## Fri Nov 15 06:44:39 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin17/MMS_2_bin.79.fa -m mmseqs --itype genome -o MMS_2_bin.79 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/MMS_2_bin.79 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
MMS2_k127_1020308_0	1227360.C176_07907	8.451e-59	211.0	COG3393@1|root,COG3393@2|Bacteria,1V9KV@1239|Firmicutes,4HJ79@91061|Bacilli,26HFA@186818|Planococcaceae	91061|Bacilli	S	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
MMS2_k127_1020308_3	1227454.C446_09970	6.306e-16	82.0	COG1487@1|root,arCOG02219@2157|Archaea,2XZ1Z@28890|Euryarchaeota,23WY3@183963|Halobacteria	183963|Halobacteria	V	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
MMS2_k127_1020308_4	694430.Natoc_0959	2.703e-07	55.0	arCOG08146@1|root,arCOG08146@2157|Archaea	2157|Archaea	S	Putative antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	VAPB_antitox
MMS2_k127_1020308_1	273116.14325461	1.319e-46	172.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Chromate resistance	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
MMS2_k127_1020308_2	189753.AXAS01000002_gene5413	1.57e-31	135.0	COG3391@1|root,COG3391@2|Bacteria,1RFWG@1224|Proteobacteria,2U7T8@28211|Alphaproteobacteria,3K2MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1051715_2	273075.Ta0618	1.562e-110	364.0	COG3959@1|root,arCOG01053@2157|Archaea,2XT88@28890|Euryarchaeota,241MN@183967|Thermoplasmata	183967|Thermoplasmata	G	1-deoxy-D-xylulose-5-phosphate synthase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
MMS2_k127_1051715_1	273075.Ta0617	6.366e-143	459.0	COG3958@1|root,arCOG01051@2157|Archaea,2Y86K@28890|Euryarchaeota,241IF@183967|Thermoplasmata	183967|Thermoplasmata	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS2_k127_1051715_3	1304875.JAFZ01000001_gene1332	1e-68	240.0	COG0176@1|root,COG0176@2|Bacteria,3TA7M@508458|Synergistetes	508458|Synergistetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
MMS2_k127_1051715_0	273116.14324879	4.255e-318	983.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,241KZ@183967|Thermoplasmata	183967|Thermoplasmata	S	KH domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
MMS2_k127_1051715_4	273075.Ta0612	7.201e-54	192.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,241Q3@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMS2_k127_105449_0	273116.14324423	5.322e-80	289.0	COG0383@1|root,arCOG03661@2157|Archaea,2XVNX@28890|Euryarchaeota,241Z5@183967|Thermoplasmata	183967|Thermoplasmata	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38
MMS2_k127_105449_1	399549.Msed_1126	1.471e-44	169.0	COG1802@1|root,arCOG06044@2157|Archaea	2157|Archaea	K	PFAM regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS2_k127_105449_2	273075.Ta1395	3.396e-28	117.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAS@28890|Euryarchaeota	28890|Euryarchaeota	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
MMS2_k127_1088953_0	1122182.KB903814_gene3132	5.516e-173	569.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2GJKW@201174|Actinobacteria,4DHEU@85008|Micromonosporales	201174|Actinobacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
MMS2_k127_1088953_2	273075.Ta0271	3.467e-08	60.0	arCOG06961@1|root,arCOG06961@2157|Archaea,2Y5B9@28890|Euryarchaeota,242F3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1088953_1	273075.Ta0270	1.683e-116	391.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,24242@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K00400,ko:K02031,ko:K02032	ko00680,ko01100,ko01120,ko02024,map00680,map01100,map01120,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_1098801_1	273057.SSO0304	4.851e-85	287.0	COG2876@1|root,arCOG01049@2157|Archaea,2XQ1G@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM DAHP synthetase I	aroG	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS2_k127_1098801_0	273116.14325358	5.942e-92	307.0	COG0603@1|root,arCOG00039@2157|Archaea,2XTS7@28890|Euryarchaeota,241MS@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
MMS2_k127_1098801_2	273116.14325357	2.909e-37	145.0	COG0720@1|root,arCOG02172@2157|Archaea,2XXFY@28890|Euryarchaeota,241WN@183967|Thermoplasmata	183967|Thermoplasmata	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
MMS2_k127_1098801_4	263820.PTO0234	1.264e-17	88.0	arCOG06955@1|root,arCOG06955@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1098801_3	1169152.AXVD01000023_gene3257	4.367e-34	144.0	COG0477@1|root,COG0500@1|root,COG0477@2|Bacteria,COG2226@2|Bacteria,2HHY4@201174|Actinobacteria,4G1MV@85025|Nocardiaceae	201174|Actinobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_1098801_5	1056495.Calag_1003	4.39e-11	75.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1110552_3	1122152.AUEI01000008_gene471	4.581e-15	81.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,4HP0X@91061|Bacilli,3FCEG@33958|Lactobacillaceae	91061|Bacilli	P	Sodium/hydrogen exchanger family	napA	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
MMS2_k127_1110552_1	1173264.KI913949_gene709	1.378e-46	176.0	COG0235@1|root,COG0235@2|Bacteria,1G2EA@1117|Cyanobacteria,1H8JN@1150|Oscillatoriales	1117|Cyanobacteria	E	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)	mtnB	-	4.2.1.109	ko:K08964	ko00270,ko01100,map00270,map01100	M00034	R07392	RC01939	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
MMS2_k127_1110552_0	314230.DSM3645_20382	2.22e-62	219.0	COG1791@1|root,COG1791@2|Bacteria,2J2NB@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway	mtnD	-	1.13.11.53,1.13.11.54	ko:K08967	ko00270,ko01100,map00270,map01100	M00034	R07363,R07364	RC01866,RC02018,RC02118	ko00000,ko00001,ko00002,ko01000	-	-	-	ARD
MMS2_k127_1110552_2	7370.XP_005184485.1	7.004e-30	124.0	COG4229@1|root,KOG2630@2759|Eukaryota,398HV@33154|Opisthokonta,3BEY0@33208|Metazoa,3CV76@33213|Bilateria,41XV4@6656|Arthropoda,3SJNB@50557|Insecta,453CH@7147|Diptera	33208|Metazoa	E	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)	ENOPH1	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019509,GO:0019752,GO:0042578,GO:0043094,GO:0043102,GO:0043436,GO:0043874,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.77	ko:K09880	ko00270,ko01100,map00270,map01100	M00034	R07395	RC02779	ko00000,ko00001,ko00002,ko01000	-	-	-	Hydrolase
MMS2_k127_1125845_8	273057.SSO1064	1.455e-57	204.0	COG0041@1|root,arCOG02464@2157|Archaea,2XQST@28889|Crenarchaeota	28889|Crenarchaeota	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
MMS2_k127_1125845_4	273075.Ta1107	1.772e-103	347.0	COG0026@1|root,arCOG01597@2157|Archaea,2XSY3@28890|Euryarchaeota,2425D@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
MMS2_k127_1125845_6	273075.Ta0898	1.997e-80	276.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,241PA@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
MMS2_k127_1125845_0	263820.PTO1070	7.495e-139	450.0	COG1063@1|root,arCOG01459@2157|Archaea,2XT9P@28890|Euryarchaeota,24209@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner- Doudoroff pathway	gdh	GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575	1.1.1.360	ko:K18124	ko00030,ko00052,ko01100,ko01110,ko01130,ko01200,map00030,map00052,map01100,map01110,map01130,map01200	-	R01096,R07147	RC00066	ko00000,ko00001,ko01000	-	-	-	ADH_N,Glu_dehyd_C
MMS2_k127_1125845_5	273116.14324789	1.314e-81	275.0	COG0807@1|root,arCOG01321@2157|Archaea,2XVGI@28890|Euryarchaeota,24234@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
MMS2_k127_1125845_7	273116.14324788	1.431e-57	215.0	COG0500@1|root,arCOG05015@2157|Archaea,2XX0Y@28890|Euryarchaeota,2427E@183967|Thermoplasmata	183967|Thermoplasmata	Q	RNA cap guanine-N2 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1125845_3	273075.Ta0309	1.685e-106	353.0	COG0152@1|root,arCOG04421@2157|Archaea,2XTW4@28890|Euryarchaeota,241JR@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
MMS2_k127_1125845_10	273116.14324817	4.649e-37	143.0	arCOG05362@1|root,arCOG05362@2157|Archaea,2Y5IA@28890|Euryarchaeota,242EZ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1125845_11	273116.14324816	9.789e-31	126.0	arCOG05401@1|root,arCOG05401@2157|Archaea,2Y42P@28890|Euryarchaeota,242AN@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1125845_12	273116.14324875	4.69e-29	124.0	COG0417@1|root,arCOG00328@2157|Archaea	273116.14324875|-	L	DNA polymerase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1125845_9	273075.Ta0611	2.869e-45	169.0	COG0517@1|root,arCOG00606@2157|Archaea,2Y0BC@28890|Euryarchaeota,242A4@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_1125845_2	330779.Saci_1839	8.406e-123	413.0	COG0471@1|root,arCOG00237@2157|Archaea,2XQ6M@28889|Crenarchaeota	28889|Crenarchaeota	P	TrkA-C domain	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
MMS2_k127_1125845_13	694440.JOMF01000009_gene737	4.545e-24	109.0	arCOG05710@1|root,arCOG05710@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1125845_1	351160.RCIX132	3.696e-129	423.0	arCOG01917@1|root,arCOG01917@2157|Archaea,2XYA0@28890|Euryarchaeota	28890|Euryarchaeota	O	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,zinc_ribbon_2
MMS2_k127_1125845_14	356829.BITS_0219	0.0008864	51.0	COG1520@1|root,COG1520@2|Bacteria,2IBDZ@201174|Actinobacteria,4CYUA@85004|Bifidobacteriales	201174|Actinobacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,zinc_ribbon_2
MMS2_k127_113069_3	933801.Ahos_0324	1.144e-43	161.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRVS@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.76	ko:K15038	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R09280	RC00004,RC00184	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_113069_0	1448860.BBJO01000014_gene1409	5.362e-108	375.0	COG1501@1|root,arCOG03663@2157|Archaea,2XVVM@28890|Euryarchaeota,23UPD@183963|Halobacteria	183963|Halobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
MMS2_k127_113069_2	1121324.CLIT_5c01350	8.928e-58	212.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
MMS2_k127_113069_1	273075.Ta0619	1.272e-80	278.0	COG0329@1|root,arCOG04172@2157|Archaea,2Y2YX@28890|Euryarchaeota,2425H@183967|Thermoplasmata	183967|Thermoplasmata	E	Dihydrodipicolinate synthetase family	-	-	4.1.2.55	ko:K11395	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00309,M00633	R01064,R05605,R08570,R10616	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS2_k127_113069_4	1214101.BN159_1370	1.117e-20	99.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	MA20_13990	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	Lactamase_B
MMS2_k127_1156913_1	273075.Ta0079	1.125e-77	268.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y878@28890|Euryarchaeota,241QK@183967|Thermoplasmata	183967|Thermoplasmata	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
MMS2_k127_1156913_3	273116.14324510	1.017e-27	117.0	COG0735@1|root,arCOG01868@2157|Archaea,2Y1GV@28890|Euryarchaeota	28890|Euryarchaeota	P	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
MMS2_k127_1156913_0	273116.14325615	1.54e-132	430.0	COG1180@1|root,arCOG00946@2157|Archaea,2XUB7@28890|Euryarchaeota,241PG@183967|Thermoplasmata	183967|Thermoplasmata	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
MMS2_k127_1156913_2	273116.14325622	2.206e-58	210.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,241T1@183967|Thermoplasmata	183967|Thermoplasmata	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
MMS2_k127_1160992_2	263820.PTO1099	1.772e-07	54.0	arCOG05356@1|root,arCOG05356@2157|Archaea,2Y3A3@28890|Euryarchaeota,2421Y@183967|Thermoplasmata	183967|Thermoplasmata	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
MMS2_k127_1160992_0	263820.PTO0899	0.0	1147.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,241KM@183967|Thermoplasmata	183967|Thermoplasmata	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
MMS2_k127_1160992_1	263820.PTO0900	6.787e-81	278.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,241SQ@183967|Thermoplasmata	183967|Thermoplasmata	F	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
MMS2_k127_1161429_13	439481.Aboo_0624	1.26e-11	67.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y76C@28890|Euryarchaeota,3F3GR@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1161429_10	263820.PTO0874	1.001e-34	136.0	COG0073@1|root,arCOG01136@2157|Archaea,2Y4BV@28890|Euryarchaeota,2429X@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative tRNA binding domain	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
MMS2_k127_1161429_1	273075.Ta1464	9.138e-133	445.0	COG0038@1|root,arCOG02569@2157|Archaea,2XW6N@28890|Euryarchaeota,24226@183967|Thermoplasmata	183967|Thermoplasmata	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS2_k127_1161429_0	273075.Ta0057m	2.728e-206	659.0	COG1199@1|root,arCOG00770@2157|Archaea,2XTH2@28890|Euryarchaeota,241VX@183967|Thermoplasmata	183967|Thermoplasmata	L	HELICc2	-	-	3.6.4.12	ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,HBB,Helicase_C_2
MMS2_k127_1161429_9	273075.Ta0033	2.109e-37	148.0	COG2150@1|root,arCOG02317@2157|Archaea,2XYHC@28890|Euryarchaeota,242BH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
MMS2_k127_1161429_2	273116.14324509	6.763e-73	257.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,241RI@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS2_k127_1161429_6	273116.14324508	4.248e-50	187.0	arCOG07412@1|root,arCOG07412@2157|Archaea,2Y0S5@28890|Euryarchaeota,241XA@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1161429_5	263820.PTO0625	6.422e-51	186.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,241TF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
MMS2_k127_1161429_7	263820.PTO0624	2.873e-47	178.0	COG0509@1|root,arCOG01303@2157|Archaea,2XY1B@28890|Euryarchaeota,242A6@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
MMS2_k127_1161429_14	1220534.B655_1557	7.098e-10	67.0	COG1514@1|root,arCOG01736@2157|Archaea,2XZ2M@28890|Euryarchaeota,23P6A@183925|Methanobacteria	183925|Methanobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
MMS2_k127_1161429_11	273116.14324255	2.737e-24	105.0	arCOG05352@1|root,arCOG05352@2157|Archaea,2Y4MS@28890|Euryarchaeota,242C9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1161429_4	273116.14324406	3.048e-63	220.0	COG0640@1|root,arCOG05349@2157|Archaea,2XYUG@28890|Euryarchaeota,241TE@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1161429_12	273075.Ta0116	4.429e-21	102.0	COG0169@1|root,arCOG02097@2157|Archaea,2Y5JG@28890|Euryarchaeota,242HC@183967|Thermoplasmata	183967|Thermoplasmata	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
MMS2_k127_1161429_3	263820.PTO0597	3.342e-65	229.0	COG2095@1|root,arCOG01997@2157|Archaea,2XZEI@28890|Euryarchaeota,2426E@183967|Thermoplasmata	183967|Thermoplasmata	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
MMS2_k127_1161429_8	273075.Ta0018	7.701e-39	154.0	COG1392@1|root,arCOG02640@2157|Archaea,2Y493@28890|Euryarchaeota,242AA@183967|Thermoplasmata	183967|Thermoplasmata	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
MMS2_k127_1193011_2	330779.Saci_1769	1.102e-06	55.0	COG3511@1|root,arCOG05966@2157|Archaea,2XRK9@28889|Crenarchaeota	2157|Archaea	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
MMS2_k127_1193011_0	399549.Msed_1499	3.768e-26	118.0	arCOG03843@1|root,arCOG03844@2157|Archaea	2157|Archaea	S	Domain of unknown function (DUF929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF929
MMS2_k127_1193011_1	273075.Ta0084	9.807e-18	91.0	COG0467@1|root,arCOG01693@2157|Archaea	2157|Archaea	T	V4R	-	-	-	ko:K07013	-	-	-	-	ko00000	-	-	-	ATPase,V4R
MMS2_k127_1205209_1	263820.PTO1286	2.656e-49	179.0	COG1586@1|root,arCOG00279@2157|Archaea,2XXWH@28890|Euryarchaeota,242A3@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
MMS2_k127_1205209_2	273116.14324623	4.227e-44	169.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,24299@183967|Thermoplasmata	183967|Thermoplasmata	K	Regulatory protein Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	-
MMS2_k127_1205209_0	263820.PTO1260	4.69e-50	184.0	COG0321@1|root,arCOG01942@2157|Archaea	2157|Archaea	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS2_k127_1205209_3	273075.Ta1317	1.635e-11	70.0	arCOG05382@1|root,arCOG05382@2157|Archaea,2Y5Z0@28890|Euryarchaeota,242HQ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1238097_3	930945.SiRe_2499	1.102e-54	202.0	COG5424@1|root,arCOG06031@2157|Archaea,2XRWB@28889|Crenarchaeota	28889|Crenarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4,zf-C2H2_9
MMS2_k127_1238097_7	273116.14324735	2.074e-10	66.0	arCOG05391@1|root,arCOG05391@2157|Archaea,2Y53B@28890|Euryarchaeota,242H4@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1238097_1	273075.Ta1064	3.906e-58	209.0	COG1339@1|root,arCOG01904@2157|Archaea,2XTFW@28890|Euryarchaeota,241PC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN)	ribK	-	2.7.1.161	ko:K07732	ko00740,ko01100,map00740,map01100	-	R08574	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP-dep_RFKase,HTH_Crp_2
MMS2_k127_1238097_6	273116.14325082	3.965e-14	76.0	COG1412@1|root,arCOG04312@2157|Archaea,2Y0D4@28890|Euryarchaeota,242GQ@183967|Thermoplasmata	183967|Thermoplasmata	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
MMS2_k127_1238097_0	273116.14324870	5.874e-70	242.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,241R9@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
MMS2_k127_1238097_8	263820.PTO0972	2.117e-09	64.0	arCOG06971@1|root,arCOG06971@2157|Archaea,2Y24Q@28890|Euryarchaeota,242H0@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1238097_5	273116.14324872	2.477e-14	82.0	COG0206@1|root,arCOG02201@2157|Archaea	2157|Archaea	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	Tubulin
MMS2_k127_1238097_2	273116.14324847	8.324e-56	199.0	COG1781@1|root,arCOG04229@2157|Archaea,2XWP4@28890|Euryarchaeota,241SX@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
MMS2_k127_1238097_4	273075.Ta0575	8.676e-46	167.0	COG0540@1|root,arCOG00911@2157|Archaea,2XSZ7@28890|Euryarchaeota,241J0@183967|Thermoplasmata	183967|Thermoplasmata	F	aspartate carbamoyltransferase activity	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS2_k127_1245124_3	933801.Ahos_0106	1.792e-12	70.0	COG0842@1|root,arCOG01469@2157|Archaea,2XRBH@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_1245124_1	263820.PTO0729	2.19e-93	314.0	COG1131@1|root,arCOG00194@2157|Archaea,2Y39V@28890|Euryarchaeota,2422I@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_1245124_0	273116.14324874	1.151e-129	421.0	COG0017@1|root,arCOG00409@2157|Archaea,2XUPE@28890|Euryarchaeota,241Y0@183967|Thermoplasmata	183967|Thermoplasmata	J	tRNA synthetases class II (D, K and N)	-	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2
MMS2_k127_1245124_2	273116.14324873	5.666e-46	169.0	COG1522@1|root,arCOG01580@2157|Archaea,2XX9F@28890|Euryarchaeota,242E7@183967|Thermoplasmata	183967|Thermoplasmata	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24
MMS2_k127_127111_0	263820.PTO0542	2.705e-123	410.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,241JS@183967|Thermoplasmata	183967|Thermoplasmata	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g,tRNA_bind
MMS2_k127_127111_2	273075.Ta1160	2.116e-20	93.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,241WT@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
MMS2_k127_127111_3	1220534.B655_0855	5.937e-19	94.0	COG3371@1|root,arCOG02008@2157|Archaea,2XWKR@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_127111_1	497964.CfE428DRAFT_2469	2.239e-48	179.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS2_k127_1273147_0	273116.14325044	1.898e-174	566.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,241JB@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMS2_k127_1273147_4	263820.PTO1379	1.057e-68	245.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,241R8@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS2_k127_1273147_2	273116.14324815	6.505e-111	363.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,241N5@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
MMS2_k127_1273147_3	273116.14324814	1.106e-95	329.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,241M9@183967|Thermoplasmata	183967|Thermoplasmata	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
MMS2_k127_1273147_6	273075.Ta0570	1.908e-27	118.0	COG1936@1|root,arCOG01038@2157|Archaea,2Y662@28890|Euryarchaeota,242EY@183967|Thermoplasmata	183967|Thermoplasmata	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
MMS2_k127_1273147_5	263820.PTO1167	7.378e-48	178.0	COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,241RQ@183967|Thermoplasmata	183967|Thermoplasmata	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.39	ko:K17884	-	-	R10464	RC00002,RC00078	ko00000,ko01000	-	-	-	CDP-OH_P_transf
MMS2_k127_1273147_1	263820.PTO1166	1.079e-163	527.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,241IG@183967|Thermoplasmata	183967|Thermoplasmata	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
MMS2_k127_1273147_7	263820.PTO1165	3.398e-21	97.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7AD@28890|Euryarchaeota,24212@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_21
MMS2_k127_1290600_3	192952.MM_2222	5.403e-25	117.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUUY@28890|Euryarchaeota,2N99V@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_1290600_1	273116.14325550	3.65e-81	273.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,241PS@183967|Thermoplasmata	183967|Thermoplasmata	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
MMS2_k127_1290600_2	263820.PTO1146	1.754e-59	213.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota,242EE@183967|Thermoplasmata	183967|Thermoplasmata	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
MMS2_k127_1290600_0	985053.VMUT_0815	4.026e-259	816.0	COG0243@1|root,arCOG01492@2157|Archaea,2XQ0C@28889|Crenarchaeota	28889|Crenarchaeota	C	Molybdopterin oxidoreductase Fe4S4	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS2_k127_1327906_9	264732.Moth_2011	3.057e-07	58.0	COG5573@1|root,COG5573@2|Bacteria,1V7GS@1239|Firmicutes	1239|Firmicutes	S	PFAM PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS2_k127_1327906_8	1469948.JPNB01000001_gene533	5.426e-08	64.0	COG3837@1|root,COG3837@2|Bacteria,1V9M6@1239|Firmicutes,24HEN@186801|Clostridia,36J6K@31979|Clostridiaceae	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS2_k127_1327906_7	263820.PTO1148	8.943e-44	167.0	COG1321@1|root,arCOG02099@2157|Archaea,2Y7CA@28890|Euryarchaeota,242GR@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
MMS2_k127_1327906_2	649638.Trad_1832	1.127e-106	355.0	COG0667@1|root,COG0667@2|Bacteria,1WJPB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS2_k127_1327906_1	273075.Ta0242	5.363e-162	524.0	COG2986@1|root,arCOG04671@2157|Archaea,2XUUM@28890|Euryarchaeota,241ZU@183967|Thermoplasmata	183967|Thermoplasmata	E	histidine ammonia-lyase activity	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
MMS2_k127_1327906_0	263820.PTO0594	1.862e-238	754.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,241KD@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
MMS2_k127_1327906_4	697303.Thewi_0618	4.806e-81	282.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,42FKR@68295|Thermoanaerobacterales	186801|Clostridia	C	electron transfer flavoprotein, alpha subunit	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
MMS2_k127_1327906_3	273116.14325542	3.492e-94	317.0	COG2086@1|root,arCOG00446@2157|Archaea,2XTB8@28890|Euryarchaeota	28890|Euryarchaeota	C	Electron transfer flavoprotein, beta subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS2_k127_1327906_6	273116.14325541	6.412e-46	166.0	COG2440@1|root,arCOG01984@2157|Archaea,2XYN9@28890|Euryarchaeota,242HR@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO
MMS2_k127_1327906_5	273075.Ta0326	3.35e-64	226.0	COG0644@1|root,arCOG00570@2157|Archaea,2XV3Q@28890|Euryarchaeota,242AZ@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
MMS2_k127_1333219_1	933801.Ahos_0324	6.271e-117	387.0	COG1012@1|root,arCOG01252@2157|Archaea,2XRVS@28889|Crenarchaeota	28889|Crenarchaeota	C	Aldehyde dehydrogenase family	-	-	1.2.1.76	ko:K15038	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R09280	RC00004,RC00184	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_1333219_4	399549.Msed_1126	1.175e-43	167.0	COG1802@1|root,arCOG06044@2157|Archaea	2157|Archaea	K	PFAM regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
MMS2_k127_1333219_0	273075.Ta1393	2.435e-179	569.0	COG2721@1|root,arCOG05317@2157|Archaea,2XSWR@28890|Euryarchaeota,241XP@183967|Thermoplasmata	183967|Thermoplasmata	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
MMS2_k127_1333219_5	273075.Ta1392	1.322e-24	105.0	COG2721@1|root,arCOG05318@2157|Archaea,2Y694@28890|Euryarchaeota,242HM@183967|Thermoplasmata	183967|Thermoplasmata	G	SAF	-	-	4.2.1.7,4.4.1.24	ko:K16845,ko:K16849	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	SAF
MMS2_k127_1333219_2	273075.Ta1395	2.666e-107	362.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAS@28890|Euryarchaeota	28890|Euryarchaeota	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
MMS2_k127_1333219_3	930945.SiRe_2543	5.749e-71	248.0	COG1028@1|root,arCOG01259@2157|Archaea	2157|Archaea	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS2_k127_1380733_3	1056495.Calag_0189	7.813e-06	55.0	COG1277@1|root,arCOG02441@2157|Archaea,2XQE4@28889|Crenarchaeota	28889|Crenarchaeota	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_1380733_0	273075.Ta0840	0.0	1242.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,241IB@183967|Thermoplasmata	183967|Thermoplasmata	O	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
MMS2_k127_1380733_2	1132509.C447_04196	1.053e-10	66.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota,23WQZ@183963|Halobacteria	183963|Halobacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS2_k127_1380733_1	273116.14324803	3.377e-154	493.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,241JX@183967|Thermoplasmata	183967|Thermoplasmata	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS2_k127_138267_5	456442.Mboo_1315	3.817e-36	141.0	COG0686@1|root,arCOG06678@2157|Archaea,2XV0Z@28890|Euryarchaeota	28890|Euryarchaeota	E	Alanine dehydrogenase/PNT, C-terminal domain	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
MMS2_k127_138267_6	1123401.JHYQ01000016_gene2960	5.094e-30	122.0	COG3288@1|root,COG3288@2|Bacteria,1N0TD@1224|Proteobacteria,1SYB5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NADP transhydrogenase	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
MMS2_k127_138267_0	1123386.AUIW01000008_gene1885	4.935e-160	520.0	COG1282@1|root,COG1282@2|Bacteria,1WICZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
MMS2_k127_138267_3	243164.DET0736	1.237e-68	243.0	COG1028@1|root,COG1028@2|Bacteria,2G6RP@200795|Chloroflexi,34CMA@301297|Dehalococcoidia	301297|Dehalococcoidia	IQ	KR domain	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
MMS2_k127_138267_1	273116.14324588	2.971e-143	467.0	COG2079@1|root,arCOG04285@2157|Archaea,2XTMT@28890|Euryarchaeota,2426I@183967|Thermoplasmata	183967|Thermoplasmata	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
MMS2_k127_138267_2	273116.14324587	1.491e-99	332.0	COG2513@1|root,arCOG00581@2157|Archaea,2Y86J@28890|Euryarchaeota,241XC@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	4.1.3.30,5.4.2.9	ko:K01841,ko:K03417	ko00440,ko00640,ko01100,ko01120,ko01130,map00440,map00640,map01100,map01120,map01130	-	R00409,R00661	RC00286,RC00287,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
MMS2_k127_138267_4	521098.Aaci_2221	3.034e-53	199.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS2_k127_1390754_1	273116.14324585	2.964e-64	227.0	COG0723@1|root,arCOG01720@2157|Archaea	2157|Archaea	C	PFAM Rieske 2Fe-2S domain	soxL	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS2_k127_1390754_0	397948.Cmaq_0176	5.048e-110	378.0	COG0038@1|root,arCOG02569@2157|Archaea,2XQ0P@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CBS domain	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS2_k127_1417709_7	572478.Vdis_0243	7.947e-66	234.0	COG0622@1|root,COG2129@1|root,arCOG01141@2157|Archaea,arCOG01145@2157|Archaea,2XQCA@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM metallophosphoesterase	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos
MMS2_k127_1417709_4	572478.Vdis_1457	2.941e-93	316.0	COG1063@1|root,arCOG01459@2157|Archaea,2XQZ8@28889|Crenarchaeota	28889|Crenarchaeota	C	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS2_k127_1417709_5	273075.Ta1286m	1.192e-87	294.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,241PP@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
MMS2_k127_1417709_2	263820.PTO0162	1.238e-165	536.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_1417709_14	243231.GSU2362	2.877e-08	61.0	COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,43AC3@68525|delta/epsilon subdivisions,2X5RZ@28221|Deltaproteobacteria,43UX1@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
MMS2_k127_1417709_10	443143.GM18_2743	1.243e-40	165.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
MMS2_k127_1417709_6	386456.JQKN01000001_gene2139	1.281e-66	239.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT1I@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS2_k127_1417709_9	263820.PTO1157	4.056e-43	167.0	arCOG01995@1|root,arCOG01995@2157|Archaea,2Y5MJ@28890|Euryarchaeota,242H6@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1417709_1	273116.14325041	2.506e-227	715.0	COG0146@1|root,arCOG01512@2157|Archaea,2Y8DU@28890|Euryarchaeota,24253@183967|Thermoplasmata	183967|Thermoplasmata	E	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
MMS2_k127_1417709_0	273116.14325042	1.637e-233	739.0	COG0145@1|root,arCOG01511@2157|Archaea,2XT1J@28890|Euryarchaeota,2421A@183967|Thermoplasmata	183967|Thermoplasmata	E	Hydantoinase/oxoprolinase N-terminal region	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
MMS2_k127_1417709_12	1283283.ATXA01000002_gene2639	1.362e-15	82.0	COG3427@1|root,COG3427@2|Bacteria,2IEYK@201174|Actinobacteria,4ET36@85013|Frankiales	201174|Actinobacteria	S	carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
MMS2_k127_1417709_8	1242864.D187_001408	6.742e-48	182.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
MMS2_k127_1417709_11	1460635.JCM19038_2389	1.451e-34	148.0	COG2271@1|root,COG2271@2|Bacteria,1V0VC@1239|Firmicutes,4HCQG@91061|Bacilli	91061|Bacilli	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_1417709_3	263820.PTO1067	2.17e-109	357.0	COG1378@1|root,arCOG02037@2157|Archaea,2XX7F@28890|Euryarchaeota,24255@183967|Thermoplasmata	183967|Thermoplasmata	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
MMS2_k127_1417709_13	273075.Ta0891	1.291e-14	75.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota,2429E@183967|Thermoplasmata	183967|Thermoplasmata	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS2_k127_1467819_9	263820.PTO0860	4.563e-18	88.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2420K@183967|Thermoplasmata	183967|Thermoplasmata	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS2_k127_1467819_5	273116.14325027	5.822e-74	262.0	COG0517@1|root,arCOG00601@2157|Archaea,2XT75@28890|Euryarchaeota,241TW@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_1467819_3	273075.Ta0811	1.338e-101	343.0	COG0112@1|root,arCOG00070@2157|Archaea,2XX80@28890|Euryarchaeota,2420Y@183967|Thermoplasmata	183967|Thermoplasmata	H	Serine hydroxymethyltransferase	-	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
MMS2_k127_1467819_7	273116.14324939	2.676e-49	191.0	COG0477@1|root,arCOG00135@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_1467819_8	273116.14325493	1.078e-22	102.0	arCOG05400@1|root,arCOG05400@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
MMS2_k127_1467819_4	263820.PTO0096	3.758e-80	274.0	COG0842@1|root,arCOG01467@2157|Archaea,2XT3B@28890|Euryarchaeota,2429G@183967|Thermoplasmata	183967|Thermoplasmata	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_1467819_2	263820.PTO0095	5.79e-104	346.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT0T@28890|Euryarchaeota,24233@183967|Thermoplasmata	183967|Thermoplasmata	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_1467819_11	1382358.JHVN01000004_gene2595	1.366e-06	59.0	COG1664@1|root,COG1664@2|Bacteria,1V6E6@1239|Firmicutes	1239|Firmicutes	M	COG1664 Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
MMS2_k127_1467819_12	1144312.PMI09_05737	0.0005136	48.0	COG1733@1|root,COG1733@2|Bacteria,1RGWE@1224|Proteobacteria,2VF6R@28211|Alphaproteobacteria,4BEIF@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	ytfH	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS2_k127_1467819_0	273116.14325054	4.445e-309	964.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,241KW@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA polymerase type-B family	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
MMS2_k127_1467819_10	263820.PTO0285	6.211e-15	79.0	arCOG03681@1|root,arCOG03681@2157|Archaea,2Y5YK@28890|Euryarchaeota,242HF@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1467819_6	273075.Ta0858	6.439e-54	200.0	COG1052@1|root,arCOG01755@2157|Archaea,2XZQ9@28890|Euryarchaeota,24272@183967|Thermoplasmata	183967|Thermoplasmata	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_1467819_1	263820.PTO0568	2.01e-107	354.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,241PD@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
