## Wed Feb 18 01:37:30 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/MMS2_bin.56.fa -m mmseqs --output MMS2_bin.56 --output_dir /data/result/bins/wyx/eggqs50+/MMS2_bin.56 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS2_k127_1000647_1	357804.Ping_3731	1.291e-14	80.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,2QHIZ@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
MMS2_k127_1000647_0	86416.Clopa_4379	5.84e-74	253.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,36ERS@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_1006959_1	1009370.ALO_18752	8.262e-23	104.0	COG0535@1|root,COG2327@1|root,COG0535@2|Bacteria,COG2327@2|Bacteria	2|Bacteria	S	slime layer polysaccharide biosynthetic process	-	-	-	ko:K16710	-	-	-	-	ko00000	-	-	-	PS_pyruv_trans,Radical_SAM
MMS2_k127_1006959_0	1123373.ATXI01000034_gene1162	8.613e-32	130.0	COG2264@1|root,COG2264@2|Bacteria,2GI9K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS2_k127_1013353_1	293826.Amet_1270	1.416e-06	52.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
MMS2_k127_1013353_2	886379.AEWI01000008_gene683	0.0001063	47.0	COG4980@1|root,COG4980@2|Bacteria,4NXHU@976|Bacteroidetes,2G1Z2@200643|Bacteroidia,3XKC6@558415|Marinilabiliaceae	976|Bacteroidetes	S	YtxH-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YtxH
MMS2_k127_1013353_0	398512.JQKC01000002_gene1871	7.426e-68	241.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,3WI13@541000|Ruminococcaceae	186801|Clostridia	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
MMS2_k127_1024548_1	445971.ANASTE_01808	4.198e-19	89.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,25V72@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
MMS2_k127_1024548_2	1410618.JNKI01000003_gene2457	1.023e-14	79.0	COG0517@1|root,COG0517@2|Bacteria,1VA1X@1239|Firmicutes,4H57A@909932|Negativicutes	909932|Negativicutes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_1024548_0	747365.Thena_0592	4.43e-34	138.0	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,42GZF@68295|Thermoanaerobacterales	186801|Clostridia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
MMS2_k127_1050320_2	1031288.AXAA01000025_gene552	0.0004438	47.0	COG1376@1|root,COG1376@2|Bacteria,1V9XU@1239|Firmicutes,24NW6@186801|Clostridia,36KPB@31979|Clostridiaceae	186801|Clostridia	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
MMS2_k127_1050320_1	907348.TresaDRAFT_2226	2.595e-16	92.0	COG1193@1|root,COG1193@2|Bacteria,2J59D@203691|Spirochaetes	203691|Spirochaetes	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
MMS2_k127_1050320_0	574087.Acear_1443	8.651e-62	218.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WACI@53433|Halanaerobiales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
MMS2_k127_1052596_1	401526.TcarDRAFT_2123	2.821e-21	97.0	COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,4H54Q@909932|Negativicutes	909932|Negativicutes	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
MMS2_k127_1052596_0	1223521.BBJX01000013_gene490	2.934e-32	135.0	COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2VQ64@28216|Betaproteobacteria,4AC8N@80864|Comamonadaceae	28216|Betaproteobacteria	N	Role in flagellar biosynthesis	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
MMS2_k127_1052596_2	1120985.AUMI01000015_gene1679	3.966e-12	71.0	COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,4H20R@909932|Negativicutes	909932|Negativicutes	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
MMS2_k127_1060415_5	765177.Desmu_1082	6.157e-08	55.0	COG2518@1|root,arCOG00976@2157|Archaea,2XPYU@28889|Crenarchaeota	28889|Crenarchaeota	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMS2_k127_1060415_3	330214.NIDE4284	7.955e-32	133.0	COG0546@1|root,COG0546@2|Bacteria,3J0QE@40117|Nitrospirae	40117|Nitrospirae	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS2_k127_1060415_4	999419.HMPREF1077_00495	9.751e-14	73.0	COG1141@1|root,COG1141@2|Bacteria,4P7D9@976|Bacteroidetes,2FZ83@200643|Bacteroidia	976|Bacteroidetes	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
MMS2_k127_1060415_2	316067.Geob_3294	8.763e-89	297.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the WrbA family	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
MMS2_k127_1060415_0	381764.Fnod_0055	3.354e-179	578.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GC9M@200918|Thermotogae	200918|Thermotogae	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	POR,POR_N
MMS2_k127_1060415_1	1231241.Mc24_05740	1.484e-112	367.0	COG1013@1|root,COG1013@2|Bacteria,2GCNG@200918|Thermotogae	200918|Thermotogae	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS2_k127_1061058_0	635013.TherJR_0831	2.668e-151	488.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,2609N@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMS2_k127_1066848_0	521460.Athe_0393	2.326e-253	793.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
MMS2_k127_1066848_1	880073.Calab_0942	6.297e-49	181.0	COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
MMS2_k127_1070525_0	526218.Sterm_3095	6.634e-53	190.0	COG0451@1|root,COG0451@2|Bacteria,379DD@32066|Fusobacteria	32066|Fusobacteria	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
MMS2_k127_107298_2	944479.JQLX01000015_gene46	3.226e-34	135.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M6GY@213113|Desulfurellales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
MMS2_k127_107298_3	398512.JQKC01000038_gene4576	1.15e-24	105.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3WKI1@541000|Ruminococcaceae	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
MMS2_k127_107298_0	324602.Caur_3763	2.77e-55	203.0	COG1216@1|root,COG1216@2|Bacteria,2G7UG@200795|Chloroflexi,3764Q@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
MMS2_k127_107298_1	186497.PF0058	3.501e-54	198.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMS2_k127_107912_1	1460635.JCM19038_3616	1.893e-05	50.0	COG1216@1|root,COG1216@2|Bacteria,1TQTM@1239|Firmicutes,4IQ0W@91061|Bacilli	91061|Bacilli	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_107912_0	1009370.ALO_19347	3.18e-34	148.0	COG0859@1|root,COG0859@2|Bacteria,1UZZI@1239|Firmicutes,4H2VC@909932|Negativicutes	909932|Negativicutes	M	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
MMS2_k127_1099654_0	525903.Taci_1337	2.915e-47	182.0	COG1766@1|root,COG1766@2|Bacteria,3T9SX@508458|Synergistetes	508458|Synergistetes	N	The M ring may be actively involved in energy transduction	-	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
MMS2_k127_1099654_2	555079.Toce_1094	2.92e-05	51.0	COG1677@1|root,COG1677@2|Bacteria,1VEEY@1239|Firmicutes,259BT@186801|Clostridia,42H83@68295|Thermoanaerobacterales	186801|Clostridia	N	Flagellar hook-basal body complex protein FliE	fliE	-	-	ko:K02408	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliE
MMS2_k127_1099654_1	373903.Hore_16910	4.397e-36	141.0	COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,3WBUF@53433|Halanaerobiales	186801|Clostridia	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
MMS2_k127_110131_0	1304880.JAGB01000001_gene276	1.256e-75	264.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia	186801|Clostridia	S	Conserved protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
MMS2_k127_110131_1	340099.Teth39_1082	9.582e-28	115.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,42FBI@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
MMS2_k127_1109617_1	1120985.AUMI01000015_gene1656	1.688e-129	422.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,4H2VM@909932|Negativicutes	909932|Negativicutes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
MMS2_k127_1109617_0	1123376.AUIU01000016_gene293	3.709e-164	526.0	COG0015@1|root,COG0015@2|Bacteria,3J0EM@40117|Nitrospirae	40117|Nitrospirae	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMS2_k127_111278_1	1232410.KI421418_gene2422	3.408e-55	194.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,43VZ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	SelR domain	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS2_k127_111278_0	755731.Clo1100_1836	5.526e-94	321.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS2_k127_1116938_1	1235790.C805_00125	6.35e-06	55.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,25WJZ@186806|Eubacteriaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
MMS2_k127_1116938_0	638302.HMPREF0908_1717	2.074e-106	351.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,4H2EY@909932|Negativicutes	909932|Negativicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
MMS2_k127_112137_0	1232437.KL661969_gene4957	4.16e-64	237.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS2_k127_1144437_1	311424.DhcVS_1511	5.041e-41	153.0	COG1032@1|root,COG1032@2|Bacteria,2G5N0@200795|Chloroflexi,34CUW@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS2_k127_1144437_0	935948.KE386494_gene340	1.187e-290	907.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42ER6@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
MMS2_k127_1160671_2	391612.CY0110_13052	1.988e-25	108.0	COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,3KG7C@43988|Cyanothece	1117|Cyanobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS2_k127_1160671_1	760568.Desku_0437	5.572e-26	109.0	COG0724@1|root,COG0724@2|Bacteria,1VBMH@1239|Firmicutes,24NVR@186801|Clostridia,262F2@186807|Peptococcaceae	186801|Clostridia	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
MMS2_k127_1160671_0	575540.Isop_3507	1.044e-68	241.0	COG0535@1|root,COG0535@2|Bacteria,2IXC0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
MMS2_k127_1161252_0	574087.Acear_1870	1.04e-141	462.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WBGE@53433|Halanaerobiales	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
MMS2_k127_1161252_1	298654.FraEuI1c_1961	0.0008134	46.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4ERRX@85013|Frankiales	201174|Actinobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
MMS2_k127_1172693_1	1121017.AUFG01000007_gene1236	6.612e-05	46.0	COG1208@1|root,COG1208@2|Bacteria,2GKHA@201174|Actinobacteria,4FJ2Q@85021|Intrasporangiaceae	201174|Actinobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
MMS2_k127_1172693_0	338966.Ppro_3397	9.596e-25	107.0	COG0030@1|root,COG0030@2|Bacteria	2|Bacteria	J	rRNA (adenine-N6,N6-)-dimethyltransferase activity	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528,ko:K15256	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009,ko03016	-	-	-	Methyltransf_21,Methyltransf_25,RrnaAD
MMS2_k127_1185632_0	671143.DAMO_0297	1.872e-66	241.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
MMS2_k127_1192004_1	1536774.H70357_27250	1.26e-77	282.0	COG0395@1|root,COG0395@2|Bacteria,1TSEP@1239|Firmicutes,4HF79@91061|Bacilli,276GM@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS2_k127_1192004_0	1094508.Tsac_2257	4.001e-113	372.0	COG1175@1|root,COG1175@2|Bacteria,1UZ3K@1239|Firmicutes,24F6X@186801|Clostridia,42J20@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS2_k127_124122_1	689781.AUJX01000009_gene324	8.126e-23	100.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,2PTYR@265975|Oribacterium	186801|Clostridia	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
MMS2_k127_124122_0	167550.EV00_1099	1.347e-55	202.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_124122_2	167542.P9515_14021	3.311e-10	63.0	COG1208@1|root,COG1208@2|Bacteria	2|Bacteria	JM	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
MMS2_k127_124186_0	643648.Slip_0973	1.136e-59	214.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,42JMN@68298|Syntrophomonadaceae	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
MMS2_k127_124186_1	926692.AZYG01000096_gene1896	1.199e-06	61.0	29X6V@1|root,30IW1@2|Bacteria,1VY2J@1239|Firmicutes,251WA@186801|Clostridia,3WBY0@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_127096_2	1382358.JHVN01000001_gene751	2.329e-27	121.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,4HA6Q@91061|Bacilli,21VH5@150247|Anoxybacillus	91061|Bacilli	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMS2_k127_127096_1	1230342.CTM_12740	4.978e-40	156.0	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,36I39@31979|Clostridiaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMS2_k127_127096_0	1408423.JHYA01000001_gene1108	2.788e-43	164.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,4H3BM@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_1276710_0	545695.TREAZ_3555	1.161e-11	78.0	COG2885@1|root,COG2885@2|Bacteria,2J5KD@203691|Spirochaetes	203691|Spirochaetes	M	ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_3,CHU_C,FlgD_ig,OmpA
MMS2_k127_127702_1	340099.Teth39_1539	1.017e-79	278.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,42FCC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
MMS2_k127_127702_0	289376.THEYE_A1533	2.389e-126	411.0	COG2256@1|root,COG2256@2|Bacteria,3J0H6@40117|Nitrospirae	40117|Nitrospirae	L	MgsA AAA+ ATPase C terminal	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA_assoc_2,MgsA_C,RuvB_N
MMS2_k127_1285812_0	883156.HMPREF9282_01313	3.752e-88	300.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,4H2JQ@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
MMS2_k127_1291431_0	373903.Hore_03200	6.366e-118	387.0	COG0825@1|root,COG0825@2|Bacteria,1UHNS@1239|Firmicutes,25E47@186801|Clostridia,3WB53@53433|Halanaerobiales	186801|Clostridia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
MMS2_k127_1291431_1	1121918.ARWE01000001_gene2325	8.942e-102	339.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,42MAB@68525|delta/epsilon subdivisions,2WK95@28221|Deltaproteobacteria,43S80@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
MMS2_k127_1291431_2	218284.CCDN010000001_gene726	6.464e-06	51.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,4HNJS@91061|Bacilli,1ZI3X@1386|Bacillus	91061|Bacilli	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
MMS2_k127_1294556_0	574087.Acear_1298	3.195e-251	794.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,3WAD9@53433|Halanaerobiales	186801|Clostridia	S	PFAM Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
MMS2_k127_1294556_1	1304888.ATWF01000001_gene659	1.044e-67	235.0	COG0505@1|root,COG0505@2|Bacteria,2GF07@200930|Deferribacteres	200930|Deferribacteres	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
MMS2_k127_1295332_0	247490.KSU1_C1352	3.212e-117	388.0	COG2204@1|root,COG2204@2|Bacteria,2IYIG@203682|Planctomycetes	203682|Planctomycetes	T	CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS2_k127_129638_0	1200792.AKYF01000011_gene3807	6.279e-07	63.0	COG4106@1|root,COG4106@2|Bacteria,1V188@1239|Firmicutes,4HENY@91061|Bacilli,26V4Q@186822|Paenibacillaceae	91061|Bacilli	S	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
MMS2_k127_1310363_0	443254.Marpi_0767	1.148e-18	102.0	COG5276@1|root,COG5276@2|Bacteria,2GD6R@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin, type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1336325_0	1280952.HJA_04691	4.828e-15	88.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,2TRSN@28211|Alphaproteobacteria,43WWJ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	protein involved in outer membrane biogenesis	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
MMS2_k127_1343470_4	658088.HMPREF0987_01772	5.261e-13	77.0	COG0145@1|root,COG0145@2|Bacteria,1V3BH@1239|Firmicutes,24H6U@186801|Clostridia,27RUW@186928|unclassified Lachnospiraceae	186801|Clostridia	EQ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1343470_3	357809.Cphy_3245	5.543e-31	130.0	COG3010@1|root,COG3010@2|Bacteria,1V928@1239|Firmicutes,24EJW@186801|Clostridia,220VZ@1506553|Lachnoclostridium	186801|Clostridia	G	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1343470_2	335541.Swol_1430	6.974e-45	167.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,42JZ1@68298|Syntrophomonadaceae	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
MMS2_k127_1343470_1	1121422.AUMW01000003_gene928	4.842e-107	361.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,2607M@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS2_k127_1343470_0	309799.DICTH_0731	3.934e-261	819.0	COG0556@1|root,COG0556@2|Bacteria	2|Bacteria	L	nucleotide-excision repair	uvrB	GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006950,GO:0008150,GO:0009314,GO:0009380,GO:0009605,GO:0009607,GO:0009628,GO:0016020,GO:0032991,GO:0035821,GO:0042802,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
MMS2_k127_1343960_1	1382304.JNIL01000001_gene667	4.346e-13	71.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
MMS2_k127_1343960_0	1499967.BAYZ01000158_gene430	1.369e-46	176.0	COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria	2|Bacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
MMS2_k127_1345581_1	1408422.JHYF01000020_gene1806	1.204e-43	164.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,36EIP@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
MMS2_k127_1345581_2	1449126.JQKL01000010_gene458	6.703e-35	138.0	COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,24MV7@186801|Clostridia,268Z4@186813|unclassified Clostridiales	186801|Clostridia	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
MMS2_k127_1345581_0	246194.CHY_1985	6.045e-72	246.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,42EPX@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
MMS2_k127_1363399_0	316067.Geob_0631	4.092e-54	199.0	COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2WK22@28221|Deltaproteobacteria,43TZ1@69541|Desulfuromonadales	28221|Deltaproteobacteria	N	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation	flgI	-	-	ko:K02394	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgI
MMS2_k127_1363399_1	555079.Toce_1125	1.385e-23	109.0	COG1191@1|root,COG1191@2|Bacteria,1TP9K@1239|Firmicutes,248M0@186801|Clostridia,42GJB@68295|Thermoanaerobacterales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS2_k127_1371707_1	350688.Clos_0007	4.04e-108	353.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,36E5Z@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS2_k127_1371707_0	871968.DESME_00030	1.916e-246	777.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,260WQ@186807|Peptococcaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS2_k127_1371707_3	1392502.JNIO01000007_gene975	1.131e-07	57.0	COG5512@1|root,COG5512@2|Bacteria,1V9FF@1239|Firmicutes,4H4RR@909932|Negativicutes	909932|Negativicutes	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
MMS2_k127_1371707_2	574087.Acear_0002	2.397e-10	63.0	COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,3WA84@53433|Halanaerobiales	186801|Clostridia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
MMS2_k127_1377909_0	1445613.JALM01000104_gene6296	1.78e-118	388.0	COG2089@1|root,COG2089@2|Bacteria,2GJC9@201174|Actinobacteria,4E2Q9@85010|Pseudonocardiales	201174|Actinobacteria	M	TIGRFAM pseudaminic acid synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
MMS2_k127_1377909_1	208439.AJAP_01295	9.758e-16	81.0	COG1670@1|root,COG1670@2|Bacteria,2GUD3@201174|Actinobacteria,4E6UW@85010|Pseudonocardiales	201174|Actinobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_139385_0	1379698.RBG1_1C00001G0687	7.409e-119	396.0	COG1109@1|root,COG1109@2|Bacteria,2NNM3@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	glmM	-	5.4.2.10,5.4.2.2,5.4.2.8	ko:K01840,ko:K03431,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R02060,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS2_k127_139385_2	555079.Toce_2078	1.146e-63	227.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,42EU7@68295|Thermoanaerobacterales	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
MMS2_k127_139385_3	697281.Mahau_1517	9.915e-54	193.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,42EU7@68295|Thermoanaerobacterales	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
MMS2_k127_139385_1	1121430.JMLG01000002_gene1072	8.2e-109	362.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,2602H@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS2_k127_141661_1	1128427.KB904821_gene726	3.225e-12	80.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G36K@1117|Cyanobacteria,1H9PH@1150|Oscillatoriales	1117|Cyanobacteria	O	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,TPR_1,TPR_11,TPR_2,TPR_4,TPR_8,Trypsin_2
MMS2_k127_141661_3	457570.Nther_2921	0.0003543	54.0	COG0457@1|root,COG0457@2|Bacteria	457570.Nther_2921|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_141661_0	748449.Halha_2435	2.531e-77	271.0	COG0795@1|root,COG0795@2|Bacteria,1UZNX@1239|Firmicutes,24F8X@186801|Clostridia,3WAEC@53433|Halanaerobiales	186801|Clostridia	M	Permease YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
MMS2_k127_141661_2	985762.SAGN_02995	3.269e-07	53.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,4HNPV@91061|Bacilli,4GZXG@90964|Staphylococcaceae	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
MMS2_k127_1438669_3	1410638.JHXJ01000008_gene393	3.558e-28	116.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3WICZ@541000|Ruminococcaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMS2_k127_1438669_2	926566.Terro_3707	4.841e-29	118.0	COG0256@1|root,COG0256@2|Bacteria,3Y5CH@57723|Acidobacteria,2JJPM@204432|Acidobacteriia	204432|Acidobacteriia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
MMS2_k127_1438669_0	1219581.HMPREF1628_01360	4.391e-56	201.0	COG0097@1|root,COG0097@2|Bacteria,2GK35@201174|Actinobacteria,4D3X4@85005|Actinomycetales	201174|Actinobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMS2_k127_1438669_1	457405.FSDG_01715	7.551e-32	128.0	COG0096@1|root,COG0096@2|Bacteria,379ZT@32066|Fusobacteria	32066|Fusobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMS2_k127_1481191_2	646529.Desaci_1033	1.523e-12	69.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,260S2@186807|Peptococcaceae	186801|Clostridia	GK	pfam rok	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMS2_k127_1481191_1	696281.Desru_1293	2.303e-64	227.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
MMS2_k127_1481191_0	255470.cbdbA1278	2.958e-75	259.0	COG0106@1|root,COG0106@2|Bacteria,2G6EC@200795|Chloroflexi,34CVB@301297|Dehalococcoidia	301297|Dehalococcoidia	E	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	hisA	GO:0000105,GO:0003674,GO:0003824,GO:0003949,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMS2_k127_1494312_0	86106.I862_02570	4.86e-31	124.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,47FC5@766|Rickettsiales	766|Rickettsiales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
MMS2_k127_149652_2	159087.Daro_0883	5.627e-12	69.0	COG2165@1|root,COG2165@2|Bacteria,1N7HN@1224|Proteobacteria,2VUSU@28216|Betaproteobacteria,2KX3S@206389|Rhodocyclales	206389|Rhodocyclales	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K10924	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
MMS2_k127_149652_1	760142.Hipma_1131	5.236e-93	319.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2M7KS@213113|Desulfurellales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K02653,ko:K12278	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
MMS2_k127_149652_0	401526.TcarDRAFT_1563	3.195e-146	476.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4H2AT@909932|Negativicutes	909932|Negativicutes	NU	Type II IV secretion system protein	epsE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
MMS2_k127_15053_1	697281.Mahau_1498	4.125e-64	228.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,42EM6@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS2_k127_15053_2	224324.aq_1853	6.773e-50	184.0	COG1994@1|root,COG1994@2|Bacteria,2G44C@200783|Aquificae	200783|Aquificae	S	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS2_k127_15053_0	1235801.C822_00211	4.6e-78	271.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HAEX@91061|Bacilli,3F3V9@33958|Lactobacillaceae	91061|Bacilli	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMS2_k127_1516163_0	272562.CA_C0713	2.943e-174	559.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,36ET7@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMS2_k127_1516163_1	675806.VII_000619	1.106e-09	61.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1XWCF@135623|Vibrionales	135623|Vibrionales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_1526510_1	521460.Athe_1475	2.022e-13	72.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,42G87@68295|Thermoanaerobacterales	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
MMS2_k127_1526510_0	373903.Hore_16050	1.813e-80	277.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WB29@53433|Halanaerobiales	186801|Clostridia	GK	TIGRFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
MMS2_k127_1527064_0	429009.Adeg_2059	1.399e-198	629.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,42EN9@68295|Thermoanaerobacterales	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
MMS2_k127_1527064_1	484770.UFO1_4407	1.151e-78	272.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,4H2FM@909932|Negativicutes	909932|Negativicutes	E	Glutamate formiminotransferase	-	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
MMS2_k127_1527064_2	330214.NIDE2674	1.584e-33	138.0	COG0614@1|root,COG0614@2|Bacteria,3J173@40117|Nitrospirae	40117|Nitrospirae	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS2_k127_1550130_3	926692.AZYG01000051_gene1869	2.926e-11	64.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,3WAEH@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
MMS2_k127_1550130_1	926692.AZYG01000036_gene2551	6.757e-51	202.0	COG4206@1|root,COG4206@2|Bacteria,1V287@1239|Firmicutes,24SUD@186801|Clostridia,3WB9E@53433|Halanaerobiales	186801|Clostridia	H	TonB-dependent Receptor Plug	-	-	-	ko:K02014,ko:K16089	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.1,1.B.14.10	-	-	Plug,TonB_dep_Rec
MMS2_k127_1550130_2	479434.Sthe_0443	1.62e-16	81.0	2A4D2@1|root,30SYV@2|Bacteria,2G7DH@200795|Chloroflexi,27YNF@189775|Thermomicrobia	189775|Thermomicrobia	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
MMS2_k127_1550130_0	1280688.AUJB01000008_gene756	1.332e-105	351.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3NGTN@46205|Pseudobutyrivibrio	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMS2_k127_1565389_0	1047013.AQSP01000098_gene2573	1.861e-52	189.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_1565389_2	1246484.D479_16439	8.074e-08	62.0	COG1310@1|root,COG1310@2|Bacteria,1VDHV@1239|Firmicutes,4ICYE@91061|Bacilli,3NFAC@45667|Halobacillus	91061|Bacilli	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
MMS2_k127_1565389_1	1209989.TepiRe1_2120	1.482e-31	129.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,42EN1@68295|Thermoanaerobacterales	186801|Clostridia	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMS2_k127_1583133_0	1121438.JNJA01000011_gene1826	5.323e-16	79.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria	1224|Proteobacteria	M	Pfam Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
MMS2_k127_1583133_1	665942.HMPREF1022_02157	0.0005751	51.0	2F89T@1|root,340P0@2|Bacteria,1NX7H@1224|Proteobacteria,436M4@68525|delta/epsilon subdivisions,2X18C@28221|Deltaproteobacteria,2MEGH@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_160329_0	697281.Mahau_2357	7.646e-144	473.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
MMS2_k127_1610221_1	656519.Halsa_0562	4.405e-95	321.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,3WBCD@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
MMS2_k127_1610221_0	56107.Cylst_1023	1.139e-134	439.0	COG0436@1|root,COG0436@2|Bacteria,1G0X8@1117|Cyanobacteria,1HKEB@1161|Nostocales	1117|Cyanobacteria	E	PFAM Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iJN678.aspC	Aminotran_1_2
MMS2_k127_1610221_2	273068.TTE1672	1.027e-53	194.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,42EQR@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,LIAS_N,Radical_SAM
MMS2_k127_1618709_1	1511.CLOST_2311	6.823e-61	213.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,25QGI@186804|Peptostreptococcaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
MMS2_k127_1618709_0	1121428.DESHY_110566___1	4.566e-66	248.0	2DBE5@1|root,2Z8QQ@2|Bacteria,1TPFD@1239|Firmicutes,24E93@186801|Clostridia,264AU@186807|Peptococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1622861_2	498761.HM1_2194	4.668e-21	96.0	COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia	186801|Clostridia	S	cytoplasmic domain of flagellar protein FhlB	flhB1	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
MMS2_k127_1622861_1	309801.trd_A0044	4.04e-30	128.0	COG4786@1|root,COG4786@2|Bacteria,2GB75@200795|Chloroflexi,27XM0@189775|Thermomicrobia	189775|Thermomicrobia	N	Flagellar basal body rod FlgEFG protein C-terminal	-	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
