## Fri Nov 15 06:26:27 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin17/MMS_2_bin.78.fa -m mmseqs --itype genome -o MMS_2_bin.78 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_2_bin.78 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS2_k127_1002531_1	471857.Svir_26930	0.0002596	52.0	COG0726@1|root,COG1215@1|root,COG1835@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG1835@2|Bacteria,2GJCE@201174|Actinobacteria,4DZV9@85010|Pseudonocardiales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Glyco_tranf_2_3,Polysacc_deac_1
MMS2_k127_1002531_0	1198114.AciX9_0574	1.492e-11	74.0	COG0500@1|root,COG2226@2|Bacteria,3Y58M@57723|Acidobacteria,2JJRE@204432|Acidobacteriia	204432|Acidobacteriia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS2_k127_1012132_2	273116.14325133	3.307e-43	167.0	arCOG03534@1|root,arCOG03534@2157|Archaea	2157|Archaea	S	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_1012132_0	273116.14325566	9.164e-181	572.0	COG0183@1|root,arCOG01282@2157|Archaea,2XT8C@28890|Euryarchaeota,2423Q@183967|Thermoplasmata	183967|Thermoplasmata	I	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_1012132_1	273075.Ta0295m	3.889e-140	454.0	COG1960@1|root,arCOG01708@2157|Archaea,2Y7GC@28890|Euryarchaeota,24217@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_1012132_3	926559.JoomaDRAFT_2788	1.374e-05	53.0	COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,1HWV4@117743|Flavobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_1019040_1	273075.Ta1160	4e-17	84.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,241WT@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
MMS2_k127_1019040_0	673860.AciM339_0956	1.885e-209	672.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,3F2F7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0543	Anticodon_1,tRNA-synt_1g,tRNA_bind
MMS2_k127_1019040_2	263820.PTO1272	9.4e-10	62.0	arCOG05400@1|root,arCOG05400@2157|Archaea,2Y4Y7@28890|Euryarchaeota,242CG@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1024347_2	263820.PTO0879	1.65e-80	277.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,241NE@183967|Thermoplasmata	183967|Thermoplasmata	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
MMS2_k127_1024347_0	273116.14325348	3.355e-200	638.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,241JP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMS2_k127_1024347_4	273075.Ta0943	1.73e-16	81.0	COG1873@1|root,arCOG02155@2157|Archaea	2157|Archaea	S	PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS2_k127_1024347_3	273075.Ta0944m	5.847e-75	256.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,241QC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMS2_k127_1024347_1	273116.14325351	1.094e-157	499.0	COG1405@1|root,arCOG01981@2157|Archaea,2XU76@28890|Euryarchaeota,2422B@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbB	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS2_k127_1024415_2	263820.PTO0868	2.993e-31	127.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,241XB@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF359)	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
MMS2_k127_1024415_3	273116.14324697	6.342e-29	118.0	COG2004@1|root,arCOG04182@2157|Archaea,2Y7BU@28890|Euryarchaeota,242EA@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
MMS2_k127_1024415_4	263820.PTO0870	8.89e-19	87.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,241WR@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMS2_k127_1024415_1	273116.14324694	3.051e-108	362.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,241YK@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
MMS2_k127_1024415_0	273075.Ta0587	0.0	1593.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241JN@183967|Thermoplasmata	183967|Thermoplasmata	K	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS2_k127_1026944_0	263820.PTO0840	1.882e-275	861.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,241JG@183967|Thermoplasmata	183967|Thermoplasmata	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS2_k127_1026944_2	263820.PTO0839	5.152e-29	123.0	COG0576@1|root,arCOG04772@2157|Archaea,2Y6XU@28890|Euryarchaeota,241XI@183967|Thermoplasmata	183967|Thermoplasmata	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMS2_k127_1026944_1	263820.PTO0412	2.892e-67	241.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,241RT@183967|Thermoplasmata	183967|Thermoplasmata	L	Putative RNA methylase family UPF0020	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	UPF0020
MMS2_k127_1026944_3	273116.14325701	7.645e-07	51.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,241XD@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
MMS2_k127_1027776_3	273075.Ta0835	3.628e-21	95.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,241JB@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMS2_k127_1027776_2	263820.PTO1379	1.315e-64	233.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,241R8@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS2_k127_1027776_0	263820.PTO1378	1.492e-107	353.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,241N5@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMS2_k127_1027776_1	273116.14324814	3.99e-89	304.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,241M9@183967|Thermoplasmata	183967|Thermoplasmata	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
MMS2_k127_1033158_0	273116.14325390	2.199e-264	822.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IK@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS2_k127_1033158_1	273116.14325710	3.62e-15	76.0	COG1351@1|root,arCOG01884@2157|Archaea,2Y7AA@28890|Euryarchaeota,2420S@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
MMS2_k127_1037903_1	1120971.AUCA01000022_gene543	5.068e-92	308.0	COG1072@1|root,COG1072@2|Bacteria,1TPHJ@1239|Firmicutes,4HA4K@91061|Bacilli	91061|Bacilli	F	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
MMS2_k127_1037903_0	930945.SiRe_0569	1.043e-92	319.0	COG0477@1|root,arCOG02691@2157|Archaea,2XRK4@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_1037903_2	263820.PTO0978	6.117e-08	57.0	arCOG06972@1|root,arCOG06972@2157|Archaea,2Y4W6@28890|Euryarchaeota,242C4@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1061927_0	1056495.Calag_1003	6.194e-77	289.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1061927_1	1379698.RBG1_1C00001G0821	1.288e-48	188.0	COG0798@1|root,COG0798@2|Bacteria,2NNWJ@2323|unclassified Bacteria	2|Bacteria	P	Sodium Bile acid symporter family	arsB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656	1.20.4.1	ko:K03325,ko:K03741	-	-	-	-	ko00000,ko01000,ko02000	2.A.59	-	iYO844.BSU25790	SBF
MMS2_k127_1061927_3	273075.Ta1110	1.065e-18	90.0	COG0640@1|root,arCOG01681@2157|Archaea	2157|Archaea	K	regulatory protein, arsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
MMS2_k127_1061927_2	1151117.AJLF01000001_gene1426	6.967e-33	132.0	COG1670@1|root,arCOG00842@2157|Archaea,2XVC6@28890|Euryarchaeota,243ZK@183968|Thermococci	183968|Thermococci	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_1085597_0	945713.IALB_1465	3.21e-149	495.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_1085597_1	273116.14325648	3.628e-70	244.0	COG2086@1|root,arCOG00446@2157|Archaea,2XZ39@28890|Euryarchaeota,24263@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS2_k127_1091861_2	273075.Ta0192m	2.146e-23	106.0	COG0500@1|root,arCOG01793@2157|Archaea,2Y1JK@28890|Euryarchaeota,242DW@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS2_k127_1091861_1	285535.JOEY01000001_gene5116	2.461e-48	182.0	COG4106@1|root,COG4106@2|Bacteria,2GK0K@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase	metZ	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS2_k127_1091861_3	1122611.KB903988_gene7173	8.262e-08	57.0	2EFVT@1|root,339N0@2|Bacteria,2GWUH@201174|Actinobacteria,4EKY7@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1091861_0	632335.Calkr_1613	4.283e-72	251.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,42G63@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMS2_k127_1094476_0	273116.14324573	4.184e-114	376.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,241K9@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMS2_k127_1094476_2	273116.14324575	9.454e-29	117.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y6AG@28890|Euryarchaeota,242DM@183967|Thermoplasmata	183967|Thermoplasmata	J	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS2_k127_1094476_1	521098.Aaci_1457	3.744e-93	312.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4HASW@91061|Bacilli	91061|Bacilli	I	Belongs to the thiolase family	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_1097097_1	380394.Lferr_2097	1.177e-12	72.0	2E48M@1|root,32Z4G@2|Bacteria,1N6NZ@1224|Proteobacteria,1T8S2@1236|Gammaproteobacteria,2NDBV@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1097097_2	161156.JQKW01000007_gene812	8.475e-07	53.0	COG1872@1|root,COG1872@2|Bacteria,2GI49@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Uncharacterised ACR, YggU family COG1872	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
MMS2_k127_1097097_0	1191523.MROS_0915	7.853e-75	265.0	COG3590@1|root,COG3590@2|Bacteria	2|Bacteria	O	peptidase	pepO	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
MMS2_k127_1099888_2	273116.14325283	1.103e-42	160.0	COG0025@1|root,arCOG01961@2157|Archaea,2XT52@28890|Euryarchaeota,24223@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS2_k127_1099888_1	273075.Ta0899	8.507e-67	235.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,241S8@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
MMS2_k127_1099888_0	273075.Ta0898	1.022e-82	283.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,241PA@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMS2_k127_1105804_0	273116.14325462	2.059e-238	750.0	COG2366@1|root,arCOG04082@2157|Archaea,2XT02@28890|Euryarchaeota,241ZQ@183967|Thermoplasmata	183967|Thermoplasmata	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
MMS2_k127_1121756_1	263820.PTO1067	1.514e-44	163.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,24255@183967|Thermoplasmata	183967|Thermoplasmata	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMS2_k127_1121756_0	324602.Caur_1056	3.66e-76	264.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,374VN@32061|Chloroflexia	32061|Chloroflexia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS2_k127_1121756_2	273075.Ta0892	1.033e-32	133.0	COG4198@1|root,arCOG03573@2157|Archaea,2XZJQ@28890|Euryarchaeota,241UW@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
MMS2_k127_1132188_0	273116.14325439	1.251e-168	538.0	COG1960@1|root,arCOG04310@2157|Archaea,2XXBZ@28890|Euryarchaeota,2426V@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_1132188_1	1547437.LL06_13730	6.132e-90	313.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,43GV8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_1132188_2	395961.Cyan7425_1835	1.814e-46	175.0	COG1748@1|root,COG1748@2|Bacteria,1G37A@1117|Cyanobacteria	1117|Cyanobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
MMS2_k127_1145820_0	263820.PTO1284	1.674e-168	542.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,241KA@183967|Thermoplasmata	183967|Thermoplasmata	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
MMS2_k127_1145820_4	263820.PTO1285	2.888e-27	123.0	COG0530@1|root,arCOG02881@2157|Archaea,2Y7DS@28890|Euryarchaeota,242GN@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMS2_k127_1145820_2	263820.PTO1286	3.582e-43	161.0	COG1586@1|root,arCOG00279@2157|Archaea,2XXWH@28890|Euryarchaeota,242A3@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
MMS2_k127_1145820_3	263820.PTO1287	1.329e-40	159.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,24299@183967|Thermoplasmata	183967|Thermoplasmata	K	Regulatory protein Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	-
MMS2_k127_1145820_1	263820.PTO1260	2.074e-46	173.0	COG0321@1|root,arCOG01942@2157|Archaea	2157|Archaea	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS2_k127_1209103_1	273075.Ta0215	3.333e-50	181.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11781,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
MMS2_k127_1209103_0	273075.Ta0217	4.752e-132	430.0	COG1060@1|root,arCOG00656@2157|Archaea,2XW63@28890|Euryarchaeota	28890|Euryarchaeota	H	Radical SAM domain protein	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
MMS2_k127_1216091_6	1197130.BAFM01000015_gene2515	4.905e-13	70.0	COG1012@1|root,arCOG01252@2157|Archaea,2XUKB@28890|Euryarchaeota,23S5J@183963|Halobacteria	183963|Halobacteria	C	COG1012 NAD-dependent aldehyde dehydrogenases	aldH2	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_1216091_0	273116.14324792	5.11e-67	238.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,241ST@183967|Thermoplasmata	183967|Thermoplasmata	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMS2_k127_1216091_1	273116.14324793	5.735e-63	226.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,241SK@183967|Thermoplasmata	183967|Thermoplasmata	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
MMS2_k127_1216091_4	273116.14325396	1.145e-34	136.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,241WH@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
MMS2_k127_1216091_3	263820.PTO0323	5.932e-46	169.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,241TR@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS2_k127_1216091_2	273116.14325398	5.954e-49	177.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,241SC@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS2_k127_1216091_5	273116.14325399	2.591e-25	107.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,241XF@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMS2_k127_1216091_7	273063.STK_16120	0.0001134	46.0	COG1522@1|root,arCOG01586@2157|Archaea	2157|Archaea	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS2_k127_1239884_2	273116.14325435	2.035e-34	151.0	COG0457@1|root,arCOG03049@2157|Archaea	2157|Archaea	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1239884_1	273075.Ta0403	1.357e-78	270.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,241P3@183967|Thermoplasmata	183967|Thermoplasmata	F	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
MMS2_k127_1239884_0	273075.Ta0404	7.429e-117	383.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,241MJ@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
MMS2_k127_1239884_3	273075.Ta1306	1.544e-16	83.0	arCOG05325@1|root,arCOG05325@2157|Archaea,2Y5Z7@28890|Euryarchaeota,242GD@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1251568_4	263820.PTO1111	2.309e-31	124.0	COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,241QJ@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
MMS2_k127_1251568_3	273116.14325657	1.495e-61	219.0	COG2345@1|root,arCOG01691@2157|Archaea,2Y7BG@28890|Euryarchaeota,242BG@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
MMS2_k127_1251568_5	273116.14325688	6.38e-27	118.0	COG2345@1|root,arCOG01692@2157|Archaea	2157|Archaea	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS2_k127_1251568_0	273075.Ta0098	1.708e-229	719.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,241M7@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP-dependent peptidase activity	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
MMS2_k127_1251568_1	273075.Ta0097m	3.423e-173	553.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,241KR@183967|Thermoplasmata	183967|Thermoplasmata	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMS2_k127_1251568_2	263820.PTO0616	1.632e-80	271.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,241P4@183967|Thermoplasmata	183967|Thermoplasmata	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS2_k127_1273991_2	330779.Saci_2185	2.938e-35	143.0	COG2017@1|root,arCOG05361@2157|Archaea,2XRN3@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
MMS2_k127_1273991_1	273063.STK_22710	9.273e-96	324.0	COG2876@1|root,arCOG01049@2157|Archaea,2XQ1G@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM DAHP synthetase I	aroG	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS2_k127_1273991_3	263820.PTO0836	2.726e-30	128.0	COG0287@1|root,arCOG00256@2157|Archaea,2Y4RC@28890|Euryarchaeota,242D4@183967|Thermoplasmata	183967|Thermoplasmata	C	prephenate dehydrogenase (NADP+) activity	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_1273991_5	273075.Ta0245m	2.748e-11	72.0	COG1605@1|root,arCOG07365@2157|Archaea,2Y5S5@28890|Euryarchaeota,242F1@183967|Thermoplasmata	183967|Thermoplasmata	E	Chorismate mutase type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
MMS2_k127_1273991_0	1132509.C447_12120	5.139e-115	384.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,23UQF@183963|Halobacteria	183963|Halobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	-	-	1.1.1.308	ko:K15509	-	-	-	-	ko00000,ko01000	-	-	-	Histidinol_dh
MMS2_k127_1273991_4	290402.Cbei_4353	1.867e-16	91.0	COG0531@1|root,COG0531@2|Bacteria,1V01X@1239|Firmicutes,24AJM@186801|Clostridia,36GRZ@31979|Clostridiaceae	186801|Clostridia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
MMS2_k127_1318820_0	263820.PTO0439	7.241e-66	232.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,241SB@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMS2_k127_1318820_3	272844.PAB1168	5.865e-26	110.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,244BE@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
MMS2_k127_1318820_1	273075.Ta0357	5.453e-61	213.0	COG1225@1|root,arCOG00310@2157|Archaea,2XX5A@28890|Euryarchaeota,241TT@183967|Thermoplasmata	183967|Thermoplasmata	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS2_k127_1318820_2	273116.14325705	4.382e-32	130.0	COG2016@1|root,arCOG00985@2157|Archaea,2XX1R@28890|Euryarchaeota,241XH@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	-	ko:K07575	-	-	-	-	ko00000	-	-	-	DUF1947,PUA
MMS2_k127_1318820_4	263820.PTO0444	1.88e-11	70.0	arCOG05338@1|root,arCOG05338@2157|Archaea,2Y1WT@28890|Euryarchaeota,24288@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1338609_0	273075.Ta0356	1.653e-132	428.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,241J4@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS2_k127_1338609_7	263820.PTO1208	8.669e-29	121.0	COG5615@1|root,arCOG05392@2157|Archaea,2Y453@28890|Euryarchaeota,2429S@183967|Thermoplasmata	183967|Thermoplasmata	S	protein, homolog of Cu resistance protein CopC	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1338609_3	273116.14324377	3.687e-81	275.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,241NY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMS2_k127_1338609_5	263820.PTO0853	1.633e-72	248.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,241NK@183967|Thermoplasmata	183967|Thermoplasmata	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMS2_k127_1338609_2	263820.PTO0852	6.295e-108	364.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,241MD@183967|Thermoplasmata	183967|Thermoplasmata	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
MMS2_k127_1338609_6	273116.14325488	6.602e-52	186.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,241W0@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterised protein family (UPF0179)	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
MMS2_k127_1338609_1	263820.PTO0850	3.615e-131	427.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,241M3@183967|Thermoplasmata	183967|Thermoplasmata	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
MMS2_k127_1338609_4	439481.Aboo_0974	5.468e-78	269.0	COG1446@1|root,arCOG04779@2157|Archaea,2XTTT@28890|Euryarchaeota,3F316@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Asparaginase	ansA	-	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
MMS2_k127_134080_1	1459636.NTE_00052	2.744e-81	276.0	COG0125@1|root,arCOG01891@2157|Archaea	1459636.NTE_00052|-	F	thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_134080_0	1459636.NTE_00051	2.502e-91	305.0	COG0125@1|root,arCOG01891@2157|Archaea	2157|Archaea	F	thymidylate kinase	-	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS2_k127_1369982_4	309798.COPRO5265_0449	3.428e-05	49.0	COG0730@1|root,COG0730@2|Bacteria,1TRFG@1239|Firmicutes,24AEX@186801|Clostridia	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS2_k127_1369982_1	1051632.TPY_0190	9.778e-21	94.0	2E48M@1|root,32Z4G@2|Bacteria	2|Bacteria	-	-	MA20_36460	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1369982_3	930945.SiRe_0323	1.164e-17	89.0	COG1695@1|root,arCOG00002@2157|Archaea	2157|Archaea	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
MMS2_k127_1369982_2	374847.Kcr_0807	1.52e-20	105.0	COG0477@1|root,arCOG00130@2157|Archaea	374847.Kcr_0807|-	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1369982_0	1462526.BN990_00809	2.28e-152	492.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,4HCEB@91061|Bacilli,4C5EX@84406|Virgibacillus	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_1425693_3	273075.Ta1460	8.827e-38	153.0	COG1597@1|root,arCOG08932@2157|Archaea	2157|Archaea	I	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
MMS2_k127_1425693_2	446469.Sked_19490	2.325e-58	222.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS2_k127_1425693_0	273057.SSO2087	3.357e-72	252.0	COG0412@1|root,arCOG01659@2157|Archaea,2XRM2@28889|Crenarchaeota	28889|Crenarchaeota	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS2_k127_1425693_1	397948.Cmaq_1209	8.914e-62	221.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
MMS2_k127_1425693_4	390989.JOEG01000003_gene4702	4.241e-24	109.0	COG0842@1|root,COG0842@2|Bacteria,2GJ2G@201174|Actinobacteria,4DDT9@85008|Micromonosporales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS2_k127_143143_0	273075.Ta0144	2.306e-162	525.0	COG1653@1|root,arCOG00153@2157|Archaea,2Y3M5@28890|Euryarchaeota,24281@183967|Thermoplasmata	183967|Thermoplasmata	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17311	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	SBP_bac_1
MMS2_k127_143143_1	263820.PTO0312	5.629e-87	295.0	COG0451@1|root,arCOG04627@2157|Archaea,2Y34E@28890|Euryarchaeota,24206@183967|Thermoplasmata	183967|Thermoplasmata	M	GDP-mannose 4,6 dehydratase	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS2_k127_143143_3	273116.14325208	3.63e-06	55.0	COG2246@1|root,arCOG02228@2157|Archaea,2Y1ZX@28890|Euryarchaeota,242GP@183967|Thermoplasmata	183967|Thermoplasmata	S	GtrA-like protein	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	GtrA
MMS2_k127_143143_2	186497.PF0058	1.996e-78	274.0	COG0463@1|root,arCOG00894@2157|Archaea,2XWXA@28890|Euryarchaeota,242RY@183968|Thermococci	183968|Thermococci	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMS2_k127_1447930_1	1123255.JHYS01000017_gene1423	0.0006659	52.0	COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,2VJDE@28216|Betaproteobacteria,4AAX0@80864|Comamonadaceae	28216|Betaproteobacteria	S	ABC-2 family transporter protein	nosY	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
MMS2_k127_1447930_0	591019.Shell_0704	9.389e-61	218.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_1468539_2	1382306.JNIM01000001_gene2693	7.377e-41	160.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS2_k127_1468539_1	867903.ThesuDRAFT_01357	3.245e-55	197.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia	186801|Clostridia	C	aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS2_k127_1468539_0	263820.PTO1121	6.389e-187	603.0	COG1529@1|root,arCOG01167@2157|Archaea,2XSZN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS2_k127_1510803_2	273075.Ta0115	8.535e-61	213.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,241TE@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1510803_4	263820.PTO0596	1.262e-20	100.0	COG0169@1|root,arCOG02097@2157|Archaea,2Y5JG@28890|Euryarchaeota,242HC@183967|Thermoplasmata	183967|Thermoplasmata	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
MMS2_k127_1510803_1	263820.PTO0597	4.317e-68	237.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2426E@183967|Thermoplasmata	183967|Thermoplasmata	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS2_k127_1510803_3	273526.SMDB11_3949	1.859e-27	117.0	COG0537@1|root,COG0537@2|Bacteria,1R7GK@1224|Proteobacteria,1S0R0@1236|Gammaproteobacteria,402YV@613|Serratia	1236|Gammaproteobacteria	FG	HIT domain	hit	-	-	-	-	-	-	-	-	-	-	-	HIT
MMS2_k127_1510803_0	273075.Ta0421	3.443e-88	297.0	COG0365@1|root,arCOG04201@2157|Archaea,2Y84I@28890|Euryarchaeota,2424Z@183967|Thermoplasmata	183967|Thermoplasmata	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS2_k127_1549078_1	263820.PTO0863	1.645e-15	78.0	arCOG05368@1|root,arCOG05368@2157|Archaea,2Y1EG@28890|Euryarchaeota,241W5@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1549078_0	263820.PTO1429	5.054e-77	269.0	COG0350@1|root,COG1515@1|root,arCOG00929@2157|Archaea,arCOG02724@2157|Archaea,2XURE@28890|Euryarchaeota,24279@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Endonuclease_5
MMS2_k127_1600896_0	263820.PTO0477	4.648e-109	361.0	COG0626@1|root,arCOG00060@2157|Archaea,2XWWT@28890|Euryarchaeota,241ZJ@183967|Thermoplasmata	183967|Thermoplasmata	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
MMS2_k127_1600896_1	671065.MetMK1DRAFT_00011870	3.351e-60	219.0	COG0083@1|root,arCOG01027@2157|Archaea,2XQN1@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_1608715_0	263820.PTO0899	7.905e-144	469.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,241KM@183967|Thermoplasmata	183967|Thermoplasmata	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS2_k127_1608715_1	273116.14324447	8.828e-140	455.0	COG1902@1|root,arCOG00615@2157|Archaea,2XT27@28890|Euryarchaeota,241Z1@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8,Oxidored_FMN
MMS2_k127_1652559_1	273116.14324314	2.356e-51	183.0	COG0022@1|root,arCOG01052@2157|Archaea,2XT3K@28890|Euryarchaeota,2420C@183967|Thermoplasmata	183967|Thermoplasmata	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS2_k127_1652559_0	273116.14324313	7.195e-115	382.0	COG0508@1|root,arCOG01706@2157|Archaea,2XTSS@28890|Euryarchaeota,2421N@183967|Thermoplasmata	183967|Thermoplasmata	C	Biotin-lipoyl like	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS2_k127_1652559_2	273075.Ta1435	1.159e-45	168.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,2423A@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS2_k127_1661605_3	1122917.KB899662_gene2233	3.279e-29	125.0	COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,4H9WX@91061|Bacilli,26RW8@186822|Paenibacillaceae	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS2_k127_1661605_0	273116.14324304	5.668e-124	403.0	COG3404@1|root,arCOG05394@2157|Archaea,2XX41@28890|Euryarchaeota,2420F@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the formyl group from N- formylglutamate to tetrahydrofolate (THF) to yield 5- formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5-formiminotetrahydrofolate (5-NH CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrofolate (5,10-CH THF)	-	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
MMS2_k127_1661605_2	403833.Pmob_1031	1.808e-32	134.0	COG3404@1|root,COG3404@2|Bacteria,2GD2A@200918|Thermotogae	200918|Thermotogae	E	PFAM Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
MMS2_k127_1661605_1	315750.BPUM_3683	4.117e-38	147.0	COG0454@1|root,COG0456@2|Bacteria,1VAU8@1239|Firmicutes,4HMA6@91061|Bacilli,1ZFP4@1386|Bacillus	91061|Bacilli	K	Acetyltransferase	yycN	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_1672187_3	273116.14325297	2.025e-19	90.0	COG2226@1|root,arCOG04348@2157|Archaea,2Y6PI@28890|Euryarchaeota,242CN@183967|Thermoplasmata	183967|Thermoplasmata	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS2_k127_1672187_0	263820.PTO0346	9.595e-183	580.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,241KU@183967|Thermoplasmata	183967|Thermoplasmata	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_1672187_2	263820.PTO0345	4.576e-61	218.0	COG0159@1|root,arCOG01086@2157|Archaea,2Y7BP@28890|Euryarchaeota,242D7@183967|Thermoplasmata	183967|Thermoplasmata	E	Tryptophan synthase alpha chain	-	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
MMS2_k127_1672187_1	263820.PTO0344	9.936e-75	262.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,241QR@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
MMS2_k127_1685955_2	439481.Aboo_1152	5.57e-08	56.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,3F2GS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2a	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMS2_k127_1685955_1	273075.Ta1202	2.01e-13	70.0	COG2260@1|root,arCOG00906@2157|Archaea	2157|Archaea	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMS2_k127_1685955_0	273116.14324627	3.971e-107	353.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,241Q6@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMS2_k127_1685955_4	1449346.JQMO01000003_gene2635	0.0001874	54.0	2AARV@1|root,31047@2|Bacteria,2ICQH@201174|Actinobacteria,2M4NZ@2063|Kitasatospora	201174|Actinobacteria	S	Peptidase A4 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_A4