MMS2_k127_1496628_6	273116.14325360	1.165e-58	213.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMS2_k127_1496628_3	273116.14325362	3.174e-127	414.0	COG0113@1|root,arCOG04300@2157|Archaea,2XSZ8@28890|Euryarchaeota,241IJ@183967|Thermoplasmata	183967|Thermoplasmata	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
MMS2_k127_1496628_4	273116.14325361	7.973e-106	345.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota,2420M@183967|Thermoplasmata	183967|Thermoplasmata	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
MMS2_k127_1496628_8	273075.Ta0956	8.358e-26	110.0	arCOG05406@1|root,arCOG05406@2157|Archaea,2Y4Q6@28890|Euryarchaeota,242E0@183967|Thermoplasmata	183967|Thermoplasmata	S	Thermoplasma acidophilum protein TA0956	-	-	-	-	-	-	-	-	-	-	-	-	TA0956
MMS2_k127_1496628_10	273075.Ta1223a	1.928e-20	94.0	COG1826@1|root,arCOG02694@2157|Archaea,2Y23W@28890|Euryarchaeota,242BR@183967|Thermoplasmata	183967|Thermoplasmata	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
MMS2_k127_1496628_5	263820.PTO1131	1.638e-76	265.0	COG0805@1|root,arCOG01919@2157|Archaea,2Y7D8@28890|Euryarchaeota,2423Y@183967|Thermoplasmata	183967|Thermoplasmata	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
MMS2_k127_1496628_7	273075.Ta0957	2.258e-26	110.0	arCOG05405@1|root,arCOG05405@2157|Archaea,2Y539@28890|Euryarchaeota,242FK@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1496628_12	273116.14325365	2.736e-13	74.0	arCOG05378@1|root,arCOG05378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1496628_2	273075.Ta0959	1.319e-148	486.0	COG1007@1|root,arCOG01540@2157|Archaea,2XSY7@28890|Euryarchaeota,241P2@183967|Thermoplasmata	183967|Thermoplasmata	C	Proton-conducting membrane transporter	-	-	1.5.98.3,1.6.5.3	ko:K00343,ko:K22169	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M
MMS2_k127_1496628_1	273075.Ta0960	1.983e-149	487.0	COG1008@1|root,arCOG01538@2157|Archaea,2XTP0@28890|Euryarchaeota,241NU@183967|Thermoplasmata	183967|Thermoplasmata	C	Proton-conducting membrane transporter	-	-	1.5.98.3,1.6.5.3	ko:K00342,ko:K22168	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M
MMS2_k127_1496628_0	273075.Ta0961	3.844e-212	676.0	COG1009@1|root,arCOG01539@2157|Archaea,2XT4R@28890|Euryarchaeota,241J9@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.5.98.3,1.6.5.3	ko:K00341,ko:K22167	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Proton_antipo_M,Proton_antipo_N
MMS2_k127_1496628_9	273116.14325370	3.438e-22	100.0	COG0713@1|root,arCOG03073@2157|Archaea,2Y70N@28890|Euryarchaeota,242BP@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
MMS2_k127_1496628_11	273075.Ta0964	4.762e-18	87.0	COG0839@1|root,arCOG04654@2157|Archaea,2Y7C8@28890|Euryarchaeota,242GG@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
MMS2_k127_1496628_13	263820.PTO1405	9.377e-13	68.0	COG1143@1|root,arCOG01543@2157|Archaea,2Y79M@28890|Euryarchaeota,241VP@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
MMS2_k127_1508804_0	263820.PTO0189	2.271e-69	248.0	COG1537@1|root,arCOG01741@2157|Archaea,2XTQ4@28890|Euryarchaeota,241SZ@183967|Thermoplasmata	183967|Thermoplasmata	J	May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity	pelA	-	-	ko:K06965	ko03015,map03015	-	-	-	ko00000,ko00001	-	-	-	eRF1_1,eRF1_3
MMS2_k127_1508804_2	263820.PTO0190	1.247e-27	117.0	COG1656@1|root,arCOG04290@2157|Archaea,2XXTT@28890|Euryarchaeota,242H9@183967|Thermoplasmata	183967|Thermoplasmata	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
MMS2_k127_1508804_1	273116.14324675	8.826e-48	173.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,241QB@183967|Thermoplasmata	183967|Thermoplasmata	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMS2_k127_1536917_2	1501230.ET33_14895	1.183e-115	381.0	COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,4H9WX@91061|Bacilli,26RW8@186822|Paenibacillaceae	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS2_k127_1536917_0	1501230.ET33_14890	1.061e-259	820.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,4H9X0@91061|Bacilli,26U46@186822|Paenibacillaceae	91061|Bacilli	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
MMS2_k127_1536917_5	699246.HMPREF0868_0099	9.282e-38	154.0	COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,249AN@186801|Clostridia	186801|Clostridia	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
MMS2_k127_1536917_1	273075.Ta1476	8.346e-122	397.0	COG3404@1|root,arCOG05394@2157|Archaea,2XX41@28890|Euryarchaeota,2420F@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the formyl group from N- formylglutamate to tetrahydrofolate (THF) to yield 5- formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5-formiminotetrahydrofolate (5-NH CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrofolate (5,10-CH THF)	-	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
MMS2_k127_1536917_6	2325.TKV_c19910	2.881e-29	124.0	COG3404@1|root,COG3404@2|Bacteria,1V14R@1239|Firmicutes,24D90@186801|Clostridia,42G31@68295|Thermoanaerobacterales	186801|Clostridia	E	Formiminotransferase-cyclodeaminase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
MMS2_k127_1536917_7	273075.Ta1144a	8.595e-18	85.0	COG5466@1|root,arCOG05278@2157|Archaea,2Y5U3@28890|Euryarchaeota,242H8@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMS2_k127_1536917_3	273075.Ta0156	2.868e-49	180.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EG@28890|Euryarchaeota,2424M@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_156474_0	273116.14324233	1.686e-216	690.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,241KQ@183967|Thermoplasmata	183967|Thermoplasmata	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS2_k127_156474_4	263820.PTO0235	3.549e-36	144.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,241U1@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
MMS2_k127_156474_1	263820.PTO0236	2.716e-131	428.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,241J7@183967|Thermoplasmata	183967|Thermoplasmata	S	C-terminal region of MMR_HSR1 domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
MMS2_k127_156474_3	933801.Ahos_2246	1.189e-36	150.0	COG0668@1|root,arCOG01573@2157|Archaea	2157|Archaea	M	PFAM Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
MMS2_k127_156474_2	273116.14324228	5.851e-42	159.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,241VK@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS2_k127_156474_5	387631.Asulf_00955	3.863e-17	91.0	arCOG07100@1|root,arCOG07100@2157|Archaea,2XZZK@28890|Euryarchaeota,2470E@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF3800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3800
MMS2_k127_157325_4	189426.PODO_19780	1.896e-49	184.0	COG3214@1|root,COG3214@2|Bacteria,1UYQ5@1239|Firmicutes,4I21F@91061|Bacilli,275DR@186822|Paenibacillaceae	91061|Bacilli	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS2_k127_157325_2	411902.CLOBOL_05803	2.707e-68	241.0	COG2189@1|root,COG2189@2|Bacteria,1UHUQ@1239|Firmicutes,25E35@186801|Clostridia,2226V@1506553|Lachnoclostridium	186801|Clostridia	L	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS2_k127_157325_0	273075.Ta1024	3.355e-206	657.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XVRP@28890|Euryarchaeota,2420N@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_157325_1	1382306.JNIM01000001_gene2077	3.491e-72	264.0	COG0531@1|root,COG0531@2|Bacteria,2G76Z@200795|Chloroflexi	200795|Chloroflexi	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
MMS2_k127_157325_5	411490.ANACAC_03351	8.501e-30	131.0	COG0371@1|root,COG0371@2|Bacteria,1V994@1239|Firmicutes	1239|Firmicutes	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH_2
MMS2_k127_157325_3	273075.Ta0672	1.281e-60	218.0	COG1028@1|root,arCOG01259@2157|Archaea,2XVZM@28890|Euryarchaeota	28890|Euryarchaeota	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS2_k127_157325_6	1347087.CBYO010000007_gene1294	9.357e-18	86.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,4HKEF@91061|Bacilli	91061|Bacilli	J	endoribonuclease L-PSP	yabJ	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
MMS2_k127_1628203_2	273116.14324821	7.24e-17	81.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2428B@183967|Thermoplasmata	183967|Thermoplasmata	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
MMS2_k127_1628203_3	263820.PTO0781	3.877e-15	79.0	COG3609@1|root,arCOG06966@2157|Archaea,2Y5GZ@28890|Euryarchaeota	28890|Euryarchaeota	K	Ribbon-helix-helix protein, copG family	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	RHH_1
MMS2_k127_1628203_4	671065.MetMK1DRAFT_00005900	5.332e-05	54.0	arCOG03768@1|root,arCOG03768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF973
MMS2_k127_1628203_0	263820.PTO0523	5.521e-87	297.0	COG0673@1|root,arCOG01622@2157|Archaea,2Y7AH@28890|Euryarchaeota,2423R@183967|Thermoplasmata	183967|Thermoplasmata	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS2_k127_1628203_1	273116.14324820	1.102e-22	102.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,241N1@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
MMS2_k127_1640576_1	273075.Ta1162	4.436e-95	316.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,241JS@183967|Thermoplasmata	183967|Thermoplasmata	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g,tRNA_bind
MMS2_k127_1640576_2	273075.Ta1377	1.026e-89	308.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_1640576_5	1006006.Mcup_0554	1.971e-65	237.0	COG0075@1|root,arCOG00082@2157|Archaea,2XQJ2@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
MMS2_k127_1640576_3	273063.STK_12180	1.417e-79	276.0	COG0111@1|root,arCOG01754@2157|Archaea,2XPRE@28889|Crenarchaeota	28889|Crenarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_1640576_0	273116.14324271	2.073e-120	396.0	COG0404@1|root,arCOG00756@2157|Archaea,2XU1F@28890|Euryarchaeota,241ZF@183967|Thermoplasmata	183967|Thermoplasmata	H	Aminomethyltransferase folate-binding domain	-	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
MMS2_k127_1640576_4	273075.Ta0009	4.923e-66	231.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,241RU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
MMS2_k127_1640576_6	118168.MC7420_1988	1.162e-11	75.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
MMS2_k127_1640576_7	439481.Aboo_0779	2.214e-07	64.0	COG4870@1|root,arCOG02501@1|root,arCOG03439@1|root,arCOG02501@2157|Archaea,arCOG03439@2157|Archaea,arCOG03607@2157|Archaea	2157|Archaea	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_3,Big_3_5,NosD,PKD,Peptidase_C1,S_layer_C
MMS2_k127_1661844_6	985053.VMUT_0815	9.023e-54	195.0	COG0243@1|root,arCOG01492@2157|Archaea,2XQ0C@28889|Crenarchaeota	28889|Crenarchaeota	C	Molybdopterin oxidoreductase Fe4S4	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS2_k127_1661844_1	768679.TTX_1270	1.728e-123	413.0	COG1894@1|root,COG1905@1|root,arCOG04537@2157|Archaea,arCOG04890@2157|Archaea,2XRQD@28889|Crenarchaeota	28889|Crenarchaeota	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.17.1.9,1.6.5.3	ko:K00122,ko:K00335	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S
MMS2_k127_1661844_7	273075.Ta0471	2.383e-52	191.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y89K@28890|Euryarchaeota,242IE@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
MMS2_k127_1661844_10	273075.Ta0472	6.093e-29	123.0	COG1777@1|root,arCOG01684@2157|Archaea,2Y680@28890|Euryarchaeota,241VW@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
MMS2_k127_1661844_9	42256.RradSPS_0012	1.731e-37	151.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1661844_3	1303518.CCALI_00475	3.391e-92	309.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
MMS2_k127_1661844_0	1051632.TPY_3362	4.594e-203	647.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,3WD2K@538999|Clostridiales incertae sedis	186801|Clostridia	C	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative mitochondrial subgroup	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
MMS2_k127_1661844_8	673860.AciM339_0455	2.036e-38	153.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,3F2J0@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	GO:0003674,GO:0003824,GO:0004164,GO:0006417,GO:0006448,GO:0006464,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009056,GO:0009058,GO:0009109,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0010608,GO:0016740,GO:0016741,GO:0017144,GO:0017182,GO:0017183,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0032259,GO:0032268,GO:0034248,GO:0036211,GO:0042737,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044273,GO:0046500,GO:0050789,GO:0050794,GO:0050843,GO:0051171,GO:0051186,GO:0051187,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1900247,GO:1901564,GO:1901575,GO:2000112,GO:2000765	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
MMS2_k127_1661844_2	673860.AciM339_1255	8.562e-117	388.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,3F2J7@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
MMS2_k127_1661844_4	273116.14325248	3.01e-68	236.0	COG0663@1|root,arCOG01849@2157|Archaea,2XWNM@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
MMS2_k127_1661844_5	273075.Ta0880	1.412e-62	225.0	COG0524@1|root,arCOG00014@2157|Archaea,2Y65P@28890|Euryarchaeota,241U0@183967|Thermoplasmata	183967|Thermoplasmata	F	pfkB family carbohydrate kinase	-	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006213,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008617,GO:0008906,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009129,GO:0009130,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042278,GO:0042455,GO:0043167,GO:0043168,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046033,GO:0046035,GO:0046085,GO:0046087,GO:0046102,GO:0046128,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1905108	2.7.1.213,2.7.1.73	ko:K22026	ko00230,ko00240,map00230,map00240	-	R00513,R01131,R01228	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
MMS2_k127_1700662_1	263820.PTO0336	7.104e-137	451.0	COG0469@1|root,arCOG04120@2157|Archaea,2XU34@28890|Euryarchaeota,24224@183967|Thermoplasmata	183967|Thermoplasmata	F	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
MMS2_k127_1700662_2	263820.PTO0339	3.565e-93	315.0	COG2876@1|root,arCOG01049@2157|Archaea,2XWR8@28890|Euryarchaeota,2426P@183967|Thermoplasmata	183967|Thermoplasmata	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
MMS2_k127_1700662_7	263820.PTO0340	4.737e-46	175.0	COG0134@1|root,arCOG01088@2157|Archaea,2XTWK@28890|Euryarchaeota,241XE@183967|Thermoplasmata	183967|Thermoplasmata	E	indole-3-glycerol-phosphate synthase activity	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
MMS2_k127_1700662_6	263820.PTO0341	3.344e-51	187.0	COG0512@1|root,arCOG00086@2157|Archaea,2XTES@28890|Euryarchaeota,241TH@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamine amidotransferase class-I	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
MMS2_k127_1700662_3	263820.PTO0342	6.837e-79	278.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,241T2@183967|Thermoplasmata	183967|Thermoplasmata	E	chorismate binding enzyme	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
MMS2_k127_1700662_8	273116.14325292	2.799e-27	119.0	COG0135@1|root,arCOG01983@2157|Archaea,2Y7BT@28890|Euryarchaeota,242BQ@183967|Thermoplasmata	183967|Thermoplasmata	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
MMS2_k127_1700662_4	263820.PTO0344	2.849e-57	212.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,241QR@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
MMS2_k127_1700662_5	263820.PTO0345	9.01e-52	192.0	COG0159@1|root,arCOG01086@2157|Archaea,2Y7BP@28890|Euryarchaeota,242D7@183967|Thermoplasmata	183967|Thermoplasmata	E	Tryptophan synthase alpha chain	-	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
MMS2_k127_1700662_0	263820.PTO0346	3.17e-176	561.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,241KU@183967|Thermoplasmata	183967|Thermoplasmata	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_1700662_9	273075.Ta0801	1.917e-07	56.0	COG2226@1|root,arCOG04348@2157|Archaea,2Y6PI@28890|Euryarchaeota,242CN@183967|Thermoplasmata	183967|Thermoplasmata	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
MMS2_k127_171339_2	273075.Ta1128m	1.202e-23	102.0	COG3375@1|root,arCOG04215@2157|Archaea,2Y3C8@28890|Euryarchaeota,2426D@183967|Thermoplasmata	183967|Thermoplasmata	M	carboxylic acid catabolic process	-	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_171339_1	1396141.BATP01000061_gene4515	1.003e-54	195.0	COG1917@1|root,COG1917@2|Bacteria,46V66@74201|Verrucomicrobia,2IUU3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Cupin domain	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD,Cupin_2
MMS2_k127_171339_5	351160.LRC302	2.093e-05	53.0	arCOG11123@1|root,arCOG11123@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_171339_0	368408.Tpen_1273	5.506e-66	236.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_171339_4	666510.ASAC_0726	4.141e-06	57.0	COG1277@1|root,arCOG02441@2157|Archaea	2157|Archaea	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_171339_3	1382306.JNIM01000001_gene739	7.696e-16	82.0	COG1725@1|root,COG1725@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
MMS2_k127_171339_6	1463854.JOHT01000009_gene1907	0.000124	51.0	COG4194@1|root,COG4194@2|Bacteria,2IBNS@201174|Actinobacteria	201174|Actinobacteria	K	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1648
MMS2_k127_174489_4	263820.PTO0134	4.659e-26	115.0	arCOG06267@1|root,arCOG06267@2157|Archaea	2157|Archaea	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_174489_3	263820.PTO0133	1.51e-55	201.0	arCOG06267@1|root,arCOG06267@2157|Archaea	2157|Archaea	V	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_174489_0	263820.PTO0411	0.0	1135.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,241IC@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_174489_1	439481.Aboo_0486	1.548e-119	392.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,3F2I1@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaAB	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
MMS2_k127_174489_2	263820.PTO0517	2.636e-71	243.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS2_k127_1754632_2	933801.Ahos_0333	2.363e-54	199.0	COG1501@1|root,arCOG03663@2157|Archaea,2XRWK@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 31 family	malA	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
MMS2_k127_1754632_0	525904.Tter_1501	1.751e-81	305.0	COG0383@1|root,COG0383@2|Bacteria,2NNPD@2323|unclassified Bacteria	2|Bacteria	G	Glycoside hydrolase family 38 central region	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
MMS2_k127_1754632_1	273116.14324423	2.535e-59	220.0	COG0383@1|root,arCOG03661@2157|Archaea,2XVNX@28890|Euryarchaeota,241Z5@183967|Thermoplasmata	183967|Thermoplasmata	G	Alpha mannosidase, middle domain	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38
MMS2_k127_1757732_2	671065.MetMK1DRAFT_00026550	4.314e-31	128.0	COG0454@1|root,arCOG00831@2157|Archaea,2XSA6@28889|Crenarchaeota	28889|Crenarchaeota	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1757732_1	273075.Ta0249	9.79e-137	443.0	COG4948@1|root,arCOG01168@2157|Archaea,2XUAK@28890|Euryarchaeota,2420X@183967|Thermoplasmata	183967|Thermoplasmata	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS2_k127_1757732_0	330779.Saci_1137	4.55e-165	537.0	COG0028@1|root,arCOG01998@2157|Archaea,2XPT4@28889|Crenarchaeota	28889|Crenarchaeota	E	TPP binding domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS2_k127_1798280_2	263820.PTO1217	5.996e-76	263.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,241KG@183967|Thermoplasmata	183967|Thermoplasmata	L	MCM OB domain	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_OB
MMS2_k127_1798280_1	273116.14325421	2.313e-130	428.0	COG3635@1|root,arCOG01696@2157|Archaea,2XTE8@28890|Euryarchaeota,241WY@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
MMS2_k127_1798280_4	273116.14325422	1.539e-29	126.0	arCOG03853@1|root,arCOG03853@2157|Archaea,2Y52X@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1798280_0	273075.Ta0468	5.947e-165	529.0	COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,241N0@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
MMS2_k127_1798280_3	572546.Arcpr_1222	7.546e-40	161.0	COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota	28890|Euryarchaeota	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
MMS2_k127_1798280_5	273075.Ta0414	4.317e-16	79.0	COG0493@1|root,arCOG01292@2157|Archaea,2XVPT@28890|Euryarchaeota	28890|Euryarchaeota	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14,1.8.1.19	ko:K00266,ko:K20202	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
MMS2_k127_1874058_2	273116.14324841	7.711e-16	79.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,241U7@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterised protein family (UPF0147)	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
MMS2_k127_1874058_1	263820.PTO0200	4.136e-22	98.0	COG1522@1|root,arCOG01580@2157|Archaea	2157|Archaea	K	COG1522 Transcriptional regulators	asnC1	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
MMS2_k127_1874058_0	263820.PTO1428	2.397e-206	679.0	COG2409@1|root,arCOG02175@2157|Archaea,2XVKJ@28890|Euryarchaeota,241Q8@183967|Thermoplasmata	183967|Thermoplasmata	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
MMS2_k127_1879684_5	263820.PTO0250	9.131e-27	119.0	COG1587@1|root,arCOG02048@2157|Archaea,2Y7BD@28890|Euryarchaeota,242B6@183967|Thermoplasmata	183967|Thermoplasmata	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
MMS2_k127_1879684_1	263820.PTO0249	2.477e-69	245.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,241PT@183967|Thermoplasmata	183967|Thermoplasmata	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
MMS2_k127_1879684_0	273075.Ta0571	1.581e-130	428.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,241IX@183967|Thermoplasmata	183967|Thermoplasmata	H	intramolecular transferase activity, transferring amino groups	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_1879684_3	263820.PTO0680	1.398e-58	215.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,241TB@183967|Thermoplasmata	183967|Thermoplasmata	J	Met-10+ like-protein	-	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
MMS2_k127_1879684_4	1291050.JAGE01000001_gene1782	3.944e-54	195.0	COG1335@1|root,COG1335@2|Bacteria,1V7MY@1239|Firmicutes,24HVW@186801|Clostridia	186801|Clostridia	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS2_k127_1879684_2	670487.Ocepr_1815	1.667e-59	213.0	COG3288@1|root,COG3288@2|Bacteria,1WIIT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	NAD NADP transhydrogenase alpha subunit	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
MMS2_k127_1947773_1	204669.Acid345_0966	8.717e-70	244.0	COG0384@1|root,COG0384@2|Bacteria,3Y4H0@57723|Acidobacteria,2JJ47@204432|Acidobacteriia	204432|Acidobacteriia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
MMS2_k127_1947773_3	399549.Msed_0753	1.149e-40	156.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_1947773_5	323259.Mhun_0982	1.483e-10	63.0	COG2217@1|root,arCOG02763@1|root,arCOG04508@1|root,arCOG01576@2157|Archaea,arCOG02763@2157|Archaea,arCOG04508@2157|Archaea,2XT3T@28890|Euryarchaeota,2N94W@224756|Methanomicrobia	224756|Methanomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
MMS2_k127_1947773_2	397948.Cmaq_0734	2.482e-46	175.0	COG3371@1|root,arCOG02008@2157|Archaea,2XQNY@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_1947773_4	263820.PTO1076	8.982e-38	152.0	COG0338@1|root,arCOG03416@2157|Archaea,2XWJX@28890|Euryarchaeota	28890|Euryarchaeota	L	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
MMS2_k127_1947773_0	273116.14325530	4.659e-137	449.0	COG0365@1|root,arCOG01529@2157|Archaea,2XTEH@28890|Euryarchaeota	28890|Euryarchaeota	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acs1	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS2_k127_1949259_12	945713.IALB_1465	9.294e-114	378.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_1949259_5	273116.14325561	1.102e-223	718.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,24243@183967|Thermoplasmata	183967|Thermoplasmata	E	Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids	trf2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS2_k127_1949259_7	273075.Ta0296	1.269e-181	575.0	COG0183@1|root,arCOG01282@2157|Archaea,2XT8C@28890|Euryarchaeota,2423Q@183967|Thermoplasmata	183967|Thermoplasmata	I	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_1949259_10	273116.14325567	7.094e-141	456.0	COG1960@1|root,arCOG01708@2157|Archaea,2Y7GC@28890|Euryarchaeota,24217@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_1949259_17	273075.Ta0294	6.925e-44	173.0	COG1960@1|root,arCOG01707@2157|Archaea,2Y3XS@28890|Euryarchaeota,242BF@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
MMS2_k127_1949259_14	273075.Ta0378	4.872e-89	300.0	COG0681@1|root,arCOG01739@2157|Archaea,2Y79C@28890|Euryarchaeota,241T8@183967|Thermoplasmata	183967|Thermoplasmata	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS2_k127_1949259_21	933801.Ahos_0079	3.556e-14	76.0	arCOG03851@1|root,arCOG03851@2157|Archaea,2XR8Z@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1949259_11	933801.Ahos_1027	3.342e-124	429.0	COG3280@1|root,arCOG02955@2157|Archaea	2157|Archaea	G	Alpha amylase, catalytic domain	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
MMS2_k127_1949259_9	909663.KI867151_gene3003	2.18e-146	485.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WIQJ@28221|Deltaproteobacteria,2MR2P@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	alpha amylase, catalytic	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
MMS2_k127_1949259_3	479434.Sthe_2691	1.08e-262	826.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
MMS2_k127_1949259_4	273075.Ta0444	4.795e-239	742.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,241IH@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
MMS2_k127_1949259_16	263820.PTO0416	7.899e-54	192.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,241R0@183967|Thermoplasmata	183967|Thermoplasmata	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
MMS2_k127_1949259_0	263820.PTO0417	0.0	1191.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,241J6@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
MMS2_k127_1949259_2	263820.PTO1415	1.861e-277	874.0	COG0188@1|root,arCOG04367@2157|Archaea,2XTZV@28890|Euryarchaeota,241JQ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA Topoisomerase IV	-	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
MMS2_k127_1949259_1	273116.14324756	3.045e-289	900.0	COG0187@1|root,arCOG04371@2157|Archaea,2XSVX@28890|Euryarchaeota,241Z0@183967|Thermoplasmata	183967|Thermoplasmata	L	TopoisomeraseII	-	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
MMS2_k127_1949259_19	273075.Ta1056	1.696e-25	107.0	arCOG04007@1|root,arCOG04007@2157|Archaea,2Y580@28890|Euryarchaeota,242FA@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1949259_22	273116.14324982	2.1e-10	64.0	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
MMS2_k127_1949259_13	273075.Ta0941	4.797e-104	347.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,241NE@183967|Thermoplasmata	183967|Thermoplasmata	S	Nucleolar GTP-binding protein 1 (NOG1)	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	MMR_HSR1,NOG1
MMS2_k127_1949259_6	263820.PTO0878	2.445e-204	649.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,241JP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
MMS2_k127_1949259_20	273075.Ta0943	4.892e-16	80.0	COG1873@1|root,arCOG02155@2157|Archaea	2157|Archaea	S	PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
MMS2_k127_1949259_15	273116.14325350	4.93e-76	259.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,241QC@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
MMS2_k127_1949259_8	273075.Ta0945	1.061e-172	545.0	COG1405@1|root,arCOG01981@2157|Archaea,2XU76@28890|Euryarchaeota,2422B@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbB	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS2_k127_1949259_18	273075.Ta0668	2.273e-39	151.0	COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,241WV@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_1995243_1	273075.Ta0490	8.96e-113	370.0	arCOG07379@1|root,arCOG07379@2157|Archaea	2157|Archaea	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1995243_7	273075.Ta0489	2.445e-51	190.0	arCOG07378@1|root,arCOG07378@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1995243_4	273075.Ta0488	4.545e-71	260.0	COG0515@1|root,arCOG07377@2157|Archaea	2157|Archaea	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_1995243_2	985053.VMUT_1160	9.463e-99	331.0	COG2421@1|root,arCOG01004@2157|Archaea,2XQIP@28889|Crenarchaeota	28889|Crenarchaeota	C	Acetamidase/Formamidase family	-	-	3.5.1.4,3.5.1.49	ko:K01426,ko:K01455	ko00330,ko00360,ko00380,ko00460,ko00627,ko00630,ko00643,ko00910,ko01120,ko01200,map00330,map00360,map00380,map00460,map00627,map00630,map00643,map00910,map01120,map01200	-	R00524,R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025,RC02432,RC02810	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
MMS2_k127_1995243_0	273075.Ta1380	3.23e-136	445.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,2423F@183967|Thermoplasmata	183967|Thermoplasmata	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
MMS2_k127_1995243_5	273075.Ta1381	1.183e-66	238.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,241RK@183967|Thermoplasmata	183967|Thermoplasmata	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS2_k127_1995243_3	263820.PTO1316	2.065e-88	298.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,241SN@183967|Thermoplasmata	183967|Thermoplasmata	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
MMS2_k127_1995243_6	1123248.KB893321_gene519	8.643e-57	200.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,1ISZN@117747|Sphingobacteriia	976|Bacteroidetes	O	Peptide-methionine (R)-S-oxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
MMS2_k127_1995243_8	1097668.BYI23_A021540	0.0003059	46.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2VR6F@28216|Betaproteobacteria,1K3ZU@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
MMS2_k127_2002512_0	273075.Ta0429	8.579e-147	484.0	COG2025@1|root,arCOG00448@2157|Archaea,2Y2B4@28890|Euryarchaeota,2424H@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS2_k127_2002512_2	273075.Ta0428	7.618e-30	122.0	COG2146@1|root,arCOG02852@2157|Archaea,2Y7BW@28890|Euryarchaeota,242EM@183967|Thermoplasmata	183967|Thermoplasmata	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS2_k127_2002512_1	263820.PTO1091	1.143e-81	276.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,241PI@183967|Thermoplasmata	183967|Thermoplasmata	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS2_k127_2041327_3	273075.Ta0216	8.74e-41	156.0	COG1032@1|root,arCOG01364@2157|Archaea,2XVND@28890|Euryarchaeota,2423G@183967|Thermoplasmata	183967|Thermoplasmata	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
MMS2_k127_2041327_1	397948.Cmaq_0421	1.79e-164	536.0	COG4670@1|root,arCOG01986@2157|Archaea,2XQ55@28889|Crenarchaeota	28889|Crenarchaeota	I	PFAM Coenzyme A transferase	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
MMS2_k127_2041327_2	930945.SiRe_2316	1.078e-43	161.0	COG2146@1|root,arCOG02854@2157|Archaea,2XS41@28889|Crenarchaeota	28889|Crenarchaeota	C	2 iron, 2 sulfur cluster binding	sdx	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Rieske
MMS2_k127_2041327_0	263820.PTO1346	1.397e-205	651.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,241K5@183967|Thermoplasmata	183967|Thermoplasmata	K	Radical_SAM C-terminal domain	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
MMS2_k127_2041327_4	263820.PTO0153	1.376e-15	81.0	arCOG05325@1|root,arCOG05325@2157|Archaea,2Y5Z7@28890|Euryarchaeota,242GD@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_206753_0	263820.PTO1241	8.111e-267	833.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,241MT@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
MMS2_k127_206753_2	56107.Cylst_5546	1.129e-56	203.0	COG0783@1|root,COG0783@2|Bacteria,1G54E@1117|Cyanobacteria,1HMZ3@1161|Nostocales	1117|Cyanobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
MMS2_k127_206753_1	269797.Mbar_A1642	1.534e-126	424.0	COG1796@1|root,arCOG00305@2157|Archaea,2XT14@28890|Euryarchaeota,2N90T@224756|Methanomicrobia	224756|Methanomicrobia	L	Helix-hairpin-helix domain	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
MMS2_k127_206753_5	448385.sce4978	6.634e-29	124.0	COG0300@1|root,COG0300@2|Bacteria,1QUNR@1224|Proteobacteria,43CVE@68525|delta/epsilon subdivisions,2X83C@28221|Deltaproteobacteria,2Z3K2@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
MMS2_k127_206753_3	446470.Snas_3751	2.452e-47	183.0	COG0809@1|root,COG0809@2|Bacteria,2GN51@201174|Actinobacteria,4EZJG@85014|Glycomycetales	201174|Actinobacteria	J	Queuosine biosynthesis protein	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
MMS2_k127_206753_6	263820.PTO0774	7.771e-19	102.0	arCOG06052@1|root,arCOG06052@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB
MMS2_k127_206753_4	673860.AciM339_1044	6.321e-36	158.0	COG1572@1|root,COG4934@1|root,arCOG02532@2157|Archaea,arCOG03669@2157|Archaea,2Y7X2@28890|Euryarchaeota,3F35Y@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CarboxypepD_reg,Pro-kuma_activ