MMS2_k127_1622861_0	694431.DESACE_04530	1.073e-62	224.0	COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,42N3R@68525|delta/epsilon subdivisions,2WJDN@28221|Deltaproteobacteria,2M6GB@213113|Desulfurellales	28221|Deltaproteobacteria	N	Flagellar basal body rod FlgEFG protein C-terminal	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
MMS2_k127_1635203_0	246194.CHY_0330	8.952e-268	843.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,42FKN@68295|Thermoanaerobacterales	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS2_k127_1635203_1	574087.Acear_2309	3.063e-104	349.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3WBGE@53433|Halanaerobiales	186801|Clostridia	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind,GATase
MMS2_k127_1639874_0	748280.NH8B_3544	1.93e-128	420.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,2KPVW@206351|Neisseriales	206351|Neisseriales	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMS2_k127_1645822_0	537007.BLAHAN_05224	3.564e-69	246.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3XZ21@572511|Blautia	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
MMS2_k127_1645822_1	1128427.KB904821_gene2524	6.155e-14	73.0	COG1314@1|root,COG1314@2|Bacteria,1G92B@1117|Cyanobacteria,1HCV7@1150|Oscillatoriales	1117|Cyanobacteria	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
MMS2_k127_1645822_2	330214.NIDE4206	7.81e-13	77.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
MMS2_k127_1645998_0	290512.Paes_1490	4.351e-78	265.0	COG3387@1|root,COG3387@2|Bacteria,1FE8X@1090|Chlorobi	1090|Chlorobi	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	DUF547,Glyco_hydro_15
MMS2_k127_1657021_0	1042163.BRLA_c030740	1.427e-76	265.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,4HAVW@91061|Bacilli,26RAP@186822|Paenibacillaceae	91061|Bacilli	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
MMS2_k127_1698649_3	56780.SYN_01400	7.609e-11	63.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2WJ67@28221|Deltaproteobacteria,2MQG5@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
MMS2_k127_1698649_1	443144.GM21_1600	6.799e-72	250.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,43UAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1885	PdxJ
MMS2_k127_1698649_2	635013.TherJR_2899	4.321e-46	170.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,261W1@186807|Peptococcaceae	186801|Clostridia	G	PFAM Ribose galactose isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
MMS2_k127_1698649_0	485916.Dtox_0788	3.554e-91	312.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia	186801|Clostridia	JM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
MMS2_k127_1709956_0	909663.KI867151_gene3025	2.286e-41	163.0	COG4627@1|root,COG4627@2|Bacteria,1NKXY@1224|Proteobacteria	1224|Proteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
MMS2_k127_1715984_0	1382306.JNIM01000001_gene3516	3.857e-79	271.0	COG0115@1|root,COG0115@2|Bacteria,2G5PM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS2_k127_1715984_1	696747.NIES39_M01540	1.058e-12	79.0	COG3420@1|root,COG3420@2|Bacteria,1G2FG@1117|Cyanobacteria,1H7WG@1150|Oscillatoriales	1117|Cyanobacteria	P	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1565,SLH
MMS2_k127_1716179_1	292459.STH1921	7.755e-46	168.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS2_k127_1716179_0	1121423.JONT01000001_gene2099	1.793e-129	425.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,2608E@186807|Peptococcaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS2_k127_1716179_2	1173028.ANKO01000065_gene5633	3.976e-31	137.0	COG0568@1|root,COG0568@2|Bacteria,1G1HF@1117|Cyanobacteria,1H8K2@1150|Oscillatoriales	1117|Cyanobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigB	-	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
MMS2_k127_1716179_3	96561.Dole_2664	6.884e-29	119.0	COG1661@1|root,COG1661@2|Bacteria,1NAWT@1224|Proteobacteria,42WJ4@68525|delta/epsilon subdivisions,2WRU1@28221|Deltaproteobacteria,2MNM8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMS2_k127_1717134_0	1122138.AQUZ01000065_gene4251	1.132e-74	263.0	COG1506@1|root,COG1506@2|Bacteria,2I577@201174|Actinobacteria,4DPZX@85009|Propionibacteriales	201174|Actinobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
MMS2_k127_1717134_1	247490.KSU1_C1627	1.195e-63	233.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF285,DUF5011,PKD,SBBP,UnbV_ASPIC,VCBS,fn3
MMS2_k127_175068_0	404380.Gbem_2507	4.981e-63	221.0	COG0279@1|root,COG0279@2|Bacteria,1NVIE@1224|Proteobacteria,42QUT@68525|delta/epsilon subdivisions,2X5WE@28221|Deltaproteobacteria,43W3G@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
MMS2_k127_175068_1	574087.Acear_0221	1.258e-53	194.0	COG0241@1|root,COG0241@2|Bacteria,1V6XD@1239|Firmicutes,24IZ4@186801|Clostridia	186801|Clostridia	E	D,d-heptose 1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
MMS2_k127_175068_2	868864.Dester_0640	1.785e-46	174.0	COG2870@1|root,COG2870@2|Bacteria,2G3XZ@200783|Aquificae	200783|Aquificae	M	Bifunctional protein	rfaE	-	-	-	-	-	-	-	-	-	-	-	PfkB
MMS2_k127_175331_1	985867.AEWF01000001_gene1887	1.21e-45	171.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,47F9X@766|Rickettsiales	766|Rickettsiales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
MMS2_k127_175331_0	269797.Mbar_A2815	2.613e-57	203.0	COG0225@1|root,arCOG02816@2157|Archaea,2XWKA@28890|Euryarchaeota,2N9M6@224756|Methanomicrobia	224756|Methanomicrobia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
MMS2_k127_175331_2	1094980.Mpsy_1149	2.395e-42	163.0	COG0730@1|root,arCOG06728@2157|Archaea,2XZCP@28890|Euryarchaeota,2NB0J@224756|Methanomicrobia	224756|Methanomicrobia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS2_k127_1761818_0	1449126.JQKL01000001_gene1342	4.382e-56	202.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,268V4@186813|unclassified Clostridiales	186801|Clostridia	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
MMS2_k127_1761818_1	562743.JH976435_gene2954	1.608e-21	96.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,4HC56@91061|Bacilli	91061|Bacilli	N	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliY	GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0032879,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051270,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902021,GO:2000145	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
MMS2_k127_1761818_2	1121335.Clst_0549	4.655e-06	54.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia,3WIQE@541000|Ruminococcaceae	186801|Clostridia	N	flagellar motor switch protein	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
MMS2_k127_176521_0	1303518.CCALI_01457	1.346e-170	550.0	COG0606@1|root,COG0606@2|Bacteria	2|Bacteria	O	chelatase, subunit chli	comM	-	-	ko:K06400,ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
MMS2_k127_1771129_0	1392502.JNIO01000008_gene2744	1.766e-99	329.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,4H250@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_1771129_2	720554.Clocl_3056	2.277e-48	179.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,3WJ7X@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
MMS2_k127_1771129_1	1341151.ASZU01000025_gene2998	5.81e-78	270.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,4HBBF@91061|Bacilli,27B6Y@186824|Thermoactinomycetaceae	91061|Bacilli	S	Insulinase (Peptidase family M16)	mlpA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
MMS2_k127_1780621_1	1123278.KB893389_gene4209	5.537e-18	86.0	COG0535@1|root,COG0535@2|Bacteria,4NJ4D@976|Bacteroidetes,47K2Y@768503|Cytophagia	976|Bacteroidetes	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
MMS2_k127_1780621_0	251221.35210643	2.345e-65	239.0	COG0477@1|root,COG2814@2|Bacteria,1G0DP@1117|Cyanobacteria	1117|Cyanobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_1788218_3	1007103.AFHW01000102_gene5391	2.415e-09	60.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4HH0N@91061|Bacilli,26SAP@186822|Paenibacillaceae	91061|Bacilli	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMS2_k127_1788218_0	401526.TcarDRAFT_0987	7.793e-75	258.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,4H228@909932|Negativicutes	909932|Negativicutes	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMS2_k127_1788218_1	56110.Oscil6304_5778	1.272e-58	206.0	COG0080@1|root,COG0080@2|Bacteria,1G4ZJ@1117|Cyanobacteria,1HAME@1150|Oscillatoriales	1117|Cyanobacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS2_k127_1788218_2	525904.Tter_1824	1.914e-21	96.0	COG0250@1|root,COG0250@2|Bacteria,2NPAP@2323|unclassified Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
MMS2_k127_1806775_0	1142394.PSMK_14340	4.322e-07	59.0	COG4970@1|root,COG4970@2|Bacteria,2J1P5@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
MMS2_k127_1823095_0	521045.Kole_1676	2.827e-95	316.0	COG0667@1|root,COG0667@2|Bacteria,2GBYS@200918|Thermotogae	200918|Thermotogae	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS2_k127_1823095_1	1408452.JAGZ01000003_gene4849	3.912e-09	64.0	COG2020@1|root,COG2020@2|Bacteria,2IN0C@201174|Actinobacteria,23A25@1762|Mycobacteriaceae	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
MMS2_k127_1857153_1	158190.SpiGrapes_0489	2.675e-37	145.0	COG0617@1|root,COG1078@1|root,COG0617@2|Bacteria,COG1078@2|Bacteria,2J5ZC@203691|Spirochaetes	203691|Spirochaetes	H	PolyA polymerase	papS	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
MMS2_k127_1857153_2	370438.PTH_0786	6.39e-35	146.0	COG0860@1|root,COG3103@1|root,COG3807@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,COG3807@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,260BF@186807|Peptococcaceae	186801|Clostridia	M	Cell Wall	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,CW_binding_2,Cu_amine_oxidN1,SH3_3
MMS2_k127_1857153_0	1031288.AXAA01000004_gene1953	6.296e-70	246.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
MMS2_k127_1857153_3	1256908.HMPREF0373_01368	1.026e-06	50.0	COG0720@1|root,COG0720@2|Bacteria,1VAJX@1239|Firmicutes,24JS9@186801|Clostridia,25WPS@186806|Eubacteriaceae	186801|Clostridia	H	6-pyruvoyl tetrahydropterin synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMS2_k127_187623_0	316067.Geob_3477	1.333e-82	288.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,43U7Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM penicillin-binding protein transpeptidase	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
MMS2_k127_187927_0	1123288.SOV_3c03700	9.591e-74	259.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes	909932|Negativicutes	V	lipid A export permease ATP-binding protein MsbA	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
MMS2_k127_1881236_0	56780.SYN_00357	1.076e-136	449.0	COG1351@1|root,COG1351@2|Bacteria,1QF4I@1224|Proteobacteria,43A0P@68525|delta/epsilon subdivisions,2X9Q1@28221|Deltaproteobacteria,2MSCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thymidylate synthase complementing protein	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
MMS2_k127_1881236_1	1121121.KB894287_gene3391	1.395e-05	55.0	COG1664@1|root,COG1664@2|Bacteria,1V1NS@1239|Firmicutes,4HGUF@91061|Bacilli	91061|Bacilli	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS2_k127_1885155_0	667014.Thein_0048	8.305e-64	227.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GH0E@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
MMS2_k127_1885155_1	880071.Fleli_3532	1.018e-13	74.0	COG1670@1|root,COG4106@1|root,COG1670@2|Bacteria,COG4106@2|Bacteria,4NTTP@976|Bacteroidetes,47R61@768503|Cytophagia	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,Acetyltransf_4
MMS2_k127_1893903_2	349161.Dred_1973	1.532e-76	263.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,260D7@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
MMS2_k127_1893903_3	1232430.CAVG010000118_gene1093	4.08e-52	189.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,4HFSH@91061|Bacilli,4GXQG@90964|Staphylococcaceae	91061|Bacilli	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
MMS2_k127_1893903_1	1121430.JMLG01000001_gene2165	6.584e-94	313.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,260FG@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS2_k127_1893903_5	768706.Desor_4144	5.71e-07	61.0	COG3290@1|root,COG3852@1|root,COG3290@2|Bacteria,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24C4K@186801|Clostridia,263WX@186807|Peptococcaceae	1239|Firmicutes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9
MMS2_k127_1893903_0	588581.Cpap_2074	9.09e-190	610.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3WGGQ@541000|Ruminococcaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
MMS2_k127_1893903_6	1410618.JNKI01000007_gene793	0.0005638	48.0	COG2825@1|root,COG2825@2|Bacteria,1V95M@1239|Firmicutes,4H4RT@909932|Negativicutes	909932|Negativicutes	M	PFAM Outer membrane chaperone Skp (OmpH)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
MMS2_k127_1893903_4	1408444.JHYC01000025_gene70	1.088e-21	99.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1JDN4@118969|Legionellales	118969|Legionellales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
MMS2_k127_1920721_0	635013.TherJR_1180	9.185e-39	148.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,261I9@186807|Peptococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
MMS2_k127_1935274_0	1047013.AQSP01000080_gene367	8.73e-123	412.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS2_k127_1935274_1	1047013.AQSP01000140_gene2513	5.045e-52	187.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
MMS2_k127_193741_0	1121422.AUMW01000043_gene1185	1.285e-127	421.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,260I2@186807|Peptococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS2_k127_1941094_1	997346.HMPREF9374_3920	1.024e-34	141.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,4HAPD@91061|Bacilli	91061|Bacilli	P	phosphate transporter	cysP	-	-	ko:K16331	-	-	-	-	ko00000,ko02000	2.A.20.4	-	-	PHO4
MMS2_k127_1941094_0	246194.CHY_1207	1.541e-40	160.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,42FHB@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS2_k127_1941094_2	665571.STHERM_c16140	1.28e-14	76.0	COG0007@1|root,COG0181@1|root,COG0007@2|Bacteria,COG0181@2|Bacteria,2J7WW@203691|Spirochaetes	203691|Spirochaetes	H	Uroporphyrinogen-III synthase	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Porphobil_deam,TP_methylase
MMS2_k127_1985431_0	1173021.ALWA01000008_gene1572	1.211e-70	254.0	COG0577@1|root,COG0577@2|Bacteria,1G1W4@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type antimicrobial peptide transport system, permease component	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
MMS2_k127_1985431_1	1256908.HMPREF0373_02243	4.721e-19	87.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,25VJW@186806|Eubacteriaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003,ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,FtsX
MMS2_k127_1995305_0	909663.KI867150_gene977	8.076e-76	259.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42S98@68525|delta/epsilon subdivisions,2X5D7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
MMS2_k127_1998184_0	329726.AM1_3345	1.858e-65	230.0	COG0744@1|root,COG0744@2|Bacteria,1G1XF@1117|Cyanobacteria	1117|Cyanobacteria	M	Penicillin-binding protein, 1A family	mrcB	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
MMS2_k127_1998184_2	868595.Desca_2131	9.464e-52	187.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,2621A@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
MMS2_k127_1998184_1	1183377.Py04_0946	9.147e-63	224.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,245DY@183968|Thermococci	183968|Thermococci	E	Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position	pepQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMS2_k127_1998184_3	266117.Rxyl_2176	3.667e-09	59.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4CQE7@84995|Rubrobacteria	84995|Rubrobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
MMS2_k127_2015342_0	478749.BRYFOR_08063	5.69e-34	148.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS2_k127_2084400_0	56780.SYN_00323	3.23e-79	275.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,42R1V@68525|delta/epsilon subdivisions,2WN7S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
MMS2_k127_2084400_2	1123376.AUIU01000014_gene712	7.539e-45	168.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI3	-	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DJ-1_PfpI
MMS2_k127_2084400_1	880072.Desac_2581	5.455e-49	182.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2MRF6@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMS2_k127_2087095_0	1168034.FH5T_07325	6.294e-65	224.0	COG1853@1|root,COG1853@2|Bacteria,4NF4H@976|Bacteroidetes,2FMUN@200643|Bacteroidia	976|Bacteroidetes	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMS2_k127_2087095_1	1408433.JHXV01000005_gene2462	4.137e-22	98.0	2E5WH@1|root,30K07@2|Bacteria,4P5HE@976|Bacteroidetes,1ICRB@117743|Flavobacteriia,2PBVH@246874|Cryomorphaceae	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
MMS2_k127_2093977_2	1121940.AUDZ01000013_gene820	4.013e-13	72.0	COG4123@1|root,COG4123@2|Bacteria,1QUWW@1224|Proteobacteria,1T24A@1236|Gammaproteobacteria,1XRRX@135619|Oceanospirillales	135619|Oceanospirillales	S	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
MMS2_k127_2093977_0	552811.Dehly_0384	3.41e-108	359.0	COG2021@1|root,COG2021@2|Bacteria,2G5JD@200795|Chloroflexi	200795|Chloroflexi	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
MMS2_k127_2093977_1	443143.GM18_3481	5.991e-38	143.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	metY-1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
MMS2_k127_2097962_1	643648.Slip_1490	7.308e-66	233.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,42JRX@68298|Syntrophomonadaceae	186801|Clostridia	J	B3/4 domain	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
MMS2_k127_2097962_0	1415630.U771_21690	1.68e-128	418.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iJN746.PP_2469	Phe_tRNA-synt_N,tRNA-synt_2d
MMS2_k127_2104057_0	1244869.H261_20969	4.909e-86	301.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,2TUPK@28211|Alphaproteobacteria,2JPEX@204441|Rhodospirillales	204441|Rhodospirillales	C	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
MMS2_k127_2104057_1	706587.Desti_3612	4.1e-11	67.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria	1224|Proteobacteria	M	Pfam Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
MMS2_k127_21086_0	370438.PTH_1811	3.22e-148	481.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,260IR@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS2_k127_212513_2	1410638.JHXJ01000003_gene1541	1.359e-05	48.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,24819@186801|Clostridia,3WGNT@541000|Ruminococcaceae	186801|Clostridia	EF	Belongs to the CarB family	carB2	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS2_k127_212513_1	997884.HMPREF1068_02566	4.885e-17	85.0	COG4828@1|root,COG4828@2|Bacteria,4NTSB@976|Bacteroidetes,2FT4V@200643|Bacteroidia,4ARD2@815|Bacteroidaceae	976|Bacteroidetes	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
MMS2_k127_212513_0	1047013.AQSP01000133_gene2146	7.027e-50	186.0	COG0579@1|root,COG0579@2|Bacteria,2NPCR@2323|unclassified Bacteria	2|Bacteria	C	FAD dependent oxidoreductase	lhgO	-	1.1.99.2,1.4.3.3	ko:K00109,ko:K00273,ko:K15736	ko00260,ko00311,ko00330,ko00472,ko00650,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map00650,map01100,map01130,map04146	-	R00366,R02457,R02894,R02923,R03534,R04221,R07400	RC00006,RC00018,RC00031,RC00135	ko00000,ko00001,ko01000	-	-	-	DAO
MMS2_k127_2127297_0	555079.Toce_1156	8.327e-69	245.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,42FFX@68295|Thermoanaerobacterales	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
MMS2_k127_2127297_2	1123371.ATXH01000018_gene1389	1.849e-29	126.0	COG1586@1|root,COG1586@2|Bacteria,2GGST@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	-	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
MMS2_k127_2127297_1	1379698.RBG1_1C00001G0708	3.742e-65	231.0	COG0010@1|root,COG0010@2|Bacteria,2NPGU@2323|unclassified Bacteria	2|Bacteria	E	Arginase family	speB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS2_k127_2127297_3	1128398.Curi_c01840	2.86e-23	101.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,2692W@186813|unclassified Clostridiales	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
MMS2_k127_2152704_0	857293.CAAU_2656	2.1e-47	178.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,36DCM@31979|Clostridiaceae	186801|Clostridia	P	Na Pi-cotransporter II-like protein	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
MMS2_k127_2152704_1	1191523.MROS_2401	4.95e-08	62.0	29A93@1|root,32UVK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
MMS2_k127_216718_0	1499967.BAYZ01000118_gene3247	1.424e-77	265.0	COG1189@1|root,COG1189@2|Bacteria,2NPHR@2323|unclassified Bacteria	2|Bacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
MMS2_k127_216718_1	518766.Rmar_1517	1.645e-08	66.0	COG0457@1|root,COG1729@1|root,COG4105@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,1FJ24@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
MMS2_k127_2175721_0	477974.Daud_1050	1.241e-316	990.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
MMS2_k127_2175721_1	1459636.NTE_03059	2.196e-13	71.0	arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2202127_0	941639.BCO26_0001	1.923e-96	322.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,1ZBKI@1386|Bacillus	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
MMS2_k127_22045_1	867903.ThesuDRAFT_02308	2.809e-38	145.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3WCG8@538999|Clostridiales incertae sedis	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
MMS2_k127_22045_0	635013.TherJR_0068	1.46e-127	424.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,2602Z@186807|Peptococcaceae	186801|Clostridia	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
MMS2_k127_22045_2	868864.Dester_1075	0.0001546	46.0	COG0718@1|root,COG0718@2|Bacteria,2G4CX@200783|Aquificae	200783|Aquificae	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
MMS2_k127_2209512_1	521460.Athe_1715	2.921e-35	138.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,42GCN@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS2_k127_2209512_0	1120985.AUMI01000015_gene1637	1.402e-111	366.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4H20W@909932|Negativicutes	909932|Negativicutes	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_2215620_0	933115.GPDM_10305	4.161e-26	125.0	COG2911@1|root,COG4632@1|root,COG2911@2|Bacteria,COG4632@2|Bacteria	2|Bacteria	S	protein secretion	tagL	-	3.1.3.1,3.1.3.5,3.1.3.6,3.1.4.16	ko:K01077,ko:K01119,ko:K02664,ko:K08693	ko00230,ko00240,ko00730,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00730,map00760,map00790,map01100,map01110,map02020	M00126	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02135,R02148,R02370,R02719,R03537,R03538,R03929,R04620,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko00002,ko00537,ko01000,ko02035,ko02044,ko04147	-	-	-	Cu_amine_oxidN1,NAGPA,SLH
MMS2_k127_2215620_1	1450525.JATV01000015_gene2215	2.335e-12	76.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1HYJD@117743|Flavobacteriia,2NS7F@237|Flavobacterium	976|Bacteroidetes	S	Peptidase C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
MMS2_k127_222735_2	1192034.CAP_0793	2.074e-21	107.0	COG0515@1|root,COG0515@2|Bacteria,1P64D@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
MMS2_k127_222735_0	1123376.AUIU01000015_gene484	1.732e-59	226.0	COG0297@1|root,COG0297@2|Bacteria,3J0DJ@40117|Nitrospirae	40117|Nitrospirae	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
MMS2_k127_222735_1	298386.PBPRA0601	2.069e-24	107.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1XTS8@135623|Vibrionales	135623|Vibrionales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
MMS2_k127_2243413_0	264732.Moth_0515	1.862e-55	200.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,42FUW@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_2243413_1	401526.TcarDRAFT_0094	0.0001518	52.0	COG0671@1|root,COG0671@2|Bacteria,1UK1W@1239|Firmicutes,4H9AG@909932|Negativicutes	909932|Negativicutes	I	Exopolysaccharide biosynthesis protein YbjH	-	-	-	-	-	-	-	-	-	-	-	-	YjbH
MMS2_k127_2248248_0	568816.Acin_1623	4.654e-97	325.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4H21S@909932|Negativicutes	909932|Negativicutes	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
MMS2_k127_2248248_1	697281.Mahau_1319	2.184e-59	208.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42FKR@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
MMS2_k127_2265902_1	439235.Dalk_2412	7.512e-52	192.0	COG0745@1|root,COG1387@1|root,COG0745@2|Bacteria,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2MJIA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
MMS2_k127_2265902_0	1121335.Clst_2377	2.408e-63	222.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3WGCJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
MMS2_k127_2267473_1	796945.HMPREF1145_0103	2.197e-12	68.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,2PRTU@265975|Oribacterium	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
MMS2_k127_2267473_0	484770.UFO1_2705	5.555e-87	302.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,4H2GA@909932|Negativicutes	909932|Negativicutes	J	tRNA methylthiotransferase YqeV	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
MMS2_k127_2284878_1	203119.Cthe_0208	1.189e-45	171.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WHIX@541000|Ruminococcaceae	186801|Clostridia	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
MMS2_k127_2284878_2	1121472.AQWN01000003_gene1551	2.29e-34	138.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,260JY@186807|Peptococcaceae	186801|Clostridia	CI	Acetyl-CoA carboxylase, biotin carboxyl carrier protein	pycB	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
MMS2_k127_2284878_0	1121105.ATXL01000008_gene934	2.519e-56	202.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,4H9YX@91061|Bacilli,4AZC0@81852|Enterococcaceae	91061|Bacilli	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
MMS2_k127_2284878_3	696369.KI912183_gene1279	3.683e-34	135.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,261ZE@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
MMS2_k127_2304217_0	509191.AEDB02000103_gene3782	3.841e-12	79.0	COG0823@1|root,COG1470@1|root,COG1716@1|root,COG2730@1|root,COG3391@1|root,COG0823@2|Bacteria,COG1470@2|Bacteria,COG1716@2|Bacteria,COG2730@2|Bacteria,COG3391@2|Bacteria,1VQQT@1239|Firmicutes,248VB@186801|Clostridia,3WP2S@541000|Ruminococcaceae	186801|Clostridia	G	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	CBM_3,FlgD_ig,HYR
MMS2_k127_2309502_0	1341151.ASZU01000006_gene2816	4.886e-144	469.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,27B92@186824|Thermoactinomycetaceae	91061|Bacilli	L	breast cancer carboxy-terminal domain	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
MMS2_k127_2321610_0	340177.Cag_0335	5.354e-06	55.0	COG1538@1|root,COG1538@2|Bacteria,1FDME@1090|Chlorobi	1090|Chlorobi	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS2_k127_2327711_1	760568.Desku_3001	3.136e-123	403.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,260QV@186807|Peptococcaceae	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
MMS2_k127_2327711_2	246194.CHY_1101	1.19e-27	114.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,42GW8@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
MMS2_k127_2327711_0	635013.TherJR_0871	1.057e-194	616.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
MMS2_k127_2328273_0	748449.Halha_1870	6.35e-113	378.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WAEK@53433|Halanaerobiales	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
MMS2_k127_2328273_1	1089553.Tph_c05830	6.419e-105	350.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,42ES6@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
MMS2_k127_2328273_2	649761.HMPREF0973_01745	1.773e-38	145.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,4NEHE@976|Bacteroidetes,2FM8K@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS2_k127_2331279_0	323850.Shew_2535	5.154e-63	230.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,2Q8I7@267890|Shewanellaceae	1236|Gammaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	gadB	GO:0003674,GO:0003824,GO:0004068,GO:0016829,GO:0016830,GO:0016831	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
MMS2_k127_2343655_1	1321778.HMPREF1982_01813	0.0001073	46.0	COG5663@1|root,COG5663@2|Bacteria,1V2IT@1239|Firmicutes,24MK8@186801|Clostridia,26BQY@186813|unclassified Clostridiales	186801|Clostridia	S	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	-	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