MMS2_k127_1685955_3	273116.14325382	1.371e-06	51.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,2425E@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_1732381_2	273116.14324453	4.124e-06	58.0	arCOG03675@1|root,arCOG06052@1|root,arCOG03675@2157|Archaea,arCOG06052@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB,Thermopsin
MMS2_k127_1732381_0	273075.Ta0544	9.246e-51	185.0	COG0241@1|root,arCOG07384@2157|Archaea,2Y0DK@28890|Euryarchaeota,242CA@183967|Thermoplasmata	183967|Thermoplasmata	E	Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PNK3P
MMS2_k127_1732381_1	399549.Msed_1286	2.502e-24	106.0	COG3839@1|root,arCOG00175@2157|Archaea,2XSP8@28889|Crenarchaeota	28889|Crenarchaeota	G	ATPases associated with a variety of cellular activities	-	-	-	ko:K17314	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	ABC_tran
MMS2_k127_174069_2	263820.PTO0265	7.908e-44	166.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,241VE@183967|Thermoplasmata	183967|Thermoplasmata	S	TatD related DNase	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
MMS2_k127_174069_4	263820.PTO0266	3.368e-17	89.0	COG1711@1|root,arCOG00551@2157|Archaea,2Y7CG@28890|Euryarchaeota,242DH@183967|Thermoplasmata	183967|Thermoplasmata	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
MMS2_k127_174069_3	273075.Ta1047a	3.031e-17	85.0	arCOG05330@1|root,arCOG05330@2157|Archaea,2Y24Y@28890|Euryarchaeota,242GS@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_174069_1	673860.AciM339_0524	3.877e-91	307.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_174069_0	273116.14325002	2.558e-107	351.0	COG1884@1|root,arCOG04232@2157|Archaea,2XU3F@28890|Euryarchaeota,24230@183967|Thermoplasmata	183967|Thermoplasmata	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS2_k127_1777292_4	273075.Ta0953m	2.14e-30	125.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMS2_k127_1777292_2	1131266.ARWQ01000001_gene1124	7.861e-149	480.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS2_k127_1777292_1	273075.Ta1212	8.935e-167	529.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,241IN@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
MMS2_k127_1777292_5	273116.14325447	7.279e-25	106.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y6HJ@28890|Euryarchaeota,241W1@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMS2_k127_1777292_0	273075.Ta0390	0.0	1924.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,241IZ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS2_k127_1777292_3	273116.14325445	3.015e-78	264.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,241IQ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS2_k127_1786560_1	572478.Vdis_1443	9.901e-137	447.0	COG2223@1|root,arCOG00148@2157|Archaea,2XRTQ@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
MMS2_k127_1786560_0	273116.14324489	2.677e-174	553.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,24256@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP-grasp domain	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMS2_k127_1786560_2	273116.14324488	2.654e-135	435.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota,24232@183967|Thermoplasmata	183967|Thermoplasmata	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
MMS2_k127_1786560_3	273075.Ta1330	6.898e-122	398.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,241JI@183967|Thermoplasmata	183967|Thermoplasmata	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	arcB	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS2_k127_1786560_5	263820.PTO0719	2.36e-32	128.0	arCOG05358@1|root,arCOG05358@2157|Archaea,2Y1IF@28890|Euryarchaeota,242CT@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1786560_4	263820.PTO0718	3.846e-42	161.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,241V0@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
MMS2_k127_1786560_6	273116.14325338	1.79e-25	106.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0B2@28890|Euryarchaeota,242CV@183967|Thermoplasmata	183967|Thermoplasmata	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS2_k127_1786560_9	273116.14325339	1.979e-10	62.0	arCOG06962@1|root,arCOG06962@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1786560_8	1236689.MMALV_01710	2.27e-16	81.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
MMS2_k127_18115_1	263820.PTO0145	1.161e-61	225.0	COG1226@1|root,arCOG01958@2157|Archaea,2Y66E@28890|Euryarchaeota,2429Q@183967|Thermoplasmata	183967|Thermoplasmata	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_N
MMS2_k127_18115_2	273116.14325357	4.619e-37	145.0	COG0720@1|root,arCOG02172@2157|Archaea,2XXFY@28890|Euryarchaeota,241WN@183967|Thermoplasmata	183967|Thermoplasmata	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMS2_k127_18115_0	273075.Ta0951	1.702e-67	235.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,241MS@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS2_k127_1813073_1	263820.PTO0386	1.086e-46	175.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,241VH@183967|Thermoplasmata	183967|Thermoplasmata	J	Ribosomal RNA adenine dimethylases	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMS2_k127_1813073_0	263820.PTO0385	1.047e-102	341.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,241RS@183967|Thermoplasmata	183967|Thermoplasmata	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS2_k127_1813073_2	439481.Aboo_0836	2.436e-19	90.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,3F38W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosyl transferase domain	-	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
MMS2_k127_1817734_3	387631.Asulf_00955	6.992e-18	91.0	arCOG07100@1|root,arCOG07100@2157|Archaea,2XZZK@28890|Euryarchaeota,2470E@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
MMS2_k127_1817734_1	273075.Ta1236	2.109e-38	152.0	arCOG07408@1|root,arCOG07408@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1817734_2	273075.Ta1218	4.049e-20	96.0	COG1522@1|root,arCOG01585@2157|Archaea,2XYZV@28890|Euryarchaeota,242G8@183967|Thermoplasmata	183967|Thermoplasmata	K	Archaeal TRASH domain	-	-	-	-	-	-	-	-	-	-	-	-	Arc_trans_TRASH,HTH_24
MMS2_k127_1817734_4	529709.PYCH_08970	1.788e-10	62.0	COG3350@1|root,arCOG04507@2157|Archaea,2Y1MF@28890|Euryarchaeota,244R8@183968|Thermococci	183968|Thermococci	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
MMS2_k127_1817734_0	273116.14325502	2.247e-158	516.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,241II@183967|Thermoplasmata	183967|Thermoplasmata	P	YHS domain	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
MMS2_k127_1819328_0	273116.14324331	3.725e-111	373.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,241NH@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMS2_k127_1819328_2	273116.14324330	6.716e-07	54.0	COG2104@1|root,arCOG00535@2157|Archaea,2Y5Q5@28890|Euryarchaeota,242FE@183967|Thermoplasmata	183967|Thermoplasmata	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
MMS2_k127_1819328_3	604354.TSIB_1586	5.332e-05	45.0	COG1011@1|root,arCOG02291@2157|Archaea,2Y2J0@28890|Euryarchaeota,2430U@183968|Thermococci	183968|Thermococci	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS2_k127_1819328_1	273116.14324306	3.953e-78	269.0	COG1576@1|root,arCOG00502@2157|Archaea,2XZ8Z@28890|Euryarchaeota,241TX@183967|Thermoplasmata	183967|Thermoplasmata	J	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMS2_k127_1874648_1	263820.PTO1341	9.727e-46	175.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,241UX@183967|Thermoplasmata	183967|Thermoplasmata	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
MMS2_k127_1874648_0	263820.PTO0779	2.654e-73	261.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7AR@28890|Euryarchaeota,2426M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_1877649_2	397948.Cmaq_0187	1.37e-71	248.0	COG1584@1|root,arCOG03176@2157|Archaea	2157|Archaea	S	GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMS2_k127_1877649_5	747365.Thena_1368	5.823e-36	139.0	COG2920@1|root,COG2920@2|Bacteria,1V6WF@1239|Firmicutes,24JRH@186801|Clostridia,42GKQ@68295|Thermoanaerobacterales	186801|Clostridia	P	TIGRFAM sulfur relay protein, TusE DsrC DsvC family	-	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
MMS2_k127_1877649_3	397948.Cmaq_0853	3.24e-68	247.0	COG2221@1|root,arCOG02057@2157|Archaea	2157|Archaea	C	PFAM nitrite and sulphite reductase 4Fe-4S	-	GO:0005575,GO:0016020	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
MMS2_k127_1877649_1	572478.Vdis_2099	7.561e-83	287.0	COG2221@1|root,arCOG02059@2157|Archaea	2157|Archaea	C	Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	-	GO:0003674,GO:0003824,GO:0005575,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016002,GO:0016020,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0044237,GO:0050311,GO:0055114	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr
MMS2_k127_1877649_9	138119.DSY0312	1.765e-15	85.0	COG2181@1|root,COG2181@2|Bacteria,1UYRK@1239|Firmicutes,24FM8@186801|Clostridia,266ZT@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitrate reductase gamma subunit	hmeC	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_gam
MMS2_k127_1877649_0	397948.Cmaq_0851	4.44e-131	433.0	COG0247@1|root,arCOG00333@2157|Archaea,2XPX6@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_1877649_6	273063.STK_06160	9.084e-30	122.0	COG2210@1|root,arCOG02065@2157|Archaea	2157|Archaea	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS2_k127_1877649_4	621372.ACIH01000144_gene162	8.466e-51	189.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,4HBB7@91061|Bacilli,26R9W@186822|Paenibacillaceae	91061|Bacilli	H	Belongs to the precorrin methyltransferase family	hemX	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
MMS2_k127_1877649_7	340099.Teth39_1888	6.04e-18	91.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,42EMC@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_1877649_8	273075.Ta0365	1.839e-17	83.0	COG0582@1|root,arCOG01241@2157|Archaea,2XWM9@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_191118_7	263820.PTO0985	2.976e-85	295.0	COG2244@1|root,arCOG02209@2157|Archaea,2XZR0@28890|Euryarchaeota,2422Z@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
MMS2_k127_191118_4	263820.PTO0873	8.365e-96	328.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,241QY@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
MMS2_k127_191118_15	273075.Ta0867	9.573e-08	56.0	COG1369@1|root,arCOG01365@2157|Archaea	2157|Archaea	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
MMS2_k127_191118_6	273116.14324750	4.549e-92	306.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,241PP@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMS2_k127_191118_11	1343739.PAP_07760	3.273e-39	152.0	COG1670@1|root,arCOG00842@2157|Archaea,2XVC6@28890|Euryarchaeota,243ZK@183968|Thermococci	183968|Thermococci	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_191118_14	311424.DhcVS_130	2.278e-14	76.0	COG2972@1|root,COG2972@2|Bacteria,2GAV9@200795|Chloroflexi,34DF0@301297|Dehalococcoidia	301297|Dehalococcoidia	T	2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	2TM
MMS2_k127_191118_2	273116.14325565	4.049e-110	370.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,241NG@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMS2_k127_191118_3	273116.14324729	4.659e-96	319.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,241N9@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS2_k127_191118_12	368407.Memar_0787	1.127e-37	154.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,2N9K8@224756|Methanomicrobia	224756|Methanomicrobia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMS2_k127_191118_5	263820.PTO1516	1.09e-93	317.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,241MV@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMS2_k127_191118_13	273116.14324746	1.524e-16	85.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y535@28890|Euryarchaeota,242FG@183967|Thermoplasmata	183967|Thermoplasmata	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMS2_k127_191118_1	273075.Ta1075	5.717e-160	513.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,241MF@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoglycerate kinase activity	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS2_k127_191118_10	273116.14324744	4.045e-55	202.0	COG1208@1|root,arCOG00664@2157|Archaea,2Y46V@28890|Euryarchaeota,242A9@183967|Thermoplasmata	183967|Thermoplasmata	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS2_k127_191118_0	273116.14324743	9.366e-179	567.0	COG0451@1|root,arCOG04762@2157|Archaea,2XU8F@28890|Euryarchaeota,241XT@183967|Thermoplasmata	183967|Thermoplasmata	M	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_191118_9	273075.Ta1070	1.931e-60	214.0	COG2095@1|root,arCOG01997@2157|Archaea,2Y3FF@28890|Euryarchaeota,2426A@183967|Thermoplasmata	183967|Thermoplasmata	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS2_k127_191118_8	1259795.ARJK01000002_gene154	9.36e-77	264.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,42G07@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
MMS2_k127_191118_16	658086.HMPREF0994_02264	0.0005955	49.0	2BC97@1|root,325U8@2|Bacteria,1URUH@1239|Firmicutes,24XUY@186801|Clostridia	186801|Clostridia	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
MMS2_k127_1918450_0	263820.PTO0342	1.167e-70	253.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,241T2@183967|Thermoplasmata	183967|Thermoplasmata	E	chorismate binding enzyme	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
MMS2_k127_1918450_1	263820.PTO0343	1.088e-16	87.0	COG0135@1|root,arCOG01983@2157|Archaea,2Y7BT@28890|Euryarchaeota,242BQ@183967|Thermoplasmata	183967|Thermoplasmata	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
MMS2_k127_1931283_3	263820.PTO0815	2.447e-83	285.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2Y6AX@28890|Euryarchaeota,242CM@183967|Thermoplasmata	183967|Thermoplasmata	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_1931283_0	273116.14324302	1.001e-222	703.0	COG2759@1|root,arCOG04541@2157|Archaea,2XUXB@28890|Euryarchaeota,241K6@183967|Thermoplasmata	183967|Thermoplasmata	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMS2_k127_1931283_5	877455.Metbo_0667	1.573e-40	159.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,23PCK@183925|Methanobacteria	183925|Methanobacteria	C	indolepyruvate ferredoxin oxidoreductase, beta subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
MMS2_k127_1931283_1	673860.AciM339_0762	2.664e-187	603.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
MMS2_k127_1931283_4	673860.AciM339_0745	4.874e-42	162.0	COG1042@1|root,arCOG01338@2157|Archaea,2Y39C@28890|Euryarchaeota,3F35C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	ATP-grasp domain	-	-	6.2.1.13	ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5
MMS2_k127_1931283_2	439481.Aboo_0319	1.689e-117	393.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,3F326@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	CoA binding domain	acdA	-	6.2.1.13	ko:K01905	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	CoA_binding_2,Succ_CoA_lig
MMS2_k127_1931283_6	273075.Ta0012	5.99e-09	60.0	arCOG07353@1|root,arCOG07353@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1953651_1	330779.Saci_2243	5.922e-80	276.0	COG5424@1|root,arCOG06031@2157|Archaea,2XRWB@28889|Crenarchaeota	28889|Crenarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4,zf-C2H2_9
MMS2_k127_1953651_3	273063.STK_26070	3.833e-29	118.0	arCOG06030@1|root,arCOG06030@2157|Archaea,2XS4E@28889|Crenarchaeota	28889|Crenarchaeota	S	Ta0938	-	-	-	-	-	-	-	-	-	-	-	-	Ta0938
MMS2_k127_1953651_2	367336.OM2255_07120	6.141e-51	195.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Methionine synthase	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
MMS2_k127_1953651_0	273075.Ta1069	3.492e-86	299.0	COG0477@1|root,arCOG00132@2157|Archaea,2Y66G@28890|Euryarchaeota,2423W@183967|Thermoplasmata	183967|Thermoplasmata	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_1953651_4	997346.HMPREF9374_1780	7.635e-24	112.0	COG3173@1|root,COG3173@2|Bacteria,1TPYB@1239|Firmicutes,4HBYQ@91061|Bacilli,27CG9@186824|Thermoactinomycetaceae	91061|Bacilli	S	Phosphotransferase enzyme family	ycbJ	-	-	ko:K06979	-	M00760	-	-	br01600,ko00000,ko00002,ko01504	-	-	-	APH
MMS2_k127_1953651_5	697303.Thewi_1848	2.824e-05	51.0	COG1433@1|root,COG1433@2|Bacteria,1VFDZ@1239|Firmicutes,24R8N@186801|Clostridia,42GPN@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
MMS2_k127_199923_2	1313301.AUGC01000006_gene67	2.875e-18	86.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes	976|Bacteroidetes	E	4-hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
MMS2_k127_199923_1	263820.PTO0818	2.958e-55	201.0	COG3253@1|root,arCOG03031@2157|Archaea,2Y3V1@28890|Euryarchaeota,2427W@183967|Thermoplasmata	183967|Thermoplasmata	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
MMS2_k127_199923_0	273075.Ta0506m	8.38e-106	357.0	COG0301@1|root,COG0607@1|root,arCOG00038@2157|Archaea,arCOG02021@2157|Archaea,2XUHM@28890|Euryarchaeota,241US@183967|Thermoplasmata	183967|Thermoplasmata	HP	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rhodanese,THUMP,ThiI
MMS2_k127_2008782_3	273075.Ta0591	1.495e-11	77.0	COG0433@1|root,arCOG04034@2157|Archaea,2Y7QK@28890|Euryarchaeota,242BW@183967|Thermoplasmata	183967|Thermoplasmata	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMS2_k127_2008782_1	263820.PTO0903	1.398e-20	103.0	arCOG05369@1|root,arCOG05369@2157|Archaea,2Y5KQ@28890|Euryarchaeota,242GV@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2008782_2	273116.14324853	3.45e-20	94.0	arCOG15086@1|root,arCOG15086@2157|Archaea,2Y5IR@28890|Euryarchaeota,242F8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2008782_0	273075.Ta0599	1.472e-50	184.0	COG1607@1|root,arCOG00773@2157|Archaea,2XXDM@28890|Euryarchaeota,24296@183967|Thermoplasmata	183967|Thermoplasmata	I	Thioesterase superfamily	-	-	3.1.2.20	ko:K01073	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS2_k127_2009391_1	273075.Ta0839	8.553e-15	80.0	COG0750@1|root,arCOG00609@2157|Archaea,2Y3DV@28890|Euryarchaeota,2425X@183967|Thermoplasmata	183967|Thermoplasmata	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2009391_0	263820.PTO0423	6.041e-156	515.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,241UG@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS2_k127_2031671_7	273075.Ta0323m	5.686e-49	177.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,241VJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMS2_k127_2031671_1	263820.PTO0592	1.24e-193	610.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,241M1@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
MMS2_k127_2031671_6	263820.PTO0593	2.008e-50	188.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,2428J@183967|Thermoplasmata	183967|Thermoplasmata	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
MMS2_k127_2031671_3	273116.14325540	1.337e-146	476.0	COG0644@1|root,arCOG00570@2157|Archaea,2XV3Q@28890|Euryarchaeota,242AZ@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
MMS2_k127_2031671_8	273116.14325541	5.685e-46	166.0	COG2440@1|root,arCOG01984@2157|Archaea,2XYN9@28890|Euryarchaeota,242HR@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO
MMS2_k127_2031671_5	273116.14325542	3.993e-93	312.0	COG2086@1|root,arCOG00446@2157|Archaea,2XTB8@28890|Euryarchaeota	28890|Euryarchaeota	C	Electron transfer flavoprotein, beta subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS2_k127_2031671_4	273116.14325543	4.004e-113	374.0	COG2025@1|root,arCOG00447@2157|Archaea,2XT06@28890|Euryarchaeota	28890|Euryarchaeota	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS2_k127_2031671_0	263820.PTO0594	1.206e-245	776.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,241KD@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
MMS2_k127_2031671_2	273116.14325616	1.49e-152	497.0	COG2986@1|root,arCOG04671@2157|Archaea,2XUUM@28890|Euryarchaeota,241ZU@183967|Thermoplasmata	183967|Thermoplasmata	E	histidine ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMS2_k127_2031671_9	273116.14325548	5.517e-17	88.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y10D@28890|Euryarchaeota,242AI@183967|Thermoplasmata	183967|Thermoplasmata	S	ribosomal small subunit binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2084624_2	263820.PTO1299	5.728e-11	68.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_2084624_0	273063.STK_17010	2.111e-178	581.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_2084624_1	88036.EFJ35899	3.275e-13	80.0	KOG0088@1|root,KOG0088@2759|Eukaryota,37P4T@33090|Viridiplantae,3GFRE@35493|Streptophyta	35493|Streptophyta	U	Ras family	-	-	-	ko:K07890	-	-	-	-	ko00000,ko04031,ko04131,ko04147	-	-	-	Ras
MMS2_k127_2112898_3	263820.PTO0951	2.637e-27	117.0	COG1386@1|root,arCOG02613@2157|Archaea	2157|Archaea	K	Segregation and condensation protein	scpB	-	2.8.1.1,2.8.1.2	ko:K01011,ko:K06024	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000,ko03036	-	-	-	SMC_ScpB
MMS2_k127_2112898_0	273116.14324840	3.446e-127	421.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,241JT@183967|Thermoplasmata	183967|Thermoplasmata	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMS2_k127_2112898_2	768679.TTX_0182	8.106e-59	211.0	COG2220@1|root,arCOG00497@2157|Archaea,2XPSC@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the UPF0173 family	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
MMS2_k127_2112898_1	273116.14324578	3.634e-59	217.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,241RR@183967|Thermoplasmata	183967|Thermoplasmata	J	PFAM elongation factor Tu, domain 2 protein	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
MMS2_k127_2112898_4	263820.PTO0948	8.181e-14	74.0	COG0276@1|root,arCOG05373@2157|Archaea,2XTYB@28890|Euryarchaeota,24260@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
MMS2_k127_21193_1	273116.14325756	2.12e-62	222.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,24250@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	Helicase_C,ResIII
MMS2_k127_21193_0	273116.14325757	1.65e-123	404.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,241K8@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rep_fac_C
MMS2_k127_21193_2	263820.PTO0379	1.406e-52	192.0	COG0299@1|root,arCOG02825@2157|Archaea,2Y838@28890|Euryarchaeota,2427V@183967|Thermoplasmata	183967|Thermoplasmata	F	Formyl transferase	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
MMS2_k127_2119407_6	263820.PTO1165	4.299e-60	214.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7AD@28890|Euryarchaeota,24212@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_21
MMS2_k127_2119407_0	263820.PTO1166	2.296e-157	508.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,241IG@183967|Thermoplasmata	183967|Thermoplasmata	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS2_k127_2119407_5	263820.PTO1167	1.291e-61	218.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,241RQ@183967|Thermoplasmata	183967|Thermoplasmata	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
MMS2_k127_2119407_7	273075.Ta0570	1.327e-30	126.0	COG1936@1|root,arCOG01038@2157|Archaea,2Y662@28890|Euryarchaeota,242EY@183967|Thermoplasmata	183967|Thermoplasmata	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMS2_k127_2119407_3	273116.14324814	7.646e-106	358.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,241M9@183967|Thermoplasmata	183967|Thermoplasmata	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
MMS2_k127_2119407_2	263820.PTO1378	1.208e-109	360.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,241N5@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMS2_k127_2119407_4	263820.PTO1379	1.498e-72	256.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,241R8@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS2_k127_2119407_1	273075.Ta0835	6.256e-115	385.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,241JB@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMS2_k127_2127356_3	273116.14324597	1.795e-08	57.0	arCOG07405@1|root,arCOG07405@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2127356_1	263820.PTO0715	5.127e-85	284.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,241RH@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS2_k127_2127356_0	273116.14324753	2.619e-104	346.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,241N8@183967|Thermoplasmata	183967|Thermoplasmata	E	Arginase family	-	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS2_k127_2127356_2	351160.LRC52	2.568e-32	129.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMS2_k127_2127356_5	749414.SBI_08920	2.9e-06	56.0	COG0601@1|root,COG0601@2|Bacteria,2GJFF@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_2167722_1	1337936.IJ00_20800	3.02e-19	103.0	COG0515@1|root,COG0515@2|Bacteria,1G1J3@1117|Cyanobacteria,1HMEK@1161|Nostocales	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Pkinase
MMS2_k127_2167722_0	537007.BLAHAN_05127	4.854e-33	138.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,3XYRV@572511|Blautia	186801|Clostridia	T	Psort location Cytoplasmic, score 8.87	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
MMS2_k127_217553_0	485918.Cpin_3705	2.749e-11	74.0	COG1215@1|root,COG1215@2|Bacteria,4NEG0@976|Bacteroidetes,1INP1@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
MMS2_k127_217553_1	1382356.JQMP01000003_gene1338	1.093e-05	58.0	COG5650@1|root,COG5650@2|Bacteria,2GB8F@200795|Chloroflexi,27Y1V@189775|Thermomicrobia	189775|Thermomicrobia	S	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2194001_2	273075.Ta0413	2.062e-36	141.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMS2_k127_2194001_3	273116.14325422	2.739e-28	122.0	arCOG03853@1|root,arCOG03853@2157|Archaea,2Y52X@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2194001_1	273075.Ta0468	1.52e-179	572.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,241N0@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMS2_k127_2194001_0	273075.Ta0414	4.97e-223	699.0	COG0493@1|root,arCOG01292@2157|Archaea,2XVPT@28890|Euryarchaeota	28890|Euryarchaeota	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14,1.8.1.19	ko:K00266,ko:K20202	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS2_k127_2194001_4	273116.14324579	4.912e-07	59.0	arCOG07408@1|root,arCOG07408@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2239936_2	1121875.KB907547_gene3294	2.687e-35	147.0	COG0578@1|root,COG0578@2|Bacteria,4PKIZ@976|Bacteroidetes	976|Bacteroidetes	C	Glycerol-3-phosphate dehydrogenase	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
MMS2_k127_2239936_3	273116.14324449	0.0006313	48.0	arCOG03769@1|root,arCOG03769@2157|Archaea	2157|Archaea	M	glucosylceramidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2239936_0	263820.PTO1372	1.655e-85	289.0	COG0819@1|root,arCOG01128@2157|Archaea	2157|Archaea	K	transcription activator	-	-	1.3.3.11	ko:K06137,ko:K20896	ko00730,ko01100,map00730,map01100	-	R09993,R11313	RC00197,RC02832	ko00000,ko00001,ko01000	-	-	-	Haem_oxygenas_2,TENA_THI-4
MMS2_k127_2239936_1	399549.Msed_1522	1.05e-37	145.0	COG0372@1|root,arCOG04237@2157|Archaea,2XPMK@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS2_k127_2258303_1	273075.Ta0158	3.862e-76	261.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,241W3@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
MMS2_k127_2258303_0	273075.Ta0159	8.411e-161	522.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,241YU@183967|Thermoplasmata	183967|Thermoplasmata	L	Type IV secretory system Conjugative DNA transfer	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
MMS2_k127_2258303_2	273116.14324445	2.081e-65	236.0	COG1630@1|root,arCOG00367@2157|Archaea,2Y3KS@28890|Euryarchaeota,2427K@183967|Thermoplasmata	183967|Thermoplasmata	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
MMS2_k127_2263077_6	1280390.CBQR020000025_gene594	1.766e-07	56.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,4HIGT@91061|Bacilli,26WVR@186822|Paenibacillaceae	91061|Bacilli	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
MMS2_k127_2263077_3	264198.Reut_C6210	2.32e-52	199.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2VX9A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Peptidase_S9
MMS2_k127_2263077_2	1408224.SAMCCGM7_c1878	9.584e-54	200.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria	1224|Proteobacteria	K	3-keto-5-aminohexanoate cleavage protein	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
MMS2_k127_2263077_0	985053.VMUT_1229	2.889e-95	320.0	arCOG06505@1|root,arCOG06505@2157|Archaea,2XRQB@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2263077_5	1027292.HMPREF9372_2073	5.06e-24	115.0	COG2271@1|root,COG2271@2|Bacteria,1V0VC@1239|Firmicutes,4HCQG@91061|Bacilli	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_2263077_1	671065.MetMK1DRAFT_00007320	2.455e-79	275.0	COG0111@1|root,arCOG01754@2157|Archaea	2157|Archaea	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_2263077_4	671065.MetMK1DRAFT_00001030	1.071e-43	174.0	COG0477@1|root,arCOG02682@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