MMS2_k127_2071963_0	263820.PTO1054	2.531e-173	565.0	COG3590@1|root,arCOG05200@2157|Archaea,2XVU0@28890|Euryarchaeota	28890|Euryarchaeota	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
MMS2_k127_2071963_7	439481.Aboo_1283	2.158e-35	142.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,3F36M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
MMS2_k127_2071963_6	263820.PTO0526	9.116e-39	147.0	arCOG02738@1|root,arCOG02738@2157|Archaea,2Y4Q5@28890|Euryarchaeota,242E8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2071963_1	273116.14324379	1.063e-145	468.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,241K3@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoribosylformylglycinamidine cyclo-ligase activity	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_2071963_8	273063.STK_24010	4.329e-21	98.0	COG1032@1|root,arCOG01357@2157|Archaea,2XRPA@28889|Crenarchaeota	28889|Crenarchaeota	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS2_k127_2071963_5	263820.PTO0528	7.54e-72	244.0	COG1146@1|root,arCOG04548@2157|Archaea,2XXXG@28890|Euryarchaeota,2426K@183967|Thermoplasmata	183967|Thermoplasmata	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_2071963_9	273116.14325603	1.206e-11	74.0	arCOG07367@1|root,arCOG07367@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	-
MMS2_k127_2071963_4	273075.Ta0238	7.717e-93	319.0	COG1228@1|root,arCOG00696@2157|Archaea,2XUHH@28890|Euryarchaeota,241YC@183967|Thermoplasmata	183967|Thermoplasmata	F	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS2_k127_2071963_3	273116.14325602	1.205e-115	381.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,241PJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Putative diphthamide synthesis protein	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
MMS2_k127_2071963_2	263820.PTO0429	2.178e-136	445.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,241MG@183967|Thermoplasmata	183967|Thermoplasmata	J	Uncharacterized protein family UPF0004	-	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
MMS2_k127_2089402_10	673860.AciM339_0463	1.063e-15	83.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
MMS2_k127_2089402_9	273075.Ta0843	8.044e-16	78.0	arCOG05368@1|root,arCOG05368@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2089402_3	273075.Ta0841	3.114e-110	366.0	COG1064@1|root,arCOG01455@2157|Archaea,2XT0X@28890|Euryarchaeota,241ZZ@183967|Thermoplasmata	183967|Thermoplasmata	C	Zinc-binding dehydrogenase	-	-	1.3.1.84	ko:K15020	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00375	R00919	RC00095	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS2_k127_2089402_1	273075.Ta1145	1.994e-136	444.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota,241KX@183967|Thermoplasmata	183967|Thermoplasmata	H	Quinolinate phosphoribosyl transferase, C-terminal domain	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C
MMS2_k127_2089402_6	439481.Aboo_1314	1.541e-37	148.0	COG1335@1|root,arCOG01943@2157|Archaea,2XU2B@28890|Euryarchaeota,3F2UU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	Q	Isochorismatase family	entB2	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
MMS2_k127_2089402_2	273116.14325506	6.016e-126	417.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,241IS@183967|Thermoplasmata	183967|Thermoplasmata	J	cysteine-tRNA ligase activity	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
MMS2_k127_2089402_5	273116.14325051	6.771e-48	176.0	COG1956@1|root,arCOG05374@2157|Archaea,2Y497@28890|Euryarchaeota,242AW@183967|Thermoplasmata	183967|Thermoplasmata	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
MMS2_k127_2089402_7	263820.PTO1423	2.257e-35	141.0	COG0406@1|root,arCOG01991@2157|Archaea,2Y23H@28890|Euryarchaeota,2428S@183967|Thermoplasmata	183967|Thermoplasmata	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
MMS2_k127_2089402_4	1006006.Mcup_2000	3.276e-96	329.0	COG1055@1|root,arCOG00238@2157|Archaea	2157|Archaea	P	Citrate transporter	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
MMS2_k127_2089402_0	436114.SYO3AOP1_0787	4.013e-183	595.0	COG1331@1|root,COG1331@2|Bacteria,2G3SJ@200783|Aquificae	200783|Aquificae	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
MMS2_k127_2089402_11	273116.14325120	1.827e-11	72.0	arCOG05382@1|root,arCOG05382@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2089402_8	273075.Ta0925	1.002e-18	86.0	arCOG05387@1|root,arCOG05387@2157|Archaea,2Y1EF@28890|Euryarchaeota,242GU@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2128725_3	263820.PTO0838	6.178e-81	280.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,241UZ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_2128725_1	273075.Ta0528	5.165e-123	403.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,241Q2@183967|Thermoplasmata	183967|Thermoplasmata	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
MMS2_k127_2128725_0	273075.Ta0529m	1.22e-139	453.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,241M6@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_2128725_2	273116.14324806	1.051e-108	356.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,241SF@183967|Thermoplasmata	183967|Thermoplasmata	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
MMS2_k127_2128725_4	273116.14324805	5.774e-33	139.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,241SI@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS2_k127_2134335_1	263820.PTO0211	2.045e-28	119.0	COG0616@1|root,arCOG01311@2157|Archaea,2XTG8@28890|Euryarchaeota,2428N@183967|Thermoplasmata	183967|Thermoplasmata	O	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMS2_k127_2134335_2	795359.TOPB45_1098	1.528e-22	106.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recB	-	3.6.4.12	ko:K03657,ko:K16898	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF3799,PDDEXK_1,UvrD-helicase,UvrD_C
MMS2_k127_2134335_0	521460.Athe_0393	3.094e-163	531.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,42FYF@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
MMS2_k127_2148200_2	263820.PTO0201	6.935e-79	271.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,2424W@183967|Thermoplasmata	183967|Thermoplasmata	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_2148200_5	273116.14324349	3.037e-55	201.0	COG0164@1|root,arCOG04121@2157|Archaea,2XWYC@28890|Euryarchaeota,241S2@183967|Thermoplasmata	183967|Thermoplasmata	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
MMS2_k127_2148200_3	273116.14324257	3.326e-71	247.0	COG0457@1|root,arCOG03032@2157|Archaea,2Y7M7@28890|Euryarchaeota,2427N@183967|Thermoplasmata	183967|Thermoplasmata	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
MMS2_k127_2148200_8	273057.SSO1591	2.247e-29	127.0	arCOG05339@1|root,arCOG05339@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2148200_10	1304275.C41B8_16549	1.654e-06	57.0	2C8ZV@1|root,32RN8@2|Bacteria,1N1CN@1224|Proteobacteria,1S9IE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2148200_4	273116.14325284	1.905e-70	246.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,241S8@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
MMS2_k127_2148200_1	273116.14325283	4.694e-125	413.0	COG0025@1|root,arCOG01961@2157|Archaea,2XT52@28890|Euryarchaeota,24223@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
MMS2_k127_2148200_0	439481.Aboo_0009	1.217e-137	454.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,3F2TI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II/IV secretion system protein	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS2_k127_2148200_7	439481.Aboo_0008	1.383e-40	160.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F37F@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS2_k127_2148200_6	439481.Aboo_0007	6.863e-48	191.0	COG2064@1|root,arCOG01808@2157|Archaea,2XT4Q@28890|Euryarchaeota,3F36C@33867|unclassified Euryarchaeota	28890|Euryarchaeota	N	Type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
MMS2_k127_2148200_9	456442.Mboo_2355	8.822e-21	97.0	COG4962@1|root,arCOG01817@2157|Archaea,2XT4E@28890|Euryarchaeota,2N969@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM type II secretion system protein E	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
MMS2_k127_217777_1	1283283.ATXA01000010_gene4498	9.223e-46	169.0	COG3832@1|root,COG3832@2|Bacteria,2IRUM@201174|Actinobacteria,4EVXE@85013|Frankiales	201174|Actinobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS2_k127_217777_0	263820.PTO0243	1.022e-128	420.0	COG0750@1|root,arCOG00609@2157|Archaea,2XT29@28890|Euryarchaeota,241Y5@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_217777_2	263820.PTO0242	3.655e-34	141.0	COG1630@1|root,arCOG00367@2157|Archaea,2Y3KS@28890|Euryarchaeota,2427K@183967|Thermoplasmata	183967|Thermoplasmata	L	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
MMS2_k127_2202253_0	251221.35212100	5.331e-181	593.0	COG1501@1|root,COG1501@2|Bacteria,1G4DY@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
MMS2_k127_2219711_0	273116.14324230	6.153e-118	390.0	COG0138@1|root,arCOG02824@2157|Archaea,2XT5P@28890|Euryarchaeota,241IY@183967|Thermoplasmata	183967|Thermoplasmata	F	AICARFT/IMPCHase bienzyme	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
MMS2_k127_2219711_1	273116.14324232	1.359e-57	212.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2427H@183967|Thermoplasmata	183967|Thermoplasmata	S	Presenilin, signal peptide peptidase, family	-	-	-	-	-	-	-	-	-	-	-	-	SPP
MMS2_k127_2219711_2	273075.Ta0063	5.991e-52	186.0	COG0550@1|root,arCOG01527@2157|Archaea,2XU6T@28890|Euryarchaeota,241KQ@183967|Thermoplasmata	183967|Thermoplasmata	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
MMS2_k127_2221663_19	1123501.KB902283_gene2285	1.62e-13	75.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U256@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	4.2.1.83	ko:K10220	ko00362,ko01120,map00362,map01120	-	R04478	RC00498	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
MMS2_k127_2221663_6	273057.SSO2773	1.249e-90	308.0	COG0179@1|root,arCOG00235@2157|Archaea,2XQQH@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
MMS2_k127_2221663_8	671065.MetMK1DRAFT_00007660	1.72e-79	278.0	COG1917@1|root,arCOG02994@2157|Archaea	2157|Archaea	JM	conserved protein, contains double-stranded beta-helix domain	-	-	1.13.11.4,4.2.1.108	ko:K00450,ko:K06720	ko00260,ko00350,ko01100,ko01120,map00260,map00350,map01100,map01120	M00033	R02656,R06979	RC00764,RC01729	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupin_2,Ectoine_synth
MMS2_k127_2221663_14	326427.Cagg_2410	3.002e-39	156.0	COG0596@1|root,COG0596@2|Bacteria,2G6VQ@200795|Chloroflexi,377CS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS2_k127_2221663_20	1349785.BAUG01000008_gene689	6.928e-13	80.0	COG0715@1|root,COG0715@2|Bacteria,4NETN@976|Bacteroidetes,1HYVJ@117743|Flavobacteriia	976|Bacteroidetes	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
MMS2_k127_2221663_17	1944.JOAZ01000033_gene144	3.855e-22	106.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria,419KJ@629295|Streptomyces griseus group	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15552	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	BPD_transp_1
MMS2_k127_2221663_16	1509403.GW12_20690	4.487e-23	108.0	COG0600@1|root,COG0600@2|Bacteria,1N4HG@1224|Proteobacteria,1S2C9@1236|Gammaproteobacteria,3NMEK@468|Moraxellaceae	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
MMS2_k127_2221663_10	521011.Mpal_1075	2.438e-73	256.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
MMS2_k127_2221663_1	1134413.ANNK01000087_gene236	3.34e-154	494.0	2A6Y1@1|root,30VSZ@2|Bacteria,1UBKQ@1239|Firmicutes,4IN0U@91061|Bacilli,1ZMG5@1386|Bacillus	91061|Bacilli	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS2_k127_2221663_21	1120925.F941_01394	0.0002483	50.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,3NNMS@468|Moraxellaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_2221663_7	1120972.AUMH01000002_gene2755	3.848e-88	294.0	COG3435@1|root,COG3435@2|Bacteria	2|Bacteria	Q	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS2_k127_2221663_5	1120972.AUMH01000002_gene2756	1.847e-92	307.0	2F1RH@1|root,33URM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Auxin_BP,Cupin_2
MMS2_k127_2221663_3	333138.LQ50_20170	1.712e-112	381.0	COG4819@1|root,COG4819@2|Bacteria,1TQ6T@1239|Firmicutes,4HAEM@91061|Bacilli,1ZDKX@1386|Bacillus	91061|Bacilli	E	Ethanolamine utilisation protein EutA	eutA	-	-	ko:K04019	ko00564,ko01100,map00564,map01100	-	R00749	RC00370	ko00000,ko00001	-	-	-	EutA
MMS2_k127_2221663_11	485913.Krac_10571	2.181e-60	219.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS2_k127_2221663_12	471852.Tcur_4234	5.62e-60	212.0	COG2080@1|root,COG2080@2|Bacteria,2GK8J@201174|Actinobacteria,4EINF@85012|Streptosporangiales	201174|Actinobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS2_k127_2221663_0	1408254.T458_21695	1.396e-159	531.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,4HC1W@91061|Bacilli,26S7Z@186822|Paenibacillaceae	91061|Bacilli	C	Xanthine dehydrogenase	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS2_k127_2221663_13	1229909.NSED_01010	7.141e-60	217.0	COG1801@1|root,arCOG04291@2157|Archaea,41T6J@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS2_k127_2221663_4	1408473.JHXO01000008_gene2710	1.691e-94	335.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FN74@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
MMS2_k127_2221663_2	1172188.KB911820_gene2145	5.533e-114	390.0	COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4FF06@85021|Intrasporangiaceae	201174|Actinobacteria	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,oligo_HPY
MMS2_k127_2221663_15	1382306.JNIM01000001_gene3640	4.544e-36	156.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_2221663_9	263820.PTO1448	1.222e-78	274.0	COG0601@1|root,arCOG00751@2157|Archaea,2XTUV@28890|Euryarchaeota,241ZN@183967|Thermoplasmata	183967|Thermoplasmata	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_2221663_18	926564.KI911715_gene2675	2.347e-21	100.0	COG1173@1|root,COG1173@2|Bacteria,2HF2D@201174|Actinobacteria,4F5A0@85017|Promicromonosporaceae	201174|Actinobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_2260613_1	273116.14325351	1.657e-79	266.0	COG1405@1|root,arCOG01981@2157|Archaea,2XU76@28890|Euryarchaeota,2422B@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbB	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS2_k127_2260613_2	263820.PTO1339	3.725e-08	57.0	COG3277@1|root,arCOG02466@2157|Archaea	2157|Archaea	J	RNA-binding protein involved in rRNA processing	gar1	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
MMS2_k127_2260613_0	263820.PTO1338	2.588e-178	561.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,241JU@183967|Thermoplasmata	183967|Thermoplasmata	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfbA	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
MMS2_k127_2297668_1	273075.Ta0085m	3.63e-135	436.0	COG4948@1|root,arCOG01168@2157|Archaea,2XTSG@28890|Euryarchaeota,24211@183967|Thermoplasmata	183967|Thermoplasmata	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	GO:0003674,GO:0003824,GO:0008869,GO:0016829,GO:0016835,GO:0016836,GO:0047929	4.2.1.140	ko:K05308	ko00030,ko00052,ko01100,ko01120,ko01200,map00030,map00052,map01100,map01120,map01200	M00308,M00309,M00633	R01538,R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS2_k127_2297668_0	273116.14324403	0.0	1056.0	COG1048@1|root,arCOG01697@2157|Archaea,2XTIZ@28890|Euryarchaeota,241JD@183967|Thermoplasmata	183967|Thermoplasmata	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
MMS2_k127_2297668_3	263820.PTO1417	2.721e-63	229.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,241RN@183967|Thermoplasmata	183967|Thermoplasmata	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
MMS2_k127_2297668_2	330779.Saci_1679	5.238e-114	374.0	COG1506@1|root,arCOG01646@2157|Archaea,2XQ5P@28889|Crenarchaeota	28889|Crenarchaeota	E	prolyl oligopeptidase active site domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
MMS2_k127_233153_2	273057.SSO2130	1.796e-24	104.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPVE@28889|Crenarchaeota	28889|Crenarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS2_k127_233153_1	273075.Ta1491	4.198e-52	187.0	arCOG03678@1|root,arCOG03678@2157|Archaea,2XZ63@28890|Euryarchaeota,241VC@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_233153_0	273116.14325764	1.231e-249	782.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,241KJ@183967|Thermoplasmata	183967|Thermoplasmata	E	Possible Fer4-like domain in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
MMS2_k127_2383168_4	263820.PTO1221	5.879e-22	94.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,241PM@183967|Thermoplasmata	183967|Thermoplasmata	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS2_k127_2383168_0	273075.Ta1030	3.329e-104	345.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,241P6@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
MMS2_k127_2383168_1	273116.14325301	2.562e-88	301.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,241Q7@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
MMS2_k127_2383168_2	263820.PTO0192	1.641e-41	157.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,241V3@183967|Thermoplasmata	183967|Thermoplasmata	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
MMS2_k127_2383168_3	204669.Acid345_0006	3.027e-34	136.0	COG1970@1|root,COG1970@2|Bacteria,3Y58F@57723|Acidobacteria,2JJRP@204432|Acidobacteriia	204432|Acidobacteriia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
MMS2_k127_2383168_5	1232430.CAVG010000065_gene662	8.287e-09	57.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,4GWXT@90964|Staphylococcaceae	91061|Bacilli	C	Belongs to the citrate synthase family	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS2_k127_2386721_6	572478.Vdis_1036	2.448e-29	122.0	COG3371@1|root,arCOG02008@2157|Archaea,2XRYZ@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_2386721_0	273075.Ta1418m	2.218e-167	545.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,241KK@183967|Thermoplasmata	183967|Thermoplasmata	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
MMS2_k127_2386721_1	273075.Ta1419	3.515e-90	306.0	COG0166@1|root,arCOG00052@2157|Archaea,2XYUK@28890|Euryarchaeota,241R6@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS,bact-PGI_C
MMS2_k127_2386721_3	263820.PTO0414	2.768e-50	187.0	COG3885@1|root,arCOG01729@2157|Archaea,2XYMU@28890|Euryarchaeota,2428X@183967|Thermoplasmata	183967|Thermoplasmata	Q	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	LigB
MMS2_k127_2386721_2	273075.Ta1097	5.551e-62	219.0	COG3374@1|root,arCOG04349@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF981)	-	-	-	ko:K08980	-	-	-	-	ko00000	-	-	-	DUF981
MMS2_k127_2386721_5	273075.Ta0293	5.335e-30	123.0	COG2050@1|root,arCOG00777@2157|Archaea,2Y5G5@28890|Euryarchaeota,242FC@183967|Thermoplasmata	183967|Thermoplasmata	Q	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
MMS2_k127_2386721_4	273075.Ta0889	1.083e-33	134.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,241PQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS2_k127_2453643_1	521460.Athe_0573	1.143e-39	154.0	COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,24HGD@186801|Clostridia,42GJQ@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM cyclase family protein	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
MMS2_k127_2453643_5	263820.PTO0520	1.002e-07	54.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,241TG@183967|Thermoplasmata	183967|Thermoplasmata	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
MMS2_k127_2453643_4	263820.PTO0795	8.998e-22	102.0	COG0640@1|root,arCOG01687@2157|Archaea,2Y3JE@28890|Euryarchaeota,2425P@183967|Thermoplasmata	183967|Thermoplasmata	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2453643_0	1006006.Mcup_0700	2.666e-67	244.0	COG0477@1|root,arCOG00135@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_2453643_2	876269.ARWA01000001_gene3594	6.908e-31	128.0	COG3832@1|root,COG3832@2|Bacteria,1N3W1@1224|Proteobacteria,2VFMP@28211|Alphaproteobacteria,3ND0M@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
MMS2_k127_2453643_3	485913.Krac_6293	1.587e-25	108.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HTH_20,HTH_5,Methyltransf_11
MMS2_k127_2453643_7	933801.Ahos_0171	1.735e-06	60.0	arCOG07231@1|root,arCOG07231@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2453643_6	429009.Adeg_1610	2.546e-07	62.0	COG0500@1|root,COG2226@2|Bacteria,1U9IT@1239|Firmicutes,25BKT@186801|Clostridia	186801|Clostridia	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_2460803_0	397948.Cmaq_1209	1.223e-71	249.0	COG1058@1|root,arCOG00215@2157|Archaea,2XQA2@28889|Crenarchaeota	28889|Crenarchaeota	S	molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
MMS2_k127_2460803_1	273063.STK_25110	1.143e-56	206.0	COG0412@1|root,arCOG01659@2157|Archaea,2XRM2@28889|Crenarchaeota	28889|Crenarchaeota	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
MMS2_k127_2496667_0	273075.Ta1081	1.121e-296	921.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,241JF@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively	-	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
MMS2_k127_2496667_3	273075.Ta0824	1.935e-117	390.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,241MM@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
MMS2_k127_2496667_2	273116.14324767	7.869e-118	399.0	COG3356@1|root,arCOG04351@2157|Archaea,2XVEY@28890|Euryarchaeota,2421B@183967|Thermoplasmata	183967|Thermoplasmata	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
MMS2_k127_2496667_5	273075.Ta1068	5.129e-70	250.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota,241ZX@183967|Thermoplasmata	183967|Thermoplasmata	S	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
MMS2_k127_2496667_4	273075.Ta0839	1.181e-79	287.0	COG0750@1|root,arCOG00609@2157|Archaea,2Y3DV@28890|Euryarchaeota,2425X@183967|Thermoplasmata	183967|Thermoplasmata	M	membrane-associated Zn-dependent proteases 1	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2496667_1	273116.14325050	7.687e-257	819.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,241UG@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS2_k127_2496667_6	263820.PTO1212	9.582e-28	115.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,241RY@183967|Thermoplasmata	183967|Thermoplasmata	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
MMS2_k127_2531002_3	374847.Kcr_0621	5.56e-14	80.0	COG2253@1|root,arCOG03839@2157|Archaea	2157|Archaea	K	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	ko:K09144	-	-	-	-	ko00000	-	-	-	AbiEii
MMS2_k127_2531002_2	374847.Kcr_0622	1.834e-15	83.0	COG5340@1|root,arCOG04793@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_1,AbiEi_4
MMS2_k127_2531002_0	263820.PTO0542	1.964e-33	132.0	COG0143@1|root,arCOG00810@2157|Archaea,2XTG5@28890|Euryarchaeota,241JS@183967|Thermoplasmata	183967|Thermoplasmata	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g,tRNA_bind
MMS2_k127_2531002_1	263820.PTO0368	1.16e-29	122.0	COG3371@1|root,arCOG02008@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
MMS2_k127_2536469_8	545243.BAEV01000079_gene2983	2.428e-13	81.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS2_k127_2536469_5	273116.14325593	6.325e-50	190.0	COG1173@1|root,arCOG00748@2157|Archaea,2XUIX@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_2536469_6	1056495.Calag_0347	1.083e-19	101.0	COG0601@1|root,arCOG00751@2157|Archaea,2XQ40@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_2536469_1	273116.14325598	1.099e-253	793.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,241S7@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS2_k127_2536469_4	273075.Ta0260	2.174e-121	394.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,241Y9@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS2_k127_2536469_7	287986.DV20_33295	4.876e-14	84.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DXAU@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
MMS2_k127_2536469_2	273075.Ta0117	3.821e-198	623.0	COG0538@1|root,arCOG01164@2157|Archaea,2XTAR@28890|Euryarchaeota,241T3@183967|Thermoplasmata	183967|Thermoplasmata	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
MMS2_k127_2536469_3	273075.Ta1367m	2.98e-137	449.0	COG0104@1|root,arCOG04387@2157|Archaea,2XT59@28890|Euryarchaeota,241IP@183967|Thermoplasmata	183967|Thermoplasmata	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
MMS2_k127_2536469_0	273116.14325620	2.639e-278	863.0	COG2987@1|root,arCOG04670@2157|Archaea,2XT9Q@28890|Euryarchaeota,24215@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
MMS2_k127_2563689_11	273116.14325591	2.811e-62	228.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota	28890|Euryarchaeota	E	COG4608 ABC-type oligopeptide transport system, ATPase component	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
MMS2_k127_2563689_7	273075.Ta0174	2.289e-96	326.0	COG2107@1|root,arCOG00654@2157|Archaea,2XWEB@28890|Euryarchaeota,242FT@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
MMS2_k127_2563689_10	273075.Ta1351	9.339e-69	239.0	COG2236@1|root,arCOG00040@2157|Archaea,2XU0E@28890|Euryarchaeota,2425R@183967|Thermoplasmata	183967|Thermoplasmata	F	Phosphoribosyl transferase domain	-	-	2.4.2.22	ko:K00769,ko:K07101	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
MMS2_k127_2563689_4	263820.PTO0385	1.075e-103	344.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,241RS@183967|Thermoplasmata	183967|Thermoplasmata	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
MMS2_k127_2563689_12	263820.PTO0386	8.544e-43	167.0	COG0030@1|root,arCOG04131@2157|Archaea,2XU1Q@28890|Euryarchaeota,241VH@183967|Thermoplasmata	183967|Thermoplasmata	J	Ribosomal RNA adenine dimethylases	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
MMS2_k127_2563689_9	273116.14324531	2.592e-83	279.0	COG1491@1|root,arCOG04130@2157|Archaea,2XXAI@28890|Euryarchaeota,241Q5@183967|Thermoplasmata	183967|Thermoplasmata	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
MMS2_k127_2563689_17	273116.14324530	1.294e-08	60.0	COG1460@1|root,arCOG01016@2157|Archaea,2Y5MB@28890|Euryarchaeota,242FB@183967|Thermoplasmata	183967|Thermoplasmata	K	RNA polymerase	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
MMS2_k127_2563689_14	263820.PTO0389	3.256e-27	113.0	COG2139@1|root,arCOG04129@2157|Archaea,2XXZB@28890|Euryarchaeota,241X7@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
MMS2_k127_2563689_6	273116.14324528	1.586e-99	338.0	COG1258@1|root,arCOG01015@2157|Archaea,2XTTX@28890|Euryarchaeota,241NT@183967|Thermoplasmata	183967|Thermoplasmata	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	pus10	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP
MMS2_k127_2563689_16	273075.Ta1295a	4.539e-16	78.0	COG1996@1|root,arCOG04341@2157|Archaea,2Y1NC@28890|Euryarchaeota,242GH@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	-
MMS2_k127_2563689_13	263820.PTO0392	3.053e-35	135.0	COG1997@1|root,arCOG04208@2157|Archaea,2Y6HP@28890|Euryarchaeota,241TV@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
MMS2_k127_2563689_5	273116.14324526	4.608e-102	338.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,241N4@183967|Thermoplasmata	183967|Thermoplasmata	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS2_k127_2563689_3	273116.14324525	6.411e-109	357.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,241MB@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
MMS2_k127_2563689_8	273116.14324524	1.554e-93	311.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,241Q0@183967|Thermoplasmata	183967|Thermoplasmata	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1
MMS2_k127_2563689_0	273116.14325599	3.389e-202	640.0	COG1027@1|root,arCOG01750@2157|Archaea,2Y84P@28890|Euryarchaeota,2422A@183967|Thermoplasmata	183967|Thermoplasmata	E	Fumarase C C-terminus	-	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
MMS2_k127_2563689_1	263820.PTO0093	2.642e-166	536.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,24240@183967|Thermoplasmata	28890|Euryarchaeota	G	Sugar (and other) transporter	-	-	-	ko:K08176,ko:K08368,ko:K08369	-	-	-	-	ko00000,ko02000	2.A.1,2.A.1.9	-	-	MFS_1,Sugar_tr
MMS2_k127_2563689_15	997346.HMPREF9374_3637	9.274e-20	96.0	COG0454@1|root,COG0456@2|Bacteria,1VBEI@1239|Firmicutes,4HM9K@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	yokL	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_4
MMS2_k127_2563689_2	273075.Ta0830	3.43e-123	401.0	COG0596@1|root,arCOG01648@2157|Archaea,2XY7B@28890|Euryarchaeota,242EV@183967|Thermoplasmata	183967|Thermoplasmata	E	Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
MMS2_k127_2592224_1	273116.14324369	3.058e-44	171.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,241P5@183967|Thermoplasmata	183967|Thermoplasmata	J	histidyl-tRNA aminoacylation	hisS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
MMS2_k127_2592224_2	273116.14324513	1.086e-30	123.0	COG1522@1|root,arCOG01117@2157|Archaea,2Y6GC@28890|Euryarchaeota,242F4@183967|Thermoplasmata	183967|Thermoplasmata	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS2_k127_2592224_3	273116.14324512	6.439e-25	107.0	arCOG07411@1|root,arCOG07411@2157|Archaea,2Y1PB@28890|Euryarchaeota,242HJ@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2592224_0	263820.PTO1444	1.592e-80	275.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,241S5@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS2_k127_2592224_4	273075.Ta0534	1.067e-22	103.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,241JX@183967|Thermoplasmata	183967|Thermoplasmata	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
MMS2_k127_2594489_2	273075.Ta0364	4.414e-25	115.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,241WA@183967|Thermoplasmata	183967|Thermoplasmata	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
MMS2_k127_2594489_1	273075.Ta0363	4.022e-79	276.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,241PK@183967|Thermoplasmata	183967|Thermoplasmata	E	Semialdehyde dehydrogenase, NAD binding domain	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
MMS2_k127_2594489_0	273063.STK_05060	5.796e-107	358.0	COG0626@1|root,arCOG00060@2157|Archaea,2XPUN@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
MMS2_k127_2594489_3	1121382.JQKG01000051_gene2206	2.149e-10	66.0	COG0083@1|root,COG0083@2|Bacteria,1WID1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_261005_2	1056495.Calag_1003	4.791e-07	62.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_261005_0	263820.PTO0968	4.085e-102	346.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7A9@28890|Euryarchaeota,2420I@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_tranf_2_3
MMS2_k127_261005_1	673860.AciM339_0457	3.872e-89	306.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,3F38N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ1	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
MMS2_k127_2686386_2	273075.Ta1495	2.345e-17	85.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,241PD@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
MMS2_k127_2686386_1	263820.PTO0630	1.975e-65	235.0	COG0697@1|root,arCOG00271@2157|Archaea,2XVTF@28890|Euryarchaeota,2427P@183967|Thermoplasmata	183967|Thermoplasmata	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS2_k127_2686386_0	263820.PTO0454	3.099e-156	512.0	COG0343@1|root,COG1370@1|root,arCOG00989@2157|Archaea,arCOG00991@2157|Archaea,2XTFH@28890|Euryarchaeota,241KS@183967|Thermoplasmata	183967|Thermoplasmata	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PUA,TGT,TGT_C2
MMS2_k127_2734703_0	263820.PTO1015	7.163e-27	117.0	COG1814@1|root,arCOG01091@2157|Archaea,2Y4VZ@28890|Euryarchaeota,242DZ@183967|Thermoplasmata	183967|Thermoplasmata	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2734703_1	263820.PTO1016	4.276e-26	110.0	COG1888@1|root,arCOG04140@2157|Archaea,2Y6FP@28890|Euryarchaeota,242EC@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized ArCR, COG1888	-	-	-	ko:K09732	-	-	-	-	ko00000	-	-	-	DUF211
MMS2_k127_2770876_0	273116.14324966	1.298e-136	468.0	COG0210@1|root,arCOG00798@2157|Archaea,2Y7QM@28890|Euryarchaeota,2420G@183967|Thermoplasmata	183967|Thermoplasmata	L	UvrD/REP helicase N-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
MMS2_k127_2770876_1	1144275.COCOR_04334	7.938e-43	170.0	COG3281@1|root,COG3281@2|Bacteria,1NWMM@1224|Proteobacteria,43AJB@68525|delta/epsilon subdivisions,2X5ZN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
MMS2_k127_2798839_5	1347392.CCEZ01000043_gene185	4.964e-53	192.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,36DJ4@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS2_k127_2798839_2	945713.IALB_2668	7.013e-117	386.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
MMS2_k127_2798839_7	693661.Arcve_1638	8.137e-30	134.0	COG3372@1|root,arCOG04356@2157|Archaea,2XSTX@28890|Euryarchaeota	28890|Euryarchaeota	L	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
MMS2_k127_2798839_1	263820.PTO1322	2.101e-162	522.0	COG1061@1|root,arCOG00874@2157|Archaea,2XTYQ@28890|Euryarchaeota,2425B@183967|Thermoplasmata	183967|Thermoplasmata	L	ERCC3/RAD25/XPB C-terminal helicase	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,ResIII
MMS2_k127_2798839_6	263820.PTO0739	1.147e-35	139.0	COG0071@1|root,arCOG01832@2157|Archaea,2Y7BQ@28890|Euryarchaeota,242D8@183967|Thermoplasmata	183967|Thermoplasmata	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