MMS2_k127_2343655_0	574087.Acear_1156	7.685e-236	751.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3WA7U@53433|Halanaerobiales	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMS2_k127_2373328_0	526227.Mesil_0867	3.762e-31	136.0	COG0763@1|root,COG0763@2|Bacteria,1WMDU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	-
MMS2_k127_2373328_1	1123023.JIAI01000013_gene3997	4.511e-11	64.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4DYEK@85010|Pseudonocardiales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_2383088_0	1168059.KB899087_gene3446	7.512e-141	470.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3EYEP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	macB	-	-	ko:K05685	ko02010,map02010	M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
MMS2_k127_2383088_1	194439.CT0377	3.394e-71	252.0	COG0845@1|root,COG0845@2|Bacteria,1FDM9@1090|Chlorobi	1090|Chlorobi	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
MMS2_k127_2383088_2	96561.Dole_1629	2.459e-21	102.0	COG1538@1|root,COG1538@2|Bacteria,1Q54S@1224|Proteobacteria,42W8E@68525|delta/epsilon subdivisions,2WSDF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	FusA NodT family protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS2_k127_2391982_1	639282.DEFDS_0413	5.488e-62	220.0	COG1377@1|root,COG1377@2|Bacteria,2GESV@200930|Deferribacteres	200930|Deferribacteres	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
MMS2_k127_2391982_0	335541.Swol_0869	7.265e-127	420.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,42JMN@68298|Syntrophomonadaceae	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
MMS2_k127_2414525_1	880073.Calab_2216	1.049e-10	75.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	ebh	-	-	-	-	-	-	-	-	-	-	-	DUF1611,Inhibitor_I9,Peptidase_S8,SLH
MMS2_k127_2414525_0	1469607.KK073769_gene5630	3.598e-15	78.0	COG2852@1|root,COG2852@2|Bacteria,1G6T3@1117|Cyanobacteria,1HP2A@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
MMS2_k127_2416549_0	203124.Tery_1674	7.447e-21	105.0	2DBHM@1|root,2Z9AY@2|Bacteria,1G396@1117|Cyanobacteria,1H9MI@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2416549_1	768670.Calni_1175	6.496e-18	89.0	COG1216@1|root,COG1216@2|Bacteria,2GGKG@200930|Deferribacteres	200930|Deferribacteres	S	Glycosyltransferase like family	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
MMS2_k127_2421346_1	1396418.BATQ01000117_gene4581	5.682e-06	48.0	COG1089@1|root,COG1089@2|Bacteria,46SH0@74201|Verrucomicrobia,2ITUC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	-	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
MMS2_k127_2421346_0	717606.PaecuDRAFT_4483	8.776e-70	248.0	COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae	91061|Bacilli	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
MMS2_k127_2423407_0	580331.Thit_0811	6.343e-90	309.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,42FDS@68295|Thermoanaerobacterales	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
MMS2_k127_2423407_1	429009.Adeg_0579	5.425e-33	129.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,42EMG@68295|Thermoanaerobacterales	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
MMS2_k127_2432236_0	477974.Daud_2181	2.271e-96	326.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,26064@186807|Peptococcaceae	186801|Clostridia	J	TIGRFAM Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
MMS2_k127_2434394_0	247490.KSU1_D0757	1.114e-71	257.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	kpsD	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Caps_synth_GfcC,Poly_export,SLBB
MMS2_k127_2437976_2	373903.Hore_00450	7.383e-84	281.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3WABU@53433|Halanaerobiales	186801|Clostridia	P	ABC transporter	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
MMS2_k127_2437976_3	1131462.DCF50_p613	8.621e-62	216.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,261H1@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMS2_k127_2437976_1	1449126.JQKL01000009_gene349	1.063e-165	529.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,26AE5@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
MMS2_k127_2437976_4	574087.Acear_1430	1.474e-55	201.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,3WAR1@53433|Halanaerobiales	186801|Clostridia	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
MMS2_k127_2437976_5	867903.ThesuDRAFT_00073	6.79e-25	108.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,3WDJZ@538999|Clostridiales incertae sedis	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
MMS2_k127_2437976_0	1444309.JAQG01000099_gene4971	9.273e-199	627.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,4HARK@91061|Bacilli,26SJC@186822|Paenibacillaceae	91061|Bacilli	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
MMS2_k127_2437976_6	632518.Calow_0534	1.564e-17	84.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,24ACU@186801|Clostridia,42F5H@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
MMS2_k127_24577_1	1163409.UUA_10051	2.317e-09	66.0	2DIWG@1|root,3049N@2|Bacteria,1R88E@1224|Proteobacteria,1T49R@1236|Gammaproteobacteria,1X4QT@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
MMS2_k127_24577_0	316067.Geob_1997	4.909e-89	302.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS2_k127_2463447_0	935948.KE386494_gene471	7.403e-125	410.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_246403_0	1033734.CAET01000080_gene3305	4.5e-103	342.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,1ZB8H@1386|Bacillus	91061|Bacilli	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
MMS2_k127_246403_1	933262.AXAM01000014_gene270	7.457e-53	194.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2MJIB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
MMS2_k127_2501710_0	944480.ATUV01000001_gene1479	1.956e-63	222.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2M6QZ@213113|Desulfurellales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS2_k127_2506010_0	1449126.JQKL01000014_gene2976	8.12e-117	385.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,267KV@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
MMS2_k127_2506010_1	910314.HMPREF9220_0126	7.803e-84	284.0	COG1137@1|root,COG1137@2|Bacteria,1UJSV@1239|Firmicutes,4H1UQ@909932|Negativicutes	909932|Negativicutes	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
MMS2_k127_2506010_2	321327.CYA_1211	2.129e-79	277.0	COG0795@1|root,COG0795@2|Bacteria,1G14H@1117|Cyanobacteria,1GZDN@1129|Synechococcus	1117|Cyanobacteria	S	Permease, YjgP YjgQ family	ycf84	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
MMS2_k127_2506010_4	679201.HMPREF9334_01704	8.493e-35	145.0	COG4372@1|root,COG4372@2|Bacteria,1TRKA@1239|Firmicutes,4H36C@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF3084)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3084
MMS2_k127_2506010_5	1304874.JAFY01000005_gene1521	2.284e-10	66.0	COG0816@1|root,COG0816@2|Bacteria,3TBJM@508458|Synergistetes	508458|Synergistetes	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2506010_3	269799.Gmet_2367	3.896e-71	257.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,43TVN@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
MMS2_k127_2533620_1	318464.IO99_13085	4.324e-51	191.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,36DM6@31979|Clostridiaceae	186801|Clostridia	P	Transporter, CPA2 family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS2_k127_2533620_3	296591.Bpro_3508	5.641e-13	76.0	COG3290@1|root,COG3290@2|Bacteria,1QXG8@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HD_5,MASE3,PAS,PAS_9
MMS2_k127_2533620_0	444158.MmarC6_1371	3.327e-51	197.0	COG0840@1|root,arCOG02320@2157|Archaea,2Y7QV@28890|Euryarchaeota,23RVM@183939|Methanococci	183939|Methanococci	T	Integral membrane sensor signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,sCache_3_3
MMS2_k127_2533620_2	309799.DICTH_1250	1.062e-45	173.0	COG0115@1|root,COG0115@2|Bacteria	2|Bacteria	E	branched-chain-amino-acid transaminase activity	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS2_k127_2545898_0	273068.TTE2272	1.44e-98	332.0	COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,42ESN@68295|Thermoanaerobacterales	186801|Clostridia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
MMS2_k127_2545898_1	1131269.AQVV01000040_gene1632	2.357e-36	141.0	COG0200@1|root,COG0200@2|Bacteria	2|Bacteria	J	rRNA binding	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMS2_k127_2550957_0	747365.Thena_1423	1.459e-95	323.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,42GEZ@68295|Thermoanaerobacterales	186801|Clostridia	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_2557695_0	572479.Hprae_1950	5.333e-27	116.0	COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,24F0X@186801|Clostridia,3WAA6@53433|Halanaerobiales	186801|Clostridia	M	PFAM Surface antigen variable number repeat	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
MMS2_k127_2580095_0	37659.JNLN01000001_gene634	2.172e-26	111.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,36KFX@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
MMS2_k127_2580095_2	1121440.AUMA01000003_gene2984	3.579e-24	104.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2MDG6@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
MMS2_k127_2587170_1	1191523.MROS_2298	4.461e-24	105.0	COG1694@1|root,COG3956@2|Bacteria	2|Bacteria	E	TIGRFAM MazG family protein	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66,3.6.1.9	ko:K02428,ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R01855,R02100,R02720,R03004,R03036,R03531,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	iJN678.sll1005	MazG
MMS2_k127_2587170_0	1449126.JQKL01000009_gene318	2.715e-194	619.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,267QU@186813|unclassified Clostridiales	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
MMS2_k127_2597719_2	484770.UFO1_1095	1.892e-86	296.0	COG2605@1|root,COG2605@2|Bacteria,1UKBI@1239|Firmicutes,4H96R@909932|Negativicutes	909932|Negativicutes	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_2597719_6	1322246.BN4_12079	4.393e-43	168.0	COG0451@1|root,COG0451@2|Bacteria,1RBIE@1224|Proteobacteria,42QDU@68525|delta/epsilon subdivisions,2WJD4@28221|Deltaproteobacteria,2MBA7@213115|Desulfovibrionales	28221|Deltaproteobacteria	GM	NAD-dependent epimerase dehydratase	-	-	1.1.1.339	ko:K19180	ko00523,ko01130,map00523,map01130	-	R10190	RC00182	ko00000,ko00001,ko01000	-	-	-	Epimerase
MMS2_k127_2597719_4	1185652.USDA257_c10750	1.192e-55	199.0	COG1898@1|root,COG1898@2|Bacteria,1RDAB@1224|Proteobacteria,2U99D@28211|Alphaproteobacteria,4BMP4@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008830,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
MMS2_k127_2597719_1	1322246.BN4_12076	4.029e-126	413.0	COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,42QBV@68525|delta/epsilon subdivisions,2WQ8F@28221|Deltaproteobacteria,2MB41@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_2597719_0	1322246.BN4_12075	5.338e-142	462.0	COG0241@1|root,COG1208@1|root,COG0241@2|Bacteria,COG1208@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,2MBDI@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	hydrolase, HAD-superfamily, subfamily IIIA	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like,NTP_transferase
MMS2_k127_2597719_5	1499967.BAYZ01000063_gene6022	9.526e-55	208.0	COG1216@1|root,COG2148@1|root,COG1216@2|Bacteria,COG2148@2|Bacteria,2NP9Z@2323|unclassified Bacteria	2|Bacteria	GM	Glycosyltransferase like family 2	-	-	-	ko:K03606,ko:K07011	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3,Glyco_tranf_2_3,Glycos_transf_2
MMS2_k127_2597719_3	1128421.JAGA01000002_gene1117	3.638e-68	246.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2NPYM@2323|unclassified Bacteria	2|Bacteria	L	Glycosyltransferase like family 2	gumK	-	2.4.1.264	ko:K07011,ko:K13659	-	-	R09732	RC00005,RC00049	ko00000,ko01000,ko01003	-	GT70	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_1,Glycos_transf_2
MMS2_k127_2610530_3	593750.Metfor_0597	2.366e-06	53.0	arCOG11068@1|root,arCOG11068@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2610530_1	639030.JHVA01000001_gene1177	3.855e-09	59.0	COG2217@1|root,COG2217@2|Bacteria,3Y39H@57723|Acidobacteria,2JHMU@204432|Acidobacteriia	204432|Acidobacteriia	P	heavy metal translocating P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
MMS2_k127_2610530_2	1501230.ET33_01130	6.749e-07	59.0	COG4658@1|root,COG4658@2|Bacteria,1V4CY@1239|Firmicutes,4HHSS@91061|Bacilli,26V69@186822|Paenibacillaceae	91061|Bacilli	C	NQR2, RnfD, RnfE family	-	-	-	-	-	-	-	-	-	-	-	-	NQR2_RnfD_RnfE
MMS2_k127_2610530_0	572544.Ilyop_0968	9.619e-20	95.0	COG1622@1|root,COG1622@2|Bacteria,37CJY@32066|Fusobacteria	2|Bacteria	C	cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
MMS2_k127_2617869_2	1121930.AQXG01000001_gene1462	7.414e-26	107.0	COG1209@1|root,COG1209@2|Bacteria	2|Bacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS2_k127_2617869_0	1121360.AUAQ01000017_gene2495	1.491e-89	301.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,22K6P@1653|Corynebacteriaceae	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
MMS2_k127_2617869_3	555079.Toce_1042	5.624e-09	64.0	COG1193@1|root,COG1193@2|Bacteria,1UHZ5@1239|Firmicutes,25E7T@186801|Clostridia,42GTB@68295|Thermoanaerobacterales	186801|Clostridia	L	negative regulation of DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2617869_1	1304880.JAGB01000001_gene668	2.379e-56	200.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
MMS2_k127_2631216_0	1321778.HMPREF1982_02293	1.165e-158	509.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,267QX@186813|unclassified Clostridiales	186801|Clostridia	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMS2_k127_2631216_1	428125.CLOLEP_00040	2.31e-18	85.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,3WIA5@541000|Ruminococcaceae	186801|Clostridia	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
MMS2_k127_2632491_3	717785.HYPMC_1293	1.676e-39	153.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,3N6K6@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
MMS2_k127_2632491_1	1047013.AQSP01000123_gene1538	1.618e-58	205.0	COG2033@1|root,COG2033@2|Bacteria,2NPTG@2323|unclassified Bacteria	2|Bacteria	C	Desulfoferrodoxin, N-terminal domain	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
MMS2_k127_2632491_4	338963.Pcar_2796	2.319e-22	97.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,42VC4@68525|delta/epsilon subdivisions,2WRDM@28221|Deltaproteobacteria,43VQP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Rubredoxin	rub	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Rubredoxin
MMS2_k127_2632491_0	1047013.AQSP01000144_gene920	2.343e-162	519.0	COG0426@1|root,COG0426@2|Bacteria,2NPHV@2323|unclassified Bacteria	2|Bacteria	C	Metallo-beta-lactamase superfamily	dfa1	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Flavodoxin_1,Lactamase_B
MMS2_k127_2632491_2	706587.Desti_1245	6.492e-46	169.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MRP3@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ferritin-like domain	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
MMS2_k127_2633798_2	102129.Lepto7375DRAFT_1163	2.494e-23	102.0	COG0438@1|root,COG0438@2|Bacteria,1G0Z5@1117|Cyanobacteria,1H7YK@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_2633798_0	269799.Gmet_0057	2.887e-156	505.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,43TS3@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMS2_k127_2633798_1	251229.Chro_4492	1.941e-61	215.0	COG1045@1|root,COG1045@2|Bacteria,1G0WM@1117|Cyanobacteria,3VIXT@52604|Pleurocapsales	1117|Cyanobacteria	E	Bacterial transferase hexapeptide (three repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
MMS2_k127_2640148_1	880072.Desac_0368	1.768e-20	93.0	COG1216@1|root,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,42Q1D@68525|delta/epsilon subdivisions,2WJYJ@28221|Deltaproteobacteria,2MQV7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_2640148_0	324057.Pjdr2_6111	1.489e-44	176.0	COG2730@1|root,COG2730@2|Bacteria,1VIZE@1239|Firmicutes,4HTXS@91061|Bacilli,26WJV@186822|Paenibacillaceae	91061|Bacilli	G	Cellulase (glycosyl hydrolase family 5)	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
MMS2_k127_2640148_2	938288.HG326226_gene745	1.724e-16	83.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,2682E@186813|unclassified Clostridiales	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS2_k127_264133_0	443143.GM18_0753	7.152e-71	248.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
MMS2_k127_264133_1	373903.Hore_11550	2.177e-07	61.0	COG0457@1|root,COG0457@2|Bacteria,1UJSQ@1239|Firmicutes,25F94@186801|Clostridia,3WCAW@53433|Halanaerobiales	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2655723_1	1123288.SOV_3c03800	1.721e-56	201.0	COG1044@1|root,COG1044@2|Bacteria,1TP7W@1239|Firmicutes,4H1ZV@909932|Negativicutes	909932|Negativicutes	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
MMS2_k127_2655723_0	555088.DealDRAFT_2723	5.431e-78	273.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,42JHF@68298|Syntrophomonadaceae	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_2657594_0	243231.GSU2028	1.561e-39	163.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,43UJ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II and III secretion system protein	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
MMS2_k127_2657594_1	717231.Flexsi_0214	5.149e-10	61.0	COG0240@1|root,COG0240@2|Bacteria,2GENT@200930|Deferribacteres	200930|Deferribacteres	I	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
MMS2_k127_268463_0	747365.Thena_0155	5.748e-74	260.0	COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,42F9I@68295|Thermoanaerobacterales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS2_k127_2687371_1	555079.Toce_0967	9.298e-27	113.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS2_k127_2687371_0	439481.Aboo_1543	2.139e-63	222.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,3F36H@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
MMS2_k127_2695588_0	335541.Swol_0376	5.109e-187	592.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42KEK@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
MMS2_k127_2695588_1	555779.Dthio_PD3337	3.987e-08	63.0	COG0707@1|root,COG1443@1|root,COG0707@2|Bacteria,COG1443@2|Bacteria,1P8AM@1224|Proteobacteria,42T9Z@68525|delta/epsilon subdivisions,2WP8K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS2_k127_272493_1	477974.Daud_0675	5.19e-50	203.0	COG2203@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,25F8J@186801|Clostridia,2673W@186807|Peptococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9
MMS2_k127_272493_0	290315.Clim_0309	2.742e-74	257.0	COG1207@1|root,COG1207@2|Bacteria,1FDEZ@1090|Chlorobi	1090|Chlorobi	M	Nucleotidyl transferase	-	-	2.7.7.23	ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_3,NTP_transferase
MMS2_k127_272493_2	273068.TTE0919	6.677e-07	52.0	COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia,42GMQ@68295|Thermoanaerobacterales	186801|Clostridia	H	SMART Metal-dependent phosphohydrolase, HD region	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,HD
MMS2_k127_2753017_0	644282.Deba_1140	5.067e-171	561.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS2_k127_2759870_1	498761.HM1_2103	5.054e-21	97.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
MMS2_k127_2759870_0	515635.Dtur_0951	1.39e-55	204.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
MMS2_k127_2778174_0	1303518.CCALI_01654	2.154e-211	665.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria	2|Bacteria	E	L-glutamate biosynthetic process	gltB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
MMS2_k127_2783509_1	1173024.KI912148_gene3584	3.105e-47	178.0	COG1216@1|root,COG1216@2|Bacteria,1G0X3@1117|Cyanobacteria,1JJG1@1189|Stigonemataceae	1117|Cyanobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064,Glycos_transf_2
MMS2_k127_2783509_0	100226.SCO3463	1.448e-63	226.0	COG0005@1|root,COG0005@2|Bacteria,2GKGG@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS2_k127_2783509_2	593750.Metfor_0382	1.259e-18	85.0	COG1592@1|root,arCOG01097@2157|Archaea,2XWSA@28890|Euryarchaeota,2NBII@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Rubrerythrin	rbr-1	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS2_k127_278427_0	1232453.BAIF02000055_gene1220	4.275e-91	310.0	COG1063@1|root,COG1063@2|Bacteria,1U9ZD@1239|Firmicutes,24EJR@186801|Clostridia	186801|Clostridia	E	COG1063 Threonine dehydrogenase and related Zn-dependent	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS2_k127_278427_1	697281.Mahau_1767	1.249e-55	203.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,42EWH@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Ribulose-phosphate 3-epimerase	rpe	-	5.1.3.1	ko:K01783,ko:K17195	ko00030,ko00040,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529,R09031	RC00540,RC03111	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMS2_k127_278427_2	545695.TREAZ_2890	6.993e-29	118.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	eryC	-	5.1.3.38	ko:K21909	-	-	-	-	ko00000,ko01000	-	-	-	AP_endonuc_2
MMS2_k127_2805840_0	1379698.RBG1_1C00001G0961	2.973e-136	445.0	COG0550@1|root,COG0550@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS2_k127_2805840_1	1382304.JNIL01000001_gene811	1.293e-84	290.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,2784W@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
MMS2_k127_2812712_1	909663.KI867150_gene2901	2.493e-45	171.0	COG4185@1|root,COG4185@2|Bacteria,1RFDC@1224|Proteobacteria,42TT0@68525|delta/epsilon subdivisions,2WQEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zeta_toxin
MMS2_k127_2812712_0	386456.JQKN01000017_gene870	7.908e-57	205.0	arCOG01788@1|root,arCOG01788@2157|Archaea,2Y7W7@28890|Euryarchaeota,23PMY@183925|Methanobacteria	183925|Methanobacteria	Q	PFAM Methyltransferase	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25
MMS2_k127_2814824_0	667014.Thein_1717	2.22e-112	371.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
MMS2_k127_2814824_1	1168065.DOK_03798	6.221e-21	106.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J4XS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_2673	ACT_4,HD_4,RelA_SpoT,TGS
MMS2_k127_284042_1	237368.SCABRO_01644	1.15e-71	253.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	B12-binding,Glycos_transf_2,Radical_SAM
MMS2_k127_284042_0	449447.MAE_59470	1.835e-88	305.0	COG0463@1|root,COG0463@2|Bacteria,1G4BG@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_284828_0	46234.ANA_C20480	1.055e-78	271.0	COG1109@1|root,COG1109@2|Bacteria,1G3BW@1117|Cyanobacteria,1HJ9A@1161|Nostocales	1117|Cyanobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS2_k127_284828_2	1248232.BANQ01000131_gene1103	4.021e-05	52.0	COG2165@1|root,COG2165@2|Bacteria,1N5DT@1224|Proteobacteria,1SV2Z@1236|Gammaproteobacteria,1XYS5@135623|Vibrionales	135623|Vibrionales	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K10924	ko05111,map05111	-	-	-	ko00000,ko00001,ko02044	-	-	-	N_methyl
MMS2_k127_284828_1	377629.TERTU_1146	9.705e-06	49.0	2ATYA@1|root,31JHY@2|Bacteria,1QAXH@1224|Proteobacteria,1T6D5@1236|Gammaproteobacteria,2PQK4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2850561_3	562970.Btus_1421	3.323e-45	169.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,4HHMA@91061|Bacilli,278ES@186823|Alicyclobacillaceae	91061|Bacilli	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008463,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
MMS2_k127_2850561_1	580331.Thit_1312	1.78e-90	307.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,42FC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
MMS2_k127_2850561_2	643648.Slip_0811	2.301e-47	174.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,42K0R@68298|Syntrophomonadaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
MMS2_k127_2850561_0	1125863.JAFN01000001_gene1365	2.346e-300	931.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	NRDD
MMS2_k127_2853670_0	373903.Hore_09880	7.655e-93	317.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WACI@53433|Halanaerobiales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
MMS2_k127_2858945_2	309801.trd_1313	2.877e-29	129.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2G67H@200795|Chloroflexi,27XI6@189775|Thermomicrobia	189775|Thermomicrobia	T	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
MMS2_k127_2858945_4	1121861.KB899929_gene267	1.754e-06	58.0	COG2815@1|root,COG2815@2|Bacteria,1Q8QJ@1224|Proteobacteria,2UXNT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PASTA	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
MMS2_k127_2858945_1	586413.CCDL010000002_gene2517	1.378e-77	265.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,23J53@182709|Oceanobacillus	91061|Bacilli	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMS2_k127_2858945_0	1121468.AUBR01000026_gene2918	5.551e-113	375.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
MMS2_k127_2858945_3	1267211.KI669560_gene2288	3.658e-16	85.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1IPCA@117747|Sphingobacteriia	976|Bacteroidetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS2_k127_2858945_5	504487.JCM19302_1728	0.0003259	51.0	COG3746@1|root,COG3746@2|Bacteria,4NIID@976|Bacteroidetes,1I11K@117743|Flavobacteriia	976|Bacteroidetes	P	Phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4,Porin_O_P
MMS2_k127_2874837_0	309800.C498_18488	1.218e-24	108.0	COG0475@1|root,arCOG01955@2157|Archaea,2XT4U@28890|Euryarchaeota,23SD1@183963|Halobacteria	183963|Halobacteria	P	COG0475 Kef-type K transport systems, membrane components	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
MMS2_k127_2886552_1	1165096.ARWF01000001_gene1971	1.133e-21	101.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VHM2@28216|Betaproteobacteria	28216|Betaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
MMS2_k127_2886552_0	1197130.BAFM01000010_gene1855	1.199e-23	109.0	COG1208@1|root,arCOG00664@2157|Archaea,2XTG9@28890|Euryarchaeota,23T96@183963|Halobacteria	183963|Halobacteria	M	COG1209 dTDP-glucose pyrophosphorylase	aglF	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS2_k127_2886552_2	796606.BMMGA3_15505	0.0004509	46.0	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,4HK40@91061|Bacilli,1ZN6H@1386|Bacillus	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS2_k127_289727_2	406124.ACPC01000018_gene2611	1.27e-26	117.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,4HABG@91061|Bacilli,1ZBG2@1386|Bacillus	91061|Bacilli	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS2_k127_289727_0	237368.SCABRO_02637	2.384e-110	364.0	COG1180@1|root,COG1180@2|Bacteria,2IYWA@203682|Planctomycetes	203682|Planctomycetes	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
MMS2_k127_289727_1	340099.Teth39_2062	5.763e-102	343.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,42ESC@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
MMS2_k127_2897672_0	555079.Toce_0698	1.018e-147	479.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,42FFC@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,RnfC_N,SLBB
MMS2_k127_2897672_1	1123059.KB823011_gene1615	1.14e-08	57.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,2UASW@28211|Alphaproteobacteria,440WS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Aspartate decarboxylase	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
MMS2_k127_2912335_0	1313265.JNIE01000004_gene479	3.078e-81	273.0	COG0481@1|root,COG0481@2|Bacteria,2G3R9@200783|Aquificae	200783|Aquificae	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
MMS2_k127_2912335_1	1379698.RBG1_1C00001G1818	1.63e-06	60.0	COG2067@1|root,COG2067@2|Bacteria,2NR34@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2912335_2	533240.CRC_02718	3.553e-05	56.0	COG1649@1|root,COG1649@2|Bacteria,1G34D@1117|Cyanobacteria,1HKR0@1161|Nostocales	1117|Cyanobacteria	S	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	GHL10,SLH
MMS2_k127_2918428_1	697284.ERIC2_c21360	4.762e-49	176.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,4H9N5@91061|Bacilli,26QUT@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS2_k127_2918428_0	1209989.TepiRe1_1597	3.76e-60	215.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,42G1Y@68295|Thermoanaerobacterales	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
MMS2_k127_2918428_4	1121423.JONT01000001_gene2088	7.768e-19	91.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,261ZS@186807|Peptococcaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
MMS2_k127_2918428_3	378806.STAUR_4960	3.298e-25	109.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2YTWD@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
MMS2_k127_2918428_2	1123242.JH636436_gene439	3.724e-26	111.0	COG0345@1|root,COG0345@2|Bacteria,2IY5U@203682|Planctomycetes	203682|Planctomycetes	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