MMS2_k127_22643_3	273116.14325304	1.135e-68	244.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,241IU@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMS2_k127_22643_1	933801.Ahos_1338	3.584e-76	268.0	COG0075@1|root,arCOG00082@2157|Archaea,2XQJ2@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMS2_k127_22643_0	273063.STK_12180	6.432e-94	319.0	COG0111@1|root,arCOG01754@2157|Archaea,2XPRE@28889|Crenarchaeota	28889|Crenarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_22643_2	273116.14325205	2.121e-69	245.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUG5@28890|Euryarchaeota,241YW@183967|Thermoplasmata	183967|Thermoplasmata	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_2306655_0	273063.STK_11180	8.793e-200	631.0	COG0044@1|root,arCOG00689@2157|Archaea,2XQ3G@28889|Crenarchaeota	28889|Crenarchaeota	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
MMS2_k127_2306655_2	273116.14325673	1.764e-19	97.0	COG0640@1|root,arCOG01687@2157|Archaea	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
MMS2_k127_2306655_1	1006006.Mcup_0700	4.127e-45	174.0	COG0477@1|root,arCOG00135@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_232603_1	1051632.TPY_3362	6.682e-195	621.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,3WD2K@538999|Clostridiales incertae sedis	186801|Clostridia	C	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative mitochondrial subgroup	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS2_k127_232603_7	273075.Ta0883	1.867e-49	185.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,241UB@183967|Thermoplasmata	183967|Thermoplasmata	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	-	TP_methylase
MMS2_k127_232603_2	273116.14325249	3.633e-151	488.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,241N7@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMS2_k127_232603_5	273116.14325248	4.632e-75	257.0	COG0663@1|root,arCOG01849@2157|Archaea,2XWNM@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
MMS2_k127_232603_6	263820.PTO1237	8.959e-70	246.0	COG0524@1|root,arCOG00014@2157|Archaea,2Y65P@28890|Euryarchaeota,241U0@183967|Thermoplasmata	183967|Thermoplasmata	F	pfkB family carbohydrate kinase	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006213,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008617,GO:0008906,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009129,GO:0009130,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042278,GO:0042455,GO:0043167,GO:0043168,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046033,GO:0046035,GO:0046085,GO:0046087,GO:0046102,GO:0046128,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1905108	2.7.1.213,2.7.1.73	ko:K22026	ko00230,ko00240,map00230,map00240	-	R00513,R01131,R01228	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS2_k127_232603_8	273075.Ta1609	0.0002776	49.0	COG1617@1|root,arCOG02197@2157|Archaea,2Y61S@28890|Euryarchaeota,242G0@183967|Thermoplasmata	183967|Thermoplasmata	S	KEOPS complex Cgi121-like subunit	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	-
MMS2_k127_232603_0	273075.Ta1081	1.391e-307	953.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,241JF@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
MMS2_k127_232603_3	273075.Ta0824	1.479e-122	402.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,241MM@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
MMS2_k127_232603_4	273116.14324767	8.02e-100	342.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2421B@183967|Thermoplasmata	183967|Thermoplasmata	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMS2_k127_2351901_0	273116.14325209	7.599e-106	371.0	COG5650@1|root,arCOG03702@2157|Archaea,2Y3AP@28890|Euryarchaeota,2423M@183967|Thermoplasmata	183967|Thermoplasmata	S	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2353096_0	263820.PTO1191	1.662e-234	749.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,241JC@183967|Thermoplasmata	183967|Thermoplasmata	J	leucyl-tRNA aminoacylation	leuS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_2353096_1	1047013.AQSP01000037_gene1326	2.157e-110	363.0	COG1830@1|root,COG1830@2|Bacteria,2NPYC@2323|unclassified Bacteria	2|Bacteria	G	DeoC/LacD family aldolase	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245,4.1.2.13	ko:K08321,ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMS2_k127_2353185_8	797210.Halxa_0138	4.904e-06	51.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota,23SZN@183963|Halobacteria	183963|Halobacteria	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS2_k127_2353185_2	273116.14324273	7.204e-89	301.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,24210@183967|Thermoplasmata	183967|Thermoplasmata	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
MMS2_k127_2353185_3	273116.14324274	1.913e-54	197.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,24286@183967|Thermoplasmata	183967|Thermoplasmata	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS2_k127_2353185_1	273116.14324343	1.028e-113	382.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,241NJ@183967|Thermoplasmata	183967|Thermoplasmata	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMS2_k127_2353185_5	273116.14324335	4.996e-35	139.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,241TG@183967|Thermoplasmata	183967|Thermoplasmata	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
MMS2_k127_2353185_7	196162.Noca_4890	4.009e-15	80.0	COG0425@1|root,COG0425@2|Bacteria,2GSNH@201174|Actinobacteria	201174|Actinobacteria	O	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
MMS2_k127_2353185_4	632335.Calkr_2020	2.444e-46	173.0	COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,24HGD@186801|Clostridia,42GJQ@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM cyclase family protein	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
MMS2_k127_2353185_0	273075.Ta0429	1.722e-150	494.0	COG2025@1|root,arCOG00448@2157|Archaea,2Y2B4@28890|Euryarchaeota,2424H@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS2_k127_2353185_6	273075.Ta0428	4.419e-32	127.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y7BW@28890|Euryarchaeota,242EM@183967|Thermoplasmata	183967|Thermoplasmata	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS2_k127_2368076_0	273116.14325335	3.901e-117	387.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,241PF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	HD,Trm56
MMS2_k127_2368076_1	273075.Ta0930	2.597e-76	258.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
MMS2_k127_2368076_2	273075.Ta1302	6.105e-41	155.0	arCOG05357@1|root,arCOG05357@2157|Archaea,2Y1B1@28890|Euryarchaeota,242C7@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2420276_0	273116.14325490	2.607e-94	317.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,241UJ@183967|Thermoplasmata	183967|Thermoplasmata	E	lyase activity	-	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0008150,GO:0008152,GO:0008674,GO:0008675,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	4.1.2.51,4.3.3.7	ko:K01714,ko:K18127	ko00030,ko00052,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00052,map00261,map00300,map01100,map01110,map01120,map01130,map01200,map01230	M00016,M00309,M00525,M00526,M00527	R08570,R10147,R10616	RC00307,RC00435,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS2_k127_2420276_2	273075.Ta1116	2.389e-51	184.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,241TC@183967|Thermoplasmata	183967|Thermoplasmata	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMS2_k127_2420276_3	263820.PTO1281	1.307e-28	115.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,241VA@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMS2_k127_2420276_5	263820.PTO1282	1.155e-20	92.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,241X3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMS2_k127_2420276_1	273116.14324665	3.015e-52	189.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,241SJ@183967|Thermoplasmata	183967|Thermoplasmata	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMS2_k127_2420276_4	263820.PTO1284	3.151e-28	115.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,241KA@183967|Thermoplasmata	183967|Thermoplasmata	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
MMS2_k127_2424520_1	263820.PTO0700	3.233e-94	319.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,241UT@183967|Thermoplasmata	183967|Thermoplasmata	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2424520_2	263820.PTO0210	1.948e-64	228.0	COG0284@1|root,arCOG00081@2157|Archaea,2XU66@28890|Euryarchaeota,241PX@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
MMS2_k127_2424520_0	273116.14324241	8.063e-110	367.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,242FP@183967|Thermoplasmata	183967|Thermoplasmata	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS2_k127_2435706_2	263820.PTO1158	7.193e-18	83.0	arCOG05387@1|root,arCOG05387@2157|Archaea,2Y1EF@28890|Euryarchaeota,242GU@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2435706_3	273075.Ta1317	1.691e-17	90.0	arCOG05382@1|root,arCOG05382@2157|Archaea,2Y5Z0@28890|Euryarchaeota,242HQ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2435706_1	671065.MetMK1DRAFT_00019250	3.885e-29	119.0	COG1733@1|root,arCOG01057@2157|Archaea,2XSCC@28889|Crenarchaeota	28889|Crenarchaeota	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS2_k127_2435706_0	386043.lwe0754	9.241e-46	171.0	COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli,26JPA@186820|Listeriaceae	91061|Bacilli	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
MMS2_k127_2435706_4	263820.PTO1489	5.036e-05	45.0	COG1506@1|root,arCOG01646@2157|Archaea,2XU9I@28890|Euryarchaeota,2422H@183967|Thermoplasmata	183967|Thermoplasmata	E	Prolyl oligopeptidase family	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9
MMS2_k127_2437065_2	292459.STH3016	5.143e-83	280.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia	186801|Clostridia	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS2_k127_2437065_5	224325.AF_0483	8.588e-07	53.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y130@28890|Euryarchaeota,246GP@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2437065_3	42256.RradSPS_2260	8.047e-39	153.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4CQ98@84995|Rubrobacteria	84995|Rubrobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
MMS2_k127_2437065_0	330779.Saci_1769	2.675e-142	467.0	COG3511@1|root,arCOG05966@2157|Archaea,2XRK9@28889|Crenarchaeota	2157|Archaea	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
MMS2_k127_2437065_1	263820.PTO0976	1.474e-122	413.0	COG1132@1|root,arCOG02841@2157|Archaea,2XSW0@28890|Euryarchaeota,2426N@183967|Thermoplasmata	183967|Thermoplasmata	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_2437065_4	309799.DICTH_0477	1.858e-38	149.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	yfiB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_2440133_1	273116.14324741	4.841e-29	118.0	COG0842@1|root,arCOG01469@2157|Archaea,2Y1TJ@28890|Euryarchaeota,2420B@183967|Thermoplasmata	183967|Thermoplasmata	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_2440133_2	765177.Desmu_0521	0.0003039	53.0	COG1277@1|root,arCOG02441@2157|Archaea,2XQE4@28889|Crenarchaeota	28889|Crenarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_2440133_0	591019.Shell_0704	1.143e-47	177.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_2445142_0	273075.Ta0974	2.569e-174	553.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,2425E@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_2445142_3	273116.14325381	4.581e-52	194.0	COG1801@1|root,arCOG04291@2157|Archaea,2XY6C@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS2_k127_2445142_2	273116.14325380	3.38e-92	318.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,241SW@183967|Thermoplasmata	183967|Thermoplasmata	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMS2_k127_2445142_1	273116.14325379	1.505e-158	519.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,241KN@183967|Thermoplasmata	183967|Thermoplasmata	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GatB_N
MMS2_k127_2445142_4	263820.PTO1400	9.739e-46	169.0	COG0838@1|root,arCOG01557@2157|Archaea,2Y7BF@28890|Euryarchaeota,242B8@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
MMS2_k127_2445142_5	273075.Ta0969m	7.668e-09	58.0	COG0377@1|root,arCOG01554@2157|Archaea,2XTP1@28890|Euryarchaeota,241SV@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.5.98.3,1.6.5.3	ko:K00331,ko:K22159	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Oxidored_q6
MMS2_k127_2453937_2	263820.PTO0414	2.576e-61	220.0	COG3885@1|root,arCOG01729@2157|Archaea,2XYMU@28890|Euryarchaeota,2428X@183967|Thermoplasmata	183967|Thermoplasmata	Q	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
MMS2_k127_2453937_0	273075.Ta0444	2.772e-232	723.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,241IH@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMS2_k127_2453937_3	273116.14325316	6.963e-57	198.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,241R0@183967|Thermoplasmata	183967|Thermoplasmata	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMS2_k127_2453937_1	273116.14325315	7.164e-198	621.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,241J6@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS2_k127_2459969_0	263820.PTO1250	2.528e-42	179.0	arCOG05397@1|root,arCOG05397@2157|Archaea,2Y4YZ@28890|Euryarchaeota,242E9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2459969_1	273075.Ta1101	1.383e-38	149.0	arCOG05327@1|root,arCOG05327@2157|Archaea,2Y236@28890|Euryarchaeota,2429B@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2462127_1	263820.PTO0105	3.257e-81	284.0	COG1228@1|root,arCOG00696@2157|Archaea,2XUHH@28890|Euryarchaeota,241YC@183967|Thermoplasmata	183967|Thermoplasmata	F	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS2_k127_2462127_0	263820.PTO0430	8.498e-111	366.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,241PJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative diphthamide synthesis protein	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMS2_k127_247072_0	290399.Arth_1860	1.523e-23	112.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	afr	-	1.1.1.292	ko:K19181	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS2_k127_247072_1	1033806.HTIA_0406	3.329e-05	51.0	arCOG04567@1|root,arCOG04567@2157|Archaea,2XWK3@28890|Euryarchaeota,23VF6@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2473162_1	273116.14325758	3.06e-218	683.0	COG0174@1|root,arCOG01909@2157|Archaea,2XSYS@28890|Euryarchaeota,241WU@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
MMS2_k127_2473162_3	273116.14324604	2.443e-60	221.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,241RN@183967|Thermoplasmata	183967|Thermoplasmata	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
MMS2_k127_2473162_0	273116.14324403	0.0	1062.0	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,241JD@183967|Thermoplasmata	183967|Thermoplasmata	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMS2_k127_2473162_2	273075.Ta0085m	2.08e-183	582.0	COG4948@1|root,arCOG01168@2157|Archaea,2XTSG@28890|Euryarchaeota,24211@183967|Thermoplasmata	183967|Thermoplasmata	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0003674,GO:0003824,GO:0008869,GO:0016829,GO:0016835,GO:0016836,GO:0047929	4.2.1.140	ko:K05308	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00308,M00309,M00633	R01538,R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS2_k127_2473162_4	273075.Ta0084	6.134e-21	104.0	COG0467@1|root,arCOG01693@2157|Archaea	2157|Archaea	T	V4R	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	ATPase,V4R
MMS2_k127_2473162_5	579137.Metvu_1665	1.813e-12	72.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,23QZC@183939|Methanococci	183939|Methanococci	K	transcriptional regulatory protein	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
MMS2_k127_2485593_6	224324.aq_2181	6.38e-28	118.0	COG0314@1|root,COG0314@2|Bacteria,2G551@200783|Aquificae	200783|Aquificae	H	molybdopterin	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
MMS2_k127_2485593_3	273075.Ta1368m	1.619e-62	218.0	COG1225@1|root,arCOG00310@2157|Archaea,2XXB2@28890|Euryarchaeota,2427J@183967|Thermoplasmata	183967|Thermoplasmata	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS2_k127_2485593_4	273116.14325268	1.784e-59	213.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,241U3@183967|Thermoplasmata	183967|Thermoplasmata	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMS2_k127_2485593_1	673860.AciM339_0294	3.182e-111	369.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_2485593_5	263820.PTO0817	1.336e-39	154.0	arCOG03379@1|root,arCOG03379@2157|Archaea,2XZH1@28890|Euryarchaeota,241W9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2485593_0	273116.14325266	5.678e-138	452.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,241KV@183967|Thermoplasmata	183967|Thermoplasmata	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMS2_k127_2485593_7	273075.Ta0167	9.685e-15	89.0	arCOG03675@1|root,arCOG03675@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Thermopsin
MMS2_k127_2485593_2	273116.14325200	6.769e-90	310.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7A9@28890|Euryarchaeota,2420I@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3
MMS2_k127_250052_2	263820.PTO0862	8.538e-55	200.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,24243@183967|Thermoplasmata	183967|Thermoplasmata	E	Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids	trf2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS2_k127_250052_0	263820.PTO0550	6.554e-119	388.0	COG0320@1|root,arCOG00660@2157|Archaea,2XUQB@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMS2_k127_250052_1	273116.14324315	6.142e-76	258.0	COG1071@1|root,arCOG01054@2157|Archaea,2XUGH@28890|Euryarchaeota,24218@183967|Thermoplasmata	183967|Thermoplasmata	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMS2_k127_2518546_1	273116.14325548	1.037e-12	70.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y10D@28890|Euryarchaeota,242AI@183967|Thermoplasmata	183967|Thermoplasmata	S	ribosomal small subunit binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2518546_0	273116.14325549	9.369e-60	214.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,241RE@183967|Thermoplasmata	183967|Thermoplasmata	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMS2_k127_2518546_2	768679.TTX_0279	1.487e-09	70.0	arCOG07425@1|root,arCOG07425@2157|Archaea	2157|Archaea	KLT	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD,Pkinase,Transglut_core
MMS2_k127_2524696_1	273075.Ta1319	3.688e-88	299.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,241MY@183967|Thermoplasmata	183967|Thermoplasmata	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS2_k127_2524696_2	273075.Ta1359	5.557e-59	211.0	COG0602@1|root,arCOG02173@2157|Archaea,2XUSP@28890|Euryarchaeota,241VU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_2524696_0	263820.PTO0981	2.675e-141	456.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTI9@28890|Euryarchaeota,241MH@183967|Thermoplasmata	183967|Thermoplasmata	E	Metallopeptidase family M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
MMS2_k127_2524696_3	273116.14324771	9.039e-54	201.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,241UK@183967|Thermoplasmata	183967|Thermoplasmata	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMS2_k127_2524696_5	273075.Ta1039	2.269e-20	95.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y5W9@28890|Euryarchaeota,242GT@183967|Thermoplasmata	183967|Thermoplasmata	U	SRP19 protein	-	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
MMS2_k127_2524696_4	263820.PTO0984	6.119e-39	148.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,241T7@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMS2_k127_2526536_5	273116.14324585	1.267e-58	208.0	COG0723@1|root,arCOG01720@2157|Archaea	2157|Archaea	C	PFAM Rieske 2Fe-2S domain	soxL	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS2_k127_2526536_1	273075.Ta1228	1.2e-130	436.0	COG1290@1|root,arCOG01721@2157|Archaea,2XVE0@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1290 Cytochrome b subunit of the bc complex	petB2	-	-	ko:K15879	-	-	-	-	ko00000	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS2_k127_2526536_7	999630.TUZN_2081	2.166e-14	82.0	COG1024@1|root,arCOG00239@2157|Archaea	2157|Archaea	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS2_k127_2526536_4	263820.PTO0280	7.536e-59	212.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,241UU@183967|Thermoplasmata	183967|Thermoplasmata	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
MMS2_k127_2526536_0	273116.14325265	1.355e-142	459.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,241JV@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ,ThiG
MMS2_k127_2526536_2	273116.14325418	7.391e-108	359.0	COG0730@1|root,arCOG02050@2157|Archaea,2XYUE@28890|Euryarchaeota,241RV@183967|Thermoplasmata	183967|Thermoplasmata	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS2_k127_2526536_6	263820.PTO1247	4.523e-17	85.0	COG4272@1|root,arCOG05396@2157|Archaea,2Y4XV@28890|Euryarchaeota,242DN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1634)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
MMS2_k127_2526536_3	743719.PaelaDRAFT_1328	4.41e-104	344.0	COG1028@1|root,COG1028@2|Bacteria,1VREU@1239|Firmicutes,4HUY2@91061|Bacilli,26WDM@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS2_k127_2547522_0	273116.14324628	2.527e-69	239.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,241MC@183967|Thermoplasmata	183967|Thermoplasmata	J	translation initiation factor 2 subunit alpha	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMS2_k127_2547522_3	273075.Ta1204	1.926e-16	80.0	COG2051@1|root,arCOG04108@2157|Archaea,2Y6HD@28890|Euryarchaeota,241W8@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMS2_k127_2547522_1	263820.PTO0407	3.338e-43	158.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,241RG@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMS2_k127_2547522_2	1391646.AVSU01000118_gene1348	5.406e-38	147.0	COG2897@1|root,COG2897@2|Bacteria,1TRYA@1239|Firmicutes,24GYI@186801|Clostridia,25S7J@186804|Peptostreptococcaceae	186801|Clostridia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
MMS2_k127_2573772_1	1229909.NSED_01010	3.595e-63	226.0	COG1801@1|root,arCOG04291@2157|Archaea,41T6J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS2_k127_2573772_3	1122221.JHVI01000020_gene1120	8.344e-24	106.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
MMS2_k127_2573772_2	591019.Shell_0393	3.867e-24	110.0	COG2013@1|root,arCOG01907@2157|Archaea,2XQ76@28889|Crenarchaeota	28889|Crenarchaeota	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
MMS2_k127_2573772_4	1205910.B005_5413	3.78e-20	94.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria	201174|Actinobacteria	IQ	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
MMS2_k127_2573772_0	33876.JNXY01000045_gene1934	2.758e-66	236.0	COG0596@1|root,COG0596@2|Bacteria,2IFCI@201174|Actinobacteria,4DC31@85008|Micromonosporales	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS2_k127_258275_1	263820.PTO1483	1.362e-52	196.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota	28890|Euryarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
MMS2_k127_258275_0	768679.TTX_0809	1.189e-57	214.0	COG1748@1|root,arCOG00243@2157|Archaea,2XQJJ@28889|Crenarchaeota	28889|Crenarchaeota	C	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Semialdhyde_dh,UDPG_MGDP_dh_N
MMS2_k127_2597822_0	397948.Cmaq_1232	1.466e-104	350.0	COG2377@1|root,2N56F@2157|Archaea	2157|Archaea	O	Anhydro-N-acetylmuramic acid kinase	-	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
MMS2_k127_2597822_4	28444.JODQ01000007_gene5149	2.229e-17	96.0	COG0747@1|root,COG0747@2|Bacteria,2IA6M@201174|Actinobacteria,4EKPC@85012|Streptosporangiales	201174|Actinobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_2597822_2	525909.Afer_0172	8.793e-75	263.0	COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4CNNT@84992|Acidimicrobiia	84992|Acidimicrobiia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_2597822_3	324057.Pjdr2_4154	4.43e-65	233.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HA7I@91061|Bacilli,26QGW@186822|Paenibacillaceae	91061|Bacilli	P	Peptide ABC transporter permease	oppC1	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_2597822_1	479432.Sros_7459	2.493e-77	270.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4EFUM@85012|Streptosporangiales	201174|Actinobacteria	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_2614941_2	273057.SSO3115	1.42e-46	173.0	COG0596@1|root,arCOG01648@2157|Archaea	2157|Archaea	IQ	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
MMS2_k127_2614941_3	935836.JAEL01000053_gene4879	6.089e-24	109.0	COG1443@1|root,COG1443@2|Bacteria,1V6SB@1239|Firmicutes,4HJ2T@91061|Bacilli,1ZFNY@1386|Bacillus	91061|Bacilli	I	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	M1-740	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS2_k127_2614941_1	436308.Nmar_1567	2.032e-51	192.0	COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydratase	-	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
MMS2_k127_2614941_0	263820.PTO1091	6.533e-124	402.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,241PI@183967|Thermoplasmata	183967|Thermoplasmata	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS2_k127_2628436_0	273116.14325312	1.992e-161	531.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
MMS2_k127_2628436_1	273116.14325311	2.666e-69	247.0	COG1474@1|root,arCOG00467@2157|Archaea,2Y0SQ@28890|Euryarchaeota,242CI@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22
MMS2_k127_2646726_1	273116.14324742	4.976e-14	74.0	COG1131@1|root,arCOG00194@2157|Archaea,2Y39V@28890|Euryarchaeota,2422I@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_2646726_0	351160.RCIX195	1.885e-15	81.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUUY@28890|Euryarchaeota,2N99V@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_2674344_0	263820.PTO0625	2.513e-53	194.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,241TF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMS2_k127_2674344_1	263820.PTO0624	2.284e-44	164.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,242A6@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS2_k127_2674344_2	933801.Ahos_1240	1.16e-16	87.0	COG1514@1|root,arCOG01736@2157|Archaea,2XQM6@28889|Crenarchaeota	28889|Crenarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS2_k127_2674344_3	273075.Ta0020a	5.859e-07	51.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y4MS@28890|Euryarchaeota,242C9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2686608_11	273075.Ta0165	8.326e-05	45.0	arCOG05360@1|root,arCOG05360@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2686608_7	273075.Ta0166	1.346e-58	211.0	arCOG02274@1|root,arCOG02274@2157|Archaea,2XVHG@28890|Euryarchaeota	28890|Euryarchaeota	K	DNA binding protein	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS2_k127_2686608_2	273075.Ta0646	1.203e-163	531.0	COG1960@1|root,arCOG04100@2157|Archaea,2XTBC@28890|Euryarchaeota,2422U@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
MMS2_k127_2686608_9	1051632.TPY_0769	2.77e-27	123.0	COG3837@1|root,COG3837@2|Bacteria,1V9M6@1239|Firmicutes,24HEN@186801|Clostridia	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS2_k127_2686608_4	273116.14325220	6.046e-98	333.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,241PQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS2_k127_2686608_8	273116.14325221	9.014e-40	157.0	COG0388@1|root,arCOG00062@2157|Archaea,2Y3PB@28890|Euryarchaeota,24280@183967|Thermoplasmata	183967|Thermoplasmata	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
MMS2_k127_2686608_6	273075.Ta0887	7.975e-61	218.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y72P@28890|Euryarchaeota,2428V@183967|Thermoplasmata	183967|Thermoplasmata	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS2_k127_2686608_0	273116.14325244	0.0	1197.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,241RC@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS2_k127_2686608_1	273075.Ta1199	1.096e-229	719.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,241S4@183967|Thermoplasmata	183967|Thermoplasmata	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
MMS2_k127_2686608_3	273075.Ta1198	4.12e-98	327.0	COG0382@1|root,arCOG00477@2157|Archaea,2XW9S@28890|Euryarchaeota,24265@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
MMS2_k127_2686608_5	273116.14324471	1.445e-94	325.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS2_k127_2686608_10	263820.PTO1352	5.552e-21	94.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7A1@28890|Euryarchaeota,241YY@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_2731097_2	263820.PTO0468	2.728e-36	139.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,241K3@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_2731097_1	263820.PTO0526	4.048e-37	142.0	arCOG02738@1|root,arCOG02738@2157|Archaea,2Y4Q5@28890|Euryarchaeota,242E8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2731097_3	263820.PTO0905	3.348e-35	141.0	COG1628@1|root,arCOG00928@2157|Archaea,2Y65C@28890|Euryarchaeota,242EF@183967|Thermoplasmata	183967|Thermoplasmata	L	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
