586.KB900536_gene2045 1.74e-95 322.0 COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1WWHE@135613|Chromatiales 135613|Chromatiales L hydrolase, TatD family - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase MMS2_k127_4518734_13 519989.ECTPHS_01429 1.406e-77 280.0 COG1179@1|root,COG1179@2|Bacteria,1MWXR@1224|Proteobacteria,1RMT3@1236|Gammaproteobacteria,1WXXZ@135613|Chromatiales 135613|Chromatiales H PFAM UBA THIF-type NAD FAD binding - - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF MMS2_k127_4518734_22 637389.Acaty_c0743 1.405e-32 132.0 COG0589@1|root,COG0589@2|Bacteria,1QCSW@1224|Proteobacteria,1T8JT@1236|Gammaproteobacteria,2ND16@225057|Acidithiobacillales 225057|Acidithiobacillales T Universal stress protein family - - - - - - - - - - - - Usp MMS2_k127_4518734_9 637389.Acaty_c0744 1.4e-129 423.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,1T8C8@1236|Gammaproteobacteria,2NCKI@225057|Acidithiobacillales 225057|Acidithiobacillales S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE MMS2_k127_4518734_26 637389.Acaty_c0745 4.827e-14 85.0 2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,1T8IU@1236|Gammaproteobacteria,2NCZ7@225057|Acidithiobacillales 225057|Acidithiobacillales S Putative transmembrane protein (Alph_Pro_TM) - - - - - - - - - - - - Alph_Pro_TM MMS2_k127_4527241_4 247633.GP2143_16316 9.987e-89 297.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1J4RB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141 - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 MMS2_k127_4527241_3 713586.KB900536_gene1800 5.541e-94 331.0 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1WWEB@135613|Chromatiales 135613|Chromatiales D Part of the ABC transporter FtsEX involved in cellular division - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX MMS2_k127_4527241_2 519989.ECTPHS_06607 8.008e-97 322.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1WWPI@135613|Chromatiales 135613|Chromatiales D TIGRFAM Cell division ATP-binding protein FtsE - - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran MMS2_k127_4527241_1 396588.Tgr7_2988 5.75e-136 456.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N MMS2_k127_4527241_7 396588.Tgr7_2985 2.472e-57 205.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1WY3H@135613|Chromatiales 135613|Chromatiales L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 MMS2_k127_4527241_0 555778.Hneap_0053 1.216e-166 537.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales 135613|Chromatiales S RmuC family - - - ko:K09760 - - - - ko00000 - - - RmuC MMS2_k127_4527241_6 420324.KI912034_gene2609 1.271e-75 262.0 COG4977@1|root,COG4977@2|Bacteria,1QV1S@1224|Proteobacteria,2TYAD@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Cupin - - - - - - - - - - - - Cupin_6,HTH_18 MMS2_k127_4527241_5 420324.KI912034_gene2610 2.417e-85 286.0 COG0450@1|root,COG0450@2|Bacteria,1QWIV@1224|Proteobacteria,2TWYM@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin MMS2_k127_4527241_8 1040986.ATYO01000010_gene2974 1.725e-46 173.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TUAM@28211|Alphaproteobacteria,43PW5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short MMS2_k127_4532380_21 1286631.X805_21600 6.564e-71 243.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2VI5K@28216|Betaproteobacteria,1KJIB@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Eukaryotic-type carbonic anhydrase cah - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase,VPEP MMS2_k127_4532380_8 526227.Mesil_0159 5.694e-130 423.0 COG1609@1|root,COG1609@2|Bacteria,1WIS7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 MMS2_k127_4532380_4 526227.Mesil_0158 6.437e-190 603.0 COG1653@1|root,COG1653@2|Bacteria,1WJE6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Bacterial extracellular solute-binding protein - - - ko:K10227 ko02010,map02010 M00200 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.5 - - SBP_bac_1 MMS2_k127_4532380_11 1150469.RSPPHO_03135 1.278e-103 344.0 COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,2TTD0@28211|Alphaproteobacteria,2JPRQ@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 MMS2_k127_4532380_14 1304275.C41B8_13940 4.667e-96 326.0 COG1175@1|root,COG1175@2|Bacteria,1MVF1@1224|Proteobacteria,1RRHX@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter (permease) mtlF - - ko:K02025,ko:K05814,ko:K10228 ko02010,map02010 M00198,M00200,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.3,3.A.1.1.5 - - BPD_transp_1 MMS2_k127_4532380_12 1304275.C41B8_13945 9.447e-100 332.0 COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,1RQWF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type sugar transport system, permease component mtlG - - ko:K10229 ko02010,map02010 M00200 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.5 - - BPD_transp_1 MMS2_k127_4532380_16 649638.Trad_2889 4.165e-92 309.0 COG1028@1|root,COG1028@2|Bacteria,1WJW2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus IQ with different specificities (related to short-chain alcohol - - - - - - - - - - - - adh_short_C2 MMS2_k127_4532380_7 1304275.C41B8_14550 3.238e-148 479.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10111,ko:K10191 ko02010,map02010 M00194,M00199,M00200,M00204,M00207,M00491 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1,3.A.1.1.4 - - ABC_tran,TOBE_2 MMS2_k127_4532380_24 396588.Tgr7_2426 3.849e-58 204.0 COG3118@1|root,COG3118@2|Bacteria,1RHRZ@1224|Proteobacteria,1S7F0@1236|Gammaproteobacteria,1WYEG@135613|Chromatiales 135613|Chromatiales O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin MMS2_k127_4532380_26 395493.BegalDRAFT_3005 4.958e-51 197.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,1S54H@1236|Gammaproteobacteria,462T3@72273|Thiotrichales 72273|Thiotrichales S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg MMS2_k127_4532380_18 519989.ECTPHS_02309 1.442e-86 300.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales 135613|Chromatiales H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein MMS2_k127_4532380_3 396588.Tgr7_2447 3.696e-198 626.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1WWVU@135613|Chromatiales 135613|Chromatiales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M MMS2_k127_4532380_29 395493.BegalDRAFT_1523 7.641e-09 63.0 2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,4636E@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - MMS2_k127_4532380_10 519989.ECTPHS_11437 5.336e-110 369.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RNEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol clsB GO:0003674,GO:0003824,GO:0004620,GO:0004630,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008081,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016298,GO:0016740,GO:0016772,GO:0016780,GO:0016787,GO:0016788,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_0754 PLDc_2 MMS2_k127_4532380_23 765914.ThisiDRAFT_2466 1.297e-63 227.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1WW1D@135613|Chromatiales 135613|Chromatiales M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA MMS2_k127_4532380_2 1439940.BAY1663_01392 2.342e-230 716.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth MMS2_k127_4532380_28 1163398.AJJP01000014_gene3704 5.428e-27 122.0 COG2885@1|root,COG2885@2|Bacteria,1PGGZ@1224|Proteobacteria,1RNFU@1236|Gammaproteobacteria 1236|Gammaproteobacteria N COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins motY - - ko:K21218 ko02040,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA MMS2_k127_4532380_15 1123368.AUIS01000007_gene2715 1.515e-93 321.0 2BR9X@1|root,32K8F@2|Bacteria,1QCFX@1224|Proteobacteria,1T869@1236|Gammaproteobacteria,2NCD3@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_4532380_20 1123368.AUIS01000004_gene232 4.131e-81 286.0 COG3434@1|root,COG3434@2|Bacteria,1MVW1@1224|Proteobacteria,1RS25@1236|Gammaproteobacteria,2ND0J@225057|Acidithiobacillales 225057|Acidithiobacillales T HDOD domain - - - - - - - - - - - - EAL,HDOD MMS2_k127_4532380_22 205922.Pfl01_2160 3.128e-70 243.0 COG1280@1|root,COG1280@2|Bacteria,1RECX@1224|Proteobacteria,1S49M@1236|Gammaproteobacteria,1YN55@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE MMS2_k127_4532380_27 641491.DND132_0139 1.805e-49 182.0 COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,42TQP@68525|delta/epsilon subdivisions,2WRPZ@28221|Deltaproteobacteria,2MC5U@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM YbaK prolyl-tRNA synthetase associated region - - - - - - - - - - - - tRNA_edit MMS2_k127_4532380_1 1123401.JHYQ01000015_gene1432 2.267e-252 790.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,45ZSE@72273|Thiotrichales 72273|Thiotrichales C dihydrolipoamide dehydrogenase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim MMS2_k127_4532380_5 748658.KB907316_gene493 8.933e-183 588.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding MMS2_k127_4532380_0 396588.Tgr7_2456 8.731e-290 897.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N MMS2_k127_4532380_6 713586.KB900536_gene1247 1.002e-176 557.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N MMS2_k127_4532380_17 519989.ECTPHS_11482 3.045e-90 305.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1WWW9@135613|Chromatiales 135613|Chromatiales L Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis rnt - - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T MMS2_k127_4532380_19 396588.Tgr7_2459 2.484e-85 292.0 COG2199@1|root,COG3706@2|Bacteria,1R76U@1224|Proteobacteria,1S15R@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg MMS2_k127_4532380_25 713587.THITH_14760 4.093e-55 194.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1WYMA@135613|Chromatiales 135613|Chromatiales O Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin MMS2_k127_4532380_13 1294143.H681_22570 3.258e-97 326.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,1RQP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator ynfL GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_4532380_9 479434.Sthe_2955 6.141e-123 402.0 COG4941@1|root,COG4941@2|Bacteria,2G84R@200795|Chloroflexi 200795|Chloroflexi K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 MMS2_k127_453999_17 1123368.AUIS01000019_gene1212 3.198e-57 201.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RMII@1236|Gammaproteobacteria,2NC3Y@225057|Acidithiobacillales 225057|Acidithiobacillales C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN MMS2_k127_453999_13 765913.ThidrDRAFT_3940 5.823e-109 370.0 COG1639@1|root,COG2199@1|root,COG1639@2|Bacteria,COG3706@2|Bacteria,1MVRF@1224|Proteobacteria,1RPH0@1236|Gammaproteobacteria,1WYQ7@135613|Chromatiales 135613|Chromatiales T HDOD domain - - - - - - - - - - - - GGDEF,HDOD MMS2_k127_453999_4 1301098.PKB_0528 2.675e-157 526.0 COG0834@1|root,COG5001@1|root,COG0834@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9,SBP_bac_3 MMS2_k127_453999_20 82996.sch_02250 2.085e-43 167.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1TAD1@1236|Gammaproteobacteria,404UV@613|Serratia 1236|Gammaproteobacteria K Domain of unknown function (DUF1956) - - - - - - - - - - - - DUF1956,TetR_N MMS2_k127_453999_15 1283300.ATXB01000001_gene1932 2.899e-87 300.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,1RP16@1236|Gammaproteobacteria,1XEYF@135618|Methylococcales 135618|Methylococcales M Biotin-lipoyl like - - - ko:K01993 - - - - ko00000 - - - HlyD_D23 MMS2_k127_453999_2 349163.Acry_1795 4.347e-215 691.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2JYV7@204441|Rhodospirillales 204441|Rhodospirillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_453999_8 1249627.D779_1081 5.361e-143 463.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1WXV1@135613|Chromatiales 135613|Chromatiales V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 MMS2_k127_453999_9 335543.Sfum_2393 1.383e-137 447.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria,2MQ4K@213462|Syntrophobacterales 28221|Deltaproteobacteria V ABC-2 family transporter protein ybhR - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 MMS2_k127_453999_11 1288826.MSNKSG1_12982 1.842e-129 419.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,464HW@72275|Alteromonadaceae 1236|Gammaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB GO:0000166,GO:0003674,GO:0005215,GO:0005315,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008144,GO:0008150,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0017076,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035303,GO:0035435,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran MMS2_k127_453999_12 1163617.SCD_n00928 1.418e-110 364.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria 28216|Betaproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 MMS2_k127_453999_10 1304275.C41B8_02182 1.685e-129 421.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0009314,GO:0009628,GO:0010921,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - ic_1306.c4652 BPD_transp_1 MMS2_k127_453999_6 1304275.C41B8_02177 1.929e-154 498.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,1RN5Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - iECH74115_1262.ECH74115_5157,iECSP_1301.ECSP_4770,iECs_1301.ECs4664,iG2583_1286.G2583_4518,iJN746.PP_2656,iZ_1308.Z5219 PBP_like_2 MMS2_k127_453999_1 765913.ThidrDRAFT_0469 4.564e-271 856.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel MMS2_k127_453999_19 1396858.Q666_04845 1.188e-45 183.0 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,1S5YR@1236|Gammaproteobacteria,467C1@72275|Alteromonadaceae 1236|Gammaproteobacteria O protein conserved in archaea - - - - - - - - - - - - Zn_protease MMS2_k127_453999_5 396588.Tgr7_0449 1.251e-155 498.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1WX7Z@135613|Chromatiales 135613|Chromatiales HJ Belongs to the RimK family rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK MMS2_k127_453999_16 1288826.MSNKSG1_14177 8.568e-84 289.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,464S0@72275|Alteromonadaceae 1236|Gammaproteobacteria P CorA-like Mg2+ transporter protein zntB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA MMS2_k127_453999_21 1283300.ATXB01000001_gene2310 2.747e-31 128.0 COG3431@1|root,COG3431@2|Bacteria,1N4JH@1224|Proteobacteria,1T11Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE MMS2_k127_453999_3 1266909.AUAG01000003_gene794 1.234e-208 669.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt MMS2_k127_453999_22 713586.KB900536_gene275 9.952e-24 102.0 COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,1SCRA@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0607 Rhodanese-related sulfurtransferase - - - - - - - - - - - - DUF2892 MMS2_k127_453999_14 555778.Hneap_0297 2.014e-92 308.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,1WXRU@135613|Chromatiales 135613|Chromatiales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B MMS2_k127_453999_18 637389.Acaty_c2446 3.247e-46 173.0 COG1416@1|root,COG1416@2|Bacteria,1NBIB@1224|Proteobacteria,1SZPQ@1236|Gammaproteobacteria,2NCZZ@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_453999_7 1223521.BBJX01000002_gene2671 1.127e-151 492.0 COG0446@1|root,COG0446@2|Bacteria,1QA17@1224|Proteobacteria,2VICY@28216|Betaproteobacteria,4AD86@80864|Comamonadaceae 28216|Betaproteobacteria S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 MMS2_k127_453999_0 765914.ThisiDRAFT_1392 5.742e-292 907.