MMS2_k127_2920275_2	696281.Desru_2032	6.988e-16	90.0	COG4191@1|root,COG4191@2|Bacteria,1UJKE@1239|Firmicutes,25F5A@186801|Clostridia,266S2@186807|Peptococcaceae	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMS2_k127_2920275_0	1499967.BAYZ01000068_gene1949	3.779e-26	123.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
MMS2_k127_2920275_1	1047013.AQSP01000130_gene1879	8.308e-18	87.0	COG2426@1|root,COG2426@2|Bacteria,2NRIQ@2323|unclassified Bacteria	2|Bacteria	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
MMS2_k127_295635_0	439235.Dalk_3481	0.0	1076.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS2_k127_2982745_0	574087.Acear_1673	9.076e-58	213.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,3WAB0@53433|Halanaerobiales	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS2_k127_2982745_1	247490.KSU1_C0449	4.314e-52	195.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,DUF4347,Peptidase_S8
MMS2_k127_2988811_0	330214.NIDE0964	1.044e-22	109.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0964|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2991998_0	289377.HL41_03640	1.119e-46	178.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GH4Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107,4.2.1.75	ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
MMS2_k127_2991998_1	498848.TaqDRAFT_4048	9.863e-33	131.0	COG0181@1|root,COG0181@2|Bacteria,1WIDD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
MMS2_k127_3011346_0	304371.MCP_2700	9.359e-135	434.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,2N9B4@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS2_k127_3033282_4	1069080.KB913028_gene886	2.008e-10	64.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,4H21Q@909932|Negativicutes	909932|Negativicutes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
MMS2_k127_3033282_2	1499967.BAYZ01000102_gene3573	1.286e-54	211.0	COG3979@1|root,COG3979@2|Bacteria	2|Bacteria	S	chitin catabolic process	chiA	GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005623,GO:0008843,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.2.1.14,3.2.1.17	ko:K01183,ko:K03933,ko:K13381	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	AA10,CBM15,CBM73,GH18	-	CBM_5_12,DUF5011,LPMO_10,Peptidase_M60
MMS2_k127_3033282_1	1444309.JAQG01000029_gene2473	1.591e-89	302.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,4HAV5@91061|Bacilli,26QHC@186822|Paenibacillaceae	91061|Bacilli	S	metallophosphoesterase	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
MMS2_k127_3033282_0	574087.Acear_1474	1.565e-174	561.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3WA6B@53433|Halanaerobiales	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
MMS2_k127_3033282_3	203119.Cthe_1050	3.471e-50	181.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3WGST@541000|Ruminococcaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
MMS2_k127_305358_1	237368.SCABRO_02056	6.023e-38	147.0	COG0298@1|root,COG0502@1|root,COG0298@2|Bacteria,COG0502@2|Bacteria	2|Bacteria	H	biotin synthase activity	hypC	-	2.8.1.6	ko:K01012,ko:K04653	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS11355	BATS,HupF_HypC,Radical_SAM
MMS2_k127_305358_0	1168034.FH5T_04505	7.055e-170	543.0	COG0502@1|root,COG0502@2|Bacteria,4NEI7@976|Bacteroidetes,2FM8N@200643|Bacteroidia	976|Bacteroidetes	C	In Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
MMS2_k127_305358_2	552811.Dehly_0917	1.959e-34	136.0	COG2081@1|root,COG2081@2|Bacteria,2GBTN@200795|Chloroflexi,34CND@301297|Dehalococcoidia	301297|Dehalococcoidia	S	FAD dependent oxidoreductase	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
MMS2_k127_3054997_1	1173029.JH980292_gene1765	3.652e-08	55.0	COG1215@1|root,COG1215@2|Bacteria,1GHF8@1117|Cyanobacteria,1H7FV@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_3054997_0	679926.Mpet_1374	9.681e-181	574.0	COG0399@1|root,arCOG00118@2157|Archaea,2XV66@28890|Euryarchaeota	28890|Euryarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
MMS2_k127_3061499_0	517418.Ctha_0042	2.352e-205	654.0	COG3968@1|root,COG3968@2|Bacteria,1FD6N@1090|Chlorobi	1090|Chlorobi	S	PFAM glutamine synthetase catalytic region	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
MMS2_k127_3062224_0	935948.KE386495_gene1643	1.762e-71	254.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
MMS2_k127_3062972_1	1121289.JHVL01000013_gene1610	3.815e-39	150.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
MMS2_k127_3062972_2	937774.TEQUI_0986	1.857e-26	113.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,3T48Y@506|Alcaligenaceae	28216|Betaproteobacteria	S	Acyl-CoA thioesterase	ybgC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS2_k127_3062972_0	289376.THEYE_A1767	1.447e-41	156.0	COG0128@1|root,COG0128@2|Bacteria,3J0BZ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS2_k127_3069427_1	237368.SCABRO_03336	6.622e-59	212.0	COG1180@1|root,COG1180@2|Bacteria,2J29S@203682|Planctomycetes	203682|Planctomycetes	O	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
MMS2_k127_3069427_0	401053.AciPR4_1793	6.957e-73	249.0	COG1945@1|root,COG1945@2|Bacteria,3Y3KR@57723|Acidobacteria,2JIBD@204432|Acidobacteriia	204432|Acidobacteriia	S	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	-	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
MMS2_k127_3069427_2	379066.GAU_3589	1.562e-31	128.0	COG0300@1|root,COG0300@2|Bacteria,1ZUD2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS2_k127_3114487_1	673860.AciM339_0815	2.533e-49	186.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota	28890|Euryarchaeota	S	Oxidoreductase domain protein	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS2_k127_3114487_0	867903.ThesuDRAFT_00243	1.329e-57	213.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3WCJ6@538999|Clostridiales incertae sedis	186801|Clostridia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
MMS2_k127_3124298_1	477974.Daud_0217	2.692e-72	258.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,260I2@186807|Peptococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS2_k127_3124298_2	96561.Dole_0704	1.206e-59	209.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,2MJVJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMS2_k127_3124298_3	760568.Desku_3061	1.444e-55	198.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,261BV@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMS2_k127_3124298_0	635013.TherJR_0293	5e-324	1000.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,2600F@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS2_k127_3141351_1	696281.Desru_1219	6.862e-63	222.0	COG1861@1|root,COG1861@2|Bacteria,1U4YD@1239|Firmicutes,24B0X@186801|Clostridia,264GQ@186807|Peptococcaceae	186801|Clostridia	M	Cytidylyltransferase	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
MMS2_k127_3141351_0	247490.KSU1_A0004	9.569e-140	452.0	COG4310@1|root,COG4310@2|Bacteria	2|Bacteria	Q	Domain of unknown function (DUF2172)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2172,DUF4910,HTH_47,Peptidase_M28
MMS2_k127_3144193_2	926561.KB900618_gene107	6.272e-30	123.0	COG1418@1|root,COG1418@2|Bacteria,1UVYG@1239|Firmicutes,25MMF@186801|Clostridia,3WC72@53433|Halanaerobiales	186801|Clostridia	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3144193_0	768670.Calni_0496	4.223e-225	708.0	COG0369@1|root,COG1151@2|Bacteria,2GEIW@200930|Deferribacteres	200930|Deferribacteres	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
MMS2_k127_3144193_1	331678.Cphamn1_0504	1.437e-76	262.0	COG1145@1|root,COG1145@2|Bacteria,1FEGQ@1090|Chlorobi	1090|Chlorobi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_3144193_4	706587.Desti_1283	1.412e-08	60.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria,2MR3G@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	NRDD
MMS2_k127_3144193_3	525903.Taci_1748	2.096e-16	83.0	COG1959@1|root,COG1959@2|Bacteria,3TBDP@508458|Synergistetes	508458|Synergistetes	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS2_k127_3147274_0	526222.Desal_1601	3.846e-90	302.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P5B@68525|delta/epsilon subdivisions,2WM02@28221|Deltaproteobacteria,2M7WB@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Purine nucleoside phosphorylase involved in purine salvage	mtap	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS2_k127_3148928_2	1293054.HSACCH_02406	1.782e-16	81.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,3WAAS@53433|Halanaerobiales	186801|Clostridia	M	NAD dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_3148928_0	744872.Spica_2717	1.525e-63	232.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.348	ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMS2_k127_3148928_1	1173028.ANKO01000160_gene5058	5.414e-27	117.0	COG0535@1|root,COG0535@2|Bacteria,1G2HH@1117|Cyanobacteria,1H9HN@1150|Oscillatoriales	1117|Cyanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS2_k127_3187691_3	1449126.JQKL01000021_gene82	5.269e-09	64.0	COG1589@1|root,COG1589@2|Bacteria,1VEMW@1239|Firmicutes,24QKM@186801|Clostridia,26CMS@186813|unclassified Clostridiales	186801|Clostridia	D	POTRA domain, FtsQ-type	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
MMS2_k127_3187691_0	1123288.SOV_1c10030	2.666e-85	292.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,4H1WX@909932|Negativicutes	909932|Negativicutes	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
MMS2_k127_3187691_2	1077974.GOEFS_132_00050	3.522e-21	107.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4GC7B@85026|Gordoniaceae	201174|Actinobacteria	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
MMS2_k127_3187691_1	575540.Isop_1077	2.367e-71	256.0	COG0205@1|root,COG0205@2|Bacteria,2IXXF@203682|Planctomycetes	203682|Planctomycetes	G	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
MMS2_k127_3190181_0	1173263.Syn7502_02756	1.507e-164	530.0	COG0034@1|root,COG0034@2|Bacteria,1G1C9@1117|Cyanobacteria,1GZD0@1129|Synechococcus	1117|Cyanobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMS2_k127_3190181_4	485913.Krac_6878	1.811e-13	72.0	2EQ8R@1|root,33HV0@2|Bacteria,2G91J@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3190181_2	1408254.T458_13325	7.735e-114	375.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,4HABW@91061|Bacilli,26S3Q@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_3190181_3	696281.Desru_1284	9.364e-70	241.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,261MS@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
MMS2_k127_3190181_1	1209989.TepiRe1_1179	1.135e-114	381.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,42EZN@68295|Thermoanaerobacterales	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
MMS2_k127_3222075_1	697281.Mahau_0277	3.498e-55	198.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,42GKU@68295|Thermoanaerobacterales	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
MMS2_k127_3222075_0	1121439.dsat_2824	7.152e-57	209.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2M8M2@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
MMS2_k127_3222075_2	938288.HG326224_gene1482	2.71e-27	117.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,268IJ@186813|unclassified Clostridiales	186801|Clostridia	V	VanW like protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
MMS2_k127_3245800_3	1121939.L861_03120	1.578e-27	115.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XJKA@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
MMS2_k127_3245800_4	1996.JOFO01000006_gene378	4.794e-12	68.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
MMS2_k127_3245800_2	1200792.AKYF01000019_gene4666	6.78e-45	168.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,4HFUS@91061|Bacilli,26R0K@186822|Paenibacillaceae	91061|Bacilli	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
MMS2_k127_3245800_0	580340.Tlie_0727	7.984e-233	733.0	COG0441@1|root,COG0441@2|Bacteria,3T9WZ@508458|Synergistetes	508458|Synergistetes	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
MMS2_k127_3245800_1	1121423.JONT01000004_gene1603	1.951e-103	345.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,260S5@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
MMS2_k127_32600_0	880073.Calab_3419	1.653e-144	464.0	COG1088@1|root,COG1088@2|Bacteria,2NNRC@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3464	GDP_Man_Dehyd
MMS2_k127_32600_1	309799.DICTH_0148	1.691e-70	242.0	COG1209@1|root,COG1209@2|Bacteria	2|Bacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS2_k127_3278694_0	697281.Mahau_0989	4.427e-20	105.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
MMS2_k127_329403_0	316274.Haur_0080	4.593e-66	235.0	COG0726@1|root,COG0726@2|Bacteria,2G8CG@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
MMS2_k127_329403_1	194439.CT0132	2.823e-26	110.0	COG0724@1|root,COG0724@2|Bacteria,1FE64@1090|Chlorobi	1090|Chlorobi	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
MMS2_k127_3299799_1	1227349.C170_26733	2.55e-34	137.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,4H9XK@91061|Bacilli,26SZ9@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU34910	Histidinol_dh
MMS2_k127_3299799_0	1172179.AUKV01000006_gene6356	5.588e-70	247.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria	201174|Actinobacteria	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
MMS2_k127_3301887_0	1379698.RBG1_1C00001G0198	3.114e-05	56.0	COG2885@1|root,COG5276@1|root,COG2885@2|Bacteria,COG5276@2|Bacteria,2NRZP@2323|unclassified Bacteria	2|Bacteria	M	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
MMS2_k127_3308629_1	373903.Hore_10870	1.023e-91	305.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3WAF9@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01703,ko:K20452	ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04465	Aconitase
MMS2_k127_3308629_2	1121468.AUBR01000010_gene2458	1.677e-68	236.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,42G3R@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMS2_k127_3308629_0	1121434.AULY01000007_gene1359	5.279e-134	434.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2M9GX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS2_k127_3319447_0	1232410.KI421426_gene1373	4.158e-120	394.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,43U78@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMS2_k127_3347891_0	645991.Sgly_3283	1.502e-190	602.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,2609R@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS2_k127_3347891_2	768710.DesyoDRAFT_5304	4.497e-86	290.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,25ZZ9@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM Cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
MMS2_k127_3347891_3	1069080.KB913028_gene631	7.991e-61	221.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,4H36P@909932|Negativicutes	909932|Negativicutes	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
MMS2_k127_3347891_4	666686.B1NLA3E_10560	2.079e-35	151.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,4IQKZ@91061|Bacilli,1ZRKZ@1386|Bacillus	91061|Bacilli	O	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3,SurA_N_3
MMS2_k127_3347891_1	521460.Athe_1752	3.674e-105	353.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,42FCM@68295|Thermoanaerobacterales	186801|Clostridia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS2_k127_3352416_0	861299.J421_1684	5.188e-21	104.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMS2_k127_3356032_0	720554.Clocl_1402	1.696e-63	236.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,3WGRB@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the FtsK SpoIIIE SftA family	spoIIIE	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
MMS2_k127_336025_3	1444309.JAQG01000045_gene3327	4.601e-17	81.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,4H9SY@91061|Bacilli,26RZP@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMS2_k127_336025_0	158190.SpiGrapes_0995	6.092e-43	165.0	COG0801@1|root,COG0801@2|Bacteria,2J8EN@203691|Spirochaetes	203691|Spirochaetes	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
MMS2_k127_336025_1	1304284.L21TH_1555	1.433e-39	151.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,36IUF@31979|Clostridiaceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
MMS2_k127_336025_2	1121423.JONT01000006_gene2410	2.625e-22	104.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,261MZ@186807|Peptococcaceae	186801|Clostridia	O	PFAM Peptidase M22, glycoprotease	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
MMS2_k127_3365506_3	436308.Nmar_0141	1.466e-07	53.0	COG0318@1|root,arCOG00856@2157|Archaea	2157|Archaea	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS2_k127_3365506_2	388739.RSK20926_01067	5.064e-08	62.0	COG0346@1|root,COG0346@2|Bacteria,1P8AK@1224|Proteobacteria,2UWTZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3365506_1	682795.AciX8_1488	2.44e-12	76.0	COG0500@1|root,COG2226@2|Bacteria,3Y8V7@57723|Acidobacteria	57723|Acidobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3365506_0	445971.ANASTE_00376	7.444e-42	160.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,25VAD@186806|Eubacteriaceae	186801|Clostridia	E	Psort location Cytoplasmic, score	aspC	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_33686_0	574087.Acear_2202	8.215e-22	111.0	COG2911@1|root,COG2911@2|Bacteria,1TQZZ@1239|Firmicutes,24GTE@186801|Clostridia,3WAJT@53433|Halanaerobiales	186801|Clostridia	S	PFAM Family of	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,TamB
MMS2_k127_3368867_6	401526.TcarDRAFT_1638	1.277e-19	97.0	COG0845@1|root,COG0845@2|Bacteria,1V01E@1239|Firmicutes,4H2QA@909932|Negativicutes	909932|Negativicutes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
MMS2_k127_3368867_0	1123288.SOV_6c01030	6.806e-93	316.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H1VG@909932|Negativicutes	909932|Negativicutes	V	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
MMS2_k127_3368867_1	1047013.AQSP01000139_gene2333	3.799e-91	313.0	COG0842@1|root,COG0842@2|Bacteria,2NPA6@2323|unclassified Bacteria	2|Bacteria	V	ABC-type multidrug transport system, permease component	ybhS	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
MMS2_k127_3368867_3	349521.HCH_00236	2.939e-66	233.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XHSS@135619|Oceanospirillales	135619|Oceanospirillales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_3368867_2	247490.KSU1_D0844	6.303e-80	273.0	COG1131@1|root,COG1131@2|Bacteria,2J23F@203682|Planctomycetes	203682|Planctomycetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
MMS2_k127_3368867_4	671143.DAMO_2133	2.098e-44	171.0	COG0845@1|root,COG0845@2|Bacteria,2NPNY@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	ybhG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
MMS2_k127_3368867_5	1009370.ALO_05930	2.044e-41	168.0	COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes	909932|Negativicutes	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
MMS2_k127_3375662_0	309801.trd_1269	1.438e-25	122.0	COG0616@1|root,COG0616@2|Bacteria,2G8IM@200795|Chloroflexi	200795|Chloroflexi	OU	signal peptide peptidase	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMS2_k127_3381374_0	32057.KB217478_gene3224	1.061e-35	144.0	2C6BU@1|root,32S87@2|Bacteria,1G8M3@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3390657_1	1121468.AUBR01000010_gene2467	3.801e-65	228.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,42F08@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
MMS2_k127_3390657_0	1286171.EAL2_c01070	6.342e-85	298.0	COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,248KF@186801|Clostridia,25Y17@186806|Eubacteriaceae	186801|Clostridia	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
MMS2_k127_3392510_0	484770.UFO1_0157	2.263e-31	138.0	COG1807@1|root,COG1807@2|Bacteria,1UY16@1239|Firmicutes,4H35V@909932|Negativicutes	909932|Negativicutes	M	dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS2_k127_3393371_2	748658.KB907312_gene1969	5.539e-07	52.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1WW0T@135613|Chromatiales	135613|Chromatiales	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
MMS2_k127_3393371_1	1379698.RBG1_1C00001G1219	6.21e-21	99.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
MMS2_k127_3393371_0	401526.TcarDRAFT_1548	3.281e-104	344.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,4H72I@909932|Negativicutes	909932|Negativicutes	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS2_k127_3398943_0	1232410.KI421413_gene611	7.38e-91	306.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,43S18@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Na+/Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
MMS2_k127_3398943_1	289376.THEYE_A1774	4.109e-59	212.0	COG0704@1|root,COG0704@2|Bacteria,3J0M6@40117|Nitrospirae	40117|Nitrospirae	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
MMS2_k127_3398943_2	642492.Clole_1140	1.16e-25	106.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS2_k127_3404961_5	891968.Anamo_0799	3.054e-16	79.0	COG0322@1|root,COG0322@2|Bacteria,3TA9X@508458|Synergistetes	508458|Synergistetes	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
MMS2_k127_3404961_1	756499.Desde_4229	1.319e-33	135.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,26287@186807|Peptococcaceae	186801|Clostridia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
MMS2_k127_3404961_4	689781.AUJX01000024_gene1145	2.567e-18	87.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,2PSI0@265975|Oribacterium	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
MMS2_k127_3404961_2	309799.DICTH_1248	3.213e-33	132.0	COG0629@1|root,COG0629@2|Bacteria	2|Bacteria	L	single-stranded DNA binding	ssbB	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
MMS2_k127_3404961_3	1379698.RBG1_1C00001G0504	5.872e-24	106.0	COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria	2|Bacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363,GO:1901576	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
MMS2_k127_3404961_6	401526.TcarDRAFT_0865	2.525e-11	68.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,4H57T@909932|Negativicutes	909932|Negativicutes	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
MMS2_k127_3404961_0	742743.HMPREF9453_00690	1.446e-34	134.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H2Z8@909932|Negativicutes	909932|Negativicutes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
MMS2_k127_341228_1	1415775.U729_705	1.013e-24	115.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,36ESA@31979|Clostridiaceae	186801|Clostridia	GK	ROK family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
MMS2_k127_341228_0	935948.KE386495_gene1553	3.962e-50	183.0	COG0864@1|root,COG0864@2|Bacteria,1V5TB@1239|Firmicutes,24HRD@186801|Clostridia,42G9E@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
MMS2_k127_343985_1	1122217.KB899570_gene972	8.442e-22	98.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4H53P@909932|Negativicutes	909932|Negativicutes	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
MMS2_k127_343985_0	273068.TTE1711	3.073e-122	401.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,42F8N@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
MMS2_k127_3440081_1	762903.Pedsa_2279	1.974e-18	96.0	COG3458@1|root,COG3458@2|Bacteria,4PNNU@976|Bacteroidetes	976|Bacteroidetes	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
MMS2_k127_3440081_0	1125863.JAFN01000001_gene3450	4.556e-71	245.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS2_k127_3444519_2	521011.Mpal_1421	1.723e-43	172.0	COG3291@1|root,COG3391@1|root,arCOG02508@2157|Archaea,arCOG03563@2157|Archaea,2Y2RX@28890|Euryarchaeota,2NAHT@224756|Methanomicrobia	224756|Methanomicrobia	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,PKD
MMS2_k127_3444519_0	521011.Mpal_1474	5.897e-85	294.0	COG0614@1|root,arCOG03561@1|root,arCOG03561@2157|Archaea,arCOG03611@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
MMS2_k127_3444519_1	521011.Mpal_0423	1.275e-81	286.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
MMS2_k127_3445496_0	656519.Halsa_0348	1.285e-149	481.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,3WABR@53433|Halanaerobiales	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS2_k127_3446847_0	555079.Toce_1670	0.0	1234.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
MMS2_k127_3446847_1	574087.Acear_0053	3.093e-32	128.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,3WABR@53433|Halanaerobiales	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS2_k127_3446847_2	643648.Slip_1412	4.999e-24	108.0	COG2968@1|root,COG2968@2|Bacteria,1VB7C@1239|Firmicutes,24MYD@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
MMS2_k127_3451898_4	1121324.CLIT_8c00400	1.614e-07	58.0	COG1664@1|root,COG1664@2|Bacteria,1V1NS@1239|Firmicutes,24TEV@186801|Clostridia,25U0C@186804|Peptostreptococcaceae	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3451898_3	716544.wcw_1355	3.197e-13	75.0	COG0727@1|root,COG0727@2|Bacteria,2JH33@204428|Chlamydiae	204428|Chlamydiae	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3451898_1	880073.Calab_2422	3.579e-77	278.0	COG1449@1|root,COG1449@2|Bacteria,2NQNB@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
MMS2_k127_3451898_0	671143.DAMO_1052	1.348e-122	402.0	COG1085@1|root,COG1085@2|Bacteria,2NQQM@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4921)	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0896	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
MMS2_k127_3451898_2	316067.Geob_1010	1.394e-13	79.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA-2	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Alpha-amylase,Glyco_transf_5,Glycos_transf_1
MMS2_k127_3473458_1	485913.Krac_11897	2.51e-15	80.0	COG0707@1|root,COG0707@2|Bacteria,2G6CA@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase 28 domain	-	-	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
MMS2_k127_3473458_0	945713.IALB_2002	7.793e-75	258.0	COG1087@1|root,COG1087@2|Bacteria	2|Bacteria	M	UDP-glucose 4-epimerase activity	galE	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_3482878_0	1121422.AUMW01000023_gene2750	3.27e-85	291.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,261UX@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47,6.2.1.14	ko:K00639,ko:K00652,ko:K01906	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03209,R03210,R10124	RC00004,RC00014,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
MMS2_k127_3482878_1	247490.KSU1_C0630	1.367e-40	158.0	COG0132@1|root,COG0132@2|Bacteria,2J026@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
MMS2_k127_3482878_2	574087.Acear_1901	5.097e-07	53.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_3497532_0	316058.RPB_0488	3.971e-37	153.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,3K6C3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
MMS2_k127_3497532_1	665952.HMPREF1015_01219	6.268e-37	149.0	COG0477@1|root,COG2814@2|Bacteria,1TPRN@1239|Firmicutes,4H9VV@91061|Bacilli,1ZAXQ@1386|Bacillus	91061|Bacilli	EGP	the major facilitator superfamily	yhcA	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
MMS2_k127_3500698_3	1166018.FAES_3790	4.162e-22	96.0	COG0535@1|root,COG0535@2|Bacteria,4NFRX@976|Bacteroidetes,47KUF@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
MMS2_k127_3500698_2	648996.Theam_0762	2.339e-27	120.0	COG1480@1|root,COG1480@2|Bacteria,2G4JD@200783|Aquificae	200783|Aquificae	S	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
MMS2_k127_3500698_0	663278.Ethha_0975	1.09e-87	301.0	COG1456@1|root,COG1456@2|Bacteria,1TPYJ@1239|Firmicutes,2588B@186801|Clostridia,3WHWI@541000|Ruminococcaceae	186801|Clostridia	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD
MMS2_k127_3500698_1	1195236.CTER_2595	2.004e-32	132.0	COG2768@1|root,COG2768@2|Bacteria,1UK08@1239|Firmicutes,25FG6@186801|Clostridia,3WK7Y@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_3500736_0	1536770.R50345_12145	1.799e-163	528.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,4HDVR@91061|Bacilli,275SH@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl transferase	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
MMS2_k127_3546753_0	879212.DespoDRAFT_03236	2.163e-15	86.0	2DUSZ@1|root,33S3X@2|Bacteria,1NTCE@1224|Proteobacteria,42Y92@68525|delta/epsilon subdivisions,2WU7K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3571959_0	304371.MCP_2511	4.079e-50	188.0	COG0842@1|root,arCOG01463@2157|Archaea,2XXQI@28890|Euryarchaeota,2N9MG@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
MMS2_k127_3571959_1	1304883.KI912532_gene866	2.431e-39	148.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,2KUZV@206389|Rhodocyclales	206389|Rhodocyclales	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
MMS2_k127_3593242_1	1157708.KB907469_gene41	5.922e-12	72.0	COG1357@1|root,COG5351@1|root,COG1357@2|Bacteria,COG5351@2|Bacteria,1N7U9@1224|Proteobacteria,2VNN1@28216|Betaproteobacteria,4AG9P@80864|Comamonadaceae	28216|Betaproteobacteria	S	pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169,Pentapeptide,Pentapeptide_4