MMS2_k127_2731097_0	1343739.PAP_01865	1.153e-122	408.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	pdhD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4,1.8.1.7	ko:K00382,ko:K00383	ko00010,ko00020,ko00260,ko00280,ko00480,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04918,map00010,map00020,map00260,map00280,map00480,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04918	M00009,M00011,M00036,M00307,M00532	R00094,R00115,R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00011,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A3561	Pyr_redox_2,Pyr_redox_dim
MMS2_k127_2731097_4	485913.Krac_1566	8.243e-35	144.0	COG3177@1|root,COG3177@2|Bacteria,2G7KD@200795|Chloroflexi	200795|Chloroflexi	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
MMS2_k127_2740444_1	273063.STK_26120	1.93e-17	93.0	COG0454@1|root,arCOG00826@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,Acetyltransf_9
MMS2_k127_2745712_0	263820.PTO0802	8.889e-94	320.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,241NB@183967|Thermoplasmata	183967|Thermoplasmata	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMS2_k127_2831033_0	273075.Ta1064	6.219e-74	254.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,241PC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_Crp_2
MMS2_k127_2831033_2	273116.14324735	2.096e-11	68.0	arCOG05391@1|root,arCOG05391@2157|Archaea,2Y53B@28890|Euryarchaeota,242H4@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2831033_1	930945.SiRe_2499	3.002e-29	123.0	COG5424@1|root,arCOG06031@2157|Archaea,2XRWB@28889|Crenarchaeota	28889|Crenarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4,zf-C2H2_9
MMS2_k127_2886693_5	1042877.GQS_04200	1.751e-24	109.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota,2443S@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2886693_1	273116.14325130	1.624e-133	443.0	COG0405@1|root,arCOG04053@2157|Archaea,2XUEX@28890|Euryarchaeota,2422W@183967|Thermoplasmata	183967|Thermoplasmata	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
MMS2_k127_2886693_0	263820.PTO0683	2.123e-150	501.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,24242@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K00400,ko:K02031,ko:K02032	ko00680,ko01100,ko01120,ko02024,map00680,map01100,map01120,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_2886693_3	44251.PDUR_01435	6.465e-59	215.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26Q9W@186822|Paenibacillaceae	91061|Bacilli	EP	ABC transporter permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_2886693_2	1501230.ET33_06925	5.869e-87	298.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,26RTC@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_2886693_4	439481.Aboo_1255	8.275e-50	198.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F353@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_2898848_9	273075.Ta0309	4.006e-10	61.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,241JR@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMS2_k127_2898848_5	273075.Ta0548m	7.72e-43	160.0	arCOG05362@1|root,arCOG05362@2157|Archaea,2Y5IA@28890|Euryarchaeota,242EZ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2898848_8	263820.PTO1275	5.54e-30	125.0	arCOG05401@1|root,arCOG05401@2157|Archaea,2Y42P@28890|Euryarchaeota,242AN@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2898848_7	273116.14324875	9.417e-31	130.0	COG0417@1|root,arCOG00328@2157|Archaea	273116.14324875|-	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2898848_6	273075.Ta0611	2.37e-40	153.0	COG0517@1|root,arCOG00606@2157|Archaea,2Y0BC@28890|Euryarchaeota,242A4@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_2898848_3	273116.14324878	5.916e-84	283.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,241Q3@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMS2_k127_2898848_0	263820.PTO0687	7.799e-316	976.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,241KZ@183967|Thermoplasmata	183967|Thermoplasmata	S	KH domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
MMS2_k127_2898848_4	1304875.JAFZ01000001_gene1332	4.984e-60	214.0	COG0176@1|root,COG0176@2|Bacteria,3TA7M@508458|Synergistetes	508458|Synergistetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
MMS2_k127_2898848_1	273075.Ta0617	1.661e-134	435.0	COG3958@1|root,arCOG01051@2157|Archaea,2Y86K@28890|Euryarchaeota,241IF@183967|Thermoplasmata	183967|Thermoplasmata	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS2_k127_2898848_2	273075.Ta0618	5.198e-105	346.0	COG3959@1|root,arCOG01053@2157|Archaea,2XT88@28890|Euryarchaeota,241MN@183967|Thermoplasmata	183967|Thermoplasmata	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS2_k127_2900857_3	189753.AXAS01000002_gene5413	3.953e-31	134.0	COG3391@1|root,COG3391@2|Bacteria,1RFWG@1224|Proteobacteria,2U7T8@28211|Alphaproteobacteria,3K2MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2900857_0	273116.14325461	1.727e-47	175.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Chromate resistance	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
MMS2_k127_2900857_4	1267535.KB906767_gene4696	1.292e-26	117.0	COG2020@1|root,COG2020@2|Bacteria,3Y55R@57723|Acidobacteria,2JJVJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
MMS2_k127_2900857_5	675635.Psed_4948	0.0002396	53.0	COG3832@1|root,COG3832@2|Bacteria,2GWXS@201174|Actinobacteria	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS2_k127_2900857_2	1169152.AXVD01000023_gene3257	6.639e-32	138.0	COG0477@1|root,COG0500@1|root,COG0477@2|Bacteria,COG2226@2|Bacteria,2HHY4@201174|Actinobacteria,4G1MV@85025|Nocardiaceae	201174|Actinobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_2900857_1	1417296.U879_03690	2.964e-37	143.0	COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,2USUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,Fer4
MMS2_k127_2916534_4	671065.MetMK1DRAFT_00005900	2.668e-15	85.0	arCOG03768@1|root,arCOG03768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF973
MMS2_k127_2916534_3	263820.PTO0821	3.766e-36	142.0	COG0589@1|root,arCOG02053@2157|Archaea,2Y1KW@28890|Euryarchaeota,242E4@183967|Thermoplasmata	183967|Thermoplasmata	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
MMS2_k127_2916534_5	263820.PTO0820	3.576e-15	77.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y7C3@28890|Euryarchaeota,242FZ@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
MMS2_k127_2916534_0	273075.Ta0582	6.289e-159	510.0	COG0183@1|root,arCOG01282@2157|Archaea,2XT8C@28890|Euryarchaeota,241KE@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_2916534_1	273075.Ta0061	6.782e-58	209.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,2428Q@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS2_k127_2916534_2	547144.HydHO_0231	7.595e-54	203.0	COG0031@1|root,COG0031@2|Bacteria,2G3Z0@200783|Aquificae	200783|Aquificae	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47	ko:K01738,ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_292578_1	273075.Ta0110	6.25e-70	243.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2423S@183967|Thermoplasmata	183967|Thermoplasmata	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMS2_k127_292578_3	263820.PTO0567	6.329e-15	84.0	arCOG07356@1|root,arCOG07356@2157|Archaea,2Y629@28890|Euryarchaeota,242F0@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_292578_0	263820.PTO1105	1.663e-75	258.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
MMS2_k127_292578_2	673860.AciM339_1212	2.124e-17	85.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,3F2PX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMS2_k127_2948385_1	387631.Asulf_01198	1.787e-116	381.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS2_k127_2948385_0	224325.AF_1191	1.738e-118	387.0	COG0447@1|root,arCOG00240@2157|Archaea,2XT32@28890|Euryarchaeota,247I7@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
MMS2_k127_2948385_2	768679.TTX_0394	3.331e-20	93.0	COG3370@1|root,arCOG01668@2157|Archaea	2157|Archaea	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS2_k127_3000107_1	273075.Ta0343	1.173e-106	354.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.20	ko:K01784,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
MMS2_k127_3000107_0	273116.14325123	1.445e-108	361.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7BC@28890|Euryarchaeota,242B5@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_3000107_2	273075.Ta0854	7.778e-62	218.0	COG0279@1|root,arCOG05355@2157|Archaea,2XUSN@28890|Euryarchaeota,241VQ@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
MMS2_k127_3000107_3	747365.Thena_1261	1.509e-27	115.0	COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,24E0T@186801|Clostridia,42IZU@68295|Thermoanaerobacterales	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.3.5.4	ko:K00244,ko:K13796	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
MMS2_k127_3002310_1	273075.Ta1155	6.127e-44	164.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,241Q1@183967|Thermoplasmata	183967|Thermoplasmata	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMS2_k127_3002310_2	273075.Ta0598m	2.1e-41	157.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y6CE@28890|Euryarchaeota,241VF@183967|Thermoplasmata	183967|Thermoplasmata	F	dUTPase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
MMS2_k127_3002310_0	263820.PTO0131	6.074e-97	332.0	COG1457@1|root,arCOG03447@2157|Archaea,2Y0SR@28890|Euryarchaeota,24241@183967|Thermoplasmata	183967|Thermoplasmata	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
MMS2_k127_3002310_3	263820.PTO0333	9.63e-12	80.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2Y65W@28890|Euryarchaeota,242AM@183967|Thermoplasmata	183967|Thermoplasmata	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3016613_9	572478.Vdis_0586	0.0005123	43.0	COG0026@1|root,arCOG01597@2157|Archaea,2XRR5@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
MMS2_k127_3016613_1	273116.14324257	5.588e-62	220.0	COG0457@1|root,arCOG03032@2157|Archaea,2Y7M7@28890|Euryarchaeota,2427N@183967|Thermoplasmata	183967|Thermoplasmata	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
MMS2_k127_3016613_3	273116.14324349	3.791e-50	186.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,241S2@183967|Thermoplasmata	183967|Thermoplasmata	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
MMS2_k127_3016613_0	263820.PTO0201	7.476e-91	305.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,2424W@183967|Thermoplasmata	183967|Thermoplasmata	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_3016613_6	263820.PTO0202	1.099e-34	151.0	COG3368@1|root,arCOG02444@2157|Archaea,2Y68C@28890|Euryarchaeota,2428U@183967|Thermoplasmata	183967|Thermoplasmata	S	Membrane protein of 12 TMs	-	-	-	ko:K07087	-	-	-	-	ko00000	-	-	-	12TM_1
MMS2_k127_3016613_4	263820.PTO0203	1.12e-47	175.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,241U2@183967|Thermoplasmata	183967|Thermoplasmata	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMS2_k127_3016613_5	273116.14324222	3.231e-35	137.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,241XG@183967|Thermoplasmata	183967|Thermoplasmata	S	DNA binding	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
MMS2_k127_3016613_8	273116.14324223	1.353e-19	91.0	COG2167@1|root,arCOG04177@2157|Archaea,2Y6WV@28890|Euryarchaeota,241X6@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	-	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMS2_k127_3016613_7	263820.PTO0206	9.897e-26	108.0	COG2097@1|root,arCOG04473@2157|Archaea,2Y6GN@28890|Euryarchaeota,241W2@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
MMS2_k127_3016613_2	263820.PTO0207	5.308e-60	214.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,241S3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMS2_k127_3025312_0	1196031.ALEG01000046_gene4577	5.348e-47	177.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli,1ZAYW@1386|Bacillus	91061|Bacilli	V	COG1131 ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990,ko:K11050	ko02010,map02010	M00254,M00298	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.130	-	-	ABC_tran
MMS2_k127_3025312_1	443143.GM18_2743	3.781e-45	177.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS2_k127_3064343_1	273116.14325189	4.732e-62	220.0	COG1064@1|root,arCOG01455@2157|Archaea,2XT0X@28890|Euryarchaeota,241ZZ@183967|Thermoplasmata	183967|Thermoplasmata	C	Zinc-binding dehydrogenase	-	-	1.3.1.84	ko:K15020	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00375	R00919	RC00095	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS2_k127_3064343_2	273075.Ta1007	4.087e-39	154.0	arCOG01916@1|root,arCOG01916@2157|Archaea,2Y4Q0@28890|Euryarchaeota,242BX@183967|Thermoplasmata	183967|Thermoplasmata	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
MMS2_k127_3064343_0	273116.14324884	2.08e-74	259.0	COG0329@1|root,arCOG04172@2157|Archaea,2Y2YX@28890|Euryarchaeota,2425H@183967|Thermoplasmata	183967|Thermoplasmata	E	Dihydrodipicolinate synthetase family	-	-	4.1.2.55	ko:K11395	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00309,M00633	R01064,R05605,R08570,R10616	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS2_k127_3067299_2	1501230.ET33_13445	2.171e-24	106.0	COG1670@1|root,COG1670@2|Bacteria,1V63R@1239|Firmicutes,4HIF9@91061|Bacilli,26X04@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_3067299_1	985053.VMUT_1872	7.184e-33	135.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_3067299_0	264462.Bd3186	2.106e-44	167.0	COG0500@1|root,COG0500@2|Bacteria,1QY2M@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_3070391_0	263820.PTO1093	9.99e-55	200.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota,241ZX@183967|Thermoplasmata	183967|Thermoplasmata	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
MMS2_k127_3070391_1	273116.14325049	4.646e-48	187.0	COG0750@1|root,arCOG00609@2157|Archaea,2Y3DV@28890|Euryarchaeota,2425X@183967|Thermoplasmata	183967|Thermoplasmata	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3072813_2	263820.PTO1148	1.854e-44	168.0	COG1321@1|root,arCOG02099@2157|Archaea,2Y7CA@28890|Euryarchaeota,242GR@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
MMS2_k127_3072813_3	416591.Tlet_0840	1.696e-20	97.0	COG1853@1|root,COG1853@2|Bacteria,2GE3B@200918|Thermotogae	200918|Thermotogae	S	PFAM flavin reductase domain protein FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
MMS2_k127_3072813_0	273075.Ta0151m	3.166e-78	270.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y79C@28890|Euryarchaeota,241T8@183967|Thermoplasmata	183967|Thermoplasmata	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS2_k127_3072813_8	263820.PTO0921	0.000233	51.0	COG3432@1|root,arCOG01063@2157|Archaea	2157|Archaea	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
MMS2_k127_3072813_1	431943.CKL_1351	1.741e-70	244.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,36DJ4@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS2_k127_3103103_4	247156.PNF1_610	2.733e-09	67.0	COG0428@1|root,COG0428@2|Bacteria,2ICIQ@201174|Actinobacteria,4FY5S@85025|Nocardiaceae	201174|Actinobacteria	P	Mediates zinc uptake. May also transport other divalent cations	zupT	-	-	-	-	-	-	-	-	-	-	-	Zip
MMS2_k127_3103103_0	263820.PTO0127	2.137e-82	288.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7A7@28890|Euryarchaeota,241ZW@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_3103103_3	1006006.Mcup_1637	1.99e-13	74.0	COG3370@1|root,arCOG01668@2157|Archaea,2XS6U@28889|Crenarchaeota	28889|Crenarchaeota	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS2_k127_3103103_1	273075.Ta1149	1.913e-51	187.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS2_k127_3103103_2	273116.14325499	8.676e-33	129.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,241JJ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMS2_k127_3105476_0	273116.14324436	4.477e-85	290.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y79C@28890|Euryarchaeota,241T8@183967|Thermoplasmata	183967|Thermoplasmata	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS2_k127_3105476_2	263820.PTO0348	1.151e-10	65.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,241RE@183967|Thermoplasmata	183967|Thermoplasmata	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMS2_k127_3122409_3	673860.AciM339_1207	2.328e-13	72.0	COG1873@1|root,arCOG02155@2157|Archaea,2Y75G@28890|Euryarchaeota,3F3FD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS2_k127_3122409_1	273116.14324803	1.117e-179	571.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,241JX@183967|Thermoplasmata	183967|Thermoplasmata	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS2_k127_3122409_2	263820.PTO1444	2.11e-65	230.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,241S5@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS2_k127_3122409_0	273116.14325060	0.0	1138.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,241IC@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_3141293_8	273075.Ta0230	2.719e-12	67.0	COG1960@1|root,arCOG01707@2157|Archaea,2XSVA@28890|Euryarchaeota,2421G@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_3141293_2	263820.PTO1421	4.05e-45	176.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,241U8@183967|Thermoplasmata	183967|Thermoplasmata	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMS2_k127_3141293_0	273116.14324691	3.897e-109	364.0	COG2235@1|root,arCOG03108@2157|Archaea,2XX08@28890|Euryarchaeota,241XU@183967|Thermoplasmata	183967|Thermoplasmata	E	Amidinotransferase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
MMS2_k127_3141293_7	263820.PTO1508	1.044e-14	81.0	COG1975@1|root,arCOG01929@2157|Archaea	2157|Archaea	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
MMS2_k127_3141293_5	744980.TRICHSKD4_1457	3.768e-29	124.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	Molybdopterin	MA20_09420	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,NTP_transf_3
MMS2_k127_3141293_3	273116.14324976	1.969e-42	160.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,242AU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
MMS2_k127_3141293_4	263820.PTO1060	2.466e-36	143.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,242AQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Probable molybdopterin binding domain	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
MMS2_k127_3141293_1	273116.14325188	8.39e-53	194.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,24282@183967|Thermoplasmata	183967|Thermoplasmata	H	ThiF family	-	-	2.7.7.80	ko:K21029,ko:K22132	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiF
MMS2_k127_3141293_9	604354.TSIB_1854	8.008e-12	68.0	COG1977@1|root,arCOG00536@2157|Archaea,2XZ69@28890|Euryarchaeota,244I1@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
MMS2_k127_3141293_6	439481.Aboo_1203	1.102e-23	104.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,3F33B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
MMS2_k127_3155880_5	263820.PTO1104	9.456e-32	125.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,241V9@183967|Thermoplasmata	183967|Thermoplasmata	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMS2_k127_3155880_6	263820.PTO1103	1.208e-31	129.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,241UF@183967|Thermoplasmata	183967|Thermoplasmata	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMS2_k127_3155880_0	263820.PTO0247	1.755e-135	437.0	COG1619@1|root,arCOG04676@2157|Archaea,2Y78V@28890|Euryarchaeota,2420J@183967|Thermoplasmata	183967|Thermoplasmata	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
MMS2_k127_3155880_2	263820.PTO0246	2.327e-131	429.0	COG1473@1|root,arCOG01108@2157|Archaea,2XUUS@28890|Euryarchaeota,2423B@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
MMS2_k127_3155880_1	273075.Ta0080	9.862e-132	430.0	COG0626@1|root,arCOG00060@2157|Archaea,2XT98@28890|Euryarchaeota,241P8@183967|Thermoplasmata	183967|Thermoplasmata	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
MMS2_k127_3155880_7	273075.Ta0081	1.338e-31	132.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,241UQ@183967|Thermoplasmata	183967|Thermoplasmata	F	dTDP metabolic process	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS2_k127_3155880_3	273116.14324329	1.275e-71	249.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,242F5@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS2_k127_3155880_4	485918.Cpin_5720	1.452e-38	145.0	2C82G@1|root,32RK9@2|Bacteria,4NSXV@976|Bacteroidetes,1IYD5@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
MMS2_k127_3155880_8	868131.MSWAN_0168	3.883e-27	113.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,23PE2@183925|Methanobacteria	28890|Euryarchaeota	E	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	-	-	4.1.1.15,4.1.2.27	ko:K01580,ko:K01634	ko00250,ko00410,ko00430,ko00600,ko00650,ko01100,ko01110,ko01120,ko02024,ko04071,ko04727,ko04940,map00250,map00410,map00430,map00600,map00650,map01100,map01110,map01120,map02024,map04071,map04727,map04940	M00027,M00100	R00261,R00489,R01682,R02464,R02466,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
MMS2_k127_31599_3	1417296.U879_03690	8.64e-60	214.0	COG1145@1|root,COG1456@1|root,COG1145@2|Bacteria,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,2USUR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	CO dehydrogenase/acetyl-CoA synthase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CdhD,Fer4
MMS2_k127_31599_2	1417296.U879_03685	1.813e-60	217.0	COG0500@1|root,COG2226@2|Bacteria,1R41W@1224|Proteobacteria,2UJDA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS2_k127_31599_0	351160.RCIX1093	6.258e-116	381.0	COG1073@1|root,arCOG01661@2157|Archaea,2XVIC@28890|Euryarchaeota,2NANZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
MMS2_k127_31599_1	263820.PTO0094	1.139e-68	239.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y10K@28890|Euryarchaeota,2428W@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_31599_5	673860.AciM339_1043	1.773e-07	63.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_31599_4	273063.STK_19010	1.592e-10	63.0	COG1914@1|root,arCOG04531@2157|Archaea,2XRNF@28889|Crenarchaeota	28889|Crenarchaeota	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
MMS2_k127_317600_4	263820.PTO1199	2.527e-14	73.0	COG0142@1|root,arCOG01726@2157|Archaea,2XT85@28890|Euryarchaeota,241QG@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS2_k127_317600_0	273075.Ta0912	9.164e-37	142.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,242BE@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMS2_k127_317600_1	263820.PTO1201	6.364e-35	137.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX5M@28890|Euryarchaeota,241X8@183967|Thermoplasmata	183967|Thermoplasmata	K	helix_turn_helix ASNC type	-	-	-	ko:K06154	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
MMS2_k127_317600_2	273075.Ta0916	5.979e-29	117.0	arCOG05390@1|root,arCOG05390@2157|Archaea,2Y4YT@28890|Euryarchaeota,242E1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_317600_3	1120792.JAFV01000001_gene816	5.746e-25	110.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
MMS2_k127_3177268_4	273075.Ta0622	4.529e-36	138.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,241Q7@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMS2_k127_3177268_3	439481.Aboo_0079	1.17e-38	154.0	COG0483@1|root,arCOG01349@2157|Archaea,2Y87S@28890|Euryarchaeota,3F2MR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
MMS2_k127_3177268_0	263820.PTO1222	5.298e-104	344.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,241P6@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
MMS2_k127_3177268_1	263820.PTO1221	6.308e-67	229.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,241PM@183967|Thermoplasmata	183967|Thermoplasmata	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS2_k127_3177268_2	263820.PTO1220	9.26e-61	214.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,241PV@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMS2_k127_3213748_6	1459636.NTE_03133	1.151e-44	174.0	COG0640@1|root,COG1809@1|root,arCOG00394@2157|Archaea,arCOG04896@2157|Archaea	2157|Archaea	K	PFAM (2R)-phospho-3-sulfolactate synthase ComA	comA	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	4.4.1.19	ko:K08097	ko00680,ko01120,map00680,map01120	M00358	R07476	RC01799	ko00000,ko00001,ko00002,ko01000	-	-	-	ComA
MMS2_k127_3213748_3	397948.Cmaq_0187	6.993e-72	248.0	COG1584@1|root,arCOG03176@2157|Archaea	2157|Archaea	S	GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
MMS2_k127_3213748_8	273075.Ta0887	1.91e-25	115.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y72P@28890|Euryarchaeota,2428V@183967|Thermoplasmata	183967|Thermoplasmata	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS2_k127_3213748_1	634956.Geoth_2534	1.878e-90	314.0	COG0477@1|root,COG2814@2|Bacteria,1TQM0@1239|Firmicutes,4HATA@91061|Bacilli,1WHZ9@129337|Geobacillus	91061|Bacilli	P	Sugar (and other) transporter	-	-	-	ko:K08368,ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1	-	-	MFS_1,Sugar_tr
MMS2_k127_3213748_4	1382304.JNIL01000001_gene2947	8.128e-69	241.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes	1239|Firmicutes	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	Big_2,GDPD,GPDPase_memb
MMS2_k127_3213748_0	273075.Ta0861	5.302e-93	314.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,242D0@183967|Thermoplasmata	183967|Thermoplasmata	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
MMS2_k127_3213748_2	263820.PTO0184	2.392e-88	301.0	COG1878@1|root,arCOG02462@2157|Archaea,2XX0R@28890|Euryarchaeota	28890|Euryarchaeota	E	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
MMS2_k127_3213748_5	266117.Rxyl_1661	2.423e-53	192.0	COG1247@1|root,COG1247@2|Bacteria,2H1MI@201174|Actinobacteria,4CQH6@84995|Rubrobacteria	84995|Rubrobacteria	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
MMS2_k127_3213748_7	714961.BFZC1_13453	3.627e-44	168.0	COG1670@1|root,COG1670@2|Bacteria,1V5BA@1239|Firmicutes,4HHR5@91061|Bacilli,3IXHY@400634|Lysinibacillus	91061|Bacilli	J	GNAT family acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_3213748_9	926560.KE387027_gene822	3.674e-13	77.0	COG0454@1|root,COG0456@2|Bacteria,1WMTD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
MMS2_k127_3213748_10	397948.Cmaq_0355	2.45e-06	56.0	COG0454@1|root,arCOG00845@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
MMS2_k127_3244644_3	263820.PTO0755	5.485e-27	115.0	COG1661@1|root,arCOG04212@2157|Archaea,2Y7CU@28890|Euryarchaeota,242DU@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMS2_k127_3244644_4	930945.SiRe_2083	1.057e-20	97.0	COG0494@1|root,arCOG01072@2157|Archaea,2XRJY@28889|Crenarchaeota	28889|Crenarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS2_k127_3244644_2	263820.PTO0918	1.859e-51	199.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,241SI@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS2_k127_3244644_1	273075.Ta0537m	1.156e-109	360.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,241SF@183967|Thermoplasmata	183967|Thermoplasmata	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
MMS2_k127_3244644_0	273075.Ta0529m	1.921e-133	435.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,241M6@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_3244644_5	273075.Ta0528	1.033e-18	87.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,241Q2@183967|Thermoplasmata	183967|Thermoplasmata	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
MMS2_k127_3278612_5	273075.Ta1377	1.298e-15	80.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_3278612_3	273116.14325508	1.239e-23	106.0	COG1846@1|root,arCOG03181@2157|Archaea	2157|Archaea	K	Transcriptional regulator MarR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
MMS2_k127_3278612_0	273075.Ta0410	3.861e-208	663.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XVRP@28890|Euryarchaeota,2420N@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_3278612_2	221027.JO40_12795	1.022e-43	174.0	COG0438@1|root,COG0438@2|Bacteria,2J7E2@203691|Spirochaetes	203691|Spirochaetes	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_3278612_1	273075.Ta0480	1.249e-83	287.0	COG2423@1|root,arCOG01035@2157|Archaea,2XT4P@28890|Euryarchaeota,24266@183967|Thermoplasmata	183967|Thermoplasmata	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
MMS2_k127_3278612_4	273075.Ta1422	2.118e-20	93.0	arCOG05376@1|root,arCOG05376@2157|Archaea,2Y4VU@28890|Euryarchaeota,242E3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3278612_6	273116.14324634	1.691e-07	52.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,241J4@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS2_k127_3294274_0	673860.AciM339_0729	4.203e-185	591.0	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,3F380@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