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,1WX2I@135613|Chromatiales 135613|Chromatiales J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C MMS2_k127_4555028_10 1304275.C41B8_03421 3.875e-121 399.0 COG1018@1|root,COG1018@2|Bacteria,1MU6E@1224|Proteobacteria,1RNA4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Flavodoxin reductases (Ferredoxin-NADPH reductases) family 1 yeaX - 1.14.13.238,1.14.13.239 ko:K07006,ko:K22343,ko:K22444 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1,Putative_PNPOx MMS2_k127_4555028_16 1121033.AUCF01000003_gene3041 2.416e-80 276.0 COG1802@1|root,COG1802@2|Bacteria,1NWSI@1224|Proteobacteria,2TTXQ@28211|Alphaproteobacteria,2JWHU@204441|Rhodospirillales 204441|Rhodospirillales K FCD - - - - - - - - - - - - FCD,GntR MMS2_k127_4555028_0 1304275.C41B8_03411 1.943e-188 595.0 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria,1RQ8W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit vanA - 1.14.13.82 ko:K03862 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001,ko01000 - - - Rieske MMS2_k127_4555028_6 1121033.AUCF01000026_gene2979 8.95e-154 497.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,2JS33@204441|Rhodospirillales 204441|Rhodospirillales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 MMS2_k127_4555028_2 1232683.ADIMK_0088 2.257e-169 541.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,464AI@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria galD GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF MMS2_k127_4555028_12 1082931.KKY_3764 6.114e-110 374.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase ligK - 4.1.3.17 ko:K02553,ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000,ko03019 - - - RraA-like MMS2_k127_4555028_7 391937.NA2_00820 2.767e-137 439.0 COG2120@1|root,COG2120@2|Bacteria,1MUTM@1224|Proteobacteria,2TSJ8@28211|Alphaproteobacteria,43J4Z@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S GlcNAc-PI de-N-acetylase MA20_26640 - 4.2.1.83 ko:K16515 ko00362,map00362 - R04478 RC00498 ko00000,ko00001,ko01000 - - - PIG-L MMS2_k127_4555028_14 1121033.AUCF01000026_gene2984 2.701e-97 326.0 COG2084@1|root,COG3384@1|root,COG2084@2|Bacteria,COG3384@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,2JTAE@204441|Rhodospirillales 204441|Rhodospirillales I Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,NAD_binding_2 MMS2_k127_4555028_17 1121033.AUCF01000026_gene2984 2.564e-56 199.0 COG2084@1|root,COG3384@1|root,COG2084@2|Bacteria,COG3384@2|Bacteria,1MX8V@1224|Proteobacteria,2TVBS@28211|Alphaproteobacteria,2JTAE@204441|Rhodospirillales 204441|Rhodospirillales I Domain of unknown function (DUF1932) - - - - - - - - - - - - DUF1932,NAD_binding_2 MMS2_k127_4555028_4 1121033.AUCF01000026_gene2985 7.796e-158 501.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2JVBN@204441|Rhodospirillales 204441|Rhodospirillales S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - - - - - - - - - - LigA,LigB MMS2_k127_4555028_3 1232683.ADIMK_0092 5.382e-161 513.0 COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,1RP9K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S dehydrogenases and related proteins ligC - 1.1.1.312 ko:K10219 ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220 M00533 R04278,R04279,R04418,R04419 RC00251,RC00254 ko00000,ko00001,ko00002,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C MMS2_k127_4555028_8 1382303.JPOM01000001_gene2331 1.382e-125 423.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,2KFMY@204458|Caulobacterales 204458|Caulobacterales C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red MMS2_k127_4555028_5 1196029.ALIM01000023_gene620 2.776e-156 503.0 COG0654@1|root,COG0654@2|Bacteria,1TSDI@1239|Firmicutes,4HDY7@91061|Bacilli,1ZEHZ@1386|Bacillus 91061|Bacilli CH FAD binding domain - - 1.14.13.2 ko:K00481 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R01298 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 MMS2_k127_4555028_1 935548.KI912159_gene5790 5.798e-180 572.0 COG0683@1|root,COG0683@2|Bacteria,1N0MT@1224|Proteobacteria,2TUMI@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC transporter substrate-binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS2_k127_4555028_13 1380350.JIAP01000002_gene4291 1.516e-99 334.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U1PV@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C MMS2_k127_4555028_15 491916.RHECIAT_PC0000928 1.227e-93 316.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2U1ZT@28211|Alphaproteobacteria,4BBS7@82115|Rhizobiaceae 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran MMS2_k127_4555028_11 935548.KI912159_gene5787 9.936e-118 389.0 COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2TUJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_4555028_9 395492.Rleg2_4886 1.065e-122 408.0 COG4177@1|root,COG4177@2|Bacteria,1NY9G@1224|Proteobacteria,2U2B5@28211|Alphaproteobacteria,4BBPP@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 MMS2_k127_4603659_6 396588.Tgr7_2752 2.048e-105 349.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,1RQIA@1236|Gammaproteobacteria,1WWVB@135613|Chromatiales 135613|Chromatiales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 MMS2_k127_4603659_11 396588.Tgr7_2693 4.432e-62 221.0 2AEMZ@1|root,314HW@2|Bacteria,1RHE3@1224|Proteobacteria,1S7P7@1236|Gammaproteobacteria,1WYF1@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_4603659_16 396588.Tgr7_2692 3.834e-36 149.0 28RJX@1|root,2ZDYR@2|Bacteria,1P4WE@1224|Proteobacteria,1SU5T@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4603659_19 1123401.JHYQ01000008_gene395 5.651e-18 87.0 COG5007@1|root,COG5007@2|Bacteria,1R3MK@1224|Proteobacteria,1SE4M@1236|Gammaproteobacteria,461DD@72273|Thiotrichales 72273|Thiotrichales K Belongs to the BolA IbaG family - - - - - - - - - - - - BolA MMS2_k127_4603659_18 396588.Tgr7_2687 1.039e-23 113.0 2E6K1@1|root,3316U@2|Bacteria,1NCHT@1224|Proteobacteria,1S72Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4603659_13 396588.Tgr7_2686 3.636e-51 188.0 COG0664@1|root,COG0664@2|Bacteria,1N1ZG@1224|Proteobacteria,1SA1H@1236|Gammaproteobacteria,1X12H@135613|Chromatiales 135613|Chromatiales T Cyclic nucleotide-binding domain - - - - - - - - - - - - cNMP_binding MMS2_k127_4603659_9 572477.Alvin_0012 1.074e-91 319.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1RPMH@1236|Gammaproteobacteria,1WXSN@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - HATPase_c MMS2_k127_4603659_8 472759.Nhal_0478 7.123e-92 306.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1S0IN@1236|Gammaproteobacteria,1X2DH@135613|Chromatiales 135613|Chromatiales K PFAM response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C MMS2_k127_4603659_20 1114970.PSF113_1878 4.552e-06 54.0 COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,1SH2G@1236|Gammaproteobacteria,1YQW8@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Peptidase propeptide and YPEB domain - - - - - - - - - - - - PepSY MMS2_k127_4603659_4 519989.ECTPHS_09233 2.78e-124 414.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales 135613|Chromatiales J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC MMS2_k127_4603659_14 396588.Tgr7_0510 3.049e-41 156.0 COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,1S8SI@1236|Gammaproteobacteria,1WYYF@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1244) - - - ko:K09948 - - - - ko00000 - - - DUF1244 MMS2_k127_4603659_12 519989.ECTPHS_09243 2.304e-55 207.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD MMS2_k127_4603659_10 765914.ThisiDRAFT_1912 5.376e-70 247.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales 135613|Chromatiales M Involved in formation and maintenance of cell shape - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC MMS2_k127_4603659_2 396588.Tgr7_0514 1.873e-189 598.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1WW91@135613|Chromatiales 135613|Chromatiales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl MMS2_k127_4603659_17 1286106.MPL1_05384 2.33e-30 124.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,4618D@72273|Thiotrichales 72273|Thiotrichales H Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln MMS2_k127_4603659_1 396588.Tgr7_0516 5.039e-245 766.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase MMS2_k127_4603659_0 396588.Tgr7_0517 3.863e-262 812.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey MMS2_k127_4603659_5 396588.Tgr7_0518 4.017e-110 365.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales 135613|Chromatiales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 MMS2_k127_4603659_3 518766.Rmar_0511 2.356e-133 437.0 COG2133@1|root,COG2133@2|Bacteria,4NDV1@976|Bacteroidetes 976|Bacteroidetes G Glucose Sorbosone dehydrogenase - - - - - - - - - - - - GSDH MMS2_k127_4603659_7 555778.Hneap_1015 8.114e-103 343.0 COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,1T1Q3@1236|Gammaproteobacteria,1WXCI@135613|Chromatiales 135613|Chromatiales P PFAM periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA MMS2_k127_4603659_15 555778.Hneap_1014 9.053e-41 155.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1WXP4@135613|Chromatiales 135613|Chromatiales P ABC transporter znuC - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran MMS2_k127_4610795_0 396588.Tgr7_1535 6.89e-295 914.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV MMS2_k127_4610795_1 349124.Hhal_0570 3.659e-145 469.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 MMS2_k127_4630356_2 396595.TK90_0480 2.948e-95 321.0 COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,1RRD5@1236|Gammaproteobacteria,1WW42@135613|Chromatiales 135613|Chromatiales IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C MMS2_k127_4630356_4 1151127.KB906325_gene4426 1.192e-53 200.0 COG0697@1|root,COG0697@2|Bacteria,1R6XT@1224|Proteobacteria,1RU2S@1236|Gammaproteobacteria,1YNFF@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_4630356_1 379731.PST_4007 1.767e-112 368.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1Z02Q@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS MMS2_k127_4630356_5 748658.KB907312_gene1619 2.938e-41 153.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,1WYW0@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein fdx - - - - - - - - - - - Fer4 MMS2_k127_4630356_3 765914.ThisiDRAFT_0059 1.301e-63 222.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales 135613|Chromatiales H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like MMS2_k127_4630356_0 1288826.MSNKSG1_07993 9.309e-117 381.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,464FM@72275|Alteromonadaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg MMS2_k127_4657855_4 1232683.ADIMK_3079 4.596e-30 139.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,469HJ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco MMS2_k127_4657855_2 713586.KB900536_gene2406 1.123e-51 189.0 COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Sporulation related domain - - - - - - - - - - - - SPOR MMS2_k127_4657855_0 713586.KB900536_gene2407 2.759e-276 859.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d MMS2_k127_4657855_3 1123401.JHYQ01000013_gene673 2.528e-36 145.0 COG4902@1|root,COG4902@2|Bacteria,1RHUF@1224|Proteobacteria,1S5D0@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein domain (DUF2202) - - - - - - - - - - - - DUF2202 MMS2_k127_4657855_1 187272.Mlg_2496 2.092e-243 772.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII MMS2_k127_4667824_4 1123229.AUBC01000004_gene3275 5.459e-74 254.0 COG2186@1|root,COG2186@2|Bacteria,1MXN5@1224|Proteobacteria,2U1II@28211|Alphaproteobacteria,3JVTS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K FCD - - - - - - - - - - - - FCD,GntR MMS2_k127_4667824_2 388401.RB2150_05993 1.91e-88 318.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3ZG8E@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_3 MMS2_k127_4667824_5 1338011.BD94_2079 3.538e-05 47.0 29ZAT@1|root,30M96@2|Bacteria,4PA2X@976|Bacteroidetes,1IGVJ@117743|Flavobacteriia,34SDH@308865|Elizabethkingia 976|Bacteroidetes - - - - - - - - - - - - - - - MMS2_k127_4667824_1 240292.Ava_4981 2.055e-109 360.0 COG0678@1|root,COG0695@1|root,COG0678@2|Bacteria,COG0695@2|Bacteria,1G1CH@1117|Cyanobacteria,1HMHQ@1161|Nostocales 1117|Cyanobacteria O TIGRFAM Glutaredoxin-family domain - GO:0003674,GO:0005488,GO:0005515,GO:0042802 - - - - - - - - - - Glutaredoxin,Redoxin MMS2_k127_4667824_0 765913.ThidrDRAFT_2963 2.781e-203 647.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,1WVV8@135613|Chromatiales 135613|Chromatiales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim MMS2_k127_4667824_3 1500301.JQMF01000009_gene1264 5.169e-78 266.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2TQWG@28211|Alphaproteobacteria,4BCKN@82115|Rhizobiaceae 28211|Alphaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE MMS2_k127_4676544_1 713587.THITH_10615 4.229e-51 189.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales 135613|Chromatiales K PFAM Cyclic nucleotide-binding - - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding MMS2_k127_4676544_0 1123368.AUIS01000032_gene1408 1.926e-68 245.0 COG2259@1|root,COG2259@2|Bacteria,1R708@1224|Proteobacteria,1SQK9@1236|Gammaproteobacteria,2NC2B@225057|Acidithiobacillales 225057|Acidithiobacillales S PFAM TQO small subunit DoxD - - 1.8.5.2 ko:K16936,ko:K16937 ko00920,ko01120,map00920,map01120 - R07177 - ko00000,ko00001,ko01000 3.D.4.9 - - DoxA,DoxD MMS2_k127_4682265_1 396588.Tgr7_1372 7.956e-92 312.0 2CCMG@1|root,33UCX@2|Bacteria,1NUGG@1224|Proteobacteria,1SNT7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Glycos_transf_N MMS2_k127_4682265_0 396588.Tgr7_1371 8.256e-170 544.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales 135613|Chromatiales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran MMS2_k127_4683412_22 1453496.AT03_18855 2.657e-56 198.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 MMS2_k127_4683412_20 1123400.KB904813_gene3118 6e-71 244.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,460KF@72273|Thiotrichales 72273|Thiotrichales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 MMS2_k127_4683412_25 396588.Tgr7_2790 2.034e-40 156.0 COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,1WYUE@135613|Chromatiales 135613|Chromatiales C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx MMS2_k127_4683412_13 472759.Nhal_0846 2.473e-101 344.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WWXD@135613|Chromatiales 135613|Chromatiales C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 MMS2_k127_4683412_18 1123399.AQVE01000010_gene3293 5.95e-73 267.