MMS2_k127_2798839_0	273116.14325006	7.1e-189	603.0	COG0661@1|root,arCOG01189@2157|Archaea,2XT2I@28890|Euryarchaeota,24200@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
MMS2_k127_2798839_9	273075.Ta1355	8.6e-10	66.0	arCOG07410@1|root,arCOG07410@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2798839_4	263820.PTO0845	1.242e-68	239.0	COG0036@1|root,arCOG05046@2157|Archaea,2XVS8@28890|Euryarchaeota,241QM@183967|Thermoplasmata	183967|Thermoplasmata	G	Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
MMS2_k127_2798839_3	273075.Ta1316	2.734e-95	322.0	COG0604@1|root,arCOG01458@2157|Archaea,2XZIN@28890|Euryarchaeota,24247@183967|Thermoplasmata	183967|Thermoplasmata	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
MMS2_k127_2798839_10	397948.Cmaq_0355	1.047e-08	64.0	COG0454@1|root,arCOG00845@2157|Archaea	2157|Archaea	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1
MMS2_k127_2798839_8	263820.PTO0815	2.031e-17	83.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2Y6AX@28890|Euryarchaeota,242CM@183967|Thermoplasmata	183967|Thermoplasmata	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_2844618_5	397948.Cmaq_1153	2.205e-26	121.0	COG0477@1|root,arCOG00130@2157|Archaea,2XQP8@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_2844618_3	263820.PTO1420	1.839e-49	183.0	arCOG05407@1|root,arCOG05407@2157|Archaea,2Y3B8@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2844618_1	263820.PTO1419	8.117e-69	246.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTGJ@28890|Euryarchaeota,241TQ@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS2_k127_2844618_2	273116.14325448	1.611e-60	219.0	COG3390@1|root,arCOG02258@2157|Archaea,2Y7QP@28890|Euryarchaeota,241WM@183967|Thermoplasmata	183967|Thermoplasmata	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
MMS2_k127_2844618_7	999630.TUZN_0187	1.378e-05	50.0	arCOG02218@1|root,arCOG02218@2157|Archaea,2XRHK@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CcdA
MMS2_k127_2844618_6	1163730.FFONT_0656	3.793e-16	83.0	COG4113@1|root,arCOG00729@2157|Archaea,2XQZE@28889|Crenarchaeota	28889|Crenarchaeota	V	nucleic acid-binding protein contains PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS2_k127_2844618_0	273116.14324516	3.866e-200	633.0	COG1003@1|root,arCOG00076@2157|Archaea,2XT3V@28890|Euryarchaeota,241YN@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS2_k127_2844618_4	273075.Ta1358	2.722e-30	124.0	COG0403@1|root,arCOG00077@2157|Archaea,2XT39@28890|Euryarchaeota,24213@183967|Thermoplasmata	183967|Thermoplasmata	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS2_k127_2854981_1	745776.DGo_CA2264	6.876e-95	321.0	COG0372@1|root,COG0372@2|Bacteria,1WI65@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
MMS2_k127_2854981_0	273075.Ta0096	4.623e-141	461.0	COG0648@1|root,arCOG01894@2157|Archaea,2XU62@28890|Euryarchaeota,241P4@183967|Thermoplasmata	183967|Thermoplasmata	L	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
MMS2_k127_2854981_4	263820.PTO0615	6.538e-16	91.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y1TD@28890|Euryarchaeota,242GF@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2854981_2	273075.Ta1305	2.661e-69	246.0	COG3407@1|root,arCOG02937@2157|Archaea,2Y6X7@28890|Euryarchaeota,241XR@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative	-	GO:0003674,GO:0003824,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576	2.7.1.185	ko:K18689	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10779	RC00002,RC01439	ko00000,ko00001,ko01000	-	-	-	-
MMS2_k127_2854981_5	273075.Ta1302a	1.022e-13	73.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y1AH@28890|Euryarchaeota,242FI@183967|Thermoplasmata	183967|Thermoplasmata	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
MMS2_k127_2854981_3	273116.14325275	8.257e-26	110.0	COG3439@1|root,arCOG02761@2157|Archaea,2Y7BY@28890|Euryarchaeota,242F7@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
MMS2_k127_2854981_6	330779.Saci_0384	1.289e-06	53.0	COG4911@1|root,arCOG05495@2157|Archaea,2XSGC@28889|Crenarchaeota	28889|Crenarchaeota	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
MMS2_k127_2856166_1	263820.PTO0860	4.042e-135	437.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2420K@183967|Thermoplasmata	183967|Thermoplasmata	L	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS2_k127_2856166_2	263820.PTO0861	2.696e-104	353.0	COG0312@1|root,arCOG00322@2157|Archaea,2XVT5@28890|Euryarchaeota,2423P@183967|Thermoplasmata	183967|Thermoplasmata	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
MMS2_k127_2856166_0	263820.PTO0862	2.434e-162	531.0	COG0308@1|root,arCOG02969@2157|Archaea,2XVY4@28890|Euryarchaeota,24243@183967|Thermoplasmata	183967|Thermoplasmata	E	Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids	trf2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K13722	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
MMS2_k127_2860811_2	263820.PTO1520	1.258e-32	133.0	COG3375@1|root,arCOG04215@2157|Archaea,2Y3C8@28890|Euryarchaeota,2426D@183967|Thermoplasmata	183967|Thermoplasmata	M	carboxylic acid catabolic process	-	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_2860811_1	273075.Ta0086	3.148e-54	197.0	COG0491@1|root,arCOG00504@2157|Archaea,2Y7BK@28890|Euryarchaeota,242CU@183967|Thermoplasmata	183967|Thermoplasmata	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_2860811_0	1041930.Mtc_1660	1.995e-84	290.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
MMS2_k127_2861475_0	273116.14325288	1.327e-211	667.0	COG1012@1|root,arCOG01252@2157|Archaea,2XT1Y@28890|Euryarchaeota,24237@183967|Thermoplasmata	183967|Thermoplasmata	C	NADP-dependent dehydrogenase of the nED (non- phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D- glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3- phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006081,GO:0006082,GO:0006090,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009255,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016620,GO:0016903,GO:0019637,GO:0019682,GO:0019752,GO:0022607,GO:0032787,GO:0042802,GO:0042803,GO:0043436,GO:0043796,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0061678,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901575	1.2.1.89	ko:K18128	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R10615	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_2861475_2	593750.Metfor_2360	1.268e-33	143.0	arCOG06565@1|root,arCOG06565@2157|Archaea,2Y2CY@28890|Euryarchaeota,2NAAV@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2861475_3	1041930.Mtc_0404	6.333e-32	134.0	arCOG06564@1|root,arCOG06564@2157|Archaea,2Y1XQ@28890|Euryarchaeota,2NA3Q@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2861475_1	457570.Nther_2392	1.051e-65	232.0	COG4608@1|root,COG4608@2|Bacteria,1V1XB@1239|Firmicutes,24EQI@186801|Clostridia	186801|Clostridia	P	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_2913261_3	273063.STK_26070	8.409e-26	112.0	arCOG06030@1|root,arCOG06030@2157|Archaea,2XS4E@28889|Crenarchaeota	28889|Crenarchaeota	S	Ta0938	-	-	-	-	-	-	-	-	-	-	-	-	Ta0938
MMS2_k127_2913261_1	397948.Cmaq_0589	1.541e-74	261.0	COG5424@1|root,arCOG06031@2157|Archaea,2XRWB@28889|Crenarchaeota	28889|Crenarchaeota	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4,zf-C2H2_9
MMS2_k127_2913261_2	263820.PTO0059	2.589e-31	129.0	COG0500@1|root,arCOG05319@2157|Archaea	2157|Archaea	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_2913261_0	273075.Ta1319	4.897e-110	366.0	COG0044@1|root,arCOG00689@2157|Archaea,2XTQU@28890|Euryarchaeota,241MY@183967|Thermoplasmata	183967|Thermoplasmata	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
MMS2_k127_2933851_0	263820.PTO1161	2.934e-237	747.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2420R@183967|Thermoplasmata	183967|Thermoplasmata	V	Pfam:KH_3	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,T2SSE
MMS2_k127_2933851_1	263820.PTO0152	1.211e-97	329.0	COG0037@1|root,arCOG00042@2157|Archaea,2XTEZ@28890|Euryarchaeota,241N6@183967|Thermoplasmata	183967|Thermoplasmata	D	PP-loop family	-	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3
MMS2_k127_2941418_11	1056495.Calag_1003	0.0008576	48.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2941418_8	273116.14324453	2.837e-08	57.0	arCOG03675@1|root,arCOG06052@1|root,arCOG03675@2157|Archaea,arCOG06052@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB,Thermopsin
MMS2_k127_2941418_10	273075.Ta0564	0.0006373	44.0	COG0675@1|root,arCOG00679@2157|Archaea,2XWAB@28890|Euryarchaeota	28890|Euryarchaeota	L	TIGRFAM transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
MMS2_k127_2941418_7	330779.Saci_0467	2.832e-09	63.0	COG1487@1|root,arCOG02219@2157|Archaea	2157|Archaea	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
MMS2_k127_2941418_6	1365176.N186_09490	2.614e-09	65.0	COG1672@1|root,arCOG03166@2157|Archaea,2XQAZ@28889|Crenarchaeota	28889|Crenarchaeota	S	ATPase, AAA superfamily	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_14
MMS2_k127_2941418_9	368408.Tpen_1300	4.038e-06	52.0	COG2250@1|root,arCOG01191@2157|Archaea,2XR55@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
MMS2_k127_2941418_1	273116.14324434	1.083e-97	332.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS2_k127_2941418_0	273068.TTE2002	7.892e-139	457.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,42FD3@68295|Thermoanaerobacterales	186801|Clostridia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
MMS2_k127_2941418_5	273075.Ta1329	3.082e-41	172.0	COG0747@1|root,arCOG01534@2157|Archaea,2XXTQ@28890|Euryarchaeota,241XK@183967|Thermoplasmata	183967|Thermoplasmata	P	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_2941418_2	525904.Tter_2074	1.534e-74	261.0	COG0601@1|root,COG0601@2|Bacteria,2NQAZ@2323|unclassified Bacteria	2|Bacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_2941418_4	485913.Krac_2593	1.718e-58	215.0	COG1173@1|root,COG1173@2|Bacteria,2G88M@200795|Chloroflexi	2|Bacteria	EP	COGs COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02031,ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,BPD_transp_1,OppC_N,oligo_HPY
MMS2_k127_2941418_3	446465.Bfae_01350	1.013e-65	231.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4FDFP@85020|Dermabacteraceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_2960119_2	399795.CtesDRAFT_PD4986	4.689e-80	276.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,4A9UB@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
MMS2_k127_2960119_5	273116.14325496	2.326e-47	177.0	arCOG06972@1|root,arCOG06972@2157|Archaea,2Y4W6@28890|Euryarchaeota,242C4@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_2960119_1	273116.14325490	2.13e-99	332.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,241UJ@183967|Thermoplasmata	183967|Thermoplasmata	E	lyase activity	-	GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0008150,GO:0008152,GO:0008674,GO:0008675,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575	4.1.2.51,4.3.3.7	ko:K01714,ko:K18127	ko00030,ko00052,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00052,map00261,map00300,map01100,map01110,map01120,map01130,map01200,map01230	M00016,M00309,M00525,M00526,M00527	R08570,R10147,R10616	RC00307,RC00435,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS2_k127_2960119_4	273075.Ta1116	1.075e-49	180.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,241TC@183967|Thermoplasmata	183967|Thermoplasmata	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
MMS2_k127_2960119_6	263820.PTO1281	9.527e-31	121.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,241VA@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
MMS2_k127_2960119_8	273075.Ta1114	2.219e-19	89.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,241X3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
MMS2_k127_2960119_3	273075.Ta1113	1.354e-50	183.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,241SJ@183967|Thermoplasmata	183967|Thermoplasmata	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
MMS2_k127_2960119_0	273116.14324666	2.462e-217	689.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,241KA@183967|Thermoplasmata	183967|Thermoplasmata	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
MMS2_k127_2960119_7	263820.PTO1285	9.635e-28	123.0	COG0530@1|root,arCOG02881@2157|Archaea,2Y7DS@28890|Euryarchaeota,242GN@183967|Thermoplasmata	183967|Thermoplasmata	P	Sodium/calcium exchanger protein	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
MMS2_k127_3012103_3	263820.PTO1033	9.599e-65	229.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MB@28890|Euryarchaeota,24216@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K17314	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	ABC_tran
MMS2_k127_3012103_0	263820.PTO1036	2.495e-128	426.0	COG1653@1|root,arCOG00153@2157|Archaea,2Y3M5@28890|Euryarchaeota,24281@183967|Thermoplasmata	183967|Thermoplasmata	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17311	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	SBP_bac_1
MMS2_k127_3012103_4	263820.PTO1047	1.56e-43	168.0	COG0367@1|root,arCOG00071@2157|Archaea,2XSYP@28890|Euryarchaeota,241TS@183967|Thermoplasmata	183967|Thermoplasmata	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
MMS2_k127_3012103_2	263820.PTO0942	2.129e-107	353.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,241MI@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
MMS2_k127_3012103_1	273075.Ta0333	5.269e-126	411.0	COG1236@1|root,arCOG00541@2157|Archaea,2XTIU@28890|Euryarchaeota,241IR@183967|Thermoplasmata	183967|Thermoplasmata	J	Beta-Casp domain	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
MMS2_k127_306353_0	263820.PTO0374	3.736e-184	591.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,241KF@183967|Thermoplasmata	183967|Thermoplasmata	LT	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22
MMS2_k127_306353_2	273075.Ta0325	4.89e-52	192.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,241VI@183967|Thermoplasmata	183967|Thermoplasmata	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
MMS2_k127_306353_5	273116.14324632	4.377e-13	74.0	arCOG05351@1|root,arCOG05351@2157|Archaea,2Y1XZ@28890|Euryarchaeota,242GE@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF3198)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3198
MMS2_k127_306353_1	273116.14324633	4.393e-123	402.0	COG0421@1|root,arCOG00050@2157|Archaea,2XV5K@28890|Euryarchaeota,2422Q@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
MMS2_k127_306353_3	273075.Ta0093	4.118e-36	138.0	COG0776@1|root,arCOG05336@2157|Archaea,2XZF7@28890|Euryarchaeota,242BD@183967|Thermoplasmata	183967|Thermoplasmata	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
MMS2_k127_306353_4	1230341.MJ3_04964	4.136e-22	98.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4HA7P@91061|Bacilli	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
MMS2_k127_3085660_1	186497.PF1725	1.397e-84	293.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,242MR@183968|Thermococci	183968|Thermococci	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
MMS2_k127_3085660_0	273075.Ta0098	4.737e-228	715.0	COG0466@1|root,arCOG02162@2157|Archaea,2XVMC@28890|Euryarchaeota,241M7@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP-dependent peptidase activity	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA_32,Mg_chelatase,Sigma54_activat
MMS2_k127_3085660_2	273116.14325657	1.835e-51	189.0	COG2345@1|root,arCOG01691@2157|Archaea,2Y7BG@28890|Euryarchaeota,242BG@183967|Thermoplasmata	183967|Thermoplasmata	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
MMS2_k127_3094328_2	273116.14325318	5.422e-59	208.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,24220@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
MMS2_k127_3094328_1	273075.Ta0844	6.404e-69	242.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,24282@183967|Thermoplasmata	183967|Thermoplasmata	H	ThiF family	-	-	2.7.7.80	ko:K21029,ko:K22132	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiF
MMS2_k127_3094328_0	263820.PTO1121	2.04e-196	633.0	COG1529@1|root,arCOG01167@2157|Archaea,2XSZN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
MMS2_k127_3094328_3	1295642.H839_07794	7.202e-52	186.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4HINQ@91061|Bacilli	91061|Bacilli	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
MMS2_k127_31115_3	1041930.Mtc_2260	1.31e-07	54.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,2NBFS@224756|Methanomicrobia	224756|Methanomicrobia	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_31115_2	351160.LRC215	5.006e-29	125.0	COG1668@1|root,arCOG01462@2157|Archaea,2Y3YK@28890|Euryarchaeota	28890|Euryarchaeota	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_31115_0	933801.Ahos_0294	1.35e-94	319.0	COG1741@1|root,arCOG02935@2157|Archaea,2XRMP@28889|Crenarchaeota	28889|Crenarchaeota	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
MMS2_k127_31115_1	273075.Ta0551	1.707e-86	300.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,241N1@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
MMS2_k127_318182_1	666510.ASAC_0725	2.268e-64	233.0	COG1131@1|root,arCOG00194@2157|Archaea,2XPNB@28889|Crenarchaeota	28889|Crenarchaeota	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_318182_6	879212.DespoDRAFT_03310	2.62e-08	63.0	COG1403@1|root,COG1403@2|Bacteria,1QE4E@1224|Proteobacteria	1224|Proteobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5,RRXRR
MMS2_k127_318182_0	273075.Ta0893	1.517e-83	293.0	COG3407@1|root,arCOG02937@2157|Archaea,2XUJ7@28890|Euryarchaeota,2426X@183967|Thermoplasmata	183967|Thermoplasmata	I	isoprenoid metabolic process	-	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_318182_2	273116.14325083	3.441e-54	196.0	COG2074@1|root,arCOG01967@2157|Archaea,2Y11V@28890|Euryarchaeota,2427Z@183967|Thermoplasmata	183967|Thermoplasmata	F	AAA domain	-	GO:0003674,GO:0003824,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901564,GO:1901576	2.7.1.186	ko:K18690	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10780	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	AAA_18
MMS2_k127_318182_5	169963.lmo1117	1.257e-18	90.0	COG0346@1|root,COG0346@2|Bacteria,1U8NC@1239|Firmicutes,4IIK8@91061|Bacilli,26MR2@186820|Listeriaceae	91061|Bacilli	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_318182_4	521011.Mpal_0720	1.066e-29	122.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS2_k127_318182_3	1082933.MEA186_07002	6.924e-51	195.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,43IAS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
MMS2_k127_3185807_2	273116.14324968	4.927e-18	89.0	arCOG01916@1|root,arCOG01916@2157|Archaea,2Y4Q0@28890|Euryarchaeota,242BX@183967|Thermoplasmata	183967|Thermoplasmata	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
MMS2_k127_3185807_0	221288.JH992900_gene317	1.013e-174	566.0	COG3387@1|root,COG3387@2|Bacteria,1G3RH@1117|Cyanobacteria,1JKJ5@1189|Stigonemataceae	1117|Cyanobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
MMS2_k127_3185807_1	63737.Npun_F1795	7.256e-53	190.0	COG3387@1|root,COG3387@2|Bacteria,1G3RH@1117|Cyanobacteria,1HR83@1161|Nostocales	1117|Cyanobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
MMS2_k127_3199694_5	1278073.MYSTI_02322	3.411e-12	72.0	COG3214@1|root,COG3214@2|Bacteria,1R9AI@1224|Proteobacteria	1224|Proteobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
MMS2_k127_3199694_0	273075.Ta0676	3.463e-317	991.0	COG2366@1|root,arCOG04082@2157|Archaea,2XSYG@28890|Euryarchaeota	28890|Euryarchaeota	S	COG2366 Protein related to penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
MMS2_k127_3199694_3	273116.14325701	2.187e-36	139.0	COG1761@1|root,arCOG04111@2157|Archaea,2XZVZ@28890|Euryarchaeota,241XD@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
MMS2_k127_3199694_1	263820.PTO0412	7.729e-67	239.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,241RT@183967|Thermoplasmata	183967|Thermoplasmata	L	Putative RNA methylase family UPF0020	-	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	UPF0020
MMS2_k127_3199694_4	273075.Ta1086	1.041e-27	119.0	COG0576@1|root,arCOG04772@2157|Archaea,2Y6XU@28890|Euryarchaeota,241XI@183967|Thermoplasmata	183967|Thermoplasmata	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
MMS2_k127_3199694_2	263820.PTO0840	3.933e-46	168.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,241JG@183967|Thermoplasmata	183967|Thermoplasmata	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
MMS2_k127_3220042_0	273116.14325209	6.811e-106	367.0	COG5650@1|root,arCOG03702@2157|Archaea,2Y3AP@28890|Euryarchaeota,2423M@183967|Thermoplasmata	183967|Thermoplasmata	S	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3220042_1	273057.SSO3209	3.557e-79	273.0	COG0656@1|root,arCOG01619@2157|Archaea,2XPWK@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS2_k127_3220042_2	273075.Ta0231	1.739e-33	136.0	COG0746@1|root,arCOG01872@2157|Archaea,2Y4WY@28890|Euryarchaeota,242C0@183967|Thermoplasmata	183967|Thermoplasmata	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
MMS2_k127_3221871_3	273075.Ta0323m	3.93e-28	115.0	COG2125@1|root,arCOG01946@2157|Archaea,2XXZJ@28890|Euryarchaeota,241VJ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS6 family	rps6e	-	-	ko:K02991	ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S6e
MMS2_k127_3221871_0	263820.PTO0592	1.643e-185	587.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,241M1@183967|Thermoplasmata	183967|Thermoplasmata	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,eIF2_C
MMS2_k127_3221871_2	263820.PTO0593	9.821e-49	183.0	COG2231@1|root,arCOG00461@2157|Archaea,2Y86S@28890|Euryarchaeota,2428J@183967|Thermoplasmata	183967|Thermoplasmata	L	endonuclease III	-	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
MMS2_k127_3221871_1	273116.14325540	1.476e-86	291.0	COG0644@1|root,arCOG00570@2157|Archaea,2XV3Q@28890|Euryarchaeota,242AZ@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD dependent oxidoreductase	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO
MMS2_k127_3314930_1	263820.PTO1318	6.464e-62	223.0	COG0614@1|root,arCOG04233@2157|Archaea,2Y67J@28890|Euryarchaeota,2427C@183967|Thermoplasmata	183967|Thermoplasmata	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
MMS2_k127_3314930_0	1333998.M2A_0505	4.926e-80	273.0	COG2102@1|root,COG2102@2|Bacteria,1MUU2@1224|Proteobacteria,2U3M8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
MMS2_k127_3314930_2	273075.Ta0630m	1.343e-27	119.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota,242H2@183967|Thermoplasmata	183967|Thermoplasmata	Q	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_3314930_3	572546.Arcpr_0447	6.111e-13	75.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2469J@183980|Archaeoglobi	183980|Archaeoglobi	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
MMS2_k127_3340943_1	273116.14324888	1.627e-100	341.0	COG0249@1|root,arCOG02896@2157|Archaea,2Y7I3@28890|Euryarchaeota	28890|Euryarchaeota	L	This protein is involved in the repair of mismatches in DNA	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMS2_k127_3340943_0	273116.14324889	6.406e-133	441.0	COG0249@1|root,arCOG02897@2157|Archaea	2157|Archaea	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
MMS2_k127_3373491_2	399549.Msed_0974	9.436e-30	128.0	COG0428@1|root,arCOG00576@2157|Archaea	2157|Archaea	P	divalent heavy-metal cations transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	-
MMS2_k127_3373491_1	273116.14325695	6.755e-47	178.0	COG1120@1|root,arCOG00198@2157|Archaea,2XT76@28890|Euryarchaeota,242HX@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
MMS2_k127_3373491_0	273116.14324500	2.278e-98	333.0	COG0609@1|root,arCOG01007@2157|Archaea,2XT1A@28890|Euryarchaeota,241QA@183967|Thermoplasmata	183967|Thermoplasmata	P	FecCD transport family	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
MMS2_k127_3378921_4	273075.Ta0636	6.137e-104	347.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,241NW@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
MMS2_k127_3378921_11	930945.SiRe_2138	1.078e-28	123.0	arCOG03850@1|root,arCOG03850@2157|Archaea,2XS5M@28889|Crenarchaeota	28889|Crenarchaeota	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
MMS2_k127_3378921_8	273116.14325081	1.058e-70	246.0	COG2220@1|root,arCOG00497@2157|Archaea,2XTCN@28890|Euryarchaeota,241XY@183967|Thermoplasmata	183967|Thermoplasmata	S	hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
MMS2_k127_3378921_10	330779.Saci_0448	8.157e-32	132.0	COG1280@1|root,arCOG01947@2157|Archaea,2XS3S@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
MMS2_k127_3378921_3	397948.Cmaq_0785	1.687e-107	356.0	COG1013@1|root,arCOG01599@2157|Archaea,2XPQG@28889|Crenarchaeota	28889|Crenarchaeota	C	TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
MMS2_k127_3378921_0	263820.PTO1000	1.848e-249	784.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2422K@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
MMS2_k127_3378921_5	644966.Tmar_0462	4.671e-83	294.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3WDH0@538999|Clostridiales incertae sedis	186801|Clostridia	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
MMS2_k127_3378921_14	439481.Aboo_0914	6.8e-11	68.0	arCOG06692@1|root,arCOG06692@2157|Archaea,2Y53M@28890|Euryarchaeota,3F3HV@33867|unclassified Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3378921_9	273116.14324493	1.757e-63	223.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,241SP@183967|Thermoplasmata	183967|Thermoplasmata	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
MMS2_k127_3378921_6	273075.Ta1318m	7.359e-73	253.0	COG0047@1|root,arCOG00102@2157|Archaea,2XTPA@28890|Euryarchaeota,241Q4@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
MMS2_k127_3378921_12	439481.Aboo_1312	6.218e-16	78.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y6IG@28890|Euryarchaeota,3F2VU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Ribosomal_L40e	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
MMS2_k127_3378921_2	273075.Ta1274	1.137e-125	419.0	COG0750@1|root,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,241RB@183967|Thermoplasmata	183967|Thermoplasmata	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
MMS2_k127_3378921_1	263820.PTO0807	7.43e-192	604.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,241M4@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
MMS2_k127_3378921_13	1298867.AUES01000042_gene3572	2.1e-13	76.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,2TT5C@28211|Alphaproteobacteria,3JSIK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	coxM	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
MMS2_k127_3378921_7	1448860.BBJO01000031_gene410	3.201e-71	263.0	COG0843@1|root,arCOG01237@2157|Archaea,2XTBK@28890|Euryarchaeota,23S4J@183963|Halobacteria	183963|Halobacteria	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
MMS2_k127_3379947_0	263820.PTO0602	8.469e-81	283.0	COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,241VD@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
MMS2_k127_3379947_1	273075.Ta0283	1.062e-28	126.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,241WG@183967|Thermoplasmata	183967|Thermoplasmata	E	GHMP kinases N terminal domain	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
MMS2_k127_3379947_2	273075.Ta0284	2.085e-11	69.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,241V5@183967|Thermoplasmata	183967|Thermoplasmata	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
MMS2_k127_3398361_0	263820.PTO0505	1.181e-100	342.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,241NZ@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
MMS2_k127_3398361_1	263820.PTO0506	1.858e-99	326.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,241NQ@183967|Thermoplasmata	183967|Thermoplasmata	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbp	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
MMS2_k127_3398361_4	263820.PTO0507	5.972e-48	173.0	COG2151@1|root,arCOG01845@2157|Archaea,2Y0P6@28890|Euryarchaeota,242AR@183967|Thermoplasmata	183967|Thermoplasmata	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
MMS2_k127_3398361_2	273075.Ta1194	9.76e-73	256.0	COG1986@1|root,arCOG01221@2157|Archaea,2Y898@28890|Euryarchaeota,241PH@183967|Thermoplasmata	183967|Thermoplasmata	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like,NTPase_I-T
MMS2_k127_3398361_3	273116.14324619	1.922e-72	250.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,241ZA@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMS2_k127_3441861_1	263820.PTO1264	3.912e-27	123.0	COG0463@1|root,arCOG05398@2157|Archaea,2Y50K@28890|Euryarchaeota,242DT@183967|Thermoplasmata	183967|Thermoplasmata	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3441861_0	453591.Igni_0440	1.261e-82	287.0	COG0463@1|root,arCOG00894@2157|Archaea,2XQ9U@28889|Crenarchaeota	28889|Crenarchaeota	M	glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
MMS2_k127_3447420_4	1282876.BAOK01000001_gene3561	5.074e-07	56.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,4BR8E@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
MMS2_k127_3447420_2	397948.Cmaq_0908	7.176e-17	93.0	arCOG07425@1|root,arCOG07425@2157|Archaea	2157|Archaea	KLT	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD,Pkinase,Transglut_core
MMS2_k127_3447420_0	397948.Cmaq_0910	6.316e-132	429.0	COG0714@1|root,arCOG00434@2157|Archaea,2XPMH@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS2_k127_3447420_1	397948.Cmaq_0911	3.496e-61	227.0	COG1721@1|root,arCOG02742@2157|Archaea	2157|Archaea	S	protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS2_k127_3447420_3	273075.Ta0612	2.437e-12	67.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,241Q3@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
MMS2_k127_347201_3	178306.PAE0337	4.188e-22	102.0	COG4113@1|root,arCOG00727@2157|Archaea,2XS75@28889|Crenarchaeota	28889|Crenarchaeota	V	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
MMS2_k127_347201_2	1380346.JNIH01000071_gene4945	8.449e-44	163.0	COG0010@1|root,COG0010@2|Bacteria,2H81I@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the arginase family	argI	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS2_k127_347201_6	269797.Mbar_A1020	2.397e-10	63.0	arCOG03966@1|root,arCOG03966@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_347201_4	269797.Mbar_A1021	2.702e-17	84.0	COG2026@1|root,arCOG01663@2157|Archaea	2157|Archaea	DJ	Cytotoxic translational repressor of toxin-antitoxin stability system	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
MMS2_k127_347201_7	273075.Ta0231a	1.245e-08	58.0	arCOG06123@1|root,arCOG06123@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_347201_5	767029.HMPREF9154_2641	3.264e-12	72.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ACT,SnoaL_2
MMS2_k127_347201_1	273116.14324350	5.275e-52	184.0	arCOG00724@1|root,arCOG00724@2157|Archaea,2Y0MF@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PadR
MMS2_k127_35595_5	273075.Ta0026	1.731e-25	109.0	COG0498@1|root,arCOG01434@2157|Archaea,2XT84@28890|Euryarchaeota,2424F@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_35595_2	273075.Ta0022	9.419e-56	204.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,241QQ@183967|Thermoplasmata	183967|Thermoplasmata	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
MMS2_k127_35595_4	1462527.CCDM010000003_gene4240	1.057e-25	111.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,4HIG2@91061|Bacilli,23K8X@182709|Oceanobacillus	91061|Bacilli	FG	Protein similar to CwfJ C-terminus 1	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
MMS2_k127_35595_0	273075.Ta0040	9.509e-242	769.0	COG0525@1|root,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,241KT@183967|Thermoplasmata	183967|Thermoplasmata	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_35595_7	273075.Ta0032	8.402e-08	61.0	arCOG07354@1|root,arCOG07354@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_35595_1	263820.PTO0598	5.861e-234	739.0	COG3387@1|root,arCOG03286@2157|Archaea,2XUKJ@28890|Euryarchaeota,2421E@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyl hydrolases family 15	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
MMS2_k127_35595_3	330779.Saci_0184	4.375e-51	196.0	COG0337@1|root,arCOG00983@2157|Archaea,2XQB8@28889|Crenarchaeota	28889|Crenarchaeota	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
MMS2_k127_35595_6	231434.JQJH01000008_gene2765	4.294e-10	66.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,3N9N9@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
MMS2_k127_3561349_2	273116.14325477	1.623e-50	183.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,241VG@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS2_k127_3561349_1	1236689.MMALV_10200	5.577e-55	196.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,3F2K2@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	6,7-dimethyl-8-ribityllumazine synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMS2_k127_3561349_0	439481.Aboo_0745	7.594e-57	200.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,3F2P5@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
MMS2_k127_3576671_2	273075.Ta0646	1.775e-175	565.0	COG1960@1|root,arCOG04100@2157|Archaea,2XTBC@28890|Euryarchaeota,2422U@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