MMS2_k127_3593242_0	237368.SCABRO_02249	1.211e-47	173.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_2
MMS2_k127_3596093_0	247490.KSU1_C1668	4.672e-185	592.0	COG3696@1|root,COG3696@2|Bacteria,2IX94@203682|Planctomycetes	203682|Planctomycetes	P	AcrB/AcrD/AcrF family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
MMS2_k127_359659_1	585425.KR52_04310	2.406e-22	106.0	COG4370@1|root,COG4370@2|Bacteria,1G0KE@1117|Cyanobacteria,1GZQY@1129|Synechococcus	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_359659_0	443254.Marpi_0817	1.961e-33	134.0	COG3842@1|root,COG3842@2|Bacteria,2GC81@200918|Thermotogae	200918|Thermotogae	P	ABC transporter	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE
MMS2_k127_360149_1	696281.Desru_1719	3.562e-27	113.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,262G6@186807|Peptococcaceae	186801|Clostridia	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
MMS2_k127_360149_0	635013.TherJR_2099	1.923e-152	492.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,260I6@186807|Peptococcaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
MMS2_k127_361302_0	941449.dsx2_1097	2.276e-43	168.0	COG0438@1|root,COG0438@2|Bacteria,1RFDR@1224|Proteobacteria,435R4@68525|delta/epsilon subdivisions,2X05N@28221|Deltaproteobacteria,2MAPI@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_361302_1	1471459.JFLJ01000132_gene1329	5.643e-08	58.0	COG0030@1|root,COG0030@2|Bacteria	2|Bacteria	J	rRNA (adenine-N6,N6-)-dimethyltransferase activity	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528,ko:K15256	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009,ko03016	-	-	-	Methyltransf_21,RrnaAD
MMS2_k127_3624838_1	1122185.N792_04265	7.163e-21	98.0	28H8Z@1|root,2ZC05@2|Bacteria,1RBDW@1224|Proteobacteria,1RXUP@1236|Gammaproteobacteria,1X4TV@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1282)	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
MMS2_k127_3624838_3	1120985.AUMI01000011_gene397	7.777e-05	55.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Phenol_MetA_deg
MMS2_k127_3624838_0	357809.Cphy_1356	8.874e-24	116.0	COG0457@1|root,COG0457@2|Bacteria,1UGB6@1239|Firmicutes,25NQ0@186801|Clostridia,2224M@1506553|Lachnoclostridium	186801|Clostridia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
MMS2_k127_3624838_2	1048983.EL17_05365	5.114e-09	58.0	COG0769@1|root,COG0769@2|Bacteria,4NE9W@976|Bacteroidetes,47JT3@768503|Cytophagia	976|Bacteroidetes	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS2_k127_363302_0	331678.Cphamn1_1066	5.343e-104	351.0	COG0841@1|root,COG0841@2|Bacteria,1FEYE@1090|Chlorobi	1090|Chlorobi	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS2_k127_3653375_1	1122135.KB893146_gene1574	3.273e-07	61.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	resE	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg,SSF
MMS2_k127_3653375_0	1297569.MESS2_790018	6.098e-08	57.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
MMS2_k127_3663597_2	1121877.JQKF01000002_gene1725	5.288e-14	72.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4CNHR@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II
MMS2_k127_3663597_0	632518.Calow_0495	4.469e-71	252.0	COG2222@1|root,COG2222@2|Bacteria,1TRBS@1239|Firmicutes,24A9W@186801|Clostridia,42EVQ@68295|Thermoanaerobacterales	186801|Clostridia	G	TIGRFAM bifunctional phosphoglucose phosphomannose isomerase	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
MMS2_k127_3663597_1	28072.Nos7524_2200	1.19e-56	206.0	COG0793@1|root,COG0793@2|Bacteria,1G1YJ@1117|Cyanobacteria,1HKZG@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41,Tricorn_C1
MMS2_k127_3701841_1	293826.Amet_3124	3.77e-06	49.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,36J0Z@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
MMS2_k127_3701841_0	1121422.AUMW01000030_gene58	3.383e-54	200.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
MMS2_k127_3714501_0	1232410.KI421424_gene1590	1.295e-42	165.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43C4K@68525|delta/epsilon subdivisions,2X7F1@28221|Deltaproteobacteria,43TX3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains HisKA, HATPase_c	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
MMS2_k127_3714501_2	645991.Sgly_3296	6.162e-15	81.0	COG0745@1|root,COG0745@2|Bacteria,1W37V@1239|Firmicutes,25FYR@186801|Clostridia,267F7@186807|Peptococcaceae	186801|Clostridia	KT	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
MMS2_k127_3714501_1	717606.PaecuDRAFT_2099	5.692e-27	119.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,4HAPK@91061|Bacilli,26V88@186822|Paenibacillaceae	91061|Bacilli	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
MMS2_k127_3732551_1	1131812.JQMS01000001_gene890	0.0001025	54.0	COG3307@1|root,COG3307@2|Bacteria,4NJTN@976|Bacteroidetes,1HZ54@117743|Flavobacteriia,2NYIV@237|Flavobacterium	976|Bacteroidetes	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
MMS2_k127_3732551_0	359.CN09_18200	2.618e-59	220.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,2TUG6@28211|Alphaproteobacteria,4BCJ2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_3737324_0	224324.aq_181	1.387e-83	280.0	COG0107@1|root,COG0107@2|Bacteria,2G3N6@200783|Aquificae	200783|Aquificae	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
MMS2_k127_3737324_1	667014.Thein_1539	1.53e-66	236.0	COG0142@1|root,COG0142@2|Bacteria,2GHPM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS2_k127_3744713_1	485916.Dtox_0206	2.585e-31	126.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,2605Q@186807|Peptococcaceae	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
MMS2_k127_3744713_0	1122947.FR7_3525	1.824e-116	387.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,4H2NA@909932|Negativicutes	909932|Negativicutes	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
MMS2_k127_3748479_4	269799.Gmet_2849	1.697e-09	61.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2WNJR@28221|Deltaproteobacteria,43TCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_3748479_3	1120983.KB894572_gene2900	6.343e-13	79.0	2F92N@1|root,341EA@2|Bacteria,1Q6PW@1224|Proteobacteria,2VCT1@28211|Alphaproteobacteria,1JQD6@119043|Rhodobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3748479_2	1122223.KB890700_gene2056	1.321e-26	121.0	COG0686@1|root,COG0686@2|Bacteria,1WIQ6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
MMS2_k127_3748479_1	869210.Marky_1253	4.285e-30	131.0	COG0686@1|root,COG0686@2|Bacteria,1WIQ6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
MMS2_k127_3748479_0	237368.SCABRO_02886	6.132e-48	177.0	COG1611@1|root,COG1611@2|Bacteria,2IXIR@203682|Planctomycetes	203682|Planctomycetes	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
MMS2_k127_376289_1	1313172.YM304_20400	6.782e-10	63.0	COG3463@1|root,COG3463@2|Bacteria	2|Bacteria	T	Predicted membrane protein (DUF2079)	-	-	2.7.13.3	ko:K07778	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2079,HisKA_3
MMS2_k127_376289_0	665571.STHERM_c17660	2.833e-90	308.0	COG0463@1|root,COG0463@2|Bacteria,2J7NM@203691|Spirochaetes	203691|Spirochaetes	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721,ko:K20534	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
MMS2_k127_3763098_0	706587.Desti_0849	1.49e-48	192.0	COG3290@1|root,COG4191@1|root,COG4251@1|root,COG3290@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,42QA2@68525|delta/epsilon subdivisions,2X7QC@28221|Deltaproteobacteria,2MRGM@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
MMS2_k127_3778679_1	204669.Acid345_4505	1.383e-26	110.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria,2JJPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
MMS2_k127_3778679_0	1121428.DESHY_160226___1	1.646e-111	368.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,2600J@186807|Peptococcaceae	186801|Clostridia	S	PFAM 2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
MMS2_k127_3798749_0	485913.Krac_7975	6.331e-34	144.0	COG0535@1|root,COG0535@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
MMS2_k127_3798749_1	1121440.AUMA01000002_gene2129	1.774e-12	77.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42TFM@68525|delta/epsilon subdivisions,2WPBE@28221|Deltaproteobacteria,2MCE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS2_k127_3810244_1	926692.AZYG01000085_gene802	3.545e-32	128.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3WA8M@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_3810244_0	1341151.ASZU01000003_gene2594	2.351e-97	329.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,4H9MX@91061|Bacilli,27BA9@186824|Thermoactinomycetaceae	91061|Bacilli	E	Aminomethyltransferase folate-binding domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
MMS2_k127_3810244_2	931626.Awo_c32810	4.367e-06	48.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,25XF3@186806|Eubacteriaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS2_k127_3813254_3	646529.Desaci_3283	2.784e-36	141.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,2620J@186807|Peptococcaceae	186801|Clostridia	M	transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
MMS2_k127_3813254_0	742738.HMPREF9460_01482	7.155e-144	464.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,267PK@186813|unclassified Clostridiales	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
MMS2_k127_3813254_1	1209989.TepiRe1_0721	1.107e-61	220.0	COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,42GD7@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
MMS2_k127_3813254_2	525904.Tter_0808	6.973e-50	184.0	COG0639@1|root,COG0639@2|Bacteria,2NPHT@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
MMS2_k127_3830842_0	1304284.L21TH_0394	6.833e-47	174.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia,36F38@31979|Clostridiaceae	186801|Clostridia	G	hydrolase family 65, central catalytic	kojP	-	2.4.1.230	ko:K10231	-	-	-	-	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
MMS2_k127_3830842_1	349520.PPE_01196	7.718e-43	164.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HF93@91061|Bacilli,26R68@186822|Paenibacillaceae	91061|Bacilli	G	deacetylase	pdaC	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
MMS2_k127_3830842_2	402880.MmarC5_1409	7.952e-22	100.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota,23QB0@183939|Methanococci	183939|Methanococci	M	PFAM MscS Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMS2_k127_3859082_1	251221.35214051	2.828e-41	160.0	COG1316@1|root,COG1316@2|Bacteria,1G0TR@1117|Cyanobacteria	1117|Cyanobacteria	K	TIGRFAM cell envelope-related function transcriptional attenuator common domain	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
MMS2_k127_3859082_0	309799.DICTH_1509	5.99e-48	180.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS2_k127_3859082_2	986075.CathTA2_2108	4.66e-24	105.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,4HH8I@91061|Bacilli	91061|Bacilli	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
MMS2_k127_3868380_4	1209989.TepiRe1_2371	1.256e-35	138.0	COG1014@1|root,COG1014@2|Bacteria,1TRFJ@1239|Firmicutes,24A29@186801|Clostridia,42GE2@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
MMS2_k127_3868380_5	1158318.ATXC01000001_gene168	1.413e-31	125.0	COG1144@1|root,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K00172,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,Fer4_21,POR
MMS2_k127_3868380_1	926692.AZYG01000051_gene1858	7.19e-147	475.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WAF8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMS2_k127_3868380_3	555079.Toce_2138	9.915e-125	410.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,42F9H@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Thiamine pyrophosphate	porB	-	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS2_k127_3868380_6	1121121.KB894286_gene2450	2.759e-20	95.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,4HKF2@91061|Bacilli,26Y3J@186822|Paenibacillaceae	91061|Bacilli	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hbs	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS2_k127_3868380_0	515635.Dtur_0786	6.938e-171	550.0	COG1847@1|root,COG3854@1|root,COG1847@2|Bacteria,COG3854@2|Bacteria	2|Bacteria	S	ATPases associated with a variety of cellular activities	ycf45	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
MMS2_k127_3868380_2	748449.Halha_1151	3.4e-134	445.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3WAHG@53433|Halanaerobiales	186801|Clostridia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS2_k127_3871425_1	357808.RoseRS_2786	5.858e-53	203.0	COG1520@1|root,COG1520@2|Bacteria,2G9GE@200795|Chloroflexi,3774I@32061|Chloroflexia	32061|Chloroflexia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3871425_2	1408322.JHYK01000020_gene294	1.84e-08	66.0	COG5279@1|root,COG5279@2|Bacteria,1UPJ0@1239|Firmicutes,25HHJ@186801|Clostridia,27QID@186928|unclassified Lachnospiraceae	186801|Clostridia	D	Listeria-Bacteroides repeat domain (List_Bact_rpt)	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new
MMS2_k127_3871425_0	289376.THEYE_A0785	3.851e-157	506.0	COG0119@1|root,COG0119@2|Bacteria,3J0DC@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
MMS2_k127_3890741_0	1121428.DESHY_110426___1	7.978e-42	169.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,24BSX@186801|Clostridia,26137@186807|Peptococcaceae	186801|Clostridia	T	PAS domain	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
MMS2_k127_3907487_0	459349.CLOAM0430	2.533e-10	72.0	COG2067@1|root,COG2067@2|Bacteria,2NQZT@2323|unclassified Bacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3907487_1	1379698.RBG1_1C00001G1789	0.0005528	49.0	COG1572@1|root,COG1572@2|Bacteria,2NP03@2323|unclassified Bacteria	2|Bacteria	S	Propeptide_C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
MMS2_k127_3918812_0	1122947.FR7_1434	6.261e-81	282.0	COG0019@1|root,COG0019@2|Bacteria,1TQIQ@1239|Firmicutes,4H2QF@909932|Negativicutes	909932|Negativicutes	E	Belongs to the Orn Lys Arg decarboxylase class-II family	ldc	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
MMS2_k127_3925775_0	767817.Desgi_1299	4.084e-71	256.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,26014@186807|Peptococcaceae	186801|Clostridia	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
MMS2_k127_3927988_0	1047013.AQSP01000122_gene2257	3.184e-28	130.0	COG1186@1|root,COG1186@2|Bacteria	2|Bacteria	J	translation release factor activity	prfA3	-	-	-	-	-	-	-	-	-	-	-	RF-1
MMS2_k127_3928435_0	1123511.KB905871_gene66	9.749e-112	373.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,4H2GR@909932|Negativicutes	909932|Negativicutes	H	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
MMS2_k127_3929694_1	511062.GU3_08615	8.023e-10	65.0	COG3108@1|root,COG3108@2|Bacteria,1N6F7@1224|Proteobacteria,1SBQ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
MMS2_k127_3929694_0	243164.DET0716	1.698e-52	193.0	COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,34CTP@301297|Dehalococcoidia	301297|Dehalococcoidia	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
MMS2_k127_3932600_0	857293.CAAU_1053	1.066e-128	420.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,36E95@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
MMS2_k127_3933212_0	243274.THEMA_04930	2.259e-114	377.0	COG3459@1|root,COG3459@2|Bacteria,2GCQM@200918|Thermotogae	200918|Thermotogae	G	Cellobiose phosphorylase	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	Glyco_hydro_36,Glyco_transf_36
MMS2_k127_3933212_1	153721.MYP_3691	1.321e-20	98.0	COG3934@1|root,COG3934@2|Bacteria,4NFVS@976|Bacteroidetes,47KA9@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
MMS2_k127_39338_1	309799.DICTH_1745	1.365e-26	111.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	envC_2	-	3.4.24.75	ko:K08259,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
MMS2_k127_39338_2	273068.TTE0840	7.974e-20	94.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,42GQS@68295|Thermoanaerobacterales	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS2_k127_39338_0	429009.Adeg_2117	1.067e-47	175.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,42F0X@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
MMS2_k127_3954707_0	864702.OsccyDRAFT_3012	6.72e-23	113.0	COG3463@1|root,COG3463@2|Bacteria,1G2XA@1117|Cyanobacteria,1H828@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane protein (DUF2079)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
MMS2_k127_3961460_0	1333998.M2A_1792	5.552e-103	346.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,4BPW3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	merA	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS2_k127_3967677_0	1155718.KB891891_gene7069	7.781e-19	99.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
MMS2_k127_3979231_0	671143.DAMO_0297	7.326e-67	235.0	COG5617@1|root,COG5617@2|Bacteria	2|Bacteria	M	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
MMS2_k127_3992545_2	1048834.TC41_2003	1.324e-42	160.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4HAB1@91061|Bacilli,277YK@186823|Alicyclobacillaceae	91061|Bacilli	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	iSB619.SA_RS06920	ABC_tran
MMS2_k127_3992545_0	862908.BMS_2386	1.929e-88	300.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2MT44@213481|Bdellovibrionales,2WMUA@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	TIGRFAM phosphate ABC transporter	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS2_k127_3992545_1	768704.Desmer_2751	9.135e-86	292.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,26553@186807|Peptococcaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS2_k127_3992545_3	1201288.M900_1880	1.867e-06	51.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS2_k127_400253_1	1423321.AS29_13285	7.284e-40	154.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,4H9TQ@91061|Bacilli,1ZAU3@1386|Bacillus	91061|Bacilli	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
MMS2_k127_400253_0	1125863.JAFN01000001_gene2582	7.012e-65	230.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
MMS2_k127_4022719_0	596151.DesfrDRAFT_2813	1.592e-84	285.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2M8UV@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
MMS2_k127_404500_0	441769.ABFU01000037_gene276	4.994e-93	313.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,4HBHZ@91061|Bacilli,1ZBP0@1386|Bacillus	91061|Bacilli	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS2_k127_4072860_1	1123248.KB893331_gene3781	1.27e-15	80.0	COG0535@1|root,COG0535@2|Bacteria,4NGWY@976|Bacteroidetes,1IWI9@117747|Sphingobacteriia	976|Bacteroidetes	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS2_k127_4072860_0	1131269.AQVV01000013_gene1730	8.443e-48	186.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	lpsE	-	2.7.8.12	ko:K09809	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glyphos_transf
MMS2_k127_4075530_2	1209989.TepiRe1_0311	7.248e-09	62.0	COG1633@1|root,COG1633@2|Bacteria,1VJA4@1239|Firmicutes,24TWK@186801|Clostridia,42IAM@68295|Thermoanaerobacterales	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS2_k127_4075530_1	511051.CSE_11560	1.716e-36	147.0	COG1394@1|root,COG1394@2|Bacteria	2|Bacteria	C	ATPase activity, coupled to transmembrane movement of substances	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS2_k127_4075530_0	555088.DealDRAFT_1678	6.97e-154	490.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_4078289_0	626939.HMPREF9443_00670	3.402e-75	257.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H278@909932|Negativicutes	909932|Negativicutes	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS2_k127_4130388_0	747365.Thena_0719	5.381e-119	398.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,42EPS@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366,ko:K21464	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
MMS2_k127_4132597_1	4577.GRMZM2G180863_P01	3.408e-40	152.0	COG0462@1|root,KOG1448@2759|Eukaryota,37RIN@33090|Viridiplantae,3GEMM@35493|Streptophyta,3KY2N@4447|Liliopsida,3I2GQ@38820|Poales	35493|Streptophyta	EF	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
MMS2_k127_4132597_0	401526.TcarDRAFT_2056	8.596e-114	381.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,4H1VJ@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
MMS2_k127_4132597_2	309803.CTN_1231	1.489e-17	87.0	COG0745@1|root,COG0745@2|Bacteria,2GD9E@200918|Thermotogae	200918|Thermotogae	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
MMS2_k127_4132597_3	374847.Kcr_0466	2.736e-14	74.0	COG1872@1|root,arCOG04058@2157|Archaea	2157|Archaea	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMS2_k127_4132597_4	35725.K2RBE2	7.779e-13	78.0	COG0823@1|root,2QPTW@2759|Eukaryota,38RVS@33154|Opisthokonta,3NZ8B@4751|Fungi,3QSE5@4890|Ascomycota,20410@147541|Dothideomycetes	4751|Fungi	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
MMS2_k127_4133833_0	1121472.AQWN01000005_gene2400	3.907e-129	419.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,260UE@186807|Peptococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS2_k127_4133833_1	573413.Spirs_1744	1.272e-31	131.0	COG0811@1|root,COG0811@2|Bacteria,2J7EN@203691|Spirochaetes	203691|Spirochaetes	U	MotA TolQ ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
MMS2_k127_4133833_3	1408287.AXUR01000030_gene1528	2.408e-09	64.0	COG0848@1|root,COG0848@2|Bacteria,37A3D@32066|Fusobacteria	32066|Fusobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
MMS2_k127_4133833_2	394.NGR_c24550	9.086e-10	66.0	COG0810@1|root,COG0810@2|Bacteria,1RESZ@1224|Proteobacteria,2UAM6@28211|Alphaproteobacteria,4BMTN@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
MMS2_k127_4133833_4	243231.GSU2708	3.965e-06	49.0	COG2221@1|root,COG2221@2|Bacteria,1QXPA@1224|Proteobacteria,42X12@68525|delta/epsilon subdivisions,2X7FG@28221|Deltaproteobacteria,43VTB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	frx-2	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1033	Fer4
MMS2_k127_4136352_2	290317.Cpha266_1942	8.21e-06	58.0	COG1452@1|root,COG1452@2|Bacteria,1FD7H@1090|Chlorobi	1090|Chlorobi	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4136352_0	1380393.JHVP01000008_gene4512	8.599e-51	186.0	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG0477@2|Bacteria,2GNTI@201174|Actinobacteria,4ES48@85013|Frankiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
MMS2_k127_4136352_1	248742.XP_005645067.1	9.263e-26	108.0	COG0013@1|root,KOG0188@2759|Eukaryota,37PCW@33090|Viridiplantae,34GPT@3041|Chlorophyta	3041|Chlorophyta	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS2_k127_4142277_0	1111134.HMPREF1253_0522	3.021e-239	749.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,22GFK@1570339|Peptoniphilaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS2_k127_4145280_0	215803.DB30_6768	2.646e-21	104.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,42ME7@68525|delta/epsilon subdivisions,2WSJG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS2_k127_4145280_1	926692.AZYG01000041_gene1605	4.85e-12	68.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,3WC55@53433|Halanaerobiales	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
MMS2_k127_4145280_2	592015.HMPREF1705_01570	2.218e-06	51.0	COG0690@1|root,COG0690@2|Bacteria,3TBK4@508458|Synergistetes	508458|Synergistetes	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
MMS2_k127_4151909_2	1122927.KB895415_gene4583	5.622e-08	57.0	2E46D@1|root,32Z2B@2|Bacteria,1VEH0@1239|Firmicutes,4HPNF@91061|Bacilli,26Z5F@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4151909_0	247490.KSU1_D0387	2.197e-202	637.0	COG0499@1|root,COG0499@2|Bacteria,2IXKQ@203682|Planctomycetes	203682|Planctomycetes	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMS2_k127_4151909_1	1121472.AQWN01000005_gene2425	2.443e-93	317.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,2606P@186807|Peptococcaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
MMS2_k127_4157051_0	857293.CAAU_2079	1.713e-85	291.0	COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,24AQ7@186801|Clostridia,36KHB@31979|Clostridiaceae	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17313	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	BPD_transp_1
MMS2_k127_4157051_1	986075.CathTA2_3062	1.056e-25	109.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,4HBIM@91061|Bacilli	91061|Bacilli	G	ABC transporter (Permease	sugA_2	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
MMS2_k127_418054_0	203119.Cthe_0686	3.685e-131	424.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3WGS4@541000|Ruminococcaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS2_k127_418363_0	234267.Acid_5965	3.808e-08	64.0	COG2374@1|root,COG3386@1|root,COG2374@2|Bacteria,COG3386@2|Bacteria,3Y6HZ@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	DUF1573,Exo_endo_phos,LTD
MMS2_k127_4184934_1	1408422.JHYF01000016_gene110	7.207e-25	108.0	COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,36DPA@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
MMS2_k127_4184934_0	1128421.JAGA01000003_gene3015	5.839e-73	254.0	COG0284@1|root,COG0461@1|root,COG0284@2|Bacteria,COG0461@2|Bacteria,2NP92@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrE	GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10,4.1.1.23	ko:K00762,ko:K01591,ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585,iYO844.BSU15560	OMPdecase,Pribosyltran
MMS2_k127_419514_0	1089550.ATTH01000001_gene2273	6.189e-08	64.0	COG5448@1|root,COG5448@2|Bacteria,4NGRS@976|Bacteroidetes,1FJ4S@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Glycoside hydrolase family 24	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4203355_1	938709.AUSH02000020_gene2010	1.655e-05	49.0	COG4409@1|root,COG4409@2|Bacteria,4PM7K@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 18 family	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10,fn3
MMS2_k127_4203355_0	871963.Desdi_1163	3.948e-124	406.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS2_k127_4204196_2	572479.Hprae_0030	1.884e-30	123.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,3WAS3@53433|Halanaerobiales	186801|Clostridia	S	PFAM MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	ACT,ACT_4,MgtC
MMS2_k127_4204196_1	1121472.AQWN01000002_gene2287	1.278e-68	237.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24F1M@186801|Clostridia,261IT@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
MMS2_k127_4204196_0	747365.Thena_1393	2.641e-99	345.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42EQB@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_4208287_1	555088.DealDRAFT_1958	6.53e-49	184.0	COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,24HQS@186801|Clostridia,42JWW@68298|Syntrophomonadaceae	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
MMS2_k127_4208287_0	1122947.FR7_3293	1.624e-61	219.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,4H1Y3@909932|Negativicutes	909932|Negativicutes	J	elongation factor G	fusA_1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS2_k127_4211628_0	272563.CD630_21160	8.033e-138	447.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,25QE6@186804|Peptostreptococcaceae	186801|Clostridia	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
MMS2_k127_4211841_0	1120973.AQXL01000101_gene1167	6.839e-65	232.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,277ZT@186823|Alicyclobacillaceae	91061|Bacilli	L	DHH family	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
MMS2_k127_4212169_1	411459.RUMOBE_03896	0.0005081	44.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,3XYU9@572511|Blautia	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMS2_k127_4212169_0	111780.Sta7437_3456	2.327e-126	413.0	COG1052@1|root,COG1052@2|Bacteria,1GCIT@1117|Cyanobacteria,3VIQ1@52604|Pleurocapsales	1117|Cyanobacteria	E	PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
MMS2_k127_4237112_0	1123288.SOV_1c09960	4.742e-54	199.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4H1XX@909932|Negativicutes	909932|Negativicutes	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS2_k127_424182_0	748449.Halha_2433	3.888e-25	121.0	COG1452@1|root,COG1452@2|Bacteria,1W2IS@1239|Firmicutes	1239|Firmicutes	M	Organic solvent tolerance protein OstA	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
MMS2_k127_4247555_0	555079.Toce_1188	1.581e-123	414.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,42ENI@68295|Thermoanaerobacterales	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
MMS2_k127_4247555_1	264732.Moth_1026	2.751e-87	297.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,42EVH@68295|Thermoanaerobacterales	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS2_k127_4271550_1	205918.Psyr_4601	5.153e-05	47.0	2B7K3@1|root,320R0@2|Bacteria,1P97U@1224|Proteobacteria	1224|Proteobacteria	S	Mu-like prophage protein Com	-	-	-	-	-	-	-	-	-	-	-	-	Mu-like_Com