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,460NH@72273|Thiotrichales 72273|Thiotrichales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 MMS2_k127_4683412_7 314278.NB231_07492 5.569e-150 501.0 COG1444@1|root,COG1444@2|Bacteria,1NBA4@1224|Proteobacteria,1RPAM@1236|Gammaproteobacteria,1WWJD@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) tmcA - 2.3.1.193 ko:K06957 - - - - ko00000,ko01000,ko03016 - - - DUF1726,GNAT_acetyltr_2,Helicase_RecD,tRNA_bind_3 MMS2_k127_4683412_21 519989.ECTPHS_11707 1.667e-67 233.0 COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1WZ4B@135613|Chromatiales 135613|Chromatiales K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length greB - - ko:K04760 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N MMS2_k127_4683412_9 1408418.JNJH01000071_gene2482 1.102e-124 409.0 COG1275@1|root,COG1275@2|Bacteria,1MXP2@1224|Proteobacteria,2TRB9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P C4-dicarboxylate transporter malic acid transport protein - - - - - - - - - - - - SLAC1 MMS2_k127_4683412_19 477184.KYC_06425 3.713e-72 253.0 COG0583@1|root,COG0583@2|Bacteria,1R9GY@1224|Proteobacteria,2VHIQ@28216|Betaproteobacteria,3T6ZX@506|Alcaligenaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_4683412_24 1121937.AUHJ01000008_gene2008 3.788e-42 165.0 COG3658@1|root,COG3658@2|Bacteria,1PCRS@1224|Proteobacteria,1S5C0@1236|Gammaproteobacteria,46AVI@72275|Alteromonadaceae 1236|Gammaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB MMS2_k127_4683412_4 1123392.AQWL01000010_gene2312 1.973e-165 529.0 COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,2WGR7@28216|Betaproteobacteria,1KSBE@119069|Hydrogenophilales 119069|Hydrogenophilales G Sugar (and other) transporter - - - - - - - - - - - - MFS_1 MMS2_k127_4683412_23 743299.Acife_1005 4.119e-49 187.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,1RSEU@1236|Gammaproteobacteria,2NDCA@225057|Acidithiobacillales 225057|Acidithiobacillales G Belongs to the phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 MMS2_k127_4683412_11 743299.Acife_0999 8.418e-108 383.0 COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,1S4W5@1236|Gammaproteobacteria,2NDNC@225057|Acidithiobacillales 225057|Acidithiobacillales S Glycosyl transferase family 1 - - - - - - - - - - - - Glyco_tran_28_C MMS2_k127_4683412_0 743299.Acife_1002 3.367e-232 732.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,2NC3G@225057|Acidithiobacillales 225057|Acidithiobacillales P ABC transporter, transmembrane region - - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran MMS2_k127_4683412_8 743299.Acife_1001 2.114e-131 440.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RYBJ@1236|Gammaproteobacteria,2NDM4@225057|Acidithiobacillales 225057|Acidithiobacillales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 MMS2_k127_4683412_6 380394.Lferr_0766 2.929e-161 517.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,1RQ8J@1236|Gammaproteobacteria,2NDHR@225057|Acidithiobacillales 225057|Acidithiobacillales M glycosyl transferase group 1 - - - - - - - - - - - - Glycos_transf_1 MMS2_k127_4683412_1 396588.Tgr7_0530 2.905e-188 592.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales 135613|Chromatiales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C MMS2_k127_4683412_16 396588.Tgr7_0529 1.235e-78 266.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales 135613|Chromatiales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro MMS2_k127_4683412_17 713586.KB900536_gene1581 1.865e-75 259.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1WYEN@135613|Chromatiales 135613|Chromatiales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C MMS2_k127_4683412_2 765914.ThisiDRAFT_0700 5.142e-166 526.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales 135613|Chromatiales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N MMS2_k127_4683412_12 396588.Tgr7_0526 6.352e-103 342.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales 135613|Chromatiales I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N MMS2_k127_4683412_26 105559.Nwat_2578 8.809e-37 147.0 COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,1WZK9@135613|Chromatiales 135613|Chromatiales M Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein lolB - - ko:K02494 - - - - ko00000 - - - LolB MMS2_k127_4683412_10 519989.ECTPHS_02461 1.901e-110 378.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales 135613|Chromatiales U Tetratricopeptide TPR_2 repeat protein - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 MMS2_k127_4683412_5 396588.Tgr7_0523 1.588e-162 522.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH MMS2_k127_4683412_3 870187.Thini_1102 1.635e-165 532.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,4604F@72273|Thiotrichales 72273|Thiotrichales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 MMS2_k127_4683412_14 1385515.N791_02130 7.414e-94 317.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales 135614|Xanthomonadales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 MMS2_k127_4683412_15 1209072.ALBT01000023_gene4077 1.093e-92 325.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1FGQ2@10|Cellvibrio 1236|Gammaproteobacteria H ThiF family moeB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0061605,GO:0070566,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - iECIAI1_1343.ECIAI1_0865,iECW_1372.ECW_m0884,iEKO11_1354.EKO11_3059,iETEC_1333.ETEC_0893,iEcE24377_1341.EcE24377A_0897,iEcSMS35_1347.EcSMS35_0851,iWFL_1372.ECW_m0884 ThiF MMS2_k127_4683412_27 134676.ACPL_2939 1.852e-31 134.0 COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria,4DD1M@85008|Micromonosporales 201174|Actinobacteria G phosphoglycerate mutase - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 MMS2_k127_4717914_23 686340.Metal_1067 4.667e-27 113.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,1RPRD@1236|Gammaproteobacteria,1XEDZ@135618|Methylococcales 135618|Methylococcales C alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 MMS2_k127_4717914_27 309807.SRU_2389 1.761e-06 53.0 COG1833@1|root,COG1833@2|Bacteria,4PF8V@976|Bacteroidetes,1FKAW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Domain of unknown function DUF123 - - - - - - - - - - - - DUF123 MMS2_k127_4717914_25 1304888.ATWF01000001_gene1808 8.15e-19 91.0 COG1833@1|root,COG1833@2|Bacteria,2GGIN@200930|Deferribacteres 200930|Deferribacteres S Domain of unknown function DUF123 - - - - - - - - - - - - DUF123 MMS2_k127_4717914_13 1082931.KKY_234 3.132e-98 335.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,3N64Y@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria E ABC transporter glnQ - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran MMS2_k127_4717914_16 439375.Oant_3463 1.27e-83 284.0 COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,2TUMA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC transporter (Permease) - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 MMS2_k127_4717914_20 1007105.PT7_1537 5.475e-68 238.0 COG0765@1|root,COG0765@2|Bacteria,1R3X2@1224|Proteobacteria,2W1TR@28216|Betaproteobacteria,3T27W@506|Alcaligenaceae 28216|Betaproteobacteria E ABC transporter permease ehuC - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 MMS2_k127_4717914_18 439375.Oant_3465 4.786e-80 276.0 COG0834@1|root,COG0834@2|Bacteria,1R26Z@1224|Proteobacteria,2VEUM@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 MMS2_k127_4717914_22 1238182.C882_3809 1.224e-47 176.0 COG1522@1|root,COG1522@2|Bacteria,1RH5M@1224|Proteobacteria,2UAXN@28211|Alphaproteobacteria,2JT4K@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix ASNC type - - - ko:K15782 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24 MMS2_k127_4717914_15 1089552.KI911559_gene746 1.022e-85 294.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2TSVB@28211|Alphaproteobacteria,2JQWH@204441|Rhodospirillales 204441|Rhodospirillales S Succinylglutamate desuccinylase / Aspartoacylase family - - 3.5.1.125 ko:K15784 ko00260,ko01100,map00260,map01100 - R09801 RC00064,RC00300 ko00000,ko00001,ko01000 - - - AstE_AspA MMS2_k127_4717914_4 1123366.TH3_03494 7.558e-186 595.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPIJ@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - - ko:K15786 ko00260,map00260 - R09805 RC00080 ko00000,ko00001,ko01000 - - - Aldedh MMS2_k127_4717914_3 570952.ATVH01000018_gene3259 7.793e-197 625.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JQ6R@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.76 ko:K15785 ko00260,map00260 - R06977 RC00006,RC00062 ko00000,ko00001,ko01000 - - - Aminotran_3 MMS2_k127_4717914_12 1232683.ADIMK_2313 1.139e-98 331.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,46556@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA eutB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP MMS2_k127_4717914_10 1547437.LL06_04580 4.057e-103 347.0 COG2423@1|root,COG2423@2|Bacteria,1N3EI@1224|Proteobacteria,2TT7X@28211|Alphaproteobacteria,43HEM@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Ectoine utilization protein EutC eutC - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall MMS2_k127_4717914_6 1238182.C882_3814 6.839e-148 480.0 COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,2TT29@28211|Alphaproteobacteria,2JRC0@204441|Rhodospirillales 204441|Rhodospirillales E Creatinase/Prolidase N-terminal domain - - - - - - - - - - - - Creatinase_N,Peptidase_M24 MMS2_k127_4717914_19 1123393.KB891316_gene1482 7.793e-75 258.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VQMN@28216|Betaproteobacteria,1KSHY@119069|Hydrogenophilales 119069|Hydrogenophilales O 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM MMS2_k127_4717914_26 243160.BMA0628 1.87e-17 90.0 COG1328@1|root,COG1328@2|Bacteria,1N8MB@1224|Proteobacteria,2VW43@28216|Betaproteobacteria,1KB6N@119060|Burkholderiaceae 28216|Betaproteobacteria F Anaerobic ribonucleoside-triphosphate reductase - - - - - - - - - - - - NRDD MMS2_k127_4717914_0 232721.Ajs_0087 0.0 1162.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,2VJYM@28216|Betaproteobacteria,4ABIQ@80864|Comamonadaceae 28216|Betaproteobacteria F Ribonucleoside-triphosphate reductase nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD MMS2_k127_4717914_11 518766.Rmar_0188 1.072e-99 344.0 COG2897@1|root,COG2897@2|Bacteria,4NF85@976|Bacteroidetes 976|Bacteroidetes P sulfurtransferase sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese MMS2_k127_4717914_14 322710.Avin_44940 1.872e-94 316.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033744,GO:0036456,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114,GO:0071704,GO:1901564 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - iECSE_1348.ECSE_4525 PMSR MMS2_k127_4717914_17 323261.Noc_1572 1.629e-81 282.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RZYT@1236|Gammaproteobacteria,1WY5J@135613|Chromatiales 135613|Chromatiales O Peptidase M48 - - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 MMS2_k127_4717914_24 243233.MCA0583 3.286e-22 109.0 COG0517@1|root,COG0517@2|Bacteria,1QJRF@1224|Proteobacteria,1THSQ@1236|Gammaproteobacteria,1XFJQ@135618|Methylococcales 135618|Methylococcales S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS MMS2_k127_4717914_5 768671.ThimaDRAFT_3445 3.084e-152 490.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RSHP@1236|Gammaproteobacteria,1WWZP@135613|Chromatiales 135613|Chromatiales G peptidase M42 - - - - - - - - - - - - Peptidase_M42 MMS2_k127_4717914_8 1178482.BJB45_00605 1.075e-129 437.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia - - 3.5.3.9 ko:K02083 ko00230,ko01120,map00230,map01120 - R02423 RC00064 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 MMS2_k127_4717914_21 1123228.AUIH01000047_gene409 1.176e-53 196.0 COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,1RYZ6@1236|Gammaproteobacteria,1XPJE@135619|Oceanospirillales 135619|Oceanospirillales S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028 MMS2_k127_4717914_2 1122214.AQWH01000003_gene4089 3.877e-238 746.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,2PKJ9@255475|Aurantimonadaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS2_k127_4717914_7 1547437.LL06_23005 4.661e-146 470.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,43JT9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS2_k127_4717914_1 1528106.JRJE01000020_gene2224 6.688e-259 829.0 COG0444@1|root,COG1173@1|root,COG0444@2|Bacteria,COG1173@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JPT1@204441|Rhodospirillales 204441|Rhodospirillales EP Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY MMS2_k127_4717914_9 388399.SSE37_20462 3.315e-118 417.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS2_k127_4734943_6 1338011.BD94_2125 0.0001177 51.0 COG0457@1|root,COG2976@1|root,COG4105@1|root,COG0457@2|Bacteria,COG2976@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,1HX2D@117743|Flavobacteriia,34PHG@308865|Elizabethkingia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_2,TPR_21,TPR_6,TPR_8 MMS2_k127_4734943_5 283942.IL1855 7.182e-22 104.0 COG0810@1|root,COG0810@2|Bacteria,1R4VE@1224|Proteobacteria,1RQPV@1236|Gammaproteobacteria,2QFD6@267893|Idiomarinaceae 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB2 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C MMS2_k127_4734943_3 1415779.JOMH01000001_gene337 3.118e-29 121.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1X7VH@135614|Xanthomonadales 135614|Xanthomonadales U Biopolymer transport protein ExbD/TolR - - - - - - - - - - - - ExbD MMS2_k127_4734943_4 382464.ABSI01000010_gene3463 1.657e-22 102.0 COG0848@1|root,COG0848@2|Bacteria 2|Bacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD MMS2_k127_4734943_2 105559.Nwat_2487 7.614e-39 156.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria,1X15P@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB MMS2_k127_4734943_0 745411.B3C1_16310 5.618e-107 362.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1J4VD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel family protein - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB MMS2_k127_4734943_1 414684.RC1_0799 7.941e-53 196.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,2UA8C@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 MMS2_k127_4753297_1 713586.KB900536_gene2219 9.747e-106 352.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1X2ES@135613|Chromatiales 135613|Chromatiales M Bacterial lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans MMS2_k127_4753297_0 998674.ATTE01000001_gene3455 1.834e-128 415.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,45ZYE@72273|Thiotrichales 72273|Thiotrichales D Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 MMS2_k127_4782726_6 768671.ThimaDRAFT_3258 4.51e-37 144.0 COG2258@1|root,COG2258@2|Bacteria,1PVVI@1224|Proteobacteria,1SB64@1236|Gammaproteobacteria,1X0QQ@135613|Chromatiales 135613|Chromatiales S MOSC domain - - - - - - - - - - - - MOSC MMS2_k127_4782726_4 349163.Acry_1227 1.026e-47 181.0 COG1280@1|root,COG1280@2|Bacteria,1MX0K@1224|Proteobacteria,2U7BW@28211|Alphaproteobacteria,2JZED@204441|Rhodospirillales 204441|Rhodospirillales E LysE type translocator - - - - - - - - - - - - LysE MMS2_k127_4782726_1 666685.R2APBS1_3519 2.967e-74 254.