MMS2_k127_3576671_1	273116.14324732	1.702e-194	617.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2XUGF@28890|Euryarchaeota,24238@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_3576671_7	1056495.Calag_0558	1.371e-59	211.0	COG1335@1|root,arCOG01943@2157|Archaea,2XRXK@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS2_k127_3576671_0	263820.PTO0735	4.991e-257	801.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IK@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS2_k127_3576671_3	273075.Ta1332m	4.559e-151	486.0	COG0045@1|root,arCOG01337@2157|Archaea,2XTSC@28890|Euryarchaeota,24256@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP-grasp domain	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
MMS2_k127_3576671_4	273075.Ta1331	1.651e-126	409.0	COG0074@1|root,arCOG01339@2157|Archaea,2XTI3@28890|Euryarchaeota,24232@183967|Thermoplasmata	183967|Thermoplasmata	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
MMS2_k127_3576671_5	273116.14324487	4.345e-120	392.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,241JI@183967|Thermoplasmata	183967|Thermoplasmata	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	arcB	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
MMS2_k127_3576671_9	273075.Ta1321	1.049e-29	121.0	arCOG05358@1|root,arCOG05358@2157|Archaea,2Y1IF@28890|Euryarchaeota,242CT@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3576671_8	263820.PTO0718	9.528e-48	178.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,241V0@183967|Thermoplasmata	183967|Thermoplasmata	Q	Methyltransferase domain	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
MMS2_k127_3576671_6	1041930.Mtc_0963	1.056e-105	355.0	COG0798@1|root,arCOG02190@2157|Archaea,2XTQC@28890|Euryarchaeota,2N935@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
MMS2_k127_362311_2	273075.Ta0167	3.549e-18	99.0	arCOG03675@1|root,arCOG03675@2157|Archaea	2157|Archaea	S	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Thermopsin
MMS2_k127_362311_3	273057.SSO1901	8.201e-14	81.0	COG0500@1|root,arCOG01401@2157|Archaea,2XR2B@28889|Crenarchaeota	28889|Crenarchaeota	Q	TIGRFAM methyltransferase FkbM family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
MMS2_k127_362311_1	263820.PTO0778	1.023e-74	258.0	COG0013@1|root,arCOG01254@2157|Archaea,2Y3DT@28890|Euryarchaeota,2426U@183967|Thermoplasmata	183967|Thermoplasmata	J	Related to alanyl-tRNA synthetase HxxxH domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	-
MMS2_k127_362311_4	273116.14324981	5.066e-11	74.0	arCOG05363@1|root,arCOG05363@2157|Archaea,2Y4TQ@28890|Euryarchaeota,242DI@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_362311_5	273116.14324597	2.606e-07	56.0	arCOG07405@1|root,arCOG07405@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_362311_6	882378.RBRH_02898	3.666e-05	47.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VJJ7@28216|Betaproteobacteria,1K2F0@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_38,HTH_7,rve
MMS2_k127_362311_0	1162668.LFE_2212	7.83e-78	264.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
MMS2_k127_3625199_2	263820.PTO0129	1.723e-26	109.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,241PW@183967|Thermoplasmata	183967|Thermoplasmata	F	nicotinamide-nucleotide adenylyltransferase activity	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
MMS2_k127_3625199_0	263820.PTO1100	5.717e-128	420.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,241MR@183967|Thermoplasmata	183967|Thermoplasmata	E	Peptidase family M20/M25/M40	-	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
MMS2_k127_3625199_1	273075.Ta0937	4.461e-78	263.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,241KP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
MMS2_k127_3706538_4	273075.Ta0599	3.031e-08	56.0	COG1607@1|root,arCOG00773@2157|Archaea,2XXDM@28890|Euryarchaeota,24296@183967|Thermoplasmata	183967|Thermoplasmata	I	Thioesterase superfamily	-	-	3.1.2.20	ko:K01073	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
MMS2_k127_3706538_1	273116.14324853	1.63e-18	88.0	arCOG15086@1|root,arCOG15086@2157|Archaea,2Y5IR@28890|Euryarchaeota,242F8@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3706538_2	263820.PTO0903	2.429e-16	90.0	arCOG05369@1|root,arCOG05369@2157|Archaea,2Y5KQ@28890|Euryarchaeota,242GV@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3706538_0	273116.14324855	1.35e-25	122.0	COG0433@1|root,arCOG04034@2157|Archaea,2Y7QK@28890|Euryarchaeota,242BW@183967|Thermoplasmata	183967|Thermoplasmata	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
MMS2_k127_3706538_5	273075.Ta0590a	4.816e-08	58.0	arCOG05340@1|root,arCOG05340@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3706538_6	456320.Mvol_1183	6.094e-05	49.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MN@28890|Euryarchaeota,23QK6@183939|Methanococci	183939|Methanococci	G	PFAM ABC transporter related	-	-	3.6.3.55	ko:K15497	ko02010,map02010	M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5	-	-	ABC_tran
MMS2_k127_3735213_8	1231391.AMZF01000003_gene3182	2.327e-10	69.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2WG6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
MMS2_k127_3735213_1	273075.Ta1034	8.671e-85	295.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y7A7@28890|Euryarchaeota,241ZW@183967|Thermoplasmata	183967|Thermoplasmata	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_3735213_3	1134413.ANNK01000086_gene318	4.312e-76	267.0	COG0715@1|root,COG0715@2|Bacteria,1TXP3@1239|Firmicutes,4I6PJ@91061|Bacilli,1ZM9Z@1386|Bacillus	91061|Bacilli	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
MMS2_k127_3735213_4	1007103.AFHW01000091_gene3378	6.861e-61	219.0	COG1028@1|root,COG1028@2|Bacteria,1U2GS@1239|Firmicutes,4H9R9@91061|Bacilli,26QGX@186822|Paenibacillaceae	91061|Bacilli	IQ	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG1	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS2_k127_3735213_7	1169144.KB910951_gene3278	1.002e-14	84.0	COG3173@1|root,COG3173@2|Bacteria,1VE1X@1239|Firmicutes,4HM2B@91061|Bacilli,1ZGF6@1386|Bacillus	91061|Bacilli	S	Phosphotransferase enzyme family	aacA-aphD	-	2.7.1.190	ko:K17910	-	-	R11229	RC00002,RC00078	ko00000,ko01000,ko01504	-	-	-	APH
MMS2_k127_3735213_0	868595.Desca_2490	1.055e-160	515.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia,261WI@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_3735213_2	273116.14324953	2.118e-81	280.0	COG0657@1|root,arCOG02638@2157|Archaea,2XTFN@28890|Euryarchaeota,24278@183967|Thermoplasmata	183967|Thermoplasmata	I	Steryl acetyl hydrolase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
MMS2_k127_3735213_6	273116.14324813	7.024e-20	91.0	COG0241@1|root,arCOG07384@2157|Archaea,2Y0DK@28890|Euryarchaeota,242CA@183967|Thermoplasmata	183967|Thermoplasmata	E	Converts the D-glycero-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PNK3P
MMS2_k127_3736164_3	999630.TUZN_0748	7.838e-53	197.0	COG4946@1|root,arCOG03384@2157|Archaea,2XRSU@28889|Crenarchaeota	28889|Crenarchaeota	O	Tricorn protease homolog	-	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
MMS2_k127_3736164_2	930945.SiRe_0966	8.721e-77	271.0	COG0477@1|root,arCOG00130@2157|Archaea,2XRH0@28889|Crenarchaeota	28889|Crenarchaeota	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_3736164_1	273075.Ta0217	3.594e-145	468.0	COG1060@1|root,arCOG00656@2157|Archaea,2XW63@28890|Euryarchaeota	28890|Euryarchaeota	H	Radical SAM domain protein	-	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
MMS2_k127_3736164_0	273075.Ta0215	1.351e-153	492.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11781,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
MMS2_k127_3739485_0	985053.VMUT_0605	1.2e-114	386.0	COG1012@1|root,arCOG01252@2157|Archaea,2XPV3@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Aldehyde dehydrogenase	gapN	GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0008886,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.2.1.90	ko:K18978	ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200	M00308,M00633	R01058,R10860	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_3739485_1	69014.TK2188	2.327e-11	76.0	arCOG04615@1|root,arCOG04615@2157|Archaea,2Y2IE@28890|Euryarchaeota,244Z1@183968|Thermococci	183968|Thermococci	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
MMS2_k127_3769710_2	399549.Msed_1313	2.001e-19	89.0	arCOG07343@1|root,arCOG07343@2157|Archaea,2XS2D@28889|Crenarchaeota	28889|Crenarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3769710_0	273116.14324457	0.0	1424.0	COG0243@1|root,arCOG01492@2157|Archaea,2Y8AB@28890|Euryarchaeota,2425G@183967|Thermoplasmata	183967|Thermoplasmata	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
MMS2_k127_3769710_3	273075.Ta0424	1.044e-14	81.0	COG2427@1|root,arCOG07741@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS2_k127_3769710_1	263820.PTO1037	1.629e-71	250.0	COG1526@1|root,arCOG04358@2157|Archaea,2XYNI@28890|Euryarchaeota,2427S@183967|Thermoplasmata	183967|Thermoplasmata	H	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
MMS2_k127_3780598_6	263820.PTO0831	3.152e-09	66.0	arCOG08352@1|root,arCOG08352@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3780598_1	263820.PTO1105	1.76e-78	267.0	COG3620@1|root,arCOG00608@2157|Archaea,2XTDG@28890|Euryarchaeota,241RM@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
MMS2_k127_3780598_2	273116.14324401	9.979e-43	162.0	COG0575@1|root,arCOG04106@2157|Archaea,2XWNR@28890|Euryarchaeota,241V9@183967|Thermoplasmata	183967|Thermoplasmata	I	Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids	carS	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
MMS2_k127_3780598_3	263820.PTO1103	2.366e-37	143.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,241UF@183967|Thermoplasmata	183967|Thermoplasmata	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
MMS2_k127_3780598_0	273075.Ta0080	1.355e-122	404.0	COG0626@1|root,arCOG00060@2157|Archaea,2XT98@28890|Euryarchaeota,241P8@183967|Thermoplasmata	183967|Thermoplasmata	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
MMS2_k127_3780598_4	273075.Ta0081	6.093e-29	123.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,241UQ@183967|Thermoplasmata	183967|Thermoplasmata	F	dTDP metabolic process	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
MMS2_k127_3780598_5	273116.14324316	8.356e-23	98.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,241PI@183967|Thermoplasmata	183967|Thermoplasmata	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
MMS2_k127_3821973_1	273116.14324764	3.808e-83	283.0	arCOG05356@1|root,arCOG05356@2157|Archaea,2Y3A3@28890|Euryarchaeota,2421Y@183967|Thermoplasmata	183967|Thermoplasmata	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
MMS2_k127_3821973_3	263820.PTO0820	3.459e-14	74.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y7C3@28890|Euryarchaeota,242FZ@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps17e	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
MMS2_k127_3821973_2	273116.14324861	4.291e-33	132.0	COG0589@1|root,arCOG02053@2157|Archaea	2157|Archaea	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	ko:K20989	-	-	-	-	ko00000,ko02000	2.A.21.6	-	-	Usp
MMS2_k127_3821973_0	273075.Ta1088	1.363e-129	422.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,241ME@183967|Thermoplasmata	183967|Thermoplasmata	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
MMS2_k127_382896_1	273075.Ta1199	2.345e-119	388.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,241S4@183967|Thermoplasmata	183967|Thermoplasmata	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
MMS2_k127_382896_0	273116.14325244	0.0	1160.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,241RC@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
MMS2_k127_382896_2	273075.Ta0887	1.358e-51	191.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y72P@28890|Euryarchaeota,2428V@183967|Thermoplasmata	183967|Thermoplasmata	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
MMS2_k127_382896_3	273116.14325221	1.525e-50	188.0	COG0388@1|root,arCOG00062@2157|Archaea,2Y3PB@28890|Euryarchaeota,24280@183967|Thermoplasmata	183967|Thermoplasmata	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
MMS2_k127_382896_4	273075.Ta0889	3.639e-33	136.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,241PQ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
MMS2_k127_3839514_0	263820.PTO0578	2.971e-148	491.0	COG3408@1|root,arCOG03287@2157|Archaea,2Y7AG@28890|Euryarchaeota,2423D@183967|Thermoplasmata	183967|Thermoplasmata	G	Amylo-alpha-1,6-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C
MMS2_k127_3839514_1	263820.PTO1035	1.979e-21	99.0	COG1175@1|root,arCOG00157@2157|Archaea,2XU7E@28890|Euryarchaeota,2427U@183967|Thermoplasmata	183967|Thermoplasmata	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17312	ko02010,map02010	M00604	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.15	-	-	BPD_transp_1
MMS2_k127_3856476_1	572477.Alvin_2660	2.13e-66	237.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales	135613|Chromatiales	S	Methyltransferase	-	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
MMS2_k127_3856476_0	933115.GPDM_02615	2.009e-131	433.0	COG1262@1|root,COG1262@2|Bacteria,1TT4R@1239|Firmicutes,4HA8D@91061|Bacilli,26GER@186818|Planococcaceae	91061|Bacilli	S	Sulfatase-modifying factor enzyme 1	pkn1	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
MMS2_k127_3856476_4	273068.TTE1148	1.521e-21	97.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	yrkH	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
MMS2_k127_3856476_6	266835.14028256	9.792e-15	82.0	2F0BN@1|root,33TEV@2|Bacteria,1NQIP@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3856476_3	273075.Ta0854	4.323e-61	215.0	COG0279@1|root,arCOG05355@2157|Archaea,2XUSN@28890|Euryarchaeota,241VQ@183967|Thermoplasmata	183967|Thermoplasmata	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
MMS2_k127_3856476_2	273116.14325121	1.523e-65	243.0	COG3463@1|root,arCOG03812@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
MMS2_k127_3856476_5	1051632.TPY_0769	1.251e-18	91.0	COG3837@1|root,COG3837@2|Bacteria,1V9M6@1239|Firmicutes,24HEN@186801|Clostridia	186801|Clostridia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
MMS2_k127_3860476_16	273075.Ta1075	9.817e-34	132.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,241MF@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoglycerate kinase activity	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS2_k127_3860476_10	273116.14324744	3.146e-49	184.0	COG1208@1|root,arCOG00664@2157|Archaea,2Y46V@28890|Euryarchaeota,242A9@183967|Thermoplasmata	183967|Thermoplasmata	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
MMS2_k127_3860476_6	273116.14324743	1.756e-163	524.0	COG0451@1|root,arCOG04762@2157|Archaea,2XU8F@28890|Euryarchaeota,241XT@183967|Thermoplasmata	183967|Thermoplasmata	M	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_3860476_19	1121920.AUAU01000003_gene1181	1.047e-19	105.0	COG0515@1|root,COG0515@2|Bacteria,3Y6PF@57723|Acidobacteria	57723|Acidobacteria	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
MMS2_k127_3860476_15	1511.CLOST_1850	4.663e-35	144.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,25R6H@186804|Peptostreptococcaceae	186801|Clostridia	T	phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
MMS2_k127_3860476_12	234267.Acid_6266	2.76e-47	173.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
MMS2_k127_3860476_17	263820.PTO0525	1.2e-32	130.0	arCOG05345@1|root,arCOG05345@2157|Archaea,2Y117@28890|Euryarchaeota,242B3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_3860476_3	273075.Ta0222	6.141e-192	613.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,241K4@183967|Thermoplasmata	183967|Thermoplasmata	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B
MMS2_k127_3860476_9	1123508.JH636445_gene6877	1.212e-62	222.0	COG4122@1|root,COG4122@2|Bacteria,2J0TF@203682|Planctomycetes	203682|Planctomycetes	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
MMS2_k127_3860476_0	63737.Npun_F1795	8.639e-264	835.0	COG3387@1|root,COG3387@2|Bacteria,1G3RH@1117|Cyanobacteria,1HR83@1161|Nostocales	1117|Cyanobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
MMS2_k127_3860476_13	935948.KE386494_gene853	9.911e-42	160.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,42G30@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
MMS2_k127_3860476_4	439481.Aboo_0328	8.45e-190	604.0	COG0516@1|root,arCOG00612@2157|Archaea,2XU40@28890|Euryarchaeota,3F380@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
MMS2_k127_3860476_14	273116.14325641	2.956e-41	161.0	COG1427@1|root,arCOG00655@2157|Archaea,2Y266@28890|Euryarchaeota	28890|Euryarchaeota	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
MMS2_k127_3860476_7	673860.AciM339_0333	1.444e-91	310.0	COG0451@1|root,arCOG04468@2157|Archaea,2XT9R@28890|Euryarchaeota,3F346@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_3860476_5	273116.14324615	6.757e-178	565.0	COG0156@1|root,arCOG00113@2157|Archaea,2XUFG@28890|Euryarchaeota	28890|Euryarchaeota	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
MMS2_k127_3860476_8	263820.PTO0898	8.514e-73	251.0	COG0177@1|root,arCOG00459@2157|Archaea,2XTY1@28890|Euryarchaeota,241RZ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
MMS2_k127_3860476_18	693661.Arcve_2050	4.743e-20	102.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,245QU@183980|Archaeoglobi	183980|Archaeoglobi	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS2_k127_3860476_20	439481.Aboo_0579	3.63e-19	90.0	COG2768@1|root,arCOG02448@2157|Archaea,2Y7JX@28890|Euryarchaeota,3F2W9@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
MMS2_k127_3860476_1	263820.PTO0896	6.267e-208	651.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,241M8@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
MMS2_k127_3860476_2	263820.PTO0895	1.072e-194	617.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,241J3@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
MMS2_k127_3860476_11	1220589.CD32_07005	4.05e-48	184.0	COG0451@1|root,COG0451@2|Bacteria,1TR3K@1239|Firmicutes,4HD3P@91061|Bacilli,3IWM7@400634|Lysinibacillus	91061|Bacilli	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
MMS2_k127_3860476_21	904144.AEJD01000006_gene530	3.467e-15	81.0	COG1131@1|root,COG1131@2|Bacteria,2GJDP@201174|Actinobacteria,4D00Y@85004|Bifidobacteriales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_38668_9	273116.14324471	1.864e-16	82.0	COG0477@1|root,arCOG00132@2157|Archaea,2XW9U@28890|Euryarchaeota	28890|Euryarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3
MMS2_k127_38668_4	273075.Ta1304	1.207e-94	322.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7A1@28890|Euryarchaeota,241YY@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_38668_1	1094980.Mpsy_0403	2.803e-208	668.0	COG3808@1|root,arCOG04949@2157|Archaea,2XTDB@28890|Euryarchaeota,2N98C@224756|Methanomicrobia	224756|Methanomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
MMS2_k127_38668_8	273116.14324631	8.579e-23	102.0	COG3377@1|root,arCOG04424@2157|Archaea,2Y0SF@28890|Euryarchaeota,242ES@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1805)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1805
MMS2_k127_38668_0	273116.14324722	2.03e-253	791.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,241IM@183967|Thermoplasmata	183967|Thermoplasmata	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
MMS2_k127_38668_6	1132442.KB889752_gene837	6.095e-56	213.0	COG0578@1|root,COG0578@2|Bacteria,1TQJN@1239|Firmicutes,4HAG8@91061|Bacilli,1ZCGN@1386|Bacillus	91061|Bacilli	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.1.3.21,1.1.5.3	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	-	R00846,R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
MMS2_k127_38668_5	66874.JOFS01000033_gene637	1.213e-57	219.0	COG0277@1|root,COG0277@2|Bacteria,2GIS6@201174|Actinobacteria	201174|Actinobacteria	C	FAD linked	eapA	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS2_k127_38668_3	1120971.AUCA01000001_gene1638	1.85e-110	374.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli,278VH@186823|Alicyclobacillaceae	91061|Bacilli	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_38668_2	273116.14324613	2.023e-113	377.0	COG1454@1|root,arCOG00984@2157|Archaea,2XU9N@28890|Euryarchaeota	28890|Euryarchaeota	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
MMS2_k127_38668_7	273116.14324612	1.074e-48	177.0	COG3255@1|root,arCOG01842@2157|Archaea,2XXJM@28890|Euryarchaeota	28890|Euryarchaeota	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS2_k127_38668_11	399549.Msed_0458	5.542e-09	69.0	arCOG06052@1|root,arCOG06052@2157|Archaea	2157|Archaea	-	-	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CARDB
MMS2_k127_38668_10	374847.Kcr_0680	5.573e-13	82.0	arCOG02499@1|root,arCOG02499@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHB_HEX_C_1,NosD
MMS2_k127_3874812_1	263820.PTO0856	5.744e-175	590.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,241K1@183967|Thermoplasmata	183967|Thermoplasmata	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS2_k127_3874812_7	572546.Arcpr_0039	3.329e-06	57.0	COG1354@1|root,arCOG02610@2157|Archaea,2XT0N@28890|Euryarchaeota,2469Q@183980|Archaeoglobi	183980|Archaeoglobi	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
MMS2_k127_3874812_6	926550.CLDAP_10950	3.927e-21	100.0	COG1468@1|root,COG1468@2|Bacteria,2G6VA@200795|Chloroflexi	200795|Chloroflexi	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
MMS2_k127_3874812_3	263820.PTO0226	1.845e-113	376.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,241NP@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
MMS2_k127_3874812_5	439481.Aboo_0303	1.283e-36	145.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,3F2RE@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM indolepyruvate ferredoxin oxidoreductase, beta subunit	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
MMS2_k127_3874812_0	439481.Aboo_0302	2.6e-180	583.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,3F2HQ@33867|unclassified Euryarchaeota	28890|Euryarchaeota	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
MMS2_k127_3874812_2	263820.PTO0228	2.859e-114	377.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,241MU@183967|Thermoplasmata	183967|Thermoplasmata	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
MMS2_k127_3874812_4	273075.Ta1036	5.445e-72	248.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,241QP@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity)	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
MMS2_k127_3886030_2	1501230.ET33_19410	0.0003314	43.0	COG1028@1|root,COG1028@2|Bacteria,1V1E5@1239|Firmicutes,4IT4U@91061|Bacilli,276B7@186822|Paenibacillaceae	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.320	ko:K16216	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
MMS2_k127_3886030_0	273075.Ta0703	2.438e-76	275.0	COG2244@1|root,arCOG02209@2157|Archaea,2Y7AT@28890|Euryarchaeota,24273@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3,Polysacc_synt_C
MMS2_k127_3886030_1	273075.Ta0541	1.105e-13	72.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y695@28890|Euryarchaeota,241ZB@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_388848_0	263358.VAB18032_01995	7.348e-99	332.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4D98A@85008|Micromonosporales	201174|Actinobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_388848_3	929712.KI912613_gene173	1.124e-26	119.0	COG0842@1|root,COG0842@2|Bacteria,2GJ2G@201174|Actinobacteria,4CSXM@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
MMS2_k127_388848_2	582899.Hden_1503	6.027e-47	183.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
MMS2_k127_388848_1	649747.HMPREF0083_02280	1.437e-47	181.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_25
MMS2_k127_3928480_0	263820.PTO0976	4.677e-130	434.0	COG1132@1|root,arCOG02841@2157|Archaea,2XSW0@28890|Euryarchaeota,2426N@183967|Thermoplasmata	183967|Thermoplasmata	P	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_3928480_2	632292.Calhy_1212	1.102e-79	287.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42FVZ@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
MMS2_k127_3928480_1	743719.PaelaDRAFT_1328	3.502e-88	296.0	COG1028@1|root,COG1028@2|Bacteria,1VREU@1239|Firmicutes,4HUY2@91061|Bacilli,26WDM@186822|Paenibacillaceae	91061|Bacilli	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
MMS2_k127_3966526_3	273075.Ta0126	6.387e-109	369.0	COG2182@1|root,arCOG00154@2157|Archaea	2157|Archaea	G	PFAM extracellular solute-binding protein family 1	malE	-	-	ko:K15770	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	SBP_bac_8
MMS2_k127_3966526_5	273075.Ta0127	7.067e-98	329.0	COG1175@1|root,arCOG00157@2157|Archaea,2XW1I@28890|Euryarchaeota	28890|Euryarchaeota	P	COG1175 ABC-type sugar transport systems, permease components	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
MMS2_k127_3966526_4	273075.Ta0128	3.392e-105	349.0	COG3833@1|root,arCOG00160@2157|Archaea	2157|Archaea	P	PFAM binding-protein-dependent transport systems inner membrane component	malG	-	-	ko:K15772	ko02010,map02010	M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
MMS2_k127_3966526_1	273075.Ta0130	4.702e-113	376.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MN@28890|Euryarchaeota	28890|Euryarchaeota	E	COG3839 ABC-type sugar transport systems, ATPase components	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
MMS2_k127_3966526_0	273116.14325459	1.176e-165	537.0	COG0028@1|root,arCOG03656@2157|Archaea,2XSZ0@28890|Euryarchaeota,242I3@183967|Thermoplasmata	183967|Thermoplasmata	E	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS2_k127_3966526_2	273116.14325460	3.276e-112	368.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,242A2@183967|Thermoplasmata	183967|Thermoplasmata	H	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_3980995_2	930945.SiRe_2197	3.682e-76	269.0	COG0444@1|root,arCOG05410@2157|Archaea,2XSPB@28889|Crenarchaeota	28889|Crenarchaeota	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_3980995_1	666510.ASAC_0772	3.003e-97	343.0	COG1501@1|root,arCOG03663@2157|Archaea,2XRT3@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF5110,Gal_mutarotas_2,Glyco_hydro_31
MMS2_k127_3980995_0	933801.Ahos_0325	2.338e-160	512.0	COG4948@1|root,arCOG01168@2157|Archaea	2157|Archaea	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	gnaD	-	4.2.1.140,4.2.1.6,4.2.1.82	ko:K01684,ko:K05308,ko:K14275	ko00030,ko00040,ko00052,ko01100,ko01120,ko01200,map00030,map00040,map00052,map01100,map01120,map01200	M00308,M00309,M00552,M00633	R01538,R02429,R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
MMS2_k127_4009871_2	263820.PTO1498	3.387e-65	232.0	COG1277@1|root,arCOG03690@2157|Archaea,2Y1XM@28890|Euryarchaeota,2427A@183967|Thermoplasmata	183967|Thermoplasmata	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_4009871_1	273116.14325205	9.218e-75	261.0	COG1131@1|root,arCOG00194@2157|Archaea,2XUG5@28890|Euryarchaeota,241YW@183967|Thermoplasmata	183967|Thermoplasmata	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
MMS2_k127_4009871_0	273075.Ta0639	2.212e-144	472.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,241IU@183967|Thermoplasmata	183967|Thermoplasmata	J	phenylalanine-tRNA ligase activity	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
MMS2_k127_4009871_3	1536774.H70357_20815	1.626e-07	53.0	COG1733@1|root,COG1733@2|Bacteria,1VXAU@1239|Firmicutes,4HXM8@91061|Bacilli,26YU5@186822|Paenibacillaceae	91061|Bacilli	K	transcriptional	yvaP1	-	-	-	-	-	-	-	-	-	-	-	HxlR
MMS2_k127_4021339_2	273075.Ta0577	4.108e-92	310.0	COG0665@1|root,arCOG00755@2157|Archaea,2Y66F@28890|Euryarchaeota,24239@183967|Thermoplasmata	183967|Thermoplasmata	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
MMS2_k127_4021339_0	273116.14324868	3.833e-225	708.0	COG1012@1|root,arCOG01252@2157|Archaea,2XVV5@28890|Euryarchaeota,241TP@183967|Thermoplasmata	183967|Thermoplasmata	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
MMS2_k127_4021339_4	639283.Snov_0175	5.379e-24	113.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2TRE1@28211|Alphaproteobacteria,3EZ2B@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
MMS2_k127_4021339_3	263820.PTO1254	1.831e-48	184.0	COG0348@1|root,arCOG03697@2157|Archaea	2157|Archaea	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4021339_1	263820.PTO1253	1.495e-144	465.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10
MMS2_k127_4041588_0	273116.14324900	2.522e-30	126.0	COG3436@1|root,arCOG04792@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,SlyX,ZapB,zf-IS66
MMS2_k127_4041588_2	880072.Desac_2031	5.085e-17	85.0	COG3464@1|root,COG3464@2|Bacteria,1QW5Z@1224|Proteobacteria	1224|Proteobacteria	L	Transposase (IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
MMS2_k127_4041588_1	273116.14324802	5.12e-25	110.0	arCOG02754@1|root,arCOG02754@2157|Archaea	2157|Archaea	S	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_5
MMS2_k127_4041588_3	373994.Riv7116_4166	5.399e-13	77.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,1HNBR@1161|Nostocales	1117|Cyanobacteria	S	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Ras
MMS2_k127_4066070_0	273116.14325502	3.583e-152	497.0	COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,241II@183967|Thermoplasmata	183967|Thermoplasmata	P	YHS domain	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
MMS2_k127_4066070_6	634497.HAH_5037	1.183e-37	150.0	COG0596@1|root,arCOG01648@2157|Archaea,2Y784@28890|Euryarchaeota,240EW@183963|Halobacteria	183963|Halobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
MMS2_k127_4066070_1	351160.RCIX1093	4.058e-113	373.0	COG1073@1|root,arCOG01661@2157|Archaea,2XVIC@28890|Euryarchaeota,2NANZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Peptidase_S9
MMS2_k127_4066070_5	273116.14325461	4.446e-47	174.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota	28890|Euryarchaeota	S	Chromate resistance	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
MMS2_k127_4066070_2	196162.Noca_1430	2.01e-104	351.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4DNSX@85009|Propionibacteriales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
MMS2_k127_4066070_3	263820.PTO0184	1.748e-88	301.0	COG1878@1|root,arCOG02462@2157|Archaea,2XX0R@28890|Euryarchaeota	28890|Euryarchaeota	E	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
MMS2_k127_4066070_4	1462527.CCDM010000004_gene3401	5.708e-86	293.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4HCBR@91061|Bacilli,23JES@182709|Oceanobacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
MMS2_k127_4066070_8	460265.Mnod_1711	5.327e-19	95.0	COG2343@1|root,COG2343@2|Bacteria,1RHXD@1224|Proteobacteria,2UC5N@28211|Alphaproteobacteria,1JVJ3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF427)	MA20_09120	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
MMS2_k127_4066070_7	1380354.JIAN01000006_gene537	2.366e-27	114.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,4F2MU@85016|Cellulomonadaceae	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
MMS2_k127_4071636_3	1356854.N007_11560	4.416e-100	343.0	COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,4ISTJ@91061|Bacilli,279WD@186823|Alicyclobacillaceae	91061|Bacilli	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4071636_0	263820.PTO0772	4.472e-126	414.0	COG1473@1|root,arCOG01108@2157|Archaea,2XV81@28890|Euryarchaeota,241Y2@183967|Thermoplasmata	183967|Thermoplasmata	E	Peptidase family M20/M25/M40	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
MMS2_k127_4071636_1	273075.Ta0825	1.052e-120	395.0	COG1940@1|root,arCOG04280@2157|Archaea,2XUQY@28890|Euryarchaeota,24259@183967|Thermoplasmata	183967|Thermoplasmata	G	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
MMS2_k127_4071636_4	273075.Ta1083	3.961e-89	310.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,2421P@183967|Thermoplasmata	183967|Thermoplasmata	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
MMS2_k127_4071636_2	273116.14325352	1.631e-111	369.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,241JY@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS2_k127_4097776_12	273075.Ta1243m	7.599e-31	128.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,241U5@183967|Thermoplasmata	183967|Thermoplasmata	J	snoRNA binding domain, fibrillarin	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
MMS2_k127_4097776_1	273116.14324573	1.162e-186	595.0	COG0034@1|root,arCOG00093@2157|Archaea,2XSWJ@28890|Euryarchaeota,241K9@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
MMS2_k127_4097776_14	273116.14324575	2.36e-25	107.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y6AG@28890|Euryarchaeota,242DM@183967|Thermoplasmata	183967|Thermoplasmata	J	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
MMS2_k127_4097776_7	755178.Cyan10605_0930	7.947e-66	234.0	COG2897@1|root,COG2897@2|Bacteria,1G24M@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM Rhodanese-like domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
MMS2_k127_4097776_11	273116.14324583	6.448e-34	138.0	COG3413@1|root,arCOG02271@2157|Archaea,2Y7BN@28890|Euryarchaeota,242D2@183967|Thermoplasmata	183967|Thermoplasmata	K	HTH DNA binding domain	-	-	-	ko:K06930	-	-	-	-	ko00000	-	-	-	HTH_10
MMS2_k127_4097776_10	263820.PTO0407	5.579e-40	149.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,241RG@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