MMS2_k127_4271550_0	478801.Ksed_12500	2.042e-73	254.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,1ZWG5@145357|Dermacoccaceae	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS2_k127_4297668_1	1262915.BN574_00800	7.118e-51	194.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H2U9@909932|Negativicutes	909932|Negativicutes	M	Glycosyltransferase, group 4 family	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
MMS2_k127_4297668_2	1120972.AUMH01000006_gene1797	6.648e-32	127.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,4HKEK@91061|Bacilli	91061|Bacilli	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
MMS2_k127_4297668_0	747365.Thena_0044	1.662e-67	233.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,42EQM@68295|Thermoanaerobacterales	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
MMS2_k127_4300663_0	1262914.BN533_00255	1.64e-195	623.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,4H32N@909932|Negativicutes	909932|Negativicutes	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA-synt_2d,tRNA_anti-codon
MMS2_k127_4300663_3	1121423.JONT01000028_gene669	7.018e-15	87.0	COG0823@1|root,COG3291@1|root,COG4254@1|root,COG0823@2|Bacteria,COG3291@2|Bacteria,COG4254@2|Bacteria	2|Bacteria	UW	PFAM FecR protein	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	DUF5050,FecR,PKD,Peptidase_M9
MMS2_k127_4300663_1	498761.HM1_0977	1.723e-160	516.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMS2_k127_4300663_2	118168.MC7420_1162	1.02e-49	181.0	COG0603@1|root,COG0603@2|Bacteria,1G24C@1117|Cyanobacteria,1H9ZJ@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS2_k127_4309289_0	1123290.AUDQ01000003_gene667	2.059e-27	122.0	COG4786@1|root,COG4786@2|Bacteria,1TRA2@1239|Firmicutes,4HBNB@91061|Bacilli,26D5Z@186818|Planococcaceae	91061|Bacilli	N	Flagellar basal body	flgG	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
MMS2_k127_4309289_1	754027.HMPREF9554_02855	0.0004264	51.0	COG1868@1|root,COG1868@2|Bacteria,2J5WR@203691|Spirochaetes	203691|Spirochaetes	N	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
MMS2_k127_4316943_2	1304872.JAGC01000003_gene3788	2.502e-44	164.0	COG0662@1|root,COG0662@2|Bacteria,1QTZV@1224|Proteobacteria,42RQ1@68525|delta/epsilon subdivisions,2WNQD@28221|Deltaproteobacteria,2MC82@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	WxcM-like, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FdtA
MMS2_k127_4316943_0	882086.SacxiDRAFT_0079	6.564e-129	425.0	2CCXX@1|root,2Z8MY@2|Bacteria,2GK82@201174|Actinobacteria,4DY84@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM NDP-hexose 2,3-dehydratase	-	-	4.2.1.159	ko:K16435	ko00523,ko01055,ko01130,map00523,map01055,map01130	M00798,M00799,M00800,M00801,M00802,M00803	R05518,R06428	RC00782,RC01448	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexose_dehydrat
MMS2_k127_4316943_1	596151.DesfrDRAFT_3996	1.88e-67	241.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,43E7I@68525|delta/epsilon subdivisions,2X39F@28221|Deltaproteobacteria,2M8XH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM oxidoreductase domain protein	-	-	1.1.1.384	ko:K13327	ko00523,ko01130,map00523,map01130	M00801,M00802	R05526	RC00897	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS2_k127_4316943_3	1410633.JHWR01000004_gene273	8.792e-10	68.0	COG1083@1|root,COG1083@2|Bacteria	2|Bacteria	M	cytidylyl-transferase	-	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3,Glycos_transf_2
MMS2_k127_4316943_4	1122919.KB905548_gene2331	5.356e-07	55.0	COG1233@1|root,COG3349@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,1UURR@1239|Firmicutes,4I6S6@91061|Bacilli,26UNA@186822|Paenibacillaceae	91061|Bacilli	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
MMS2_k127_4332818_2	926692.AZYG01000096_gene1896	2.254e-12	78.0	29X6V@1|root,30IW1@2|Bacteria,1VY2J@1239|Firmicutes,251WA@186801|Clostridia,3WBY0@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4332818_1	857293.CAAU_2094	2.953e-55	200.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
MMS2_k127_4332818_3	1166948.JPZL01000003_gene641	1.142e-05	51.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1XM4G@135619|Oceanospirillales	135619|Oceanospirillales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
MMS2_k127_4332818_0	509191.AEDB02000065_gene621	5.675e-107	357.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,3WGXA@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS2_k127_4335953_1	1128421.JAGA01000002_gene1657	7.646e-14	72.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	lspL	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_4335953_0	1395587.P364_0124680	3.483e-135	443.0	COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,4HADP@91061|Bacilli,26Q8V@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	tuaD	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
MMS2_k127_4355404_0	1121342.AUCO01000025_gene1422	2.453e-171	547.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,36EKI@31979|Clostridiaceae	186801|Clostridia	C	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS2_k127_4355404_1	1121373.KB903620_gene2118	5.314e-36	139.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,4NFKH@976|Bacteroidetes,47JB7@768503|Cytophagia	976|Bacteroidetes	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
MMS2_k127_4367328_2	118168.MC7420_6216	1.117e-06	52.0	COG0668@1|root,COG0668@2|Bacteria,1G08V@1117|Cyanobacteria,1H971@1150|Oscillatoriales	1117|Cyanobacteria	M	mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
MMS2_k127_4367328_0	1123229.AUBC01000001_gene1837	1.845e-21	102.0	2E61B@1|root,330QK@2|Bacteria,1N39M@1224|Proteobacteria,2U8C9@28211|Alphaproteobacteria,3JZ9V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4367328_1	515635.Dtur_0906	8.115e-21	94.0	COG1704@1|root,COG1704@2|Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
MMS2_k127_4384222_0	693661.Arcve_0646	9.167e-38	145.0	arCOG06733@1|root,arCOG06733@2157|Archaea,2Y62E@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4384222_1	1267534.KB906754_gene3160	1.373e-34	135.0	2EE2W@1|root,337XH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4384222_2	404380.Gbem_2560	2.912e-19	89.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,42QWQ@68525|delta/epsilon subdivisions,2WMRI@28221|Deltaproteobacteria,43T93@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4396239_2	1449126.JQKL01000050_gene2676	1.986e-13	71.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,268PJ@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMS2_k127_4396239_0	373994.Riv7116_2636	4.624e-71	246.0	COG0087@1|root,COG0087@2|Bacteria,1FZY5@1117|Cyanobacteria,1HJ2K@1161|Nostocales	1117|Cyanobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMS2_k127_4396239_1	1111479.AXAR01000008_gene2359	1.345e-43	160.0	COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,4HIKH@91061|Bacilli,278F7@186823|Alicyclobacillaceae	91061|Bacilli	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMS2_k127_4396739_4	1303518.CCALI_02895	2.101e-16	83.0	COG0103@1|root,COG0103@2|Bacteria	2|Bacteria	J	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS2_k127_4396739_2	1268635.Loa_02686	1.031e-49	180.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1JDF4@118969|Legionellales	118969|Legionellales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS2_k127_4396739_3	1121423.JONT01000027_gene631	3.405e-25	108.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,2621E@186807|Peptococcaceae	186801|Clostridia	J	PFAM ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
MMS2_k127_4396739_0	1121335.Clst_2503	3.607e-99	332.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,3WGUM@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
MMS2_k127_4396739_1	635013.TherJR_0323	5.417e-60	212.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,260U9@186807|Peptococcaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMS2_k127_4397441_2	502025.Hoch_4816	1.773e-06	55.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019,GerE,Response_reg
MMS2_k127_4397441_1	882082.SaccyDRAFT_3508	2.284e-47	185.0	COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,4DYMP@85010|Pseudonocardiales	201174|Actinobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
MMS2_k127_4397441_0	1348663.KCH_46870	1.643e-66	231.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,2M20P@2063|Kitasatospora	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
MMS2_k127_4410450_0	404380.Gbem_2714	4.291e-107	359.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2WJZR@28221|Deltaproteobacteria,43TIN@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
MMS2_k127_4410450_1	118168.MC7420_6216	6.085e-103	342.0	COG0668@1|root,COG0668@2|Bacteria,1G08V@1117|Cyanobacteria,1H971@1150|Oscillatoriales	1117|Cyanobacteria	M	mechanosensitive ion channel	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
MMS2_k127_4410900_0	697281.Mahau_1630	1.318e-55	198.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,42EZN@68295|Thermoanaerobacterales	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
MMS2_k127_4410900_1	517418.Ctha_0299	0.000336	52.0	COG4254@1|root,COG4254@2|Bacteria,1FEZE@1090|Chlorobi	1090|Chlorobi	S	PFAM FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_441490_1	582515.KR51_00032970	3.853e-45	170.0	COG0438@1|root,COG0438@2|Bacteria,1GF7V@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_441490_0	1121406.JAEX01000001_gene73	7.506e-80	269.0	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,43BNE@68525|delta/epsilon subdivisions,2WKIX@28221|Deltaproteobacteria,2M9U6@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_4415137_1	484770.UFO1_2541	2.079e-42	165.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,4H4UZ@909932|Negativicutes	909932|Negativicutes	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
MMS2_k127_4415137_0	926560.KE387023_gene3851	5.96e-79	273.0	COG0157@1|root,COG0157@2|Bacteria,1WIHZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
MMS2_k127_4417675_1	349161.Dred_1259	9.69e-77	263.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,2606G@186807|Peptococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
MMS2_k127_4417675_0	635013.TherJR_1599	1.168e-137	445.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,260FR@186807|Peptococcaceae	186801|Clostridia	E	PFAM DAHP synthetase I	aroF1	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS2_k127_4417675_2	429009.Adeg_1290	9.548e-39	147.0	COG4401@1|root,COG4401@2|Bacteria,1VAID@1239|Firmicutes,24N1H@186801|Clostridia,42H1D@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis	aroH	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
MMS2_k127_4417675_3	1121468.AUBR01000035_gene1408	1.727e-36	143.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,42F0N@68295|Thermoanaerobacterales	186801|Clostridia	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
MMS2_k127_4417675_4	574087.Acear_2174	1.973e-17	95.0	COG3203@1|root,COG3203@2|Bacteria,1VEU4@1239|Firmicutes,24SCU@186801|Clostridia,3WCBJ@53433|Halanaerobiales	186801|Clostridia	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3373,SLH
MMS2_k127_4422789_0	1128421.JAGA01000003_gene2772	6.841e-96	320.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA2	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_4422789_1	572479.Hprae_0257	2e-10	67.0	COG1560@1|root,COG1560@2|Bacteria,1TT7A@1239|Firmicutes,24HMK@186801|Clostridia,3WANH@53433|Halanaerobiales	186801|Clostridia	M	PFAM Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
MMS2_k127_4435099_0	880073.Calab_2124	3.493e-83	278.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484	-	ko:K02358,ko:K15771	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147	3.A.1.1.16,3.A.1.1.2	-	iSB619.SA_RS02960	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMS2_k127_4435099_1	351627.Csac_1552	5.985e-12	75.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,42EY6@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM VanW family protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
MMS2_k127_4438435_1	592029.DDD_3113	3.471e-09	69.0	COG4076@1|root,COG4076@2|Bacteria,4NSG2@976|Bacteroidetes,1IK7G@117743|Flavobacteriia	976|Bacteroidetes	Q	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PRMT5
MMS2_k127_4438435_0	555088.DealDRAFT_1842	1.013e-165	527.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,42KF3@68298|Syntrophomonadaceae	186801|Clostridia	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
MMS2_k127_444032_1	868131.MSWAN_2421	1.129e-36	143.0	COG1968@1|root,arCOG04761@2157|Archaea,2XTYX@28890|Euryarchaeota,23NY7@183925|Methanobacteria	183925|Methanobacteria	I	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP)	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
MMS2_k127_444032_0	373903.Hore_12250	6.69e-75	261.0	COG0341@1|root,COG0341@2|Bacteria,1TSZE@1239|Firmicutes,249A3@186801|Clostridia,3WAGZ@53433|Halanaerobiales	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
MMS2_k127_4440674_0	593750.Metfor_1598	1.324e-26	123.0	COG3291@1|root,COG5276@1|root,arCOG02516@1|root,arCOG02914@1|root,arCOG04005@1|root,arCOG02510@2157|Archaea,arCOG02516@2157|Archaea,arCOG02565@2157|Archaea,arCOG02914@2157|Archaea,arCOG04005@2157|Archaea	2157|Archaea	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,LVIVD,PKD
MMS2_k127_4440674_1	880073.Calab_2217	2.987e-09	63.0	COG2067@1|root,COG2067@2|Bacteria,2NRA4@2323|unclassified Bacteria	2|Bacteria	I	PFAM Uncharacterised protein family (UPF0164)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0164
MMS2_k127_4453693_1	383372.Rcas_3354	1.148e-14	81.0	COG4485@1|root,COG4485@2|Bacteria,2G75F@200795|Chloroflexi,3771H@32061|Chloroflexia	32061|Chloroflexia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
MMS2_k127_4453693_0	909663.KI867151_gene3116	1.239e-53	210.0	COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,42WPS@68525|delta/epsilon subdivisions,2WS8D@28221|Deltaproteobacteria,2MS9Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
MMS2_k127_4467479_0	1229172.JQFA01000004_gene1368	1.674e-06	59.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1H9S6@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.15,4.1.1.29,4.1.1.86	ko:K01580,ko:K01594,ko:K13745	ko00250,ko00260,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00260,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466,R07650	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
MMS2_k127_448217_0	1291050.JAGE01000002_gene3781	1.191e-42	171.0	COG3405@1|root,COG3405@2|Bacteria,1VARG@1239|Firmicutes,24BG1@186801|Clostridia,3WK66@541000|Ruminococcaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	Dockerin_1,Glyco_hydro_8
MMS2_k127_449406_0	1031288.AXAA01000011_gene602	1.639e-127	420.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,36DQF@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS2_k127_449406_3	97138.C820_01682	2.277e-23	104.0	COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,36EY8@31979|Clostridiaceae	186801|Clostridia	S	Radical SAM-linked protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
MMS2_k127_449406_2	720554.Clocl_1209	3.387e-26	113.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,3WJUU@541000|Ruminococcaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
MMS2_k127_449406_1	1430440.MGMSRv2_1765	1.805e-28	117.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,2JTA7@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
MMS2_k127_4497755_0	1341151.ASZU01000008_gene1429	8.023e-90	299.0	COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,4H9XB@91061|Bacilli,27B2U@186824|Thermoactinomycetaceae	91061|Bacilli	K	Rho termination factor, N-terminal domain	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
MMS2_k127_4497755_1	1304880.JAGB01000002_gene1521	3.079e-35	138.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS2_k127_4501142_3	37659.JNLN01000001_gene2283	8.734e-20	89.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,36KHC@31979|Clostridiaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
MMS2_k127_4501142_0	1449336.JQLO01000001_gene742	8.25e-216	690.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,4H9Z3@91061|Bacilli,27FFH@186828|Carnobacteriaceae	91061|Bacilli	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
MMS2_k127_4501142_2	935948.KE386495_gene1561	1.102e-22	105.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia,42GU3@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Lytic transglycosylase catalytic	yjbJ	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
MMS2_k127_4501142_1	935948.KE386495_gene1820	6.794e-29	123.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,42GEY@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM competence protein ComEA helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
MMS2_k127_4501142_4	1550091.JROE01000007_gene2840	4.045e-05	52.0	COG0658@1|root,COG0658@2|Bacteria,4NEJH@976|Bacteroidetes,1IQH4@117747|Sphingobacteriia	976|Bacteroidetes	S	TIGRFAM ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131
MMS2_k127_4504529_0	926692.AZYG01000040_gene1543	5.559e-34	133.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WA9Z@53433|Halanaerobiales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_4504529_2	1403819.BATR01000112_gene3748	2.049e-08	64.0	COG0500@1|root,COG0742@1|root,COG4122@1|root,COG0742@2|Bacteria,COG2226@2|Bacteria,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	ubiE1	-	-	ko:K15257,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000,ko03016	4.D.1.3	GT2,GT4	-	Cons_hypoth95,Methyltransf_11,SAM_MT
MMS2_k127_4509387_1	667014.Thein_1455	4.872e-05	46.0	COG0751@1|root,COG0751@2|Bacteria,2GH99@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
MMS2_k127_4509387_0	1444309.JAQG01000080_gene3984	4.046e-67	238.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,4H9NT@91061|Bacilli,26S3M@186822|Paenibacillaceae	91061|Bacilli	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
MMS2_k127_4521181_0	234267.Acid_7484	4.416e-65	225.0	COG0443@1|root,COG0443@2|Bacteria,3Y2XU@57723|Acidobacteria	57723|Acidobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS2_k127_4521181_2	986075.CathTA2_2226	1.712e-35	141.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMS2_k127_4521181_1	635013.TherJR_2453	1.245e-51	192.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,260NG@186807|Peptococcaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
MMS2_k127_4521181_3	945021.TEH_12970	0.0001499	45.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4HA60@91061|Bacilli,4AZGX@81852|Enterococcaceae	91061|Bacilli	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
MMS2_k127_4527334_0	635013.TherJR_1396	3.416e-74	256.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,2607V@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
MMS2_k127_4527334_1	246194.CHY_0290	7.944e-45	167.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,42GC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
MMS2_k127_4530513_0	1457250.BBMO01000002_gene2593	8.419e-20	102.0	arCOG00567@1|root,arCOG00567@2157|Archaea,2XVU1@28890|Euryarchaeota,23UZV@183963|Halobacteria	183963|Halobacteria	M	glycosyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS2_k127_4531392_0	631362.Thi970DRAFT_01232	1.75e-24	118.0	COG0639@1|root,COG0639@2|Bacteria,1R5DR@1224|Proteobacteria,1RS9W@1236|Gammaproteobacteria,1WXS1@135613|Chromatiales	135613|Chromatiales	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
MMS2_k127_455015_1	246194.CHY_0282	2.977e-83	281.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,42FAI@68295|Thermoanaerobacterales	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
MMS2_k127_455015_0	1379858.N508_00236	9.324e-151	482.0	COG0191@1|root,COG0191@2|Bacteria,2GETH@200930|Deferribacteres	200930|Deferribacteres	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
MMS2_k127_455015_2	443254.Marpi_1585	8.576e-59	217.0	COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
MMS2_k127_455824_0	644282.Deba_0697	6.476e-193	609.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,42M8V@68525|delta/epsilon subdivisions,2WJ7S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	NRDD
MMS2_k127_455824_1	401526.TcarDRAFT_1482	2.458e-48	183.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4H1VN@909932|Negativicutes	909932|Negativicutes	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	AMIN,NAGPA
MMS2_k127_4563309_1	1379698.RBG1_1C00001G1833	4.107e-143	462.0	COG1379@1|root,COG1379@2|Bacteria,2NNW8@2323|unclassified Bacteria	2|Bacteria	L	DNA helicase	yqxK	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4178,PHP_C,UvrD-helicase,UvrD_C
MMS2_k127_4563309_0	1292035.H476_0470	4.742e-148	476.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,25QE3@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
MMS2_k127_4563309_2	373903.Hore_12300	5.821e-32	127.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WA8Z@53433|Halanaerobiales	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMS2_k127_4576852_0	153721.MYP_1856	6.01e-135	442.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,4NFKH@976|Bacteroidetes,47JB7@768503|Cytophagia	976|Bacteroidetes	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
MMS2_k127_4584060_0	700598.Niako_5053	6.042e-31	136.0	COG4447@1|root,COG4447@2|Bacteria,4NRP7@976|Bacteroidetes,1IU78@117747|Sphingobacteriia	976|Bacteroidetes	UW	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
MMS2_k127_4584060_1	477974.Daud_1714	1.013e-26	117.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H
MMS2_k127_4584555_0	525919.Apre_1163	3.042e-44	162.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,22HG0@1570339|Peptoniphilaceae	186801|Clostridia	FG	Histidine triad domain protein	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMS2_k127_4584555_1	1449063.JMLS01000008_gene5160	4.969e-16	83.0	COG1404@1|root,COG2010@1|root,COG1404@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1,PSCyt2,PSD1,Peptidase_M43
MMS2_k127_4602309_4	1192034.CAP_7156	1.656e-25	109.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2YTUP@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS2_k127_4602309_2	926561.KB900617_gene1675	3.028e-72	256.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,3WAI5@53433|Halanaerobiales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
MMS2_k127_4602309_1	349161.Dred_0674	4.408e-104	351.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2619Y@186807|Peptococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
MMS2_k127_4602309_0	1094508.Tsac_1567	9.925e-110	369.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,42EZQ@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS2_k127_4602309_3	1123239.KB898623_gene955	1.79e-70	248.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,4H9TP@91061|Bacilli	91061|Bacilli	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
MMS2_k127_4629268_1	443144.GM21_0770	2.095e-20	102.0	COG1466@1|root,COG1466@2|Bacteria,1RHE9@1224|Proteobacteria,42SNR@68525|delta/epsilon subdivisions,2WP96@28221|Deltaproteobacteria,43TIV@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
MMS2_k127_4629268_0	289376.THEYE_A1109	2.464e-37	147.0	COG0491@1|root,COG0491@2|Bacteria,3J0VN@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_4631239_3	189425.PGRAT_13515	7.761e-38	153.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,4HART@91061|Bacilli,26RTF@186822|Paenibacillaceae	91061|Bacilli	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06010	Formyl_trans_C,Formyl_trans_N
MMS2_k127_4631239_1	671143.DAMO_0259	2.26e-77	268.0	COG1091@1|root,COG1091@2|Bacteria,2NPG4@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rfbD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
MMS2_k127_4631239_0	580331.Thit_0645	2.824e-123	404.0	COG0438@1|root,COG0438@2|Bacteria,1TQN3@1239|Firmicutes,24ARN@186801|Clostridia,42I34@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_4631239_2	237368.SCABRO_04012	1.302e-45	188.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,2J1U3@203682|Planctomycetes	203682|Planctomycetes	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
MMS2_k127_46327_0	555079.Toce_1130	5.954e-105	345.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMS2_k127_46327_1	247490.KSU1_B0484	1.651e-61	214.0	COG0822@1|root,COG0822@2|Bacteria,2J0AN@203682|Planctomycetes	203682|Planctomycetes	C	NifU-like N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU_N
MMS2_k127_46327_2	1408310.JHUW01000010_gene2427	5.539e-27	116.0	COG0701@1|root,COG2608@1|root,COG0701@2|Bacteria,COG2608@2|Bacteria,4NDUJ@976|Bacteroidetes,2FNF8@200643|Bacteroidia	976|Bacteroidetes	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1,HMA
MMS2_k127_4648873_0	1004785.AMBLS11_04860	1e-116	392.0	COG1232@1|root,COG2089@1|root,COG1232@2|Bacteria,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,464CM@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG2089 Sialic acid synthase	neuB	GO:0003674,GO:0003824,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016740,GO:0016765,GO:0044238,GO:0071704,GO:1901576	2.5.1.101,2.5.1.56	ko:K01654,ko:K18430	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R10304	RC00159	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2,NeuB,SAF
MMS2_k127_4648873_1	357808.RoseRS_4077	3.943e-86	290.0	COG1208@1|root,COG1208@2|Bacteria,2G65W@200795|Chloroflexi,374YB@32061|Chloroflexia	200795|Chloroflexi	M	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
MMS2_k127_4650634_2	1105031.HMPREF1141_1562	4.498e-07	53.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,36EM4@31979|Clostridiaceae	186801|Clostridia	C	Fe-S type, tartrate fumarate subfamily, beta	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
MMS2_k127_4650634_0	1121430.JMLG01000006_gene1701	7.269e-92	309.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,26044@186807|Peptococcaceae	186801|Clostridia	C	Fe-S type, tartrate fumarate subfamily, alpha	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
MMS2_k127_4650634_1	278963.ATWD01000001_gene4408	1.788e-10	62.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria,2JII1@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
MMS2_k127_4651166_2	1121440.AUMA01000002_gene2153	2.953e-17	87.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2MB6D@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
MMS2_k127_4651166_1	592015.HMPREF1705_01411	2.253e-30	127.0	COG0558@1|root,COG0558@2|Bacteria,3TASR@508458|Synergistetes	508458|Synergistetes	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
MMS2_k127_4651166_0	246194.CHY_1164	1.423e-38	148.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,42EU2@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
MMS2_k127_4673931_0	635013.TherJR_0070	1.2e-73	252.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,2612W@186807|Peptococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
MMS2_k127_4680720_2	1229172.JQFA01000002_gene2910	4.346e-05	49.0	COG0457@1|root,COG2214@1|root,COG0457@2|Bacteria,COG2214@2|Bacteria,1G5VG@1117|Cyanobacteria,1HEFG@1150|Oscillatoriales	1117|Cyanobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_11
MMS2_k127_4680720_0	309801.trd_A0816	5.525e-94	323.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G66B@200795|Chloroflexi,27XNK@189775|Thermomicrobia	189775|Thermomicrobia	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
MMS2_k127_4680720_1	1223410.KN050846_gene1352	6.764e-06	51.0	COG1572@1|root,COG1572@2|Bacteria,4NDY7@976|Bacteroidetes,1HYJD@117743|Flavobacteriia	976|Bacteroidetes	S	Peptidase family C25	porU	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C25
MMS2_k127_4691514_1	401526.TcarDRAFT_0103	2.162e-48	181.0	COG0763@1|root,COG0763@2|Bacteria,1TRP4@1239|Firmicutes,4H22C@909932|Negativicutes	909932|Negativicutes	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
MMS2_k127_4691514_0	1279019.ARQK01000060_gene2216	4.422e-117	387.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1WWP0@135613|Chromatiales	135613|Chromatiales	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
MMS2_k127_4691764_0	696281.Desru_1280	1.526e-97	323.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,260V1@186807|Peptococcaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMS2_k127_4691764_3	1207063.P24_12177	2.124e-18	87.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2JTEV@204441|Rhodospirillales	204441|Rhodospirillales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMS2_k127_4691764_1	521011.Mpal_1345	1.006e-69	248.0	COG0614@1|root,arCOG03561@1|root,arCOG03561@2157|Archaea,arCOG03611@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
MMS2_k127_4691764_4	1231190.NA8A_08674	4.254e-14	78.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,43KD9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
MMS2_k127_4691764_2	1303518.CCALI_02688	9.296e-31	123.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