MMS2_k127_3294274_3	273116.14325641	1.369e-50	188.0	COG1427@1|root,arCOG00655@2157|Archaea,2Y266@28890|Euryarchaeota	28890|Euryarchaeota	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
MMS2_k127_3294274_2	673860.AciM339_0333	9.252e-94	317.0	COG0451@1|root,arCOG04468@2157|Archaea,2XT9R@28890|Euryarchaeota,3F346@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_3294274_1	273075.Ta1189	3.59e-182	577.0	COG0156@1|root,arCOG00113@2157|Archaea,2XUFG@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_3300992_2	273116.14324981	6.36e-11	74.0	arCOG05363@1|root,arCOG05363@2157|Archaea,2Y4TQ@28890|Euryarchaeota,242DI@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3300992_0	263820.PTO0778	1.069e-79	273.0	COG0013@1|root,arCOG01254@2157|Archaea,2Y3DT@28890|Euryarchaeota,2426U@183967|Thermoplasmata	183967|Thermoplasmata	J	Related to alanyl-tRNA synthetase HxxxH domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	-
MMS2_k127_3300992_1	263820.PTO1256	6.381e-20	91.0	COG0294@1|root,arCOG02817@2157|Archaea,2XTGI@28890|Euryarchaeota,241P1@183967|Thermoplasmata	183967|Thermoplasmata	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS2_k127_3304746_1	273075.Ta0472	3.604e-38	150.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y680@28890|Euryarchaeota,241VW@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS2_k127_3304746_0	273075.Ta0471	9.273e-49	180.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y89K@28890|Euryarchaeota,242IE@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMS2_k127_3304746_2	263820.PTO1146	3.495e-11	65.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,242EE@183967|Thermoplasmata	183967|Thermoplasmata	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMS2_k127_3308777_1	273075.Ta0413	1.575e-85	291.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMS2_k127_3308777_0	273116.14325299	3.914e-111	369.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,241KG@183967|Thermoplasmata	183967|Thermoplasmata	L	MCM OB domain	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_OB
MMS2_k127_3314605_1	273116.14325668	9.472e-49	184.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,241PB@183967|Thermoplasmata	183967|Thermoplasmata	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMS2_k127_3314605_2	697281.Mahau_1263	3.275e-13	76.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,42G5T@68295|Thermoanaerobacterales	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS2_k127_3314605_0	263820.PTO0712	3.353e-63	224.0	COG0108@1|root,arCOG01320@2157|Archaea,2XTDZ@28890|Euryarchaeota,2427X@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	-	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
MMS2_k127_3320276_0	273116.14324831	4.118e-51	199.0	COG0457@1|root,arCOG05326@2157|Archaea,2Y4PM@28890|Euryarchaeota,242DR@183967|Thermoplasmata	183967|Thermoplasmata	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
MMS2_k127_3320276_1	273075.Ta0562	5.289e-42	161.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,241UR@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3320276_4	263820.PTO1163	1.377e-21	96.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y77Z@28890|Euryarchaeota,242HV@183967|Thermoplasmata	183967|Thermoplasmata	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMS2_k127_3320276_2	273116.14324834	1.094e-23	102.0	COG2092@1|root,arCOG01988@2157|Archaea,2Y7BM@28890|Euryarchaeota,242D1@183967|Thermoplasmata	183967|Thermoplasmata	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
MMS2_k127_3320276_3	273116.14324833	2.404e-23	104.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7AD@28890|Euryarchaeota,24212@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_21
MMS2_k127_3330023_1	697282.Mettu_3234	1.804e-52	190.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1XEWT@135618|Methylococcales	135618|Methylococcales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMS2_k127_3330023_0	1172562.HCN_1558	5.049e-66	238.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N31@68525|delta/epsilon subdivisions,2YN6V@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
MMS2_k127_3358187_9	273116.14324982	3.321e-10	64.0	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMS2_k127_3358187_8	273075.Ta1056	3.685e-25	106.0	arCOG04007@1|root,arCOG04007@2157|Archaea,2Y580@28890|Euryarchaeota,242FA@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3358187_0	273075.Ta1055	7.345e-280	872.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,241Z0@183967|Thermoplasmata	183967|Thermoplasmata	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS2_k127_3358187_1	263820.PTO1415	1.231e-272	860.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,241JQ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA Topoisomerase IV	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS2_k127_3358187_7	273075.Ta0668	1.16e-58	215.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,241WV@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_3358187_5	263820.PTO1500	7.152e-73	255.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,241RK@183967|Thermoplasmata	183967|Thermoplasmata	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS2_k127_3358187_3	273075.Ta1380	5.012e-139	453.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2423F@183967|Thermoplasmata	183967|Thermoplasmata	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMS2_k127_3358187_4	263820.PTO0172	1.23e-92	313.0	COG2421@1|root,arCOG01004@2157|Archaea,2XU60@28890|Euryarchaeota	28890|Euryarchaeota	C	acetamidase formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
MMS2_k127_3358187_6	273057.SSO2071	1.416e-61	216.0	COG1225@1|root,arCOG00310@2157|Archaea,2XRWS@28889|Crenarchaeota	28889|Crenarchaeota	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS2_k127_3358187_2	1056495.Calag_0187	1.627e-193	613.0	COG0160@1|root,arCOG00916@2157|Archaea,2XPMV@28889|Crenarchaeota	28889|Crenarchaeota	E	Aminotransferase class-III	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
MMS2_k127_3360150_0	273116.14324860	1.088e-35	151.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241JN@183967|Thermoplasmata	183967|Thermoplasmata	K	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS2_k127_3360150_1	589924.Ferp_0541	3.541e-17	87.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,246Q2@183980|Archaeoglobi	183980|Archaeoglobi	K	Transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS2_k127_3370974_1	263820.PTO0808	8.944e-56	201.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,241Q4@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMS2_k127_3370974_2	273075.Ta1317a	2.966e-16	78.0	COG1552@1|root,arCOG04049@2157|Archaea	2157|Archaea	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMS2_k127_3370974_0	263820.PTO0806	1.344e-90	310.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,241RB@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS2_k127_3393487_0	439481.Aboo_1300	3.951e-143	467.0	COG1363@1|root,arCOG01518@2157|Archaea,2XW74@28890|Euryarchaeota,3F2FY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Aminopeptidase I zinc metalloprotease (M18)	-	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
MMS2_k127_3393487_6	1304866.K413DRAFT_3581	2.355e-11	71.0	COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,24KFX@186801|Clostridia,36MGM@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_3393487_4	273075.Ta1353m	9.166e-66	228.0	COG1839@1|root,arCOG04298@2157|Archaea,2XY40@28890|Euryarchaeota,2426Q@183967|Thermoplasmata	183967|Thermoplasmata	L	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
MMS2_k127_3393487_2	397948.Cmaq_0176	1.383e-107	371.0	COG0038@1|root,arCOG02569@2157|Archaea,2XQ0P@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CBS domain	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS2_k127_3393487_3	263820.PTO0637	1.218e-69	239.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,242AD@183967|Thermoplasmata	183967|Thermoplasmata	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
MMS2_k127_3393487_5	273075.Ta0842	4.61e-35	138.0	COG1321@1|root,arCOG02100@2157|Archaea,2Y7B9@28890|Euryarchaeota,242AG@183967|Thermoplasmata	183967|Thermoplasmata	K	Iron dependent repressor, metal binding and dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
MMS2_k127_3393487_1	273075.Ta1156	9.373e-119	389.0	arCOG06008@1|root,arCOG06008@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3404099_1	263820.PTO0856	1.078e-65	243.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,241K1@183967|Thermoplasmata	183967|Thermoplasmata	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS2_k127_3404099_2	273116.14325038	7.508e-20	99.0	COG1354@1|root,arCOG02610@2157|Archaea,2Y6XG@28890|Euryarchaeota,241WP@183967|Thermoplasmata	183967|Thermoplasmata	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	-
MMS2_k127_3404099_3	697303.Thewi_2014	7.655e-09	64.0	COG1468@1|root,COG1468@2|Bacteria,1V1U1@1239|Firmicutes,24H50@186801|Clostridia,42G0A@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
MMS2_k127_3404099_0	263820.PTO0226	2.098e-111	369.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,241NP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMS2_k127_3410914_0	273116.14324457	6.941e-247	772.0	COG0243@1|root,arCOG01492@2157|Archaea,2Y8AB@28890|Euryarchaeota,2425G@183967|Thermoplasmata	183967|Thermoplasmata	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS2_k127_3410914_3	273116.14324458	6.842e-19	92.0	COG2427@1|root,arCOG07741@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS2_k127_3410914_1	263820.PTO1037	1.027e-67	240.0	COG1526@1|root,arCOG04358@2157|Archaea,2XYNI@28890|Euryarchaeota,2427S@183967|Thermoplasmata	183967|Thermoplasmata	H	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
MMS2_k127_3410914_2	273116.14325532	1.334e-33	136.0	COG0746@1|root,arCOG01872@2157|Archaea,2Y4WY@28890|Euryarchaeota,242C0@183967|Thermoplasmata	183967|Thermoplasmata	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
MMS2_k127_3410914_4	1077144.AGFF01000005_gene2142	0.0001677	48.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria	201174|Actinobacteria	H	Molybdenum cofactor synthesis domain protein	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
MMS2_k127_342105_0	273075.Ta0462	1.236e-173	548.0	COG1884@1|root,arCOG04232@2157|Archaea,2XU3F@28890|Euryarchaeota,24230@183967|Thermoplasmata	183967|Thermoplasmata	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS2_k127_342105_3	1459636.NTE_01111	1.345e-48	177.0	COG2185@1|root,arCOG01710@2157|Archaea,41SJN@651137|Thaumarchaeota	651137|Thaumarchaeota	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
MMS2_k127_342105_1	273116.14325004	1.666e-87	301.0	COG1703@1|root,arCOG01226@2157|Archaea,2XUHG@28890|Euryarchaeota,2421X@183967|Thermoplasmata	183967|Thermoplasmata	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
MMS2_k127_342105_4	263820.PTO0739	3.561e-39	149.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y7BQ@28890|Euryarchaeota,242D8@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMS2_k127_342105_2	263820.PTO0740	1.287e-55	199.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,24200@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
MMS2_k127_3447557_3	1050201.KB913034_gene908	5.652e-36	144.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,3VQY8@526524|Erysipelotrichia	526524|Erysipelotrichia	S	Metallo-beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_3447557_2	273075.Ta0124m	1.404e-73	254.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,241V1@183967|Thermoplasmata	183967|Thermoplasmata	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS2_k127_3447557_1	273075.Ta0125	1.149e-95	317.0	COG0526@1|root,arCOG01218@2157|Archaea,2XY63@28890|Euryarchaeota,2423H@183967|Thermoplasmata	183967|Thermoplasmata	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
MMS2_k127_3447557_4	1121472.AQWN01000009_gene291	1.089e-10	66.0	COG3255@1|root,COG3255@2|Bacteria,1VFEY@1239|Firmicutes,24QXQ@186801|Clostridia,263BY@186807|Peptococcaceae	186801|Clostridia	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS2_k127_3447557_0	273075.Ta0291	3.485e-117	385.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,24225@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS2_k127_3451186_3	273075.Ta0761	2.683e-11	67.0	COG1335@1|root,arCOG01943@2157|Archaea,2Y50P@28890|Euryarchaeota,242C3@183967|Thermoplasmata	183967|Thermoplasmata	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS2_k127_3451186_1	273116.14325083	5.974e-47	175.0	COG2074@1|root,arCOG01967@2157|Archaea,2Y11V@28890|Euryarchaeota,2427Z@183967|Thermoplasmata	183967|Thermoplasmata	F	AAA domain	-	GO:0003674,GO:0003824,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576	2.7.1.186	ko:K18690	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10780	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	AAA_18
MMS2_k127_3451186_0	273075.Ta0893	2.179e-83	289.0	COG3407@1|root,arCOG02937@2157|Archaea,2XUJ7@28890|Euryarchaeota,2426X@183967|Thermoplasmata	183967|Thermoplasmata	I	isoprenoid metabolic process	-	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_3451186_4	251229.Chro_1290	3.401e-07	60.0	COG1403@1|root,COG1403@2|Bacteria,1G7VH@1117|Cyanobacteria,3VKUJ@52604|Pleurocapsales	1117|Cyanobacteria	L	HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH,HNH_5
MMS2_k127_3451186_2	273075.Ta0577	2.965e-28	116.0	COG0665@1|root,arCOG00755@2157|Archaea,2Y66F@28890|Euryarchaeota,24239@183967|Thermoplasmata	183967|Thermoplasmata	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
MMS2_k127_3472922_5	1449063.JMLS01000005_gene3101	4.794e-12	68.0	COG1011@1|root,COG1011@2|Bacteria,1TS3W@1239|Firmicutes	1239|Firmicutes	T	hydrolase (HAD superfamily)	-	-	3.1.3.5,3.8.1.2	ko:K01560,ko:K07025,ko:K08723	ko00230,ko00240,ko00361,ko00625,ko00760,ko01100,ko01110,ko01120,map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R05287	RC00017,RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS2_k127_3472922_3	999630.TUZN_1231	5.485e-25	113.0	arCOG05636@1|root,arCOG05636@2157|Archaea,2XRH9@28889|Crenarchaeota	28889|Crenarchaeota	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
MMS2_k127_3472922_1	273063.STK_06200	7.47e-34	134.0	COG4911@1|root,arCOG05495@2157|Archaea,2XSGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
MMS2_k127_3472922_2	273116.14325275	2.243e-29	121.0	COG3439@1|root,arCOG02761@2157|Archaea,2Y7BY@28890|Euryarchaeota,242F7@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
MMS2_k127_3472922_4	273116.14325611	1.468e-22	102.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y01N@28890|Euryarchaeota,242D9@183967|Thermoplasmata	183967|Thermoplasmata	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMS2_k127_3472922_0	273116.14325083	9.523e-54	196.0	COG2074@1|root,arCOG01967@2157|Archaea,2Y11V@28890|Euryarchaeota,2427Z@183967|Thermoplasmata	183967|Thermoplasmata	F	AAA domain	-	GO:0003674,GO:0003824,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576	2.7.1.186	ko:K18690	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10780	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	AAA_18
MMS2_k127_3479090_1	273075.Ta0333	3.161e-143	462.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,241IR@183967|Thermoplasmata	183967|Thermoplasmata	J	Beta-Casp domain	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
MMS2_k127_3479090_2	263820.PTO0942	3.596e-116	378.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,241MI@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS2_k127_3479090_3	263820.PTO1047	1.048e-53	197.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,241TS@183967|Thermoplasmata	183967|Thermoplasmata	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
MMS2_k127_3479090_0	263820.PTO1161	7.072e-219	690.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2420R@183967|Thermoplasmata	183967|Thermoplasmata	V	Pfam:KH_3	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,T2SSE
MMS2_k127_351541_2	273116.14324267	2.136e-44	166.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,241TN@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS2_k127_351541_1	273116.14324266	1.485e-232	726.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,241K0@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_351541_0	697281.Mahau_0630	0.0	1031.0	COG1155@1|root,COG1372@1|root,COG1155@2|Bacteria,COG1372@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
MMS2_k127_3520107_0	273116.14325598	7.175e-225	706.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,241S7@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS2_k127_3520107_1	273075.Ta0258	1.395e-199	630.0	COG1027@1|root,arCOG01750@2157|Archaea,2Y84P@28890|Euryarchaeota,2422A@183967|Thermoplasmata	183967|Thermoplasmata	E	Fumarase C C-terminus	-	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS2_k127_3520107_2	273075.Ta0256	2.35e-30	122.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,241MG@183967|Thermoplasmata	183967|Thermoplasmata	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
MMS2_k127_3534503_1	263820.PTO1226	2.088e-75	263.0	COG0166@1|root,arCOG00052@2157|Archaea,2XYUK@28890|Euryarchaeota,241R6@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
MMS2_k127_3534503_0	263820.PTO1225	5.398e-161	524.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,241KK@183967|Thermoplasmata	183967|Thermoplasmata	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS2_k127_3542614_2	1206101.AZXC01000006_gene4116	4.682e-05	47.0	COG1670@1|root,COG1670@2|Bacteria,2IE9P@201174|Actinobacteria	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_3542614_1	1380390.JIAT01000012_gene3101	2.112e-29	127.0	2AWU5@1|root,31NRA@2|Bacteria,2HR9Y@201174|Actinobacteria,4CT6Q@84995|Rubrobacteria	84995|Rubrobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3542614_0	263820.PTO1014	2.157e-80	281.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2422F@183967|Thermoplasmata	183967|Thermoplasmata	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
MMS2_k127_3554391_1	1365176.N186_03985	4.482e-26	113.0	COG4113@1|root,arCOG00727@2157|Archaea,2XR7P@28889|Crenarchaeota	28889|Crenarchaeota	V	PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS2_k127_3554391_2	1459636.NTE_00255	5.33e-17	83.0	arCOG07235@1|root,arCOG07235@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3554391_0	273075.Ta0840	0.0	1247.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,241IB@183967|Thermoplasmata	183967|Thermoplasmata	O	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMS2_k127_3554391_3	263820.PTO0475	1.391e-16	80.0	COG0665@1|root,arCOG00755@2157|Archaea,2Y66F@28890|Euryarchaeota,24239@183967|Thermoplasmata	183967|Thermoplasmata	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
MMS2_k127_3575324_0	273075.Ta0291	4.604e-103	344.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,24225@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS2_k127_3575324_1	930945.SiRe_0588	1.819e-73	258.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_3575324_2	933801.Ahos_1732	4.216e-09	69.0	COG1277@1|root,arCOG02441@2157|Archaea,2XQE4@28889|Crenarchaeota	28889|Crenarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_3588797_2	263820.PTO0541	2.725e-102	340.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2424I@183967|Thermoplasmata	183967|Thermoplasmata	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS2_k127_3588797_0	273075.Ta1060m	3.521e-154	497.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,241JE@183967|Thermoplasmata	183967|Thermoplasmata	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS2_k127_3588797_4	273075.Ta0918	3.777e-17	92.0	arCOG07396@1|root,arCOG07396@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3588797_3	273116.14325328	5.892e-87	303.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS2_k127_3588797_1	273116.14325329	3.394e-124	405.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota	28890|Euryarchaeota	S	ATPase associated with various cellular activities	moxR4	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS2_k127_3588797_5	273116.14325330	2.796e-09	64.0	arCOG07743@1|root,arCOG07743@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3593112_3	273075.Ta0333	8.635e-14	71.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,241IR@183967|Thermoplasmata	183967|Thermoplasmata	J	Beta-Casp domain	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
MMS2_k127_3593112_1	263820.PTO1420	1.812e-43	166.0	arCOG05407@1|root,arCOG05407@2157|Archaea,2Y3B8@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3593112_0	273075.Ta0387	8.219e-73	258.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,241TQ@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS2_k127_3593112_2	263820.PTO1418	1.425e-25	109.0	COG3390@1|root,arCOG02258@2157|Archaea,2Y7QP@28890|Euryarchaeota,241WM@183967|Thermoplasmata	183967|Thermoplasmata	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
MMS2_k127_3630481_1	273075.Ta1147	2.213e-49	183.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,241IS@183967|Thermoplasmata	183967|Thermoplasmata	J	cysteine-tRNA ligase activity	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
MMS2_k127_3630481_2	309799.DICTH_1851	2.235e-33	135.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase,MerR_1
MMS2_k127_3630481_0	273116.14325505	4.88e-140	454.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota,241KX@183967|Thermoplasmata	183967|Thermoplasmata	H	Quinolinate phosphoribosyl transferase, C-terminal domain	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C
MMS2_k127_3630481_3	273116.14325187	6.333e-17	83.0	COG0637@1|root,arCOG02293@2157|Archaea,2Y6Y6@28890|Euryarchaeota,241WQ@183967|Thermoplasmata	183967|Thermoplasmata	S	HAD-hyrolase-like	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
MMS2_k127_3635437_3	1249997.JHZW01000003_gene2505	3.023e-15	83.0	COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,1HWQA@117743|Flavobacteriia,2PGX3@252356|Maribacter	976|Bacteroidetes	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
MMS2_k127_3635437_2	263820.PTO1410	1.496e-22	98.0	arCOG05405@1|root,arCOG05405@2157|Archaea,2Y539@28890|Euryarchaeota,242FK@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3635437_4	273075.Ta0958	1.467e-11	69.0	arCOG05378@1|root,arCOG05378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3635437_1	273075.Ta0959	1.021e-134	445.0	COG1007@1|root,arCOG01540@2157|Archaea,2XSY7@28890|Euryarchaeota,241P2@183967|Thermoplasmata	183967|Thermoplasmata	C	Proton-conducting membrane transporter	-	-	1.5.98.3,1.6.5.3	ko:K00343,ko:K22169	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M
MMS2_k127_3635437_0	273116.14325367	1.38e-136	450.0	COG1008@1|root,arCOG01538@2157|Archaea,2XTP0@28890|Euryarchaeota,241NU@183967|Thermoplasmata	183967|Thermoplasmata	C	Proton-conducting membrane transporter	-	-	1.5.98.3,1.6.5.3	ko:K00342,ko:K22168	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M
MMS2_k127_3648615_1	273075.Ta0662m	1.422e-33	137.0	COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota	28890|Euryarchaeota	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
MMS2_k127_3648615_0	330779.Saci_2208	1.669e-89	304.0	COG1250@1|root,arCOG00249@2157|Archaea,2XPQ7@28889|Crenarchaeota	28889|Crenarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS2_k127_367671_7	273116.14325497	4.404e-24	105.0	COG1658@1|root,arCOG01486@2157|Archaea	2157|Archaea	L	Belongs to the UPF0292 family	-	-	-	-	-	-	-	-	-	-	-	-	Toprim,Toprim_4
MMS2_k127_367671_0	273075.Ta0838	0.0	1052.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241ID@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS2_k127_367671_1	273116.14324736	9.046e-237	754.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,241M2@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_367671_8	263820.PTO1204	1.156e-12	71.0	COG1828@1|root,arCOG04462@2157|Archaea,2Y79Q@28890|Euryarchaeota,241WD@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMS2_k127_367671_3	263820.PTO0183	9.23e-87	293.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,241NR@183967|Thermoplasmata	183967|Thermoplasmata	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMS2_k127_367671_5	273075.Ta0996m	7.19e-68	240.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,241QE@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMS2_k127_367671_2	263820.PTO0220	5.605e-93	317.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,241SG@183967|Thermoplasmata	183967|Thermoplasmata	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMS2_k127_367671_4	273116.14324964	1.032e-78	267.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,241QZ@183967|Thermoplasmata	183967|Thermoplasmata	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMS2_k127_367671_6	273116.14324965	7.796e-48	174.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,241TA@183967|Thermoplasmata	183967|Thermoplasmata	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
MMS2_k127_3683344_1	273063.STK_11200	7.99e-32	127.0	COG0167@1|root,arCOG00603@2157|Archaea,2XQ06@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM dihydroorotate dehydrogenase family protein	-	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4,Fer4_21
MMS2_k127_3683344_0	273063.STK_11210	1.551e-119	390.0	COG0388@1|root,arCOG00062@2157|Archaea,2XPK5@28889|Crenarchaeota	2157|Archaea	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6,3.5.3.12	ko:K01431,ko:K10536	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01416,R04666,R08228	RC00096,RC00177	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,PAD_porph
MMS2_k127_3683344_2	263820.PTO0739	0.0005787	45.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y7BQ@28890|Euryarchaeota,242D8@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMS2_k127_3697599_0	586416.GZ22_07965	2.735e-54	200.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli	91061|Bacilli	G	Protein conserved in bacteria	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
MMS2_k127_3697599_1	273116.14324413	5.818e-35	147.0	COG2971@1|root,arCOG03659@2157|Archaea,2Y02S@28890|Euryarchaeota,2428D@183967|Thermoplasmata	183967|Thermoplasmata	G	BadF/BadG/BcrA/BcrD ATPase family	-	-	2.7.1.59	ko:K00884	ko00520,ko01100,map00520,map01100	-	R01201	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	BcrAD_BadFG
MMS2_k127_3721224_0	273063.STK_19010	1.55e-111	371.0	COG1914@1|root,arCOG04531@2157|Archaea,2XRNF@28889|Crenarchaeota	28889|Crenarchaeota	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
MMS2_k127_3721224_2	263820.PTO1076	4.986e-44	170.0	COG0338@1|root,arCOG03416@2157|Archaea,2XWJX@28890|Euryarchaeota	28890|Euryarchaeota	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMS2_k127_3721224_4	485913.Krac_1995	2.693e-39	150.0	COG5649@1|root,COG5649@2|Bacteria	2|Bacteria	E	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS2_k127_3721224_1	525904.Tter_2394	1.223e-46	171.0	COG5646@1|root,COG5646@2|Bacteria,2NQX2@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS2_k127_3721224_3	1174528.JH992898_gene3564	1.497e-43	163.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria,1JIE9@1189|Stigonemataceae	1117|Cyanobacteria	FL	Metal binding domain of Ada	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
MMS2_k127_3722461_2	273116.14324633	5.223e-39	145.0	COG0421@1|root,arCOG00050@2157|Archaea,2XV5K@28890|Euryarchaeota,2422Q@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
MMS2_k127_3722461_3	273075.Ta0093	3.538e-37	141.0	COG0776@1|root,arCOG05336@2157|Archaea,2XZF7@28890|Euryarchaeota,242BD@183967|Thermoplasmata	183967|Thermoplasmata	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS2_k127_3722461_1	273075.Ta1358	7.557e-145	471.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,24213@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS2_k127_3722461_0	273116.14324516	7.317e-205	647.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,241YN@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS2_k127_3722461_4	273116.14325448	1.376e-14	77.0	COG3390@1|root,arCOG02258@2157|Archaea,2Y7QP@28890|Euryarchaeota,241WM@183967|Thermoplasmata	183967|Thermoplasmata	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
MMS2_k127_3740526_0	273116.14325668	1.292e-87	302.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,241PB@183967|Thermoplasmata	183967|Thermoplasmata	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMS2_k127_3740526_2	273116.14325478	5.864e-33	133.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y7BR@28890|Euryarchaeota,242DG@183967|Thermoplasmata	183967|Thermoplasmata	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS2_k127_3740526_1	273116.14325477	5.402e-46	169.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,241VG@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS2_k127_3754229_0	1121472.AQWN01000004_gene802	2.087e-137	448.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
MMS2_k127_3754229_4	398720.MED217_11084	2.243e-06	56.0	COG0454@1|root,COG0456@2|Bacteria,4PE0E@976|Bacteroidetes,1IEEA@117743|Flavobacteriia,2XK0J@283735|Leeuwenhoekiella	976|Bacteroidetes	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_3754229_2	1123405.AUMM01000007_gene926	2.942e-75	269.0	COG4934@1|root,COG4934@2|Bacteria,1UYFY@1239|Firmicutes,4HFAH@91061|Bacilli,26PHT@186821|Sporolactobacillaceae	91061|Bacilli	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,Pro-kuma_activ