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,1X6UB@135614|Xanthomonadales 135614|Xanthomonadales S NnrU protein - - - - - - - - - - - - NnrU MMS2_k127_4782726_0 187272.Mlg_1123 2.533e-152 488.0 COG3654@1|root,COG3943@1|root,COG3654@2|Bacteria,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,1RPNB@1236|Gammaproteobacteria,1WZ38@135613|Chromatiales 135613|Chromatiales S Virulence protein RhuM family - - - - - - - - - - - - Fic,Virulence_RhuM MMS2_k127_4782726_2 338969.Rfer_0025 4.727e-74 256.0 COG4849@1|root,COG4849@2|Bacteria,1RDHG@1224|Proteobacteria,2VVB8@28216|Betaproteobacteria,4AF0B@80864|Comamonadaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - MMS2_k127_4782726_7 338969.Rfer_0026 1.587e-35 141.0 28W7P@1|root,2ZI89@2|Bacteria,1N2SJ@1224|Proteobacteria,2VX5G@28216|Betaproteobacteria,4AFQ3@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4782726_5 765913.ThidrDRAFT_1130 3.991e-40 162.0 COG0551@1|root,COG0551@2|Bacteria,1PZFI@1224|Proteobacteria,1RQ64@1236|Gammaproteobacteria,1WXVE@135613|Chromatiales 135613|Chromatiales L NERD domain protein - - - - - - - - - - - - NERD,zf-C4_Topoisom MMS2_k127_4782726_3 159087.Daro_1440 7.471e-73 251.0 COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2VJY3@28216|Betaproteobacteria 28216|Betaproteobacteria E abc-type branched-chain amino acid transport - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6,TAT_signal MMS2_k127_4849718_1 1322246.BN4_11803 1.678e-101 352.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,42KZX@68525|delta/epsilon subdivisions,2X5GJ@28221|Deltaproteobacteria,2MGA5@213115|Desulfovibrionales 28221|Deltaproteobacteria S KR domain - - - - - - - - - - - - adh_short MMS2_k127_4849718_3 319225.Plut_0661 1.631e-40 159.0 COG1451@1|root,COG1451@2|Bacteria,1FE2Z@1090|Chlorobi 1090|Chlorobi S WLM domain - - - ko:K07043 - - - - ko00000 - - - DUF45 MMS2_k127_4849718_4 1097668.BYI23_A005360 7.088e-24 108.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1K9CX@119060|Burkholderiaceae 28216|Betaproteobacteria K Cold shock protein cspD - - ko:K03704 - - - - ko00000,ko03000 - - - CSD MMS2_k127_4849718_0 637389.Acaty_c1947 2.519e-126 421.0 COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,1S093@1236|Gammaproteobacteria,2NC6Z@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase MMS2_k127_4849718_2 396588.Tgr7_1946 3.24e-68 247.0 COG1917@1|root,COG1917@2|Bacteria,1QU6U@1224|Proteobacteria,1T1P4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Anti-ECFsigma factor ChrR - - - - - - - - - - - - Cupin_7 MMS2_k127_4855089_3 396588.Tgr7_1284 2.448e-11 68.0 2A7N8@1|root,30WK9@2|Bacteria,1QSI4@1224|Proteobacteria,1SX3K@1236|Gammaproteobacteria,1X1QK@135613|Chromatiales 135613|Chromatiales S PFAM Type IV pilus assembly PilZ - - - - - - - - - - - - PilZ MMS2_k127_4855089_0 265072.Mfla_1183 2.265e-205 662.0 COG2204@1|root,COG5001@1|root,COG2204@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KM09@206350|Nitrosomonadales 206350|Nitrosomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,Response_reg MMS2_k127_4855089_1 686340.Metal_3491 2.582e-106 371.0 COG1639@1|root,COG3852@1|root,COG1639@2|Bacteria,COG3852@2|Bacteria,1R444@1224|Proteobacteria,1RYHZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF,GAF_3,HATPase_c,HDOD MMS2_k127_4855089_2 1177928.TH2_06668 1.141e-47 176.0 COG0589@1|root,COG0589@2|Bacteria,1RI97@1224|Proteobacteria,2UABJ@28211|Alphaproteobacteria,2JSV0@204441|Rhodospirillales 204441|Rhodospirillales T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp MMS2_k127_4855089_4 1122212.AULO01000011_gene541 2.781e-11 64.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,1XHEU@135619|Oceanospirillales 135619|Oceanospirillales S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DUF3394,DctM MMS2_k127_4878127_10 1246459.KB898377_gene2318 3.051e-44 167.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2UVV2@28211|Alphaproteobacteria,4BCFP@82115|Rhizobiaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate MMS2_k127_4878127_13 1140.Synpcc7942_1859 3.02e-12 68.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1GYX2@1129|Synechococcus 1117|Cyanobacteria T diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg MMS2_k127_4878127_3 187272.Mlg_0291 8.341e-107 353.0 COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,1WWDF@135613|Chromatiales 135613|Chromatiales S ATPase (AAA superfamily) - - - ko:K06923 - - - - ko00000 - - - DUF815 MMS2_k127_4878127_4 743299.Acife_1467 2.149e-73 260.0 COG1502@1|root,COG1502@2|Bacteria,1R9I4@1224|Proteobacteria,1RZ86@1236|Gammaproteobacteria,2NC1C@225057|Acidithiobacillales 225057|Acidithiobacillales I PLD-like domain - - - - - - - - - - - - PLDc_2 MMS2_k127_4878127_5 748247.AZKH_3403 4.202e-72 255.0 COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VPAG@28216|Betaproteobacteria,2KW5W@206389|Rhodocyclales 206389|Rhodocyclales EG EamA-like transporter family - - - - - - - - - - - - EamA MMS2_k127_4878127_7 1463841.JOIR01000022_gene3323 2.787e-63 239.0 COG1011@1|root,COG1011@2|Bacteria,2IHVB@201174|Actinobacteria 201174|Actinobacteria S haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase MMS2_k127_4878127_15 644968.DFW101_1969 8.791e-05 55.0 COG5339@1|root,COG5339@2|Bacteria,1Q3BQ@1224|Proteobacteria,42X2F@68525|delta/epsilon subdivisions,2WT9G@28221|Deltaproteobacteria,2ME2D@213115|Desulfovibrionales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF945) - - - - - - - - - - - - DUF945 MMS2_k127_4878127_2 483219.LILAB_12630 6.397e-119 393.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,42Q9D@68525|delta/epsilon subdivisions,2WK21@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 MMS2_k127_4878127_0 215803.DB30_3093 1.159e-164 556.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2YZE4@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD MMS2_k127_4878127_6 243231.GSU2188 1.117e-71 250.0 COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,42RPV@68525|delta/epsilon subdivisions,2WNQC@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran MMS2_k127_4878127_8 765912.Thimo_0453 4.862e-57 201.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 MMS2_k127_4878127_1 472759.Nhal_2571 2.692e-149 482.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RZ4V@1236|Gammaproteobacteria,1WW06@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 MMS2_k127_4878127_9 32057.KB217478_gene1920 1.348e-52 210.0 COG1289@1|root,COG1289@2|Bacteria,1G1H2@1117|Cyanobacteria,1HRXQ@1161|Nostocales 1117|Cyanobacteria S FUSC-like inner membrane protein yccS - - - - - - - - - - - - FUSC-like,FUSC_2 MMS2_k127_4878127_11 1122185.N792_00130 3.307e-38 145.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria,1X3K1@135614|Xanthomonadales 135614|Xanthomonadales L DNA repair photolyase - - - - - - - - - - - - Radical_SAM MMS2_k127_4897621_3 1266909.AUAG01000010_gene2615 1.701e-53 189.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1WYFA@135613|Chromatiales 135613|Chromatiales P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC MMS2_k127_4897621_1 1163617.SCD_n02712 6.865e-92 308.0 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,2VPFB@28216|Betaproteobacteria 28216|Betaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - Nitrate_red_gam MMS2_k127_4897621_0 713586.KB900536_gene1018 5.908e-260 809.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 MMS2_k127_4897621_2 713587.THITH_12020 1.781e-66 229.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2 MMS2_k127_4898513_3 713586.KB900536_gene1079 1.339e-151 488.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1WWGF@135613|Chromatiales 135613|Chromatiales F PFAM AIR synthase related protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C MMS2_k127_4898513_5 396588.Tgr7_2254 2.357e-72 260.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales 135613|Chromatiales F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N MMS2_k127_4898513_10 1123400.KB904746_gene1345 1.167e-10 74.0 2BJ82@1|root,32DHI@2|Bacteria,1RHVJ@1224|Proteobacteria,1S6YB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 MMS2_k127_4898513_1 396588.Tgr7_2256 2.202e-222 697.0 COG1249@1|root,COG1249@2|Bacteria,1RB5F@1224|Proteobacteria,1S51N@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family lpdA_2 - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim MMS2_k127_4898513_7 572477.Alvin_0868 7.544e-51 184.0 COG0607@1|root,COG0607@2|Bacteria,1RKAQ@1224|Proteobacteria,1SC2Q@1236|Gammaproteobacteria,1X1H4@135613|Chromatiales 135613|Chromatiales P Rhodanese-like domain - - - - - - - - - - - - Rhodanese MMS2_k127_4898513_11 2340.JV46_16390 1.377e-08 61.0 2ESVH@1|root,33KDW@2|Bacteria,1NI9I@1224|Proteobacteria,1SJ2N@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4898513_2 519989.ECTPHS_02966 4.949e-189 600.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD MMS2_k127_4898513_8 396588.Tgr7_2266 2.262e-29 120.0 2FC5D@1|root,34497@2|Bacteria,1P0GU@1224|Proteobacteria,1SR44@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_4898513_0 314278.NB231_05811 1.05e-225 722.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD MMS2_k127_4898513_4 396588.Tgr7_2268 2.687e-107 360.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase MMS2_k127_4898513_6 396588.Tgr7_2270 7.732e-57 207.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales 135613|Chromatiales S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 MMS2_k127_4899526_13 1232453.BAIF02000066_gene2058 0.0004237 48.0 2DPR3@1|root,3331G@2|Bacteria,1VS4P@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - MMS2_k127_4899526_0 396588.Tgr7_0033 2.115e-228 715.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1WWNX@135613|Chromatiales 135613|Chromatiales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 MMS2_k127_4899526_4 396588.Tgr7_0032 3.146e-86 297.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1WYMY@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase MMS2_k127_4899526_7 686578.AFFX01000010_gene2320 1.606e-57 208.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Response regulator of the LytR AlgR family algR - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg MMS2_k127_4899526_3 396588.Tgr7_3281 3.545e-110 366.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales 135613|Chromatiales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N MMS2_k127_4899526_8 243233.MCA2537 9.907e-53 190.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1XEZ2@135618|Methylococcales 135618|Methylococcales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB MMS2_k127_4899526_12 1333856.L686_07580 1.705e-30 126.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1Z38N@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin MMS2_k127_4899526_10 765914.ThisiDRAFT_1427 1.211e-43 163.0 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,1WZD4@135613|Chromatiales 135613|Chromatiales P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese MMS2_k127_4899526_9 1279019.ARQK01000050_gene1296 1.963e-46 169.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1WYHD@135613|Chromatiales 135613|Chromatiales K regulatory protein, arsR - - - - - - - - - - - - HTH_5 MMS2_k127_4899526_5 396588.Tgr7_3287 1.291e-80 284.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales 135613|Chromatiales D PFAM peptidase - - - - - - - - - - - - Peptidase_M23 MMS2_k127_4899526_1 1049564.TevJSym_at00280 8.023e-142 466.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J4IS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 MMS2_k127_4899526_6 396588.Tgr7_3289 8.526e-73 265.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1X0WV@135613|Chromatiales 135613|Chromatiales S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 MMS2_k127_4899526_11 1049564.TevJSym_at00300 5.07e-39 162.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1J6UZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DJ-1/PfpI family thiJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009100,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019538,GO:0022613,GO:0030091,GO:0033554,GO:0034599,GO:0036211,GO:0036524,GO:0036525,GO:0042026,GO:0042221,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901564 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI MMS2_k127_4899526_2 266779.Meso_2710 1.215e-133 431.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43IYZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily smoK - - ko:K10111 ko02010,map02010 M00194,M00200,M00204,M00207,M00491 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 MMS2_k127_4942028_4 765912.Thimo_0412 2.133e-31 143.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1WWU1@135613|Chromatiales 135613|Chromatiales S TamB, inner membrane protein subunit of TAM complex - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB MMS2_k127_4942028_0 713586.KB900536_gene2570 3.226e-145 481.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales 135613|Chromatiales M Surface antigen variable number - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 MMS2_k127_4942028_2 1304275.C41B8_07397 7.548e-63 226.0 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,1S35N@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG1596 Periplasmic protein involved in polysaccharide export wza - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB MMS2_k127_4942028_1 1304275.C41B8_07402 8.279e-116 392.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein involved in exopolysaccharide biosynthesis - - - - - - - - - - - - GNVR,Wzz MMS2_k127_4942028_3 765911.Thivi_4256 2.899e-58 214.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1WWGG@135613|Chromatiales 135613|Chromatiales D AAA domain - - - - - - - - - - - - AAA_31,CbiA MMS2_k127_4978802_2 396588.Tgr7_2048 3.699e-179 570.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1WWGZ@135613|Chromatiales 135613|Chromatiales J PFAM tRNA synthetase class II (G H P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His MMS2_k127_4978802_7 557598.LHK_00687 6.402e-29 128.0 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria,2KRAR@206351|Neisseriales 206351|Neisseriales S Tetratricopeptide repeat-like domain - - - - - - - - - - - - TPR_21 MMS2_k127_4978802_5 713586.KB900536_gene447 6.432e-101 344.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1WWQT@135613|Chromatiales 135613|Chromatiales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 MMS2_k127_4978802_3 1049564.TevJSym_ac01890 1.771e-173 556.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 MMS2_k127_4978802_4 1049564.TevJSym_ab00620 3.792e-155 499.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1J5BC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II IV02_28760 - - - - - - - - - - - Aminotran_1_2 MMS2_k127_4978802_1 396588.Tgr7_1817 4.133e-211 665.0 COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,1RY8F@1236|Gammaproteobacteria,1WZYN@135613|Chromatiales 135613|Chromatiales E 4-Hydroxyphenylpyruvate dioxygenase - - - - - - - - - - - - - MMS2_k127_4978802_6 998674.ATTE01000001_gene2311 3.933e-51 192.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,460VD@72273|Thiotrichales 72273|Thiotrichales E High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ - - ko:K06203 - - - - ko00000 - - - EI24 MMS2_k127_4978802_0 396588.Tgr7_1176 0.0 1580.