MMS2_k127_4097776_15	273116.14324629	5.034e-17	84.0	COG2051@1|root,arCOG04108@2157|Archaea,2Y6HD@28890|Euryarchaeota,241W8@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
MMS2_k127_4097776_6	273116.14324628	1.573e-83	284.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,241MC@183967|Thermoplasmata	183967|Thermoplasmata	J	translation initiation factor 2 subunit alpha	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
MMS2_k127_4097776_17	693661.Arcve_1030	1.345e-11	66.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,246GA@183980|Archaeoglobi	183980|Archaeoglobi	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
MMS2_k127_4097776_5	273075.Ta1201	3.676e-101	334.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,241Q6@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
MMS2_k127_4097776_0	439481.Aboo_0742	8.552e-190	612.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,3F2EU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
MMS2_k127_4097776_2	439481.Aboo_0743	6.768e-159	509.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,3F2HT@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
MMS2_k127_4097776_8	273116.14325519	4.204e-59	213.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota	28890|Euryarchaeota	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.100	ko:K18540	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
MMS2_k127_4097776_9	273116.14325517	3.757e-50	187.0	COG1877@1|root,arCOG01216@2157|Archaea,2Y7BA@28890|Euryarchaeota,242AK@183967|Thermoplasmata	183967|Thermoplasmata	G	Removes the phosphate from trehalose 6-phosphate	-	GO:0000287,GO:0003674,GO:0003824,GO:0004805,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
MMS2_k127_4097776_3	273116.14325516	1.749e-156	505.0	COG0380@1|root,arCOG02831@2157|Archaea,2XSTE@28890|Euryarchaeota,241YH@183967|Thermoplasmata	183967|Thermoplasmata	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
MMS2_k127_4097776_4	273075.Ta0952	7.046e-155	494.0	COG0039@1|root,arCOG00246@2157|Archaea,2XTQ0@28890|Euryarchaeota,2421M@183967|Thermoplasmata	183967|Thermoplasmata	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
MMS2_k127_4097776_16	273075.Ta0245m	5.52e-12	74.0	COG1605@1|root,arCOG07365@2157|Archaea,2Y5S5@28890|Euryarchaeota,242F1@183967|Thermoplasmata	183967|Thermoplasmata	E	Chorismate mutase type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
MMS2_k127_4097776_13	273116.14325613	2.925e-30	128.0	COG0287@1|root,arCOG00256@2157|Archaea,2Y4RC@28890|Euryarchaeota,242D4@183967|Thermoplasmata	183967|Thermoplasmata	C	prephenate dehydrogenase (NADP+) activity	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_4108385_1	273075.Ta0930	1.507e-74	254.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,241R5@183967|Thermoplasmata	183967|Thermoplasmata	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
MMS2_k127_4108385_2	273116.14325335	4.68e-54	197.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,241PF@183967|Thermoplasmata	183967|Thermoplasmata	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	HD,Trm56
MMS2_k127_4108385_0	1121335.Clst_1180	6.255e-106	355.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
MMS2_k127_4114878_12	273116.14325697	6.438e-10	64.0	COG2427@1|root,arCOG02113@2157|Archaea,2Y5ZD@28890|Euryarchaeota,242HP@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1641
MMS2_k127_4114878_3	273075.Ta0495	1.256e-105	353.0	COG0498@1|root,arCOG01434@2157|Archaea,2XVBI@28890|Euryarchaeota,2423Z@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_4114878_9	273116.14324396	7.349e-42	160.0	COG1670@1|root,arCOG00842@2157|Archaea,2Y7BJ@28890|Euryarchaeota,242C2@183967|Thermoplasmata	183967|Thermoplasmata	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
MMS2_k127_4114878_13	1117379.BABA_13847	0.0002579	52.0	COG1042@1|root,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,4HCHN@91061|Bacilli,1ZEZQ@1386|Bacillus	91061|Bacilli	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
MMS2_k127_4114878_5	263820.PTO1527	3.342e-94	321.0	COG0520@1|root,arCOG00065@2157|Archaea,2Y67Z@28890|Euryarchaeota,242FF@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-V	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS2_k127_4114878_0	273075.Ta0776	6.802e-212	664.0	COG0334@1|root,arCOG01352@2157|Archaea,2XU0F@28890|Euryarchaeota,241PE@183967|Thermoplasmata	183967|Thermoplasmata	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
MMS2_k127_4114878_10	1054217.TALC_01127	2.412e-39	151.0	COG0717@1|root,arCOG04048@2157|Archaea,2Y6CE@28890|Euryarchaeota,241VF@183967|Thermoplasmata	183967|Thermoplasmata	F	dUTPase	-	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
MMS2_k127_4114878_4	263820.PTO0131	6.249e-101	344.0	COG1457@1|root,arCOG03447@2157|Archaea,2Y0SR@28890|Euryarchaeota,24241@183967|Thermoplasmata	183967|Thermoplasmata	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
MMS2_k127_4114878_11	572546.Arcpr_0038	2.498e-13	76.0	COG1386@1|root,arCOG02613@2157|Archaea,2XZ7Q@28890|Euryarchaeota,2468R@183980|Archaeoglobi	183980|Archaeoglobi	K	segregation and condensation protein B	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
MMS2_k127_4114878_2	273116.14324840	2.455e-141	460.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,241JT@183967|Thermoplasmata	183967|Thermoplasmata	F	Phosphoribosylglycinamide synthetase, C domain	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
MMS2_k127_4114878_6	263820.PTO0949	5.123e-80	277.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,241RR@183967|Thermoplasmata	183967|Thermoplasmata	J	PFAM elongation factor Tu, domain 2 protein	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
MMS2_k127_4114878_8	263820.PTO0948	6.476e-51	192.0	COG0276@1|root,arCOG05373@2157|Archaea,2XTYB@28890|Euryarchaeota,24260@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
MMS2_k127_4114878_7	273075.Ta0310	6.295e-77	269.0	COG0407@1|root,arCOG03323@2157|Archaea,2XV21@28890|Euryarchaeota,2424C@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
MMS2_k127_4114878_1	263820.PTO1412	9.162e-193	610.0	COG0017@1|root,arCOG00407@2157|Archaea,2XTZJ@28890|Euryarchaeota,241ZH@183967|Thermoplasmata	183967|Thermoplasmata	J	asparaginyl-tRNA aminoacylation	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
MMS2_k127_4142058_5	185453.XP_006873582.1	1.247e-38	156.0	COG0179@1|root,KOG1535@2759|Eukaryota,38DXI@33154|Opisthokonta,3BCS8@33208|Metazoa,3CYTW@33213|Bilateria,486N8@7711|Chordata,493BZ@7742|Vertebrata,3JAYE@40674|Mammalia,34T44@311790|Afrotheria	33208|Metazoa	Q	Fumarylacetoacetate hydrolase domain-containing protein	FAHD2A	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
MMS2_k127_4142058_4	671065.MetMK1DRAFT_00001030	1.743e-47	188.0	COG0477@1|root,arCOG02682@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
MMS2_k127_4142058_1	1380394.JADL01000013_gene703	8.259e-72	254.0	COG0667@1|root,COG0667@2|Bacteria,1R5BH@1224|Proteobacteria,2TS0A@28211|Alphaproteobacteria,2JVHZ@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
MMS2_k127_4142058_3	760011.Spico_1043	1.532e-49	186.0	COG3246@1|root,COG3246@2|Bacteria	2|Bacteria	K	L-lysine catabolic process to acetate	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
MMS2_k127_4142058_6	768679.TTX_1407	3.745e-20	98.0	COG1335@1|root,arCOG01943@2157|Archaea,2XRQA@28889|Crenarchaeota	28889|Crenarchaeota	Q	Isochorismatase family	entB-like1	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS2_k127_4142058_0	930945.SiRe_2396	4.047e-84	289.0	COG0179@1|root,arCOG00235@2157|Archaea,2XQQH@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
MMS2_k127_4142058_2	411902.CLOBOL_02063	2.303e-55	206.0	COG1073@1|root,COG1073@2|Bacteria,1TRSD@1239|Firmicutes	1239|Firmicutes	S	Belongs to the UPF0255 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1100
MMS2_k127_4150852_1	273075.Ta0392	2.303e-151	487.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,241KY@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
MMS2_k127_4150852_4	273116.14325443	4.591e-54	194.0	COG0195@1|root,arCOG01760@2157|Archaea,2Y6CG@28890|Euryarchaeota,241TM@183967|Thermoplasmata	183967|Thermoplasmata	K	Participates in transcription termination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	-
MMS2_k127_4150852_2	1047013.AQSP01000037_gene1326	8.452e-108	356.0	COG1830@1|root,COG1830@2|Bacteria,2NPYC@2323|unclassified Bacteria	2|Bacteria	G	DeoC/LacD family aldolase	lsrF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.245,4.1.2.13	ko:K08321,ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
MMS2_k127_4150852_0	273075.Ta0481	8.443e-228	727.0	COG1028@1|root,arCOG01259@2157|Archaea	2157|Archaea	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS2_k127_4150852_3	273063.STK_24000	1.458e-85	297.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_4152821_0	273075.Ta0701	1.117e-18	96.0	COG0438@1|root,arCOG01411@2157|Archaea,2Y3ER@28890|Euryarchaeota,2426Y@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
MMS2_k127_4152821_1	673860.AciM339_0463	4.402e-14	78.0	COG3398@1|root,arCOG02611@2157|Archaea,2XWAQ@28890|Euryarchaeota,3F3BI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_24,HTH_5
MMS2_k127_4196793_1	1168289.AJKI01000015_gene2145	3.955e-59	208.0	COG0225@1|root,COG0225@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia,3XJZ5@558415|Marinilabiliaceae	976|Bacteroidetes	O	Peptide methionine sulfoxide reductase	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
MMS2_k127_4196793_2	290402.Cbei_1071	1.967e-36	147.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
MMS2_k127_4196793_3	263820.PTO0979	2.691e-36	141.0	COG1321@1|root,arCOG02100@2157|Archaea,2Y7B9@28890|Euryarchaeota,242AG@183967|Thermoplasmata	183967|Thermoplasmata	K	Iron dependent repressor, metal binding and dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
MMS2_k127_4196793_0	273075.Ta1156	1.934e-114	377.0	arCOG06008@1|root,arCOG06008@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4196793_4	1343739.PAP_08680	4.561e-20	100.0	arCOG11292@1|root,arCOG11292@2157|Archaea,2Y3FT@28890|Euryarchaeota,2443S@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4197751_1	1121085.AUCI01000002_gene3909	1.698e-18	89.0	COG0607@1|root,COG0607@2|Bacteria,1VES3@1239|Firmicutes,4HNRE@91061|Bacilli,1ZH5X@1386|Bacillus	91061|Bacilli	P	Sulfurtransferase	ytwF	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
MMS2_k127_4197751_0	273075.Ta0453m	9.995e-90	311.0	COG2379@1|root,arCOG04170@2157|Archaea,2XSTZ@28890|Euryarchaeota,2420W@183967|Thermoplasmata	183967|Thermoplasmata	G	MOFRL family	-	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
MMS2_k127_4197751_2	273116.14325201	1.069e-06	53.0	COG2519@1|root,arCOG00978@2157|Archaea,2XTV7@28890|Euryarchaeota,241UX@183967|Thermoplasmata	183967|Thermoplasmata	J	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
MMS2_k127_4198396_8	273116.14324313	1.044e-37	148.0	COG0508@1|root,arCOG01706@2157|Archaea,2XTSS@28890|Euryarchaeota,2421N@183967|Thermoplasmata	183967|Thermoplasmata	C	Biotin-lipoyl like	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS2_k127_4198396_0	273116.14324314	7.43e-156	497.0	COG0022@1|root,arCOG01052@2157|Archaea,2XT3K@28890|Euryarchaeota,2420C@183967|Thermoplasmata	183967|Thermoplasmata	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
MMS2_k127_4198396_1	273075.Ta1438	2.732e-126	413.0	COG1071@1|root,arCOG01054@2157|Archaea,2XUGH@28890|Euryarchaeota,24218@183967|Thermoplasmata	183967|Thermoplasmata	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
MMS2_k127_4198396_3	263820.PTO0550	2.087e-118	387.0	COG0320@1|root,arCOG00660@2157|Archaea,2XUQB@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
MMS2_k127_4198396_9	1121468.AUBR01000039_gene1924	1.226e-09	64.0	COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,247N5@186801|Clostridia,42F1N@68295|Thermoanaerobacterales	186801|Clostridia	O	Membrane-bound serine protease (ClpP class)	yqeZ	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
MMS2_k127_4198396_6	273116.14325648	5.848e-80	274.0	COG2086@1|root,arCOG00446@2157|Archaea,2XZ39@28890|Euryarchaeota,24263@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
MMS2_k127_4198396_5	273116.14325647	1.735e-87	299.0	COG2025@1|root,arCOG00447@2157|Archaea,2XT06@28890|Euryarchaeota,24204@183967|Thermoplasmata	183967|Thermoplasmata	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
MMS2_k127_4198396_4	1151117.AJLF01000001_gene1115	4.325e-110	377.0	COG1505@1|root,arCOG01647@2157|Archaea,2XTRD@28890|Euryarchaeota,243RD@183968|Thermococci	183968|Thermococci	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
MMS2_k127_4198396_2	985053.VMUT_0553	3.829e-122	403.0	COG0006@1|root,arCOG01000@2157|Archaea	2157|Archaea	E	Belongs to the peptidase M24B family	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
MMS2_k127_4198396_7	997346.HMPREF9374_2437	5.927e-43	168.0	COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,1TPG1@1239|Firmicutes,4HB2J@91061|Bacilli,27BAP@186824|Thermoactinomycetaceae	91061|Bacilli	C	4Fe-4S dicluster domain	ywjF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_4206968_7	273116.14324248	6.579e-08	54.0	COG3255@1|root,arCOG01843@2157|Archaea,2Y0F9@28890|Euryarchaeota,241WX@183967|Thermoplasmata	183967|Thermoplasmata	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS2_k127_4206968_0	273075.Ta0036m	0.0	1279.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,241KH@183967|Thermoplasmata	183967|Thermoplasmata	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
MMS2_k127_4206968_1	263820.PTO0620	1.252e-88	299.0	COG1100@1|root,arCOG01225@2157|Archaea,2XWN4@28890|Euryarchaeota,241NA@183967|Thermoplasmata	183967|Thermoplasmata	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
MMS2_k127_4206968_6	273075.Ta0012	1.128e-13	73.0	arCOG07353@1|root,arCOG07353@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4206968_2	930945.SiRe_0433	5.259e-80	281.0	COG3376@1|root,arCOG06023@2157|Archaea,2XRS9@28889|Crenarchaeota	28889|Crenarchaeota	P	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
MMS2_k127_4206968_8	65093.PCC7418_3086	3.74e-06	53.0	COG0681@1|root,COG0681@2|Bacteria,1GA6F@1117|Cyanobacteria	1117|Cyanobacteria	U	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
MMS2_k127_4206968_4	926569.ANT_02490	9.178e-54	194.0	293MU@1|root,2ZR3M@2|Bacteria	2|Bacteria	S	Nickel-containing superoxide dismutase	sodN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.15.1.1	ko:K00518	-	-	-	-	ko00000,ko01000	-	-	-	Sod_Ni
MMS2_k127_4206968_5	273075.Ta0014m	1.168e-50	188.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,24286@183967|Thermoplasmata	183967|Thermoplasmata	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
MMS2_k127_4206968_3	273116.14324343	6.643e-68	243.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,241NJ@183967|Thermoplasmata	183967|Thermoplasmata	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
MMS2_k127_4252855_8	273075.Ta0449	1.887e-09	62.0	arCOG07300@1|root,arCOG07300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4252855_1	273116.14325312	9e-157	519.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
MMS2_k127_4252855_3	589924.Ferp_0001	8.11e-24	114.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,245XC@183980|Archaeoglobi	183980|Archaeoglobi	L	Involved in regulation of DNA replication	-	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
MMS2_k127_4252855_0	263820.PTO1329	9.532e-265	825.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,241YS@183967|Thermoplasmata	183967|Thermoplasmata	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
MMS2_k127_4252855_5	981383.AEWH01000020_gene2507	1.337e-12	74.0	COG3011@1|root,COG3011@2|Bacteria,1VERZ@1239|Firmicutes,4HPNX@91061|Bacilli	91061|Bacilli	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
MMS2_k127_4252855_4	1128421.JAGA01000002_gene615	6.65e-23	106.0	COG0406@1|root,COG0406@2|Bacteria,2NRJK@2323|unclassified Bacteria	2|Bacteria	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
MMS2_k127_4256165_1	273057.SSO2130	2.95e-95	317.0	COG1013@1|root,arCOG01601@2157|Archaea,2XPVE@28889|Crenarchaeota	28889|Crenarchaeota	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
MMS2_k127_4256165_0	930945.SiRe_0339	6.288e-151	486.0	COG0674@1|root,arCOG01608@2157|Archaea,2XQ5N@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
MMS2_k127_4256165_2	399549.Msed_1201	2.731e-86	299.0	COG1144@1|root,arCOG01604@2157|Archaea,2XRKM@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (PorD-like)	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_21
MMS2_k127_4263312_1	700598.Niako_5160	5.497e-72	253.0	COG1319@1|root,COG1319@2|Bacteria,4NFT8@976|Bacteroidetes,1IV94@117747|Sphingobacteriia	976|Bacteroidetes	C	COGs COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs	-	-	1.17.1.4,1.2.5.3	ko:K03519,ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103,R11168	RC00143,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
MMS2_k127_4263312_2	263820.PTO1508	4.785e-37	150.0	COG1975@1|root,arCOG01929@2157|Archaea	2157|Archaea	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
MMS2_k127_4263312_3	575593.HMPREF0491_01916	2.242e-24	110.0	COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,24KIZ@186801|Clostridia,27PCC@186928|unclassified Lachnospiraceae	186801|Clostridia	OU	MobA-like NTP transferase domain	ygfJ	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
MMS2_k127_4263312_0	273116.14325314	9.836e-78	269.0	COG0614@1|root,arCOG04233@2157|Archaea,2Y7AK@28890|Euryarchaeota,24251@183967|Thermoplasmata	183967|Thermoplasmata	P	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
MMS2_k127_4277622_5	273116.14325318	6.507e-36	141.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,24220@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
MMS2_k127_4277622_7	273116.14324300	2.475e-29	121.0	COG0314@1|root,arCOG00534@2157|Archaea,2Y6DE@28890|Euryarchaeota,242D5@183967|Thermoplasmata	183967|Thermoplasmata	H	MoaE protein	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
MMS2_k127_4277622_3	273075.Ta0492	9.404e-43	164.0	COG0315@1|root,arCOG01530@2157|Archaea,2XWHQ@28890|Euryarchaeota,242AU@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
MMS2_k127_4277622_6	1382358.JHVN01000012_gene2135	4.921e-34	136.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4HH5V@91061|Bacilli,21VRA@150247|Anoxybacillus	91061|Bacilli	H	Probable molybdopterin binding domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
MMS2_k127_4277622_1	273075.Ta1149	3.648e-50	182.0	COG1599@1|root,arCOG01510@2157|Archaea,2Y7BB@28890|Euryarchaeota,242B4@183967|Thermoplasmata	183967|Thermoplasmata	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
MMS2_k127_4277622_0	273116.14325499	2.934e-210	670.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,241JJ@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
MMS2_k127_4277622_4	273075.Ta0932m	1.116e-37	152.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,241WS@183967|Thermoplasmata	183967|Thermoplasmata	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
MMS2_k127_4277622_2	263820.PTO1193	2.07e-43	164.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUCU@28890|Euryarchaeota,2421U@183967|Thermoplasmata	183967|Thermoplasmata	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4306266_2	273116.14324579	2.841e-61	219.0	arCOG07408@1|root,arCOG07408@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4306266_1	273116.14324585	9.262e-82	278.0	COG0723@1|root,arCOG01720@2157|Archaea	2157|Archaea	C	PFAM Rieske 2Fe-2S domain	soxL	-	-	-	-	-	-	-	-	-	-	-	Rieske
MMS2_k127_4306266_0	273075.Ta1228	6.842e-155	505.0	COG1290@1|root,arCOG01721@2157|Archaea,2XVE0@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1290 Cytochrome b subunit of the bc complex	petB2	-	-	ko:K15879	-	-	-	-	ko00000	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS2_k127_4306266_3	273075.Ta1235	6.154e-44	178.0	arCOG06974@1|root,arCOG06974@2157|Archaea,2Y4TI@28890|Euryarchaeota,242C1@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4314898_18	1056495.Calag_0558	5.725e-23	105.0	COG1335@1|root,arCOG01943@2157|Archaea,2XRXK@28889|Crenarchaeota	28889|Crenarchaeota	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
MMS2_k127_4314898_13	266265.Bxe_C0662	2.645e-40	155.0	COG3481@1|root,COG3481@2|Bacteria,1P23Y@1224|Proteobacteria	1224|Proteobacteria	S	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4314898_5	742821.HMPREF9464_00834	7.919e-137	454.0	COG1053@1|root,COG1053@2|Bacteria,1R0GR@1224|Proteobacteria,2WHU3@28216|Betaproteobacteria,4PRR9@995019|Sutterellaceae	28216|Betaproteobacteria	C	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
MMS2_k127_4314898_9	1174528.JH992898_gene3564	4.9e-76	267.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1G0MX@1117|Cyanobacteria,1JIE9@1189|Stigonemataceae	1117|Cyanobacteria	FL	Metal binding domain of Ada	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
MMS2_k127_4314898_8	521045.Kole_1432	1.487e-87	300.0	COG0549@1|root,COG0549@2|Bacteria,2GCB0@200918|Thermotogae	200918|Thermotogae	E	Belongs to the carbamate kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
MMS2_k127_4314898_16	263820.PTO0494	2.258e-26	110.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y1B9@28890|Euryarchaeota,242DV@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
MMS2_k127_4314898_22	273075.Ta0001	2.723e-08	62.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y7CD@28890|Euryarchaeota,242HT@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
MMS2_k127_4314898_7	273116.14324263	1.379e-87	301.0	COG1527@1|root,arCOG02459@2157|Archaea,2Y67I@28890|Euryarchaeota,24275@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
MMS2_k127_4314898_19	273075.Ta0003	8.859e-22	99.0	COG1436@1|root,arCOG04102@2157|Archaea,2Y5Y7@28890|Euryarchaeota,242ET@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
MMS2_k127_4314898_0	273116.14324265	9.319e-253	791.0	COG1155@1|root,arCOG00868@2157|Archaea,2XT8I@28890|Euryarchaeota,241M5@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn,Intein_splicing
MMS2_k127_4314898_1	263820.PTO0489	5.815e-211	663.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,241K0@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
MMS2_k127_4314898_11	273116.14324267	4.923e-66	231.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,241TN@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
MMS2_k127_4314898_3	273116.14324269	4.832e-169	552.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,241UP@183967|Thermoplasmata	183967|Thermoplasmata	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
MMS2_k127_4314898_23	44454.NF84_14850	0.0001872	48.0	COG1585@1|root,COG1585@2|Bacteria,2IHZU@201174|Actinobacteria,2397Z@1762|Mycobacteriaceae	201174|Actinobacteria	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
MMS2_k127_4314898_12	273116.14324711	3.974e-46	180.0	COG0436@1|root,arCOG04334@2157|Archaea,2Y7JJ@28890|Euryarchaeota,242DD@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
MMS2_k127_4314898_6	387631.Asulf_01198	2.697e-105	349.0	COG1250@1|root,arCOG00250@2157|Archaea,2XTMV@28890|Euryarchaeota	28890|Euryarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
MMS2_k127_4314898_21	273116.14324599	2.261e-08	63.0	arCOG07404@1|root,arCOG07404@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4314898_17	32057.KB217478_gene2726	4.934e-25	117.0	COG0673@1|root,COG0673@2|Bacteria,1G18V@1117|Cyanobacteria,1HN0A@1161|Nostocales	1117|Cyanobacteria	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	1.1.1.335,1.1.99.28	ko:K00118,ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
MMS2_k127_4314898_4	273116.14324404	3.439e-141	459.0	COG1171@1|root,arCOG01431@2157|Archaea,2XT4W@28890|Euryarchaeota,2420P@183967|Thermoplasmata	183967|Thermoplasmata	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_4,PALP
MMS2_k127_4314898_20	273116.14324234	2.486e-16	81.0	COG1254@1|root,arCOG01674@2157|Archaea,2Y7C5@28890|Euryarchaeota,242G3@183967|Thermoplasmata	183967|Thermoplasmata	C	acylphosphatase activity	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
MMS2_k127_4314898_2	263820.PTO0744	1.089e-181	576.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,241JZ@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
MMS2_k127_4314898_14	273075.Ta0728	6.213e-35	141.0	arCOG07179@1|root,arCOG07179@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4314898_10	273075.Ta1403	5.584e-74	278.0	arCOG03675@1|root,arCOG03675@2157|Archaea,2Y2KX@28890|Euryarchaeota,2421C@183967|Thermoplasmata	183967|Thermoplasmata	E	Thermopsin	-	-	3.4.23.42	ko:K01385	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Thermopsin
MMS2_k127_4314898_15	273075.Ta0129	8.609e-30	138.0	COG4945@1|root,arCOG03771@2157|Archaea	2157|Archaea	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glucodextran_C,Glyco_hydro_57,PEGA
MMS2_k127_4342352_2	273063.STK_16040	4.96e-07	55.0	arCOG03860@1|root,arCOG03860@2157|Archaea	2157|Archaea	-	-	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt,HTH_20
MMS2_k127_4342352_0	634498.mru_0779	2.42e-15	82.0	arCOG01782@1|root,arCOG01782@2157|Archaea	2157|Archaea	H	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
MMS2_k127_4342352_3	1198449.ACAM_0365	1.26e-06	54.0	arCOG03403@1|root,arCOG03403@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
MMS2_k127_4342352_1	118173.KB235914_gene3188	8.476e-10	68.0	COG0457@1|root,COG0457@2|Bacteria,1GE1S@1117|Cyanobacteria	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_2,TPR_8
MMS2_k127_4347177_0	1347087.CBYO010000004_gene400	2.091e-25	109.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli	91061|Bacilli	F	amidohydrolase	hipO3	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
MMS2_k127_4363344_3	1449342.JQMR01000001_gene852	9.922e-39	159.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,27F99@186828|Carnobacteriaceae	91061|Bacilli	M	Glycosyl transferase 4-like domain	pimB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
MMS2_k127_4363344_2	273116.14325055	8.218e-75	261.0	COG2423@1|root,arCOG01035@2157|Archaea,2XT4P@28890|Euryarchaeota,24266@183967|Thermoplasmata	183967|Thermoplasmata	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
MMS2_k127_4363344_5	263820.PTO1001	4.908e-25	107.0	arCOG05376@1|root,arCOG05376@2157|Archaea,2Y4VU@28890|Euryarchaeota,242E3@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4363344_0	273075.Ta0356	1.028e-144	466.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,241J4@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
MMS2_k127_4363344_4	273116.14324374	1.32e-37	148.0	COG5615@1|root,arCOG05392@2157|Archaea,2Y453@28890|Euryarchaeota,2429S@183967|Thermoplasmata	183967|Thermoplasmata	S	protein, homolog of Cu resistance protein CopC	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4363344_1	263820.PTO0854	4.31e-76	259.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,241NY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
MMS2_k127_4363344_6	263820.PTO0853	3.772e-13	68.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,241NK@183967|Thermoplasmata	183967|Thermoplasmata	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
MMS2_k127_4380680_9	273075.Ta1436	4.394e-71	247.0	COG0508@1|root,arCOG01706@2157|Archaea,2XTSS@28890|Euryarchaeota,2421N@183967|Thermoplasmata	183967|Thermoplasmata	C	Biotin-lipoyl like	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
MMS2_k127_4380680_2	273075.Ta1435	1.594e-189	600.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,2423A@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
MMS2_k127_4380680_11	263820.PTO0545	6.575e-56	203.0	COG0321@1|root,arCOG01942@2157|Archaea	2157|Archaea	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
MMS2_k127_4380680_12	273075.Ta1434	1.018e-46	174.0	COG2096@1|root,arCOG00489@2157|Archaea,2XTKK@28890|Euryarchaeota,2425V@183967|Thermoplasmata	183967|Thermoplasmata	H	Cobalamin adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Cob_adeno_trans
MMS2_k127_4380680_8	263820.PTO0370	4.862e-72	250.0	COG0013@1|root,arCOG01254@2157|Archaea,2XTZC@28890|Euryarchaeota,241V1@183967|Thermoplasmata	183967|Thermoplasmata	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
MMS2_k127_4380680_7	273075.Ta0125	2.873e-84	284.0	COG0526@1|root,arCOG01218@2157|Archaea,2XY63@28890|Euryarchaeota,2423H@183967|Thermoplasmata	183967|Thermoplasmata	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
MMS2_k127_4380680_14	1121943.KB899991_gene2553	1.509e-07	57.0	COG3255@1|root,COG3255@2|Bacteria,1N206@1224|Proteobacteria,1S8RI@1236|Gammaproteobacteria,1XKS6@135619|Oceanospirillales	135619|Oceanospirillales	I	sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
MMS2_k127_4380680_0	273075.Ta0291	7.987e-253	796.0	COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,24225@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
MMS2_k127_4380680_4	273057.SSO2737	8.781e-140	456.0	COG0624@1|root,arCOG01110@2157|Archaea	2157|Archaea	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
MMS2_k127_4380680_6	273075.Ta0335	8.586e-98	337.0	COG1208@1|root,arCOG00663@2157|Archaea,2XUID@28890|Euryarchaeota,24252@183967|Thermoplasmata	183967|Thermoplasmata	M	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
MMS2_k127_4380680_10	263820.PTO0246	1.729e-67	244.0	COG1473@1|root,arCOG01108@2157|Archaea,2XUUS@28890|Euryarchaeota,2423B@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer
MMS2_k127_4380680_1	273075.Ta0816	8.541e-214	677.0	COG0028@1|root,arCOG01999@2157|Archaea,2XWG6@28890|Euryarchaeota,2424J@183967|Thermoplasmata	183967|Thermoplasmata	C	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	1.2.5.1	ko:K00156	ko00620,map00620	-	R03145	RC00860	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
MMS2_k127_4380680_15	1463920.JOGB01000054_gene4523	1.378e-05	50.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
MMS2_k127_4380680_5	273068.TTE2012	1.914e-126	423.0	COG2060@1|root,COG2060@2|Bacteria,1TPDF@1239|Firmicutes,24868@186801|Clostridia,42FFE@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
MMS2_k127_4380680_3	1295642.H839_00410	2.18e-167	550.0	COG2216@1|root,COG2216@2|Bacteria,1TPV5@1239|Firmicutes,4HASV@91061|Bacilli,1WEY6@129337|Geobacillus	91061|Bacilli	P	of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
MMS2_k127_4380680_13	482234.SCAZ3_01295	1.412e-13	80.0	COG2156@1|root,COG2156@2|Bacteria,1V4GE@1239|Firmicutes,4HHHD@91061|Bacilli	91061|Bacilli	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
MMS2_k127_4394856_8	273116.14324965	1.524e-48	176.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,241TA@183967|Thermoplasmata	183967|Thermoplasmata	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
MMS2_k127_4394856_4	273116.14324964	1.45e-75	257.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota,241QZ@183967|Thermoplasmata	183967|Thermoplasmata	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
MMS2_k127_4394856_2	273116.14324963	6.445e-90	307.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,241SG@183967|Thermoplasmata	183967|Thermoplasmata	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
MMS2_k127_4394856_5	263820.PTO0182	2.658e-65	235.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,241QE@183967|Thermoplasmata	183967|Thermoplasmata	H	UbiA prenyltransferase family	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
MMS2_k127_4394856_3	263820.PTO0183	7.44e-84	286.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,241NR@183967|Thermoplasmata	183967|Thermoplasmata	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
MMS2_k127_4394856_10	273075.Ta1044m	2.131e-09	61.0	COG1828@1|root,arCOG04462@2157|Archaea,2Y79Q@28890|Euryarchaeota,241WD@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
MMS2_k127_4394856_1	273075.Ta1066	8.68e-259	818.0	COG0046@1|root,arCOG00641@2157|Archaea,2XU49@28890|Euryarchaeota,241M2@183967|Thermoplasmata	183967|Thermoplasmata	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
MMS2_k127_4394856_0	273075.Ta0838	0.0	1062.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241ID@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS2_k127_4394856_7	273116.14324776	6.869e-53	191.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,241SD@183967|Thermoplasmata	183967|Thermoplasmata	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
MMS2_k127_4394856_6	273075.Ta1032	4.96e-61	217.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,241PV@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
MMS2_k127_4394856_9	263820.PTO1221	2.673e-27	113.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,241PM@183967|Thermoplasmata	183967|Thermoplasmata	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
MMS2_k127_442271_3	273116.14324571	1.515e-102	342.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,241NC@183967|Thermoplasmata	183967|Thermoplasmata	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	PUA,TruB_C_2,TruB_N
MMS2_k127_442271_20	439481.Aboo_1495	2.021e-44	167.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,3F3AN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
MMS2_k127_442271_16	273116.14324569	2.236e-52	193.0	COG1422@1|root,arCOG02673@2157|Archaea,2XZDK@28890|Euryarchaeota,241UY@183967|Thermoplasmata	183967|Thermoplasmata	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