MMS2_k127_4699980_0	1094508.Tsac_2009	6.18e-68	239.0	COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,42FKM@68295|Thermoanaerobacterales	186801|Clostridia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
MMS2_k127_4699980_2	1120985.AUMI01000017_gene2671	3.489e-13	76.0	COG2206@1|root,COG2206@2|Bacteria,1VEWH@1239|Firmicutes,4H5GI@909932|Negativicutes	909932|Negativicutes	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	HD
MMS2_k127_4699980_1	323261.Noc_1696	7.201e-35	135.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales	135613|Chromatiales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
MMS2_k127_4707535_5	401526.TcarDRAFT_1482	8.96e-12	76.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,4H1VN@909932|Negativicutes	909932|Negativicutes	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	AMIN,NAGPA
MMS2_k127_4707535_0	517417.Cpar_0307	1.698e-169	546.0	COG0733@1|root,COG0733@2|Bacteria	2|Bacteria	S	neurotransmitter:sodium symporter activity	metP	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
MMS2_k127_4707535_2	635013.TherJR_1590	5.986e-80	277.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,26081@186807|Peptococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
MMS2_k127_4707535_1	264732.Moth_0889	6.197e-144	466.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,42ERE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_4707535_3	926561.KB900619_gene2494	9.105e-79	270.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,3WBB0@53433|Halanaerobiales	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
MMS2_k127_4707535_4	1209989.TepiRe1_1817	1.621e-25	109.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,42ETH@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
MMS2_k127_4721747_0	518766.Rmar_0027	4.277e-88	297.0	COG0012@1|root,COG0012@2|Bacteria,4NF7N@976|Bacteroidetes,1FJ4H@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
MMS2_k127_4721747_1	497964.CfE428DRAFT_3901	3.569e-51	190.0	COG0210@1|root,COG0210@2|Bacteria,46S8H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
MMS2_k127_4738015_1	1069080.KB913028_gene38	1.451e-23	105.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,4H30N@909932|Negativicutes	909932|Negativicutes	K	Cell envelope-like function transcriptional attenuator common domain protein	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
MMS2_k127_4738015_2	370438.PTH_0837	6.285e-22	100.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,262EU@186807|Peptococcaceae	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
MMS2_k127_4738015_0	880073.Calab_2574	0.0	1205.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS2_k127_473861_1	56780.SYN_02219	3.291e-68	235.0	COG1143@1|root,COG1143@2|Bacteria,1QVAQ@1224|Proteobacteria,43BPX@68525|delta/epsilon subdivisions,2X715@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	hdrE	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
MMS2_k127_473861_0	56780.SYN_02220	2.163e-126	409.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MQGV@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Oxidoreductase NAD-binding domain	hyhG	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
MMS2_k127_4740079_3	1047013.AQSP01000139_gene2394	3.135e-08	55.0	COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	DUF3318,Peptidase_M48
MMS2_k127_4740079_2	762903.Pedsa_1287	2.027e-16	86.0	299ZF@1|root,2ZX13@2|Bacteria,4P90N@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4740079_1	391009.Tmel_1047	5.727e-71	252.0	COG0012@1|root,COG0012@2|Bacteria,2GC12@200918|Thermotogae	200918|Thermotogae	J	GTP-binding protein YchF	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
MMS2_k127_4740079_0	1121403.AUCV01000001_gene720	2.528e-85	291.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2WMFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
MMS2_k127_4741864_1	247490.KSU1_C1550	1.145e-30	123.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	ideR	-	-	ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
MMS2_k127_4741864_0	926569.ANT_26930	4.23e-137	451.0	COG0370@1|root,COG0370@2|Bacteria	2|Bacteria	P	ferrous iron transmembrane transporter activity	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
MMS2_k127_4749593_0	313606.M23134_00406	2.524e-05	56.0	COG2273@1|root,COG2931@1|root,COG2273@2|Bacteria,COG2931@2|Bacteria,4NR3S@976|Bacteroidetes,47RKF@768503|Cytophagia	976|Bacteroidetes	Q	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
MMS2_k127_4762249_0	1283299.AUKG01000001_gene2259	8.635e-12	67.0	COG2456@1|root,COG2456@2|Bacteria,2HR2A@201174|Actinobacteria,4CSX5@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2304
MMS2_k127_4762249_1	1304885.AUEY01000019_gene1142	7.676e-11	72.0	COG1807@1|root,COG1807@2|Bacteria,1MY0U@1224|Proteobacteria,42QGD@68525|delta/epsilon subdivisions,2WM6Q@28221|Deltaproteobacteria,2MJRD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS2_k127_4765608_3	1122981.AUME01000002_gene2255	1.752e-09	59.0	COG0319@1|root,COG0319@2|Bacteria,4NS93@976|Bacteroidetes,2FS5C@200643|Bacteroidia	976|Bacteroidetes	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	-	-	-	-	-	-	-	-	-	UPF0054
MMS2_k127_4765608_2	1321778.HMPREF1982_03988	8.967e-14	76.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,268VX@186813|unclassified Clostridiales	186801|Clostridia	IM	Prokaryotic diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
MMS2_k127_4765608_1	1449126.JQKL01000073_gene3045	9.842e-112	374.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,268U9@186813|unclassified Clostridiales	186801|Clostridia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
MMS2_k127_4765608_0	941824.TCEL_00148	6.761e-233	732.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
MMS2_k127_4770722_0	96561.Dole_0426	1.165e-54	202.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,sCache_3_2
MMS2_k127_4770722_1	1111732.AZOD01000026_gene666	3.211e-14	82.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1X5SE@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
MMS2_k127_4770890_2	555079.Toce_1364	2.506e-44	164.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,42F3U@68295|Thermoanaerobacterales	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
MMS2_k127_4770890_1	370438.PTH_0920	1.166e-47	179.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
MMS2_k127_4770890_0	304371.MCP_1345	4.091e-111	368.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0071704	2.7.1.15,2.7.1.213	ko:K00852,ko:K21057	ko00030,ko00240,map00030,map00240	-	R00513,R00964,R01051,R01666,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS2_k127_4778220_0	509191.AEDB02000028_gene2880	9.95e-63	224.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,3WG7J@541000|Ruminococcaceae	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
MMS2_k127_4778220_1	1407650.BAUB01000010_gene1962	2.042e-06	52.0	COG0767@1|root,COG0767@2|Bacteria,1FZVP@1117|Cyanobacteria,1GZ82@1129|Synechococcus	1117|Cyanobacteria	Q	Belongs to the MlaE permease family	ycf63	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
MMS2_k127_4778654_0	797302.Halru_2938	5.326e-55	201.0	COG0428@1|root,arCOG00576@2157|Archaea,2XXNC@28890|Euryarchaeota,23YW7@183963|Halobacteria	183963|Halobacteria	P	ZIP Zinc transporter	-	-	-	ko:K16267	-	-	-	-	ko00000,ko02000	2.A.5.4.11	-	-	Zip
MMS2_k127_4778654_1	498848.TaqDRAFT_4817	6.723e-26	109.0	COG0739@1|root,COG0739@2|Bacteria,1WIP1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS2_k127_4782951_0	1209989.TepiRe1_1479	9.436e-58	207.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,42EZT@68295|Thermoanaerobacterales	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18870	Orn_Arg_deC_N,Orn_DAP_Arg_deC
MMS2_k127_4782951_1	357808.RoseRS_2786	3.758e-39	151.0	COG1520@1|root,COG1520@2|Bacteria,2G9GE@200795|Chloroflexi,3774I@32061|Chloroflexia	32061|Chloroflexia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4798180_0	4565.Traes_6DS_CDB16CE3F.1	6.42e-154	496.0	COG0126@1|root,KOG1367@2759|Eukaryota,37R6T@33090|Viridiplantae,3GA5G@35493|Streptophyta,3KYXR@4447|Liliopsida,3I2UD@38820|Poales	35493|Streptophyta	G	Belongs to the phosphoglycerate kinase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS2_k127_4798180_1	1196028.ALEF01000043_gene424	1.226e-141	456.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli,4C4ZC@84406|Virgibacillus	91061|Bacilli	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
MMS2_k127_4803201_0	42256.RradSPS_1030	4.14e-26	113.0	COG1306@1|root,COG1306@2|Bacteria,2GNVR@201174|Actinobacteria	201174|Actinobacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
MMS2_k127_4804604_1	1347392.CCEZ01000044_gene602	8.732e-26	110.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,36I5W@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMS2_k127_4804604_0	1122216.AUHW01000005_gene455	3.252e-41	154.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,4H4X8@909932|Negativicutes	909932|Negativicutes	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
MMS2_k127_4804604_2	1173028.ANKO01000020_gene5442	3.855e-18	87.0	COG0085@1|root,COG0085@2|Bacteria,1G14Y@1117|Cyanobacteria,1H8TE@1150|Oscillatoriales	1117|Cyanobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS2_k127_483642_0	373903.Hore_15820	1.596e-33	139.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,3WAD6@53433|Halanaerobiales	186801|Clostridia	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS2_k127_4841115_0	237368.SCABRO_00273	4.666e-20	102.0	COG4972@1|root,COG4972@2|Bacteria,2IZC6@203682|Planctomycetes	203682|Planctomycetes	NU	pilus assembly protein	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
MMS2_k127_4856039_1	1120972.AUMH01000004_gene1385	3.127e-83	280.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,279A5@186823|Alicyclobacillaceae	91061|Bacilli	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK5	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_4856039_0	1499967.BAYZ01000079_gene883	1.596e-186	588.0	COG2873@1|root,COG2873@2|Bacteria,2NQN4@2323|unclassified Bacteria	2|Bacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
MMS2_k127_4857276_0	378806.STAUR_3426	5.179e-157	506.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2YTWM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K02474,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
MMS2_k127_4857276_1	397291.C804_03117	2.337e-10	62.0	COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia,27K6Q@186928|unclassified Lachnospiraceae	186801|Clostridia	M	NAD(P)H-binding	pseB	-	4.2.1.115	ko:K15894	ko00520,map00520	-	R09697	RC02609	ko00000,ko00001,ko01000	-	-	-	Polysacc_synt_2
MMS2_k127_4862316_2	373903.Hore_06810	1.781e-24	107.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,3WBJ4@53433|Halanaerobiales	186801|Clostridia	E	Peptidase family M20 M25 M40	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS2_k127_4862316_1	1123288.SOV_1c03400	8.516e-59	214.0	COG0611@1|root,COG0802@1|root,COG0611@2|Bacteria,COG0802@2|Bacteria,1V0SM@1239|Firmicutes,4H3FP@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_4862316_0	555088.DealDRAFT_0302	1.404e-133	433.0	COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,42JIU@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
MMS2_k127_4870799_2	582515.KR51_00032970	2.094e-08	66.0	COG0438@1|root,COG0438@2|Bacteria,1GF7V@1117|Cyanobacteria	1117|Cyanobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4870799_0	1471459.JFLJ01000134_gene1266	2.641e-67	246.0	COG0438@1|root,COG0438@2|Bacteria,1G99Z@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS2_k127_48750_0	635013.TherJR_2843	4.791e-53	206.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,262C0@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
MMS2_k127_4881829_2	891968.Anamo_0898	3.135e-21	95.0	COG0636@1|root,COG0636@2|Bacteria,3TAWT@508458|Synergistetes	508458|Synergistetes	C	PFAM H transporting two-sector ATPase C subunit	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS2_k127_4881829_3	1410668.JNKC01000006_gene625	9.878e-12	69.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,36JRX@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMS2_k127_4881829_0	555079.Toce_2042	2.121e-252	791.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS2_k127_4881829_1	562743.JH976435_gene3175	4.671e-40	151.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,4HBJN@91061|Bacilli	91061|Bacilli	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	ntpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_4888163_0	635013.TherJR_2548	1.327e-39	153.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,261RD@186807|Peptococcaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
MMS2_k127_4888163_2	1340493.JNIF01000003_gene4401	5.648e-06	56.0	2CB8T@1|root,349A2@2|Bacteria,3Y8JH@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase
MMS2_k127_4888163_1	177437.HRM2_21230	1.506e-35	145.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2MK0I@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS2_k127_4894479_1	697281.Mahau_0626	1.557e-09	60.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,42GA5@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM H transporting two-sector ATPase C subunit	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS2_k127_4894479_0	555088.DealDRAFT_1684	1.339e-92	328.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS2_k127_4901505_4	255470.cbdbA1527	1.549e-13	73.0	COG2251@1|root,COG2251@2|Bacteria,2GA6D@200795|Chloroflexi,34D4U@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
MMS2_k127_4901505_0	1499967.BAYZ01000065_gene6090	8.214e-93	314.0	COG0042@1|root,COG0042@2|Bacteria,2NP3E@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusA	GO:0000049,GO:0000166,GO:0002943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010181,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0032553,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363	-	ko:K05539,ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
MMS2_k127_4901505_3	304371.MCP_0131	1.07e-25	113.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota	28890|Euryarchaeota	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS2_k127_4901505_2	471875.RUMLAC_01358	6.073e-40	156.0	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,3WK2K@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
MMS2_k127_4901505_1	1045858.Bint_2494	2.884e-51	191.0	COG0841@1|root,COG0841@2|Bacteria,2J9MF@203691|Spirochaetes	203691|Spirochaetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
MMS2_k127_4902992_0	334390.LAF_1839	4.033e-95	323.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,4HA06@91061|Bacilli,3F3WA@33958|Lactobacillaceae	91061|Bacilli	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
MMS2_k127_4902992_1	373903.Hore_23570	2.974e-41	159.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WAPG@53433|Halanaerobiales	186801|Clostridia	S	single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
MMS2_k127_4907366_1	1200557.JHWV01000005_gene1535	6.955e-54	193.0	COG1127@1|root,COG1127@2|Bacteria,1UGV0@1239|Firmicutes,4H251@909932|Negativicutes	909932|Negativicutes	Q	ABC transporter, ATP-binding protein	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
MMS2_k127_4907366_0	197221.22295170	1.563e-57	205.0	COG0767@1|root,COG0767@2|Bacteria,1FZVP@1117|Cyanobacteria	1117|Cyanobacteria	Q	Belongs to the MlaE permease family	ycf63	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
MMS2_k127_492209_0	1280698.AUJS01000009_gene731	1.446e-16	92.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,27UXF@189330|Dorea	186801|Clostridia	K	COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
MMS2_k127_492209_1	1001585.MDS_0283	1.032e-15	83.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RYEF@1236|Gammaproteobacteria,1YKPF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	PAS fold	bphP	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_2,PHY,Response_reg
MMS2_k127_4947361_0	682795.AciX8_3506	9.864e-51	195.0	COG3934@1|root,COG3934@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_4_9,Cellulase,Glyco_hydro_2_C,Glyco_hydro_42,Glycos_transf_2
MMS2_k127_4953613_2	635013.TherJR_2819	1.497e-52	191.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,260T2@186807|Peptococcaceae	186801|Clostridia	G	alpha beta alpha domain I	pgm	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS2_k127_4953613_1	1209989.TepiRe1_1589	7.89e-57	203.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,42G0W@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family. PyrR subfamily	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
MMS2_k127_4953613_0	671143.DAMO_2896	1.416e-135	444.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2NNZG@2323|unclassified Bacteria	2|Bacteria	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS2_k127_4955674_2	388739.RSK20926_01062	6.761e-44	172.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2P1Q8@2433|Roseobacter	28211|Alphaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
MMS2_k127_4955674_0	436308.Nmar_0140	4.623e-133	432.0	COG0119@1|root,arCOG02092@2157|Archaea	2157|Archaea	H	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	4.1.3.39,4.1.3.4	ko:K01640,ko:K01666	ko00072,ko00280,ko00281,ko00360,ko00362,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,ko04146,map00072,map00280,map00281,map00360,map00362,map00621,map00622,map00650,map01100,map01120,map01220,map04146	M00036,M00088,M00545,M00569	R00750,R01360,R08090	RC00307,RC00371,RC00502,RC00503,RC01118,RC01946	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
MMS2_k127_4955674_1	866895.HBHAL_1984	2.664e-71	245.0	COG0584@1|root,COG0584@2|Bacteria,1VQSU@1239|Firmicutes	1239|Firmicutes	C	glycerophosphoryl diester phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4963965_0	62977.ACIAD3068	6.11e-19	99.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,3NJ4S@468|Moraxellaceae	1236|Gammaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_2673	ACT_4,HD_4,RelA_SpoT,TGS
MMS2_k127_4982736_0	484770.UFO1_2967	8.015e-219	688.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,4H21Q@909932|Negativicutes	909932|Negativicutes	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
MMS2_k127_4982736_1	537013.CLOSTMETH_02472	2.638e-96	323.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,3WGRB@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the FtsK SpoIIIE SftA family	spoIIIE	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
MMS2_k127_4986063_4	555079.Toce_2177	6.152e-49	183.0	COG0616@1|root,COG0616@2|Bacteria,1TRQW@1239|Firmicutes,24BP1@186801|Clostridia,42G2U@68295|Thermoanaerobacterales	186801|Clostridia	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMS2_k127_4986063_1	1380408.AVGH01000039_gene2255	4.675e-77	269.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H9U2@91061|Bacilli,21VDC@150247|Anoxybacillus	91061|Bacilli	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
MMS2_k127_4986063_3	696281.Desru_2228	4.622e-58	208.0	COG0535@1|root,COG0535@2|Bacteria,1V3MC@1239|Firmicutes,24I1P@186801|Clostridia,262UK@186807|Peptococcaceae	186801|Clostridia	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_4986063_2	1131269.AQVV01000013_gene1726	1.073e-73	267.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS2_k127_4986063_0	635013.TherJR_0872	1.099e-173	557.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
MMS2_k127_4987897_1	1210884.HG799463_gene9298	5.94e-10	66.0	COG0657@1|root,COG1506@1|root,COG0657@2|Bacteria,COG1506@2|Bacteria,2IWRZ@203682|Planctomycetes	203682|Planctomycetes	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,COesterase
MMS2_k127_4987897_0	406552.NJ7G_0794	3.77e-62	226.0	COG0534@1|root,arCOG01731@2157|Archaea,2XU54@28890|Euryarchaeota,23SKQ@183963|Halobacteria	183963|Halobacteria	V	COG0534 Na -driven multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	MatE
MMS2_k127_498902_0	290315.Clim_2335	9.07e-41	159.0	COG0204@1|root,COG0204@2|Bacteria,1FDPA@1090|Chlorobi	1090|Chlorobi	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
MMS2_k127_4989987_1	1123376.AUIU01000013_gene1733	4.166e-78	267.0	COG0438@1|root,COG0438@2|Bacteria,3J0Z0@40117|Nitrospirae	40117|Nitrospirae	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
MMS2_k127_4989987_3	247490.KSU1_D0579	2.644e-41	165.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gtf2	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4989987_2	1379698.RBG1_1C00001G0656	1.219e-49	186.0	COG1877@1|root,COG1877@2|Bacteria,2NPXY@2323|unclassified Bacteria	2|Bacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0046872,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K01087,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	iE2348C_1286.E2348C_2018,iECED1_1282.ECED1_2163,iECIAI39_1322.ECIAI39_1155,iECS88_1305.ECS88_1952,iLF82_1304.LF82_1582,iNRG857_1313.NRG857_09495	Glyco_hydro_15,Glyco_transf_20,Trehalose_PPase
MMS2_k127_4989987_0	247490.KSU1_D0589	2.84e-83	285.0	COG0380@1|root,COG0380@2|Bacteria,2IYNH@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyltransferase family 20	-	-	2.4.1.15,3.1.3.12	ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
MMS2_k127_4991159_1	716544.wcw_1527	2.294e-14	73.0	COG0173@1|root,COG0173@2|Bacteria,2JFKW@204428|Chlamydiae	204428|Chlamydiae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
MMS2_k127_4991159_0	574087.Acear_0722	2.566e-139	454.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3WA8K@53433|Halanaerobiales	186801|Clostridia	J	tRNA synthetase class II core domain (G, H, P, S and T)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMS2_k127_4992438_1	1121289.JHVL01000030_gene421	5.327e-73	252.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,36ESG@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
MMS2_k127_4992438_0	706587.Desti_3602	1.925e-75	259.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
MMS2_k127_4995103_0	1128427.KB904821_gene1227	1.026e-57	207.0	COG1573@1|root,COG1573@2|Bacteria,1FZYH@1117|Cyanobacteria,1H840@1150|Oscillatoriales	1117|Cyanobacteria	L	Uracil-DNA glycosylase, family 4	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS2_k127_4995103_1	1094508.Tsac_1822	3.109e-45	170.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,42FB8@68295|Thermoanaerobacterales	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
MMS2_k127_4995138_0	243231.GSU0686	2.121e-145	472.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
MMS2_k127_5003592_0	477974.Daud_0295	3.611e-71	252.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,260I5@186807|Peptococcaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
MMS2_k127_5009084_1	656519.Halsa_1331	8.867e-15	78.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,3WAGQ@53433|Halanaerobiales	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
MMS2_k127_5009084_0	572479.Hprae_0958	5.293e-41	159.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,3WA82@53433|Halanaerobiales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
MMS2_k127_5015900_1	1175306.GWL_33550	5.157e-11	68.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,474HZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
MMS2_k127_5015900_0	1123372.AUIT01000008_gene608	1.054e-115	378.0	COG0653@1|root,COG0653@2|Bacteria,2GGR1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
MMS2_k127_5016111_0	491915.Aflv_0748	2.728e-62	228.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4HAUV@91061|Bacilli,21W1B@150247|Anoxybacillus	91061|Bacilli	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
MMS2_k127_5016111_1	86416.Clopa_2409	1.502e-37	145.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,36IV4@31979|Clostridiaceae	186801|Clostridia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
MMS2_k127_5016111_2	1122609.AUGT01000002_gene3974	6.057e-06	49.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4DP1M@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
MMS2_k127_505357_3	96561.Dole_2433	1.188e-10	67.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42TFM@68525|delta/epsilon subdivisions,2WPBE@28221|Deltaproteobacteria,2MK7R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS2_k127_505357_0	237368.SCABRO_02716	3.313e-59	213.0	COG1208@1|root,COG1208@2|Bacteria,2J0B4@203682|Planctomycetes	203682|Planctomycetes	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
MMS2_k127_505357_4	1304284.L21TH_2383	0.0004646	47.0	COG1943@1|root,COG1943@2|Bacteria,1VAIQ@1239|Firmicutes,25CMR@186801|Clostridia,36WY2@31979|Clostridiaceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
MMS2_k127_505357_1	237368.SCABRO_02713	1.658e-45	171.0	COG0279@1|root,COG0279@2|Bacteria,2IZ19@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoheptose isomerase	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
MMS2_k127_505357_2	592027.CLG_B1268	6.351e-22	106.0	COG2244@1|root,COG2244@2|Bacteria,1TP7R@1239|Firmicutes,24AD0@186801|Clostridia,36EMQ@31979|Clostridiaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
MMS2_k127_50584_0	1047013.AQSP01000105_gene1454	3.995e-107	353.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS2_k127_50584_1	1047013.AQSP01000105_gene1453	1.574e-81	278.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	fixB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	iAF987.Gmet_2066,iAF987.Gmet_2257	ETF,ETF_alpha,Fer4
MMS2_k127_511404_2	309799.DICTH_1465	2.538e-28	115.0	COG0540@1|root,COG0540@2|Bacteria	2|Bacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
MMS2_k127_511404_0	373903.Hore_07370	1.398e-57	206.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,3WAMH@53433|Halanaerobiales	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
MMS2_k127_511404_1	515635.Dtur_1532	3.387e-52	190.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
MMS2_k127_514499_1	273068.TTE0899	2.491e-14	80.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,42GQR@68295|Thermoanaerobacterales	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
MMS2_k127_514499_0	572479.Hprae_1235	8.086e-142	457.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WAHE@53433|Halanaerobiales	186801|Clostridia	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
MMS2_k127_514499_2	1519439.JPJG01000037_gene943	1.18e-08	59.0	COG3087@1|root,COG3087@2|Bacteria,1UPFP@1239|Firmicutes,25HFN@186801|Clostridia	186801|Clostridia	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
MMS2_k127_526227_1	661478.OP10G_2092	0.0001969	49.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PKD,PSII_BNR,Sortilin-Vps10
MMS2_k127_526227_0	880073.Calab_3215	4.08e-06	59.0	COG0366@1|root,COG0708@1|root,COG0366@2|Bacteria,COG0708@2|Bacteria,2NREA@2323|unclassified Bacteria	2|Bacteria	G	Glycosyl hydrolase family 70	-	-	3.1.11.2,3.2.1.1	ko:K01142,ko:K01176	ko00500,ko01100,ko03410,ko04973,map00500,map01100,map03410,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000,ko03400	-	GH13	-	Alpha-amylase,CBM_25,DUF1939,He_PIG
MMS2_k127_547208_0	857293.CAAU_0436	2.829e-50	185.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_553296_2	1379698.RBG1_1C00001G0128	3.333e-24	103.0	COG1606@1|root,COG1606@2|Bacteria,2NP5T@2323|unclassified Bacteria	2|Bacteria	L	tRNA processing	larE	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
MMS2_k127_553296_1	484770.UFO1_1921	1.009e-38	149.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,4H4CN@909932|Negativicutes	909932|Negativicutes	K	Transcriptional regulator	iscR2	-	-	-	-	-	-	-	-	-	-	-	Rrf2
MMS2_k127_553296_0	401526.TcarDRAFT_0036	7.7e-67	232.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,4H31K@909932|Negativicutes	909932|Negativicutes	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
MMS2_k127_571288_2	272562.CA_C2173	6.623e-13	70.0	COG1215@1|root,COG1215@2|Bacteria,1UIBE@1239|Firmicutes,25EGF@186801|Clostridia,36UPW@31979|Clostridiaceae	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_571288_1	877455.Metbo_0856	1.604e-26	120.0	COG0463@1|root,arCOG01385@2157|Archaea	2157|Archaea	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
MMS2_k127_571288_0	485916.Dtox_2855	2.146e-91	306.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,261N7@186807|Peptococcaceae	186801|Clostridia	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_587048_1	1123405.AUMM01000005_gene881	5.878e-16	83.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,4H9Q8@91061|Bacilli,26NKI@186821|Sporolactobacillaceae	91061|Bacilli	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
MMS2_k127_587048_0	653733.Selin_0529	1.062e-90	302.0	COG0740@1|root,COG0740@2|Bacteria	2|Bacteria	OU	serine-type endopeptidase activity	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
MMS2_k127_587048_2	247633.GP2143_06410	2.197e-12	68.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1J4ZW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
MMS2_k127_605181_0	289376.THEYE_A1277	3.532e-123	402.0	COG0119@1|root,COG0119@2|Bacteria,3J0F7@40117|Nitrospirae	40117|Nitrospirae	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