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon MMS2_k127_5016895_20 1247963.JPHU01000001_gene1923 1.793e-14 82.0 COG0546@1|root,COG0546@2|Bacteria,1RED3@1224|Proteobacteria,2U7YV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S phosphoglycolate phosphatase activity - - - - - - - - - - - - Acid_phosphat_B MMS2_k127_5016895_6 637390.AFOH01000055_gene1628 1.143e-181 583.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,2NCN9@225057|Acidithiobacillales 225057|Acidithiobacillales O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 MMS2_k127_5016895_18 314278.NB231_06211 2.923e-19 90.0 2EGMT@1|root,33ADY@2|Bacteria,1NH3I@1224|Proteobacteria,1SGAI@1236|Gammaproteobacteria,1WZTM@135613|Chromatiales 135613|Chromatiales S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N MMS2_k127_5016895_11 1123368.AUIS01000008_gene2229 7.961e-74 258.0 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,1S3U0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - DUF938 MMS2_k127_5016895_10 1089551.KE386572_gene1157 3.316e-86 301.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,4BQ5F@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Amino acid amide ABC transporter substrate-binding protein, HAAT family - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 MMS2_k127_5016895_0 555778.Hneap_0830 2.518e-231 721.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1WWHM@135613|Chromatiales 135613|Chromatiales Q TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM MMS2_k127_5016895_12 555778.Hneap_0831 8.207e-72 247.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WYXN@135613|Chromatiales 135613|Chromatiales Q PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - - - - - - - - - - DctQ MMS2_k127_5016895_3 555778.Hneap_0832 1.471e-202 635.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,1RNCK@1236|Gammaproteobacteria,1WW0A@135613|Chromatiales 135613|Chromatiales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal MMS2_k127_5016895_8 1123393.KB891317_gene2192 1.905e-139 447.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2VJB2@28216|Betaproteobacteria 28216|Betaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase MMS2_k127_5016895_1 1123399.AQVE01000001_gene734 4.704e-212 662.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,46037@72273|Thiotrichales 72273|Thiotrichales C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N MMS2_k127_5016895_4 1049564.TevJSym_ar00580 2.719e-202 648.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1J52N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N MMS2_k127_5016895_19 1123399.AQVE01000001_gene570 2.611e-18 97.0 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,1SGKD@1236|Gammaproteobacteria,46347@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 MMS2_k127_5016895_9 396588.Tgr7_0673 3.394e-88 299.0 COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,1S31N@1236|Gammaproteobacteria,1WXP2@135613|Chromatiales 135613|Chromatiales G PFAM Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P MMS2_k127_5016895_14 519989.ECTPHS_06297 3.132e-57 203.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1WYPS@135613|Chromatiales 135613|Chromatiales O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR MMS2_k127_5016895_15 555778.Hneap_0229 9.244e-57 203.0 COG0668@1|root,COG0668@2|Bacteria,1MZKZ@1224|Proteobacteria,1SWSI@1236|Gammaproteobacteria,1X1UG@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel MMS2_k127_5016895_7 519989.ECTPHS_03879 2.198e-141 458.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales 135613|Chromatiales HJ Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N MMS2_k127_5016895_13 187272.Mlg_0355 1.172e-59 212.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1WY6S@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02657 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg MMS2_k127_5016895_16 713586.KB900536_gene1693 5.461e-52 186.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,1WYZY@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg MMS2_k127_5016895_17 396588.Tgr7_2902 1.986e-39 156.0 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria,1WY0H@135613|Chromatiales 135613|Chromatiales NT PFAM CheW domain protein - - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW MMS2_k127_5016895_2 396588.Tgr7_2901 6.278e-212 680.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ MMS2_k127_5016895_5 713586.KB900536_gene1690 8.543e-194 654.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg MMS2_k127_5027033_21 1268068.PG5_42280 6.256e-49 186.0 COG4228@1|root,COG4228@2|Bacteria,1R4HU@1224|Proteobacteria,1RPRY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA circulation protein - - - - - - - - - - - - DNA_circ_N MMS2_k127_5027033_12 1268068.PG5_42290 1.043e-81 294.0 COG5412@1|root,COG5412@2|Bacteria,1QZ38@1224|Proteobacteria 1224|Proteobacteria S phage tail tape measure protein - - - - - - - - - - - - - MMS2_k127_5027033_23 1268068.PG5_42320 3.762e-46 169.0 2DP11@1|root,33031@2|Bacteria,1RH3P@1224|Proteobacteria 1224|Proteobacteria S Phage tail tube protein - - - - - - - - - - - - Tail_tube MMS2_k127_5027033_2 1268068.PG5_42330 3.615e-179 573.0 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,1RN4Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria N Tail sheath protein - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C MMS2_k127_5027033_42 1121413.JMKT01000009_gene1864 2.709e-09 63.0 2EICU@1|root,33C46@2|Bacteria,1NGMA@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF2635) - - - - - - - - - - - - DUF2635 MMS2_k127_5027033_31 1268068.PG5_42350 7.364e-25 112.0 2EU1Z@1|root,33MJ0@2|Bacteria,1NN57@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_9 86106.I862_04310 3.368e-88 302.0 2C57E@1|root,2Z8WK@2|Bacteria,1PPA2@1224|Proteobacteria,2TS2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phage major capsid protein E - - - - - - - - - - - - Phage_cap_E MMS2_k127_5027033_33 748280.NH8B_0557 1.374e-21 98.0 2DMA4@1|root,32B9P@2|Bacteria,1MYHB@1224|Proteobacteria,2VWB5@28216|Betaproteobacteria,2KTAY@206351|Neisseriales 206351|Neisseriales S Bacteriophage lambda head decoration protein D - - - - - - - - - - - - HDPD MMS2_k127_5027033_11 1122201.AUAZ01000004_gene3425 6.645e-86 304.0 COG0616@1|root,COG0616@2|Bacteria,1QGPW@1224|Proteobacteria,1RZZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU peptidase JD73_18850 - - ko:K21511 - - - - ko00000,ko01000 - - - Peptidase_S49 MMS2_k127_5027033_0 1122201.AUAZ01000004_gene3426 7.223e-191 614.0 COG5511@1|root,COG5511@2|Bacteria,1MVN4@1224|Proteobacteria,1RPUT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage portal protein, lambda family JD73_18735 - - - - - - - - - - - Phage_portal_2 MMS2_k127_5027033_46 748280.NH8B_0563 6.39e-08 57.0 2EVVM@1|root,33P9A@2|Bacteria,1NKMR@1224|Proteobacteria,2W6KW@28216|Betaproteobacteria,2KTK2@206351|Neisseriales 206351|Neisseriales S gpW - - - - - - - - - - - - gpW MMS2_k127_5027033_1 1278073.MYSTI_01933 9.76e-188 606.0 COG5525@1|root,COG5525@2|Bacteria,1MVS3@1224|Proteobacteria,42MCU@68525|delta/epsilon subdivisions,2WJ3Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA MMS2_k127_5027033_34 637389.Acaty_c0106 2.999e-20 98.0 2BT59@1|root,32NA4@2|Bacteria,1Q8RF@1224|Proteobacteria,1TBV5@1236|Gammaproteobacteria,2NDZ1@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - MMS2_k127_5027033_5 1121440.AUMA01000011_gene2416 1.406e-122 412.0 COG0863@1|root,COG1475@1|root,COG0863@2|Bacteria,COG1475@2|Bacteria,1MVH7@1224|Proteobacteria,42X97@68525|delta/epsilon subdivisions,2WNMY@28221|Deltaproteobacteria,2MA3E@213115|Desulfovibrionales 28221|Deltaproteobacteria KL DNA methylase - - - - - - - - - - - - N6_N4_Mtase,ParBc MMS2_k127_5027033_14 1114964.L485_22345 8.16e-63 224.0 2DTGW@1|root,33K9X@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_6 1140.Synpcc7942_0727 2.537e-117 413.0 COG4643@1|root,COG5519@1|root,COG4643@2|Bacteria,COG5519@2|Bacteria,1GPEJ@1117|Cyanobacteria,1H31N@1129|Synechococcus 1117|Cyanobacteria L DNA primase - - - ko:K06919 - - - - ko00000 - - - Prim_Zn_Ribbon MMS2_k127_5027033_35 1395516.PMO01_24930 6.182e-19 103.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 MMS2_k127_5027033_18 247156.NFA_40350 3.548e-55 197.0 2DG0N@1|root,2ZTZ8@2|Bacteria,2HK0H@201174|Actinobacteria,4G7PZ@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_20 136993.KB900626_gene1839 1.939e-51 188.0 COG1917@1|root,COG1917@2|Bacteria,1N6Q0@1224|Proteobacteria,2UKI2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - MMS2_k127_5027033_27 439375.Oant_1558 5.914e-35 150.0 2ECJ7@1|root,336HA@2|Bacteria,1N1RH@1224|Proteobacteria,2UTN7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_29 391038.Bphy_1866 6.414e-29 126.0 29U8E@1|root,30FIE@2|Bacteria,1PYUS@1224|Proteobacteria,2WDZ6@28216|Betaproteobacteria,1KBAI@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_40 1234364.AMSF01000010_gene574 1.867e-12 73.0 2E8XG@1|root,3337G@2|Bacteria,1N7HF@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - HTH_17 MMS2_k127_5027033_30 1216976.AX27061_3526 1.767e-26 126.0 COG0419@1|root,COG0419@2|Bacteria,1R4K4@1224|Proteobacteria,2VJVF@28216|Betaproteobacteria 28216|Betaproteobacteria L AAA domain recF - - - - - - - - - - - AAA_23 MMS2_k127_5027033_17 1123508.JH636446_gene6408 3.072e-55 211.0 COG0468@1|root,COG0468@2|Bacteria,2J132@203682|Planctomycetes 203682|Planctomycetes L AAA domain - - - - - - - - - - - - AAA_24 MMS2_k127_5027033_10 1216966.BAUC01000041_gene2888 5.258e-86 293.0 2DBI5@1|root,2Z9EN@2|Bacteria,1PMHG@1224|Proteobacteria,1RQE1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Exodeoxyribonuclease VIII - - - ko:K10906 - - - - ko00000,ko01000,ko03400 - - - DUF3799 MMS2_k127_5027033_39 634177.GLX_04470 9.992e-13 77.0 COG2932@1|root,COG3620@1|root,COG2932@2|Bacteria,COG3620@2|Bacteria,1RI6R@1224|Proteobacteria,2UB6P@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Peptidase S24-like - - - - - - - - - - - - HTH_19,HTH_3,Peptidase_S24 MMS2_k127_5027033_7 587753.EY04_17455 2.603e-115 382.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPSH@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase,Dam,MethyltransfD12 MMS2_k127_5027033_4 269084.syc0806_c 2.346e-124 421.0 COG1061@1|root,COG1061@2|Bacteria,1G2HP@1117|Cyanobacteria,1H08U@1129|Synechococcus 1117|Cyanobacteria L Helicase conserved C-terminal domain - - - - - - - - - - - - DUF3427,Helicase_C,ResIII MMS2_k127_5027033_36 859657.RPSI07_0232 8.05e-16 80.0 2BAZ4@1|root,324F0@2|Bacteria,1MYJ1@1224|Proteobacteria,2W24B@28216|Betaproteobacteria,1K9BV@119060|Burkholderiaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_15 190650.CC_2681 1.185e-59 222.0 COG0582@1|root,COG0582@2|Bacteria,1R43H@1224|Proteobacteria,2TT0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase MMS2_k127_5027033_43 1429916.X566_00540 9.913e-09 61.0 COG2771@1|root,COG2771@2|Bacteria,1RE9I@1224|Proteobacteria,2TXIA@28211|Alphaproteobacteria,3K6WM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Autoinducer binding domain - - - ko:K18098 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - Autoind_bind,GerE MMS2_k127_5027033_19 1415780.JPOG01000001_gene1769 6.222e-53 192.0 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,1SEFX@1236|Gammaproteobacteria,1X8WI@135614|Xanthomonadales 135614|Xanthomonadales S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 MMS2_k127_5027033_26 1205680.CAKO01000006_gene3381 8.198e-37 149.0 COG4675@1|root,COG4675@2|Bacteria,1N9JB@1224|Proteobacteria,2UIAU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S tail collar domain protein - - - - - - - - - - - - - MMS2_k127_5027033_37 883.DvMF_0751 2.613e-15 85.0 2BAIT@1|root,323ZG@2|Bacteria,1PDU3@1224|Proteobacteria,432X7@68525|delta/epsilon subdivisions,2WXHV@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - MMS2_k127_5027033_28 1123487.KB892865_gene1344 1.035e-29 122.0 COG0286@1|root,COG0286@2|Bacteria,1R1JB@1224|Proteobacteria 1224|Proteobacteria V Phage tail assembly chaperone protein - - - - - - - - - - - - Phage_tail_APC MMS2_k127_5027033_38 882.DVU_0220 9.391e-13 77.0 COG5301@1|root,COG5301@2|Bacteria,1NI8B@1224|Proteobacteria,43BJU@68525|delta/epsilon subdivisions,2X6XP@28221|Deltaproteobacteria,2MDJX@213115|Desulfovibrionales 28221|Deltaproteobacteria S tail collar domain protein - - - - - - - - - - - - - MMS2_k127_5027033_13 1268068.PG5_42230 8.195e-66 235.0 COG3778@1|root,COG3778@2|Bacteria,1N3CF@1224|Proteobacteria,1S3EK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein conserved in bacteria (DUF2313) ymfQ - - - - - - - - - - - DUF2313 MMS2_k127_5027033_8 1268068.PG5_42240 3.021e-111 374.0 COG3299@1|root,COG3299@2|Bacteria,1PYEJ@1224|Proteobacteria,1S5FS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S of phage Mu protein gp47 jayE - - - - - - - - - - - Baseplate_J MMS2_k127_5027033_24 1268068.PG5_42250 2.713e-44 165.0 COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,1SBHY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage FluMu protein - - - - - - - - - - - - GP46 MMS2_k127_5027033_25 1268068.PG5_42260 1.6e-39 156.0 COG4384@1|root,COG4384@2|Bacteria,1MZ4H@1224|Proteobacteria 1224|Proteobacteria S assembly protein - - - - - - - - - - - - Phage_Mu_Gp45 MMS2_k127_5027033_3 1268068.PG5_42270 4.95e-126 414.0 COG4379@1|root,COG4379@2|Bacteria,1MX68@1224|Proteobacteria,1RYCD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S tail protein - - - - - - - - - - - - Phage_GPD MMS2_k127_5027033_22 1268068.PG5_42280 1.933e-48 183.0 COG4228@1|root,COG4228@2|Bacteria,1R4HU@1224|Proteobacteria,1RPRY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA circulation protein - - - - - - - - - - - - DNA_circ_N MMS2_k127_514091_10 903818.KI912268_gene2214 3.855e-09 59.0 COG0643@1|root,COG0643@2|Bacteria,3Y3WE@57723|Acidobacteria 57723|Acidobacteria NT Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt MMS2_k127_514091_4 338969.Rfer_0902 1.668e-131 437.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AB4J@80864|Comamonadaceae 28216|Betaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406,ko:K03776,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,TarH MMS2_k127_514091_6 1123368.AUIS01000004_gene203 3.935e-55 198.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,1S4DQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT Chemotaxis protein CheW cheW-1 - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW MMS2_k127_514091_5 748247.AZKH_4200 3.213e-94 317.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,2KUUF@206389|Rhodocyclales 206389|Rhodocyclales H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N MMS2_k127_514091_7 580332.Slit_1584 1.46e-47 177.0 COG1871@1|root,COG1871@2|Bacteria,1RI55@1224|Proteobacteria,2VUAC@28216|Betaproteobacteria,44WIV@713636|Nitrosomonadales 28216|Betaproteobacteria NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD MMS2_k127_514091_3 1123368.AUIS01000004_gene208 5.991e-140 458.