MMS2_k127_3754229_1	216594.MMAR_0119	1.22e-124	410.0	COG0778@1|root,COG0778@2|Bacteria,2H3K6@201174|Actinobacteria	201174|Actinobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
MMS2_k127_3754229_3	1267005.KB911259_gene3771	8.797e-27	117.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
MMS2_k127_3763352_4	273116.14325477	8.906e-20	91.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,241VG@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS2_k127_3763352_2	273116.14324382	1.34e-45	172.0	COG0491@1|root,arCOG00504@2157|Archaea,2Y7BK@28890|Euryarchaeota,242CU@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_3763352_5	439481.Aboo_0781	1.211e-12	78.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
MMS2_k127_3763352_3	273116.14325475	1.313e-33	132.0	COG1382@1|root,arCOG01342@2157|Archaea,2Y79P@28890|Euryarchaeota,241WC@183967|Thermoplasmata	183967|Thermoplasmata	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMS2_k127_3763352_0	1056495.Calag_0085	1.289e-137	448.0	COG1804@1|root,arCOG02304@2157|Archaea,2XPYW@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
MMS2_k127_3763352_6	330779.Saci_1729	6.005e-10	64.0	COG1545@1|root,arCOG01285@2157|Archaea	2157|Archaea	I	nucleic-acid-binding protein containing a Zn-ribbon	-	-	1.1.1.157	ko:K00074,ko:K07068	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	OB_aCoA_assoc
MMS2_k127_3763352_1	930945.SiRe_2502	3.088e-119	393.0	COG0183@1|root,arCOG01278@2157|Archaea,2XPQD@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM Thiolase	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_3765423_2	629742.STAHO0001_1534	5.534e-18	86.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HA6Z@91061|Bacilli,4GXER@90964|Staphylococcaceae	91061|Bacilli	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS2_k127_3765423_1	479434.Sthe_1526	1.97e-30	123.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi,27YGN@189775|Thermomicrobia	189775|Thermomicrobia	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMS2_k127_3765423_0	263820.PTO1115	5.508e-87	295.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,241RP@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_3777295_0	273075.Ta1210	4.358e-161	518.0	COG0380@1|root,arCOG02831@2157|Archaea,2XSTE@28890|Euryarchaeota,241YH@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
MMS2_k127_3777295_1	273116.14325517	5.509e-52	192.0	COG1877@1|root,arCOG01216@2157|Archaea,2Y7BA@28890|Euryarchaeota,242AK@183967|Thermoplasmata	183967|Thermoplasmata	G	Removes the phosphate from trehalose 6-phosphate	-	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
MMS2_k127_3777295_2	273116.14325519	2.596e-27	114.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota	28890|Euryarchaeota	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.100	ko:K18540	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
MMS2_k127_3777988_0	263820.PTO1307	3.942e-87	296.0	COG0109@1|root,arCOG00479@2157|Archaea,2XUEM@28890|Euryarchaeota	28890|Euryarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
MMS2_k127_3777988_1	263820.PTO1298	7.735e-33	144.0	arCOG06974@1|root,arCOG06974@2157|Archaea,2Y4TI@28890|Euryarchaeota,242C1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3777988_2	797209.ZOD2009_05132	8.124e-17	85.0	COG0824@1|root,arCOG01137@2157|Archaea,2XZ99@28890|Euryarchaeota,23WUB@183963|Halobacteria	183963|Halobacteria	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
MMS2_k127_3777988_4	263820.PTO1224	0.0009819	49.0	arCOG07416@1|root,arCOG07416@2157|Archaea	2157|Archaea	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
MMS2_k127_3777988_3	263820.PTO1225	4.256e-14	73.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,241KK@183967|Thermoplasmata	183967|Thermoplasmata	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS2_k127_377852_9	273116.14325354	1.34e-09	60.0	arCOG05393@1|root,arCOG05393@2157|Archaea,2Y5IJ@28890|Euryarchaeota,242HG@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_377852_4	273075.Ta0947	5.69e-96	324.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS2_k127_377852_7	1211777.BN77_p11184	1.242e-27	121.0	COG0300@1|root,COG0300@2|Bacteria,1R27W@1224|Proteobacteria,2TZD9@28211|Alphaproteobacteria,4BCEC@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS2_k127_377852_6	479433.Caci_5199	2.259e-43	171.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria	201174|Actinobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMS2_k127_377852_1	273075.Ta0946	4.761e-177	563.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,241JY@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS2_k127_377852_3	273075.Ta1083	1.99e-102	348.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,2421P@183967|Thermoplasmata	183967|Thermoplasmata	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
MMS2_k127_377852_2	273116.14324955	1.707e-131	425.0	COG1940@1|root,arCOG04280@2157|Archaea,2XUQY@28890|Euryarchaeota,24259@183967|Thermoplasmata	183967|Thermoplasmata	G	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMS2_k127_377852_8	1123303.AQVD01000001_gene864	1.203e-09	66.0	COG0454@1|root,COG0456@2|Bacteria,1V4RP@1239|Firmicutes,4HHSD@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS2_k127_377852_0	273116.14325254	5.445e-184	583.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,241J8@183967|Thermoplasmata	183967|Thermoplasmata	F	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMS2_k127_377852_5	273116.14325044	6.129e-69	239.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,241JB@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMS2_k127_3780865_4	273075.Ta0145	5.006e-11	72.0	COG1175@1|root,arCOG00157@2157|Archaea,2XU7E@28890|Euryarchaeota,2427U@183967|Thermoplasmata	183967|Thermoplasmata	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17312	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	BPD_transp_1
MMS2_k127_3780865_3	439481.Aboo_0662	1.853e-15	86.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,3F2HS@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS2_k127_3780865_2	273075.Ta0146	5.643e-65	231.0	COG0395@1|root,arCOG00159@2157|Archaea,2Y3NJ@28890|Euryarchaeota,2428H@183967|Thermoplasmata	183967|Thermoplasmata	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17313	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	BPD_transp_1
MMS2_k127_3780865_0	273075.Ta0147	1.555e-107	362.0	COG3408@1|root,arCOG03287@2157|Archaea,2XU8W@28890|Euryarchaeota	28890|Euryarchaeota	G	N-terminal domain of (some) glycogen debranching enzymes	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
MMS2_k127_3780865_1	273075.Ta0143	8.763e-89	297.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MB@28890|Euryarchaeota,24216@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K17314	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	ABC_tran
MMS2_k127_3811121_12	273116.14325598	9.519e-35	135.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,241S7@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS2_k127_3811121_3	263820.PTO1361	2.43e-124	404.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,241Y9@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS2_k127_3811121_5	273116.14325594	2.46e-108	361.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_3811121_9	273116.14325593	7.101e-92	313.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_3811121_1	273116.14325592	1.551e-158	515.0	COG0444@1|root,arCOG00181@2157|Archaea,2XSTM@28890|Euryarchaeota	28890|Euryarchaeota	E	COG0444 ABC-type dipeptide oligopeptide nickel transport system ATPase component	oppD2	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_3811121_0	273116.14325591	1.22e-160	520.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota	28890|Euryarchaeota	E	COG4608 ABC-type oligopeptide transport system, ATPase component	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS2_k127_3811121_7	263820.PTO0517	4.165e-102	334.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS2_k127_3811121_13	263820.PTO0518	1.369e-25	118.0	COG1676@1|root,arCOG01701@2157|Archaea,2Y6AD@28890|Euryarchaeota,241VY@183967|Thermoplasmata	183967|Thermoplasmata	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity)	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo
MMS2_k127_3811121_14	5722.XP_001319879.1	9.79e-05	51.0	KOG0094@1|root,KOG0094@2759|Eukaryota	5722.XP_001319879.1|-	S	retrograde vesicle-mediated transport, Golgi to ER	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3811121_2	273116.14324619	1.306e-149	484.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,241ZA@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMS2_k127_3811121_10	273116.14324620	7.444e-72	254.0	COG1986@1|root,arCOG01221@2157|Archaea,2Y898@28890|Euryarchaeota,241PH@183967|Thermoplasmata	183967|Thermoplasmata	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,NTPase_I-T
MMS2_k127_3811121_11	263820.PTO0507	6.769e-51	181.0	COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,242AR@183967|Thermoplasmata	183967|Thermoplasmata	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS2_k127_3811121_8	273116.14325659	1.374e-101	332.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,241NQ@183967|Thermoplasmata	183967|Thermoplasmata	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMS2_k127_3811121_4	263820.PTO0505	1.166e-109	368.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,241NZ@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMS2_k127_3811121_6	273075.Ta0215	4.938e-104	342.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11781,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
MMS2_k127_381667_2	1246459.KB898355_gene4277	9.263e-51	188.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,2TUCW@28211|Alphaproteobacteria,4BNAM@82115|Rhizobiaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
MMS2_k127_381667_1	1123320.KB889675_gene4054	6.745e-144	471.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_381667_0	263820.PTO1196	1.236e-162	516.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,241MW@183967|Thermoplasmata	183967|Thermoplasmata	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMS2_k127_381667_3	263820.PTO1195	6.146e-18	85.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IM@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS2_k127_3859971_3	273116.14325440	5.733e-36	138.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,241QS@183967|Thermoplasmata	183967|Thermoplasmata	J	K homology RNA-binding domain	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
MMS2_k127_3859971_4	1041930.Mtc_0319	1.745e-08	64.0	COG1587@1|root,arCOG02048@2157|Archaea,2XTA1@28890|Euryarchaeota	28890|Euryarchaeota	H	Uroporphyrinogen-III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
MMS2_k127_3859971_1	273075.Ta0572	6.053e-74	258.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,241PT@183967|Thermoplasmata	183967|Thermoplasmata	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
MMS2_k127_3859971_0	634498.mru_0999	8.216e-119	394.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,23NIZ@183925|Methanobacteria	183925|Methanobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_3859971_2	273075.Ta0926	7.527e-59	216.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,241TB@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS2_k127_3859971_5	273075.Ta0551	2.429e-08	57.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,241N1@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
MMS2_k127_3863614_2	932678.THERU_00030	1.964e-09	62.0	COG0208@1|root,COG0208@2|Bacteria,2G3WB@200783|Aquificae	200783|Aquificae	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdF	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS2_k127_3863614_0	1501230.ET33_14890	2.947e-261	825.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,4H9X0@91061|Bacilli,26U46@186822|Paenibacillaceae	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
MMS2_k127_3863614_1	1120972.AUMH01000002_gene2669	1.359e-120	396.0	COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,4H9WX@91061|Bacilli	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS2_k127_3896411_1	263820.PTO0989	8.159e-78	267.0	COG1573@1|root,arCOG00905@2157|Archaea,2Y786@28890|Euryarchaeota,241YB@183967|Thermoplasmata	183967|Thermoplasmata	L	UreE urease accessory protein, C-terminal domain	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS2_k127_3896411_0	273075.Ta0495	4.206e-106	354.0	COG0498@1|root,arCOG01434@2157|Archaea,2XVBI@28890|Euryarchaeota,2423Z@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_3896411_3	273116.14325697	6.006e-18	89.0	COG2427@1|root,arCOG02113@2157|Archaea,2Y5ZD@28890|Euryarchaeota,242HP@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS2_k127_3896411_2	273116.14325698	1.714e-58	211.0	COG0446@1|root,arCOG01064@2157|Archaea,2XUFE@28890|Euryarchaeota,24203@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS2_k127_3906721_0	273116.14324237	3.571e-81	281.0	COG1814@1|root,arCOG01096@2157|Archaea,2XWEX@28890|Euryarchaeota,2423V@183967|Thermoplasmata	183967|Thermoplasmata	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
MMS2_k127_3906721_1	263820.PTO0848	2.802e-56	204.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,241XW@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS2_k127_3928822_1	263820.PTO0945	3.384e-27	123.0	COG0454@1|root,arCOG00846@2157|Archaea,2Y7B4@28890|Euryarchaeota,2429P@183967|Thermoplasmata	183967|Thermoplasmata	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_3928822_0	273116.14325556	7.921e-28	124.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y7B2@28890|Euryarchaeota,2429J@183967|Thermoplasmata	183967|Thermoplasmata	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4047748_0	273116.14324233	9.128e-186	594.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,241KQ@183967|Thermoplasmata	183967|Thermoplasmata	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS2_k127_4047748_1	1006006.Mcup_2000	1.686e-106	357.0	COG1055@1|root,arCOG00238@2157|Archaea	2157|Archaea	P	Citrate transporter	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
MMS2_k127_4054576_3	485913.Krac_1303	9.869e-16	84.0	COG4934@1|root,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	He_PIG,Peptidase_S8,Pro-kuma_activ
MMS2_k127_4054576_1	673860.AciM339_0730	1.35e-53	213.0	COG4934@1|root,arCOG05978@1|root,arCOG03669@2157|Archaea,arCOG05978@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F38G@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ,fn3
MMS2_k127_4054576_0	273116.14324677	4.772e-78	273.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,241SZ@183967|Thermoplasmata	183967|Thermoplasmata	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_3
MMS2_k127_4054576_2	439481.Aboo_0341	7.103e-29	121.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,3F3CD@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMS2_k127_4060329_0	273075.Ta0541	4.943e-84	290.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y695@28890|Euryarchaeota,241ZB@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_4060329_1	263820.PTO1045	6.969e-55	198.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,241N2@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS2_k127_4063957_2	1128421.JAGA01000003_gene3653	3.358e-51	193.0	COG3975@1|root,COG3975@2|Bacteria,2NQU3@2323|unclassified Bacteria	2|Bacteria	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
MMS2_k127_4063957_3	263820.PTO0908	1.859e-46	174.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,241VB@183967|Thermoplasmata	183967|Thermoplasmata	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
MMS2_k127_4063957_0	273075.Ta1104	6.318e-169	535.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,241KB@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
MMS2_k127_4063957_1	273116.14324672	7.791e-137	444.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,241JM@183967|Thermoplasmata	183967|Thermoplasmata	G	4-hydroxy-tetrahydrodipicolinate reductase	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
MMS2_k127_4141096_2	572478.Vdis_0835	2.077e-37	145.0	COG0454@1|root,arCOG00826@2157|Archaea,2XR3W@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_4141096_0	273075.Ta0456m	2.57e-192	608.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,241JH@183967|Thermoplasmata	183967|Thermoplasmata	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
MMS2_k127_4141096_1	273075.Ta1311	1.059e-49	179.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,241K5@183967|Thermoplasmata	183967|Thermoplasmata	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
MMS2_k127_4142694_3	263820.PTO0601	2.414e-42	162.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,241WG@183967|Thermoplasmata	183967|Thermoplasmata	E	GHMP kinases N terminal domain	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
MMS2_k127_4142694_4	572546.Arcpr_0877	5.721e-29	126.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,2464B@183980|Archaeoglobi	183980|Archaeoglobi	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS2_k127_4142694_2	273075.Ta0285	4.847e-60	221.0	COG0337@1|root,arCOG00983@2157|Archaea,2XY3B@28890|Euryarchaeota,2427G@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
MMS2_k127_4142694_0	273116.14325577	8.525e-234	738.0	COG3387@1|root,arCOG03286@2157|Archaea,2XUKJ@28890|Euryarchaeota,2421E@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyl hydrolases family 15	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
MMS2_k127_4142694_1	273075.Ta0040	7.523e-200	640.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,241KT@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_4195132_3	263820.PTO1256	2.981e-66	235.0	COG0294@1|root,arCOG02817@2157|Archaea,2XTGI@28890|Euryarchaeota,241P1@183967|Thermoplasmata	183967|Thermoplasmata	H	Mur ligase family, glutamate ligase domain	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
MMS2_k127_4195132_1	273116.14324985	4.599e-141	460.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,241NW@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
MMS2_k127_4195132_5	273075.Ta0875	1.875e-26	115.0	COG1280@1|root,arCOG01947@2157|Archaea,2XURC@28890|Euryarchaeota,24285@183967|Thermoplasmata	183967|Thermoplasmata	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
MMS2_k127_4195132_2	415426.Hbut_0983	5.168e-115	377.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS2_k127_4195132_0	263820.PTO1000	3.829e-253	795.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2422K@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS2_k127_4195132_4	273116.14324493	8.61e-51	184.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,241SP@183967|Thermoplasmata	183967|Thermoplasmata	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
MMS2_k127_4199826_1	273075.Ta0907	1.339e-185	591.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,241KW@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA polymerase type-B family	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
MMS2_k127_4199826_2	273116.14325026	1.232e-106	358.0	COG0112@1|root,arCOG00070@2157|Archaea,2XX80@28890|Euryarchaeota,2420Y@183967|Thermoplasmata	183967|Thermoplasmata	H	Serine hydroxymethyltransferase	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS2_k127_4199826_0	263820.PTO0862	1.388e-192	627.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,24243@183967|Thermoplasmata	183967|Thermoplasmata	E	Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids	trf2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS2_k127_4199826_3	263820.PTO0944	1.514e-90	309.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,241V4@183967|Thermoplasmata	183967|Thermoplasmata	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
MMS2_k127_4199826_5	273116.14325559	1.78e-62	218.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,241UN@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMS2_k127_4199826_4	273116.14324668	4.577e-68	239.0	COG0026@1|root,arCOG01597@2157|Archaea,2XSY3@28890|Euryarchaeota,2425D@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
MMS2_k127_4208569_0	673860.AciM339_0322	8.649e-166	532.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,3F2EU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMS2_k127_423392_1	263820.PTO0987	2.192e-79	273.0	COG0025@1|root,arCOG01961@2157|Archaea,2XT52@28890|Euryarchaeota,24223@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS2_k127_423392_0	673860.AciM339_0009	2.12e-134	445.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F2TI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS2_k127_423392_2	673860.AciM339_0008	6.002e-26	113.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F37F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS2_k127_4257878_9	273075.Ta0591	3.136e-08	59.0	COG0433@1|root,arCOG04034@2157|Archaea,2Y7QK@28890|Euryarchaeota,242BW@183967|Thermoplasmata	183967|Thermoplasmata	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMS2_k127_4257878_8	263820.PTO0458	2.467e-10	64.0	arCOG05340@1|root,arCOG05340@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4257878_4	273116.14325181	6.037e-88	297.0	COG0842@1|root,arCOG01467@2157|Archaea,2XU41@28890|Euryarchaeota,24227@183967|Thermoplasmata	183967|Thermoplasmata	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_4257878_2	273075.Ta0869	4.671e-122	399.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUK9@28890|Euryarchaeota,241QH@183967|Thermoplasmata	183967|Thermoplasmata	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS2_k127_4257878_5	263820.PTO0129	5.188e-80	269.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,241PW@183967|Thermoplasmata	183967|Thermoplasmata	F	nicotinamide-nucleotide adenylyltransferase activity	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS2_k127_4257878_1	273116.14325342	6.177e-143	464.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,241MR@183967|Thermoplasmata	183967|Thermoplasmata	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS2_k127_4257878_0	515635.Dtur_0830	2.599e-144	472.0	COG0441@1|root,COG0441@2|Bacteria	2|Bacteria	J	threonyl-tRNA aminoacylation	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMS2_k127_4257878_7	263820.PTO1365	6.553e-47	177.0	COG0560@1|root,arCOG01158@2157|Archaea,2Y79H@28890|Euryarchaeota,241UM@183967|Thermoplasmata	183967|Thermoplasmata	E	haloacid dehalogenase-like hydrolase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
MMS2_k127_4257878_6	263820.PTO0229	1.55e-75	260.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,241QP@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity)	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
MMS2_k127_4257878_3	263820.PTO0228	2.543e-104	347.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,241MU@183967|Thermoplasmata	183967|Thermoplasmata	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMS2_k127_4259357_2	263820.PTO1191	1.439e-48	175.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,241JC@183967|Thermoplasmata	183967|Thermoplasmata	J	leucyl-tRNA aminoacylation	leuS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_4259357_1	273075.Ta0778	2.748e-76	259.0	COG1945@1|root,arCOG04490@2157|Archaea,2XY3V@28890|Euryarchaeota,24249@183967|Thermoplasmata	183967|Thermoplasmata	E	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
MMS2_k127_4259357_3	273116.14325178	3.037e-10	66.0	COG1371@1|root,arCOG04055@2157|Archaea,2Y6BE@28890|Euryarchaeota,242CD@183967|Thermoplasmata	183967|Thermoplasmata	J	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
MMS2_k127_4259357_0	273075.Ta0670	1.206e-306	943.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,241JK@183967|Thermoplasmata	183967|Thermoplasmata	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_4266498_3	273116.14324599	4.773e-15	83.0	arCOG07404@1|root,arCOG07404@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4266498_1	760142.Hipma_0406	1.54e-88	304.0	COG0863@1|root,COG0863@2|Bacteria,1PCSY@1224|Proteobacteria,43A4T@68525|delta/epsilon subdivisions,2WYRP@28221|Deltaproteobacteria,2M7NX@213113|Desulfurellales	28221|Deltaproteobacteria	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
MMS2_k127_4266498_2	273075.Ta1078	8.469e-41	164.0	COG0436@1|root,arCOG04334@2157|Archaea,2Y7JJ@28890|Euryarchaeota,242DD@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMS2_k127_4266498_5	263820.PTO1507	1.021e-07	57.0	COG1030@1|root,arCOG01910@2157|Archaea	2157|Archaea	O	Membrane-bound serine protease (ClpP class)	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
MMS2_k127_4266498_0	273116.14324269	1.665e-161	530.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,241UP@183967|Thermoplasmata	183967|Thermoplasmata	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS2_k127_4266498_4	273116.14324267	1.689e-14	74.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,241TN@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS2_k127_4282734_1	273116.14324614	1.517e-34	134.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79,1.2.1.8	ko:K00128,ko:K00130,ko:K00135	ko00010,ko00053,ko00071,ko00250,ko00260,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00260,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135,M00555	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_4282734_2	263820.PTO0890	3.291e-26	115.0	COG0500@1|root,arCOG02702@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
MMS2_k127_4282734_0	1041930.Mtc_0248	4.846e-42	160.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
MMS2_k127_4316628_0	1460634.JCM19037_1835	7.472e-50	192.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4HA2A@91061|Bacilli	91061|Bacilli	I	acyl-CoA dehydrogenase	mmgC	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_4316628_1	273075.Ta0362	1.344e-16	91.0	arCOG07369@1|root,arCOG07369@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_432464_1	263820.PTO0557	2.99e-65	231.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,241RI@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS2_k127_432464_2	263820.PTO0619	1.641e-41	159.0	COG2150@1|root,arCOG02317@2157|Archaea,2XYHC@28890|Euryarchaeota,242BH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
MMS2_k127_432464_0	273075.Ta0057m	3.307e-194	623.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,241VX@183967|Thermoplasmata	183967|Thermoplasmata	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
MMS2_k127_432464_3	273075.Ta0058	1.551e-05	48.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,241VK@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS2_k127_432464_4	273116.14324228	0.0001614	44.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,241VK@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS2_k127_4335356_0	263820.PTO1442	1.248e-79	280.0	COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,2420W@183967|Thermoplasmata	183967|Thermoplasmata	G	MOFRL family	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMS2_k127_4335356_3	1198232.CYCME_2222	5.351e-20	94.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,1RN27@1236|Gammaproteobacteria,460KK@72273|Thiotrichales	72273|Thiotrichales	P	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_4335356_1	1218108.KB908294_gene2118	1.092e-55	199.0	COG1443@1|root,COG1443@2|Bacteria,4NFJV@976|Bacteroidetes,1HXIQ@117743|Flavobacteriia	976|Bacteroidetes	I	Isopentenyl-diphosphate delta-isomerase	idi	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
MMS2_k127_4335356_2	263820.PTO1506	8.303e-49	179.0	COG1611@1|root,arCOG02431@2157|Archaea,2XXTK@28890|Euryarchaeota,24289@183967|Thermoplasmata	183967|Thermoplasmata	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
MMS2_k127_4343895_1	273116.14324255	1.865e-25	107.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y4MS@28890|Euryarchaeota,242C9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4343895_3	1096546.WYO_4312	7.543e-05	51.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,1JUVF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS2_k127_4343895_0	263820.PTO0624	4.113e-49	177.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,242A6@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS2_k127_4343895_2	589924.Ferp_1723	3.466e-21	95.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,245SF@183980|Archaeoglobi	183980|Archaeoglobi	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMS2_k127_4377862_2	273116.14325443	1.148e-54	195.0	COG0195@1|root,arCOG01760@2157|Archaea,2Y6CG@28890|Euryarchaeota,241TM@183967|Thermoplasmata	183967|Thermoplasmata	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	-
MMS2_k127_4377862_1	273116.14325444	1.446e-180	578.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,241KY@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
MMS2_k127_4377862_0	273075.Ta0391	0.0	1178.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,241IQ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS2_k127_4384150_1	1341151.ASZU01000004_gene347	4.884e-96	321.0	COG3185@1|root,COG3185@2|Bacteria,1UZP2@1239|Firmicutes,4HDQI@91061|Bacilli,27B5H@186824|Thermoactinomycetaceae	91061|Bacilli	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