MMS2_k127_605181_1	762903.Pedsa_1346	8.812e-13	69.0	COG0041@1|root,COG0041@2|Bacteria,4NME9@976|Bacteroidetes,1IRVT@117747|Sphingobacteriia	976|Bacteroidetes	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMS2_k127_610983_2	335541.Swol_1169	1.961e-86	298.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,42JYE@68298|Syntrophomonadaceae	186801|Clostridia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin,Trypsin_2
MMS2_k127_610983_0	747365.Thena_1292	3.449e-144	466.0	COG0516@1|root,COG0516@2|Bacteria,1VS73@1239|Firmicutes,24YU0@186801|Clostridia	186801|Clostridia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
MMS2_k127_610983_3	272630.MexAM1_META1p1357	6.614e-09	59.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2UBXX@28211|Alphaproteobacteria,1JVC9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02113,ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
MMS2_k127_610983_1	574087.Acear_2216	7.56e-131	421.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,3WADA@53433|Halanaerobiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_618724_2	529884.Rhola_00012150	1.899e-45	167.0	COG0100@1|root,COG0100@2|Bacteria,2IFFC@201174|Actinobacteria,4FNCF@85023|Microbacteriaceae	201174|Actinobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS2_k127_618724_3	373903.Hore_01420	1.377e-37	144.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,3WAR3@53433|Halanaerobiales	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMS2_k127_618724_5	869210.Marky_1702	1.536e-15	76.0	COG0257@1|root,COG0257@2|Bacteria,1WKSI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
MMS2_k127_618724_4	1347086.CCBA010000014_gene681	2.139e-30	121.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
MMS2_k127_618724_0	644282.Deba_2916	4.365e-80	274.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS2_k127_618724_1	572546.Arcpr_1334	2.563e-52	188.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,246UX@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
MMS2_k127_622091_1	1121324.CLIT_23c00940	1.838e-44	168.0	COG0127@1|root,COG0689@1|root,COG0127@2|Bacteria,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,25QCQ@186804|Peptostreptococcaceae	186801|Clostridia	F	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
MMS2_k127_622091_0	1504319.GM45_3420	4.433e-58	207.0	COG5310@1|root,COG5310@2|Bacteria,2IRSZ@201174|Actinobacteria	201174|Actinobacteria	Q	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
MMS2_k127_62857_0	644282.Deba_1148	4.405e-145	467.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS2_k127_62857_2	243274.THEMA_02710	1.847e-48	177.0	COG0347@1|root,COG0347@2|Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
MMS2_k127_62857_1	1121438.JNJA01000007_gene1758	7.314e-74	252.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS2_k127_676418_0	1089553.Tph_c26500	7.663e-171	545.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_688375_1	880073.Calab_1613	2.181e-22	101.0	COG0509@1|root,COG2204@1|root,COG0509@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GAF_2,GCV_H,Response_reg
MMS2_k127_688375_0	552811.Dehly_0133	7.622e-115	376.0	COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi,34D8K@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
MMS2_k127_699762_0	1173024.KI912153_gene84	2.859e-09	69.0	COG2911@1|root,COG2911@2|Bacteria,1G1RU@1117|Cyanobacteria,1JH3A@1189|Stigonemataceae	1117|Cyanobacteria	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	DUF748,TamB
MMS2_k127_718701_0	926561.KB900623_gene858	3.265e-97	330.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,3WAP5@53433|Halanaerobiales	186801|Clostridia	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
MMS2_k127_718701_1	574087.Acear_1757	5.453e-40	154.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,3WBXP@53433|Halanaerobiales	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI
MMS2_k127_718701_2	399550.Smar_1381	4.471e-26	110.0	COG0413@1|root,arCOG00584@2157|Archaea,2XPQ2@28889|Crenarchaeota	28889|Crenarchaeota	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
MMS2_k127_732836_0	316057.RPD_1872	4.594e-34	144.0	COG0784@1|root,COG3852@1|root,COG0784@2|Bacteria,COG3852@2|Bacteria,1NC9X@1224|Proteobacteria,2TXEG@28211|Alphaproteobacteria,3K6TV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
MMS2_k127_732836_1	436114.SYO3AOP1_0675	6.263e-08	54.0	COG0621@1|root,COG0621@2|Bacteria,2G3M4@200783|Aquificae	200783|Aquificae	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
MMS2_k127_738475_1	1301100.HG529419_gene3066	1.357e-73	253.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
MMS2_k127_738475_0	927704.SELR_25790	6.738e-79	269.0	COG0381@1|root,COG0381@2|Bacteria,1TQZT@1239|Firmicutes,4H2UD@909932|Negativicutes	909932|Negativicutes	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	mnaA	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
MMS2_k127_740517_2	264732.Moth_1560	1.983e-42	159.0	COG2231@1|root,COG2231@2|Bacteria,1V4SG@1239|Firmicutes,24G98@186801|Clostridia,42G1N@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM HhH-GPD family protein	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
MMS2_k127_740517_0	237368.SCABRO_00990	7.359e-73	253.0	COG0134@1|root,COG0134@2|Bacteria,2IX3M@203682|Planctomycetes	203682|Planctomycetes	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
MMS2_k127_740517_1	521011.Mpal_0423	7.638e-48	184.0	COG3391@1|root,arCOG02516@1|root,arCOG02516@2157|Archaea,arCOG03563@2157|Archaea,2Y7Y4@28890|Euryarchaeota,2NBN4@224756|Methanomicrobia	2157|Archaea	S	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,HemolysinCabind,Kelch_4,NHL,PKD
MMS2_k127_740517_3	56780.SYN_01364	4.617e-31	137.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
MMS2_k127_743991_0	649747.HMPREF0083_02687	8.157e-154	493.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26QJA@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
MMS2_k127_745356_0	370438.PTH_1959	1.068e-40	158.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,261QF@186807|Peptococcaceae	186801|Clostridia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM	cbiM2	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
MMS2_k127_745356_1	909663.KI867150_gene302	2.083e-07	62.0	COG2067@1|root,COG2067@2|Bacteria,1N1F4@1224|Proteobacteria,42ZP2@68525|delta/epsilon subdivisions,2WUUM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
MMS2_k127_749193_1	237368.SCABRO_01097	8.855e-10	65.0	COG2165@1|root,COG2165@2|Bacteria,2J0S3@203682|Planctomycetes	203682|Planctomycetes	U	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
MMS2_k127_749193_0	1123405.AUMM01000003_gene600	3.025e-31	129.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HUAW@91061|Bacilli	91061|Bacilli	E	ABC transporter, substratebinding protein	XK27_07260	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_764786_0	945713.IALB_1259	3.73e-10	74.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_77038_0	635013.TherJR_1020	1.596e-05	57.0	COG0457@1|root,COG0457@2|Bacteria	635013.TherJR_1020|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_780769_2	555079.Toce_0108	0.0002794	47.0	COG2919@1|root,COG2919@2|Bacteria,1VGDD@1239|Firmicutes,25JJJ@186801|Clostridia,42HFW@68295|Thermoanaerobacterales	186801|Clostridia	D	Septum formation initiator	-	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
MMS2_k127_780769_1	309799.DICTH_0884	1.097e-60	218.0	COG1989@1|root,COG1989@2|Bacteria	2|Bacteria	NOU	aspartic-type endopeptidase activity	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
MMS2_k127_780769_0	580331.Thit_1057	6.11e-95	320.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,42F4T@68295|Thermoanaerobacterales	186801|Clostridia	NU	PFAM Type II secretion system protein E	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
MMS2_k127_790175_2	290317.Cpha266_1194	1.103e-15	79.0	COG1554@1|root,COG1554@2|Bacteria,1FED6@1090|Chlorobi	1090|Chlorobi	G	glycoside hydrolase, family 65 domain protein	-	-	2.4.1.230	ko:K10231	-	-	-	-	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
MMS2_k127_790175_1	608506.COB47_0355	4.576e-57	206.0	COG0637@1|root,COG0637@2|Bacteria,1VA5Z@1239|Firmicutes,24JNY@186801|Clostridia,42J1H@68295|Thermoanaerobacterales	186801|Clostridia	S	HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS2_k127_790175_0	246194.CHY_0668	5.298e-115	383.0	COG0438@1|root,COG0438@2|Bacteria,1V2NV@1239|Firmicutes,25ERN@186801|Clostridia,42HMK@68295|Thermoanaerobacterales	186801|Clostridia	M	Glycosyl transferase 4-like domain	-	-	2.4.1.348	ko:K06338,ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_796341_0	696369.KI912183_gene1429	4.551e-130	428.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,260PT@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS2_k127_796341_1	1449126.JQKL01000006_gene799	4.854e-112	375.0	COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,267YS@186813|unclassified Clostridiales	186801|Clostridia	S	Helix-hairpin-helix DNA-binding motif class 1	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Radical_SAM
MMS2_k127_800430_1	935948.KE386494_gene695	1.559e-67	244.0	COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,42FYE@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Glycoside hydrolase family 42 domain protein	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
MMS2_k127_800430_0	1267535.KB906767_gene2550	1.047e-218	694.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMS2_k127_800430_2	858215.Thexy_2216	8.689e-44	164.0	COG2182@1|root,COG2182@2|Bacteria,1UI3N@1239|Firmicutes,25ERM@186801|Clostridia,42G0P@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Bacterial extracellular solute-binding, family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
MMS2_k127_80324_0	747365.Thena_0401	1.411e-172	546.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia	186801|Clostridia	M	epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_80324_1	565034.BHWA1_01691	3.656e-53	192.0	COG1215@1|root,COG1215@2|Bacteria,2JA3U@203691|Spirochaetes	203691|Spirochaetes	H	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_803870_4	429009.Adeg_1520	3.706e-35	137.0	COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,42GJK@68295|Thermoanaerobacterales	186801|Clostridia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMS2_k127_803870_6	1304284.L21TH_0897	1.721e-26	112.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,36JMN@31979|Clostridiaceae	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMS2_k127_803870_0	588581.Cpap_1362	1.37e-72	251.0	COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,3WGIF@541000|Ruminococcaceae	186801|Clostridia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMS2_k127_803870_3	1173028.ANKO01000204_gene4710	1.505e-40	154.0	COG0197@1|root,COG0197@2|Bacteria,1G55B@1117|Cyanobacteria,1HARZ@1150|Oscillatoriales	1117|Cyanobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS2_k127_803870_8	1379698.RBG1_1C00001G1588	0.0001414	46.0	COG0255@1|root,COG0255@2|Bacteria,2NQ49@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal L29 protein	rpmC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMS2_k127_803870_7	335541.Swol_2324	1.5e-24	106.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMS2_k127_803870_1	401526.TcarDRAFT_1008	1.031e-49	180.0	COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,4H4B6@909932|Negativicutes	909932|Negativicutes	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMS2_k127_803870_5	443254.Marpi_0869	1.689e-27	116.0	COG0198@1|root,COG0198@2|Bacteria,2GD31@200918|Thermotogae	200918|Thermotogae	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
MMS2_k127_803870_2	370438.PTH_0332	5.843e-41	154.0	COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,2603I@186807|Peptococcaceae	186801|Clostridia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMS2_k127_804531_0	289376.THEYE_A0567	2.135e-153	491.0	COG1960@1|root,COG1960@2|Bacteria,3J13U@40117|Nitrospirae	40117|Nitrospirae	C	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_804531_1	555079.Toce_1053	6.203e-113	373.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
MMS2_k127_804531_2	1121468.AUBR01000030_gene1220	6.731e-102	340.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,42F74@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
MMS2_k127_804531_3	401053.AciPR4_0322	6.282e-12	67.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
MMS2_k127_804531_4	608538.HTH_0321	6.289e-05	46.0	COG1399@1|root,COG1399@2|Bacteria,2G4DV@200783|Aquificae	200783|Aquificae	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
MMS2_k127_804721_0	926561.KB900618_gene96	1.475e-146	484.0	COG0823@1|root,COG0823@2|Bacteria,1UTUZ@1239|Firmicutes,254F5@186801|Clostridia,3WBZM@53433|Halanaerobiales	186801|Clostridia	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_809753_2	1128398.Curi_c27240	1.14e-05	52.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia,26BUH@186813|unclassified Clostridiales	186801|Clostridia	CO	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
MMS2_k127_809753_1	1278309.KB907104_gene942	1.524e-22	108.0	COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria,1XHST@135619|Oceanospirillales	135619|Oceanospirillales	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
MMS2_k127_809753_0	1121468.AUBR01000032_gene1192	2.981e-104	349.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,42EKM@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS2_k127_809753_3	402881.Plav_0194	1.253e-05	56.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,1JP63@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	OstA-like protein	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
MMS2_k127_809753_4	1122947.FR7_1576	0.0009532	50.0	COG3117@1|root,COG3117@2|Bacteria,1V9U6@1239|Firmicutes,4H4TV@909932|Negativicutes	909932|Negativicutes	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	-	-	-	-	-	-	-	-	-	LptC
MMS2_k127_825342_2	123214.PERMA_0717	0.0003108	48.0	COG1766@1|root,COG1766@2|Bacteria,2G3NR@200783|Aquificae	200783|Aquificae	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
MMS2_k127_825342_1	635013.TherJR_1540	1.535e-25	115.0	COG1317@1|root,COG1317@2|Bacteria,1VEUV@1239|Firmicutes,24QUG@186801|Clostridia,262Y4@186807|Peptococcaceae	186801|Clostridia	N	PFAM Flagellar assembly protein FliH Type III secretion system HrpE	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
MMS2_k127_825342_0	401526.TcarDRAFT_2138	8.25e-116	379.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,4H2V3@909932|Negativicutes	909932|Negativicutes	N	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412	ko02040,map02040	-	-	-	ko00000,ko00001,ko01000,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_829362_0	767817.Desgi_3422	6.245e-114	374.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,248Z9@186801|Clostridia	186801|Clostridia	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS2_k127_829362_1	767817.Desgi_3423	6.822e-77	265.0	COG0451@1|root,COG0451@2|Bacteria,1UZR1@1239|Firmicutes,24DWP@186801|Clostridia	186801|Clostridia	GM	NAD dependent epimerase dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_85342_0	1291050.JAGE01000001_gene2598	5.069e-15	82.0	COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia,3WINI@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
MMS2_k127_85342_1	1123376.AUIU01000014_gene573	1.66e-05	52.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argH	GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K00619,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0946	ASL_C2,Acetyltransf_1,Lyase_1
MMS2_k127_859743_4	574087.Acear_0538	2.249e-37	146.0	COG2768@1|root,COG2878@1|root,COG2768@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,3WAH7@53433|Halanaerobiales	186801|Clostridia	C	TIGRFAM electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
MMS2_k127_859743_0	945713.IALB_0249	6.413e-83	278.0	COG4657@1|root,COG4657@2|Bacteria	2|Bacteria	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
MMS2_k127_859743_2	945713.IALB_0250	4.144e-66	231.0	COG4660@1|root,COG4660@2|Bacteria	2|Bacteria	C	electron transport chain	rnfE	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	2.3.1.243,4.2.99.18	ko:K02560,ko:K03613,ko:K10773	ko00540,ko01100,ko03410,map00540,map01100,map03410	M00060	R05075	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko03400	-	-	-	Rnf-Nqr
MMS2_k127_859743_3	945713.IALB_0251	8.752e-39	151.0	COG4659@1|root,COG4659@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
MMS2_k127_859743_1	555079.Toce_0699	1.147e-82	280.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,42FR3@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
MMS2_k127_867218_0	644966.Tmar_0462	2.223e-70	246.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS2_k127_868231_1	1123239.KB898635_gene2814	7.019e-47	173.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli	91061|Bacilli	L	Hydrolase, tatd	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
MMS2_k127_868231_0	523845.AQXV01000055_gene144	3.024e-63	222.0	COG1898@1|root,arCOG04188@2157|Archaea,2XVIP@28890|Euryarchaeota,23RBN@183939|Methanococci	183939|Methanococci	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
MMS2_k127_868231_2	330214.NIDE0851	1.961e-27	116.0	COG0785@1|root,COG0785@2|Bacteria,3J0KU@40117|Nitrospirae	40117|Nitrospirae	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
MMS2_k127_873763_0	1120973.AQXL01000114_gene713	2.135e-96	327.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,2783E@186823|Alicyclobacillaceae	91061|Bacilli	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS2_k127_889701_1	289376.THEYE_A0589	3.354e-44	176.0	COG0671@1|root,COG1807@1|root,COG0671@2|Bacteria,COG1807@2|Bacteria,3J155@40117|Nitrospirae	40117|Nitrospirae	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,PMT_2
MMS2_k127_889701_0	945713.IALB_1713	1.103e-45	178.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
MMS2_k127_893312_2	1120945.ATUW01000003_gene235	0.0001145	48.0	COG3311@1|root,COG3311@2|Bacteria,2GQGV@201174|Actinobacteria,4D6EG@85005|Actinomycetales	201174|Actinobacteria	K	DNA binding domain, excisionase family	xis	-	-	-	-	-	-	-	-	-	-	-	HTH_17
MMS2_k127_893312_1	1451261.AS96_09220	5.891e-19	92.0	COG3654@1|root,COG3654@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
MMS2_k127_893312_0	1183438.GKIL_2785	7.057e-172	553.0	COG0542@1|root,COG0542@2|Bacteria,1G0ZH@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
MMS2_k127_89621_1	402777.KB235904_gene4650	1.146e-25	109.0	COG2852@1|root,COG2852@2|Bacteria,1G6T3@1117|Cyanobacteria,1HBZY@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
MMS2_k127_89621_0	1276756.AUEX01000011_gene1308	2.264e-28	123.0	COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria,2VMK4@28216|Betaproteobacteria,4AJD4@80864|Comamonadaceae	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMS2_k127_897982_1	272134.KB731324_gene1502	5.747e-06	59.0	COG2866@1|root,COG2866@2|Bacteria,1GD2N@1117|Cyanobacteria	1117|Cyanobacteria	E	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
MMS2_k127_897982_0	562970.Btus_1884	5.493e-21	106.0	COG5184@1|root,COG5184@2|Bacteria,1UM5S@1239|Firmicutes,4ITQP@91061|Bacilli,279WZ@186823|Alicyclobacillaceae	91061|Bacilli	DMZ	Cadherin-like beta sandwich domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,SLH
MMS2_k127_904775_3	591001.Acfer_1301	1.867e-17	84.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,4H1VH@909932|Negativicutes	909932|Negativicutes	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M
MMS2_k127_904775_2	1121423.JONT01000001_gene2062	4.398e-64	230.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,261EW@186807|Peptococcaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
MMS2_k127_904775_1	370438.PTH_2750	2.181e-111	366.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS2_k127_904775_0	269799.Gmet_0552	3.196e-122	399.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,42Q04@68525|delta/epsilon subdivisions,2WKF7@28221|Deltaproteobacteria,43S5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Transketolase, pyrimidine binding domain	tklB	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS2_k127_904775_4	868595.Desca_2641	1.617e-16	80.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae	186801|Clostridia	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMS2_k127_908027_0	290315.Clim_2480	8.327e-69	245.0	COG1899@1|root,COG1899@2|Bacteria,1FDI8@1090|Chlorobi	1090|Chlorobi	H	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS2_k127_908027_1	1082705.JIBP01000023_gene3110	4.28e-16	80.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO0058,iYL1228.KPN_03963	Epimerase
MMS2_k127_909053_0	323259.Mhun_2688	1.742e-17	90.0	COG0642@1|root,arCOG02329@1|root,arCOG02352@1|root,arCOG02329@2157|Archaea,arCOG02351@2157|Archaea,arCOG02352@2157|Archaea,2Y7MY@28890|Euryarchaeota,2NAHA@224756|Methanomicrobia	224756|Methanomicrobia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_2,PAS_3,PAS_9,PocR
MMS2_k127_917549_0	1382359.JIAL01000001_gene1802	1.232e-133	433.0	COG0519@1|root,COG0519@2|Bacteria,3Y3VV@57723|Acidobacteria,2JHRV@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
MMS2_k127_934823_2	56780.SYN_02223	2.502e-32	131.0	COG0680@1|root,COG0680@2|Bacteria,1R3V7@1224|Proteobacteria	1224|Proteobacteria	C	maturation protease	hycI	GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.23.51	ko:K08315	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
MMS2_k127_934823_0	56780.SYN_02222	1.677e-207	652.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42RHV@68525|delta/epsilon subdivisions,2WNH5@28221|Deltaproteobacteria,2MSJH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyhL	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
MMS2_k127_934823_1	289376.THEYE_A1853	2.699e-35	136.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
MMS2_k127_956735_0	1262914.BN533_01902	8.069e-98	327.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,4H331@909932|Negativicutes	909932|Negativicutes	D	Sporulation initiation inhibitor protein Soj	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
MMS2_k127_956735_1	1118055.CAGU01000043_gene1457	9.066e-53	192.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,22GPQ@1570339|Peptoniphilaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
MMS2_k127_956735_2	272134.KB731324_gene5434	3.913e-11	70.0	COG4775@1|root,COG4775@2|Bacteria,1G389@1117|Cyanobacteria,1H8GG@1150|Oscillatoriales	1117|Cyanobacteria	M	Outer membrane protein protective antigen OMA87	IAP75	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA,POTRA_2
MMS2_k127_957474_0	635013.TherJR_2128	7.097e-93	320.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,260MY@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
MMS2_k127_961252_1	1122971.BAME01000083_gene5387	1.158e-12	76.0	COG2865@1|root,COG2865@2|Bacteria,4NG2T@976|Bacteroidetes,2FWGF@200643|Bacteroidia	976|Bacteroidetes	K	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AlbA_2,HATPase_c_4
MMS2_k127_961252_2	593117.TGAM_0975	2.904e-07	60.0	COG2865@1|root,COG3177@1|root,arCOG02559@1|root,arCOG02559@2157|Archaea,arCOG03110@2157|Archaea,arCOG03296@2157|Archaea,2XV8V@28890|Euryarchaeota,243W3@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_DeoR
MMS2_k127_961252_0	1242864.D187_007592	1.417e-111	376.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Fer4_9,PK,PK_C
MMS2_k127_96288_1	404589.Anae109_1278	7.652e-11	72.0	COG0613@1|root,COG0613@2|Bacteria,1QV9S@1224|Proteobacteria,43BP1@68525|delta/epsilon subdivisions,2X70C@28221|Deltaproteobacteria,2YWF9@29|Myxococcales	28221|Deltaproteobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
MMS2_k127_96288_0	880073.Calab_3750	6.883e-68	238.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972,ko:K10754	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	M00289,M00295	R00382	RC00005	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
MMS2_k127_964201_1	1329516.JPST01000048_gene1882	2.065e-69	249.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HB7D@91061|Bacilli,27BIZ@186824|Thermoactinomycetaceae	91061|Bacilli	O	Subtilase family	-	-	3.4.21.66	ko:K08651	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	PPC,Peptidase_S8
MMS2_k127_964201_0	1243664.CAVL020000028_gene78	4.209e-108	365.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,4H9M7@91061|Bacilli,1ZAZ9@1386|Bacillus	91061|Bacilli	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_965423_1	1047013.AQSP01000115_gene346	2.96e-35	137.0	COG2878@1|root,COG2878@2|Bacteria,2NPAJ@2323|unclassified Bacteria	2|Bacteria	C	Putative Fe-S cluster	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_4,Fer4_9
MMS2_k127_965423_0	665571.STHERM_c08610	1.059e-37	147.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
MMS2_k127_965423_2	1284708.HMPREF1634_08610	6.303e-19	89.0	COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,3WDD8@538999|Clostridiales incertae sedis	186801|Clostridia	O	PFAM Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
MMS2_k127_968553_0	289376.THEYE_A1682	6.342e-126	414.0	COG3635@1|root,COG3635@2|Bacteria,3J0YA@40117|Nitrospirae	40117|Nitrospirae	G	Metalloenzyme superfamily	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMS2_k127_968553_1	635013.TherJR_0824	7.45e-31	123.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,261MR@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMS2_k127_969231_0	909663.KI867150_gene357	4.056e-145	471.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MR6X@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Elongation factor Tu domain 2	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS2_k127_971574_2	398512.JQKC01000019_gene3388	1.516e-12	67.0	COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,3WHU8@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS2_k127_971574_0	697303.Thewi_0870	1.221e-65	233.0	28NMK@1|root,2ZBN3@2|Bacteria,1TT4K@1239|Firmicutes,24EKK@186801|Clostridia,42FUC@68295|Thermoanaerobacterales	186801|Clostridia	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	amj	-	-	-	-	-	-	-	-	-	-	-	Amj
MMS2_k127_971574_1	335543.Sfum_3182	1.051e-33	134.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2MQCP@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
MMS2_k127_975563_1	1443125.Z962_00905	2.305e-47	173.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,36UJ5@31979|Clostridiaceae	186801|Clostridia	M	NAD-dependent epimerase dehydratase	-	-	4.2.1.45,4.2.1.46	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R02426,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
MMS2_k127_975563_0	941449.dsx2_1099	1.941e-68	244.0	COG2227@1|root,COG2227@2|Bacteria,1RKH0@1224|Proteobacteria,42Q2I@68525|delta/epsilon subdivisions,2WJME@28221|Deltaproteobacteria,2M9G0@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
MMS2_k127_975563_2	290318.Cvib_0675	7.885e-11	66.0	COG0438@1|root,COG0438@2|Bacteria,1FEV3@1090|Chlorobi	1090|Chlorobi	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS2_k127_976876_1	742735.HMPREF9467_01096	3.222e-19	91.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,220VX@1506553|Lachnoclostridium	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
MMS2_k127_976876_2	1562701.BBOF01000077_gene130	1.497e-17	85.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,1K8CW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS2_k127_976876_0	1089548.KI783301_gene230	2.244e-38	151.0	COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HJPK@91061|Bacilli	91061|Bacilli	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
MMS2_k127_98421_1	555079.Toce_2268	1.667e-13	78.0	COG0739@1|root,COG4487@1|root,COG0739@2|Bacteria,COG4487@2|Bacteria,1V3ZU@1239|Firmicutes,24JM4@186801|Clostridia,42FFZ@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
MMS2_k127_98421_2	562973.HMPREF0059_00949	0.0008741	42.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4D3ZA@85005|Actinomycetales	201174|Actinobacteria	L	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
MMS2_k127_98421_0	42256.RradSPS_1898	4.094e-20	94.0	COG0344@1|root,COG0344@2|Bacteria,2IF8Y@201174|Actinobacteria,4CTSY@84995|Rubrobacteria	84995|Rubrobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
MMS2_k127_989624_2	887929.HMP0721_0669	3.194e-20	96.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,25WJB@186806|Eubacteriaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
MMS2_k127_989624_0	91464.S7335_397	2.156e-36	141.0	COG0730@1|root,COG0730@2|Bacteria,1G8K7@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS2_k127_989624_1	1158608.I583_00314	2.179e-21	95.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,4H9Z5@91061|Bacilli,4AZNU@81852|Enterococcaceae	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
MMS2_k127_998455_0	1379281.AVAG01000028_gene141	6.835e-158	507.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2M9A5@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS2_k127_998455_1	251221.35214841	1.077e-101	338.0	COG0484@1|root,COG0484@2|Bacteria,1G0IY@1117|Cyanobacteria	1117|Cyanobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
## 1149 queries scanned
## Total time (seconds): 108.81668710708618
## Rate: 10.56 q/s