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB2 - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg MMS2_k127_514091_9 765912.Thimo_0163 1.925e-18 88.0 COG4575@1|root,COG4575@2|Bacteria 2|Bacteria T ribosome binding MA20_18275 - - - - - - - - - - - DUF883 MMS2_k127_514091_1 1408418.JNJH01000036_gene526 3.132e-220 703.0 COG4987@1|root,COG4987@2|Bacteria,1QU1P@1224|Proteobacteria,2TV54@28211|Alphaproteobacteria,2JPUK@204441|Rhodospirillales 204441|Rhodospirillales CO ABC transporter - - - ko:K16012 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_tran MMS2_k127_514091_0 1408418.JNJH01000036_gene525 7.136e-238 758.0 COG4988@1|root,COG4988@2|Bacteria,1QU1N@1224|Proteobacteria,2TTGB@28211|Alphaproteobacteria,2JRIQ@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter - - - ko:K16013 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran MMS2_k127_514091_2 472759.Nhal_3135 3.752e-169 545.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WWS4@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat MMS2_k127_514091_8 323261.Noc_1624 2.361e-26 111.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SZ4W@1236|Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA MMS2_k127_541241_7 1123368.AUIS01000010_gene2400 1.454e-43 160.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RMUV@1236|Gammaproteobacteria,2NE6V@225057|Acidithiobacillales 1236|Gammaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - CHASE,CHASE5,CHASE8,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 MMS2_k127_541241_6 292415.Tbd_1192 1.5e-65 231.0 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2WGQ0@28216|Betaproteobacteria,1KT24@119069|Hydrogenophilales 119069|Hydrogenophilales T cheY-homologous receiver domain - - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg MMS2_k127_541241_0 1123393.KB891327_gene428 9.138e-305 954.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KSPT@119069|Hydrogenophilales 119069|Hydrogenophilales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,Response_reg MMS2_k127_541241_8 1121935.AQXX01000114_gene3246 1.1e-35 146.0 COG1917@1|root,COG1917@2|Bacteria,1MZNT@1224|Proteobacteria,1S8TU@1236|Gammaproteobacteria,1XMGH@135619|Oceanospirillales 135619|Oceanospirillales S Cupin domain - - - ko:K11312 - - - - ko00000 - - - Cupin_2 MMS2_k127_541241_5 1163408.UU9_09877 2.525e-68 249.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,1S6QU@1236|Gammaproteobacteria,1X616@135614|Xanthomonadales 135614|Xanthomonadales T Diguanylate cyclase - - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 MMS2_k127_541241_4 204773.HEAR1081 6.865e-88 297.0 COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria,474I0@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF1211) - - - - - - - - - - - - DUF1211 MMS2_k127_541241_3 526227.Mesil_2804 3.228e-92 311.0 COG0834@1|root,COG0834@2|Bacteria,1WMI9@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus ET Bacterial periplasmic substrate-binding proteins - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 MMS2_k127_541241_2 526227.Mesil_2805 3.156e-107 358.0 COG0765@1|root,COG0765@2|Bacteria 2|Bacteria P amino acid transport - - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 MMS2_k127_541241_1 926560.KE387023_gene3701 2.091e-123 398.0 COG1126@1|root,COG1126@2|Bacteria,1WI0Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E ABC-type polar amino acid transport system ATPase component - - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran MMS2_k127_553889_0 1173028.ANKO01000044_gene768 1.201e-122 414.0 COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1G26V@1117|Cyanobacteria,1H78U@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - ko:K13490 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01001,ko02022 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg MMS2_k127_556356_7 396588.Tgr7_1488 4.979e-67 230.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,1WW3I@135613|Chromatiales 135613|Chromatiales C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters - - - ko:K04488 - - - - ko00000 - - - NifU_N MMS2_k127_556356_1 519989.ECTPHS_05050 1.019e-206 649.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWFM@135613|Chromatiales 135613|Chromatiales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 MMS2_k127_556356_8 396588.Tgr7_2060 3.501e-62 217.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WVXA@135613|Chromatiales 135613|Chromatiales K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 MMS2_k127_556356_3 472759.Nhal_1928 1.892e-109 359.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1WW81@135613|Chromatiales 135613|Chromatiales E TIGRFAM Serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N MMS2_k127_556356_6 1179778.PMM47T1_04234 5.82e-82 280.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase MMS2_k127_556356_4 519989.ECTPHS_12783 1.103e-106 355.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,1WWE2@135613|Chromatiales 135613|Chromatiales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P MMS2_k127_556356_5 1286106.MPL1_06084 5.097e-105 349.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,45ZWD@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG MMS2_k127_556356_0 396588.Tgr7_2066 5.272e-229 724.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG MMS2_k127_556356_9 1123401.JHYQ01000015_gene1383 4.083e-40 152.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,4613V@72273|Thiotrichales 72273|Thiotrichales U Preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC MMS2_k127_556356_2 396588.Tgr7_2068 1.638e-189 598.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales 135613|Chromatiales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT MMS2_k127_558636_1 998674.ATTE01000001_gene1788 1.982e-69 241.0 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,1RYH6@1236|Gammaproteobacteria,45ZY6@72273|Thiotrichales 72273|Thiotrichales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ MMS2_k127_558636_0 870187.Thini_2554 4.461e-148 477.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,460AH@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM MMS2_k127_558636_2 1123401.JHYQ01000007_gene546 1.563e-26 115.0 COG0746@1|root,COG0746@2|Bacteria,1NBH1@1224|Proteobacteria,1SDF0@1236|Gammaproteobacteria,4635D@72273|Thiotrichales 72273|Thiotrichales H Protein of unknown function (DUF3305) - - - - - - - - - - - - DUF3305 MMS2_k127_558636_3 1123401.JHYQ01000007_gene545 4.335e-22 105.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,1T214@1236|Gammaproteobacteria,461U9@72273|Thiotrichales 72273|Thiotrichales C 4Fe-4S binding domain - - - - - - - - - - - - DUF3306,Fer4 MMS2_k127_611085_5 553385.JEMF01000018_gene888 0.0001959 44.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1XI0M@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon MMS2_k127_611085_0 765914.ThisiDRAFT_0322 1.43e-158 504.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1WX6T@135613|Chromatiales 135613|Chromatiales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA MMS2_k127_611085_1 555778.Hneap_1260 2.973e-136 445.0 COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1MZV7@1224|Proteobacteria,1RPR0@1236|Gammaproteobacteria,1WYFU@135613|Chromatiales 135613|Chromatiales T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3,PAS_4,PAS_9 MMS2_k127_611085_3 396588.Tgr7_1178 1.451e-117 392.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C MMS2_k127_611085_4 1049564.TevJSym_as00630 3.546e-65 229.0 COG2862@1|root,COG2862@2|Bacteria,1RFUX@1224|Proteobacteria,1S75J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein family, UPF0114 - - - - - - - - - - - - UPF0114 MMS2_k127_611085_2 1266914.ATUK01000001_gene763 5.886e-124 407.0 COG0095@1|root,COG0095@2|Bacteria,1RDZE@1224|Proteobacteria 1224|Proteobacteria H PFAM biotin lipoate A B protein ligase - - 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB,Lip_prot_lig_C MMS2_k127_611658_26 1441629.PCH70_37590 5.509e-23 100.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1Z6XC@136849|Pseudomonas syringae group 1236|Gammaproteobacteria F Amidohydrolase family mtaD - 3.5.4.28,3.5.4.31,3.5.4.32 ko:K12960,ko:K18456 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 MMS2_k127_611658_5 570967.JMLV01000002_gene1806 4.422e-149 478.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2JQBK@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N MMS2_k127_611658_3 1500890.JQNL01000001_gene1640 1.244e-186 598.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,1X52U@135614|Xanthomonadales 135614|Xanthomonadales E aminotransferase tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 MMS2_k127_611658_22 555778.Hneap_1654 6.612e-52 187.0 COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,1S9UN@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase MMS2_k127_611658_10 396588.Tgr7_1530 7.621e-108 353.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1WX56@135613|Chromatiales 135613|Chromatiales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 MMS2_k127_611658_21 713587.THITH_09095 1.325e-72 252.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1WXXM@135613|Chromatiales 135613|Chromatiales S HAD-superfamily hydrolase, subfamily IA, variant 1 - - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 MMS2_k127_611658_7 498211.CJA_0367 2.099e-123 404.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,1RNHI@1236|Gammaproteobacteria,1FFXD@10|Cellvibrio 1236|Gammaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - APH MMS2_k127_611658_0 1121033.AUCF01000021_gene2886 0.0 1645.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B MMS2_k127_611658_11 713586.KB900536_gene579 4.1e-97 325.0 COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,1S3EY@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Squalene/phytoene synthase - - - - - - - - - - - - SQS_PSY MMS2_k127_611658_6 396588.Tgr7_1524 8.222e-136 438.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,1RNRI@1236|Gammaproteobacteria,1WYA5@135613|Chromatiales 135613|Chromatiales I Squalene phytoene synthase - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY MMS2_k127_611658_15 396588.Tgr7_1523 1.964e-85 308.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,1SI1R@1236|Gammaproteobacteria,1WWZB@135613|Chromatiales 135613|Chromatiales H Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase MMS2_k127_611658_12 396588.Tgr7_1522 1.811e-93 313.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1WWXV@135613|Chromatiales 135613|Chromatiales IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short MMS2_k127_611658_9 713586.KB900536_gene72 5.19e-108 364.0 COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,1RZ7R@1236|Gammaproteobacteria,1WX5T@135613|Chromatiales 135613|Chromatiales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 MMS2_k127_611658_14 1123400.KB904746_gene1192 2.418e-90 310.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,45ZPI@72273|Thiotrichales 72273|Thiotrichales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 MMS2_k127_611658_18 396588.Tgr7_2011 2.134e-82 276.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1WXCN@135613|Chromatiales 135613|Chromatiales H May be involved in the biosynthesis of molybdopterin - - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth MMS2_k127_611658_25 1123518.ARWI01000001_gene2044 1.754e-33 135.0 COG2246@1|root,COG2246@2|Bacteria,1RJUK@1224|Proteobacteria,1SAXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S GtrA-like protein - - - - - - - - - - - - GtrA MMS2_k127_611658_17 713586.KB900536_gene604 2.046e-82 279.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1WW3N@135613|Chromatiales 135613|Chromatiales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB MMS2_k127_611658_8 396588.Tgr7_2013 2.561e-109 360.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1WW4R@135613|Chromatiales 135613|Chromatiales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves - - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA MMS2_k127_611658_1 519989.ECTPHS_05325 3.315e-212 664.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales 135613|Chromatiales J TIGRFAM Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b MMS2_k127_611658_19 396588.Tgr7_2016 5.236e-77 264.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,1S4N8@1236|Gammaproteobacteria,1WWRR@135613|Chromatiales 135613|Chromatiales S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 MMS2_k127_611658_13 870187.Thini_0536 8.761e-91 306.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,460FH@72273|Thiotrichales 72273|Thiotrichales J Belongs to the SUA5 family - - - - - - - - - - - - Sua5_yciO_yrdC MMS2_k127_611658_20 472759.Nhal_2314 3.517e-73 253.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1WX92@135613|Chromatiales 135613|Chromatiales D probably involved in intracellular septation - - - ko:K06190 - - - - ko00000 - - - IspA MMS2_k127_611658_24 713587.THITH_09570 4.502e-39 153.0 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1WYXH@135613|Chromatiales 135613|Chromatiales S PFAM YCII-related - - - ko:K09780 - - - - ko00000 - - - YCII MMS2_k127_611658_16 1123401.JHYQ01000013_gene628 7.661e-83 280.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,460FA@72273|Thiotrichales 72273|Thiotrichales L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T MMS2_k127_611658_4 1123400.KB904813_gene3071 1.278e-153 496.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,45ZWZ@72273|Thiotrichales 72273|Thiotrichales O PFAM Peptidase family M48 - - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N MMS2_k127_611658_2 713586.KB900536_gene614 1.763e-187 606.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1WVV4@135613|Chromatiales 135613|Chromatiales L AAA ATPase, central domain protein - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N MMS2_k127_611658_23 582744.Msip34_1192 3.795e-49 182.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,2KMKK@206350|Nitrosomonadales 206350|Nitrosomonadales M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA MMS2_k127_624648_3 396588.Tgr7_3000 6.909e-180 567.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales 135613|Chromatiales C Belongs to the heme-copper respiratory oxidase family - - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 MMS2_k127_624648_7 768671.ThimaDRAFT_3356 6.423e-90 305.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 MMS2_k127_624648_8 2340.JV46_25110 4.548e-67 238.0 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1J6BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf MMS2_k127_624648_6 1577887.JSYG01000037_gene2181 1.235e-152 488.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,2JCDS@204037|Dickeya 1236|Gammaproteobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 MMS2_k127_624648_14 713586.KB900536_gene1825 3.556e-30 120.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 MMS2_k127_624648_13 713586.KB900536_gene1826 1.864e-46 172.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1WYDV@135613|Chromatiales 135613|Chromatiales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY MMS2_k127_624648_1 396588.Tgr7_3019 9.612e-264 821.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 MMS2_k127_624648_2 713586.KB900536_gene1828 2.162e-183 584.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D MMS2_k127_624648_12 519989.ECTPHS_06512 2.096e-47 177.0 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X2NE@135613|Chromatiales 135613|Chromatiales S mRNA catabolic process - - - - - - - - - - - - - MMS2_k127_624648_0 713586.KB900536_gene1830 5.038e-273 864.