MMS2_k127_4384150_2	218284.CCDN010000002_gene2113	2.473e-68	243.0	COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,1ZCD1@1386|Bacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
MMS2_k127_4384150_0	263820.PTO1371	1.613e-127	416.0	COG3508@1|root,arCOG06976@2157|Archaea	2157|Archaea	C	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
MMS2_k127_4397517_3	1123312.KB904585_gene771	4.201e-18	88.0	COG1670@1|root,COG1670@2|Bacteria,1V7MA@1239|Firmicutes	1239|Firmicutes	J	Acetyltransferase GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3,Acetyltransf_4
MMS2_k127_4397517_0	273116.14324395	3.26e-72	251.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,241QT@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS2_k127_4397517_2	273116.14324393	7.906e-40	154.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2429R@183967|Thermoplasmata	183967|Thermoplasmata	S	ZPR1 zinc-finger domain	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
MMS2_k127_4397517_1	867845.KI911784_gene3606	3.42e-52	194.0	COG3975@1|root,COG3975@2|Bacteria,2GAB7@200795|Chloroflexi,374W2@32061|Chloroflexia	32061|Chloroflexia	S	SMART PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
MMS2_k127_4399210_1	1038867.AXAY01000016_gene1818	1.591e-87	295.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JQYS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	cobZ	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
MMS2_k127_4399210_3	1345697.M493_10740	2.707e-59	219.0	COG1149@1|root,COG1149@2|Bacteria,1VSNV@1239|Firmicutes	1239|Firmicutes	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4399210_0	1041147.AUFB01000020_gene5427	1.281e-122	409.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B7AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_4399210_2	756499.Desde_0810	3.6e-79	285.0	COG0028@1|root,COG0028@2|Bacteria,1TSBQ@1239|Firmicutes,24YTB@186801|Clostridia,264KR@186807|Peptococcaceae	186801|Clostridia	EH	Belongs to the TPP enzyme family	-	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS2_k127_4399210_4	264198.Reut_C6210	2.333e-34	140.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2VX9A@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100,Peptidase_S9
MMS2_k127_4401403_1	1459636.NTE_00049	8.238e-43	163.0	COG2062@1|root,arCOG01992@2157|Archaea	2157|Archaea	T	TIGRFAM phosphohistidine phosphatase SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
MMS2_k127_4401403_0	273075.Ta0056	4.476e-60	213.0	COG0461@1|root,arCOG00029@2157|Archaea,2XVNG@28890|Euryarchaeota,241R4@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMS2_k127_4412489_5	273075.Ta0022	1.622e-68	242.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,241QQ@183967|Thermoplasmata	183967|Thermoplasmata	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMS2_k127_4412489_4	263820.PTO0564	2.16e-92	314.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2424F@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_4412489_3	263820.PTO0563	4.046e-130	424.0	COG3367@1|root,arCOG02828@2157|Archaea,2XTPS@28890|Euryarchaeota,24244@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
MMS2_k127_4412489_2	273116.14324286	6.868e-144	470.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,241ZP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4412489_7	273116.14324289	1.244e-47	176.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,241V7@183967|Thermoplasmata	183967|Thermoplasmata	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
MMS2_k127_4412489_1	673860.AciM339_0284	2.542e-206	655.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,3F2HU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMS2_k127_4412489_8	273116.14324248	6.116e-28	115.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y0F9@28890|Euryarchaeota,241WX@183967|Thermoplasmata	183967|Thermoplasmata	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS2_k127_4412489_0	273075.Ta0036m	0.0	1326.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,241KH@183967|Thermoplasmata	183967|Thermoplasmata	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
MMS2_k127_4412489_6	263820.PTO0620	1.628e-62	218.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,241NA@183967|Thermoplasmata	183967|Thermoplasmata	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
MMS2_k127_4418328_1	263820.PTO0544	1.403e-53	194.0	COG2096@1|root,arCOG00489@2157|Archaea,2XTKK@28890|Euryarchaeota,2425V@183967|Thermoplasmata	183967|Thermoplasmata	H	Cobalamin adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Cob_adeno_trans
MMS2_k127_4418328_2	404380.Gbem_0707	4.597e-27	119.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS2_k127_4418328_0	273116.14324312	3.4e-87	294.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,2423A@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS2_k127_4422169_11	263820.PTO0566	1.707e-15	79.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,2423S@183967|Thermoplasmata	183967|Thermoplasmata	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
MMS2_k127_4422169_5	273116.14324397	8.27e-48	181.0	COG0491@1|root,arCOG00511@2157|Archaea,2Y3Q7@28890|Euryarchaeota,2428Y@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_4422169_0	273116.14325530	2.059e-229	726.0	COG0365@1|root,arCOG01529@2157|Archaea,2XTEH@28890|Euryarchaeota	28890|Euryarchaeota	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acs1	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS2_k127_4422169_1	273116.14325760	1.714e-114	415.0	COG4934@1|root,arCOG03665@2157|Archaea	2157|Archaea	O	tripeptidyl-peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
MMS2_k127_4422169_12	671065.MetMK1DRAFT_00015180	2.656e-05	59.0	arCOG06052@1|root,arCOG06052@2157|Archaea,2XSHA@28889|Crenarchaeota	28889|Crenarchaeota	S	parallel beta-helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4422169_2	273116.14325631	3.065e-96	324.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,24233@183967|Thermoplasmata	183967|Thermoplasmata	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_4422169_4	273075.Ta0226	2.462e-61	220.0	COG0842@1|root,arCOG01467@2157|Archaea,2XT3B@28890|Euryarchaeota,2429G@183967|Thermoplasmata	183967|Thermoplasmata	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_4422169_8	263820.PTO0871	1.655e-26	111.0	COG4847@1|root,arCOG00317@2157|Archaea,2Y4P1@28890|Euryarchaeota,242CH@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized protein conserved in archaea (DUF2175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2175
MMS2_k127_4422169_10	1121090.KB894685_gene3412	4.086e-18	97.0	COG2271@1|root,COG2271@2|Bacteria,1V0VC@1239|Firmicutes,4HC5B@91061|Bacilli,1ZD8A@1386|Bacillus	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4422169_3	263820.PTO0627	1.488e-95	318.0	COG0708@1|root,arCOG02207@2157|Archaea,2XVJ5@28890|Euryarchaeota,241XM@183967|Thermoplasmata	183967|Thermoplasmata	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
MMS2_k127_4422169_7	273116.14325275	9.347e-29	121.0	COG3439@1|root,arCOG02761@2157|Archaea,2Y7BY@28890|Euryarchaeota,242F7@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
MMS2_k127_4422169_9	273116.14325611	2.807e-23	103.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y01N@28890|Euryarchaeota,242D9@183967|Thermoplasmata	183967|Thermoplasmata	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
MMS2_k127_4422169_6	273116.14325151	8.248e-34	134.0	COG0596@1|root,arCOG01648@2157|Archaea,2XY7B@28890|Euryarchaeota,242EV@183967|Thermoplasmata	183967|Thermoplasmata	E	Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS2_k127_4454015_0	195522.BD01_1095	7.191e-76	266.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243RX@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_4454015_2	263820.PTO0023	6.279e-11	69.0	arCOG08351@1|root,arCOG08351@2157|Archaea,2XZR4@28890|Euryarchaeota	28890|Euryarchaeota	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
MMS2_k127_4454015_1	572547.Amico_1651	4.07e-36	147.0	COG2362@1|root,COG2362@2|Bacteria,3TAU4@508458|Synergistetes	508458|Synergistetes	E	PFAM peptidase M55 D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
MMS2_k127_4454015_3	321846.PS417_05005	0.0006373	44.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
MMS2_k127_4485404_1	1123405.AUMM01000036_gene121	1.249e-10	63.0	COG0406@1|root,COG0406@2|Bacteria,1V7F8@1239|Firmicutes,4HIR1@91061|Bacilli	91061|Bacilli	G	Phosphoglycerate mutase	gpmA1	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
MMS2_k127_4485404_0	189426.PODO_21640	1.571e-21	102.0	COG0262@1|root,COG0262@2|Bacteria,1V4F8@1239|Firmicutes,4HGWK@91061|Bacilli,26WNW@186822|Paenibacillaceae	91061|Bacilli	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
MMS2_k127_4535412_2	273063.STK_00730	1.336e-76	261.0	arCOG07343@1|root,arCOG07343@2157|Archaea,2XS2D@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4535412_0	1128398.Curi_c29370	1.05e-225	729.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,26AM4@186813|unclassified Clostridiales	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA2	-	1.17.1.10,1.17.1.11,1.17.1.9	ko:K00123,ko:K05299,ko:K22341	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS2_k127_4535412_1	768679.TTX_1270	2.731e-105	354.0	COG1894@1|root,COG1905@1|root,arCOG04537@2157|Archaea,arCOG04890@2157|Archaea,2XRQD@28889|Crenarchaeota	28889|Crenarchaeota	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
MMS2_k127_4579464_0	273116.14325124	7.268e-79	284.0	COG2244@1|root,arCOG02209@2157|Archaea,2Y7AT@28890|Euryarchaeota,24273@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
MMS2_k127_4579464_1	273075.Ta0336	2.48e-07	53.0	arCOG03678@1|root,arCOG03677@2157|Archaea,2Y0K5@28890|Euryarchaeota,242AH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4586820_0	673860.AciM339_0102	1.049e-131	430.0	COG1228@1|root,arCOG00696@2157|Archaea,2XVAU@28890|Euryarchaeota,3F2Z2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
MMS2_k127_4586820_1	1033802.SSPSH_000101	1.597e-21	98.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
MMS2_k127_4613760_1	1123296.JQKE01000024_gene1310	4.858e-43	167.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,2KPU4@206351|Neisseriales	206351|Neisseriales	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS2_k127_4613760_0	637389.Acaty_c1146	1.843e-72	257.0	COG0226@1|root,COG0226@2|Bacteria,1R9S4@1224|Proteobacteria,1SJT9@1236|Gammaproteobacteria,2NCGA@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS2_k127_4627743_0	263820.PTO0127	2.899e-68	248.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7A7@28890|Euryarchaeota,241ZW@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4627743_1	273063.STK_00890	1.432e-09	63.0	COG3370@1|root,arCOG01668@2157|Archaea,2XS6U@28889|Crenarchaeota	28889|Crenarchaeota	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
MMS2_k127_4629005_2	273116.14325643	9.683e-23	98.0	COG1032@1|root,arCOG01364@2157|Archaea,2XVND@28890|Euryarchaeota,2423G@183967|Thermoplasmata	183967|Thermoplasmata	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS2_k127_4629005_0	273116.14325698	1.184e-147	476.0	COG0446@1|root,arCOG01064@2157|Archaea,2XUFE@28890|Euryarchaeota,24203@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
MMS2_k127_4629005_3	1307436.PBF_11452	0.0002185	50.0	COG2427@1|root,COG2427@2|Bacteria,1VDZ4@1239|Firmicutes,4HP7W@91061|Bacilli,1ZDHJ@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS2_k127_4629005_1	525904.Tter_1226	1.299e-52	190.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
MMS2_k127_465603_2	273116.14325302	1.505e-45	167.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,241V3@183967|Thermoplasmata	183967|Thermoplasmata	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
MMS2_k127_465603_1	273116.14324587	2.988e-99	332.0	COG2513@1|root,arCOG00581@2157|Archaea,2Y86J@28890|Euryarchaeota,241XC@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
MMS2_k127_465603_0	273116.14324588	3.307e-142	465.0	COG2079@1|root,arCOG04285@2157|Archaea,2XTMT@28890|Euryarchaeota,2426I@183967|Thermoplasmata	183967|Thermoplasmata	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
MMS2_k127_465603_3	1173027.Mic7113_1234	4.704e-20	102.0	COG1808@1|root,COG1808@2|Bacteria,1GCGN@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
MMS2_k127_465603_4	1406840.Q763_15990	1.558e-10	63.0	COG3476@1|root,COG3476@2|Bacteria,4NP0D@976|Bacteroidetes,1I2B8@117743|Flavobacteriia,2NVX1@237|Flavobacterium	976|Bacteroidetes	T	TspO/MBR family	tspO	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
MMS2_k127_4662151_1	273116.14324798	2.155e-63	227.0	COG0515@1|root,arCOG07377@2157|Archaea	2157|Archaea	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4662151_2	56110.Oscil6304_3815	2.4e-16	89.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
MMS2_k127_4662151_0	273116.14324796	9.347e-85	288.0	arCOG07379@1|root,arCOG07379@2157|Archaea	2157|Archaea	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4681721_0	565033.GACE_0502	1.415e-16	88.0	COG1216@1|root,arCOG01383@2157|Archaea,2Y668@28890|Euryarchaeota,247A7@183980|Archaeoglobi	183980|Archaeoglobi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_4681721_1	929506.CbC4_0593	5.921e-05	54.0	COG4106@1|root,COG4106@2|Bacteria,1V21K@1239|Firmicutes,24G2Z@186801|Clostridia,36Q3T@31979|Clostridiaceae	186801|Clostridia	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_31
MMS2_k127_4681721_2	1298865.H978DRAFT_3553	0.0005947	51.0	COG4106@1|root,COG4106@2|Bacteria,1QWK2@1224|Proteobacteria,1T3XF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
MMS2_k127_4704084_0	323259.Mhun_0175	2.415e-104	355.0	COG1672@1|root,arCOG03166@2157|Archaea,2XTP2@28890|Euryarchaeota,2N9VA@224756|Methanomicrobia	224756|Methanomicrobia	S	ATPase domain predominantly from Archaea	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2,DUF234
MMS2_k127_4704084_2	749927.AMED_0836	1.163e-40	156.0	COG1309@1|root,COG1309@2|Bacteria,2I31S@201174|Actinobacteria,4E4MZ@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
MMS2_k127_4704084_1	1356854.N007_14445	3.313e-59	214.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
MMS2_k127_4744347_0	263820.PTO0162	7.483e-160	517.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4744347_1	1429046.RR21198_5160	3.116e-06	54.0	COG1846@1|root,COG1846@2|Bacteria,2IBDP@201174|Actinobacteria,4G14N@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
MMS2_k127_4745648_6	263820.PTO0972	1.051e-14	79.0	arCOG06971@1|root,arCOG06971@2157|Archaea,2Y24Q@28890|Euryarchaeota,242H0@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4745648_7	273116.14324872	1.928e-08	64.0	COG0206@1|root,arCOG02201@2157|Archaea	2157|Archaea	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	Tubulin
MMS2_k127_4745648_3	273116.14324847	8.865e-58	204.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,241SX@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
MMS2_k127_4745648_1	273116.14324846	6.006e-118	388.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,241J0@183967|Thermoplasmata	183967|Thermoplasmata	F	aspartate carbamoyltransferase activity	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS2_k127_4745648_0	273075.Ta0406m	3.518e-160	515.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,241X1@183967|Thermoplasmata	183967|Thermoplasmata	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	1.1.1.34,1.1.1.88	ko:K00021,ko:K00054	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02081,R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
MMS2_k127_4745648_5	263820.PTO1142	3.327e-34	140.0	COG0457@1|root,arCOG03045@2157|Archaea,2Y3R1@28890|Euryarchaeota,2429D@183967|Thermoplasmata	183967|Thermoplasmata	S	tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4745648_4	273075.Ta0459	8.806e-35	138.0	COG3612@1|root,arCOG04418@2157|Archaea,2Y7B7@28890|Euryarchaeota,242A8@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
MMS2_k127_4745648_2	273116.14325318	5.883e-77	263.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,24220@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
MMS2_k127_4754610_1	985053.VMUT_1168	1.203e-109	369.0	COG0160@1|root,arCOG00915@2157|Archaea,2XPTE@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_4754610_4	387631.Asulf_01626	4.178e-21	105.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS2_k127_4754610_0	273116.14325545	2.291e-165	532.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota	28890|Euryarchaeota	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2542	Aldedh
MMS2_k127_4754610_3	316274.Haur_4401	7.669e-38	153.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS2_k127_4754610_2	273063.STK_18520	3.161e-85	296.0	arCOG03660@1|root,arCOG03660@2157|Archaea,2XRM5@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4801930_2	589924.Ferp_1128	9.116e-31	124.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,245UR@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS2_k127_4801930_3	671143.DAMO_2493	9.296e-23	100.0	COG2329@1|root,COG2329@2|Bacteria,2NS2V@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	isdG	-	1.14.99.48,1.14.99.57	ko:K07145,ko:K21481	ko00860,ko01110,map00860,map01110	-	R10468,R10510	RC03185	ko00000,ko00001,ko01000	-	-	-	ABM
MMS2_k127_4801930_1	439481.Aboo_1462	3.665e-44	184.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
MMS2_k127_4801930_0	273116.14324434	1.081e-48	188.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS2_k127_4825321_3	374847.Kcr_0256	3.157e-15	80.0	COG1748@1|root,arCOG00243@2157|Archaea	2157|Archaea	E	Saccharopine dehydrogenase	-	-	1.4.1.18,1.5.1.7	ko:K00290,ko:K19064	ko00300,ko00310,ko00960,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00960,map01100,map01110,map01130,map01230	M00030,M00032	R00446,R00715,R02317	RC00062,RC00217,RC00694,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
MMS2_k127_4825321_0	273063.STK_25420	8.109e-86	295.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPN5@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	dppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_4825321_1	768672.Desfe_0661	1.923e-75	264.0	COG4608@1|root,arCOG00184@2157|Archaea,2XPUA@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_4825321_2	572478.Vdis_1379	8.876e-36	150.0	COG0747@1|root,arCOG01534@2157|Archaea,2XPZY@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_482603_5	273075.Ta0858	4.444e-10	65.0	COG1052@1|root,arCOG01755@2157|Archaea,2XZQ9@28890|Euryarchaeota,24272@183967|Thermoplasmata	183967|Thermoplasmata	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_482603_2	263820.PTO0568	4.036e-137	445.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,241PD@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
MMS2_k127_482603_3	263820.PTO0630	9.423e-73	256.0	COG0697@1|root,arCOG00271@2157|Archaea,2XVTF@28890|Euryarchaeota,2427P@183967|Thermoplasmata	183967|Thermoplasmata	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS2_k127_482603_1	273116.14325763	4.013e-172	560.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,241KS@183967|Thermoplasmata	183967|Thermoplasmata	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
MMS2_k127_482603_0	273116.14325764	1.01e-244	768.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,241KJ@183967|Thermoplasmata	183967|Thermoplasmata	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
MMS2_k127_482603_4	273075.Ta1491	8.05e-29	116.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,241VC@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4849290_1	273116.14324469	1.534e-125	411.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,241Y5@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4849290_0	263820.PTO1241	1.301e-319	994.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,241MT@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
MMS2_k127_4849290_4	273075.Ta1231	2.004e-28	122.0	COG3413@1|root,arCOG02271@2157|Archaea,2Y7BN@28890|Euryarchaeota,242D2@183967|Thermoplasmata	183967|Thermoplasmata	K	HTH DNA binding domain	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS2_k127_4849290_2	876269.ARWA01000001_gene2010	2.649e-70	244.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,2U6AD@28211|Alphaproteobacteria,3NAPF@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	O-methyltransferase	mdmC	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
MMS2_k127_4849290_3	263820.PTO1067	8.162e-50	180.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,24255@183967|Thermoplasmata	183967|Thermoplasmata	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMS2_k127_4860810_0	632335.Calkr_0337	6.142e-188	603.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
MMS2_k127_4860810_1	1443665.JACA01000005_gene524	2.707e-05	56.0	COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NFNN@976|Bacteroidetes,1IINK@117743|Flavobacteriia,2YI2M@290174|Aquimarina	976|Bacteroidetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,TPR_12,TPR_8
MMS2_k127_4881218_6	273116.14324482	4.479e-07	58.0	arCOG05382@1|root,arCOG05382@2157|Archaea,2Y5Z0@28890|Euryarchaeota,242HQ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4881218_0	386456.JQKN01000002_gene2482	1.943e-180	587.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota	28890|Euryarchaeota	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
MMS2_k127_4881218_2	273075.Ta0823	2.667e-40	156.0	COG0406@1|root,arCOG01991@2157|Archaea,2Y23H@28890|Euryarchaeota,2428S@183967|Thermoplasmata	183967|Thermoplasmata	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
MMS2_k127_4881218_3	273116.14325051	1.347e-38	149.0	COG1956@1|root,arCOG05374@2157|Archaea,2Y497@28890|Euryarchaeota,242AW@183967|Thermoplasmata	183967|Thermoplasmata	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
MMS2_k127_4881218_4	273075.Ta0505	2.787e-21	106.0	arCOG03290@1|root,arCOG03290@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4881218_7	273075.Ta0503a	1.386e-05	53.0	arCOG07381@1|root,arCOG07381@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4881218_1	273075.Ta0503	3.969e-105	363.0	COG0531@1|root,arCOG00009@2157|Archaea	2157|Archaea	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease,AA_permease_2
MMS2_k127_4881218_5	386456.JQKN01000001_gene2189	6.372e-16	78.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,23NUS@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
MMS2_k127_4884567_2	1120971.AUCA01000005_gene2247	4.477e-70	259.0	COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,4HA4X@91061|Bacilli,2782I@186823|Alicyclobacillaceae	91061|Bacilli	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
MMS2_k127_4884567_4	999630.TUZN_1073	1.097e-14	79.0	COG1622@1|root,arCOG01235@2157|Archaea,2XR96@28889|Crenarchaeota	28889|Crenarchaeota	C	Cytochrome C oxidase subunit II	soxH	-	1.10.3.12,1.9.3.1	ko:K02275,ko:K02826	ko00190,ko01100,map00190,map01100	M00155,M00416	R00081,R09492	RC00016,RC00819	ko00000,ko00001,ko00002,ko01000	3.D.4.1,3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
MMS2_k127_4884567_1	273116.14324581	3.59e-157	518.0	COG0348@1|root,arCOG03697@2157|Archaea	2157|Archaea	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4884567_0	263820.PTO0807	7.499e-193	607.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,241M4@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
MMS2_k127_4884567_3	273116.14324541	7.1e-38	147.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,241RB@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS2_k127_4885073_1	273116.14324338	1.751e-194	618.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,24240@183967|Thermoplasmata	183967|Thermoplasmata	G	Sugar (and other) transporter	-	-	-	ko:K08176	-	-	-	-	ko00000,ko02000	2.A.1.9	-	-	Sugar_tr
MMS2_k127_4885073_3	273075.Ta0113	4.704e-138	451.0	COG1171@1|root,arCOG01431@2157|Archaea,2XT4W@28890|Euryarchaeota,2420P@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
MMS2_k127_4885073_6	273116.14324234	2.923e-19	90.0	COG1254@1|root,arCOG01674@2157|Archaea,2Y7C5@28890|Euryarchaeota,242G3@183967|Thermoplasmata	183967|Thermoplasmata	C	acylphosphatase activity	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMS2_k127_4885073_0	263820.PTO0744	6.784e-197	620.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,241JZ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
MMS2_k127_4885073_2	273116.14324230	5.555e-144	472.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,241IY@183967|Thermoplasmata	183967|Thermoplasmata	F	AICARFT/IMPCHase bienzyme	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
MMS2_k127_4885073_5	273116.14324232	1.207e-70	250.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2427H@183967|Thermoplasmata	183967|Thermoplasmata	S	Presenilin, signal peptide peptidase, family	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMS2_k127_4885073_4	273116.14324233	1.183e-80	274.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,241KQ@183967|Thermoplasmata	183967|Thermoplasmata	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS2_k127_4886553_10	273116.14325595	2.146e-87	310.0	COG0747@1|root,arCOG01533@2157|Archaea,2Y7AQ@28890|Euryarchaeota,2426H@183967|Thermoplasmata	183967|Thermoplasmata	P	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
MMS2_k127_4886553_14	1236689.MMALV_02990	1.337e-52	194.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,3F2JY@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_1,KH_6,S1
MMS2_k127_4886553_3	273075.Ta1293	9.745e-111	362.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,241MB@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS2_k127_4886553_4	273116.14324526	3.231e-108	355.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,241N4@183967|Thermoplasmata	183967|Thermoplasmata	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS2_k127_4886553_17	263820.PTO0392	1.071e-35	136.0	COG1997@1|root,arCOG04208@2157|Archaea,2Y6HP@28890|Euryarchaeota,241TV@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMS2_k127_4886553_6	273116.14324528	6.223e-104	349.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,241NT@183967|Thermoplasmata	183967|Thermoplasmata	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
MMS2_k127_4886553_18	263820.PTO0389	9.968e-33	129.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,241X7@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMS2_k127_4886553_20	273116.14324530	3.779e-14	76.0	COG1460@1|root,arCOG01016@2157|Archaea,2Y5MB@28890|Euryarchaeota,242FB@183967|Thermoplasmata	183967|Thermoplasmata	K	RNA polymerase	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMS2_k127_4886553_11	273075.Ta1299	2.145e-81	274.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,241Q5@183967|Thermoplasmata	183967|Thermoplasmata	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMS2_k127_4886553_16	263820.PTO0386	5.43e-47	179.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,241VH@183967|Thermoplasmata	183967|Thermoplasmata	J	Ribosomal RNA adenine dimethylases	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMS2_k127_4886553_7	263820.PTO0385	1.751e-103	343.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,241RS@183967|Thermoplasmata	183967|Thermoplasmata	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS2_k127_4886553_12	673860.AciM339_0169	1.088e-68	241.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,3F38W@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Phosphoribosyl transferase domain	-	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
MMS2_k127_4886553_9	439481.Aboo_0039	1.161e-87	299.0	COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,3F2X1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Amino acid kinase family	cpkA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS2_k127_4886553_5	273075.Ta0174	9.809e-108	355.0	COG2107@1|root,arCOG00654@2157|Archaea,2XWEB@28890|Euryarchaeota,242FT@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
MMS2_k127_4886553_21	1280692.AUJL01000008_gene2415	4.077e-08	65.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,36DK7@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	gapN	-	1.2.1.9	ko:K00131	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_4886553_0	273075.Ta0117	4.649e-195	617.0	COG0538@1|root,arCOG01164@2157|Archaea,2XTAR@28890|Euryarchaeota,241T3@183967|Thermoplasmata	183967|Thermoplasmata	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS2_k127_4886553_1	273075.Ta1367m	5.615e-135	442.0	COG0104@1|root,arCOG04387@2157|Archaea,2XT59@28890|Euryarchaeota,241IP@183967|Thermoplasmata	183967|Thermoplasmata	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMS2_k127_4886553_8	368408.Tpen_0040	5.099e-96	324.0	COG0492@1|root,arCOG01296@2157|Archaea,2XPSW@28889|Crenarchaeota	28889|Crenarchaeota	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
MMS2_k127_4886553_15	273116.14324873	5.736e-50	181.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX9F@28890|Euryarchaeota,242E7@183967|Thermoplasmata	183967|Thermoplasmata	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMS2_k127_4886553_2	273075.Ta0609m	8.216e-118	386.0	COG0017@1|root,arCOG00409@2157|Archaea,2XUPE@28890|Euryarchaeota,241Y0@183967|Thermoplasmata	183967|Thermoplasmata	J	tRNA synthetases class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