MMS2_k127_442271_8	263820.PTO0664	7.796e-69	237.0	COG2019@1|root,arCOG01039@2157|Archaea,2XVK7@28890|Euryarchaeota,2426T@183967|Thermoplasmata	183967|Thermoplasmata	F	adenylate kinase activity	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
MMS2_k127_442271_0	263820.PTO0663	2.937e-277	862.0	COG5253@1|root,arCOG04169@2157|Archaea,2XT9A@28890|Euryarchaeota,241IV@183967|Thermoplasmata	183967|Thermoplasmata	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
MMS2_k127_442271_15	273116.14324566	9.95e-55	194.0	COG0200@1|root,arCOG00779@2157|Archaea,2Y6A4@28890|Euryarchaeota,241UA@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 23S rRNA	rpl15	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
MMS2_k127_442271_28	671065.MetMK1DRAFT_00021650	1.069e-11	72.0	COG1841@1|root,arCOG04086@2157|Archaea	2157|Archaea	J	Ribosomal protein L30	rpl30	GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
MMS2_k127_442271_2	263820.PTO0660	4.72e-112	364.0	COG0098@1|root,arCOG04087@2157|Archaea,2XUQU@28890|Euryarchaeota,241N3@183967|Thermoplasmata	183967|Thermoplasmata	J	With S4 and S12 plays an important role in translational accuracy	rps5	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
MMS2_k127_442271_22	263820.PTO0659	2.158e-41	159.0	COG0256@1|root,arCOG04088@2157|Archaea,2XTWT@28890|Euryarchaeota,241TI@183967|Thermoplasmata	183967|Thermoplasmata	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
MMS2_k127_442271_19	263820.PTO0658	2.646e-49	180.0	COG2147@1|root,arCOG04089@2157|Archaea,2XWU1@28890|Euryarchaeota,241SR@183967|Thermoplasmata	183967|Thermoplasmata	J	binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
MMS2_k127_442271_18	263820.PTO0657	1.475e-49	179.0	COG1717@1|root,arCOG00781@2157|Archaea,2XSZ4@28890|Euryarchaeota,241T4@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl32e	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
MMS2_k127_442271_13	263820.PTO0656	1.662e-58	207.0	COG0097@1|root,arCOG04090@2157|Archaea,2XTIS@28890|Euryarchaeota,241S0@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
MMS2_k127_442271_14	263820.PTO0655	1.768e-55	196.0	COG0096@1|root,arCOG04091@2157|Archaea,2XWMU@28890|Euryarchaeota,241Q9@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
MMS2_k127_442271_25	673860.AciM339_1112	3.015e-21	93.0	COG0199@1|root,arCOG00782@2157|Archaea,2Y68V@28890|Euryarchaeota,3F2V3@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	ribosomal protein S14	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
MMS2_k127_442271_10	263820.PTO0653	2.343e-65	230.0	COG0094@1|root,arCOG04092@2157|Archaea,2XTRN@28890|Euryarchaeota,241QF@183967|Thermoplasmata	183967|Thermoplasmata	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
MMS2_k127_442271_7	273116.14324556	8.954e-70	244.0	COG1471@1|root,arCOG04093@2157|Archaea,2XT03@28890|Euryarchaeota,241SU@183967|Thermoplasmata	183967|Thermoplasmata	J	rRNA binding	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
MMS2_k127_442271_24	273075.Ta1259a	9.755e-32	132.0	COG0198@1|root,arCOG04094@2157|Archaea,2XXV4@28890|Euryarchaeota,241WI@183967|Thermoplasmata	183967|Thermoplasmata	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L26
MMS2_k127_442271_9	273075.Ta1261	4.257e-67	229.0	COG0093@1|root,arCOG04095@2157|Archaea,2XWM6@28890|Euryarchaeota,241QD@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
MMS2_k127_442271_23	273116.14324553	7.544e-35	139.0	COG0186@1|root,arCOG04096@2157|Archaea,2XYPE@28890|Euryarchaeota,241UC@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rps17	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
MMS2_k127_442271_29	7897.ENSLACP00000009732	0.0003245	49.0	KOG4046@1|root,KOG4046@2759|Eukaryota,38FJA@33154|Opisthokonta,3BDX0@33208|Metazoa,3CZFR@33213|Bilateria,48AN2@7711|Chordata,48UY8@7742|Vertebrata	33208|Metazoa	A	ribonuclease P RNA binding	POP4	GO:0000172,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005655,GO:0005730,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019843,GO:0022613,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042134,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03538	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	UPF0086
MMS2_k127_442271_21	263820.PTO0648	1.143e-43	160.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,241TJ@183967|Thermoplasmata	183967|Thermoplasmata	J	posttranscriptional regulation of gene expression	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
MMS2_k127_442271_26	263820.PTO0647	2.67e-14	77.0	COG0255@1|root,arCOG00785@2157|Archaea,2Y6IK@28890|Euryarchaeota,241WF@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uL29 family	rpl29	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
MMS2_k127_442271_5	273075.Ta1265	5.043e-86	295.0	COG0092@1|root,arCOG04097@2157|Archaea,2XTHR@28890|Euryarchaeota,241P0@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds the lower part of the 30S subunit head	rps3	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
MMS2_k127_442271_17	263820.PTO0645	2.546e-51	187.0	COG0091@1|root,arCOG04098@2157|Archaea,2XWGN@28890|Euryarchaeota,241UI@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl22	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
MMS2_k127_442271_11	273116.14324547	6.586e-64	222.0	COG0185@1|root,arCOG04099@2157|Archaea,2XWI9@28890|Euryarchaeota,241QN@183967|Thermoplasmata	183967|Thermoplasmata	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rps19p	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
MMS2_k127_442271_4	273075.Ta1268	1.828e-97	323.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,241PZ@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2_C
MMS2_k127_442271_27	420247.Msm_0760	1.209e-13	74.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,23PS1@183925|Methanobacteria	183925|Methanobacteria	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
MMS2_k127_442271_6	263820.PTO0641	1.146e-85	291.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,241PY@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
MMS2_k127_442271_1	263820.PTO0640	1.993e-140	452.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,241MA@183967|Thermoplasmata	183967|Thermoplasmata	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
MMS2_k127_442271_12	118161.KB235922_gene296	5.64e-63	240.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,3VJQ2@52604|Pleurocapsales	1117|Cyanobacteria	O	PFAM Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_1,TPR_11,TPR_14,TPR_16,TPR_2,TPR_6,TPR_8
MMS2_k127_4423969_1	273116.14324306	7.271e-41	156.0	COG1576@1|root,arCOG00502@2157|Archaea,2XZ8Z@28890|Euryarchaeota,241TX@183967|Thermoplasmata	183967|Thermoplasmata	J	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
MMS2_k127_4423969_4	604354.TSIB_1586	0.0003683	45.0	COG1011@1|root,arCOG02291@2157|Archaea,2Y2J0@28890|Euryarchaeota,2430U@183968|Thermococci	183968|Thermococci	S	HAD-hyrolase-like	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
MMS2_k127_4423969_3	263820.PTO0537	1.111e-07	55.0	COG2104@1|root,arCOG00535@2157|Archaea,2Y5Q5@28890|Euryarchaeota,242FE@183967|Thermoplasmata	183967|Thermoplasmata	H	ThiS family	-	-	-	-	-	-	-	-	-	-	-	-	ThiS
MMS2_k127_4423969_0	263820.PTO0535	2.124e-106	359.0	COG1746@1|root,arCOG04249@2157|Archaea,2XT5J@28890|Euryarchaeota,241NH@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
MMS2_k127_4423969_2	273075.Ta1447	5.532e-31	125.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,241VM@183967|Thermoplasmata	183967|Thermoplasmata	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
MMS2_k127_4444626_0	263820.PTO1165	8.236e-57	205.0	COG1215@1|root,arCOG01389@2157|Archaea,2Y7AD@28890|Euryarchaeota,24212@183967|Thermoplasmata	183967|Thermoplasmata	M	Glycosyl transferase family 21	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_21
MMS2_k127_4444626_3	263820.PTO1164	4.591e-19	89.0	COG2092@1|root,arCOG01988@2157|Archaea,2Y7BM@28890|Euryarchaeota,242D1@183967|Thermoplasmata	183967|Thermoplasmata	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
MMS2_k127_4444626_4	263820.PTO1163	1.396e-18	85.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y77Z@28890|Euryarchaeota,242HV@183967|Thermoplasmata	183967|Thermoplasmata	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
MMS2_k127_4444626_1	273116.14324832	1.176e-46	175.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,241UR@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4444626_5	644281.MFS40622_0226	2.874e-05	58.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,23R7V@183939|Methanococci	183939|Methanococci	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
MMS2_k127_4444626_2	273116.14324821	7.657e-29	118.0	COG0663@1|root,arCOG01849@2157|Archaea,2XXXX@28890|Euryarchaeota,2428B@183967|Thermoplasmata	183967|Thermoplasmata	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
MMS2_k127_4480488_0	273116.14325571	5.019e-138	450.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,241QX@183967|Thermoplasmata	183967|Thermoplasmata	I	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
MMS2_k127_4480488_2	930945.SiRe_2046	6.36e-49	182.0	COG2345@1|root,arCOG01692@2157|Archaea	2157|Archaea	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
MMS2_k127_4480488_1	263820.PTO0815	2.059e-136	443.0	arCOG00144@1|root,arCOG00144@2157|Archaea,2Y6AX@28890|Euryarchaeota,242CM@183967|Thermoplasmata	183967|Thermoplasmata	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4506904_5	643473.KB235930_gene1384	0.0006363	46.0	COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria,1HID8@1161|Nostocales	1117|Cyanobacteria	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
MMS2_k127_4506904_2	273075.Ta1106	3.435e-43	163.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,241VB@183967|Thermoplasmata	183967|Thermoplasmata	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	ACT
MMS2_k127_4506904_0	273116.14324671	5.504e-163	518.0	COG0468@1|root,arCOG00415@2157|Archaea,2XT80@28890|Euryarchaeota,241KB@183967|Thermoplasmata	183967|Thermoplasmata	L	Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules	radA	-	-	ko:K04483	-	-	-	-	ko00000,ko03400	-	-	-	HHH_5,Rad51
MMS2_k127_4506904_1	273116.14324672	1.118e-130	425.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,241JM@183967|Thermoplasmata	183967|Thermoplasmata	G	4-hydroxy-tetrahydrodipicolinate reductase	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
MMS2_k127_4506904_4	591019.Shell_0840	1.045e-28	128.0	COG0451@1|root,arCOG01369@2157|Archaea,2XQCJ@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,5.1.3.2	ko:K01784,ko:K08678	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01384,R02984	RC00289,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
MMS2_k127_4506904_3	1298860.AUEM01000002_gene539	9.087e-43	158.0	COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4FQZI@85023|Microbacteriaceae	201174|Actinobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
MMS2_k127_4512574_7	555079.Toce_0357	1.08e-12	71.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,42F1M@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
MMS2_k127_4512574_6	1111479.AXAR01000007_gene895	2.816e-39	157.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli,279AY@186823|Alicyclobacillaceae	91061|Bacilli	P	TIGRFAM phosphate ABC transporter, inner membrane subunit PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS2_k127_4512574_4	1356854.N007_20575	5.829e-64	231.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,4HC9H@91061|Bacilli,279VP@186823|Alicyclobacillaceae	91061|Bacilli	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
MMS2_k127_4512574_3	243159.AFE_1939	4.882e-71	254.0	COG0226@1|root,COG0226@2|Bacteria,1R9S4@1224|Proteobacteria,1SJT9@1236|Gammaproteobacteria,2NCGA@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
MMS2_k127_4512574_5	768679.TTX_0809	1.083e-56	211.0	COG1748@1|root,arCOG00243@2157|Archaea,2XQJJ@28889|Crenarchaeota	28889|Crenarchaeota	C	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP,Semialdhyde_dh,UDPG_MGDP_dh_N
MMS2_k127_4512574_0	273075.Ta1478	3.834e-223	703.0	COG2759@1|root,arCOG04541@2157|Archaea,2XUXB@28890|Euryarchaeota,241K6@183967|Thermoplasmata	183967|Thermoplasmata	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
MMS2_k127_4512574_1	105425.BBPL01000013_gene1768	7.92e-89	302.0	COG0491@1|root,COG0491@2|Bacteria,2IA0M@201174|Actinobacteria,2NEJR@228398|Streptacidiphilus	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_4512574_2	1437425.CSEC_2409	4.483e-72	249.0	COG2818@1|root,COG2818@2|Bacteria,2JG0U@204428|Chlamydiae	204428|Chlamydiae	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
MMS2_k127_4512574_8	1382356.JQMP01000003_gene1338	0.0001824	54.0	COG5650@1|root,COG5650@2|Bacteria,2GB8F@200795|Chloroflexi,27Y1V@189775|Thermomicrobia	189775|Thermomicrobia	S	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4521533_0	273075.Ta1469	2.233e-161	518.0	arCOG00138@1|root,arCOG00138@2157|Archaea	2157|Archaea	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
MMS2_k127_4521533_1	273116.14324900	0.0005298	45.0	COG3436@1|root,arCOG04792@2157|Archaea	2157|Archaea	L	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,SlyX,ZapB,zf-IS66
MMS2_k127_4539760_1	591159.ACEZ01000152_gene1727	2.84e-07	61.0	COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Polysacc_deac_1
MMS2_k127_4539760_0	186497.PF0661	7.233e-19	96.0	COG1378@1|root,arCOG02037@2157|Archaea,2XXJ9@28890|Euryarchaeota,2449I@183968|Thermococci	183968|Thermococci	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
MMS2_k127_4539760_2	1229909.NSED_03115	3.775e-07	54.0	arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
MMS2_k127_4543714_2	263820.PTO0603	4.302e-88	300.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,241MK@183967|Thermoplasmata	183967|Thermoplasmata	J	DALR anticodon binding domain	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	DALR_1,tRNA-synt_1d
MMS2_k127_4543714_1	273116.14325583	3.88e-114	404.0	arCOG07368@1|root,arCOG07368@2157|Archaea,2XZV6@28890|Euryarchaeota,242AS@183967|Thermoplasmata	183967|Thermoplasmata	S	CARDB	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
MMS2_k127_4543714_3	263820.PTO0711	6.95e-59	218.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,242BM@183967|Thermoplasmata	183967|Thermoplasmata	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
MMS2_k127_4543714_0	529709.PYCH_04230	3.793e-131	433.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,24310@183968|Thermococci	183968|Thermococci	J	tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs	rtcB	GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,LAGLIDADG_3,RtcB
MMS2_k127_4543714_4	263820.PTO0699	0.0001259	47.0	arCOG10671@1|root,arCOG10671@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4570025_0	273116.14325431	7.037e-142	463.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,241X1@183967|Thermoplasmata	183967|Thermoplasmata	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	1.1.1.34,1.1.1.88	ko:K00021,ko:K00054	ko00900,ko01100,ko01110,ko01130,ko04152,ko04976,map00900,map01100,map01110,map01130,map04152,map04976	M00095	R02081,R02082	RC00004,RC00644	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG-CoA_red
MMS2_k127_4570025_2	263820.PTO1142	4.166e-28	124.0	COG0457@1|root,arCOG03045@2157|Archaea,2Y3R1@28890|Euryarchaeota,2429D@183967|Thermoplasmata	183967|Thermoplasmata	S	tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4570025_1	263820.PTO0221	3.465e-31	127.0	COG3612@1|root,arCOG04418@2157|Archaea,2Y7B7@28890|Euryarchaeota,242A8@183967|Thermoplasmata	183967|Thermoplasmata	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
MMS2_k127_4570025_3	263820.PTO1248	1.227e-12	68.0	COG1225@1|root,arCOG00310@2157|Archaea,2XXB2@28890|Euryarchaeota,2427J@183967|Thermoplasmata	183967|Thermoplasmata	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
MMS2_k127_4572363_6	273116.14325444	5.934e-17	85.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,241KY@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
MMS2_k127_4572363_1	273075.Ta0391	0.0	1407.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,241IQ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
MMS2_k127_4572363_0	273075.Ta0390	0.0	1922.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,241IZ@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
MMS2_k127_4572363_5	273075.Ta0389	1.056e-25	109.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y6HJ@28890|Euryarchaeota,241W1@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
MMS2_k127_4572363_2	273075.Ta1212	1.102e-159	508.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,241IN@183967|Thermoplasmata	183967|Thermoplasmata	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K03239,ko:K08963	ko00270,ko01100,ko03013,map00270,map01100,map03013	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000,ko03012	-	-	-	IF-2B
MMS2_k127_4572363_3	1131266.ARWQ01000001_gene1124	8.68e-141	456.0	COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
MMS2_k127_4572363_4	273075.Ta0953m	5.455e-49	182.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	-	-	-	-	-	-	-	-	-	-	-	-	GvpD
MMS2_k127_4574289_6	273075.Ta1288	6.953e-54	190.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,241MX@183967|Thermoplasmata	183967|Thermoplasmata	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
MMS2_k127_4574289_5	273116.14324519	1.428e-65	234.0	COG1831@1|root,arCOG00893@2157|Archaea,2XTX7@28890|Euryarchaeota,241VE@183967|Thermoplasmata	183967|Thermoplasmata	S	TatD related DNase	-	-	-	ko:K07049	-	-	-	-	ko00000	-	-	-	TatD_DNase
MMS2_k127_4574289_10	263820.PTO0266	3.992e-20	98.0	COG1711@1|root,arCOG00551@2157|Archaea,2Y7CG@28890|Euryarchaeota,242DH@183967|Thermoplasmata	183967|Thermoplasmata	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
MMS2_k127_4574289_11	273075.Ta1047a	9.667e-16	78.0	arCOG05330@1|root,arCOG05330@2157|Archaea,2Y24Y@28890|Euryarchaeota,242GS@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4574289_3	673860.AciM339_0524	3.657e-90	304.0	COG0463@1|root,arCOG01385@2157|Archaea,2XUEP@28890|Euryarchaeota,3F30S@33867|unclassified Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase family 2	aglI	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
MMS2_k127_4574289_9	929556.Solca_1196	3.431e-32	133.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_4574289_0	273116.14325002	1.85e-271	844.0	COG1884@1|root,arCOG04232@2157|Archaea,2XU3F@28890|Euryarchaeota,24230@183967|Thermoplasmata	183967|Thermoplasmata	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
MMS2_k127_4574289_7	1459636.NTE_01111	1.014e-45	169.0	COG2185@1|root,arCOG01710@2157|Archaea,41SJN@651137|Thaumarchaeota	651137|Thaumarchaeota	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
MMS2_k127_4574289_4	273116.14325004	1.098e-88	302.0	COG1703@1|root,arCOG01226@2157|Archaea,2XUHG@28890|Euryarchaeota,2421X@183967|Thermoplasmata	183967|Thermoplasmata	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
MMS2_k127_4574289_8	263820.PTO0419	9.421e-36	141.0	COG1765@1|root,arCOG03685@2157|Archaea,2Y05H@28890|Euryarchaeota,242AT@183967|Thermoplasmata	183967|Thermoplasmata	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
MMS2_k127_4574289_1	263820.PTO0466	1.078e-194	618.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,241IT@183967|Thermoplasmata	183967|Thermoplasmata	J	lysyl-tRNA aminoacylation	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
MMS2_k127_4574289_2	273075.Ta1164	3.272e-90	301.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,2421I@183967|Thermoplasmata	183967|Thermoplasmata	F	nucleoside metabolic process	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
MMS2_k127_4574289_12	273116.14325479	3.817e-13	71.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242AC@183967|Thermoplasmata	183967|Thermoplasmata	F	HIT domain	-	-	3.6.1.17	ko:K01518,ko:K02503	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT
MMS2_k127_4575651_3	985053.VMUT_0539	2.036e-97	328.0	COG1995@1|root,arCOG08631@2157|Archaea	2157|Archaea	H	COG1995 Pyridoxal phosphate biosynthesis protein	-	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
MMS2_k127_4575651_6	1121382.JQKG01000010_gene4607	8.375e-16	83.0	COG0454@1|root,COG0456@2|Bacteria,1WMTD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_9
MMS2_k127_4575651_2	273116.14325565	5.232e-105	355.0	COG0513@1|root,arCOG00558@2157|Archaea,2XUS4@28890|Euryarchaeota,241NG@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
MMS2_k127_4575651_5	263820.PTO1116	3.729e-62	224.0	COG1052@1|root,arCOG01755@2157|Archaea,2XZQ9@28890|Euryarchaeota,24272@183967|Thermoplasmata	183967|Thermoplasmata	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
MMS2_k127_4575651_4	374847.Kcr_0710	1.505e-73	267.0	COG1078@1|root,arCOG04430@2157|Archaea	2157|Archaea	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
MMS2_k127_4575651_1	263820.PTO0587	2.565e-116	383.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,241K8@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Rep_fac_C
MMS2_k127_4575651_0	273116.14325756	2.27e-138	456.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,24250@183967|Thermoplasmata	183967|Thermoplasmata	L	helicase superfamily c-terminal domain	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	Helicase_C,ResIII
MMS2_k127_4633858_0	273116.14325177	0.0	1055.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,241JK@183967|Thermoplasmata	183967|Thermoplasmata	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_4633858_3	1236689.MMALV_15270	3.229e-05	52.0	COG1371@1|root,arCOG04055@2157|Archaea,2Y6XM@28890|Euryarchaeota,3F2S4@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently	-	-	-	-	-	-	-	-	-	-	-	-	Archease
MMS2_k127_4633858_2	273116.14324989	7.728e-84	281.0	COG1945@1|root,arCOG04490@2157|Archaea,2XY3V@28890|Euryarchaeota,24249@183967|Thermoplasmata	183967|Thermoplasmata	E	arginine decarboxylase activity	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
MMS2_k127_4633858_1	273075.Ta0777	9.585e-109	357.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,241JC@183967|Thermoplasmata	183967|Thermoplasmata	J	leucyl-tRNA aminoacylation	leuS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
MMS2_k127_4763997_4	177439.DP0761	5.332e-12	73.0	COG1018@1|root,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,43BUF@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Oxidoreductase FAD-binding domain	poxF	-	1.17.1.1,1.18.1.7	ko:K00523,ko:K14581,ko:K16246,ko:K18225	ko00361,ko00362,ko00520,ko00623,ko00624,ko00626,ko00627,ko00633,ko00640,ko00642,ko01100,ko01120,ko01220,map00361,map00362,map00520,map00623,map00624,map00626,map00627,map00633,map00640,map00642,map01100,map01120,map01220	M00534,M00548,M00638	R02968,R03391,R03392,R03560,R03608,R05422,R05423,R05424,R05425,R05426,R05427,R06909,R06930,R06937,R07704,R07706,R07709,R07710,R09159,R09233,R10042,R10043,R10702	RC00046,RC00091,RC00098,RC00157,RC00230,RC00274,RC00275,RC00490,RC01376,RC01377,RC01801,RC03249	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
MMS2_k127_4763997_0	273075.Ta1155	3.475e-121	396.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,241Q1@183967|Thermoplasmata	183967|Thermoplasmata	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
MMS2_k127_4763997_3	273116.14325497	1.07e-20	97.0	COG1658@1|root,arCOG01486@2157|Archaea	2157|Archaea	L	Belongs to the UPF0292 family	-	-	-	-	-	-	-	-	-	-	-	-	Toprim,Toprim_4
MMS2_k127_4763997_2	263820.PTO0450	8.089e-24	104.0	COG1849@1|root,arCOG01224@2157|Archaea,2XYS0@28890|Euryarchaeota,241T6@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
MMS2_k127_4763997_1	273075.Ta0305	1.509e-27	115.0	arCOG06958@1|root,arCOG06958@2157|Archaea,2Y0YB@28890|Euryarchaeota,242CP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4774909_2	263820.PTO0191	1.318e-13	72.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,241QB@183967|Thermoplasmata	183967|Thermoplasmata	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
MMS2_k127_4774909_1	273116.14324674	8.542e-45	168.0	arCOG05327@1|root,arCOG05327@2157|Archaea,2Y236@28890|Euryarchaeota,2429B@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4774909_0	273075.Ta0162m	7.046e-186	596.0	COG1902@1|root,arCOG00615@2157|Archaea,2XT27@28890|Euryarchaeota,241Z1@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8,Oxidored_FMN
MMS2_k127_4779290_0	273116.14324444	1.885e-171	552.0	COG0433@1|root,arCOG00280@2157|Archaea,2XT33@28890|Euryarchaeota,241YU@183967|Thermoplasmata	183967|Thermoplasmata	L	Type IV secretory system Conjugative DNA transfer	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
MMS2_k127_4779290_1	263820.PTO0240	7.737e-88	303.0	COG0420@1|root,arCOG00397@2157|Archaea,2XT7A@28890|Euryarchaeota,241W3@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
MMS2_k127_4779290_2	273075.Ta0157	1.774e-40	171.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota,241ZK@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	Rad50_zn_hook,SMC_N
MMS2_k127_4784696_0	273116.14325266	2.131e-134	442.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,241KV@183967|Thermoplasmata	183967|Thermoplasmata	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
MMS2_k127_4784696_3	263820.PTO0817	1.005e-35	143.0	arCOG03379@1|root,arCOG03379@2157|Archaea,2XZH1@28890|Euryarchaeota,241W9@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4784696_1	439481.Aboo_0772	8.869e-111	368.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,3F2FA@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	4Fe-4S single cluster domain	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
MMS2_k127_4784696_2	263820.PTO0967	7.492e-58	207.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,241U3@183967|Thermoplasmata	183967|Thermoplasmata	S	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
MMS2_k127_4824070_0	273116.14324285	1.746e-137	445.0	COG3367@1|root,arCOG02828@2157|Archaea,2XTPS@28890|Euryarchaeota,24244@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
MMS2_k127_4824070_1	273116.14324286	4.576e-120	401.0	arCOG05346@1|root,arCOG05346@2157|Archaea,2XWG1@28890|Euryarchaeota,241ZP@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_4824070_3	273116.14324289	1.781e-44	168.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,241V7@183967|Thermoplasmata	183967|Thermoplasmata	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
MMS2_k127_4824070_2	273075.Ta0044m	2.546e-82	276.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,241Z9@183967|Thermoplasmata	183967|Thermoplasmata	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
MMS2_k127_4996400_2	326427.Cagg_1020	6.486e-10	70.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia	32061|Chloroflexia	T	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
MMS2_k127_4996400_0	1232410.KI421424_gene1652	3.442e-38	151.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WN14@28221|Deltaproteobacteria,43TZB@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	beta-lactamase domain protein	ycbL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
MMS2_k127_4996400_1	1121920.AUAU01000012_gene2694	5.55e-32	132.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase M13	-	-	3.4.24.71	ko:K01415	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
MMS2_k127_4998920_1	273063.STK_21550	9.54e-52	191.0	COG3253@1|root,arCOG03031@2157|Archaea,2XS88@28889|Crenarchaeota	28889|Crenarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
MMS2_k127_4998920_0	273116.14325020	5.375e-66	235.0	COG0301@1|root,COG0607@1|root,arCOG00038@2157|Archaea,arCOG02021@2157|Archaea,2XUHM@28890|Euryarchaeota,241US@183967|Thermoplasmata	183967|Thermoplasmata	HP	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rhodanese,THUMP,ThiI
MMS2_k127_559698_4	525909.Afer_0567	4.56e-20	93.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4CMVJ@84992|Acidimicrobiia	84992|Acidimicrobiia	H	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
MMS2_k127_559698_3	1459636.NTE_02653	8.316e-32	128.0	COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	SUF system FeS assembly protein	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
MMS2_k127_559698_0	273116.14325653	1.839e-149	486.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,241J5@183967|Thermoplasmata	183967|Thermoplasmata	J	Anticodon binding domain	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
MMS2_k127_559698_2	273075.Ta0207	2.641e-78	271.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,241RP@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
MMS2_k127_559698_5	273116.14325610	6.54e-10	62.0	COG0640@1|root,arCOG00394@2157|Archaea,2Y5A1@28890|Euryarchaeota,242H3@183967|Thermoplasmata	183967|Thermoplasmata	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_559698_1	273116.14325473	1.052e-91	312.0	COG1287@1|root,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,241Y6@183967|Thermoplasmata	183967|Thermoplasmata	I	oligosaccharyl transferase activity	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	PMT_2
MMS2_k127_561905_8	1343739.PAP_05820	1.035e-05	48.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,242R1@183968|Thermococci	183968|Thermococci	V	K homology RNA-binding domain	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
MMS2_k127_561905_7	1382304.JNIL01000001_gene1097	2.337e-30	130.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli	91061|Bacilli	F	amidohydrolase	-	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
MMS2_k127_561905_5	70601.3257221	2.404e-81	281.0	COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243RX@183968|Thermococci	183968|Thermococci	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_561905_3	633148.Tagg_0698	2.132e-85	293.0	COG0444@1|root,arCOG00181@2157|Archaea,2XPR3@28889|Crenarchaeota	28889|Crenarchaeota	E	TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
MMS2_k127_561905_6	1184251.TCELL_1206	1.733e-77	271.0	COG1173@1|root,arCOG00748@2157|Archaea,2XQGC@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_561905_2	1184251.TCELL_1207	3.621e-93	317.0	COG0601@1|root,arCOG00751@2157|Archaea,2XQNC@28889|Crenarchaeota	28889|Crenarchaeota	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_561905_0	490899.DKAM_0867	1.187e-97	343.0	COG0747@1|root,arCOG01534@2157|Archaea,2XQ84@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_561905_4	1184251.TCELL_1206	5.002e-82	281.0	COG1173@1|root,arCOG00748@2157|Archaea,2XQGC@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
MMS2_k127_561905_1	1184251.TCELL_1207	4.426e-94	318.0	COG0601@1|root,arCOG00751@2157|Archaea,2XQNC@28889|Crenarchaeota	28889|Crenarchaeota	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
MMS2_k127_589875_11	933801.Ahos_0164	1.949e-07	64.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_589875_4	263820.PTO0715	1.008e-82	278.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,241RH@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
MMS2_k127_589875_3	273116.14324753	4.225e-110	364.0	COG0010@1|root,arCOG01700@2157|Archaea,2XTEP@28890|Euryarchaeota,241N8@183967|Thermoplasmata	183967|Thermoplasmata	E	Arginase family	-	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
MMS2_k127_589875_8	2850.Phatr17954	1.238e-11	70.0	COG0231@1|root,KOG3271@2759|Eukaryota,2XCF6@2836|Bacillariophyta	2836|Bacillariophyta	J	Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold	-	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
MMS2_k127_589875_0	273116.14324730	1.798e-141	460.0	COG0402@1|root,arCOG00695@2157|Archaea,2XTJS@28890|Euryarchaeota,241JE@183967|Thermoplasmata	183967|Thermoplasmata	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
MMS2_k127_589875_10	273075.Ta0918	8.325e-11	73.0	arCOG07396@1|root,arCOG07396@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_589875_5	273075.Ta0919	4.139e-78	277.0	COG1721@1|root,arCOG02742@2157|Archaea,2Y1T5@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
MMS2_k127_589875_1	273116.14325329	4.916e-128	417.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota	28890|Euryarchaeota	S	ATPase associated with various cellular activities	moxR4	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
MMS2_k127_589875_9	273116.14325330	1.943e-11	71.0	arCOG07743@1|root,arCOG07743@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_589875_7	273075.Ta0922	1.134e-27	119.0	arCOG07397@1|root,arCOG07397@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_589875_6	273116.14325332	6.999e-46	191.0	arCOG07398@1|root,arCOG07398@2157|Archaea	2157|Archaea	O	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
MMS2_k127_589875_2	273116.14325333	1.268e-123	409.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,241NM@183967|Thermoplasmata	183967|Thermoplasmata	J	PUA domain	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA
MMS2_k127_596155_1	263820.PTO1327	4.436e-76	264.0	COG0306@1|root,arCOG02267@2157|Archaea,2Y0C9@28890|Euryarchaeota,2421W@183967|Thermoplasmata	183967|Thermoplasmata	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
MMS2_k127_596155_0	273075.Ta0421	5.291e-294	914.0	COG0365@1|root,arCOG04201@2157|Archaea,2Y84I@28890|Euryarchaeota,2424Z@183967|Thermoplasmata	183967|Thermoplasmata	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
MMS2_k127_596155_2	273116.14325133	3.95e-41	161.0	arCOG03534@1|root,arCOG03534@2157|Archaea	2157|Archaea	S	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
MMS2_k127_596155_4	490899.DKAM_1304	4.012e-11	66.0	arCOG05414@1|root,arCOG05414@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