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase MMS2_k127_624648_5 396588.Tgr7_3023 6.807e-153 490.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus assembly protein PilM - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 MMS2_k127_624648_11 765914.ThisiDRAFT_0888 3.266e-55 199.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales 135613|Chromatiales NU PFAM Fimbrial assembly - - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN MMS2_k127_624648_9 519989.ECTPHS_06492 7.526e-57 204.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales 135613|Chromatiales NU Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO MMS2_k127_624648_10 713586.KB900536_gene1834 2.343e-55 200.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales 135613|Chromatiales NU pilus assembly protein PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP MMS2_k127_624648_4 314278.NB231_06156 5.359e-176 578.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N MMS2_k127_624648_15 1035839.AFNK01000053_gene834 5.26e-11 64.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1Y75T@135625|Pasteurellales 135625|Pasteurellales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI MMS2_k127_637262_3 1234364.AMSF01000017_gene1419 5.379e-50 183.0 2A8V4@1|root,30XYD@2|Bacteria,1QB91@1224|Proteobacteria,1T6TB@1236|Gammaproteobacteria,1X842@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - MMS2_k127_637262_0 1234364.AMSF01000017_gene1421 0.0 1008.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1X4K6@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia - - - - - - - - - - - - Amidase MMS2_k127_637262_1 1234364.AMSF01000017_gene1426 8.673e-177 556.0 COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,1X4SX@135614|Xanthomonadales 135614|Xanthomonadales I Acyltransferase - - - - - - - - - - - - Acyltransferase MMS2_k127_637262_2 1234364.AMSF01000017_gene1427 2.843e-147 467.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1X4J9@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 MMS2_k127_664770_6 631362.Thi970DRAFT_02731 5.412e-112 381.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1WXED@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N MMS2_k127_664770_0 713586.KB900536_gene2217 0.0 1343.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales 135613|Chromatiales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 MMS2_k127_664770_5 396588.Tgr7_0086 5.348e-123 397.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1RSPA@1236|Gammaproteobacteria,1WXV0@135613|Chromatiales 135613|Chromatiales S Cytokinin riboside 5'-monophosphate phosphoribohydrolase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox MMS2_k127_664770_7 1266925.JHVX01000003_gene558 1.042e-111 369.0 COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,37292@32003|Nitrosomonadales 28216|Betaproteobacteria F Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH MMS2_k127_664770_10 1162668.LFE_2308 4.459e-89 303.0 COG1024@1|root,COG1024@2|Bacteria,3J1EP@40117|Nitrospirae 40117|Nitrospirae I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K13767,ko:K13816 ko00071,ko00362,ko01100,ko01120,ko01212,ko02020,ko02024,map00071,map00362,map01100,map01120,map01212,map02020,map02024 M00087 R03026,R04170,R04738,R04740,R04744,R04746 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 MMS2_k127_664770_3 396588.Tgr7_0082 7.366e-168 556.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1X2QR@135613|Chromatiales 135613|Chromatiales T Histidine Phosphotransfer domain - - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg MMS2_k127_664770_8 1123368.AUIS01000032_gene1387 1.445e-105 354.0 COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2NCPY@225057|Acidithiobacillales 225057|Acidithiobacillales T HD domain - - - ko:K13815 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko02022 - - - HD,Response_reg MMS2_k127_664770_12 314278.NB231_10768 5.561e-64 226.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1WWX9@135613|Chromatiales 135613|Chromatiales D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 MMS2_k127_664770_13 2340.JV46_06000 3.785e-44 169.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1J6DD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2863 Cytochrome c553 cc4 - - - - - - - - - - - Cytochrom_C MMS2_k127_664770_1 713586.KB900536_gene2340 4.046e-212 677.0 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,1RXXZ@1236|Gammaproteobacteria,1X08B@135613|Chromatiales 135613|Chromatiales O ResB-like family - - - ko:K07399 - - - - ko00000 - - - ResB MMS2_k127_664770_4 1123401.JHYQ01000036_gene1681 3.252e-157 505.0 COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,1RX07@1236|Gammaproteobacteria,45ZPJ@72273|Thiotrichales 72273|Thiotrichales O PFAM Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm MMS2_k127_664770_14 396588.Tgr7_0092 5.398e-41 160.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1WYV2@135613|Chromatiales 135613|Chromatiales O Thiol disulfide interchange protein - - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA MMS2_k127_664770_9 765914.ThisiDRAFT_2538 7.457e-92 310.0 COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1RY1Q@1236|Gammaproteobacteria,1WX7C@135613|Chromatiales 135613|Chromatiales L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos MMS2_k127_664770_11 396588.Tgr7_0095 3.294e-81 279.0 COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,1RRWT@1236|Gammaproteobacteria,1WXVN@135613|Chromatiales 135613|Chromatiales G PfkB domain protein - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB MMS2_k127_664770_2 1283300.ATXB01000001_gene479 1.475e-199 633.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1XDS7@135618|Methylococcales 135618|Methylococcales M Sucrose phosphate synthase, sucrose phosphatase-like - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1,S6PP MMS2_k127_676001_0 1158762.KB898037_gene2354 0.0 1625.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding MMS2_k127_676001_11 1266909.AUAG01000009_gene623 1.017e-137 440.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1WWTE@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S - - - ko:K00184,ko:K21308 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 5.A.3 - - Fer4_11,Fer4_4,Fer4_7 MMS2_k127_676001_14 1266909.AUAG01000009_gene624 5.389e-106 354.0 COG3302@1|root,COG3302@2|Bacteria,1MWY1@1224|Proteobacteria,1RS3Q@1236|Gammaproteobacteria,1X23I@135613|Chromatiales 135613|Chromatiales S PFAM DMSO reductase anchor subunit (DmsC) - - - ko:K21309 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001 - - - DmsC MMS2_k127_676001_9 396588.Tgr7_0356 3.921e-182 582.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C MMS2_k127_676001_26 396588.Tgr7_0357 2.076e-56 201.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WY87@135613|Chromatiales 135613|Chromatiales O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin MMS2_k127_676001_3 519989.ECTPHS_02791 1.501e-252 781.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales 135613|Chromatiales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind MMS2_k127_676001_1 1163617.SCD_n02100 0.0 1030.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria 28216|Betaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase MMS2_k127_676001_7 519989.ECTPHS_02781 1.39e-193 615.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1WW3A@135613|Chromatiales 135613|Chromatiales F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N MMS2_k127_676001_16 395493.BegalDRAFT_1056 2.359e-99 332.0 COG1432@1|root,COG1432@2|Bacteria 2|Bacteria S NYN domain - - - - - - - - - - - - CSD,NYN MMS2_k127_676001_8 243159.AFE_0785 2.261e-183 589.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2NCS6@225057|Acidithiobacillales 225057|Acidithiobacillales E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept MMS2_k127_676001_20 243159.AFE_0764 8.506e-86 291.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,2NCXY@225057|Acidithiobacillales 225057|Acidithiobacillales S membrane transporter protein - - - - - - - - - - - - TauE MMS2_k127_676001_19 1121937.AUHJ01000002_gene3412 7.151e-86 301.0 COG2199@1|root,COG2199@2|Bacteria,1RGCV@1224|Proteobacteria,1S2US@1236|Gammaproteobacteria,467J3@72275|Alteromonadaceae 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21084 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - GGDEF,PAS_3,PAS_9 MMS2_k127_676001_2 396588.Tgr7_0361 3.494e-258 805.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1WWGN@135613|Chromatiales 135613|Chromatiales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS MMS2_k127_676001_5 1158146.KB907123_gene624 2.866e-221 696.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1WXMK@135613|Chromatiales 135613|Chromatiales S Polyphosphate AMP phosphotransferase - - - - - - - - - - - - PPK2 MMS2_k127_676001_24 396588.Tgr7_0485 1.602e-71 248.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,1WX4D@135613|Chromatiales 135613|Chromatiales O PFAM protein-L-isoaspartate(D-aspartate) O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT MMS2_k127_676001_15 396588.Tgr7_0483 3.656e-100 344.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales 135613|Chromatiales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP MMS2_k127_676001_30 1121413.JMKT01000016_gene72 5.411e-40 168.0 COG2199@1|root,COG3290@1|root,COG3290@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42S7S@68525|delta/epsilon subdivisions,2WNFR@28221|Deltaproteobacteria,2M9XW@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF,PAS,PAS_3,PAS_9,dCache_1 MMS2_k127_676001_21 497964.CfE428DRAFT_0704 1.328e-81 292.0 COG1738@1|root,COG1738@2|Bacteria 2|Bacteria S queuosine salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 MMS2_k127_676001_17 713586.KB900536_gene1793 1.785e-94 317.0 COG3001@1|root,COG3001@2|Bacteria,1MVHX@1224|Proteobacteria,1RRC5@1236|Gammaproteobacteria,1WXE3@135613|Chromatiales 135613|Chromatiales G PFAM Fructosamine - - - - - - - - - - - - Fructosamin_kin MMS2_k127_676001_31 396588.Tgr7_2979 4.231e-37 143.0 COG2346@1|root,COG2346@2|Bacteria,1RIHJ@1224|Proteobacteria 1224|Proteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin MMS2_k127_676001_29 519989.ECTPHS_10686 4.104e-48 184.0 COG1280@1|root,COG1280@2|Bacteria,1RF18@1224|Proteobacteria,1S4TM@1236|Gammaproteobacteria,1WYI1@135613|Chromatiales 135613|Chromatiales E PFAM Lysine exporter protein (LYSE YGGA) - - - - - - - - - - - - LysE MMS2_k127_676001_36 595460.RRSWK_02061 1.217e-05 53.0 2EPJ9@1|root,33H5X@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1451 MMS2_k127_676001_22 870187.Thini_3179 3.602e-81 289.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,460HG@72273|Thiotrichales 72273|Thiotrichales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 MMS2_k127_676001_12 713586.KB900536_gene1778 4.092e-108 358.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1S54F@1236|Gammaproteobacteria,1X0M8@135613|Chromatiales 135613|Chromatiales L 5'-3' exonuclease - - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N MMS2_k127_676001_6 1158165.KB898871_gene2219 5.631e-200 632.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1WVWD@135613|Chromatiales 135613|Chromatiales C PFAM malic - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic MMS2_k127_676001_25 713586.KB900536_gene1775 1.442e-57 211.0 COG1525@1|root,COG1525@2|Bacteria,1RKRQ@1224|Proteobacteria,1S7UH@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nuclease - - - - - - - - - - - - SNase MMS2_k127_676001_33 519989.ECTPHS_06677 1.803e-34 133.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1WZ1M@135613|Chromatiales 135613|Chromatiales J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 MMS2_k127_676001_4 519989.ECTPHS_06672 3.982e-223 699.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,1RN46@1236|Gammaproteobacteria,1WX1N@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 MMS2_k127_676001_34 637390.AFOH01000136_gene1804 1.263e-14 77.0 2EJQP@1|root,33DFH@2|Bacteria,1NI6C@1224|Proteobacteria,1SHDR@1236|Gammaproteobacteria,2NDEE@225057|Acidithiobacillales 225057|Acidithiobacillales C Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - - - - - - - - - - - MMS2_k127_676001_32 2340.JV46_11730 9.055e-35 137.0 COG0537@1|root,COG0537@2|Bacteria,1MZVD@1224|Proteobacteria,1S9D9@1236|Gammaproteobacteria,1J6NQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases hit1 - - - - - - - - - - - HIT MMS2_k127_676001_28 637389.Acaty_c0880 9.971e-50 182.0 COG1416@1|root,COG1416@2|Bacteria,1NBH7@1224|Proteobacteria,1SF4X@1236|Gammaproteobacteria,2NDB2@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF-like family - - - - - - - - - - - - DrsE MMS2_k127_676001_27 1349820.M707_05225 5.253e-53 189.0 COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria 201174|Actinobacteria J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP MMS2_k127_676001_18 292.DM42_7222 1.464e-87 296.0 COG1378@1|root,COG1378@2|Bacteria,1R5Z2@1224|Proteobacteria,2VIC4@28216|Betaproteobacteria,1KD04@119060|Burkholderiaceae 28216|Betaproteobacteria K Archaeal transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB MMS2_k127_676001_35 1123073.KB899241_gene2058 3.138e-11 72.0 2EGSV@1|root,33AIZ@2|Bacteria,1NGPG@1224|Proteobacteria,1SGM3@1236|Gammaproteobacteria,1X8YC@135614|Xanthomonadales 135614|Xanthomonadales S Cysteine-rich CPXCG - - - - - - - - - - - - Cys_rich_CPXG MMS2_k127_676001_10 1123401.JHYQ01000007_gene490 7.727e-146 484.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,45ZWG@72273|Thiotrichales 72273|Thiotrichales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - Fer4_14,HemN_C,Radical_SAM MMS2_k127_676001_23 396588.Tgr7_2961 1.233e-76 272.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales 135613|Chromatiales F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like MMS2_k127_676001_13 519989.ECTPHS_09368 3.183e-107 350.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1WW0F@135613|Chromatiales 135613|Chromatiales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C MMS2_k127_708144_0 1089552.KI911559_gene786 1.785e-156 501.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JPPV@204441|Rhodospirillales 204441|Rhodospirillales E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N MMS2_k127_708144_1 1089551.KE386572_gene485 7.428e-84 293.0 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,2TU4M@28211|Alphaproteobacteria,4BRZ2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EGP MFS_1 like family - - - - - - - - - - - - MFS_1,MFS_1_like,Sugar_tr MMS2_k127_708144_2 402626.Rpic_2998 4.942e-15 77.0 COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2VH7M@28216|Betaproteobacteria,1KFJ5@119060|Burkholderiaceae 28216|Betaproteobacteria G 2-keto-3-deoxy-galactonokinase dgoK - 2.7.1.58 ko:K00883 ko00052,ko01100,map00052,map01100 M00552 R03387 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - DGOK MMS2_k127_717289_1 396588.Tgr7_3149 2.371e-134 438.0 COG2199@1|root,COG3706@2|Bacteria,1R59V@1224|Proteobacteria,1S4YK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - - - - - - - - - - GGDEF,Response_reg MMS2_k127_717289_0 187272.Mlg_0941 0.0 1004.