MMS2_k127_4886553_13	273075.Ta0069	1.771e-54	198.0	COG1591@1|root,arCOG00919@2157|Archaea,2XY2Q@28890|Euryarchaeota,241SS@183967|Thermoplasmata	183967|Thermoplasmata	L	Archaeal holliday junction resolvase (hjc)	-	-	-	-	-	-	-	-	-	-	-	-	Hjc
MMS2_k127_4886553_19	273116.14324238	1.029e-31	126.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2421R@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_4948291_5	273116.14324966	1.811e-30	131.0	COG0210@1|root,arCOG00798@2157|Archaea,2Y7QM@28890|Euryarchaeota,2420G@183967|Thermoplasmata	183967|Thermoplasmata	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS2_k127_4948291_8	273116.14324513	1.012e-19	90.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y6GC@28890|Euryarchaeota,242F4@183967|Thermoplasmata	183967|Thermoplasmata	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS2_k127_4948291_4	224719.Abm4_0488	1.526e-44	169.0	COG2078@1|root,arCOG01336@2157|Archaea,2XUAP@28890|Euryarchaeota,23PJV@183925|Methanobacteria	183925|Methanobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
MMS2_k127_4948291_3	263820.PTO0958	4.237e-62	223.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,241T1@183967|Thermoplasmata	183967|Thermoplasmata	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMS2_k127_4948291_0	273116.14325615	5.475e-147	471.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,241PG@183967|Thermoplasmata	183967|Thermoplasmata	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMS2_k127_4948291_2	1041930.Mtc_1660	4.18e-71	251.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMS2_k127_4948291_10	485913.Krac_0590	3.66e-14	77.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS2_k127_4948291_7	268407.PWYN_17460	6.196e-25	114.0	COG0842@1|root,COG0842@2|Bacteria,1V13R@1239|Firmicutes,4HD1H@91061|Bacilli,26U7M@186822|Paenibacillaceae	91061|Bacilli	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_4948291_6	1476876.JOJO01000012_gene4156	4.625e-28	123.0	COG0842@1|root,COG0842@2|Bacteria,2HDDD@201174|Actinobacteria	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_4948291_1	1157632.AQWQ01000003_gene2066	1.313e-102	343.0	COG1131@1|root,COG1131@2|Bacteria,2GTNE@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS2_k127_4948291_9	1380390.JIAT01000011_gene2749	6.96e-17	82.0	COG1247@1|root,COG1247@2|Bacteria,2II0A@201174|Actinobacteria	201174|Actinobacteria	M	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4950636_2	263820.PTO0019	2.998e-62	226.0	COG1680@1|root,arCOG00771@2157|Archaea	2157|Archaea	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
MMS2_k127_4950636_0	1118054.CAGW01000082_gene3042	1.313e-175	566.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,26TMF@186822|Paenibacillaceae	91061|Bacilli	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
MMS2_k127_4950636_1	263820.PTO0020	6.797e-94	324.0	COG1472@1|root,arCOG04634@2157|Archaea,2XTGV@28890|Euryarchaeota	28890|Euryarchaeota	G	COG1472 Beta-glucosidase-related glycosidases	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
MMS2_k127_4950636_3	673860.AciM339_0035	2.63e-09	67.0	arCOG00828@1|root,arCOG00828@2157|Archaea,2Y6YR@28890|Euryarchaeota,3F2XN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4965498_1	263820.PTO1199	6.395e-90	303.0	COG0142@1|root,arCOG01726@2157|Archaea,2XT85@28890|Euryarchaeota,241QG@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS2_k127_4965498_0	263820.PTO0225	4.32e-205	650.0	COG1012@1|root,arCOG01252@2157|Archaea,2XUKB@28890|Euryarchaeota,2421F@183967|Thermoplasmata	183967|Thermoplasmata	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_4965498_2	263820.PTO0187	1.213e-40	171.0	COG4934@1|root,arCOG03665@2157|Archaea,2Y1PU@28890|Euryarchaeota,241Z3@183967|Thermoplasmata	183967|Thermoplasmata	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMS2_k127_4984059_3	273075.Ta1118	1.022e-35	141.0	arCOG06011@1|root,arCOG06011@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
MMS2_k127_4984059_1	272844.PAB0762	7.617e-105	362.0	COG1505@1|root,arCOG01647@2157|Archaea,2XTRD@28890|Euryarchaeota,243RD@183968|Thermococci	183968|Thermococci	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
MMS2_k127_4984059_2	1408473.JHXO01000005_gene1726	1.263e-74	254.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,2FN7E@200643|Bacteroidia	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
MMS2_k127_4984059_4	84531.JMTZ01000030_gene139	7.575e-19	99.0	COG3214@1|root,COG3214@2|Bacteria,1R9AI@1224|Proteobacteria	1224|Proteobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS2_k127_4984059_0	273116.14324522	1.372e-115	375.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,241MX@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMS2_k127_4984059_5	660470.Theba_1359	0.0001027	53.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1700,DUF4097
MMS2_k127_5002155_1	273116.14325706	6.892e-67	241.0	arCOG05338@1|root,arCOG05338@2157|Archaea,2Y1WT@28890|Euryarchaeota,24288@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_5002155_0	273075.Ta1425	1.076e-86	295.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,241QW@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
MMS2_k127_5002155_2	273075.Ta1426m	1.046e-20	92.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y6IT@28890|Euryarchaeota,241W4@183967|Thermoplasmata	183967|Thermoplasmata	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
MMS2_k127_5016722_1	1280671.AUJH01000026_gene407	1.685e-92	312.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,4BXKQ@830|Butyrivibrio	186801|Clostridia	E	Aminotransferase class-V	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS2_k127_5016722_2	273075.Ta0204	3.339e-78	276.0	COG0719@1|root,arCOG01715@2157|Archaea,2Y3DN@28890|Euryarchaeota,2426Z@183967|Thermoplasmata	183967|Thermoplasmata	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
MMS2_k127_5016722_0	273116.14325655	8.495e-250	777.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,241R3@183967|Thermoplasmata	183967|Thermoplasmata	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
MMS2_k127_5016722_3	273116.14325656	4.681e-53	188.0	COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,241QJ@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
MMS2_k127_5022663_0	368407.Memar_0788	1.675e-12	71.0	arCOG07473@1|root,arCOG07473@2157|Archaea,2Y1CW@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_518383_1	273116.14325531	2.452e-37	143.0	COG1960@1|root,arCOG01707@2157|Archaea,2XSVA@28890|Euryarchaeota,2421G@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_518383_0	273116.14324692	4.98e-69	246.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,241U8@183967|Thermoplasmata	183967|Thermoplasmata	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMS2_k127_518383_2	263820.PTO1363	3.413e-10	61.0	COG2235@1|root,arCOG03108@2157|Archaea,2XX08@28890|Euryarchaeota,241XU@183967|Thermoplasmata	183967|Thermoplasmata	E	Amidinotransferase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
MMS2_k127_532834_1	273116.14325499	1.196e-160	517.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,241JJ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMS2_k127_532834_3	263820.PTO0780	1.022e-50	189.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,241WS@183967|Thermoplasmata	183967|Thermoplasmata	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMS2_k127_532834_2	263820.PTO1193	2.229e-81	281.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUCU@28890|Euryarchaeota,2421U@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_532834_0	273075.Ta0481	3.798e-200	637.0	COG1028@1|root,arCOG01259@2157|Archaea	2157|Archaea	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS2_k127_543337_2	591019.Shell_0921	0.0001742	47.0	COG1820@1|root,arCOG00699@2157|Archaea,2XPM6@28889|Crenarchaeota	28889|Crenarchaeota	G	N-acetylglucosamine-6-phosphate deacetylase	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS2_k127_543337_0	374847.Kcr_1516	1.491e-27	124.0	COG0449@1|root,arCOG00057@2157|Archaea	2157|Archaea	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
MMS2_k127_543337_1	263820.PTO0017	1.84e-08	59.0	COG0791@1|root,2N59G@2157|Archaea,2XWZY@28890|Euryarchaeota	28890|Euryarchaeota	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,SH3_3
MMS2_k127_548276_0	273116.14325569	9.059e-34	136.0	COG1960@1|root,arCOG01707@2157|Archaea,2Y3XS@28890|Euryarchaeota,242BF@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
MMS2_k127_548276_2	263820.PTO0330	3.413e-12	70.0	COG2383@1|root,arCOG04811@2157|Archaea,2Y5ZI@28890|Euryarchaeota,242G1@183967|Thermoplasmata	183967|Thermoplasmata	S	FUN14 family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_548276_1	1262449.CP6013_3017	2.625e-20	103.0	COG4986@1|root,COG4986@2|Bacteria,1TRRR@1239|Firmicutes,248X4@186801|Clostridia,36H6A@31979|Clostridiaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
MMS2_k127_559343_3	263820.PTO0396	8.473e-18	93.0	COG1468@1|root,arCOG00790@2157|Archaea	2157|Archaea	L	CRISPR-associated protein Cas4	-	GO:0000014,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0032392,GO:0032508,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0048037,GO:0051276,GO:0051536,GO:0051537,GO:0051540,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4,PDDEXK_1
MMS2_k127_559343_0	273116.14325624	1.966e-65	238.0	COG1473@1|root,arCOG01108@2157|Archaea,2XUUS@28890|Euryarchaeota,2423B@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
MMS2_k127_559343_1	696369.KI912183_gene43	2.213e-53	203.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia	1239|Firmicutes	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS2_k127_559343_2	562970.Btus_0899	5.422e-44	172.0	COG2271@1|root,COG2271@2|Bacteria,1VXZM@1239|Firmicutes,4HXI8@91061|Bacilli,27A6K@186823|Alicyclobacillaceae	91061|Bacilli	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_569390_2	273116.14324586	1.148e-05	53.0	COG1290@1|root,arCOG01721@2157|Archaea,2XVE0@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1290 Cytochrome b subunit of the bc complex	petB2	-	-	ko:K15879	-	-	-	-	ko00000	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS2_k127_569390_1	273116.14324580	2.395e-55	212.0	arCOG06974@1|root,arCOG06974@2157|Archaea,2Y4TI@28890|Euryarchaeota,242C1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_569390_0	1237500.ANBA01000009_gene1044	3.047e-60	224.0	COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4EGXC@85012|Streptosporangiales	201174|Actinobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS2_k127_569572_0	263820.PTO0856	4.283e-126	428.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,241K1@183967|Thermoplasmata	183967|Thermoplasmata	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS2_k127_575439_2	673860.AciM339_0757	7.884e-12	68.0	arCOG05351@1|root,arCOG05351@2157|Archaea,2Y1XZ@28890|Euryarchaeota,3F3DZ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF3198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3198
MMS2_k127_575439_0	273075.Ta0355	1.399e-122	398.0	COG0421@1|root,arCOG00050@2157|Archaea,2XV5K@28890|Euryarchaeota,2422Q@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
MMS2_k127_575439_1	273075.Ta0093	5.762e-35	136.0	COG0776@1|root,arCOG05336@2157|Archaea,2XZF7@28890|Euryarchaeota,242BD@183967|Thermoplasmata	183967|Thermoplasmata	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS2_k127_614097_1	399549.Msed_1781	3.477e-62	222.0	COG0555@1|root,arCOG00164@2157|Archaea,2XQTS@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15496	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	BPD_transp_1
MMS2_k127_614097_4	1229520.ADIAL_0341	1.31e-12	75.0	COG1136@1|root,COG1136@2|Bacteria,1TQP5@1239|Firmicutes,4HBXK@91061|Bacilli,27G0W@186828|Carnobacteriaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_614097_2	1237149.C900_04763	7.517e-38	146.0	COG0346@1|root,COG0346@2|Bacteria,4NN6H@976|Bacteroidetes,47SAE@768503|Cytophagia	976|Bacteroidetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
MMS2_k127_614097_0	517418.Ctha_0729	1.808e-68	243.0	COG1090@1|root,COG1090@2|Bacteria,1FDN7@1090|Chlorobi	1090|Chlorobi	S	PFAM NAD-dependent epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
MMS2_k127_614097_3	273075.Ta1315	2.909e-13	70.0	COG0036@1|root,arCOG05046@2157|Archaea,2XVS8@28890|Euryarchaeota,241QM@183967|Thermoplasmata	183967|Thermoplasmata	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMS2_k127_620372_1	269797.Mbar_A3302	2.114e-55	200.0	COG1335@1|root,arCOG01943@2157|Archaea,2Y0WZ@28890|Euryarchaeota,2NA9S@224756|Methanomicrobia	224756|Methanomicrobia	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS2_k127_620372_7	267377.MMP0574	0.0006651	42.0	arCOG06624@1|root,arCOG06624@2157|Archaea	2157|Archaea	-	-	rpl41e	-	-	ko:K02928	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
MMS2_k127_620372_0	673860.AciM339_1044	6.897e-62	244.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
MMS2_k127_620372_4	263820.PTO0774	1.297e-15	92.0	arCOG06052@1|root,arCOG06052@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB
MMS2_k127_620372_2	497964.CfE428DRAFT_3868	1.578e-53	203.0	COG4447@1|root,COG4447@2|Bacteria,46VQN@74201|Verrucomicrobia	74201|Verrucomicrobia	G	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
MMS2_k127_620372_5	485913.Krac_9399	2.456e-10	66.0	COG0346@1|root,COG0346@2|Bacteria,2G9N2@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
MMS2_k127_620372_3	1541960.KQ78_01442	7.236e-28	118.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
MMS2_k127_652735_1	913865.DOT_5185	6.994e-16	80.0	COG3797@1|root,COG3797@2|Bacteria,1V4KG@1239|Firmicutes,24UEG@186801|Clostridia,262DI@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
MMS2_k127_652735_0	1298598.JCM21714_1402	1.059e-123	404.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS2_k127_693203_0	263820.PTO0332	2.492e-196	619.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,24237@183967|Thermoplasmata	183967|Thermoplasmata	C	NADP-dependent dehydrogenase of the nED (non- phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D- glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3- phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006081,GO:0006082,GO:0006090,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009255,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016620,GO:0016903,GO:0019637,GO:0019682,GO:0019752,GO:0022607,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0043796,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0061678,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901575	1.2.1.89	ko:K18128	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R10615	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_693203_1	263820.PTO0336	2.824e-106	358.0	COG0469@1|root,arCOG04120@2157|Archaea,2XU34@28890|Euryarchaeota,24224@183967|Thermoplasmata	183967|Thermoplasmata	F	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
MMS2_k127_707238_1	273075.Ta1479m	1.746e-122	398.0	COG0489@1|root,arCOG00585@2157|Archaea,2XTU2@28890|Euryarchaeota,241MZ@183967|Thermoplasmata	183967|Thermoplasmata	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
MMS2_k127_707238_3	273116.14325479	2.447e-42	160.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242AC@183967|Thermoplasmata	183967|Thermoplasmata	F	HIT domain	-	-	3.6.1.17	ko:K01518,ko:K02503	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT
MMS2_k127_707238_2	273116.14325480	1.055e-90	301.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,2421I@183967|Thermoplasmata	183967|Thermoplasmata	F	nucleoside metabolic process	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMS2_k127_707238_0	263820.PTO0466	1.443e-184	589.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,241IT@183967|Thermoplasmata	183967|Thermoplasmata	J	lysyl-tRNA aminoacylation	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMS2_k127_707238_4	263820.PTO0419	7.627e-30	123.0	COG1765@1|root,arCOG03685@2157|Archaea,2Y05H@28890|Euryarchaeota,242AT@183967|Thermoplasmata	183967|Thermoplasmata	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
MMS2_k127_707238_5	263820.PTO1272	1.265e-06	51.0	arCOG05400@1|root,arCOG05400@2157|Archaea,2Y4Y7@28890|Euryarchaeota,242CG@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_71790_4	273116.14324577	1.005e-18	89.0	arCOG05359@1|root,arCOG05359@2157|Archaea,2Y4J3@28890|Euryarchaeota,242CB@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1940)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1940
MMS2_k127_71790_3	263820.PTO0737	2.322e-58	213.0	COG0451@1|root,arCOG03016@2157|Archaea,2Y6ZK@28890|Euryarchaeota,2428Z@183967|Thermoplasmata	183967|Thermoplasmata	M	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
MMS2_k127_71790_0	273075.Ta0351	3.881e-240	746.0	COG0183@1|root,arCOG01280@2157|Archaea,2Y85P@28890|Euryarchaeota,241YR@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_71790_2	273116.14325521	2.349e-80	272.0	COG1545@1|root,arCOG01287@2157|Archaea,2Y7AV@28890|Euryarchaeota,2427M@183967|Thermoplasmata	183967|Thermoplasmata	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS2_k127_71790_1	263820.PTO0736	1.126e-85	291.0	COG1351@1|root,arCOG01884@2157|Archaea,2Y7AA@28890|Euryarchaeota,2420S@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	-	-	-	-	-	-	-	-	-	-	-	-	Thy1
MMS2_k127_724594_3	263820.PTO1308	1.045e-12	68.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,241MS@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS2_k127_724594_0	273075.Ta0952	2.747e-150	481.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2421M@183967|Thermoplasmata	183967|Thermoplasmata	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
MMS2_k127_724594_1	273063.STK_11490	4.452e-80	274.0	COG3342@1|root,arCOG04204@2157|Archaea,2XQSJ@28889|Crenarchaeota	28889|Crenarchaeota	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
MMS2_k127_724594_2	269797.Mbar_A2985	5.365e-24	114.0	COG0668@1|root,arCOG01568@2157|Archaea,2XSU5@28890|Euryarchaeota	28890|Euryarchaeota	M	COG0668 Small-conductance mechanosensitive channel	mscS1	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
MMS2_k127_749984_1	263820.PTO0613	1.535e-77	263.0	COG0421@1|root,arCOG00050@2157|Archaea,2XV5K@28890|Euryarchaeota,2422Q@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
MMS2_k127_749984_3	273075.Ta0354	2.336e-13	74.0	arCOG05351@1|root,arCOG05351@2157|Archaea,2Y1XZ@28890|Euryarchaeota,242GE@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF3198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3198
MMS2_k127_749984_2	273116.14325539	2.524e-55	199.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,241VI@183967|Thermoplasmata	183967|Thermoplasmata	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS2_k127_749984_0	263820.PTO0374	9.539e-152	492.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,241KF@183967|Thermoplasmata	183967|Thermoplasmata	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22
MMS2_k127_764546_1	572478.Vdis_1942	2.441e-42	167.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS2_k127_764546_0	397948.Cmaq_0910	8.489e-126	409.0	COG0714@1|root,arCOG00434@2157|Archaea,2XPMH@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS2_k127_803449_1	266117.Rxyl_0010	7.217e-37	149.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_803449_0	1379698.RBG1_1C00001G0452	1.806e-85	289.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
MMS2_k127_833748_3	273116.14325006	6.134e-26	110.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,24200@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
MMS2_k127_833748_2	273116.14324887	1.568e-37	143.0	COG0393@1|root,arCOG02287@2157|Archaea,2XYRF@28890|Euryarchaeota,2429W@183967|Thermoplasmata	183967|Thermoplasmata	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
MMS2_k127_833748_0	263820.PTO0603	4.909e-152	498.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,241MK@183967|Thermoplasmata	183967|Thermoplasmata	J	DALR anticodon binding domain	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	DALR_1,tRNA-synt_1d
MMS2_k127_833748_1	263820.PTO0602	9.162e-76	269.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,241VD@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS2_k127_856730_7	1007103.AFHW01000036_gene1823	4.537e-28	115.0	COG0454@1|root,COG0456@2|Bacteria,1V50M@1239|Firmicutes,4HH63@91061|Bacilli,26XZ2@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) family	yqjY	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	-	ko:K06977	-	-	-	-	ko00000	-	-	-	Acetyltransf_1
MMS2_k127_856730_0	273116.14325620	5.562e-299	924.0	COG2987@1|root,arCOG04670@2157|Archaea,2XT9Q@28890|Euryarchaeota,24215@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMS2_k127_856730_8	1459636.NTE_00024	2.083e-14	78.0	COG5485@1|root,arCOG06513@2157|Archaea	2157|Archaea	S	ester cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
MMS2_k127_856730_4	649747.HMPREF0083_02280	6.171e-47	181.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
MMS2_k127_856730_10	1380390.JIAT01000011_gene2642	1.565e-11	73.0	2AV0E@1|root,31KQ8@2|Bacteria,2HPHG@201174|Actinobacteria,4CQVP@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_856730_5	391596.PBAL39_16896	3.761e-38	150.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
MMS2_k127_856730_9	1343739.PAP_07285	1.339e-13	83.0	arCOG04615@1|root,arCOG04615@2157|Archaea,2Y2IE@28890|Euryarchaeota,244Z1@183968|Thermococci	183968|Thermococci	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS2_k127_856730_6	671065.MetMK1DRAFT_00013170	5.689e-34	135.0	COG4911@1|root,arCOG05495@2157|Archaea,2XSGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
MMS2_k127_856730_1	593750.Metfor_0512	9.403e-121	400.0	COG0863@1|root,arCOG00129@2157|Archaea,arCOG00890@2157|Archaea,2XWFW@28890|Euryarchaeota,2NBA0@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS2_k127_856730_2	351627.Csac_0634	1.091e-72	254.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,42G63@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMS2_k127_856730_3	985053.VMUT_1872	8.217e-48	177.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_856730_12	985053.VMUT_0356	5.305e-06	53.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS2_k127_874118_1	439481.Aboo_1389	1.507e-56	200.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,3F2FP@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMS2_k127_874118_2	273075.Ta1243m	1.591e-32	137.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,241U5@183967|Thermoplasmata	183967|Thermoplasmata	J	snoRNA binding domain, fibrillarin	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMS2_k127_874118_0	263820.PTO0667	2.479e-111	369.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,241NC@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	PUA,TruB_C_2,TruB_N
MMS2_k127_874118_3	439481.Aboo_1495	3.724e-26	111.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,3F3AN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMS2_k127_875281_4	309800.C498_19229	9.672e-11	64.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,23SUK@183963|Halobacteria	183963|Halobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
MMS2_k127_875281_1	263820.PTO0198	5.375e-54	191.0	COG4738@1|root,arCOG04377@2157|Archaea,2XZEC@28890|Euryarchaeota,2428A@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_875281_2	273116.14324841	2.061e-33	132.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,241U7@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterised protein family (UPF0147)	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMS2_k127_875281_3	263820.PTO0200	1.375e-24	106.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	asnC1	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS2_k127_875281_0	263820.PTO1428	1.252e-192	635.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota,241Q8@183967|Thermoplasmata	183967|Thermoplasmata	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMS2_k127_880986_9	436308.Nmar_0623	5.591e-08	64.0	arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
MMS2_k127_880986_5	273116.14324348	2.716e-64	222.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS2_k127_880986_2	572546.Arcpr_0145	4.467e-90	310.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,245TY@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_880986_0	273075.Ta1455	1.24e-188	595.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,241IW@183967|Thermoplasmata	183967|Thermoplasmata	I	transferase activity, transferring acyl groups	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C
MMS2_k127_880986_1	273075.Ta1430	6.073e-141	456.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,241T0@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMS2_k127_880986_7	273075.Ta1431	9.212e-40	156.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,241R2@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
MMS2_k127_880986_6	263820.PTO0436	1.785e-40	158.0	COG2045@1|root,arCOG04871@2157|Archaea,2Y673@28890|Euryarchaeota,2429Z@183967|Thermoplasmata	183967|Thermoplasmata	H	2-phosphosulfolactate phosphatase activity	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
MMS2_k127_880986_4	273116.14324639	2.352e-66	229.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,241RW@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS2_k127_880986_3	263820.PTO0438	4.862e-78	267.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,241NX@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
MMS2_k127_880986_8	263820.PTO0439	1.012e-15	79.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,241SB@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
MMS2_k127_900385_10	273116.14324434	7.601e-24	104.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS2_k127_900385_3	1316927.ATKI01000046_gene678	9.103e-121	409.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1S04I@1236|Gammaproteobacteria,1YPFG@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
MMS2_k127_900385_9	797209.ZOD2009_19388	8.697e-34	139.0	COG2820@1|root,arCOG01324@2157|Archaea,2Y06F@28890|Euryarchaeota,23W2X@183963|Halobacteria	183963|Halobacteria	F	Uridine phosphorylase	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
MMS2_k127_900385_7	273116.14324970	9.265e-44	163.0	COG1832@1|root,arCOG04227@2157|Archaea,2XXS6@28890|Euryarchaeota,242BJ@183967|Thermoplasmata	183967|Thermoplasmata	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
MMS2_k127_900385_8	263820.PTO0894	5.151e-43	158.0	COG1594@1|root,arCOG00579@2157|Archaea,2XXU7@28890|Euryarchaeota,241WZ@183967|Thermoplasmata	183967|Thermoplasmata	K	C2C2 Zinc finger	-	-	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
MMS2_k127_900385_1	273075.Ta0515	6.624e-189	599.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,241J3@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS2_k127_900385_0	263820.PTO0896	3.915e-216	675.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS2_k127_900385_11	439481.Aboo_0579	5.89e-22	96.0	COG2768@1|root,arCOG02448@2157|Archaea,2Y7JX@28890|Euryarchaeota,3F2W9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_900385_5	263820.PTO0898	1.609e-68	239.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,241RZ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMS2_k127_900385_4	263820.PTO0798	1.795e-109	373.0	COG1361@1|root,arCOG02089@2157|Archaea,2Y2K3@28890|Euryarchaeota,2422R@183967|Thermoplasmata	183967|Thermoplasmata	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_900385_2	273116.14324732	3.46e-178	570.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_900385_6	273057.SSO2571	1.352e-61	219.0	COG1489@1|root,arCOG04115@2157|Archaea,2XQDZ@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM Sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
MMS2_k127_909508_0	273075.Ta0309	1.488e-93	314.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,241JR@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMS2_k127_909508_2	263820.PTO1068	1.118e-57	216.0	COG0500@1|root,arCOG05015@2157|Archaea,2XX0Y@28890|Euryarchaeota,2427E@183967|Thermoplasmata	183967|Thermoplasmata	Q	RNA cap guanine-N2 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_909508_1	273116.14324789	7.096e-77	262.0	COG0807@1|root,arCOG01321@2157|Archaea,2XVGI@28890|Euryarchaeota,24234@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
MMS2_k127_909508_3	263820.PTO1070	3.346e-30	121.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota,24209@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner- Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.360	ko:K18124	ko00030,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00052,map01100,map01110,map01130,map01200	-	R01096,R07147	RC00066	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
MMS2_k127_974740_0	273075.Ta1119	1.535e-60	213.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,241N6@183967|Thermoplasmata	183967|Thermoplasmata	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
MMS2_k127_974740_1	1094508.Tsac_1090	4.051e-42	163.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.5	ko:K07025,ko:K08723	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
## 1197 queries scanned
## Total time (seconds): 77.6648645401001
## Rate: 15.41 q/s