MMS2_k127_596155_3	768672.Desfe_1400	3.194e-20	96.0	arCOG03706@1|root,arCOG03706@2157|Archaea	2157|Archaea	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
MMS2_k127_59772_1	386456.JQKN01000001_gene1821	5.305e-35	143.0	COG1668@1|root,arCOG01462@2157|Archaea,2Y3YK@28890|Euryarchaeota	28890|Euryarchaeota	C	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
MMS2_k127_59772_0	386456.JQKN01000001_gene1822	2.677e-101	338.0	COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota	28890|Euryarchaeota	E	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
MMS2_k127_59772_2	671065.MetMK1DRAFT_00008580	0.0001854	53.0	COG1846@1|root,arCOG00732@2157|Archaea,2XSCA@28889|Crenarchaeota	28889|Crenarchaeota	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
MMS2_k127_612950_1	273116.14324616	1.239e-29	117.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,241MQ@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
MMS2_k127_612950_2	273075.Ta1191	1.016e-27	123.0	COG1676@1|root,arCOG01701@2157|Archaea,2Y6AD@28890|Euryarchaeota,241VY@183967|Thermoplasmata	183967|Thermoplasmata	J	Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity)	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo
MMS2_k127_612950_3	273075.Ta1192	9.021e-25	110.0	COG1100@1|root,arCOG05343@2157|Archaea,2Y5BB@28890|Euryarchaeota	28890|Euryarchaeota	S	GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Ras
MMS2_k127_612950_0	273116.14324619	1.131e-54	198.0	COG1167@1|root,arCOG00492@2157|Archaea,2XVD6@28890|Euryarchaeota,241ZA@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
MMS2_k127_665033_0	273116.14325473	7.419e-298	976.0	COG1287@1|root,arCOG05365@2157|Archaea,2Y7QJ@28890|Euryarchaeota,241Y6@183967|Thermoplasmata	183967|Thermoplasmata	I	oligosaccharyl transferase activity	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	PMT_2
MMS2_k127_665033_5	273075.Ta1135	1.393e-36	148.0	arCOG05366@1|root,arCOG05366@2157|Archaea,2Y11W@28890|Euryarchaeota,241WB@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CARDB
MMS2_k127_665033_3	273116.14325471	3.238e-52	191.0	arCOG03142@1|root,arCOG03142@2157|Archaea,2XTSE@28890|Euryarchaeota,24268@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_665033_1	273116.14325470	8.736e-147	477.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,241PR@183967|Thermoplasmata	183967|Thermoplasmata	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DHHA1
MMS2_k127_665033_4	273116.14325469	2.507e-43	163.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,241UD@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
MMS2_k127_665033_2	273116.14325455	6.103e-67	235.0	COG1756@1|root,arCOG04122@2157|Archaea,2XX9G@28890|Euryarchaeota,24276@183967|Thermoplasmata	183967|Thermoplasmata	J	Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA	nep1	-	2.1.1.260	ko:K14568	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009	-	-	-	EMG1
MMS2_k127_665033_6	309807.SRU_1214	0.0001651	44.0	COG1028@1|root,COG1028@2|Bacteria,4NE45@976|Bacteroidetes,1FJRI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IQ	KR domain	ykuF	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
MMS2_k127_668543_18	273116.14325323	1.644e-08	55.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,242BE@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	albA	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
MMS2_k127_668543_7	263820.PTO1199	3.274e-107	356.0	COG0142@1|root,arCOG01726@2157|Archaea,2XT85@28890|Euryarchaeota,241QG@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS2_k127_668543_0	273116.14325320	4.436e-195	620.0	COG1012@1|root,arCOG01252@2157|Archaea,2XUKB@28890|Euryarchaeota,2421F@183967|Thermoplasmata	183967|Thermoplasmata	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
MMS2_k127_668543_15	273116.14325386	2.42e-36	149.0	COG0620@1|root,arCOG01877@2157|Archaea,2Y7B1@28890|Euryarchaeota,2429I@183967|Thermoplasmata	183967|Thermoplasmata	E	Methionine synthase II (cobalamin-independent)	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	-
MMS2_k127_668543_6	263820.PTO0186	9.106e-128	417.0	COG0620@1|root,arCOG01876@2157|Archaea,2XUCW@28890|Euryarchaeota,24222@183967|Thermoplasmata	183967|Thermoplasmata	E	Catalyzes the transfer of a methyl group to L- homocysteine resulting in methionine formation. The physiological methyl donor is	metE	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
MMS2_k127_668543_4	263820.PTO0187	3.049e-149	512.0	COG4934@1|root,arCOG03665@2157|Archaea,2Y1PU@28890|Euryarchaeota,241Z3@183967|Thermoplasmata	183967|Thermoplasmata	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
MMS2_k127_668543_9	263820.PTO0802	8.13e-95	323.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,241NB@183967|Thermoplasmata	183967|Thermoplasmata	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
MMS2_k127_668543_11	1162668.LFE_0447	1.488e-62	218.0	COG1592@1|root,COG1592@2|Bacteria,3J0RY@40117|Nitrospirae	40117|Nitrospirae	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
MMS2_k127_668543_17	638303.Thal_0939	5.496e-20	96.0	COG0247@1|root,COG0247@2|Bacteria	2|Bacteria	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
MMS2_k127_668543_2	273075.Ta0974	1.303e-169	539.0	COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,2425E@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_668543_12	273075.Ta0973	1.063e-58	216.0	COG1801@1|root,arCOG04291@2157|Archaea	2157|Archaea	L	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
MMS2_k127_668543_8	263820.PTO1397	9.972e-97	330.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,241SW@183967|Thermoplasmata	183967|Thermoplasmata	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
MMS2_k127_668543_3	273116.14325379	1.006e-152	502.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,241KN@183967|Thermoplasmata	183967|Thermoplasmata	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GatB_N
MMS2_k127_668543_13	263820.PTO1400	3.428e-45	168.0	COG0838@1|root,arCOG01557@2157|Archaea,2Y7BF@28890|Euryarchaeota,242B8@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
MMS2_k127_668543_10	273075.Ta0969m	3.607e-86	287.0	COG0377@1|root,arCOG01554@2157|Archaea,2XTP1@28890|Euryarchaeota,241SV@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.5.98.3,1.6.5.3	ko:K00331,ko:K22159	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1,3.D.9.1	-	-	Oxidored_q6
MMS2_k127_668543_16	760142.Hipma_0234	3.401e-26	113.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,2M6PV@213113|Desulfurellales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
MMS2_k127_668543_1	273116.14325375	5.055e-195	612.0	COG0649@1|root,arCOG01548@2157|Archaea,2XTWF@28890|Euryarchaeota,241MP@183967|Thermoplasmata	183967|Thermoplasmata	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
MMS2_k127_668543_5	273116.14325374	1.314e-136	445.0	COG1005@1|root,arCOG01546@2157|Archaea,2XT7N@28890|Euryarchaeota,241R1@183967|Thermoplasmata	183967|Thermoplasmata	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
MMS2_k127_668543_14	273116.14325373	3.727e-44	162.0	COG1143@1|root,arCOG01543@2157|Archaea,2Y79M@28890|Euryarchaeota,241VP@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
MMS2_k127_67833_2	273116.14325654	2.162e-18	93.0	COG0719@1|root,arCOG01715@2157|Archaea,2Y3DN@28890|Euryarchaeota,2426Z@183967|Thermoplasmata	183967|Thermoplasmata	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
MMS2_k127_67833_0	273075.Ta0203	3.586e-254	789.0	COG0719@1|root,arCOG01715@2157|Archaea,2XTY9@28890|Euryarchaeota,241R3@183967|Thermoplasmata	183967|Thermoplasmata	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
MMS2_k127_67833_1	273075.Ta0202	1.616e-106	351.0	COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,241QJ@183967|Thermoplasmata	183967|Thermoplasmata	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
MMS2_k127_689051_3	263820.PTO1253	7.958e-51	191.0	COG0348@1|root,arCOG03696@2157|Archaea	2157|Archaea	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_10
MMS2_k127_689051_0	387631.Asulf_01938	2.254e-150	494.0	COG0318@1|root,arCOG00856@2157|Archaea,2XSZG@28890|Euryarchaeota,246KT@183980|Archaeoglobi	183980|Archaeoglobi	I	to SP P29212 GB L02649 GB X70994 PID 581070 GB U00096 percent identity	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
MMS2_k127_689051_2	263820.PTO0348	2.969e-54	198.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,241RE@183967|Thermoplasmata	183967|Thermoplasmata	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
MMS2_k127_689051_4	273075.Ta0314	4.08e-37	148.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y10D@28890|Euryarchaeota,242AI@183967|Thermoplasmata	183967|Thermoplasmata	S	ribosomal small subunit binding	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_689051_1	452637.Oter_1810	1.486e-132	434.0	COG3590@1|root,COG3590@2|Bacteria,46UUX@74201|Verrucomicrobia	2|Bacteria	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
MMS2_k127_697261_3	273075.Ta0065m	2.977e-30	135.0	COG3368@1|root,arCOG02444@2157|Archaea,2Y68C@28890|Euryarchaeota,2428U@183967|Thermoplasmata	183967|Thermoplasmata	S	Membrane protein of 12 TMs	-	-	-	ko:K07087	-	-	-	-	ko00000	-	-	-	12TM_1
MMS2_k127_697261_1	263820.PTO0203	2.878e-41	157.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,241U2@183967|Thermoplasmata	183967|Thermoplasmata	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
MMS2_k127_697261_2	273075.Ta0052	4.856e-33	130.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,241XG@183967|Thermoplasmata	183967|Thermoplasmata	S	DNA binding	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
MMS2_k127_697261_6	273075.Ta0053	4.737e-15	76.0	COG2167@1|root,arCOG04177@2157|Archaea,2Y6WV@28890|Euryarchaeota,241X6@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	-	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
MMS2_k127_697261_4	273116.14324224	2.814e-25	107.0	COG2097@1|root,arCOG04473@2157|Archaea,2Y6GN@28890|Euryarchaeota,241W2@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
MMS2_k127_697261_0	273116.14324225	3.07e-65	229.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,241S3@183967|Thermoplasmata	183967|Thermoplasmata	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
MMS2_k127_697261_5	1006006.Mcup_0276	1.579e-16	82.0	COG0009@1|root,arCOG01952@2157|Archaea,2XPW0@28889|Crenarchaeota	28889|Crenarchaeota	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
MMS2_k127_699857_7	273116.14324649	5.339e-44	162.0	arCOG03678@1|root,arCOG03677@2157|Archaea,2Y0K5@28890|Euryarchaeota,242AH@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_699857_6	273075.Ta0069	3.056e-48	178.0	COG1591@1|root,arCOG00919@2157|Archaea,2XY2Q@28890|Euryarchaeota,241SS@183967|Thermoplasmata	183967|Thermoplasmata	L	Archaeal holliday junction resolvase (hjc)	-	-	-	-	-	-	-	-	-	-	-	-	Hjc
MMS2_k127_699857_0	273075.Ta0068	3.913e-199	629.0	COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2421R@183967|Thermoplasmata	183967|Thermoplasmata	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
MMS2_k127_699857_5	273116.14324237	1.167e-66	239.0	COG1814@1|root,arCOG01096@2157|Archaea,2XWEX@28890|Euryarchaeota,2423V@183967|Thermoplasmata	183967|Thermoplasmata	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
MMS2_k127_699857_1	273116.14324478	7.804e-102	342.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,241XW@183967|Thermoplasmata	183967|Thermoplasmata	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
MMS2_k127_699857_2	273116.14324479	1.445e-93	314.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,2422T@183967|Thermoplasmata	183967|Thermoplasmata	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
MMS2_k127_699857_3	439481.Aboo_0908	1.563e-73	255.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,3F2KG@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
MMS2_k127_699857_4	263820.PTO0906	3.706e-68	241.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,241PU@183967|Thermoplasmata	183967|Thermoplasmata	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
MMS2_k127_699857_8	273075.Ta0221	5.823e-18	88.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota	28890|Euryarchaeota	G	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
MMS2_k127_740519_3	273075.Ta1167	1.755e-23	101.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,241QV@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
MMS2_k127_740519_1	273116.14324691	7.966e-114	380.0	COG2235@1|root,arCOG03108@2157|Archaea,2XX08@28890|Euryarchaeota,241XU@183967|Thermoplasmata	183967|Thermoplasmata	E	Amidinotransferase	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
MMS2_k127_740519_2	263820.PTO1421	2.881e-34	144.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,241U8@183967|Thermoplasmata	183967|Thermoplasmata	J	NMD3 family	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
MMS2_k127_740519_0	273116.14325531	3.42e-147	475.0	COG1960@1|root,arCOG01707@2157|Archaea,2XSVA@28890|Euryarchaeota,2421G@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_795566_1	263820.PTO0880	1.015e-98	329.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,241JN@183967|Thermoplasmata	183967|Thermoplasmata	K	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
MMS2_k127_795566_8	1205753.A989_15993	0.0009013	51.0	2F4AD@1|root,33X10@2|Bacteria,1NVNB@1224|Proteobacteria,1SRSZ@1236|Gammaproteobacteria,1XAIQ@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_795566_7	269797.Mbar_A1410	3.429e-10	65.0	COG3335@1|root,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota,2N9Y3@224756|Methanomicrobia	224756|Methanomicrobia	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32,HTH_33
MMS2_k127_795566_6	1094980.Mpsy_2971	1.105e-17	84.0	COG3335@1|root,COG3415@1|root,arCOG02128@2157|Archaea,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota,2N9Y3@224756|Methanomicrobia	224756|Methanomicrobia	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32,HTH_33
MMS2_k127_795566_0	273116.14324694	3.27e-102	345.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,241YK@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
MMS2_k127_795566_5	263820.PTO0870	1.165e-18	86.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota,241WR@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
MMS2_k127_795566_4	273116.14324697	1.001e-29	121.0	COG2004@1|root,arCOG04182@2157|Archaea,2Y7BU@28890|Euryarchaeota,242EA@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
MMS2_k127_795566_3	273116.14324698	1.671e-44	168.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,241XB@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF359)	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
MMS2_k127_795566_2	273075.Ta1089m	1.428e-72	249.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,241RJ@183967|Thermoplasmata	183967|Thermoplasmata	K	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
MMS2_k127_79724_3	439481.Aboo_0781	9.827e-49	184.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,3F2JX@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	GO:0003674,GO:0003824,GO:0003933,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044682	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
MMS2_k127_79724_5	273075.Ta1137	4.653e-27	113.0	COG1382@1|root,arCOG01342@2157|Archaea,2Y79P@28890|Euryarchaeota,241WC@183967|Thermoplasmata	183967|Thermoplasmata	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
MMS2_k127_79724_4	1449063.JMLS01000034_gene2393	1.271e-41	158.0	COG2128@1|root,COG2128@2|Bacteria,1V97G@1239|Firmicutes,4HHFF@91061|Bacilli,26XRX@186822|Paenibacillaceae	91061|Bacilli	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	ydfG	-	-	-	-	-	-	-	-	-	-	-	CMD
MMS2_k127_79724_0	273116.14324864	7.339e-157	504.0	COG0183@1|root,arCOG01282@2157|Archaea,2XT8C@28890|Euryarchaeota,241KE@183967|Thermoplasmata	183967|Thermoplasmata	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_79724_1	273116.14324231	1.924e-55	203.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,2428Q@183967|Thermoplasmata	183967|Thermoplasmata	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS2_k127_79724_2	1459636.NTE_02448	3.51e-54	203.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine synthase	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
MMS2_k127_79724_6	263820.PTO0856	2.042e-11	64.0	COG1196@1|root,arCOG00371@2157|Archaea,2XSVK@28890|Euryarchaeota,241K1@183967|Thermoplasmata	183967|Thermoplasmata	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
MMS2_k127_810119_5	273116.14324639	2.555e-36	139.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,241RW@183967|Thermoplasmata	183967|Thermoplasmata	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
MMS2_k127_810119_4	263820.PTO0436	2.969e-47	178.0	COG2045@1|root,arCOG04871@2157|Archaea,2Y673@28890|Euryarchaeota,2429Z@183967|Thermoplasmata	183967|Thermoplasmata	H	2-phosphosulfolactate phosphatase activity	comB	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
MMS2_k127_810119_6	273116.14325713	2.316e-26	117.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,241R2@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
MMS2_k127_810119_1	273116.14325712	2.317e-134	438.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,241T0@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
MMS2_k127_810119_7	263820.PTO0433	2.551e-24	103.0	arCOG05337@1|root,arCOG05337@2157|Archaea,2Y4WJ@28890|Euryarchaeota,242BU@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_810119_0	273075.Ta1455	1.13e-193	608.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,241IW@183967|Thermoplasmata	183967|Thermoplasmata	I	transferase activity, transferring acyl groups	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C
MMS2_k127_810119_2	693661.Arcve_2047	2.543e-99	336.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,245TY@183980|Archaeoglobi	183980|Archaeoglobi	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
MMS2_k127_810119_3	273116.14324348	1.163e-56	203.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,241SY@183967|Thermoplasmata	183967|Thermoplasmata	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
MMS2_k127_823923_3	330214.NIDE3340	3.951e-21	92.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.10.1.1,2.7.7.77	ko:K03750,ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R09735,R11581	RC03462	ko00000,ko00001,ko01000	-	-	iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	MoCF_biosynth,MobB,MoeA_C,MoeA_N
MMS2_k127_823923_1	649747.HMPREF0083_05195	2.003e-69	244.0	COG0179@1|root,COG0179@2|Bacteria,1UY98@1239|Firmicutes,4HC89@91061|Bacilli,26UR6@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
MMS2_k127_823923_0	1444309.JAQG01000191_gene642	5.347e-107	358.0	COG3508@1|root,COG3508@2|Bacteria,1UYZ0@1239|Firmicutes,4HCCC@91061|Bacilli,26V1U@186822|Paenibacillaceae	91061|Bacilli	Q	homogentisate 1,2-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
MMS2_k127_823923_2	273075.Ta0885m	1.764e-29	122.0	COG1661@1|root,arCOG04212@2157|Archaea,2Y7CU@28890|Euryarchaeota,242DU@183967|Thermoplasmata	183967|Thermoplasmata	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
MMS2_k127_823923_4	399549.Msed_0595	1.009e-20	98.0	COG0494@1|root,arCOG01072@2157|Archaea,2XSBU@28889|Crenarchaeota	28889|Crenarchaeota	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
MMS2_k127_823923_5	697303.Thewi_0445	1.952e-12	71.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,42FHB@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
MMS2_k127_831984_4	273116.14324771	8.481e-61	217.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,241UK@183967|Thermoplasmata	183967|Thermoplasmata	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
MMS2_k127_831984_11	273075.Ta1039	1.208e-08	60.0	COG1400@1|root,arCOG01217@2157|Archaea,2Y5W9@28890|Euryarchaeota,242GT@183967|Thermoplasmata	183967|Thermoplasmata	U	SRP19 protein	-	-	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
MMS2_k127_831984_6	263820.PTO0984	5.109e-39	149.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,241T7@183967|Thermoplasmata	183967|Thermoplasmata	J	structural constituent of ribosome	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
MMS2_k127_831984_10	273075.Ta0150	2.595e-15	83.0	arCOG05402@1|root,arCOG05402@2157|Archaea,2Y4HZ@28890|Euryarchaeota,242E2@183967|Thermoplasmata	183967|Thermoplasmata	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_831984_8	273075.Ta0306	5.116e-26	119.0	COG0170@1|root,arCOG01880@2157|Archaea,2Y7B2@28890|Euryarchaeota,2429J@183967|Thermoplasmata	183967|Thermoplasmata	I	PFAM phosphatidate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_831984_9	273075.Ta0457	3.38e-17	92.0	COG0454@1|root,arCOG00846@2157|Archaea,2Y7B4@28890|Euryarchaeota,2429P@183967|Thermoplasmata	183967|Thermoplasmata	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_831984_3	273116.14324997	5.628e-178	567.0	COG0281@1|root,arCOG00853@2157|Archaea,2XSTN@28890|Euryarchaeota,241JH@183967|Thermoplasmata	183967|Thermoplasmata	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
MMS2_k127_831984_7	273116.14324998	1.783e-27	117.0	COG0454@1|root,arCOG00826@2157|Archaea,2Y7AX@28890|Euryarchaeota,24283@183967|Thermoplasmata	183967|Thermoplasmata	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
MMS2_k127_831984_5	273075.Ta1441	3.936e-50	187.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,242F5@183967|Thermoplasmata	183967|Thermoplasmata	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
MMS2_k127_831984_1	1121033.AUCF01000001_gene2391	3.281e-238	757.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,2JPD9@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
MMS2_k127_831984_2	247490.KSU1_C1303	2.623e-179	581.0	COG0366@1|root,COG0366@2|Bacteria,2IYAN@203682|Planctomycetes	203682|Planctomycetes	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
MMS2_k127_831984_0	263820.PTO0069	1.506e-276	858.0	COG0366@1|root,arCOG02948@2157|Archaea,2XUE6@28890|Euryarchaeota,242G6@183967|Thermoplasmata	183967|Thermoplasmata	G	Alpha-amylase domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
MMS2_k127_831984_12	1192034.CAP_8736	5.674e-07	56.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,42QDJ@68525|delta/epsilon subdivisions,2WIJ9@28221|Deltaproteobacteria,2Z2XS@29|Myxococcales	28221|Deltaproteobacteria	G	Maltogenic Amylase, C-terminal domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
MMS2_k127_852366_8	273116.14324810	7.734e-82	284.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y695@28890|Euryarchaeota,241ZB@183967|Thermoplasmata	183967|Thermoplasmata	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
MMS2_k127_852366_2	263820.PTO1045	4.737e-146	477.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,241N2@183967|Thermoplasmata	183967|Thermoplasmata	C	FAD binding domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
MMS2_k127_852366_3	1382304.JNIL01000001_gene1410	1.659e-117	386.0	COG1072@1|root,COG1072@2|Bacteria,1TPHJ@1239|Firmicutes,4HA4K@91061|Bacilli	91061|Bacilli	F	Pantothenic acid kinase	coaA	GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.33	ko:K00867	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
MMS2_k127_852366_6	930945.SiRe_0569	2.712e-92	318.0	COG0477@1|root,arCOG02691@2157|Archaea,2XRK4@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
MMS2_k127_852366_13	273116.14325008	2.311e-09	61.0	COG1369@1|root,arCOG01365@2157|Archaea	2157|Archaea	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
MMS2_k127_852366_7	273116.14324749	2.2e-86	301.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,241QY@183967|Thermoplasmata	183967|Thermoplasmata	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
MMS2_k127_852366_4	263820.PTO0985	3.561e-94	329.0	COG2244@1|root,arCOG02209@2157|Archaea,2XZR0@28890|Euryarchaeota,2422Z@183967|Thermoplasmata	183967|Thermoplasmata	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
MMS2_k127_852366_0	273116.14325439	7.93e-166	531.0	COG1960@1|root,arCOG04310@2157|Archaea,2XXBZ@28890|Euryarchaeota,2426V@183967|Thermoplasmata	183967|Thermoplasmata	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
MMS2_k127_852366_1	263820.PTO1196	5.049e-164	525.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,241MW@183967|Thermoplasmata	183967|Thermoplasmata	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
MMS2_k127_852366_9	1056495.Calag_1003	1.01e-63	248.0	COG3391@1|root,arCOG06052@1|root,arCOG02560@2157|Archaea,arCOG06052@2157|Archaea,2XRYP@28889|Crenarchaeota	28889|Crenarchaeota	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_852366_5	273075.Ta1322	1.907e-93	336.0	COG3391@1|root,arCOG02560@2157|Archaea,2Y65W@28890|Euryarchaeota,242AM@183967|Thermoplasmata	183967|Thermoplasmata	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
MMS2_k127_852366_14	273075.Ta0035	3.314e-09	64.0	COG5592@1|root,arCOG06046@2157|Archaea	2157|Archaea	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
MMS2_k127_852366_10	263820.PTO1489	3.929e-33	142.0	COG1506@1|root,arCOG01646@2157|Archaea,2XU9I@28890|Euryarchaeota,2422H@183967|Thermoplasmata	183967|Thermoplasmata	E	Prolyl oligopeptidase family	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9
MMS2_k127_882630_2	273075.Ta1075	5.738e-115	378.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,241MF@183967|Thermoplasmata	183967|Thermoplasmata	F	phosphoglycerate kinase activity	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
MMS2_k127_882630_11	304371.MCP_0009	0.0003245	49.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y0EU@28890|Euryarchaeota,2NBIM@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
MMS2_k127_882630_4	263820.PTO1516	1.338e-92	312.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,241MV@183967|Thermoplasmata	183967|Thermoplasmata	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
MMS2_k127_882630_3	273075.Ta1282m	2.411e-98	325.0	COG1709@1|root,arCOG04060@2157|Archaea,2XT58@28890|Euryarchaeota,241N9@183967|Thermoplasmata	183967|Thermoplasmata	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07731	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
MMS2_k127_882630_10	1227497.C491_01646	1.55e-10	67.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,23V57@183963|Halobacteria	183963|Halobacteria	K	protein conserved in archaea	tfx	-	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
MMS2_k127_882630_5	399549.Msed_1780	2.536e-73	259.0	COG0725@1|root,arCOG00219@2157|Archaea,2XR4G@28889|Crenarchaeota	28889|Crenarchaeota	P	ABC-type molybdate transport system periplasmic	-	-	-	ko:K15495	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	SBP_bac_11
MMS2_k127_882630_6	671065.MetMK1DRAFT_00023970	2.044e-56	206.0	COG0555@1|root,arCOG00164@2157|Archaea,2XQTS@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K15496	ko02010,map02010	M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.5	-	-	BPD_transp_1
MMS2_k127_882630_7	399549.Msed_1613	2.003e-35	143.0	COG3839@1|root,arCOG05705@2157|Archaea	2157|Archaea	P	ABC transporter	-	-	3.6.3.55	ko:K15497	ko02010,map02010	M00423	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5	-	-	ABC_tran
MMS2_k127_882630_1	263820.PTO0541	1.732e-117	386.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTRS@28890|Euryarchaeota,2424I@183967|Thermoplasmata	183967|Thermoplasmata	M	Male sterility protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
MMS2_k127_882630_0	330779.Saci_1769	9.892e-134	442.0	COG3511@1|root,arCOG05966@2157|Archaea,2XRK9@28889|Crenarchaeota	2157|Archaea	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
MMS2_k127_882630_8	273075.Ta1460	1.301e-28	127.0	COG1597@1|root,arCOG08932@2157|Archaea	2157|Archaea	I	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
MMS2_k127_882630_9	1089546.AQUI01000002_gene2308	3.436e-25	109.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4269,HIT
MMS2_k127_905751_2	263820.PTO1380	4.613e-16	81.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,241JB@183967|Thermoplasmata	183967|Thermoplasmata	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
MMS2_k127_905751_1	673860.AciM339_0632	1.836e-27	120.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,3F2MK@33867|unclassified Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	ribG	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
MMS2_k127_905751_0	273116.14325254	5.259e-175	556.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,241J8@183967|Thermoplasmata	183967|Thermoplasmata	F	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
MMS2_k127_911564_5	273116.14325399	3.354e-28	115.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,241XF@183967|Thermoplasmata	183967|Thermoplasmata	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
MMS2_k127_911564_3	273075.Ta0432	6.874e-51	183.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,241SC@183967|Thermoplasmata	183967|Thermoplasmata	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
MMS2_k127_911564_4	273116.14325397	2.203e-47	173.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,241TR@183967|Thermoplasmata	183967|Thermoplasmata	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
MMS2_k127_911564_6	1042877.GQS_04700	1.191e-21	98.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2444E@183968|Thermococci	183968|Thermococci	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
MMS2_k127_911564_2	273116.14324793	4.483e-63	228.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,241SK@183967|Thermoplasmata	183967|Thermoplasmata	J	SpoU rRNA Methylase family	-	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
MMS2_k127_911564_1	263820.PTO0328	9.121e-68	240.0	COG1047@1|root,arCOG00980@2157|Archaea,2XTB7@28890|Euryarchaeota,241ST@183967|Thermoplasmata	183967|Thermoplasmata	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K01802,ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
MMS2_k127_911564_0	273075.Ta0994	2.445e-151	496.0	COG0405@1|root,arCOG04053@2157|Archaea,2XUEX@28890|Euryarchaeota,2422W@183967|Thermoplasmata	183967|Thermoplasmata	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
MMS2_k127_911564_8	368408.Tpen_1621	3.048e-07	60.0	COG3413@1|root,arCOG02272@2157|Archaea	2157|Archaea	S	Bacterio-opsin activator HTH	-	-	1.5.1.40	ko:K06930,ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	BAT,HTH_10
MMS2_k127_911564_7	439481.Aboo_1255	1.292e-19	96.0	COG0747@1|root,arCOG01534@2157|Archaea,2XTPJ@28890|Euryarchaeota,3F353@33867|unclassified Euryarchaeota	28890|Euryarchaeota	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
MMS2_k127_933556_3	273116.14324586	9.227e-73	260.0	COG1290@1|root,arCOG01721@2157|Archaea,2XVE0@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1290 Cytochrome b subunit of the bc complex	petB2	-	-	ko:K15879	-	-	-	-	ko00000	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2
MMS2_k127_933556_7	273116.14324582	2.63e-38	152.0	COG1024@1|root,arCOG00239@2157|Archaea	2157|Archaea	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
MMS2_k127_933556_6	273075.Ta0520	4.171e-56	204.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,241UU@183967|Thermoplasmata	183967|Thermoplasmata	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
MMS2_k127_933556_0	273116.14325265	1.249e-144	467.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,241JV@183967|Thermoplasmata	183967|Thermoplasmata	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ,ThiG
MMS2_k127_933556_1	273116.14325418	2.786e-123	402.0	COG0730@1|root,arCOG02050@2157|Archaea,2XYUE@28890|Euryarchaeota,241RV@183967|Thermoplasmata	183967|Thermoplasmata	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
MMS2_k127_933556_8	273075.Ta0415	4.135e-28	117.0	COG4272@1|root,arCOG05396@2157|Archaea,2Y4XV@28890|Euryarchaeota,242DN@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1634)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
MMS2_k127_933556_5	263820.PTO0637	1.826e-68	235.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,242AD@183967|Thermoplasmata	183967|Thermoplasmata	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
MMS2_k127_933556_2	273075.Ta0343	8.278e-103	343.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota	28890|Euryarchaeota	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2,5.1.3.20	ko:K01784,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
MMS2_k127_933556_4	273075.Ta0344m	8.598e-71	244.0	COG2605@1|root,arCOG01030@2157|Archaea,2Y7BC@28890|Euryarchaeota,242B5@183967|Thermoplasmata	183967|Thermoplasmata	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
MMS2_k127_991315_3	1167006.UWK_00222	1.015e-18	98.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,2MI31@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iAF987.Gmet_2474	OstA,OstA_2,OstA_C
MMS2_k127_991315_1	397948.Cmaq_1664	1.072e-71	256.0	COG2355@1|root,arCOG04083@2157|Archaea,2XQ2V@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM peptidase M19 renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
MMS2_k127_991315_2	273116.14324610	5.775e-63	220.0	COG4754@1|root,arCOG05379@2157|Archaea,2Y3H9@28890|Euryarchaeota,24264@183967|Thermoplasmata	183967|Thermoplasmata	P	C-terminal AAA-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_assoc_C
MMS2_k127_991315_4	666510.ASAC_0133	2.345e-12	70.0	arCOG03694@1|root,arCOG03694@2157|Archaea,2XRJF@28889|Crenarchaeota	28889|Crenarchaeota	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
MMS2_k127_991315_0	399549.Msed_1496	7.028e-146	476.0	COG0591@1|root,arCOG01316@2157|Archaea,2XR75@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
## 1294 queries scanned
## Total time (seconds): 42.583136796951294
## Rate: 30.39 q/s