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 MMS2_k127_717289_4 396588.Tgr7_3147 6.147e-43 180.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S98H@1236|Gammaproteobacteria,1X18F@135613|Chromatiales 135613|Chromatiales S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin MMS2_k127_717289_5 1123368.AUIS01000008_gene2142 1.038e-38 149.0 COG2346@1|root,COG2346@2|Bacteria,1QCRH@1224|Proteobacteria,1SVZ9@1236|Gammaproteobacteria,2NCXP@225057|Acidithiobacillales 2|Bacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin MMS2_k127_717289_3 1158165.KB898879_gene2704 8.277e-75 258.0 COG5592@1|root,COG5592@2|Bacteria,1NWD3@1224|Proteobacteria,1SPHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized conserved protein (DUF2249) - - - - - - - - - - - - DUF2249,Hemerythrin MMS2_k127_717289_6 1502852.FG94_01892 2.812e-36 142.0 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,474VE@75682|Oxalobacteraceae 28216|Betaproteobacteria S Invasion gene expression up-regulator, SirB sirB - - - - - - - - - - - SirB MMS2_k127_717289_2 1408418.JNJH01000030_gene2357 1.141e-80 272.0 COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,2TRTH@28211|Alphaproteobacteria,2JQFW@204441|Rhodospirillales 204441|Rhodospirillales FH Permease for cytosine/purines, uracil, thiamine, allantoin - - - ko:K03457 - - - - ko00000 2.A.39 - - Transp_cyt_pur MMS2_k127_745147_3 1116375.VEJY3_04225 7.082e-143 454.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1XT2A@135623|Vibrionales 135623|Vibrionales O Peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_3 MMS2_k127_745147_4 713586.KB900536_gene1837 5.695e-56 201.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1WWA2@135613|Chromatiales 135613|Chromatiales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI MMS2_k127_745147_2 713586.KB900536_gene1838 3.366e-159 508.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales 135613|Chromatiales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase MMS2_k127_745147_1 519989.ECTPHS_11822 2.061e-170 542.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales 135613|Chromatiales F Belongs to the dGTPase family. Type 2 subfamily - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc MMS2_k127_745147_0 396588.Tgr7_3033 0.0 1241.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase MMS2_k127_755824_8 637390.AFOH01000012_gene683 1.692e-21 99.0 COG5622@1|root,COG5622@2|Bacteria 2|Bacteria N Protein required for attachment to host cells - - - - - - - - - - - - Host_attach MMS2_k127_755824_7 1172188.KB911830_gene3825 2.968e-44 171.0 arCOG03842@1|root,30WW9@2|Bacteria,2IDJ1@201174|Actinobacteria,4FFCN@85021|Intrasporangiaceae 201174|Actinobacteria S Domain of unknown function (DUF929) - - - - - - - - - - - - DUF929 MMS2_k127_755824_1 870187.Thini_1259 3.236e-138 451.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,45ZST@72273|Thiotrichales 72273|Thiotrichales H MoeA N-terminal region (domain I and II) - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N MMS2_k127_755824_6 396588.Tgr7_2131 1.026e-62 226.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1WY0J@135613|Chromatiales 135613|Chromatiales H molybdopterin-guanine dinucleotide biosynthesis protein mobB - - ko:K03753 - - - - ko00000 - - - MobB MMS2_k127_755824_2 713586.KB900536_gene934 5.963e-133 436.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales 135613|Chromatiales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD MMS2_k127_755824_4 626887.J057_06976 1.747e-104 344.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,464MH@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA - - - - - - - - - - - Band_7 MMS2_k127_755824_3 396588.Tgr7_2127 6.007e-121 399.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1WW40@135613|Chromatiales 135613|Chromatiales L TIGRFAM Tyrosine recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase MMS2_k127_755824_5 713586.KB900536_gene931 1.5e-64 231.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales 135613|Chromatiales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 MMS2_k127_755824_9 579405.Dd703_2445 3.628e-21 95.0 COG2207@1|root,COG2207@2|Bacteria,1PGAM@1224|Proteobacteria,1RXNS@1236|Gammaproteobacteria,2JDUP@204037|Dickeya 1236|Gammaproteobacteria K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 MMS2_k127_755824_0 1163617.SCD_n00655 2.033e-266 831.0 COG2509@1|root,COG2509@2|Bacteria,1MV6P@1224|Proteobacteria,2VHGJ@28216|Betaproteobacteria 28216|Betaproteobacteria S fad dependent oxidoreductase - - - ko:K07137 - - - - ko00000 - - - Amino_oxidase,Pyr_redox_2 MMS2_k127_755824_10 1120985.AUMI01000016_gene1840 3.27e-19 88.0 COG0454@1|root,COG0456@2|Bacteria,1V8UP@1239|Firmicutes,4H4QH@909932|Negativicutes 909932|Negativicutes K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 MMS2_k127_765933_2 1123256.KB907926_gene970 8.878e-69 244.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1X36H@135614|Xanthomonadales 135614|Xanthomonadales J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA MMS2_k127_765933_1 1123393.KB891332_gene2836 3.071e-135 458.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3 MMS2_k127_765933_0 396588.Tgr7_0696 4.731e-152 490.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase MMS2_k127_77428_4 1286631.X805_21600 3.413e-16 81.0 COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2VI5K@28216|Betaproteobacteria,1KJIB@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Eukaryotic-type carbonic anhydrase cah - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase,VPEP MMS2_k127_77428_2 351746.Pput_3458 1.869e-89 302.0 COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,1YUZJ@136845|Pseudomonas putida group 1236|Gammaproteobacteria L PFAM TatD-related deoxyribonuclease tatD GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase MMS2_k127_77428_0 1123368.AUIS01000009_gene2455 0.0 1120.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,2NC0P@225057|Acidithiobacillales 225057|Acidithiobacillales E Domain of unknown function (DUF3458_C) ARM repeats pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 MMS2_k127_77428_3 713587.THITH_08560 4.135e-28 117.0 2E8UR@1|root,33355@2|Bacteria,1MYPY@1224|Proteobacteria,1S6SI@1236|Gammaproteobacteria,1WYQ0@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - MMS2_k127_77428_1 754476.Q7A_493 1.424e-176 568.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,45ZXR@72273|Thiotrichales 72273|Thiotrichales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM MMS2_k127_845944_6 1169143.KB911049_gene5588 5.948e-145 469.0 COG0701@1|root,COG0701@2|Bacteria,1NC9F@1224|Proteobacteria,2W8MG@28216|Betaproteobacteria,1K1P0@119060|Burkholderiaceae 28216|Betaproteobacteria S Predicted permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 MMS2_k127_845944_23 1380358.JADJ01000011_gene207 1.518e-44 170.0 COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,1T0ZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase MMS2_k127_845944_21 465541.ATCJ01000005_gene7226 2.785e-46 176.0 COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria 201174|Actinobacteria S hydrolase - - - - - - - - - - - - HAD_2 MMS2_k127_845944_17 452637.Oter_1378 1.126e-61 225.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds yobB - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase MMS2_k127_845944_22 1499967.BAYZ01000118_gene3252 2.243e-45 181.0 COG0662@1|root,COG0662@2|Bacteria,2NRIV@2323|unclassified Bacteria 2|Bacteria G Cupin domain - - - - - - - - - - - - Cupin_2 MMS2_k127_845944_25 177439.DP2485 4.35e-33 138.0 COG2350@1|root,COG2350@2|Bacteria,1N8AZ@1224|Proteobacteria,42V5N@68525|delta/epsilon subdivisions,2WWPC@28221|Deltaproteobacteria 28221|Deltaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII MMS2_k127_845944_20 1211114.ALIP01000099_gene1905 1.273e-46 172.0 COG1942@1|root,COG1942@2|Bacteria,1N2V3@1224|Proteobacteria,1SFKB@1236|Gammaproteobacteria,1XC4N@135614|Xanthomonadales 135614|Xanthomonadales S Tautomerase enzyme - - - - - - - - - - - - Tautomerase_2 MMS2_k127_845944_9 1042326.AZNV01000022_gene879 1.115e-110 366.0 COG0583@1|root,COG0583@2|Bacteria,1R49T@1224|Proteobacteria,2U6BN@28211|Alphaproteobacteria,4B9MZ@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator pecT - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_845944_24 1196835.A458_08760 1.977e-38 147.0 COG3070@1|root,COG3070@2|Bacteria,1N0ND@1224|Proteobacteria,1SE8F@1236|Gammaproteobacteria,1Z310@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K COG3070 Regulator of competence-specific genes - - - - - - - - - - - - TfoX_N MMS2_k127_845944_15 272560.BPSL1736 4.452e-80 274.0 COG0500@1|root,COG2226@2|Bacteria,1MV7N@1224|Proteobacteria,2VYDC@28216|Betaproteobacteria,1K4ZK@119060|Burkholderiaceae 28216|Betaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 MMS2_k127_845944_11 266265.Bxe_C1335 1.481e-93 315.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2VRJM@28216|Betaproteobacteria,1K68C@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate MMS2_k127_845944_18 631454.N177_2114 1.086e-55 209.0 COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria,2TT4T@28211|Alphaproteobacteria,1JPWN@119043|Rhodobiaceae 28211|Alphaproteobacteria GM NmrA-like family - - - - - - - - - - - - Epimerase,NAD_binding_10 MMS2_k127_845944_26 1121403.AUCV01000056_gene3009 1.306e-32 129.0 COG2329@1|root,COG2329@2|Bacteria,1RHK9@1224|Proteobacteria,43EGV@68525|delta/epsilon subdivisions,2X8BK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - - MMS2_k127_845944_13 748280.NH8B_0747 1.79e-89 302.0 COG0504@1|root,COG0504@2|Bacteria,1QBV2@1224|Proteobacteria 1224|Proteobacteria F CTP synthase pyrG2 - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - GATase MMS2_k127_845944_19 1026882.MAMP_00536 2.373e-50 186.0 COG2258@1|root,COG2258@2|Bacteria,1NCM2@1224|Proteobacteria,1S7UM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - MOSC MMS2_k127_845944_12 264198.Reut_A3399 4.517e-91 303.0 COG1280@1|root,COG1280@2|Bacteria,1RA1G@1224|Proteobacteria,2VKHI@28216|Betaproteobacteria 28216|Betaproteobacteria E Lysine exporter protein (Lyse ygga) - - - ko:K11250 - - - - ko00000,ko02000 2.A.76.1.5 - - LysE MMS2_k127_845944_3 717785.HYPMC_1410 3.708e-165 526.0 COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TUI2@28211|Alphaproteobacteria,3N8AD@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 MMS2_k127_845944_10 1122929.KB908220_gene2758 1.201e-108 357.0 COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Family of unknown function (DUF1028) MA20_16755 - - - - - - - - - - - DUF1028 MMS2_k127_845944_0 1509405.GV67_13380 3.26e-322 992.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TSME@28211|Alphaproteobacteria,4BCI0@82115|Rhizobiaceae 28211|Alphaproteobacteria E gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept MMS2_k127_845944_5 384765.SIAM614_01691 3.469e-146 476.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EP ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N MMS2_k127_845944_4 936136.ARRT01000006_gene5547 1.995e-160 510.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,4B8W1@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 MMS2_k127_845944_2 384765.SIAM614_01701 6.997e-228 715.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 MMS2_k127_845944_8 384765.SIAM614_01706 1.439e-136 459.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS2_k127_845944_7 1336243.JAEA01000014_gene3641 6.767e-137 443.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,1JR8B@119045|Methylobacteriaceae 28211|Alphaproteobacteria EP Belongs to the ABC transporter superfamily dppD - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY MMS2_k127_845944_14 936136.ARRT01000006_gene5545 2.006e-84 286.0 COG2186@1|root,COG2186@2|Bacteria,1R90B@1224|Proteobacteria,2VF47@28211|Alphaproteobacteria,4BN6S@82115|Rhizobiaceae 28211|Alphaproteobacteria K FCD - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR MMS2_k127_845944_16 944435.AXAJ01000012_gene2970 4.07e-66 230.0 COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,1K1C3@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 MMS2_k127_845944_1 748280.NH8B_2766 8.755e-315 978.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria 28216|Betaproteobacteria L DEAD DEAH box helicase lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C MMS2_k127_864388_0 1454004.AW11_02009 0.0 1258.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria 28216|Betaproteobacteria P Pfam Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase MMS2_k127_864388_1 1122214.AQWH01000003_gene4062 5.441e-161 515.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2PKRY@255475|Aurantimonadaceae 28211|Alphaproteobacteria E Cobalamin-independent synthase, Catalytic domain MA20_32395 - 2.1.1.14,4.4.1.23 ko:K00549,ko:K22363 ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230 M00017 R04405,R09365,R11897,R11899 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 MMS2_k127_864388_2 1294143.H681_05515 1.335e-18 85.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPGB@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N MMS2_k127_864936_0 561229.Dd1591_3424 5.761e-201 644.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,2JCI0@204037|Dickeya 1236|Gammaproteobacteria L single-stranded-DNA-specific exonuclease RecJ recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 MMS2_k127_864936_3 519989.ECTPHS_03647 5.716e-29 130.0 COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,1S23W@1236|Gammaproteobacteria,1WY5V@135613|Chromatiales 135613|Chromatiales S protein conserved in bacteria - - - - - - - - - - - - - MMS2_k127_864936_1 266117.Rxyl_0487 9.144e-90 302.0 COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4CQ1B@84995|Rubrobacteria 84995|Rubrobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 MMS2_k127_864936_2 519989.ECTPHS_10029 1.094e-77 271.0 COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales 135613|Chromatiales CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C MMS2_k127_885054_3 1163407.UU7_08373 1.254e-55 199.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1X4J6@135614|Xanthomonadales 135614|Xanthomonadales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 MMS2_k127_885054_4 1163408.UU9_07813 2.753e-07 52.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1X6QS@135614|Xanthomonadales 135614|Xanthomonadales C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 MMS2_k127_885054_0 1163408.UU9_07813 1.789e-97 329.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1X6QS@135614|Xanthomonadales 135614|Xanthomonadales C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_8 MMS2_k127_885054_1 1234364.AMSF01000060_gene962 6.455e-76 258.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1X61V@135614|Xanthomonadales 135614|Xanthomonadales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 MMS2_k127_885054_2 1500890.JQNL01000001_gene1507 1.574e-67 231.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1X64V@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 ## 2468 queries scanned ## Total time (seconds): 72.89521956443787 ## Rate: 33.86 q/s